title: NAP1L1-MLLT10 is a rare recurrent translocation that is associated with HOXA activation and poor treatment response in T-cell acute lymphoblastic leukaemia.
authors.affiliation: Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France.|Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bond
authors.affiliation: Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France.|Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Touzart
authors.affiliation: Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France.|Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
authors.forename: Agata
authors.initials: A
authors.lastname: Cieslak
authors.affiliation: Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France.|Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Trinquand
authors.affiliation: Department of Haematology, University Hospital and INSERM UMR 917, Rennes 1 University, Rennes, France.
authors.forename: Tony
authors.initials: T
authors.lastname: Marchand
authors.affiliation: Department of Haematology, University Hospital and INSERM UMR 917, Rennes 1 University, Rennes, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Escoffre
authors.affiliation: Department of Paediatric Haematology, University Hospital, Nancy, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Contet
authors.affiliation: Genetics Laboratory, University Hospital, Nancy, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Muller
authors.affiliation: Department of Paediatric Haematology, University Hospital, Nancy, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Schmitt
authors.affiliation: Department of Haematology, University Hospital and INSERM UMR 917, Rennes 1 University, Rennes, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Fest
authors.affiliation: Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France.|Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
authors.forename: Vahid
authors.initials: V
authors.lastname: Asnafi
authors.affiliation: Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France. elizabeth.macintyre@nck.aphp.fr.|Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France. elizabeth.macintyre@nck.aphp.fr.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Macintyre
mesh_terms: D000293:Adolescent; D000328:Adult; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D018447:Medical Futility; D056490:Nucleosome Assembly Protein 1 / Q000235:genetics*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic; D055815:Young Adult
chemical_list: D018398:Homeodomain Proteins; C092513:MLLT10 protein, human; C533557:NAP1L1 protein, human; D056490:Nucleosome Assembly Protein 1; D014157:Transcription Factors; C097899:homeobox protein HOXA9
keywords: HOXA; acute leukaemia; biology; clinical aspects; leukaemia cytogenetics