title: Effect of a chlorhexidine-containing brush-on gel on peri-implant mucositis.
abstract: OBJECTIVE
  The aim was to evaluate the effect of a chlorhexidine-containing brush-on gel when used as supplement to oral hygiene instructions and mechanical debridement, on peri-implant mucositis in adults.
  
  
  METHODS
  The study group consisted of 38 adults (48-87 years.) with peri-implant mucositis that were consecutively enrolled in three private clinics after informed consent. The study employed a double-blind controlled design with two parallel arms. After baseline registrations, oral hygiene reinforcement and mechanical debridement, the patients were randomly allocated to either a test group with once daily tooth brushing with an oral care brush-on gel containing 0.2% chlorhexidine digluconate (Cervitec Gel) or a control gel group. The duration of the intervention was 12 weeks. The primary outcome was bleeding on probing (BOP) and secondary endpoints were local plaque score (LPS) and pocket probing depth (PPD).
  
  
  RESULTS
  The groups were balanced at baseline. The daily use of the chlorhexidine-containing gel resulted in reduced BOP after 4 and 12 weeks compared with the control group (P < 0.05). The PPD was significantly reduced (P < 0.05) after 12 weeks compared to baseline in the test group, but not in the control group. No side effects or adverse events were reported.
  
  
  CONCLUSIONS
  The present findings indicated moderate but significant improvements of clinical parameters when mechanical debridement was combined with a self-applied oral care brush-on gel for the management of peri-implant mucositis.
authors.affiliation: Faculty of Odontology, Department of Periodontology, Malmö University, Malmö, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Hallström
authors.affiliation: Maxillofacial unit, Halland Hospital, Halmstad, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Lindgren
authors.affiliation: Maxillofacial unit, Halland Hospital, Halmstad, Sweden.|Faculty of Health and Medical Sciences, Department of Odontology, Section for Cariology, Endodontics, Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Twetman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002710:Chlorhexidine / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003646:Debridement; D015921:Dental Implants; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene; D010512:Periodontal Index; D013280:Stomatitis / Q000188:drug therapy*; D013943:Thymol / Q000008:administration & dosage*; D014099:Toothbrushing
chemical_list: D015921:Dental Implants; D004338:Drug Combinations; D005782:Gels; C079161:chlorhexidine, thymol drug combination; D013943:Thymol; D002710:Chlorhexidine
keywords: antibacterials; dental plaque; gingival bleeding; periodontal pockets