title: Insulin-like growth factor 1 receptor (IGF1R) signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification.
authors.affiliation: Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany; Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Heilig
authors.affiliation: Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany; Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
authors.forename: Mats
authors.initials: M
authors.lastname: Paulsson
authors.affiliation: Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany; Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany. Electronic address: frank.zaucke@uni-koeln.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Zaucke
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001842:Bone and Bones / Q000473:pathology; D002113:Calcification, Physiologic; D002356:Cartilage / Q000196:embryology / Q000378:metabolism* / Q000473:pathology; D019902:Chondrocytes / Q000378:metabolism / Q000473:pathology; D024043:Collagen Type II / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D006984:Hypertrophy; D019426:Integrases / Q000378:metabolism; D053509:Matrix Metalloproteinase 13 / Q000378:metabolism; D008682:Metatarsal Bones / Q000196:embryology / Q000473:pathology; D008810:Mice, Inbred C57BL; D009924:Organ Culture Techniques; D010012:Osteogenesis; D017526:Receptor, IGF Type 1 / Q000172:deficiency / Q000378:metabolism*; D015398:Signal Transduction; D000076182:Sp7 Transcription Factor; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D024043:Collagen Type II; D000076182:Sp7 Transcription Factor; C479466:Sp7 protein, mouse; D014157:Transcription Factors; D017526:Receptor, IGF Type 1; C045073:Cre recombinase; D019426:Integrases; D000469:Alkaline Phosphatase; D053509:Matrix Metalloproteinase 13
keywords: Chondrocytes; Growth plate; IGF1; Matrix mineralization; Osterix