title: Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma.
abstract: Oral squamous cell carcinoma (OSCC) is one of the most lethal malignant tumors. The cadherin/catenin cell-cell adhesion complex plays a major role in cancer development and progression. p120-catenin (p120) is a cytoplasmic molecule closely associated with E-cadherin which activates phospholipase C-γ1 (PLC-γ1). Our previous studies indicate that activation of PLC-γ1 plays a critical role in epidermal growth factor (EGF)-induced migration and proliferation of squamous cell carcinoma (SCC) cells and phosphatidylinositol 3-kinase enhancer (PIKE) is highly expressed in SCC cells and mediates EGFR-dependent SCC cell proliferation. Our current study was to determine whether the expression of E-cadherin, p120, PLC-γ1, and PIKE, is associated with OSCC. To address this issue, we assessed levels and localization of E-cadherin, p120, PLC-γ1, and PIKE in specimen of 92 patients with OSCC by immunohistochemistry. The results showed that the expression of E-cadherin, and p120 negatively correlated with the tumor differentiation and the expression of PLC-γ1 and PIKE positively correlated with the tumor differentiation. The expression of PLC-γ1 and PIKE in OSCC stage T3 + T4 or in OSCC with lymph node metastasis was significantly higher than that in OSCC stage T1 + T2 or in OSCC without lymph node metastasis. The expression of p120 positively correlated with levels of E-cadherin but negatively correlated with levels of PLC-γ1 and PIKE in OSCC. These data indicate that increased expression of PLC-γ1 and PIKE and decreased expression of E-cadherin and p120 are associated with the aggressiveness of OSCC.
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Liao
authors.affiliation: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Chandrama
authors.initials: C
authors.lastname: Shrestha
authors.affiliation: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Shangli
authors.initials: S
authors.lastname: Ji
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Peng
authors.affiliation: Department of Pathology, Children's Hospital Los Angeles, University of Southern California Los Angeles, CA 90027, USA.
authors.forename: Larry
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Eryuan
authors.initials: E
authors.lastname: Liao
authors.affiliation: Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Zhongjian
authors.initials: Z
authors.lastname: Xie
mesh_terms: D000328:Adult; D015820:Cadherins / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D051177:Catenins / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D019204:GTP-Binding Proteins / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000473:pathology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051966:Phospholipase C gamma / Q000378:metabolism*; D015854:Up-Regulation; D000095002:Delta Catenin
chemical_list: D015820:Cadherins; D051177:Catenins; D020690:GTPase-Activating Proteins; D019869:Phosphatidylinositol 3-Kinases; D051966:Phospholipase C gamma; C485997:AGAP2 protein, human; D019204:GTP-Binding Proteins; D000095002:Delta Catenin; C000722347:CTNND1 protein, human
keywords: E-cadherin; OSCC; PIKE; PLC-γ1; p120