title: Serum Ferritin Is Associated with Metabolic Syndrome and Red Meat Consumption.
abstract: OBJECTIVE
  Hyperferritinemia has been related with a wide spectrum of pathologies, including diabetes, cardiovascular disease, neurodegenerative disorders, and metabolic syndrome. The aim of this study was to investigate the association between hyperferritinemia and iron consumption.
  
  
  RESULTS
  Serum ferritin concentration was evaluated in 66 presumed healthy men, along with other clinical and biochemical markers of chronic diseases. A three-day food questionnaire was applied for nutrition information. Hyperferritinemia was a condition found in 13.4% of the volunteers analyzed. Significant correlations were found between serum ferritin concentration and metabolic syndrome parameters (HDL cholesterol, triglycerides, and fasting glucose) as well as an increase of the serum ferritin mean value with the number of risk factors of metabolic syndrome. Also, oxidative stress markers (carbonyl groups, AOPP, and glycated hemoglobin), hepatic damage markers (GGT, SGOT), and parameters related to insulin resistance (HOMA, blood insulin, and blood glucose) correlate significantly with serum ferritin. Volunteers had an excessive iron intake, principally by bread consumption. Analyses of food intake showed that red meat consumption correlates significantly with serum ferritin.
  
  
  CONCLUSIONS
  Red meat consumption, metabolic syndrome, and chronic disease markers are associated with hyperferritinemia in a population of Chilean men.
authors.affiliation: Programa de Investigación de Excelencia Interdisciplinaria en Envejecimiento Saludable (PIEI-ES), Universidad de Talca, 3460000 Talca, Chile ; Centro de Nutrición Molecular y Enfermedades Crónicas, Pontificia Universidad Católica de Chile, Casilla 114-D, 8331150 Santiago, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Avila
authors.affiliation: Centro de Nutrición Molecular y Enfermedades Crónicas, Pontificia Universidad Católica de Chile, Casilla 114-D, 8331150 Santiago, Chile.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Echeverría
authors.affiliation: Centro de Nutrición Molecular y Enfermedades Crónicas, Pontificia Universidad Católica de Chile, Casilla 114-D, 8331150 Santiago, Chile.
authors.forename: Druso
authors.initials: D
authors.lastname: Pérez
authors.affiliation: Centro de Nutrición Molecular y Enfermedades Crónicas, Pontificia Universidad Católica de Chile, Casilla 114-D, 8331150 Santiago, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Martinez
authors.affiliation: Centro de Nutrición Molecular y Enfermedades Crónicas, Pontificia Universidad Católica de Chile, Casilla 114-D, 8331150 Santiago, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: Strobel
authors.affiliation: Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, 8330024 Santiago, Chile.
authors.forename: Oscar
authors.initials: O
authors.lastname: Castillo
authors.affiliation: Departamento de Salud Pública, Facultad de Medicina, Pontificia Universidad Católica de Chile, 8330024 Santiago, Chile.
authors.forename: Luis
authors.initials: L
authors.lastname: Villaroel
authors.affiliation: Laboratorio de Hemostasia, Facultad de Medicina, Pontificia Universidad Católica de Chile, 8330024 Santiago, Chile.
authors.forename: Diego
authors.initials: D
authors.lastname: Mezzano
authors.affiliation: Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, 8330024 Santiago, Chile.
authors.forename: Jaime
authors.initials: J
authors.lastname: Rozowski
authors.affiliation: Centro de Nutrición Molecular y Enfermedades Crónicas, Pontificia Universidad Católica de Chile, Casilla 114-D, 8331150 Santiago, Chile.
authors.forename: Inés
authors.initials: I
authors.lastname: Urquiaga
authors.affiliation: Centro de Nutrición Molecular y Enfermedades Crónicas, Pontificia Universidad Católica de Chile, Casilla 114-D, 8331150 Santiago, Chile.
authors.forename: Federico
authors.initials: F
authors.lastname: Leighton
mesh_terms: D000328:Adult; D005293:Ferritins / Q000097:blood*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology*; D000069466:Red Meat / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D005293:Ferritins