title: Translational Research and Functional Changes in Voiding Function in Older Adults.
abstract: Age-related LUT dysfunctions result from complex processes controlled by multiple genetic, epigenetic, and environmental factors and account for high costs of health care. This article discusses risk factors that may play a role in age-related LUT dysfunction and presents available data comparing structural and functional changes that occur with aging in the bladder of humans and animal models. A better understanding of factors and mechanisms underlying LUT symptoms in the older population may lead to therapeutic interventions to reduce these dysfunctions.
authors.affiliation: Renal-Electrolyte Division, Medicine Department, University of Pittsburgh School of Medicine, 3500 Terrace Street, A1220 Scaife Hall, Pittsburgh, PA 15261, USA.
authors.forename: Florenta Aura
authors.initials: FA
authors.lastname: Kullmann
authors.affiliation: Renal-Electrolyte Division, Medicine Department, University of Pittsburgh School of Medicine, 3500 Terrace Street, A1207 Scaife Hall, Pittsburgh, PA 15261, USA; Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
authors.forename: Lori Ann
authors.initials: LA
authors.lastname: Birder
authors.affiliation: Department of Urology, Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA; AIAS, Aarhus Institute of Advanced Studies, Aarhus University, Høegh-Guldbergs Gade 6B, Building 1632, Aarhus C 8000, Denmark. Electronic address: kea@aias.au.dk.
authors.forename: Karl-Erik
authors.initials: KE
authors.lastname: Andersson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D005260:Female; D006801:Humans; D009130:Muscle, Smooth / Q000503:physiopathology*; D011788:Quality of Life; D057170:Translational Research, Biomedical; D001743:Urinary Bladder / Q000503:physiopathology*
keywords: Animal models; Ischemia; LUTS; Overactive bladder; Underactive detrusor; Urinary bladder; Urinary incontinence; Voiding dysfunctions