title: Increased serum urea and creatinine levels correlate with decreased retinal nerve fibre layer thickness in diabetic retinopathy.
abstract: Correlation of increased levels of serum urea and creatinine with retinal nerve fibre layer (RNFL) thinning on spectral domain optical coherence tomography (SD-OCT) was studied in diabetic retinopathy (DR). Sixty consecutive cases and 20 healthy controls were included. Cases were divided into three groups: without DR, non-proliferative DR with macular oedema and proliferative DR with oedema. Serum urea and creatinine were measured using a standard protocol. Average (RNFL) was measured using SD-OCT. Increased severity of DR was associated with decrease in levels of serum urea and serum creatinine levels. RNFL thinning correlated positively with increase in serum urea and creatinine levels.
authors.affiliation: a Retina Service, Department of Ophthalmology and.
authors.forename: Khushboo
authors.initials: K
authors.lastname: Srivastav
authors.affiliation: a Retina Service, Department of Ophthalmology and.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Saxena
authors.affiliation: b Department of Biochemistry , King George's Medical University , Lucknow , India .
authors.forename: Abbas A
authors.initials: AA
authors.lastname: Mahdi
authors.affiliation: c International Clinical Research Center, St. Anne's University Hospital and Masaryk University , Brno , Czech Republic , and.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
authors.affiliation: d Indian Institute of Toxicology and Research , Lucknow , India.
authors.forename: Vinay K
authors.initials: VK
authors.lastname: Khanna
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012160:Retina / Q000473:pathology*; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence; D014508:Urea / Q000097:blood*
chemical_list: D014508:Urea; D003404:Creatinine
keywords: Creatinine; diabetic nephropathy; diabetic retinopathy; retinal nerve fibre layer thickness; urea