title: Impact of MR Acquisition Parameters on DTI Scalar Indexes: A Tractography Based Approach.
abstract: Acquisition parameters play a crucial role in Diffusion Tensor Imaging (DTI), as they have a major impact on the values of scalar measures such as Fractional Anisotropy (FA) or Mean Diffusivity (MD) that are usually the focus of clinical studies based on white matter analysis. This paper presents an analysis on the impact of the variation of several acquisition parameters on these scalar measures with a novel double focus. First, a tractography-based approach is employed, motivated by the significant number of clinical studies that are carried out using this technique. Second, the consequences of simultaneous changes in multiple parameters are analyzed: number of gradient directions, b-value and voxel resolution. Results indicate that the FA is most affected by changes in the number of gradients and voxel resolution, while MD is specially influenced by variations in the b-value. Even if the choice of a tractography algorithm has an effect on the numerical values of the final scalar measures, the evolution of these measures when acquisition parameters are modified is parallel.
authors.affiliation: Laboratorio de Procesado de Imagen, Departamento de Teoría de la Señal y Comunicaciones e Ingeniería Telemática/ETSI Telecomunicación, Universidad de Valladolid, Valladolid, España.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Barrio-Arranz
authors.affiliation: Laboratorio de Procesado de Imagen, Departamento de Teoría de la Señal y Comunicaciones e Ingeniería Telemática/ETSI Telecomunicación, Universidad de Valladolid, Valladolid, España.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: de Luis-García
authors.affiliation: Laboratorio de Procesado de Imagen, Departamento de Teoría de la Señal y Comunicaciones e Ingeniería Telemática/ETSI Telecomunicación, Universidad de Valladolid, Valladolid, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Tristán-Vega
authors.affiliation: Laboratorio de Procesado de Imagen, Departamento de Teoría de la Señal y Comunicaciones e Ingeniería Telemática/ETSI Telecomunicación, Universidad de Valladolid, Valladolid, España.
authors.forename: Marcos
authors.initials: M
authors.lastname: Martín-Fernández
authors.affiliation: Laboratorio de Procesado de Imagen, Departamento de Teoría de la Señal y Comunicaciones e Ingeniería Telemática/ETSI Telecomunicación, Universidad de Valladolid, Valladolid, España.
authors.forename: Santiago
authors.initials: S
authors.lastname: Aja-Fernández
mesh_terms: D000328:Adult; D000465:Algorithms; D016880:Anisotropy; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D066127:White Matter / Q000166:cytology; D055815:Young Adult