title: [Significance of serum neuron-specific enolase before treatment in predicting brain metastases and prognosis of advanced non-small cell lung cancer].
abstract: OBJECTIVE
  To explore the value of serum neuron-specific enolase (NSE) before treatment in predicting brain metastases and prognosis of advanced non-small cell lung cancer (NSCLC).
  
  
  METHODS
  A total of 128 hospitalized patients with advanced NSCLC from Jan 2012 to Mar 2012 were followed up, and their clinicopathological data, serum NSE, carcinoembryonic antigen, cytokeratin 21-1 (cyfra21-1) levels, albumin (ALB), white blood cell (WBC) before treatment were analyzed retrospectively to determine the factors affecting brain metastasis and prognosis of advanced NSCLC.
  
  
  RESULTS
  Among the 128 NSCLC patients, 90 cases were of adenocarcinoma, 30 cases were of squamous cell carcinoma, and 8 cases were of large cell carcinoma. The median levels of pre-treatment NSE, CEA and cyfra21-1 were 13.6 ng/ml, 7.8 ng/ml and 6.1 ng/ml, respectively. The average levels of ALB and WBC were (35.41 ± 5.60) g/L and (8.16 ± 2.53) × 10⁹/ml, respectively. Multi-variate logistic regression analysis showed that serum NSE before treatment was associated with brain metastasis of advanced NSCLC (P = 0.030). Pre-treatment NSE levels were (34.18 ± 28.48) ng/ml in 28 patients with brain metastasis and (13.87 ± 4.49) ng/ml in 98 patients without brain metastasis (P < 0.05). The median survival time were 3.5 months in patients with normal levels of NSE, and 10.7 months in patients with elevated levels of NSE pre-treatment (P < 0.05).
  
  
  CONCLUSIONS
  A higher pre-treatment level of NSE is closely correlated with brain metastasis of advanced NSCLC, and can be used as a predictor of brain metastases in advanced NSCLC. High pre-treatment levels of NSE indicate a poor prognosis in advanced NSCLC patients.
authors.affiliation: Clinical Laboratory Department of Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China; Email: yanc99@sina.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Clinical Laboratory Department of Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.affiliation: Clinical Laboratory Department of Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Clinical Laboratory Department of Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Clinical Laboratory Department of Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China.
authors.forename: Guangjian
authors.initials: G
authors.lastname: Su
authors.affiliation: Clinical Laboratory Department of Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China.
authors.forename: Chuanhui
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Clinical Laboratory Department of Fujian Tumor Hospital, Fujian Medical University, Fuzhou 350014, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000201:enzymology / Q000556:secondary; D000951:Antigens, Neoplasm / Q000097:blood; D001932:Brain Neoplasms / Q000556:secondary*; D002272:Carcinoembryonic Antigen / Q000097:blood; D018287:Carcinoma, Large Cell / Q000097:blood / Q000201:enzymology / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000201:enzymology* / Q000556:secondary*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000201:enzymology / Q000556:secondary; D006801:Humans; D053539:Keratin-19 / Q000097:blood; D007958:Leukocyte Count; D008175:Lung Neoplasms / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011379:Prognosis; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis
chemical_list: D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; D012709:Serum Albumin; C102012:antigen CYFRA21.1; D010751:Phosphopyruvate Hydratase