title: Voriconazole and posaconazole therapy for experimental Candida lusitaniae infection.
abstract: The in vitro activity of posaconazole (PSC) and voriconazole (VRC) was tested by using time-kill studies against 3 strains of Candida lusitaniae. Both drugs showed fungistatic activity against all strains. The efficacy of those compounds was evaluated by reducing kidney fungal burden and by determining (1→3)-β-d-glucan serum levels in a murine model of invasive infection of C. lusitaniae. The therapies tested were VRC at 10, 25, or 40 mg/kg/day and PSC at 5, 12.5, or 20 mg/kg/twice a day. All the dosages showed efficacy in a dose-dependant manner being high doses of both antifungals able to sterilize some kidneys after 10 days. With the exception of the strain FMR 9474, against which PSC was more effective than VRC, no differences in reducing tissue burden were found between the treatments. All doses of both antifungals were able to significantly reduce (1→3)-β-d-glucan serum levels with no significant differences between treatments and between the same doses of both drugs.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Sanchis
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
authors.affiliation: Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.affiliation: Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.affiliation: Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Nathan
authors.initials: N
authors.lastname: Wiederhold
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain. Electronic address: javier.capilla@urv.cat.
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D011509:Proteoglycans; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole / Q000008:administration & dosage*; D047071:beta-Glucans / Q000097:blood
chemical_list: D000935:Antifungal Agents; D011509:Proteoglycans; D014230:Triazoles; D047071:beta-Glucans; C010770:polysaccharide-K; C101425:posaconazole; D065819:Voriconazole
keywords: Animal model; Antifungal; Candida lusitaniae; Fungal infections; Posaconazole; Voriconazole