title: Biomimetic composite microspheres of collagen/chitosan/nano-hydroxyapatite: In-situ synthesis and characterization.
abstract: The collagen/chitosan/hydroxyapatite (COL/CS/HA) composite microspheres with a good spherical form and a high dispersity were successfully obtained using an in-situ synthesis method. The FT-IR and XRD results revealed that the inorganic phase in the microspheres was crystalline HA containing carbonate ions. The morphology of the composite microspheres was dependent on the HA content, and a more desirable morphology was achieved when 20 wt.% HA was contained. The composite microspheres exhibited a narrow particle distribution, most of which ranged from 5 to 10 μm. In addition, the needle-like HA nano-particles were uniformly distributed in the composite microspheres, and their crystallinity and crystal size decreased with the HA content.
authors.affiliation: School of Materials Science and Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116, China. Electronic address: shteng425@cumt.edu.cn.
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Teng
authors.affiliation: School of Materials Science and Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116, China.
authors.forename: Mian-Hui
authors.initials: MH
authors.lastname: Liang
authors.affiliation: School of Materials Science and Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size
chemical_list: D001672:Biocompatible Materials; D003094:Collagen; D048271:Chitosan; D017886:Durapatite
keywords: Biomaterials; Composite; In-situ synthesis; Microspheres; Microstructure