title: Dapsone Therapy for Pustular Psoriasis: Case Series and Review of the Literature.
abstract: BACKGROUND
  Pustular psoriasis is an uncommon psoriasis variant, clinically characterized as small sterile pustules on an erythematous base. Evidence for therapy is lacking, and many currently employed systemic therapeutics carry risks of significant side effects, without specifically targeting disease etiology which includes the aggregation of neutrophils.
  
  
  METHODS
  We report therapy with the anti-neutrophil agent dapsone in 5 patients with pustular psoriasis and provide a brief review of the literature. Four patients responded to oral dapsone and 1 to topical dapsone therapy. All 5 patients had previously failed multiple topical and systemic treatments. In 2 cases, oral dapsone allowed for the discontinuation of other systemic agents. One patient stopped oral dapsone due to a side effect of sleep disturbance.
  
  
  CONCLUSIONS
  Dapsone has a much safer side effect profile and may target the pathophysiology of pustular psoriasis more directly than many other systemic agents. As such, dapsone should be considered for the treatment of patients with pustular psoriasis.
authors.affiliation: Harvard Medical School, Brigham and Women's Hospital, Boston, Mass., USA.
authors.forename: Johanna S
authors.initials: JS
authors.lastname: Sheu
authors.forename: Sherrie J
authors.initials: SJ
authors.lastname: Divito
authors.forename: Monica
authors.initials: M
authors.lastname: Enamandram
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Merola
mesh_terms: D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000627:therapeutic use*; D003622:Dapsone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy*
chemical_list: D000962:Antimalarials; D003622:Dapsone