title: Advanced Cancer Patients' Understanding and Perceptions of Phase I Clinical Trials.
abstract: This questionnaire-based study assessed the understanding and perceptions of cancer patients who were participating in a Phase I clinical trial at baseline and determined any changes after enrollment. Thirty-six patients participated. Less than one-third of respondents (28.5%) thought the purpose of Phase I trials was dose escalation for safety and efficacy. Patients anticipated varying degree of therapeutic benefit ranging from stable disease (47.1%) to complete shrinkage of the tumor (32.4%). No change in measured themes was observed. Patients participating in Phase I trials need further education to improve their understanding of the true intent of early Phase trials.
authors.affiliation: a Department of Medicine, Division of Hematology/Oncology , University of Texas Health Science Center , San Antonio , TX , USA.
authors.forename: Jamie
authors.initials: J
authors.lastname: Pawlowski
authors.affiliation: a Department of Medicine, Division of Hematology/Oncology , University of Texas Health Science Center , San Antonio , TX , USA.|b Institute for Drug Development , University of Texas Health Science Center , San Antonio , TX , USA.|c Cancer Therapy and Research Center , University of Texas Health Science Center , San Antonio , TX , USA.
authors.forename: Laeeq
authors.initials: L
authors.lastname: Malik
authors.affiliation: a Department of Medicine, Division of Hematology/Oncology , University of Texas Health Science Center , San Antonio , TX , USA.|b Institute for Drug Development , University of Texas Health Science Center , San Antonio , TX , USA.|c Cancer Therapy and Research Center , University of Texas Health Science Center , San Antonio , TX , USA.
authors.forename: Devalingam
authors.initials: D
authors.lastname: Mahalingam
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic / Q000941:ethics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D011795:Surveys and Questionnaires
keywords: Chemotherapy; Clinical trials; Medical ethics