title: Melatonin for sleep problems in children with neurodevelopmental disorders.
abstract: Children with neurodevelopmental disorders are at risk of sleep problems, typically difficulty getting to sleep, sleep/wake rhythm disturbances and reduced duration of sleep (insomnia). This may be associated with abnormally timed or inadequate secretion of melatonin, a naturally-occurring hormone involved in coordinating the body's sleep-wake cycle. Previously, we reviewed the use of a melatonin product licensed for primary insomnia in adults aged over 55 years. Here we review off-label and unlicensed use of melatonin in children with attention-deficit hyperactivity disorder (ADHD) or autism spectrum disorder or related neurodevelopmental disorders.
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000188:drug therapy; D000067877:Autism Spectrum Disorder / Q000150:complications / Q000188:drug therapy; D002648:Child; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D008550:Melatonin / Q000627:therapeutic use*; D065886:Neurodevelopmental Disorders / Q000150:complications / Q000188:drug therapy*; D056687:Off-Label Use; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D006993:Hypnotics and Sedatives; D008550:Melatonin