title: [An improvement of experimental model for a study of local hemostatic agents' effectiveness].
abstract: With the help of tests on 10 big biological objects (sheep) was studied a modern model of severe lateral damage (6 mm diameter) of femoral artery. Within 45 seconds blood loss was 432.5 +/- 258.2 ml. The usage of domestic local hemostatic agent--"Gemostop" based on zeolite and "Gemofleks" based on chitosan. The total three-hour mortality was 50%. Primary hemostasis was recorded only in 20% of biological objects, the final hemostasis in 60%. Thus, the model of standard 6-mm lateral damage of femoral artery with a free primary hemmorage during 45 seconds should be considered as. optimal for evaluating the effectiveness of modern hemostatic agents.
authors.forename: I M
authors.initials: IM
authors.lastname: Samokhvalov
authors.forename: V A
authors.initials: VA
authors.lastname: Reva
authors.forename: A V
authors.initials: AV
authors.lastname: Denisov
authors.forename: K P
authors.initials: KP
authors.lastname: Golovko
authors.forename: M V
authors.initials: MV
authors.lastname: Sokhranov
authors.forename: S Yu
authors.initials: SY
authors.lastname: Telitskii
authors.forename: A B
authors.initials: AB
authors.lastname: Yudin
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005263:Femoral Artery / Q000293:injuries*; D006470:Hemorrhage / Q000517:prevention & control*; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use*; D012756:Sheep; D016896:Treatment Outcome; D014950:Wounds, Penetrating / Q000150:complications*
chemical_list: D006490:Hemostatics