title: 3'-hydroxy-ε,ε-caroten-3-one inhibits the differentiation of 3T3-L1 cells to adipocytes.
abstract: An oxidative metabolite of lutein, 3'-hydroxy-ε,ε-caroten-3-one, inhibited the differentiation of 3T3-L1 cells to adipocytes and the subsequent triacylglycerol production, but lutein did not. The α,β-unsaturated carbonyl structure of 3'-hydroxy-ε,ε-caroten-3-one was considered to participate in the inhibitory effect, suggesting that this lutein metabolite has the potential to prevent metabolic syndrome.
authors.affiliation: a Food Resource Division , National Food Research Institute, National Agriculture and Food Research Organization , Tsukuba , Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kotake-Nara
authors.affiliation: a Food Resource Division , National Food Research Institute, National Agriculture and Food Research Organization , Tsukuba , Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Hase
authors.affiliation: a Food Resource Division , National Food Research Institute, National Agriculture and Food Research Organization , Tsukuba , Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: a Food Resource Division , National Food Research Institute, National Agriculture and Food Research Organization , Tsukuba , Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nagao
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D014975:Lutein / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice
chemical_list: C552883:3'-hydroxy-epsilon,epsilon-caroten-3-one; D014975:Lutein
keywords: 3T3-L1; adipocyte; carotenoid; lutein; metabolite