title: Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis.
abstract: The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
authors.forename: Dongyan
authors.initials: D
authors.lastname: Tan
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA, USA.|Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Neil B
authors.initials: NB
authors.lastname: Blok
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA, USA.|Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Tom A
authors.initials: TA
authors.lastname: Rapoport
authors.affiliation: The Rockefeller University, New York, NY, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Walz
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases / Q000737:chemistry* / Q000378:metabolism*; D020285:Cryoelectron Microscopy; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism; D020675:Peroxisomes / Q000201:enzymology*; D011487:Protein Conformation; D054730:Protein Interaction Domains and Motifs; D021122:Protein Subunits; D055672:Static Electricity
chemical_list: D008565:Membrane Proteins; D009097:Multienzyme Complexes; D021122:Protein Subunits; D000251:Adenosine Triphosphatases; D000074183:ATPases Associated with Diverse Cellular Activities; C111808:PEX1 protein, human; C490759:PEX6 protein, human
keywords: AAA ATPases; Pex1-Pex6 complex; cryo-electron microscopy; peroxisome biogenesis; single-particle analysis