title: Flavonoids from Pronephrium megacuspe.
abstract: A chemical investigation of the whole plant of Pronephrium megacuspe (Bak.) Holtt. led to the isolation of four flavonoids, pronephrones A-D (1-4), which were firstly reported. The chemical structures of four compounds were established using spectroscopic methods. These isolates were further evaluated for cytotoxicity to ovarian cells of Spodoptera litura Fabricius.
authors.affiliation: a College of Chemistry and Chemical Engineering , Zhongkai University of Agriculture and Engineering , Guangzhou 510225 , China.
authors.forename: Su-Qing
authors.initials: SQ
authors.lastname: Huang
authors.affiliation: b Key Laboratory of Natural Pesticides and Chemical Biology, Ministry of Education , South China Agricultural University , Guangzhou 510630 , China.|c State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources , South China Agricultural University , Guangzhou 510630 , China.
authors.forename: Yong-Qing
authors.initials: YQ
authors.lastname: Tian
authors.affiliation: d Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 510650 , China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Wei
authors.affiliation: b Key Laboratory of Natural Pesticides and Chemical Biology, Ministry of Education , South China Agricultural University , Guangzhou 510630 , China.|c State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources , South China Agricultural University , Guangzhou 510630 , China.
authors.forename: Han-Hong
authors.initials: HH
authors.lastname: Xu
mesh_terms: D000818:Animals; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006793:Houseflies; D007306:Insecticides / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010053:Ovary / Q000166:cytology / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D018411:Spodoptera / Q000166:cytology / Q000187:drug effects
chemical_list: D003603:Cytotoxins; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007306:Insecticides
keywords: Pronephrium megacuspe; Thelypteridaceae; cytotoxicity; pronephrones A–D