title: The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands.
abstract: The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options.
authors.affiliation: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Southan
authors.affiliation: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.
authors.forename: Joanna L
authors.initials: JL
authors.lastname: Sharman
authors.affiliation: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.
authors.forename: Helen E
authors.initials: HE
authors.lastname: Benson
authors.affiliation: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.
authors.forename: Elena
authors.initials: E
authors.lastname: Faccenda
authors.affiliation: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Pawson
authors.affiliation: School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
authors.forename: Stephen P H
authors.initials: SP
authors.lastname: Alexander
authors.affiliation: Laboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Edinburgh, EH8 9LE, UK.
authors.forename: O Peter
authors.initials: OP
authors.lastname: Buneman
authors.affiliation: Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Davenport
authors.affiliation: School of Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
authors.forename: John C
authors.initials: JC
authors.lastname: McGrath
authors.affiliation: Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
authors.forename: John A
authors.initials: JA
authors.lastname: Peters
authors.affiliation: Spedding Research Solutions SARL, Le Vésinet 78110, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Spedding
authors.affiliation: Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Catterall
authors.affiliation: PIQUR Therapeutics, Basel 4057, Switzerland.
authors.forename: Doriano
authors.initials: D
authors.lastname: Fabbro
authors.affiliation: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK jamie.davies@ed.ac.uk.
authors.forename: Jamie A
authors.initials: JA
authors.lastname: Davies
mesh_terms: D064229:Biological Ontologies; D062313:Databases, Pharmaceutical; D004194:Disease; D055808:Drug Discovery; D015894:Genome, Human; D006801:Humans; D020407:Internet; D008024:Ligands; D010330:Patents as Topic; D010770:Phosphotransferases / Q000037:antagonists & inhibitors; D011506:Proteins / Q000187:drug effects* / Q000235:genetics
chemical_list: D008024:Ligands; D011506:Proteins; D010770:Phosphotransferases