title: Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells.
abstract: A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5-28.5 μM.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors.forename: Hari
authors.initials: H
authors.lastname: Jang
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors.forename: Qinghao
authors.initials: Q
authors.lastname: Jin
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors.forename: Jeong Yeon
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Korea.
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors.forename: Sang Bae
authors.initials: SB
authors.lastname: Han
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea.
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea. byhwang@chungbuk.ac.kr.
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
mesh_terms: D000818:Animals; D035264:Flowers; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D000067996:RAW 264.7 Cells; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D031207:Tussilago
chemical_list: D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide
keywords: Asteraceae; Nitric oxide production inhibitor; Oplopane-type sesquiterpenoid; Tussilago farfara