title: [Oxidative stress and preeclampsia: A review].
abstract: Preeclampsia is a leading cause of pregnancy complications and affects 3-7% of pregnant women. Pathophysiology of preeclampsia is still unclear. According to the two-stage model of preeclampsia, the abnormal and hypoperfused placenta (stage 1) releases factors to the bloodstream, which are responsible for the maternal symptoms (stage 2), characterised by a systemic inflammation and endothelial dysfunction. Oxidative stress plays an important role in the pathophysiology of the preeclampsia and could be the common denominator between the two. This review summarizes the current knowledge of a new potential etiology of the disease, with a special focus on oxidative stress. We also review the different factors that have been proposed to cause endothelial cell dysfunction in preeclampsia, and trials investigating the role of antioxidant supplementation in preeclampsia.
authors.affiliation: Pôle de gynécologie obstétrique, hôpital Paule-de-Viguier, CHU de Toulouse, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 9, France. Electronic address: paul.guerby@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Guerby
authors.affiliation: Pôle de gynécologie obstétrique, hôpital Paule-de-Viguier, CHU de Toulouse, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 9, France.
authors.forename: F
authors.initials: F
authors.lastname: Vidal
authors.affiliation: Inserm UMR-1048, université de Toulouse, BP 84225, 31432 Toulouse cedex 4, France.
authors.forename: S
authors.initials: S
authors.lastname: Garoby-Salom
authors.affiliation: Pôle de gynécologie obstétrique, hôpital Paule-de-Viguier, CHU de Toulouse, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 9, France; Université de Toulouse III, UMR1027, 31073 Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Vayssiere
authors.affiliation: Inserm UMR-1048, université de Toulouse, BP 84225, 31432 Toulouse cedex 4, France.
authors.forename: R
authors.initials: R
authors.lastname: Salvayre
authors.affiliation: Pôle de gynécologie obstétrique, hôpital Paule-de-Viguier, CHU de Toulouse, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 9, France; Université de Toulouse III, UMR1027, 31073 Toulouse, France.
authors.forename: O
authors.initials: O
authors.lastname: Parant
authors.affiliation: Pôle de gynécologie obstétrique, hôpital Paule-de-Viguier, CHU de Toulouse, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 9, France.
authors.forename: A
authors.initials: A
authors.lastname: Negre-Salvayre
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage; D019587:Dietary Supplements; D004727:Endothelium / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy
chemical_list: D000975:Antioxidants
keywords: Antioxidant; Antioxydant; Oxidative stress; Pathophysiology; Physiopathologie; Placenta; Preeclampsia; Pré-éclampsie; Stress oxydant