title: Accuracy of percentage of signal intensity recovery and relative cerebral blood volume derived from dynamic susceptibility-weighted, contrast-enhanced MRI in the preoperative diagnosis of cerebral tumours.
abstract: Conventional magnetic resonance imaging (MRI) is the technique of choice for diagnosis of cerebral tumours, and has become an increasingly powerful tool for their evaluation; however, the diagnosis of common contrast-enhancing lesions can be challenging, as it is sometimes impossible to differentiate them using conventional imaging. Histopathological analysis of biopsy specimens is the gold standard for diagnosis; however, there are significant risks associated with the invasive procedure and definitive diagnosis is not always achieved. Early accurate diagnosis is important, as management differs accordingly. Advanced MRI techniques have increasing utility for aiding diagnosis in a variety of clinical scenarios. Dynamic susceptibility-weighted contrast-enhanced (DSC) MRI is a perfusion imaging technique and a potentially important tool for the characterisation of cerebral tumours. The percentage of signal intensity recovery (PSR) and relative cerebral blood volume (rCBV) derived from DSC MRI provide information about tumour capillary permeability and neoangiogenesis, which can be used to characterise tumour type and grade, and distinguish tumour recurrence from treatment-related effects. Therefore, PSR and rCBV potentially represent a non-invasive means of diagnosis; however, the clinical utility of these parameters has yet to be established. We present a review of the literature to date.
authors.affiliation: St Vincent's Clinical School, University of New South Wales, Sydney, Australia ananya.chakravorty@gmail.com.
authors.forename: Ananya
authors.initials: A
authors.lastname: Chakravorty
authors.affiliation: Department of Neurosurgery, St Vincent's Hospital, Sydney, Australia.
authors.forename: Timothy
authors.initials: T
authors.lastname: Steel
authors.affiliation: Department of Radiology, St Vincent's Hospital, Sydney, Australia.
authors.forename: Joga
authors.initials: J
authors.lastname: Chaganti
mesh_terms: D001810:Blood Volume; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019635:Neurosurgical Procedures / Q000379:methods; D015203:Reproducibility of Results
keywords: Blood-brain barrier; brain tumour; cerebral blood volume; diagnostics; dynamic susceptibility; glioblastoma; magnetic resonance imaging; neoangiogenesis; perfusion imaging; review; signal intensity recovery; tumour capillary permeability; tumour typing