title: When the Snake Lost Its Limbs, What Did the Mouse and Lizard Say?
abstract: In this issue of Developmental Cell, Infante et al. (2015) compare regulatory DNA sequences in mice, lizards, and limbless snakes to reveal widespread sharing of enhancer activity in developing limbs and genitalia. Genetic deletion of a limb-genital enhancer demonstrates that common regulatory elements affect development of both appendages.
authors.affiliation: University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK. Electronic address: diego.villarlozano@cruk.cam.ac.uk.
authors.forename: Diego
authors.initials: D
authors.lastname: Villar
authors.affiliation: University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. Electronic address: duncan.odom@cruk.cam.ac.uk.
authors.forename: Duncan T
authors.initials: DT
authors.lastname: Odom
mesh_terms: D000818:Animals; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D005121:Extremities / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D005835:Genitalia / Q000196:embryology*; D038081:Organogenesis / Q000502:physiology*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D020825:T-Box Domain Proteins / Q000502:physiology*
chemical_list: D020825:T-Box Domain Proteins