title: Acute and Subacute Oral Toxicity Evaluation of Crude Antifungal Compounds Produced by Lactobacillus plantarum HD1 in Rats.
abstract: The aim of this study was to investigate the acute and subacute oral toxicity of crude antifungal compounds produced by Lactobacillus plantarum HD1 in Sprague-Dawley rats. In the acute toxicity study, the crude antifungal compounds (0.625, 1.25, 2.5, and 5.0 g/kg) did not produce mortality, significant changes in general behavior, or changes in the gross appearance of the organs. In the subacute toxicity study, the crude antifungal compounds were administered orally to rats at doses of 0, 0.5, 1.0, and 2.0 g/kg daily for 28 days. There were no test article-related deaths, abnormal clinical signs, or body weight changes. The study also showed no significant differences between the control and treated groups in hematological and serum biochemical parameters, histopathological examination, or any other findings. These results suggest that acute or subacute oral administration of crude antifungal compounds from L. plantarum HD1 is not toxic in rats.
authors.affiliation: Department of Food and Nutrition, Chosun University, Gwangju 61452, Korea.
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Son
authors.affiliation: Department of Food and Nutrition, Chosun University, Gwangju 61452, Korea.
authors.forename: Hae-Choon
authors.initials: HC
authors.lastname: Chang
authors.affiliation: Department of Food and Nutrition, Chosun University, Gwangju 61452, Korea.
authors.forename: Jae-Joon
authors.initials: JJ
authors.lastname: Lee
keywords: Lactobacillus plantarum HD1; acute toxicity; crude antifungal compounds; subacute toxicity