title: Analysis of peripapillary choroidal thickness in non-arteritic anterior ischaemic optic neuropathy.
abstract: OBJECTIVE
  To analyse peripapillary choroidal thickness (PCT) in non-arteritic ischaemic optic neuropathy (NAION).
  
  
  METHODS
  28 patients diagnosed with NAION (37 affected and 19 unaffected eyes) and 38 disease-free control individuals (38 eyes) were analysed using enhanced-depth imaging of spectral-domain optical coherence tomography. A vertical and a horizontal raster scan centred on the optic nerve were obtained per eye. PCT was measured at the superior, inferior, nasal and temporal quadrants from the posterior edge of the retinal pigment epithelium to the choroid-sclera junction at 500 μm intervals up to 2000 μm away from the optic nerve. Statistical analysis was used to compare average PCT and to correlate PCT with other ocular and systemic parameters.
  
  
  RESULTS
  Mean PCT in NAION eyes and control group was 148.18±42.68 μm and 182.90±59.81 μm, respectively (p=0.005). Except for inferior PCT (p=0.158), superior, nasal and temporal PCT were significantly thinner in the NAION eyes than in the control group (p=0.006, 0.002 and 0.046). Thinner PCT, adjusted for refractive error, was associated with the diagnosis of NAION (p=0.048). Similarly, unaffected contralateral eyes showed a significant thinner PCT compared with the control group (p=0.024). Diagnosis of NAION was negatively associated with PCT in NAION eyes (p=0.008; OR 0.98; 95% CI 0.97 to 0.99) and in their contralateral unaffected eyes (p=0.043; OR 0.98; 95% CI 0.97 to 0.99).
  
  
  CONCLUSIONS
  Eyes affected by NAION and contralateral unaffected eyes showed significantly thinner PCT compared with disease-free control eyes after adjusting for refractive error.
authors.affiliation: Department of Ophthalmology, University Hospital Virgen de la Victoria, Málaga, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: García-Basterra
authors.affiliation: Department of Ophthalmology, University Hospital Virgen de la Victoria, Málaga, Spain.
authors.forename: Iliass
authors.initials: I
authors.lastname: Lahrach
authors.affiliation: Department of Ophthalmology, University Hospital Virgen de la Victoria, Málaga, Spain.
authors.forename: María Josefa
authors.initials: MJ
authors.lastname: Morillo Sánchez
authors.affiliation: Department of Ophthalmology, Eye Clinic, Torbay Hospital, South Devon Healthcare NHS Foundation Trust, Torquay, UK.
authors.forename: Radua
authors.initials: R
authors.lastname: Kamal-Salah
authors.affiliation: Department of Preventive Medicine and Public Health, University of Málaga, Málaga, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Ríus-Díaz
authors.affiliation: Department of Human Physiology and Physical Sports Education, Centro de Investigaciones Médico-Sanitarias, University of Málaga, Málaga, Spain.
authors.forename: Marc Stefan
authors.initials: MS
authors.lastname: Dawid Milner
authors.affiliation: Department of Ophthalmology, University Hospital Virgen de la Victoria, Málaga, Spain.|Department of Ophthalmology, Centro de Investigaciones Médico-Sanitarias, University of Málaga, Málaga, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: García-Campos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000000981:diagnostic imaging*; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D014794:Visual Fields
keywords: Choroid; Imaging; Optic Nerve