title: Evaluation of Oogenesis Aspects in Neonatal and Adult Mice after Toloaldoxime Treatment.
abstract: OBJECTIVE
  Oximes are important materials in organic chemistry. Synparamethyl benzal- dehyde oxime (toloaldoxime) is structurally similar to other oximes, hence we have studied its effects on the neonatal and adult female Balb/c mice reproductive systems in order to provide a platform for future studies on the production of female contraceptive drugs.
  
  
  METHODS
  In experimental study, we studied the effects of toloaldoxime on ovary growth and gonadal hormones of neonatal and adult Balb/c mice. A regression model for prediction was presented.
  
  
  RESULTS
  The effects of toloaldoxime on neonatal mice were more than adult mice. The greatest effect was on the number of Graafian follicles (59.6% in adult mice and 31.83% in neonatal mice). The least effect was on ovary weight, and blood serum lev- els of follicle stimulating hormone (FSH) and luteinizing hormone (LH).
  
  
  CONCLUSIONS
  According to the data obtained, toloaldoxime can be considered an anti- pregnancy substance.
authors.affiliation: Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fazeltabar Malekshah
authors.affiliation: Faculty of New Science and Technology, Tehran University, Tehran, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Sedighi
authors.affiliation: Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Kazem
authors.initials: K
authors.lastname: Parivar
authors.affiliation: Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Homa
authors.initials: H
authors.lastname: Mohseni Kouchesfahani
authors.affiliation: Faculty of Chemistry, Tarbiat Moalem University, Tehran, Iran.
authors.forename: Mohamadali
authors.initials: M
authors.lastname: Bigdeli
keywords: Balb/c Mouse; Fertility; Ovary; Toloaldoxime