title: The potential role of activin and follistatin in lung transplant dysfunction.
abstract: Activin A, a member of the transforming growth factor β super-family, is a key regulator of multiple biological pathways including the physiological processes of organ development and homeostasis; as well as the pathological processes of inflammation, remodelling and fibrosis. Dysregulation of activin A and its naturally occurring antagonist follistatin, contribute to the development of disease in multiple organ systems. In this review, we summarize the regulation of activin A, its dysregulated expression in a number of respiratory diseases and postulate its potential role in contributing to allograft dysfunction following lung transplantation.
authors.affiliation: a Lung Transplant Service , Alfred Hospital and Monash University , Melbourne , Australia.|b St Vincent's Hospital Clinical School , University of Melbourne , Fitzroy , Australia.
authors.forename: James N
authors.initials: JN
authors.lastname: Snell
authors.affiliation: a Lung Transplant Service , Alfred Hospital and Monash University , Melbourne , Australia.
authors.forename: Glen P
authors.initials: GP
authors.lastname: Westall
authors.affiliation: a Lung Transplant Service , Alfred Hospital and Monash University , Melbourne , Australia.
authors.forename: Gregory I
authors.initials: GI
authors.lastname: Snell
mesh_terms: D028341:Activins / Q000502:physiology*; D000818:Animals; D038681:Follistatin / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008171:Lung Diseases / Q000503:physiopathology*; D016040:Lung Transplantation
chemical_list: D038681:Follistatin; C422405:activin A; D028341:Activins
keywords: Ischemia reperfusion injury; activin; allograft rejection; chronic lung allograft dysfunction; follistatin; inflammation; lung transplantation