title: Quantitative assessment of common genetic variations in HLA-DP with hepatitis B virus infection, clearance and hepatocellular carcinoma development.
abstract: Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, genome-wide association studies have identified human leukocyte antigen (HLA)-DP polymorphisms (rs3077 and rs9277535) as a new chronic HBV infection susceptibility locus. Since then, the relationship between HLA-DP polymorphisms and various outcomes of HBV infection has been reported. However, the results have been inconclusive. To derive a more precise estimation of the relationship between HLA-DP polymorphisms and various outcomes of HBV infection, a meta-analysis of 62,050 subjects from 29 case-control studies was performed. We found that rs3077 and rs9277535 in HLA-DP significantly decreased HBV infection risks and increased HBV clearance possibility in a dose-dependent manner. In the subgroup analysis by ethnicity, study design and sample size, significant associations were found for these polymorphisms in almost all comparisons. Meanwhile, haplotype analyses of the two polymorphisms revealed a significant association between the combination of these alleles and HBV infection outcomes. However, no significant results were observed in HCC development. Our results further confirm that genetic variants in the HLA-DP locus are strongly associated with reduced HBV infection and increased the likelihood of spontaneous viral clearance.
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.affiliation: The First Affiliated Hospital, Soochow University, Shizi Street 188, Suzhou 215006, Jiangsu, China.
authors.forename: Yi-ju
authors.initials: YJ
authors.lastname: Cheng
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Ming-liang
authors.initials: ML
authors.lastname: Cheng
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Yao
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Xue-ke
authors.initials: XK
authors.lastname: Zhao
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Hua-juan
authors.initials: HJ
authors.lastname: Liu
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Ya-xin
authors.initials: YX
authors.lastname: Hu
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Mu
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.|Department of Eugenics and Genetics, Guiyang Maternal and Child Health-Care Hospital, Ruijin South Road 63, Guiyang 550003, Guizhou, China.
authors.forename: Bi
authors.initials: B
authors.lastname: Wang
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Guo-zhen
authors.initials: GZ
authors.lastname: Yang
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Li-li
authors.initials: LL
authors.lastname: Zhu
authors.affiliation: The Affiliated Hospital, Guizhou Medical University, Beijing Road 9, Guiyang 550004, Guizhou, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D015984:Causality; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D055106:Genome-Wide Association Study; D006682:HLA-DP Antigens / Q000235:genetics*; D006509:Hepatitis B / Q000453:epidemiology* / Q000235:genetics* / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000821:virology; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011230:Precancerous Conditions; D015995:Prevalence; D018570:Risk Assessment; D017735:Virus Latency / Q000235:genetics
chemical_list: D006682:HLA-DP Antigens