title: Splicing and Dicing MYC-Mediated Synthetic Lethality.
abstract: In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.
authors.affiliation: Abramson Family Cancer Research Institute, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Zachary E
authors.initials: ZE
authors.lastname: Stine
authors.affiliation: Abramson Family Cancer Research Institute, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: dangvchi@exchange.upenn.edu.
authors.forename: Chi V
authors.initials: CV
authors.lastname: Dang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D017381:Spliceosomes / Q000187:drug effects* / Q000378:metabolism*