title: Linker histone H1 and protein-protein interactions.
abstract: Linker histones H1 are ubiquitous chromatin proteins that play important roles in chromatin compaction, transcription regulation, nucleosome spacing and chromosome spacing. H1 function in DNA and chromatin structure stabilization is well studied and established. The current paradigm of linker histone mode of function considers all other cellular roles of linker histones to be a consequence from H1 chromatin compaction and repression. Here we review the multiple processes regulated by linker histones and the emerging importance of protein interactions in H1 functioning. We propose a new paradigm which explains the multi functionality of linker histones through linker histones protein interactions as a way to directly regulate recruitment of proteins to chromatin.
authors.affiliation: Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA.
authors.forename: Anna A
authors.initials: AA
authors.lastname: Kalashnikova
authors.affiliation: Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Rogge
authors.affiliation: Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA. Electronic address: Jeffrey.C.Hansen@colostate.edu.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Hansen
mesh_terms: D000682:Amyloid / Q000502:physiology; D000818:Animals; D006657:Histones / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: D000682:Amyloid; D006657:Histones
keywords: Chromatin; Genome; Intrinsic disorder; Nucleolus; Nucleosome; Transcription; mRNA splicing