title: Three-Dimensional Printing of Hollow-Struts-Packed Bioceramic Scaffolds for Bone Regeneration.
abstract: Three-dimensional printing technologies have shown distinct advantages to create porous scaffolds with designed macropores for application in bone tissue engineering. However, until now, 3D-printed bioceramic scaffolds only possessing a single type of macropore have been reported. Generally, those scaffolds with a single type of macropore have relatively low porosity and pore surfaces, limited delivery of oxygen and nutrition to surviving cells, and new bone tissue formation in the center of the scaffolds. Therefore, in this work, we present a useful and facile method for preparing hollow-struts-packed (HSP) bioceramic scaffolds with designed macropores and multioriented hollow channels via a modified coaxial 3D printing strategy. The prepared HSP scaffolds combined high porosity and surface area with impressive mechanical strength. The unique hollow-struts structures of bioceramic scaffolds significantly improved cell attachment and proliferation and further promoted formation of new bone tissue in the center of the scaffolds, indicating that HSP ceramic scaffolds can be used for regeneration of large bone defects. In addition, the strategy can be used to prepare other HSP ceramic scaffolds, indicating a universal application for tissue engineering, mechanical engineering, catalysis, and environmental materials.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.|Department of Biomedical Engineering, Health Science Center, Shenzhen University , Shenzhen 518060, China.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Luo
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhai
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Huan
authors.affiliation: Xuhui District Central Hospital , 966 Middle Huaihai Road, Shanghai 200000, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, School of Medicine, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University , Shanghai 200011, China.
authors.forename: Lunguo
authors.initials: L
authors.lastname: Xia
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
authors.forename: Chengtie
authors.initials: C
authors.lastname: Wu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D001842:Bone and Bones / Q000473:pathology; D002384:Catalysis; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D002516:Ceramics / Q000737:chemistry*; D019245:Compressive Strength; D006801:Humans; D008855:Microscopy, Electron, Scanning; D044367:Phase Transition; D016062:Porosity; D066330:Printing, Three-Dimensional; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials
keywords: 3D printing; bioceramics; bone tissue engineering; hollow-struts scaffolds