title: Comparison of non-electrophoresis grade with electrophoresis grade BIS in NIPAM polymer gel preparation.
abstract: BACKGROUND
  The main objective of this study was to investigate the possibility of replacing electrophoresis cross-linker with non-electrophoresis N, N'-methylenebisacrylamide (BIS) in N-isopropyl acrylamide (NIPAM) polymer gel and its possible effect on dose response.
  
  
  METHODS
  NIPAM polymer gel was prepared from non-electrophoresis grade BIS and the relaxation rate (R2) was measured by MR imaging after exposing the gel to gamma radiation from Co-60 source. To compare the response of this gel with the one that contains electrophoresis grade BIS, two sets of NIPAM gel were prepared using electrophoresis and non-electrophoresis BIS and irradiated to different gamma doses.
  
  
  RESULTS
  It was found that the dose-response of NIPAM gel made from the non-electrophoresis grade BIS is coincident with that of electrophoresis grade BIS.
  
  
  CONCLUSIONS
  Taken all, it can be concluded that the non-electrophoresis grade BIS not only is a suitable alternative for the electrophoresis grade BIS but also reduces the cost of gel due to its lower price.
authors.affiliation: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Medical Education Research Center, Tabriz, Iran.
authors.forename: Roghayeh
authors.initials: R
authors.lastname: Khodadadi
authors.affiliation: Medical Education Research Center, Tabriz, Iran.
authors.forename: Azim
authors.initials: A
authors.lastname: Khajeali
authors.affiliation: Medical Education Research Center, Tabriz, Iran ; Faculty of Medicine, Department of Medical Physics, Tabriz University of Medical Sciences, Tabriz, Iran ; Imam Reza hospital, Radiotherapy Department, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Farajollahi
authors.affiliation: Faculty of Paramedicine, Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Hajalioghli
authors.affiliation: Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Noorallah
authors.initials: N
authors.lastname: Raeisi
keywords: Cross linker agent; N, N′-Methylenebisacrylamide (BIS); NIPAM gel; Polymer gel dosimetry