title: Effect of Heparin on Contractile Activity of Lymph Node Capsule.
abstract: Experiments on smooth muscle strips isolated from the capsule of bovine mesenteric lymph node showed that heparin low concentrations (0.010-0.025 U/ml) stimulating spontaneous isometric phasic contractions of smooth muscles, but higher heparin concentrations reduced or even completely eliminated these contractions. The inhibitory effects of heparin were presumably realized via stimulation of NO production by endothelial cells of the subcapsular space followed by activation of ATP-sensitive potassium channels of capsular myocytes and via modulation of prostaglandin synthesis.
authors.affiliation: Laboratory of Cardiovascular and Lymph System Physiology, I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Pan'kova
authors.affiliation: Laboratory of Cardiovascular and Lymph System Physiology, I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences, St. Petersburg, Russia. gilobov@yandex.ru.
authors.forename: G I
authors.initials: GI
authors.lastname: Lobov
mesh_terms: D000818:Animals; D002417:Cattle; D004558:Electric Stimulation; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005905:Glyburide / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology*; D059165:Hormesis; D007213:Indomethacin / Q000494:pharmacology; D007537:Isometric Contraction / Q000187:drug effects* / Q000502:physiology; D054086:KATP Channels / Q000819:agonists / Q000378:metabolism; D008198:Lymph Nodes / Q000187:drug effects; D008643:Mesentery / Q000187:drug effects; D008751:Methylene Blue / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000819:agonists / Q000096:biosynthesis; D046509:Tissue Culture Techniques
chemical_list: D054086:KATP Channels; D009569:Nitric Oxide; D006493:Heparin; D005905:Glyburide; D008751:Methylene Blue; D019331:NG-Nitroarginine Methyl Ester; D007213:Indomethacin
keywords: contractility; endotheliocytes; heparin; lymph nodes; smooth muscles