title: [RESEARCH PROGRESS OF NOVEL CROSS-LINKING METHODS APPLIED IN BIO-DERIVED MATERIALS].
abstract: OBJECTIVE
  To review the research progress of novel cross-linking methods applied in bio-derived materials.
  
  
  METHODS
  The literature about the latest progress in the cross-linking methods of bio-derived materials was reviewed and analyzed.
  
  
  RESULTS
  The novel cross-linking methods of the bio-derived materials can be divided into chemical methods, physical methods, and biological methods, whose available application and cross-linking properties are greatly depended on their mechanisms. So proper methods should be developed to meet the various application requirements of the materials. A series of studies shows the feasibility and availability of the cross-linked bio-derived materials in the repair and reconstruction of the tissue.
  
  
  CONCLUSIONS
  Bio-derived materials modified by novel cross-linking methods are proved to obtain excellent biocompatibiity and tissue repair ability, better mechanical properties and degradation properties, and so on. Those methods provide researchers more choices to cross-linking materials, which are help to obtain the clinical tissue engineering products.
authors.forename: Da
authors.initials: D
authors.lastname: Lincui
authors.forename: Gong
authors.initials: G
authors.lastname: Mei
authors.forename: Wang
authors.initials: W
authors.lastname: Min
authors.forename: Xie
authors.initials: X
authors.lastname: Huiqi
mesh_terms: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006801:Humans; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents