title: [Pathophysiology of cluster headache].
abstract: The aetiology of cluster headache is partially unknown. Three areas are involved in the pathogenesis of cluster headache: the trigeminal nociceptive pathways, the autonomic system and the hypothalamus. The cluster headache attack involves activation of the trigeminal autonomic reflex. A dysfunction located in posterior hypothalamic gray matter is probably pivotal in the process. There is a probable association between smoke exposure, a possible genetic predisposition and the development of cluster headache.
authors.affiliation: CHU Timone, pôle neurosciences cliniques, centre d'évaluation et de traitement de la douleur, rue Saint-Pierre, 13385 Marseille, France. Electronic address: adonnet@ap-hm.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Donnet
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D001341:Autonomic Nervous System / Q000503:physiopathology; D002536:Cerebral Arteries / Q000294:innervation; D002550:Cerebral Veins / Q000294:innervation; D002940:Circadian Rhythm / Q000502:physiology; D003027:Cluster Headache / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D004388:Dura Mater / Q000098:blood supply; D005156:Facial Neuralgia / Q000209:etiology / Q000503:physiopathology; D056726:Genetic Association Studies; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D008959:Models, Neurological; D059906:Neuroimaging; D009479:Neuropeptides / Q000378:metabolism; D012018:Reflex; D012906:Smoke / Q000009:adverse effects; D012668:Trigeminal Ganglion / Q000503:physiopathology; D014276:Trigeminal Nerve / Q000503:physiopathology; D014664:Vasodilation / Q000502:physiology
chemical_list: D006728:Hormones; D009479:Neuropeptides; D012906:Smoke