title: Biomarkers of Nutrition for Development-Folate Review.
abstract: The Biomarkers of Nutrition for Development (BOND) project is designed to provide evidence-based advice to anyone with an interest in the role of nutrition in health. Specifically, the BOND program provides state-of-the-art information and service with regard to selection, use, and interpretation of biomarkers of nutrient exposure, status, function, and effect. To accomplish this objective, expert panels are recruited to evaluate the literature and to draft comprehensive reports on the current state of the art with regard to specific nutrient biology and available biomarkers for assessing nutrients in body tissues at the individual and population level. Phase I of the BOND project includes the evaluation of biomarkers for 6 nutrients: iodine, iron, zinc, folate, vitamin A, and vitamin B-12. This review represents the second in the series of reviews and covers all relevant aspects of folate biology and biomarkers. The article is organized to provide the reader with a full appreciation of folate's history as a public health issue, its biology, and an overview of available biomarkers (serum folate, RBC folate, and plasma homocysteine concentrations) and their interpretation across a range of clinical and population-based uses. The article also includes a list of priority research needs for advancing the area of folate biomarkers related to nutritional health status and development.
authors.affiliation: Department of Foods and Nutrition, University of Georgia, Athens, GA; raitend@mail.nih.gov folate@uga.edu.
authors.forename: Lynn B
authors.initials: LB
authors.lastname: Bailey
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, NY;
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Stover
authors.affiliation: Northern Ireland Centre for Food and Health, Biomedical Sciences Research Institute, University of Ulster, Londonderry, United Kingdom;
authors.forename: Helene
authors.initials: H
authors.lastname: McNulty
authors.affiliation: Genome Health Nutrigenomics Laboratory, Food, Nutrition, and Bioproducts Flagship, Commonwealth Scientific and Industrial Research Organization, Adelaide, Australia;
authors.forename: Michael F
authors.initials: MF
authors.lastname: Fenech
authors.affiliation: Food Science and Human Nutrition Department, University of Florida, Gainesville, FL;
authors.forename: Jesse F
authors.initials: JF
authors.lastname: Gregory
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD;
authors.forename: James L
authors.initials: JL
authors.lastname: Mills
authors.affiliation: National Center for Environmental Health, CDC, Atlanta, GA;
authors.forename: Christine M
authors.initials: CM
authors.lastname: Pfeiffer
authors.affiliation: National Center for Environmental Health, CDC, Atlanta, GA;
authors.forename: Zia
authors.initials: Z
authors.lastname: Fazili
authors.affiliation: National Center for Environmental Health, CDC, Atlanta, GA;
authors.forename: Mindy
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Clinical Science, Univeristy of Bergen, Bergen, Norway;
authors.forename: Per M
authors.initials: PM
authors.lastname: Ueland
authors.affiliation: Institute of Molecular Medicine, Trinity College, Dublin, Ireland;
authors.forename: Anne M
authors.initials: AM
authors.lastname: Molloy
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, NY;
authors.forename: Marie A
authors.initials: MA
authors.lastname: Caudill
authors.affiliation: Department of Nutritional Sciences and Toxicology, University of California-Berkeley, Berkeley, CA;
authors.forename: Barry
authors.initials: B
authors.lastname: Shane
authors.affiliation: National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA; and.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Berry
authors.affiliation: Office of Dietary Supplements, NIH, Bethesda, MD.
authors.forename: Regan L
authors.initials: RL
authors.lastname: Bailey
authors.affiliation: Department of Foods and Nutrition, University of Georgia, Athens, GA;
authors.forename: Dorothy B
authors.initials: DB
authors.lastname: Hausman
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD;
authors.forename: Ramkripa
authors.initials: R
authors.lastname: Raghavan
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD; raitend@mail.nih.gov folate@uga.edu.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Raiten
mesh_terms: D015415:Biomarkers / Q000097:blood*; D019587:Dietary Supplements; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D007455:Iodine / Q000097:blood; D007501:Iron / Q000097:blood; D015596:Nutrition Assessment; D009752:Nutritional Status; D064167:Recommended Dietary Allowances; D014801:Vitamin A / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood; D015032:Zinc / Q000097:blood
chemical_list: D015415:Biomarkers; D014801:Vitamin A; D005492:Folic Acid; D007455:Iodine; D007501:Iron; D015032:Zinc; D014805:Vitamin B 12
keywords: BOND; RBC folate; folate biomarkers; homocysteine; serum folate