title: Pistacia Terebinthus Coffee Protects against Thioacetamide-Induced Liver Injury in Rats.
abstract: OBJECTIVE
  Pistacia terebinthus is used as a coffee substitute in the East and Southern Anatolia regions of Turkey. It contains unsaturated fatty acids, tocopherols, polyphenols and carotenoids. P. terebinthus has anti-inflammatory and potential antioxidant activity. In this study we evaluated the protective effects of P. terebinthus coffee (PTC) on thioacetamide (TAA)-induced liver injury in rats.
  
  
  METHODS
  Twenty-eight male Sprague-Dawley rats were equally randomized into four groups. Chronic liver injury was induced with TAA (100 mg/kg i.p. three times weekly). The first group of rats served as control and received only tap water (G1), and the remaining groups of rats received PTC, p.o (G2); TAA (G3); TAA plus PTC, p.o (G4), respectively.
  
  
  RESULTS
  After 8 weeks, PTC intake significantly reduced fibrosis/inflammation scores (p PTC intake reduced transforming growth factor beta (TGF-β) concentrations in the liver (p PTC intake.
  
  
  CONCLUSIONS
  PTC intake provided beneficial effects against TAA-induced liver injury in rats. PTC probably suppresses the proinflammatory cytokines through NF-κB signaling pathway.
authors.affiliation: Department of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey. ihbahcecioglu@yahoo.com.
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Bahcecioglu
authors.affiliation: Department of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ispiroglu
authors.affiliation: Department of Biology, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tuzcu
authors.affiliation: Department of Animal Nutrition, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Orhan
authors.affiliation: Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ulas
authors.affiliation: Department of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Ulvi
authors.initials: U
authors.lastname: Demirel
authors.affiliation: Department of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yalniz
authors.affiliation: Department of Pathology, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Ibrahim H
authors.initials: IH
authors.lastname: Özercan
authors.affiliation: Department of Biochemistry, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Necip
authors.initials: N
authors.lastname: Ilhan
authors.affiliation: Department of Animal Nutrition, Firat University Faculty of Medicine, Elazig, Turkey.
authors.forename: Kazim
authors.initials: K
authors.lastname: Sahin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D009676:Noxae / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects*; D027927:Pistacia; D051381:Rats; D017207:Rats, Sprague-Dawley; D000069459:Teas, Herbal; D013853:Thioacetamide / Q000633:toxicity; D016212:Transforming Growth Factor beta / Q000378:metabolism; D016896:Treatment Outcome; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D009676:Noxae; D000069459:Teas, Herbal; D016212:Transforming Growth Factor beta; D014315:Triterpenes; D013853:Thioacetamide
keywords: Inflammation; Liver fibrosis; Liver injury; Pistacia terebinthus