title: Total Synthesis of Lignan Lactone (-)-Hinokinin.
abstract: This research paper is aimed at studying the total synthesis of pharmacologically active lignan (-)-hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal butyrolactonimidate intermediate.
authors.affiliation: Innovative Drug Research Centre, Chongqing University, Chongqing, 401331, China.
authors.forename: Qi-Long
authors.initials: QL
authors.lastname: Zhou
authors.affiliation: Innovative Drug Research Centre, Chongqing University, Chongqing, 401331, China.
authors.forename: Hui-Jing
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Innovative Drug Research Centre, Chongqing University, Chongqing, 401331, China. tangpei@cqu.edu.cn.
authors.forename: Pei
authors.initials: P
authors.lastname: Tang
authors.affiliation: Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Song
authors.affiliation: Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China. yongqin@scu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Qin
keywords: Cascade reaction; Hinokinin; Lignan; Total synthesis