title: Anti-Mycobacterium tuberculosis activity of antituberculosis drugs and amoxicillin/clavulanate combination.
abstract: We report the in vitro drugs interaction by the resazurin drugs combination microtiter assay (REDCA) of amoxicillin (AMO)/clavulanate (CLAV) with isoniazid (INH), ethambutol (EMB), and rifampicin (RIF) against susceptible and resistant Mycobacterium tuberculosis isolates. The addition of AMO/CLAV to classical antituberculosis drugs should be explored as a promising alternative for the treatment of resistant tuberculosis (TB).
authors.affiliation: Postgraduate Program in Health Sciences, State University of Maringá, 87020-900, Maringá, Paraná, Brazil.
authors.forename: Aline Daniele Furlan
authors.initials: AD
authors.lastname: Pagliotto
authors.affiliation: Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá, Paraná, Brazil.
authors.forename: Katiany Rizzieri
authors.initials: KR
authors.lastname: Caleffi-Ferracioli
authors.affiliation: Postgraduate Program in Biosciences and Physiopathology, State University of Maringá, 87020-900, Maringá, Paraná, Brazil.
authors.forename: Mariana Aparecida
authors.initials: MA
authors.lastname: Lopes
authors.affiliation: Postgraduate Program in Biosciences and Physiopathology, State University of Maringá, 87020-900, Maringá, Paraná, Brazil.
authors.forename: Vanessa Pietrowski
authors.initials: VP
authors.lastname: Baldin
authors.affiliation: School of Pharmaceutical Sciences, Department of Biological Sciences, Paulista State University, Araraquara, 14800-901, São Paulo, Brazil.
authors.forename: Clarice Queico Fujimura
authors.initials: CQ
authors.lastname: Leite
authors.affiliation: School of Pharmaceutical Sciences, Department of Biological Sciences, Paulista State University, Araraquara, 14800-901, São Paulo, Brazil.
authors.forename: Fernando Rogério
authors.initials: FR
authors.lastname: Pavan
authors.affiliation: Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá, Paraná, Brazil.
authors.forename: Regiane Bertin de Lima
authors.initials: RB
authors.lastname: Scodro
authors.affiliation: Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá, Paraná, Brazil.
authors.forename: Vera Lúcia Dias
authors.initials: VL
authors.lastname: Siqueira
authors.affiliation: Postgraduate Program in Health Sciences, State University of Maringá, 87020-900, Maringá, Paraná, Brazil; Department of Clinical Analysis and Biomedicine, State University of Maringá, 87020-900, Maringá, Paraná, Brazil; Postgraduate Program in Biosciences and Physiopathology, State University of Maringá, 87020-900, Maringá, Paraná, Brazil. Electronic address: rfressatticardoso@gmail.com.
authors.forename: Rosilene Fressatti
authors.initials: RF
authors.lastname: Cardoso
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D019818:Clavulanic Acid / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004977:Ethambutol / Q000494:pharmacology*; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D010078:Oxazines / Q000032:analysis; D012293:Rifampin / Q000494:pharmacology*; D014966:Xanthenes / Q000032:analysis
chemical_list: D000995:Antitubercular Agents; D010078:Oxazines; D014966:Xanthenes; C005843:resazurin; D019818:Clavulanic Acid; D000658:Amoxicillin; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin
keywords: Mycobacterium tuberculosis; amoxicillin/clavulanate; checkerboard; synergism; tuberculosis