title: Correlation of narrow band imaging endoscopy and histopathology in the diagnosis of nonerosive reflux disease.
abstract: Background /Aim: Narrow band imaging (NBI) is a novel, innovative high-resolution endoscopic technique, which utilizes spectral narrow band filter for the visualization of mucosal patterns and microvasculature. Nonerosive reflux disease (NERD) is a type of gastroesophageal reflux disease (GERD) and it is characterized by reflux symptoms without mucosal breaks on white light endoscopy (WLE). Biopsies from distal esophagus of GERD patients show group of histologic features such as basal cell hyperplasia, elongation of lamina propria papillae, and inflammatory cells. The present study was undertaken to evaluate diagnostic utility of NBI endoscopy and biopsy study in NERD patients and also to correlate NBI endoscopy findings with histologic features of GERD.
  
  
  METHODS
  A total of 71 cases of NERD having symptom score more than 10 and those not having erosion on WLE were recruited prospectively and underwent NBI endoscopic examination. Two mucosal biopsies were taken at 3 cm above the squamocolumnar junction.
  
  
  RESULTS
  Histologic features of GERD were seen in 50 (70.4%) out of 71 cases. No significant correlation between NBI endoscopic findings with histologic features of GERD was found.
  
  
  CONCLUSIONS
  The present study showed that histopathologic evaluation of distal esophageal mucosa has promising diagnostic value over NBI endoscopy in NERD patients. Use of newly introduced NBI technique requires tremendous familiarity for the detection of the cases of NERD, which show histologic features of GERD.
authors.affiliation: Department of Pathology, Dhanalakshmi Srinivasan Medical College and Hospital, Siruvachur, Perambalur, Tamil Nadu, India.
authors.forename: P
authors.initials: P
authors.lastname: Arul
authors.forename: B
authors.initials: B
authors.lastname: Vinoth
authors.forename: Thomas
authors.initials: T
authors.lastname: Alexander
authors.forename: Manjiri
authors.initials: M
authors.lastname: Phansalkar
authors.forename: Somanath
authors.initials: S
authors.lastname: Padhi
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D016145:Endoscopy, Digestive System / Q000191:economics / Q000379:methods*; D004947:Esophagus / Q000473:pathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000191:economics / Q000473:pathology; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000098:blood supply / Q000473:pathology; D062048:Narrow Band Imaging / Q000191:economics / Q000379:methods*; D015995:Prevalence; D011446:Prospective Studies; D012907:Smoking / Q000473:pathology