title: Ranolazine in Cardiac Arrhythmia.
abstract: Ranolazine utilization in the management of refractory angina has been established by multiple randomized clinical studies. However, there is growing evidence showing an evolving role in the field of cardiac arrhythmias. Multiple experimental and clinical studies have evaluated the role of ranolazine in prevention and management of atrial fibrillation, with ongoing studies on its role in ventricular arrhythmias. In this review, we will discuss the pharmacological, experimental, and clinical evidence behind ranolazine use in the management of various cardiac arrhythmias.
authors.affiliation: Department of Medicine, Seton Hall University School of Health and Medical Sciences, Trinitas Regional Medical Center, Elizabeth, New Jersey.
authors.forename: Marwan
authors.initials: M
authors.lastname: Saad
authors.affiliation: Department of Medicine, University of Florida, Gainesville, Florida.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Mahmoud
authors.affiliation: Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida.
authors.forename: Islam Y
authors.identifier: http://orcid.org/0000-0001-9853-7591
authors.initials: IY
authors.lastname: Elgendy
authors.affiliation: Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida.
authors.forename: C
authors.initials: C
authors.lastname: Richard Conti
mesh_terms: D000200:Action Potentials; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D000069458:Ranolazine / Q000009:adverse effects / Q000627:therapeutic use*; D026941:Sodium Channel Blockers / Q000009:adverse effects / Q000627:therapeutic use*; D015222:Sodium Channels / Q000187:drug effects* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D000069458:Ranolazine