title: Preeclampsia is associated with an increased pro-inflammatory profile in newborns.
abstract: Hypertensive disorders of pregnancy (HDP) lead to high rates of maternal and fetal morbidity. Existing studies on inflammatory marker TNFα in HDP offspring are inconsistent. We performed a population-based cohort study of 636 pregnancies, including normotensive (NT) women and women with preeclampsia (PE) or gestational hypertension (GH). TNFα was measured in maternal blood in the first and second trimesters and in cord blood at the time of delivery. Cord blood TNFα was higher in offspring delivered of women with PE (6.53 [4.94-8.38]pg/mL) versus those delivered of NT women (5.13 [4.11-6.72]pg/mL; p=0.01), independent of confounders. Maternal TNFα levels were not different among groups (p>0.1) in either the first or second trimester.
authors.affiliation: Département de médecine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Guillemette
authors.affiliation: Département de médecine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Lacroix
authors.affiliation: Département de mathématiques, Faculté des sciences, Université de Sherbrooke, 2500, boul. de l'Université, Sherbrooke J1K 2R1, QC, Canada.
authors.forename: Catherine
authors.initials: C
authors.lastname: Allard
authors.affiliation: Département de médecine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Patenaude
authors.affiliation: Département de médecine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Battista
authors.affiliation: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Myriam
authors.initials: M
authors.lastname: Doyon
authors.affiliation: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Moreau
authors.affiliation: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Ménard
authors.affiliation: Département de médecine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Ardilouze
authors.affiliation: Département de médecine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Patrice
authors.initials: P
authors.lastname: Perron
authors.affiliation: Département de médecine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Côté
authors.affiliation: Département de médecine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, 3001 12(e) Avenue Nord, Sherbrooke J1H 5N4, QC, Canada; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, 133 Brookline Avenue, Boston 02215, MA, USA; Diabetes Unit, Massachusetts General Hospital, 55 Fruit Street, Boston 02114, MA, USA. Electronic address: marie-france_hivert@harvardpilgrim.org.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Hivert
mesh_terms: D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology; D011247:Pregnancy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Gestational hypertension; Preeclampsia; TNFα; Umbilical cord