title: Anti-Müllerian hormone, a Sertoli cell-derived marker, is decreased in plasma of male patients in all stages of chronic kidney disease.
abstract: Male patients with terminal renal failure are often infertile and exhibit an abnormal sex hormone pattern in plasma. We studied patients in all chronic kidney disease (CKD) stages to determine plasma levels of anti-Müllerian hormone (AMH), a Sertoli cell-derived marker, and other sex hormones. Seventy-eight male patients with CKD stages 1-5 and a median age of 40 years (22-50 years), as well as 20 healthy controls with a median age of 37 years (26-44 years), were enrolled. The CKD patients were evenly distributed; 18 with CKD stages 1-2, 19 with CKD stage 3, 19 with CKD stage 4, and 22 with CKD stage 5. Cystatin C, follicle-stimulating hormone, luteinizing hormone, prolactin, sex hormone-binding globulin, testosterone, and AMH levels in plasma were analysed. AMH was analysed using the Ansh Labs UltraSensitive AMH assay. Several changes occurred in plasma levels of sex hormones in male patients with CKD. Plasma AMH levels were lower in CKD stages 1-4 by 30% (p = 0.041) and by 70% (p < 0.001) in CKD stage 5 compared with controls. Plasma luteinizing hormone and prolactin levels were higher and testosterone levels were lower compared with controls. The pathophysiological role of this reduction in AMH is unclear, but can be linked to altered Sertoli cell function.
authors.affiliation: Department of Nephrology, Skåne University Hospital, Lund University, Malmö, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Eckersten
authors.affiliation: Reproductive Medicine Centre, Skåne University Hospital, Lund University, Malmö, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Giwercman
authors.affiliation: Department of Nephrology, Skåne University Hospital, Lund University, Malmö, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Bruun
authors.affiliation: Department of Nephrology, Skåne University Hospital, Lund University, Malmö, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Christensson
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015536:Down-Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D012708:Sertoli Cells / Q000378:metabolism*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
keywords: anti-Müllerian hormone; chronic kidney disease; infertility; male patients; renal function