title: [Therapeutic Implication Targeting for Cancer Stem Cells].
abstract: Cancer has been viewed as a heterogeneous population of cells.While the large majority of cells that constituting tumors are differentiated, and eventually stop dividing, only a minority population of cells, termed cancer stem cells, is capable of unlimited self-renewal and multi-differentiation, just like somatic stem cells in normal tissues.Cancer stem cells have been identified in a variety of cancers of the blood, brain, stomach, colon, and pancreas.In this review we present current evidence supporting the cancer stem cell model of tumor progression, and discuss the experimental and therapeutic implications.
authors.affiliation: Dept. of Gastroenterological Surgery, Osaka University, Graduate School of Medicine.
authors.forename: Kozo
authors.initials: K
authors.lastname: Noguchi
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Konno
authors.forename: Naohiro
authors.initials: N
authors.lastname: Nishida
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Jun
authors.initials: J
authors.lastname: Koseki
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Eguchi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Taro
authors.initials: T
authors.lastname: Satoh
authors.forename: Hideshi
authors.initials: H
authors.lastname: Ishii
mesh_terms: D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000166:cytology