title: Synthesis of Functionalized Pyrazoles via Vanadium-Catalyzed C-N Dehydrogenative Cross-Coupling and Fluorescence Switch-On Sensing of BSA Protein.
abstract: Vanadium-catalyzed C-N dehydrogenative cross-coupling of alkenyl hydrazones leading to functionalized pyrazoles is described in a 1:1 mixture of toluene/H2O using air as the terminal oxidant. Significant practical features include use of the commercial nontoxic VOSO4 as a recyclable catalyst, mild reaction conditions, scalability, and the broad substrate scope. Some of the product pyrazoles exhibit interesting photophysical properties. Fluorescence light-up sensing of BSA protein by one of the pyrazoles is also highlighted.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati-781039, India.
authors.forename: Dinabandhu
authors.initials: D
authors.lastname: Sar
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati-781039, India.
authors.forename: Raghunath
authors.initials: R
authors.lastname: Bag
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati-781039, India.
authors.forename: Afsana
authors.initials: A
authors.lastname: Yashmeen
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati-781039, India.
authors.forename: Subhendu Sekhar
authors.initials: SS
authors.lastname: Bag
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati-781039, India.
authors.forename: Tharmalingam
authors.initials: T
authors.lastname: Punniyamurthy
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D005453:Fluorescence; D006835:Hydrazones / Q000737:chemistry; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000032:analysis; D017968:Vanadium Compounds / Q000737:chemistry
chemical_list: D000475:Alkenes; D006835:Hydrazones; D011720:Pyrazoles; D017968:Vanadium Compounds; D012710:Serum Albumin, Bovine; C034028:vanadyl sulfate