title: The role of Eph/ephrin molecules in stromal–hematopoietic  interactions.
abstract: Bone marrow mesenchymal stromal/stem cells(BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrinligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrintargeted therapeutic strategies that are currently being pursued or various hematotological malignancies.
authors.forename: Thao M
authors.initials: TM
authors.lastname: Nguyen
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Arthur
authors.forename: Stan
authors.initials: S
authors.lastname: Gronthos
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000235:genetics; D036342:Ephrins / Q000378:metabolism / Q000502:physiology*; D019337:Hematologic Neoplasms / Q000628:therapy; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008024:Ligands; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D058990:Molecular Targeted Therapy; D036082:Receptor, EphA1 / Q000378:metabolism / Q000502:physiology*
chemical_list: D036342:Ephrins; D008024:Ligands; D036082:Receptor, EphA1