title: Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behçet's disease.
abstract: OBJECTIVE
  To evaluate the clinical value of capsule endoscopy (CE) in patients with intestinal Behçet's disease (BD).
  
  
  METHODS
  The present study was a case-control pilot study conducted in intestinal BD patients and healthy volunteers. A total of 19 patients with intestinal BD (intestinal BD group) and 19 healthy volunteers (control group) matched for age and sex were enrolled. Frequency, number of small bowel lesions per subject, and Lewis score were comparatively evaluated between the two groups.
  
  
  RESULTS
  Of the 19 patients with intestinal BD, 18 (94.7%) had reddened lesions, 15 (78.9%) had erosions, and nine (47.4%) had ulcers. There were significant differences in the frequency of reddened lesions (P < 0.0001), erosions (P < 0.0001) and ulcers (P = 0.0011) between the two groups. The difference in the number of small bowel lesions between the two groups was also statistically significant. The median Lewis score in the intestinal BD group was significantly higher than that in the control group (intestinal BD group 237 (0-768) vs. control group 8 (0-135); P < 0.0001). Analysis according to the location in the small bowel revealed that the frequency of ulcers tended to increase towards the distal intestine.
  
  
  CONCLUSIONS
  This is the first CE study conducted to examine small bowel involvement in intestinal BD patients. Our results suggest that CE evaluation is necessary, in addition to colonoscopy, in all intestinal BD patients.
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Jun
authors.initials: J
authors.lastname: Arimoto
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kato
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Umezawa
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Akiko
authors.initials: A
authors.lastname: Fuyuki
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Shiori
authors.initials: S
authors.lastname: Uchiyama
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Takuma
authors.initials: T
authors.lastname: Higurashi
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ohkubo
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nonaka
authors.affiliation: Division of Internal Medicine and Clinical Immunology, Yokohama City University School of Medicine, Yokohama.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Takeno
authors.affiliation: Division of Internal Medicine and Clinical Immunology, Yokohama City University School of Medicine, Yokohama.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.affiliation: Department of Gastroenterology, Kanto Medical Center NTT EC, Tokyo, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Sakai
authors.affiliation: Department of Gastroenterology, Kanto Medical Center NTT EC, Tokyo, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Matsuhashi
authors.affiliation: Division of Gastroenterology and Hepatology.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis; D053704:Capsule Endoscopy / Q000379:methods*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007410:Intestinal Diseases / Q000175:diagnosis / Q000209:etiology*; D007413:Intestinal Mucosa / Q000000981:diagnostic imaging; D007421:Intestine, Small / Q000000981:diagnostic imaging*; D008297:Male; D010865:Pilot Projects; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013997:Time Factors
keywords: capsule endoscopy; disease activity index for intestinal Behçet's disease; intestinal Behçet's disease; lewis score; small bowel lesion