title: Building the foundation for genomics in precision medicine.
abstract: Precision medicine has the potential to profoundly improve the practice of medicine. However, the advances required will take time to implement. Genetics is already being used to direct clinical decision-making and its contribution is likely to increase. To accelerate these advances, fundamental changes are needed in the infrastructure and mechanisms for data collection, storage and sharing. This will create a continuously learning health-care system with seamless cycling between clinical care and research. Patients must be educated about the benefits of sharing data. The building blocks for such a system are already forming and they will accelerate the adoption of precision medicine.
authors.affiliation: Partners HealthCare Personalized Medicine, Boston, Massachusetts 02115, USA.|Partners HealthCare Research Information Services and Computing, Charlestown, Massachusetts 02129, USA.
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Aronson
authors.affiliation: Partners HealthCare Personalized Medicine, Boston, Massachusetts 02115, USA.|Department of Pathology, Brigham &Women's Hospital, Boston, Massachusetts 02115, USA.|Harvard Medical School, Boston, Massachusetts 02115, USA.|The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
authors.forename: Heidi L
authors.initials: HL
authors.lastname: Rehm
mesh_terms: D001291:Attitude of Health Personnel; D064790:Clinical Laboratory Services; D057286:Electronic Health Records; D005826:Genetics, Medical / Q000458:organization & administration / Q000639:trends; D023281:Genomics / Q000458:organization & administration* / Q000639:trends*; D006801:Humans; D010361:Patients; D010820:Physicians; D057285:Precision Medicine / Q000379:methods* / Q000639:trends*; D012108:Research Personnel