title: Successful Treatment of Extra-Renal Noncerebral Rhabdoid Tumors with VIDE.
abstract: Extra-renal noncerebral rhabdoid tumors (ERRTs) are highly aggressive and often lethal. An optimal chemotherapy regimen for ERRT remains undetermined. We report on three pediatric patients successfully treated with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE). Two of our patients who had metastatic or refractory disease have survived more than 2 years, one disease free without myeloablative megatherapy. The treatment with high-dose alkylator therapy is reported to have a beneficial effect on survival. A VIDE regimen containing high-dose ifosfamide is feasible and appears to prolong the survival of patients with ERRT. This regimen may be a promising option for ERRT treatment without myeloablative megatherapy.
authors.affiliation: Division of Pediatric Oncology, National Cancer Center Hospital East.
authors.forename: Naoko
authors.initials: N
authors.lastname: Yasui
authors.affiliation: Division of Pathology and Clinical Laboratories, National Cancer Center Hospital.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Division of Musculoskeletal Oncology, National Cancer Center Hospital.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Kobayashi
authors.affiliation: Division of Musculoskeletal Oncology, National Cancer Center Hospital.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Nakatani
authors.affiliation: Division of Pediatric Oncology, National Cancer Center Hospital East.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawamoto
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D018335:Rhabdoid Tumor / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D007069:Ifosfamide
keywords: VIDE; chemotherapy; malignant rhabdoid tumor