title: Metal-free methylation of a pyridine N-oxide C-H bond by using peroxides.
abstract: Metal-free methylation of a pyridine N-oxide C-H bond was developed using peroxide as a methyl reagent under neat conditions. Pyridine N-oxide derivatives with various groups (e.g., Cl, NO2, and OCH3) were all suitable substrates, and the desired products were obtained in moderate to excellent yields under standard conditions. Moreover, the methylation can be performed with a good yield on the gram-scale experiment. Tentative mechanistic studies show that the methylation is a classical radical process.
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Suling
authors.initials: S
authors.lastname: Yang
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Bingjie
authors.initials: B
authors.lastname: Lv
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Han
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Xingxing
authors.initials: X
authors.lastname: Ma
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Yunhe
authors.initials: Y
authors.lastname: Lv
authors.affiliation: College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000 P. R. China. ligang@aynu.edu.cn wuhankui222@126.com.
authors.forename: Hankui
authors.initials: H
authors.lastname: Wu