title: RelB activation in anti-inflammatory decidual endothelial cells: a master plan to avoid pregnancy failure?
abstract: It is known that excessive inflammation at fetal-maternal interface is a key contributor in a compromised pregnancy. Female genital tract is constantly in contact with microorganisms and several strategies must be adopted to avoid pregnancy failure. Decidual endothelial cells (DECs) lining decidual microvascular vessels are the first cells that interact with pro-inflammatory stimuli released into the environment by microorganisms derived from gestational tissues or systemic circulation. Here, we show that DECs are hypo-responsive to LPS stimulation in terms of IL-6, CXCL8 and CCL2 production. Our results demonstrate that DECs express low levels of TLR4 and are characterized by a strong constitutive activation of the non-canonical NF-κB pathway and a low responsiveness of the canonical pathway to LPS. In conclusion, DECs show a unique hypo-responsive phenotype to the pro-inflammatory stimulus LPS in order to control the inflammatory response at feto-maternal interface.
authors.affiliation: Department of Life Sciences, University of Trieste, Trieste, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Masat
authors.affiliation: Institute for Maternal and Child Health, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) "Burlo Garofolo", Trieste, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Gasparini
authors.affiliation: Institute for Maternal and Child Health, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) "Burlo Garofolo", Trieste, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Agostinis
authors.affiliation: Department of Life Sciences, University of Trieste, Trieste, Italy.
authors.forename: Fleur
authors.initials: F
authors.lastname: Bossi
authors.affiliation: Institute for Maternal and Child Health, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) "Burlo Garofolo", Trieste, Italy.
authors.forename: Oriano
authors.initials: O
authors.lastname: Radillo
authors.affiliation: Department of Life Sciences, University of Trieste, Trieste, Italy.|Institute for Maternal and Child Health, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) "Burlo Garofolo", Trieste, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Seta
authors.affiliation: Section of General Pathology, Department of Medicine, School of Medicine, University of Verona, Verona, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Tamassia
authors.affiliation: Section of General Pathology, Department of Medicine, School of Medicine, University of Verona, Verona, Italy.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Cassatella
authors.affiliation: Department of Life Sciences, University of Trieste, Trieste, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Bulla
mesh_terms: D000022:Abortion, Spontaneous / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology; D004717:Endometrium / Q000276:immunology* / Q000473:pathology; D042783:Endothelial Cells / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D011247:Pregnancy; D051841:Transcription Factor RelB / Q000276:immunology*
chemical_list: D016207:Cytokines; C497593:RELB protein, human; D051841:Transcription Factor RelB