title: Pulmonary hypertension in polymyositis.
abstract: Pulmonary hypertension (PH) is relatively common in connective tissue diseases. However, few studies have focused on the pulmonary hypertension (PH) associated with polymyositis (PM). Our aim is to investigate the prevalence of PH and determine the associated factors for PH in patients with PM. Multicenter study of 61 patients with PM underwent evaluation including general information, physical examination, laboratory indictors, thoracic high-resolution CT (HRCT) imaging, and transthoracic echocardiography (TTE). TTE was performed to estimate the pulmonary arterial pressure. PH was defined as resting systolic pulmonary artery pressure (sPAP) ≥40 mmHg. PH was identified in ten patients (16.39 %) who had few cardiopulmonary symptoms. PM patients with PH had higher prevalence of interstitial lung disease (ILD) and pericardial effusion (PE) compared with patients without PH (18 vs. 11.5 %, p = 0.005; 11.5 vs. 9.8 %, p = 0.004; respectively). After controlling for age, gender, and potential factors, ILD and PE were independently associated with PH in patients with PM in multivariate analysis (OR = 8.193, 95 % CI 1.241-54.084, p = 0.029; OR = 8.265, 95 % CI 1.298-52.084, p = 0.025; respectively). Depending on TTE, the possible prevalence of PH was 16.39 % in patients with PM. Both ILD and PE may contribute to the development of PH in PM.
authors.affiliation: Cardiovascular Disease Research Institute, The Third People's Hospital of Chengdu, 82 Qinlong St, Chengdu, Sichuan, 610031, People's Republic of China.
authors.forename: Han
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurology, People's Hospital of Hainan Province, 19 Xiuhua Road, Haikou, Hainan, 570311, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Geriatric, The First Affiliated Hospital of Chengdu Medical College, 278 Baoguang St, Chengdu, Sichuan, 610083, People's Republic of China.
authors.forename: Ying-ying
authors.initials: YY
authors.lastname: Cai
authors.affiliation: Cardiovascular Disease Research Institute, The Third People's Hospital of Chengdu, 82 Qinlong St, Chengdu, Sichuan, 610031, People's Republic of China.
authors.forename: Lian
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang St, Guangzhou, Guangdong, 510120, People's Republic of China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Cardiovascular Disease Research Institute, The Third People's Hospital of Chengdu, 82 Qinlong St, Chengdu, Sichuan, 610031, People's Republic of China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Yang
authors.affiliation: Cardiovascular Disease Research Institute, The Third People's Hospital of Chengdu, 82 Qinlong St, Chengdu, Sichuan, 610031, People's Republic of China. wh7967@hotmail.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000453:epidemiology*; D016015:Logistic Models; D008168:Lung / Q000000981:diagnostic imaging*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015999:Multivariate Analysis; D010490:Pericardial Effusion / Q000175:diagnosis / Q000453:epidemiology*; D017285:Polymyositis / Q000453:epidemiology*; D015995:Prevalence; D014057:Tomography, X-Ray Computed
keywords: Echocardiography; Interstitial lung disease; Pericardial effusion; Polymyositis; Pulmonary hypertension