title: Primary Immunodeficiency Masquerading as Allergic Disease.
abstract: Primary immune deficiencies (PIDs) are an uncommon heterogeneous group of diseases that result from fundamental defects in the proteins and cells that enable specific immune responses. Common allergic reactions (eczema, allergic rhinitis, asthma, and food allergies) are exaggerated immune responses that may be manifestations of an underlying PID. Early diagnosis and treatment has significant bearing on outcome. Immune suppression with systemic corticosteroids in these immune compromised individuals can lead to life threatening dissemination of infections.
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA. Electronic address: chans@njhealth.org.
authors.forename: Sanny K
authors.initials: SK
authors.lastname: Chan
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.
authors.forename: Erwin W
authors.initials: EW
authors.lastname: Gelfand
mesh_terms: D003937:Diagnosis, Differential; D019468:Disease Management; D004485:Eczema / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn
chemical_list: D007073:Immunoglobulin E
keywords: Allergic disease; Corticosteroids; Eczema; Elevated IgE; Primary immune deficiency