title: ChEBI in 2016: Improved services and an expanding collection of metabolites.
abstract: ChEBI is a database and ontology containing information about chemical entities of biological interest. It currently includes over 46,000 entries, each of which is classified within the ontology and assigned multiple annotations including (where relevant) a chemical structure, database cross-references, synonyms and literature citations. All content is freely available and can be accessed online at http://www.ebi.ac.uk/chebi. In this update paper, we describe recent improvements and additions to the ChEBI offering. We have substantially extended our collection of endogenous metabolites for several organisms including human, mouse, Escherichia coli and yeast. Our front-end has also been reworked and updated, improving the user experience, removing our dependency on Java applets in favour of embedded JavaScript components and moving from a monthly release update to a 'live' website. Programmatic access has been improved by the introduction of a library, libChEBI, in Java, Python and Matlab. Furthermore, we have added two new tools, namely an analysis tool, BiNChE, and a query tool for the ontology, OntoQuery.
authors.affiliation: Cheminformatics and Metabolism, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK hastings@ebi.ac.uk.
authors.forename: Janna
authors.initials: J
authors.lastname: Hastings
authors.affiliation: Cheminformatics and Metabolism, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
authors.forename: Gareth
authors.initials: G
authors.lastname: Owen
authors.affiliation: Cheminformatics and Metabolism, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
authors.forename: Adriano
authors.initials: A
authors.lastname: Dekker
authors.affiliation: Cheminformatics and Metabolism, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
authors.forename: Marcus
authors.initials: M
authors.lastname: Ennis
authors.affiliation: Cheminformatics and Metabolism, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
authors.forename: Namrata
authors.initials: N
authors.lastname: Kale
authors.affiliation: Cheminformatics and Metabolism, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Muthukrishnan
authors.affiliation: Cheminformatics and Metabolism, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Turner
authors.affiliation: Manchester Centre for Integrative Systems Biology, University of Manchester, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Swainston
authors.affiliation: Manchester Centre for Integrative Systems Biology, University of Manchester, UK.
authors.forename: Pedro
authors.initials: P
authors.lastname: Mendes
authors.affiliation: Cheminformatics and Metabolism, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Hinxton, UK steinbeck@ebi.ac.uk.
authors.forename: Christoph
authors.initials: C
authors.lastname: Steinbeck
mesh_terms: D000818:Animals; D062126:Databases, Chemical; D006801:Humans; D008660:Metabolism; D055432:Metabolomics; D051379:Mice; D012984:Software