title: An efficient solid-state synthesis of fluorescent surface carboxylated carbon dots derived from C60 as a label-free probe for iron ions in living cells.
abstract: In order to achieve the simple, easily repeated, and large scale preparation of fluorescent CDs, a new solid-state synthesis (SSS) approach was developed by calcining the mixture of fullerenes (C60) and solid sodium hydroxide. The cage of fullerenes could be opened and the hydroxyl and carboxyl were successfully introduced in the presence of sodium hydroxide under high temperature. The as-prepared surface carboxylated CDs possess many good properties, such as high water solubility, good photostability, salt tolerance, and nontoxicity. Especially, the fluorescence of CDs could be highly quenched by Fe(3+) because of the strong interaction of hydroxyl or carboxyl on the as-obtained CDs with Fe(3+), which realized a sensitive detection of Fe(3+) in the linear range of 0.02-0.6 μmol/L. What is more, we further applied the obtained CDs into the intracellular imaging of Fe(3+).
authors.affiliation: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lan
authors.affiliation: College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400716, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400716, China.
authors.forename: Mingxuan
authors.initials: M
authors.lastname: Gao
authors.affiliation: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China; College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400716, China. Electronic address: chengzhi@swu.edu.cn.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Huang
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D042541:Intracellular Space / Q000737:chemistry; D007501:Iron / Q000032:analysis* / Q000737:chemistry*; D057054:Molecular Imaging; D012972:Sodium Hydroxide / Q000737:chemistry; D013696:Temperature
chemical_list: D002264:Carboxylic Acids; D005456:Fluorescent Dyes; D037741:Fullerenes; D012972:Sodium Hydroxide; D007501:Iron; C069837:fullerene C60
keywords: Carboxylation; Fe(3+); Fluorescent carbon dots; Intracellular imaging; Solid-state synthesis (SSS)