title: Natural History, Prognosis, and Socioeconomic Aspects of Psoriatic Arthritis.
abstract: Although early reports suggested psoriatic arthritis was, with the exception of arthritis mutilans, a relatively mild arthritis, later studies have challenged this view. The burden of skin disease adds to disability and impaired quality of life. Patients in secondary care manifest increased morbidity and mortality, mainly owing to cardiovascular disease. A subset of patients, primarily men with oligoarticular disease, demonstrates low levels of joint involvement without disability. The socioeconomic impact of the disease is significant. We require more information on the impact of early diagnosis and treatment on outcome, according to phenotype, to guide policy.
authors.affiliation: Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, University of Leeds, 2nd Floor, Harehills Lane, Leeds LS7 4SA, UK.
authors.forename: Philip S
authors.initials: PS
authors.lastname: Helliwell
authors.affiliation: Division of Rheumatology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611, USA. Electronic address: p.helliwell@leeds.ac.uk.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Ruderman
mesh_terms: D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000191:economics / Q000209:etiology; D018450:Disease Progression; D042241:Early Diagnosis; D006801:Humans; D011379:Prognosis; D011788:Quality of Life; D012959:Socioeconomic Factors
keywords: Comorbidities; Disability; Natural history; Prognosis; Psoriasis; Psoriatic arthritis; Quality of life; Work