title: Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold.
abstract: A synthetic approach combining recent concepts for the preparation of multifunctional nanomolecules (click chemistry on multifunctional scaffolds) with supramolecular chemistry (self-assembly to prepare rotaxanes) gave easy access to a large variety of sophisticated [2]rotaxane heteroglycoclusters. Specifically, compounds combining galactose and fucose have been prepared to target the two bacterial lectins (LecA and LecB) from the opportunistic pathogen Pseudomonas aeruginosa.
authors.affiliation: University of Namur (UNamur), Académie Louvain, Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, 5000 Namur (Belgium). stephane.vincent@unamur.be.
authors.forename: Stéphane P
authors.initials: SP
authors.lastname: Vincent
authors.affiliation: University of Namur (UNamur), Académie Louvain, Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, 5000 Namur (Belgium).
authors.forename: Kevin
authors.initials: K
authors.lastname: Buffet
authors.affiliation: Laboratoire de Chimie des Matériaux Moléculaires, Université de Strasbourg et CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux (ECPM), 25 rue Becquerel, 67087 Strasbourg Cedex 2 (France).
authors.forename: Iwona
authors.initials: I
authors.lastname: Nierengarten
authors.affiliation: CERMAV (UPR5301), CNRS and Université Grenoble Alpes, BP 53, 38041, Grenoble (France). anne.imberty@cermav.cnrs.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Imberty
authors.affiliation: Laboratoire de Chimie des Matériaux Moléculaires, Université de Strasbourg et CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux (ECPM), 25 rue Becquerel, 67087 Strasbourg Cedex 2 (France). nierengarten@unistra.fr.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Nierengarten
mesh_terms: D001686:Biological Phenomena; D057930:Click Chemistry; D005690:Galactose / Q000737:chemistry*; D037102:Lectins / Q000737:chemistry*; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*
chemical_list: D037102:Lectins; D043862:Rotaxanes; D005690:Galactose
keywords: click chemistry; glycoclusters; lectin; pillar[5]arenes; rotaxane