title: Self-sacrificial template-induced modulation of conjugated microporous polymer microcapsules and shape-dependent enhanced photothermal efficiency for ablation of cancer cells.
abstract: The one-step synthesis of nanoscale conjugated microporous polymer (NCMP) capsules is presented by using PMAA microspheres as self-sacrificial templates. Precise control over the morphology, nanostructure and shell thickness makes the NCMPs have a tunable NIR absorption ability and a shape-dependent photothermal conversion efficiency. Upon exposure to 808 nm light, they rapidly generate heat (NCMP concentration: 100 μg mL(-1)) and cause thermal ablation of HeLa cells with less than 10% viability.
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China. guojia@fudan.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Tan
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China. guojia@fudan.edu.cn.
authors.forename: Jiaxun
authors.initials: J
authors.lastname: Wan
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China. guojia@fudan.edu.cn.
authors.forename: Jia
authors.initials: J
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China. guojia@fudan.edu.cn.
authors.forename: Changchun
authors.initials: C
authors.lastname: Wang
mesh_terms: D055011:Ablation Techniques; D000178:Acrylamides / Q000737:chemistry; D002384:Catalysis; D002470:Cell Survival; D003300:Copper; D052203:Ferrosoferric Oxide / Q000737:chemistry; D057809:HEK293 Cells; D006367:HeLa Cells; D006461:Hemolysis; D006358:Hot Temperature; D006801:Humans; D007834:Lasers; D008027:Light; D060526:Magnetic Fields; D008863:Microspheres; D057145:Nanoshells / Q000737:chemistry*; D010165:Palladium; D010789:Phototherapy; D011109:Polymethacrylic Acids / Q000737:chemistry*; D016062:Porosity
chemical_list: D000178:Acrylamides; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D010165:Palladium; D003300:Copper; C021221:N,N'-methylenebisacrylamide; D052203:Ferrosoferric Oxide