title: [PROGRESS OF ALGINATE DERIVATIVES BASED ON BIOMEDICAL MATERIALS].
abstract: OBJECTIVE
  To summarize the current research status of alginate derivatives based on biomedical materials, and analyze several key points as novel clinical products.
  
  
  METHODS
  The general preparation and application methods of alginate derivatives based on biomedical materials at home and abroad were reviewed. The present status and problems were analyzed.
  
  
  RESULTS
  The derivation methods to prepare alginate derivatives include crosslink, sulfation, biological factors derivatization, hydrophobic modification, and graft copolymerization. With excellent bionic performance of structure and properties, many alginate derivatives are available for tissue engineering scaffolds, artificial organs, and drug delivery systems etc. However, more systematic applied basic research data should be collected and statistically analyzed for risk managements.
  
  
  CONCLUSIONS
  Alginate derivatives have good feasibility as novel medical products, meanwhile, systematic evaluation and verification should be executed for their safety, effectiveness, and suitability.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Wei
authors.forename: Qisheng
authors.initials: Q
authors.lastname: Gu
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Wang
authors.forename: Jimin
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000464:Alginates; D001672:Biocompatible Materials; D001861:Bone Regeneration; D001842:Bone and Bones / Q000378:metabolism / Q000503:physiopathology; D016503:Drug Delivery Systems; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D000464:Alginates; D001672:Biocompatible Materials