title: Mixed Hybrid Lipid/Polymer Vesicles as a Novel Membrane Platform.
abstract: Vesicles can be individually fabricated from naturally occurring lipid or synthetic block copolymer molecules via self-assembly in aqueous solutions; the blending of both vesicle-forming amphiphiles leads to the formation of hybrid membranes. Their final stabilities and lateral morphologies are strongly determined by the molar composition, size, and charge properties of the interacting components as well as by the lipid chain melting temperature. Upon merging the best properties of lipo- and polymersomal membranes, hybrid lipid/polymer vesicles represent a new scaffold for medical applications combining, e.g., combining the biocompatibility of liposomes with the high thermal and mechanical stability and functional variability of polymersomes within a single vesicle type. Up to now, several hybrid membrane systems and their corresponding vesicular morphologies have been studied, highlighting the attractive properties and features useful in selective delivery receptor scaffolding.
authors.affiliation: Martin-Luther University Halle-Wittenberg, Chair of Macromolecular Chemistry, Faculty of Natural Sciences II (Chemistry, Physics and Mathematics), Institute of Chemistry, D-06120, Halle (Saale), Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schulz
authors.affiliation: Martin-Luther University Halle-Wittenberg, Chair of Macromolecular Chemistry, Faculty of Natural Sciences II (Chemistry, Physics and Mathematics), Institute of Chemistry, D-06120, Halle (Saale), Germany.
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Binder
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008567:Membranes, Artificial
chemical_list: D008055:Lipids; D008567:Membranes, Artificial
keywords: hybrid vesicles; lipids; membranes; polymersomes; vesicles