title: RANK rs1805034 T>C Polymorphism Is Associated with Susceptibility to Gastric Cardia Adenocarcinoma in a Chinese Population.
abstract: BACKGROUND
  Gastric cardia adenocarcinoma (GCA) is a common malignant tumor of the digestive tract with a high incidence in China. Genetic factors such as single nucleotide polymorphisms (SNPs) may contribute to the carcinogenesis of GCA.
  
  
  METHODS
  We conducted a hospital-based case-control study to evaluate the genetic association of functional SNPs with susceptibility to GCA development. A total of 330 GCA cases and 608 controls were recruited for this study. The SNPs OPG rs3102735 T>C and rs2073618 G>C, RANK rs1805034 T>C, and RANKL rs9533156 T>C and rs2277438 A>G were determined using the ligation detection reaction method.
  
  
  RESULTS
  Our findings suggest that RANK rs1805034 T>C is associated with susceptibility to GCA, which is more evident among male patients, elderly patients (≥ 60 years), smokers, and patients who do not consume alcohol.
  
  
  CONCLUSIONS
  Based on our findings, the functional SNP RANK rs1805034 T>C may be an indicator for individual susceptibility to GCA. However, further larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm the current findings.
authors.affiliation: Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Zhang
authors.forename: Hai-Yong
authors.initials: HY
authors.lastname: Gu
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Shi
authors.forename: Ai-Zhong
authors.initials: AZ
authors.lastname: Shao
authors.forename: Suo-Cheng
authors.initials: SC
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Jiang
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000235:genetics*; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000235:genetics*; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology*; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human