title: The effects of resistance exercise in patients with knee osteoarthritis: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To analyze the effectiveness of resistance exercise in the treatment of knee osteoarthritis on pain, stiffness, and physical function.
  
  
  METHODS
  Systematic review and meta-analysis of randomized controlled trials.
  
  
  METHODS
  PubMed, Embase, Cochrane Central Register of Controlled Trials, the Web of Science, and Chinese Biomedical Literature Database were searched from the date of inception to August 2015.
  
  
  METHODS
  Trials comparing effects of resistance exercise intervention with either non-intervention or psycho-educational intervention were selected by two reviewers independently. The risk of bias was assessed and studies with similar outcomes were pooled using a fixed or random effects model.
  
  
  RESULTS
  Data from 17 randomized clinical trials including 1705 patients were integrated. The main source of methodological bias in the selected studies was lack of double blinding. The meta-analysis results suggested that resistance exercise training relieved pain (standard mean difference [SMD]: -0.43; 95% confidence interval [CI]: -0.57 to -0.29; P < 0.001), alleviated stiffness (SMD: -0.31; 95%: CI -0.56 to -0.05; P = 0.02), and improved physical function (SMD -0.53; 95% CI: -0.70 to -0.37; P < 0.001).
  
  
  CONCLUSIONS
  Resistance exercise is beneficial in terms of reducing pain, alleviating stiffness, and improving physical function in patients with knee osteoarthritis.
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China suyouxin777@hotmail.com.
authors.forename: Youxin
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Ziyi
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Changyan
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Meili
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Feiwen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Yiru
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Zhengxuan
authors.initials: Z
authors.lastname: Zhan
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Rehabilitation Medicine College, Fujian University of Traditional Chinese Medicine, Fujian, China.
authors.forename: Naixi
authors.initials: N
authors.lastname: Zheng
mesh_terms: D006801:Humans; D020370:Osteoarthritis, Knee / Q000534:rehabilitation*; D055070:Resistance Training
keywords: Resistance exercise; knee osteoarthritis; meta-analysis; pain