title: Iridium-catalyzed enantioselective allylation of silyl enol ethers derived from ketones and α,β-unsaturated ketones.
abstract: The unified Ir-catalyzed enantioselective allylic substitution reactions of silyl enol ethers derived from ketones and α,β-unsaturated ketones with branched, racemic allylic alcohols are described. This transformation is catalyzed by the Carreira system and proceeds without fluoride, and with high ee and b : l ratio. The synthetic utility of this method was illustrated by the concise enantioselective total synthesis of marine natural products calyxolane A, B and by the assignment of the absolute configuration of calyxolane A.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. yangyurong@mail.kib.ac.cn weikun@mail.kib.ac.cn.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liang
authors.forename: Kun
authors.initials: K
authors.lastname: Wei
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Yang