title: The ongoing quest for biomarkers in Ankylosing Spondylitis.
abstract: Ankylosing Spondylitis poses significant challenges in terms of early diagnosis, assessment of disease activity, predicting response to the treatment and monitoring radiographic progression. With better understanding of underlying immunopathogenesis, effective targeted therapies are available which improve symptoms, quality of life and possibly slow the radiographic progression. There has been a growing interest in the discovery of biomarkers for defining various aspects of disease assessment and management in Ankylosing Spondylitis. The C-reactive protein and HLA-B27 are most commonly used biomarkers. This review describes many other newer biomarkers which have potential clinical applications in this chronic inflammatory disease.
authors.affiliation: Division of Rheumatology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
authors.forename: Abhijeet
authors.initials: A
authors.lastname: Danve
authors.affiliation: Division of Rheumatology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
authors.forename: James
authors.initials: J
authors.lastname: O'Dell
mesh_terms: D000626:Aminopeptidases / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D020219:Chondrogenesis; D018450:Disease Progression; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015778:Minor Histocompatibility Antigens; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis; D011859:Radiography; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics / Q000276:immunology
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D015796:HLA-B27 Antigen; D018836:Inflammation Mediators; D015778:Minor Histocompatibility Antigens; D000626:Aminopeptidases; C464841:ERAP1 protein, human
keywords: ankylosing spondylitis; biomarker; disease activity; inflammatory bowel disease; radiographic progression