title: Hilar cholangiocarcinoma with intratumoral calcification: A case report.
abstract: This report describes a rare case of hilar cholangiocarcinoma with intratumoral calcification that mimicked hepatolithiasis. A 73-year-old man presented to a local hospital with a calcified lesion in the hepatic hilum. At first, hepatolithiasis was diagnosed, and he underwent endoscopic stone extraction via the trans-papillary route. This treatment strategy failed due to biliary stricture. He was referred to our hospital, and further examination suggested the existence of cholangiocarcinoma. He underwent left hepatectomy with caudate lobectomy and extrahepatic bile duct resection. Pathological examination revealed hilar cholangiocarcinoma with intratumoral calcification, while no stones were found. To the best of our knowledge, only one case of calcified hilar cholangiocarcinoma has been previously reported in the literature. Here, we report a rare case of calcified hilar cholangiocarcinoma and reveal its clinicopathologic features.
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Kazuho
authors.initials: K
authors.lastname: Inoko
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuchikawa
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Noji
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Yo
authors.initials: Y
authors.lastname: Kurashima
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Yuma
authors.initials: Y
authors.lastname: Ebihara
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Tamoto
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Soichi
authors.initials: S
authors.lastname: Murakami
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Okamura
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shichinohe
authors.affiliation: Kazuho Inoko, Takahiro Tsuchikawa, Takehiro Noji, Yo Kurashima, Yuma Ebihara, Eiji Tamoto, Toru Nakamura, Soichi Murakami, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano, Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8648, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirano
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002114:Calcinosis / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D020347:Lithiasis / Q000175:diagnosis*; D008107:Liver Diseases / Q000175:diagnosis*; D008297:Male
keywords: Calcification; Cholangiocarcinoma; Differentiation; Klatskin tumor; Lithiasis