title: Transcutaneous carbon dioxide during sleep-disordered breathing.
abstract: Respiratory drive is tightly controlled by the carbon dioxide levels. We tested the hypothesis that sequences of sleep apnoea (obstructive, central or mixed), hypopnoea and flow limitation are characterized by different levels of transcutaneous CO2 (PtcCO2). Polygraphic recordings (n=555) from patients with suspected sleep-disordered breathing (SDB) were retrospectively screened to find sequences (5 min or 10 events) of both SDB and steady breathing. Eighty-eight SDB sequences from 44 patients were included and PtcCO2 and SpO2 values were collected. PtcCO2 values during sequences were normalized by setting wakefulness level as 100%. In terms of PtcCO2, apnoea sequences with central component (central (n=7) and mixed (n=3) apnoea) did not differ from wakefulness (102.0% vs 100%, p=0.122) whereas obstructive apnoea (105.8%, p<0.001) and hypopnoea did (105.4%, p<0.001). PtcCO2 during flow limitation was higher than that during any other sequence, including steady breathing (112.2% vs 108.4%, p=0.022). Continuous PtcCO2 monitoring during sleep adds to the understanding of different SDB phenotypes.
authors.affiliation: School of Medicine, University of Tampere, Finland; Unesta Research Center, Tampere, Finland. Electronic address: rimpila.ville.p@student.uta.fi.
authors.forename: Ville
authors.initials: V
authors.lastname: Rimpilä
authors.affiliation: Unesta Research Center, Tampere, Finland.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hosokawa
authors.affiliation: School of Health Sciences, University of Tampere, Finland.
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.affiliation: Division of Medicine, Department of Pulmonary Diseases, Turku University Hospital, and Department of Pulmonary Diseases and Clinical Allergology and Sleep Research Centre, Department of Physiology, University of Turku, Finland.
authors.forename: Tarja
authors.initials: T
authors.lastname: Saaresranta
authors.affiliation: School of Medicine, University of Tampere, Finland; Unesta Research Center, Tampere, Finland.
authors.forename: Aaro V
authors.initials: AV
authors.lastname: Salminen
authors.affiliation: Unesta Research Center, Tampere, Finland; Department of Respiratory Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland.
authors.forename: Olli
authors.initials: O
authors.lastname: Polo
mesh_terms: D001785:Blood Gas Monitoring, Transcutaneous; D002245:Carbon Dioxide / Q000032:analysis*; D005260:Female; D006801:Humans; D001239:Inhalation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000378:metabolism*; D014851:Wakefulness / Q000502:physiology
chemical_list: D002245:Carbon Dioxide
keywords: Apnoea; Carbon dioxide; Flow limitation; Sleep; Transcutaneous