title: Nanomedicine delivery: does protein corona route to the target or off road?
abstract: Nanomedicine aims to find novel solutions for urgent biomedical needs. Despite this, one of the most challenging hurdles that nanomedicine faces is to successfully target therapeutic nanoparticles to cells of interest in vivo. As for any biomaterials, once in vivo, nanoparticles can interact with plasma biomolecules, forming new entities for which the name protein coronas (PCs) have been coined. The PC can influence the in vivo biological fate of a nanoparticle. Thus for guaranteeing the desired function of an engineered nanomaterial in vivo, it is crucial to dissect its PC in terms of formation and evolution within the body. In this contribution we will review the 'good' and 'bad' sides of the PC, starting from the scientific aspects to the technological applications.
authors.affiliation: Fondazione Centro Europeo Nanomedicina c/o Laboratory of Nanostructured Fluorinated Materials (NFMLab), Department of Chemistry, Materials, & Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Maiolo
authors.affiliation: CIC Biomagune, San Sebastian, Spain.|Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Pablo
authors.initials: P
authors.lastname: Del Pino
authors.affiliation: Fondazione Centro Europeo Nanomedicina c/o Laboratory of Nanostructured Fluorinated Materials (NFMLab), Department of Chemistry, Materials, & Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy.|VTT-Technical Research Centre of Finland, FI-02044 VTT, Espoo, Finland.
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Metrangolo
authors.affiliation: CIC Biomagune, San Sebastian, Spain.|Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Parak
authors.affiliation: Fondazione Centro Europeo Nanomedicina c/o Laboratory of Nanostructured Fluorinated Materials (NFMLab), Department of Chemistry, Materials, & Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Baldelli Bombelli
mesh_terms: D004333:Drug Administration Routes; D050997:Nanomedicine; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: blood; drug delivery; nanomedicine; nanoparticle; nano–bio interaction; protein corona; surface; targeting