title: [Inhaled treatments: Choice of devices, systemic absorption of inhaled drugs and bitter taste receptors in the respiratory tract].
abstract: Inhaled drugs are now routinely prescribed in daily medical practice. Recent topics about these treatments have been developed during the fourth annual meeting of the Groupe de travail aérosolthérapie (GAT) of the French-speaking respiratory society (Société de pneumologie de langue française). This article focuses mainly upon the choice of devices, systemic absorption of inhaled drugs and bitter taste receptors in the respiratory tract, a potential new target for drug development.
authors.affiliation: Service de pneumologie et unité de soins intensifs respiratoires, CHU de Rouen, 76031 Rouen, France. Electronic address: amira.benattia@chu-rouen.fr.
authors.forename: A
authors.initials: A
authors.lastname: Benattia
authors.affiliation: Inhalexpert, 92500 Rueil-Malmaison, France.
authors.forename: P
authors.initials: P
authors.lastname: Cavaillon
authors.affiliation: Unité de pneumologie pédiatrique, CHU Timone-Enfants, 13385 Marseille cedex 5, France.
authors.forename: E
authors.initials: E
authors.lastname: Gachelin
authors.affiliation: UPRES EA220, université Versailles-Saint-Quentin, hôpital Foch, 92150 Suresnes, France.
authors.forename: P
authors.initials: P
authors.lastname: Devillier
authors.affiliation: EA6305, CEPR, faculté de médecine, université François-Rabelais, 37032 Tours, France; DTF-aerodrug, faculté de médecine, 37032 Tours, France.
authors.forename: L
authors.initials: L
authors.lastname: Vecellio
authors.affiliation: Aptar Pharma, 27100 Le Vaudreuil, France.
authors.forename: G
authors.initials: G
authors.lastname: Williams
authors.affiliation: Unité de pneumologie pédiatrique, CHU Timone-Enfants, 13385 Marseille cedex 5, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Dubus
mesh_terms: D000280:Administration, Inhalation; D000335:Aerosol Propellants; D000336:Aerosols; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D004867:Equipment Design; D005100:Expectorants / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000493:pharmacokinetics; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D009126:Muscle Relaxation / Q000187:drug effects; D032389:Myocytes, Smooth Muscle / Q000187:drug effects / Q000502:physiology; D009330:Nebulizers and Vaporizers / Q000145:classification; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000502:physiology; D012137:Respiratory System / Q000187:drug effects; D014018:Tissue Distribution; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D000098706:Taste Receptors, Type 2
chemical_list: D000335:Aerosol Propellants; D000336:Aerosols; D000890:Anti-Infective Agents; D001993:Bronchodilator Agents; D005100:Expectorants; D007328:Insulin; D043562:Receptors, G-Protein-Coupled; D014665:Vasodilator Agents; D000098706:Taste Receptors, Type 2
keywords: Aérosol-doseurs pressurisés; Bitter taste receptors; Chambres d’inhalation; Inhaled drugs; Nebulizers; Nébuliseurs; Pressurized metered-dose inhalers; Récepteurs à l’amertume; Spacer devices; Traitements inhalés