title: Animal models of tumorigenic herpesviruses--an update.
abstract: Any one model system, be it culture or animal, only recapitulates one aspect of the viral life cycle in the human host. By providing recent examples of animal models for Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus, we would argue that multiple animal models are needed to gain a comprehensive understanding of the pathogenesis associated with human oncogenic herpesviruses. Transgenic mice, homologous animal herpesviruses, and tumorgraft and humanized mouse models all complement each other in the study of viral pathogenesis. The use of animal model systems facilitates the exploration of novel anti-viral and anti-cancer treatment modalities for diseases associated with oncogenic herpesviruses.
authors.affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina, Chapel Hill, USA. Electronic address: ddittmer@med.unc.edu.
authors.forename: Dirk P
authors.initials: DP
authors.lastname: Dittmer
authors.affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina, Chapel Hill, USA.
authors.forename: Blossom
authors.initials: B
authors.lastname: Damania
authors.affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina, Chapel Hill, USA.
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Sin
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D004195:Disease Models, Animal; D006564:Herpesviridae / Q000502:physiology*; D006566:Herpesviridae Infections / Q000473:pathology* / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D051379:Mice; D009858:Oncogenic Viruses / Q000502:physiology*