title: Facile synthesis of glucose-sensitive chitosan-poly(vinyl alcohol) hydrogel: Drug release optimization and swelling properties.
abstract: The study describes the development of glucose-sensitive hydrogel and optimization of bovine serum albumin release profile from the hydrogel. To enhance the glucose sensitivity and improve the swelling behaviors of the hydrogel system, boric acid crosslinking, and freeze-thawing cycle techniques were used to prepare chitosan-poly(vinyl alcohol) hydrogel. The structure of the resultant hydrogel was confirmed by scanning electron microscopy and Fourier transform infrared spectroscopy. The experimental results revealed that the swelling of the hydrogel was influenced by the pH of the medium, and the hydrogel displayed explicit glucose-sensitivity under physiological conditions. The values of the diffusion exponent range between 0.34 and 0.44 and the diffusion of water into the gel system are assumed to be pseudo-Fickian in nature. Under optimized conditions, the cumulative Bovine serum albumin (BSA) drug releases ranged between 69.33±1.95% and 86.45±1.16% at 37°C in the presence of glucose and pH 7.4, respectively.
authors.affiliation: Department of Chemistry, Eastern Mediterranean University, Gazimagusa, TRNC via Mersin 10, Turkey; Faculty of Pharmacy, Eastern Mediterranean University, Gazimagusa, TRNC via Mersin 10, Turkey. Electronic address: mosab.abureesh@emu.edu.tr.
authors.forename: Mosab Ali
authors.initials: MA
authors.lastname: Abureesh
authors.affiliation: Department of Chemistry, Eastern Mediterranean University, Gazimagusa, TRNC via Mersin 10, Turkey. Electronic address: akeem.oladipo@emu.edu.tr.
authors.forename: Akeem Adeyemi
authors.initials: AA
authors.lastname: Oladipo
authors.affiliation: Department of Chemistry, Eastern Mediterranean University, Gazimagusa, TRNC via Mersin 10, Turkey. Electronic address: mustafa.gazi@emu.edu.tr.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gazi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002417:Cattle; D048271:Chitosan / Q000737:chemistry*; D065546:Drug Liberation; D005947:Glucose / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012710:Serum Albumin, Bovine; D011142:Polyvinyl Alcohol; D048271:Chitosan; D005947:Glucose
keywords: Chitosan; Drug release; Glucose response hydrogels; Optimization; PVA