title: Effects of RHAMM/HMMR-Selective Peptides on Survival of Breast Cancer Cells.
abstract: RHAMM-selective peptides in a concentration of 10 μg/ml (2×10(-7) M) inhibited the growth of MDA-MB-231 breast cancer cells over 48 h. Treatment of cancer cells with RHAMM-selective peptides induced apoptosis and necrosis and increased caspase-3 activity (by 30%).
authors.affiliation: Institute of Chemical Physics Problems, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia. na_aken@icp.ac.ru.
authors.forename: N P
authors.initials: NP
authors.lastname: Akent'eva
authors.affiliation: Research Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Shushanov
authors.affiliation: Institute of Chemical Physics Problems, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Kotel'nikov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016326:Extracellular Matrix Proteins / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009336:Necrosis / Q000139:chemically induced; D010078:Oxazines; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D014966:Xanthenes
chemical_list: D000970:Antineoplastic Agents; D016326:Extracellular Matrix Proteins; D018960:Hyaluronan Receptors; D010078:Oxazines; D010455:Peptides; D014966:Xanthenes; C098946:hyaluronan-mediated motility receptor; C005843:resazurin; C505407:CASP3 protein, human; D053148:Caspase 3
keywords: RHAMM-selective peptides; RHAMM/HMMR (hyaluronan-mediated motility receptor); apoptosis; breast cancer; necrosis