title: Gender-specific and age-specific differences in unstable angina pectoris admissions: a population-based registry study in Finland.
abstract: OBJECTIVE
  To evaluate gender-specific and age-specific differences in the occurrence of unstable angina pectoris (UAP) caused admissions.
  
  
  METHODS
  Population-based retrospective registry study in Finland.
  
  
  METHODS
  All consecutive patients aged ≥30 years hospitalised with a primary diagnosis of UAP in 22 hospitals with a coronary catheterisation laboratory during 5/2000-10/2009.
  
  
  METHODS
  Gender-specific and age-specific differences and trends in occurrence of UAP admissions.
  
  
  RESULTS
  The study period included 27 282 admissions caused primarily by UAP. Of these, 61.9% occurred to men and 38.1% to women with age-adjusted relative risk (RR) of 1.85 (CI 1.61 to 2.14) for the male gender (p<0.0001). The standardised incidence rate of UAP during the whole study was 92.8 (CI 91.8 to 93.9)/100,000 person-years. The incidence rate increased gradually from 1.3 in the population aged 30-34 years to 268.0/100,000 in the population aged 75-84 years. Men had a 2.4-fold risk for UAP admission compared with women in the general population (incidence rate ratio 2.39; CI 2.24 to 2.56; p<0.0001). Gender difference was present in all age groups. UAP caused 22.4% of acute coronary syndrome admissions and 4.7% of all cardiovascular admissions. UAP was more likely to be the cause of cardiovascular admission in male patients (RR=1.25; CI 1.21 to 1.30, p<0.0001 compared with female patients), but there was no gender difference in acute coronary syndrome admissions. The incidence rate of UAP hospitalisations in the general population declined by an estimated 8% per study-year (p<0.0001). Declining incidence was evident regardless of gender and age.
  
  
  CONCLUSIONS
  Men have a 2.4-fold overall RR for UAP admission compared to women in the general population. Admissions due to UAP have a declining incidence trend across the adult Finnish population.
authors.affiliation: Heart Center, Turku University Hospital, Turku, Finland Department of Medicine, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
authors.forename: Ville
authors.initials: V
authors.lastname: Kytö
authors.affiliation: Division of Clinical Neurosciences, Neurology, Turku University Hospital, Turku, Finland Department of Neurology, University of Turku, Turku, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Sipilä
authors.affiliation: Clinical Research Center, Turku University Hospital, Turku, Finland Department of Public Health, University of Turku, Turku, Finland.
authors.forename: Päivi
authors.initials: P
authors.lastname: Rautava
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000453:epidemiology*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data* / Q000639:trends*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D017678:Sex Distribution