title: Antiplatelet Effect of Active Components Derived from Chinese Herbal Medicine.
abstract: Atherothrombosis is the major cause of acute coronary syndromes and cardiovascular deaths. Platelets participate in the processes of forming and extending atherosclerotic plaques. Therefore, antiplatelet therapy is a milestone in the primary and second prevention of atherothrombotic diseases. Along with the longterm use of antiplatelet agents, the safety and drug resistance has become a big concern in clinic and new drugs possessing higher effectiveness and fewer adverse effects are needed. Abundant recent data support that traditional Chinese herbs may be a good alternative and complementary choice of new antiplatelet drugs. This review highlights the progress of antiplatelet effect of active components derived from traditional Chinese herbs based on their chemical structures.
authors.affiliation: Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China.|Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.|China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.|China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Ma
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. shidazhuo@126.com.|China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100091, China. shidazhuo@126.com.
authors.forename: Da-Zhuo
authors.initials: DZ
authors.lastname: Shi
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D043562:Receptors, G-Protein-Coupled
keywords: Chinese herbal medicine; active components; antiplatelet