title: Metabolic effects of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency.
abstract: OBJECTIVE
  Epidemiological studies suggest that vitamin D status influences type 2 diabetes mellitus. We investigate the metabolic effects of vitamin D.
  
  
  METHODS
  We studied consecutive type 2 diabetic patients without insulin therapy with vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) lower than 20ng/ml). They were treated with 16,000IU of calcifediol orally once a week for a minimum of 8 weeks.
  
  
  RESULTS
  Twenty eight patients were treated for a mean time of 84.1 days (range 56 to 120 days). All patients achieved serum levels of 25(OH)D higher than 20ng/ml. There was a significant reduction in fasting glucose (145.6±35.5 vs. 131.7±30.4mg/dl, p<0.001). There were small non-significant reductions in HbA1c, fasting insulin and Homeostasis Model Assesment (HOMA)-insulin resistance (IR). There were small non-significant increases in HOMA-insulin sensitivity (S) and HOMA-beta cell function (B) and a small significant increase in Quantitative Insulin Sensitivity Check Index (QUICKI).
  
  
  CONCLUSIONS
  Correction of vitamin D deficiency in type 2 diabetic patients decreases fasting glucose. Our results do not rule out improvements in metabolic control, insulin-resistance and function of the beta cell.
authors.affiliation: Internal Medicine Service, Hospital Ciudad de Coria, Coria (Cáceres), Spain. Electronic address: jm.calvo@orangemail.es.
authors.forename: José María
authors.initials: JM
authors.lastname: Calvo-Romero
authors.affiliation: Internal Medicine Service, Hospital Ciudad de Coria, Coria (Cáceres), Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Ramiro-Lozano
mesh_terms: D000368:Aged; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D014807:Vitamin D / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D014807:Vitamin D; C517652:hemoglobin A1c protein, human
keywords: Insulin resistance; Type 2 diabetes mellitus; Vitamin D