title: The Role of Pathogen-Secreted Proteins in Fungal Vascular Wilt Diseases.
abstract: A limited number of fungi can cause wilting disease in plants through colonization of the vascular system, the most well-known being Verticillium dahliae and Fusarium oxysporum. Like all pathogenic microorganisms, vascular wilt fungi secrete proteins during host colonization. Whole-genome sequencing and proteomics screens have identified many of these proteins, including small, usually cysteine-rich proteins, necrosis-inducing proteins and enzymes. Gene deletion experiments have provided evidence that some of these proteins are required for pathogenicity, while the role of other secreted proteins remains enigmatic. On the other hand, the plant immune system can recognize some secreted proteins or their actions, resulting in disease resistance. We give an overview of proteins currently known to be secreted by vascular wilt fungi and discuss their role in pathogenicity and plant immunity.
authors.affiliation: Molecular Plant Pathology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098XH, The Netherlands. m.desain@uva.nl.
authors.forename: Mara
authors.initials: M
authors.lastname: de Sain
authors.affiliation: Molecular Plant Pathology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098XH, The Netherlands. m.rep@uva.nl.
authors.forename: Martijn
authors.initials: M
authors.lastname: Rep
mesh_terms: D060467:Disease Resistance / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005670:Fusarium / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D016681:Genome, Fungal; D055156:Ophiostoma / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D010935:Plant Diseases / Q000382:microbiology*; D010944:Plants / Q000276:immunology / Q000382:microbiology; D012988:Soil Microbiology; D020172:Verticillium / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*
chemical_list: D005656:Fungal Proteins
keywords: avirulence; effectors; pathogenicity; secreted proteins; vascular wilt fungi; virulence