title: Characterization of spatio-temporal epidural event-related potentials for mouse models of psychiatric disorders.
abstract: Distinctive features in sensory event-related potentials (ERPs) are endophenotypic biomarkers of psychiatric disorders, widely studied using electroencephalographic (EEG) methods in humans and model animals. Despite the popularity and unique significance of the mouse as a model species in basic research, existing EEG methods applicable to mice are far less powerful than those available for humans and large animals. We developed a new method for multi-channel epidural ERP characterization in behaving mice with high precision, reliability and convenience and report an application to time-domain ERP feature characterization of the Sp4 hypomorphic mouse model for schizophrenia. Compared to previous methods, our spatio-temporal ERP measurement robustly improved the resolving power of key signatures characteristic of the disease model. The high performance and low cost of this technique makes it suitable for high-throughput behavioral and pharmacological studies.
authors.affiliation: Howard Hughes Medical Institute and the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Howard Hughes Medical Institute and the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: António
authors.initials: A
authors.lastname: Pinto-Duarte
authors.affiliation: Howard Hughes Medical Institute and the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: M Margarita
authors.initials: MM
authors.lastname: Behrens
authors.affiliation: Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093, USA.
authors.forename: Xianjin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Howard Hughes Medical Institute and the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.|Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA.
authors.forename: Terrence J
authors.initials: TJ
authors.lastname: Sejnowski
mesh_terms: D000818:Animals; D001931:Brain Mapping; D004195:Disease Models, Animal; D004569:Electroencephalography; D005071:Evoked Potentials; D001523:Mental Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D051379:Mice; D012559:Schizophrenia / Q000503:physiopathology