title: IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection.
abstract: Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL-4 produced by PLZF+ innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8+ T cells are critical for accelerating the control of chronic virus infection. In CIITA-transgenic mice, which have a substantial population of IL-4-induced innate CD8+ T cells, this population facilitated rapid control of viremia and induction of functional anti-viral T-cell responses during infection with chronic form of lymphocytic choriomeningitis virus. Characteristically, anti-viral innate CD8+ T cells accumulated sufficiently during early phase of infection. They produced a robust amount of IFN-γ and TNF-α with enhanced expression of a degranulation marker. Furthermore, this finding was confirmed in wild-type mice. Taken together, the results from our study show that innate CD8+ T cells works as an early defense mechanism against chronic viral infection.
authors.affiliation: Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea.
authors.forename: Ara
authors.initials: A
authors.lastname: Lee
authors.affiliation: Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Seung Pyo
authors.initials: SP
authors.lastname: Park
authors.affiliation: Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea.
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Park
authors.affiliation: Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Byung Hyun
authors.initials: BH
authors.lastname: Kang
authors.affiliation: Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Seong Hoe
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, Korea.
authors.forename: Sang-Jun
authors.initials: SJ
authors.lastname: Ha
authors.affiliation: Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Kyeong Cheon
authors.initials: KC
authors.lastname: Jung
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002469:Cell Separation; D002908:Chronic Disease; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D007113:Immunity, Innate / Q000276:immunology*; D016130:Immunophenotyping; D015847:Interleukin-4 / Q000276:immunology*; D008216:Lymphocytic Choriomeningitis / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D015847:Interleukin-4