title: The roles of stem cell memory T cells in hematological malignancies.
abstract: Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory T (TSCM) cells, was shown to be one of the most favorable subsets for ACT. TSCM has high self-renewal capacity and is associated with superior T cell engraftment, persistence, and antitumor immunity. In this review, we focused on the characteristics of antigen-specific TSCM cells and discussed their potential for immunotherapy targeting hematological malignancies.
authors.affiliation: Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. lingxu114@163.com.|Institute of Hematology, Jinan University, Guangzhou, 510632, China. lingxu114@163.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. jnuyikai@163.com.|Institute of Hematology, Jinan University, Guangzhou, 510632, China. jnuyikai@163.com.
authors.forename: Yikai
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. jdluogx@163.com.
authors.forename: Gengxin
authors.initials: G
authors.lastname: Luo
authors.affiliation: Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. yangqiuli@hotmail.com.|Institute of Hematology, Jinan University, Guangzhou, 510632, China. yangqiuli@hotmail.com.|Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, China. yangqiuli@hotmail.com.
authors.forename: Yangqiu
authors.initials: Y
authors.lastname: Li
mesh_terms: D002454:Cell Differentiation / Q000276:immunology; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D016130:Immunophenotyping; D016219:Immunotherapy, Adoptive / Q000379:methods*; D018448:Models, Immunological; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000637:transplantation*