title: Wnt signaling in bone and muscle.
abstract: Wnt signaling plays key roles in many aspects of development. In this review, we will briefly describe the components of signaling pathways induced by Wnt ligands and then describe the current state of research as this applies to aspects of development and disease as it relates to skeletal muscle and bone. We will conclude with a discussion of the parallels and differences in Wnt signaling in these two contexts and how these pathways are being (or could potentially be) targeted for therapeutic treatment of musculoskeletal diseases. This article is part of a Special Issue entitled "Muscle Bone Interactions".
authors.affiliation: Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: mrudnicki@ohri.ca.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Rudnicki
authors.affiliation: Center for Skeletal Disease and Tumor Metastasis, Van Andel Research Institute, Grand Rapids, MI, USA. Electronic address: bart.williams@vai.org.
authors.forename: Bart O
authors.initials: BO
authors.lastname: Williams
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000235:genetics / Q000502:physiology*
chemical_list: D051153:Wnt Proteins
keywords: Bone; Frizzled; Muscle; Osteoblasts; Satellite stem cells; Wnt