title: Diuretic Renal Scintigraphy in Patients with Sulfonamide Allergies: Possible Alternative Use of Ethacrynic Acid.
abstract: Furosemide may trigger life-threatening sulfonamide cross-hypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy.
  
  
  METHODS
  We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging results.
  
  
  RESULTS
  Diuretic renal scintigraphy using ethacrynic acid provided useful information about the obstruction status in all patients, with no adverse clinical impact.
  
  
  CONCLUSIONS
  Ethacrynic acid is a potential alternative to furosemide for patients with severe sulfonamide reactions.
authors.affiliation: Department of Radiology, Mayo Clinic, Scottsdale, Arizona; and nguyen.ba@mayo.edu.
authors.forename: Ba D
authors.initials: BD
authors.lastname: Nguyen
authors.affiliation: Department of Radiology, Mayo Clinic, Scottsdale, Arizona; and.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Roarke
authors.affiliation: Department of Radiology, Maricopa Integrated Health System, Phoenix, Arizona.
authors.forename: Jason Robert
authors.initials: JR
authors.lastname: Young
authors.affiliation: Department of Radiology, Mayo Clinic, Scottsdale, Arizona; and.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Radiology, Mayo Clinic, Scottsdale, Arizona; and.
authors.forename: Howard H
authors.initials: HH
authors.lastname: Osborn
mesh_terms: D000328:Adult; D004232:Diuretics / Q000494:pharmacology*; D004976:Ethacrynic Acid / Q000494:pharmacology*; D005260:Female; D005665:Furosemide / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D008297:Male; D011877:Radionuclide Imaging / Q000379:methods*
chemical_list: D004232:Diuretics; D005665:Furosemide; D004976:Ethacrynic Acid
keywords: diuretic renal scintigraphy; ethacrynic acid; sulfonamide allergy