title: Procedural Results and Clinical Outcomes of Transcatheter Aortic Valve Implantation in Switzerland: An Observational Cohort Study of Sapien 3 Versus Sapien XT Transcatheter Heart Valves.
abstract: BACKGROUND
  New generation transcatheter heart valves (THV) may improve clinical outcomes of transcatheter aortic valve implantation.
  
  
  RESULTS
  In a nationwide, prospective, multicenter cohort study (Swiss Transcatheter Aortic Valve Implantation Registry, NCT01368250), outcomes of consecutive transfemoral transcatheter aortic valve implantation patients treated with the Sapien 3 THV (S3) versus the Sapien XT THV (XT) were investigated. An overall of 153 consecutive S3 patients were compared with 445 consecutive XT patients. Postprocedural mean transprosthetic gradient (6.5±3.0 versus 7.8±6.3 mm Hg, P=0.17) did not differ between S3 and XT patients, respectively. The rate of more than mild paravalvular regurgitation (1.3% versus 5.3%, P=0.04) and of vascular (5.3% versus 16.9%, P<0.01) complications were significantly lower in S3 patients. A higher rate of new permanent pacemaker implantations was observed in patients receiving the S3 valve (17.0% versus 11.0%, P=0.01). There were no significant differences for disabling stroke (S3 1.3% versus XT 3.1%, P=0.29) and all-cause mortality (S3 3.3% versus XT 4.5%, P=0.27).
  
  
  CONCLUSIONS
  The use of the new generation S3 balloon-expandable THV reduced the risk of more than mild paravalvular regurgitation and vascular complications but was associated with an increased permanent pacemaker rate compared with the XT. Transcatheter aortic valve implantation using the newest generation balloon-expandable THV is associated with a low risk of stroke and favorable clinical outcomes.
  
  
  BACKGROUND
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT01368250.
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Binder
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Stefan
authors.initials: S
authors.lastname: Stortecky
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Dik
authors.initials: D
authors.lastname: Heg
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: David
authors.initials: D
authors.lastname: Tueller
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Raban
authors.initials: R
authors.lastname: Jeger
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Stefan
authors.initials: S
authors.lastname: Toggweiler
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pedrazzini
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Franz W
authors.initials: FW
authors.lastname: Amann
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Enrico
authors.initials: E
authors.lastname: Ferrari
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Stephane
authors.initials: S
authors.lastname: Noble
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Fabian
authors.initials: F
authors.lastname: Nietlispach
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Francesco
authors.initials: F
authors.lastname: Maisano
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Lorenz
authors.initials: L
authors.lastname: Räber
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Marco
authors.initials: M
authors.lastname: Roffi
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Jürg
authors.initials: J
authors.lastname: Grünenfelder
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Peter
authors.initials: P
authors.lastname: Jüni
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Christoph
authors.initials: C
authors.lastname: Huber
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.).
authors.forename: Stephan
authors.initials: S
authors.lastname: Windecker
authors.affiliation: From the Department of Cardiology and Department of Cardiovascular Surgery, University Heart Centre Zurich, University Hospital Zurich, Zurich, Switzerland (R.K.B., F.N., F.M.); Department of Cardiology and Department of Cardiovascular Surgery, Swiss Cardiovascular Centre, Bern University Hospital, Bern, Switzerland (S.S., L.R., C.H., S.W., P.W.); Department of Clinical Research, Clinical Trials Unit and Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland (D.H., P.J.); Triemli Hospital Zurich, Zurich, Switzerland (D.T.); Department of Cardiology and Department of Cardiovascular Surgery, Basel University Hospital, University of Basel, Basel, Switzerland (R.J.); Cantonal Hospital Lucerne, Lucerne, Switzerland (S.T.); Department of Cardiology, Cardiocentro Ticino, Lugano, Switzerland (G.P.); Department of Cardiology, Klinik im Park, Hirslanden Clinic Zurich, Zurich, Switzerland (F.W.A.); Department of Cardiothoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland (E.F.); Department of Cardiology, Geneva University Hospital, Geneva, Switzerland (S.N., M.R.); and Heart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland (J.G.). peter.wenaweser@insel.ch.
authors.forename: Peter
authors.initials: P
authors.lastname: Wenaweser
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D001021:Aortic Valve / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000453:epidemiology / Q000601:surgery; D015331:Cohort Studies; D006350:Heart Valve Prosthesis / Q000009:adverse effects / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D011446:Prospective Studies; D012306:Risk; D013557:Switzerland; D065467:Transcatheter Aortic Valve Replacement; D016896:Treatment Outcome
keywords: aortic valve stenosis; bleeding; transcatheter aortic valve replacement; transcatheter heart valve; transcutaneous aortic valve implantation; vascular complications