title: Genetic studies of rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is a common autoimmune disease that results in significant morbidity. As with other complex disorders, genome-wide association studies (GWASs) have greatly contributed to the current understanding of RA etiology. In this review, we describe the genetic configuration of RA as revealed primarily through GWASs and their meta-analyses. In addition, we discuss the pathologic mechanisms of RA as suggested by the findings of genetic and functional studies of individual RA-associated genes, including HLA-DRB1, PADI4, PTPN22, CCR6 and FCRL3, and the potential use of genetic information for RA treatment in clinical practice.
authors.affiliation: Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Okada
authors.forename: Akari
authors.initials: A
authors.lastname: Suzuki
authors.forename: Yuta
authors.initials: Y
authors.lastname: Kochi
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans
chemical_list: D000949:Histocompatibility Antigens Class II