title: [Polymorphisms of IL-23 receptor gene are associated with susceptibility to pulmonary tuberculosis and drug-resistant pulmonary tuberculosis].
abstract: OBJECTIVE
  To explore the associations of interleukin-23 (IL-23) receptor gene polymorphisms, susceptibility to pulmonary tuberculosis and drug-resistant pulmonary tuberculosis (TB).
  
  
  METHODS
  For this paired case-control study, 13 single nucleotide polymorphisms (SNPs) in IL-23R gene were genotyped by multiplex SNaPshot with samples from 250 pairs of culture positive pulmonary TB patients and healthy controls. And the relationship between genotype, allele, haplotype and susceptibility to pulmonary tuberculosis was analyzed.
  
  
  RESULTS
  Two SNPs of IL-23R gene (rs10889677 and rs7518660) (OR = 1.53, 95% CI: 1.01-2.31; OR = 6.25, 95% CI: 3.85-10.00) were significantly associated with susceptibility to pulmonary TB and one SNP (rs11465802) (OR = 2.90; 95% CI: 1.69-4.98) was associated with drug-resistant pulmonary TB in the Chinese Uygur population.
  
  
  CONCLUSIONS
  Two SNPs of IL-23R gene, rs10889677 and rs7518660, may be the risk factors of pulmonary tuberculosis. And rs11465802 may be a risk factor of drug-resistant pulmonary tuberculosis in Chinese Uygur population.
authors.affiliation: Department of Pulmonology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Daobin
authors.initials: D
authors.lastname: Jiang
authors.affiliation: Department of Pulmonology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Pulmonology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Pulmonology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Abudoujilili
authors.initials: A
authors.lastname: Julaiti
authors.affiliation: Department of Pulmonology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Department of Pulmonology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pulmonology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China; Email: qimenw@hotmail.com.
authors.forename: Qimanguli
authors.initials: Q
authors.lastname: Wushouer
mesh_terms: D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D024881:Drug Resistance, Bacterial; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic; D018123:Receptors, Interleukin; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin