title: Intravitreal Dexamethasone Implant for Treatment of Refractory Behçet Posterior Uveitis: One-year Follow-up Results.
abstract: OBJECTIVE
  To investigate the results of dexamethasone (DEX) implant in the treatment of eyes with refractory Behçet posterior uveitis.
  
  
  METHODS
  A total of 17 eyes of 12 patients with active Behçet posterior uveitis were enrolled in the study. A single intravitreal injection of DEX implant was applied to each eye. Best corrected visual acuity (BCVA), central macular thickness (CMT), vitreous haze score, and intraocular pressure (IOP) were determined, at baseline and control visits of months 1, 3, 6, and 12.
  
  
  RESULTS
  The mean BCVA was significantly increased from baseline at each control visit (all p < 0.05). The mean CMT and vitreous haze score were significantly decreased from baseline at each control visit (all p < 0.05). Three eyes showed IOP spikes requiring topical anti-glaucomatous treatment.
  
  
  CONCLUSIONS
  A single injection of DEX implant was safe and effective, as an additional treatment to systemic immunomodulatory drugs, in the treatment of refractory Behçet posterior uveitis, for a 6-month period.
authors.affiliation: a Department of Ophthalmology , Gaziantep University Medicine School , Gaziantep , Turkey .
authors.forename: Erol
authors.initials: E
authors.lastname: Coşkun
authors.affiliation: a Department of Ophthalmology , Gaziantep University Medicine School , Gaziantep , Turkey .
authors.forename: Pelin
authors.initials: P
authors.lastname: Celemler
authors.affiliation: c Gaziantep University Medicine School, Department of Rheumatology , Gaziantep , Turkey.
authors.forename: Gezmis
authors.initials: G
authors.lastname: Kimyon
authors.affiliation: b Recep Tayyip Erdoğan University Medicine School, Department of Ophthalmology , Rize , Turkey , and.
authors.forename: Veysi
authors.initials: V
authors.lastname: Öner
authors.affiliation: c Gaziantep University Medicine School, Department of Rheumatology , Gaziantep , Turkey.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Kisacik
authors.affiliation: a Department of Ophthalmology , Gaziantep University Medicine School , Gaziantep , Turkey .
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Erbagci
authors.affiliation: c Gaziantep University Medicine School, Department of Rheumatology , Gaziantep , Turkey.
authors.forename: Ahmet Mesut
authors.initials: AM
authors.lastname: Onat
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D015866:Uveitis, Posterior / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014792:Visual Acuity; D014822:Vitreous Body; D055815:Young Adult
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone
keywords: Behçet disease; dexamethasone; posterior uveitis; treatment; uveitis