title: Upper Gastrointestinal Bleeding in Chinese Children: A Multicenter 10-Year Retrospective Study.
abstract: Objective This study aims to analyze the clinical and endoscopic presentations of upper gastrointestinal bleeding (UGIB) in the Chinese children. Methods A 10-year retrospective study was made on children with UGIB and undertaken esophagogastroduodenoscopy (EGD) from 4 tertiary referral centers in China. Results Of the 1218 children studied, the bleeding source was found in 76.4%. Erosive gastritis was the most common endoscopic finding (33.5%), followed by duodenal ulcer (23.2%). The proportion of erosive gastritis decreased with age (correlation coefficient = -0.787), and duodenal ulcer increased with age (correlation coefficient = 0.958). The bleeding source was more likely to be determined in children having EGDs within 48 hours (80.6% vs 67.9%). Conclusions In Chinese children with UGIB, erosive gastritis and duodenal ulcer were the leading causes, and their proportions varied with age. EGDs performed within 48 hours may improve the possibility of finding the source of bleeding.
authors.affiliation: Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Wuhan Women and Children Health Care Center, Shanghai, China.
authors.forename: Baoxiang
authors.initials: B
authors.lastname: Wang
authors.affiliation: Chengdu Women's and Children's Central Hospital, Chengdu, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Xinqiong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Wuhan Women and Children Health Care Center, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Mei
authors.affiliation: Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China chundixu55@163.com.
authors.forename: Chundi
authors.initials: C
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002681:China; D004381:Duodenal Ulcer / Q000150:complications / Q000175:diagnosis; D016145:Endoscopy, Digestive System; D005260:Female; D005756:Gastritis / Q000150:complications; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies
keywords: NSAIDs; children; esophagogastroduodenoscopy; etiology; upper gastrointestinal bleeding