title: The unpaved journey of vitamin C in cancer treatment.
abstract: Effectiveness and low-toxicity to normal tissues are ideal properties for a cancer treatment, and one that numerous research programs are aiming for. Vitamin C has long been used in the field of Complementary and Alternative Medicine as a cancer treatment, with profound safety and anecdotal efficacy. Recent studies revealed the scientific basis for this use, and indicated that vitamin C, at supra-nutritional doses, holds considerable promise as an effective and low-toxic therapeutic strategy to treat cancer. Reviewed here are the early controversies surrounding vitamin C and cancer treatment, the breakthrough discoveries that led to the current advancement, and recent clinical studies, as well as research into its mechanisms of action.
authors.affiliation: Department of Pharmacology, Toxicology and Therapeutics. KU Integrative Medicine, the University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1018, Kansas City, KS 66160, USA.|Department of Pharmacology, Toxicology and Therapeutics. KU Integrative Medicine, the University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1018, Kansas City, KS 66160, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Pharmacology, Toxicology and Therapeutics. KU Integrative Medicine, the University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1018, Kansas City, KS 66160, USA.|Department of Pharmacology, Toxicology and Therapeutics. KU Integrative Medicine, the University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1018, Kansas City, KS 66160, USA.
authors.forename: Kishore
authors.initials: K
authors.lastname: Polireddy
authors.affiliation: Department of Pharmacology, Toxicology and Therapeutics. KU Integrative Medicine, the University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1018, Kansas City, KS 66160, USA.|Department of Pharmacology, Toxicology and Therapeutics. KU Integrative Medicine, the University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1018, Kansas City, KS 66160, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Pharmacology, Toxicology and Therapeutics. KU Integrative Medicine, the University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1018, Kansas City, KS 66160, USA.|Department of Pharmacology, Toxicology and Therapeutics. KU Integrative Medicine, the University of Kansas Medical Center, 3901 Rainbow Boulevard, MS1018, Kansas City, KS 66160, USA.
authors.forename: Ruochen
authors.initials: R
authors.lastname: Dong
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D001205:Ascorbic Acid
keywords: acide ascorbique; ascorbate; ascorbic acid; cancer; vitamin C; vitamine C