title: Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention.
abstract: Posterior capsule opacification (PCO) is one of the main reasons for loss of vision again after cataract surgery. In this study, intraocular lenses were modified with indocyanine green (ICG) and sealed up with PLGA to form long-term intraocular implants (ICG-IOL). When triggered by laser, ICG-IOL would induce photodynamic therapy (PDT). In-vitro cell viability assay and scratch wound healing assay demonstrated that ICG-IOL could effectively inhibit HLEpiC proliferation and migration without causing damage to the cells far away from it. Laser attenuation test indicated that ICG-IOL could be applied in vivo. In-vivo pharmacodynamics and safety study showed that ICG-IOL could significantly prevent the occurrence of PCO and was safe for intraocular normal tissue. All these results suggested that ICG-IOL would be a very promising candidate for PCO prevention.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510000 People's Republic of China.
authors.forename: Wenyong
authors.initials: W
authors.lastname: Huang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Lei
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors.forename: Yuanfeng
authors.initials: Y
authors.lastname: He
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors.forename: Mina
authors.initials: M
authors.lastname: Yan
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: zhaocs@mail.sysu.edu.cn.
authors.forename: Chunshun
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000818:Animals; D058442:Capsule Opacification / Q000517:prevention & control*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D007208:Indocyanine Green / Q000494:pharmacology / Q000627:therapeutic use; D019344:Lactic Acid / Q000494:pharmacology / Q000627:therapeutic use; D007834:Lasers; D019654:Lens Implantation, Intraocular / Q000379:methods*; D010778:Photochemotherapy / Q000379:methods*; D011100:Polyglycolic Acid / Q000494:pharmacology / Q000627:therapeutic use; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011474:Prosthesis Design / Q000379:methods*; D011817:Rabbits; D051381:Rats
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D007208:Indocyanine Green
keywords: Indocyanine green; Intraocular implant; Laser-triggered; Photodynamic therapy; Posterior capsule opacification