title: Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.
abstract: The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous +Mat/CLPGPat animals receiving the CLPG mutation from their father express the phenotype. +Mat/CLPGPat animals are characterized by postnatal, ectopic expression of Delta-like 1 homologue (DLK1) and Paternally expressed gene 11/Retrotransposon-like 1 (PEG11/RTL1) proteins in skeletal muscle. We showed previously in transgenic mice that ectopic expression of DLK1 alone induces a muscular hypertrophy, hence demonstrating a role for DLK1 in determining the callipyge hypertrophy. We herein describe newly generated transgenic mice that ectopically express PEG11 in skeletal muscle, and show that they also exhibit a muscular hypertrophy phenotype. Our data suggest that both DLK1 and PEG11 act together in causing the muscular hypertrophy of callipyge sheep.
authors.affiliation: Unit of Animal Genomics, GIGA Research Center and Faculty of Veterinary Medicine, University of Liège, 1 Avenue de l'Hôpital, Liège, Belgium.
authors.forename: Xuewen
authors.initials: X
authors.lastname: Xu
authors.affiliation: Transgenic platform, FARAH and GIGA Research Center, University of Liège, 1 Avenue de l'Hôpital, Liège, Belgium.
authors.forename: Fabien
authors.initials: F
authors.lastname: Ectors
authors.affiliation: Unit of Animal Genomics, GIGA Research Center and Faculty of Veterinary Medicine, University of Liège, 1 Avenue de l'Hôpital, Liège, Belgium.
authors.forename: Erica E
authors.initials: EE
authors.lastname: Davis
authors.affiliation: Unit of Animal Genomics, GIGA Research Center and Faculty of Veterinary Medicine, University of Liège, 1 Avenue de l'Hôpital, Liège, Belgium.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Pirottin
authors.affiliation: Unit of Animal Genomics, GIGA Research Center and Faculty of Veterinary Medicine, University of Liège, 1 Avenue de l'Hôpital, Liège, Belgium.
authors.forename: Huijun
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Unit of Biostatistics, FARAH and Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster, Liège, Belgium.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Farnir
authors.affiliation: Department of Animal, Dairy and Veterinary sciences, Utah State University, Logan, Utah, United States of America.
authors.forename: Tracy
authors.initials: T
authors.lastname: Hadfield
authors.affiliation: Department of Animal, Dairy and Veterinary sciences, Utah State University, Logan, Utah, United States of America.
authors.forename: Noelle
authors.initials: N
authors.lastname: Cockett
authors.affiliation: Unit of Animal Genomics, GIGA Research Center and Faculty of Veterinary Medicine, University of Liège, 1 Avenue de l'Hôpital, Liège, Belgium.
authors.forename: Carole
authors.initials: C
authors.lastname: Charlier
authors.affiliation: Unit of Animal Genomics, GIGA Research Center and Faculty of Veterinary Medicine, University of Liège, 1 Avenue de l'Hôpital, Liège, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: Georges
authors.affiliation: Unit of Animal Genomics, GIGA Research Center and Faculty of Veterinary Medicine, University of Liège, 1 Avenue de l'Hôpital, Liège, Belgium.
authors.forename: Haruko
authors.initials: H
authors.lastname: Takeda
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D020966:Muscular Disorders, Atrophic / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D009154:Mutation; D011257:Pregnancy Proteins / Q000235:genetics*; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics* / Q000473:pathology
chemical_list: D008565:Membrane Proteins; D011257:Pregnancy Proteins