title: Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology.
abstract: On the model of chronic obstructive pulmonary disease, the effect of therapy with low-molecular-weight peptides on restructuring and functional activity of bronchial epithelium for restoring the immune and barrier function of the lungs and prevention of inflammatory process progression was studied. Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2. Administration of tetrapeptide Bronchogen for 1 month eliminates symptoms of remodeling of the bronchial epithelium and lung tissue typical of chronic obstructive pulmonary disease (goblet cell hyperplasia, squamous metaplasia, lymphocytic infiltration and emphysema, and restoration of ciliated cells). Enhanced production of secretory IgA, a local immunity marker, attested to normalization of functional activity of bronchial epithelium, while normalization of cell composition and profile of proinflammatory cytokines in the bronchoalveolar space reflected reduction of neutrophilic inflammation.
authors.affiliation: Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Kuzubova
authors.affiliation: Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia. osmelena@mail.ru.
authors.forename: E S
authors.initials: ES
authors.lastname: Lebedeva
authors.affiliation: Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Dvorakovskaya
authors.affiliation: Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Surkova
authors.affiliation: Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Platonova
authors.affiliation: Research Institute of Pulmonology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
authors.forename: O N
authors.initials: ON
authors.lastname: Titova
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002923:Cilia / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D020397:Goblet Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D006965:Hyperplasia / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D007070:Immunoglobulin A / Q000096:biosynthesis; D016209:Interleukin-8 / Q000096:biosynthesis / Q000276:immunology; D019272:Leukocyte Elastase / Q000096:biosynthesis / Q000276:immunology; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D020556:Neutrophil Infiltration / Q000187:drug effects; D009585:Nitrogen Dioxide; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D020545:Respiratory Mucosa / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D019141:Respiratory System Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D016209:Interleukin-8; D009842:Oligopeptides; D019141:Respiratory System Agents; D014409:Tumor Necrosis Factor-alpha; D019272:Leukocyte Elastase; D009585:Nitrogen Dioxide
keywords: bronchial epithelium; chronic obstructive pulmonary disease; regulatory peptides, inflammation