title: Structural and Functional Outcomes in Chronic Central Serous Chorioretinopathy Treated with Photodynamic Therapy.
abstract: OBJECTIVE
  To study the retinal pigment epithelium (RPE) and retinal alterations in chronic central serous chorioretinopathy treated with photodynamic therapy, and its correlation with functional parameters such as best-corrected visual acuity (BCVA) and contrast sensitivity (CS).
  
  
  METHODS
  Retrospective, noncomparative, consecutive evaluation by optical coherence tomography and its correlation with BCVA and CS in 31 eyes of 26 patients.
  
  
  RESULTS
  In all affected patients, 88.5% were male with a mean age of 42.9 years. The right eye was involved in 64.5% of cases, bilateral in 19% and 73.9% were hyperopic (spherical refraction between 0 and +5.0 diopters). Of these cases, 51.5% had peri-RPE abnormalities, 17.3% hyperreflective substances at RPE, 19.4% RPE atrophy, 55.3% foveolar atrophy, 3.1% pigment epithelial detachment, 5.2% subretinal fluid persistence, 8.3% fibrin deposits, 68.4% photoreceptor inner and outer segment line interruption and 31.1% external limiting membrane interruption.
  
  
  CONCLUSIONS
  Time evolution and number of outbreaks were related to the decrease in foveal and chorodial thickness and in those with worse BCVA and CS. RPE abnormalities and atrophy were related to the age of onset of symptoms. Photoreceptor elongation has been correlated with poor BCVA and inner and outer segment line destructuring and interruption with poor CS.
authors.affiliation: Ophthalmology Service, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Pino
authors.initials: P
authors.lastname: Cidad
authors.affiliation: Ophthalmology Service, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Eugenia
authors.initials: E
authors.lastname: González
authors.affiliation: Ophthalmology Service, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: Asencio
authors.affiliation: Ophthalmology Service, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: García
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011166:Porphyrins / Q000008:administration & dosage*; D012160:Retina / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins
keywords: Central serous chorioretinopathy; Contrast sensitivity; Optical coherence tomography; Photochemotherapy; Visual acuity