title: Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid sponge.
abstract: Two new bromotyrosine alkaloids, tyrokeradines G (1) and H (2), have been isolated from an Okinawan marine sponge of the order Verongida. The structures of 1 and 2 were elucidated on the basis of spectroscopic data. Tyrokeradine G (1) is the first bromotyrosine alkaloid possessing a β-alanine unit, while tyrokeradine H (2) is a rare bromotyrosine alkaloid possessing a N-substituted pyridinium ring. Tyrokeradines G (1) and H (2) showed antifungal activity.
authors.affiliation: Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan; Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. Electronic address: kubota@ac.shoyaku.ac.jp.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Watase
authors.affiliation: Medical Mycology Research Center, Chiba University, Chiba 260-0856, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Western Australian Museum, Locked Bag 49, Welshpool DC, WA 6986, Australia.
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.affiliation: Medical Mycology Research Center, Chiba University, Chiba 260-0856, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. Electronic address: jkobay@pharm.hokudai.ac.jp.
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D011161:Porifera; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; C000608568:tyrokeradine G; C000608569:tyrokeradine H; D014443:Tyrosine
keywords: Antifungal activity; Bromotyrosine alkaloid; Marine sponge; Order Verongida