title: Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease.
abstract: Angiotensin-converting enzyme (ACE) has shown altered activity in patients with neurological diseases. An insertion/deletion (I/D) polymorphism of the ACE gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer's disease (AD), and is generally considered to be a disorder primarily affecting memory. We conducted a case-control study in a sample composed of 85 sporadic AD patients and 90 age- and sex-matched controls to investigate the possible effect of the polymorphism and cognitive profile. Our data revealed an association between the ACE polymorphism and AD risk. There was a significant difference in the ACE allele or genotype frequencies between cases and controls. The D/D genotype showed an increased risk for AD and in the amnestic group and the effect was independent on ApoE genotypes.
authors.affiliation: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia. achouriafef@yahoo.fr.|Biochemistry and Molecular Biology Laboratory, Children's Hospital, Bab Saadoun 1029, Tunis, Tunisia. achouriafef@yahoo.fr.
authors.forename: Afef
authors.initials: A
authors.lastname: Achouri-Rassas
authors.affiliation: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.
authors.forename: Nadia Ben
authors.initials: NB
authors.lastname: Ali
authors.affiliation: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.
authors.forename: Aroua
authors.initials: A
authors.lastname: Cherif
authors.affiliation: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.
authors.forename: Saloua
authors.initials: S
authors.lastname: Fray
authors.affiliation: Biochemistry and Molecular Biology Laboratory, Children's Hospital, Bab Saadoun 1029, Tunis, Tunisia.
authors.forename: Hajer
authors.initials: H
authors.lastname: Siala
authors.affiliation: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.
authors.forename: Nouria Oudiaa
authors.initials: NO
authors.lastname: Zakraoui
authors.affiliation: Biochemistry and Molecular Biology Laboratory, Children's Hospital, Bab Saadoun 1029, Tunis, Tunisia.
authors.forename: Sondes
authors.initials: S
authors.lastname: Hadj-Fredj
authors.affiliation: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.
authors.forename: Mariem
authors.initials: M
authors.lastname: Kechaou
authors.affiliation: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.
authors.forename: Nadia
authors.initials: N
authors.lastname: Anane
authors.affiliation: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.
authors.forename: Slim
authors.initials: S
authors.lastname: Echebi
authors.affiliation: Biochemistry and Molecular Biology Laboratory, Children's Hospital, Bab Saadoun 1029, Tunis, Tunisia.
authors.forename: Taieb
authors.initials: T
authors.lastname: Messaoud
authors.affiliation: Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia.
authors.forename: Samir
authors.initials: S
authors.lastname: Belal
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D016022:Case-Control Studies; D003071:Cognition; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014416:Tunisia
chemical_list: D053327:Apolipoprotein E4; D007703:Peptidyl-Dipeptidase A
keywords: ACE; Alzheimer disease; Apolipoprotein E; Cognitive profile; Polymorphism