title: Dose-Response Functions for the Olfactory, Nasal Trigeminal, and Ocular Trigeminal Detectability of Airborne Chemicals by Humans.
abstract: We gathered from the literature 47 odor and 37 trigeminal (nasal and ocular) chemesthetic psychometric (i.e., detectability or dose-response) functions from a group of 41 chemicals. Vapors delivered were quantified by analytical methods. All functions were very well fitted by the sigmoid (logistic) equation: y = 1 / (1 + e({-(x-C)/D})), where parameter C quantifies the detection threshold concentration and parameter D the steepness of the function. Odor and chemesthetic functions showed no concentration overlap: olfactory functions grew along the parts per billion (ppb by volume) range or lower, whereas trigeminal functions grew along the part per million (ppm by volume) range. Although, on average, odor detectability rose from chance detection to perfect detection within 2 orders of magnitude in concentration, chemesthetic detectability did it within one. For 16 compounds having at least 1 odor and 1 chemesthetic function, the average gap between the 2 functions was 4.6 orders of magnitude in concentration. A quantitative structure-activity relationship (QSAR) using 5 chemical descriptors that had previously described stand-alone odor and chemesthetic threshold values, also holds promise to describe, and eventually predict, olfactory and chemesthetic detectability functions, albeit functions from additional compounds are needed to strengthen the QSAR.
authors.affiliation: University of California-San Diego, 8950 Villa La Jolla Drive, Suite C135, La Jolla, CA 92037, USA and ecometto@ucsd.edu.
authors.forename: J Enrique
authors.initials: JE
authors.lastname: Cometto-Muñiz
authors.affiliation: Department of Chemistry, University College London, London, UK.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Abraham
mesh_terms: D000393:Air Pollutants / Q000032:analysis* / Q000737:chemistry*; D003315:Cornea / Q000294:innervation*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009296:Nasal Cavity / Q000294:innervation*; D009812:Odorants / Q000032:analysis*; D009831:Olfactory Mucosa / Q000502:physiology*; D021281:Quantitative Structure-Activity Relationship; D012684:Sensory Thresholds; D012903:Smell / Q000502:physiology*; D014276:Trigeminal Nerve / Q000502:physiology*
chemical_list: D000393:Air Pollutants
keywords: chemesthetic detectability functions,; chemosensory detection; nasal and ocular irritation thresholds; odor detectability functions; odor thresholds; quantitative structure–activity relationships (QSAR); volatile organic compounds