title: Protease inhibitor monotherapy is effective in controlling human immunodeficiency virus 1 shedding in the male genital tract.
abstract: Cross-sectional study comparing seminal human immunodeficiency virus type 1 (HIV-1) shedding in patients receiving boosted protease inhibitor monotherapy (mtPI/rtv) (n = 66) versus triple therapy (TT) (n = 61). Seminal HIV-1 shedding rates in patients with undetectable plasma HIV-RNA were 16.0% on mtPI/rtv compared with 28.6% on TT (p 0.173). Aviraemic status and time on viral suppression were independently associated with lack of seminal HIV-1 shedding. During TT, non PI/rtv-based regimens were associated with a better control of HIV infection in semen despite similar time on viral suppression. The use of mtPI/rtv in well-controlled patients is not associated with increased seminal HIV excretion compared with TT.
authors.affiliation: Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain. Electronic address: ATORRES-CORNEJO@mgh.harvard.edu.
authors.forename: A
authors.initials: A
authors.lastname: Torres-Cornejo
authors.affiliation: Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: O J
authors.initials: OJ
authors.lastname: BenMarzouk-Hidalgo
authors.affiliation: Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Viciana
authors.affiliation: Servicio de Inmunología, Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Sánchez
authors.affiliation: Enfermedades Infecciosas, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario Virgen de las Nieves, Granada, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: López-Ruz
authors.affiliation: Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain. Electronic address: lflopez@us.es.
authors.forename: L F
authors.initials: LF
authors.lastname: López-Cortés
authors.affiliation: Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gutiérrez-Valencia
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012661:Semen / Q000821:virology*; D016896:Treatment Outcome; D017201:Virus Shedding / Q000187:drug effects*
chemical_list: D017320:HIV Protease Inhibitors
keywords: Human immunodeficiency virus 1 infection; human immunodeficiency virus 1 treatment; male genital tract; protease inhibitor monotherapy; triple therapy