title: Should progesterone on the human chorionic gonadotropin day still be measured?
abstract: OBJECTIVE
  To evaluate in our setting whether there is currently a level of P on the hCG day (P-hCG) predictive of no pregnancy.
  
  
  METHODS
  Observational study of prospectively collected data of the P-hCG levels of stimulated IVF cycles.
  
  
  METHODS
  In vitro fertilization unit.
  
  
  METHODS
  All cycles of IVF/intracytoplasmic sperm injection with fresh embryo transfer performed between January 2009 and March 2014.
  
  
  METHODS
  None.
  
  
  METHODS
  Pregnancy rate.
  
  
  RESULTS
  Clinical pregnancy rate per ET was 38.7% and live birth rate was 29.1%. The P-hCG concentration was positively correlated to E2 on the hCG day, and the number of oocytes was negatively correlated to age. Progesterone on hCG day was higher among agonist- compared with antagonist-treated patients (mean ± SD: 1.13 ± 0.69 ng/mL vs. 0.97 ± 0.50 ng/mL) and among recombinant FSH compared with recombinant FSH + hMG stimulation (mean ± SD: 1.11 ± 0.58 ng/mL vs. 0.94 ± 0.50 ng/mL). Pregnancy rate was positively associated with the number of oocytes. There was no correlation between P-hCG value and pregnancy rate, overall or according to the type of treatment.
  
  
  CONCLUSIONS
  In our setting there is no P-hCG value differentiating a good from a poor cycle success rate.
  
  
  BACKGROUND
  NCT02323347.
authors.affiliation: Servicio de Medicina de la Reproducción, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain. Electronic address: pacmar@dexeus.com.
authors.forename: Francisca
authors.initials: F
authors.lastname: Martinez
authors.affiliation: Servicio de Medicina de la Reproducción, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodriguez
authors.affiliation: Servicio de Medicina de la Reproducción, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Devesa
authors.affiliation: Servicio de Medicina de la Reproducción, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Rosario
authors.initials: R
authors.lastname: Buxaderas
authors.affiliation: Servicio de Medicina de la Reproducción, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Gómez
authors.affiliation: Servicio de Medicina de la Reproducción, Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Buenaventura
authors.initials: B
authors.lastname: Coroleu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005298:Fertility / Q000187:drug effects; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D010062:Ovulation Induction / Q000379:methods*; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood*; D020554:Sperm Injections, Intracytoplasmic; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D011374:Progesterone; D004958:Estradiol
keywords: Clinical outcomes; ovarian stimulation; pregnancy rate; progesterone levels