title: GdDOTAGA(C18)2: an efficient amphiphilic Gd(iii) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes.
abstract: A new amphiphilic GdDOTA-like complex functionalized with two octadecyl chains was synthesised and incorporated into the bilayer of liposomes and dendrimersomes. (1)H NMR relaxometric studies and in vivo MRI experiments on mice bearing a syngeneic melanoma tumour have shown a great improvement in performance.
authors.affiliation: Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Centro di Imaging Molecolare e Preclinico, Università degli Studi di Torino, Via Nizza 52, Torino, 10126, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Filippi
authors.affiliation: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, Alessandria, 15121, Italy. lorenzo.tei@uniupo.it.
authors.forename: D
authors.initials: D
authors.lastname: Remotti
authors.affiliation: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, Alessandria, 15121, Italy. lorenzo.tei@uniupo.it.
authors.forename: M
authors.initials: M
authors.lastname: Botta
authors.affiliation: Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Centro di Imaging Molecolare e Preclinico, Università degli Studi di Torino, Via Nizza 52, Torino, 10126, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Terreno
authors.affiliation: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, Alessandria, 15121, Italy. lorenzo.tei@uniupo.it.
authors.forename: L
authors.initials: L
authors.lastname: Tei
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000737:chemistry*; D005260:Female; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D000068936:Theranostic Nanomedicine; D014018:Tissue Distribution
chemical_list: D050091:Dendrimers; D008081:Liposomes; D009942:Organometallic Compounds; D005682:Gadolinium