title: Salicylic acid-based pH-sensitive hydrogels as potential oral insulin delivery systems.
abstract: Salicylic acid (SA)-based physically crosslinked pH-sensitive hydrogels were developed for oral insulin delivery using various ratios of salicylate-based poly(anhydride-ester) and poly(acrylic acid) (PAA). Pore size, swelling behavior, insulin loading, insulin and SA release rates of the gels were varied by changing PAA concentration. About 50% of insulin was incorporated within all of the hydrogels, with about 4-8% of insulin released in acidic conditions (pH 1.2) over 2 h. In pH simulating the intestine (pH 6.8), 90% of the insulin and 70% of SA were released within 24 h from the hydrogel system. These results suggest that hydrogels enable pH-dependent protein delivery and can be used for oral insulin and SA delivery to benefit diabetes patients.
authors.affiliation: a Department of Chemistry and Chemical Biology , Rutgers University , Piscataway , NJ , USA.
authors.forename: Bahar
authors.initials: B
authors.lastname: Demirdirek
authors.affiliation: a Department of Chemistry and Chemical Biology , Rutgers University , Piscataway , NJ , USA.
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Uhrich
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000284:Administration, Oral; D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry; D003920:Diabetes Mellitus / Q000188:drug therapy; D004337:Drug Carriers / Q000737:chemistry; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D051379:Mice; D041681:NIH 3T3 Cells; D049388:Polyanhydrides / Q000737:chemistry; D020156:Salicylic Acid / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000180:Acrylic Resins; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D004338:Drug Combinations; D020100:Hydrogels; D007004:Hypoglycemic Agents; D007328:Insulin; D049388:Polyanhydrides; C006903:carbopol 940; D020156:Salicylic Acid
keywords: Biodegradable polymers; oral administration; oral drug delivery; pH-sensitive hydrogel