title: Gold nanorods contained polyvinyl alcohol/chitosan nanofiber matrix for cell imaging and drug delivery.
abstract: Gold nanorods (AuNRs) that contained polyvinyl alcohol/chitosan (PVA/CS) hybrid nanofibers with dual functions are successfully fabricated by a simple electrospinning method. The results of transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy dispersive X-ray (EDX) spectroscopy indicate that AuNRs are indeed encapsulated into the PVA/CS hybrid nanofibers. FTIR spectra results demonstrate that the chemical structures of PVA and CS are not affected when the AuNRs are introduced into the fibers. In vitro cytotoxicity test reveals that the hybrid fibers involving AuNRs are completely biocompatible. The as-prepared fibers can be used as a carrier for anticancer agent doxorubicin (DOX), and the drug is delivered into the cell nucleus. The AuNRs and DOX incorporated fibers are effective for inhibiting the growth and proliferation of ovary cancer cells and they can also be used as the cell imaging agent due to the unique optical properties of AuNRs. The nanofiber matrix combining two functions of cell imaging and drug delivery may be of great application potential in biomedical-related areas.
authors.affiliation: College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, PR China. Electronic address: yaney359@126.com.
authors.forename: Eryun
authors.initials: E
authors.lastname: Yan
authors.affiliation: College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, PR China; College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Minglu
authors.initials: M
authors.lastname: Cao
authors.affiliation: College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Hao
authors.affiliation: College of Food and Biological Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Shichun
authors.initials: S
authors.lastname: Pei
authors.affiliation: College of Food and Biological Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Gao
authors.affiliation: College of Food and Biological Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, PR China.
authors.forename: Zhuanfang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, PR China. Electronic address: zhdqing@163.com.
authors.forename: Deqing
authors.initials: D
authors.lastname: Zhang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence; D057139:Nanofibers / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D059010:Single-Cell Analysis
chemical_list: D004337:Drug Carriers; D006046:Gold; D011142:Polyvinyl Alcohol; D048271:Chitosan
keywords: Chitosan; Electrospinning; Gold nanorods; Nanofibers; Polyvinyl alcohol