title: The effect of bevacizumab for bone scintigraphy imaging: A case report.
abstract: A 65-year-old man presented with pulmonary nodules and a right humeral fracture. The 99mTc-hydroxy-methylene-diphosphonate (HMDP) bone scintigraphy showed high-intensity radioisotope (RI) uptake by a tumor of the right arm. Adenocarcinoma of the lung with an epidermal growth factor receptor (EGFR) mutation was diagnosed on pathological examination of the computed tomography (CT)-guided needle biopsy of the right humerus. Although, gefitinib therapy was initiated, the tumor progressed. The patient was then treated with second-line chemotherapy including bevacizumab. The CT scan showed a new bone metastasis in the ilium and right sacroiliac articulation. However, this new bone metastasis was not detected by HMDP-bone scintigraphy. Physicians should be wary of the interpretations of the findings of the 99mTc HMDP bone scintigraphy after the bevacizumab treatment.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Asano
authors.forename: Osamu
authors.initials: O
authors.lastname: Takakuwa
authors.forename: Ken
authors.initials: K
authors.lastname: Maeno
authors.affiliation: Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Oguri
authors.forename: Akio
authors.initials: A
authors.lastname: Niimi
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000368:Aged; D000068258:Bevacizumab / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D066246:ErbB Receptors / Q000235:genetics; D000077156:Gefitinib; D006801:Humans; D006811:Humerus / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008297:Male; D009154:Mutation; D011799:Quinazolines / Q000008:administration & dosage; D011859:Radiography; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate / Q000008:administration & dosage / Q000031:analogs & derivatives; D014055:Tomography, Emission-Computed
chemical_list: D011799:Quinazolines; D000068258:Bevacizumab; C024226:technetium Tc 99m hydroxymethylene diphosphonate; C512478:EGFR protein, human; D066246:ErbB Receptors; D000077156:Gefitinib; D013669:Technetium Tc 99m Medronate