title: [Distribution of HOMA-IR among children and adolescent in Zhangzhou and Zhongshan cities].
abstract: OBJECTIVE
  To investigate the distribution of the homeostasis model assessment of insulin resistance (HOMA-IR) among children and adolescent in Zhangzhou city and Zhongshan city.
  
  
  METHODS
  Total of 3102 children and adolescent aged 6 to 18-year-old were recruited, which were enrolled in a population-based cross-sectional study. Anthropometric and biochemical parameters were measured.
  
  
  RESULTS
  A total of 1528 (49.26%) girls and 1574 (50.74%) boys were included in this study. The concentrations of insulin and fasting glucose gradually increased from 6 to 18 years of age, there was no statistical difference between boys ang girls. The mean values for the BMI were similar in age-matched boys and girls from 6 to 18-year-old ,but for 12 to 15-year-old children was significantly higher in the girls compared with the boys and conversely for 16 to 18-year-old (P < 0.05). The HOMA-IR gradually increased with age and reached a plateau at 12 years of age and there was no markedly differential in gender.
  
  
  CONCLUSIONS
  The glucose levels, insulin concentrations and HOMA-IR exhibited a gradual increase with age. It was suggested that the evaluation of IR in children should be based on percentiles of the HOMA-IR rather than a dichotomous value derived from a single cutoff point.
authors.forename: Jinshui
authors.initials: J
authors.lastname: He
authors.forename: Guomo
authors.initials: G
authors.lastname: Lin
authors.forename: Yugui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Ye
authors.forename: Fuxing
authors.initials: F
authors.lastname: Liu
authors.forename: Linyong
authors.initials: L
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002681:China / Q000453:epidemiology; D002947:Cities; D003430:Cross-Sectional Studies; D005215:Fasting; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000208:ethnology / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin