title: Predicting the Functional Types of Singleplex and Multiplex Eukaryotic Membrane Proteins via Different Models of Chou's Pseudo Amino Acid Compositions.
abstract: Given a membrane protein sequence, how can we identify its type, particularly when a query protein may have the multiplex character, i.e., simultaneously exist at two or more different types. However, most of the existing predictors or methods can only be used to deal with the single-type or "singleplex" membrane proteins. Actually, multiple-type or "multiplex" membrane proteins should not be ignored because they usually posses some unique biological functions worthy of our special notice. In this study, three different models were developed, which have the ability to deal with the systems containing both singleplex and multiplex membrane proteins. The overall success rate thus obtained was 0.6440, indicating that the study may become a very useful high-throughput tool in identifying the functional types of membrane proteins.
authors.affiliation: Computer Department, Jing-De-Zhen Ceramic Institute, Jing-De-Zhen, 333046, China. hongliangzou@126.com.
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Zou
authors.affiliation: Computer Department, Jing-De-Zhen Ceramic Institute, Jing-De-Zhen, 333046, China. jdzxiaoxuan@163.com.|Information School, ZheJiang Textile & Fashion College, Ningbo, 315211, China. jdzxiaoxuan@163.com.|Gordon Life Science Institute, 53 South Cottage Road, Belmont, MA, 02478, USA. jdzxiaoxuan@163.com.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xiao
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D030562:Databases, Protein; D056890:Eukaryota / Q000378:metabolism*; D019143:Evolution, Molecular; D057927:Hydrophobic and Hydrophilic Interactions; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008962:Models, Theoretical; D015203:Reproducibility of Results
chemical_list: D000596:Amino Acids; D008565:Membrane Proteins
keywords: Functional types; Multiplex membrane proteins; Singleplex membrane proteins; Success rate