title: Immunogenicity of Hepatitis B Vaccine in HIV Exposed Uninfected Infants.
abstract: There is paucity of knowledge about the immunogenicity of vaccines in infants who have been exposed to HIV in-utero but have remained uninfected. The authors studied the immunogenicity of 3 doses of recombinant hepatitis B vaccine at 6,10,14 wk of age in HIV exposed but uninfected (HEU) infants. After 3 mo of last dose of the vaccine, out of 26 infants, 23 (89.5 %) infants were found to be responders (Anti HBs IgG titres ≥ 10 mIU/ml) and 3 (11.5 %) babies remained non responders (Anti HBs IgG titres < 10 mIU/ml). The proportion of babies who were non responders were higher when compared to similar studies done on unexposed and uninfected infants, suggesting a poorer immunogenicity of hepatitis B vaccine in these infants.
authors.affiliation: Department of Pediatrics, M. L. N. Medical College, Allahabad, Uttar Pradesh, India.
authors.forename: Dharmendra K
authors.initials: DK
authors.lastname: Singh
authors.affiliation: Department of Pediatrics, M. L. N. Medical College, Allahabad, Uttar Pradesh, India.
authors.forename: Rajnish
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Department of Pediatrics, M. L. N. Medical College, Allahabad, Uttar Pradesh, India. ruchiraialld@gmail.com.|S. N. Children Hospital, Church Lane, Allahabad, 211002, Uttar Pradesh, India. ruchiraialld@gmail.com.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Rai
authors.affiliation: Department of Pediatrics, M. L. N. Medical College, Allahabad, Uttar Pradesh, India.
authors.forename: Manisha
authors.initials: M
authors.lastname: Maurya
authors.affiliation: Department of Microbiology, M. L. N. Medical College, Allahabad, Uttar Pradesh, India.
authors.forename: Anudita
authors.initials: A
authors.lastname: Bhargava
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D018023:HIV Seronegativity / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D007194:India; D007223:Infant; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D011446:Prospective Studies; D013223:Statistics as Topic
chemical_list: D017325:Hepatitis B Vaccines
keywords: HBV; HIV exposed; Seroprotection