title: Thermosensitive chitosan-based hydrogels for sustained release of ferulic acid on corneal wound healing.
abstract: Oxidative damage to cornea can be induced by alkaline chemical burn which may cause vision loss or blindness. Recent studies showed that exogenous application of natural antioxidants may be a potential treatment for corneal wound healing. However, low ocular bioavailability and short residence time are the limiting factors of topically administered antioxidants. Ferulic acid (FA) is a natural phenolic compound and an excellent antioxidant. The study was aimed to investigate the effects of FA in corneal epithelial cells (CECs) under oxidative stress and evaluate the feasibility of use the thermosensitive chitosan-based hydrogel containing FA for corneal wound healing. The results demonstrated that post-treatment of FA on CECs could decrease the inflammation-level and apoptosis. In the rabbit corneal alkali burn model, post-treatment FA-loaded hydrogel may promote the corneal wound healing. The results of study suggest that FA-loaded hydrogel may have the potential applications in treating corneal alkali burn.
authors.affiliation: Department of Ophthalmology, Taipei City Hospital, No. 145, Zhengzhou Rd., Datong Dist., Taipei 103, Taiwan, ROC; Institute of Public Health, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan, ROC. Electronic address: dac58@tpech.gov.tw.
authors.forename: Ching-Yao
authors.initials: CY
authors.lastname: Tsai
authors.affiliation: Department of Ophthalmology, Taipei City Hospital, No. 145, Zhengzhou Rd., Datong Dist., Taipei 103, Taiwan, ROC.
authors.forename: Lin-Chung
authors.initials: LC
authors.lastname: Woung
authors.affiliation: Institute of Pharmacology, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan, ROC.
authors.forename: Jiin-Cherng
authors.initials: JC
authors.lastname: Yen
authors.affiliation: Department of Ophthalmology, Taipei City Hospital, No. 145, Zhengzhou Rd., Datong Dist., Taipei 103, Taiwan, ROC.
authors.forename: Po-Chen
authors.initials: PC
authors.lastname: Tseng
authors.affiliation: Institute of Pharmacology, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan, ROC.
authors.forename: Shih-Hwa
authors.initials: SH
authors.lastname: Chiou
authors.affiliation: Institute of Anatomy & Cell Biology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: Yen-Jen
authors.initials: YJ
authors.lastname: Sung
authors.affiliation: Institute of Anatomy & Cell Biology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: Kuan-Ting
authors.initials: KT
authors.lastname: Liu
authors.affiliation: Institute of Pharmacology, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan, ROC; Department of Education and Research, Taipei City Hospital, No. 145, Zhengzhou Rd., Datong Dist., Taipei 103, Taiwan, ROC. Electronic address: yunghsin@ym.edu.tw.
authors.forename: Yung-Hsin
authors.initials: YH
authors.lastname: Cheng
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D002057:Burns, Chemical / Q000188:drug therapy* / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D003315:Cornea / Q000166:cytology; D003373:Coumaric Acids / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004195:Disease Models, Animal; D065546:Drug Liberation; D004847:Epithelial Cells / Q000187:drug effects; D005126:Eye Burns / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D020100:Hydrogels / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000633:toxicity; D011817:Rabbits; D012972:Sodium Hydroxide; D013696:Temperature; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D003692:Delayed-Action Preparations; D020100:Hydrogels; D012972:Sodium Hydroxide; D048271:Chitosan; C004999:ferulic acid; D006861:Hydrogen Peroxide
keywords: Chitosan; Corneal wound healing; Drug delivery; Ferulic acid; Oxidative stress