title: Dynamic Input Conductances Shape Neuronal Spiking
abstract: Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness, and homeostasis of neuronal signalling. The paper proposes that this question can be addressed through the analysis of dynamic input conductances. Those voltage-dependent curves aggregate the concomitant activity of all ion channels in distinct timescales. They are shown to shape the current-voltage dynamical relationships that determine neuronal spiking. We propose an experimental protocol to measure dynamic input conductances in neurons. In addition, we provide a computational method to extract dynamic input conductances from arbitrary conductance-based models and to analyze their sensitivity to arbitrary parameters. We illustrate the relevance of the proposed approach for modulation, compensation, and robustness studies in a published neuron model based on data of the stomatogastric ganglion of the crab Cancer borealis.
authors.affiliation: Systems and Modeling, Department of Electrical Engineering and Computer Science, University of Liège , Liège, B-4000, Belgium ; Laboratory of Pharmacology and GIGA Neurosciences, University of Liège , Liège, B-4000, Belgium ; Volen Center and Biology Department, Brandeis University , Waltham, Massachussetts 02454.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Drion
authors.affiliation: Systems and Modeling, Department of Electrical Engineering and Computer Science, University of Liège , Liège, B-4000, Belgium ; Department of Engineering, University of Cambridge , Cambridge, CB2 1PZ, United Kingdom.
authors.forename: Alessio
authors.initials: A
authors.lastname: Franci
authors.affiliation: Systems and Modeling, Department of Electrical Engineering and Computer Science, University of Liège , Liège, B-4000, Belgium ; Department of Mechanical and Aerospace Engineering, Princeton University , Princeton, New Jersey 08544.
authors.forename: Julie
authors.initials: J
authors.lastname: Dethier
authors.affiliation: Systems and Modeling, Department of Electrical Engineering and Computer Science, University of Liège , Liège, B-4000, Belgium ; Department of Engineering, University of Cambridge , Cambridge, CB2 1PZ, United Kingdom.
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Sepulchre
keywords: compensation; firing pattern; ion channels; neuromodulation