title: [Combination therapy with fluconazole and other QTc-prolonging drugs increase the QTc interval].
abstract: Several drugs have a QTc-prolonging effect and are metabolized by CYP3A4. The combination of QTc-prolonging drugs may act additive of the QTc interval. The risk increases additionally by co-administration of a CYP3A4-inhibiting substrate. This case report describes an incident with QTc prolongation which was probably caused by an interaction induced by a combination of amiodarone, clarithromycin and the CYP3A4-inhibitor fluconazole.
authors.affiliation: buch.tinabuch@gmail.com.
authors.forename: Tina
authors.initials: T
authors.lastname: Buch
authors.forename: Stig Ejdrup
authors.initials: SE
authors.lastname: Andersen
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017291:Clarithromycin / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000009:adverse effects; D004347:Drug Interactions; D004562:Electrocardiography; D015725:Fluconazole / Q000009:adverse effects* / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male
chemical_list: D000889:Anti-Arrhythmia Agents; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D015725:Fluconazole; D017291:Clarithromycin; D000638:Amiodarone