title: Dietary Mannoheptulose Increases Fasting Serum Glucagon Like Peptide-1 and Post-Prandial Serum Ghrelin Concentrations in Adult Beagle Dogs.
abstract: There is a growing interest in the use of nutraceuticals for weight management in companion animals. The purpose of this study was to determine the effects of mannoheptulose (MH), a sugar in avocados that inhibits glycolysis, on energy metabolism in adult Beagle dogs. The study was a double-blind, randomized controlled trial where dogs were allocated to a control (CON, n = 10, 10.1 ± 0.4 kg) or MH containing diet (168 mg/kg, n = 10, 10.3 ± 0.4 kg). Blood was collected after an overnight fast and 1 h post-feeding (week 12) to determine serum satiety related hormones and biochemistry. Resting and post-prandial energy expenditure and respiratory quotient were determined by indirect calorimetry (weeks 4 and 8). Physical activity was measured using an accelerometer (weeks 3, 7, 11). Body composition was assessed using dual X-ray absorptiometry (week 12). MH significantly (p < 0.05) increased fasting serum glucagon-like peptide-1 and post-prandial serum ghrelin. MH tended (p < 0.1) to increase fasting serum gastric inhibitory peptide and decrease physical activity. Together, these findings suggest that dietary MH has the ability to promote satiation and lowers daily energy expenditure.
authors.affiliation: Centre for Nutrition Modelling, Department of Animal and Poultry Science, University of Guelph, Guelph, ON N1G 2W1, Canada. lmcknigh@uoguelph.ca.
authors.forename: Leslie L
authors.initials: LL
authors.lastname: McKnight
authors.affiliation: The Iams Company, 6571 State Route 503 North, Lewisburg, OH 45338, USA. ryan.eyre@effem.com.
authors.forename: Ryan
authors.initials: R
authors.lastname: Eyre
authors.affiliation: The Iams Company, 6571 State Route 503 North, Lewisburg, OH 45338, USA. margaret.gooding@effem.com.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Gooding
authors.affiliation: The Iams Company, 6571 State Route 503 North, Lewisburg, OH 45338, USA. gary.m.davenport@gmail.com.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Davenport
authors.affiliation: Centre for Nutrition Modelling, Department of Animal and Poultry Science, University of Guelph, Guelph, ON N1G 2W1, Canada. kate.shoveller@effem.com.|The Iams Company, 6571 State Route 503 North, Lewisburg, OH 45338, USA. kate.shoveller@effem.com.
authors.forename: Anna Kate
authors.initials: AK
authors.lastname: Shoveller
keywords: Beagle; body composition; dietary strategies; energy metabolism; ghrelin; glucagon-like peptide-1; indirect calorimetry; mannoheptulose; physical activity; satiety