title: Air Pollution modifies the association between successful and pathological aging throughout the frailty condition.
abstract: The rapid growth in the number of older adults has many implications for public health, including the need to better understand the risks posed by environmental exposures. Aging leads to a decline and deterioration of functional properties at the cellular, tissue and organ level. This loss of functional properties yields to a loss of homeostasis and decreased adaptability to internal and external stress. Frailty is a geriatric syndrome characterized by weakness, weight loss, and low activity that is associated with adverse health outcomes. Frailty manifests as an age-related, biological vulnerability to stressors and decreased physiological reserves. Ambient air pollution exposure affects human health, and elderly people appear to be particularly susceptible to its adverse effects. The aim of this paper is to discuss the role of air pollution in the modulation of several biological mechanisms involved in aging. Evidence is presented on how air pollution can modify the bidirectional association between successful and pathological aging throughout the frailty conditions.
authors.affiliation: Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France. Electronic address: b.fougere@gmail.com.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Fougère
authors.affiliation: Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (EA4492), Université du Littoral Côte d'Opale, Dunkerque, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Billet
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (EA4492), Université du Littoral Côte d'Opale, Dunkerque, France.
authors.forename: Perrine J
authors.initials: PJ
authors.lastname: Martin
authors.affiliation: Cognitive Impairment Centre, General Hospital of Treviso, Piazza Ospedale, 1, I-31100 Treviso, Italy; FORGEI, Interdisciplinary Geriatric Research Foundation, Viale Trento Trieste 19, I-31100 Treviso, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Gallucci
authors.affiliation: Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.
authors.forename: Matteo
authors.initials: M
authors.lastname: Cesari
mesh_terms: D000222:Adaptation, Physiological; D000368:Aged; D000375:Aging / Q000502:physiology*; D000397:Air Pollution / Q000009:adverse effects*; D015987:Effect Modifier, Epidemiologic; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis / Q000517:prevention & control; D016330:Frail Elderly / Q000706:statistics & numerical data*; D006801:Humans; D052638:Particulate Matter / Q000009:adverse effects
chemical_list: D052638:Particulate Matter
keywords: Aging; Air pollution; Biological mechanisms; Frailty; Particulate matter