title: Electrically stimulating prefrontal cortex at retrieval improves recollection accuracy.
abstract: Neuroimaging and brain damage studies suggest that dorsolateral prefrontal cortex (dlPFC) is involved in the cognitive control of episodic recollection. If dlPFC is causally involved in retrieval, then transcranial direct current stimulation (tDCS) of this brain region should increase recollection accuracy, especially when recollection is difficult and requires cognitive control. Here, we report the first brain stimulation experiment to directly test this hypothesis. We administered tDCS to dlPFC immediately after studying to-be-learned material but just prior to recollection testing, thereby targeting retrieval processes. We found that stimulation of dlPFC significantly increased recollection accuracy, relative to a no-stimulation sham condition and also relative to active stimulation of a comparison region in left parietal cortex. There was no significant difference in the size of this increase between hemispheres. Moreover, these dlPFC stimulation effects were behaviorally selective, increasing accuracy only when participants needed to recollect difficult information. Electrically stimulating dlPFC allowed people to more accurately recollect specific details of their experiences, demonstrating a causal role of dlPFC in the retrieval of episodic memories.
authors.affiliation: The University of Chicago, Chicago, IL, USA. Electronic address: sjgray@uchicago.edu.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Gray
authors.affiliation: The University of Chicago, Chicago, IL, USA.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Brookshire
authors.affiliation: The University of Chicago, Chicago, IL, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Casasanto
authors.affiliation: The University of Chicago, Chicago, IL, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Gallo
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D065908:Transcranial Direct Current Stimulation; D055815:Young Adult
keywords: Brain stimulation; Criterial recollection; Retrieval monitoring; Source memory; tDCS