title: Evaluation of the Mean Platelet Volume and Red Cell Distribution Width in FMF: Are They Related to Subclinical Inflammation or Not?
abstract: In this paper we want to demonstrate whether higher than normal levels of RDW, and lower than normal levels of MPV can be used as indicators of subclinical inflammation and tools for treatment decision in FMF or not. The participants in this study included 89 patients with FMF during attack-free periods and 30 healthy controls. The RDW and platelet counts were significantly higher, while the MPV was significantly lower in the patients with FMF group than healthy control group (P < 0.001; P = 0.005; P < 0.001, resp.). In the attack-free FMF group, a negative correlation was found between the MPV and RDW values (P < 0.001, r = -0.40). The positive correlation was found between the RDW and ESR (r = 0.23, P = 0.028). And the negative correlation was found between the MPV and CRP (r = -0.216, P = 0.042). Consequently, our results suggest that low MPV and high RDW levels may provide additional information about subclinical inflammation in FMF patients. But other strong predisposing factors affecting subclinical inflammation in FMF should be considered. Further studies with large numbers of patients are needed. Treatment of FMF should include not only prevention of acute attacks but also decreasing of the subclinical inflammation.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey.
authors.forename: Gozde
authors.initials: G
authors.lastname: Yildirim Cetin
authors.affiliation: Division of Hematology, Department of Pediatrics, School of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gul
authors.affiliation: Department of Internal Medicine, School of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Kesici-Metin
authors.affiliation: Department of Internal Medicine, School of Medicine, Sutcu Imam University, 46050 Kahramanmaras, Turkey.
authors.forename: İrem
authors.initials: İ
authors.lastname: Gokalp
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, School of Medicine, Ondokuz Mayis University, 55000 Samsun, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sayarlıoglu