title: Evaluation of the relationship between clinical variables and thromboelastographic findings in dogs with protein-losing nephropathy.
abstract: OBJECTIVE
  To determine whether hypercoagulability in proteinuric dogs, defined by thromboelastography (TEG), is related to the degree of proteinuria, presence of systemic arterial hypertension, presence of hypoalbuminemia, or reduced antithrombin activity.
  
  
  METHODS
  Prospective study of client-owned dogs. Data collected from each patient included signalment, body weight, urine protein-to-creatinine ratio (UPC), serum albumin concentration, TEG values, noninvasive arterial blood pressure, and AT activity. Hypercoagulability was diagnosed by TEG and odds ratios for other measurements were assessed by univariate logistic regression.
  
  
  METHODS
  Urban referral center and teaching hospital.
  
  
  METHODS
  Seventy-six dogs with protein-losing nephropathy (PLN) based on UPC, diagnosed between Oct 2009 and Oct 2012.
  
  
  METHODS
  None.
  
  
  RESULTS
  The prevalence of hypercoagulability was 89%. No statistically significant associations were detected between hypercoagulability and UPC, serum albumin, noninvasive blood pressure, or AT activity (all P > 0.05). The prevalence of thromboembolism was 6.6%.
  
  
  CONCLUSIONS
  Hypercoagulability was prevalent in dogs with PLN but could not be predicted based upon the presence or degree of proteinuria, systemic arterial hypertension, hypoalbuminemia, or low AT activity. The prevalance of thromboembolism was low in this population with PLN.
authors.affiliation: Departments of Medicine, Bobst Hospital of The Animal Medical Center, New York City, NY, 10065.
authors.forename: Carrie R
authors.initials: CR
authors.lastname: White
authors.affiliation: Departments of Medicine, Bobst Hospital of The Animal Medical Center, New York City, NY, 10065.
authors.forename: Cathy
authors.initials: C
authors.lastname: Langston
authors.affiliation: Departments of Medicine, Bobst Hospital of The Animal Medical Center, New York City, NY, 10065.
authors.forename: Ann E
authors.initials: AE
authors.lastname: Hohenhaus
authors.affiliation: Lamb Consulting, West Saint Paul, MN, 55118.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Lamb
authors.affiliation: Emergency and Critical Care, Bobst Hospital of The Animal Medical Center, New York City, NY, 10065.
authors.forename: Susan
authors.initials: S
authors.lastname: Hackner
authors.affiliation: Departments of Medicine, Bobst Hospital of The Animal Medical Center, New York City, NY, 10065.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Fox
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests / Q000662:veterinary*; D001794:Blood Pressure; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs; D007674:Kidney Diseases / Q000662:veterinary; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D011507:Proteinuria / Q000662:veterinary; D013916:Thrombelastography; D019851:Thrombophilia
keywords: antithrombin; blood pressure; kidney; thromboembolism