title: Hospitalized Heart Failure in the United States: Lessons Learned from Clinical Trial Populations.
abstract: Hospitalized heart failure (HHF) patients carry a prognosis comparable to many cancers and constitute more than 1 million hospital admissions annually in the United States. To date, North Americans have comprised a minority of those included in prior hospitalized HF trials and have been repeatedly shown to differ from patients in other areas of the world in terms of clinical characteristics, length of hospital stay, therapy utilization, and post-discharge outcomes. Recognizing the varying patient profiles and outcomes of North Americans enrolled in prior HHF trial programs is critical to optimizing design of future drug development programs and maximizing chances of bringing a novel therapeutic agent to the bedside.
authors.affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27705, USA. Electronic address: stephen.greene@dm.duke.edu.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Greene
authors.affiliation: Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, 211 East Ontario Street, Chicago, IL 60611, USA.
authors.forename: Lora
authors.initials: L
authors.lastname: AlKhawam
authors.affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27705, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Ambrosy
authors.affiliation: Heart & Vascular Center, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA.
authors.forename: Muthiah
authors.initials: M
authors.lastname: Vaduganathan
authors.affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27705, USA; Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Mentz
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D005260:Female; D006333:Heart Failure / Q000453:epidemiology / Q000628:therapy*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012042:Registries; D014481:United States / Q000453:epidemiology
keywords: Clinical trials; Heart failure; Hospitalization; North America