title: [Correlation Between Serological Indices and Liver Histological Pathology in Patients with HBV Infection].
abstract: OBJECTIVE
  To analyze the correlation between serological indices and liver histological pathology in the patients with hepatitis B virus ( HBV) infection.
  
  
  METHODS
  This study enrolled 301 patients with HBV infection. All of them received liver biopsy, serum biochemical examination, including alanineamino transferase (ALT), aspart ateaminotransferase (AST), albumin (ALB), globulin (GLB ), HBV DNA test and HBV genotype detection.
  
  
  RESULTS
  ALT, AST and AST/ALT in G2/G(3+4) group were significantly higher than those in group G0/G1 (P < 0.05), and all showed positive correlation with liver inflammation (r = 0.487, 0.648, 0.509, P < 0.05). GLB in S2/S(3+4) group was significantly higher than that in group S0/S1 (P < 0.05), which had positive correlation with liver fibrosis (r = 0.674, P < 0.05). ALB/GLB (A/G) in S2/S(3+4) group was significantly lower than that in group S0/S1 (P < 0.05), it had negative correlation with liver fibrosis(r = -0.500, P < 0.05). The inflammation and fibrosis level in patients with C genotype was higher than that of B genotype (χ2 = 11.460, 12.729, P < 0.05).
  
  
  CONCLUSIONS
  ALT, AST and AST/ALT show better diagnostic value in liver inflammation. GLB and A/G show better diagnostic value in liver fibrosis. The progress of this disease is relatively faster in the patients with C genotype HBV infection.
authors.forename: Li-yu
authors.initials: LY
authors.lastname: Chen
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Wei-ya
authors.initials: WY
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
authors.forename: Ping
authors.initials: P
authors.lastname: Feng
mesh_terms: D004279:DNA, Viral / Q000097:blood; D005838:Genotype; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology
chemical_list: D004279:DNA, Viral; D006513:Hepatitis B e Antigens