title: Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis.
abstract: Many factors are considered to contribute to hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation, and host susceptibility. HBV X protein (HBx) can interfere with several signaling pathways associated with cell proliferation and invasion, and HBx C-terminal truncation has been suggested to impact the development of HCC. This review focuses on the pathological functions of HBx in HBV-induced hepatocarcinogenesis. As a transactivator, HBx can affect regulatory non-coding RNAs (ncRNAs), including microRNAs and long ncRNAs. HBx is also involved in epigenetic modification and DNA repair. HBx interacts with various signal-transduction pathways, such as the p53, Wnt, and nuclear factor-κB pathways. We conclude that HBx hastens the development of hepatoma.
authors.affiliation: Ming Geng, Xuan Xin, Li-Quan Bi, Lu-Ting Zhou, Xiao-Hong Liu, Department of Pathology, General Hospital of Jinan Military Command, Jinan 250031, Shandong Province, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Geng
authors.affiliation: Ming Geng, Xuan Xin, Li-Quan Bi, Lu-Ting Zhou, Xiao-Hong Liu, Department of Pathology, General Hospital of Jinan Military Command, Jinan 250031, Shandong Province, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xin
authors.affiliation: Ming Geng, Xuan Xin, Li-Quan Bi, Lu-Ting Zhou, Xiao-Hong Liu, Department of Pathology, General Hospital of Jinan Military Command, Jinan 250031, Shandong Province, China.
authors.forename: Li-Quan
authors.initials: LQ
authors.lastname: Bi
authors.affiliation: Ming Geng, Xuan Xin, Li-Quan Bi, Lu-Ting Zhou, Xiao-Hong Liu, Department of Pathology, General Hospital of Jinan Military Command, Jinan 250031, Shandong Province, China.
authors.forename: Lu-Ting
authors.initials: LT
authors.lastname: Zhou
authors.affiliation: Ming Geng, Xuan Xin, Li-Quan Bi, Lu-Ting Zhou, Xiao-Hong Liu, Department of Pathology, General Hospital of Jinan Military Command, Jinan 250031, Shandong Province, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Liu
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000821:virology; D002465:Cell Movement; D049109:Cell Proliferation; D019175:DNA Methylation; D004260:DNA Repair; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000821:virology; D035683:MicroRNAs / Q000235:genetics; D022661:RNA, Untranslated / Q000235:genetics; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism*; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein
keywords: Hepatitis B virus; Hepatitis B virus X protein; Hepatocarcinogenesis; Hepatocellular carcinoma