title: Policaprolactone/polyvinylpyrrolidone/siloxane hybrid materials: Synthesis and in vitro delivery of diclofenac and biocompatibility with periodontal ligament fibroblasts.
abstract: In this paper, we report the synthesis of polycaprolactone (PCL) based hybrid materials containing hydrophilic domains composed of N-vinylpyrrolidone (VP), and γ-methacryloxypropyltrimethoxysilane (MPS). The hybrid materials were obtained by RAFT copolymerization of N-vinylpyrrolidone and MPS using a pre-formed dixanthate-end-functionalized PCL as macro-chain transfer agent, followed by a post-reaction crosslinking step. The composition of the samples was determined by elemental and thermogravimetric analyses. Differential scanning calorimetry and X-ray diffraction indicated that the crystallinity of PCL decreases in the presence of the hydrophilic domains. Scanning electron microscopy images revealed that the samples present an interconnected porous structure on the swelling. Compared to PCL, the hybrid materials presented low water contact angle values and higher elastic modulus. These materials showed controlled release of diclofenac, and biocompatibility with human periodontal ligament fibroblasts.
authors.affiliation: Departamento de Química, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
authors.forename: José A
authors.initials: JA
authors.lastname: Peña
authors.affiliation: Centro de investigaciones Odontológicas, Facultad de Odontología, Pontificia Universidad Javeriana, Bogotá, Colombia. Electronic address: s.gutierrez@javeriana.edu.co.
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Gutiérrez
authors.affiliation: Centro de investigaciones Odontológicas, Facultad de Odontología, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Jean C
authors.initials: JC
authors.lastname: Villamil
authors.affiliation: Instituto de Química, Universidad de Antioquia, Medellin, Colombia.
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Agudelo
authors.affiliation: Grupo de Macromoléculas, Departamento de Química, Universidad Nacional de Colombia, Carrera 45 No 26-85, edificio 451 of. 449, Bogotá D.C. Colombia. Electronic address: ldperezp@unal.edu.co.
authors.forename: León D
authors.initials: LD
authors.lastname: Pérez
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004008:Diclofenac / Q000737:chemistry / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D010513:Periodontal Ligament / Q000166:cytology; D011091:Polyesters / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011091:Polyesters; D011760:Pyrrolidinones; D012833:Siloxanes; D004008:Diclofenac; C016240:polycaprolactone; C042670:N-vinyl-2-pyrrolidinone
keywords: Human periodontal ligament fibroblasts; Hybrid material; Polycaprolactone; Polyvinylpyrrolidone