title: The effects of Crocus sativus (saffron) and its constituents on nervous system: A review.
abstract: Saffron or Crocus sativus L. (C. sativus) has been widely used as a medicinal plant to promote human health, especially in Asia. The main components of saffron are crocin, picrocrocin and safranal. The median lethal doses (LD50) of C. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. Saffron has been suggested to be effective in the treatment of a wide range of disorders including coronary artery diseases, hypertension, stomach disorders, dysmenorrhea and learning and memory impairments. In addition, different studies have indicated that saffron has anti-inflammatory, anti-atherosclerotic, antigenotoxic and cytotoxic activities. Antitussive effects of stigmas and petals of C. sativus and its components, safranal and crocin have also been demonstrated. The anticonvulsant and anti-Alzheimer properties of saffron extract were shown in human and animal studies. The efﬁcacy of C. sativus in the treatment of mild to moderate depression was also reported in clinical trial. Administration of C. sativus and its constituents increased glutamate and dopamine levels in the brain in a dose-dependent manner. It also interacts with the opioid system to reduce withdrawal syndrome. Therefore, in the present article, the effects of C. sativus and its constituents on the nervous system and the possible underlying mechanisms are reviewed. Our literature review showed that C. sativus and its components can be considered as promising agents in the treatment of nervous system disorders.
authors.affiliation: Neurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Postal Code 9177948564, Iran ; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Khazdair
authors.affiliation: Neurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Postal Code 9177948564, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Boskabady
authors.affiliation: Neurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Postal Code 9177948564, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Hosseini
authors.affiliation: Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Rezaee
authors.affiliation: Center of Toxicology Science and Research, Division of Morphology, Medical School, University of Crete, Heraklion, Crete, Greece.
authors.forename: Aristidis
authors.initials: A
authors.lastname: M Tsatsakis
keywords: Crocin; Crocus sativus; Nervous system; Saffron; Safranal