title: [Clinicopathological implications of single positive core prostate cancer in a 12-core transrectal biopsy scheme].
abstract: OBJECTIVE
  To explore the clinicopathological implications of single positive core prostate cancer.
  
  
  METHODS
  A total of 45 patients with transrectal ultrasound (TRUS)-guided prostate biopsy were diagnosed with single positive core prostate cancer and subsequently underwent radical prostatectomy (RP). Their clinicopathological parameters were examined to identify the factors for disease upgrading or upstaging.
  
  
  RESULTS
  On final pathology, only 31.1% patients had unilateral prostate cancer. And 37.8% patients experienced Gleason score upgrading, 66.7% patients had upstaging and 31.1% were found positive surgical margins. On multivariable analyses, the percentage of positive cores was an independent predictor of stage upgrading and perineural invasion at RP pathology. Age, prostate volume and preoperative prostate-specific antigen/prostate-specific antigen density (PSA/PSAD) had no significant effect on underestimated tumor burden.
  
  
  CONCLUSIONS
  Most single positive core prostate cancer diagnosed by 12-core biopsy may be underestimated. The percentage of positive cores is an independent predictor of underestimated prostate cancer. Currently we have no instruments for accurately identifying microfocal or unilateral prostate cancer.
authors.affiliation: Department of Urology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Mingxin
authors.initials: M
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaogong
authors.initials: X
authors.lastname: Li
authors.forename: Yifen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Email: dr.ghq@163.com.
authors.forename: Hongqian
authors.initials: H
authors.lastname: Guo
mesh_terms: D001706:Biopsy; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D017430:Prostate-Specific Antigen; D011468:Prostatectomy; D011471:Prostatic Neoplasms; D047368:Tumor Burden
chemical_list: D017430:Prostate-Specific Antigen