title: [FREE CONSUMPTION OF GLUCOSE SOLUTION BY RATS AS A CRITERION FOR EVALUATION ITS ABSORPTION IN THE SMALL INTESTINE (Experimental study and mathematical modeling)].
abstract: The aim of the work is to analyze the relationship between consumption of glucose solution by rats and its absorption, and to use this fact for assessment of the absorptive capacity of the small intestine in non anesthetized animals in vivo. Consumption of glucose solution (200 g/l) by fasted rats was recorded in the control, and after administration of phloridzin--inhibitor of glucose active transport- or 3 hours after the restriction stress. On the mathematical model we studied the relative role of factors that can influence the temporal dynamics of glucose consumption by rats. The rate of glucose consumption was observed being decreased in the presence of phloridzin (1 mM), and be increased after the stress. The results of modeling are consistent with the experimental data and show that the rate of consumption of glucose solutions considerably more depends on the transport activity of the small intestine than on glucose concentration in the solution, or on the substrate regulation of the stomach emptying. Analysis of dynamics of consumption of glucose solution by intact rats may be considered as one of promising approaches to assessing the absorptive capacity of the small intestine under natural conditions.
authors.forename: A A
authors.initials: AA
authors.lastname: Gruzdkov
authors.forename: L V
authors.initials: LV
authors.lastname: Gromova
authors.forename: Yu V
authors.initials: YV
authors.lastname: Dmitrieva
authors.forename: A S
authors.initials: AS
authors.lastname: Alekseeva
mesh_terms: D000818:Animals; D005947:Glucose / Q000493:pharmacokinetics / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008954:Models, Biological; D010695:Phlorhizin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013549:Sweetening Agents / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D013549:Sweetening Agents; D010695:Phlorhizin; D005947:Glucose