title: Tuberculosis: pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice (Small 38/2015).
abstract: On page 5066, J. I. Zink, M. A. Horwitz, and co-workers use confocal microscopy to demonstrate the avid uptake of RITC-labeled mesoporous silica nanoparticles loaded with the anti-tuberculosis drug isoniazid (shown here in red) by human macrophages (nuclei stained blue with DAPI) infected with GFP-expressing Mycobacterium tuberculosis (shown here in green).
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, 3013 Young Dr. East, CA, 90095-1569, USA.
authors.forename: Angela A
authors.initials: AA
authors.lastname: Hwang
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CHS 37-121, 10833 Le Conte Ave., CA, 90095-1688, USA.
authors.forename: Bai-Yu
authors.initials: BY
authors.lastname: Lee
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CHS 37-121, 10833 Le Conte Ave., CA, 90095-1688, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Clemens
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CHS 37-121, 10833 Le Conte Ave., CA, 90095-1688, USA.
authors.forename: Barbara Jane
authors.initials: BJ
authors.lastname: Dillon
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, 3013 Young Dr. East, CA, 90095-1569, USA.|California NanoSystems Institute, University of California, Los Angeles, CA, 90095-8352, USA.
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CHS 37-121, 10833 Le Conte Ave., CA, 90095-1688, USA.
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Horwitz
mesh_terms: D000818:Animals; D006863:Hydrogen-Ion Concentration; D007538:Isoniazid / Q000627:therapeutic use*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D007538:Isoniazid
keywords: drug delivery; mesoporous silica; mesoporous silica nanoparticles; multifunctional nanoparticles; tuberculosis