title: The tissue dependent interactions between p53 and Bcl-2 in vivo.
abstract: To further investigate the role of p53 in apoptosis in vivo and the interaction between p53 and Bcl-2 in the regulation of cellular apoptosis in vivo, we depleted p53 in Bcl-2-null mice. We found that the interaction between p53 and Bcl-2 are tissue dependent. Specifically, loss of p53 in Bcl-2-/- mice inhibits apoptotic induction in spleen and subsequently inhibits the Bcl-2-null-induced spleen atrophy. Furthermore, p53 deficiency overcomes loss of melanocyte stem cell (MSC)-induced apoptosis and subsequently prevents hair graying in Bcl-2- null mice. In addition, p53 deletion partly inhibits apoptosis in hair follicle keratinocytes, leading to the alleviation of hair growth delay in Bcl-2-null mice. However, p53 absence in Bcl-2-null mice cannot restore other defects in Bcl-2-null mice, including retardation of growth, short ears and polycystic kidney disease.
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China, 200437.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Shanghai University of Traditional Chinese Medicine, Shanghai, China, 201203.
authors.forename: Xiao
authors.initials: X
authors.lastname: Miao
authors.affiliation: Shanghai University of Traditional Chinese Medicine, Shanghai, China, 201203.
authors.forename: Hongshen
authors.initials: H
authors.lastname: Wang
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35233, USA.
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China, 200437.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D017209:Apoptosis; D002478:Cells, Cultured; D006197:Hair / Q000503:physiopathology*; D018859:Hair Follicle / Q000502:physiology*; D008544:Melanocytes / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D058990:Molecular Targeted Therapy; D009928:Organ Specificity; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D013154:Spleen / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53
keywords: Bcl-2; apoptosis; interaction; mice; p53