title: Label-free biosensors based on in situ formed and functionalized microwires in microfluidic devices.
abstract: Label-free biosensors based on in situ formed and functionalized TTF-Au wires were developed using an integrated microfluidic system. By applying different modification protocols, TTF-Au wires were successfully used for sensitive label-free detection of catecholamines and human IgG by Raman spectroscopy.
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zürich, Switzerland. petra.dittrich@bsse.ethz.ch and SALSA graduate school, Humboldt-Universität zu Berlin, Germany.
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Laboratory for Nanometallurgy, Department of Materials, ETH Zürich, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Wyss
authors.affiliation: Leibniz-Institute for Analytical Sciences, ISAS Berlin, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Esser
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zürich, Switzerland. petra.dittrich@bsse.ethz.ch.
authors.forename: Petra S
authors.initials: PS
authors.lastname: Dittrich
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D002395:Catecholamines / Q000032:analysis; D005453:Fluorescence; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry; D057230:Limit of Detection; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D013059:Spectrum Analysis, Raman; D013194:Staining and Labeling
chemical_list: D002395:Catecholamines; D007136:Immunoglobulins