title: Correlation between aortic stiffness and left atrial volume index in hypertensive patients.
abstract: BACKGROUND
  Both arterial stiffness and left atrial volume index are crucial predictors of cardiovascular outcomes in hypertensive patients. The correlation between these two factors has not been previously well established in hypertensive population.
  
  
  OBJECTIVE
  To determine the correlation between arterial stiffness and left atrial volume index in hypertensive patients.
  
  
  RESULTS
  The study was performed in 111 consecutive hypertensive patients (49.5% male, mean age 70.8 ± 10.3 years) undergoing cardiac magnetic resonance imaging (CMR). Arterial stiffness was determined by pulse wave velocity in the thoracic aorta by velocity-encoded imaging. Left atrial volume was assessed by biplane area-length method. Pulse wave velocity was significantly correlated with left atrial volume index in univariate analysis (r = 0.20, p = 0.032). In multivariate analysis, pulse wave velocity, coronary artery disease and left ventricular mass remain independent predictors (β = 1.01, p = 0.02).
  
  
  CONCLUSIONS
  Increased arterial stiffness correlates with left atrial enlargement in hypertensive patients. The prevention of left atrial enlargement and subsequent complications by specific antihypertensive drugs with positive effect on aortic stiffness warrants further studies.
authors.affiliation: a Division of Cardiology , Department of Medicine, Siriraj Hospital, Mahidol University , Bangkok , Thailand.
authors.forename: Satit
authors.initials: S
authors.lastname: Janwanishstaporn
authors.affiliation: a Division of Cardiology , Department of Medicine, Siriraj Hospital, Mahidol University , Bangkok , Thailand.
authors.forename: Thananya
authors.initials: T
authors.lastname: Boonyasirinant
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001013:Aorta, Thoracic / Q000503:physiopathology*; D006332:Cardiomegaly / Q000453:epidemiology / Q000473:pathology*; D003324:Coronary Artery Disease / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006325:Heart Atria / Q000473:pathology*; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009929:Organ Size; D063177:Pulse Wave Analysis; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology; D059289:Vascular Stiffness
chemical_list: D000959:Antihypertensive Agents
keywords: Aortic stiffness; diastolic function; hypertension; left atrial volume; magnetic resonance imaging; pulse wave velocity