title: Revealing the ventral amygdalofugal pathway of the human limbic system using high spatial resolution diffusion tensor tractography.
abstract: The amygdala is known to have a role in core processes regulated by the limbic system such as motivation, memory, emotion, social behavior, self-awareness as well as certain primitive instincts. Several functional studies have investigated some of these brain tasks of the human limbic system. However, the underlying neuronal fiber connectivity of the amygdalo-diencephalon, as part of the limbic system, has not been delineated separately by prior diffusion-weighted imaging studies. The ability to trace the underlying fiber connections individually will be helpful in understanding the neurophysiology of these tracts in different functions. To date, few diffusion-weighted studies have focused on the amygdala, yet the fine connections of the amygdala, hypothalamus, septum or other adjacent limbic structures have yet to be elucidated by diffusion-weighted tractography studies. We therefore aimed to further investigate these fine neuronal connections using fiber tractography and high spatial resolution diffusion tensor imaging on 3T on 15 healthy right-handed male human subjects (age range 24-37 years). The ventral amygdalofugal pathway, anterior commissure and stria terminalis are the three main efferent pathways of the amygdala. We delineated the detailed trajectories of the ventral amygdalofugal tract, anterior commissure and their connections bilaterally in 15 normal adult human brains. Using a high-resolution diffusion tensor tractography technique, for the first time, we were able to demonstrate the trajectory of amygdalofugal tract and its connections to the hypothalamic and septal nuclei. We further revealed, for the first time, the close relationship of the amygdalofugal tract and anterior commissure with the fornix, stria terminalis and uncinate fasciculus bilaterally in 15 healthy adult human brains.
authors.affiliation: Division of Neuroradiology, Department of Diagnostic Radiology, Johns Hopkins University, 600 N. Wolfe St. Phipps B112B, Baltimore, MD, 21287, USA. akamali1@jhmi.edu.
authors.forename: Arash
authors.initials: A
authors.lastname: Kamali
authors.affiliation: Division of Neuroradiology, Department of Diagnostic Radiology, Johns Hopkins University, 600 N. Wolfe St. Phipps B112B, Baltimore, MD, 21287, USA.
authors.forename: Haris I
authors.initials: HI
authors.lastname: Sair
authors.affiliation: Division of Neuroradiology, Department of Diagnostic Radiology, Johns Hopkins University, 600 N. Wolfe St. Phipps B112B, Baltimore, MD, 21287, USA.
authors.forename: Ari M
authors.initials: AM
authors.lastname: Blitz
authors.affiliation: Departments of Diagnostic Radiology, University of Texas at Houston, Houston, TX, USA.
authors.forename: Roy F
authors.initials: RF
authors.lastname: Riascos
authors.affiliation: Division of Neuroradiology, Department of Diagnostic Radiology, Johns Hopkins University, 600 N. Wolfe St. Phipps B112B, Baltimore, MD, 21287, USA.
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Mirbagheri
authors.affiliation: UTHealth Department of Physical Medicine and Rehabilitation, TIRR NeuroRecovery Research Center, Houston, USA.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Keser
authors.affiliation: Departments of Diagnostic Radiology, University of Texas at Houston, Houston, TX, USA.
authors.forename: Khader M
authors.initials: KM
authors.lastname: Hasan
mesh_terms: D000328:Adult; D000679:Amygdala / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008032:Limbic System / Q000033:anatomy & histology*; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology; D066127:White Matter / Q000033:anatomy & histology*; D055815:Young Adult
keywords: Amygdala; Amygdalofugal; Anterior commissure; Diffusion tensor imaging; High resolution; Hippocampus; Hypothalamus; Limbic; Tractography