title: Copper(II)-Mediated Aerobic Synthesis of Imidazo[1,2-a]pyridines via Cascade Aminomethylation/Cycloisomerization of Alkynes.
abstract: A single copper(II)-catalyzed three-component cascade aminomethylation/cycloisomerization of propiolates to form imidazo[1,2-a]pyridines was explored. A straightforward method was developed for the practical synthesis of functionalized imidazo[1,2-a]pyridines from benzaldehydes, 2-aminopyridines, and propiolate derivatives catalyzed by Cu(OAc)2 hydrate in the presence of air. The protocol is marked by excellent yields, functional group tolerance, and, above all, adaptability to synthesize imidazo[1,2-a]pyridine-based drug molecules such as Alpidem.
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , 47 Leninsky prosp., 119991 Moscow, Russia.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Rassokhina
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , 47 Leninsky prosp., 119991 Moscow, Russia.
authors.forename: Valerii Z
authors.initials: VZ
authors.lastname: Shirinian
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , 47 Leninsky prosp., 119991 Moscow, Russia.
authors.forename: Igor V
authors.initials: IV
authors.lastname: Zavarzin
authors.affiliation: Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Room 4500, Chicago, Illinois 60607, United States.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gevorgyan
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , 47 Leninsky prosp., 119991 Moscow, Russia.
authors.forename: Yulia A
authors.initials: YA
authors.lastname: Volkova