title: KO(t)Bu-Mediated Coupling of Indoles and [60]Fullerene: Transition-Metal-Free and General Synthesis of 1,2-(3-Indole)(hydro)[60]fullerenes.
abstract: Direct coupling of indoles with C60 has been achieved for the first time. Transition-metal-free KO(t)Bu-mediated reaction of indoles to [60]fullerene has been developed as a practical and efficient method for the synthesis of various 1,2-(3-indole)(hydro)[60]fullerenes that are otherwise difficult to direct synthesize in an efficient and selective manner. This methodology tolerates sensitive functionalities such as chloro, ester, and nitro on indole and builds molecular complexity rapidly, with most reactions reaching completion in <1 h. A plausible reaction mechanism is proposed to explain the high regioselectivity at the 3-position of the indoles and the formation of 1,2-(3-indole)(hydro)[60]fullerenes.
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Materials of Anhui Province, Anhui University , Hefei 230039, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Materials of Anhui Province, Anhui University , Hefei 230039, P.R. China.
authors.forename: Imad Elddin
authors.initials: IE
authors.lastname: Haj Elhussin
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Materials of Anhui Province, Anhui University , Hefei 230039, P.R. China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Materials of Anhui Province, Anhui University , Hefei 230039, P.R. China.
authors.forename: Hongping
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Materials of Anhui Province, Anhui University , Hefei 230039, P.R. China.
authors.forename: Jieying
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Chemistry, Key Laboratory of Functional Inorganic Materials of Anhui Province, Anhui University , Hefei 230039, P.R. China.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Tian