title: [Metabolic regulation of stem cells].
abstract: Stem cells activate various metabolic programs and acquire ATP and metabolites to maintain self-renewal and multi-differentiation capacities. Pluripotent stem cells and hematopoietic stem cells have recently been shown to have specific metabolic features different from those of differentiated cells. These metabolic features themselves drive stem cell-specific characteristics. Thus, integrative understandings of metabolic regulation of stem cells are essential for the development of technologies for ex vivo expansion of stem cells, efficient induction of differentiated cells from stem cells and targeted therapies aimed at controlling and eliminating tumor-initiating cells.
authors.affiliation: Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine.
authors.forename: Keiyo
authors.initials: K
authors.lastname: Takubo
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D006019:Glycolysis; D006801:Humans; D055432:Metabolomics; D010427:Pentose Phosphate Pathway; D013234:Stem Cells / Q000378:metabolism*