title: Migraine and possible etiologic heterogeneity for hormone-receptor-negative breast cancer.
abstract: Migraine headache is often timed with the menstrual cycle. Some studies have reported reduced risk of breast cancer in migraineurs but most of those did not distinguish menstrually-related from non-menstrually-related migraine. To examine the possible associations between breast cancer and migraine overall and between cancer subcategories and the two migraine subtypes, we used a cohort study of 50,884 women whose sister had breast cancer and a sister-matched case-control study including 1,418 young-onset (<50 years) breast cancer cases. We analyzed the two studies individually and also in tandem via a hybrid Cox model, examining subcategories of breast cancer in relation to menstrually-related and non-menstrually-related migraine. History of migraine was not associated with breast cancer overall. Migraine showed an inverse association with ductal carcinoma in situ (HR = 0.77; 95% CI (0.62,0.96)). Also, women with non-menstrually-related migraine had increased risk (HR = 1.30, 95% CI (0.93,1.81)) while women with menstrually-related migraine had decreased risk (HR = 0.63, 95% CI (0.42,0.96)) of hormone-receptor-negative (ER-/PR-) cancer, with a significant contrast in estimated effects (P = 0.005). While replication of these subset-based findings will be needed, effect specificity could suggest that while migraine has little overall association with breast cancer, menstrual migraine may be associated with reduced risk of ER-/PR- breast cancer.
authors.affiliation: Biostatistics &Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park NC.
authors.forename: Min
authors.initials: M
authors.lastname: Shi
authors.affiliation: Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park.|Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: DeRoo
authors.affiliation: Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park.
authors.forename: Dale P
authors.initials: DP
authors.lastname: Sandler
authors.affiliation: Biostatistics &Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park NC.
authors.forename: Clarice R
authors.initials: CR
authors.lastname: Weinberg
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000150:complications / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D006801:Humans; D008598:Menstruation; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000235:genetics* / Q000473:pathology; D016016:Proportional Hazards Models; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000172:deficiency / Q000235:genetics; D011960:Receptors, Estrogen / Q000172:deficiency / Q000235:genetics; D011980:Receptors, Progesterone / Q000172:deficiency / Q000235:genetics; D012189:Retrospective Studies; D035781:Siblings; D064726:Triple Negative Breast Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human