title: Urinary Tract Infection and Neurogenic Bladder.
abstract: Urinary tract infections (UTIs) are frequent, recurrent, and lifelong for patients with neurogenic bladder and present challenges in diagnosis and treatment. Patients often present without classic symptoms of UTI but with abdominal or back pain, increased spasticity, and urinary incontinence. Failure to recognize and treat infections can quickly lead to life-threatening autonomic dysreflexia or sepsis, whereas overtreatment contributes to antibiotic resistance, thus limiting future treatment options. Multiple prevention methods are used but evidence-based practices are few. Prevention and treatment of symptomatic UTI requires a multimodal approach that focuses on bladder management as well as accurate diagnosis and appropriate antibiotic treatment.
authors.affiliation: Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Maxim J
authors.initials: MJ
authors.lastname: McKibben
authors.affiliation: Division of Infectious Disease, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Seed
authors.affiliation: Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Sherry S
authors.initials: SS
authors.lastname: Ross
authors.affiliation: Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: Kristy_borawski@med.unc.edu.
authors.forename: Kristy M
authors.initials: KM
authors.lastname: Borawski
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D055499:Catheter-Related Infections / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D057928:Intermittent Urethral Catheterization / Q000009:adverse effects; D008358:Mannose / Q000627:therapeutic use; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use; D019936:Probiotics / Q000627:therapeutic use; D007507:Therapeutic Irrigation; D001743:Urinary Bladder / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000150:complications* / Q000628:therapy; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D029799:Vaccinium macrocarpon
chemical_list: D000900:Anti-Bacterial Agents; D028321:Plant Preparations; D008358:Mannose
keywords: Antibiotic prophylaxis; Antimicrobial resistance; Bacterial interference; Neurogenic bladder; Probiotics; Spina bifida; Spinal cord injury; Urinary tract infection