title: [RESEARCH PROGRESS OF ANGIOGENESIS IN VASCULARIZED TISSUE ENGINEERED BONE].
abstract: OBJECTIVE
  To review the research progress of the role of seed cells and related cytokines in angiogenesis of the vascularized tissue engineered bone.
  
  
  METHODS
  The latest literature of tissue engineered bone angiogenesis was reviewed, including the common source of seed cells, biological characteristics, transformation mechanism, related cytokines, and signaling pathways in re-vascularization.
  
  
  RESULTS
  Microsurgery technique, genetic technique, and co-culture system of vascularized tissue engineered bone have developed to a new level. Moreover, both the induction of introduced pluripotent stem cells and vascular endothelial growth factor-angiopoietins 1 transfected mesenchymal stem cells and endothelial progenitor cells have some advantages for bone regeneration and vascularization. However, all the techniques were not used in clinical practice.
  
  
  CONCLUSIONS
  Using techniques of genetically modified seed cells, related cytokines, and scaffolds may have bright prospects for building vascularized tissue engineered bone.
authors.forename: Xin
authors.initials: X
authors.lastname: Duan
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xiang
mesh_terms: D020533:Angiogenesis Inhibitors; D042683:Angiopoietin-1 / Q000235:genetics / Q000378:metabolism*; D001861:Bone Regeneration; D001842:Bone and Bones / Q000098:blood supply / Q000166:cytology; D018929:Cell Culture Techniques / Q000379:methods; D018920:Coculture Techniques / Q000379:methods; D066026:Endothelial Progenitor Cells; D006801:Humans; D059630:Mesenchymal Stem Cells; D009389:Neovascularization, Pathologic; D010012:Osteogenesis; D039904:Pluripotent Stem Cells / Q000378:metabolism*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D042461:Vascular Endothelial Growth Factor A
chemical_list: D020533:Angiogenesis Inhibitors; D042683:Angiopoietin-1; D042461:Vascular Endothelial Growth Factor A