title: Two cases of adult-onset Still's disease with orbital inflammatory lesions originating from the lacrimal gland.
abstract: Orbital inflammation has been rarely associated with adult-onset Still's disease (AOSD). We herein describe two AOSD patients who developed lacrimal gland enlargement with inflammation spreading to the contiguous tissues in the orbit. Case 1 was a 26-year-old woman who developed bilateral eyelid swelling while taking prednisolone (22.5 mg/day) for AOSD. The swelling of the eyelid worsened after other symptoms emerged, such as a fever, a rash, and arthritis. The laboratory findings, including leukocytosis, liver dysfunction, and ferritin elevation, also suggested an AOSD flare-up. Case 2 was a 62-year-old woman who presented with left eyelid swelling. She was diagnosed with AOSD at 45 years of age but sustained remission. During admission, she subsequently developed a fever, a rash, arthritis, lymphadenopathy, and ocular hyperemia. AOSD was suspected from the clinical course. We speculate that dacryoadenitis and orbital inflammation are manifestations of AOSD.
authors.affiliation: Division of Rheumatic Diseases, National Center for Global Health and Medicine, Japan.
authors.forename: Ei
authors.initials: E
authors.lastname: Bannai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamashita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Haruka
authors.initials: H
authors.lastname: Tsuchiya
authors.forename: Akio
authors.initials: A
authors.lastname: Mimori
mesh_terms: D000328:Adult; D005076:Exanthema / Q000209:etiology; D005128:Eye Diseases / Q000209:etiology*; D005260:Female; D005293:Ferritins / Q000097:blood; D005334:Fever / Q000209:etiology; D006801:Humans; D007765:Lacrimal Apparatus; D007964:Leukocytosis / Q000097:blood; D008111:Liver Function Tests; D008875:Middle Aged; D016706:Still's Disease, Adult-Onset / Q000150:complications* / Q000503:physiopathology*
chemical_list: D005293:Ferritins