title: Lactational exposure of mice to low levels of non-dioxin-like polychlorinated biphenyls increases susceptibility to neuronal stress at a mature age.
abstract: Lactational exposure to low levels of the sum of the six indicator polychlorinated biphenyls (Σ6 NDL-PCBs, 10ng/kg/day) is known to lead to persistent anxious behavior in young and adult offspring mice at postnatal days 40 and 160, respectively. At more advanced life stages, we evaluated the effects on the mouse brain of neuronal stress induced by the synaptotoxic amyloid-beta (Aβ) peptide. Perinatal exposure of lactating mice to Σ6 NDL-PCBs did not affect short-term memory performances of their offspring male mice aged 14 months as compared to control PCB-naive mice. However, following intracerebroventricular injection of soluble Aβ oligomers, significant impairments in long-term memory were detected in the mice that had been lactationally treated with Σ6 NDL-PCBs. In addition, immunoblot analyses of the synaptosomal fraction of hippocampal tissues from treated mice revealed a lower expression of the synaptic proteins synaptophysin and PSD-95. Though preliminary, our findings suggest for the first time that early exposure to low levels of NDL-PCBs induce late neuronal vulnerability to amyloid stress. Additional experiments are needed to confirm whether early environmental influences are involved in the etiology of brain aging and cognitive decline.
authors.affiliation: Neurotoxicologie Alimentaire et Bioactivité, MRCA, BP 4102, 57040 Metz, France; Université de Lorraine, Unité de Recherche Animal et Fonctionnalités des Produits Animaux (UR AFPA), EA3998, INRA USC 0340, France. Electronic address: arpine.el-nar@univ-lorraine.fr.
authors.forename: Arpiné Ardzivian
authors.initials: AA
authors.lastname: Elnar
authors.affiliation: Biodisponibilité et Fonctionnalités des Lipides Alimentaires, BFLA, ENSAIA, Avenue de la forêt de Haye, 54500 Vandœuvre-lès-Nancy, France; Université de Lorraine, Unité de Recherche Animal et Fonctionnalités des Produits Animaux (UR AFPA), EA3998, INRA USC 0340, France.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Allouche
authors.affiliation: Neurotoxicologie Alimentaire et Bioactivité, MRCA, BP 4102, 57040 Metz, France; Université de Lorraine, Unité de Recherche Animal et Fonctionnalités des Produits Animaux (UR AFPA), EA3998, INRA USC 0340, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Desor
authors.affiliation: Biodisponibilité et Fonctionnalités des Lipides Alimentaires, BFLA, ENSAIA, Avenue de la forêt de Haye, 54500 Vandœuvre-lès-Nancy, France; Université de Lorraine, Unité de Recherche Animal et Fonctionnalités des Produits Animaux (UR AFPA), EA3998, INRA USC 0340, France.
authors.forename: Frances T
authors.initials: FT
authors.lastname: Yen
authors.affiliation: Neurotoxicologie Alimentaire et Bioactivité, MRCA, BP 4102, 57040 Metz, France; Université de Lorraine, Unité de Recherche Animal et Fonctionnalités des Produits Animaux (UR AFPA), EA3998, INRA USC 0340, France.
authors.forename: Rachid
authors.initials: R
authors.lastname: Soulimani
authors.affiliation: Biodisponibilité et Fonctionnalités des Lipides Alimentaires, BFLA, ENSAIA, Avenue de la forêt de Haye, 54500 Vandœuvre-lès-Nancy, France; Université de Lorraine, Unité de Recherche Animal et Fonctionnalités des Produits Animaux (UR AFPA), EA3998, INRA USC 0340, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Oster
mesh_terms: D000375:Aging; D016229:Amyloid beta-Peptides / Q000008:administration & dosage; D000818:Animals; D003072:Cognition Disorders / Q000209:etiology; D004198:Disease Susceptibility; D000076122:Disks Large Homolog 4 Protein; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D051528:Guanylate Kinases / Q000378:metabolism; D007276:Injections, Intraventricular; D007774:Lactation / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008565:Membrane Proteins / Q000378:metabolism; D008570:Memory, Short-Term / Q000187:drug effects; D051379:Mice; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000503:physiopathology*
chemical_list: D016229:Amyloid beta-Peptides; D000076122:Disks Large Homolog 4 Protein; C501447:Dlg4 protein, mouse; D004785:Environmental Pollutants; D008565:Membrane Proteins; D011078:Polychlorinated Biphenyls; D051528:Guanylate Kinases
keywords: Aβ peptide; Brain aging; Developmental exposure; Learning and memory; Long-term effects; Σ6 NDL-PCBs