title: The InflammTORy Powers of Senescence.
abstract: Cellular senescence is accompanied by secretion of cytokines and ensuing inflammation. Recent work reveals that mTOR is crucial for the secretory phenotype of senescent cells. These findings open the possibility of disabling the pathological effects of senescence with mTOR inhibitors and may explain the anti-aging properties of rapamycin.
authors.affiliation: Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Electronic address: mserrano@cnio.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano
mesh_terms: D000818:Animals; D006801:Humans; D053582:Interleukin-1alpha / Q000378:metabolism*; D008297:Male; D011471:Prostatic Neoplasms / Q000201:enzymology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D053582:Interleukin-1alpha; D058570:TOR Serine-Threonine Kinases
keywords: aging; cancer; cytokines; inflammation; mTOR; senescence