title: Recent advances of thermally responsive nanogels for cancer therapy.
abstract: Thermally responsive nanogel drug delivery systems (TRNDDS) have been widely investigated as a new strategy for active targeting tumor therapy, as these can accumulate on the tumor site and/or release the payload at the desired site by structure changes rapidly once stimulated by temperature changes. In this review, we discuss the evolution of TRNDDS and future perspectives for antitumor drug and gene delivery. With further understanding of the specificity of tumor site at the cellular and molecular level, in parallel with the development of nanomaterial design and preparation, TRNDDS show great potential for tumor targeting therapy.
authors.affiliation: Pharmacy Engineering Specialty, College of Chemistry & Chemical Engineering, GuangXi University, Nanning, China.|Department of Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of New Drug Screening, Drug Research Institute, Jiangsu CTTQ Pharmaceutical Company, Nanjing, China.
authors.forename: Hongjiang
authors.initials: H
authors.lastname: Xu
authors.affiliation: Pharmacy Engineering Specialty, College of Chemistry & Chemical Engineering, GuangXi University, Nanning, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D005782:Gels; D006358:Hot Temperature; D006801:Humans; D000080385:Nanogels; D049329:Nanostructures / Q000008:administration & dosage*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000378:metabolism; D011094:Polyethyleneimine / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D005782:Gels; D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine
keywords: hydrogel nanoparticles; nanogels; thermally responsive; tumor-targeted therapy