title: Intramolecular Fluorocyclizations of Unsaturated Carboxylic Acids with a Stable Hypervalent Fluoroiodane Reagent.
abstract: A new class of fluorinated lactones was prepared by the intramolecular fluorocyclizations of unsaturated carboxylic acids by using the stable fluoroiodane reagent in combination with AgBF4. This unique reaction incorporates a cyclization, an aryl migration, and a fluorination all in one step. The fluoroiodane reagent, prepared easily from fluoride, can also be used without a metal catalyst to give moderate yields within just 1 hour, thus demonstrating that it is a suitable reagent for developing new (18)F-labelled radiotracers for PET imaging.
authors.forename: Gemma C
authors.initials: GC
authors.lastname: Geary
authors.forename: Eric G
authors.initials: EG
authors.lastname: Hope
authors.affiliation: Department of Chemistry, University of Leicester, Leicester, LE1 7RH (UK). Alison.Stuart@le.ac.uk.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Stuart
keywords: cyclizations; fluorine; hypervalent compounds; lactones; silver