title: Angiotensin-converting enzyme inhibitor-induced angioedema and hereditary angioedema: a comparison study of attack severity.
abstract: Objective There appears to be differences in the clinical presentation of hereditary angioedema (HAE) and angiotensin-converting enzyme inhibitor-induced (ACE-I) angioedema (AE). The aim of this study was to compare the clinical characteristics of these two AE forms. Methods We conducted a retrospective study of consecutive patients with HAE or ACE-I AE. The attack characteristics experienced by the patients were compared by a logistic regression analysis using generalized estimating equations. Results A total of 56 patients were included in this study (ACE-I AE, n=25; HAE, n=31). A total of 534 attacks were documented. Severe attacks were more common in the patients who had an acute episode of ACE-I AE than HAE. Swelling of the tongue, lips and larynx were significantly associated with ACE-I AE [OR: 8.70 (95% CI, 1.04-73.70), OR: 20.4 (95% CI, 4.9-84.2) and OR: 7.50 (95% CI, 1.20-48.30), respectively]. Conclusion Swelling of the tongue, lips and larynx are significantly more frequent in drug-induced AE than HAE.
authors.affiliation: Emergency Department, Angioedema Reference Center (CRéAk), Public Assistance Hospital of Paris, University Hospital of Jean Verdier, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Javaud
authors.forename: Stéphane
authors.initials: S
authors.lastname: Charpentier
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lapostolle
authors.forename: Hakim
authors.initials: H
authors.lastname: Lekouara
authors.forename: Marouane
authors.initials: M
authors.lastname: Boubaya
authors.forename: Gilles
authors.initials: G
authors.lastname: Lenoir
authors.forename: Arsène
authors.initials: A
authors.lastname: Mekinian
authors.forename: Frédéric
authors.initials: F
authors.lastname: Adnet
authors.forename: Olivier
authors.initials: O
authors.lastname: Fain
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000799:Angioedema / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology*; D054179:Angioedemas, Hereditary / Q000175:diagnosis / Q000473:pathology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007830:Larynx / Q000187:drug effects / Q000473:pathology*; D008046:Lip / Q000187:drug effects / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014059:Tongue / Q000187:drug effects / Q000473:pathology*; D055815:Young Adult
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007166:Immunosuppressive Agents