title: In vitro hemocompatibility of PVA-alginate ester as a candidate for hemodialysis membrane.
abstract: Alginate based biopolymer with improved physical and chemical properties after esterification using polyvinyl alcohol (PVA) has been studied for possible application as a hemodialysis membrane. The alginic acid to vinyl alcohol molar ratio was predetermined at 0, 0.1, 0.5 and 1. Mechanical strength, hydrophilicity and Ca(2+) adsorption of the membrane before and after modification were evaluated. The obtained PVA-alginate (PVA-Alg) ester membrane was also confirmed using FTIR and SEM. It shows that the PVA-Alg membrane tensile strength is higher than that of native alginate. The water contact angle of the membrane was found to be around 33-50°. The Ca(2+) adsorption capacity tends to decrease with the increase in molar ratio. Furthermore, the modified PVA-Alg ester membrane achieves better protein adsorption and platelet adhesion than the unmodified one. It also exhibits a dialysis performance of 47.1-50.0% for clearance of urea and 42.2-44.6% for clearance of creatinine, respectively. It is expected that this PVA-Alg ester may challenge cellulose acetate for potential application as hemodialysis membranes.
authors.affiliation: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia. Electronic address: chamri@hotmail.com.
authors.forename: Choirul
authors.initials: C
authors.lastname: Amri
authors.affiliation: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
authors.forename: Mudasir
authors.initials: M
authors.lastname: Mudasir
authors.affiliation: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
authors.forename: Dwi
authors.initials: D
authors.lastname: Siswanta
authors.affiliation: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
authors.forename: Roto
authors.initials: R
authors.lastname: Roto
mesh_terms: D000327:Adsorption; D000464:Alginates / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D001798:Blood Proteins / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D003404:Creatinine / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008567:Membranes, Artificial; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D006435:Renal Dialysis; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D014508:Urea / Q000737:chemistry
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D001798:Blood Proteins; D006603:Hexuronic Acids; D008567:Membranes, Artificial; D020723:Glucuronic Acid; D014508:Urea; D011142:Polyvinyl Alcohol; D003404:Creatinine; D002118:Calcium
keywords: Hemodialysis membrane; In vitro hemocompatibility; PVA-alginate ester