title: Primary cardiac dedifferentiated liposarcoma with homologous and heterologous differentiation: a case report.
abstract: Liposarcoma originating in the heart is extraordinarily rare. Herein, we report a dedifferentiated liposarcoma arising from the left atrium in a 59-year-old Chinese man. Histologically, the neoplasm predominantly consisted of undifferentiated pleomorphic sarcoma. In addition, the neoplasm exhibited lipoblastic differentiation and osteo-/chondrosarcomatous components. Immunohistochemically, the neoplastic cells were strongly positive for p16, MDM2, and CDK4. Fluorescence in situ hybridization showed MDM2 gene amplification in all of the tumor components. To the best of our knowledge, this is the first published example of cardiac dedifferentiated liposarcoma exhibiting homologous and heterologous differentiation without a well-differentiated liposarcoma component.
authors.affiliation: Department of Pathology, West China Hospital, Sichuan University Chengdu, Sichuan, China.
authors.forename: Du
authors.initials: D
authors.lastname: He
authors.affiliation: Department of Pathology, West China Hospital, Sichuan University Chengdu, Sichuan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Pathology, West China Hospital, Sichuan University Chengdu, Sichuan, China.
authors.forename: Huijiao
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Pathology, West China Hospital, Sichuan University Chengdu, Sichuan, China.
authors.forename: Dianying
authors.initials: D
authors.lastname: Liao
authors.affiliation: Department of Radiology, Meishan City People's Hospital Meishan, Sichuan, China.
authors.forename: Xiaozhou
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, West China Hospital, Sichuan University Chengdu, Sichuan, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Pathology, West China Hospital, Sichuan University Chengdu, Sichuan, China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002454:Cell Differentiation; D017809:Fatal Outcome; D006338:Heart Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008080:Liposarcoma / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
keywords: Liposarcoma; heart