title: Food Protein-Induced Enterocolitis Syndrome.
abstract: Food protein-induced enterocolitis syndrome (FPIES) is a rare, non-immunoglobulin E-mediated gastrointestinal food allergy primarily diagnosed in infancy, but has also been reported in older children and adults. Acute FPIES reactions typically present with delayed, repetitive vomiting, lethargy, and pallor within 1 to 4 hours of food ingestion. Chronic FPIES typically presents with protracted vomiting and/or diarrhea, and weight loss or poor growth. Common foods triggering FPIES include cow's milk, soy, rice, oats, fish, and egg. More detailed diagnostic criteria may help in increasing awareness of FPIES and reducing delayed diagnoses or misdiagnoses.
authors.affiliation: Division of Pediatric Allergy & Immunology, Rady Children's Hospital San Diego, University of California, San Diego, 3020 Children's Way, MC 5114, San Diego, CA 92123, USA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Leonard
authors.affiliation: Division of Pediatric Allergy, Department of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, Box 1198, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: anna.nowak-wegrzyn@mssm.edu.
authors.forename: Anna
authors.initials: A
authors.lastname: Nowak-Węgrzyn
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D003967:Diarrhea; D004044:Dietary Proteins / Q000009:adverse effects* / Q000276:immunology*; D004760:Enterocolitis / Q000175:diagnosis* / Q000209:etiology* / Q000276:immunology; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000209:etiology* / Q000276:immunology; D006801:Humans; D053609:Lethargy; D010167:Pallor; D013577:Syndrome; D014839:Vomiting; D015431:Weight Loss
chemical_list: D004044:Dietary Proteins
keywords: FPIES; Food protein–induced enterocolitis syndrome; Gastrointestinal food allergy; Non–IgE-mediated food allergy