title: Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA).
abstract: OBJECTIVE
  To describe outcome and prognostic factors, including the effect of radiotherapy, in a consecutive national series of salivary gland adenoid cystic carcinomas.
  
  
  METHODS
  From the national Danish salivary gland carcinoma database in the structure of DAHANCA, 201 patients diagnosed with adenoid cystic carcinoma, and treated with a curative intent, were identified in the period between 1990 and 2005. Variables necessary for statistical analyses were extracted from the database.
  
  
  RESULTS
  The 10-year crude survival and disease specific survival rates were 58% and 75%, respectively. The 10-year locoregional control rate was 70%, and 36% of patients experienced a recurrence during follow-up (median 7.5 years); 18% developed distant metastases (most commonly to the lungs). In multivariate analysis, stage and margin status were both important factors with regards to survival and locoregional control. Radiotherapy did not improve survival, but it did improve the locoregional control rate.
  
  
  CONCLUSIONS
  The treatment of choice is surgery with as wide margins as possible including elective, selective neck dissection. Adjuvant radiotherapy should be considered in patients with incomplete tumor resection, high disease stages, and tumors with a solid growth pattern.
authors.affiliation: Department of ORL-HNS, Odense University Hospital, Denmark. Electronic address: bjoerndal@dadlnet.dk.
authors.forename: Kristine
authors.initials: K
authors.lastname: Bjørndal
authors.affiliation: Department of Pathology, Odense University Hospital, Denmark.
authors.forename: Annelise
authors.initials: A
authors.lastname: Krogdahl
authors.affiliation: Department of Pathology, Rigshospitalet, University Hospital of Copenhagen, Denmark.
authors.forename: Marianne H
authors.initials: MH
authors.lastname: Therkildsen
authors.affiliation: Department of ORL-HNS and Audiology, Rigshospitalet, University Hospital of Copenhagen, Denmark.
authors.forename: Birgitte
authors.initials: B
authors.lastname: Charabi
authors.affiliation: Department of Oncology, Rigshospitalet, University Hospital of Copenhagen, Denmark.
authors.forename: Claus A
authors.initials: CA
authors.lastname: Kristensen
authors.affiliation: Department of Oncology, Herlev Hospital, Denmark.
authors.forename: Elo
authors.initials: E
authors.lastname: Andersen
authors.affiliation: Department of ENT-HNS, Aarhus University Hospital, Denmark.
authors.forename: Sten
authors.initials: S
authors.lastname: Schytte
authors.affiliation: Department of Oncology, Aarhus University Hospital, Denmark.
authors.forename: Hanne
authors.initials: H
authors.lastname: Primdahl
authors.affiliation: Department of Oncology, Odense University Hospital, Denmark.
authors.forename: Jørgen
authors.initials: J
authors.lastname: Johansen
authors.affiliation: Department of ENT-HNS, Aalborg University Hospital, Denmark.
authors.forename: Henrik B
authors.initials: HB
authors.lastname: Pedersen
authors.affiliation: Department of Oncology, Aalborg University Hospital, Denmark.
authors.forename: Lisbeth J
authors.initials: LJ
authors.lastname: Andersen
authors.affiliation: Department of ORL-HNS, Odense University Hospital, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Godballe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000401:mortality / Q000628:therapy; D002648:Child; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012468:Salivary Gland Neoplasms / Q000401:mortality / Q000628:therapy; D016019:Survival Analysis; D055815:Young Adult
keywords: Adenoid cystic carcinoma; National; Prognosis; Radiotherapy; Treatment