title: Acute Hepatitis E Viral Infection in Pregnancy and Maternal Morbidity.
abstract: OBJECTIVE
  To determine the maternal morbidity in pregnant women with acute hepatitis E viral infection.
  
  
  METHODS
  Observational, cross-sectional study.
  
  
  METHODS
  Departments of Obstetrics and Gynaecology and Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Red Crescent General Hospital and Saint Elizabeth Hospital, Hyderabad, from January 2011 to December 2013.
  
  
  METHODS
  The study population was pregnant women with acute hepatitis E infection confirmed by ELIZA technique. Pregnant women with other hepatic viral infections were excluded. All medical and obstetric conditions, and mortality were noted on the predesigned proforma.
  
  
  RESULTS
  Out of the total 45 admitted pregnant women with hepatitis E viral infection, 22 women (48.9%) had severe morbidity. The most common were hepatic coma in 8 (36.36%) cases and disseminated intravascular coagulation in 14 (63.63%) cases. Highest mortality rate was seen in women with hepatic coma (100%), while in those with disseminated intravascular coagulation, one out of the 14 cases (7.14%) died.
  
  
  CONCLUSIONS
  The acute viral hepatitis E infection in pregnant women is associated with maternal morbidities and high mortality rate.
authors.affiliation: Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences, Jamshoro.
authors.forename: Meharun-Nissa
authors.initials: MN
authors.lastname: Khaskheli
authors.affiliation: Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences, Jamshoro.
authors.forename: Shahla
authors.initials: S
authors.lastname: Baloch
authors.affiliation: Department of Radiology, Liaquat University of Medical and Health Sciences, Jamshoro.
authors.forename: Aneela
authors.initials: A
authors.lastname: Sheeba
authors.affiliation: Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro.
authors.forename: Sarmad
authors.initials: S
authors.lastname: Baloch
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006470:Hemorrhage / Q000453:epidemiology / Q000209:etiology; D016751:Hepatitis E / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D016752:Hepatitis E virus / Q000302:isolation & purification*; D006801:Humans; D007565:Jaundice / Q000209:etiology; D017114:Liver Failure, Acute / Q000453:epidemiology* / Q000209:etiology; D009017:Morbidity; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D011256:Pregnancy Outcome; D012959:Socioeconomic Factors; D055815:Young Adult