title: Stereospecific S(N)2@P reactions: novel access to bulky P-stereogenic ligands.
abstract: The stereospecific hydrolysis of bulky aminophosphine boranes is reported for the first time. The resulting phosphinous acid boranes, upon activation, undergo stereospecific nucleophilic substitution reaction at the phosphorous center with amine nucleophiles. The combination of these two processes provides a novel access to bulky P*-ligands.
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, E-08028, Spain. antoni.riera@irbbarcelona.org xavier.verdaguer@irbbarcelona.org.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Orgué
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, E-08028, Spain. antoni.riera@irbbarcelona.org xavier.verdaguer@irbbarcelona.org.
authors.forename: Areli
authors.initials: A
authors.lastname: Flores-Gaspar
authors.affiliation: Department Química Física i Inorgànica, Universitat Rovira i Virgili, Marcel lí Domingo s/n, 43007 Tarragona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Biosca
authors.affiliation: Department Química Física i Inorgànica, Universitat Rovira i Virgili, Marcel lí Domingo s/n, 43007 Tarragona, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Pàmies
authors.affiliation: Department Química Física i Inorgànica, Universitat Rovira i Virgili, Marcel lí Domingo s/n, 43007 Tarragona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Diéguez
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, E-08028, Spain. antoni.riera@irbbarcelona.org xavier.verdaguer@irbbarcelona.org and Department de Química Orgànica, Universitat de Barcelona, Martí i Franquès 1, E-08028 Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Riera
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, E-08028, Spain. antoni.riera@irbbarcelona.org xavier.verdaguer@irbbarcelona.org and Department de Química Orgànica, Universitat de Barcelona, Martí i Franquès 1, E-08028 Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Verdaguer