title: Effect of resistance ladder training on sparc expression in skeletal muscle of hindlimb immobilized rats.
abstract: Secreted protein acidic and rich in cysteine (SPARC) is associated with skeletal muscle atrophy. Here we examined possibility that resistance training could regulate SPARC expression in muscle atrophy in an immobilized hindlimb model.
  
  
  
  Sprague-Dawley rats underwent resistance ladder training and hindlimb immobilization. Cross sectional area and grip strength were measured. SPARC protein levels in the plantaris and soleus, and serum after exercise and immobilization were then analyzed.
  
  
  
  Resistance training decreased body weight (P < 0.001) and increased muscle quality (P < 0.001). In the plantaris, muscle atrophy (31.82%) and up-regulated SPARC expression (P < 0.05) after immobilization were alleviated by resistance training.
  
  
  
  Resistance training led to suppression of SPARC expression in the plantaris and showed a pretraining effect in atrophied rat muscle. Thus, SPARC may play a pivotal role in muscle homeostasis. Muscle Nerve 53: 951-957, 2016.
authors.affiliation: Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
authors.forename: Jun Seok
authors.initials: JS
authors.lastname: Son
authors.affiliation: Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
authors.forename: Jang Hoe
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
authors.forename: Hee-Jae
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Yoon
authors.affiliation: Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
authors.forename: Han Sol
authors.initials: HS
authors.lastname: Song
authors.affiliation: Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.|Institute on Aging, Seoul National University, Seoul, Korea.
authors.forename: Wook
authors.initials: W
authors.lastname: Song
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005786:Gene Expression Regulation / Q000502:physiology; D019417:Hindlimb Suspension / Q000009:adverse effects*; D008297:Male; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000209:etiology / Q000473:pathology* / Q000534:rehabilitation*; D015676:Osteonectin / Q000378:metabolism; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D055070:Resistance Training / Q000379:methods*
chemical_list: D015676:Osteonectin
keywords: compensatory effect; cross section area; muscle atrophy; muscle quality; pre-training effect