title: Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke.
abstract: Recent genome-wide association studies (GWAS) have identified genetic variants associated with coronary artery disease (CAD), ischemic stroke (IS) and serum lipid traits in different ethnic groups. Some loci were found to affect the risk of CAD and IS. However, there were no data in the southern Chinese populations. Our study was to assess the association of CELSR2-PSRC1-SORT1 rs599839, rs464218 and rs6698443 SNPs and serum lipid levels and the risk of CAD and IS. The genotypes of 3 SNPs were detected in 561 CAD and 527 IS patients, and in 590 healthy controls. The genotypic and allelic frequencies of the rs599839 SNP were different between the controls and IS patients (P < 0.05). The minor G alleles of rs599839 and rs464218 SNPs were associated with higher high-density lipoprotein cholesterol concentrations in CAD and IS patients (P < 0.05); respectively. No association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2-PSRC1-SORT1 and the risk of CAD or IS. These results will be replicated in the other Chinese populations.
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Yi-Jiang
authors.initials: YJ
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, Guangxi Provincial Corps Hospital, Chinese People's Armed Police Forces China.
authors.forename: Shao-Cai
authors.initials: SC
authors.lastname: Hong
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Cao
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Wu-Xian
authors.initials: WX
authors.lastname: Chen
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D015820:Cadherins / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*; D000099183:Sortilin
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D015820:Cadherins; D008055:Lipids; D010750:Phosphoproteins; D000099183:Sortilin; C498477:CELSR2 protein, human; C485740:PSRC1 protein, human
keywords: CELSR2: cadherin EGF LAG seven-pass G-type receptor 2; PSRC1: proline/serine-rich coiled-coil 1; SORT1: sortilin; coronary artery disease; ischemic stroke; serum lipid traits