title: Single Nanoparticle to 3D Supercage: Framing for an Artificial Enzyme System.
abstract: A facile strategy has been developed to fabricate Cu(OH)2 supercages (SCs) as an artificial enzyme system with intrinsic peroxidase-mimic activities (PMA). SCs with high catalytic activity and excellent recyclability were generated via direct conversion of amorphous Cu(OH)2 nanoparticles (NPs) at room temperature. More specifically, the process that takes a single nanoparticle to a 3D supercage involves two basic steps. First, with addition of a copper-ammonia complex, the Cu(2+) ions that are located on the surface of amorphous Cu(OH)2 NPs would evolve into a fine lamellar structure by coordination and migration and eventually convert to 1D nanoribbons around the NPs. Second, accompanied by the migration of Cu(2+), a hollow cavity is generated in the inner NPs, such that a single nanoparticle eventually becomes a nanoribbon-assembled 3D hollow cage. These Cu(OH)2 SCs were then engineered as an artificial enzymatic system with higher efficiency for intrinsic PMA than the peroxidase activity of a natural enzyme, horseradish peroxidase.
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Ren
authors.initials: R
authors.lastname: Cai
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University , 50 Nanyang Avenue, Singapore 639798.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University , 50 Nanyang Avenue, Singapore 639798.
authors.forename: Shengjie
authors.initials: S
authors.lastname: Peng
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Xigao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Weijia
authors.initials: W
authors.lastname: Hou
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida , Gainesville, Florida 32611-7200, United States.|College of Public Health, University of South China , Hengyang 421001, China.
authors.forename: Shengyuan
authors.initials: S
authors.lastname: Yang
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Zhenbao
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida , Gainesville, Florida 32611-7200, United States.|Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University , Changsha 410082, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism; D006878:Hydroxides / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D006878:Hydroxides; C508959:copper hydroxide; D003300:Copper; D006735:Horseradish Peroxidase