title: Tris-(2,3-Dibromopropyl) Isocyanurate, a New Emerging Pollutant, Impairs Cognition and Provokes Depression-Like Behaviors in Adult Rats.
abstract: Tris-(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO), an emerging brominated flame retardant, possesses the characteristics of candidate persistent organic pollutants and has displayed toxicity to fish and rodents. TDBP-TAZTO can pass through the blood brain barrier and accumulate in brain. However, the neurotoxicity of TDBP-TAZTO has not yet studied in rodents. We hypothesize that TDBP-TAZTO could induce the neurotoxicity in rat hippocampal neurons. The male adult rats were exposed to TDBP-TAZTO of 5 and 50 mg/kg by gavage, daily for 6 months. TDBP-TAZTO resulted in cognitive impairment and depression-like behaviors, which may be related with TDBP-TAZTO-induced hypothalamic-pituitary-adrenal axis hyperactivation, upregulation of inflammatory and oxidative stress markers, overexpression of pro-apoptotic proteins, downexpression of neurogenesis-related proteins in hippocampus, and hippocampal neurons damage in DG, CA1 and CA3 areas. Our findings suggested that TDBP-TAZTO induces significant hippocampal neurotoxicity, which provokes cognitive impairment and depression-like behaviors in adult rats. Therefore, this research will contribute to evaluate the neurotoxic effects of TDBP-TAZTO in human.
authors.affiliation: School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, PR China; Institute of Toxicology, Binzhou Medical University, Yantai, Shandong, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ye
authors.affiliation: Medicine & Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, PR China.
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Hu
authors.affiliation: School of Pharmacy, Yantai University, Yantai, Shandong, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, PR China; Institute of Toxicology, Binzhou Medical University, Yantai, Shandong, PR China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhu
authors.affiliation: School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, PR China.
authors.forename: Zhaoju
authors.initials: Z
authors.lastname: Dong
authors.affiliation: School of Pharmacy, Binzhou Medical University, Yantai, Shandong, PR China.
authors.forename: Wanglin
authors.initials: W
authors.lastname: Jiang
authors.affiliation: School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, PR China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhao
authors.affiliation: School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Mi
authors.affiliation: School of Pharmacy, Yantai University, Yantai, Shandong, PR China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, PR China.
authors.forename: Xihou
authors.initials: X
authors.lastname: Hu
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D015415:Biomarkers / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003071:Cognition / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood; D016207:Cytokines / Q000378:metabolism; D003863:Depression / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D004785:Environmental Pollutants / Q000633:toxicity*; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D055495:Neurogenesis / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D009498:Neurotoxins / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D016708:Synaptophysin / Q000378:metabolism; D014227:Triazines / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D004785:Environmental Pollutants; D009498:Neurotoxins; D016708:Synaptophysin; D014227:Triazines; C541743:tris(2,3-dibromopropyl)isocyanurate; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone