title: [Infiltrated T Cells Induce the Accumulation of Myeloid-derived Suppressor Cells in Tumor Microenvironment].
abstract: OBJECTIVE
  To determine the role of infiltrated T cells in the accumulation of myeloid-derived suppressor cells (MDSCs) in tumor microenvironment.
  
  
  METHODS
  T-cell-deficient nude mice models were established using BALB/c mice. Growth of tumors was compared between those with and without adoptive transfer of T cells. Pathological changes of the tumors were examined with HE histological analysis. The levels of MDSCs were detected with flow cytometry (FACS).
  
  
  RESULTS
  Tumor growth was promoted in T-cell-deficient nude mice, which was accompanied with lower levels of MDSCs compared with BALB/c mice (P < 0.05). T cell transfer increased the level of MDSCs significantly (P < 0.05). T cells depletion decreased the level of MDSCs (P < 0.05).
  
  
  CONCLUSIONS
  Infiltrated T cells induce the accumulation of MDSCs in tumor microenvironment, and influence tumor growth.
authors.forename: Xiao-yun
authors.initials: XY
authors.lastname: Liu
authors.forename: Yan-tong
authors.initials: YT
authors.lastname: Liu
authors.forename: Ye
authors.initials: Y
authors.lastname: Mao
authors.forename: Jing
authors.initials: J
authors.lastname: Du
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.forename: Jia-yun
authors.initials: JY
authors.lastname: Yu
authors.forename: Min
authors.initials: M
authors.lastname: Luo
authors.forename: Ya-xiong
authors.initials: YX
authors.lastname: Sang
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Guang-chao
authors.initials: GC
authors.lastname: Xu
authors.forename: Xiao-xiao
authors.initials: XX
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Shao
authors.forename: Yu-quan
authors.initials: YQ
authors.lastname: Wei
mesh_terms: D000818:Animals; D005434:Flow Cytometry; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D022423:Myeloid Cells / Q000166:cytology*; D009369:Neoplasms / Q000473:pathology*; D013601:T-Lymphocytes / Q000166:cytology*; D059016:Tumor Microenvironment