title: [Effect of Risperidone on BDNF-TrkB Signaling Pathway in Rat Brain].
abstract: OBJECTIVE
  To investigate the effect of risperidone on the expression of brain-derived neurotrophic factor (BDNF) and its receptors, tyrosine kinase receptor (TrkB) and P75 neurotrophin receptor (P75NTR) in rat brain.
  
  
  METHODS
  Sixteen SD rats were divided into two groups (n = 8 for each group). The rats in experimental group were treated with risperidone [0.25 mg/(kg · d)] for 14 d, while the control group was given placebo. Total RNA sample in prefrontal cortex, temporal cortex and hippocampus was extracted, and the expression of BDNF, TrkB and P75NTR mRNA were determined by quantitative real-time PCR.
  
  
  RESULTS
  The treatment of risperidone significantly up-regulated the expressions of BDNF and TrkB in prefrontal cortex, temporal cortex and hippocampus, while the expression of P75NTR was not significantly changed.
  
  
  CONCLUSIONS
  Risperidone upregulated BDNF-TrkB signaling, but not BDNF-P75NTR signaling, which may be helpful for the further pharmacological study of risperidone.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.forename: Jin-xue
authors.initials: JX
authors.lastname: Wei
authors.forename: Pei-yan
authors.initials: PY
authors.lastname: Ni
authors.forename: Lin-hui
authors.initials: LH
authors.lastname: Liang
authors.forename: Lian-sheng
authors.initials: LS
authors.lastname: Zhao
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Ma
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Ying-cheng
authors.initials: YC
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D006624:Hippocampus; D009419:Nerve Tissue Proteins; D017397:Prefrontal Cortex; D012333:RNA, Messenger; D051381:Rats; D017207:Rats, Sprague-Dawley; D020813:Receptor, trkB / Q000378:metabolism*; D017978:Receptors, Growth Factor; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism; D018967:Risperidone / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D013702:Temporal Lobe
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D017978:Receptors, Growth Factor; D017475:Receptors, Nerve Growth Factor; C068313:Ngfr protein, rat; D020813:Receptor, trkB; D018967:Risperidone