title: Genome Sequencing of Multiple Isolates Highlights Subtelomeric Genomic Diversity within Fusarium fujikuroi.
abstract: Comparisons of draft genome sequences of three geographically distinct isolates of Fusarium fujikuroi with two recently published genome sequences from the same species suggest diverse profiles of secondary metabolite production within F. fujikuroi. Species- and lineage-specific genes, many of which appear to exhibit expression profiles that are consistent with roles in host-pathogen interactions and adaptation to environmental changes, are concentrated in subtelomeric regions. These genomic compartments also exhibit distinct gene densities and compositional characteristics with respect to other genomic partitions, and likely play a role in the generation of molecular diversity. Our data provide additional evidence that gene duplication, divergence, and differential loss play important roles in F. fujikuroi genome evolution and suggest that hundreds of lineage-specific genes might have been acquired through horizontal gene transfer.
authors.affiliation: Department of Biosciences, University of Milan, Italy Institute of Biomembranes and Bioenergetics, National Research Council, Bari, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Chiara
authors.affiliation: Institute of Sciences of Food Production, National Research Council, Bari, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Fanelli
authors.affiliation: Institute of Sciences of Food Production, National Research Council, Bari, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Mulè
authors.affiliation: Institute of Sciences of Food Production, National Research Council, Bari, Italy.
authors.forename: Antonio F
authors.initials: AF
authors.lastname: Logrieco
authors.affiliation: Institute of Biomembranes and Bioenergetics, National Research Council, Bari, Italy Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy National Institute of Biostructures and Biosystems (INBB), Rome, Italy Center of Excellence in Comparative Genomics, University of Bari, Italy.
authors.forename: Graziano
authors.initials: G
authors.lastname: Pesole
authors.affiliation: Department of Plant Pathology, Kansas State University, Manhattan.
authors.forename: John F
authors.initials: JF
authors.lastname: Leslie
authors.affiliation: Department of Biosciences, University of Milan, Italy david.horner@unimi.it matteo.chiara@unimi.it toomajia@k-state.edu.
authors.forename: David S
authors.initials: DS
authors.lastname: Horner
authors.affiliation: Department of Plant Pathology, Kansas State University, Manhattan.
authors.forename: Christopher
authors.initials: C
authors.lastname: Toomajian
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D004271:DNA, Fungal / Q000235:genetics; D019143:Evolution, Molecular; D005670:Fusarium / Q000235:genetics*; D020440:Gene Duplication; D022761:Gene Transfer, Horizontal; D014644:Genetic Variation; D005828:Genetics, Population; D016681:Genome, Fungal; D023281:Genomics; D054884:Host-Pathogen Interactions / Q000235:genetics; D005810:Multigene Family; D010802:Phylogeny; D017422:Sequence Analysis, DNA
chemical_list: D004271:DNA, Fungal
keywords: comparative genomics; mycotoxin; secondary metabolites