title: Molecular imprinting method for fabricating novel glucose sensor: polyvinyl acetate electrode reinforced by MnO2/CuO loaded on graphene oxide nanoparticles.
abstract: An enzyme free glucose sensor was prepared by a molecular imprinting method (MIP). The procedure was developed by in situ preparation of a new polyvinyl acetate (PVA) electrode reinforced by MnO2/CuO loaded on graphene oxide (GO) nanoparticles (PVA/MnO2@GO/CuO). The nanocomposite was modified in the presence of glucose and then imprinted. A carbone paste method with voltammetry was used in the fabrication of the sensor from prepared MIP nanocomposite. PVA/MnO2@GO/CuO electrode was characterized by X-ray diffraction, FT-IR spectroscopy and scanning electron microscopy. Electrocatalytic activity of the electrode toward glucose oxidation was then investigated by cyclic voltammetry in alkaline medium. The results show that the response of PVA/MnO2@GO/CuO MIP is much higher than PVA/MnO2@GO/CuO non-imprinted electrode toward glucose oxidation. The detection limit was 53μM, and the sensor responses are linear for concentrations from 0.5 to 4.4mM. Relative standard deviations for intra- and inter-day determination were less than 6.0%. The relative recoveries for different samples were 96%.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Zanjan, P.O. Box 45371-38791, Zanjan, Iran.
authors.forename: Mohammad Masoudi
authors.initials: MM
authors.lastname: Farid
authors.affiliation: Department of Chemistry, Faculty of Science, University of Zanjan, P.O. Box 45371-38791, Zanjan, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Goudini
authors.affiliation: Department of Chemistry, Faculty of Science, University of Zanjan, P.O. Box 45371-38791, Zanjan, Iran.
authors.forename: Farideh
authors.initials: F
authors.lastname: Piri
authors.affiliation: Department of Environmental Science, Faculty of Science, University of Zanjan, P.O. Box 45371-38791, Zanjan, Iran.
authors.forename: Abbasali
authors.initials: A
authors.lastname: Zamani
authors.affiliation: Department of Chemistry, Faculty of Science, University of Zanjan, P.O. Box 45371-38791, Zanjan, Iran. Electronic address: saadati@znu.ac.ir.
authors.forename: Fariba
authors.initials: F
authors.lastname: Saadati
mesh_terms: D003300:Copper / Q000737:chemistry*; D004566:Electrodes; D005947:Glucose / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry; D017895:Manganese Compounds / Q000737:chemistry*; D054802:Molecular Imprinting / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D011145:Polyvinyls / Q000032:analysis
chemical_list: D017895:Manganese Compounds; D010087:Oxides; D011145:Polyvinyls; C013215:polyvinyl acetate; C027424:manganese oxide; D006108:Graphite; D003300:Copper; D005947:Glucose; C000520:cuprous oxide
keywords: Ammonium persulfate (PubChem CID: 62648); Clinical chemistry; Cyclic voltammetry; Enzyme free sensor; Glucose (PubChem CID: 53782692); Graphite (PubChem CID: 5462310); Nanocomposite; Potassium permanganate (PubChem CID: 516875); Sodium dodecyl sulfate (PubChem CID: 3423265); Vinyl acetate (PubChem CID: 7904)