title: No Association Between Transient Hypothyroxinemia of Prematurity and Neurodevelopmental Outcome in Young Adulthood.
abstract: BACKGROUND
  Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood.
  
  
  OBJECTIVE
  The objective was to examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at a young adult age.
  
  
  METHODS
  This study was part of the 19-year follow-up of the Project On Preterm and Small-for-gestational-age birth (POPS) cohort, which included infants born very preterm (ie, <32 wk) and/or with a very low birth weight (ie, <1500 g).
  
  
  METHODS
  This was a multicenter study.
  
  
  METHODS
  There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP.
  
  
  METHODS
  T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism. THoP was defined as a total T4 concentration < -3 SD of the daily mean (approximately 60 nmol/L).
  
  
  METHODS
  Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen's examination of minor neurological dysfunction, respectively.
  
  
  RESULTS
  THoP was not associated with IQ score (mean difference, 0 [95% confidence interval, -3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, -1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics.
  
  
  CONCLUSIONS
  No associations between THoP and neurodevelopmental outcome at age 19 years were found.
authors.affiliation: Department of Pediatrics (J.J.H., J.I., J.R., M.J.J.F.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands; and Netherlands Organization for Applied Scientific Research (S.M.v.d.P., P.H.V.), Child Health, 2316 ZL Leiden, The Netherlands.
authors.forename: Jonneke J
authors.initials: JJ
authors.lastname: Hollanders
authors.affiliation: Department of Pediatrics (J.J.H., J.I., J.R., M.J.J.F.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands; and Netherlands Organization for Applied Scientific Research (S.M.v.d.P., P.H.V.), Child Health, 2316 ZL Leiden, The Netherlands.
authors.forename: Joël
authors.initials: J
authors.lastname: Israëls
authors.affiliation: Department of Pediatrics (J.J.H., J.I., J.R., M.J.J.F.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands; and Netherlands Organization for Applied Scientific Research (S.M.v.d.P., P.H.V.), Child Health, 2316 ZL Leiden, The Netherlands.
authors.forename: Sylvia M
authors.initials: SM
authors.lastname: van der Pal
authors.affiliation: Department of Pediatrics (J.J.H., J.I., J.R., M.J.J.F.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands; and Netherlands Organization for Applied Scientific Research (S.M.v.d.P., P.H.V.), Child Health, 2316 ZL Leiden, The Netherlands.
authors.forename: Paul H
authors.initials: PH
authors.lastname: Verkerk
authors.affiliation: Department of Pediatrics (J.J.H., J.I., J.R., M.J.J.F.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands; and Netherlands Organization for Applied Scientific Research (S.M.v.d.P., P.H.V.), Child Health, 2316 ZL Leiden, The Netherlands.
authors.forename: Joost
authors.initials: J
authors.lastname: Rotteveel
authors.affiliation: Department of Pediatrics (J.J.H., J.I., J.R., M.J.J.F.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands; and Netherlands Organization for Applied Scientific Research (S.M.v.d.P., P.H.V.), Child Health, 2316 ZL Leiden, The Netherlands.
authors.forename: Martijn J J
authors.initials: MJ
authors.lastname: Finken
mesh_terms: D015331:Cohort Studies; D003409:Congenital Hypothyroidism / Q000150:complications* / Q000453:epidemiology*; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D062071:Infant, Extremely Premature; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D007361:Intelligence Tests; D008297:Male; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology*; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D013974:Thyroxine / Q000097:blood / Q000172:deficiency*; D055815:Young Adult
chemical_list: D013974:Thyroxine