title: Transcranial magnetic stimulation and aging: Effects on spatial learning and memory after sleep deprivation in Octodon degus.
abstract: The benefits of neuromodulatory procedures as a possible therapeutic application for cognitive rehabilitation have increased with the progress made in non-invasive modes of brain stimulation in aged-related disorders. Transcranial magnetic stimulation (TMS) is a non-invasive method used to examine multiple facets of the human brain and to ameliorate the impairment in cognition caused by Alzheimer's disease (AD). The present study was designed to evaluate how a chronic TMS treatment could improve learning and memory functions after sleep deprivation (SD) in old Octodon degus. SD was executed by gently handling to keep the animals awake throughout the night. Thirty young and twenty-four old O. degus females were divided in six groups (control, acute and chronic TMS treatment). Behavioral tests included; Radial Arm Maze (RAM), Barnes Maze (BM) and Novel Object Recognition (NOR). Although learning and memory functions improved in young animals with only one session of TMS treatment, a significant improvement in cognitive performance was seen in old animals after 4 and 7days of TMS, depending on the task that was performed. No side effects were observed following, which showed therapeutic potential for improving age-related cognitive performance.
authors.affiliation: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia 30100, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Estrada
authors.affiliation: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia 30100, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Fernández-Gómez
authors.affiliation: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia 30100, Spain.
authors.forename: D
authors.initials: D
authors.lastname: López
authors.affiliation: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia 30100, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez-Cuello
authors.affiliation: Research Network on Ageing and Fragile (RETICEF), Department of Biochemistry and Molecular Biology, Faculty of Medicine, Maimonides Institute of Biomedical Research of Córdoba (IMIBIC), Córdoba University, Córdoba 14004, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Tunez
authors.affiliation: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia 30100, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Toledo
authors.affiliation: Department of Pharmacology, Aix-Marseille University, Marseille, France.
authors.forename: O
authors.initials: O
authors.lastname: Blin
authors.affiliation: Department of Medical Pharmacology, University Lille-North, 1 Place Verdun, 59045 Lille, France.
authors.forename: R
authors.initials: R
authors.lastname: Bordet
authors.affiliation: GlaxoSmithKline R&D, Neurosciences Therapeutic Area, Gunnels Wood Road, Stevenage, Herts SG1 2NY, United Kingdom.
authors.forename: J C
authors.initials: JC
authors.lastname: Richardson
authors.affiliation: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia 30100, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Fernandez-Villalba
authors.affiliation: Clinical & Experimental Neuroscience, Institute of Biomedical Research of Murcia (IMIB), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia 30100, Spain. Electronic address: mtherrer@um.es.
authors.forename: M T
authors.initials: MT
authors.lastname: Herrero
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D008568:Memory / Q000502:physiology*; D046329:Octodon; D012892:Sleep Deprivation / Q000503:physiopathology*; D065853:Spatial Learning / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation
keywords: Aging; Alzheimer disease; Octodon degus; Sleep deprivation; Transcranial magnetic stimulation (TMS)