title: Effect of submucosal application of tramadol on postoperative pain after third molar surgery.
abstract: The aim of this study was to evaluate the effectiveness of submucosal application of tramadol, for acute postoperative facial pain, following the extraction of impacted third molar teeth. This prospective, double-blind, randomised placebo-controlled study included 60 ASA I-II patients undergoing impacted third molar surgery under local anaesthesia. Following the surgical procedure, patients were randomly divided into two groups; group T (1 mg/kg tramadol) and group S (2-mL saline). Treatments were applied submucosally after surgery. Pain after extraction was evaluated using a visual analogue scale (VAS) 0.5, 1, 2, 4, 6, 12, 24, and 48 h postoperatively. The time at which the first analgesic drug was taken, the total analgesic dose used, and adverse tissue reactions were also evaluated. In group T, postoperative VAS scores were significantly lower compared to that in group S (p < 0.05). This study demonstrated that post-operative submucosal application of tramadol is an effective method for reducing acute post-operative facial pain after impacted third molar surgery.
authors.affiliation: Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Marmara University, Istanbul, Turkey. onurgonul@marmara.edu.tr.
authors.forename: Onur
authors.initials: O
authors.lastname: Gönül
authors.affiliation: Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Marmara University, Istanbul, Turkey.
authors.forename: Tülin
authors.initials: T
authors.lastname: Satılmış
authors.affiliation: Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Marmara University, Istanbul, Turkey.
authors.forename: Ferit
authors.initials: F
authors.lastname: Bayram
authors.affiliation: Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Marmara University, Istanbul, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Göçmen
authors.affiliation: Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Marmara University, Istanbul, Turkey.
authors.forename: Aysegül
authors.initials: A
authors.lastname: Sipahi
authors.affiliation: Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Marmara University, Istanbul, Turkey.
authors.forename: Kamil
authors.initials: K
authors.lastname: Göker
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D014081:Tooth Extraction / Q000009:adverse effects*; D014095:Tooth, Impacted / Q000601:surgery; D014147:Tramadol / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol