title: Prenatal interventions to prevent bronchopulmonary dysplasia in animal models: a systematic review.
abstract: OBJECTIVE
  The objective of this study is to identify and systematically review in vivo animal studies on antenatal medical interventions to prevent bronchopulmonary dysplasia.
  
  
  METHODS
  An automated literature search was conducted using MEDLINE (Pubmed) and Embase including all studies using Medical Subject Headings (MeSH) and keywords following a step-by-step approach. All in vivo prenatal intervention studies in animal models mimicking key aspects of the pathophysiology of bronchopulmonary dysplasia were included. In view of relevance of the findings, an additional criterion was that outcomes at 48 h of life or beyond were available. The PRISMA statement concerning systemic reviews was applied and a quality checklist developed by the CAMARADES group was used.
  
  
  RESULTS
  In total, 518 abstracts were identified yet only eight studies were eligible for further analysis. Four studies involved administration of glucocorticoids, the other studies described therapy with epidermal growth factor, interleukin 1b, beta-naphthoflavone, or vitamin D. Outcomes were survival, pulmonary histology, lung function, and/or biochemical analysis.
  
  
  CONCLUSIONS
  Though many in vivo experimental studies in animal models for bronchopulmonary dysplasia have been done, only few have looked into the effect of prenatal interventions and measured outcomes after at least 48 h of life. Most involve the use of antenatal glucocorticoids, although still only four.
authors.affiliation: a Cluster Organ Systems, Department of Development and Regeneration, Group Biomedical Sciences, KU Leuven , Leuven , Belgium .|b Department of Obstetrics and Gynaecology , Clínica Alemana , Santiago , Chile .
authors.forename: Julio
authors.initials: J
authors.lastname: Jimenez
authors.affiliation: a Cluster Organ Systems, Department of Development and Regeneration, Group Biomedical Sciences, KU Leuven , Leuven , Belgium .|c Department of Obstetrics and Gynaecology , University Hospitals KU Leuven , Leuven , Belgium .
authors.forename: Jute
authors.initials: J
authors.lastname: Richter
authors.affiliation: a Cluster Organ Systems, Department of Development and Regeneration, Group Biomedical Sciences, KU Leuven , Leuven , Belgium .|d Department of Paediatrics , University Hospitals KU Leuven , Leuven , Belgium , and.
authors.forename: Jaan
authors.initials: J
authors.lastname: Toelen
authors.affiliation: a Cluster Organ Systems, Department of Development and Regeneration, Group Biomedical Sciences, KU Leuven , Leuven , Belgium .|c Department of Obstetrics and Gynaecology , University Hospitals KU Leuven , Leuven , Belgium .|e University College London Hospital, Institute for Woman's Health and Great Ormond Street Hospital , London.
authors.forename: Jan
authors.initials: J
authors.lastname: Deprest
mesh_terms: D000818:Animals; D001997:Bronchopulmonary Dysplasia / Q000517:prevention & control*; D005260:Female; D005325:Fetal Organ Maturity / Q000187:drug effects; D005865:Gestational Age; D005938:Glucocorticoids / Q000008:administration & dosage*; D008168:Lung / Q000196:embryology; D016239:MEDLINE; D023421:Models, Animal; D009316:National Institutes of Health (U.S.); D011247:Pregnancy; D047928:Premature Birth; D011295:Prenatal Care; D014481:United States
chemical_list: D005938:Glucocorticoids
keywords: Animal model; bronchopulmonary dysplasia; prenatal treatment; systematic review