title: Endogenous intoxication in helminthic invasion in men of reproductive age.
abstract: Helminthes have a systemic effect on the human body: the people in infested occur pathological changes in organs and tissues, violated the enzymatic, hormonal function and childbearing, suffering intestinal microflora develops immune deficiency, which affects the body's adaptive capabilities. Research aim: ?stimate endogenous intoxication of helminthiasis at molecular level at people of reproductive age.
  
  
  METHODS
  We examined 110 men of reproductive age. Of these, 50 men entered the control group, 60 men suffering with ascaridiasis invasion. To determine the content of middle molecules in the blood of persons investigated using the methodology Kovalevsky A.N. and Nifanteva O.E.
  
  
  RESULTS
  Average mass concentration of molecules in the blood of men under 36 years with ascaridiasis invasion ranged from 0.44 to 8.9 standard units, men 36-45 years - from 0.41 to 5.21 standard units 30% of men with ascaridiasis invasion under 36 years, the level of middle molecules in the blood exceeds 3.00 standard units, while men older age group of middle molecules content exceeding 3.00 standard units, was observed only in 11% of cases.
  
  
  CONCLUSIONS
  Thus, the concentration of middle molecules in the blood ascaridiasis invasion of men aged 35-45 years were significantly higher than in healthy individuals, indicating that expressed endogenous intoxication caused by helminthes invasions. Endogenous intoxication is more pronounced in those aged 18-35 years, having a larger, compared with the older age group, the reproductive potential. Perhaps this phenomenon is associated with more intense metabolic processes, typical for the age group 18-35 years.
authors.affiliation: Karaganda State Medical University, Department of Molecular Biology and Medical Genetics, Kazakhstan.
authors.forename: E B
authors.initials: EB
authors.lastname: Kultanova
authors.affiliation: Karaganda State Medical University, Department of Molecular Biology and Medical Genetics, Kazakhstan.
authors.forename: Z D
authors.initials: ZD
authors.lastname: Toleuova
authors.affiliation: Karaganda State Medical University, Department of Molecular Biology and Medical Genetics, Kazakhstan.
authors.forename: M M
authors.initials: MM
authors.lastname: Mukhsunov
authors.affiliation: Karaganda State Medical University, Department of Molecular Biology and Medical Genetics, Kazakhstan.
authors.forename: A K
authors.initials: AK
authors.lastname: Shakarimov
authors.affiliation: Karaganda State Medical University, Department of Molecular Biology and Medical Genetics, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Suleimen
authors.affiliation: Karaganda State Medical University, Department of Molecular Biology and Medical Genetics, Kazakhstan.
authors.forename: B T
authors.initials: BT
authors.lastname: Yessilbayeva
authors.affiliation: Karaganda State Medical University, Department of Molecular Biology and Medical Genetics, Kazakhstan.. Electronic address: kultanov.berik@mail.ru.
authors.forename: Kultanov B
authors.initials: KB
authors.lastname: Zh