title: Clinical profile and factors associated with mortality in hospitalized patients with HIV/AIDS: a retrospective analysis from Tripoli Medical Centre, Libya, 2013.
abstract: In Libya, little is known about HIV-related hospitalizations and in-hospital mortality. This was a retrospective analysis of HIV-related hospitalizations at Tripoli Medical Centre in 2013. Of 227 cases analysed, 82.4% were males who were significantly older (40.0 versus 36.5 years), reported injection drug use (58.3% versus 0%) and were hepatitis C virus co-infected (65.8% versus 0%) compared with females. Severe immunosuppression was prevalent (median CD4 count = 42 cell/μL). Candidiasis was the most common diagnosis (26.0%); Pneumocystis pneumonia was the most common respiratory disease (8.8%), while cerebral toxoplasmosis was diagnosed in 8.4% of patients. Current HAART use was independently associated with low risk of in-hospital mortality (OR 0.33), while central nervous system symptoms (OR 4.12), sepsis (OR 6.98) and low total lymphocyte counts (OR 3.60) were associated with increased risk. In this study, late presentation with severe immunosuppression was common, and was associated with significant in-hospital mortality.
authors.affiliation: Department of Infectious Diseases, Tripoli Medical Centre, Ain Zara, Tripoli, Libya; Department of Medicine, University of Tripoli, Ain Zara, Tripoli, Libya.
authors.forename: N S
authors.initials: NS
authors.lastname: Shalaka
authors.affiliation: Department of Infectious Diseases, Tripoli Medical Centre, Ain Zara, Tripoli, Libya.
authors.forename: N A
authors.initials: NA
authors.lastname: Garred
authors.affiliation: Department of Infectious Diseases, Tripoli Medical Centre, Ain Zara, Tripoli, Libya.
authors.forename: H T
authors.initials: HT
authors.lastname: Zeglam
authors.affiliation: Department of Infectious Diseases, Tripoli Medical Centre, Ain Zara, Tripoli, Libya.
authors.forename: S A
authors.initials: SA
authors.lastname: Awasi
authors.affiliation: Department of Infectious Diseases, Tripoli Medical Centre, Ain Zara, Tripoli, Libya.
authors.forename: L A
authors.initials: LA
authors.lastname: Abukathir
authors.affiliation: Department of Infectious Diseases, Tripoli Medical Centre, Ain Zara, Tripoli, Libya.
authors.forename: M E
authors.initials: ME
authors.lastname: Altagdi
authors.affiliation: Department of Infectious Diseases, Tripoli Medical Centre, Ain Zara, Tripoli, Libya; Department of Medicine, University of Tripoli, Ain Zara, Tripoli, Libya.
authors.forename: A A
authors.initials: AA
authors.lastname: Rayes
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000401:mortality; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000401:mortality; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D060085:Coinfection / Q000401:mortality; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000401:mortality*; D006526:Hepatitis C / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D008002:Libya / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000401:mortality