title: Incidence of epithelial ovarian cancer according to histologic subtypes in Korea, 1999 to 2012.
abstract: OBJECTIVE
  To investigate trends in the incidence of epithelial ovarian cancer (EOC), according to histologic subtypes, in Korean women between 1999 and 2012.
  
  
  METHODS
  Data from the Korea Central Cancer Registry recorded between 1999 and 2012 were evaluated. The incidences of EOC histologic subtypes were counted. Age-standardized incidence rates (ASRs) and annual percentage changes (APCs) in incidence rates were calculated. Patient data were divided into three groups based on age (<40, 40 to 59, and >59 years), and age-specific incidence rates were compared.
  
  
  RESULTS
  Overall, the incidence of EOC has increased. Annual EOC cases increased from 922 in 1999 to 1,775 in 2012. In 1999, the ASR was 3.52 per 100,000 and increased to 4.79 per 100,000 in 2012 (APC, 2.53%; p<0.001). The ASRs in 2012 and APCs between 1999 and 2012 for the four major histologic subtypes were as follows (in order of incidence): serous carcinoma (ASR, 2.32 per 100,000; APC, 4.34%; p<0.001), mucinous carcinoma (ASR, 0.73 per 100,000; APC, -1.05%; p=0.131), endometrioid carcinoma (ASR, 0.51 per 100,000; APC, 1.48%; p=0.032), and clear cell carcinoma (ASR, 0.50 per 100,000; APC, 8.13%; p<0.001). In the sub-analyses based on age, clear cell carcinoma was confirmed as the histologic subtype whose incidence had increased the most since 1999.
  
  
  CONCLUSIONS
  The incidence of EOC is increasing in Korea. Among the histologic subtypes, the incidence of clear cell carcinoma has increased markedly across all age groups since 1999.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Se Ik
authors.identifier: http://orcid.org/0000-0002-9790-6735
authors.initials: SI
authors.lastname: Kim
authors.affiliation: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.|Gynecologic Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea.|Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
authors.forename: Myong Cheol
authors.identifier: http://orcid.org/0000-0001-8964-7158
authors.initials: MC
authors.lastname: Lim
authors.affiliation: Cancer Registration and Statistics Branch, National Cancer Control Institute, National Cancer Center, Goyang, Korea.
authors.forename: Jiwon
authors.identifier: http://orcid.org/0000-0002-3322-7792
authors.initials: J
authors.lastname: Lim
authors.affiliation: Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.|Cancer Registration and Statistics Branch, National Cancer Control Institute, National Cancer Center, Goyang, Korea.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Won
authors.affiliation: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Seo
authors.affiliation: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.|Gynecologic Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea.|Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
authors.forename: Sokbom
authors.identifier: http://orcid.org/0000-0002-8428-9555
authors.initials: S
authors.lastname: Kang
authors.affiliation: Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.|Gynecologic Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea. parksang@ncc.re.kr.
authors.forename: Sang Yoon
authors.identifier: http://orcid.org/0000-0001-8325-6009
authors.initials: SY
authors.lastname: Park
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000453:epidemiology / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000473:pathology; D000328:Adult; D017677:Age Distribution; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000453:epidemiology / Q000473:pathology; D000077216:Carcinoma, Ovarian Epithelial; D018284:Cystadenocarcinoma, Serous / Q000453:epidemiology / Q000473:pathology; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000473:pathology; D012042:Registries; D056910:Republic of Korea / Q000453:epidemiology
keywords: Histologic Subtype; Incidence; Ovarian Neoplasms; Time Trends