title: Lorcaserin Hcl for the treatment of obesity.
abstract: BACKGROUND
  Obesity is a major health priority necessitating safe and effective strategies to address the obesity epidemic. Lorcaserin is a serotonergic agonist specific to the 5HT- 2C receptor approved for chronic management of obesity in patients with a BMI ≥ 30 kg/m(2) or a BMI ≥ 27 kg/m(2) with comorbidities related to obesity.
  
  
  METHODS
  In this paper, the pharmacodynamic and pharmacokinetic properties of lorcaserin are reviewed followed by a discussion of efficacy and safety data from major clinical trials.
  
  
  CONCLUSIONS
  Lorcaserin is a unique highly selective serotonergic agonist designed to mitigate the risks associated with previous agents in this class. At therapeutic doses, it is well tolerated and produces modest but clinically meaningful weight loss with significant improvement in cardiometabolic parameters. Therapeutic efficacy should be assessed at 12 weeks (≥ 5% weight loss) to identify responders who will derive maximum weight loss and metabolic benefit from long-term therapy. The results of the ongoing cardiovascular outcomes trial (CAMELLIA TIMI 61) will determine the role of lorcaserin in primary prevention of diabetes in overweight/obese individuals and its use in the high-risk population of patients with established cardiovascular disease or multiple cardiovascular risk factors.
authors.affiliation: a Weill Cornell Medical College, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes & Metabolism , NY, USA ljaronne@med.cornell.edu.
authors.forename: Alpana P
authors.initials: AP
authors.lastname: Shukla
authors.affiliation: a Weill Cornell Medical College, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes & Metabolism , NY, USA ljaronne@med.cornell.edu.
authors.forename: Rekha B
authors.initials: RB
authors.lastname: Kumar
authors.affiliation: a Weill Cornell Medical College, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes & Metabolism , NY, USA ljaronne@med.cornell.edu.
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Aronne
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001552:Benzazepines / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D009765:Obesity / Q000188:drug therapy*; D058826:Serotonin 5-HT2 Receptor Agonists / Q000627:therapeutic use*
chemical_list: D019440:Anti-Obesity Agents; D001552:Benzazepines; D058826:Serotonin 5-HT2 Receptor Agonists; C506658:lorcaserin
keywords: 5HT2C agonist; behavioral modification and lorcaserin for overweight and obesity management; behavioral modification and lorcaserin second study for obesity management; lorcaserin; obesity