title: It's Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles.
abstract: Paradigm-shifting advances have revealed that diverse membraneless organelles originate via liquid-liquid phase separation, but how their distinct structural and functional milieux are specified is not understood. Recent work elucidates that RNA governs the biophysical characteristics of liquid droplets formed by RNA-binding proteins with low-complexity domains and can decelerate pathogenic fibrillogenesis.
authors.affiliation: Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: jshorter@mail.med.upenn.edu.
authors.forename: James
authors.initials: J
authors.lastname: Shorter
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism* / Q000473:pathology; D004548:Elasticity; D006801:Humans; D015388:Organelles / Q000737:chemistry* / Q000378:metabolism; D066263:Protein Aggregation, Pathological / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D014783:Viscosity
chemical_list: D016601:RNA-Binding Proteins; D012313:RNA