title: Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored.
abstract: Guillain-Barré syndrome (GBS), the axonal subtype of which is mainly triggered by C. jejuni with ganglioside-mimicking lipooligosaccharides (LOS), is an immune-mediated disorder in the peripheral nervous system (PNS) accompanied by the disruption of the blood-nerve barrier (BNB) and the blood-cerebrospinal fluid barrier (B-CSF-B). Biomarkers of GBS have been extensively explored and some of them are proved to assist in the clinical diagnosis and in monitoring disease progression as well as in assessing the efficacy of immunotherapy. Herein, we systemically review the literature on biomarkers of GBS, including infection-/immune-/BNB, B-CSF-B, and PNS damage-associated biomarkers, aiming at providing an overview of GBS biomarkers and guiding further investigations. Furthermore, we point out further directions for studies on GBS biomarkers.
authors.affiliation: Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun 130000, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Heilongjiang Provincial Hospital, Harbin, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Sun
authors.affiliation: Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun 130000, China ; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun 130000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cui
authors.affiliation: Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun 130000, China ; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D020275:Guillain-Barre Syndrome / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological
chemical_list: D015415:Biomarkers