title: [A Case of Ascending Colon Cancer Showing Marked Reduction of Ascites by Bevacizumab Combination Chemotherapy].
abstract: A 68-year-old woman presented to our hospital with abdominal fullness. Computed tomography(CT)revealed ascites and massive tumors in the abdominal cavity. She was diagnosed with ascending colon cancer with peritoneal dissemination and ovarian metastasis. After ileostomy, panitumumab plus mFOLFOX6 therapy was initiated, but it was discontinued due to adverse events. As the ascites rapidly increased, her chemotherapy was changed to bevacizumab(BV)plus FOLFIRI. BV combination therapy resulted in a dramatic decrease in ascites and improved her quality of life, whereas the therapy did not reduce the primary and metastatic lesions. Our case suggested that BV could decrease ascites by inhibiting vascular endothelial growth factor(VEGF)-induced vascular permeability.
authors.affiliation: Dept. of Oncology, Shinko Hospital.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kusama
authors.forename: Akihiro
authors.initials: A
authors.lastname: Higashida
authors.forename: Takashi
authors.initials: T
authors.lastname: Komatsubara
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nishigori
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Kokado
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ishii
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001201:Ascites / Q000209:etiology*; D000068258:Bevacizumab; D044682:Colon, Ascending / Q000473:pathology*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000556:secondary; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab