title: Tigecycline Lock Therapy for Catheter-Related Bloodstream Infection Caused by KPC-Producing Klebsiella pneumoniae in Two Pediatric Hematological Patients.
abstract: Catheter-related bacteremias carry high mortality rates in hematological patients. When a multidrug-resistant microorganism is involved, the catheter should ideally be removed; however, this approach is not always possible. Tigecycline lock therapy was used in two pediatric oncohematological patients with intravascular catheter-related infection due to KPC-producing Klebsiella pneumoniae. The catheter was salvaged in both cases, and the patients were later discharged. Our experience suggests the usefulness of this approach in treating this type of infection.
authors.affiliation: Infectious Diseases Division, San Gerardo de' Tintori Hospital, Monza, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Foresti
authors.affiliation: Infectious Diseases Division, San Gerardo de' Tintori Hospital, Monza, Italy stefano932@gmail.com.
authors.forename: Stefano
authors.initials: S
authors.lastname: Di Bella
authors.affiliation: BMT Unit, Pediatric Department, San Gerardo de' Tintori Hospital, Monza, Italy.
authors.forename: Attilio
authors.initials: A
authors.lastname: Rovelli
authors.affiliation: BMT Unit, Pediatric Department, San Gerardo de' Tintori Hospital, Monza, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Sala
authors.affiliation: BMT Unit, Pediatric Department, San Gerardo de' Tintori Hospital, Monza, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Verna
authors.affiliation: Infectious Diseases Division, San Gerardo de' Tintori Hospital, Monza, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Bisi
authors.affiliation: Laboratory of Microbiology, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Nisii
authors.affiliation: Infectious Diseases Division, San Gerardo de' Tintori Hospital, Monza, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Gori
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D055499:Catheter-Related Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D062905:Central Venous Catheters; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007710:Klebsiella Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000078304:Tigecycline; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D000078304:Tigecycline; D008911:Minocycline