title: [Hyperuricaemia and metabolic syndrome in obese children and adolescents].
abstract: BACKGROUND
  Hyperuricaemia has been suggested as an additional metabolic factor in adult obese patients, but it has not been sufficiently studied in paediatric.
  
  
  OBJECTIVE
  To assess the relationship between serum uric acid levels (SUAL) with the level of general and visceral obesity, and other biochemical parameters in children and adolescents of Santiago, Chile.
  
  
  METHODS
  A cross sectional study was conducted on 770 children and adolescents (ages: 6-15 y.) from a public school in Santiago, Chile, of whom 227 (29%) were obese (BMI>2 SD, WHO growth standards). Ninety subjects were randomly selected and 77 with no other chronic disease (41 males) accepted to participate. Data was collected on weight, stature, abdominal circumference (AC), visceral adiposity using ultrasound, and other biochemical measurements including fasting glucose, insulin, serum lipids, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and SUAL.
  
  
  RESULTS
  The mean SUAL was 0.200±0.065 mmol/L, and was increased in children with hyperinsulinism (adjusted by age: 0.221±0.075 vs. 0.183±0.054 mmol/L; P<.01), with no significant differences according to HOMA. Differences were also found between children with ALT>or<26 U/mL: 0.238±0.070 vs. 0.178±0.054 mmol/L, P<.001. The logistic regression showed the increased SUAL was only associated with increased ALT. No significant differences were found in general or visceral adiposity measurements or fatty liver.
  
  
  CONCLUSIONS
  Children and adolescents from Santiago, Chile have higher uric acid serum uric acid levels as well as an association with increased ALT and insulin. It is demonstrated in this study that uric acid should be measured in obese children and adolescents, and in their follow up.
authors.affiliation: Departamento de Pediatría, Facultad de Medicina Campus Centro, Universidad de Chile, Santiago, Chile. Electronic address: ccastd@med.uchile.cl.
authors.forename: Carlos
authors.initials: C
authors.lastname: Castillo-Durán
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, Chile.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Sepúlveda A
authors.affiliation: Departamento de Pediatría, Facultad de Medicina Campus Centro, Universidad de Chile, Santiago, Chile.
authors.forename: Aníbal
authors.initials: A
authors.lastname: Espinoza G
authors.affiliation: Servicio de Pediatría, Hospital San Borja Arriarán, Santiago, Chile.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Rebollo G
authors.affiliation: Departamento de Pediatría, Facultad de Medicina Campus Centro, Universidad de Chile, Santiago, Chile; Departamento de Gastroenterología y Nutrición Pediátrica, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Catalina
authors.initials: C
authors.lastname: Le Roy O
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000378:metabolism; D002648:Child; D002677:Chile / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000453:epidemiology; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology*; D007328:Insulin / Q000378:metabolism; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D009765:Obesity / Q000453:epidemiology*; D011446:Prospective Studies; D014527:Uric Acid / Q000097:blood*
chemical_list: D007328:Insulin; D014527:Uric Acid; D000410:Alanine Transaminase
keywords: Adolescentes; Adolescents; Children; Hiperuricemia; Hyperuricaemia; Metabolic syndrome; Niños; Obesidad; Obesity; Serum uric acid; Síndrome metabólico; Ácido úrico sérico