title: Quantitative Assessment of Fluid Accumulation Using Bioelectrical Impedance Analysis in Patients With Acute Decompensated Heart Failure.
abstract: BACKGROUND
  Acute decompensated heart failure (ADHF) is generally considered to be a problem of fluid volume overload, therefore accurately quantifying the degree of fluid accumulation is of critical importance in assessing whether adequate decongestion has been achieved. The aim of this study was to develop and validate a method to quantify the degree of fluid accumulation in patients with ADHF.
  
  
  RESULTS
  Using multi-frequency bioelectrical impedance analysis (BIA), we measured extracellular water (ECW) volume in 130 ADHF patients on admission and at discharge. We also predicted optimal ECW volume using original equations based on data from 60 control subjects without the signs of HF. Measured/predicted (M/P) ratio of ECW in ADHF patients was observed to decrease from 1.26±0.25 to 1.04±0.17 during hospitalization (P<0.001). The amount of ECW volume reduction was significantly correlated with reduction in body weight (r=0.766, P<0.001). On multivariate analysis, higher M/P ratio of ECW at discharge was associated with increased risk of ADHF readmission or cardiac death within 6 months after discharge.
  
  
  CONCLUSIONS
  Multi-frequency BIA-measured ECW was found to offer valuable information for analyzing the pathophysiology of ADHF, and may be a useful guide in the management of this disease.
authors.affiliation: Division of Cardiology, National Hospital Organization Osaka National Hospital.
authors.forename: Taiki
authors.initials: T
authors.lastname: Sakaguchi
authors.forename: Kaori
authors.initials: K
authors.lastname: Yasumura
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nishida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inoue
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Furukawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shinouchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miura
authors.forename: Koichi
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Gou
authors.initials: G
authors.lastname: Hamano
authors.forename: Masao
authors.initials: M
authors.lastname: Koide
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Abe
authors.forename: Motoo
authors.initials: M
authors.lastname: Date
authors.forename: Keiji
authors.initials: K
authors.lastname: Hirooka
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Koretsune
authors.forename: Hideo
authors.initials: H
authors.lastname: Kusuoka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yasumura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017097:Electric Impedance; D045604:Extracellular Fluid / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission; D011237:Predictive Value of Tests; D012307:Risk Factors