title: [First experience of a polyurethane foam composition "Locus" use to stop intra-abdominal hemorrhage as a result of liver damage of V degree. (An experimental study)].
abstract: Today self-expanding polymers are considered as the most promising as means for intracavitary hemostasis in case of continuing bleeding after trauma. Testing of domestic open-cell polyurethane foam composition "Locus" was carried out on the developed experimental model simulating liver trauma of V degree. After damaging 6 experimental rabbits were injected intraperitoneally with 80 ml of the composition. 5 experimental rabbits were included into to control group (haemostatic agent was not given). Estimated blood loss was 111-124 ml. The two-hour survival rate didn't differ significantly: 3 animals survived in the experimental group; 2 animal survived in the control. Despite the 3-4-fold widening of the foam, due to open cells it absorbed 72.6 +/- 8.3 g of blood. Thus, open-cell polyurethane foam intraperitoneal administration of the composition didn't provide a temporary intra-abdominal hemostasis in liver. In order to enhance the hemostatic effect it requires changing the formulation of the polyurethane composition. For a more accurate assessment of the results it is neccessary to perform additional researches on larger animals.
authors.forename: V A
authors.initials: VA
authors.lastname: Reva
authors.forename: M A
authors.initials: MA
authors.lastname: Litinskii
authors.forename: A V
authors.initials: AV
authors.lastname: Denisov
authors.forename: M V
authors.initials: MV
authors.lastname: Sokhranov
authors.forename: S Yu
authors.initials: SY
authors.lastname: Telitskii
authors.forename: I M
authors.initials: IM
authors.lastname: Samokhvalov
mesh_terms: D000007:Abdominal Injuries / Q000628:therapy*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy*; D006489:Hemostatic Techniques; D008099:Liver / Q000293:injuries*; D008297:Male; D011140:Polyurethanes / Q000494:pharmacology*; D011817:Rabbits; D015599:Trauma Severity Indices; D016896:Treatment Outcome
chemical_list: D011140:Polyurethanes; C028279:polyurethane foam