title: Use of Vandetanib in Metastatic Medullary Carcinoma of Thyroid in a Pediatric Patient With Multiple Endocrine Neoplasia 2B.
abstract: We describe a child with advanced, metastatic, inoperable medullary carcinoma of thyroid associated with multiple endocrine neoplasia 2B and rearranged during transfection mutation with a positive response to vandetanib treatment. He responded well with a fall in calcitonin levels and a reduction in size of the thyroid malignancy, lymph nodes, and pulmonary metastases. He has been on vandetanib for 4 years with good clinical and biochemical response. Vandetanib has a role in the treatment of patients including children with inoperable locally advanced and metastatic medullary carcinoma of thyroid. More information is needed on its use in children and long-term outcome.
authors.affiliation: Departments of *Paediatric Endocrinology †Paediatric Haemato-Oncology ‡ENT, Royal Hospital for Sick Children §Clinical Genetics, Southern General Hospital ∥Paediatric Dentistry, University of Glasgow Dental School ¶Department of Clinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK.
authors.forename: Vidya K
authors.initials: VK
authors.lastname: Narayanan
authors.forename: Milind
authors.initials: M
authors.lastname: Ronghe
authors.forename: Fiona B
authors.initials: FB
authors.lastname: MacGregor
authors.forename: Nicola
authors.initials: N
authors.lastname: Bradshaw
authors.forename: Rosemarie
authors.initials: R
authors.lastname: Davidson
authors.forename: Richard
authors.initials: R
authors.lastname: Welbury
authors.forename: Nicholas
authors.initials: N
authors.lastname: Reed
authors.forename: Mohamad G
authors.initials: MG
authors.lastname: Shaikh
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy* / Q000235:genetics; D002648:Child; D006801:Humans; D008297:Male; D018813:Multiple Endocrine Neoplasia Type 2a / Q000150:complications; D010880:Piperidines / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D010880:Piperidines; D011799:Quinazolines; C452423:vandetanib