title: Relationship between C242T polymorphism and arterial stiffness in an apparently healthy population.
abstract: Superoxide production is modulated by the C242T polymorphism of the CYBA gene. A major source of the superoxide anion that contributes to arterial stiffness is oxidase. We investigated the relationship between the C242T polymorphism and brachial-ankle pulse wave velocity (baPWV) in an apparently healthy population, while controlling for the amount of consumed cigarette. We measured baPWV non-invasively, recorded the detailed history of smoking and genotyped the C242T polymorphism in 856 participants. The CC genotype was related to a higher value of baPWV than the CT/TT genotype (1438.7±11.9 vs 1371.0±32.4 cm s(-1), β=-0.069, P=0.03) after adjustment for covariates. Further investigation showed an interaction between C242T polymorphism and smoking status with respect to baPWV (P<0.0001). For smokers, the CC genotype of C242T polymorphism was correlated with higher baPWV values compared with CT/TT genotype (1344.2±17.4 vs 1126.8±22.5 cm s(-1), β=-0.279, P<0.0001), whereas this relationship in the non-smokers was not significant (1485.5±15.1 vs 1499.0±41.5 cm s(-1), β=0.027, P=0.48). Additionally, for smokers who smoked at least 180 cigarette-years, the CC genotype participants showed higher values of baPWV compared with CT/TT polymorphism carriers (P⩽0.011). Our findings suggest that the C242T gene polymorphism is associated with arterial stiffness. Additionally, this relationship could be modified by smoking dose.
authors.affiliation: Department of Cardiology, Changzhou Second People's Hospital, Affiliated Nanjing Medical University, Changzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Department of Cardiology, Changzhou Second People's Hospital, Affiliated Nanjing Medical University, Changzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Ge
authors.affiliation: Department of Cardiology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Changzhou Second People's Hospital, Affiliated Nanjing Medical University, Changzhou, China.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Changzhou Second People's Hospital, Affiliated Nanjing Medical University, Changzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Changzhou Second People's Hospital, Affiliated Nanjing Medical University, Changzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Cao
mesh_terms: D055109:Ankle Brachial Index; D002681:China; D005260:Female; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D064368:Healthy Volunteers; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D059289:Vascular Stiffness / Q000235:genetics*
chemical_list: D019255:NADPH Oxidases; C086986:CYBA protein, human