title: Variant Philadelphia translocations in chronic myeloid leukemia: A report of five cases.
abstract: The t (9;22)(q34;q11) translocation is found in about 90% of the chronic myeloid leukemia patients. About 5-10% of these patients have complex variant translocations involving a third chromosome in addition to chromosomes 9 and 22. We describe five male patients in the chronic myeloid leukemia-chronic phase, with rare variant Philadelphia translocations. All of them had the BCR-ABL fusion gene and responded well to treatment with imatinib mesylate. All the patients are on regular follow-up.
authors.affiliation: Department of Pathology, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, India.
authors.forename: Vijaya V
authors.initials: VV
authors.lastname: Mysorekar
authors.forename: Murali
authors.initials: M
authors.lastname: Subramanian
authors.forename: Nalini
authors.initials: N
authors.lastname: Kilara
authors.forename: Tambarahalli S
authors.initials: TS
authors.lastname: Sundareshan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic