title: Consumption of systemic antifungal agents among acute care hospitals in Catalonia (Spain), 2008-2013.
abstract: Objective To know the patterns and consumption trends (2008-2013) of antifungal agents for systemic use in 52 acute care hospitals affiliated to VINCat Program in Catalonia (Spain). Methods Consumption was calculated in defined daily doses (DDD)/100 patient-days and analyzed according to hospital size and complexity and clinical departments. Results Antifungal consumption was higher in intensive care units (ICU) (14.79) than in medical (3.08) and surgical departments (1.19). Fluconazole was the most consumed agent in all type of hospitals and departments. Overall antifungal consumption increased by 20.5%during the study period (p = 0.066); a significant upward trend was observed in the consumption of both azoles and echinocandins. In ICUs, antifungal consumption increased by 12.4% (p = 0.019). Conclusions The study showed a sustained increase in the overall consumption of systemic antifungals in a large number of acute care hospitals of different characteristics in Catalonia. In ICUs there was a trend towards the substitution of older agents by the new ones.
authors.affiliation: a VINCat Coordinating Centre , Department of Health , Catalonia, Barcelona , Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Fondevilla
authors.affiliation: b Department of Pharmacy , Hospital del Mar, Universitat Autònoma de Barcelona , Barcelona , Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Grau
authors.affiliation: c Consulting Service on Methodology for Biomedical Research , IMIM , Barcelona , Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Mojal
authors.affiliation: d Department of Intensive Medicine , Hospital Arnau de Vilanova , Lleida , Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Palomar
authors.affiliation: e Department of Microbiology , Hospital Universitari Germans Trias i Pujol , Badalona , Spain.
authors.forename: Lurdes
authors.initials: L
authors.lastname: Matas
authors.affiliation: Director of VINCat Program, VINCat Coordinating Centre, Department of Health, Catalonia, Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Gudiol
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001393:Azoles / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D004363:Drug Utilization / Q000706:statistics & numerical data*; D054714:Echinocandins / Q000627:therapeutic use*; D005658:Fungi / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D009181:Mycoses / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D016377:Organ Transplantation / Q000009:adverse effects; D012189:Retrospective Studies; D013030:Spain; D013503:Surgery Department, Hospital / Q000706:statistics & numerical data
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D054714:Echinocandins; D000666:Amphotericin B
keywords: Antimycotic use; antifungal consumption; azoles; echinocandins; fluconazole