title: Teeth loss, teeth brushing and esophageal carcinoma: a systematic review and meta-analysis.
abstract: Esophageal carcinoma (EC) is a serious malignancy, and its epidemiologic etiology is not fully explained. We performed this review to investigate the association between teeth loss and teeth brushing and the risk of EC. A systematic search was conducted to identify all relevant studies. The Q test and I(2) statistic were used to examine between-study heterogeneity. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were considered by fixed or random effects models. Furthermore, we conducted subgroup analyses based on study design, the studies' geographic regions and case type of origin. Modified Egger linear regression test was used to estimate publication bias. Ten articles were included. Pooled analyses indicated that teeth loss was associated with an increased risk of EC for Asians (OR, 1.52; 95% CI: 1.30, 1.78), and high frequency of teeth brushing was associated with a lower incidence of EC (OR, 0.62; 95%CI: 0.43, 0.89). Subgroup analyses showed consistent results and no publication bias existed. Teeth loss and teeth brushing play potential roles in the progressing of EC. People should take care of their oral health in daily life. And large well-designed researches are needed to fully describe the association between teeth health and EC risk.
authors.affiliation: Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, China.|Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, China.|Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Nie
authors.affiliation: Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, China.|Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, China.|Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015984:Causality; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods; D017678:Sex Distribution; D016388:Tooth Loss / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D014099:Toothbrushing / Q000706:statistics & numerical data*; D055815:Young Adult