title: Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery.
abstract: Experience-dependent plasticity is limited in the adult brain, and its molecular and cellular mechanisms are poorly understood. Removal of the myelin-inhibiting signaling protein, Nogo receptor (NgR1), restores adult neural plasticity. Here we found that, in NgR1-deficient mice, whisker experience-driven synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) insertion in the barrel cortex, which is normally complete by 2 weeks after birth, lasts into adulthood. In vivo live imaging by two-photon microscopy revealed more AMPAR on the surface of spines in the adult barrel cortex of NgR1-deficient than on those of wild-type (WT) mice. Furthermore, we observed that whisker stimulation produced new spines in the adult barrel cortex of mutant but not WT mice, and that the newly synthesized spines contained surface AMPAR. These results suggest that Nogo signaling limits plasticity by restricting synaptic AMPAR delivery in coordination with anatomical plasticity.
authors.affiliation: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Jitsuki
authors.affiliation: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Waki
authors.initials: W
authors.lastname: Nakajima
authors.affiliation: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.|JST, PRESTO, Saitama 332-0012, Japan.
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Takemoto
authors.affiliation: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Akane
authors.initials: A
authors.lastname: Sano
authors.affiliation: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Hirobumi
authors.initials: H
authors.lastname: Tada
authors.affiliation: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Aoi
authors.initials: A
authors.lastname: Takahashi-Jitsuki
authors.affiliation: Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology*; D049229:Dendritic Spines / Q000502:physiology*; D008822:Mice, Transgenic; D009185:Myelin Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D018091:Receptors, AMPA / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D014738:Vibrissae / Q000502:physiology
chemical_list: D009185:Myelin Proteins; D018091:Receptors, AMPA