title: A novel inclusion complex (β-CD/ABP-dHC-cecropin A) with antibiotic propertiess for use as an anti-Agrobacterium additive in transgenic poplar rooting medium.
abstract: The increasing resistance of bacteria and fungi to currently available antibiotics is a major concern worldwide, leading to enormous effort to develop novel antibiotics with new modes of action.We recently reported that ABP-dHC-cecropin A exhibited strong antibacterial and antifungal activity, making it a candidate antibiotic substitute. In this study, β-cyclodextrin (β-CD) combined with ABP-dHC-cecropin A enhanced the physical and chemical properties of ABP-dHC-cecropin A but did not significantly decrease its antibacterial activity. Thus, β-CD/ABP-dHC-cecropin A should be considered a novel antibacterial drug. We used β-CD/ABP-dHC-cecropin A as an anti-Agrobacterium compound to supplementtransgenic poplar medium. Sideeffects of the inclusion complex had little impact on plantgrowth. Thus, β-CD/ABP-dHC-cecropin A may be used as traditional antibiotics forpoplar transplantation with greater antibbacterial effects.
authors.affiliation: Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing 210037, China.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province 311121, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing 210037, China.
authors.forename: Ali
authors.initials: A
authors.lastname: Movahedi
authors.affiliation: Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing 210037, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Sang
authors.affiliation: Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing 210037, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.affiliation: Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing 210037, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Xu
authors.affiliation: Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing 210037, China.
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing 210037, China.
authors.forename: Tongming
authors.initials: T
authors.lastname: Yin
authors.affiliation: Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing 210037, China. Electronic address: qzhuge@njfu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhuge
mesh_terms: D060054:Agrobacterium / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology*; D004355:Drug Stability; D010935:Plant Diseases / Q000382:microbiology / Q000517:prevention & control; D018517:Plant Roots / Q000187:drug effects / Q000254:growth & development / Q000382:microbiology; D030821:Plants, Genetically Modified; D032107:Populus / Q000187:drug effects* / Q000254:growth & development / Q000382:microbiology*; D013053:Spectrophotometry; D013816:Thermodynamics; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D047392:beta-Cyclodextrins; C031161:cecropin A; C031215:betadex
keywords: ABP-dHC-cecropin A; Antibacterial assay; Inclusion complex; Plant tissue culture medium additives; Stable Physicochemical property; β-Cyclodextrin