title: Matrix solid-phase dispersion coupled with homogeneous ionic liquid microextraction for the determination of sulfonamides in animal tissues using high-performance liquid chromatography.
abstract: Matrix solid-phase dispersion coupled with homogeneous ionic liquid microextraction was developed and applied to the extraction of some sulfonamides, including sulfamerazine, sulfamethazine, sulfathiazole, sulfachloropyridazine, sulfadoxine, sulfisoxazole, and sulfaphenazole, in animal tissues. High-performance liquid chromatography was applied to the separation and determination of the target analytes. The solid sample was directly treated by matrix solid-phase dispersion and the eluate obtained was treated by homogeneous ionic liquid microextraction. The ionic liquid was used as the extraction solvent in this method, which may result in the improvement of the recoveries of the target analytes. To avoid using organic solvent and reduce environmental pollution, water was used as the elution solvent of matrix solid-phase dispersion. The effects of the experimental parameters on recoveries, including the type and volume of ionic liquid, type of dispersant, ratio of sample to dispersant, pH value of elution solvent, volume of elution solvent, amount of salt in eluate, amount of ion-pairing agent (NH4 PF6 ), and centrifuging time, were evaluated. When the present method was applied to the analysis of animal tissues, the recoveries of the analytes ranged from 85.4 to 118.0%, and the relative standard deviations were lower than 9.30%. The detection limits for the analytes were 4.3-13.4 μg/kg.
authors.affiliation: College of Chemistry and Life Science, Changchun University of Technology, Changchun, P.R. China.|College of Chemistry, Jilin University, Changchun, P.R. China.
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Wang
authors.affiliation: College of Chemistry and Life Science, Changchun University of Technology, Changchun, P.R. China.
authors.forename: Mengyu
authors.initials: M
authors.lastname: He
authors.affiliation: College of Chemistry and Life Science, Changchun University of Technology, Changchun, P.R. China.|College of Chemistry, Jilin University, Changchun, P.R. China.
authors.forename: Chunzhu
authors.initials: C
authors.lastname: Jiang
authors.affiliation: College of Chemistry and Life Science, Changchun University of Technology, Changchun, P.R. China.
authors.forename: Fengqing
authors.initials: F
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Life Science, Changchun University of Technology, Changchun, P.R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Du
authors.affiliation: College of Chemistry and Life Science, Changchun University of Technology, Changchun, P.R. China.
authors.forename: Wennan
authors.initials: W
authors.lastname: Feng
authors.affiliation: College of Chemistry, Jilin University, Changchun, P.R. China.
authors.forename: Hanqi
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002623:Chemistry Techniques, Analytical; D002851:Chromatography, High Pressure Liquid; D052578:Ionic Liquids / Q000737:chemistry*; D007668:Kidney / Q000737:chemistry; D057230:Limit of Detection; D059627:Liquid Phase Microextraction; D008099:Liver / Q000737:chemistry; D015394:Molecular Structure; D009132:Muscles / Q000737:chemistry; D013449:Sulfonamides / Q000032:analysis*
chemical_list: D052578:Ionic Liquids; D013449:Sulfonamides
keywords: High-performance liquid chromatography; Homogeneous ionic liquid microextraction; Ionic liquids; Matrix solid-phase dispersion; Sulfonamides