title: Association of Metabolic Syndrome with Serum Adipokines in Community-Living Elderly Japanese Women: Independent Association with Plasminogen Activator-Inhibitor-1.
abstract: BACKGROUND
  Associations between metabolic syndrome (MetS) with serum adipokines and basal lipoprotein lipase mass (serum LPL) have not been extensively studied in elderly Asians, who in general have lower body mass index than European populations.
  
  
  METHODS
  A cross-sectional analysis was conducted including 159 community-living elderly Japanese women whose age averaged 77 years. MetS was defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria, but using a body mass index ≥25 kg/m(2) instead of waist circumference. Serum LPL, leptin, adiponectin, plasminogen activator inhibitor 1 (PAI-1), interleukin-6, tumor necrosis factor-alpha, and high-sensitivity C-reactive protein were measured.
  
  
  RESULTS
  Both the presence of MetS and the number of MetS components were associated with higher homeostasis assessment of insulin resistance, serum levels of leptin, PAI-1, and tumor necrosis factor-alpha and with lower serum levels of LPL and adiponectin (all P < 0.05), but not with high-sensitivity C-reactive protein and interleukin-6. Among six biomarkers of MetS, PAI-1 remained associated with MetS independent of fat mass index and insulin resistance.
  
  
  CONCLUSIONS
  Although proinflammatory, prothrombotic, and anti-inflammatory states were associated with MetS, higher PAI-1 was associated with MetS independent of fat mass index and insulin resistance in elderly Japanese women, in whom obesity is rare.
authors.affiliation: 1 Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University , Nishinomiya, Hyogo, Japan .
authors.forename: Mika
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: 2 Postgraduate School of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University , Nishinomiya, Hyogo, Japan .
authors.forename: Ayaka
authors.initials: A
authors.lastname: Tsuboi
authors.affiliation: 1 Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University , Nishinomiya, Hyogo, Japan .|3 Research Institutes for Nutrition Sciences, School of Human Environmental Sciences, Mukogawa Women's University , Nishinomiya, Hyogo, Japan .
authors.forename: Miki
authors.initials: M
authors.lastname: Kurata
authors.affiliation: 1 Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University , Nishinomiya, Hyogo, Japan .|2 Postgraduate School of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University , Nishinomiya, Hyogo, Japan .|3 Research Institutes for Nutrition Sciences, School of Human Environmental Sciences, Mukogawa Women's University , Nishinomiya, Hyogo, Japan .
authors.forename: Keisuke
authors.initials: K
authors.lastname: Fukuo
authors.affiliation: 2 Postgraduate School of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University , Nishinomiya, Hyogo, Japan .|4 Diabetes Division, Sadamitsu Hospital , Kakogawa, Hyogo, Japan .
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kazumi
mesh_terms: D054392:Adipokines / Q000097:blood*; D050154:Adiposity; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000208:ethnology; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D057187:Independent Living; D018836:Inflammation Mediators / Q000097:blood; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D054392:Adipokines; D015415:Biomarkers; D018836:Inflammation Mediators; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human