title: Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.
abstract: BACKGROUND
  The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis.
  
  
  METHODS
  In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis.
  
  
  RESULTS
  We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29].
  
  
  CONCLUSIONS
  We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.
authors.affiliation: Institute of Rheumatology and Affine Sciences, Catholic University School of Medicine, Rome, Italy. f.biscetti@gmail.com.|Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy. f.biscetti@gmail.com.
authors.forename: Federico
authors.initials: F
authors.lastname: Biscetti
authors.affiliation: Department of Medicine, St M. Goretti Hospital, Latina, Italy. giuseppestraface@gmail.com.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Straface
authors.affiliation: Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy. carlofilippoporreca@gmail.com.|Department of Medicine, A. Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy. carlofilippoporreca@gmail.com.
authors.forename: Carlo Filippo
authors.initials: CF
authors.lastname: Porreca
authors.affiliation: Department of Vascular Surgery, St M. Goretti Hospital, Latina, Italy. gb.bertoletti@ausl.latina.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bertoletti
authors.affiliation: Department of Vascular Surgery, A. Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy. claudio.vincenzoni@rm.unicatt.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Vincenzoni
authors.affiliation: Department of Vascular Surgery, A. Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy. fsnider@rm.unicatt.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Snider
authors.affiliation: Department of Pathology, A. Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy. egidio.stigliano@rm.unicatt.it.
authors.forename: Egidio
authors.initials: E
authors.lastname: Stigliano
authors.affiliation: Department of Pathology, A. Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy. vincenzo.arena@rm.unicatt.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Arena
authors.affiliation: Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy. fangelini@hotmail.com.
authors.forename: Flavia
authors.initials: F
authors.lastname: Angelini
authors.affiliation: Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy. giovanni.pecorini@rm.unicatt.it.|Department of Medicine, A. Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy. giovanni.pecorini@rm.unicatt.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pecorini
authors.affiliation: Department of Endocrinology, A. Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy. antonio.bianchi@rm.unicatt.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Bianchi
authors.affiliation: Department of Medicine, A. Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy. rlandolfi@rm.unicatt.it.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Landolfi
authors.affiliation: Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy. andrea.flex@rm.unicatt.it.|Department of Medicine, A. Gemelli University Hospital, Catholic University School of Medicine, Rome, Italy. andrea.flex@rm.unicatt.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Flex
mesh_terms: D000368:Aged; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000601:surgery; D016893:Carotid Stenosis / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D016894:Endarterectomy, Carotid; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008297:Male; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D012189:Retrospective Studies; D018608:Ultrasonography, Doppler
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23