title: Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype.
abstract: BACKGROUND
  The CpG island methylator phenotype (CIMP) was first characterized in colorectal cancer but since has been extensively studied in several other tumor types such as breast, bladder, lung, and gastric. CIMP is of clinical importance as it has been reported to be associated with prognosis or response to treatment. However, the identification of a universal molecular basis to define CIMP across tumors has remained elusive.
  
  
  RESULTS
  We perform a genome-wide methylation analysis of over 2000 tumor samples from 5 cancer sites to assess the existence of a CIMP with common molecular basis across cancers. We then show that the CIMP phenotype is associated with specific gene expression variations. However, we do not find a common genetic signature in all tissues associated with CIMP.
  
  
  CONCLUSIONS
  Our results suggest the existence of a universal epigenetic and transcriptomic signature that defines the CIMP across several tumor types but does not indicate the existence of a common genetic signature of CIMP.
authors.affiliation: CBIO-Centre for Computational Biology, Mines Paristech, PSL-Research University, 35 Rue Saint-Honore, Fontainebleau, F-77300, France. matahi.moarii@mines-paristech.fr.|Department of Bioinformatics, Biostatistics and System Biology, Institut Curie, 11-13 Rue Pierre et Marie Curie, Paris, F-75248, France. matahi.moarii@mines-paristech.fr.|U900, INSERM, 11-13 Rue Pierre et Marie Curie, Paris, F-75248, France. matahi.moarii@mines-paristech.fr.
authors.forename: Matahi
authors.initials: M
authors.lastname: Moarii
authors.affiliation: UMR932, Immunity and Cancer Team, Institut Curie, 26 Rue d'Ulm, Paris, 75006, France. fabien.reyal@curie.fr.|Department of Translational Research, Residual Tumor and Response to Treatment Team, Institut Curie, 26 Rue d'Ulm, Paris, 75006, France. fabien.reyal@curie.fr.|Department of Surgery, Institut Curie, 26 Rue d'Ulm, Paris, 75006, France. fabien.reyal@curie.fr.
authors.forename: Fabien
authors.initials: F
authors.lastname: Reyal
authors.affiliation: CBIO-Centre for Computational Biology, Mines Paristech, PSL-Research University, 35 Rue Saint-Honore, Fontainebleau, F-77300, France. jean-philippe.vert@mines-paristech.fr.|Department of Bioinformatics, Biostatistics and System Biology, Institut Curie, 11-13 Rue Pierre et Marie Curie, Paris, F-75248, France. jean-philippe.vert@mines-paristech.fr.|U900, INSERM, 11-13 Rue Pierre et Marie Curie, Paris, F-75248, France. jean-philippe.vert@mines-paristech.fr.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Vert
mesh_terms: D014408:Biomarkers, Tumor; D018899:CpG Islands / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics*; D030541:Databases, Genetic; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D009154:Mutation; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins