title: Carbohydrate-Conjugated Hollow Oblate Mesoporous Silica Nanoparticles as Nanoantibiotics to Target Mycobacteria.
abstract: Engineering nanomaterials with enhanced antibacterial activities remains a critical and practical challenge. Hollow oblate mesoporous silica nanoparticles (HOMSNs) are synthesized by a simple protocol of ammonia hydrothermal treatment of oblate mesoporous silica nanoparticles prepared using dibenzyl ether as a cosolvent. When conjugated with trehalose as the targeting ligand, the antibiotic-encapsulated HOMSNs exhibit high binding affinity and antibacterial efficacy toward mycobacteria.
authors.affiliation: Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
authors.forename: Nanjing
authors.initials: N
authors.lastname: Hao
authors.affiliation: Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
authors.forename: Xuan
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
authors.forename: Seaho
authors.initials: S
authors.lastname: Jeon
authors.affiliation: Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
authors.forename: Mingdi
authors.initials: M
authors.lastname: Yan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry*; D007538:Isoniazid / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009161:Mycobacterium / Q000187:drug effects* / Q000648:ultrastructure; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D012822:Silicon Dioxide / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D012822:Silicon Dioxide; D007538:Isoniazid
keywords: antimicrobial; mesoporous silica nanoparticles; nanoantibiotics; targeting; trehalose