title: Can Free Water Transport Be Used as a Clinical Parameter for Peritoneal Fibrosis in Long-Term PD Patients?
abstract: Sodium sieving in peritoneal dialysis (PD) occurs in a situation with high osmotically-driven ultrafiltration rates. This dilutional phenomenon is caused by free water transport through the water channel aquaporin-1. It has recently been described that encapsulating peritoneal fibrosis is associated with impaired free water transport, despite normal expression of aquaporin-1. In this review, it will be argued that free water transport can be used for assessment of fibrotic peritoneal alterations, due to the water-binding capacity of collagen. Finally, the consequences for clinical practice will be discussed.
authors.affiliation: Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands r.t.krediet@amc.uva.nl.
authors.forename: Raymond T
authors.initials: RT
authors.lastname: Krediet
authors.affiliation: Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: Deirisa
authors.initials: D
authors.lastname: Lopes Barreto
authors.affiliation: Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands Dianet Foundation, Amsterdam-Utrecht, The Netherlands.
authors.forename: Dirk G
authors.initials: DG
authors.lastname: Struijk
mesh_terms: D001692:Biological Transport / Q000502:physiology*; D006801:Humans; D010530:Peritoneal Dialysis; D056627:Peritoneal Fibrosis / Q000378:metabolism*; D010537:Peritoneum / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water; D012964:Sodium
keywords: Free water transport; encapsulating peritoneal sclerosis; peritoneal dialysis; peritoneal fibrosis; small pore fluid transport; sodium