title: Nickel-Catalyzed Direct C (sp(3))-H Arylation of Aliphatic Amides with Thiophenes.
abstract: Nickel-catalyzed heteroarylation of the inactive methyl C(sp(3))-H bond of aliphatic amide with heteroarenes is described. The method takes advantage of chelation assistance by an 8-aminoquinolinyl moiety. The synthetic reaction has good tolerance toward functional groups, and it can be used in the construction of various kinds of alkyl-substituted heteroarenes.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha, 410082, P.R. China.
authors.forename: Xie
authors.initials: X
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha, 410082, P.R. China.
authors.forename: Longzhi
authors.initials: L
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha, 410082, P.R. China.
authors.forename: Sihai
authors.initials: S
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha, 410082, P.R. China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha, 410082, P.R. China.|Department of Chemistry, Hong Kong Baptist University , Hong Kong, P.R. China.
authors.forename: Chak-Tong
authors.initials: CT
authors.lastname: Au
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha, 410082, P.R. China.
authors.forename: Renhua
authors.initials: R
authors.lastname: Qiu