title: The use of convalescent plasma to treat emerging infectious diseases: focus on Ebola virus disease.
abstract: OBJECTIVE
  The purpose of this review is to discuss the use of convalescent plasma for the treatment of emerging infectious diseases, focusing on the recent use for the treatment of Ebola virus disease (EVD).
  
  
  RESULTS
  Ebola convalescent plasma has been used as a therapy for treatment of EVD during the 2014 West Africa epidemic. Several cases from the United States and Europe have been recently published, in addition to multiple ongoing clinical trials in the United States and West Africa. Even more recently, convalescent plasma has been used for treatment of individuals with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.
  
  
  CONCLUSIONS
  Although the first reports of successful treatment with passive immune therapy date back to the early 1900s, convalescent plasma has materialized as a possible therapy for patients who develop infection from one of the emerging infectious diseases such as EVD or MERS-CoV, although the efficacy of such therapy has yet to be proven in clinical trials.
authors.affiliation: aDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia bDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Winkler
authors.forename: Scott A
authors.initials: SA
authors.lastname: Koepsell
mesh_terms: D016913:Blood Component Transfusion; D019142:Hemorrhagic Fever, Ebola / Q000097:blood / Q000276:immunology / Q000628:therapy*; D006801:Humans