title: Effect of luteoin in delaying cataract in STZ-induced diabetic rats.
abstract: Luteolin, a flavonoid rich in many plants, has shown various pharmacological effects including anti-inflammation, anti-oxidant, anti-tumor, cardioprotective and neuroprotective properties. At present, inflammation and oxidative stress have been recognized to be two important contributing factors to the development of diabetic cataract. The aim of this study is to investigate the effects of luteolin on diabetes-induced oxidative stress and inflammation in the lens of rats. A diabetic rat model was induced by intraperitoneally giving streptozotocin at a dosage of 60 mg/kg, and then the rats were treated by orally administration of luteolin 25, 50 and 100 mg/kg for 12 weeks. The results showed that luteolin administration could increase the antioxidant capacity such as glutathione (GSH) and glutathione peroxidase (GPx) activity, and decreased malondialdehyde (MDA) level in the lens of diabetic rats. Luteolin also inhibited diabetes-induced elevation of interleukin-1 beta (IL-1β), vascular endothelial growth factor and nuclear factor-κB (NF-κB) mRNA and protein expression in lens. Moreover, in the high dose group (100 mg/kg), lens GSH level was decreased to normal compared to control group. The degree of oxidative and inflammatory damage was significantly reduced in luteolin-treated rats. These data suggested that luteolin can be an effective protection candidate of diabetes-induced lens neurodegeneration by inhibiting the levels of inflammatory mediators and oxidative stress.
authors.affiliation: Department of Ophthalmology, The People's Hospital of Binzhou City, Binzhou, 256610, Shandong Province, China. chenybio@126.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, The People's Hospital of Binzhou City, Binzhou, 256610, Shandong Province, China.
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Sun
authors.affiliation: Department of Ophthalmology, The People's Hospital of Binzhou City, Binzhou, 256610, Shandong Province, China.
authors.forename: Hong-E
authors.initials: HE
authors.lastname: Lu
authors.affiliation: Department of Ophthalmology, The People's Hospital of Binzhou City, Binzhou, 256610, Shandong Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, The People's Hospital of Binzhou City, Binzhou, 256610, Shandong Province, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Fan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002386:Cataract / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D047311:Luteolin / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D013311:Streptozocin; D047311:Luteolin
keywords: Cataract; Diabetes; Inflammation; Luteolin; Oxidative stress