title: Family history of diabetes and the risk of subclinical atherosclerosis.
abstract: OBJECTIVE
  This study investigated the influence of a family history of diabetes on the risk of subclinical coronary atherosclerosis according to coronary computed tomography angiography (CCTA) in asymptomatic individuals.
  
  
  METHODS
  A total of 6434 consecutive asymptomatic individuals with no prior history of coronary artery disease voluntarily underwent CCTA evaluation as part of a general health examination. Coronary atherosclerotic plaque and significant coronary artery stenosis (degree of stenosis ≥50%) on CCTA were assessed. Logistic regression analysis was used to determine the association between a family history of diabetes and atherosclerotic plaque or significant coronary artery stenosis according to the degree of diabetes (normal, prediabetic and diabetic).
  
  
  RESULTS
  Mean age of study participants was 53.7±7.6 years, and 4694 (73.0%) were male. A total of 1593 (24.8%) participants had a family history of diabetes in a first-degree relative. Among the study participants, 1115 (17.3%), 3122 (48.5%) and 2197 (34.1%) were categorized as diabetic, prediabetic and normal, respectively. In diabetic participants, after stepwise adjustments for clinical and laboratory variables, a family history of diabetes was significantly associated with non-calcified plaque (P<0.05 for all), but did not appear to be associated with either calcified or mixed plaques or with significant coronary artery stenosis (P>0.05 for all). In prediabetic and normal participants, a family history of diabetes was not associated with either atherosclerotic plaque or significant coronary artery stenosis (P>0.05 for all).
  
  
  CONCLUSIONS
  In asymptomatic diabetic individuals, a family history of diabetes is consistently associated with non-calcified coronary plaque after adjusting for risk factors.
authors.affiliation: Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
authors.forename: G-M
authors.initials: GM
authors.lastname: Park
authors.affiliation: Department of Cardiology, Dong-A University Hospital, Busan, Korea.
authors.forename: Y-R
authors.initials: YR
authors.lastname: Cho
authors.affiliation: Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address: seungwlee@amc.seoul.kr.
authors.forename: S-W
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Department of Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: S-C
authors.initials: SC
authors.lastname: Yun
authors.affiliation: Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
authors.forename: E H
authors.initials: EH
authors.lastname: Gil
authors.affiliation: Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
authors.forename: D W
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
authors.forename: T-S
authors.initials: TS
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
authors.forename: C J
authors.initials: CJ
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
authors.forename: J S
authors.initials: JS
authors.lastname: Cho
authors.affiliation: Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
authors.forename: M-W
authors.initials: MW
authors.lastname: Park
authors.affiliation: Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Her
authors.affiliation: Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Y-H
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: D H
authors.initials: DH
authors.lastname: Yang
authors.affiliation: Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: J-W
authors.initials: JW
authors.lastname: Kang
authors.affiliation: Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: T-H
authors.initials: TH
authors.lastname: Lim
authors.affiliation: Department of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: C H
authors.initials: CH
authors.lastname: Jung
authors.affiliation: Department of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: E H
authors.initials: EH
authors.lastname: Koh
authors.affiliation: Department of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: W J
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: Department of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: M-S
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: K-U
authors.initials: KU
authors.lastname: Lee
authors.affiliation: The Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: H-K
authors.initials: HK
authors.lastname: Kim
authors.affiliation: The Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Choe
authors.affiliation: Department of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Park
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D017023:Coronary Angiography; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging / Q000453:epidemiology*; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging / Q000453:epidemiology*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
keywords: Atherosclerosis; Coronary artery disease; Diabetes; Family history