title: Alkene-Directed N-Attack Chemoselectivity in the Gold-Catalyzed [2+2+1]-Annulations of 1,6-Enynes with N-Hydroxyanilines.
abstract: Kinetically unstable nitrones are generated from gold-catalyzed reactions of 1,6-enynes with N-hydroxyanilines, and subsequently trapped by tethered alkenes to furnish [2+2+1]-annulations. Our experimental data reveal that such nitrones arise from atypical N-attack chemoselectivity that is triggered by tethered alkenes to facilitate the key protodeauration reaction.
authors.affiliation: Department of Chemistry, National Tsing-Hua University, Hsinchu, 30013 (Taiwan, ROC).
authors.forename: Deepak B
authors.initials: DB
authors.lastname: Huple
authors.affiliation: Department of Chemistry, National Tsing-Hua University, Hsinchu, 30013 (Taiwan, ROC).
authors.forename: Bhanudas D
authors.initials: BD
authors.lastname: Mokar
authors.affiliation: Department of Chemistry, National Tsing-Hua University, Hsinchu, 30013 (Taiwan, ROC). rsliu@mx.nthu.edu.tw.
authors.forename: Rai-Shung
authors.initials: RS
authors.lastname: Liu
keywords: N-attack; annulations; chemoselectivity; gold catalyst