title: Bioinspired Zwitterionic Surface Coatings with Robust Photostability and Fouling Resistance.
abstract: Great care has been paid to the biointerface between a bulk material and the biological environment, which plays a key role in the optimized performance of medical devices. In this work, we report a new superhydrophilic adsorbate, called L-cysteine betaine (Cys-b), having branched zwitterionic groups that give rise to surfaces and nanoparticles with enhanced chemical stability, biofouling resistance, and inertness to environmental changes. Cys-b was synthesized from the amphoteric sulfur-containing amino acid, L-cysteine (Cys), by quaternization of its amino group. Gold surfaces modified with Cys-b exhibited prominent repellence against the nonspecific adsorption of proteins, bacteria, and fibroblast cells. In addition, Cys-b existed in zwitterionic form over a wide pH range (i.e., pH 3.4 to 10.8), and showed excellent suppression in photoinduced oxidation on gold substrates. Furthermore, the modification of hollow Ag@Au nanoshells with Cys-b gave rise to nanoparticles with excellent colloidal stability and resistance to coordinative interaction with Cu(2+). Taken together, the unique features of Cys-b offer a new nanoscale coating for use in a wide spectrum of applications.
authors.forename: Chun-Jen
authors.initials: CJ
authors.lastname: Huang
authors.forename: Sz-Hau
authors.initials: SH
authors.lastname: Chu
authors.forename: Lin-Chuan
authors.initials: LC
authors.lastname: Wang
authors.affiliation: Department of Chemistry and the Texas Center for Superconductivity, University of Houston , Houston, Texas 77204-5003 United States.
authors.forename: Chien-Hung
authors.initials: CH
authors.lastname: Li
authors.affiliation: Department of Chemistry and the Texas Center for Superconductivity, University of Houston , Houston, Texas 77204-5003 United States.
authors.forename: T Randall
authors.initials: TR
authors.lastname: Lee
mesh_terms: D000327:Adsorption / Q000187:drug effects*; D000596:Amino Acids / Q000737:chemistry; D001622:Betaine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D057219:Biofouling; D003545:Cysteine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004864:Equipment and Supplies; D006046:Gold / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D011108:Polymers / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000187:drug effects; D013499:Surface Properties / Q000187:drug effects
chemical_list: D000596:Amino Acids; D011108:Polymers; D012710:Serum Albumin, Bovine; D001622:Betaine; D006046:Gold; D003545:Cysteine
keywords: antifouling coatings; biocompatible; bioinspired materials; nanomaterials; zwitterionic materials