title: Exercise and the Regulation of Skeletal Muscle Hypertrophy.
abstract: Skeletal muscle is a critical organ serving as the primary site for postprandial glucose disposal and the generation of contractile force. The size of human skeletal muscle mass is dependent upon the temporal relationship between changes in muscle protein synthesis (MPS) and muscle protein breakdown. The aim of this chapter is to review our current understanding of how resistance exercise influences protein turnover with a specific emphasis on the molecular factors regulating MPS. We also will discuss recent data relating to the prescription of resistance exercise to maximize skeletal muscle hypertrophy. Finally, we evaluate the impact of age and periods of disuse on the loss of muscle mass and the controversy surround the etiology of muscle disuse atrophy.
authors.affiliation: Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Chris
authors.initials: C
authors.lastname: McGlory
authors.affiliation: Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. Electronic address: phillis@mcmaster.ca.
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Phillips
mesh_terms: D000818:Animals; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006984:Hypertrophy; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000378:metabolism; D018482:Muscle, Skeletal / Q000473:pathology*; D014176:Protein Biosynthesis; D055070:Resistance Training; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases
keywords: Hypertrophy; P70S6K1; Resistance exercise; Skeletal muscle; mTORC1