title: Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection.
abstract: Dysregulation of microRNA-21 (miR-21) is independently associated with HIV infection, pulmonary arterial hypertension (PAH), and hepatitis C virus (HCV) infection. To assess the expression of miR-21 in these overlapping comorbidities, we measured plasma miR-21 in HIV with and without PAH and then stratified by concomitant HCV infection. MiR-21 was increased in HIV and HIV-PAH versus uninfected subjects, but it did not differ between these groups. HIV/HCV coinfection correlated with even higher miR-21 levels within the HIV-infected population. These data reveal specific regulation of plasma miR-21 in HIV, HIV/HCV coinfection, and PAH and suggest that miR-21 may integrate complex disease-specific signaling in the setting of HIV infection.
authors.affiliation: *Division of Cardiology and Center of Excellence in Vascular Research, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA; †Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ‡Divisions of Pulmonology and Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and §Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Victoria N
authors.initials: VN
authors.lastname: Parikh
authors.forename: Joseph
authors.initials: J
authors.lastname: Park
authors.forename: Ivana
authors.initials: I
authors.lastname: Nikolic
authors.forename: Richard
authors.initials: R
authors.lastname: Channick
authors.forename: Paul B
authors.initials: PB
authors.lastname: Yu
authors.forename: Teresa
authors.initials: T
authors.lastname: De Marco
authors.forename: Priscilla Y
authors.initials: PY
authors.lastname: Hsue
authors.forename: Stephen Y
authors.initials: SY
authors.lastname: Chan
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D008297:Male; D035683:MicroRNAs / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged
chemical_list: C524940:MIRN21 microRNA, human; D035683:MicroRNAs