title: A comparative study of bone mineral density among patients with obstructive lung diseases in Korea.
abstract: BACKGROUND
  Decreased bone mineral density (BMD) in patients with obstructive lung disease (OLD) is well known. However, the relationship between BMD and asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is not yet known.
  
  
  OBJECTIVE
  To determine the relationship between ACOS and decreased BMD.
  
  
  METHODS
  We evaluated the relationship between OLD phenotypes and decreased BMD in subjects from the Korean National Health and Nutrition Survey IV and V (2008-2011). Data on 979 subjects who underwent spirometry and dual-energy X-ray absorptiometry were included in the study.
  
  
  RESULTS
  Patients with ACOS had lower femur, femur neck and lumbar T-scores than those with COPD (P = 0.048, P = 0.001 and P = 0.002, respectively). On multivariate logistic regression analysis, the ACOS group had a two-fold higher risk of developing osteopenia and low BMD compared to the COPD group (OR 1.960, 95%CI 1.011-3.800, P = 0.046; OR 1.974, 95%CI 1.019-3.824, P = 0.044).
  
  
  CONCLUSIONS
  The rate of bone loss differed among subjects with the asthma, COPD and ACOS OLD phenotypes. In particular, patients with ACOS had a higher risk of developing osteopenia and low BMD than those with COPD.
authors.affiliation: Department of Pulmonary and Allergy, Department of Internal Medicine, Regional Respiratory Center, Yeungnam University Hospital, Daegu, Republic of Korea.
authors.forename: D W
authors.initials: DW
authors.lastname: Lee
authors.affiliation: Department of Pulmonary and Allergy, Department of Internal Medicine, Regional Respiratory Center, Yeungnam University Hospital, Daegu, Republic of Korea.
authors.forename: E Y
authors.initials: EY
authors.lastname: Choi
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D001249:Asthma / Q000150:complications / Q000503:physiopathology*; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009749:Nutrition Surveys; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D013147:Spirometry; D013577:Syndrome