title: Relating Intercellular Variability in Nanoparticle Uptake with Biological Consequence: A Quantitative X-ray Fluorescence Study for Radiosensitization of Cells.
abstract: Internalized gold nanoparticles were quantified in large numbers of individual prostate cancer cells using large area synchrotron X-ray fluorescence microscopy. Cells were also irradiated with a 6 MV linear accelerator to assess the biological consequence of radiosensitization with gold nanoparticles. A large degree of heterogeneity in nanoparticle uptake between cells resulted in influenced biological effect.
authors.affiliation: Future Industries Institute, University of South Australia , Mawson Lakes Campus, Mawson Lakes, Adelaide, South Australia 5095, Australia.
authors.forename: Tyron
authors.initials: T
authors.lastname: Turnbull
authors.affiliation: Department of Medical Physics, Royal Adelaide Hospital , North Terrace, Adelaide, South Australia 5000, Australia.|School of Physical Sciences, University of Adelaide , North Terrace, Adelaide, South Australia 5005, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Douglass
authors.affiliation: Australian Synchrotron , Clayton, Victoria 3168, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Paterson
authors.affiliation: School of Physical Sciences, University of Adelaide , North Terrace, Adelaide, South Australia 5005, Australia.|International Centre for Allied Health Evidence and Sansom Institute for Health Research, Division of Health Sciences, University of South Australia , Adelaide, South Australia 5001, Australia.
authors.forename: Eva
authors.initials: E
authors.lastname: Bezak
authors.affiliation: Future Industries Institute, University of South Australia , Mawson Lakes Campus, Mawson Lakes, Adelaide, South Australia 5095, Australia.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Thierry
authors.affiliation: Future Industries Institute, University of South Australia , Mawson Lakes Campus, Mawson Lakes, Adelaide, South Australia 5095, Australia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Kempson
mesh_terms: D002477:Cells / Q000187:drug effects / Q000528:radiation effects*; D005453:Fluorescence; D006046:Gold / Q000737:chemistry; D006801:Humans; D008027:Light; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D011471:Prostatic Neoplasms / Q000188:drug therapy; D014965:X-Rays
chemical_list: D006046:Gold