title: Hypervalent Iodine-Mediated Intramolecular trans-Aminocarboxylation and Oxoaminocarboxylation of Alkynes: Divergent Cascade Annulations of Isocoumarins under Metal-Free Conditions.
abstract: An exclusive trans-aminocarboxylation and oxoaminocarboxylation of diarylalkynes were realized through hypervalent iodine-mediated cascade annulations under metal-free conditions, leading to divergent assembly of fused or spiro polycyclic heterocycles with a dosage of the hypervalent iodine oxidant. The mechanisms for the formation of both products are proposed.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, P. R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, P. R. China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Hou
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, P. R. China.
authors.forename: Daisy
authors.initials: D
authors.lastname: Zhang-Negrerie
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, P. R. China.
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, P. R. China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Du
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D049934:Isocoumarins / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D006576:Heterocyclic Compounds, 4 or More Rings; D049934:Isocoumarins; D058116:Lewis Acids; D013141:Spiro Compounds; D007455:Iodine