title: Resolution-improved in situ DNA hybridization detection based on microwave photonic interrogation.
abstract: In situ bio-sensing system based on microwave photonics filter (MPF) interrogation method with improved resolution is proposed and experimentally demonstrated. A microfiber Bragg grating (mFBG) is used as sensing probe for DNA hybridization detection. Different from the traditional wavelength monitoring technique, we use the frequency interrogation scheme for resolution-improved bio-sensing detection. Experimental results show that the frequency shift of MPF notch presents a linear response to the surrounding refractive index (SRI) change over the range of 1.33 to 1.38, with a SRI resolution up to 2.6 × 10(-5) RIU, which has been increased for almost two orders of magnitude compared with the traditional fundamental mode monitoring technique (~3.6 × 10(-3) RIU). Due to the high Q value (about 27), the whole process of DNA hybridization can be in situ monitored. The proposed MPF-based bio-sensing system provides a new interrogation method over the frequency domain with improved sensing resolution and rapid interrogation rate for biochemical and environmental measurement.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Cao
authors.forename: Tuan
authors.initials: T
authors.lastname: Guo
authors.forename: Xudong
authors.initials: X
authors.lastname: Wang
authors.forename: Dandan
authors.initials: D
authors.lastname: Sun
authors.forename: Yang
authors.initials: Y
authors.lastname: Ran
authors.forename: Xinhuan
authors.initials: X
authors.lastname: Feng
authors.forename: Bai-ou
authors.initials: BO
authors.lastname: Guan