title: Lipoprotein (a) is a risk factor for coronary artery disease in Chinese Han ethnic population modified by some traditional risk factors: A cross-sectional study of 3462 cases and 6125 controls.
abstract: BACKGROUND
  Lipoprotein (a) (Lp (a)) is a well-established risk factor for coronary artery disease (CAD) in Caucasians. However, data regarding the association of Lp (a) with CAD are lacking in Chinese Han population.
  
  
  METHODS
  Cross-sectional study of 3462 cases and 6125 controls was performed for identifying the association of Lp (a) with CAD and its possible interactions with risk factors on CAD in Chinese.
  
  
  RESULTS
  The Lp (a) levels in Chinese Han population were on average much lower than those in Caucasians. The suggested Lp (a) cutoff for discriminating CAD from non-CAD was 78.9 mg/dl. On a continuous or categorical scale, the odds ratios for CAD were almost consistently and significantly stepwise increased with the increased Lp (a) levels or quintiles in both genders. Significant interactions were found between Lp (a) and primary hypertension, body mass index, total cholesterol, and creatinin on CAD subdivisions.
  
  
  CONCLUSIONS
  The Lp (a) distribution in Chinese Han population differs from that in Caucasian populations. The higher Lp (a) level is a confirmative risk factor for CAD, which can be modified by some risk factors in Chinese Han population. Our study provides direct evidence for differential approach to higher Lp (a) levels in Chinese.
authors.affiliation: Division of Cardiology, The First Affiliated Hospital of Soochow University, PR China.
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Cai
authors.affiliation: Division of Cardiology, The First Affiliated Hospital of Soochow University, PR China. Electronic address: heyongming@suda.edu.cn.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: He
authors.affiliation: Division of Cardiology, The First Affiliated Hospital of Soochow University, PR China.
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Division of Cardiology, The First Affiliated Hospital of Soochow University, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Division of Cardiology, The First Affiliated Hospital of Soochow University, PR China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Xu
mesh_terms: D000368:Aged; D044466:Asian People; D002681:China; D003324:Coronary Artery Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D044465:White People
chemical_list: D017270:Lipoprotein(a)
keywords: Chinese Han ethnic population; Coronary artery disease; Cross-sectional study; Lipoprotein (a); Odds ratio