title: Functional promoter polymorphisms of the receptor for advanced glycation end products in children and adolescents with type 1 diabetes.
abstract: RAGE promoter polymorphisms are associated with increases in RAGE expression. A case-control association study was conducted involving a Euro-Brazilian population of children and adolescents with type 1 diabetes (n = 90) and healthy controls (n = 105), which were matched by sex and age. Genotyping by PCR-RFLP the -429T>C (rs1800625), -374T>A (rs1800624), and 63 bp deletion/insertion (-407 to -345 bp) showed no significant differences (P > 0.05) between the groups.
authors.affiliation: Department of Clinical Analysis, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Letícia Carneiro
authors.initials: LC
authors.lastname: Gomes
authors.affiliation: Department of Clinical Analysis, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Marciane
authors.initials: M
authors.lastname: Welter
authors.affiliation: Department of Clinical Analysis, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Luiza Cristina
authors.initials: LC
authors.lastname: Gobor
authors.affiliation: Department of Bioinformatics, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Izabella Castilhos Ribeiro
authors.initials: ICR
authors.lastname: Santos-Weiss
authors.affiliation: Pediatric Endocrinology Unit, Department of Pediatrics, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Suzana Nesi
authors.initials: SN
authors.lastname: França
authors.affiliation: Department of Clinical Analysis, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Dayane
authors.initials: D
authors.lastname: Alberton
authors.affiliation: Department of Clinical Analysis, Federal University of Parana, Curitiba, Parana, Brazil.
authors.forename: Geraldo
authors.initials: G
authors.lastname: Picheth
authors.affiliation: Department of Clinical Analysis, Federal University of Parana, Curitiba, Parana, Brazil. Electronic address: rego@ufpr.br.
authors.forename: Fabiane Gomes
authors.initials: FG
authors.lastname: Rego
mesh_terms: D000293:Adolescent; D001938:Brazil; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005060:Europe; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D005838:Genotype; D060005:Genotyping Techniques / Q000379:methods; D006801:Humans; D007223:Infant; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics*
chemical_list: D000067759:Receptor for Advanced Glycation End Products
keywords: Genetic variability; RAGE gene; Single nucleotide polymorphism; Type 1 diabetes