title: Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise.
abstract: Strenuous endurance exercise increases inflammatory markers and acutely increases cardiovascular risk; however, statins may mitigate this response. We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon. Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race. The increase in p-selectin immediately after exercise was lower in statin users (PRE to FINISH: 20.5 ± 19.4 ng/mL) than controls (PRE to FINISH: 30.9 ± 27.1 ng/mL; P < 0.001). The increase in p-selectin 24 hours after exercise was also lower in statin users (PRE to POST: 21.5 ± 26.6 ng/mL) than controls (PRE to POST: 29.3 ± 31.9 ng/mL; P < 0.001). Furthermore, LDL-C was positively correlated with p-selectin at FINISH and POST (P < 0.01 and P < 0.05, resp.), irrespective of drug treatment, suggesting that lower levels of LDL-C are associated with a reduced inflammatory response to exercise. We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Zaleski
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Capizzi
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA ; Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Ballard
authors.affiliation: Children's Hospital, Boston, MA 02115, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Troyanos
authors.affiliation: Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Baggish
authors.affiliation: Children's Hospital, Boston, MA 02115, USA.
authors.forename: Pierre
authors.initials: P
authors.lastname: D'Hemecourt
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thompson
authors.affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
authors.forename: Beth
authors.initials: B
authors.lastname: Parker