title: Peripheral adaptive filtering in human olfaction? Three studies on prevalence and effects of olfactory training in specific anosmia in more than 1600 participants.
abstract: Selective processing of environmental stimuli improves processing capacity and allows adaptive modulation of behavior. The thalamus provides an effective filter of central sensory information processing. As olfactory projections, however, largely bypass the thalamus, other filter mechanisms must consequently have evolved for the sense of smell. We investigated whether specific anosmia - the inability to perceive a specific odor whereas detection of other substances is unaffected - represents an effective peripheral filter of olfactory information processing. In contrast to previous studies, we showed in a sample of 1600 normosmic subjects, that specific anosmia is by no means a rare phenomenon. Instead, while the affected odor is highly individual, the general probability of occurrence of specific anosmia is close to 1. In addition, 25 subjects performed daily olfactory training sessions with enhanced exposure to their particular "missing" smells for the duration of three months. This resulted in a significant improvement of sensitivity towards the respective specific odors. We propose specific anosmia to occur as a rule, rather than an exception, in the sense of smell. The lack of perception of certain odors may constitute a flexible peripheral filter mechanism, which can be altered by exposure.
authors.affiliation: Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Dresden, Germany; TU Dresden, Department of Psychotherapy and Psychosomatic Medicine, Dresden, Germany.
authors.forename: Ilona
authors.initials: I
authors.lastname: Croy
authors.affiliation: Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Dresden, Germany.
authors.forename: Selda
authors.initials: S
authors.lastname: Olgun
authors.affiliation: Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Dresden, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Mueller
authors.affiliation: Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Dresden, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Schmidt
authors.affiliation: Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Dresden, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Muench
authors.affiliation: Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Dresden, Germany.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Hummel
authors.affiliation: Department of Cell Physiology, Ruhr University Bochum, Bochum, Germany.
authors.forename: Guenter
authors.initials: G
authors.lastname: Gisselmann
authors.affiliation: Department of Cell Physiology, Ruhr University Bochum, Bochum, Germany.
authors.forename: Hanns
authors.initials: H
authors.lastname: Hatt
authors.affiliation: Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Dresden, Germany. Electronic address: thummel@mail.zih.tu-dresden.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hummel
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009812:Odorants / Q000517:prevention & control*; D000857:Olfaction Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012677:Sensation / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology*; D012903:Smell / Q000502:physiology*; D055815:Young Adult
keywords: Attention; Filter; Odor; Olfaction; Perception; Periphery