title: Demonstration of high coincidence of pituitary adenoma in patients with ruptured Rathke's cleft cyst: Results of a prospective study.
abstract: OBJECTIVE
  Repeated chronic inflammation, such as under circumstances of ruptured Rathke's cleft cyst (RCC), is known as the fundamental basis of various pathological changes including neoplastic change, therefore to examine accurate incidence of pituitary adenomas is important for the preventive medicine.
  
  
  METHODS
  As a prospective study, patients were initially screened by the symptoms such as periodic headache and dizziness together with the abnormal findings such as seller floor bone defect on 3D-CT. Those screened patients who showed abnormal basal pituitary hormone values were additionally examined by several loading test and 3T magnetic resonance imaging (MRI) by three-dimensional reconstructions of Flair cube images. The presence of pituitary adenomas was evaluated by composite 3T MRI and (11)C methionine MET positron-emission tomography imaging. Immunohistochemical studies were employed for surgical biopsy specimens to demonstrate hormone production.
  
  
  RESULTS
  308 cases of RCC were diagnosed by both radiologic and intraoperative findings. Pathological examination confirmed 111 pituitary adenomas in 106 patients with ruptured RCC, therefore the rate of coincidence was revealed 34%. In 78 patients with abnormalities of pituitary hormone secretion, MET uptake was observed in the pituitary gland and verified pituitary adenoma pathologically. In addition, 28 adenomas were verified without MET-PET study on pathological examination only, for a total of 106 cases.
  
  
  CONCLUSIONS
  High coincidence (34%) of ruptured RCC and pituitary adenomas was demonstrated, which is a proof that ruptured RCC is contributed to a risk factor of pituitary adenoma.
authors.affiliation: Research Institute for Pituitary Disease, Southern Tohoku General Hospital, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, Japan. Electronic address: ikeda@nsg.med.tohoku.ac.jp.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ikeda
authors.affiliation: Research Institute for Pituitary Disease, Southern Tohoku General Hospital, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, Japan.
authors.forename: Genichiro
authors.initials: G
authors.lastname: Ohhashi
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020863:Central Nervous System Cysts / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012307:Risk Factors; D055815:Young Adult
keywords: Chronic inflammation; MET-PET; Pituitary adenoma; Prospective study; Rathke's cleft cyst