title: Nanomedical innovation: the SEON-concept for an improved cancer therapy with magnetic nanoparticles.
abstract: Nanomedicine offers tremendous opportunities for the development of novel therapeutic and diagnostic tools. During the last decades, extensive knowledge was gained about stabilizing and the coating of nanoparticles, their functionalization for drug binding and drug release and possible strategies for therapies and diagnostics of different diseases. Most recently, more and more emphasis has been placed on nanotoxicology and nanosafety aspects. The section of experimental oncology and nanomedicine developed a concept for translating this knowledge into clinical application of magnetic drug targeting for the treatment of cancer and other diseases using superparamagnetic iron oxide nanoparticles. This approach includes reproducible synthesis, detailed characterization, nanotoxicological testing, evaluation in ex vivo models, preclinical animal studies and production of superparamagnetic iron oxide nanoparticles according to good manufacturing practice regulations.
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Lyer
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Tietze
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Unterweger
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Zaloga
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Raminder
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Jasmin
authors.initials: J
authors.lastname: Matuszak
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Marina
authors.initials: M
authors.lastname: Poettler
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Ralf P
authors.initials: RP
authors.lastname: Friedrich
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.|Department of Otorhinolaryngology, Section of Phoniatrics & Pediatric Audiology, Head & Neck Surgery, University Hospital Erlangen, Bohlenplatz 21, 91054 Erlangen, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Duerr
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Iwona
authors.initials: I
authors.lastname: Cicha
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Janko
authors.affiliation: Department of Otorhinolaryngology, Section of Experimental Oncology & Nanomedicine (SEON), Head & Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Alexiou
mesh_terms: D006801:Humans; D008280:Magnetics; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*
keywords: SEON-concept; cancer; chemotherapy; drug delivery; imaging; iron oxide nanoparticles; magnetic drug targeting; nanomedicine; nanotechnology; oncology