title: Sirtuins: Possible Clinical Implications in Cardio and Cerebrovascular Diseases.
abstract: Mammalian sirtuins (SIRT1-7) are NAD+-dependent deacetylases, which play an important role in aging and in a wide range of cellular functions. SIRT1, the best-characterized member of the family, acts as a sensor of the redox state and triggers in the cell the appropriate defense response. A large body of evidence has showed that SIRT1 induces both cellular and systemic protective effects in the cardiovascular system by preventing stress-induced apoptosis and senescence, and mitigating endothelial dysfunction. Hence, SIRT1 is now foreseen as a potential therapeutic target for a growing number of cardiovascular diseases. Recently, it has been suggested that SIRT1 activation could also be considered as a neuroprotective strategy. Indeed, SIRT1 protects against ischemia/reperfusion injury both in vitro and in vivo and avoids severe ischemic damage by preserving cerebral blood flow. In the last years it was suggested that others sirtuins, in particular SIRT3 and SIRT6, could exert beneficial effects in vascular syndromes. The aim of this review was to describe and discuss recent experimental evidence on the effects of SIRT1 and other sirtuins on the pathophysiology of cardio- and cerebrovascular diseases, underlying a potential therapeutic effect of these enzymes in the treatment and/or prevention of such conditions.
authors.forename: Valeria
authors.initials: V
authors.lastname: Conti
authors.forename: Maurizio
authors.initials: M
authors.lastname: Forte
authors.forename: Graziamaria
authors.initials: G
authors.lastname: Corbi
authors.forename: Giusy
authors.initials: G
authors.lastname: Russomanno
authors.forename: Luigi
authors.initials: L
authors.lastname: Formisano
authors.forename: Alessandro
authors.initials: A
authors.lastname: Landolfi
authors.forename: Viviana
authors.initials: V
authors.lastname: Izzo
authors.forename: Amelia
authors.initials: A
authors.lastname: Filippelli
authors.affiliation: Vascular Pathophysiology Unit, IRCCS Neuromed, Pozzilli (IS), Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Vecchione
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
authors.forename: Albino
authors.initials: A
authors.lastname: Carrizzo
mesh_terms: D017209:Apoptosis; D002318:Cardiovascular Diseases / Q000378:metabolism*; D016922:Cellular Senescence; D002561:Cerebrovascular Disorders / Q000378:metabolism*; D006801:Humans; D037761:Sirtuins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D037761:Sirtuins
keywords: SIRT1; SIRT3; SIRT6; drugs; vascular function.