title: [Apoptosis modulation by human papillomavirus].
abstract: One of the most important processes to keep the homeostasis in organisms is the apoptosis, also called programmed cell death. This mechanism works through two pathways: The intrinsic or mitochondrial, which responds to DNA damage and extern agents like UV radiation; and the extrinsic or receptor-mediated, which binds to their ligands to initiate the apoptotic trail. The evasion of apoptosis is one of the main causes of cellular transformation to malignity. Many viruses had shown capacity to modify the apoptotic process; among them is the human papillomavirus, which, by means of its oncoproteins, interferes in pathways, reacting with the receptors and molecules and participating in the death mechanism. This creates ideal conditions for cancer development.
authors.affiliation: División de Inmunología, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. lfjave@yahoo.com.
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Jave-Suárez
authors.forename: Sarah
authors.initials: S
authors.lastname: Ratkovich-González
authors.forename: Vicente
authors.initials: V
authors.lastname: Olimón-Andalón
authors.forename: Adriana
authors.initials: A
authors.lastname: Aguilar-Lemarroy
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000378:metabolism; D027383:Papillomaviridae / Q000378:metabolism / Q000472:pathogenicity*; D050725:Papillomavirus E7 Proteins / Q000378:metabolism; D030361:Papillomavirus Infections / Q000503:physiopathology / Q000821:virology*; D012097:Repressor Proteins / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000503:physiopathology / Q000821:virology*; D000086082:Viroporin Proteins
chemical_list: D015415:Biomarkers; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C068651:E6 protein, Human papillomavirus type 16; C054859:oncogene protein E5, Human papillomavirus type 16; D000086082:Viroporin Proteins
keywords: Apoptosis; Human papillomavirus; Uterine cervical neoplasms