title: [CHANGES IN COLON MICROBIOCENOSIS COMPOSITION AND ANTIOXIDANT PROPERTIES OF COLONOCYTES UNDER THE CONDITION OF EXPERIMENTAL DYSBIOSIS AND EMOXIPIN PROPHYLAXIS].
abstract: OBJECTIVE
  Study the composition of colon microbiocenosis and antioxidant properties of colonocytes under the conditions of experimental dysbiosis and prophylaxis application of emoxipin.
  
  
  METHODS
  With the aim of prophylaxis, antioxidant emoxipin was administered to mice, in which medicinal dysbiosis was formed by intraperitoneal administration of gentamicin. Quantitative and qualitative study of mucous microflora of the mice colon was carried out by a bacteriological method. The state of lipid peroxidation system was judged by the content of acylhydroperoxides and malonic dialdehyde, system of antioxidant protection--by enzyme activity (catalase and superoxide dismutase).
  
  
  RESULTS
  Experimental dysbiosis of the colon manifested by changes in the composition of mucous microflora of the animals and antioxidant properties of colonocytes. Dysbiosis prophylaxis by emoxipin resulted in normalization of the activity of antioxidant protection enzymes and products of lipid peroxidation in intestine tissue.
  
  
  CONCLUSIONS
  The study results allow to consider, that use of emoxipin results in an increase of adaptive-compensatory capabilities of the macroorganism during experimental dysbiosis.
authors.forename: A V
authors.initials: AV
authors.lastname: Ageichenko
authors.forename: P V
authors.initials: PV
authors.lastname: Kalutsky
authors.forename: O A
authors.initials: OA
authors.lastname: Medvedeva
authors.forename: V A
authors.initials: VA
authors.lastname: Korolev
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D003106:Colon / Q000378:metabolism / Q000382:microbiology; D064806:Dysbiosis / Q000139:chemically induced / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control; D005839:Gentamicins / Q000009:adverse effects* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D064307:Microbiota / Q000187:drug effects*; D010847:Picolines / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005839:Gentamicins; D010847:Picolines; C009820:6-methyl-2-ethyl-3-hydroxypyridine