title: [Clinical Investigation of the Effects of Filgrastim BS1 on Neutropenia Following Oral Cancer Chemotherapy (TPF Therapy)].
abstract: The time for the neutrophil count to recover after subcutaneous injection of filgrastim BS1 or lenograstim was studied in patients suffering from neutropenia following preoperative combined chemotherapy using docetaxel, nedaplatin, or cisplatin (in divided doses for 5 days)and 5-fluorouracil for oral cancer. 1. There was no significant difference in the minimum leukocyte and neutrophil counts after chemotherapy. 2. There was no significant difference in the maximum leukocyte and neutrophil counts after chemotherapy. 3. Time for leukocytes to recover from their minimum count(>4,000/mm3)or for neutrophils to recover from their minimum count(>2,000/mm3)and the number of days on which treatment was administered tended to be shorter in the filgrastim BS1 group. Thus, it was concluded that filgrastim BS1 is just as effective as other prior G-CSF agents in treating patients suffering from neutropenia following chemotherapy(TPF therapy).
authors.affiliation: Dept. of Dentistry and Oral Surgery, National Hospital Organization Tochigi Medical Center.
authors.forename: Kimio
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamada
authors.forename: Shusuke
authors.initials: S
authors.lastname: Tamate
authors.forename: Konomi
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Mitomo
authors.forename: Seiichi
authors.initials: S
authors.lastname: Nakayama
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005260:Female; D000069585:Filgrastim; D005472:Fluorouracil / Q000008:administration & dosage; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D009503:Neutropenia / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D043823:Taxoids; D016179:Granulocyte Colony-Stimulating Factor; D000077143:Docetaxel; D000069585:Filgrastim; D002945:Cisplatin; D005472:Fluorouracil