title: Dynamic Changes in DNA Damage and Repair Biomarkers with Employment Length among Nickel Smelting Workers.
abstract: Our study explored the dynamic changes in and the relationship between the DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) and the DNA repair marker 8-hydroxyguanine DNA glycosidase 1 (hOGG1) according to the length of occupational employment in nickel smelting workers. One hundred forty nickel-exposed smelting workers and 140 age-matched unexposed office workers were selected from the Jinchang cohort. The 8-OHdG levels in smelting workers was significantly higher than in office workers (Z=-8.688, P<0.05) and the 8-OHdG levels among nickel smelting workers in the 10-14 y employment length category was significantly higher than among all peers. The hOGG1 levels among smelting workers were significantly lower than those of non-exposed workers (Z=-8.948, P<0.05). There were significant differences between employment length and hOGG1 levels, with subjects employed in nickel smelting for 10-14 y showing the highest levels of hOGG1. Correlation analysis showed positive correlations between 8-OHdG and hOGG1 levels (r=0.413; P<0.01). DNA damage was increased with employment length among nickel smelting workers and was related to the inhibition of hOGG1 repair capacity.
authors.affiliation: Institute of Epidemiology and Statistics; Center for Cancer Prevention and Treatment, School of Public Health, Lanzhou University, Lanzhou 730000, Gansu, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Wu
authors.affiliation: Institute of Epidemiology and Statistics; Center for Cancer Prevention and Treatment, School of Public Health, Lanzhou University, Lanzhou 730000, Gansu, China.
authors.forename: Ya Na
authors.initials: YN
authors.lastname: Bai
authors.affiliation: Workers' Hospital of Jinchuan Company, Jinchuan Group Co. Ltd., Jinchang 737103, Gansu, China.
authors.forename: Hong Quan
authors.initials: HQ
authors.lastname: Pu
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Jie
authors.initials: J
authors.lastname: He
authors.affiliation: School of Public Health, Brown University, Providence, RI, USA.
authors.forename: Tong Zhang
authors.initials: TZ
authors.lastname: Zheng
authors.affiliation: Workers' Hospital of Jinchuan Company, Jinchuan Group Co. Ltd., Jinchang 737103, Gansu, China.
authors.forename: Hai Yan
authors.initials: HY
authors.lastname: Li
authors.affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.affiliation: College of Basic Medicine, Lanzhou University, Lanzhou 730000, Gansu, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Cheng
mesh_terms: D015415:Biomarkers; D016022:Case-Control Studies; D015331:Cohort Studies; D004249:DNA Damage / Q000187:drug effects*; D045647:DNA Glycosylases / Q000097:blood; D004260:DNA Repair; D003839:Deoxyadenosines / Q000097:blood; D006801:Humans; D008297:Male; D008669:Metallurgy; D009532:Nickel / Q000633:toxicity* / Q000652:urine; D016273:Occupational Exposure / Q000009:adverse effects*; D013997:Time Factors
chemical_list: C436623:8-hydroxy-2'-deoxyadenosine; D015415:Biomarkers; D003839:Deoxyadenosines; D009532:Nickel; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human