title: A smart magnetic nanoplatform for synergistic anticancer therapy: manoeuvring mussel-inspired functional magnetic nanoparticles for pH responsive anticancer drug delivery and hyperthermia.
abstract: We report the versatile design of a smart nanoplatform for thermo-chemotherapy treatment of cancer. For the first time in the literature, our design takes advantage of the outstanding properties of mussel-inspired multiple catecholic groups - presenting a unique copolymer poly(2-hydroxyethyl methacrylate-co-dopamine methacrylamide) p(HEMA-co-DMA) to surface functionalize the superparamagnetic iron oxide nanoparticles as well as to conjugate borate containing anticancer drug bortezomib (BTZ) in a pH-dependent manner for the synergistic anticancer treatment. The unique multiple anchoring groups can be used to substantially improve the affinity of the ligands to the surfaces of the nanoparticles to form ultrastable iron oxide nanoparticles with control over their hydrodynamic diameter and interfacial chemistry. Thus the BTZ-incorporated-bio-inspired-smart magnetic nanoplatform will act as a hyperthermic agent that delivers heat when an alternating magnetic field is applied while the BTZ-bound catechol moieties act as chemotherapeutic agents in a cancer environment by providing pH-dependent drug release for the synergistic thermo-chemotherapy application. The anticancer efficacy of these bio-inspired multifunctional smart magnetic nanoparticles was tested both in vitro and in vivo and found that these unique magnetic nanoplatforms can be established to endow for the next generation of nanomedicine for efficient and safe cancer therapy.
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors.forename: Arathyram Ramachandra Kurup
authors.initials: AR
authors.lastname: Sasikala
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors.forename: Amin
authors.initials: A
authors.lastname: GhavamiNejad
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea and Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea. chskim@jbnu.ac.kr biochan@jbnu.ac.kr afeesh@jbnu.ac.kr afeeshnano@gmail.com.
authors.forename: Afeesh Rajan
authors.initials: AR
authors.lastname: Unnithan
authors.affiliation: Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Reju George
authors.initials: RG
authors.lastname: Thomas
authors.affiliation: DKC Corporation (BioActs), Incheon, South Korea.
authors.forename: Myeongju
authors.initials: M
authors.lastname: Moon
authors.affiliation: Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Jeong
authors.affiliation: Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea. chskim@jbnu.ac.kr biochan@jbnu.ac.kr afeesh@jbnu.ac.kr afeeshnano@gmail.com.
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea and Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea. chskim@jbnu.ac.kr biochan@jbnu.ac.kr afeesh@jbnu.ac.kr afeeshnano@gmail.com.
authors.forename: Cheol Sang
authors.initials: CS
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000069286:Bortezomib / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology; D006979:Hyperthermia, Induced / Q000379:methods*; D060526:Magnetic Fields; D008689:Methacrylates / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D005290:Ferric Compounds; D008689:Methacrylates; C000499:ferric oxide; D000069286:Bortezomib; C005044:hydroxyethyl methacrylate