title: Differential hippocampal shapes in posterior cortical atrophy patients: A comparison with control and typical AD subjects.
abstract: Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by predominant visual deficits and parieto-occipital atrophy, and is typically associated with Alzheimer's disease (AD) pathology. In AD, assessment of hippocampal atrophy is widely used in diagnosis, research, and clinical trials; its utility in PCA remains unclear. Given the posterior emphasis of PCA, we hypothesized that hippocampal shape measures may give additional group differentiation information compared with whole-hippocampal volume assessments. We investigated hippocampal volume and shape in subjects with PCA (n = 47), typical AD (n = 29), and controls (n = 48). Hippocampi were outlined on MRI scans and their 3D meshes were generated. We compared hippocampal volume and shape between disease groups. Mean adjusted hippocampal volumes were ∼ 8% smaller in PCA subjects (P < 0.001) and ∼ 22% smaller in tAD subject (P < 0.001) compared with controls. Significant inward deformations in the superior hippocampal tail were observed in PCA compared with controls even after adjustment for hippocampal volume. Inward deformations in large areas of the hippocampus were seen in tAD subjects compared with controls and PCA subjects, but only localized shape differences remained after adjusting for hippocampal volume. The shape differences observed, even allowing for volume differences, suggest that PCA and tAD are each associated with different patterns of hippocampal tissue loss that may contribute to the differential range and extent of episodic memory dysfunction in the two groups.
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
authors.forename: Emily N
authors.initials: EN
authors.lastname: Manning
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
authors.forename: Kate E
authors.initials: KE
authors.lastname: Macdonald
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
authors.forename: Kelvin K
authors.initials: KK
authors.lastname: Leung
authors.affiliation: Centre for Medical Image Computing, University College London, London, United Kingdom.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Young
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
authors.forename: Tracey
authors.initials: T
authors.lastname: Pepple
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
authors.forename: Manja
authors.initials: M
authors.lastname: Lehmann
authors.affiliation: Centre for Medical Image Computing, University College London, London, United Kingdom.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Zuluaga
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.|Centre for Medical Image Computing, University College London, London, United Kingdom.
authors.forename: M Jorge
authors.initials: MJ
authors.lastname: Cardoso
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Schott
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.|Centre for Medical Image Computing, University College London, London, United Kingdom.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Ourselin
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Crutch
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
authors.forename: Nick C
authors.initials: NC
authors.lastname: Fox
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
authors.forename: Josephine
authors.initials: J
authors.lastname: Barnes
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology*; D001284:Atrophy / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
keywords: Alzheimer; Alzheimer's disease; PCA; atrophy; classifier; hippocampus; morphometry; shape; support vector machine