title: Hopping Pits Catch Fusing Granules.
abstract: In excitable cells, regulated exocytosis is coupled to endocytic membrane retrieval. Yuan et al. (2015) in this issue of Developmental Cell report a possible mechanism for such exo-endocytic coupling that is based on stimulation-induced hopping of clathrin-containing endocytic structures to nascent sites of insulin granule fusion.
authors.affiliation: Leibniz Institut für Molekulare Pharmakologie (FMP), Robert-Roessle-Straße 10, 13125 Berlin, Germany. Electronic address: haucke@fmp-berlin.de.
authors.forename: Volker
authors.initials: V
authors.lastname: Haucke
mesh_terms: D000818:Animals; D002966:Clathrin / Q000378:metabolism*; D003034:Coated Pits, Cell-Membrane / Q000502:physiology*; D004075:Diglycerides / Q000378:metabolism*; D005089:Exocytosis / Q000502:physiology*; D007340:Insulinoma / Q000378:metabolism*; D008870:Microtubules / Q000502:physiology*; D010190:Pancreatic Neoplasms / Q000378:metabolism*
chemical_list: D002966:Clathrin; D004075:Diglycerides