title: Angiogenic activity of latex from Euphorbia tirucalli Linnaeus 1753 (Plantae, Euphorbiaceae).
abstract: To assess the pro-angiogenic activity of Euphorbia tirucalli, commonly known as "avelós" plant, we performed a series of tests by applying an aqueous E. tirucalli latex solution (10 mg/mL) to the chorioallantoic membranes (CAMs) of 80 fertilized chicken eggs incubated in a temperature- and humidity-controlled automatic incubator. The results indicated that the aqueous latex solution increased vascular network formation compared to that with the negative control (p < 0.05) and the inhibitor control (p < 0.05). This suggests that under the experimental conditions tested, the aqueous latex solution induced an inflammatory response leading to neoangiogenesis.
authors.affiliation: Pró-Reitoria de Pós-graduação e Pesquisa, Pontifícia Universidade Católica de Goiás, Goiânia, GO, BR.
authors.forename: G
authors.initials: G
authors.lastname: Bessa
authors.affiliation: Programa de Pós-graduação em Ciências Ambientais e Saúde, Departamento de Biomedicina e Farmácia, Pontifícia Universidade Católica de Goiás, Goiânia, GO, BR.
authors.forename: P R
authors.initials: PR
authors.lastname: Melo-Reis
authors.affiliation: Pró-Reitoria de Pós-graduação e Pesquisa, Pontifícia Universidade Católica de Goiás, Goiânia, GO, BR.
authors.forename: L A
authors.initials: LA
authors.lastname: Araújo
authors.affiliation: Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Goiânia, GO, BR.
authors.forename: F
authors.initials: F
authors.lastname: Mrué
authors.affiliation: Pró-Reitoria de Pós-graduação e Pesquisa, Pontifícia Universidade Católica de Goiás, Goiânia, GO, BR.
authors.forename: G B
authors.initials: GB
authors.lastname: Freitas
authors.affiliation: Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Goiânia, GO, BR.
authors.forename: M L
authors.initials: ML
authors.lastname: Brandão
authors.affiliation: Pró-Reitoria de Pós-graduação e Pesquisa, Pontifícia Universidade Católica de Goiás, Goiânia, GO, BR.
authors.forename: N J
authors.initials: NJ
authors.lastname: Silva Júnior
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D049033:Chorioallantoic Membrane; D028481:Euphorbia / Q000737:chemistry*; D007840:Latex / Q000494:pharmacology*
chemical_list: D043925:Angiogenesis Inducing Agents; D007840:Latex