title: Secondary Hemophagocytic Lymphohistiocytosis in a Patient With Favorable Histology Wilms Tumor.
abstract: Secondary hemophagocytic lymphohistiocytosis (HLH) is most commonly associated with malignancy, infection, or an underlying autoimmune disorder. Malignancy-associated hemophagocytic syndrome is responsible for most secondary HLH cases, but it has not been well described in children. We present a case of a 4-year-old female with favorable histology of Wilms tumor who developed secondary HLH after unsuccessful resection of the tumor and initiation of chemotherapy.
authors.affiliation: Departments of *Pediatrics †Pathology, University of California San Diego, San Diego, CA.
authors.forename: Erin P
authors.initials: EP
authors.lastname: Murphy
authors.forename: Jun
authors.initials: J
authors.lastname: Mo
authors.forename: Janet M
authors.initials: JM
authors.lastname: Yoon
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D020360:Neoadjuvant Therapy; D009392:Nephrectomy; D012074:Remission Induction; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000556:secondary / Q000601:surgery
chemical_list: D016756:Immunoglobulins, Intravenous; D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003907:Dexamethasone; D004317:Doxorubicin