title: Expression of PGAM1 in renal clear cell carcinoma and its clinical significance.
abstract: OBJECTIVE
  This study is aimed to evaluate the expression of phosphoglycerate mutase 1 (PGAM1) in normal kidney and clear cell renal cell carcinoma (CCRCC), also to evaluate the correlation between PGAM1 expression and clinicopathological features in CCRCC.
  
  
  METHODS
  PGAM1 expression was detected in 80 cases of normal kidney and 192 cases of CCRCC by immunohistochemistry (IHC). Meanwhile, PGAM1 expression measured in 8 cases of CCRCC and matched normal kidney tissues by Western blot. Then, the correlation between PGAM1 expression and clinicalpathological features was analyzed in CCRCC.
  
  
  RESULTS
  IHC results exhibited that the high-expression rate of PGAM1 in CCRCC tissues was 45.8%, which was significantly higher than those in normal kidney tissues (32.5%, P=0.044). Meanwhile, PGAM1 expression in CCRCC was significantly greater compared with those in normal kidney by Western blot. Moreover, PGAM1 expression was significantly associated with age, tumor size and T stage in CCRCC.
  
  
  CONCLUSIONS
  PGAM1 is highly expressed in CCRCC and correlated with clinicalpathological features, which may contribute to tumor formation and progression.
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong Province, China ; Department of Surgery, Women and Children's Hospital of Foshan Foshan, Guangdong, Province, China.
authors.forename: Chunjing
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong Province, China.
authors.forename: Fangpeng
authors.initials: F
authors.lastname: Shu
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Lei
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong Province, China.
authors.forename: Daojun
authors.initials: D
authors.lastname: Lv
authors.affiliation: Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Guangdong Armed Police Hospital, Guangzhou Medical University Guangzhou, Guangdong Province, China.
authors.forename: Shoubo
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong Province, China ; Department of Urology, Peking University Shenzhen Hospital, Shenzhen Pku-Hkust Medical Center Shenzhen, Guangdong Province, China.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Mao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010736:Phosphoglycerate Mutase / Q000378:metabolism*; D011379:Prognosis
chemical_list: D010736:Phosphoglycerate Mutase
keywords: Clear cell renal cell carcinoma; IHC; PGAM1; clinicalpathological features; molecular marker