title: Two new γ-pyrone glucosides from Paeonia albiflora.
abstract: Two new γ-pyrone glucosides, along with three known compounds, were isolated from the roots of Paeonia albiflora, and their structures were elucidated by spectral experiments, chemical analysis, and comparison with literature data. The structures of the new compounds were established as 2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6-O-α-L-rhamnopyranosyl-β-D-glucopyranoside (1), and 2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6-O-galloyl-β-D-glucopyranoside (2). The inhibitory activity on the release of TNF-α of compounds 1-5 was evaluated in vitro. This is the first report of the presence of γ-pyrone glucoside in P. albiflora.
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application , Guangdong Institute of Microbiology , Guangzhou 510000 , China.|b The Second Clinical College , Guangzhou University of Chinese Medicine , Guangzhou 510000 , China.
authors.forename: Shao-Dan
authors.initials: SD
authors.lastname: Chen
authors.affiliation: b The Second Clinical College , Guangzhou University of Chinese Medicine , Guangzhou 510000 , China.|c Lab of Chinese Materia Medica Preparation , Guangdong Province Academy of Chinese Medicine Science , Guangzhou 510000 , China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Wang
authors.affiliation: b The Second Clinical College , Guangzhou University of Chinese Medicine , Guangzhou 510000 , China.|c Lab of Chinese Materia Medica Preparation , Guangdong Province Academy of Chinese Medicine Science , Guangzhou 510000 , China.
authors.forename: Chuan-Jian
authors.initials: CJ
authors.lastname: Lu
authors.affiliation: b The Second Clinical College , Guangzhou University of Chinese Medicine , Guangzhou 510000 , China.|c Lab of Chinese Materia Medica Preparation , Guangdong Province Academy of Chinese Medicine Science , Guangzhou 510000 , China.
authors.forename: Rui-Zhi
authors.initials: RZ
authors.lastname: Zhao
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D029596:Paeonia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
chemical_list: C000608891:2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranoside; C000608892:2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6-O-galloyl-beta-D-glucopyranoside; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D011753:Pyrones; D014409:Tumor Necrosis Factor-alpha
keywords: Paeonia albiflora; chemical constituents; γ-pyrone glucosides