title: Methylene Blue for Vasoplegia When on Cardiopulmonary Bypass During Double-Lung Transplantation.
abstract: Vasoplegia syndrome, characterized by hypotension refractory to fluid resuscitation or high-dose vasopressors, low systemic vascular resistance, and normal-to-increased cardiac index, is associated with increased morbidity and mortality after cardiothoracic surgery. Methylene blue inhibits inducible nitric oxide synthase and guanylyl cyclase, and has been used to treat vasoplegia during cardiopulmonary bypass. However, because methylene blue is associated with increased pulmonary vascular resistance, its use in patients undergoing lung transplantion has been limited. Herein, we report the use of methylene blue to treat refractory vasoplegia during cardiopulmonary bypass in a patient undergoing double-lung transplantation.
authors.affiliation: From the Department of Anesthesiology, NYP - Columbia University Medical Center, New York, New York.
authors.forename: Michelle
authors.initials: M
authors.lastname: Carley
authors.forename: Jacob
authors.initials: J
authors.lastname: Schaff
authors.forename: Terrance
authors.initials: T
authors.lastname: Lai
authors.forename: Jeremy
authors.initials: J
authors.lastname: Poppers
mesh_terms: D000328:Adult; D002315:Cardiopulmonary Bypass / Q000379:methods*; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D056987:Vasoplegia / Q000188:drug therapy* / Q000209:etiology
chemical_list: D004791:Enzyme Inhibitors; D008751:Methylene Blue