title: Contemporary Systemic Therapy for Urologic Malignancies in Geriatric Patients.
abstract: Current data on systemic therapy in geriatric populations with genitourinary malignancies are largely derived from retrospective analyses of prospectively conducted trials or retrospective reviews. Although extrapolation of these data to real-world patients should be cautious, patients aged 65 years or older with good functional status and minimal comorbidities seem to enjoy similar survival benefit from therapy as their younger counterparts. Chronologic age alone should generally not be used to guide management decisions. Comprehensive geriatric assessment tools and prospective studies in older adults integrating comprehensive geriatric assessment can shed light on the optimal management of urologic malignancies in this population.
authors.affiliation: Department of Hematology/Oncology, Taussig Cancer Institute, Cleveland Clinic, Desk R30, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Department of Hematology/Oncology, Taussig Cancer Institute, Cleveland Clinic, Desk R35, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: grivasp@ccf.org.
authors.forename: Petros D
authors.initials: PD
authors.lastname: Grivas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000628:therapy*; D003657:Decision Making; D019468:Disease Management; D005260:Female; D015577:Geriatric Assessment / Q000379:methods*; D005853:Geriatrics; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy*; D008297:Male; D009369:Neoplasms; D011471:Prostatic Neoplasms / Q000628:therapy*; D011788:Quality of Life; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
keywords: Bladder cancer; Geriatric assessment tools; Geriatric oncology; Kidney cancer; Prostate cancer; Renal cell carcinoma; Systemic therapy; Urothelial carcinoma