title: Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction.
abstract: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction.
  
  
  
  The ECLIPse was a multicenter, randomized, double-blind, placebo-controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2-weighted images were available using semiautomated computerized software.
  
  
  
  Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm(3) (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age (P < .001) and serum UA (P = .013) were significantly associated with WMH volume. Age-adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction (r = 0.275, P = .003).
  
  
  
  This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction.
authors.affiliation: Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Han
authors.affiliation: Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea.
authors.forename: Tae Jin
authors.initials: TJ
authors.lastname: Song
authors.affiliation: Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC.
authors.forename: Cheryl D
authors.initials: CD
authors.lastname: Bushnell
authors.affiliation: Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Seo Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Ilsan, Korea.
authors.forename: Jun Hong
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Ilsan, Korea.
authors.forename: Gyu Sik
authors.initials: GS
authors.lastname: Kim
authors.affiliation: Department of Neurology, CHA University College of Medicine, Bundang, Korea.
authors.forename: Ok-Joon
authors.initials: OJ
authors.lastname: Kim
authors.affiliation: Department of Neurology, National Medical Center, Seoul, Korea.
authors.forename: Im-Seok
authors.initials: IS
authors.lastname: Koh
authors.affiliation: Department of Neurology, National Medical Center, Seoul, Korea.
authors.forename: Jong Yun
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Neurology, Sanbon Hospital, Wonkwang University College of Medicine, Sanbon, Korea.
authors.forename: Seung-Han
authors.initials: SH
authors.lastname: Suk
authors.affiliation: Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Korea.|Department of Neurology, Sanbon Hospital, Wonkwang University College of Medicine, Sanbon, Korea.
authors.forename: Sung Ik
authors.initials: SI
authors.lastname: Lee
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyo Suk
authors.initials: HS
authors.lastname: Nam
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyung-Yul
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors.forename: Jae Hyeon
authors.initials: JH
authors.lastname: Park
mesh_terms: D000368:Aged; D000077407:Cilostazol; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow / Q000187:drug effects* / Q000502:physiology*; D013223:Statistics as Topic; D059409:Stroke, Lacunar / Q000097:blood* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D013777:Tetrazoles / Q000627:therapeutic use*; D017585:Ultrasonography, Doppler, Transcranial / Q000187:drug effects; D014527:Uric Acid / Q000097:blood*; D066127:White Matter / Q000000981:diagnostic imaging* / Q000187:drug effects
chemical_list: D013777:Tetrazoles; D014527:Uric Acid; D000077407:Cilostazol
keywords: Lacunar infarcts; uric acid; white matter hyperintensities