title: Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study.
abstract: Although the ketogenic diet has shown promise in a pilot study and case report in schizophrenia, its effects in animal models of hypothesized disease mechanisms are unknown. This study examined effects of treatment with the ketogenic diet on hippocampal P20/N40 gating in DBA/2 mice, a translational endophenotype that mirrors inhibitory deficits in P50 sensory gating in schizophrenia patients. As expected, the diet increased blood ketone levels. Animals with the highest ketone levels showed the lowest P20/N40 gating ratios. These preliminary results suggest that the ketogenic diet may effectively target sensory gating deficits and is a promising area for additional research in schizophrenia.
authors.affiliation: Research Service, Denver VA Medical Center, Denver, CO, USA; Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: Jason.Tregellas@ucdenver.edu.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Tregellas
authors.affiliation: Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Smucny
authors.affiliation: Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
authors.forename: Kristina T
authors.initials: KT
authors.lastname: Legget
authors.affiliation: Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Stevens
mesh_terms: D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D055423:Diet, Ketogenic; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D007659:Ketones / Q000097:blood; D008297:Male; D051379:Mice; D009433:Neural Inhibition / Q000187:drug effects; D018408:Patch-Clamp Techniques; D055139:Sensory Gating / Q000187:drug effects* / Q000502:physiology
chemical_list: D007659:Ketones
keywords: Gating; Hippocampus; Ketogenic diet; P50; Schizophrenia