title: Innate lymphoid cells in inflammatory bowel diseases.
abstract: It is generally believed that inflammatory bowel diseases (IBD) are caused by an aberrant immune response to environmental triggers in genetically susceptible individuals. The exact contribution of the adaptive and innate immune system has not been elucidated. However, recent advances in treatments targeting key inflammatory mediators such as tumour necrosis factor highlight the crucial role of the innate immune system in IBD. Innate lymphoid cells (ILCs) have recently been identified to play an important role in immune mediated inflammatory diseases. In this review we recapitulate the current knowledge on ILCs in IBD.
authors.affiliation: Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Electronic address: c.p.peters@amc.uva.nl.
authors.forename: C P
authors.initials: CP
authors.lastname: Peters
authors.affiliation: Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge Karolinska Institutet, CIM, F59, S-14186 Stockholm, Sweden. Electronic address: jenny.mjosberg@ki.se.
authors.forename: J M
authors.initials: JM
authors.lastname: Mjösberg
authors.affiliation: Department of Celbiology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Electronic address: j.h.bernink@amc.uva.nl.
authors.forename: J H
authors.initials: JH
authors.lastname: Bernink
authors.affiliation: Department of Celbiology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Electronic address: hergen.spits@amc.uva.nl.
authors.forename: H
authors.initials: H
authors.lastname: Spits
mesh_terms: D000818:Animals; D019138:Antibodies, Blocking / Q000627:therapeutic use; D004198:Disease Susceptibility; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy / Q000379:methods*; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000628:therapy; D007371:Interferon-gamma / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D019138:Antibodies, Blocking; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma
keywords: Anti-TNF; Crohn’s disease; IBD; IFN-γ; ILC; Innate lymphoid cells; Ulcerative colitis