title: Localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model.
abstract: Localized dose delivery techniques to establish a brain radiation necrosis model are described. An irradiation field was designed by using accelerated protons or helium ions with a spread-out Bragg peak. Measurement of the designed field confirmed that a high dose can be confined to a local volume of an animal brain. The irradiation techniques described here are very useful for establishing a necrosis model without existence of extraneous complications.
authors.affiliation: Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan; The Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga-shi, Fukui 914-0192, Japan. Electronic address: taku-takata@rri.kyoto-u.ac.jp.
authors.forename: Takushi
authors.initials: T
authors.lastname: Takata
authors.affiliation: Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.affiliation: Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Hase-Tech LLC, 2-10-34-2 Matsushima-cho, Tsuruga-shi, Fukui 914-0801, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hasegawa
authors.affiliation: The Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga-shi, Fukui 914-0192, Japan.
authors.forename: Kyo
authors.initials: K
authors.lastname: Kume
authors.affiliation: Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D016754:Boron Neutron Capture Therapy / Q000009:adverse effects; D001930:Brain Injuries / Q000209:etiology* / Q000473:pathology*; D001932:Brain Neoplasms / Q000532:radiotherapy; D004307:Dose-Response Relationship, Radiation; D006371:Helium / Q000009:adverse effects; D006801:Humans; D051379:Mice; D009336:Necrosis; D011522:Protons / Q000009:adverse effects; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats
chemical_list: D011522:Protons; D006371:Helium
keywords: Accelerated ion beam; Animal model; Brain radiation necrosis; Local volume irradiation; Spread-out Bragg peak