title: Recurrent angio-fibroma of breast masquerading as phyllodes tumor.
abstract: A young Indian female presented with a recurring tumor in the right breast masquerading as phyllodes tumor. Patient had history of five times excision and recurrences of the tumor, diagnosed as fibrous phyllodes of the breast. Presently, a well-circumscribed tumor of about 10 cm size, comprising of benign fibrous-angiomatous tissue with evidence of foci of pyogenic vasculitis was observed. Immuno-histochemical markers for the myo-epithelial and epithelial elements excluded the possibility of fibrous phyllodes, inflammatory myofibroblastic tumor, desmoid fibromatosis, and metaplastic carcinoma. The present findings were diagnostic of an inflammatory angio-fibroma of the right breast, not reported in the earlier literature. The observations indicated that the female breast may be susceptible to spontaneous productive and common-antibiotic-resistant focal septic vascular inflammation giving rise to angio-fibromatous proliferation producing a well-defined tumor mass in the breast, distinguishable from the other breast lesions by the connective tissue stains and immuno-histochemical markers.
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh, Uttar Pradesh, India.
authors.forename: Jai K
authors.initials: JK
authors.lastname: Chaurasia
authors.forename: Feroz
authors.initials: F
authors.lastname: Alam
authors.forename: Mariam
authors.initials: M
authors.lastname: Shadan
authors.forename: Mohammed
authors.initials: M
authors.lastname: Naim
mesh_terms: D000293:Adolescent; D018322:Angiofibroma / Q000175:diagnosis* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000302:isolation & purification; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology; D003557:Phyllodes Tumor / Q000175:diagnosis / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor