title: Associations of C1q/TNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans.
abstract: OBJECTIVE
  To investigate the correlation of CTRP9 with coronary atherosclerosis.
  
  
  METHODS
  Coronary angiography confirmed CAD in 241 patients (62 received CABG) and non-CAD in 121 (55 received valve replacement).
  
  
  RESULTS
  Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients (P < 0.05), but APN and CTRP9 were lower (P < 0.05). Serum levels of CTRP9 and APN were negatively related to BMI, HOMA-IR, TNF-α, IL-6, and leptin but positively to HDL-C (P < 0.05) in CAD patients. After adjustment of APN, CTRP9 was still related to the above parameters. Serum CTRP9 was a protective factor of CAD (P < 0.05). When compared with non-CAD patients, leptin mRNA expression increased dramatically, while CTRP9 mRNA expression reduced markedly in epicardial adipose tissue of CAD patients (P < 0.05). The leptin expression and macrophage count in CAD group were significantly higher than in non-CAD group, but CAD patients had a markedly lower CTRP9 expression (P < 0.05).
  
  
  CONCLUSIONS
  Circulating and coronary CTRP9 plays an important role in the inflammation and coronary atherosclerosis of CAD patients. Serum CTRP9 is an independent protective factor of CAD.
authors.affiliation: Department of Cardiology, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Hang
authors.affiliation: Department of Cardiology, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: Xun-Min
authors.initials: XM
authors.lastname: Cheng
authors.affiliation: Department of Cardiothoracic Surgery, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: De-Min
authors.initials: DM
authors.lastname: Li
authors.affiliation: Department of Cardiology, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: Qi-Gao
authors.initials: QG
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Peng
authors.affiliation: Department of Cardiology, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, China.
authors.forename: Jian-Bin
authors.initials: JB
authors.lastname: Gong
mesh_terms: D052242:Adiponectin / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D006023:Glycoproteins / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D006801:Humans; D020738:Leptin / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000096:biosynthesis; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
chemical_list: D052242:Adiponectin; C543615:C1QTNF9B protein, human; D006023:Glycoproteins; D020738:Leptin; D012333:RNA, Messenger; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins