title: Grade IV myositis: A rare complication of docetaxel.
abstract: An extremely rare case of acute inflammatory myopathy during combination chemotherapy with docetaxel and carboplatin for metastatic breast carcinoma in a 62-year-old diabetic female patient is reported. Despite the early clinical partial response of the underlying malignancy to the chemotherapeutic regimen, the patient developed symmetrical, painful, proximal muscle weakness in the lower limbs with peripheral edema after the administration of the third cycle of treatment. The syndrome regressed after the discontinuation of chemotherapy and the administration of corticosteroids.
authors.affiliation: Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Saini
authors.forename: D
authors.initials: D
authors.lastname: Chandragouda
authors.forename: Vineet
authors.initials: V
authors.lastname: Talwar
authors.forename: Sajjan
authors.initials: S
authors.lastname: Rajpurohit
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D000077143:Docetaxel; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009220:Myositis / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D005938:Glucocorticoids; D043823:Taxoids; D000077143:Docetaxel; D011239:Prednisolone