title: Does the use of statins improve outcomes in coronary artery bypass graft surgery?
abstract: Statins (3-hydroxy-3-methylglutaryl CoA reductase inhibitors) are one of the most frequently prescribed medications throughout the world with beneficial effects that extend beyond their lipid-lowering activity. It has been suggested that statins may offer a simple and cost-effective strategy to reduce some of the complications that occur in association with coronary artery bypass graft (CABG) surgery. Limited existing randomized trial evidence in the setting of cardiac surgery suggests that statins may reduce the incidence of postoperative atrial fibrillation. However, any effect of statins on other outcomes is less clear. The clinical significance of specific statin agent and dose, acute statin withdrawal and the potential benefits associated with statin reloading remain important yet currently unresolved issues. Despite limited high-quality evidence, class I recommendations have been made that all patients undergoing coronary artery bypass graft surgery should receive statin therapy unless contraindicated.
authors.affiliation: a Department of Anaesthesia and Perioperative Medicine , Alfred Hospital and Monash University , Melbourne , Victoria , Australia.
authors.forename: David R
authors.initials: DR
authors.lastname: McIlroy
authors.affiliation: a Department of Anaesthesia and Perioperative Medicine , Alfred Hospital and Monash University , Melbourne , Victoria , Australia.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Myles
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism / Q000601:surgery; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000145:classification / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects*; D011183:Postoperative Complications / Q000517:prevention & control*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: anesthesia; cardiovascular; evidence; outcome; surgery