title: CT-based renal volume measurements: correlation with renal function in patients with renal tumours.
abstract: OBJECTIVE
  To evaluate the correlations between renal cortical volume (RCV), renal parenchymal volume (RPV), and renal function in patients with renal tumours before and after laparoscopic partial nephrectomy (LPN).
  
  
  METHODS
  Thirty-five patients with a single unilateral renal tumour who had undergone contrast-enhanced computed tomography (CT) and renal nuclear scintigraphy before and after LPN were retrospectively studied. RCV and RPV were calculated as renal volume, excluding tumours or cysts, using a semi-automatic segmentation program. The correlations between RCV, RPV, and glomerular filtration rate (GFR) were undertaken preoperatively and postoperatively using the Pearson correlation coefficient.
  
  
  RESULTS
  Preoperatively, the correlations between RCV and GFR, and RPV and GFR for the operated kidneys was r=0.502 (p=0.002) and 0.527 (p=0.001), respectively, whereas the correlations for the contralateral side were r=0.384 (p=0.023) and r=0.412 (p=0.014). The mean RCV and RPV of the operated kidneys decreased by 27.4% and 24.8%. The mean split GFR of the operated kidneys decreased by 36.4%. Postoperatively, residual RCV (r=0.619, p<0.001) and RPV (r=0.593, p<0.001) correlated moderately with the GFR of the operated kidneys.
  
  
  CONCLUSIONS
  Renal volume, both RCV and RPV, had a moderate relationship with renal function before and after operation. CT-based renal volume measurements could serve as a simple and effective method for estimation of postoperative renal function.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Lab of Image Science and Technology, School of Computer Science and Engineering, Southeast University, 2 Sipailou, Nanjing, 210096, Jiangsu, China.
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. Electronic address: aleenxu@163.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. Electronic address: Lijun.tang@hotmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed