title: Robust silver-mediated imidazolo-dC base pairs in metal DNA: dinuclear silver bridges with exceptional stability in double helices with parallel and antiparallel strand orientation.
abstract: A new unprecedented metal-mediated base pair was designed that stabilizes reverse Watson-Crick DNA (parallel strand orientation, ps) as well as canonical Watson-Crick DNA (antiparallel strand orientation, aps). This base pair contains two imidazolo-dC units decorated with furan residues. Tm measurements and spectroscopic studies reveal that each silver-mediated furano-imidazolo-dC forms exceptionally stable duplexes with ps and aps chain orientation. This stability increase by a silver-mediated base pair is the highest reported so far for ps and aps DNA helices.
authors.affiliation: Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Heisenbergstraße 11, 48149 Münster, Germany.
authors.forename: Sunit Kumar
authors.initials: SK
authors.lastname: Jana
authors.affiliation: Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Heisenbergstraße 11, 48149 Münster, Germany and Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University, No. 1 Keyuan 4th Road, Gaopengdadao, Chengdu 610041, P. R. China.
authors.forename: Xiurong
authors.initials: X
authors.lastname: Guo
authors.affiliation: Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Heisenbergstraße 11, 48149 Münster, Germany.
authors.forename: Hui
authors.initials: H
authors.lastname: Mei
authors.affiliation: Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Heisenbergstraße 11, 48149 Münster, Germany and Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie neuer Materialien, Universität Osnabrück, Barbarastraße 7, 49069 Osnabrück, Germany. frank.seela@uni-osnabrueck.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Seela
mesh_terms: D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D012834:Silver / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D012834:Silver; D004247:DNA