title: [Analysis of sulfonamids and their metabolites in drinking water by high Performance liquid chromatography tandem mass spectrometry].
abstract: OBJECTIVE
  To develop a comprehensive method for simultaneous analysis of sulfonamides and their metabolites in drinking water by high performance liquid chromatography tandem mass spectrometry (LC-MS/MS).
  
  
  METHODS
  Different solid-phase extraction columns were compared with respect to the recovery of target drugs from drinking water. The drinking water samples were adjusted to 3 by HCl and purified by a mix mode cation-ion exchange solid-phase extraction (SPE), following determination using LG-MS/MS. A total of 21 sulfonamides were separated by a C15 column (2.1 mm x 100 mm, 1.7 µm) and analyzed under positive ion mode with multi-reaction monitoring. The matrix-matched external standard calibration was used for quantification.
  
  
  RESULTS
  The method quantification limits for 21 analytes were 0.03-0.63 ng/L with overall recoveries of 50.1%-114.9%, and the relative standard deviations less than 20%. The method was finally used to analyze sulfonamides in drinking water in Beijing, and 5 target compounds (sulfadiazine, sulfathiazole, sulfapyridine, trimethoprim and sulfamethazine) were detected at a concentration range of 0.08-32.54 ng/L.
  
  
  CONCLUSIONS
  This method could be applied in simultaneous analysis of sulfonamides and their metabolites in drinking water samples.
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Shuming
authors.initials: S
authors.lastname: Li
authors.forename: Xiangming
authors.initials: X
authors.lastname: Zhang
authors.forename: Yunfang
authors.initials: Y
authors.lastname: Wei
authors.forename: Meiyun
authors.initials: M
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D060766:Drinking Water / Q000737:chemistry*; D052616:Solid Phase Extraction; D013449:Sulfonamides / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014867:Water / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D060766:Drinking Water; D013449:Sulfonamides; D014874:Water Pollutants, Chemical; D014867:Water