title: Epstein-Barr virus latency: current and future perspectives.
abstract: EBV drives resting B cells to continuous proliferating latently infected cells. A restricted program of viral transcription contributes to latency and cell proliferation important for growth transformation. Recent interest in latency and transformation has provided new data about the roles of the EBV encoded latent proteins and non-coding RNAs. We broadly describe the transcription, epigenetic, signaling and super-enhancer functions of the latent nuclear antigens in regulating cellular transcription; the role of LMP2 in utilization of the autophagosome to control cell death, and the association between LMP1, the linear ubiquitin chain assembly complex and TRAF1 which are important for transformation. This review explores recent discoveries with new insights into therapeutic avenues for EBV related malignancies.
authors.affiliation: Department of Gene Vectors, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany. Electronic address: kempkes@helmholtz-muenchen.de.
authors.forename: Bettina
authors.initials: B
authors.lastname: Kempkes
authors.affiliation: Department of Microbiology and the Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: erle@upenn.edu.
authors.forename: Erle S
authors.initials: ES
authors.lastname: Robertson
mesh_terms: D063646:Carcinogenesis; D005786:Gene Expression Regulation; D004854:Herpesvirus 4, Human / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D017735:Virus Latency