title: Correlation Between Subacute Sensorimotor Deficits and Brain Edema in Rats after Surgical Brain Injury.
abstract: No matter how carefully a neurosurgical procedure is performed, it is intrinsically linked to postoperative deficits resulting in delayed healing caused by direct trauma, hemorrhage, and brain edema, termed surgical brain injury (SBI). Cerebral edema occurs several hours after SBI and is a major contributor to patient morbidity, resulting in increased postoperative care. Currently, the correlation between functional recovery and brain edema after SBI remains unknown. Here we examine the correlation between neurological function and brain water content in rats 42 h after SBI. SBI was induced in male Sprague-Dawley rats via frontal lobectomy. Twenty-four hours post-ictus animals were subjected to four neurobehavior tests: composite Garcia neuroscore, beam walking test, corner turn test, and beam balance test. Animals were then sacrificed for right-frontal brain water content measurement via the wet-dry method. Right-frontal lobe brain water content was found to significantly correlate with neurobehavioral deficits in the corner turn and beam balance tests: the number of left turns (percentage of total turns) for the corner turn test and distance traveled for the beam balance test were both inversely proportional with brain water content. No correlation was observed for the composite Garcia neuroscore or the beam walking test.
authors.affiliation: Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Devin W
authors.initials: DW
authors.lastname: McBride
authors.affiliation: Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Yuechun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Loic
authors.initials: L
authors.lastname: Adam
authors.affiliation: Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Oudin
authors.affiliation: Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Louis
authors.affiliation: Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
authors.forename: Jiping
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA. jhzhang@llu.edu.|Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USA. jhzhang@llu.edu.
authors.forename: John H
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001929:Brain Edema / Q000209:etiology / Q000503:physiopathology*; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology*; D004195:Disease Models, Animal; D018450:Disease Progression; D005625:Frontal Lobe / Q000601:surgery; D007431:Intraoperative Complications; D008297:Male; D019635:Neurosurgical Procedures; D051381:Rats; D017207:Rats, Sprague-Dawley; D012678:Sensation Disorders / Q000209:etiology / Q000503:physiopathology
keywords: Brain edema; Functional test; Neurobehavior; SBI; Sensorimotor; Surgical brain injury