title: Combination of genetic variants in cyclin D1 and retinoblastoma genes predict clinical outcome in oral cancer patients.
abstract: Oral cancer is a dreadful disease with a wide variation in geographical distribution. In order to identify some useful biomarkers for the disease prognosis, the present study assessed the influence of single nucleotide polymorphisms (SNPs) in cell cycle genes on survival in a well-annotated set of patients with oral squamous cell carcinoma (OSCC). The study examined 12 sequence variants or SNPs in selected cell cycle genes, with prognostic outcomes in 311 oral cancer patients. Our analysis showed that SNPs in cyclin D1:rs9344 and retinoblastoma:rs427686 genes showed a strong correlation with disease-free survival. In addition, the cumulative effect of these SNPs significantly and independently predicts the survival. Thus, the current study identified genotypes (SNP signature), which can be used as novel prognostic biomarkers to stratify patients based on disease-free survival and therefore maybe helpful in therapeutic decision-making.
authors.affiliation: Laboratory of Cell Cycle Regulation & Molecular Oncology, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, 695 011, Kerala, India.
authors.forename: Abitha
authors.initials: A
authors.lastname: Murali
authors.affiliation: Division of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, 695 011, Kerala, India.
authors.forename: Bipin T
authors.initials: BT
authors.lastname: Varghese
authors.affiliation: Division of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, 695 011, Kerala, India.
authors.forename: R Rejnish
authors.initials: RR
authors.lastname: Kumar
authors.affiliation: Laboratory of Cell Cycle Regulation & Molecular Oncology, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, 695 011, Kerala, India. kannans@rcctvm.gov.in.
authors.forename: S
authors.initials: S
authors.lastname: Kannan
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D016161:Genes, Retinoblastoma / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D019938:Cyclin D1
keywords: Cell cycle; Oral cancer; Prognosis; Single nucleotide polymorphism