title: Association of chemerin Rs17173608 and vaspin Rs2236242 gene polymorphisms with metabolic syndrome in Egyptian women.
abstract: OBJECTIVE
  The metabolic syndrome is a complex of interrelated risk factors for cardiovascular disease and diabetes. The adipokines, chemerin and vaspin, are known to have metabolic regulatory roles. This study aimed to assess the relation of chemerin rs17173608 and vaspin rs2236242 polymorphisms with metabolic syndrome and its related phenotypes in Egyptian women.
  
  
  METHODS
  The study included 100 healthy female subjects and 100 metabolic syndrome patients. The component traits of metabolic syndrome were determined and the genotypes of the polymorphisms were assessed using the tetra amplification refractory mutation system polymerase chain reaction procedure.
  
  
  RESULTS
  The minor G allele of the chemerin rs17173608 polymorphism had a significantly higher frequency in metabolic syndrome patients (p = 0.0001). The component traits of metabolic syndrome were significantly increased in the carriers of the GG and TG genotypes. In contrast, the rare A allele of vaspin rs2236242 polymorphism was significantly higher in the control subjects (p = 0.005). The carriers of the TA and AA genotypes showed significant relation with lower values of the phenotypes of metabolic syndrome.
  
  
  CONCLUSIONS
  Metabolic syndrome in Egyptian females is associated with the minor allele of chemerin rs17173608 polymorphism, whereas the minor allele of vaspin rs2236242 polymorphism plays a protective role against metabolic syndrome.
authors.affiliation: a Department of Biochemistry, Faculty of Pharmacy, Suez Canal University , Ismailia , Egypt and.
authors.forename: Eman T
authors.initials: ET
authors.lastname: Mehanna
authors.affiliation: a Department of Biochemistry, Faculty of Pharmacy, Suez Canal University , Ismailia , Egypt and.
authors.forename: Noha M
authors.initials: NM
authors.lastname: Mesbah
authors.affiliation: b Department of Medical Biochemistry, Faculty of Medicine, Port Said University , Port Said , Egypt.
authors.forename: Maivel H
authors.initials: MH
authors.lastname: Ghattas
authors.affiliation: a Department of Biochemistry, Faculty of Pharmacy, Suez Canal University , Ismailia , Egypt and.
authors.forename: Samy M
authors.initials: SM
authors.lastname: Saleh
authors.affiliation: a Department of Biochemistry, Faculty of Pharmacy, Suez Canal University , Ismailia , Egypt and.
authors.forename: Dina M
authors.initials: DM
authors.lastname: Abo-Elmatty
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D018925:Chemokines / Q000235:genetics*; D003430:Cross-Sectional Studies; D004534:Egypt; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D015843:Serpins / Q000235:genetics*
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; C507339:SERPINA12 protein, human; D015843:Serpins
keywords: Adipokines; chemerin rs17173608; metabolic syndrome; polymorphism; vaspin rs2236242