title: The Life Cycle of the Nephron Progenitor.
abstract: Although we know that mesenchymal progenitors give rise to nephrons in the kidney, how they balance self-renewal versus differentiation is still unclear. In this issue of Developmental Cell, Chen et al. (2015) show that nephron progenitors age, but not necessarily irreversibly: old progenitors can be "rejuvenated" by a young crowd.
authors.affiliation: Murdoch Childrens Research Institute, Royal Children's Hospital and Department of Pediatrics, University of Melbourne, Melbourne VIC, Australia. Electronic address: melissa.little@mcri.edu.au.
authors.forename: Melissa H
authors.initials: MH
authors.lastname: Little
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D016922:Cellular Senescence; D007668:Kidney / Q000166:cytology*; D009399:Nephrons / Q000166:cytology*; D038081:Organogenesis / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology*