title: [The role of developmental HOX genes in cervical cancer].
abstract: Cervical cancer (CC) is a multifactorial disease associated to genetic, environmental and epigenetic factors, being the infection by human papillomavirus the main etiologic agent. Additionally, the alteration in the expression of transcription factors has been considered of importance for the development of this tumor. HOX genes encode a group of transcription factors involved in cellular proliferation and differentiation processes during the development of embryonic structures in vertebrates; their aberrant expression is associated with tumorigenesis and metastasis. A range of evidence suggests a role for HOX genes in the development of cervical neoplastic cell. Studies in CC cell lines, primary tumors and premalignant lesions have suggested the involvement of HOXA1, HOXC5, C6, C8 and C10, HOXD9 and HOXD13 in the process of cervical carcinogenesis. Also, the de novo expression of genes HOXB2, B4, B13 and HOXC11-C13 appears to be involved in the process of malignant transformation of cervical epithelial cell. These data would allow to open a field in search of new molecular markers in cervical cancer and the development of new therapeutic strategies for this malignancy.
authors.affiliation: Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. rlopez_99@yahoo.com.
authors.forename: Ricardo
authors.initials: R
authors.lastname: López-Romero
authors.forename: Daniel
authors.initials: D
authors.lastname: Marrero-Rodríguez
authors.forename: Pablo
authors.initials: P
authors.lastname: Romero-Morelos
authors.forename: Vanessa
authors.initials: V
authors.lastname: Villegas
authors.forename: Alejandra
authors.initials: A
authors.lastname: Valdivia
authors.forename: Hugo
authors.initials: H
authors.lastname: Arreola
authors.forename: Víctor
authors.initials: V
authors.lastname: Huerta-Padilla
authors.forename: Mauricio
authors.initials: M
authors.lastname: Salcedo
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D063646:Carcinogenesis / Q000235:genetics; D005260:Female; D005801:Genes, Homeobox; D005819:Genetic Markers; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers
keywords: Homeobox genes; Uterine cervical neoplasms