title: Gender in the allocation of organs in kidney transplants: meta-analysis.
abstract: OBJECTIVE To analyze whether gender influence survival results of kidney transplant grafts and patients.METHODS Systematic review with meta-analysis of cohort studies available on Medline (PubMed), LILACS, CENTRAL, and Embase databases, including manual searching and in the grey literature. The selection of studies and the collection of data were conducted twice by independent reviewers, and disagreements were settled by a third reviewer. Graft and patient survival rates were evaluated as effectiveness measurements. Meta-analysis was conducted with the Review Manager® 5.2 software, through the application of a random effects model. Recipient, donor, and donor-recipient gender comparisons were evaluated.
  
  
  RESULTS
  Twenty-nine studies involving 765,753 patients were included. Regarding graft survival, those from male donors were observed to have longer survival rates as compared to the ones from female donors, only regarding a 10-year follow-up period. Comparison between recipient genders was not found to have significant differences on any evaluated follow-up periods. In the evaluation between donor-recipient genders, male donor-male recipient transplants were favored in a statistically significant way. No statistically significant differences were observed in regards to patient survival for gender comparisons in all follow-up periods evaluated.CONCLUSIONS The quantitative analysis of the studies suggests that donor or recipient genders, when evaluated isolatedly, do not influence patient or graft survival rates. However, the combination between donor-recipient genders may be a determining factor for graft survival.
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR.
authors.forename: Erika Vieira Almeida e
authors.initials: EV
authors.lastname: Santiago
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR.
authors.forename: Micheline Rosa
authors.initials: MR
authors.lastname: Silveira
authors.affiliation: Departamento de Odontologia, Instituto de Ciências Biológicas e da Saúde. Pontifícia, Universidade Católica de Minas Gerais, Belo Horizonte, MG, BR.
authors.forename: Vânia Eloisa de
authors.initials: VE
authors.lastname: Araújo
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR.
authors.forename: Katia de Paula
authors.initials: Kde P
authors.lastname: Farah
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR.
authors.forename: Francisco de Assis
authors.initials: Fde A
authors.lastname: Acurcio
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR.
authors.forename: Maria das Graças Braga
authors.initials: Md
authors.lastname: Ceccato
mesh_terms: D001938:Brazil; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000706:statistics & numerical data*; D008297:Male; D012737:Sex Factors; D013997:Time Factors