title: Association of four common SNPs in microRNA polymorphisms with the risk of hepatocellular carcinoma.
abstract: We conducted a case-control study to investigate genetic variants of miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs2292832 and miR-499 rs3746444 in the development of HCC in a Chinese population. This case-control study included 266 HCC patients and 266 control subjects between January 2012 and December 2013. Conditional logistical regression analysis indicated that TT genotype and T allele of miR-196a2 rs11614913 carried a 2.29-fold (95% CI = 1.30-4.05) and 1.60-fold (95% CI = 1.11-2.32) increased risk of HCC when compared with CC genotype, respectively. The subgroup analysis indicated that the effect of miR-196a2 rs11614913 polymorphism was influence by HBV infection. HBV infection subjects carrying the CT + TT genotype of miR-196a2 rs11614913 had an increased risk of HCC, and the OR (95% CI) was 2.89 (1.19-7.02). In conclusion, miR-196a2 rs11614913 polymorphism may contribute to identifying individuals, especially in HBV-infected subjects, who are at high risk for HCC.
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China.
authors.forename: Xinhong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of General Medicine, Baotou Tumor Hospital Baotou 014000, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China.
authors.forename: Zhongjun
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000821:virology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000821:virology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C542543:MIRN196 microRNA, human; D035683:MicroRNAs
keywords: MicroRNA; hepatocellular carcinoma; polymorphism