title: A computational spinal motion segment model incorporating a matrix composition-based model of the intervertebral disc.
abstract: The extracellular matrix of the intervertebral disc is subjected to changes with age and degeneration, affecting the biomechanical behaviour of the spine. In this study, a finite element model of a generic spinal motion segment that links spinal biomechanics and intervertebral disc biochemical composition was developed. The local mechanical properties of the tissue were described by the local matrix composition, i.e. fixed charge density, amount of water and collagen and their organisation. The constitutive properties of the biochemical constituents were determined by fitting numerical responses to experimental measurements derived from literature. This general multi-scale model of the disc provides the possibility to evaluate the relation between local disc biochemical composition and spinal biomechanics.
authors.affiliation: Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: V M P
authors.initials: VM
authors.lastname: Barthelemy
authors.affiliation: Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: M M
authors.initials: MM
authors.lastname: van Rijsbergen
authors.affiliation: Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Wilson
authors.affiliation: Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Huyghe
authors.affiliation: Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: van Rietbergen
authors.affiliation: Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. Electronic address: k.ito@tue.nl.
authors.forename: K
authors.initials: K
authors.lastname: Ito
mesh_terms: D001696:Biomechanical Phenomena; D005109:Extracellular Matrix / Q000378:metabolism*; D020342:Finite Element Analysis; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology* / Q000503:physiopathology*; D055959:Intervertebral Disc Degeneration / Q000473:pathology / Q000503:physiopathology; D008159:Lumbar Vertebrae / Q000503:physiopathology*; D055595:Mechanical Phenomena; D008954:Models, Biological; D009068:Movement; D016474:Weight-Bearing
keywords: Biochemical composition; Finite element analysis; Intervertebral disc; Spinal motion segment