title: Association between airflow limitation severity and arterial stiffness as determined by the brachial-ankle pulse wave velocity: a cross-sectional study.
abstract: Objective Chronic obstructive pulmonary disease (COPD) is often associated with concomitant systemic manifestations and comorbidities, such as cardiovascular disease. There are limited data regarding airflow limitation (AL) and atherosclerosis in Japanese patients, and the potential association between AL and arterial stiffness has not yet been investigated in Japanese patients. Therefore, the purpose of this study was to investigate the association between AL severity and arterial stiffness using the brachial-ankle pulse wave velocity (baPWV). Methods This cross-sectional study included 1,356 subjects aged 40-79 years without clinical cardiovascular diseases who underwent a comprehensive health screening that included spirometry, the baPWV measurement, and blood sampling during medical check-ups in 2009 at the Japanese Red Cross Kumamoto Health Care Center. AL was defined in accordance with the Global Initiative for COPD criteria (forced expiratory volume in one second / forced vital capacity of < 0.7). A cut-off baPWV value of >1,400 cm/s was used for risk prediction and screening. Results The average baPWV (SD) results were 1,578.0 (317.9), 1,647.3 (374.4), and 1,747.3 (320.1) cm/s in the patients with a normal pulmonary function, mild AL, and moderate-to-severe AL, respectively (p< 0.001). Using logistic regression models adjusted for the age, body mass index, smoking status, hypersensitive C-reactive protein levels, hypertension, hyperglycemia, and dyslipidemia, an increased baPWV (>1,400 cm/s) was significantly associated with moderate-to-severe AL compared with a normal pulmonary function (odds ratio=2.76; 95% confidence intervals, 1.37-5.55; p=0.004). Conclusion Our results indicated an association between AL and increased arterial stiffness. Arterial stiffness may therefore worsen with an increase in the severity of AL.
authors.affiliation: Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Oda
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Omori
authors.forename: Ayumi
authors.initials: A
authors.lastname: Onoue
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Cui
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.forename: Hironori
authors.initials: H
authors.lastname: Yada
authors.forename: Aya
authors.initials: A
authors.lastname: Hisada
authors.forename: Wataru
authors.initials: W
authors.lastname: Miyazaki
authors.forename: Noritaka
authors.initials: N
authors.lastname: Higashi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogata
authors.forename: Takahiko
authors.initials: T
authors.lastname: Katoh
mesh_terms: D000328:Adult; D000368:Aged; D000842:Ankle / Q000098:blood supply*; D055109:Ankle Brachial Index / Q000379:methods*; D044466:Asian People; D001783:Blood Flow Velocity; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D063177:Pulse Wave Analysis; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D059289:Vascular Stiffness
chemical_list: D002097:C-Reactive Protein