title: A chemoselective α-aminoxylation of aryl ketones: a cross dehydrogenative coupling reaction catalysed by Bu4NI.
abstract: Tetrabutyl ammonium iodide (TBAI) catalyzed α-aminoxylation of ketones using aq. TBHP as an oxidant has been accomplished. We have shown that the CDC (cross dehydrogenative coupling) reactions of ketones with N-hydroxyimidates such as N-hydroxysuccinimide (NHSI), N-hydroxyphthalimide (NHPI), N-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt) lead to the corresponding oxygenated products in good to moderate yields. The application of this method has been demonstrated by transforming a few coupled products into synthetically useful intermediates and products.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India. prabhu@orgchem.iisc.ernet.in.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Siddaraju
authors.forename: Kandikere Ramaiah
authors.initials: KR
authors.lastname: Prabhu