title: The influence of comorbidities on mortality in sarcoidosis: a observational prospective cohort study.
abstract: OBJECTIVE
  The aim of this study was to identify the frequency and prevalence of comorbidities in sarcoid patients and to assess their influence on overall mortality in the cohort of patients with sarcoidosis.
  
  
  METHODS
  A cohort of 557 patients with histologically confirmed sarcoidosis diagnosed between 2007 and 2011 and a group of non-sarcoid controls were observed. All patients were carefully observed for comorbidities and mortality.
  
  
  RESULTS
  291 males (52.2%) and 266 females (47.8%) with mean age 48.4 ± 12.0 years in sarcoidosis group and a group of 100 controls with mean age (49.25 ± 10.3) were observed. The mean number of comorbidities in both groups was similar (0.9 ± 0.99 vs 0.81 ± 0.84 NS). The frequency of thyroid disease was significantly higher in sarcoidosis group comparing to controls at the time of diagnosis (OR = 3.62 P = 0.0144). During the observation period (median 58.0 months), 16 patients died (2.9%). The mean number of comorbidities was significantly higher in the groups of non-survivors as compared to survivors (2.8 ± 1.0, vs 0.8 ± 0.9), P < 0.0001.
  
  
  CONCLUSIONS
  The comorbidity burden has strong impact on mortality in sarcoidosis. Thyroid diseases are more frequent in sarcoidosis than in non-sarcoid controls.
authors.affiliation: 2nd Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Nowiński
authors.affiliation: 2nd Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Puścińska
authors.affiliation: 2nd Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Goljan
authors.affiliation: Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Peradzynska
authors.affiliation: 2nd Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Bednarek
authors.affiliation: 2nd Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Damian
authors.initials: D
authors.lastname: Korzybski
authors.affiliation: 2nd Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kamiński
authors.affiliation: 2nd Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Stokłosa
authors.affiliation: 2nd Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Czystowska
authors.affiliation: 4th Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Śliwiński
authors.affiliation: 2nd Department of Respiratory Medicine, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Górecka
mesh_terms: D000328:Adult; D015331:Cohort Studies; D015897:Comorbidity / Q000639:trends*; D017281:Cost of Illness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012507:Sarcoidosis / Q000145:classification / Q000453:epidemiology* / Q000401:mortality* / Q000473:pathology; D013147:Spirometry / Q000379:methods / Q000592:standards; D016019:Survival Analysis; D013959:Thyroid Diseases / Q000150:complications / Q000453:epidemiology / Q000401:mortality
keywords: comorbidities - mortality - sarcoidosis - survival