title: Structural Studies of G Protein-Coupled Receptors.
abstract: G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions.
authors.affiliation: CAS Key Laboratory of Receptor Research, Shanghai Institute of Mate-ria Medica, Chinese Academy of Sciences, Pudong, Shanghai 201203, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: CAS Key Laboratory of Receptor Research, Shanghai Institute of Mate-ria Medica, Chinese Academy of Sciences, Pudong, Shanghai 201203, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: CAS Key Laboratory of Receptor Research, Shanghai Institute of Mate-ria Medica, Chinese Academy of Sciences, Pudong, Shanghai 201203, China.
authors.forename: Beili
authors.initials: B
authors.lastname: Wu
mesh_terms: D000494:Allosteric Regulation; D020816:Amino Acid Motifs; D006801:Humans; D008024:Ligands; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000145:classification / Q000502:physiology*
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled
keywords: GPCR; activation; allosteric modulation; ligand recognition; structure