title: [Effect of supplementation with a single dose of vitamin D in children with cerebral palsy. Preliminary randomised controlled study].
abstract: BACKGROUND
  Children with cerebral palsy (CP) have an increased risk of vitamin D (VD) deficiency. Although there are many studies on VD and CP, there is limited information about VD supplementation in these patients.
  
  
  OBJECTIVE
  To evaluate the effect of supplementation with a single dose of VD on the plasma concentrations of 25-hydroxy-vitamin-D (25OHD) in children with CP.
  
  
  METHODS
  Prospective-randomised-controlled-trial, including 30 Chilean children (19 males) with CP, median age 9.9 years (6.2-13.5). Clinical and biochemical variables including 25OHD, were recorded (time 0 and 8 weeks). Patients were allocated to the supplemented (S) group receiving 100,000 IU oral D3 at baseline, and compared with the placebo (P) group.
  
  
  RESULTS
  Among clinical features are highlighted: gastrostomy (60%), underweight (30%), bed-ridden (93.3%), antiepileptic drugs (70%), and 43.3% used VD metabolism inducing antiepileptics. Baseline biochemical measurements were normal. The 25OHD was insufficient in 4/30 and deficient in 6/30. 25OHD levels were not associated with the variables studied. Eight patients completed the study in the S group, and 10 in P group. The placebo and supplementation groups had no significant difference in baseline variables. Serum calcium, phosphate, and alkaline phosphatase levels at 8 weeks were normal in both groups, with no statistically significant differences. 25OHD in the P group was normal in 6/10, and insufficient+deficient in 4/10, and the S group was normal in all (8/8) (exact Fisher test P=.07).
  
  
  CONCLUSIONS
  A single dose of 100,000 IU VD could normalise the concentrations of 25OHD after 8 weeks of supplementation in Children with CP, but more studies are required to confirm these results.
authors.affiliation: Pediatra, Nutriólogo, Departamento de Pediatría, Facultad de Medicina Campus Centro, Universidad de Chile, Santiago de Chile, Chile; Pediatra, Nutriólogo, División de Pediatría, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile. Electronic address: catalinaleroy@yahoo.es.
authors.forename: Catalina
authors.initials: C
authors.lastname: Le Roy
authors.affiliation: Alumna 6.° año de Medicina, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile.
authors.forename: Martina
authors.initials: M
authors.lastname: Meier
authors.affiliation: Neuróloga Infantil, Servicio Neuropsiquiatría Infantil, Hospital Clínico San Borja-Arriarán, Santiago de Chile, Chile; Neuróloga Infantil, Departamento de Pediatría, Facultad de Medicina Campus Centro, Universidad de Chile, Santiago de Chile, Chile.
authors.forename: Scarlett
authors.initials: S
authors.lastname: Witting
authors.affiliation: Bioquímico, Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile.
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez-Bravo
authors.affiliation: Bioquímico, Laboratorio Inmunología, Hospital Clínico San Borja-Arriarán, Santiago de Chile, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Solano
authors.affiliation: Pediatra, Nutriólogo, Departamento de Pediatría, Facultad de Medicina Campus Centro, Universidad de Chile, Santiago de Chile, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Castillo-Durán
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D002547:Cerebral Palsy / Q000150:complications / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002677:Chile; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D010710:Phosphates / Q000097:blood; D011446:Prospective Studies; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014808:Vitamin D Deficiency / Q000188:drug therapy* / Q000209:etiology
chemical_list: D010710:Phosphates; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: Cerebral palsy; Children; Niños; Parálisis cerebral; Suplementación; Supplementation; Vitamin D; Vitamina D