title: Developments in coupled solid-phase extraction-capillary electrophoresis 2013-2015.
abstract: An overview of the design and application of coupled solid-phase extraction-capillary electrophoresis (SPE-CE) systems reported in the literature between July 2013 and June 2015 is provided in this paper. The present article is a continuation of our previous review papers on this topic which covered the time period 2000-2013 (Electrophoresis 2008, 29, 108-128; Electrophoresis 2010, 31, 44-54; Electrophoresis 2012, 33, 243-250; Electrophoresis 2014, 35, 128-137). The use of in-line and on-line SPE-CE approaches is treated and outlined in this review. Recent advancements, such as, for example, the use of aptamers as affinity material for in-line SPE-CE, the use of a bead string design for in-line fritless SPE-CE, and new interfacing techniques for the on-line coupling of SPE to CE, are outlined. Selected examples demonstrate the applicability of the coupled SPE-CE systems for biomedical, pharmaceutical, environmental, and food studies. A complete overview of the recent SPE-CE studies is given in table format, providing information on sample type, SPE sorbent, coupling mode, detection mode, and LOD. Finally, some general conclusions and perspectives are provided.
authors.affiliation: Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
authors.forename: Rawi
authors.initials: R
authors.lastname: Ramautar
authors.affiliation: AIMMS Division of BioAnalytical Chemistry, VU University Amsterdam, Amsterdam, The Netherlands.
authors.forename: Govert W
authors.initials: GW
authors.lastname: Somsen
authors.affiliation: Biomolecular Analysis, Utrecht University, Utrecht, The Netherlands.
authors.forename: Gerhardus J
authors.initials: GJ
authors.lastname: de Jong
mesh_terms: D019075:Electrophoresis, Capillary; D052616:Solid Phase Extraction
keywords: Biomedical and pharmaceutical applications; Environmental and food applications; In-line SPE-CE; Monoliths; On-line SPE-CE