title: Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder: The Role of Endocrine Disruptors in Autism Etiopathogenesis.
abstract: The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), and bisphenol A (BPA), 1 of the endocrine disruptors, among phthalates. The study included 48 children with autism spectrum disorder (27 boys, 21 girls) and 41 healthy subjects (24 boys, 17 girls) as controls. Serum MEHP, DEHP, and BPA levels were measured by using high-performance liquid chromatography. Children with autism spectrum disorder had significantly increased serum MEHP, DEHP, and BPA concentrations (0.47 ± 0.14 µg/ml, 2.70 ± 0.90 µg/ml, 1.25 ± 0.30 ng/ml) compared to healthy control subjects (0.29 ± 0.05 µg/ml, 1.62 ± 0.56 µg/ml, 0.88 ± 0.18 ng/ml) respectively (P = .000). The fact that higher serum MEHP, DEHP, and BPA were found levels in the autism spectrum disorder group compared to healthy controls suggests that endocrine disruptors may have a role in the pathogenesis of autism spectrum disorders.
authors.affiliation: Department of Pediatrics, Division of Pediatric Nutrition and Metabolism, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Kardas
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Ayse Kacar
authors.initials: AK
authors.lastname: Bayram
authors.affiliation: Department of Child Psychiatry, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Demirci
authors.affiliation: Department of Pediatrics, Division of Pediatric Endocrinology, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Leyla
authors.initials: L
authors.lastname: Akin
authors.affiliation: Department of Child Psychiatry, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Ozmen
authors.affiliation: Department of Pediatrics, Division of Pediatric Nutrition and Metabolism, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kendirci
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Canpolat
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Didem Behice
authors.initials: DB
authors.lastname: Oztop
authors.affiliation: Department of Biochemistry, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Narin
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Gumus
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Sefer
authors.initials: S
authors.lastname: Kumandas
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, School of Medicine, Erciyes University, Kayseri, Turkey huseyinper@yahoo.com.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Per
mesh_terms: D000067877:Autism Spectrum Disorder / Q000097:blood* / Q000150:complications*; D001559:Benzhydryl Compounds / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D004051:Diethylhexyl Phthalate / Q000031:analogs & derivatives* / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D010636:Phenols / Q000097:blood*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004051:Diethylhexyl Phthalate; D010636:Phenols; C016599:mono-(2-ethylhexyl)phthalate; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: autism spectrum disorders; bisphenol A; children; endocrine disruptors; phthalates