title: Bioavailabilty of a liquid Vitamin Trace Element Composition in healthy volunteers.
abstract: BACKGROUND
  Many Vitamins and minerals for dietary supplements lack a standard scientific and regulatory definition that accurately reflects the bioavailabilities in humans. Especially the bioavailability of natural compounds in complex mixtures, where the different ingredients may interfere with each other, is unknown.
  
  
  METHODS
  To learn more about the bioavailability of the ingredients in the complex compound LaVita® we examined blood levels of subjects, who ingested the multivitamin and trace element composition for 6 month continuously. Blood samples for the analysis of the ingredients were taken before, during, and after administration.
  
  
  RESULTS
  Our data indicated a significant increase of most ingredients after 3 month, and additional three months, except for Vitamin (B9 Folic acid). The semivitamins Q10 and carnitine increased in the first 3 month (both p<0.001). While carnitine dropped during the second term, Q10 levels increased further slowly. After three months a significant increase was observed for iron (serum p=0.039; blood cells p=0.025), Selenium (serum p=0.048; cells p=0.006), and chromium (serum p=0.029). Zinc - known to interfere with the iron resorption - increased slowly in the first term of 3 months, but was raised significantly after 6 months (serum and blood cells, each p<0.001). The Copper/Zink ratio dropped accordingly (p<0.001).
  
  
  CONCLUSIONS
  We conclude that resorption interference between specific ingredients, and after resorption redistribution of specific ingredients to various tissue compartments precludes a linear increase of the respective serum parameters. We observed no deleterious resorption competitions for individual compounds. No parameter reached critical levels. We conclude that the test substance (LaVita®) is a sufficiently safe composite for long term consumption.
authors.affiliation: Internationale Gesellschaft für angewandte Präventionsmedizin I-GAP, Wien, Austria.
authors.forename: Claus
authors.initials: C
authors.lastname: Muss
authors.affiliation: Inst. f. Krebsforschung, KIM-1, Medizinische Universität, Wien, Austria.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Mosgoeller
authors.affiliation: Labor Endler, Wien, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Endler
mesh_terms: D000328:Adult; D001682:Biological Availability; D002331:Carnitine / Q000493:pharmacokinetics; D002857:Chromium / Q000493:pharmacokinetics; D019587:Dietary Supplements / Q000592:standards*; D005260:Female; D005492:Folic Acid / Q000493:pharmacokinetics; D064368:Healthy Volunteers; D006801:Humans; D007501:Iron / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D014131:Trace Elements / Q000097:blood / Q000493:pharmacokinetics*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D014815:Vitamins / Q000097:blood / Q000493:pharmacokinetics*; D015032:Zinc / Q000493:pharmacokinetics
chemical_list: D014131:Trace Elements; D014815:Vitamins; D002857:Chromium; D014451:Ubiquinone; D005492:Folic Acid; D007501:Iron; C024989:coenzyme Q10; D015032:Zinc; D002331:Carnitine