title: Eosinophilic granulomatosis with polyangiitis demonstrating IgE-immune complexes and the possible involvement of IgE autoantibodies.
abstract: We herein report a case of female eosinophilic granulomatosis with polyangiitis (EGPA) in which polyethylene glycol (PEG) precipitation was used to evaluate the patient's levels IgE-immune complexes (IC). Her serum IgE (7,110 IU/mL) and IgE-IC (1,880 IU/mL) levels were observed with an IgE PEG precipitated index of 26.4%. We speculate that the circulating IgE-IC were formed by anti-neutrophil IgE autoantibodies. Therefore, the large amount of IgE autoantibodies in the patient's serum appears to have induced a constant allergic pathology. This pathology may have resulted in a marked infiltration of eosinophils into the tissues, as well as intensified the EGPA pathology.
authors.affiliation: Department of Otorhinolaryngology, Toho University Sakura Medical Center, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ota
authors.forename: Mutsunori
authors.initials: M
authors.lastname: Fujiwara
authors.forename: Yoji
authors.initials: Y
authors.lastname: Hirabayashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Kumasaka
authors.forename: Tamiko
authors.initials: T
authors.lastname: Takemura
authors.forename: Rumi
authors.initials: R
authors.lastname: Ota
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Suzuki
authors.forename: Shigeko
authors.initials: S
authors.lastname: Inokuma
mesh_terms: D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D000936:Antigen-Antibody Complex / Q000097:blood*; D001323:Autoantibodies / Q000097:blood; D004802:Eosinophilia / Q000097:blood*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; C026408:anti-IgE antibodies; D007073:Immunoglobulin E