title: A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes.
abstract: A cooperative Cu/Pd-catalyzed asymmetric three-component reaction of styrenes, B2(pin)2, and allyl carbonates was reported. This reaction, in the presence of chiral CuOAc/SOP and achiral Pd(dppf)Cl2 catalysts, occurs smoothly with high enantioselectivities (up to 97% ee) . The allylboration products, which contain alkene (or diene) unite and alkylboron group, are easily functionalized. The utility of this protocol was demonstrated through the synthesis of an antipsychotic drug, (-)-preclamol.
authors.affiliation: Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jia
authors.affiliation: Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.affiliation: Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Yazhou
authors.initials: Y
authors.lastname: Lou
authors.affiliation: Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Yin
authors.affiliation: Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001880:Boranes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000498:Allyl Compounds; D001880:Boranes; D009942:Organometallic Compounds; D010880:Piperidines; D010165:Palladium; D003300:Copper; C026539:preclamol