title: Analysis of cell-mediated immune responses in support of dengue vaccine development efforts.
abstract: Dengue vaccine development has made significant strides, but a better understanding of how vaccine-induced immune responses correlate with vaccine efficacy can greatly accelerate development, testing, and deployment as well as ameliorate potential risks and safety concerns. Advances in basic immunology knowledge and techniques have already improved our understanding of cell-mediated immunity of natural dengue virus infection and vaccination. We conclude that the evidence base is adequate to argue for inclusion of assessments of cell-mediated immunity as part of clinical trials of dengue vaccines, although further research to identify useful correlates of protective immunity is needed.
authors.affiliation: Institute for Immunology and Informatics and Department of Cell and Molecular Biology, University of Rhode Island, 80 Washington St., Providence, RI 02903, USA. Electronic address: alan_rothman@uri.edu.
authors.forename: Alan L
authors.initials: AL
authors.lastname: Rothman
authors.affiliation: Virus Diseases Branch, Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD, USA. Electronic address: jeffrey.r.currier.ctr@mail.mil.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Currier
authors.affiliation: Virus Diseases Branch, Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD, USA. Electronic address: heather.l.friberg-robertson.ctr@mail.mil.
authors.forename: Heather L
authors.initials: HL
authors.lastname: Friberg
authors.affiliation: Institute for Immunology and Informatics and Department of Cell and Molecular Biology, University of Rhode Island, 80 Washington St., Providence, RI 02903, USA. Electronic address: mathewa@uri.edu.
authors.forename: Anuja
authors.initials: A
authors.lastname: Mathew
mesh_terms: D000818:Animals; D003715:Dengue / Q000276:immunology*; D053059:Dengue Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular
chemical_list: D053059:Dengue Vaccines
keywords: Cell-mediated immunity; Dengue; Vaccine