title: Years of potential life lost for brain and CNS tumors relative to other cancers in adults in the United States, 2010.
abstract: BACKGROUND
  Years of potential life lost (YPLL) complement incidence and survival rates by measuring how much a patient's life is likely to be shortened by his or her cancer. In this study, we examine the impact of death due to brain and other central nervous system (CNS) tumors compared to other common cancers in adults by investigating the YPLL of adults in the United States.
  
  
  METHODS
  Mortality and life table data were obtained from the Centers for Disease Control and Prevention's National Center for Health Statistics Vital Statistics Data for 2010. The study population included individuals aged 20 years or older at death who died from one of the selected cancers. YPLL was calculated by taking an individual's age at death and finding the corresponding expected remaining years of life using life table data.
  
  
  RESULTS
  The cancers with the greatest mean YPLL were other malignant CNS tumors (20.65), malignant brain tumors (19.93), and pancreatic cancer (15.13) for males and malignant brain tumors (20.31), breast cancer (18.78), and other malignant CNS tumors (18.36) for females. For both sexes, non-Hispanic whites had the lowest YPLL, followed by non-Hispanic blacks, and Hispanics.
  
  
  CONCLUSIONS
  Malignant brain and other CNS tumors have the greatest mean YPLL, thereby reflecting their short survival time post diagnosis. These findings will hopefully motivate more research into mitigating the impact of these debilitating tumors.
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio (C.R.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (H.G., Q.T.O., J.S.B.-S.); Central Brain Tumor Registry of the United States, Hinsdale, Illinois (H.G., Q.T.O., C. K., J.S.B.-S.).
authors.forename: Chaturia
authors.initials: C
authors.lastname: Rouse
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio (C.R.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (H.G., Q.T.O., J.S.B.-S.); Central Brain Tumor Registry of the United States, Hinsdale, Illinois (H.G., Q.T.O., C. K., J.S.B.-S.).
authors.forename: Haley
authors.initials: H
authors.lastname: Gittleman
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio (C.R.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (H.G., Q.T.O., J.S.B.-S.); Central Brain Tumor Registry of the United States, Hinsdale, Illinois (H.G., Q.T.O., C. K., J.S.B.-S.).
authors.forename: Quinn T
authors.initials: QT
authors.lastname: Ostrom
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio (C.R.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (H.G., Q.T.O., J.S.B.-S.); Central Brain Tumor Registry of the United States, Hinsdale, Illinois (H.G., Q.T.O., C. K., J.S.B.-S.).
authors.forename: Carol
authors.initials: C
authors.lastname: Kruchko
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio (C.R.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (H.G., Q.T.O., J.S.B.-S.); Central Brain Tumor Registry of the United States, Hinsdale, Illinois (H.G., Q.T.O., C. K., J.S.B.-S.).
authors.forename: Jill S
authors.initials: JS
authors.lastname: Barnholtz-Sloan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000453:epidemiology / Q000401:mortality*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000401:mortality; D016543:Central Nervous System Neoplasms / Q000453:epidemiology / Q000401:mortality*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality*; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000401:mortality; D012737:Sex Factors; D016019:Survival Analysis; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: CBTRUS; NCHS; central nervous system tumors; years of potential life lost