title: Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols.
abstract: The lipid peroxidation of unsaturated fatty acids (UFAs) in the retina not only threatens visual cells but also affects the physiological health of the retina. In this work, the potential damages caused by daily visible light exposure on retinal UFAs were evaluated via a simulated in vitro model. At the same time, the benefits of dietary supplementation of blueberries to the eyes were also assessed. After prolonged light exposure, lipid peroxidation occurred for both docosahexaenoic and arachidonic acids (DHA and AA, respectively). The oxidized UFAs presented obvious cytotoxicity and significantly inhibited cell growth in retinal pigment epithelium cells. Among the different blueberry polyphenol fractions, the flavonoid-rich fraction, in which quercetin was discovered as the main component, was considerably better in preventing visible light-induced DHA lipid peroxidation than the anthocyanin- and phenolic acid-rich fractions. Then the retinal protective activity of blueberry polyphenols against light-induced retinal injury was confirmed in vivo. On the basis of the above results, inhibiting lipid peroxidation of UFAs in the retina is proposed to be another important function mechanism for antioxidants to nourish eyes.
authors.affiliation: College of Food and Biological Engineering, Jimei University , Xiamen, Fujian, People's Republic of China.
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Food and Biological Engineering, Jiangsu University , Zhenjiang, Jiangsu, People's Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.affiliation: College of Food Science & Nutritional Engineering, China Agricultural University , Beijing, People's Republic of China.
authors.forename: Jimei
authors.initials: J
authors.lastname: Hu
authors.affiliation: College of Food and Biological Engineering, Jimei University , Xiamen, Fujian, People's Republic of China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Liu
authors.affiliation: College of Food and Biological Engineering, Jimei University , Xiamen, Fujian, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Food and Biological Engineering, Jimei University , Xiamen, Fujian, People's Republic of China.
authors.forename: Lechang
authors.initials: L
authors.lastname: Sun
authors.affiliation: College of Food and Biological Engineering, Jimei University , Xiamen, Fujian, People's Republic of China.
authors.forename: Zedong
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: College of Food and Biological Engineering, Jimei University , Xiamen, Fujian, People's Republic of China.
authors.forename: Xichun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Food and Biological Engineering, Jimei University , Xiamen, Fujian, People's Republic of China.
authors.forename: Qingchou
authors.initials: Q
authors.lastname: Chen
authors.affiliation: College of Food Science & Nutritional Engineering, China Agricultural University , Beijing, People's Republic of China.
authors.forename: Baoping
authors.initials: B
authors.lastname: Ji
mesh_terms: D000818:Animals; D029798:Blueberry Plants / Q000737:chemistry*; D019587:Dietary Supplements / Q000032:analysis; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006801:Humans; D008027:Light / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D010936:Plant Extracts / Q000008:administration & dosage*; D059808:Polyphenols / Q000008:administration & dosage*; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D012164:Retinal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism
chemical_list: D005231:Fatty Acids, Unsaturated; D010936:Plant Extracts; D059808:Polyphenols
keywords: blueberries; lipid peroxidation; polyphenols; retina; unsaturated fatty acids