title: Content of HLA-G(+) T Cells in the Peripheral Blood from Healthy Women and Breast Cancer Patients.
abstract: The number of CD3(+)CD56-HLA-G(+) cells in the peripheral blood of breast cancer patients was shown to increase by 2 times. Our results and published data suggest that the increase in the relative content of CD3(+)CD56-HLA-G(+) cells in the circulating blood in breast cancer contributes to tumor development due to suppression of antitumor immunity.
authors.affiliation: Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan. katyostapchuk@gmail.ru.
authors.forename: E O
authors.initials: EO
authors.lastname: Ostapchuk
authors.affiliation: Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Perfi L'eva
authors.affiliation: AlmatyMammology Center, Kazakhstan Research Institute of Oncology and Radiology, Almaty, Kazakhstan.
authors.forename: Sh Zh
authors.initials: ShZh
authors.lastname: Talaeva
authors.affiliation: AlmatyMammology Center, Kazakhstan Research Institute of Oncology and Radiology, Almaty, Kazakhstan.
authors.forename: N A
authors.initials: NA
authors.lastname: Omarbaeva
authors.affiliation: Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan.
authors.forename: N N
authors.initials: NN
authors.lastname: Belyaev
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D017252:CD3 Complex / Q000235:genetics / Q000276:immunology; D019002:CD56 Antigen / Q000235:genetics / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry; D015870:Gene Expression; D059951:HLA-G Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D016130:Immunophenotyping; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology; D018655:Lymphocyte Count; D008875:Middle Aged; D009367:Neoplasm Staging; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000276:immunology
chemical_list: D017252:CD3 Complex; D019002:CD56 Antigen; D059951:HLA-G Antigens; C508609:IL10 protein, human; C522918:NCAM1 protein, human; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D007371:Interferon-gamma
keywords: HLA-G; TGFβ; interleukin-10; regulatory T cells