title: Fluorescent nanoparticles based on AIE fluorogens for bioimaging.
abstract: Fluorescent nanoparticles (FNPs) have recently attracted increasing attention in the biomedical field because of their unique optical properties, easy fabrication and outstanding performance in imaging. Compared with conventional molecular probes including small organic dyes and fluorescent proteins, FNPs based on aggregation-induced emission (AIE) fluorogens have shown significant advantages in tunable emission and brightness, good biocompatibility, superb photo- and physical stability, potential biodegradability and facile surface functionalization. In this review, we summarize the latest advances in the development of fluorescent nanoparticles based on AIE fluorogens including polymer nanoparticles and silica nanoparticles over the past few years, and the various biomedical applications based on these fluorescent nanoparticles are also elaborated.
authors.affiliation: State Key Lab of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China. xubin@jlu.edu.cn wjtian@jlu.edu.cn.
authors.forename: Lulin
authors.initials: L
authors.lastname: Yan
authors.affiliation: State Key Lab of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China. xubin@jlu.edu.cn wjtian@jlu.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Lab of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China. xubin@jlu.edu.cn wjtian@jlu.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.affiliation: State Key Lab of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China. xubin@jlu.edu.cn wjtian@jlu.edu.cn.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Tian
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008164:Luminescent Proteins / Q000737:chemistry / Q000378:metabolism; D008856:Microscopy, Fluorescence; D015335:Molecular Probes / Q000737:chemistry / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D009369:Neoplasms / Q000000981:diagnostic imaging; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared
chemical_list: D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D008164:Luminescent Proteins; D015335:Molecular Probes; D011108:Polymers; D012822:Silicon Dioxide