title: Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5%) following Repeated Intramuscular Administrations in Sheep and Goats.
abstract: The comparative pharmacokinetic profile of cefquinome was studied in sheep and goats following repeated intramuscular (IM) administrations of 2 mg/kg body weight. Cefquinome concentrations in serum were determined by microbiological assay technique using Micrococcus luteus (ATCC 9341) as test organism. Following intramuscular injection of cefquinome in sheep and goats, the disposition curves were best described by two-compartment open model in both sheep and goats. The pharmacokinetics of cefquinome did not differ significantly between sheep and goats; similar intramuscular dose rate of cefquinome should therefore be applicable to both species. On comparing the data of serum levels of repeated intramuscular injections with first intramuscular injection, it was revealed that repeated intramuscular injections of cefquinome have cumulative effect in both species sheep and goats. The in vitro serum protein-binding tendency was 15.65% in sheep and 14.42% in goats. The serum concentrations of cefquinome along 24 h after injection in this study were exceeding the MICs of different susceptible microorganisms responsible for serious disease problems. These findings indicate successful use of cefquinome in sheep and goats.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of El-Sadat City, Minoufiya 32897, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Hewaity
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of El-Sadat City, Minoufiya 32897, Egypt.
authors.forename: Amera
authors.initials: A
authors.lastname: Abd El Latif
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Soliman
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubia 13736, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Aboubakr