title: Pseudoangiomatous stromal hyperplasia causing massive breast enlargement.
abstract: Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign mesenchymal proliferative process, initially described by Vuitch et al. We report an unusual case of a 46-year-old woman who presented with a 6-week history of bilateral massive, asymmetrical, painful enlargement of her breasts, without a history of trauma. On clinical examination, both breasts were markedly enlarged and oedematous, but there were no discrete palpable masses. Preoperative image-guided core biopsies and surgery showed PASH. PASH is increasingly recognised as an incidental finding on image-guided core biopsy performed for screen detected lesions. There are a few reported cases of PASH presenting as rapid breast enlargement. In our case, the patient presented with painful, asymmetrical, massive breast enlargement. Awareness needs to be raised of this entity as a differential diagnosis in massive, painful breast enlargement.
authors.affiliation: Department of Radiology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
authors.forename: Anita Geraldine
authors.initials: AG
authors.lastname: Bourke
authors.affiliation: Department of Radiology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Tiang
authors.affiliation: Department of Pathwest, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
authors.forename: Nathan
authors.initials: N
authors.lastname: Harvey
authors.affiliation: Department of Pathwest, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: McClure
mesh_terms: D000798:Angiomatosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D001940:Breast / Q000002:abnormalities* / Q000473:pathology; D001941:Breast Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006984:Hypertrophy / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D059373:Mastodynia / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged