title: Successful Management of a Chronic Refractory Leg Ulcer in an Adolescent with Sickle Cell Anemia.
abstract: Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by a wide range of clinical manifestations. Chronic leg ulcers are a disabling complication with repercussions on the quality of life. We report the case of a 14-year-old girl with a diagnosis of SCD who developed a chronic leg ulcer that was successfully treated with a multi-disciplinary approach, including local and systemic therapies. The role of different treatments, in particular low molecular weight heparin, in the refractory chronic leg ulcer healing process will be discussed.
authors.affiliation: Giovanni Paolino, MD, Clinica Dermatologica, La Sapienza University of Rome, Viale del Policlinico 15, 00186 Rome, Italy; gio8519@libero.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Paolino
authors.forename: Michelina
authors.initials: M
authors.lastname: Santopietro
authors.forename: Giovanna
authors.initials: G
authors.lastname: Palumbo
authors.forename: Maria Giuseppina
authors.initials: MG
authors.lastname: Onesti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Micozzi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Venosi
authors.forename: Marica
authors.initials: M
authors.lastname: Laurino
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Ferrazza
authors.forename: Pasquale
authors.initials: P
authors.lastname: Fino
authors.forename: Robin
authors.initials: R
authors.lastname: Foà
authors.forename: Fiorina
authors.initials: F
authors.lastname: Giona
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology* / Q000628:therapy*