title: Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines.
abstract: The diterpenoid alkaloids as one type of heterocyclic alkaloids have been found in many traditional herbal medicines, such as genus Consolida, Aconitum, and Delphinium (Ranunculaceae). Pharmacological researches have indicated that many diterpenoid alkaloids are the main bioactive components which have analgesic, anti-inflammatory, anti-microbial, anti-tumor, cardiotonic, and anti-arrhythmic activities. Studies focused on the determination, quantitation and pharmacological properties of these alkaloids have dramatically increased during the past few years. Up to now, newly discovered diterpenoid alkaloids with important biological activities have been isolated and synthesized. Considering their significant role and diffusely used in many disease treatments, we summarized the information of their analysis methods, bioactivity, metabolism and biotransformation in vivo as well as the pharmacological mechanisms. Based on above review, the further researches are suggested.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, National Center for Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of the Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Tengfei
authors.initials: T
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, National Center for Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Liu
authors.affiliation: Jilin Provincial Science & Technology Department, Changchun 130041, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Meng
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, National Center for Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: mslab21@ciac.ac.cn.
authors.forename: Zifeng
authors.initials: Z
authors.lastname: Pi
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, National Center for Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Fengrui
authors.initials: F
authors.lastname: Song
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, National Center for Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: liuzq@ciac.ac.cn.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D006571:Heterocyclic Compounds
keywords: Analysis methods; Biological activity; Biotransformation; Diterpendoid alkaloids; Metabolism