title: Malaria vaccine based on self-assembling protein nanoparticles.
abstract: Despite recent progress with GSK's RTS,S malaria vaccine, there remains a desperate need for an efficient malaria vaccine. We have used a repetitive antigen display technology to display malaria specific B cell and T cell epitopes in an effort to design a vaccine against Plasmodium falciparum malaria. Our protein sequence when assembled into a nanoparticle induces strong, long-lived and protective immune responses against infection with the parasite. We are confident that the clinical trials with our most developed vaccine candidate will show good protection in a controlled human malaria infection trial.
authors.affiliation: a Institute of Materials, Science and Department of Molecular and Cell Biology , University of Connecticut , Storrs , CT 06269 , USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Burkhard
authors.affiliation: b Malaria Vaccine Branch , Walter Reed Army Institute of Research , Silver Spring , MD 20910 , USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Lanar
mesh_terms: D000913:Antibodies, Protozoan / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology; D004337:Drug Carriers / Q000494:pharmacology; D018985:Epitopes, B-Lymphocyte / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006801:Humans; D017780:Malaria Vaccines / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology / Q000517:prevention & control*; D053758:Nanoparticles / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000276:immunology*; D022223:Vaccines, Subunit / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D004337:Drug Carriers; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D017780:Malaria Vaccines; D022223:Vaccines, Subunit
keywords: Plasmodium falciparum; SAPN; malaria; nanoparticle; vaccine