title: Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases.
abstract: Sphingosine-1-phosphate (S1P) signaling is reported in variety of cell types, including immune, endothelial and cancerous cells. It is emerging as a crucial regulator of cellular processes, such as apoptosis, cell proliferation, migration, differentiation and so on. This signaling pathway is initiated by the intracellular production and secretion of S1P through a cascade of enzymatic reactions. Binding of S1P to different S1P receptors (S1PRs) activates different downstream signaling pathways that regulate the cellular functions differentially depending upon the cell type. An accumulating body of evidence suggests that S1P metabolism and signaling is often impaired during infectious diseases; thus, its manipulation might be helpful in the treatment of such diseases. In this review, we summarize recent advances in our understanding of the S1P signaling pathway and its candidature as a novel drug target against infectious diseases.
authors.affiliation: Infection and Immunity Lab, Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi 110025, India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Arish
authors.affiliation: Infection and Immunity Lab, Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi 110025, India.
authors.forename: Atahar
authors.initials: A
authors.lastname: Husein
authors.affiliation: Infection and Immunity Lab, Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi 110025, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kashif
authors.affiliation: Department of Life Sciences, National Institute of Technology, Rourkela, Odisha 769008, India.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Saleem
authors.affiliation: School of Life Sciences, Central University of Himachal Pradesh, Temporary Academic Block, Shahpur, Kangra, HP 176216, India.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Akhter
authors.affiliation: Infection and Immunity Lab, Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi 110025, India. Electronic address: arub@jmi.ac.in.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rub
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D003141:Communicable Diseases / Q000188:drug therapy* / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods; D008246:Lysophospholipids / Q000378:metabolism*; D049349:Receptors, Lysosphingolipid / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine