title: Managing variation in the investigation of organismal development: problems and opportunities.
abstract: This paper aims to clarify the consequences of new scientific and philosophical approaches for the practical-theoretical framework of modern developmental biology. I highlight normal development, and the instructive-permissive distinction, as key parts of this framework which shape how variation is conceptualised and managed. Furthermore, I establish the different dimensions of biological variation: the units, temporality and mode of variation. Using the analytical frame established by this, I interpret a selection of examples as challenges to the instructive-permissive distinction. These examples include the phenomena of developmental plasticity and transdifferentiation, the role of the microbiome in development, and new methodological approaches to standardisation and the assessment of causes. Furthermore, I argue that investigations into organismal development should investigate the effects of a wider range of kinds of variation including variation in the units, modes and temporalities of development. I close by examining various possible opportunities for producing and using normal development free of the assumptions of the instructive-permissive distinction. These opportunities are afforded by recent developments, which include new ways of producing standards incorporating more natural variation and being based on function rather than structure, and the ability to produce, store, and process large quantities of data.
authors.affiliation: Department of Sociology, Philosophy and Anthropology, and Egenis, The Centre for the Study of Life Sciences, University of Exeter, Byrne House, St. German's Road, Exeter, Devon, EX4 4PJ, UK. jwel201@ex.ac.uk.
authors.forename: James W E
authors.initials: JW
authors.lastname: Lowe
mesh_terms: D054338:Cell Transdifferentiation; D015509:Developmental Biology / Q000379:methods*; D064307:Microbiota; D008954:Models, Biological; D010684:Philosophy
keywords: Developmental biology; Instructive-permissive distinction; Normal development; Standards; Variation