title: Activity and mRNA Levels of Enzymes Involved in Hepatic Fatty Acid Synthesis in Rats Fed Naringenin.
abstract: We investigated the physiological activity of naringenin in affecting hepatic lipogenesis and serum and liver lipid levels in rats. Rats were fed diets containing 0, 1, or 2.5 g/kg naringenin for 15 d. Naringenin at a dietary level of 2.5 g/kg significantly decreased the activities and the mRNA levels of various lipogenic enzymes and sterol regulatory element binding protein-1c (SREBP-1c) mRNA level. The activities and the mRNA levels were also 9-22% and 12-38% lower, respectively, in rats fed a 1 g/kg naringenin diet than in the animals fed a naringenin-free diet, although the differences were not significant in many cases. Naringenin at 2.5 g/kg significantly lowered serum triacylglycerol, cholesterol, and phospholipid and hepatic triacylglycerol and cholesterol. This flavonoid at 1.0 g/kg also significantly lowered these parameters except for serum triacylglycerol. Naringenin levels in serum and liver dose-dependently increased, and hepatic concentrations reached levels that can affect various signaling pathways.
authors.affiliation: Nippon Shinyaku Co., Ltd. , 14 Nishinosho-Monguchi, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Hashimoto
authors.affiliation: Department of Food and Nutrition, Faculty of Human Life, Jumonji University , 2-1-28 Sugasawa, Niiza, Saitama 352-8510, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ide
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004798:Enzymes / Q000235:genetics* / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D044950:Flavanones / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D004798:Enzymes; D005227:Fatty Acids; D044950:Flavanones; D010743:Phospholipids; D012333:RNA, Messenger; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; D002784:Cholesterol; C005273:naringenin
keywords: hepatic lipogenesis; liver lipid levels; naringenin; rat; serum lipid levels