title: Glutathione S-transferase P1, gene-gene interaction, and lung cancer susceptibility in the Chinese population: An updated meta-analysis and review.
abstract: OBJECTIVE
  To assess the impact of glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism on the risk of lung cancer in the Chinese population, an updated meta-analysis and review was performed.
  
  
  METHODS
  Relevant studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine published through January 22, 2015. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations.
  
  
  RESULTS
  A total of 13 case-control studies, including 2026 lung cancer cases and 2451 controls, were included in this meta-analysis. Overall, significantly increased lung cancer risk was associated with the variant genotypes of GSTP1 polymorphism in the Chinese population (GG vs. AA: OR=1.36, 95% CI=1.01-1.84). In subgroup analyses stratified by geographic area and source of controls, the significant results were found in population-based studies (GG vs. AA: OR=1.62, 95% CI: 1.13-2.31; GG vs. AG: OR=1.49, 95% CI: 1.03-2.16; GG vs. AA+AG: OR=1.55, 95% CI: 1.12-2.26). A gene-gene interaction analysis showed that there was an interaction for individuals with combination of GSTM1 (or GSTT1) null genotype and GSTP1 (AG+GG) mutant genotype for lung cancer risk in Chinese.
  
  
  CONCLUSIONS
  This meta-analysis suggests that GSTP1 Ile105Val polymorphism may increase the risk of lung cancer in the Chinese population.
authors.affiliation: Department of Respiration, Changzhou Traditional Chinese Medicine Hospital, Changzhou 213000, China.
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Li
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Yu
authors.forename: Ye
authors.initials: Y
authors.lastname: Yuan
authors.forename: Ming-Zhi
authors.initials: MZ
authors.lastname: Pu
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Zhang
authors.forename: Ke-Jian
authors.initials: KJ
authors.lastname: Wang
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Han
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D004843:Epistasis, Genetic; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human