title: Diffuse Fluid-Attenuated Inversion Recovery Hyperintensity in Subarachnoid Space Following Cerebral Angiography and Intravenous Thrombolysis.
abstract: OBJECTIVE
  Transient cortical blindness (TCB) is a relatively rare but well-recognized complication following cardiovascular and cerebral angiography.
  
  
  METHODS
  A 68-year-old male developed TCB following cerebral angiography along with punctate diffusion lesion evident on emergent magnetic resonance imaging (MRI). The patient received intravenous tissue plasminogen activator (IV-tPA) for suspected stroke.
  
  
  RESULTS
  Follow-up MRI revealed diffuse hyperintensities in subarachnoid space in fluid-attenuated inversion recovery (FLAIR) sequence mostly in bilateral occipital lobes.
  
  
  CONCLUSIONS
  The finding on the FLAIR as described in this case is an indication of diffuse disruption of the blood-brain barrier perhaps secondary to cerebral angiography, high blood pressure, and IV-tPA. To the best of our knowledge, this is the first reported case of TCB with diffuse postcontrast FLAIR changes.
authors.affiliation: Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland. Electronic address: ramin.zand@gmail.com.
authors.forename: Ramin
authors.initials: R
authors.lastname: Zand
authors.affiliation: Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee.
authors.forename: Shailesh
authors.initials: S
authors.lastname: Male
authors.affiliation: Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
authors.forename: John K
authors.initials: JK
authors.lastname: Lynch
mesh_terms: D000368:Aged; D001766:Blindness / Q000209:etiology* / Q000473:pathology; D001812:Blood-Brain Barrier / Q000473:pathology*; D002533:Cerebral Angiography / Q000009:adverse effects*; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013346:Subarachnoid Space / Q000473:pathology*; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; C067262:PLAT protein, human; D010959:Tissue Plasminogen Activator
keywords: Cortical; angiography; blindness; magnetic resonance imaging