title: Imaging of acute and subacute toxicities of cancer therapy in children.
abstract: Effective cancer therapies have resulted in significant improvement in survival. However, treatment-related acute and subacute complications are a cause of significant morbidity and mortality. Effects of cancer therapy in children can be seen early in the survival period or later in life in almost all organ systems of the body. Many of these conditions are evaluated by imaging and some are diagnosed based on characteristic imaging features. This article aims to discuss acute and subacute toxicities of cancer therapy in children involving multiple organ systems, pulmonary, gastrointestinal, hepatobiliary, genitourinary and musculoskeletal systems with emphasis on those in which imaging plays a role in diagnosis or management. We also discuss the role of imaging and choice of imaging modalities in these conditions.
authors.affiliation: Department of Diagnostic Imaging, The Hospital For Sick Children and University of Toronto, 555 University Ave., Toronto, ON, M5G 1X8, Canada. drgovindchavhan@yahoo.com.
authors.forename: Govind B
authors.initials: GB
authors.lastname: Chavhan
authors.affiliation: Department of Medical Imaging, Royal University Hospital, Saskatoon, SK, Canada.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Babyn
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, The Hospital For Sick Children and University of Toronto, Toronto, ON, Canada.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Nathan
authors.affiliation: Department of Diagnostic Imaging and Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.|Department of Radiology, University of Tennessee School of Health Sciences Memphis, Memphis, TN, USA.
authors.forename: Sue C
authors.initials: SC
authors.lastname: Kaste
mesh_terms: D000208:Acute Disease; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003952:Diagnostic Imaging / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy*; D011183:Postoperative Complications / Q000175:diagnosis*; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer therapy; Children; Imaging; Toxicities