title: Efficacy of radioembolization according to tumor morphology and portal vein thrombosis in intermediate-advanced hepatocellular carcinoma.
abstract: OBJECTIVE
  We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC).
  
  
  METHODS
  Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated.
  
  
  RESULTS
  Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS.
  
  
  CONCLUSIONS
  A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.
authors.affiliation: Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Golfieri
authors.affiliation: Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mosconi
authors.affiliation: Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Alberta
authors.initials: A
authors.lastname: Cappelli
authors.affiliation: Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Giampalma
authors.affiliation: Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Galaverni
authors.affiliation: Medical Physics Unit, Radiology Unit, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Pettinato
authors.affiliation: Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Renzulli
authors.affiliation: Radiation Oncology Unit, Radiology Unit, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Monari
authors.affiliation: Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Bruna
authors.initials: B
authors.lastname: Angelelli
authors.affiliation: Department of Medical & Surgical Sciences, University of Bologna, Bologna, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pini
authors.affiliation: Department of Medical & Surgical Sciences, University of Bologna, Bologna, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Terzi
authors.affiliation: Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Ascanio
authors.affiliation: Radiology Unit, Department of Diagnostic & Preventive Medicine, S Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Garzillo
authors.affiliation: Department of Medical & Surgical Sciences, University of Bologna, Bologna, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Piscaglia
authors.affiliation: Department of Medical & Surgical Sciences, University of Bologna, Bologna, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Bolondi
authors.affiliation: Department of Medical & Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Trevisani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011169:Portal Vein / Q000473:pathology; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden; D020246:Venous Thrombosis / Q000209:etiology / Q000473:pathology; D055815:Young Adult; D015021:Yttrium Radioisotopes / Q000008:administration & dosage
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes
keywords: 90Y-radioembolization; infiltrative hepatocellular carcinoma; intermediate–advanced hepatocellular carcinoma; portal vein tumor thrombosis