title: Resveratrol, sirtuins, and viruses.
abstract: Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. Over the past several decades, a great deal of research has identified diverse biological roles associated with resveratrol, including anti-oxidant, anti-proliferation, anti-inflammation, anti-cancer, anti-fungal, and antiviral activities. Such biological activities of resveratrol are likely mediated through multiple cellular targets or pathways, such as sirtuins, a family of NAD(+)-dependent deacetylases. In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. A working model about the effects of resveratrol on virus infection is proposed to stimulate further researches on this exciting topic.
authors.affiliation: College of Food Science and Technology, Central South University of Forestry and Technology, Changsha, Hunan Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Construction Corps Key Laboratory of Deep Processing on Featured Agricultural Products in South Xinjiang, Tarim University, Alar, Xinjiang, China.
authors.forename: Shugang
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Xuming
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Departments of Oral Pathology, College of Dentistry, Howard University, Washington, DC, USA.
authors.forename: Xiaowu
authors.initials: X
authors.lastname: Pang
authors.affiliation: College of Food Science and Technology, Central South University of Forestry and Technology, Changsha, Hunan Province, China.
authors.forename: Qinlu
authors.initials: Q
authors.lastname: Lin
authors.affiliation: College of Food Science and Technology, Central South University of Forestry and Technology, Changsha, Hunan Province, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Cao
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism*; D001688:Biological Products / Q000378:metabolism*; D006801:Humans; D000077185:Resveratrol; D037761:Sirtuins / Q000378:metabolism*; D013267:Stilbenes / Q000378:metabolism*; D014780:Viruses / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D001688:Biological Products; D013267:Stilbenes; D037761:Sirtuins; D000077185:Resveratrol