title: Low Serum Level α-Synuclein and Tau Protein in Autism Spectrum Disorder Compared to Controls.
abstract: α-Synuclein (α-syn) and tau proteins are thought to be related with the synaptic loss and cell death underlying several important neurodegenerative diseases. The aim of our study was to investigate serum α-syn and tau levels in autism. Serum levels of α-syn and tau were measured, and autism spectrum disorder (ASD) severity was assessed at admission using the Childhood Autism Rating Scale (CARS) total score. The mean CARS score of the autism group on admission was 47.91 points (SD: 5.97). The results indicated that the mean serum α-syn and serum tau levels were significantly (p < 0.001) lower in children with ASD as compared with normal cases (33.01 ± 20.78 and 55.19 ± 15.34 ng/mL and 241.23 ± 290.5 and 509.78 ± 269.25 ng/mL, respectively). There was a significant positive correlation between serum α-syn levels and serum levels of tau identified by Pearson correlation analysis (r = 0.922, n = 28, p < 0.001). Synaptic abnormality in autism may result from microglial activity. Furthermore, α-syn and tau aggregation may lead to synaptic dysfunction, and this may contribute to either neuronal or synaptic dysfunction or neurodegeneration. Our preliminary study suggests that low levels of serum α-syn and tau may be implicated in the relationship between synaptic activity and autism.
authors.affiliation: Department of Child and Adolescent Psychiatry, Cerrahpaşa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Muhammed Tayyib
authors.initials: MT
authors.lastname: Kadak
authors.affiliation: Department of Nutrition and Dietetics, School of Health, Batman University, Batman, Turkey.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Cetin
authors.affiliation: Clinics of Child and Adolescent Psychiatry, Bakırköy Dr Sadi Konuk Training and Education Hospital, Istanbul, Turkey.
authors.forename: Mahmut Cem
authors.initials: MC
authors.lastname: Tarakçıoğlu
authors.affiliation: Department of Biochemistry, Bezmi Alem Vakıf University, Istanbul, Turkey.
authors.forename: Ömer Faruk
authors.initials: ÖF
authors.lastname: Özer
authors.affiliation: Department of Psychiatry, Cerrahpaşa School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Kaçar
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey.
authors.forename: Behzat
authors.initials: B
authors.lastname: Çimen
mesh_terms: D000067877:Autism Spectrum Disorder / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D051844:alpha-Synuclein / Q000097:blood*; D016875:tau Proteins / Q000097:blood*
chemical_list: D051844:alpha-Synuclein; D016875:tau Proteins