title: Brattleboro Rats as the Model of Blood Hyperviscosity Syndrome for Testing Substances with Hemorheological Activity.
abstract: Hyperviscosity syndrome was described in Brattleboro rats. The aim of this study was to investigate the possibility of Brattleboro rats using, as a test system for the study of agents with hemorheological activity. Under conditions of this model of high blood viscosity syndrome in Brattleboro rats, Lychnis chalcedonica L. extract (150 mg/kg) administered intragastrically for 10 days exhibited hemorheological activity by modulating macro- (plasma viscosity, fibrinogen concentration) and microrheological (erythrocyte aggregation and deformability parameters. Hence, Brattleboro rats are an adequate model of hyperviscosity syndrome that can be used for search and testing of substances with hemorheological activity.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. mbp2001@mail.ru.|National Research Tomsk State University, Tomsk, Russia. mbp2001@mail.ru.
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Vasil'ev
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.|National Research Tomsk State University, Tomsk, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Aliev
authors.affiliation: National Research Tomsk State University, Tomsk, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Zibareva
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D006401:Hematologic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011910:Rats, Brattleboro; D017208:Rats, Wistar; D029751:Silene; D013045:Species Specificity; D013577:Syndrome
chemical_list: D006401:Hematologic Agents; D010936:Plant Extracts; C504810:scarlet lightning extract; D005340:Fibrinogen
keywords: Brattleboro rats; Lychnis chalcedonica extract; erythrocyte aggregation and deformability; hereditary hypothalamic diabetes insipidus; high blood viscosity syndrome