title: Local wound care and topical management of hidradenitis suppurativa.
abstract: Hidradenitis suppurativa (HS) is a chronic, recurrent, debilitating disease predominantly involving apocrine gland-bearing skin. The folliculoinfundibular dysfunction and an aberrant cutaneous immune response to commensal bacteria are recognized as potential contributors. Topical antibiotics, such as clindamycin, and keratolytic agents have been used in the management of early stages of HS. Proper wound care is a key part of management, particularly in patients with advanced HS. The evidence for the optimal topical therapy or optimal local wound care is limited. As such, a multidisciplinary approach is necessary to address all aspects of HS, including topical therapy, systemic therapy, and proper wound care. The focus of this paper is to review the evidence for the topical management and local wound care strategies in patients with HS.
authors.affiliation: Department of Medicine (Dermatology), University of Toronto, Toronto, Ontario, Canada. Electronic address: afsaneh.alavi@utoronto.ca.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Alavi
authors.affiliation: Department of Dermatology, University of Miami, Miami, Florida; Department of Cutaneous Surgery, University of Miami, Miami, Florida.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Kirsner
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D017497:Hidradenitis Suppurativa / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D011379:Prognosis; D012118:Resorcinols / Q000627:therapeutic use; D012176:Retinoids / Q000627:therapeutic use; D012720:Severity of Illness Index; D017592:Skin Care / Q000379:methods*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D007641:Keratolytic Agents; D012118:Resorcinols; D012176:Retinoids; D002981:Clindamycin; C031389:resorcinol
keywords: NPWT; clindamycin; hidradenitis suppurativa; resorcinol; retinoid; topical treatments