title: Construction of a sensitive and selective sensor for morphine using chitosan coated Fe3O4 magnetic nanoparticle as a modifier.
abstract: A simple and sensitive sensor based on carbon paste electrode (CPE) modified by chitosan-coated magnetic nanoparticle (CMNP) was developed for the electrochemical determination of morphine (MO). The proposed sensor was characterized with scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The electrooxidation of MO was studied on modified carbon paste electrode using cyclic voltammetry, chronoamperometry and differential pulse voltammetry as diagnostic techniques. The oxidation peak potential of morphine on the CMNP/CPE appeared at 380 mV which was accompanied with smaller overpotential and increase in oxidation peak current compared to that obtained on the bare carbon paste electrode (CPE). Under optimum conditions the sensor provides two linear DPV responses in the range of 10-2000 nM and 2-720 μM for MO with a detection limit of 3 nM. The proposed sensor was successfully applied for monitoring of MO in serum and urine samples and satisfactory results were obtained.
authors.affiliation: Department of Chemistry, Behbahan Khatam Al-Anbia University of Technology, Behbahan, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Dehdashtian
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran. Electronic address: mbgholivand@yahoo.com.
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Gholivand
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Shamsipur
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
authors.forename: Samira
authors.initials: S
authors.lastname: Kariminia
mesh_terms: D002244:Carbon; D048271:Chitosan / Q000737:chemistry*; D058266:Dielectric Spectroscopy / Q000379:methods*; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D009020:Morphine / Q000032:analysis*; D013499:Surface Properties
chemical_list: D058185:Magnetite Nanoparticles; D002244:Carbon; D009020:Morphine; D048271:Chitosan
keywords: Chitosan-coated magnetic nanoparticle; Chronoamperometry; Cyclic voltammetry; Differential pulse voltammetry; Electrochemical impedance spectroscopy; Modified carbon paste electrode; Morphine