title: Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum.
abstract: Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson's disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from naïve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats.
authors.affiliation: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain. rfranco123@gmail.com.|Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain. rfranco123@gmail.com.
authors.forename: Rafael
authors.initials: R
authors.lastname: Franco
authors.affiliation: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.|Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain.
authors.forename: Verònica
authors.initials: V
authors.lastname: Casadó-Anguera
authors.affiliation: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.|Laboratory of Neuroanatomy and Experimental Neurology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Muñoz
authors.affiliation: School of Pharmacy and Biomedical Sciences, University of Central Lancashire, PR1 2HE, Preston, UK.|Institute of Physiology, Academy of Sciences, Videnska 1083, 14220, Prague, Czech Republic.
authors.forename: Milos
authors.initials: M
authors.lastname: Petrovic
authors.affiliation: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.|Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Navarro
authors.affiliation: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.|Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain.
authors.forename: Estefanía
authors.initials: E
authors.lastname: Moreno
authors.affiliation: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.|Laboratory of Neuroanatomy of Basal Ganglia, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, 31008, Pamplona, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Lanciego
authors.affiliation: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.|Laboratory of Neuroanatomy and Experimental Neurology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Labandeira-García
authors.affiliation: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.|Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Cortés
authors.affiliation: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.|Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain.
authors.forename: Vicent
authors.initials: V
authors.lastname: Casadó
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism; D007839:Functional Laterality / Q000187:drug effects; D008297:Male; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D050637:Receptors, Dopamine D3 / Q000819:agonists / Q000378:metabolism
chemical_list: D001552:Benzazepines; D017447:Receptors, Dopamine D1; D050637:Receptors, Dopamine D3; C534628:SCH 23390; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D004298:Dopamine
keywords: 6-hydroxydopamine; Basal ganglia; Cooperativity index; Dyskinesia; G-protein-coupled receptor dimer; Lateralization