title: Characteristics and outcomes of patients admitted to Spanish ICU: A prospective observational study from the ENVIN-HELICS registry (2006-2011).
abstract: OBJECTIVE
  To describe the case-mix of patients admitted to intensive care units (ICUs) in Spain during the period 2006-2011 and to assess changes in ICU mortality according to severity level.
  
  
  METHODS
  Secondary analysis of data obtained from the ENVN-HELICS registry. Observational prospective study.
  
  
  METHODS
  Spanish ICU.
  
  
  METHODS
  Patients admitted for over 24h.
  
  
  METHODS
  None.
  
  
  METHODS
  Data for each of the participating hospitals and ICUs were recorded, as well as data that allowed to knowing the case-mix and the individual outcome of each patient. The study period was divided into two intervals, from 2006 to 2008 (period 1) and from 2009 to 2011 (period 2). Multilevel and multivariate models were used for the analysis of mortality and were performed in each stratum of severity level.
  
  
  RESULTS
  The study population included 142,859 patients admitted to 188 adult ICUs. There was an increase in the mean age of the patients and in the percentage of patients >79 years (11.2% vs. 12.7%, P<0.001). Also, the mean APACHE II score increased from 14.35±8.29 to 14.72±8.43 (P<0.001). The crude overall intra-UCI mortality remained unchanged (11.4%) but adjusted mortality rate in patients with APACHE II score between 11 and 25 decreased modestly in recent years (12.3% vs. 11.6%, odds ratio=0.931, 95% CI 0.883-0.982; P=0.008).
  
  
  CONCLUSIONS
  This study provides observational longitudinal data on case-mix of patients admitted to Spanish ICUs. A slight reduction in ICU mortality rate was observed among patients with intermediate severity level.
authors.affiliation: Service of Intensive Care Medicine, Hospital de Galdakao-Usansolo, B° Labeaga s/n, 48960 Galdakao, Bizkaia, Spain. Electronic address: pedromaria.olaecheaastigarrag@osakidetza.net.
authors.forename: P M
authors.initials: PM
authors.lastname: Olaechea
authors.affiliation: Service of Intensive Care Medicine, Hospital Universitari del Mar, Universitat Autònoma de Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Álvarez-Lerma
authors.affiliation: Service of Intensive Care Medicine, Hospital Arnau de Vilanova. Lleida, Institut de Reserca Biomèdica (IRB) y Universitat Autónoma de Barcelona, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Palomar
authors.affiliation: Intensive Care Unit, Hospital Universitario La Fe, Valencia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Gimeno
authors.affiliation: Service of Intensive Care Medicine, Hospital Universitari del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: M P
authors.initials: MP
authors.lastname: Gracia
authors.affiliation: Service of Intensive Care Medicine, Hospital de Galdakao-Usansolo, Galdakao, Bizkaia, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Mas
authors.affiliation: Service of Intensive Care Medicine, Hospital de Galdakao-Usansolo, Galdakao, Bizkaia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Rivas
authors.affiliation: Service of Intensive Care Medicine, Hospital Universitario Cruces, Barakaldo, Bizkaia, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Seijas
authors.affiliation: Service of Intensive Care Medicine, Hospital Universitari Arnau de Vilanova, Lleida, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Nuvials
authors.affiliation: Service of Intensive Care Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Catalán
mesh_terms: D018806:APACHE; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003428:Cross Infection / Q000453:epidemiology; D003953:Diagnosis-Related Groups; D005260:Female; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D013030:Spain / Q000453:epidemiology; D016896:Treatment Outcome
keywords: Case-mix; Critically ill patients; ENVIN-HELICS registry; Epidemiological registry; Gravedad; Infección nosocomial; Intensive care units; Mortalidad; Mortality; Nosocomial infection; Pacientes críticos; Registro ENVIN-HELICS; Registro epidemiológico; Severity; Unidad de cuidados intensivos