title: [Comparison of clinical characteristics of non-B non-C hepatocellular carcinoma and hepatitis virus-related hepatocellular carcinoma and prognosis in Uighur patients].
abstract: OBJECTIVE
  This study was aimed to understand the clinical characteristics and prognosis in Uighur patients with Non-B Non-C hepatocellular carcinoma (HCC) and virus-related HCC.
  
  
  METHODS
  We retrospectively analyzed the clinical data of 301 Uighur HCC patients, among them, there were 145 NBC-HCC cases and 156 virus-related HCC cases. The overall survival rates of the patients were analyzed by Kaplan-Meier method, and the factors that may influence the prognosis and survival of NBC-HCC patients were analyzed using univariate (Log rank test) and multivariate Cox proportional hazard model.
  
  
  RESULTS
  The differences of the gender, living region, history of diabetes, body mass index (BMI), history of cirrhosis, TNM stage, Child-Pugh scores, total bilirubin, and AFP level between the NBC-HCC group and viral-HCC group were statistically significant (P < 0.05 for all). The 1-, 2-, 3- and 5-year survival rates were 35.6%, 20.3%, 12.6%, and 4.5%, respectively, for all the 301 patients, and no significant difference between these two groups in terms of OS (P > 0.05). Multivariate analysis by Cox model showed that age, TNM staging, PVTT, Child-Pugh scores, TACE combined with radiotherapy or RFA were significant independent prognostic factors (all P < 0.05).
  
  
  CONCLUSIONS
  The clinical characteristics in Uighur patients with non-B non-C HCC and hepatitis virus-related HCC are not all the same and HCC in Xinjiang region has certain regional characteristics and features. Age, TNM stages, portal vein tumor thrombus, Child-Pugh scores, and TACE combined with radiotherapy or RFA are significant independent prognostic factors.
authors.affiliation: Tumor Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang 830054, China.
authors.forename: Ruili
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Tumor Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang 830054, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Tumor Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang 830054, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Tumor Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang 830054, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Tumor Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang 830054, China.
authors.forename: Aisikeer
authors.initials: A
authors.lastname: Tulahong
authors.affiliation: Tumor Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang 830054, China.
authors.forename: Yuefen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Tumor Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang 830054, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
authors.affiliation: Tumor Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang 830054, China; Email: baoyx@vip.sina.com.
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Bao
mesh_terms: D000367:Age Factors; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000401:mortality / Q000628:therapy / Q000821:virology*; D005260:Female; D006526:Hepatitis C / Q000821:virology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000208:ethnology / Q000401:mortality / Q000628:therapy / Q000821:virology*; D008297:Male; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011169:Portal Vein; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate; D013927:Thrombosis; D016896:Treatment Outcome