title: Restoring Ikaros's wings to solve a leukemia maze.
abstract: In this issue of Blood, Song et al show that tumor suppressor activity of Ikaros is achieved though repression of cell cycle and phosphatidylinositol-3 (PI3) kinase pathway genes and can be reactivated through pharmacologic inhibition of casein kinase 2 (CK2) to eradicate disease in high-risk B-cell acute lymphoblastic leukemia (B-ALL).
authors.affiliation: INSTITUT GUSTAVE ROUSSY.
authors.forename: Camille
authors.identifier: http://orcid.org/0000-0003-0550-4921
authors.initials: C
authors.lastname: Lobry
mesh_terms: D000818:Animals; D047390:Casein Kinase II / Q000037:antagonists & inhibitors*; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D051740:Ikaros Transcription Factor / Q000378:metabolism*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000473:pathology*
chemical_list: D051740:Ikaros Transcription Factor; D047390:Casein Kinase II