title: Current State of ERG as Biomarker in Prostatic Adenocarcinoma.
abstract: In this review we briefly discuss the possible biomarkers of prostate cancer among them we focus and analyze the relevance of TMPRSS2-ERG fusion gene in line with ERG expression in the diagnosis of prostate cancer. Starting at diagnosis and genetic alterations in prostate carcinomas, we examine the incidence and detection of the most common genetic aberration in this tumor and its protein product as well. We also examined the correlation of clinicopathological factors and prognosis with ERG and the TMPRSS2-ERG fusion oncogene and ERG expression as predictive markers.
authors.forename: Balazs
authors.initials: B
authors.lastname: Acs
authors.forename: Tibor
authors.initials: T
authors.lastname: Szarvas
authors.forename: Nora
authors.initials: N
authors.lastname: Szekely
authors.forename: Peter
authors.initials: P
authors.lastname: Nyirady
authors.affiliation: 2nd Department of Pathology, Semmelweis University Budapest, 93 Ulloi ut, Budapest 1091, Hungary. cac@korb2.sote.hu.
authors.forename: A Marcell
authors.initials: AM
authors.lastname: Szasz
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D014408:Biomarkers, Tumor; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D015534:Trans-Activators / Q000032:analysis*; D000071230:Transcriptional Regulator ERG
chemical_list: D014408:Biomarkers, Tumor; C072312:ERG protein, human; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG