title: Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration.
abstract: Controlled drug release is a process in which a predetermined amount of drug is released for longer period of time, ranging from days to months, in a controlled manner. In this study, novel drug delivery devices were fabricated via blend electrospinning and coaxial electrospinning using poly lactic glycolic acid (PLGA), gum tragacanth (GT) and tetracycline hydrochloride (TCH) as a hydrophilic model drug in different compositions and their performance as a drug carrier scaffold was evaluated. Scanning electron microscopy (SEM) results showed that fabricated PLGA, blend PLGA/GT and core shell PLGA/GT nanofibers had a smooth and bead-less morphology with the diameter ranging from 180 to 460 nm. Drug release studies showed that both the fraction of GT within blend nanofibers and the core-shell structure can effectively control TCH release rate from the nanofibrous membranes. By incorporation of TCH into core-shell nanofibers, drug release was sustained for 75 days with only 19% of burst release within the first 2h. The prolonged drug release, together with proven biocompatibility, antibacterial and mechanical properties of drug loaded core shell nanofibers make them a promising candidate to be used as drug delivery system for periodontal diseases.
authors.affiliation: Textile Engineering Group, Department of Engineering, University of Bonab, Bonab, Iran.
authors.forename: Marziyeh
authors.initials: M
authors.lastname: Ranjbar-Mohammadi
authors.affiliation: Mechanical Engineering Department, National University of Singapore, Singapore; Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore.
authors.forename: M
authors.initials: M
authors.lastname: Zamani
authors.affiliation: Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore. Electronic address: nnimpp@nus.edu.sg.
authors.forename: M P
authors.initials: MP
authors.lastname: Prabhakaran
authors.affiliation: Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran. Electronic address: hajirb@aut.ac.ir.
authors.forename: S Hajir
authors.initials: SH
authors.lastname: Bahrami
authors.affiliation: Mechanical Engineering Department, National University of Singapore, Singapore; Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore.
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishna
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D049109:Cell Proliferation; D002478:Cells, Cultured; D004337:Drug Carriers / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods*; D005347:Fibroblasts; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology; D010316:Particle Size; D010518:Periodontitis; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D013752:Tetracycline / Q000737:chemistry* / Q000494:pharmacology; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D014144:Tragacanth / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D014144:Tragacanth; D013752:Tetracycline
keywords: Coaxial electrospinning; Electrospun nanofibers; Gum tragacanth; PLGA; Periodontal regeneration