title: IL-10 Gene Polymorphisms Are Associated with Post-Bronchiolitis Lung Function Abnormalities at Six Years of Age.
abstract: OBJECTIVE
  Interleukin-10 (IL-10) has been associated with wheezing and asthma in children and the genetic variation of the IL-10 cytokine production may be linked to post-bronchiolitis lung function. We used impulse oscillometry (IOS) to evaluate the associations of IL10 polymorphisms with lung function at a median age of 6.3 years in children hospitalised for bronchiolitis before six months of age.
  
  
  METHODS
  We performed baseline and post-exercise IOS on 103 former bronchiolitis patients. Data on single nucleotide polymorphisms (SNP) of IL10 rs1800896 (-1082G/A), rs1800871 (-819C/T), rs1800872 (-592C/A) were available for 99 children and of IL10 rs1800890 (-3575T/A) for 98 children.
  
  
  RESULTS
  IL10 rs1800896, rs1800871 and rs1800872 combined genotype AA+CT+CA and carriage of haplotype ATA, respectively, were associated with higher resistance and lower reactance in baseline IOS in adjusted analyses. At IL10 rs1800890, the A/A-genotype and carriers of A-allele were associated with lower reactance in baseline IOS. There were no significant associations between the studied SNPs and airway hyper-reactivity to exercise.
  
  
  CONCLUSIONS
  Low-IL-10-producing polymorphisms in the IL-10 encoding gene were associated with obstructive lung function parameters, suggesting an important role for IL-10 in development of lung function deficit in early bronchiolitis patients.
authors.affiliation: Tampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Lauhkonen
authors.affiliation: Tampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors.forename: Petri
authors.initials: P
authors.lastname: Koponen
authors.affiliation: Department of Medical Microbiology and Immunology, Turku University, Turku, Finland; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Teräsjärvi
authors.affiliation: Department of Medical Microbiology and Immunology, Turku University, Turku, Finland; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
authors.forename: Kirsi
authors.initials: K
authors.lastname: Gröndahl-Yli-Hannuksela
authors.affiliation: Department of Medical Microbiology and Immunology, Turku University, Turku, Finland; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
authors.forename: Juho
authors.initials: J
authors.lastname: Vuononvirta
authors.affiliation: Seinäjoki Central Hospital, Seinäjoki, Finland.
authors.forename: Kirsi
authors.initials: K
authors.lastname: Nuolivirta
authors.affiliation: Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Turku University Hospital, Turku, Finland.
authors.forename: Jyri O
authors.initials: JO
authors.lastname: Toikka
authors.affiliation: Tampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors.forename: Merja
authors.initials: M
authors.lastname: Helminen
authors.affiliation: Department of Medical Microbiology and Immunology, Turku University, Turku, Finland; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
authors.forename: Qiushui
authors.initials: Q
authors.lastname: He
authors.affiliation: Tampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Korppi
mesh_terms: D001988:Bronchiolitis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics* / Q000378:metabolism; D008168:Lung / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012129:Respiratory Function Tests
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10