title: [DEVELOPMENT OF CELL SHEET ENGINEERING TECHNOLOGY IN ENGINEERING VASCULARIZED TISSUE].
abstract: OBJECTIVE
  To review the development of cell sheet engineering technology in engineering vascularized tissue.
  
  
  METHODS
  The literature about cell sheet engineering technology and engineering vascularized tissue was reviewed, analyzed, and summarized.
  
  
  RESULTS
  Although there are many methods to engineer vascularized tissue, cell sheet engineering technology provides a promising potential to develop a vascularized tissue. Recently, cell sheet engineering technology has become a hot topic in engineering vascularized tissue. Co-culturing endothelial cells on a cell sheet, endothelial cells are able to form three-dimensional prevascularized networks and microvascular cavities in the cell sheet, which facilitate the formation of functional vascular networks in the transplanted tissue.
  
  
  CONCLUSIONS
  Cell sheet engineering technology is a promising strategy to engineer vascularized tissue, which is still being studied to explore more potential.
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.forename: Dongyang
authors.initials: D
authors.lastname: Ma
authors.forename: Liling
authors.initials: L
authors.lastname: Ren
mesh_terms: D018929:Cell Culture Techniques / Q000379:methods*; D042783:Endothelial Cells / Q000166:cytology*; D006801:Humans; D018919:Neovascularization, Physiologic; D023822:Tissue Engineering / Q000379:methods*