title: Recidivism in Liver Transplant Recipients With Alcoholic Liver Disease: Analysis of Demographic, Psychosocial, and Histology Features.
abstract: OBJECTIVE
  Liver transplant for alcoholic liver disease requires identifying potential recipients at risk for recidivism. We sought to identify risk factors for recidivism and survival in recipients of liver transplant with alcoholic liver disease.
  
  
  METHODS
  Demographic, psychosocial, and histology features were evaluated as risk factors toward harmful recidivism in 148 recipients of liver transplant with alcoholic liver disease.
  
  
  RESULTS
  Based on the univariate analysis using Cox proportional hazards model, duration of alcohol abstinence 6 months (HR 3.74; P = .011, 95% CI: 1.36-10.3), non-alcohol related criminal history (HR 3.18; P = .032, 95% CI: 1.1-9.15), support from immediate family (HR 0.24; P = .0061, 95% CI: 0.09-0.67), and active smoking at the time of liver transplant (HR 2.74; P = .041, 95% CI: 1-7.53) were identified as significant predictors for recidivism. Older patients had less likelihood of alcohol relapse (HR 0.91; P = .0014, 95% CI: 0.87-0.97) on univariate model. In multivariate model older patients (HR 0.91; P = .004, 95% CI: 0.86-0.97) and patients who have immediate family support (HR 0.27; P = .012, 95% CI: 0.10-0.76) predicated against recidivism. Suggestive features of alcoholic hepatitis on liver explant did not predict recidivism or long-term survival. One-, three-, and five-year patient survival rates estimated by Kaplan-Meier survival model in the recipients that remained abstinent were 95%, 87%, and 80%, compared with 87%, 49%, and 49% for the recipients with recidivism (P = .001).
  
  
  CONCLUSIONS
  Recidivism is associated with earlier death after liver transplant. Older recipients and patients with immediate family support are less likely to have alcohol relapse, and have better long-term survival.
authors.affiliation: Department of Transplantation, Methodist University Hospital Transplant Institute/University of Tennessee Health Sciences Center, Memphis, TN, USA.
authors.forename: Sanjaya K
authors.initials: SK
authors.lastname: Satapathy
authors.forename: James D
authors.initials: JD
authors.lastname: Eason
authors.forename: Satheesh
authors.initials: S
authors.lastname: Nair
authors.forename: Oleksandra
authors.initials: O
authors.lastname: Dryn
authors.forename: Pamela B
authors.initials: PB
authors.lastname: Sylvestre
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kocak
authors.forename: Jason M
authors.initials: JM
authors.lastname: Vanatta
mesh_terms: D000367:Age Factors; D064829:Alcohol Abstinence; D018572:Disease-Free Survival; D005195:Family Relations; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018579:Patient Selection; D016016:Proportional Hazards Models; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012944:Social Support; D013997:Time Factors; D016896:Treatment Outcome