title: Unusual fungal sepsis of Alternaria alternata in acute lymphoblastic leukaemia in an adult patient.
abstract: We report a case of unusual fungal sepsis of Alternaria alternata in a patient of acute lymphoblastic leukaemia in 62-year-old male who presented with complaints of 'off and on' fever with decreased oral intake. On evaluation, haemogram showed low platelet count and 68% blast cells in peripheral blood. On flow cytometry of peripheral blood, the gated blasts (approximately 55%) highly express CD45, CD10, CD19, CD22 and condition was diagnosed as acute lymphoblastic leukaemia. He was started on standard induction treatment along with supportive therapies. During the course of treatment, two sets of paired blood cultures were sent 48 h apart. All of blood cultures were done on Bac-T alert 3D system. All of them yielded fungus. The fungus was then grown on Sabouraud's Dextrose agar media. It was identified as A. alternata. The patient condition worsened and later had cardiac arrest in ICU and could not be revived.
authors.affiliation: Department of Laboratory Medicine, Max Super Speciality Hospital, Patparganj, New Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Jain
authors.forename: B
authors.initials: B
authors.lastname: Tarai
authors.forename: P
authors.initials: P
authors.lastname: Tuli
authors.forename: P
authors.initials: P
authors.lastname: Das
mesh_terms: D000528:Alternaria / Q000302:isolation & purification*; D060487:Alternariosis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D017809:Fatal Outcome; D006323:Heart Arrest; D006801:Humans; D008297:Male; D008828:Microbiological Techniques; D008853:Microscopy; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D018805:Sepsis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*