title: CTRP1 protects against diet-induced hyperglycemia by enhancing glycolysis and fatty acid oxidation.
abstract: Complement-C1q/tumor necrosis factor-α related protein 1 (CTRP1) is a 35-kDa glycoprotein that is secreted from various tissues. Although CTRP1 is highly increased in patients with type II diabetes and obesity, the metabolic roles of CTRP1 remain largely unknown. To unveil the physiological roles of CTRP1 in vivo, CTRP1 transgenic (TG) mice were challenged by a high-fat diet (HFD) and a high-sucrose drink (HS). Homeostatic model assessment-estimated insulin resistance values were decreased in HFD- or HS-fed CTRP1 TG mice compared with wild-type control mice. In this context, CTRP1 stimulated glucose uptake through the glucose transporter GLUT4 translocation to the plasma membrane and also increased glucose consumption by stimulating glycolysis. To analyze the roles of CTRP1 in lipid metabolism, acetyl-CoA carboxylase (ACC) and hormone-sensitive lipase levels were determined in CTRP1 TG mice, and the effect of CTRP1 on fatty acid oxidation was assessed in C2C12 myotubes. CTRP1 was found to inhibit ACC by phosphorylation and to stimulate fatty acid oxidation in C2C12 myotubes. Taken together, CTRP1 performs active catabolic roles in vivo. Therefore, CTRP1 seems to perform a defensive function against nutritional challenges.
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea.
authors.forename: Sora
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea.
authors.forename: Jeong Su
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea.
authors.forename: Sunyi
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea.
authors.forename: Ae Lee
authors.initials: AL
authors.lastname: Jeong
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea.
authors.forename: Ki Sook
authors.initials: KS
authors.lastname: Oh
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea.
authors.forename: Hye In
authors.initials: HI
authors.lastname: Ka
authors.affiliation: Pathology Department, University of Ulsan College of Medicine Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Hyun-Ji
authors.initials: HJ
authors.lastname: Choi
authors.affiliation: Pathology Department, University of Ulsan College of Medicine Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Woo-Chan
authors.initials: WC
authors.lastname: Son
authors.affiliation: Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Won-Young
authors.initials: WY
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Suk Joong
authors.initials: SJ
authors.lastname: Oh
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea.
authors.forename: Jong-Seok
authors.initials: JS
authors.lastname: Lim
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea.
authors.forename: Myeong-Sok
authors.initials: MS
authors.lastname: Lee
authors.affiliation: Department of Life Systems, Sookmyung Women's University, Seoul, Republic of Korea. Electronic address: yyang@sm.ac.kr.
authors.forename: Young
authors.initials: Y
authors.lastname: Yang
mesh_terms: D041721:3T3-L1 Cells; D054392:Adipokines / Q000502:physiology*; D000818:Animals; D004032:Diet; D059305:Diet, High-Fat; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism*; D006019:Glycolysis; D006943:Hyperglycemia / Q000209:etiology / Q000517:prevention & control*; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D054392:Adipokines; C570300:CTRP1 protein, mouse; D005227:Fatty Acids
keywords: Fatty acid oxidation; Glycolysis; High-fat diet; High-sucrose diet; Hyperglycemia; Insulin resistance