title: The Protective Effects of Epigallocatechin Gallate Against Distant Organ Damage After Severe Skin Burns--Experimental Study Using a Rat Model of Thermal Trauma.
abstract: BACKGROUND
  Epigallocatechin gallate (EGCG), a green tea polyphenol, has potent antioxidant properties.
  
  
  OBJECTIVE
  The purpose of the present study was to examine the possible preventative effects of EGCG against internal organ injury due to large-surface skin burns in a rat model.
  
  
  METHODS
  The study design involved three groups of rats: a sham group and two groups with 25-30% full-thickness burns: (a) the sham group without burns or treatment (n=18); (b) the control burn group (burns+sterile saline, n=18); and (c) the burn treatment group (burns+treatment with EGCG, n=18). EGCG was administered intraperitoneally immediately after the thermal injury, and daily in 100 μmol/kg doses. Kidney and lung tissue samples were taken to determine the levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), and glutathione peroxidase (GPX) after the first, third and seventh post-burn days.
  
  
  RESULTS
  In the EGCG-treated burn group, SOD and GPX activity were significantly higher than in the burn control group. Additionally, MDA and TNF-α levels were significantly lower in the EGCG-treated burn group.
  
  
  CONCLUSIONS
  Based on this study, it might be anticipated that EGCG treatment may be beneficial in burn injury cases.
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Katip Celebi University School of Medicine, Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Mubin
authors.initials: M
authors.lastname: Hosnuter
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Sifa University School of Medicine, Izmir, Turkey.
authors.forename: Cenk
authors.initials: C
authors.lastname: Melikoglu
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Katip Celebi University School of Medicine, Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Aslan
authors.affiliation: Department of Biochemistry, Katip Celebi University School of Medicine, Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Gulcan
authors.initials: G
authors.lastname: Saglam
authors.affiliation: Department of Biochemistry, Katip Celebi University School of Medicine, Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Sutcu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002056:Burns / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004195:Disease Models, Animal; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007674:Kidney Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D055370:Lung Injury / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008315:Malondialdehyde / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D017208:Rats, Wistar; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D002392:Catechin; C045651:epigallocatechin gallate; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase