title: Deep brain stimulation complicated by bilateral large cystic cavitation around the leads in a patient with Parkinson's disease.
abstract: Deep brain stimulation (DBS) is an approved and effective therapy for patients suffering from advanced Parkinson's disease (PD). Several clinical trials have indicated significant motor function improvement in patients undergoing subthalamic nucleus stimulation. This therapy is, rarely, associated with complications, mostly related to infections, seizures or stimulation-induced side effects. We report a case of a 71-year-old man with a 10-year history of PD who underwent bilateral placement of subthalamic nucleus DBS. As a complication, the patient showed subjective postoperative cognitive decline, and subsequent MRI showed peri-lead oedema, which progressed to large cystic cavitation around the leads without indication of infection. The patient received steroid therapy and the cavitations regressed without surgical intervention.
authors.affiliation: Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Jagid
authors.affiliation: Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Karthik
authors.initials: K
authors.lastname: Madhavan
authors.affiliation: Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Amade
authors.initials: A
authors.lastname: Bregy
authors.affiliation: Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Mehul
authors.initials: M
authors.lastname: Desai
authors.affiliation: Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Armando
authors.initials: A
authors.lastname: Ruiz
authors.affiliation: Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Quencer
authors.affiliation: Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Landy
mesh_terms: D000368:Aged; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology; D003560:Cysts / Q000209:etiology* / Q000473:pathology; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D004487:Edema / Q000209:etiology; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*