title: Prediction of noninertial focusing of red blood cells in Poiseuille flow.
abstract: The motions of a red blood cell in Poiseuille flows in a range of channel widths are simulated using a two-dimensional model. For a range of initial off-centerline distances in a 12-μm channel, cell trajectories converge to a specific off-centerline position and exhibit tank-treading motions. This behavior coexists with initial positions that lead to migration towards the centerline. The predicted off-centerline focusing effect is shown to depend on the curvature of the flow profile and on interactions with both solid boundaries.
authors.affiliation: Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, New Mexico 87131, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Hariprasad
authors.affiliation: Department of Physiology, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Secomb
mesh_terms: D002465:Cell Movement; D003198:Computer Simulation; D004548:Elasticity; D004912:Erythrocytes; D006439:Hemodynamics; D008833:Microcirculation; D008955:Models, Cardiovascular; D009038:Motion; D011312:Pressure; D014783:Viscosity