title: Xenon Blocks Neuronal Injury Associated with Decompression.
abstract: Despite state-of-the-art hyperbaric oxygen (HBO) treatment, about 30% of patients suffering neurologic decompression sickness (DCS) exhibit incomplete recovery. Since the mechanisms of neurologic DCS involve ischemic processes which result in excitotoxicity, it is likely that HBO in combination with an anti-excitotoxic treatment would improve the outcome in patients being treated for DCS. Therefore, in the present study, we investigated the effect of the noble gas xenon in an ex vivo model of neurologic DCS. Xenon has been shown to provide neuroprotection in multiple models of acute ischemic insults. Fast decompression compared to slow decompression induced an increase in lactate dehydrogenase (LDH), a well-known marker of sub-lethal cell injury. Post-decompression administration of xenon blocked the increase in LDH release induced by fast decompression. These data suggest that xenon could be an efficient additional treatment to HBO for the treatment of neurologic DCS.
authors.affiliation: Institut de Recherche Biomédicale des Armées, Équipe Résidente de Recherche Subaquatique Opérationnelle, BP 600 Toulon Cedex 9, France.
authors.forename: Jean-Eric
authors.initials: JE
authors.lastname: Blatteau
authors.affiliation: Centre de recherche Hôtel-Dieu de Lévis, CSSS Alphonse-Desjardins, Lévis, QC, Canada.|Université Laval, Département d'Anesthésiologie, Québec, QC, Canada.
authors.forename: Hélène N
authors.initials: HN
authors.lastname: David
authors.affiliation: Institut de Recherche Biomédicale des Armées, Équipe Résidente de Recherche Subaquatique Opérationnelle, BP 600 Toulon Cedex 9, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vallée
authors.affiliation: Institut de Recherche Biomédicale des Armées, Équipe Résidente de Recherche Subaquatique Opérationnelle, BP 600 Toulon Cedex 9, France.
authors.forename: Cedric
authors.initials: C
authors.lastname: Meckler
authors.affiliation: Institut de Recherche Biomédicale des Armées, Équipe Résidente de Recherche Subaquatique Opérationnelle, BP 600 Toulon Cedex 9, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Demaistre
authors.affiliation: Institut de Recherche Biomédicale des Armées, Équipe Résidente de Recherche Subaquatique Opérationnelle, BP 600 Toulon Cedex 9, France.|Laboratoire motricité humaine, éducation, sport, santé (LAMHESS), Université de Toulon UFR STAPS, BP 20132, 83957 La Garde, France.
authors.forename: Kate
authors.initials: K
authors.lastname: Lambrechts
authors.affiliation: Institut de Recherche Biomédicale des Armées, Équipe Résidente de Recherche Subaquatique Opérationnelle, BP 600 Toulon Cedex 9, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Risso
authors.affiliation: Institut de Recherche Biomédicale des Armées, Équipe Résidente de Recherche Subaquatique Opérationnelle, BP 600 Toulon Cedex 9, France.|Université Laval, Département d'Anesthésiologie, Québec, QC, Canada.|Normandie-Université, Université de Caen - Basse Normandie, Caen, France.
authors.forename: Jacques H
authors.initials: JH
authors.lastname: Abraini
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D003665:Decompression Sickness / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D004195:Disease Models, Animal; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D051381:Rats; D013997:Time Factors; D014978:Xenon / Q000008:administration & dosage*
chemical_list: D018696:Neuroprotective Agents; D014978:Xenon; D007770:L-Lactate Dehydrogenase