title: Recent Advances in Drug Discovery from South African Marine Invertebrates.
abstract: Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm Cephalodiscus gilchristi, the ascidian Lissoclinum sp. and the sponge Topsentia pachastrelloides, are presented. Recent reports of the bioactivity and synthesis of the anti-cancer secondary metabolites cephalostatin and mandelalides (from C. gilchristi and Lissoclinum sp., respectively) and various analogues are presented. The threat of drug-resistant pathogens, e.g., methicillin-resistant Staphylococcus aureus (MRSA), is assuming greater global significance, and medicinal chemistry strategies to exploit the potent MRSA PK inhibition, first revealed by two marine secondary metabolites, cis-3,4-dihydrohamacanthin B and bromodeoxytopsentin from T. pachastrelloides, are compared.
authors.affiliation: Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, South Africa. mdavies-coleman@uwc.ac.za.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Davies-Coleman
authors.affiliation: Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa. C.Veale@ru.ac.za.
authors.forename: Clinton G L
authors.initials: CG
authors.lastname: Veale
mesh_terms: D000818:Animals; D059001:Aquatic Organisms; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D011077:Polychaeta / Q000378:metabolism*; D011161:Porifera / Q000378:metabolism*; D064210:Secondary Metabolism; D013019:South Africa; D014561:Urochordata / Q000378:metabolism*
keywords: MRSA PK; bisindole alkaloids; cephalostatin; mandelalide; methicillin resistant Staphylococcus aureus