title: Relationship Between Vertical and Horizontal Aniseikonia Scores and Vertical and Horizontal OCT Images in Idiopathic Epiretinal Membrane.
abstract: OBJECTIVE
  The purpose of this study was to identify the relationship between aniseikonia scores in the vertical and horizontal meridians and the foveal microstructure on vertical and horizontal spectral-domain optical coherence tomography (SD-OCT) in patients with idiopathic epiretinal membrane (ERM).
  
  
  METHODS
  All patients (n = 65) with unilateral ERM were examined, and the aniseikonia scores in the vertical (VAS) and horizontal (HAS) meridians were determined using the New Aniseikonia Test. Vertical and horizontal images passing through the fovea were obtained by axial SD-OCT in both eyes. The thicknesses of the ganglion cell layer + inner plexiform layer, inner nuclear layer (INL), and outer retinal layer were measured on the SD-OCT images, and color histograms were analyzed using Photoshop software.
  
  
  RESULTS
  Of the 65 ERM patients, 81.5% (53 patients) had macropsia. The VAS and HAS were equal in 52.8% (28 patients). Multiple regression analysis revealed significant correlations between the VAS and vertical INL thickness (R = 0.388, P = 0.001) and between the HAS and horizontal INL thickness (R = 0.349, P = 0.001). The difference between VAS and HAS was proportional to the ratio of the vertical INL thickness to horizontal INL thicknesses (R = 0.370, P < 0.001).
  
  
  CONCLUSIONS
  Eyes with ERM mostly presented macropsia. The aniseikonia scores in the vertical and horizontal meridians correlate well with INL thickness on the vertical and horizontal directions of SD-OCT images, respectively. Aniseikonia induced by ERM may be related to the INL thickening detected with SD-OCT.
authors.forename: Heeyoung
authors.initials: H
authors.lastname: Chung
authors.forename: Gisung
authors.initials: G
authors.lastname: Son
authors.forename: Duck Jin
authors.initials: DJ
authors.lastname: Hwang
authors.forename: Kyungmin
authors.initials: K
authors.lastname: Lee
authors.forename: Youngsook
authors.initials: Y
authors.lastname: Park
authors.forename: Joonhong
authors.initials: J
authors.lastname: Sohn
mesh_terms: D000328:Adult; D000368:Aged; D000839:Aniseikonia / Q000175:diagnosis* / Q000209:etiology; D019773:Epiretinal Membrane / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity