title: Acrylic Resin Cytotoxicity for Denture Base--Literature Review.
abstract: Acrylic resin is a widely used material in clinical practice, and a satisfactory biocompatibility is essential. When the resin polymerization reaction is incomplete, residual monomers are released into the oral cavity. The aim of this study was to evaluate, through a literature review, the cytotoxicity caused by the denture base acrylic resin used, and its components. The selection of published studies was performed on the Pubmed database from January 2008 to July 2013. The keywords used were: "cytotoxicity and acrylic resins", "cytotoxicity and denture base resins" and "cytotoxicity and oral prosthesis". Inclusion criteria were: in vitro studies and literature reviews published in English that evaluated the acrylic resin cytotoxicity for denture base and its components. Studies with no reference to the search strategy were excluded. A total of 182 articles were found. Among these, only 13 were included for writing this review. The MTT test is the most common test used to evaluate acrylic resin cytotoxicity. Auto-polymerized resin is more cytotoxic than heat-polymerized resin because of its higher quantity of residual monomers which cause cell and tissue changes in the oral mucosa. However, more studies are necessary for the development of biocompatible materials.
authors.affiliation: 1st Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP - Universidade Estadual Paulista "Júlio de Mesquita Filho", Araçatuba, Sao Paulo, Brazil.
authors.forename: Marcelo C
authors.initials: MC
authors.lastname: Goiato
authors.affiliation: 1st Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP - Universidade Estadual Paulista "Júlio de Mesquita Filho", Araçatuba, Sao Paulo, Brazil.
authors.forename: Emily
authors.initials: E
authors.lastname: Freitas
authors.affiliation: 1st Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP - Universidade Estadual Paulista "Júlio de Mesquita Filho", Araçatuba, Sao Paulo, Brazil.
authors.forename: Daniela
authors.initials: D
authors.lastname: dos Santos
authors.affiliation: Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP - Universidade Estadual Paulista "Júlio de Mesquita Filho", Araçatuba, Sao Paulo, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: de Medeiros
authors.affiliation: Department of Dental Materials and Prosthodontics, Aracatuba Dental School, UNESP - Universidade Estadual Paulista "Júlio de Mesquita Filho", Araçatuba, Sao Paulo, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Sonego
mesh_terms: D000818:Animals; D001681:Biological Assay; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003819:Denture Bases / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D019904:Polymethyl Methacrylate / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D018675:Toxicity Tests / Q000379:methods
chemical_list: D019904:Polymethyl Methacrylate