title: Weekly cisplatin and radiotherapy for low risk, locoregionally advanced human papillomavirus-positive oropharyngeal squamous cell carcinoma.
abstract: There is interest in different treatment strategies, including deintensification in good prognosis human papillomavirus-positive (HPV(+)) oropharyngeal squamous cell carcinoma (SCC). We reviewed our experience with weekly cisplatin in low-risk, locoregionally advanced HPV(+) oropharyngeal SCC since late 2009.
  
  
  
  Data from patients with low-risk HPV(+) oropharyngeal SCC treated with weekly cisplatin (40 mg/m(2) ) and 70 Gy radiotherapy were collected. Low risk was defined as stage III to IV oropharyngeal SCC excluding T1-2N1, T4 or N3 disease, or N2b to N2c disease in patients with >10 pack-year smoking history.
  
  
  
  Of 31 patients, the median age was 56 years (range, 41-69 years). All patients completed 70 Gy radiotherapy within 51 days and 84% completed at least 5 cycles of cisplatin. Grade 3 mucositis occurred in 22 patients (71%) and grade 3 febrile neutropenia in 6 patients (19%). No patients required enteral feeding at 12 months. The median follow-up was 30 months (range, 21-57 months) with no recurrences or deaths.
  
  
  
  Concurrent weekly cisplatin is relatively well-tolerated and associated with excellent disease control in low-risk, locoregionally advanced HPV(+) oropharyngeal SCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1117-E1121, 2016.
authors.affiliation: Department of Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
authors.forename: Damien
authors.initials: D
authors.lastname: Urban
authors.affiliation: Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.|University of Melbourne, Parkville, Australia.
authors.forename: June
authors.initials: J
authors.lastname: Corry
authors.affiliation: Department of Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.|University of Melbourne, Parkville, Australia.
authors.forename: Ben
authors.initials: B
authors.lastname: Solomon
authors.affiliation: Department of Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
authors.forename: Annette M
authors.initials: AM
authors.lastname: Lim
authors.affiliation: Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
authors.forename: Tsien
authors.initials: T
authors.lastname: Fua
authors.affiliation: Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Coleman
authors.affiliation: Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
authors.forename: Ieta
authors.initials: I
authors.lastname: D'Costa
authors.affiliation: Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
authors.forename: Albert
authors.initials: A
authors.lastname: Tiong
authors.affiliation: Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.|University of Melbourne, Parkville, Australia.
authors.forename: Lester J
authors.initials: LJ
authors.lastname: Peters
authors.affiliation: Department of Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.|University of Melbourne, Parkville, Australia.
authors.forename: Danny
authors.initials: D
authors.lastname: Rischin
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000628:therapy* / Q000821:virology; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009959:Oropharyngeal Neoplasms / Q000628:therapy* / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications*; D011878:Radiotherapy; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin
keywords: human papillomavirus (HPV); weekly cisplatin