title: The Association of Serum IL-33 and sST2 with Breast Cancer.
abstract: Breast cancer is one of the most common malignant diseases in women. The main cause of death from breast cancer is its metastases at distant sites in the body. Interleukin-33 (IL-33) is a cytokine of the IL-1 family and found overexpressed in various cancers. The aim of the present study was to explore the association of serum IL-33 and sST2 with breast cancer. Here, the serum levels of Interleukin-33 (IL-33) and sST2 were found significantly higher in breast cancer patients than in healthy volunteers. Serum levels of vascular endothelial growth factor (VEGF), metalloproteinase-11 (MMP-11), and platelet-derived growth factor-C (PDGF-C) were also greater in breast cancer patients compared to healthy volunteers. We found that serum levels of IL-33 or sST2 were positively correlated with the serum levels of VEGF, MMP-11, and PDGF-C. Moreover, breast cancer dataset downloaded from The Cancer Genome Atlas showed that patients with higher level of MMP-11 or PDGF-C expression had shorter survival time than those with lower level of these proteins. In conclusion, IL-33 and sST2 may serve as noninvasive diagnosis markers for breast cancer. IL-33 and sST2 were significantly associated with MMP-11 or PDGF-C which indicated poor prognosis of breast cancer patients.
authors.affiliation: Oncology Department, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Yang
authors.affiliation: Oncology Department, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
authors.forename: Dan-Yan
authors.initials: DY
authors.lastname: Ling
authors.affiliation: Oncology Department, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Xie
authors.affiliation: Oncology Department, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
authors.forename: Wan-Xin
authors.initials: WX
authors.lastname: Wu
authors.affiliation: Oncology Department, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
authors.forename: Jin-Rui
authors.initials: JR
authors.lastname: Li
authors.affiliation: Oncology Department, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Oncology Department, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
authors.forename: Jia-Lian
authors.initials: JL
authors.lastname: Zheng
authors.affiliation: Oncology Department, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
authors.forename: Yao-Hua
authors.initials: YH
authors.lastname: Fan
authors.affiliation: Oncology Department, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33 / Q000097:blood*; D008222:Lymphokines / Q000097:blood; D053507:Matrix Metalloproteinase 11 / Q000097:blood; D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D042461:Vascular Endothelial Growth Factor A; C411423:platelet-derived growth factor C; C511771:MMP11 protein, human; D053507:Matrix Metalloproteinase 11