title: Does collateral retrospective information about childhood attention-deficit/hyperactivity disorder symptoms assist in the diagnosis of attention-deficit/hyperactivity disorder in adults? Findings from a large clinical sample.
abstract: OBJECTIVE
  In accordance with consolidated clinical practice, Diagnostic and Statistical Manual of Mental Disorders, 5th edition suggests a key role of collateral information in the evaluation of retrospective childhood attention-deficit/hyperactivity disorder symptoms in adults despite poor evidence supporting its use. This study aims to assess the incremental value of collateral information on the presence of childhood attention-deficit/hyperactivity disorder symptoms when evaluating adults with attention-deficit/hyperactivity disorder.
  
  
  METHODS
  Adult patients with attention-deficit/hyperactivity disorder (n = 449) and non-attention-deficit/hyperactivity disorder subjects (n = 143) underwent an extensive clinical assessment based on Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria. For patients, retrospective collateral information regarding childhood attention-deficit/hyperactivity disorder was obtained and used to sort them into two groups: agreement (n = 277) and disagreement (n = 172) between self- and collateral reports. We compared demographic, clinical and response to treatment profiles among groups to test the relevance of collateral information on the specific issue of childhood attention-deficit/hyperactivity disorder symptoms.
  
  
  RESULTS
  Both attention-deficit/hyperactivity disorder groups had higher rates of several comorbidities (oppositional defiant, conduct, substance use and bipolar disorders; all p < 0.001) and impairments than controls. Disagreement between self- and collateral reports on childhood attention-deficit/hyperactivity disorder symptoms occurred in 38% of patients. Overall, attention-deficit/hyperactivity disorder disagreement and agreement groups had similar profiles in response to treatment and comorbidity, and the few differences detected in impairment measures were of small magnitude (Eta(2) < 0.05).
  
  
  CONCLUSIONS
  Although collateral report has an important role for diagnosing attention-deficit/hyperactivity disorder in children, it has no incremental value in the evaluation of childhood attention-deficit/hyperactivity disorder symptoms in adults with a self-reported history of attention-deficit/hyperactivity disorder assessed in clinical settings.
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Vitor
authors.initials: V
authors.lastname: Breda
authors.affiliation: Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Diego Luiz
authors.initials: DL
authors.lastname: Rovaris
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Eduardo Schneider
authors.initials: ES
authors.lastname: Vitola
authors.affiliation: Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Nina Roth
authors.initials: NR
authors.lastname: Mota
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Paula
authors.initials: P
authors.lastname: Blaya-Rocha
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Carlos Alberto Iglesias
authors.initials: CA
authors.lastname: Salgado
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Marcelo Moraes
authors.initials: MM
authors.lastname: Victor
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Felipe Almeida
authors.initials: FA
authors.lastname: Picon
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Rafael Gomes
authors.initials: RG
authors.lastname: Karam
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Katiane Lilian
authors.initials: KL
authors.lastname: Silva
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Department of Psychiatry, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Luis Augusto
authors.initials: LA
authors.lastname: Rohde
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Claiton Henrique Dotto
authors.initials: CH
authors.lastname: Bau
authors.affiliation: ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Department of Psychiatry, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil eugenio.grevet@ufrgs.br.
authors.forename: Eugenio Horacio
authors.initials: EH
authors.lastname: Grevet
mesh_terms: D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000188:drug therapy*; D001938:Brazil; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D015897:Comorbidity; D003710:Demography; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D012189:Retrospective Studies; D057566:Self Report; D012720:Severity of Illness Index
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate
keywords: Adult ADHD; childhood symptoms; collaterals; informant report; third party information