title: Report on the second WHO integrated meeting on development and clinical trials of influenza vaccines that induce broadly protective and long-lasting immune responses: Geneva, Switzerland, 5-7 May 2014.
abstract: On 5-7 May 2014, the World Health Organization (WHO) convened the second integrated meeting on "influenza vaccines that induce broadly protective and long-lasting immune responses". Around 100 invited experts from academia, the vaccine industry, research and development funders, and regulatory and public health agencies attended the meeting. Areas covered included mechanisms of protection in natural influenza-virus infection and vaccine-induced immunity, new approaches to influenza-vaccine design and production, and novel routes of vaccine administration. A timely focus was on how this knowledge could be applied to both seasonal influenza and emerging viruses with pandemic potential such as influenza A (H7N9), currently circulating in China. Special attention was given to the development of possible universal influenza vaccines, given that the Global Vaccine Action Plan calls for at least one licensed universal influenza vaccine by 2020. This report highlights some of the topics discussed and provides an update on studies published since the report of the previous meeting.
authors.affiliation: Influenza Division, National Center for Infectious Diseases, 1600 Clifton Road NE, Atlanta, GA 30333, United States.
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Cox
authors.affiliation: Working in Tandem Ltd, Cambridge CB1 7AB, United Kingdom.
authors.forename: Julian
authors.initials: J
authors.lastname: Hickling
authors.affiliation: Working in Tandem Ltd, Cambridge CB1 7AB, United Kingdom.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Jones
authors.affiliation: Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, Rotterdam CE 3015, The Netherlands.
authors.forename: Guus F
authors.initials: GF
authors.lastname: Rimmelzwaan
authors.affiliation: Respiratory Diseases Branch, Division of Microbiology and Infectious Diseases, NIAID/NIH/DHHS, 5601 Fishers Lane, Bethesda, MD 20892, United States.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Lambert
authors.affiliation: PATH, 445 Massachusetts Avenue, NW Suite 1000, Washington, DC 20001, United States.
authors.forename: John
authors.initials: J
authors.lastname: Boslego
authors.affiliation: Institute of Experimental Medicine, Russian Academy of Medical Sciences, 12 Acad. Pavlov Street, St Petersburg 197376, Russian Federation.
authors.forename: Larisa
authors.initials: L
authors.lastname: Rudenko
authors.affiliation: Vaccine Production, Serum Institute of India, 212/2 Hadapsar, Pune, India.
authors.forename: Leena
authors.initials: L
authors.lastname: Yeolekar
authors.affiliation: Independent Consultant, St. Albans, United Kingdom.
authors.forename: James S
authors.initials: JS
authors.lastname: Robertson
authors.affiliation: Initiative for Vaccine Research (IVR), Immunization, Vaccines and Biologicals (IVB), World Health Organization, Switzerland.
authors.forename: Joachim
authors.initials: J
authors.lastname: Hombach
authors.affiliation: Initiative for Vaccine Research (IVR), Immunization, Vaccines and Biologicals (IVB), World Health Organization, Switzerland.
authors.forename: Justin R
authors.initials: JR
authors.lastname: Ortiz
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D002986:Clinical Trials as Topic; D056738:Cross Protection; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D058873:Pandemics / Q000517:prevention & control; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology; D014944:World Health Organization
chemical_list: D000276:Adjuvants, Immunologic; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated
keywords: H7N9 vaccine; Influenza; Pandemic influenza vaccine; Seasonal influenza vaccine; Universal influenza vaccine; Vaccine