title: Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours.
abstract: Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT.
authors.affiliation: Laboratório de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: T H M
authors.initials: TH
authors.lastname: Vargas
authors.affiliation: Laboratório de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, São Paulo, Brazil; Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: L H
authors.initials: LH
authors.lastname: Pulz
authors.affiliation: Laboratório de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, São Paulo, Brazil; Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: C N
authors.initials: CN
authors.lastname: Barra
authors.affiliation: Universidade Metodista de São Paulo, São Bernardo do Campo, São Paulo, Brazil.
authors.forename: S R
authors.initials: SR
authors.lastname: Kleeb
authors.affiliation: Universidade Metodista de São Paulo, São Bernardo do Campo, São Paulo, Brazil; Universidade Paulista, São Paulo, Brazil.
authors.forename: J G
authors.initials: JG
authors.lastname: Xavier
authors.affiliation: Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: J L
authors.initials: JL
authors.lastname: Catão-Dias
authors.affiliation: Laboratório de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: H
authors.initials: H
authors.lastname: Fukumasu
authors.affiliation: Universidade Anhembi-Morumbi, São Paulo, Brazil.
authors.forename: A T
authors.initials: AT
authors.lastname: Nishiya
authors.affiliation: Laboratório de Oncologia Comparada e Translacional, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, São Paulo, Brazil. Electronic address: rstrefezzi@usp.br.
authors.forename: R F
authors.initials: RF
authors.lastname: Strefezzi
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D007150:Immunohistochemistry; D034701:Mastocytosis, Cutaneous / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D050814:Octamer Transcription Factor-3 / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D050814:Octamer Transcription Factor-3
keywords: OCT4 protein; cancer stem cell; dog; mast cell tumour