title: Synthesis of novel compounds containing morpholine and 5(4H)-oxazolone rings as potent tyrosinase inhibitors.
abstract: In this study, six new compounds containing morpholine and 5(4H)-oxazolone rings were synthesized. Structures of the new compounds using IR, (1)H NMR, mass spectroscopy and elemental analysis were characterized. All new compounds (4a-4f) have a strong inhibitory effect against mushroom tyrosinase. And the inhibitory effects of these compounds were compared with Kojic acid as standard.
authors.affiliation: Department of Chemistry, Payame Noor University (PNU), PO Box 19395-3697, Tehran, Iran. Electronic address: h_hamidian@pnu.ac.ir.
authors.forename: Hooshang
authors.initials: H
authors.lastname: Hamidian
authors.affiliation: Department of Chemistry, Payame Noor University (PNU), PO Box 19395-3697, Tehran, Iran.
authors.forename: Sima
authors.initials: S
authors.lastname: Azizi
mesh_terms: D000363:Agaricales / Q000201:enzymology; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008543:Melanins / Q000378:metabolism; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009025:Morpholines / Q000737:chemistry*; D010081:Oxazolone / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D011753:Pyrones / Q000737:chemistry / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D004791:Enzyme Inhibitors; D008543:Melanins; D009025:Morpholines; D011753:Pyrones; D010081:Oxazolone; C011890:kojic acid; C037574:morpholine; D014442:Monophenol Monooxygenase
keywords: 5(4H)-Oxazolone; Morpholine; Synthesis; Tyrosinase inhibitor