title: Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses.
abstract: OBJECTIVE
  Pancreatic juice cytology (PJC) is considered optimal for differentially diagnosing pancreatic masses, but the accuracy of PJC ranges from 46.7% to 93.0%. The aim of this study was to evaluate the clinical impact of measuring the KL-6 concentration of pancreatic juice for diagnosing pancreatic masses.
  
  
  METHODS
  PJC and the KL-6 concentration measurements of pancreatic juice were performed for 70 consecutive patients with pancreatic masses (39 malignancies and 31 benign).
  
  
  RESULTS
  The average KL-6 concentration of pancreatic juice was significantly higher for pancreatic ductal adenocarcinomas (PDACs) (167.7 ± 396.1 U/mL) and intraductal papillary mucinous carcinomas (IPMCs) (86.9 ± 21.1 U/mL) than for pancreatic inflammatory lesions (17.5 ± 15.7 U/mL, P = 0.034) and intraductal papillary mucinous neoplasms (14.4 ± 2.0 U/mL, P = 0.026), respectively. When the cut-off level of the KL-6 concentration of pancreatic juice was 16 U/mL, the sensitivity, specificity, and accuracy of the KL-6 concentration of pancreatic juice alone were 79.5%, 64.5%, and 72.9%, respectively. Adding the KL-6 concentration of pancreatic juice to PJC when making a diagnosis caused the values of sensitivity and accuracy of PJC to increase by 15.3% (P = 0.025) and 8.5% (P = 0.048), respectively.
  
  
  CONCLUSIONS
  The KL-6 concentration of pancreatic juice may be as useful as PJC for diagnosing PDACs.
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, 36-1 Nishi-cho, Yonago 683-8504, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, 36-1 Nishi-cho, Yonago 683-8504, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, 36-1 Nishi-cho, Yonago 683-8504, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, 36-1 Nishi-cho, Yonago 683-8504, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Onoyama
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, 36-1 Nishi-cho, Yonago 683-8504, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kawata
authors.affiliation: Department of Pathology, Tottori University Hospital, Yonago 683-8504, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Horie
authors.affiliation: Department of Surgery, Tottori University Hospital, Yonago 683-8504, Japan.
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Sakamoto
authors.affiliation: Center for Promoting Next-Generation Highly Advanced Medicine, Tottori University Hospital, Yonago 683-8504, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Ueki
authors.affiliation: Department of Pharmacotherapeutics, Tottori University Hospital, Yonago 683-8504, Japan.
authors.forename: Norimasa
authors.initials: N
authors.lastname: Miura
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, 36-1 Nishi-cho, Yonago 683-8504, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Murawaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis*; D010189:Pancreatic Juice / Q000737:chemistry*; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; C060192:MUC1 protein, human; D018396:Mucin-1