title: Myosin superfamily: The multi-functional and irreplaceable factors in spermatogenesis and testicular tumors.
abstract: Spermatogenesis is a fundamental process in sexual development and reproduction, in which the diploid spermatogonia transform into haploid mature spermatozoa. This process is under the regulation of multiple factors and pathway. Myosin has been implicated in various aspects during spermatogenesis. Myosins constitute a diverse superfamily of actin-based molecular motors that translocate along microfilament in an ATP-dependent manner, and six kinds of myosins have been proved that function during spermatogenesis. In mitosis and meiosis, myosins play an important role in spindle assembly and positioning, karyokinesis and cytokinesis. During spermiogenesis, myosins participate in acrosomal formation, nuclear morphogenesis, mitochondrial translocation and spermatid individualization. In this review, we summarize current understanding of the functions of myosin in spermatogenesis and some reproductive system diseases such as testicular tumors and prostate cancer, and discuss the roles of possible upstream molecules which regulate myosin in these processes.
authors.affiliation: The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Yan-Ruide
authors.initials: YR
authors.lastname: Li
authors.affiliation: The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wxyang@spermlab.org.
authors.forename: Wan-Xi
authors.initials: WX
authors.lastname: Yang
mesh_terms: D000177:Acrosome / Q000378:metabolism; D048749:Cytokinesis; D006801:Humans; D008297:Male; D008540:Meiosis; D008938:Mitosis; D009218:Myosins / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism; D012708:Sertoli Cells / Q000378:metabolism; D015398:Signal Transduction; D013087:Spermatids / Q000378:metabolism; D013091:Spermatogenesis / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism; D013736:Testicular Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D009218:Myosins
keywords: Acroframosome; Mitosis; Myosin; Reproductive system diseases; Spermatogenesis