title: Effect of a family history of psoriasis and age on comorbidities and quality of life in patients with moderate to severe psoriasis: Results from the ARIZONA study.
abstract: Psoriasis is a chronic inflammatory skin disease whose clinical characteristics vary from patient to patient. We aimed to analyze how comorbidities and quality of life (QoL, as per the Dermatology Life Quality Index [DLQI]) may be affected by a family history of psoriasis and by age. The ARIZONA study was a multicenter, cross-sectional study in 1022 adult patients diagnosed with moderate to severe psoriasis at least 6 months prior to inclusion. The severity of psoriasis and the proportion of patients with comorbidities were not affected by the presence of a family history. The regression analysis revealed that the presence of a family history of psoriasis was associated with the effect on the patient's QoL (P = 0.002), regardless of disease severity. The mean DLQI total score varied significantly across age groups (5.1 ± 5.3 for the 18-30-year group, 5.7 ± 6.5 for the 31-60-year group and 3.8 ± 5.1 for the >60-year group; P = 0.001). In conclusion, the presence of a family history of psoriasis appears to disrupt QoL in patients with moderate to severe psoriasis, but it hardly affected the prevalence of comorbid conditions. The effect of age on QoL was particularly noticeable in younger patients, highlighting its negative impact. As expected, older patients appeared to be burdened with a higher number of comorbidities than their younger counterparts.
authors.affiliation: Hospital Universitario Fundación Alcorcón, Madrid, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: López-Estebaranz
authors.affiliation: Hospital General Universitario de Valencia, Valencia, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Sánchez-Carazo
authors.affiliation: Medical Affairs Department, Janssen, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Sulleiro
mesh_terms: D000328:Adult; D000367:Age Factors; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology* / Q000235:genetics*; D011788:Quality of Life; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: age; comorbidities; family history; psoriasis; quality of life