title: Role of Chlamydia in Multiple Sclerosis.
abstract: Chlamydia and antibodies to them were detected by serological, molecular biological, and culture methods in the sera and cerebrospinal fluid of patients with multiple sclerosis and in the reference groups of subjects without neurological diseases. Correlations between the agent presence in the biological fluids of patients and clinical characteristics of the disease were analyzed. C. pneumoniae were more incident in the biological liquids of patients with multiple sclerosis than in healthy volunteers. On the other hand, the incidence of the agent in the patients was not high and its presence did not correlate with the clinical manifestations. C. trachomatis was equally rare in the patients and volunteers. The studies indicated the existence of a group of patients infected by C. pneumoniae in the cohort of patients with multiple sclerosis, but the impact of this agent for the disease course remains unclear.
authors.affiliation: Center of Neurology, Moscow, Russia. fspsbl@gmail.com.
authors.forename: M V
authors.initials: MV
authors.lastname: Ivanova
authors.affiliation: N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Kolkova
authors.affiliation: N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Morgunova
authors.affiliation: N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: Yu P
authors.initials: YP
authors.lastname: Pashko
authors.affiliation: N. F. Gamaleya Center of Epidemiology and Microbiology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Zigangirova
authors.affiliation: Center of Neurology, Moscow, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Zakharova
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid*; D015373:Bacterial Typing Techniques; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000382:microbiology* / Q000473:pathology; D002692:Chlamydia trachomatis / Q000302:isolation & purification / Q000502:physiology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification / Q000502:physiology; D004269:DNA, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000134:cerebrospinal fluid; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000382:microbiology* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: Chlamydia; multiple sclerosis