title: Serum level of interleukin-17A in patients with alopecia areata and its relationship to age.
abstract: BACKGROUND
  There is strong evidence for an autoimmune etiology of alopecia areata (AA). Interleukin-17A (IL-17A) is a Th17 proinflammatory cytokine that has been linked to the pathogeneses of diverse autoimmune and inflammatory diseases.
  
  
  OBJECTIVE
  This study aimed to measure serum IL-17A in AA patients and to study associations between IL-17A levels and AA severity, duration, and age of onset, and patient gender and age.
  
  
  METHODS
  The study enrolled 39 AA patients and 37 healthy control subjects. Scalp involvement was assessed using the Severity of Alopecia Tool (SALT), and clinical disease severity was determined. Serum IL-17A was measured using ELISAs.
  
  
  RESULTS
  Serum IL-17A was significantly higher in AA patients than in control subjects (P < 0.001). Correlations between serum IL-17A and gender, disease duration, SALT score, and disease severity were non-significant. Serum IL-17A was significantly higher in patients aged ≤30 years than in patients aged >30 years (P = 0.045). Age and serum IL-17A were significantly negatively correlated in patients with AA (rs = -0.363, P = 0.023) but not in control subjects (rs = -0.294, P = 0.077). Patients with juvenile-onset AA had significantly higher IL-17A levels than those with maturity-onset disease (P = 0.034). There was a significant negative correlation between age at disease onset and serum IL-17A (rs = -0.349, P = 0.029).
  
  
  CONCLUSIONS
  It is possible that IL-17A plays a role in the pathogenesis of AA. Serum IL-17A may be influenced by patient age and age of onset of AA but does not seem to influence disease severity.
authors.affiliation: Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
authors.forename: Eman H
authors.initials: EH
authors.lastname: El-Morsy
authors.affiliation: Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
authors.forename: Amira A
authors.initials: AA
authors.lastname: Eid
authors.affiliation: Department of Immunology, Medical Research Institute, Alexandria University, Alexandria, Egypt.
authors.forename: Hossam
authors.initials: H
authors.lastname: Ghoneim
authors.affiliation: Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
authors.forename: Khaleel A
authors.initials: KA
authors.lastname: Al-Tameemi
mesh_terms: D000328:Adult; D000367:Age Factors; D000506:Alopecia Areata / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015994:Incidence; D020381:Interleukin-17 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508717:IL17A protein, human; D020381:Interleukin-17