title: Domino intramolecular Diels-Alder reactions to construct a 6/6/5/5 fused tetracyclic framework.
abstract: Domino intramolecular Diels-Alder (IMDA) reactions towards the 6/6/5/5 fused tetracyclic natural products were developed in satisfactory yield and high stereoselectivity. Four rings, six contiguous stereocenters and four C-C bonds were formed in a single operation. 4-epi-Hydromitchellene B was also synthesised efficiently via this strategy.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, China. shexg@lzu.edu.cn.
authors.forename: Gaoyuan
authors.initials: G
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, China. shexg@lzu.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, China. shexg@lzu.edu.cn.
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, China. shexg@lzu.edu.cn.
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Duan
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, China. shexg@lzu.edu.cn.
authors.forename: Ziyun
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, China. shexg@lzu.edu.cn.
authors.forename: Xingang
authors.initials: X
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, China. shexg@lzu.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 30071, China.
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D061565:Cycloaddition Reaction
chemical_list: D001688:Biological Products