title: [Association of adipocytokines with obesity and insulin resistance in Korean-Chinese and Han nationality pupils of Yanbian area].
abstract: OBJECTIVE
  To investigate the different types of obesity, insulin resistance (IR) and its related adipocytokines, and to analyze the association of adipocytokines with obesity and insulin resistance in Korean-Chinese and Han nationality pupils of Yanbian area.
  
  
  METHODS
  A total of 3879 elementary school students (2011 of Korean-Chinese and 1868 of Han nationality) aged 8-12 years old were selected. Using epidemiological investigation. Combined with laboratory measurement, the body mess index ( BMI), waist circumference (WC) and fasting blood glucose (FBG), insulin, adiponectin, leptin and tumor necrosis factor-alpha (TNF-α) levels were measured. The homeostasis model assessment (HOMA) method was used to estimate the human IR (HOMA-IR).
  
  
  RESULTS
  (1) The levels of adiponctin and TNF-α in Korean-Chinese pupils was lower than that in Han nationality pupils (P < 0.01), and the levels of leptin, HOMA-IR, WC and BMI in Korean-Chinese pupils were higher than that in Han nationality pupils (P < 0.01). (2) BMI, WC and HOMA-IR was negatively related with adiponectin (r = -0.178, -0.172 and -0.137, P < 0.001), and that were positively related with leptin (r = 0.572, 0.535 and 0.265, P < 0.001) and TNF-α (r = 0.110, 0.119 and 0.691, P < 0.001). There were nationality differences in the correlation of BMI, WC ard HOMA-IR in the different adipocytokines. (3) The multivariate regression analysis showed that there was a significant linear regression between BMI, WG and HOMA--IR and adiponectin (Beta = -0.022, -0.019 and -0.042), leptin (Beta = 0.154, 0.069 and 0.039) and TNF-α ( Beta = -0.082, 0.018 and 0.654), there were different association of BMI, WC and HOMA-IR in the different adipocytokines.
  
  
  CONCLUSIONS
  There is significant difference for the distribution of obesity, HOMA-IR and its related adipocytokines between two nationality pupils of Yanbian area. BMI, WC and HOMA-IR have different association in the different adipocytokines, and the association of BMI and WC in leptin is stronger than that of HOMA-IR, and that of HOMA-IR in TNF-α and adiponectin is stronger than that of BMI and WC.
authors.forename: Yongzhe
authors.initials: Y
authors.lastname: Jing
authors.forename: Shanji
authors.initials: S
authors.lastname: Jin
authors.forename: Ranzhuo
authors.initials: R
authors.lastname: Qiao
authors.forename: Jinnü
authors.initials: J
authors.lastname: Fang
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D044466:Asian People / Q000208:ethnology / Q000706:statistics & numerical data*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D005006:Ethnicity / Q000706:statistics & numerical data*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D009765:Obesity / Q000097:blood / Q000208:ethnology*; D056910:Republic of Korea / Q000453:epidemiology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism; D055105:Waist Circumference
chemical_list: D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha