title: Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome.
abstract: Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B-cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.
authors.affiliation: Human Genetics Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Robert Tanner
authors.initials: RT
authors.lastname: Hagelstrom
authors.affiliation: Pediatric Oncology/ Hematology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: James
authors.initials: J
authors.lastname: Ford
authors.affiliation: Genetic Medicine, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Gwendolyn M
authors.initials: GM
authors.lastname: Reiser
authors.affiliation: Human Genetics Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Marilu
authors.initials: M
authors.lastname: Nelson
authors.affiliation: Human Genetics Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Diane L
authors.initials: DL
authors.lastname: Pickering
authors.affiliation: Human Genetics Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Althof
authors.affiliation: Human Genetics Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Warren G
authors.initials: WG
authors.lastname: Sanger
authors.affiliation: Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Peter F
authors.initials: PF
authors.lastname: Coccia
mesh_terms: D000328:Adult; D018567:Breast Neoplasms, Male / Q000150:complications*; D002648:Child; D006223:Hamartoma Syndrome, Multiple / Q000150:complications* / Q000235:genetics; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D010375:Pedigree
keywords: B-cell lymphoblastic lymphoma; Cowden syndrome; PTEN; male breast cancer