title: Multifunctional Hydrogel with Good Structure Integrity, Self-Healing, and Tissue-Adhesive Property Formed by Combining Diels-Alder Click Reaction and Acylhydrazone Bond.
abstract: Hydrogel, as a good cartilage tissue-engineered scaffold, not only has to possess robust mechanical property but also has to have an intrinsic self-healing property to integrate itself or the surrounding host cartilage. In this work a double cross-linked network (DN) was designed and prepared by combining Diels-Alder click reaction and acylhydrazone bond. The DA reaction maintained the hydrogel's structural integrity and mechanical strength in physiological environment, while the dynamic covalent acylhydrazone bond resulted in hydrogel's self-healing property and controlled the on-off switch of network cross-link density. At the same time, the aldehyde groups contained in hydrogel further promote good integration of the hydrogel to surrounding tissue based on aldehyde-amine Schiff-base reaction. This kind of hydrogel has good structural integrity, autonomous self-healing, and tissue-adhesive property and simultaneously will have a good application in tissue engineering and tissue repair field.
authors.affiliation: School of Materials Science and Engineering, South China University of Technology , Guangzhou 510641, P. R. China.|College of Materials and Chemical Engineering, Hainan University , Haikou 570228, P. R. China.|National Engineering Research Centre for Tissue Restoration and Reconstruction , Guangzhou 510006, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.affiliation: School of Materials Science and Engineering, South China University of Technology , Guangzhou 510641, P. R. China.|National Engineering Research Centre for Tissue Restoration and Reconstruction , Guangzhou 510006, P. R. China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Cao
authors.affiliation: College of Materials and Chemical Engineering, Hainan University , Haikou 570228, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Du
authors.affiliation: School of Materials Science and Engineering, South China University of Technology , Guangzhou 510641, P. R. China.|National Engineering Research Centre for Tissue Restoration and Reconstruction , Guangzhou 510006, P. R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, South China University of Technology , Guangzhou 510641, P. R. China.|National Engineering Research Centre for Tissue Restoration and Reconstruction , Guangzhou 510006, P. R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Chen
mesh_terms: D000269:Adhesives; D000818:Animals; D002356:Cartilage / Q000473:pathology; D057930:Click Chemistry / Q000379:methods*; D003432:Cross-Linking Reagents / Q000737:chemistry; D061565:Cycloaddition Reaction; D006820:Hyaluronic Acid / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D044367:Phase Transition; D011108:Polymers / Q000737:chemistry; D012964:Sodium / Q000737:chemistry; D013314:Stress, Mechanical; D013552:Swine; D000267:Tissue Adhesions; D014014:Tissue Adhesives; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000269:Adhesives; D003432:Cross-Linking Reagents; D006835:Hydrazones; D020100:Hydrogels; D011108:Polymers; D014014:Tissue Adhesives; D006820:Hyaluronic Acid; D012964:Sodium
keywords: Diels−Alder click chemistry; dynamic covalent chemistry; hydrogel; pH responsive; self-healing; tissue-adhesive