title: Invited Review: Polycomb group genes in the regeneration of the healthy and pathological skeletal muscle.
abstract: The polycomb group (PcG) proteins are epigenetic repressors required during key developmental processes, such as maintenance of cell identity and stem cell differentiation. To exert their repressive function, PcG proteins assemble on chromatin into multiprotein complexes, known as polycomb repressive complex 1 and 2. In this review, we will focus on the role and mode of function of PcG proteins in the development and regeneration of the skeletal muscle, both in normal and pathological conditions and we will discuss the emerging concept of modulation of their expression to enhance the muscle-specific regenerative process for patient benefit.
authors.affiliation: Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Marino
authors.affiliation: Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
authors.forename: V
authors.initials: V
authors.lastname: Di Foggia
mesh_terms: D000818:Animals; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology*; D063146:Polycomb-Group Proteins / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*
chemical_list: D063146:Polycomb-Group Proteins
keywords: Duchenne muscular dystrophy; muscle homeostasis; muscle regeneration; neuromuscular disorders; polycomb group genes; satellite cells