title: Language Differences at 12 Months in Infants Who Develop Autism Spectrum Disorder.
abstract: Little is known about early language development in infants who later develop autism spectrum disorder (ASD). We analyzed prospective data from 346 infants, some of whom were at high risk for developing ASD, to determine if language differences could be detected at 12 months of age in the infants who later were diagnosed with ASD. Analyses revealed lower receptive and expressive language scores in infants who later were diagnosed with ASD. Controlling for overall ability to understand and produce single words, a Rasch analysis indicated that infants who later developed ASD had a higher degree of statistically unexpected word understanding and production. At 12 months of age, quantitative and qualitative language patterns distinguished infants who later developed ASD from those who did not.
authors.affiliation: Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA. dlazenby@gmail.com.|Joint Base Elmendorf Richardson Hospital, 1234 Juneau Ave, Jber, AK, 99505, USA. dlazenby@gmail.com.
authors.forename: DeWayne C
authors.initials: DC
authors.lastname: Lazenby
authors.affiliation: Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.
authors.forename: Georgios D
authors.initials: GD
authors.lastname: Sideridis
authors.affiliation: Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.
authors.forename: Noelle
authors.initials: N
authors.lastname: Huntington
authors.affiliation: Utah State University, Logan, UT, USA.|Charlotte-Mecklenburg School System, Charlotte, NC, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Prante
authors.affiliation: University of New Mexico, Albuquerque, NM, USA.
authors.forename: Philip S
authors.initials: PS
authors.lastname: Dale
authors.affiliation: University of Calgary, Calgary, AB, Canada.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Curtin
authors.affiliation: University of Calgary, Calgary, AB, Canada.
authors.forename: Lisa
authors.initials: L
authors.lastname: Henkel
authors.affiliation: University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Jana M
authors.initials: JM
authors.lastname: Iverson
authors.affiliation: University of California, San Diego, CA, USA.
authors.forename: Leslie
authors.initials: L
authors.lastname: Carver
authors.affiliation: University of California, San Diego, CA, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Dobkins
authors.affiliation: University of California, San Diego, CA, USA.
authors.forename: Natacha
authors.initials: N
authors.lastname: Akshoomoff
authors.affiliation: Boston University, Boston, MA, USA.|Harvard University, Cambridge, MA, USA.
authors.forename: Daina
authors.initials: D
authors.lastname: Tagavi
authors.affiliation: Division of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.|Harvard Graduate School of Education, Cambridge, MA, USA.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Nelson
authors.affiliation: Boston University, Boston, MA, USA.
authors.forename: Helen
authors.initials: H
authors.lastname: Tager-Flusberg
mesh_terms: D000067877:Autism Spectrum Disorder / Q000150:complications* / Q000523:psychology*; D005260:Female; D006801:Humans; D007223:Infant; D007805:Language Development Disorders / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D011446:Prospective Studies
keywords: Autism spectrum disorder (ASD); Expressive/receptive vocabulary; Infant-sibling; Item response theory; MacArthur-Bates Communicative Developmental Inventories (CDI)