title: [Human papillomavirus E7 oncoprotein and its role in the cell transformation].
abstract: Human papillomavirus (HPV) genome codifies proteins with oncogenic activity, such as E7. Due to its structural characteristics, the E7 protein may interact with a great variety of cellular proteins. Some of these proteins act as cell-cycle regulators and other proteins function as transcription factors. These interactions play an important role in the induction of mitogenic pathways, in G1/S progression, and the inhibition of cellular differentiation, which increases chromosomal instability. The aim of this study is to describe the interactions of HPV E7 protein with different cellular proteins, and their contribution in the development of cervical cancer.
authors.affiliation: Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Metepec, Puebla, México. veronica_vallejo@yahoo.com.
authors.forename: Verónica
authors.initials: V
authors.lastname: Vallejo-Ruiz
authors.forename: Noé
authors.initials: N
authors.lastname: Velázquez-Márquez
authors.forename: Patricia
authors.initials: P
authors.lastname: Sánchez-Alonso
authors.forename: Gerardo
authors.initials: G
authors.lastname: Santos-López
authors.forename: Julio
authors.initials: J
authors.lastname: Reyes-Leyva
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000378:metabolism*; D050725:Papillomavirus E7 Proteins / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000821:virology*
chemical_list: D015415:Biomarkers; D050725:Papillomavirus E7 Proteins
keywords: Cervical cancer; Papillomavirus; Papillomavirus E7 proteins