title: The presumed central nervous system effects of rocuronium in a neonate and its reversal with sugammadex.
abstract: We describe a 2-day-old male infant who received rocuronium as part of general anesthesia for a tracheal esophageal fistula repair. Postoperatively, he had prolonged central and peripheral neuromuscular blockade despite cessation of the rocuronium infusion several hours previously. This case discusses the presumed central nervous system effects of rocuronium in a neonate and its effective reversal with sugammadex.
authors.affiliation: Paediatric Intensive Care Unit, Royal Hospital for Sick Children, Edinburgh, UK.
authors.forename: Ross J
authors.initials: RJ
authors.lastname: Langley
authors.affiliation: Paediatric Intensive Care Unit, Royal Hospital for Sick Children, Edinburgh, UK.
authors.forename: Jillian
authors.initials: J
authors.lastname: McFadzean
authors.affiliation: Paediatric Intensive Care Unit, Royal Hospital for Sick Children, Edinburgh, UK.|Department of Paediatric Anaesthesia, Royal Hospital for Sick Children, Edinburgh, UK.
authors.forename: Jon
authors.initials: J
authors.lastname: McCormack
mesh_terms: D000732:Androstanols / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium
keywords: blood-brain barrier; neonate; rocuronium; sugammadex