title: In vivo observation of the pH alternation in mitochondria for various external stimuli.
abstract: The pH of mitochondria (pHm) has a close relationship with many biological processes. Here we developed a new indicator Mito-pH-1 for the ratiometric fluorescence detection of the mitochondria pH value, which has excellent tolerance to environmental change. And Mito-pH-1 has been used for the first time to monitor the change of pHm under temperature and H2O2 stimuli in living cells.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. gqyang@iccas.ac.cn shayuli@iccas.ac.cn.
authors.forename: Lixia
authors.initials: L
authors.lastname: Cao
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. gqyang@iccas.ac.cn shayuli@iccas.ac.cn.
authors.forename: Zhensheng
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. gqyang@iccas.ac.cn shayuli@iccas.ac.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. gqyang@iccas.ac.cn shayuli@iccas.ac.cn.
authors.forename: Xudong
authors.initials: X
authors.lastname: Guo
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. gqyang@iccas.ac.cn shayuli@iccas.ac.cn.
authors.forename: Shuangqing
authors.initials: S
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. gqyang@iccas.ac.cn shayuli@iccas.ac.cn.
authors.forename: Shayu
authors.initials: S
authors.lastname: Li
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China. yili@mail.ipc.ac.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. gqyang@iccas.ac.cn shayuli@iccas.ac.cn.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yang
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D013050:Spectrometry, Fluorescence