title: BDNF-Deficient Mice Show Reduced Psychosis-Related Behaviors Following Chronic Methamphetamine.
abstract: BACKGROUND
  One of the most devastating consequences of methamphetamine abuse is increased risk of psychosis. Brain-derived neurotrophic factor has been implicated in both psychosis and neuronal responses to methamphetamine. We therefore examined persistent psychosis-like behavioral effects of methamphetamine in brain-derived neurotrophic factor heterozygous mice.
  
  
  METHODS
  Mice were chronically treated with methamphetamine from 6 to 9 weeks of age, and locomotor hyperactivity to an acute D-amphetamine challenge was tested in photocell cages after a 2-week withdrawal period.
  
  
  RESULTS
  Methamphetamine-treated wild-type mice, but not brain-derived neurotrophic factor heterozygous mice, showed locomotor sensitization to acute 3mg/kg D-amphetamine. Qualitative analysis of exploration revealed tolerance to D-amphetamine effects on entropy in methamphetamine-treated brain-derived neurotrophic factor heterozygous mice, but not wild-type mice.
  
  
  CONCLUSIONS
  Chronic methamphetamine exposure induces contrasting profiles of behavioral changes in wild-type and brain-derived neurotrophic factor heterozygous mice, with attenuation of behaviors relevant to psychosis in methamphetamine-treated brain-derived neurotrophic factor heterozygous mice. This suggests that brain-derived neurotrophic factor signalling changes may contribute to development of psychosis in methamphetamine users.
authors.affiliation: Florey Institute of Neuroscience and Mental Health Research, University of Melbourne, Victoria, Australia (Drs Manning and van den Buuse); Translational OCD Laboratory, Department of Psychiatry, University of Pittsburgh, PA (Dr Manning); Department of Psychiatry, University of California San Diego, La Jolla, CA (Dr Halberstadt); School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia (Dr van den Buuse).
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Manning
authors.affiliation: Florey Institute of Neuroscience and Mental Health Research, University of Melbourne, Victoria, Australia (Drs Manning and van den Buuse); Translational OCD Laboratory, Department of Psychiatry, University of Pittsburgh, PA (Dr Manning); Department of Psychiatry, University of California San Diego, La Jolla, CA (Dr Halberstadt); School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia (Dr van den Buuse).
authors.forename: Adam L
authors.initials: AL
authors.lastname: Halberstadt
authors.affiliation: Florey Institute of Neuroscience and Mental Health Research, University of Melbourne, Victoria, Australia (Drs Manning and van den Buuse); Translational OCD Laboratory, Department of Psychiatry, University of Pittsburgh, PA (Dr Manning); Department of Psychiatry, University of California San Diego, La Jolla, CA (Dr Halberstadt); School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia (Dr van den Buuse). m.vandenbuuse@latrobe.edu.au.
authors.forename: Maarten
authors.initials: M
authors.lastname: van den Buuse
mesh_terms: D019969:Amphetamine-Related Disorders / Q000150:complications / Q000378:metabolism*; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000172:deficiency* / Q000235:genetics; D000697:Central Nervous System Stimulants / Q000494:pharmacology / Q000633:toxicity*; D003913:Dextroamphetamine / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011605:Psychoses, Substance-Induced / Q000378:metabolism*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D003913:Dextroamphetamine
keywords: brain-derived neurotrophic factor; exploration; methamphetamine; psychosis