title: Viruses that ride on the coat-tails of actin nucleation.
abstract: Actin nucleation drives a diversity of critical cellular processes and the motility of a select group of viral pathogens. Vaccinia virus and baculovirus, Autographa californica multiple nucleopolyhedrovirus, recruit and activate the cellular actin nucleator, the Arp2/3 complex, at the surface of virus particles thereby instigating highly localized actin nucleation. The extension of these filaments provides a mechanical force that bestows the ability to navigate the intracellular environment and promote their infectious cycles. This review outlines the viral and cellular proteins that initiate and regulate the signalling networks leading to viral modification of the actin cytoskeleton and summarizes recent insights into the role of actin-based virus transport.
authors.affiliation: School of Molecular Bioscience, The University of Sydney, Sydney, NSW, 2006, Australia. Electronic address: tim.newsome@sydney.edu.au.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Newsome
authors.affiliation: School of Molecular Bioscience, The University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: N Bishara
authors.initials: NB
authors.lastname: Marzook
mesh_terms: D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D054884:Host-Pathogen Interactions; D006801:Humans; D008954:Models, Biological; D017924:Nucleopolyhedroviruses / Q000378:metabolism* / Q000502:physiology; D014616:Vaccinia virus / Q000378:metabolism* / Q000502:physiology; D014777:Virus Diseases / Q000378:metabolism* / Q000821:virology
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins
keywords: Actin; Arp2/3 complex; Baculovirus; Cytoskeleton; Microtubules; N-WASP; Vaccinia; Virus transport