title: A viscoplastic model for the active component in cardiac muscle.
abstract: The HMK model (Hunter et al. in Prog Biophys Mol Biol 69:289-331, 1998) proposes mechanobiological equations for the influence of intracellular calcium concentration [Formula: see text] on the evolution of bound calcium concentration [Formula: see text] and the tropomyosin kinetics parameter z, which model processes in the active component of the tension in cardiac muscle. The inelastic response due to actin-myosin crossbridge kinetics is modeled in the HMK model with a function Q that depends on the history of the rate of total stretch of the muscle fiber. Here, an alternative model is proposed which models the active component of the muscle fiber as a viscoplastic material. In particular, an evolution equation is proposed for the elastic stretch [Formula: see text] in the active component. Specific forms of the constitutive equations are proposed and used to match experimental data. The proposed viscoplastic formulation allows for separate modeling of three processes: the high rate deactivation of crossbridges causing rapid reduction in active tension; the high but lower rate reactivation of crossbridges causing recovery of active tension; and the low rate relaxation effects characterizing the Hill model of muscles.
authors.affiliation: Faculty of Mechanical Engineering, Technion - Israel Institute of Technology, 32000, Haifa, Israel. mbrubin@tx.technion.ac.il.
authors.forename: M B
authors.initials: MB
authors.lastname: Rubin
mesh_terms: D001696:Biomechanical Phenomena; D002118:Calcium / Q000378:metabolism; D004548:Elasticity; D006706:Homeostasis; D042541:Intracellular Space / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism*; D014335:Tropomyosin / Q000378:metabolism; D014783:Viscosity
chemical_list: D014335:Tropomyosin; D002118:Calcium
keywords: Actin-myosin crossbridges; Active response; Cardiac muscle; Mechanobiology; Viscoplasticity