title: Carbon-Dot-Based Nanosensors for the Detection of Intracellular Redox State.
abstract: Carbon-dot-based nanosensors are prepared through sequentially assembling a polymer/carbon dot multilayer shell on mesoporous silica nanoparticles with different crosslinking densities of disulfide bonds; they can be utilized to evaluate the gluthathione (GSH) concentration. In vitro cell assays demonstrate the feasibility of using such nanosensors in evaluating the intracellular redox state of different cells.
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Yefei
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Chemistry, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Wuli
authors.initials: W
authors.lastname: Yang
mesh_terms: D002244:Carbon / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry; D005978:Glutathione / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation*; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D004220:Disulfides; D011108:Polymers; D002244:Carbon; D012822:Silicon Dioxide; D005978:Glutathione
keywords: carbon dots; disulfide bonds; glutathione nanosensors; redox states