title: Multifocal chorioretinitis with progressive subretinal fibrosis in a young child.
abstract: Progressive subretinal fibrosis with uveitis (PSFU) syndrome is a rare clinical entity presenting with multifocal granulomatous chorioretinitis and subsequently developing extensive subretinal fibrosis over weeks or months. Subretinal fibrosis affecting the macula may cause profound and permanent vision loss. We report the presentation and management of this condition in a child, to our knowledge, the youngest reported. The condition caused substantial visual loss and required high-dose systemic corticosteroid and immunosuppression with methotrexate and ciclosporin to control aggressive intraocular inflammation.
authors.affiliation: Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, UK.
authors.forename: Laura R
authors.initials: LR
authors.lastname: Steeples
authors.affiliation: Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, UK.
authors.forename: Jane
authors.initials: J
authors.lastname: Ashworth
authors.affiliation: Manchester Royal Eye Hospital, Manchester, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Jones
mesh_terms: D001766:Blindness / Q000209:etiology*; D002675:Child, Preschool; D002825:Chorioretinitis / Q000150:complications*; D005128:Eye Diseases / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008488:Medical Illustration; D012160:Retina / Q000473:pathology*