title: Efficacy of High-Dose Baclofen for Alcohol Use Disorder and Comorbid Bulimia: A Case Report.
abstract: High-dose baclofen is a promising treatment for alcohol use disorder, with a specific action on craving. A more general action on craving in other addictive disorders has been suggested based on the hypothesis of a common neurobiological pathway in addictions. We report the case of a woman with both alcohol use disorder and bulimia nervosa. There was a positive response to high-dose baclofen on alcohol craving, but no response on food craving. The case illustrates that craving could be differentially responsive to anti-craving drugs.
authors.affiliation: a Department of Psychiatry and Mental Health , Strasbourg University Hospital , Strasbourg , France.|b INSERM Unit 1114 , Strasbourg , France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Weibel
authors.affiliation: a Department of Psychiatry and Mental Health , Strasbourg University Hospital , Strasbourg , France.|b INSERM Unit 1114 , Strasbourg , France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Lalanne
authors.affiliation: a Department of Psychiatry and Mental Health , Strasbourg University Hospital , Strasbourg , France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Riegert
authors.affiliation: a Department of Psychiatry and Mental Health , Strasbourg University Hospital , Strasbourg , France.|b INSERM Unit 1114 , Strasbourg , France.|c Translational Medicine Federation, Medical School, Strasbourg University , Strasbourg , France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Bertschy
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000188:drug therapy*; D001418:Baclofen / Q000627:therapeutic use*; D052018:Bulimia Nervosa / Q000150:complications / Q000188:drug therapy*; D066249:Craving; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D006801:Humans; D016896:Treatment Outcome
chemical_list: D001418:Baclofen
keywords: addiction; alcohol; baclofen; bulimia; craving; drug