title: Cytokines and MicroRNAs as Candidate Biomarkers for Systemic Lupus Erythematosus.
abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, with varied course and symptoms. Its etiology is very complex and not clearly understood. There is growing evidence of the important role of cytokines in SLE pathogenesis, as well as their utility as biomarkers and targets in new therapies. Other potential new SLE biomarkers are microRNAs. Recently, over one hundred different microRNAs have been demonstrated to have a significant impact on the immune system. Various alterations in these microRNAs, associated with disease pathogenesis, have been described. They influence the signaling pathways and functions of immune response cells. Here, we aim to review the emerging new data on SLE etiology and pathogenesis.
authors.affiliation: Department of Biochemistry and Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw 02-637, Poland. barbara.stypinska@wp.pl.
authors.forename: Barbara
authors.initials: B
authors.lastname: Stypińska
authors.affiliation: Department of Biochemistry and Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw 02-637, Poland. kancelaria@ir.ids.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Paradowska-Gorycka
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D015415:Biomarkers / Q000097:blood*; D016207:Cytokines / Q000097:blood* / Q000235:genetics / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015415:Biomarkers; D016207:Cytokines; D035683:MicroRNAs
keywords: SLE; biomarkers; cytokines; microRNA