title: Chronic Serous Macular Detachments and Visual Disturbance Complicating Consecutive Cases of Symptomatic Vitreomacular Adhesion With Macular Hole Treated With Ocriplasmin.
abstract: Two consecutive cases of symptomatic vitreomacular adhesion with macular hole were treated with intravitreal ocriplasmin. Both were complicated by long-term visual symptoms and chronic serous foveal detachments lasting 17 months post-treatment. These findings suggest direct and long-lasting effects of ocriplasmin on the retinal pigment epithelium and/or outer retina. Patients treated with ocriplasmin should be cautioned that the side effects of even successful drug treatment may prolong visual recovery compared to vitrectomy.
authors.forename: Jeffrey K
authors.initials: JK
authors.lastname: Luttrull
mesh_terms: D000368:Aged; D002908:Chronic Disease; D005341:Fibrinolysin / Q000009:adverse effects* / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000009:adverse effects* / Q000627:therapeutic use; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy*; D012167:Retinal Perforations / Q000175:diagnosis / Q000188:drug therapy*; D058471:Subretinal Fluid; D000267:Tissue Adhesions / Q000175:diagnosis / Q000188:drug therapy; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology*; D014792:Visual Acuity; D014822:Vitreous Body / Q000187:drug effects*
chemical_list: D005343:Fibrinolytic Agents; D010446:Peptide Fragments; C054561:microplasmin; D005341:Fibrinolysin