title: Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients.
abstract: Neurosarcoidosis is a clinical subtype of sarcoidosis characterized by the presence of granulomas in the nervous system. Here, we report a highly significant association with a variant (rs75652600, P = 3.12 × 10(-8), odds ratios = 4.34) within a zinc finger gene, ZNF592, from an imputation-based fine-mapping study of the chromosomal region 15q25 in African-Americans with neurosarcoidosis. We validate the association with ZNF592, a gene previously shown to cause cerebellar ataxia, in a cohort of European-Americans with neurosarcoidosis by uncovering low-frequency variants with a similar risk effect size (chr15:85309284, P = 0.0021, odds ratios = 5.36).
authors.affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation Oklahoma City, Oklahoma ; Departments of Biostatistics, Harvard University Cambridge, Massachusetts.
authors.forename: Caleb A
authors.initials: CA
authors.lastname: Lareau
authors.affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation Oklahoma City, Oklahoma.
authors.forename: Indra
authors.initials: I
authors.lastname: Adrianto
authors.affiliation: Department of Public Health Services, Henry Ford Health System Detroit, Michigan ; Center for Bioinformatics, Henry Ford Health System Detroit, Michigan.
authors.forename: Albert M
authors.initials: AM
authors.lastname: Levin
authors.affiliation: Department of Medicine, Upstate Medical University Syracuse, New York.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Iannuzzi
authors.affiliation: Department of Public Health Services, Henry Ford Health System Detroit, Michigan.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Rybicki
authors.affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation Oklahoma City, Oklahoma.
authors.forename: Courtney G
authors.initials: CG
authors.lastname: Montgomery