title: The Significance of Serum CA-125 Elevation in Chinese Patients with Primary Budd-Chiari Syndrome: A Multicenter Study.
abstract: Objective. To investigate the serum level of CA-125 and its corresponding clinical significance in Chinese patients with primary BCS. Methods. Serum CA-125 was measured in 243 patients with primary BCS receiving interventional treatment in the participating hospitals and in 120 healthy volunteers. The correlation between serum CA-125 levels and ascites volume, liver function, and prognosis was analyzed. Results. Serum CA-125 was significantly elevated in BCS patients compared to healthy volunteers (P < 0.001). Higher levels of CA-125 were found in BCS patients with abnormal hepatic function and low serum albumin levels and in patients with high volume of ascites compared to patients without these abnormalities. Serum CA-125 levels significantly correlated with ascites volume, serum level of alanine aminotransferase, aspartate aminotransferase, albumin, and Rotterdam BCS scores. The follow-up study indicated that the survival rate and asymptomatic survival rate after interventional treatment were lower in BCS patients with serum CA-125 > 175 U/mL (P < 0.05). Conclusion. Serum CA-125 was significantly higher in patients with primary BCS and had a positive correlation with the volume of ascites, severity of liver damage, and poor prognosis. Thus the serum CA-125 levels may be used to estimate the severity and prognosis of BCS in Chinese patients.
authors.affiliation: Department of Interventional Radiology, Anhui Provincial Hospital, Hefei, Anhui 230001, China.
authors.forename: De-Lei
authors.initials: DL
authors.lastname: Cheng
authors.affiliation: Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Interventional Radiology, Anhui Provincial Hospital, Hefei, Anhui 230001, China.
authors.forename: Wei-Fu
authors.initials: WF
authors.lastname: Lv
authors.affiliation: Department of Radiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221002, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hua
authors.affiliation: Department of Radiology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221002, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Du
authors.affiliation: Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China.
authors.forename: Qing-Qiao
authors.initials: QQ
authors.lastname: Zhang