title: Induction of substantial myocardial regeneration by an active fraction of the Chinese herb Rosa laevigata Michx.
abstract: BACKGROUND
  The replacement of lost cardiac tissues by regenerated myocardium would be a therapeutic ideal for myocardial infarction. The objective of this study was therefore to evaluate the ability of an active fraction that was isolated from Rosa laevigata Michx in therapeutic cardiomyogenesis in a myocardial infarction rat model.
  
  
  METHODS
  The myocardial infarction animal model was induced by the permanent ligation of the left anterior descending coronary artery in rats. The active fraction, which improves the survival rate and prevents ischemic reperfusion damage, was used to test the therapeutic effect of this fraction on myocardial infarction.
  
  
  RESULTS
  The oral administration of the active fraction for 4 weeks could progressively restore the decreased cardiac function due to myocardial infarction. The significantly improved cardiac function was probably attributed to the active fraction-induced myocardial regeneration, which replaced the lost cardiac tissues in the myocardial infarction animals.
  
  
  CONCLUSIONS
  The property of this active fraction appears to be entirely novel and may provide a potential therapeutic alternative for myocardial infarction.
authors.affiliation: Department of Cardiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. sgyyjxb@163.com.
authors.forename: Huiyan
authors.initials: H
authors.lastname: Qu
authors.affiliation: Department of Cardiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. fengzhou0501@163.com.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Laboratory of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China. orange__fly@sina.com.
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Li
authors.affiliation: Queen Mary University of London, London, UK. 252285535@qq.com.
authors.forename: Censing
authors.initials: C
authors.lastname: Li
authors.affiliation: Laboratory of Innovative Medicine, Hong Kong, Hong Kong. 13661876850@163.com.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Tang
authors.affiliation: Laboratory of Innovative Medicine, Hong Kong, Hong Kong. 18501611971@wo.com.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Emergency Department, Tianshan Chinese Medicine Hospital, Changning District, Shanghai, China. 13916896821@163.com.
authors.forename: Dianbin
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Cardiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. 176537006@qq.com.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Laboratory of Innovative Medicine, Hong Kong, Hong Kong. li.ming@labinnovativemedicine.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Cardiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. zhouhuam@hotmail.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006321:Heart / Q000502:physiology*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D032383:Myocytes, Cardiac / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology*; D027826:Rosa / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal