title: Cutaneous Adverse Drug Reactions with Antimalarials and Allergological Skin Tests.
abstract: BACKGROUND
  Currently used antimalarial drugs (AM) are hydroxychloroquine and chloroquine, which are prescribed for many autoimmune disorders. The value of skin tests on cutaneous adverse drug reactions (CADR) with AM remains unknown.
  
  
  OBJECTIVE
  The main objective of this retrospective study is to know whether skin tests for AM are useful and how to manage the recovery of AM therapy in these patients.
  
  
  METHODS
  All patients referred for suspected CADR secondary to AM between 2001 and 2014 in eight French dermatology centers were retrospectively reviewed.
  
  
  RESULTS
  We report herein a retrospective series of 20 patients with CADR and AM involvement. Skin tests, performed in 14/20 patients, were negative in all cases. Six patients had an oral provocation test with recurrence of CADR in 1 case.
  
  
  CONCLUSIONS
  We encourage dermatologists to perform oral provocation tests in nonsevere CADR in order to allow AM rechallenge at progressive doses.
authors.affiliation: Department of Dermatology and Allergology, Hx00F4;pital Tenon, Assistance Publique Hx00F4;pitaux de Paris, AP-HP, Sorbonne Universitx00E9;s, Paris, France.
authors.forename: Angèle
authors.initials: A
authors.lastname: Soria
authors.forename: Annick
authors.initials: A
authors.lastname: Barbaud
authors.forename: Haudrey
authors.initials: H
authors.lastname: Assier
authors.forename: Martine
authors.initials: M
authors.lastname: Avenel-Audran
authors.forename: Florence
authors.initials: F
authors.lastname: Tétart
authors.forename: Nadia
authors.initials: N
authors.lastname: Raison-Peyron
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Amarger
authors.forename: Pascal
authors.initials: P
authors.lastname: Girardin
authors.forename: Camille
authors.initials: C
authors.lastname: Francès
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000009:adverse effects*; D002648:Child; D002738:Chloroquine / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012882:Skin Tests; D055815:Young Adult
chemical_list: D000962:Antimalarials; D006886:Hydroxychloroquine; D002738:Chloroquine