title: Full factorial design optimization of anti-inflammatory drug release by PCL-PEG-PCL microspheres.
abstract: A biodegradable triblock poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) copolymer was successfully synthesized by ring-opening polymerization of ε-caprolactone, and was characterized by intrinsic viscosimetry, (1)H nuclear magnetic resonance, infrared spectroscopy and X-ray diffraction. Copolymer microparticles loaded with ibuprofen were prepared by an oil-in-water (o/w) emulsion solvent evaporation process. They were carefully weighted and characterized through their zeta potential. In this work, 4 selected process parameters (shaking speed X1, time of contact X2, poly(vinyl alcohol) concentration X3, and ibuprofen concentration X4) were adjusted at 2 different values. For each of the 16 experimental conditions, repeated twice, the drug encapsulation efficiency of the microspheres was determined, according to the following definition: EE (X1, X2, X3, X4)=mass of encapsulated ibuprofen/total weight of ibuprofen. A "full factorial design method" was applied to analyze the results statistically according to a polynomial fit and to determine the optimal conditions for the microencapsulation of the ibuprofen through an accurate statistical protocol. The microparticles obtained exhibit a spherical shape as shown by electron microscopy.
authors.affiliation: Laboratoire des Matériaux Organiques (LMO), Faculté des Sciences Exactes, Département de Chimie, Université de Bejaia, 06000 Bejaia Algérie. Electronic address: azouz.chimie@gmail.com.
authors.forename: L'Hachemi
authors.initials: L
authors.lastname: Azouz
authors.affiliation: Laboratoire de Biomathématiques, Biophysique, Biochimie et Scientométrie (L3BS-Bejaia), Faculté des Sciences de la Nature et de la Vie et des Sciences de la Terre, Université de Bouira 10000 Bouira, Algérie. Electronic address: farid.dahmoune@yahoo.fr.
authors.forename: Farid
authors.initials: F
authors.lastname: Dahmoune
authors.affiliation: Laboratoire des Matériaux Organiques (LMO), Faculté de Technologie, Département de Génie des Procédés, Université de Bejaia, 06000 Bejaia, Algérie. Electronic address: rezgui-farouk@netcourrier.com.
authors.forename: Farouk
authors.initials: F
authors.lastname: Rezgui
authors.affiliation: Université de Lorraine (France), Pôle scientifique M4, Institut Jean Lamour (UMR CNRS-UL 7198), Département SI2M, 54000 Nancy, France. Electronic address: gsell.christian@univ-lorraine.fr.
authors.forename: Christian
authors.initials: C
authors.lastname: G'Sell
mesh_terms: D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D065546:Drug Liberation; D007052:Ibuprofen / Q000737:chemistry / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D008970:Molecular Weight; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000893:Anti-Inflammatory Agents; D011091:Polyesters; C515340:poly(epsilon-caprolactone)-b-poly(ethyleneglycol)-b-poly(epsilon-caprolactone); D011092:Polyethylene Glycols; D007052:Ibuprofen
keywords: Biodegradable polymers; Ibuprofen; Microencapsulation; Microspheres; Poly(ethylene glycol); Poly(ε-caprolactone)