title: Clinical Effect of Antioxidant Glasses Containing Extracts of Medicinal Plants in Patients with Dry Eye Disease: A Multi-Center, Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
abstract: OBJECTIVE
  To investigate the clinical efficacy and safety of wearable antioxidant glasses containing extracts of medicinal plants in patients with mild dry eye disease (DED).
  
  
  METHODS
  Fifty patients with mild DED were randomly assigned to wear either extracts of antioxidant medicinal plants containing (N = 25) or placebo glasses (N = 25). Patients wore the glasses for 15 min three times daily. The ocular surface disease index (OSDI) score, tear film break up time (BUT), and Schirmer's test were evaluated and compared within the group and between the groups at baseline, 4 weeks, and 8 weeks after treatment.
  
  
  RESULTS
  OSDI score and tear film BUT were significantly improved in the treatment group at 4 and 8 weeks after wearing glasses (all P < 0.001). Compared to the placebo group, the OSDI scores were significantly lower in the treatment group at 8 weeks (P = 0.007). The results of the Schirmer's test showed significant improvement in the treatment group at 4 weeks (P = 0.035), however there were no significant differences between the other groups or within the groups. No adverse events were reported during the study.
  
  
  CONCLUSIONS
  Antioxidant glasses containing extracts of medicinal plants were effective in improving in DED both subjectively and objectively. Wearing antioxidants glasses might be a safe and adjunctive therapeutic option for DED.
  
  
  BACKGROUND
  ISRCTN registry 71217488.
authors.affiliation: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors.forename: Won
authors.initials: W
authors.lastname: Choi
authors.affiliation: Department of Ophthalmology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Jae Chan
authors.initials: JC
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Won Soo
authors.initials: WS
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors.forename: Han Jin
authors.initials: HJ
authors.lastname: Oh
authors.affiliation: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors.forename: Jee Myung
authors.initials: JM
authors.lastname: Yang
authors.affiliation: Department of Dermatology, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors.forename: Jee Bum
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea.
authors.forename: Kyung Chul
authors.initials: KC
authors.lastname: Yoon
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D004311:Double-Blind Method; D015352:Dry Eye Syndromes / Q000188:drug therapy*; D005260:Female; D005898:Glass; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts