title: STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan.
abstract: Neuroinflammation is emerging as an important pathway involved in Parkinson's disease (PD) pathogenesis. Herein, we investigated the effect of 4 top PD-associated genetic variants in Caucasians listed on the top risk loci identified by meta-analysis of genome wide-association studies in PDGene database (http://www.pdgene.org/top_results), including serine threonine kinase 39 (STK39) rs1955337, bone marrow stromal cell antigen 1 (BST1) rs11724635, major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) rs9275326, and signal peptide peptidase-like 2B (SPPL2B) rs62120679, by genotyping 596 Han-Chinese patients with PD and 597 age-matched control subjects. Compared with subjects with STK39 rs1955337 GG genotype, those with TT genotype had a 1.64-fold increased risk of PD (95% confidence interval: 1.13-2.39, P = 0.010). The recessive model also demonstrated an increased PD risk in TT genotype (odds ratio: 1.59, 95% confidence interval: 1.12-2.27) compared with the other genotypes (GT + GG). PD patients demonstrate a similar genotypic and allelic frequency in BST1 rs11724635, HLA-DQB1 rs9275326, and SPPL2B rs62120679 compared with controls. These findings suggested that the STK39 rs1955337 TT genotype is a risk factor for Han-Chinese patients with PD in Taiwan. The ethnic discrepancies of the other 3 genetic variants may indicate a distinct genetic background of neuroinflammation between PD patients in Han-Chinese and Caucasians.
authors.affiliation: From the Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine (K-HC, Y-RW, Y-CC, H-CF, C-MC); and Department of Life Science, National Taiwan Normal University, Taipei, Taiwan (C-JL-C).
authors.forename: Kuo-Hsuan
authors.initials: KH
authors.lastname: Chang
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Wu
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Hon-Chung
authors.initials: HC
authors.lastname: Fung
authors.forename: Guey-Jen
authors.initials: GJ
authors.lastname: Lee-Chen
authors.forename: Chiung-Mei
authors.initials: CM
authors.lastname: Chen
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D016282:Aspartic Acid Endopeptidases / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D058851:GPI-Linked Proteins / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059866:HLA-DQ beta-Chains / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D017346:Protein Serine-Threonine Kinases; C486409:STK39 protein, human; D036541:ADP-ribosyl Cyclase; C087521:ADP-ribosyl cyclase 2; D016282:Aspartic Acid Endopeptidases; C526456:SPPL2b protein, human