title: LPO-Antioxidant Defense System in Newborns and Women Drinking Small Amounts of Alcohol During Pregnancy.
abstract: We studied the effects of consumption of low-alcohol drinks (no more than 2 doses) during pregnancy on the state of LPO-antioxidant defense system and glutathione level in the blood serum and erythrocytes of pregnant women and newborns. It was found that even single alcohol intake was followed by the development of oxidative stress in women and newborns. In pregnant women, the decrease in reduced glutathione content and glutathione reductase activity associated with increased level of oxidized glutathione and glutathione transferase activity were typical changes. In newborns, the decrease in reduced glutathione concentration was accompanied by a decrease in glutathione reductase, glutathione transferase, and glutathione peroxidase activities. It should be emphasized that even small alcohol doses produce delayed negative effects on metabolism of the mother and newborns.
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia. iphr@sbamstr.irk.ru.
authors.forename: L I
authors.initials: LI
authors.lastname: Kolesnikova
authors.affiliation: Irkutsk State Medical Academy of Postgraduate Education, Irkutsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Protopopova
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
authors.affiliation: Irkutsk State Medical University of the Ministry of Health of the Russian Federation, Irkutsk, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Maryanyan
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: B Ya
authors.initials: BY
authors.lastname: Vlasov
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Natyaganova
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000378:metabolism; D005978:Glutathione / Q000037:antagonists & inhibitors / Q000097:blood; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors / Q000097:blood; D005980:Glutathione Reductase / Q000037:antagonists & inhibitors / Q000097:blood; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D015227:Lipid Peroxidation / Q000187:drug effects*; D018384:Oxidative Stress; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D000431:Ethanol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione
keywords: alcohol drinks; glutathione; newborns; pregnant women; state of system of lipid peroxidation–antioxidant defense