title: Resveratrol decreases the insoluble Aβ1-42 level in hippocampus and protects the integrity of the blood-brain barrier in AD rats.
abstract: Our previous studies demonstrated resveratrol (Res) administration protected Alzheimer's disease (AD) rats from developing memory decline by anti-oxidation. Beta-amyloid peptide 1-42 (Aβ1-42) is not only the primary protein component of senile plaques in AD but also is believed to play an important part in its pathology. Increasing evidence has shown neuroinflammation and the integrity of the blood-brain barrier (BBB) is closely related to the pathogenesis of AD. The aim of the present study is to further elucidate whether Res prevents AD rats from inflammation induced by Aβ1-42 and protects the integrity of BBB. Rats were divided into six groups: (1) ovariectomized (OVX)+D-galactose (D-gal) 100mg/kg group (OVX+D-gal); (2-4) OVX, D-gal and Res 20, 40 and 80 mg/kg treated groups; and (5) OVX, D-gal and estradiol valerate 0.8 mg/kg treated group (ET); (6) Sham control group. 12 weeks later, Res 40 and 80 mg/kg treatment exhibited a significant decrease of Aβ1-42 compared with the OVX+D-gal rats of hippocampus, which was accompanied by decreased expression of advanced glycation endproducts (RAGE), matrix metalloprotein-9 (MMP-9), nuclear factor kappaB (NF-κB) and the increase of Claudin-5. These results suggest that Res is useful not only in protecting OVX+D-gal rats from neuroinflammation mediated by Aβ1-42 by decreasing the expression of NF-κB but also the integrity of BBB by increasing Claudin-5 and decreasing RAGE, MMP-9.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China. Electronic address: haifengzao75@163.com.
authors.forename: H F
authors.initials: HF
authors.lastname: Zhao
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: N
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Cheng
authors.affiliation: Center for Disease Control and Prevention in Shanxi Province, Taiyuan, Shanxi 030012, PR China.
authors.forename: X M
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
authors.forename: T T
authors.initials: TT
authors.lastname: Liu
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000378:metabolism*; D062507:Claudin-5 / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005690:Galactose; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D010052:Ovariectomy; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*; D051996:Transcription Factor RelA / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D062507:Claudin-5; C491510:Cldn5 protein, rat; D017127:Glycation End Products, Advanced; D010446:Peptide Fragments; D013267:Stilbenes; D051996:Transcription Factor RelA; C075222:amyloid beta-protein (1-42); D020780:Matrix Metalloproteinase 9; D000077185:Resveratrol; D005690:Galactose
keywords: Claudin-5; beta-amyloid peptide 1–42; matrix metalloprotein-9; nuclear factor kappaB; receptor for advanced glycation endproducts; resveratrol