title: The Role of I-123 Metaiodobenzylguanidine Imaging in Management of Patients With Heart Failure.
abstract: Despite advances in evidence-based treatments, the morbidity and mortality of congestive heart failure remain exceedingly high. In addition, the costs associated with recurrent hospitalizations and advanced therapies, such as implantable cardiac defibrillators (ICDs), left ventricular assist devices, and heart transplantation, place a substantial financial burden on the health care system. The present criteria for risk stratification in patients with heart failure are inadequate and often prevent the allocation of appropriate treatment. Patients who have received ICDs as primary prevention for sudden cardiac death often receive no device therapy in their lifetime, whereas other patients with left ventricular dysfunction die suddenly without meeting criteria for ICD implantation.
authors.affiliation: Nuclear Cardiology, Cardiac Rehabilitation, Cleveland Clinic Florida, Weston, Florida. Electronic address: cfarnum@magellanhealth.com.
authors.forename: David
authors.initials: D
authors.lastname: Wolinsky
authors.affiliation: Cardiac Care Unit, University of Miami Hospital, Miami, Florida; Cardiac Imaging and Outpatient Services, Cardiovascular Division, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Robert
authors.initials: R
authors.lastname: Hendel
authors.affiliation: Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio; Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Manuel
authors.initials: M
authors.lastname: Cerqueira
authors.affiliation: Division of Cardiology, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Michael
authors.initials: M
authors.lastname: Gold
authors.affiliation: Cardiovascular Imaging Program, Mount Sinai School of Medicine, New York, New York; Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York; Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York.
authors.forename: Jagat
authors.initials: J
authors.lastname: Narula
authors.affiliation: Harvard Medical School, Heart Center, Massachusetts General Hospital, Boston, Massachusetts; Resynchronization and Advanced Cardiac Therapeutics Program, Heart Center, Massachusetts General Hospital, Boston, Massachusetts; Coronary Venous Angiography Core Laboratory, Heart Center, Massachusetts General Hospital, Boston, Massachusetts; Holter Laboratory, Heart Center, Massachusetts General Hospital, Boston, Massachusetts; Cardiac Arrhythmia Service, Heart Center, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Jagmeet
authors.initials: J
authors.lastname: Singh
authors.affiliation: Emory University, Atlanta, Georgia.
authors.forename: Leslee
authors.initials: L
authors.lastname: Shaw
authors.affiliation: Memorial Care Heart and Vascular Institute, Long Beach Memorial, Long Beach, California; University of California, Irvine, California.
authors.forename: Gregory
authors.initials: G
authors.lastname: Thomas
authors.affiliation: Cleveland Clinic, Cleveland, Ohio.
authors.forename: Oussama
authors.initials: O
authors.lastname: Wazni
authors.affiliation: Chronic Disease Management Incorporated, LLC, Newport, Rhode Island.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Farnum
mesh_terms: D019797:3-Iodobenzylguanidine; D001145:Arrhythmias, Cardiac / Q000000981:diagnostic imaging* / Q000628:therapy; D032921:Consensus; D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D019468:Disease Management; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation; D006333:Heart Failure / Q000000981:diagnostic imaging*; D006353:Heart-Assist Devices; D006801:Humans; D007457:Iodine Radioisotopes; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D018570:Risk Assessment; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000628:therapy
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine