title: Association between interluekin-17 gene polymorphisms and the risk of cervical cancer in a Chinese population.
abstract: We conducted a study to analyze the association of three common SNPs of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 gene polymorphisms with the risk of cervical cancer in a Chinese population. Our study included 352 cervical cancer patients and 352 controls between January 2013 and December 2014. Genotyping of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 genes was performed by multiplex PCR assays using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). By χ(2) test, there was significantly difference in the genotype distribution of IL-17A rs2275913 between cervical cancer patients and control subjects (χ(2)=11.45, P=0.003). By conditional logistic regression analysis, we found that individuals with the GA and AA genotypes were associated with an increased risk of cervical cancer when compared with the GG genotype in codominant model, and the adjusted Ors (95% CI) were 1.57 (1.13-2.18) and 2.01 (1.15-3.49), respectively. In dominant model, we found that the GA+AA genotype of rs2275913 was correlated with a moderate increased risk of cervical cancer compared with the GG genotype (OR=1.64, 95% CI=1.20-2.24). We only found significant interaction between rs2275913 polymorphism and HPV-16 or 18 infection in the risk of cervical cancer (P for interaction <0.05). In conclusion, our study suggests that IL-17A rs2275913 polymorphism may affect the development of cervical cancer in codominant and dominant models, and this gene polymorphism has interaction with HPV-16 or 18 infection.
authors.affiliation: Department of Gynaecology, Qilu Hospital, Shandong University China ; Department of Gynaecology, Qingdao University Affiliated Yantai Yuhuangding Hospital China.
authors.forename: Jianglin
authors.initials: J
authors.lastname: Cong
authors.affiliation: Department of Laboratory, Qingdao University Affiliated Yantai Yuhuangding Hospital China.
authors.forename: Riming
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Gynaecology, Qingdao University Affiliated Yantai Yuhuangding Hospital China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Laboratory, Qingdao University Affiliated Yantai Yuhuangding Hospital China.
authors.forename: Li
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Department of Gynaecology, Qingdao University Affiliated Yantai Yuhuangding Hospital China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Laboratory, Qingdao University Affiliated Yantai Yuhuangding Hospital China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Gynaecology, Qilu Hospital, Shandong University China.
authors.forename: Youzhong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Health and Social Behavior, West China School of Public Health, Sichuan University China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Health and Social Behavior, West China School of Public Health, Sichuan University China.
authors.forename: Chaoying
authors.initials: C
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D052162:Human papillomavirus 16; D052161:Human papillomavirus 18; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D030361:Papillomavirus Infections / Q000150:complications; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000821:virology
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17
keywords: Interluekin-17; cervical cancer; polymorphism