title: Asymptomatic Bacteriuria in Noncatheterized Adults.
abstract: Asymptomatic bacteriuria (ASB) is a common finding and frequently detected in premenopausal nonpregnant women, institutionalized patients, patients with diabetes mellitus, and the ambulatory elderly population. Despite clear recommendations regarding diagnosis and management of ASB in these populations from the Infectious Diseases Society of America (IDSA), there remains an alarming rate of antimicrobial overuse. This article reviews definitions of ASB, epidemiology of ASB, literature surrounding ASB in diabetic patients, risk factors of ASB, microbiologic data regarding bacterial virulence, use of ASB strains for treatment of symptomatic urinary tract infection, and approaches to addressing translational barriers to implementing IDSA recommendations regarding diagnosis and management of ASB.
authors.affiliation: Department of Urology, University of Pittsburgh Medical Center, 300 Halket Street, Suite 4710, Pittsburgh, PA 15213, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Ferroni
authors.affiliation: Department of Urology, University of Pittsburgh Medical Center, 300 Halket Street, Suite 4710, Pittsburgh, PA 15213, USA. Electronic address: taylora10@upmc.edu.
authors.forename: Aisha Khalali
authors.initials: AK
authors.lastname: Taylor
mesh_terms: D000328:Adult; D058345:Asymptomatic Infections / Q000453:epidemiology; D001427:Bacterial Toxins / Q000378:metabolism; D001437:Bacteriuria / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy*; D001691:Biological Therapy; D048909:Diabetes Complications / Q000453:epidemiology; D004926:Escherichia coli / Q000378:metabolism; D004927:Escherichia coli Infections / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism; D005260:Female; D010861:Fimbriae, Bacterial / Q000378:metabolism; D006460:Hemolysin Proteins / Q000378:metabolism; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism; D008297:Male; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D037521:Virulence Factors
chemical_list: D001427:Bacterial Toxins; D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins; D008070:Lipopolysaccharides; D037521:Virulence Factors; C060296:cytotoxic necrotizing factor type 1
keywords: Antimicrobial overtreatment; Asymptomatic bacteriuria; IDSA; Live biotherapeutics; Translational barriers; Urinary tract infection