title: Orthogonal Recognition Processes Drive the Assembly and Replication of a [2]Rotaxane.
abstract: Within a small, interconnected reaction network, orthogonal recognition processes drive the assembly and replication of a [2]rotaxane. Rotaxane formation is governed by a central, hydrogen-bonding-mediated binding equilibrium between a macrocycle and a linear component, which associate to give a reactive pseudorotaxane. Both the pseudorotaxane and the linear component undergo irreversible, recognition-mediated 1,3-dipolar cycloaddition reactions with a stoppering maleimide group, forming rotaxane and thread, respectively. As a result of these orthogonal recognition-mediated processes, the rotaxane and thread can act as auto-catalytic templates for their own formation and also operate as cross-catalytic templates for each other. However, the interplay between the recognition and reaction processes in this reaction network results in the formation of undesirable pseudorotaxane complexes, causing thread formation to exceed rotaxane formation in the current experimental system. Nevertheless, in the absence of competitive macrocycle-binding sites, realization of a replicating network favoring formation of rotaxane is possible.
authors.affiliation: School of Chemistry and EaStCHEM, University of St Andrews , North Haugh, St Andrews KY16 9ST, United Kingdom.
authors.forename: Tamara
authors.initials: T
authors.lastname: Kosikova
authors.affiliation: School of Chemistry and EaStCHEM, University of St Andrews , North Haugh, St Andrews KY16 9ST, United Kingdom.|School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia , 43600 Bangi, Selangor, Malaysia.
authors.forename: Nurul Izzaty
authors.initials: NI
authors.lastname: Hassan
authors.affiliation: School of Chemistry and EaStCHEM, University of St Andrews , North Haugh, St Andrews KY16 9ST, United Kingdom.
authors.forename: David B
authors.initials: DB
authors.lastname: Cordes
authors.affiliation: School of Chemistry and EaStCHEM, University of St Andrews , North Haugh, St Andrews KY16 9ST, United Kingdom.
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
authors.affiliation: School of Chemistry and EaStCHEM, University of St Andrews , North Haugh, St Andrews KY16 9ST, United Kingdom.
authors.forename: Douglas
authors.initials: D
authors.lastname: Philp