title: The effects of non-ionic polymeric surfactants on the cleaning of biofouled hydrogel materials.
abstract: Block co-polymer surfactants have been used for cleaning hydrogel medical devices that contact the body (e.g., contact lenses) because of their biocompatibility. This work examined the relationship between concentration and detergency of two non-ionic polymeric surfactants (Pluronic F127 and Triton X-100) for cleaning protein soil, with anionic surfactants (sodium dodecyl sulfate and sodium laureth sulfate) as positive controls. Surface plasmon resonance was used to quantify removal of simulated tear soil from self-assembled monolayer surfaces, and a microplate format was used to study the removal of fluorescently labeled soil proteins from contact lenses. While detergency increased as a function of concentration for anionic surfactants, it decreased with concentration for the two polymeric surfactants. The fact that the protein detergency of some non-ionic polymeric surfactants did not increase with concentration above the critical micelle concentration could have implications for optimizing the tradeoff between detergency and biocompatibility.
authors.affiliation: a Department of Biomedical Engineering , The George Washington University , Washington , DC , USA.
authors.forename: Allan
authors.initials: A
authors.lastname: Guan
authors.affiliation: a Department of Biomedical Engineering , The George Washington University , Washington , DC , USA.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Li
authors.affiliation: b Division of Biology, Chemistry and Materials Science , United States Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories , Silver Spring , MD , USA.
authors.forename: K Scott
authors.initials: KS
authors.lastname: Phillips
mesh_terms: D057219:Biofouling / Q000517:prevention & control*; D003261:Contact Lenses / Q000382:microbiology*; D003902:Detergents / Q000737:chemistry; D020100:Hydrogels; D065346:Lubricant Eye Drops / Q000737:chemistry; D017830:Octoxynol / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000031:analogs & derivatives / Q000737:chemistry; D012996:Solutions; D020349:Surface Plasmon Resonance; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D003902:Detergents; D020100:Hydrogels; D065346:Lubricant Eye Drops; D012996:Solutions; D013501:Surface-Active Agents; D020442:Poloxamer; D012967:Sodium Dodecyl Sulfate; D017830:Octoxynol; C408148:sodium laureth sulfate
keywords: block copolymer; contact lens; critical micelle concentration (CMC); detergency; hydrogel; multipurpose solution (MPS)