title: Burkitt leukemia limited to the bone marrow has a better prognosis than Burkitt lymphoma with bone marrow involvement in adults.
abstract: Burkitt lymphoma patients with bulky disease often have bone marrow involvement. However, leukemic presentation of Burkitt lymphoma in the absence of a mass (pure Burkitt leukemia; PBL) is uncommon. Both PBL and Burkitt lymphoma/leukemia, presenting with a tumor mass and marrow involvement (BLL), are considered stage IV disease, which is associated with a poor prognosis. However, there is limited information on the prognosis in adults with PBL because they have typically been included in cohorts of patients with BLL. This study identified 23 patients, which included 10 PBL and 13 BLL cases. Complex karyotypes (100%) were seen in all BLL cases compared to the PBL group (40%; p = 0.061). Patients with PBL had a significantly better 5-year overall survival of 87.5% vs only 24.3% in the BLL group (p = 0.005). The 5-year overall survival of patients with PBL treated with intensive chemotherapy is superior to those with BLL who are similarly treated.
authors.affiliation: a Department of Pathology , City of Hope National Medical Center , Duarte , CA , USA .
authors.forename: Joo Y
authors.initials: JY
authors.lastname: Song
authors.affiliation: b Department of Pathology , University of Chicago , Chicago , IL , USA .
authors.forename: Girish
authors.initials: G
authors.lastname: Venkataraman
authors.affiliation: c Department of Pathology and Laboratory Medicine , University of North Carolina , Chapel Hill , NC , USA .
authors.forename: Yuri
authors.initials: Y
authors.lastname: Fedoriw
authors.affiliation: d Department of Hematology and Hematopoietic Cell Transplantation , Duarte , CA , USA .
authors.forename: Alex F
authors.initials: AF
authors.lastname: Herrera
authors.affiliation: d Department of Hematology and Hematopoietic Cell Transplantation , Duarte , CA , USA .
authors.forename: Tanya
authors.initials: T
authors.lastname: Siddiqi
authors.affiliation: b Department of Pathology , University of Chicago , Chicago , IL , USA .
authors.forename: Mir B
authors.initials: MB
authors.lastname: Alikhan
authors.affiliation: a Department of Pathology , City of Hope National Medical Center , Duarte , CA , USA .
authors.forename: Young S
authors.initials: YS
authors.lastname: Kim
authors.affiliation: a Department of Pathology , City of Hope National Medical Center , Duarte , CA , USA .
authors.forename: Joyce
authors.initials: J
authors.lastname: Murata-Collins
authors.affiliation: a Department of Pathology , City of Hope National Medical Center , Duarte , CA , USA .
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Weisenburger
authors.affiliation: e Department of Biostatistics , City of Hope National Medical Center , Duarte , CA , USA , and.
authors.forename: Xueli
authors.initials: X
authors.lastname: Liu
authors.affiliation: f Department of Pathology , Johns Hopkins University , Baltimore , MD , USA.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Duffield
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D002051:Burkitt Lymphoma / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D059785:Karyotype; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: Pure Burkitt leukemia; lymphoma