title: A double-edged sword: CRISPR-Cas9 is emerging as a revolutionary technique for genome editing.
abstract: In May 2015, Professor Xiao Yang authored a review on the development of CRISPR-Cas9 techniques in the journal of Military Medical Research. This review provided a valuable overview of this major scientific advance. It has been four years since the first publication of the CRISPR-Cas9 breakthrough (Science. 2012; 337: 816-21). The use of this technique has expanded into various scientific areas and is being developed into a systematic technical platform that may contribute to many bioengineering fields involving DNA sequence editing.
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 200021 China.
authors.forename: Chun-Xiao
authors.initials: CX
authors.lastname: Li
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 200021 China.
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Qian
keywords: CRISPR-Cas9; Ethical controversy; Genomic engineering