title: Restoring inflammatory balance as a potential preventive strategy for inflammation induced cancer.
abstract: In contrast to the accepted notion that tumor-derived signals polarize macrophages toward a protumorigenic M2 phenotype during tumor progression, we recently discovered that the inflammatory microenvironment is capable of driving macrophages toward an M2 phenotype. Moreover, our data suggests that inflammatory education is prominent during the early phases of hepatocellular carcinoma (HCC) suggesting that inflammatory modulation might effectively prevent HCC.
authors.affiliation: Department of Immunology and Cancer Research; Institute for Medical Research Israel Canada (IMRIC); Hebrew University-Hadassah Medical School ; Jerusalem, Israel.
authors.forename: Simona
authors.initials: S
authors.lastname: Hefetz-Sela
authors.affiliation: Department of Immunology and Cancer Research; Institute for Medical Research Israel Canada (IMRIC); Hebrew University-Hadassah Medical School ; Jerusalem, Israel ; Department of Pathology; Hadassah-Hebrew University Medical Center ; Jerusalem, Israel.
authors.forename: Ilan
authors.initials: I
authors.lastname: Stein
authors.affiliation: Department of Immunology and Cancer Research; Institute for Medical Research Israel Canada (IMRIC); Hebrew University-Hadassah Medical School ; Jerusalem, Israel ; Department of Pathology; Hadassah-Hebrew University Medical Center ; Jerusalem, Israel.
authors.forename: Eli
authors.initials: E
authors.lastname: Pikarsky
keywords: c-Jun phosphorylation; hepatocellular carcinoma; immune check point drugs; inflammation-induced cancer; macrophage polarization