title: [NON-RESPIRATORY FUNCTION OF THE LUNGS IN THE NIGROSTRIATAL DOPAMINERGIC SYSTEM DYSFUNCTION].
abstract: The study presents a comprehensive of the metabolism and the fractional composition of li- pids surfactant, water balance, hemostatic activity of the lungs in neyrodegeneration substantia nigra of the brain induced by stereotaxic microinjection of 6--hydroxydopamine and systemic administration of haloperidol. It is shown that a breach of dopaminergic neurotransmission leads to deterioration of surface-active properties of the alveolar lining of the complex against a decrea- se of phospholipids, cholesterol, phosphatidylcholine and lysophospholipids enhance the pulmo- nary surfactant in the activation of phospholipase hydrolysis and lipid peroxidation. Intranigral introduction neurotoxin accompanied by increased blood supply to the lungs and the blood coagu- lation potential of the pulmonary circulation, the blockade D2-receptors--hyporhydration lung tissue. The results obtained indicate the formation of dysregulation pneumopathy dysfunction nigrostriatal dopaminergic system.
authors.forename: M R
authors.initials: MR
authors.lastname: Timofeeva
authors.forename: S A
authors.initials: SA
authors.lastname: Lukina
mesh_terms: D000818:Animals; D018492:Dopamine Antagonists / Q000009:adverse effects* / Q000494:pharmacology; D006220:Haloperidol / Q000009:adverse effects* / Q000494:pharmacology; D006892:Hydroxydopamines / Q000009:adverse effects* / Q000494:pharmacology; D008168:Lung / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051381:Rats; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D018492:Dopamine Antagonists; D006892:Hydroxydopamines; D006220:Haloperidol