title: Mitochondrial DNA Haplogroup R Confers a Genetic Risk Factor for Intrauterine Adhesion in Han Women Population.
abstract: BACKGROUND
  To determine whether a specific mitochondrial DNA (mtDNA) haplogroup is implicated in the pathogenesis of intrauterine adhesion (IUA).
  
  
  METHODS
  Peripheral blood samples were collected from 486 women with (case group, n = 154) and without IUA (control group, n = 332) at the Women's Hospital, Zhejiang University School of Medicine. Genomic DNA was extracted from the blood, and the mtDNA haplogroups of Han women M, N and R were determined by sequencing hypervariable mtDNA segments and testing diagnostic polymorphisms in the mtDNA coding region.
  
  
  RESULTS
  Women with mtDNA haplogroup R had an independently increased genetic risk factor for IUA with an OR 1.77 (95% CI 1.16-2.70, p = 0.009) compared with women without. Moreover, repeated intrauterine surgery within 1 month and number of intrauterine operations were both significantly associated with IUA (p < 0.001).
  
  
  CONCLUSIONS
  These results suggest that mtDNA haplogroup R, one of the main mtDNA haplogroups in Han population, is a strong independent genetic risk factor for women with IUA.
authors.affiliation: Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Libo
authors.initials: L
authors.lastname: Zhu
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Huang
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.forename: Zhengyun
authors.initials: Z
authors.lastname: Chen
authors.forename: Qiongshi
authors.initials: Q
authors.lastname: Huang
authors.forename: Xinmei
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications; D011247:Pregnancy; D000267:Tissue Adhesions / Q000209:etiology / Q000235:genetics*; D014591:Uterine Diseases / Q000209:etiology / Q000235:genetics*; D014599:Uterus / Q000601:surgery
chemical_list: D004272:DNA, Mitochondrial