title: The Effects of Early Enteral Nutrition Products on the Healing of Colo-Colonic Anastomosis.
abstract: OBJECTIVE
  Complications after colorectal surgery have not been reduced in recent years. Anastomotic leakage is responsible for nearly all morbidity in colonic surgery and for about one third of the mortality.
  
  
  METHODS
  For the study, 34 albino Wistar rats (about 155-190 g in weight) were divided into four experimental groups. Each of the rats underwent an abdominal incision and resection of the colon 4 cm distal to the cecum to form a colo-colonic anastomosis. In the post-operative period, the first group (n=8) were fed with standard rat food and water, the second group (n=9) with dextrose+Ringer solution, the third group (n=9) with Biosorb® (Nutricia, Zoetermeer, The Netherlands), and the fourth group (n=8) with Impact® (Novartis Nutrition, USA).
  
  
  RESULTS
  The blow-out pressure of the anastomoses was significantly different in the group fed 5% dextrose+Ringer solution group than in the Biosorb® and Impact® groups.
  
  
  CONCLUSIONS
  None of the various nutrients investigated in the present study were significantly superior to standard foods in terms of the blow-out pressures. On the other hand, immunonutrients were more beneficial effects than other nutrients in terms of the healing of colonic anastomoses and post-operative weight loss.
authors.affiliation: Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sit
authors.affiliation: Department of General Surgery, Cayeli State Hospital, Rize, Turkey.
authors.forename: Ahmet S
authors.initials: AS
authors.lastname: Ilgun
authors.affiliation: Department of General Surgery, Ardahan State Hospital, Ardahan, Turkey.
authors.forename: Oguz
authors.initials: O
authors.lastname: Catal
authors.affiliation: Department of General Surgery, Taksim Training and Education Hospital, Istanbul, Turkey.
authors.forename: Ferda N
authors.initials: FN
authors.lastname: Koksoy
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: Gülali
authors.initials: G
authors.lastname: Aktas
authors.affiliation: Department of General Surgery, Istanbul University, Istanbul, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Cihan
mesh_terms: D000714:Anastomosis, Surgical; D057868:Anastomotic Leak / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D003106:Colon / Q000601:surgery*; D004750:Enteral Nutrition / Q000379:methods*; D005526:Food, Formulated; D009752:Nutritional Status; D017208:Rats, Wistar; D013997:Time Factors; D014945:Wound Healing