title: Linker histones: History and current perspectives.
abstract: Although the overall structure of the fifth histone (linker histone, H1) is understood, its location on the nucleosome is only partially defined. Whilst it is clear that H1 helps condense the chromatin fibre, precisely how this is achieved remains to be determined. H1 is not a general gene repressor in that although it must be displaced from transcription start sites for activity to occur, there is only partial loss along the body of genes. How the deposition and removal of H1 occurs in particular need of further study. Linker histones are highly abundant nuclear proteins about which we know too little.
authors.affiliation: Biophysics Laboratories, School of Biology, University of Portsmouth, PO1 2DT, UK.
authors.forename: C
authors.initials: C
authors.lastname: Crane-Robinson
mesh_terms: D000818:Animals; D002843:Chromatin / Q000502:physiology; D042002:Chromatin Assembly and Disassembly; D006657:Histones / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D006801:Humans; D017434:Protein Structure, Tertiary
chemical_list: D002843:Chromatin; D006657:Histones
keywords: Chromatin; Linker histone; Nucleosome