title: Dynamics of Blood Pressure Elevation and Endothelial Dysfunction in SHR Rats During the Development of Arterial Hypertension.
abstract: The dynamics of systolic and diastolic BP and vasodilatory activity of the endothelium in SHR and Wistar-Kyoto rats was studied from the 5th to the 12th week of life. Systolic and diastolic BP did not differ in 5-week-old SHR and Wistar-Kyoto rats. After the 6th week of life, two stages of arterial hypertension development were observed in SHR. Stage 1 (weeks 6-8) was characterized by a significant increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 26-32%. Vasodilatory activity of the endothelium was similar in rats of both strains at the age of 5-7 weeks. Stage 2 (weeks 9-12) in SHR rats was characterized by further increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 54-89%. The increase in BP during this period was accompanied by a significant decrease in endothelium-dependent relaxation (by 14-16% compared to that in Wistar-Kyoto rats of the same age).
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Anishchenko
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.|National Research Tomsk State University, Tomsk, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Aliev
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Sidekhmenova
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Shamanaev
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. mbp2001@mail.ru.|National Research Tomsk State University, Tomsk, Russia. mbp2001@mail.ru.
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
mesh_terms: D000818:Animals; D062186:Arterial Pressure; D003971:Diastole; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013599:Systole; D013997:Time Factors; D059289:Vascular Stiffness; D014664:Vasodilation
keywords: SHR rats; Wistar-Kyoto rats; arterial hypertension; blood pressure; endothelial Dysfunction