title: Propofol effects on cerebellar long-term depression.
abstract: Propofol is an intravenously administered anesthetic that induces γ-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning.
authors.affiliation: Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Electronic address: lky@life.illinois.edu.
authors.forename: Kwan Young
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea; Department of Anesthesiology, Yeosu Chonnam Hospital, Yeosu, South Korea. Electronic address: thinker96@hanmail.net.
authors.forename: Young Im
authors.initials: YI
authors.lastname: Kim
authors.affiliation: Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea. Electronic address: sehkim@konyang.ac.kr.
authors.forename: Se Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea. Electronic address: hspark@konyang.ac.kr.
authors.forename: Hyung Seo
authors.initials: HS
authors.lastname: Park
authors.affiliation: Department of Pediatric Surgery, Dankook University, College of Medicine, Cheonan, South Korea. Electronic address: psurgeon@naver.com.
authors.forename: Youn Joon
authors.initials: YJ
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, Konyang University Hospital, Daejeon, South Korea; Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon, South Korea. Electronic address: hmseye@hanmail.net.
authors.forename: Myung Sook
authors.initials: MS
authors.lastname: Ha
authors.affiliation: Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. Electronic address: yjin4@jhmi.edu.
authors.forename: Yunju
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea; Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon, South Korea. Electronic address: 92dodong@gmail.com.
authors.forename: Dong Kwan
authors.initials: DK
authors.lastname: Kim
mesh_terms: D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D036881:Long-Term Synaptic Depression / Q000187:drug effects*; D015742:Propofol / Q000494:pharmacology*; D011689:Purkinje Cells / Q000187:drug effects / Q000502:physiology; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism
chemical_list: D018686:Anesthetics, Intravenous; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; D015742:Propofol
keywords: Cerebellum; Long-term depression; Metabotropic glutamate receptor 1; Parallel fiber; Propofol; Purkinje cell