title: The inhibitory effects of γ-glutamylcysteine derivatives from fresh garlic on glycation radical formation.
abstract: The effects of three reactive peptides, γ-glutamylmethylcysteine (γ-GMC), γ-glutamylpropylcysteine (γ-GPC), and γ-glutamylbutylcysteine (γ-GBC) on the suppression of reactive radicals during the heating of l-lysine in the presence or absence of glucose was studied by electron spin resonance spectroscopy. γ-GMC and γ-GPC were extracted from fresh garlic, and γ-GBC was a synthetic peptide. The results showed that γ-GMC and γ-GPC effectively suppress formation of l-lysine radicals, but that γ-GBC exhibits low radical inhibition. The origin of the short peptides, and the length of their side chain, influenced their surface hydrophobicity and subsequent radical inhibition. In addition, the oxidation of l-lysine was inhibited by the peptides in a similar manner to their inhibition of the Maillard reaction (MR), and their radical inhibition was consistent with similar activity towards N(ε)-(carboxymethyl)lysine (CML).
authors.affiliation: The College of Food Science, Shenyang Agricultural University, Shenyang 110866, Liaoning, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Shi
authors.affiliation: The College of Food Science, Shenyang Agricultural University, Shenyang 110866, Liaoning, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Bai
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China.
authors.forename: Shufeng
authors.initials: S
authors.lastname: Ma
authors.affiliation: The College of Food Science, Shenyang Agricultural University, Shenyang 110866, Liaoning, China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Ji
authors.affiliation: The College of Food Science, Shenyang Agricultural University, Shenyang 110866, Liaoning, China. Electronic address: liuling4568@sina.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
mesh_terms: D004151:Dipeptides / Q000737:chemistry*; D005737:Garlic / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000737:chemistry*; D006031:Glycosylation; D015416:Maillard Reaction
chemical_list: D004151:Dipeptides; D017127:Glycation End Products, Advanced; C017341:gamma-glutamylcysteine
keywords: ESR; Fresh garlic; Glycation end-products; Intermediary radicals; Maillard reaction; Reactive peptides