title: Development and function of Foxp3(+) regulatory T cells.
abstract: Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.
authors.affiliation: Centre for Kidney Research, Children's Hospital at Westmead, The University of Sydney, Sidney, New South Wales, Australia.
authors.forename: Yuan Min
authors.initials: YM
authors.lastname: Wang
authors.affiliation: Centre for Inflammatory Diseases, Monash University, Melbourne, Victoria, Australia.
authors.forename: Joanna
authors.initials: J
authors.lastname: Ghali
authors.affiliation: Centre for Kidney Research, Children's Hospital at Westmead, The University of Sydney, Sidney, New South Wales, Australia.
authors.forename: Geoff Yu
authors.initials: GY
authors.lastname: Zhang
authors.affiliation: Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Sidney, New South Wales, Australia.
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.affiliation: Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Sidney, New South Wales, Australia.
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Centre for Kidney Research, Children's Hospital at Westmead, The University of Sydney, Sidney, New South Wales, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Sawyer
authors.affiliation: Centre for Kidney Research, Children's Hospital at Westmead, The University of Sydney, Sidney, New South Wales, Australia.
authors.forename: Jimmy Jianheng
authors.initials: JJ
authors.lastname: Zhou
authors.affiliation: Centre for Kidney Research, Children's Hospital at Westmead, The University of Sydney, Sidney, New South Wales, Australia.
authors.forename: Dhanushka A
authors.initials: DA
authors.lastname: Hapudeniya
authors.affiliation: Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Sidney, New South Wales, Australia.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Sidney, New South Wales, Australia.
authors.forename: Qi
authors.initials: Q
authors.lastname: Cao
authors.affiliation: Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Sidney, New South Wales, Australia.
authors.forename: Guoping
authors.initials: G
authors.lastname: Zheng
authors.affiliation: Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Sidney, New South Wales, Australia.
authors.forename: David C
authors.initials: DC
authors.lastname: Harris
authors.affiliation: Centre for Kidney Research, Children's Hospital at Westmead, The University of Sydney, Sidney, New South Wales, Australia.
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Alexander
mesh_terms: D000818:Animals; D015551:Autoimmunity; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D019175:DNA Methylation; D051858:Forkhead Transcription Factors / Q000276:immunology* / Q000378:metabolism; D005921:Glomerulonephritis / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D007668:Kidney / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation; D010641:Phenotype; D051436:Renal Insufficiency, Chronic / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
keywords: Foxp3; Tregs; autoimmunity