title: Impact of therapy in a cohort of unselected children with Down Syndrome-associated Acute Lymphoblastic Leukaemia.
authors.affiliation: Unit of Paediatric Haematology and Oncology, Bordeaux University Hospital, Bordeaux-Cedex, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Derouet
authors.affiliation: Unit of Paediatric Haematology and Oncology, Armand Trousseau Hospital, Paris, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Petit
authors.affiliation: Unit of Paediatric Haematology and Immunology, Robert Debré Hospital, Paris, France.
authors.forename: André
authors.initials: A
authors.lastname: Baruchel
authors.affiliation: Institut National de la Santé et de la recherche Médicale (INSERM), Unit754, Registry of Malignant Hemopathies in childhood, Villejuif, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Clavel
authors.affiliation: Unit of Paediatric Haematology and Immunology, Robert Debré Hospital, Paris, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Brethon
authors.affiliation: Institute of Paediatric Haematology and Oncology, 1, place du Professeur Joseph Renault, Lyon, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Bertrand
authors.affiliation: Unit of Paediatric Haematology and Oncology, Hautepierre Hospital, Strasbourg, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Lutz
authors.affiliation: Clinical Investigation Centre in Paediatrics CIC 1401, Bordeaux University Hospital, Bordeaux-Cedex, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Nacka
authors.affiliation: Unit of Paediatric Haematology and Oncology, Bordeaux University Hospital, Bordeaux-Cedex, France. stephane.ducassou@chu-bordeaux.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ducassou
mesh_terms: D018943:Anthracyclines / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000633:toxicity; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D018943:Anthracyclines; D008727:Methotrexate
keywords: Down syndrome; acute leukaemia; therapy-related mortality; treatment