title: Coagulation Parameters and Risk of Progressive Hemorrhagic Injury after Traumatic Brain Injury: A Systematic Review and Meta-Analysis.
abstract: Intracranial hemorrhage (ICH) after traumatic brain injury (TBI) commonly increases in size and coagulopathy has been implicated in such progression. Our aim is to perform a meta-analysis to assess their relationship. Cochrane library, PubMed, and EMBASE were searched for literatures. Pooled effect sizes and 95% confidential intervals (CIs) were calculated using random-effects model. We included six studies, involving 1700 participants with 540 progressive hemorrhagic injuries (PHIs). Our findings indicate that PT, D-dimer level, and INR value are positively associated with the risk of PHI. Higher level of PLT and Fg seemed to suggest a lower risk of PHI. Among these parameters, higher D-dimer level and INR value would possess more powerful strength in predicting PHI.
authors.affiliation: Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Danfeng
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Shun
authors.initials: S
authors.lastname: Gong
authors.affiliation: Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Junyu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Sheng
authors.affiliation: Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zou
authors.affiliation: Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Hou
mesh_terms: D001777:Blood Coagulation; D001930:Brain Injuries / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D020198:Intracranial Hemorrhage, Traumatic / Q000097:blood* / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008955:Models, Cardiovascular