title: Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder that primarily compromises memory formation and storage. Several hypotheses regarding the pathogenesis of AD have been proposed; however, no cure is available to date. Here we describe the calcium hypothesis of AD, which is gaining popularity. We present data supporting this hypothesis and focus on a recently discovered calcium-signaling pathway that is dysregulated in AD and propose targets for the development of disease-modifying therapies.
authors.affiliation: Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St Petersburg Polytechnic University, St Petersburg, Russian Federation.
authors.forename: Elena
authors.initials: E
authors.lastname: Popugaeva
authors.affiliation: Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St Petersburg Polytechnic University, St Petersburg, Russian Federation.
authors.forename: Olga L
authors.initials: OL
authors.lastname: Vlasova
authors.affiliation: Laboratory of Molecular Neurodegeneration, Department of Medical Physics, Peter the Great St Petersburg Polytechnic University, St Petersburg, Russian Federation.|Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Ilya
authors.initials: I
authors.lastname: Bezprozvanny
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism*; D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects* / Q000502:physiology*; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology*; D006801:Humans
keywords: Alzheimer disease; Ca2+ signaling; mushroom spine; neuronal store-operated Ca2+ channels; synapse