title: Office-based Autologous Fat Injection Laryngoplasty for Vocal Process Granuloma.
abstract: OBJECTIVE
  To present the outcomes of office-based autologous fat injection laryngoplasty for the treatment of vocal process granuloma in conjunction with glottic insufficiency.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  This study included nine patients with vocal process granuloma in conjunction with glottic insufficiency who received autologous fat injection laryngoplasty. Videolaryngostroboscopic data, objective voice assessment, perceptual measurements of vocal quality, and subjective ratings of voice quality were examined before and after treatment.
  
  
  RESULTS
  Of the nine patients, seven (78%) exhibited complete remission. The other two patients (22%) exhibited a partial response following the injection. In a subgroup of five patients who were refractory to antireflux and voice therapies, the resolution rate was 60%. Phonatory function presented significant improvements in jitter, noise-to-harmonic ratio, maximal phonation time, and asthenia. Videolaryngostroboscopic rating revealed significant improvements in closure phase ratio in the vibratory cycle.
  
  
  CONCLUSIONS
  Autologous fat injection laryngoplasty can ameliorate glottic insufficiency and the resulting hyperfunctional behavior of the larynx. This therapy also encourages remission of vocal process granuloma and may represent an alternative treatment strategy.
authors.affiliation: Voice Clinic, Department of Otolaryngology, Cheng Hsin General Hospital, Taipei, Taiwan.
authors.forename: Hao-Chun
authors.initials: HC
authors.lastname: Hu
authors.affiliation: Voice Clinic, Department of Otolaryngology, Cheng Hsin General Hospital, Taipei, Taiwan.
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Hung
authors.affiliation: Voice Clinic, Department of Otolaryngology, Cheng Hsin General Hospital, Taipei, Taiwan.
authors.forename: Shu-Yi
authors.initials: SY
authors.lastname: Lin
authors.affiliation: Voice Clinic, Department of Otolaryngology, Cheng Hsin General Hospital, Taipei, Taiwan; Department of Otolaryngology, National Yang-Ming University, Taipei, Taiwan.. Electronic address: hydiung@gmail.com.
authors.forename: Shyue-Yih
authors.initials: SY
authors.lastname: Chang
mesh_terms: D000162:Acoustics; D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D000368:Aged; D000556:Ambulatory Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D001284:Atrophy; D005260:Female; D006102:Granuloma, Laryngeal / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007267:Injections; D058753:Laryngoplasty / Q000009:adverse effects / Q000379:methods*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D010699:Phonation; D020127:Recovery of Function; D012189:Retrospective Studies; D013068:Speech Production Measurement; D049489:Stroboscopy; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014741:Video Recording; D014827:Vocal Cords / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D014832:Voice Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D014833:Voice Quality
keywords: Autologous fat; Glottic insufficiency; Injection laryngoplasty; Office-based surgery; Vocal process granuloma