title: Synthesis of Substituted Tropones by Sequential Rh-Catalyzed [5+2] Cycloaddition and Elimination.
abstract: Highly substituted tropones are prepared from cycloheptatrienes derived from Rh-catalyzed intermolecular [5+2] cycloaddition of 3-acyloxy-1,4-enynes and propargylic alcohols. The intermolecular [5+2] cycloaddition is highly regioselective for a variety of propargylic alcohols. Elimination of the cycloaddition products afforded various substituted tropones.
authors.affiliation: School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA.
authors.forename: Wangze
authors.initials: W
authors.lastname: Song
authors.affiliation: School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA ; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong Province, 510515, P. R. China.
authors.forename: Bao-Min
authors.initials: BM
authors.lastname: Xi
authors.affiliation: School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA.
authors.forename: Ka
authors.initials: K
authors.lastname: Yang
authors.affiliation: School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA ; Department of Chemistry, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Weiping
authors.initials: W
authors.lastname: Tang
keywords: 1,4-enynes; alkynes; cycloaddition; rhodium; tropone