title: The effect of omega-3 on serum lipid profile in hemodialysis patients.
abstract: BACKGROUND
  One of the major complications in hemodialysis patients is cardiovascular disease. Lipid abnormality is an important factor in the development of cardiovascular disease.
  
  
  OBJECTIVE
  To investigate the effect of omega-3 supplementation on serum lipid profile in hemodialysis patients.
  
  
  METHODS
  This randomized clinical trial study included 2 groups of patients: those who received omega-3 supplementation (experimental group; 30 cases) and those who received placebo (control group; 30 cases). They received these for 10 weeks and serum lipid profile (triglyceride, high-density lipoprotein [HDL-C], low-density lipoprotein [LDL-C], and total cholesterol) was assessed 2 times, first before initiating supplementation and then at the end of 10-week study period.
  
  
  RESULTS
  Mean (±SD) serum total cholesterol levels at the beginning was 163 (±47) mg/dL in experimental group and 143 (±25) mg/dL in control group (P> 0.05). These values decreased to 124 mg/dL and 132 mg/dL in control and experimental groups (P< 0.05). There was no significant difference of HDL-C, LDL-C, or triglyceride levels between experimental and control groups after 10 weeks of treatment.
  
  
  CONCLUSIONS
  Omega-3 supplementation in hemodialysis patients only showed significant decrease of serum total cholesterol level, but not other lipids.
authors.affiliation: Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Omrani
authors.affiliation: Department of Nutrition, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Pasdar
authors.affiliation: Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Daryosh
authors.initials: D
authors.lastname: Raisi
authors.affiliation: Research Center of Environmental Determinant of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Farid
authors.initials: F
authors.lastname: Najafi
authors.affiliation: Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Esfandiari
keywords: Hemodialysis; Omega 3; Serum lipids