title: Outcomes of 18 cases with squamous cell carcinoma of middle ear who underwent both surgery and post-operative radiotherapy.
abstract: CONCLUSIONS
  Early diagnosis and treatment were critical to prevent recurrence, and the long-term outcomes were satisfactory after surgery and post-operative radiotherapy.
  
  
  OBJECTIVE
  To present outcomes of 18 cases with squamous cell carcinoma of the middle ear who underwent both surgery and post-operative radiotherapy.
  
  
  METHODS
  Eighteen cases with squamous cell carcinoma of the middle ear (two cases of T1, five of T2, and 11 of T3) underwent surgery and post-operative radiotherapy, and a surgical approach was determined by tumour sites. Extended mastoidotympanectomy was performed on two cases, with subtotal temporal bone resection on 12 cases and temporal bone resection on four cases. The patients who had cervical metastasis underwent additional radical neck resection and post-operative radiotherapy at the neck. The patients were followed-up after surgery.
  
  
  RESULTS
  During the follow-up, no cases of T1 recurred, and six cases of T2 or T3 recurred, with the total recurrence rate of 37.5% among the patients of T2 and T3. At the fifth year after surgery, 15 patients were still alive, and the actual 5-year survival rate was 83.3% among all patients.
authors.affiliation: a Department of Otolaryngology , Cangzhou Central Hospital , Cangzhou , Hebei Province , PR China.
authors.forename: Lichun
authors.initials: L
authors.lastname: Feng
authors.affiliation: a Department of Otolaryngology , Cangzhou Central Hospital , Cangzhou , Hebei Province , PR China.
authors.forename: Aiyan
authors.initials: A
authors.lastname: Jin
authors.affiliation: a Department of Otolaryngology , Cangzhou Central Hospital , Cangzhou , Hebei Province , PR China.
authors.forename: Baoqiang
authors.initials: B
authors.lastname: Dai
authors.affiliation: a Department of Otolaryngology , Cangzhou Central Hospital , Cangzhou , Hebei Province , PR China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Li
authors.affiliation: b Department of Otolaryngology , People's Hospital of Yanshan County , Cangzhou , PR China.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Guo
authors.affiliation: c Department of Otolaryngology, Head and Neck Surgery , Peking University Health Science Center , Beijing , PR China.
authors.forename: Daowen
authors.initials: D
authors.lastname: Wang
authors.affiliation: a Department of Otolaryngology , Cangzhou Central Hospital , Cangzhou , Hebei Province , PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D002681:China / Q000453:epidemiology; D018572:Disease-Free Survival; D004428:Ear Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D004432:Ear, Middle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013506:Otologic Surgical Procedures / Q000379:methods*; D011182:Postoperative Care / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome
keywords: Squamous cell carcinoma; middle ear; radiotherapy; temporal bone resection