title: Fabrication of electrochemical sensor for paracetamol based on multi-walled carbon nanotubes and chitosan-copper complex by self-assembly technique.
abstract: An electrochemical sensor for paracetamol based on multi-walled carbon nanotubes and chitosan-copper complex (MWCNTs/CTS-Cu) was fabricated by self-assembly technique. The MWCNTs/CTS-Cu modified GCE showed an excellent electrocatalytic activity for the oxidation of paracetamol, and accelerated electron transfer between the electrode and paracetamol. Under optimal experimental conditions, the differential pulse peak current was linear with the concentration of paracetamol in the range of 0.1-200 μmol L(-1) with a detection limit of 0.024 μmol L(-1). The sensitivity was found to be 0.603 A/mol L(-1). The proposed sensor also showed a high selectivity for paracetamol in the presence of ascorbic acid and dopamine. Moreover, the proposed electrode revealed good reproducibility and stability. The proposed method was successfully applied for the determination of paracetamol in tablet and human serum samples.
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China; School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China.
authors.forename: Airong
authors.initials: A
authors.lastname: Mao
authors.affiliation: School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China; Department of Chemical Engineering, Yangzhou Polytechnic Institute, Yangzhou 225127, China.
authors.forename: Dangqin
authors.initials: D
authors.lastname: Jin
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China; School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China.
authors.forename: Liangyun
authors.initials: L
authors.lastname: Yu
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China. Electronic address: xyhu@yzu.edu.cn.
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Hu
mesh_terms: D000082:Acetaminophen / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004298:Dopamine / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D015203:Reproducibility of Results; D013607:Tablets / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D013607:Tablets; D000082:Acetaminophen; D003300:Copper; D048271:Chitosan; D001205:Ascorbic Acid; D004298:Dopamine
keywords: Chitosan; Copper; Multi-walled carbon nanotubes; Paracetamol; Self-assembly