title: Distribution and Clinical Significance of High Signal Intensity of the Myocardium on T2-Weighted Images in 2 Phenotypes of Hypertrophic Cardiomyopathy.
abstract: OBJECTIVE
  The aim of this study was to evaluate distribution and clinical significance of high signal intensity of the myocardium on T2-weighted images (T2-HI) in 2 phenotypes of hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  Thirty-six patients with asymmetrical septal HCM (ASH) and 18 patients with apical HCM (APH) and their 864 myocardial segments were investigated. The distribution of T2-HI was compared with that of late gadolinium enhancement (LGE), and the relationships between T2-HI and clinical risk markers were evaluated. T2 values of the T2-HI were estimated with T2 mapping.
  
  
  RESULTS
  The T2-HI was observed in 18 segments (3.1%) in 13 patients with ASH (36.1%) and in 12 segments (4.2%) in 8 patients with APH (44.4%). It was often localized outside LGE. The presence of T2-HI was related to syncope in ASH (P = 0.016). Furthermore, it had higher T2 values (61.1 milliseconds) than the reference myocardium (47.3 milliseconds).
  
  
  CONCLUSIONS
  High signal intensity of the myocardium on T2-weighted images often locates outside LGE and reflects myocardial damage, which is related to syncope in ASH.
authors.affiliation: From the Departments of *Radiology and †Cardiology and Intensive Cardiac Care Unit, Nippon Medical School, Tokyo, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Amano
authors.forename: Kumiko
authors.initials: K
authors.lastname: Aita
authors.forename: Fumi
authors.initials: F
authors.lastname: Yamada
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Kitamura
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kumita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D015588:Observer Variation; D010641:Phenotype; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012306:Risk; D013575:Syncope; D020107:Troponin T / Q000097:blood*
chemical_list: D003287:Contrast Media; D020107:Troponin T; D019786:Gadolinium DTPA