title: Red Cell Distribution Width Can Predict the Significance of Angiographically Intermediate Coronary Lesions.
abstract: OBJECTIVE
  In the present study, the association between red cell distribution width (RDW) with functional significance of intermediate coronary artery lesions was investigated.
  
  
  METHODS
  Two hundred and forty-six consecutive patients, 168 males and 78 females, who underwent fractional flow reserve (FFR) measurement for angiographically intermediate coronary stenosis (40-70% in quantitative coronary analysis) in the left anterior descending coronary artery were enrolled into the study. The functional significance of intermediate coronary artery lesions was determined by FFR measurement. An FFR value <0.75 was defined as functionally significant. Venous blood samples were taken within 48 h before the FFR measurement, and RDW levels were determined by a Coulter LH Series hematology analyzer. Logistic regression analysis was used to examine the association between functional significance in FFR measurement and other variables.
  
  
  RESULTS
  Of the 246 patients, 62 (25.2%) exhibited significant functional stenosis (FFR <0.75) in the FFR measurement. The mean RDW level was significantly higher in patients with significant stenosis (14.19 ± 0.73 vs. 13.69 ± 0.77, p < 0.001). In stepwise multivariate logistic regression analysis, RDW (OR = 2.489, 95% CI = 1.631-3.799, p < 0.001) and male gender (OR = 2.826, 95% CI = 1.347-5.928, p = 0.006) were independent predictors of significant functional stenosis.
  
  
  CONCLUSIONS
  Increased RDW levels were associated with functional significance of angiographically intermediate coronary artery stenoses.
authors.affiliation: Cardiology Clinic, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Sadık Kadri
authors.initials: SK
authors.lastname: Açıkgöz
authors.forename: Burak
authors.initials: B
authors.lastname: Açar
authors.forename: Selahattin
authors.initials: S
authors.lastname: Aydın
authors.forename: Eser
authors.initials: E
authors.lastname: Açıkgöz
authors.forename: Okan
authors.initials: O
authors.lastname: Er
authors.forename: Barış
authors.initials: B
authors.lastname: Şensoy
authors.forename: Mustafa Mücahit
authors.initials: MM
authors.lastname: Balci
authors.forename: Çağrı
authors.initials: Ç
authors.lastname: Yayla
authors.forename: Fatih
authors.initials: F
authors.lastname: Şen
authors.forename: Salih
authors.initials: S
authors.lastname: Topal
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydoğdu
mesh_terms: D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D004909:Erythrocyte Indices; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012737:Sex Factors