title: [Analysis of factors associated with decline of FEV1 among community population in urban area of Beijing].
abstract: OBJECTIVE
  To investigate risk factors correlated to the decline of FEV₁among community population in the urban area of Beijing.
  
  
  METHODS
  Subjects no younger than 40 years old were recruited from three communities in the urban area of Beijing. All of them were asked to fill in a questionnaire in regard to general health conditions, past medical history, medication usage, smoking history, etc. FEV₁and FEV6 were measured by Vitalograph COPD-6 spirometer using the standard protocol. Two years after the first visit, questionnaire survey and spirometry were repeated.
  
  
  RESULTS
  Four hundred and fifty two subjects fulfilled the inclusion criteria and finished the 2nd visit, with an average age of (58.8 ± 8.6) years, 29% male and 71% female. The mean decline rate of FEV₁in the cohort was (43 ± 114) ml per year. There was no significant difference of mean FEV₁decline between different gender and age groups. A mean decline of FEV₁by (64 ± 125) ml per year was observed in smokers (including former smokers and current smokers) whereas the decline rate in non-smokers was (36 ± 109) ml per year (P = 0.030). There was no significant statistical difference among current smokers, former smokers, passive smokers and subjects who never smoke. A higher decline rate of FEV₁was observed in subjects with a history of COPD or airway hyperreactivity, chronic cough, diabetes, hypertension and coronary heart disease. The difference, however, was not statistically significant. Binary logistic regression was used to screen risk factors affected the FEV₁decline rate between rapid decline (ΔFEV1 ≥ 30 ml/y) and non-rapid decline (ΔFEV1 < 30 ml/y), and found smoking was an independent risk factor of FEV₁decline rate.
  
  
  CONCLUSIONS
  The mean rate of FEV1 decline in 2.6 years in the surveyed community population in the urban area of Beijing was (43 ± 114) ml per year; Smoking is an independent risk factor of FEV₁decline.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China.
authors.forename: Cuiyan
authors.initials: C
authors.lastname: Guo
authors.forename: Yanni
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Junqing
authors.initials: J
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Kang
authors.forename: Guoguang
authors.initials: G
authors.lastname: Xia
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Pingji
authors.initials: P
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: Email: wangguangfa@hotmail.com.
authors.forename: Guangfa
authors.initials: G
authors.lastname: Wang
mesh_terms: D001249:Asthma; D002908:Chronic Disease; D003371:Cough; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D016015:Logistic Models; D008171:Lung Diseases / Q000453:epidemiology*; D008297:Male; D012307:Risk Factors; D012907:Smoking; D013147:Spirometry; D011795:Surveys and Questionnaires; D014505:Urban Population