title: Factors for Endoscopic Submucosal Dissection in Early Colorectal Neoplasms: A Single Center Clinical Experience in China.
abstract: OBJECTIVE
  Early colorectal (CR) neoplasm can be cured by endoscopic submucosal dissection (ESD), but clinical experience and factors associated with complications from ESD for CR neoplasms in China have not been reported.
  
  
  METHODS
  Seventy-eight cases of early CR neoplasm treated with endoscopic resection performed between December 2012 and December 2013 at Beijing Military General Hospital were included. Factors associated with ESD complications and procedure times were evaluated.
  
  
  RESULTS
  The en bloc resection rate was 88.5% (69/78), tumor size was 32.1±10.7 mm, and procedure time was 71.8±49.5 minutes. The major complication was perforation, which occurred in 8.97% of the ESD procedures. Multivariate logistic regression analysis indicated that only tumor size (p=0.022) was associated with ESD perforation. Tumor size (p<0.001) and the non-lifting sign (p=0.017) were independent factors for procedure time, and procedure time (p=0.016) was a key factor for en bloc resection. After a median 10 months (range, 4 to 16) of follow-up, no patients had local recurrence.
  
  
  CONCLUSIONS
  This study indicated that ESD is an applicable method for large early CR neoplasm in the colon and rectum. Tumor size and the non-lifting sign might be considerable factors for increased complication rate and procedural time of ESD.
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing, China.
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: He
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing, China.
authors.forename: Ai-Qin
authors.initials: AQ
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing, China.
authors.forename: Lang
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Kang
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Tang
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Jin
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing, China.
authors.forename: Jian-Qiu
authors.initials: JQ
authors.lastname: Sheng
keywords: Complications; Early colorectal neoplasms; Endoscopic submucosal dissection; Procedure time