title: Chinese Herbal Products for Ischemic Stroke.
abstract: Traditional Chinese herbal products (CHPs) have been described in ancient medicine systems as treatments for various stroke-associated ailments. This study is aimed to investigate the prescription patterns and combinations of CHPs for ischemic stroke in Taiwan. Prescriptions of CHPs for ischemic stroke were obtained from the National Health Insurance Research Database (NHIRD) of Taiwan. Every prescription with a leading diagnosis of ischemic stroke made during 2000-2010 was analyzed. Descriptive statistics were applied to the pattern of co-prescriptions. Multiple logistic regression models were used to assess demographic and risk factors that are correlated with CHP use. The dataset of inpatient claims data contained information on 15,896 subjects who experienced ischemic stroke from 2000 to 2010. There was an average of 5.82 CHPs in a single prescription for subjects with ischemic stroke. Bu-yang-huan-wu-tang (BYHWT) (40.32%) was by far the most frequently prescribed formula CHP for ischemic stroke, and the most commonly used combination of two-formula-CHP was BYHWT with Shu-jin-huo-xue-tang (SJHXT) (4.40%). Dan Shen (16.50%) was the most commonly used single CHP for ischemic stroke, and the most commonly used combination of two single CHPs was Shi Chang Pua with Yuan Zhi (4.79%). We found that BYHWT and Dan Shen were the most frequently prescribed formula and single CHP for ischemic stroke, respectively. These results provide information about individualized therapy and may contribute to further pharmacologic experiments and clinical trials.
authors.affiliation: * Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: I-Ling
authors.initials: IL
authors.lastname: Hung
authors.affiliation: * Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.|‡ School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Yu-Chiang
authors.initials: YC
authors.lastname: Hung
authors.affiliation: † Department of Physical Medicine and Rehabilitation, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Lin-Yi
authors.initials: LY
authors.lastname: Wang
authors.affiliation: § Department of Chinese Medicine, China Medical University Hospital, Taipei Branch, Taiwan.|¶ Graduate Institute of Acupuncture Science, College of Public Health, China Medical University, Taichung, Taiwan.
authors.forename: Sheng-Feng
authors.initials: SF
authors.lastname: Hsu
authors.affiliation: ∥ Management Office for Health Data, College of Public Health, China Medical University,Taichung, Taiwan.
authors.forename: Hsuan-Ju
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: * Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Ying-Jung
authors.initials: YJ
authors.lastname: Tseng
authors.affiliation: * Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Chun-En
authors.initials: CE
authors.lastname: Kuo
authors.affiliation: * Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.|†† Kaohsiung Medical University College of Medicine, Kaohsiung, Taiwan.|‡‡ Fooyin University College of Nursing, Kaohsiung, Taiwan.
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Hu
authors.affiliation: ** Graduate Institute of Biostatistics, College of Public Health, China Medical University, Taichung, Taiwan.|§§ Department of Healthcare Administration, College of Health Science, Asia University Taichung, Taiwan.
authors.forename: Tsai-Chung
authors.initials: TC
authors.lastname: Li
mesh_terms: D016208:Databases, Factual / Q000706:statistics & numerical data; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional / Q000706:statistics & numerical data*; D009313:National Health Programs; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D055656:Prescriptions / Q000706:statistics & numerical data*; D027561:Salvia miltiorrhiza; D020521:Stroke / Q000188:drug therapy* / Q000453:epidemiology*; D013624:Taiwan / Q000453:epidemiology
chemical_list: D004365:Drugs, Chinese Herbal; C587029:bu-yang-huan-wu-tang
keywords: Chinese Herbal Products; Couplet Medicinal; Ischemic Stroke; Pharmaco-Epidemiology; Prescription Pattern