title: Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.
abstract: It has been suggested that hexokinase 1 (HK1) is involved in tumorigenesis. However, the expression dynamics of HK1 and its prognostic significance in human colorectal cancer (CRC) still remain unclear. The aim of the present study was to investigate the expression of HK1 and its prognostic significance in CRC. In this study, immunohistochemical analysis was used to examine the expression dynamics of HK1 in CRC tissues from two independent cohorts. Receiver operating characteristic curve analysis, Kaplan-Meier curves, and Cox regression analysis were utilized to investigate the prognostic significance. Results showed that a high expression of HK1 was observed in 106 of 393 (27.0 %) and 69 of 229 (30.1 %) of CRC in the training cohort and validation cohort, respectively. Further correlation analyses indicated that the increased HK1 expression was strongly correlated with the pN classification and TNM stage. Both cohorts showed a close association between the overexpression of HK1 and poorer overall survival. Importantly, multivariate analysis identified HK1 expression in CRC as an independent prognostic factor. Overexpression of HK1 may act as a significant biomarker of poor prognosis for patients with CRC.
authors.affiliation: Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou, 510655, China.|Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangdong, Guangzhou, 510655, China.
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou, 510655, China.|Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangdong, Guangzhou, 510655, China.
authors.forename: Xutao
authors.initials: X
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangdong, Guangzhou, 510060, China.|Department of Pathology, Sun Yat-sen University Cancer Center, Guangdong, Guangzhou, 510060, China.
authors.forename: Muyan
authors.initials: M
authors.lastname: Cai
authors.affiliation: Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou, 510655, China.|Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangdong, Guangzhou, 510655, China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou, 510655, China.|Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangdong, Guangzhou, 510655, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Lian
authors.affiliation: Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou, 510655, China.|Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangdong, Guangzhou, 510655, China.
authors.forename: Dejun
authors.initials: D
authors.lastname: Fan
authors.affiliation: Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou, 510655, China.|Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangdong, Guangzhou, 510655, China.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou, 510655, China.|Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangdong, Guangzhou, 510655, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Lan
authors.affiliation: Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou, 510655, China. zs6ywjp@163.com.|Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangdong, Guangzhou, 510655, China. zs6ywjp@163.com.
authors.forename: Jianping
authors.initials: J
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D005260:Female; D006593:Hexokinase / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry / Q000706:statistics & numerical data; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C472074:HK1 protein, human; D006593:Hexokinase
keywords: Biomarker; Colorectal cancer; Hexokinase; Prognosis