title: Regioselective synthesis of multisubstituted isoquinolones and pyridones via Rh(III)-catalyzed annulation reactions.
abstract: A mild and efficient Rh(III)-catalyzed regioselective synthesis of isoquinolones and pyridones has been developed. The protocol uses readily available N-methoxybenzamide or N-methoxymethacrylamide and diazo compounds as starting materials. The process involving tandem C-H activation, cyclization, and condensation steps proceeds under mild conditions, and the corresponding isoquinolone and pyridone derivatives were obtained in good to excellent yields with excellent regioselectivities. The process provides a facile approach for the construction of isoquinolone and pyridone derivatives containing various functional groups.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China. bqwang@nankai.edu.cn.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China. bqwang@nankai.edu.cn.
authors.forename: Ke
authors.initials: K
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China. bqwang@nankai.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, P. R. China.
authors.forename: Baiquan
authors.initials: B
authors.lastname: Wang