title: The Role of Matricellular Proteins in Brain Edema after Subarachnoid Hemorrhage.
abstract: Accumulated evidence suggests that blood-brain barrier disruption or brain edema is an important pathologic manifestation for poor outcome after aneurysmal subarachnoid hemorrhage. Many molecules may be involved, acting simultaneously or at different stages during blood-brain barrier disruption via multiple independent or interconnected signaling pathways. Matricellular protein is a class of nonstructural, secreted, and multifunctional extracellular matrix proteins, which potentially mediates brain edema formation. This study reviews the role of osteopontin and tenascin-C, representatives of matricellular proteins, in the context of brain edema formation after subarachnoid hemorrhage in both clinical and experimental settings.
authors.affiliation: Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. suzuki02@clin.medic.mie-u.ac.jp.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Fujimoto
authors.affiliation: Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Shiba
authors.affiliation: Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Kawakita
authors.affiliation: Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ichikawa
authors.affiliation: Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka, Mie, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kanamaru
authors.affiliation: Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Imanaka-Yoshida
authors.affiliation: Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D037161:Galectins / Q000378:metabolism; D006801:Humans; D015676:Osteonectin / Q000378:metabolism; D053495:Osteopontin / Q000378:metabolism; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000378:metabolism*; D019063:Tenascin / Q000378:metabolism; D019700:Thrombospondin 1 / Q000378:metabolism; D019699:Thrombospondins / Q000378:metabolism; D000099262:Thrombospondin 2
chemical_list: D015815:Cell Adhesion Molecules; D037161:Galectins; D015676:Osteonectin; D053495:Osteopontin; D019063:Tenascin; D019700:Thrombospondin 1; D019699:Thrombospondins; D000099262:Thrombospondin 2; C512835:POSTN protein, human
keywords: Blood-brain barrier; Cerebral edema; Early brain injury; Matricellular protein; Subarachnoid hemorrhage