title: Evaluation of electrocardiographic parameters in patients with diabetes insipidus.
abstract: BACKGROUND
  There is limited data regarding the effect of altered serum osmolality on cardiac electrical activity. The aim of the present study is to evaluate the electrocardiographic (ECG) effects of diabetes insipidus (DI) and any related hyperosmolality in a population of young patients with DI and without any known cardiovascular disease or risk factors.
  
  
  METHODS
  Twelve-lead ECG's of 44 consecutive untreated young male patients (age: 21.8 ± 2.9 years) who had been referred to endocrinology clinic and diagnosed as DI based on water deprivation test were retrospectively evaluated. A total of 30 age-matched (21.9 ± 2.4 years) healthy males were selected as control group and ECG's of these controls were obtained for comparison with ECG's of DI patients. All ECG parameters were measured and compared.
  
  
  RESULTS
  Duration of QRS complex was significantly shorter in patients with DI compared with controls (85.2 ± 12.0 vs. 94.0 ± 10.6 ms, p: 0.001). P wave dispersion (PWD) of patients with DI was significantly higher compared with controls (31.9 ± 9.9 vs. 26.5 ± 10.6 ms, p: 0.03) and it was significantly correlated with serum osmolality and serum sodium level (r = - 0.36, p: 0.02 and r: - 0.35, p: 0.02, respectively).
  
  
  CONCLUSIONS
  DI patients without any cardiovascular disease or risk factors displayed significantly shorter QRS duration and increased p wave dispersion compared with controls.
authors.affiliation: Department of Endocrinology and Metabolism, Haydarpasa Training Hospital, Gulhane Military Medical Academy, Istanbul, Turkey.
authors.forename: Ferhat
authors.initials: F
authors.lastname: Deniz
authors.affiliation: Department of Cardiology, Marmara University Training and Research Hospital, Pendik, Istanbul, Turkey. alperkepez@yahoo.com.
authors.forename: Alper
authors.initials: A
authors.lastname: Kepez
authors.affiliation: Department of Endocrinology and Metabolism, Haydarpasa Training Hospital, Gulhane Military Medical Academy, Istanbul, Turkey.
authors.forename: Seyit Ahmet
authors.initials: SA
authors.lastname: Ay
authors.affiliation: Department of Cardiology, Marmara University Training and Research Hospital, Pendik, Istanbul, Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Ergogan
authors.affiliation: Department of Endocrinology and Metabolism, Haydarpasa Training Hospital, Gulhane Military Medical Academy, Istanbul, Turkey.
authors.forename: Kamil
authors.initials: K
authors.lastname: Baskoy
authors.affiliation: Department of Public Health, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Mustafa Nuri
authors.initials: MN
authors.lastname: Guncıkan
authors.affiliation: Department of Cardiology, Marmara University Training and Research Hospital, Pendik, Istanbul, Turkey.
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Dogan
authors.affiliation: Department of Endocrinology and Metabolism, Haydarpasa Training Hospital, Gulhane Military Medical Academy, Istanbul, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Yonem
mesh_terms: D000328:Adult; D003919:Diabetes Insipidus / Q000175:diagnosis* / Q000503:physiopathology*; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
keywords: Diabetes insipidus; Electrocardiography; Electrolytes; Osmolality; QRS duration; Sodium