title: Increased red cell distribution width is associated with poor stem cell mobilization in patients with advanced chronic heart failure.
abstract: Parameters associated with poor CD34(+) stem cell mobilization in advanced chronic heart failure (CHF) patients were investigated. Forty-four CHF patients underwent bone marrow stimulation with granulocyte colony stimulating factor. Poor cell mobilization presents in 32% of patients. Poor and good mobilizers did not differ significantly regarding age, gender, left ventricular ejection fraction, kidney or liver function and exercise capacity. Significant differences were found regarding NT-proBNP levels and red cell distribution width (RDW). Increased RDW was the only independent predictor of poor CD34(+) stem cell mobilization on multivariable analysis and may serve as a biomarker of poor stem cell mobilization in CHF patients.
authors.affiliation: a Department of Cardiology , Advanced Heart Failure and Transplantation Center, University Medical Center Ljubljana , Ljubljana , Slovenia .
authors.forename: Gregor
authors.initials: G
authors.lastname: Poglajen
authors.affiliation: b Department of Hematology , University Medical Center Ljubljana , Ljubljana , Slovenia , and.
authors.forename: Matjaž
authors.initials: M
authors.lastname: Sever
authors.affiliation: b Department of Hematology , University Medical Center Ljubljana , Ljubljana , Slovenia , and.
authors.forename: Peter
authors.initials: P
authors.lastname: Černelč
authors.affiliation: c Division of Cardiovascular Medicine , Stanford University School of Medicine , Palo Alto , CA , USA.
authors.forename: Francois
authors.initials: F
authors.lastname: Haddad
authors.affiliation: a Department of Cardiology , Advanced Heart Failure and Transplantation Center, University Medical Center Ljubljana , Ljubljana , Slovenia .
authors.forename: Bojan
authors.initials: B
authors.lastname: Vrtovec
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D004909:Erythrocyte Indices; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D006333:Heart Failure / Q000097:blood* / Q000628:therapy; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods* / Q000706:statistics & numerical data; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D018952:Antigens, CD34; D015415:Biomarkers; D016179:Granulocyte Colony-Stimulating Factor
keywords: Bone marrow; heart failure; stem cell therapy