title: Investigation of neutrophil-to-lymphocyte ratio and mean platelet volume in sudden hearing loss.
abstract: BACKGROUND
  Several theories attempt to explain the pathophysiology of sudden hearing loss.
  
  
  OBJECTIVE
  The objective of this study was to investigate the possible role of inflammation and atherothrombosis in sudden hearing loss patients through the neutrophil-to-lymphocyte ratio and mean platelet volume.
  
  
  METHODS
  Study design - retrospective cross-sectional historical cohort. This study was conducted on two groups: one with 59 individuals diagnosed with sudden hearing loss, and other with 59 healthy individuals with the same characteristics of gender and age distribution, neutrophil-to-lymphocyte ratio and mean platelet volume levels were measured in patients diagnosed with sudden hearing loss as well as in the control group, and it was verified whether these results interfered for a better or worse prognosis with treatment of sudden deafness.
  
  
  RESULTS
  Neutrophil-to-lymphocyte ratio levels are much higher in patients diagnosed with sudden hearing loss compared to the control group. Similarly, mean levels of neutrophil-to-lymphocyte ratio are higher in non-recovered versus recovered patients (p=0.001). However, we could not find a correlation with mean platelet volume levels (p>0.05).
  
  
  CONCLUSIONS
  Neutrophil-to-lymphocyte ratio is a quick and reliable indicator regarding diagnosis and prognosis of sudden hearing loss; on the other hand, mean platelet volume may be considered a less important indicator in this aspect.
authors.affiliation: Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey. Electronic address: adigerok@yahoo.com.tr.
authors.forename: Rauf Oğuzhan
authors.initials: RO
authors.lastname: Kum
authors.affiliation: Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey.
authors.forename: Muge
authors.initials: M
authors.lastname: Ozcan
authors.affiliation: Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Baklaci
authors.affiliation: Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey.
authors.forename: Nurcan
authors.initials: N
authors.lastname: Yurtsever Kum
authors.affiliation: Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey.
authors.forename: Yavuz Fuat
authors.initials: YF
authors.lastname: Yilmaz
authors.affiliation: Department of Otorhinolaryngology, Hitit University, Çorum, Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Unal
authors.affiliation: Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey.
authors.forename: Yonca
authors.initials: Y
authors.lastname: Avci
mesh_terms: D000328:Adult; D015415:Biomarkers; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology; D003639:Hearing Loss, Sudden / Q000097:blood*; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers
keywords: Biological markers; Hearing loss, sensorineural; Hearing loss, sudden; Linfócitos; Lymphocyte count; Marcadores biológicos; Neutrophils; Neutrófilos; Perda auditiva neurossensorial; Perda auditiva súbita; Plaquetas; Platelet count