title: Palladium(II)-Catalyzed Acetoxime Directed ortho-Arylation of Aromatic Alcohols.
abstract: Biaryls, which contained a benzyloxy motif, were directly constructed through a ligand-promoted Pd(II) -catalyzed ortho-arylation of masked aromatic alcohols. A variety of acetoxime ethers could be coupled with a diverse range of arylboronic acid pinocol esters, giving direct access to bioactive biaryls in modest to good yield. Not only could acetoxime be subsequently removed without a separation, functionalized hydroxylamine derivatives could also be obtained.
authors.affiliation: Key Laboratory of Organic Synthesis, Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (P. R. China).
authors.forename: Kun
authors.initials: K
authors.lastname: Guo
authors.affiliation: Key Laboratory of Organic Synthesis, Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (P. R. China).
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Chen
authors.affiliation: College of Physics, Optoelectronics and Energy & Collaborative Innovation Center, Suzhou Nano Science and Technology, Soochow University, Suzhou 215006 (P. R. China).
authors.forename: Jingyu
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Organic Synthesis, Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (P. R. China). yszhao@suda.edu.cn.
authors.forename: Yingsheng
authors.initials: Y
authors.lastname: Zhao
keywords: CH activation; alcohols; arylation; cross-coupling; synthetic methods