title: POEMS syndrome associated with plasmacytoma of the clivus: "Time discovers the truth".
abstract: Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndrome is characterized by the presence of a monoclonal plasma cell disorder, peripheral neuropathy, and one or more of the following features: Osteosclerotic myeloma, Castleman's disease (angiofollicular lymph node hyperplasia), increased levels of serum vascular endothelial growth factor (VEGF), organomegaly, endocrinopathy, edema, typical skin changes, and papilledema. [1] Solitary plasmacytomas most frequently occur in the bone but can also be found in soft tissues (extramedullary plasmacytoma). [2] We report a case that showed a rare association of POEMS syndrome with a plasmacytoma of the clivus.
authors.affiliation: Department of Rheumatology, Lourdes Hospital, Kochi, Kerala, India.
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.affiliation: Department of Neurology, Lourdes Hospital, Kochi, Kerala, India.
authors.forename: B V
authors.initials: BV
authors.lastname: Maramattom
authors.affiliation: Department of Pathology, Lourdes Hospital, Kochi, Kerala, India.
authors.forename: J
authors.initials: J
authors.lastname: Varghese
authors.affiliation: Department of Pathology, Lourdes Hospital, Kochi, Kerala, India.
authors.forename: P M
authors.initials: PM
authors.lastname: Kuruvilla
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D003388:Cranial Fossa, Posterior / Q000000981:diagnostic imaging*; D006801:Humans; D008558:Melphalan / Q000627:therapeutic use; D016878:POEMS Syndrome / Q000000981:diagnostic imaging* / Q000628:therapy; D010954:Plasmacytoma / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D019292:Skull Base Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan; D011241:Prednisone