title: Plasmonic Nanohole Sensor for Capturing Single Virus-Like Particles toward Virucidal Drug Evaluation.
abstract: A plasmonic nanohole sensor for virus-like particle capture and virucidal drug evaluation is reported. Using a materials-selective surface functionalization scheme, passive immobilization of virus-like particles only within the nanoholes is achieved. The findings demonstrate that a low surface coverage of particles only inside the functionalized nanoholes significantly improves nanoplasmonic sensing performance over conventional nanohole arrays.
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.|Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Jackman
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.|Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore.
authors.forename: Eric
authors.initials: E
authors.lastname: Linardy
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, 200 Union Street SE, Minneapolis, MN, 55455, USA.
authors.forename: Daehan
authors.initials: D
authors.lastname: Yoo
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.|Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore.
authors.forename: Jeongeun
authors.initials: J
authors.lastname: Seo
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.|Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore.
authors.forename: Wei Beng
authors.initials: WB
authors.lastname: Ng
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, 200 Union Street SE, Minneapolis, MN, 55455, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Klemme
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, 200 Union Street SE, Minneapolis, MN, 55455, USA.
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Wittenberg
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, 200 Union Street SE, Minneapolis, MN, 55455, USA.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Oh
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.|Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore.|School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore.
authors.forename: Nam-Joon
authors.initials: NJ
authors.lastname: Cho
mesh_terms: D000327:Adsorption; D000998:Antiviral Agents / Q000494:pharmacology*; D015374:Biosensing Techniques / Q000379:methods*; D003716:Dengue Virus / Q000187:drug effects*; D004341:Drug Evaluation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D017433:Protein Structure, Secondary; D014771:Virion / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D010455:Peptides
keywords: biosensing; peptides; plasmonics; sensors, biosensors, nanohole arrays; viruses