title: Ring-Closing Metathesis with Vicinal Dibromoalkenes as Protected Alkynes: A Synthetic Approach to Macrocyclic Enynes.
abstract: A new strategy to access macrocyclic enynes was developed. To block undesired ene-yne cyclization pathways, alkynes were protected via bromination and the resultant acyclic vic-(E)-dibromotrienes participated in selective ene-ene ring closing metathesis reactions. Zinc-promoted deprotection of (E)-dibromodienes provided macrocyclic enynes in high yields.
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095-1569, United States.
authors.forename: Sedef
authors.initials: S
authors.lastname: Karabiyikoglu
authors.affiliation: Department of Chemistry and Biochemistry, California State University , San Marcos, California 92078, United States.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Iafe
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095-1569, United States.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Merlic