title: Myeloid cell-based therapies in neurological disorders: How far have we come?
abstract: The pathogenesis of neurological disorders such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) is multifactorial and incompletely understood. The development of therapies for these disorders of the central nervous system (CNS) is thus far very challenging. Neuroinflammation is one of the processes that contribute to the pathogenesis of CNS diseases, and therefore represents an important therapeutic target. Myeloid cells derived from the bone marrow are ideal candidates for cell therapy in the CNS as they are capable of targeting the brain and providing neuroprotective and anti-inflammatory effects. In this review, experimental and clinical evidence for the therapeutic potential of myeloid cells in neurological disorders will be discussed. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.
authors.affiliation: Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité - Universitätsmedizin Berlin, Germany. Electronic address: chotima.boettcher@charite.de.
authors.forename: Chotima
authors.initials: C
authors.lastname: Böttcher
authors.affiliation: Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité - Universitätsmedizin Berlin, Germany; Cluster of Excellence NeuroCure, DZNE and BIH, Berlin, Germany.
authors.forename: Josef
authors.initials: J
authors.lastname: Priller
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology / Q000628:therapy*; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology / Q000628:therapy*; D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D002493:Central Nervous System Diseases / Q000473:pathology; D006801:Humans; D009103:Multiple Sclerosis / Q000473:pathology / Q000628:therapy*; D022423:Myeloid Cells / Q000637:transplantation*
keywords: Alzheimer’s disease; Amyotrophic lateral sclerosis; Bone marrow; Multiple sclerosis; Neurodegeneration; Neuroinflammation; Stem cells