title: Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328.
abstract: Six new compounds with polyketide decalin ring, peaurantiogriseols A-F (1-6), along with two known compounds, aspermytin A (7), 1-propanone,3-hydroxy-1- (1,2,4a,5,6,7,8,8a-octahydro-2,5-dihydroxy-1,2,6-trimethyl-1-naphthalenyl) (8), were isolated from the fermentation products of mangrove endophytic fungus Penicillium aurantiogriseum 328#. Their structures were elucidated based on their structure analysis. The absolute configurations of compounds 1 and 2 were determined by ¹H NMR analysis of their Mosher esters; the absolute configurations of 3-6 were determined by using theoretical calculations of electronic circular dichroism (ECD). Compounds 1-8 showed low inhibitory activity against human aldose reductase, no activity of inducing neurite outgrowth, nor antimicrobial activity.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. mayh6@mail2.sysu.edu.cn.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. lijing356@mail.sysu.edu.cn.|Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080, China. lijing356@mail.sysu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. huangmx7@mail2.sysu.edu.cn.
authors.forename: Meixiang
authors.initials: M
authors.lastname: Huang
authors.affiliation: School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. cesllan@mail.sysu.edu.cn.|South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. cesllan@mail.sysu.edu.cn.
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. wjun@mail.sysu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080, China. ceslyc@mail.sysu.edu.cn.|South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. ceslyc@mail.sysu.edu.cn.|School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. ceslyc@mail.sysu.edu.cn.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D002942:Circular Dichroism; D060026:Endophytes; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010407:Penicillium / Q000378:metabolism*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D064210:Secondary Metabolism
chemical_list: D004791:Enzyme Inhibitors; D009281:Naphthalenes; D061065:Polyketides; C007229:decalin; D000449:Aldehyde Reductase
keywords: Penicillium aurantiogriseum; mangrove endophytic fungi; polyketide decalin derivative; secondary metabolites