title: Localization of Radiolabeled Somatostatin Analogs in the Spleen.
abstract: Radiolabeled somatostatin (SST) analogs, used to visualize and treat SST receptor (SSTR)-expressing neuroendocrine tumors, also accumulate in the spleen. There is a high interpatient variation and no significant radiation-induced splenic toxicity; however, an absorbed dose-related reduction in spleen size was detected. However, the exact localization of radioactivity and the role of SST receptors in splenic retention are unknown. Therefore, we performed ex vivo micro-SPECT of the isolated spleen from a patient with a pancreatic neoplasm after 1 GBq (27 mCi) Lu-DOTATATE administration, followed by autoradiography and immunohistochemistry. Ex vivo autoradiography demonstrated convincingly that most radioactivity accumulated in red pulp.
authors.affiliation: From the *Department of Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands; †Department of General and Visceral Surgery, and ‡Theranostics Center for Molecular Radiotherapy and Molecular Imaging, Zentralklinik Bad Berka, Bad Berka; §Institute of Pharmacology and Toxicology, Jena University Hospital, Jena; ∥Laboratory of Pathology and Cytology, Zentralklinik Bad Berka, Bad Berka, Germany; and ¶Department of Radiology, Erasmus MC, Rotterdam, the Netherlands.
authors.forename: Marleen
authors.initials: M
authors.lastname: Melis
authors.forename: Daniel
authors.initials: D
authors.lastname: Kaemmerer
authors.forename: Jan
authors.initials: J
authors.lastname: de Swart
authors.forename: Harshad R
authors.initials: HR
authors.lastname: Kulkarni
authors.forename: Amelie
authors.initials: A
authors.lastname: Lupp
authors.forename: Jörg
authors.initials: J
authors.lastname: Sänger
authors.forename: Harald C
authors.initials: HC
authors.lastname: Groen
authors.forename: Mark W
authors.initials: MW
authors.lastname: Konijnenberg
authors.forename: Marion
authors.initials: M
authors.lastname: de Jong
authors.forename: Richard P
authors.initials: RP
authors.lastname: Baum
mesh_terms: D006801:Humans; D015282:Octreotide / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D009942:Organometallic Compounds / Q000009:adverse effects* / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000009:adverse effects* / Q000493:pharmacokinetics; D013154:Spleen / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C447941:lutetium Lu 177 dotatate; D015282:Octreotide