title: Expression of protein TARBP1 in human hepatocellular carcinoma and its prognostic significance.
abstract: OBJECTIVE
  The objective of this study was to analyze the expression of TARBP1 and its clinical significance in hepatocellular carcinoma (HCC).
  
  
  METHODS
  90 patients with primary hepatocellular carcinoma were included in this study. The tumor and paired adjacent non-tumor tissues were collected. TARBP1 expression was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry. Associations of TARBP1 expression with the clinicopathological features were analyzed, and prognosis of HCC patients was evaluated.
  
  
  RESULTS
  The result show the expression of TARBP1 mRNA in liver cancer tissues were higher than in the adjacent normal liver tissues in 10 paired samples (P=0.0015). Compared with adjacent normal liver tissues, overexpression of TARBP1 was detected in 61.1% (55/90) HCC patients. TARBP1 expression was associated with the AJCC tumor stage (P=0.004) and clinical stage (P=0.005), and decreased overall survival (P=0.002). In multivariate analysis, TARBP1 expression was an independent prognostic factor for overall survival (Hazard ratio [HR]=2.773, 95% confidence interval [CI] 1.542-4.985; P=0.019).
  
  
  CONCLUSIONS
  TARBP1 is up-regulated in HCC, and the expression of TARBP1 was associated with the pathological grading and clinical stage. TARBP1 maybe is an independent prognostic marker of HCC patients.
authors.affiliation: Department of Blood Transfusion, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510230, China.
authors.forename: Jingmei
authors.initials: J
authors.lastname: Ye
authors.affiliation: Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510630, China.
authors.forename: Jiani
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510230, China.
authors.forename: Li
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Hematology, The First People's Hospital of Foshan Foshan 528000, China.
authors.forename: Shaojiang
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510230, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510230, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wu
authors.affiliation: PET/CT Center, Department of Nuclear Medicine, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510230, China.
authors.forename: Huaifu
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510230, China.
authors.forename: Huo
authors.initials: H
authors.lastname: Tan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation; D000099253:Trans-Activation Responsive RNA-Binding Protein
chemical_list: D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; C071598:TARBP1 protein, human; D000099253:Trans-Activation Responsive RNA-Binding Protein
keywords: Hepatocellular carcinoma-TARBP1- prognosis