title: Thymus Polypeptide Preparation Tactivin Restores Learning and Memory in Thymectomied Rats.
abstract: We studied the effects of tactivin and splenic polypeptides on learning and memory of thymectomized animals. In 3-week rats, thymectomy blocked active avoidance conditioning. Injections of tactivin (0.5 mg/kg) during 1 month after surgery restored learning capacity; splenic polypeptides were ineffective.
authors.affiliation: Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov, Moscow State University, Moscow, Russia. anna.novoseletskaya@gmail.com.
authors.forename: A V
authors.initials: AV
authors.lastname: Novoseletskaya
authors.affiliation: Department of Pharmacology,Pediatric Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.|Laboratory of Molecular Immunology and Biochemistry, Research Institute of Physicochemical Medicine, Federal Medical-and-Biological Agency of Russia, Moscow, Russia.
authors.forename: N M
authors.initials: NM
authors.lastname: Kiseleva
authors.affiliation: Laboratory of Molecular Immunology and Biochemistry, Research Institute of Physicochemical Medicine, Federal Medical-and-Biological Agency of Russia, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Zimina
authors.affiliation: Laboratory of Molecular Immunology and Biochemistry, Research Institute of Physicochemical Medicine, Federal Medical-and-Biological Agency of Russia, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Bystrova
authors.affiliation: Laboratory of Molecular Immunology and Biochemistry, Research Institute of Physicochemical Medicine, Federal Medical-and-Biological Agency of Russia, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Belova
authors.affiliation: Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov, Moscow State University, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Inozemtsev
authors.affiliation: Laboratory of Molecular Immunology and Biochemistry, Research Institute of Physicochemical Medicine, Federal Medical-and-Biological Agency of Russia, Moscow, Russia.
authors.forename: V Ya
authors.initials: VY
authors.lastname: Arion
authors.affiliation: Laboratory of Molecular Immunology and Biochemistry, Research Institute of Physicochemical Medicine, Federal Medical-and-Biological Agency of Russia, Moscow, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Sergienko
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D018697:Nootropic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D009928:Organ Specificity; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000737:chemistry; D013934:Thymectomy; D013949:Thymus Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D013950:Thymus Gland / Q000737:chemistry* / Q000502:physiology / Q000601:surgery
chemical_list: D018697:Nootropic Agents; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
keywords: learning; memory; thymectomy; thymus