title: Dining in: intracellular bacterial pathogen interplay with autophagy.
abstract: Intracellular bacterial pathogens have evolved many ways to manipulate host cells for successful infection. Many of these pathogens use specialized secretion systems to inject bacterial proteins into the host cytosol that manipulate cellular processes to favor infection. Autophagy is a eukaryotic cellular remodeling process with a critical role in many diseases, including bacterial clearance. A growing field of research highlights mechanisms used by intracellular bacteria to manipulate autophagy as a pro-survival strategy. This review focuses on a select group of bacterial pathogens with diverse intracellular lifestyles that exploit autophagy-derived nutrients and membrane for survival. This group of pathogens uses secretion systems and specific effectors to subvert distinct components of autophagy. By understanding how intracellular pathogens manipulate autophagy, we gain insight not only into bacterial pathogenesis but also host cell signaling and autophagolysosome maturation.
authors.affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
authors.forename: Caylin G
authors.initials: CG
authors.lastname: Winchell
authors.affiliation: Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, United States.
authors.forename: Shaun
authors.initials: S
authors.lastname: Steele
authors.affiliation: Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, United States.
authors.forename: Tom
authors.initials: T
authors.lastname: Kawula
authors.affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States. Electronic address: dvoth@uams.edu.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Voth
mesh_terms: D001343:Autophagy; D001419:Bacteria / Q000254:growth & development / Q000378:metabolism* / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000378:metabolism; D058947:Bacterial Secretion Systems / Q000502:physiology*; D016997:Coxiella burnetii / Q000378:metabolism / Q000472:pathogenicity; D003593:Cytoplasm / Q000382:microbiology*; D005057:Eukaryotic Cells / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008247:Lysosomes / Q000382:microbiology / Q000502:physiology; D050296:Microbial Viability; D010588:Phagosomes / Q000382:microbiology; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems