title: Enhanced remyelination following lysolecithin-induced demyelination in mice under treatment with fingolimod (FTY720).
abstract: Multiple sclerosis (MS) is a chronic, progressive demyelinating disorder which affects the central nervous system (CNS) and is recognized as the major cause of nervous system disability in young adults. Enhancing myelin repair by stimulating endogenous progenitors is a main goal in efforts for MS treatment. Fingolimod (FTY720) which is administrated as an oral medicine for relapsing-remitting MS has direct effects on neural cells. In this study, we hypothesized if daily treatment with FTY720 enhances endogenous myelin repair in a model of local demyelination induced by lysolecithin (LPC). We examined the response of inflammatory cells as well as resident OPCs and evaluated the number of newly produced myelinating cells in animals which were under daily treatment with FTY720. FTY720 at doses 0.3 and 1mg/kg decreased the inflammation score at the site of LPC injection and decreased the extent of demyelination. FTY720 especially at the lower dose increased the number of remyelinated axons and newly produced myelinating cells. These data indicate that repetitive treatment with FTY720, behind an anti-inflammatory effect, exerts beneficial effects on the process of endogenous repair of demyelinating insults.
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Yazdi
authors.affiliation: Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Developmental Biology, University of Science and Culture, ACECR, Tehran, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Baharvand
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address: mjavan@modares.ac.ir.
authors.forename: M
authors.initials: M
authors.lastname: Javan
mesh_terms: D000818:Animals; D003337:Corpus Callosum / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000068876:Fingolimod Hydrochloride / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008244:Lysophosphatidylcholines; D008297:Male; D008810:Mice, Inbred C57BL; D009186:Myelin Sheath / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D058953:Neural Stem Cells / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009836:Oligodendroglia / Q000187:drug effects / Q000473:pathology / Q000502:physiology
chemical_list: D007166:Immunosuppressive Agents; D008244:Lysophosphatidylcholines; D018696:Neuroprotective Agents; D000068876:Fingolimod Hydrochloride
keywords: fingolimod (FTY720); lysolecithin; mouse; myelin repair; oligodendrocyte progenitors