title: Characteristics of dynamic cerebral autoregulation in cerebral small vessel disease: Diffuse and sustained.
abstract: Cerebral small vessel disease is a major cause of stroke and vascular dementia; however, the pathogenesis is largely unclear. In this study, we investigated the characteristics of the impairment of dynamic cerebral autoregulation (dCA) in lacunar infarction patients. Seventy-one lacunar infarction patients were enrolled in the study, including 46 unilateral middle cerebral artery (MCA) territory stroke patients and 25 unilateral posterior cerebral artery (PCA) territory stroke patients. Each group of patients was randomly divided into two subgroups. Group 1 underwent dCA assessments in the bilateral MCAs, and Group 2 underwent dCA assessments in the bilateral PCAs. All patients were followed up for 6 months. Transfer function analysis was applied to derive the autoregulatory parameters of gain and phase difference. In the unilateral MCA territory stroke patients, impairments of dCA were observed in both the MCAs and PCAs, and the same results were observed in the unilateral PCA territory stroke patients. These impairments remained unchanged during the 6-month follow-up. In lacunar infarction, which is most prevalent type of cerebral small vessel disease, though patients with unilateral MCA territory/PCA territory stroke, the impairments of dCA were global and sustained. This finding suggests that the physiological changes associated with lacunar infarction were diffuse.
authors.affiliation: Neuroscience Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, China.
authors.forename: Zhen-Ni
authors.initials: ZN
authors.lastname: Guo
authors.affiliation: Center for Neurovascular ultrasound, the First Hospital of Jilin University, Chang Chun, China.
authors.forename: Yingqi
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Neuroscience Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Neuroscience Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, China.
authors.forename: Hongyin
authors.initials: H
authors.lastname: Ma
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Xueyuan Avenue, Shenzhen University Town, Shenzhen, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Neuroscience Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000503:physiopathology; D005724:Ganglia / Q000503:physiopathology; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis*; D020762:Infarction, Posterior Cerebral Artery / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000503:physiopathology; D013702:Temporal Lobe / Q000503:physiopathology; D013788:Thalamus / Q000503:physiopathology