title: The safety and effectiveness of HBV vaccination in patients with juvenile idiopathic arthritis controlled by treatment.
abstract: OBJECTIVE
  To evaluate the safety and effectiveness of hepatitis B virus (HBV) vaccination in patients with juvenile idiopathic arthritis (JIA) controlled by treatment.
  
  
  METHODS
  Among 49 patients with juvenile idiopathic arthritis (JIA) at the outpatient clinic of Kagoshima University Hospital, we enrolled 25 who were controlled by treatment. All children were unimmunized and were vaccinated against HBV according to the schedule. Their responses to the vaccine and vaccine adverse events were examined during their visits.
  
  
  RESULTS
  Nineteen of the 25 patients with JIA controlled by treatment developed effective antibody responses (76%). All eight patients with JIA below 10 years of age achieved seroconversion. The seroconversion was not influenced by biologics. Five adverse events were observed (6.7%). The rate of all adverse events did not surpass that of a previous report, and all adverse events were immediately resolved. None of the patients with JIA experienced a flare-up or clinical deterioration related to the vaccination.
  
  
  CONCLUSIONS
  HBV vaccination is safe and effective. Pediatric rheumatologists should consider HBV vaccination for unimmunized patients with JIA, because the response to HBV vaccine might be influenced by age, and children have a higher risk for potential HBV infection than adults.
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .|b Education Center for Doctors on Remote Islands and in Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Japan , and.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Nerome
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .
authors.forename: Harumi
authors.initials: H
authors.lastname: Akaike
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nonaka
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .
authors.forename: Tomoko
authors.initials: T
authors.lastname: Takezaki
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kubota
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yamato
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamasaki
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Imanaka
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kawano
authors.affiliation: a Department of Pediatrics , Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan .|c Faculty of Medicine, School of Health Sciences, Kagoshima University , Kagoshima , Japan.
authors.forename: Syuji
authors.initials: S
authors.lastname: Takei
mesh_terms: D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000150:complications* / Q000188:drug therapy; D001685:Biological Factors / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000150:complications / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000494:pharmacology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D014611:Vaccination / Q000379:methods*; D055815:Young Adult
chemical_list: D001685:Biological Factors; D017325:Hepatitis B Vaccines
keywords: Biologics; Hepatitis B virus; Juvenile idiopathic arthritis; Vaccination