title: Rational design of a degradable polyanion for layer-by-layer assembly for encapsulation and release of cationic functional biomolecules.
abstract: A novel degradable polyanion, poly(phthalic ethylene glycol ester), was synthesized in one pot in a single step. The degradable polyanion assembles with various polycations to form layer-by-layer films that can encapsulate physiologically active biomolecules. Polyanion degradation can induce film disassembly and release of the encapsulated functional protein.
authors.affiliation: Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe 657-8501, Japan. tmarutcm@crystal.kobe-u.ac.jp.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Hiraoka
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Funasaki
authors.forename: Jun
authors.initials: J
authors.lastname: Ishii
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D000327:Adsorption; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002417:Cattle; D048271:Chitosan / Q000737:chemistry; D045304:Cytochromes c / Q000737:chemistry; D004339:Drug Compounding; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D006367:HeLa Cells; D006736:Horses; D006801:Humans; D006868:Hydrolysis; D009113:Muramidase / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012259:Ribonuclease, Pancreatic / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D005456:Fluorescent Dyes; C000610075:poly(phthalic ethylene glycol ester); D011092:Polyethylene Glycols; D045304:Cytochromes c; D048271:Chitosan; D012259:Ribonuclease, Pancreatic; D009113:Muramidase; D016650:Fluorescein-5-isothiocyanate