title: Sleep aspects on video-polysomnography in LRRK2 mutation carriers.
abstract: BACKGROUND
  Rapid eye movement sleep behavior disorder and sleepiness precede or accompany idiopathic Parkinson's disease (PD), but their presence in subjects with leucine-rich repeat kinase 2 mutations is unknown.
  
  
  METHODS
  Ten patients with leucine-rich repeat kinase 2-associated PD, four healthy leucine-rich repeat kinase 2 mutation carriers, 20 patients with idiopathic PD, and 12 healthy controls underwent clinical assessments and a nighttime video-polysomnography.
  
  
  RESULTS
  No sleep changes, no rapid eye movement sleep behavior disorder, or rapid eye movement sleep without atonia was found in the 14 subjects with leucine-rich repeat kinase 2mutations compared with controls, whereas 41% of patients with idiopathic PD had rapid eye movement sleep behavior disorder. Eventually, 20% of patients with leucine-rich repeat kinase 2-associated PD had abnormal periodic leg movements, a frequency similar to the idiopathic PD group frequency.
  
  
  CONCLUSIONS
  The sleep phenotype in leucine-rich repeat kinase 2 mutations parallels that of idiopathic PD, except for absent rapid eye movement sleep behavior disorder here in the presymptomatic and symptomatic stages.
authors.affiliation: Ecole Normale Supérieure, Paris, France.|AP-HP, Hôpital Pitié-Salpêtrière, Sleep Disorders unit and Neurology Department, F-75013, Paris, France.
authors.forename: Mickael
authors.initials: M
authors.lastname: Ehrminger
authors.affiliation: AP-HP, Hôpital Pitié-Salpêtrière, Sleep Disorders unit and Neurology Department, F-75013, Paris, France.|Sorbonne Universitiés, UPMC Univ Paris 06, UMR_S1127, ICM, F-75013, Paris, France.|INSERM, UMR_S1127 and CIC-1422, ICM, F-75013, Paris, France.|CNRS, UMR_7225, ICM, F-75005, Paris, France.
authors.forename: Smaranda
authors.initials: S
authors.lastname: Leu-Semenescu
authors.affiliation: AP-HP, Hôpital Pitié-Salpêtrière, Sleep Disorders unit and Neurology Department, F-75013, Paris, France.|Sorbonne Universitiés, UPMC Univ Paris 06, UMR_S1127, ICM, F-75013, Paris, France.|INSERM, UMR_S1127 and CIC-1422, ICM, F-75013, Paris, France.|CNRS, UMR_7225, ICM, F-75005, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Cormier
authors.affiliation: AP-HP, Hôpital Pitié-Salpêtrière, Sleep Disorders unit and Neurology Department, F-75013, Paris, France.|Sorbonne Universitiés, UPMC Univ Paris 06, UMR_S1127, ICM, F-75013, Paris, France.|INSERM, UMR_S1127 and CIC-1422, ICM, F-75013, Paris, France.|CNRS, UMR_7225, ICM, F-75005, Paris, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Corvol
authors.affiliation: AP-HP, Hôpital Pitié-Salpêtrière, Sleep Disorders unit and Neurology Department, F-75013, Paris, France.|Sorbonne Universitiés, UPMC Univ Paris 06, UMR_S1127, ICM, F-75013, Paris, France.|INSERM, UMR_S1127 and CIC-1422, ICM, F-75013, Paris, France.|CNRS, UMR_7225, ICM, F-75005, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Vidailhet
authors.affiliation: Sorbonne Universitiés, UPMC Univ Paris 06, UMR_S1127, ICM, F-75013, Paris, France.|INSERM, UMR_S1127 and CIC-1422, ICM, F-75013, Paris, France.|CNRS, UMR_7225, ICM, F-75005, Paris, France.
authors.forename: Eden
authors.initials: E
authors.lastname: Debellemaniere
authors.affiliation: AP-HP, Hôpital Pitié-Salpêtrière, Sleep Disorders unit and Neurology Department, F-75013, Paris, France.|Sorbonne Universitiés, UPMC Univ Paris 06, UMR_S1127, ICM, F-75013, Paris, France.|INSERM, UMR_S1127 and CIC-1422, ICM, F-75013, Paris, France.|CNRS, UMR_7225, ICM, F-75005, Paris, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Brice
authors.affiliation: AP-HP, Hôpital Pitié-Salpêtrière, Sleep Disorders unit and Neurology Department, F-75013, Paris, France.|Sorbonne Universitiés, UPMC Univ Paris 06, UMR_S1127, ICM, F-75013, Paris, France.|INSERM, UMR_S1127 and CIC-1422, ICM, F-75013, Paris, France.|CNRS, UMR_7225, ICM, F-75005, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Arnulf
mesh_terms: D000328:Adult; D000368:Aged; D004569:Electroencephalography; D005260:Female; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010300:Parkinson Disease / Q000150:complications* / Q000235:genetics; D017286:Polysomnography; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D014741:Video Recording
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases
keywords: Parkinson's disease; REM sleep behavior disorder; genetic; periodic leg movements; sleepiness