title: Proton Pump Inhibitors, Platelet Reactivity, and Cardiovascular Outcomes After Drug-Eluting Stents in Clopidogrel-Treated Patients: The ADAPT-DES Study.
abstract: BACKGROUND
  Certain proton pump inhibitors (PPIs) interfere with clopidogrel metabolism, potentially attenuating P2Y12 receptor inhibition. Previous observational and randomized trials report conflicting results regarding the clinical significance of this pharmacological interaction. We examined the interaction between concomitant administration of PPI and clopidogrel on platelet reactivity and clinical outcomes in the large-scale, prospective Assessment of Dual AntiPlatelet Therapy With Drug-Eluting Stents study.
  
  
  RESULTS
  On-treatment P2Y12 platelet reactivity testing was performed using the VerifyNow assay after clopidogrel loading and successful drug-eluting stent implantation at 11 sites in the United States and Germany. PPIs were prescribed at the discretion of treating physicians; patients were followed for 2 years. High platelet reactivity was defined as P2Y12 reactivity units >208. Of 8582 enrolled patients, 2697 (31.4%) were taking a PPI at the time of coronary intervention. After adjustment for differences in baseline characteristics, PPI use was independently associated with high platelet reactivity (odds ratio, 1.38: 95% confidence interval, 1.25-1.52, P=0.0001). A total of 2162 (25.2%) patients were prescribed a PPI at hospital discharge. In a propensity-adjusted multivariable analysis, discharge PPI use was independently associated with increased risk for postdischarge major adverse cardiac events (cardiac death, myocardial infarction, or ischemia-driven target lesion revascularization) at 2-year follow-up (hazard ratio, 1.21; 95% confidence interval, 1.04-1.42, P=0.02).
  
  
  CONCLUSIONS
  In patients treated with clopidogrel after successful drug-eluting stents implantation, the concomitant administration of PPI was associated with high platelet reactivity and a greater rate of adverse outcomes during long-term follow-up. Additional studies are warranted to determine the risk-benefit ratio of PPIs in patients with drug-eluting stents treated with clopidogrel.
  
  
  BACKGROUND
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT00433966.
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.). weiszg@szmc.org.il.
authors.forename: Giora
authors.initials: G
authors.lastname: Weisz
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Nathaniel R
authors.initials: NR
authors.lastname: Smilowitz
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Ajay J
authors.initials: AJ
authors.lastname: Kirtane
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rinaldi
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Rupa
authors.initials: R
authors.lastname: Parvataneni
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Stuckey
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Akiko
authors.initials: A
authors.lastname: Maehara
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Bernhard
authors.initials: B
authors.lastname: Witzenbichler
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Franz-Josef
authors.initials: FJ
authors.lastname: Neumann
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: D Christopher
authors.initials: DC
authors.lastname: Metzger
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Henry
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: David A
authors.initials: DA
authors.lastname: Cox
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Peter L
authors.initials: PL
authors.lastname: Duffy
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Brodie
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Ernest L
authors.initials: EL
authors.lastname: Mazzaferri
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Roxana
authors.initials: R
authors.lastname: Mehran
authors.affiliation: From the Shaare Zedek Medical Center, Jerusalem, Israel (G.W.); NYU Langone Medical Center, New York, NY (N.R.S.); NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, NY (G.W., A.J.K., A.M., G.W.S.); Cardiovascular Research Foundation, New York, NY (G.W., A.J.K., R.P., K.X., A.M., R.M., G.W.S.); Sanger Heart and Vascular Institute/Carolinas HealthCare System, Charlotte, NC (M.J.R.); LeBauer Cardiovascular Research Foundation/Cone Health, Greensboro, NC (T.D.S., B.R.B.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.); Cedars-Sinai Medical Center, Los Angeles, CA (T.D.H.); Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.); Lehigh Valley Health Network, Allentown, PA (D.A.C.); Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.); The Ohio State University Wexner Medical Center, Columbus, OH (E.L.M.); and Icahn School of Medicine at Mount Sinai, New York, NY (R.M.).
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
mesh_terms: D000368:Aged; D019917:Blood Vessel Prosthesis Implantation; D000077144:Clopidogrel; D004347:Drug Interactions; D054855:Drug-Eluting Stents / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000187:drug effects; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D014481:United States
chemical_list: D054328:Proton Pump Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: antiplatelet; drug-eluting stent; percutaneous coronary intervention; platelet inhibition; proton pump inhibitor