title: The role of cathepsin K in oral and maxillofacial disorders.
abstract: Cathepsin K (CTSK) was thought to be a collagenase, specifically expressed by osteoclasts, and played an important role in bone resorption. However, more and more research found that CTSK was expressed in more extensive cells, tissues, and organs. It may not only participate in regulating human physiological activity, but also be closely related to a variety of disease. In this review, we highlight the relationship between CTSK and oral and maxillofacial disorders on the following three aspects: oral and maxillofacial abnormities in patients with pycnodysostosis caused by CTSK mutations, oral and maxillofacial abnormities in Ctsk(-/-) mice, and the role of CTSK in oral and maxillofacial diseases, including periodontitis, peri-implantitis, tooth movement, oral and maxillofacial tumor, root resorption, and periapical disease.
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: X
authors.initials: X
authors.lastname: Wen
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: L-z
authors.initials: LZ
authors.lastname: Yi
authors.affiliation: Department of Stomatology, Northwest Women's and Children's Hospital, Xi'an, China.
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: J-h
authors.initials: JH
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.|Clinic of Oral Rare and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xue
mesh_terms: D000818:Animals; D056657:Cathepsin K / Q000235:genetics* / Q000378:metabolism*; D019465:Craniofacial Abnormalities / Q000150:complications / Q000235:genetics*; D006801:Humans; D051379:Mice; D009056:Mouth Abnormalities / Q000235:genetics; D009059:Mouth Diseases / Q000235:genetics* / Q000378:metabolism; D058631:Pycnodysostosis / Q000150:complications / Q000235:genetics*
chemical_list: D056657:Cathepsin K
keywords: cathepsin K; periapical diseases; periodontitis; pycnodysostosis; root resorption; tooth movement