title: The relationship of the apolipoprotein E gene polymorphism in Turkish Type 2 Diabetic Patients with and without diabetic foot ulcers.
abstract: OBJECTIVE
  The aim of this study was to investigate the association between Apolipoprotein E (ApoE) gene polymorphism in the development of diabetic foot ulcers in Type 2 diabetes Turkish patients.
  
  
  METHODS
  The ApoE genotypes were determined retrospectively in 50 patients with diabetic foot and 50 without diabetic foot and a control group of 50 healthy individuals.
  
  
  RESULTS
  The genotype ApoE distribution did differ between the control group (E2E3 44%, E3E3 38%, E3E4 18%) and Type 2 Diabetic Patients (E2E3 6%, E3E3 81%, E3E4 16%) (p<0.001). The genotype ApoE distribution did not differ between Type 2 Diabetic Patients group (E2E3 4%, E3E3 86%, E3E4 4%) and diabetic foot ulcers (E2E3 8%, E3E3 76%, E3E4 16%) (p>0.05). The frequency of the E2,E3,E4 allele in between the control group and Type 2 Diabetic Patients were no similar for the groups (E2 22%, E3 69%, E4 9% and E2 3%, E3 90.5%, E4 6.5%, respectively) (p<0.001). The frequency of the E2-E4 allele in between the Type 2 Diabetic Patients and diabetic foot ulcers were similar for the groups (E2 2%, E3 93%, E4 5% and E2 4%, E3 88%, E4 8%, respectively) (p>0.05).
  
  
  CONCLUSIONS
  The gene polymorphism of ApoE and E3 allele are a risk factor for diabetes, but gene polymorphism of ApoE is not an independent risk factor for diabetic foot. Lack of association between ApoE gene polymorphism and Type 2 diabetic foot ulcers might be due to ethnic differences.
authors.affiliation: Ege University Medical School, Department of Endocrinology and Metabolic Diseases, Bornova, Izmir, Turkey. Electronic address: drmerdogan61@hotmail.com.
authors.forename: Erdogan
authors.initials: E
authors.lastname: Mehmet
authors.affiliation: Ege University Medical School, Department of Medical Biology, Bornova, Izmir, Turkey.
authors.forename: Eroglu
authors.initials: E
authors.lastname: Zuhal
authors.affiliation: Necmettin Erbakan University Medical School, Department of Endocrinology and Metabolic Diseases, Konya, Turkey.
authors.forename: Kulaksizoglu
authors.initials: K
authors.lastname: Mustafa
authors.affiliation: Ministry of Health, Numune Education and Research Hospital, Internal Medicine, Adana, Turkey.
authors.forename: Solmaz
authors.initials: S
authors.lastname: Soner
authors.affiliation: Ege University Medical School, Department of Medical Biology, Bornova, Izmir, Turkey.
authors.forename: Tetik
authors.initials: T
authors.lastname: Aslı
authors.affiliation: Ege University Medical School, Department of Endocrinology and Metabolic Diseases, Bornova, Izmir, Turkey.
authors.forename: Cetinkalp
authors.initials: C
authors.lastname: Sevki
mesh_terms: D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D017719:Diabetic Foot / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D014421:Turkey
chemical_list: C000612345:ApoE protein, human; D001057:Apolipoproteins E
keywords: ApoE gene polymorphism; Diabetic foot ulcers; Turkish population