title: Aspergillus mulundensis sp. nov., a new species for the fungus producing the antifungal echinocandin lipopeptides, mulundocandins.
abstract: The invalidly published name Aspergillus sydowii var. mulundensis was proposed for a strain of Aspergillus that produced new echinocandin metabolites designated as the mulundocadins. Reinvestigation of this strain (Y-30462=DSMZ 5745) using phylogenetic, morphological, and metabolic data indicated that it is a distinct and novel species of Aspergillus sect. Nidulantes. The taxonomic novelty, Aspergillus mulundensis, is introduced for this historically important echinocandin-producing strain. The closely related A. nidulans FGSC A4 has one of the most extensively characterized secondary metabolomes of any filamentous fungus. Comparison of the full-genome sequences of DSMZ 5745 and FGSC A4 indicated that the two strains share 33 secondary metabolite biosynthetic gene clusters. These shared gene clusters represent ~45% of the total secondary metabolome of each strain, thus indicating a high level intraspecific divergence in terms of secondary metabolism.
authors.affiliation: Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centre at Houston, Houston, TX, USA.
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Bills
authors.affiliation: Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centre at Houston, Houston, TX, USA.
authors.forename: Qun
authors.initials: Q
authors.lastname: Yue
authors.affiliation: Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centre at Houston, Houston, TX, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centre at Houston, Houston, TX, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centre at Houston, Houston, TX, USA.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: An
authors.affiliation: Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Jens C
authors.initials: JC
authors.lastname: Frisvad
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry / Q000145:classification* / Q000302:isolation & purification*; D004271:DNA, Fungal / Q000235:genetics; D054714:Echinocandins / Q000494:pharmacology*; D055666:Lipopeptides / Q000494:pharmacology*; D055442:Metabolome; D005810:Multigene Family; D010802:Phylogeny; D064210:Secondary Metabolism; D017422:Sequence Analysis, DNA; D013045:Species Specificity
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D054714:Echinocandins; D055666:Lipopeptides; C052098:mulundocandin