title: Reduction of Cerebral Edema via an Osmotic Transport Device Improves Functional Outcome after Traumatic Brain Injury in Mice.
abstract: Traumatic brain injury (TBI), the foremost cause of morbidity and mortality in persons under 45 years of age worldwide, leads to about 200,000 victims requiring hospitalization and approximately 52,000 deaths per year in the United States. TBI is characterized by cerebral edema leading to raised intracranial pressure, brain herniation, and subsequent death. Current therapies for TBI treatment are often ineffective, thus novel therapies are needed. Recent studies have shown that an osmotic transport device (OTD) is capable of reducing brain water content and improving survival in mice with severe cerebral edema. Here we compare the effects of a craniectomy and an OTD plus craniectomy on neurological function in mice after TBI. Animals treated with a craniectomy plus an OTD had significantly better neurological function 2 days after TBI compared with those treated with craniectomy only. This study suggests that an OTD for severe brain swelling may improve patient functional outcome. Future studies include a more comprehensive neurological examination, including long-term memory tests.
authors.affiliation: Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Devin W
authors.initials: DW
authors.lastname: McBride
authors.affiliation: Cell, Molecular and Developmental Biology Program, University of California, Riverside, CA, USA.
authors.forename: Virginia
authors.initials: V
authors.lastname: Donovan
authors.affiliation: Division of Biomedical Sciences, School of Medicine, University of California, 1247 Webber Hall, Riverside, CA, 92521, USA.
authors.forename: Mike S
authors.initials: MS
authors.lastname: Hsu
authors.affiliation: Cell, Molecular and Developmental Biology Program, University of California, Riverside, CA, USA.|Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Andre
authors.initials: A
authors.lastname: Obenaus
authors.affiliation: Department of Bioengineering, University of California, Riverside, CA, USA.
authors.forename: V G J
authors.initials: VG
authors.lastname: Rodgers
authors.affiliation: Division of Biomedical Sciences, School of Medicine, University of California, 1247 Webber Hall, Riverside, CA, 92521, USA. dbinder@ucr.edu.
authors.forename: Devin K
authors.initials: DK
authors.lastname: Binder
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001929:Brain Edema / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D000070642:Brain Injuries, Traumatic / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D056424:Decompressive Craniectomy; D004195:Disease Models, Animal; D004864:Equipment and Supplies; D005260:Female; D051379:Mice; D009995:Osmosis
keywords: Brain edema; Brain swelling; OTD; Osmotic transport device; TBI; Traumatic brain injury