title: Characterization of naproxen-polymer conjugates for drug-delivery.
abstract: The synthesis and the characterization of three new naproxen decorated polymers are described. A versatile and general approach is employed to link the drug to polymers, affording the derivatives with a very high degree of purity. The release of the drug from the conjugates proved to be exceptionally slow, even in acidic aqueous media, and the kinetic of the process seems to be triggered by their solubility in water. On the other hand, the interesting outcome of the first ex vivo drug release experiments on human blood samples makes this preliminary study valuable for future investigations on the use of these polymeric prodrugs in in vivo treatment of inflammatory states.
authors.affiliation: a Dipartimento di Scienze di Base e Applicate per l'Ingegneria , Sapienza Università di Roma , Roma , Italy.
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Forte
authors.affiliation: a Dipartimento di Scienze di Base e Applicate per l'Ingegneria , Sapienza Università di Roma , Roma , Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Chiarotto
authors.affiliation: b Dipartimento di Chimica , Sapienza Università di Roma , Roma , Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Giannicchi
authors.affiliation: b Dipartimento di Chimica , Sapienza Università di Roma , Roma , Italy.
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Loreto
authors.affiliation: b Dipartimento di Chimica , Sapienza Università di Roma , Roma , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Martinelli
authors.affiliation: b Dipartimento di Chimica , Sapienza Università di Roma , Roma , Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Micci
authors.affiliation: c Dipartimento di Chimica e Tecnologie del Farmaco , Sapienza Università di Roma , Roma , Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Pepi
authors.affiliation: b Dipartimento di Chimica , Sapienza Università di Roma , Roma , Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Rossi
authors.affiliation: c Dipartimento di Chimica e Tecnologie del Farmaco , Sapienza Università di Roma , Roma , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Salvitti
authors.affiliation: d Dipartimento di Tecnologia e Salute , Istituto Superiore di Sanità , Roma , Italy.
authors.forename: Annarita
authors.initials: A
authors.lastname: Stringaro
authors.affiliation: e Laboratorio di Analisi di Superfici, Dipartimento di Matematica e Fisica and INFN , Università Roma Tre , Roma , Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Tortora
authors.affiliation: a Dipartimento di Scienze di Base e Applicate per l'Ingegneria , Sapienza Università di Roma , Roma , Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Vecchio Ciprioti
authors.affiliation: a Dipartimento di Scienze di Base e Applicate per l'Ingegneria , Sapienza Università di Roma , Roma , Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Feroci
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D004355:Drug Stability; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D009288:Naproxen / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry*; D012995:Solubility; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014867:Water / Q000737:chemistry
chemical_list: D011108:Polymers; D011355:Prodrugs; D014867:Water; D009288:Naproxen
keywords: Drug delivery; NSAID; PEGylation; drug–polymer conjugates; naproxen; polypyrrole