title: Mangosteen Extract Attenuates the Metabolic Disorders of High-Fat-Fed Mice by Activating AMPK.
abstract: This study investigated the effects of mangosteen on metabolic syndromes in high-fat (HF) diet-fed mice and the underlying mechanisms related to adipogenesis. Mangosteen-supplemented mice gained significantly less body weight, compared with the HF group. The levels were markedly elevated in HF mice for serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, glucose, triglyceride, total cholesterol, low-density lipoprotein (LDL) cholesterol, and free fatty acid; whereas these levels were significantly lower in the 200 mg/kg of the mangosteen extract-treated group. The mangosteen extract did not modify high-density lipoprotein (HDL)-cholesterol, however, LDL-cholesterol was lower and HDL/LDL ratio was higher (9.4 vs. 3.7 in HF group). Furthermore, 200 mg/kg of mangosteen treatment activated the hepatic AMP-activated protein kinase and Sirtuin 1 in an in vivo system. Thus, the results of this study suggest that mangosteen extract exerts antiobesity effects by regulating energy metabolism and hepatic lipid homeostasis.
authors.affiliation: 1 College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , Gyeonggido, Korea.
authors.forename: Hee-Sung
authors.initials: HS
authors.lastname: Chae
authors.affiliation: 1 College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , Gyeonggido, Korea.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Kim
authors.affiliation: 1 College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , Gyeonggido, Korea.
authors.forename: Jin-Kyung
authors.initials: JK
authors.lastname: Bae
authors.affiliation: 1 College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , Gyeonggido, Korea.
authors.forename: Sochivak
authors.initials: S
authors.lastname: Sorchhann
authors.affiliation: 1 College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , Gyeonggido, Korea.
authors.forename: Sreymom
authors.initials: S
authors.lastname: Yim
authors.affiliation: 1 College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , Gyeonggido, Korea.
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.affiliation: 2 International Biological Material Research Centre, Korea Research Institute of Bioscience and Biotechnology , Daejeon, Korea.
authors.forename: Jin Hyub
authors.initials: JH
authors.lastname: Paik
authors.affiliation: 1 College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , Gyeonggido, Korea.
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Choi
authors.affiliation: 1 College of Pharmacy and BK21Plus R-Find Team, Dongguk University-Seoul , Gyeonggido, Korea.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D050156:Adipogenesis / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D004734:Energy Metabolism / Q000187:drug effects; D029762:Garcinia mangostana / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008659:Metabolic Diseases / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology*; D056564:Sirtuin 1 / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D019440:Anti-Obesity Agents; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D010936:Plant Extracts; D014280:Triglycerides; D001219:Aspartate Aminotransferases; D055372:AMP-Activated Protein Kinases; D056564:Sirtuin 1
keywords: AMP-activated protein kinase; Garcinia mangostana; Sirtuin 1; antiobesity