title: Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel.
abstract: OBJECTIVE
  To investigate the efficacy of a 10% gel of unripe banana (Musa sapientum) peel in treating surgical wounds in rats.
  
  
  METHODS
  A longitudinal, prospective, randomized triple-blind study was conducted with 60 Wistar rats (Rattus norvegicus albinus) weighing approximately 400g. The animals were randomly divided into: control group (treated with gel containing no active ingredient) and study group (treated with 10% gel of unripe banana peel). The gel was applied every three days to a 4x4-cm surgical wound created on the back of each animal (day 0) in both groups. Tissue samples were collected for histological analysis on days 14, 21 and 28.
  
  
  RESULTS
  On day 14, more extensive vascular proliferation (p=0.023), presence of mononuclear cells (p=0.000), fibroblast proliferation (p=0.012), re-epithelialization (p=0.000), and decreased presence of polymorphonuclear cells (p=0.010) were observed in the study group than in controls. No significant between-group difference in the presence of polymorphonuclear cells was found on day 21. Fibroblast proliferation was significantly greater (p=0.006) in the study group than in the control group on day 28.
  
  
  CONCLUSIONS
  The 10% gel of unripe banana peel showed anti-inflammatory activity and stimulated wound healing in rat skin when compared with a gel containing no active ingredient.
authors.affiliation: School of Medical Sciences, Universidade do Vale do Sapucaí, Pouso Alegre, MG, BR.
authors.forename: Dênia Amélia Novato Castelli
authors.initials: DA
authors.lastname: Von Atzingen
authors.affiliation: School of Medical Sciences, UNIVÁS, Pouso Alegre, MG, BR.
authors.forename: Adriana Rodrigues dos Anjos
authors.initials: AR
authors.lastname: Mendonça
authors.affiliation: School of Medical Sciences, UNIVÁS, Pouso Alegre, MG, BR.
authors.forename: Marcos
authors.initials: M
authors.lastname: Mesquita Filho
authors.affiliation: School of Medicine, UNIVÁS, BR.
authors.forename: Vinícius Alves
authors.initials: VA
authors.lastname: Alvarenga
authors.affiliation: School of Medicine, UNIVÁS, BR.
authors.forename: Vinícius Almeida
authors.initials: VA
authors.lastname: Assis
authors.affiliation: School of Medicine, UNIVÁS, BR.
authors.forename: Afonso Esteves
authors.initials: AE
authors.lastname: Penazzo
authors.affiliation: School of Medicine, UNIVÁS, BR.
authors.forename: Julio Henrique
authors.initials: JH
authors.lastname: Muzetti
authors.affiliation: School of Medicine, UNIVÁS, BR.
authors.forename: Thaisa Sousa
authors.initials: TS
authors.lastname: Rezende
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D005782:Gels / Q000008:administration & dosage; D008297:Male; D028521:Musa / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000008:administration & dosage*; D011446:Prospective Studies; D011897:Random Allocation; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D005782:Gels; D010936:Plant Extracts