title: Treatment Responsiveness in CIDP Patients with Diabetes Is Associated with Higher Degrees of Demyelination.
abstract: BACKGROUND
  Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is one of several chronic treatable acquired demyelinating neuropathies.
  
  
  OBJECTIVE
  To explore the association between the degree of demyelination in CIDP, and treatment responsiveness.
  
  
  METHODS
  A retrospective chart review of CIDP subjects assessed between 1997 and 2013 was performed to compare treatment responsiveness using different sets of criteria.
  
  
  RESULTS
  99 CIDP patients were included, 34 with diabetes mellitus (DM). Treatment responsiveness was higher in CIDP-DM fulfilling 1 or more EFNS/PNS criteria, (63% vs. 31%, p = 0.03), and in CIDP+DM fulfilling 2 or more criteria (89% vs. 36%, p = 0.01). Nonetheless, treatment responsiveness in CIDP+DM had the highest odds ratio (3.73, p = 0.01). Similar results were also shown in simplified uniform study criteria, with 10% cut off values for CIDP-DM, compared to 30% for CIDP+DM.
  
  
  CONCLUSIONS
  In CIDP+DM, higher degrees of demyelination are associated with treatment responsiveness, implying the need to adjust current criteria in these patients.
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Alon
authors.initials: A
authors.lastname: Abraham
authors.affiliation: Department of Neurology, King Fahad Hospital of the University, University Of Dammam, Dammam, Saudi Arabia.
authors.forename: Majed
authors.initials: M
authors.lastname: Alabdali
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Qrimli
authors.affiliation: Department of Neurology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Hana
authors.initials: H
authors.lastname: Albulaihe
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Ari
authors.initials: A
authors.lastname: Breiner
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Carolina
authors.initials: C
authors.lastname: Barnett
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Hans D
authors.initials: HD
authors.lastname: Katzberg
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai, Hospital and Lunenfeld Tanenbaum Research Institute, University of Toronto, Toronto, Canada.
authors.forename: Leif E
authors.initials: LE
authors.lastname: Lovblom
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai, Hospital and Lunenfeld Tanenbaum Research Institute, University of Toronto, Toronto, Canada.
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Perkins
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Vera
authors.initials: V
authors.lastname: Bril
mesh_terms: D003920:Diabetes Mellitus / Q000628:therapy*; D006801:Humans; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000150:complications* / Q000628:therapy*; D012372:ROC Curve; D012955:Societies, Medical; D016896:Treatment Outcome