title: Childhood Cumulative Risk Exposure and Adult Amygdala Volume and Function.
abstract: Considerable work indicates that early cumulative risk exposure is aversive to human development, but very little research has examined the neurological underpinnings of these robust findings. This study investigates amygdala volume and reactivity to facial stimuli among adults (mean 23.7 years of age, n = 54) as a function of cumulative risk exposure during childhood (9 and 13 years of age). In addition, we test to determine whether expected cumulative risk elevations in amygdala volume would mediate functional reactivity of the amygdala during socioemotional processing. Risks included substandard housing quality, noise, crowding, family turmoil, child separation from family, and violence. Total and left hemisphere adult amygdala volumes were positively related to cumulative risk exposure during childhood. The links between childhood cumulative risk exposure and elevated amygdala responses to emotionally neutral facial stimuli in adulthood were mediated by the corresponding amygdala volumes. Cumulative risk exposure in later adolescence (17 years of age), however, was unrelated to subsequent adult amygdala volume or function. Physical and socioemotional risk exposures early in life appear to alter amygdala development, rendering adults more reactive to ambiguous stimuli such as neutral faces. These stress-related differences in childhood amygdala development might contribute to the well-documented psychological distress as a function of early risk exposure.
authors.affiliation: Departments of Design and Environmental Analysis and of Human Development, Bronfenbrenner Center for Translational Research, Cornell University, Ithaca, New York.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Evans
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.|Yale Child Study Center, Yale University, New Haven, Connecticut.
authors.forename: James E
authors.initials: JE
authors.lastname: Swain
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: King
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.|Department of Psychiatry and Neuroscience, Wayne State University, Detroit, Michigan.
authors.forename: Arash
authors.initials: A
authors.lastname: Javanbakht
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
authors.forename: S Shaun
authors.initials: SS
authors.lastname: Ho
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
authors.forename: Michael
authors.initials: M
authors.lastname: Angstadt
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.
authors.forename: K Luan
authors.initials: KL
authors.lastname: Phan
authors.affiliation: Department of Neuroscience, University of Toledo, Toledo, Ohio.
authors.forename: Hong
authors.initials: H
authors.lastname: Xie
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
authors.forename: Israel
authors.initials: I
authors.lastname: Liberzon
mesh_terms: D000328:Adult; D000679:Amygdala / Q000000981:diagnostic imaging / Q000473:pathology*; D015331:Cohort Studies; D005149:Facial Expression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D011203:Poverty / Q000523:psychology; D011610:Psychosocial Deprivation; D012307:Risk Factors; D013315:Stress, Psychological / Q000000981:diagnostic imaging / Q000473:pathology* / Q000523:psychology; D014754:Violence; D055815:Young Adult
keywords: amygdala function; amygdala volume; children; cumulative risk