title: Potential Role of Catecholamine Response to Acute Hypoxia in the Modification of the Effects of Radioprotectors.
abstract: Involvement of hormonal response (catecholamine release) to acute hypoxia induced by radioprotectors in modification of their radioprotective properties was studied in experiments on outbred mature female albino mice, female albino rats, and dogs of both sexes. The response intensity was evaluated by the reduction of radioprotective and toxic properties of indralin (a α1-adrenoceptor agonist and a radioprotector). The radioprotective effect of indralin was measured using lethal doses of whole-body γ-irradiation ((60)Co) and its acute toxicity was assessed by LD50. It was found that repeated administration of indralin with 30-60-min intervals was followed by weakening of its radioprotective effect. Similar sensitization effect of indralin was observed after pretreatment with cystamine and epinephrine. Comparison of the severity of sensitization after administration of epinephrine and cystamine in the dose providing radioprotective effect showed that the potential aminothiol-induced release of catecholamines can provide optimal long-term radioprotective effect of epinephrine.
authors.affiliation: State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia. mikhail-v-vasin@yandex.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Vasin
authors.affiliation: State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Ushakov
authors.affiliation: State Scientific Centre Institute of Medical and Biological Problems, Russian Academy of Sciences, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Antipov
mesh_terms: D008735:5-Methoxytryptamine / Q000494:pharmacology; D058646:Adrenergic alpha-1 Receptor Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D021461:Animals, Outbred Strains; D003538:Cystamine / Q000494:pharmacology*; D004285:Dogs; D004334:Drug Administration Schedule; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D000860:Hypoxia / Q000097:blood / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010636:Phenols / Q000008:administration & dosage* / Q000009:adverse effects; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000009:adverse effects; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000097:blood; D016019:Survival Analysis; D014916:Whole-Body Irradiation
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D010636:Phenols; D011837:Radiation-Protective Agents; D018340:Receptors, Adrenergic, alpha-1; C086896:indralin; D008735:5-Methoxytryptamine; D003538:Cystamine; D004837:Epinephrine
keywords: cystamine; desensitization; epinephrine; indralin; radioprotective effects