title: Regimens for the Hepatitis C Treatment-Naive Patient.
abstract: Hepatitis C virus (HCV) infection is a leading cause of cirrhosis and hepatocellular carcinoma, globally. Most individuals infected with HCV are asymptomatic. The introduction of the newer direct-acting antiviral (DAA) therapies has led to achievement of treatment success rates of more than 90%. Sustained virologic response is the end point of therapy, and is considered a virologic cure. It is defined as undetectable HCV RNA 12 weeks after end of therapy. This article reviews current approved non-interferon-based therapy and data from clinical trials in treatment-naive patients with chronic HCV infection.
authors.affiliation: Department of Gastroenterology, Cedars Sinai Medical Center, 8730 Alden Drive, Suite E235, Los Angeles, CA 90048, USA; Liver Transplant Program, Cedars Sinai Medical Center, 8900 Beverly Boulevard, Suite 250, Los Angeles, CA 90048, USA. Electronic address: Walid.Ayoub@cshs.org.
authors.forename: Walid S
authors.initials: WS
authors.lastname: Ayoub
authors.affiliation: Liver Transplant Program, Cedars Sinai Medical Center, 8900 Beverly Boulevard, Suite 250, Los Angeles, CA 90048, USA.
authors.forename: Tram T
authors.initials: TT
authors.lastname: Tran
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005838:Genotype; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D011480:Protease Inhibitors / Q000627:therapeutic use; D012367:RNA, Viral / Q000096:biosynthesis; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000998:Antiviral Agents; D019384:Nucleic Acid Synthesis Inhibitors; D011480:Protease Inhibitors; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase
keywords: Cirrhosis; DAA; Direct acting antivirals; Interferon-free; Treatment naive