title: [Mean Platelet Volume in Children with Acute Gastroenteritis Caused by Entamoeba histolytica].
abstract: OBJECTIVE
  Mean platelet volume (MPV) is a marker of platelet activation, which is a determinant of inflammation. The first aim of the present study was to investigate the MPV levels in children with amebiasis and compare the MPV levels with healthy controls. The second aim of this study was to evaluate the relationship between MPV and other acute phase reactants.
  
  
  METHODS
  Seventy six patients with amebic gastroenteritis (mean age 2.64 ± 0.23 years) and 53 healthy controls (mean age 2.35 ± 0.28 years) were enrolled in the study. Entamoeba histolytica was determined in stool using rapid antigen test.
  
  
  RESULTS
  Complete blood count and C-reactive protein (CRP) levels were assessed for all children. MPV levels of patients with amebiasis were significantly higher than those of control children (8.79 ± 0.09 vs. 7.87 ± 0.09 fL, p = 0.000). Leukocyte and eosinophil counts, C-reactive protein and creatinine levels of the patients were higher than controls. Leukocyte count was positively correlated with MPV (r = 0.192, p < 0.05), platelet count (r = 0.278, p < 0.01), and CRP level (r = 0.205, p < 0.05).
  
  
  CONCLUSIONS
  In this MPV levels were significantly higher in children with amebiasis compared to controls. MPV can be used as an acute phase reactant in children with Entamoeba histolytica gastroenteritis.
authors.affiliation: Dr. Behçet Uz Çocuk Hastanesi, Çocuk Acil Bölümü, İzmir, Türkiye. dr.tanju35@hotmail.com.
authors.forename: Tanju
authors.initials: T
authors.lastname: Çelik
authors.forename: Ekrem
authors.initials: E
authors.lastname: Güler
authors.forename: Emel Ataş
authors.initials: EA
authors.lastname: Berksoy
authors.forename: Yelda
authors.initials: Y
authors.lastname: Sorguç
authors.forename: Nur
authors.initials: N
authors.lastname: Arslan
mesh_terms: D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004404:Dysentery, Amebic / Q000097:blood* / Q000469:parasitology; D004748:Entamoeba histolytica / Q000276:immunology / Q000302:isolation & purification; D004804:Eosinophils / Q000166:cytology; D005243:Feces / Q000469:parasitology; D005260:Female; D005759:Gastroenteritis / Q000097:blood* / Q000469:parasitology; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D063847:Mean Platelet Volume; D010976:Platelet Count
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein