title: Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine.
abstract: The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation. zgn@pharm.tsu.ru.|National Research Tomsk State University, Tomsk, Russian Federation. zgn@pharm.tsu.ru.
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: T Yu
authors.initials: TY
authors.lastname: Polyakova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.|National Research Tomsk State University, Tomsk, Russian Federation.
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.affiliation: N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.affiliation: N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Shul'ts
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: Ya V
authors.initials: YV
authors.lastname: Burmina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russian Federation.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000262:Adenylyl Cyclases / Q000235:genetics* / Q000378:metabolism; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D000242:Cyclic AMP / Q000037:antagonists & inhibitors / Q000378:metabolism*; D016048:Dideoxyadenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005786:Gene Expression Regulation; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D061251:Primary Cell Culture; D015398:Signal Transduction; D013234:Stem Cells; D013876:Thiophenes / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D004791:Enzyme Inhibitors; D013876:Thiophenes; D016048:Dideoxyadenosine; C057217:songorine; C021008:2',5'-dideoxyadenosine; D000242:Cyclic AMP; D051550:I-kappa B Kinase; C496562:Ikbkb protein, mouse; D000262:Adenylyl Cyclases
keywords: IKK; alkaloids; cAMP; progenitor cells; regenerative medicine