title: Effect of lidocaine spray in pain management during office-based endometrial sampling: A randomised placebo-controlled trial.
abstract: Office-based endometrial sampling is the most frequently performed gynaecological procedure. The procedure is usually associated with pain and discomfort. Several anaesthetic and analgesic techniques (e.g., non-steroidal anti-inflammatory drugs, paracervical block, misoprostol and topical anaesthetics) are used for pain management during endometrial sampling. There is no comprehensive study using lidocaine in spray form; we sought to investigate the analgesic efficacy of 10% lidocaine spray in patients undergoing office-based endometrial biopsy. We conducted a prospective, randomised (lidocaine spray (n = 60) and placebo (n = 60), respectively), double-blind study. The mean pain score during procedure was 3.51 ± 1.51 in the lidocaine spray group and 5.11 ± 1.66 in the placebo group. Lidocaine spray treatment significantly lowered the pain scores compared with placebo (p < 0.001). Lidocaine spray can be accepted as a non-invasive, easy to apply and more comfortable anaesthetic method for office-based endometrial sampling.
authors.affiliation: a Kayseri Military Hospital , Department of Obstetrics and Gynaecology , Kayseri , Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Aksoy
authors.affiliation: b Kayseri Education and Training Hospital , Department of Obstetrics and Gynaecology , Kayseri , Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Aksoy
authors.affiliation: b Kayseri Education and Training Hospital , Department of Obstetrics and Gynaecology , Kayseri , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ozyurt
authors.affiliation: b Kayseri Education and Training Hospital , Department of Obstetrics and Gynaecology , Kayseri , Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Acmaz
authors.affiliation: c Gulhane Military Medical Academy , Department of Public Health , Kayseri , Turkey.
authors.forename: M A
authors.initials: MA
authors.lastname: Babayigit
authors.affiliation: d Acibadem Hospital , Department of Obstetrics and Gynaecology , Kayseri , Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Yücel
authors.affiliation: d Acibadem Hospital , Department of Obstetrics and Gynaecology , Kayseri , Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Aydin
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001706:Biopsy / Q000009:adverse effects; D004311:Double-Blind Method; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine
keywords: Endometrial biopsy; analgesia; lidocaine spray