title: [TREATING SACROILIAC JOINT TUBERCULOSIS WITH RIFAMPICIN-LOADED OsteoSet].
abstract: OBJECTIVE
  To assess the safety, feasibility, and effectiveness of medical calcium sulfate (OsteoSet) mixed with powder for injection of rifampicin after radical debridement in the treatment of sacroiliac joint tuberculosis.
  
  
  METHODS
  A retrospective analysis was made on the clinical data from 27 patients with sacroiliac joint tuberculosis who underwent debridement surgery and local bone graft of OsteoSet artificial bone impregnated with powder for injection of rifampicin between August 2006 and August 2010. There were 10 males and 17 females with an average age of 35.2 years (range, 16-64 years). The mean disease duration was 7.5 months (range, 1.5-16 months). The left sacroiliac joint was involved in 16 cases, the right side in 10 cases, and both sides in 1 case; Of them, 18 cases had iliac fossa abscess and 6 cases of buttocks abscess. According to the classification system by Kim, there were 9 cases of type III and 18 cases of type IV. The preoperative Majeed score was 61.23?6.49, including good in 4 patients, general in 19 patients, and poor in 4 patients.
  
  
  RESULTS
  All patients achieved wound healing by first intention; no complications of pelvic infection, peripheral nerve injury, and lower extremity deep vein thrombosis occurred. Twenty-six patients were followed up 16 months on average (range, 12-24 months). All the patients had normal sense and movement of both lower limbs; no perineum sensory disturbance was found. One case of multi-drug resistant had local recurrence at 3 months after operation, which was cured after adjusting anti-tuberculosis drugs, nutritional support, enhancing immunity with thymopentin, and second operation. Bone union was observed at 10.5 months on average (range, 9-12 months) in 25 patients, and clinical symptoms disappeared with no recurrence or complication, and they returned to previous work. The Majeed score at last follow-up was 92.31 +/- 3.36, showing significant difference when compared with preoperative score (t = -32.76, P=0.00). The results were excellent in 22 patients, good in 4 patients, and the excellent and good rate was 100%, showing signi.ficant difference compared with the preoperative one (chi2=31.93, P=0.00).
  
  
  CONCLUSIONS
  Bone graft interbody fusion surgery with rifampicin loaded OsteoSet is one of the effective methods to treat sacroiliac joint tuberculosis.
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
authors.forename: Helong
authors.initials: H
authors.lastname: Zhang
authors.forename: Dawei
authors.initials: D
authors.lastname: Zhao
authors.forename: Fengsheng
authors.initials: F
authors.lastname: Liu
authors.forename: Shuhong
authors.initials: S
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002133:Calcium Sulfate; D003646:Debridement; D005260:Female; D005593:Fracture Fixation, Internal / Q000379:methods*; D006801:Humans; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D010388:Pelvis; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D012293:Rifampin / Q000627:therapeutic use*; D012446:Sacroiliac Joint / Q000601:surgery*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014394:Tuberculosis, Osteoarticular / Q000628:therapy*; D055815:Young Adult
chemical_list: D000904:Antibiotics, Antitubercular; D012293:Rifampin; D002133:Calcium Sulfate