title: The feasibility of the ACOSOG Z0011 Criteria to Chinese Breast Cancer Patients: A Multicenter Study.
abstract: The aim of this study was to determine the feasibility of the Z0011 criteria to Chinese breast cancer patients. An survey about the Z0011 trial was distributed and we collected 658 consecutive patients with axillary lymph node dissection (ALND) after positive sentinel lymph node (SLN) biopsy from five centers' databases and grouped them as eligible or ineligible for omitting ALND according to the Z0011 criteria. The eligible group was compared with the cohort included in the Z0011 trial and with the ineligible group. Of the 427 respondants, 106 (24.8%) and 130 (30.4%)would not routinely perform ALND in patients meeting Z0011 criteria before and after learning of the trial results, respectively. Among the 658 patients, 151 (22.9%) were eligible and 507 were ineligible for omitting ALND. The clinicopathologic factors were not statistically different between the eligible group and the Z0011 cohort. Compared with the eligible Group, the ineligible group had significantly more T2 and T3 stage tumors, positive lymph nodes(LNs) and positive non-sentinel lymph nodes (NSLNs) (P < 0.01). The findings suggest good exportability of the Z0011 criteria to Chinese patients omitting ALND, but application of Z0011 as national treatment guideline still needs additional time and effort.
authors.affiliation: Breast Center, Peking University People's Hospital, Beijing, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Liu
authors.affiliation: Breast Center, Peking University People's Hospital, Beijing, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Breast Surgery, Cancer Center of Henan Province, China.
authors.forename: Shude
authors.initials: S
authors.lastname: Cui
authors.affiliation: Breast Disease's Center, The first Affiliated Hospital of Peking University, China.
authors.forename: Xuening
authors.initials: X
authors.lastname: Duan
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of Jilin Univesity, China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Department of Breast Surgery, The Second Affiliated Hospital of Shandong University, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002681:China; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D021701:Sentinel Lymph Node Biopsy; D011795:Surveys and Questionnaires