title: Single organ variant of polyarteritis nodosa in epididymis.
abstract: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that typically affects medium-sized muscular arteries, with occasional involvement of small muscular arteries. Unlike some other vasculitides (e.g. microscopic polyarteritis, Wegener's granulomatosis) PAN is not associated with antineutrophil cytoplasmic antibodies. Patients typically present with systemic symptoms such as fever, weight loss, and malaise. The kidneys, skin, joints, muscles, nerves, and gastrointestinal tract are commonly involved, usually in some combination. PAN can affect any organ, but usually spare the lungs. Clinical variants or subsets of PAN include single-organ disease and cutaneous-only PAN. Scrotal involvement is rarely the first presenting sign. We herein report a case of 36-year-old man who presented with a swelling in the left epididymis, which was surgically removed. The swelling histopathologically showed necrotizing inflammation, fibrinoid necrosis of the medium-sized arteries of the epididymis and was diagnosed to be single organ variant of PAN.
authors.affiliation: Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Ketan
authors.initials: K
authors.lastname: Garg
authors.forename: Leelavathi
authors.initials: L
authors.lastname: Dawson
mesh_terms: D000328:Adult; D004822:Epididymis / Q000098:blood supply / Q000473:pathology; D006801:Humans; D008297:Male; D010488:Polyarteritis Nodosa / Q000000981:diagnostic imaging* / Q000601:surgery; D014463:Ultrasonography