title: Environments of hematopoiesis and B-lymphopoiesis in foetal liver.
abstract: In human and murine embryonic development, haematopoiesis and B-lymphopoiesis show stepwise differentiation from pluripotent haematopoietic stem cells and multipotent progenitors, over lineage-restricted lymphoid and myeloid progenitors to B-lineage committed precursors and finally differentiated pro/preB cells. This wave of differentiation is spatially and temporally organised by the surrounding, mostly non-haematopoietic cell niches. We review here recent developments and our current contributions on the research on blood cell development.
authors.affiliation: Max Planck Fellow Research Group on "Lymphocyte Development", Max Planck Institute for Infection Biology, Berlin, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Kajikhina
authors.affiliation: Max Planck Fellow Research Group on "Lymphocyte Development", Max Planck Institute for Infection Biology, Berlin, Germany; and Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Motokazu
authors.initials: M
authors.lastname: Tsuneto
authors.affiliation: Max Planck Fellow Research Group on "Lymphocyte Development", Max Planck Institute for Infection Biology, Berlin, Germany. melchers@mpiib-berlin.mpg.de.
authors.forename: Fritz
authors.initials: F
authors.lastname: Melchers
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D019070:Cell Lineage; D002465:Cell Movement; D006411:Hematopoiesis, Extramedullary; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000196:embryology*; D038041:Lymphopoiesis; D039902:Multipotent Stem Cells / Q000502:physiology*; D054448:Precursor Cells, B-Lymphoid / Q000502:physiology*; D015398:Signal Transduction; D055153:Stem Cell Niche