title: Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy.
abstract: Background. Periodontal disease is a chronic inflammatory condition affecting the supporting structures of the dentition. Periodontal destruction is an outcome of the imbalance between matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases (TIMPs). We wanted to prove the hypothesis that salivary TIPM-1 level will vary in different people. A decrease in TIMP-1 level could make them more susceptible to periodontitis whereas a normal level could prevent increased tissue destruction thereby inhibiting the progression from gingivitis to periodontitis. This could probably pave the way for TIPM-1 to be a specific salivary biomarker and serve as a useful diagnostic and therapeutic tool in periodontitis. Methods. Whole unstimulated saliva of 2 ml was collected from twenty-five periodontally healthy and twenty-seven systemically healthy subjects with periodontitis. Clinical parameters recorded at baseline and reevaluated after four weeks in subjects with periodontitis following nonsurgical periodontal therapy were gingival index (GI), oral hygiene index-Simplified (OHI-S), probing pocket depth, and clinical attachment level (CAL). Salivary TIMP-1 levels in both were analyzed using a commercially available ELISA kit.
authors.affiliation: Department of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
authors.forename: Angel
authors.initials: A
authors.lastname: Fenol
authors.affiliation: Department of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
authors.forename: Maya Rajan
authors.initials: MR
authors.lastname: Peter
authors.affiliation: Department of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
authors.forename: Jayachandran
authors.initials: J
authors.lastname: Perayil
authors.affiliation: Department of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Vyloppillil
authors.affiliation: Department of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Bhaskar