title: Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.
abstract: Breast cancer, an emerging disease among the women population, occurs due to overexpression of estrogens. The enzyme aromatase plays a key rate limiting role in the biosynthesis of estrogens. Certain clinical advantages of the use of exemestane, a steroidal aromatase inhibitor over non-steroidal aromatase inhibitors have drawn the attention of researchers for the development of novel steroidal aromatase inhibitors.The current review is a humble attempt to compile the reports by various researchers till date on the synthesis of steroidal aromatase inhibitors. It has been tried to encompass the structural modifications carried out by various researchers in the steroid ring system by taking up the functional group modifications on rings A, B, ring A/B junction, ring-D, ring modifications, bridged derivatives and heterocyclic ring-fused derivatives in a systematic way.
authors.affiliation: Pharmacy Department, Faculty of Tech. and Engg., The M. S. University of Baroda, Vadodara 390 001, Gujarat, India. Electronic address: mryadav11@yahoo.co.in.
authors.forename: Mange Ram
authors.initials: MR
authors.lastname: Yadav
authors.affiliation: Pharmacy Department, Faculty of Tech. and Engg., The M. S. University of Baroda, Vadodara 390 001, Gujarat, India.
authors.forename: Mahesh A
authors.initials: MA
authors.lastname: Barmade
authors.affiliation: Pharmacy Department, Faculty of Tech. and Engg., The M. S. University of Baroda, Vadodara 390 001, Gujarat, India.
authors.forename: Riyaj S
authors.initials: RS
authors.lastname: Tamboli
authors.affiliation: Pharmacy Department, Faculty of Tech. and Engg., The M. S. University of Baroda, Vadodara 390 001, Gujarat, India.
authors.forename: Prashant R
authors.initials: PR
authors.lastname: Murumkar
mesh_terms: D001141:Aromatase / Q000378:metabolism*; D047072:Aromatase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D015195:Drug Design; D005260:Female; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D047072:Aromatase Inhibitors; D001141:Aromatase
keywords: Aromatase inhibitors; Breast cancer; Medicinal chemistry; Molecular modeling; Ring substituted androstanes; Steroids