title: IMPlicating Mesenchymal Imp1 in Colitis-Associated Cancer.
abstract: Chronic inflammation and associated pathways are significant facilitators of many disease states, including malignancies. In the context of cancer, fibroblasts can actively regulate both inflammation and carcinogenesis. In this issue, Hamilton and colleagues describe a fibroblast-specific role of the RNA binding protein Imp1 in suppression of intestinal inflammatory responses and development of colitis-associated cancer.
authors.affiliation: Blood Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
authors.forename: Ekaterina K
authors.initials: EK
authors.lastname: Koltsova
authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania. sergey.grivennikov@fccc.edu.
authors.forename: Sergei I
authors.initials: SI
authors.lastname: Grivennikov
mesh_terms: D000818:Animals; D006801:Humans; D016601:RNA-Binding Proteins / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D016601:RNA-Binding Proteins