title: Combined prognostic value of absolute lymphocyte/monocyte ratio in peripheral blood and interim PET/CT results in Hodgkin lymphoma.
abstract: Decreased absolute lymphocyte/monocyte ratio (LMR) in peripheral blood has been reported as an unfavorable prognostic marker in Hodgkin lymphoma. We aimed to investigate whether combining LMR and interim PET/CT scan result (PET2) confers stronger prognostic value than PET2 alone. 121 HL patients were investigated. LMR was calculated from a blood sample taken at the time of diagnosis. PET2 was carried out after the second chemotherapy cycle. Survival was calculated using the Kaplan-Meier method and significance was determined by log-rank test. Effect of variants on survival results was examined using univariate and multivariate analyses. Best LMR cut-off value was determined by receiver operating characteristic (ROC) curve. Best LMR cut-off value was 2.11 in the case of our patients (LMR > 2.11: favorable, LMR ≤ 2.11: unfavorable). Overall and progression-free survivals (OS/PFS) were significantly worse both in lower LMR (≤ 2.11) (OS: P = 0.041, PFS: P = 0.044) and PET2 positive groups (OS: P < 0.001, PFS: P < 0.001). In PET2 positive patient group (n = 32) the low LMR result meant a significantly worse OS (0.030) and PFS (0.001). Both LMR and PET2 proved to be independent prognostic factors on multivariate analysis, and strengthened each other's effect.
authors.forename: Zsofia
authors.initials: Z
authors.lastname: Simon
authors.forename: S
authors.initials: S
authors.lastname: Barna
authors.forename: Z
authors.initials: Z
authors.lastname: Miltenyi
authors.forename: K
authors.initials: K
authors.lastname: Husi
authors.forename: F
authors.initials: F
authors.lastname: Magyari
authors.forename: A
authors.initials: A
authors.lastname: Jona
authors.forename: I
authors.initials: I
authors.lastname: Garai
authors.forename: Z
authors.initials: Z
authors.lastname: Nagy
authors.forename: G
authors.initials: G
authors.lastname: Ujj
authors.forename: L
authors.initials: L
authors.lastname: Szerafin
authors.forename: A
authors.initials: A
authors.lastname: Illes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D000072078:Positron Emission Tomography Computed Tomography; D011379:Prognosis; D055815:Young Adult