title: Neutrophil to lymphocyte ratio: a novel marker for predicting hospital mortality of patients with acute type A aortic dissection.
abstract: BACKGROUND
  The inflammatory process has been reported to be associated with aortic dissection (AD) from the development to the prognosis. The aim of the study was to investigate a relationship between the neutrophil to lymphocyte ratio (NLR) and in-hospital outcomes in patients with acute aortic dissection (AAD) who underwent surgical repair.
  
  
  METHODS
  One hundred and eighty-four patients who were admitted with the diagnosis of type A AAD who underwent surgical repair at two large tertiary hospitals. According to their NLR, 91 patients had high NLR (>6.0) and 93 patients had low NLR (⩽6.0).
  
  
  RESULTS
  The frequency of major bleeding, hospital-related infection, multi-organ dysfunction and mortality in hospital were higher in the high NLR group compared to the low NLR group. NLR, WBC count and operation duration were found to be independent predictors for in-hospital mortality.
  
  
  CONCLUSIONS
  The novel inflammatory marker NLR may be used to predict worse outcomes and hospital mortality in patients with AAD treated by surgical repair.
authors.affiliation: 1 Kartal Kosuyolu Education and Research Hospital, Cardiology Department, Istanbul, Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kalkan
authors.affiliation: 2 Mehmet Akif Ersoy Education and Research Hospital, Cardiology Department, Istanbul, Turkey.
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Kalkan
authors.affiliation: 3 Mersin University School of Medicine, Cardiology Department, Mersin, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gündeş
authors.affiliation: 4 Kartal Kosuyolu Education and Research Hospital, Cardiovascular Surgery Department, Istanbul, Turkey.
authors.forename: Mehmed
authors.initials: M
authors.lastname: Yanartaş
authors.affiliation: 1 Kartal Kosuyolu Education and Research Hospital, Cardiology Department, Istanbul, Turkey.
authors.forename: Semi
authors.initials: S
authors.lastname: Oztürk
authors.affiliation: 1 Kartal Kosuyolu Education and Research Hospital, Cardiology Department, Istanbul, Turkey.
authors.forename: Ahmet Seyfeddin
authors.initials: AS
authors.lastname: Gurbuz
authors.affiliation: 2 Mehmet Akif Ersoy Education and Research Hospital, Cardiology Department, Istanbul, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Ozturk
authors.affiliation: 5 Mehmet Akif Ersoy Education and Research Hospital, Cardiovascular Surgery Department, Istanbul, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Iyigun
authors.affiliation: 1 Kartal Kosuyolu Education and Research Hospital, Cardiology Department, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akcakoyun
authors.affiliation: 1 Kartal Kosuyolu Education and Research Hospital, Cardiology Department, Istanbul, Turkey.
authors.forename: Mehmet Yunus
authors.initials: MY
authors.lastname: Emiroglu
authors.affiliation: 4 Kartal Kosuyolu Education and Research Hospital, Cardiovascular Surgery Department, Istanbul, Turkey.
authors.forename: Mehmet Altuğ
authors.initials: MA
authors.lastname: Tuncer
authors.affiliation: 4 Kartal Kosuyolu Education and Research Hospital, Cardiovascular Surgery Department, Istanbul, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Koksal
mesh_terms: D000784:Aortic Dissection / Q000097:blood* / Q000401:mortality*; D003430:Cross-Sectional Studies; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology
keywords: NLR; aortic dissection; mortality