title: Spatially regularized machine learning for task and resting-state fMRI.
abstract: BACKGROUND
  Reliable mapping of brain function across sessions and/or subjects in task- and resting-state has been a critical challenge for quantitative fMRI studies although it has been intensively addressed in the past decades.
  
  
  METHODS
  A spatially regularized support vector machine (SVM) technique was developed for the reliable brain mapping in task- and resting-state. Unlike most existing SVM-based brain mapping techniques, which implement supervised classifications of specific brain functional states or disorders, the proposed method performs a semi-supervised classification for the general brain function mapping where spatial correlation of fMRI is integrated into the SVM learning. The method can adapt to intra- and inter-subject variations induced by fMRI nonstationarity, and identify a true boundary between active and inactive voxels, or between functionally connected and unconnected voxels in a feature space.
  
  
  RESULTS
  The method was evaluated using synthetic and experimental data at the individual and group level. Multiple features were evaluated in terms of their contributions to the spatially regularized SVM learning. Reliable mapping results in both task- and resting-state were obtained from individual subjects and at the group level.
  
  
  METHODS
  A comparison study was performed with independent component analysis, general linear model, and correlation analysis methods. Experimental results indicate that the proposed method can provide a better or comparable mapping performance at the individual and group level.
  
  
  CONCLUSIONS
  The proposed method can provide accurate and reliable mapping of brain function in task- and resting-state, and is applicable to a variety of quantitative fMRI studies.
authors.affiliation: Department of Electrical Engineering, School of Engineering, Widener University, Kirkbride Hall, Room 369, One University Place, Chester, PA 19013, United States. Electronic address: xmsong@widener.edu.
authors.forename: Xiaomu
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
authors.forename: Lawrence P
authors.initials: LP
authors.lastname: Panych
authors.affiliation: Brain Imaging and Analysis Center, Duke University Medical Center, Box 3918, Hock Plaza, Durham, NC 27710, United States.
authors.forename: Nan-kuei
authors.initials: NK
authors.lastname: Chen
mesh_terms: D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D066264:Datasets as Topic; D005385:Fingers / Q000502:physiology; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008606:Mental Processes / Q000502:physiology; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D015203:Reproducibility of Results; D012146:Rest; D060388:Support Vector Machine; D014796:Visual Perception / Q000502:physiology
keywords: Outlier detection; Quantitative fMRI; Spatial regularization; Support vector machine