title: Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells.
abstract: In order to enhance the interactions between macrophages and cancer cells, thiol-terminated nucleic acid aptamers were immobilized on methacryloyl-functionalised carbohydrates of macrophages. The adhesion of cancer cells on the surface modified macrophages was significantly accelerated.
authors.affiliation: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan. yasu.bmt@kansai-u.ac.jp.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Sugimoto
authors.affiliation: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan. yasu.bmt@kansai-u.ac.jp and Department of Applied Chemistry, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka 804-0015, Japan.
authors.forename: Rui
authors.initials: R
authors.lastname: Moriyama
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.affiliation: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan. yasu.bmt@kansai-u.ac.jp.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Iwasaki
mesh_terms: D000606:Amino Sugars / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000528:radiation effects; D002448:Cell Adhesion; D060846:Cell Engineering; D045744:Cell Line, Tumor; D003584:Cytological Techniques; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D061925:Immobilized Nucleic Acids / Q000737:chemistry / Q000528:radiation effects; D008027:Light; D008214:Lymphocytes / Q000473:pathology*; D008264:Macrophages / Q000737:chemistry* / Q000502:physiology; D051379:Mice; D019158:N-Acetylneuraminic Acid / Q000737:chemistry; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D013499:Surface Properties
chemical_list: D000606:Amino Sugars; D052157:Aptamers, Nucleotide; D005456:Fluorescent Dyes; D061925:Immobilized Nucleic Acids; C000610074:N-methacryloyl mannosamine; C486452:Ptk7 protein, mouse; D020794:Receptor Protein-Tyrosine Kinases; D019158:N-Acetylneuraminic Acid