title: The Correlated Factors of Serum CA19-9 Levels in Diabetic Patients.
abstract: BACKGROUND
  Serum CA19-9 level is a sensitive marker for pancreatic tissue damage; however, its correlation factors are still unclear in diabetic patients. This study was aimed to investigate the correlation factors of serum CA 19-9 levels in these patients.
  
  
  RESULTS
  Based on their serum CA19-9 levels, 412 diabetic patients (57 type 1 and 355 type 2) were divided into the negative group (432 cases, CA19-9 37 U /ml) and the positive group (31 cases, CA19-9 ≥ 37 U /ml). The two groups were compared with age, sex, duration of diabetic history, hemoglobin A1c, blood lipid, fasting C-peptide level, and area under the curve C-peptide. The difference was significant between 2 groups in age, hemoglobin A1c, total cholesterol, highdensity lipoprotein cholesterol, fasting C-peptide level, and area under the curve C-peptide (P < 0.05). A multivariate linear regression model found that the type of diabetes, hemoglobin A1c, area under the curve C-peptide, and high-density lipoprotein cholesterol are the independent contributors to CA19-9 levels.
  
  
  CONCLUSIONS
  The results indicated that CA19-9 levels in patients with diabetes mellitus were related to not only age and sex but also diabetic type, hemoglobin A1c, lipid metabolism, and pancreatic beta cell function.
authors.affiliation: Division of Endocrinology, Aerospace Center Hospital, No 15, Yuquan Road, Haidian District, Beijing 100049, China.
authors.forename: Qiuming
authors.initials: Q
authors.lastname: Jiang
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.forename: Xiyang
authors.initials: X
authors.lastname: Zhang
authors.forename: Jennifer
authors.initials: J
authors.lastname: Pressley
authors.forename: Yuanjie
authors.initials: Y
authors.lastname: Mao
mesh_terms: D000293:Adolescent; D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D002096:C-Peptide / Q000097:blood; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D016014:Linear Models; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D055815:Young Adult
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D002096:C-Peptide; D002784:Cholesterol; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; C578959:carbohydrate antigen 199, human
keywords: C-peptide; CA19-9; Hemoglobin A1c; diabetes mellitus; high-density lipoprotein cholesterol; total cholesterol