title: Comparison of Immunohistochemical Expression of Antiapoptotic Protein Survivin in Normal Oral Mucosa, Oral Leukoplakia, and Oral Squamous Cell Carcinoma.
abstract: Background. Oral squamous cell carcinoma is the sixth most frequent malignant tumor worldwide and the third most common cancers in developing countries. Oral leukoplakia is the best-known precursor lesion of oral squamous cell carcinoma. The aim of the present study was to compare immunohistochemical expression of antiapoptotic protein survivin in normal oral mucosa, oral leukoplakia, and oral squamous cell carcinoma. Method. Total 45 specimens of formalin fixed paraffin embedded tissue blocks, 15 in each of the following: normal oral mucosa, leukoplakia, and oral squamous cell carcinoma were used for the study. Immunohistochemical reaction for survivin protein was performed for the 4 µm thick histological sections taken on positively charged slides. Results. 20% normal mucosa cases, 53.33% cases of leukoplakia, and 80% of oral squamous cell carcinoma were found out to be survivin positive. One way ANOVA test indicated statistically significant difference of survivin expression between the three different groups (p < 0.001). Conclusion. A high incidence of survivin protein expression in oral epithelial dysplasia and squamous cell carcinoma samples indicate that survivin protein expression may be an early event in initiation and progression of oral squamous cell carcinoma.
authors.affiliation: Department of Oral Pathology & Microbiology, Himachal Dental College, Sunder Nagar, District Mandi, Himachal Pradesh 175002, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Negi
authors.affiliation: Department of Oral Pathology & Microbiology, Himachal Institute of Dental Sciences, Paonta Sahib, District Sirmour, Himachal Pradesh 173025, India.
authors.forename: Abhiney
authors.initials: A
authors.lastname: Puri
authors.affiliation: Department of Oral Pathology & Microbiology, Himachal Institute of Dental Sciences, Paonta Sahib, District Sirmour, Himachal Pradesh 173025, India.
authors.forename: Rakhi
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Department of Oral Pathology & Microbiology, Himachal Institute of Dental Sciences, Paonta Sahib, District Sirmour, Himachal Pradesh 173025, India.
authors.forename: Rajat
authors.initials: R
authors.lastname: Nangia
authors.affiliation: Department of Oral Pathology & Microbiology, Himachal Institute of Dental Sciences, Paonta Sahib, District Sirmour, Himachal Pradesh 173025, India.
authors.forename: Alisha
authors.initials: A
authors.lastname: Sachdeva
authors.affiliation: Department of Oral Pathology & Microbiology, Himachal Institute of Dental Sciences, Paonta Sahib, District Sirmour, Himachal Pradesh 173025, India.
authors.forename: Megha
authors.initials: M
authors.lastname: Mittal