title: A Polyamine Twist on Hedgehog Signaling.
abstract: The Hedgehog pathway plays important roles in embryonic development and oncogenesis, but how it affects metabolism is less clear. D'Amico et al. (2015) now demonstrate that the Hedgehog pathway regulates translation of ornithine decarboxylase, thereby enhancing polyamine biosynthesis and cell proliferation in neural precursor cells and in brain tumors.
authors.affiliation: Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: rosalind_segal@dfci.harvard.edu.
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Segal
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D049109:Cell Proliferation; D005260:Female; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D008527:Medulloblastoma / Q000473:pathology*; D009474:Neurons / Q000166:cytology*; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism*
chemical_list: D053823:Hedgehog Proteins; D011073:Polyamines; D055372:AMP-Activated Protein Kinases; D009955:Ornithine Decarboxylase