title: Phaseolus vulgaris lectins: A systematic review of characteristics and health implications.
abstract: Legume lectins are carbohydrate-binding proteins of non-immune origin. Significant amounts of lectins have been found in Phaseolus vulgaris beans as far back as in the last century; however, many questions about their potential biological roles still remain obscure. Studies have shown that lectins are anti-nutritional factors that can cause intestinal disorders. Owing to their ability to act as toxic allergens and hemagglutinins, the Phaseolus vulgaris lectins are of grave concern for human health and safety. Nonetheless, their potential beneficial health effects, such as anti-cancer, anti-human immunodeficiency virus (anti-HIV), anti-microbial infection, preventing mucosal atrophy, reducing type 2 diabetes and obesity, promoting nutrients absorption and targeting drugs, are of immense interest. The significance of Phaseolus vulgaris lectins in biological researches and the potential biomedical applications have placed tremendous emphasis on the development of purification strategies to obtain the protein in pure and stable forms. These purification strategies entail considerations such as effects of proteolysis, heating, gamma radiation, and high-hydrostatic-pressure that can have crucial outcomes in either eliminating or improving bioactivities of the lectins. Thus, up-to-date research findings of Phaseolus vulgaris lectins on different aspects such as anti-nutritional and health impacts, purification strategies and novel processing trends, are systematically reviewed.
authors.affiliation: a School of Biotechnology and Food Engineering , Hefei University of Technology , Hefei , Anhui , China.|b School of Food Science and Engineering , Harbin Institute of Technology , Harbin , Heilongjiang , China.|c Department of Food Science and Agricultural Chemistry , Macdonald Campus, McGill University , Ste-Anne-de-Bellevue, Québec , Canada.
authors.forename: Shudong
authors.initials: S
authors.lastname: He
authors.affiliation: c Department of Food Science and Agricultural Chemistry , Macdonald Campus, McGill University , Ste-Anne-de-Bellevue, Québec , Canada.
authors.forename: Benjamin K
authors.initials: BK
authors.lastname: Simpson
authors.affiliation: a School of Biotechnology and Food Engineering , Hefei University of Technology , Hefei , Anhui , China.
authors.forename: Hanju
authors.initials: H
authors.lastname: Sun
authors.affiliation: d Department of Bioresource Engineering , Macdonald Campus, McGill University , Ste-Anne-de-Bellevue, Québec , Canada.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Ngadi
authors.affiliation: b School of Food Science and Engineering , Harbin Institute of Technology , Harbin , Heilongjiang , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.affiliation: e Advanced Electrophoresis Solutions Ltd. , Cambridge , Ontario , Canada.
authors.forename: Tiemin
authors.initials: T
authors.lastname: Huang
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D016588:Anticarcinogenic Agents; D004032:Diet; D004063:Digestion; D004355:Drug Stability; D005260:Female; D005511:Food Handling / Q000379:methods; D006293:Health Promotion; D006801:Humans; D007109:Immunity; D007410:Intestinal Diseases / Q000139:chemically induced; D008297:Male; D010835:Phytohemagglutinins / Q000008:administration & dosage* / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D016588:Anticarcinogenic Agents; D010835:Phytohemagglutinins
keywords: Lectin; Phaseolus vulgaris bean; beneficial and detrimental properties; processing; purification strategy