title: Psoriasis and Cardiovascular Disease.
abstract: Psoriasis is a systemic inflammatory disease that confers significant risk of metabolic derangements and adverse cardiovascular outcomes. Early detection and treatment of modifiable risk factors and modulation of the systemic inflammatory response are important treatment goals. Studies have shown that there is a significant lack of awareness of the relationship between psoriasis and cardiovascular disease, so future considerations should focus on education of and collaboration with health care providers, especially those in primary care, and development of updated, rigorous screening guidelines. In addition, targeted biologic therapies such as TNF-a inhibitors have shown immense promise in targeting the systemic inflammation associated with psoriatic disease, but whether they will impact long-term cardiovascular outcomes remains to be seen.
authors.affiliation: Clinical Unit for Research Trials and Outcomes in Skin (CURTIS), Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, Suite 240, Boston, MA 02114, USA.
authors.forename: Kathryn T
authors.initials: KT
authors.lastname: Shahwan
authors.affiliation: Clinical Unit for Research Trials and Outcomes in Skin (CURTIS), Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, Suite 240, Boston, MA 02114, USA. Electronic address: harvardskinstudies@partners.org.
authors.forename: Alexa B
authors.initials: AB
authors.lastname: Kimball
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control*; D003879:Dermatologic Agents / Q000627:therapeutic use; D048909:Diabetes Complications; D015870:Gene Expression; D006801:Humans; D008403:Mass Screening; D011565:Psoriasis / Q000150:complications* / Q000628:therapy; D012307:Risk Factors; D057185:Sedentary Behavior; D012907:Smoking / Q000009:adverse effects
chemical_list: D015415:Biomarkers; D003879:Dermatologic Agents
keywords: Cardiovascular disease; Cerebrovascular disease; Metabolic syndrome; Psoriasis; Psoriatic arthritis