title: Fertility in childhood cancer survivors following cranial irradiation for primary central nervous system and skull base tumors.
abstract: Recent advances in pediatric cancer treatment have improved disease control and survival outcomes for childhood cancers survivors, including those treated for primary central nervous system and skull base malignancies. Future research in this population will focus on identifying risk factors for infertility, novel screening techniques and recommendations, and quality-of-life outcomes improvement. The purpose of this review is to define the infertility complications observed in pediatric cancer survivors who receive cranial irradiation for central nervous system and skull base malignancies.
authors.affiliation: Department of Radiation Oncology, University of Florida, Jacksonville, FL, United States.
authors.forename: Tamara Z
authors.initials: TZ
authors.lastname: Vern-Gross
authors.affiliation: Department of Radiation Oncology, University of Florida, Jacksonville, FL, United States.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Bradley
authors.affiliation: Department of Radiation Oncology, University of Florida, Jacksonville, FL, United States.
authors.forename: Ronny L
authors.initials: RL
authors.lastname: Rotondo
authors.affiliation: Department of Radiation Oncology, University of Florida, Jacksonville, FL, United States. Electronic address: dindelicato@floridaproton.org.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Indelicato
mesh_terms: D016543:Central Nervous System Neoplasms / Q000453:epidemiology / Q000532:radiotherapy*; D002648:Child; D016371:Cranial Irradiation / Q000009:adverse effects*; D005298:Fertility / Q000528:radiation effects*; D006062:Gonadotropins / Q000502:physiology; D006066:Gonads / Q000528:radiation effects; D006801:Humans; D007246:Infertility / Q000453:epidemiology / Q000209:etiology; D018570:Risk Assessment / Q000379:methods; D019292:Skull Base Neoplasms / Q000453:epidemiology / Q000532:radiotherapy*; D017741:Survivors
chemical_list: D006062:Gonadotropins
keywords: Fertility; Pediatric; Radiation therapy