title: Effects of 3-h hypothermia after neonatal hyperthermic hypoxic-ischemic encephalopathy in rat models on behavioral prognosis and anatomical and histological features after growth.
abstract: OBJECTIVE
  To clarify the effects of 3-h hypothermia on learning ability and motor function after growth, employing neonatal rat models with hyperthermic hypoxic-ischemic encephalopathy (HIE).
  
  
  METHODS
  We divided all rats into three groups: N (adult rats after neonatal hyperthermic HIE without subsequent 3-h hypothermia), H (adult rats after neonatal hyperthermic HIE with subsequent 3-h hypothermia) and Sham (S) groups. We evaluated their malfunctions with the rota-rod test and the step-down passive avoidance test. We also analyzed the cerebrum width and the hippocampal CA1 area of the insulted hemisphere.
  
  
  RESULTS
  In the rota-rod test, the result of the N group was significantly worse than that of the S group. In the step-down passive avoidance test, the result of the N group was significantly worse than those of the S and H groups. The longest cerebrum width and the hippocampal CA1 area of the insulted hemisphere of the N group were significantly smaller than those of the S and H groups.
  
  
  CONCLUSIONS
  Neonatal hyperthermic hypoxic-ischemic insult restricts motor function and learning ability after growth, and such neuronal malfunctions can be relieved by hypothermia for 3 h soon after neonatal HIE.
authors.affiliation: a Department of Biomedical Engineering , Graduate School of Osaka Electro-Communication University , Osaka , Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Nishimura
authors.affiliation: a Department of Biomedical Engineering , Graduate School of Osaka Electro-Communication University , Osaka , Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Hosono
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning; D056547:CA1 Region, Hippocampal / Q000473:pathology; D004195:Disease Models, Animal; D006128:Growth; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology / Q000523:psychology / Q000628:therapy*; D007858:Learning; D009043:Motor Activity; D017208:Rats, Wistar; D045442:Rotarod Performance Test
keywords: Hyperthermia; hypothermia; neonatal hypoxic-ischemic encephalopathy; rota-rod test; step-down passive avoidance test