title: Stimuli-responsive weak polyelectrolyte multilayer films: A thin film platform for self triggered multi-drug delivery.
abstract: Polyelectrolyte multilayer (PEM) thin film composed of weak polyelectrolytes was designed by layer-by-layer (LbL) assembly of poly(allylamine hydrochloride) (PAH) and poly(methacrylic acid) (PMA) for multi-drug delivery applications. Environmental stimuli such as pH and ionic strength showed significant influence in changing the film morphology from pore-free smooth structure to porous structure and favored triggered release of loaded molecules. The film was successfully loaded with bovine serum albumin (BSA) and ciprofloxacin hydrochloride (CH) by modulating the porous polymeric network of the film. Release studies showed that the amount of release could be easily controlled by changing the environmental conditions such as pH and ionic strength. Sustained release of loaded molecules was observed up to 8h. The fabricated films were found to be biocompatible with epithelial cells during in-vitro cell culture studies. PEM film reported here not only has the potential to be used as self-responding thin film platform for transdermal drug delivery, but also has the potential for further development in antimicrobial or anti-inflammatory coatings on implants and drug-releasing coatings for stents.
authors.affiliation: SRM Research Institute, SRM University, Kattankulathur, Chennai 603203, India. Electronic address: rsanandhakumar@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Anandhakumar
authors.affiliation: SRM Research Institute, SRM University, Kattankulathur, Chennai 603203, India.
authors.forename: P
authors.initials: P
authors.lastname: Gokul
authors.affiliation: Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India.
authors.forename: A M
authors.initials: AM
authors.lastname: Raichur
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D002939:Ciprofloxacin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004573:Electrolytes / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000633:toxicity; D012710:Serum Albumin, Bovine / Q000737:chemistry; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D004573:Electrolytes; D011108:Polymers; D012710:Serum Albumin, Bovine; D002939:Ciprofloxacin
keywords: Ciprofloxacin hydrochloride; Dual drug delivery; Multilayer films; Stimuli-responsive