title: Autophagy : Moving Benchside Promises to Patient Bedsides.
abstract: Survival rates of patients with metastatic or recurrent cancers have remained virtually unchanged during the past 30 years. This fact makes the need for new therapeutic options even more urgent. An attractive option would be to target autophagy, an essential quality control process that degrades toxic aggregates, damaged organelles, and signaling proteins, and acts as a tumor suppressor pathway of tumor initiation. Conversely, other fascinating observations suggest that autophagy supports cancer progression, relapse, metastasis, dormancy and resistance to therapy. This review provides an overview of the contradictory roles that autophagy plays in cancer initiation and progression and discusses the promises and challenges of current strategies that target autophagy for cancer therapy.
authors.forename: Amine
authors.initials: A
authors.lastname: Belaid
authors.forename: Papa Diogop
authors.initials: PD
authors.lastname: Ndiaye
authors.forename: Harilaos
authors.initials: H
authors.lastname: Filippakis
authors.forename: Jérémie
authors.initials: J
authors.lastname: Roux
authors.forename: Éric
authors.initials: É
authors.lastname: Röttinger
authors.forename: Yacine
authors.initials: Y
authors.lastname: Graba
authors.forename: Patrick
authors.initials: P
authors.lastname: Brest
authors.forename: Paul
authors.initials: P
authors.lastname: Hofman
authors.affiliation: Institute of Research on Cancer and Ageing of Nice (IRCAN); Université de Nice-Sophia Antipolis; Centre Antoine Lacassagne, Avenue de Valombrose; 06107 Nice Cedex 02, France. mograbi@unice.fr.
authors.forename: Baharia
authors.initials: B
authors.lastname: Mograbi
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001343:Autophagy; D016503:Drug Delivery Systems; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy*; D000067716:Point-of-Care Testing
chemical_list: D000970:Antineoplastic Agents