title: Enzyme-regulated topology of a cyclic peptide brush polymer for tuning assembly.
abstract: Norbornenyl cyclic elastin-like peptides were polymerized via ring opening metathesis polymerization (ROMP) to generate thermally responsive brush polymers. The thermally-responsive nature of the materials could be attenuated by the addition of a proteolytic enzyme that causes the cyclic peptide side chains to be linearized.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. ngianneschi@ucsd.edu.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. ngianneschi@ucsd.edu.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. ngianneschi@ucsd.edu and Materials Science and Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
authors.forename: Yuran
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. ngianneschi@ucsd.edu.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Thompson
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. ngianneschi@ucsd.edu.
authors.forename: Clare L M
authors.initials: CL
authors.lastname: LeGuyader
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. ngianneschi@ucsd.edu.
authors.forename: Swagat
authors.initials: S
authors.lastname: Sahu
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. ngianneschi@ucsd.edu and Materials Science and Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Gianneschi
mesh_terms: D008823:Micelles; D010447:Peptide Hydrolases / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000378:metabolism*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D013696:Temperature
chemical_list: D008823:Micelles; D010456:Peptides, Cyclic; D011108:Polymers; D010447:Peptide Hydrolases