title: Relationship between cutaneous polyarteritis nodosa (cPAN) and macular lymphocytic arteritis (MLA): Blinded histologic assessment of 35 cPAN cases.
abstract: BACKGROUND
  Cutaneous polyarteritis nodosa (cPAN) is a skin medium vessel neutrophilic arteritis with livedo, nodules, and ulcerations. Macular lymphocytic arteritis (MLA) is a small arteritis with erythematous or pigmented macules and typical histologic features (a lymphocytic infiltrate, concentric fibrin ring, no disruption of the internal elastic lamina).
  
  
  OBJECTIVE
  We sought to assess the frequency of clinical and histologic features of MLA in patients with cPAN.
  
  
  METHODS
  This was a monocentric retrospective analysis of patients given the diagnosis of cPAN with blinded assessment of skin biopsy specimens.
  
  
  RESULTS
  All 35 patients included had an infiltrated livedo, nodules, or both. Ulceration was rare. Erythematous or pigmented lesions were present in 54% of patients. Predominantly lymphocytic arteritis, a paucity of neutrophils, concentric fibrin ring, and absence of internal lamina elastic disruption were present in 60%, 20%, 18%, and 23% of patients, respectively. Median follow-up was 11 years. None of the patients had systemic involvement, and 57% had a complete remission. The incidence of complete remission was not different between patients having a predominant lymphocyte infiltrate or few neutrophils.
  
  
  CONCLUSIONS
  This was a retrospective, monocentric study without a control group of patients with MLA.
  
  
  CONCLUSIONS
  Our data do not favor the classification of cPAN and MLA as distinct entities.
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Buffiere-Morgado
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Battistella
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Vignon-Pennamen
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Adèle
authors.initials: A
authors.lastname: de Masson
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Rybojad
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Petit
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Cordoliani
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Begon
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Flageul
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Alfred
authors.initials: A
authors.lastname: Mahr
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Bagot
authors.affiliation: University Paris Diderot, Sorbonne Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Dermatology, Pathology, and Internal Medicine Department, Saint Louis Hospital, Paris, France. Electronic address: jean-david.bouaziz@aphp.fr.
authors.forename: Jean-David
authors.initials: JD
authors.lastname: Bouaziz
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001167:Arteritis / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D001707:Biopsy, Needle; D015331:Cohort Studies; D016208:Databases, Factual; D003937:Diagnosis, Differential; D005260:Female; D005602:France; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D017678:Sex Distribution; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D055815:Young Adult
keywords: cutaneous periarteritis nodosa; lymphocytic thrombophilic arteritis; macular arteritis; macular lymphocytic arteritis; periarteritis nodosa; vasculitis