title: Diterpenoids from the twigs and leaves of Croton caudatus var. tomentosus.
abstract: One new 9,10-seco-abietane derivative, crotontomentosin A (1), four new abietane-type diterpenoids, crotontomentosins B-E (2-5), one new ent-halimane-type diterpenoid, crotontomentosin F (6), along with five known diterpenoids (7-11) and one known sesquiterpenoid (12) were obtained from the twigs and leaves of Croton caudatus Geisel. var. tomentosus Hook. The structures of the compounds were established on the basis of extensive spectroscopic data. Compounds 1-4 and 11 exhibited moderate to weak inhibitory activity against the proliferation of the Hela, Hep G2, MDA-MB-231, or A549 cell lines selectively.
authors.affiliation: Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
authors.forename: Jin-Tong
authors.initials: JT
authors.lastname: Song
authors.affiliation: Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.affiliation: The Second Hospital of Shandong University, 247 Bei-Yuan Street, Jinan 250033, PR China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.affiliation: Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
authors.affiliation: Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China. Electronic address: wangxn@sdu.edu.cn.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts
keywords: 15-hydroxy-7-oxoabieta-8,11,13-triene (PubChem CID: 128740); 5-epi-eudesm-4(15)-ene-1β,6β-diol (PubChem CID: 11746695); Abietane; Cisplatin (PubChem CID: 5702198); Croton caudatus var. tomentosus; Cytotoxicity; Diterpenoid; Doxorubicin (PubChem CID: 31703); Margocin (PubChem CID: 21632833); ent-15,16-epoxyhalim-5(10),13(16),14-trien-18-carboxylic acid (PubChem CID: 11404306); ent-Halimane