title: Tropheryma whipplei in children with diarrhoea in rural Ghana.
abstract: Tropheryma whipplei has been hypothesized to be able to cause diarrhoea, but data from young children are scarce. In this hospital-based case-control study 534 stool samples of children aged between 2 months and 15 years from rural Ghana were analysed for the presence of T. whipplei. Overall stool prevalence of T. whipplei was high (27.5%). Although there was no difference in T. whipplei carriage overall between cases and controls, cases aged between 0 and 12 months carried T. whipplei in their stool twice as often as controls without diarrhoea. The results from this study may support the hypothesis that T. whipplei can cause diarrhoea in first-time infection.
authors.affiliation: I. Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany; Clinical Research Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Electronic address: c.vinnemeier@uke.de.
authors.forename: C D
authors.initials: CD
authors.lastname: Vinnemeier
authors.affiliation: Department for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: E M
authors.initials: EM
authors.lastname: Klupp
authors.affiliation: Infectious Diseases Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Krumkamp
authors.affiliation: I. Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany; Clinical Research Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Rolling
authors.affiliation: Department for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Fischer
authors.affiliation: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
authors.forename: E
authors.initials: E
authors.lastname: Owusu-Dabo
authors.affiliation: I. Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: M M
authors.initials: MM
authors.lastname: Addo
authors.affiliation: Faculty of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Y
authors.initials: Y
authors.lastname: Adu-Sarkodie
authors.affiliation: Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Käsmaier
authors.affiliation: Department for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Aepfelbacher
authors.affiliation: I. Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany; Takeda Pharmaceuticals, Vaccine Business Unit, Zurich, Switzerland.
authors.forename: J P
authors.initials: JP
authors.lastname: Cramer
authors.affiliation: Infectious Diseases Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: May
authors.affiliation: Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Tannich
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D005243:Feces / Q000382:microbiology; D005260:Female; D005869:Ghana / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D012424:Rural Population; D054851:Tropheryma / Q000302:isolation & purification*; D008061:Whipple Disease / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*
keywords: Africa; Tropheryma whipplei; children; diarrhoea; gastroenteritis; sub-Saharan; under-five-mortality