title: T cells in tumor microenvironment.
abstract: Tumors progress in a specific area, which supports its development, spreading or shrinking in time with the presence of different factors that effect the fate of the cancer cells. This specialized site is called "tumor microenvironment" and has a composition of heterogenous materials. The immune cells are also residents of this stromal, cancerous, and inflammatory environment, and their types, densities, or functional differences are one of the key factors that mediate the fate of a tumor. T cells as a vital part of the immune system also are a component of tumor microenvironment, and their roles have been elucidated in many studies. In this review, we focused on the immune system components by focusing on T cells and detailed T helper cell subsets in tumor microenvironment and how their behaviors affect either the tumor or the patient's outcome.
authors.affiliation: Department of Molecular Biology and Genetics, Molecular Immunology and Gene Regulation Laboratory, Izmir Institute of Technology, Urla, 35430, İzmir, Turkey.|Faculty of Life and Natural Sciences, Abdullah Gul University, 38080, Kayseri, Turkey.
authors.forename: Yağmur
authors.initials: Y
authors.lastname: Kiraz
authors.affiliation: Department of Molecular Biology and Genetics, Molecular Immunology and Gene Regulation Laboratory, Izmir Institute of Technology, Urla, 35430, İzmir, Turkey.|Faculty of Life and Natural Sciences, Abdullah Gul University, 38080, Kayseri, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Baran
authors.affiliation: Department of Molecular Biology and Genetics, Molecular Immunology and Gene Regulation Laboratory, Izmir Institute of Technology, Urla, 35430, İzmir, Turkey. aytennalbant@iyte.edu.tr.
authors.forename: Ayten
authors.initials: A
authors.lastname: Nalbant
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000166:cytology; D018450:Disease Progression; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007107:Immune System; D007249:Inflammation; D008214:Lymphocytes / Q000166:cytology; D008264:Macrophages / Q000166:cytology; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology*; D058504:Th17 Cells / Q000166:cytology; D016896:Treatment Outcome; D059016:Tumor Microenvironment
keywords: Cancer immunology; T cells; T helper cells; Th17 cells; Tumor microenvironment