title: Paracetamol (acetaminophen) poisoning.
abstract: BACKGROUND
  Paracetamol directly causes around 150 deaths per year in UK.
  
  
  METHODS
  We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of treatments for acute paracetamol poisoning? We searched: Medline, Embase, The Cochrane Library, and other important databases up to October 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview).
  
  
  RESULTS
  At this update, searching of electronic databases retrieved 127 studies. After deduplication and removal of conference abstracts, 64 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 46 studies and the further review of 18 full publications. Of the 18 full articles evaluated, one systematic review was updated and one RCT was added at this update. In addition, two systematic reviews and three RCTs not meeting our inclusion criteria were added to the Comment sections. We performed a GRADE evaluation for three PICO combinations.
  
  
  CONCLUSIONS
  In this systematic overview we categorised the efficacy for six interventions, based on information about the effectiveness and safety of activated charcoal (single or multiple dose), gastric lavage, haemodialysis, liver transplant, methionine, and acetylcysteine.
authors.affiliation: MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK.
authors.forename: B Kevin
authors.initials: BK
authors.lastname: Park
authors.forename: James W
authors.initials: JW
authors.lastname: Dear
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Antoine
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D000111:Acetylcysteine / Q000627:therapeutic use; D002606:Charcoal / Q000627:therapeutic use; D005751:Gastric Lavage / Q000592:standards; D006801:Humans; D016031:Liver Transplantation / Q000592:standards; D008715:Methionine / Q000627:therapeutic use; D011041:Poisoning / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006435:Renal Dialysis / Q000592:standards; D016896:Treatment Outcome
chemical_list: D002606:Charcoal; D000082:Acetaminophen; D008715:Methionine; D000111:Acetylcysteine