title: Targeting tumor-stroma crosstalk: the example of the NT157 inhibitor.
abstract: Recent clinical research has provided evidence that cancer progression and therapy resistance is driven not only by tumor's genetic profile but also by complex paracrine interactions within the tumor microenvironment (TME). The role of TME in modulating tumor drug sensitivity is increasingly recognized and targeting TME has been the focus of novel therapeutic approaches. Two recent reports show that a new anti-cancer drug, the inhibitor NT157 has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.
authors.affiliation: School of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK.
authors.forename: T
authors.initials: T
authors.lastname: Rampias
authors.affiliation: Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK.
authors.forename: R
authors.initials: R
authors.lastname: Favicchio
authors.affiliation: Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Stebbing
authors.affiliation: School of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK.|Department of Surgery and Cancer, Imperial College, Hammersmith Hospital Campus, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Giamas
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D011748:Pyrogallol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D017154:Stromal Cells / Q000187:drug effects*; D013449:Sulfonamides / Q000494:pharmacology* / Q000627:therapeutic use; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; C000622270:NT157 compound; D013449:Sulfonamides; D011748:Pyrogallol