title: Pseudellones A-C, Three Alkaloids from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42-3.
abstract: Pseudellones A and B (1 and 2), a pair of irregularly bridged epimonothiodiketopiperazine diastereomers constructed from unusual 3-indolylglycine and alanine residues, and an alkaloid pseudellone C (3) possessing a unique skeleton were isolated from the marine-derived fungus Pseudallescheria ellipsoidea F42-3. Their structures were determined by spectroscopic data, ECD calculation, and X-ray single crystal diffraction. The biogenetic pathways of 1-3 were proposed, and 1H-indole-3-carboxylic acid (4), a plausible biosynthetic intermediate, was coisolated.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.|Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University , Guangzhou 510006, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University , Guangzhou 510275, China.
authors.forename: Hou-Jin
authors.initials: HJ
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.
authors.forename: Meng-Yang
authors.initials: MY
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.
authors.forename: Ying-Chen
authors.initials: YC
authors.lastname: Ju
authors.affiliation: Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University , Guangzhou 510006, China.
authors.forename: Lai-You
authors.initials: LY
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.|Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China.
authors.forename: De-Po
authors.initials: DP
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.|Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006, China.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Lan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D018360:Crystallography, X-Ray; D005658:Fungi; D007211:Indoles; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011541:Pseudallescheria / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D007211:Indoles; C000605683:pseudellone A; C000605684:pseudellone B; C000605685:pseudellone C; C012382:indole-3-carboxylic acid