title: Mini-review: Retarding aging in murine genetic models of neurodegeneration.
abstract: Retardation of aging processes is a plausible approach to delaying the onset or slowing the progression of common neurodegenerative disorders. We review the results of experiments using murine genetic models of Alzheimer disease and Huntington disease to evaluate the effects of retarding aging. While positive results are reported in several of these experiments, there are several discrepancies in behavioral and pathologic outcomes both within and between different experiments. Similarly, different experiments yield varying assessments of potential proximate mechanisms of action of retarding aging. The anti-aging interventions used for some experiments include some that show only modest effects on lifespan, and others that have proven hard to reproduce. Several experiments used aggressive transgenic neurodegenerative disease models that may be less relevant in the context of age-related diseases. The experience with these models and interventions may be useful in designing future experiments assessing anti-aging interventions for disease-modifying treatment of neurodegenerative diseases.
authors.affiliation: Neurology Service & GRECC, VAAAHS, Ann Arbor, MI 48105, USA; Dept. of Neurology, University of Michigan, Ann Arbor, MI 48109, USA; University of Michigan Udall Center for Parkinson's Disease Research, Ann Arbor, MI 48109, USA; Michigan Alzheimer Disease Center, Ann Arbor, MI 48109, USA. Electronic address: ralbin@umich.edu.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Albin
authors.affiliation: Dept. of Pathology & Geriatrics Center, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Miller
mesh_terms: D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D004195:Disease Models, Animal; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy*
keywords: Aging; Alzheimer disease; Amyloid; Huntington disease; Neurodegeneration; Polyglutamine; Senescence