title: Triphenylamine-based Schiff bases as the High sensitive Al(3+) or Zn(2+) fluorescence turn-on probe: Mechanism and application in vitro and in vivo.
abstract: Two novel similar structural triphenylamine-based Schiff base fluorescent probes (L1/L2) were designed, prepared and characterized. Distinctive recognition mechanisms of L1 and L2 toward Al(3+) and Zn(2+) have been established by UV/vis, fluorescence spectra, mass spectra and (1)H NMR studies, respectively. To further explore their utility in biological system, L2 was selected as a probe for live cell endogenous Zn(2+) indicator and showed superb sensitivity on Zn(2+) intracellular distribution. Furthermore, L2 was employed to selectively detect Zn(2+) in live tissues at both extracellular and intracellular level, qualitatively indicated varies zinc concentration as a function of different organs.
authors.affiliation: College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, 230601 Hefei, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: School of Life Science, Anhui University, Hefei 230601, PR China. Electronic address: t.xiaohe731@gmail.com.
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Tian
authors.affiliation: School of Life Science, Anhui University, Hefei 230601, PR China.
authors.forename: Bei
authors.initials: B
authors.lastname: Huang
authors.affiliation: College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, 230601 Hefei, PR China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, 230601 Hefei, PR China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Pharmacology, Basic Medical college, Anhui medical university, Hefei 230032, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.affiliation: Center of Modern Experimental Technology, Anhui University, Hefei 230039, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Center of Modern Experimental Technology, Anhui University, Hefei 230039, PR China.
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, 230601 Hefei, PR China. Electronic address: zhpzhp@263.net.
authors.forename: Hongping
authors.initials: H
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, 230601 Hefei, PR China.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Tian
authors.affiliation: College of Chemistry and Chemical Engineering, Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, 230601 Hefei, PR China.
authors.forename: Jieying
authors.initials: J
authors.lastname: Wu
mesh_terms: D000535:Aluminum / Q000032:analysis / Q000378:metabolism*; D002460:Cell Line; D005347:Fibroblasts / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles; D015203:Reproducibility of Results; D012545:Schiff Bases / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D015032:Zinc / Q000032:analysis / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D012545:Schiff Bases; D000535:Aluminum; D015032:Zinc
keywords: Aluminum ion; Biological application; Fluorescence probes; Recognition mechanisms; Zinc ion