title: The rational design of a peptide-based hydrogel responsive to H2S.
abstract: The development of hydrogels that are responsive to external stimuli in a well-controlled manner is important for numerous biomedical applications. Herein we reported the first example of a hydrogel responsive to hydrogen sulphide (H2S). H2S is an important gasotransmitter whose deregulation has been associated with a number of pathological conditions. Our hydrogel design is based on the functionalization of an ultrashort hydrogelating peptide sequence with an azidobenzyl moiety, which was reported to react with H2S selectively under physiological conditions. The resulting peptide was able to produce hydrogels at a concentration as low as 0.1 wt%. It could then be fully degraded in the presence of excess H2S. We envision that the novel hydrogel developed in this study may provide useful tools for biomedical research.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. hongysun@cityu.edu.hk and Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, P. R. China.
authors.forename: Raoul
authors.initials: R
authors.lastname: Peltier
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. hongysun@cityu.edu.hk and Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, P. R. China.
authors.forename: Ganchao
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. hongysun@cityu.edu.hk and Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, P. R. China.
authors.forename: Haipeng
authors.initials: H
authors.lastname: Lei
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669.
authors.forename: Liqian
authors.initials: L
authors.lastname: Gao
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669.
authors.forename: Su Seong
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.
authors.forename: Zuankai
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. hongysun@cityu.edu.hk and Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, P. R. China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Sun
mesh_terms: D020100:Hydrogels / Q000737:chemistry*; D006862:Hydrogen Sulfide / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D010455:Peptides / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D010455:Peptides; D006862:Hydrogen Sulfide