title: High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer.
abstract: Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan-Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.
authors.affiliation: Cancer Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, 324 Jingwu Weiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Baoying
authors.initials: B
authors.lastname: Yuan
authors.affiliation: Department of Orthopedics, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, 324 Jingwu Weiqi Road, Jinan, Shandong, 250021, China.
authors.forename: Changshun
authors.initials: C
authors.lastname: Wu
authors.affiliation: Cancer Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, 324 Jingwu Weiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Xingwen
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Saha Cardiovascular Research Center, University of Kentucky College of Medicine, 741 S. Limestone Street, Lexington, KY, 40536, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Cancer Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, 324 Jingwu Weiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Central Lab, Shandong Provincial Hospital affiliated to Shandong University, 324 Jingwu Weiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Pediatrics, Saha Cardiovascular Research Center, University of Kentucky College of Medicine, 741 S. Limestone Street, Lexington, KY, 40536, USA. 18753157528@163.com.
authors.forename: Xiang-An
authors.initials: XA
authors.lastname: Li
authors.affiliation: Cancer Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, 324 Jingwu Weiqi Road, Jinan, Shandong, 250021, People's Republic of China. junqinghan1@126.com.
authors.forename: Junqing
authors.initials: J
authors.lastname: Han
authors.affiliation: Cancer Center, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, 324 Jingwu Weiqi Road, Jinan, Shandong, 250021, People's Republic of China. hongfeng1268@126.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Feng
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D051122:Scavenger Receptors, Class B / Q000096:biosynthesis*; D046888:Tissue Array Analysis / Q000379:methods / Q000706:statistics & numerical data; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D051122:Scavenger Receptors, Class B; C495124:SCARB1 protein, human
keywords: Breast cancer; Immunohistochemistry; Prognosis; Scavenger receptor class B type I