title: Targeting transcription factor STAT3 for cancer prevention and therapy.
abstract: Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.
authors.affiliation: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Edna Zhi Pei
authors.initials: EZ
authors.lastname: Chai
authors.affiliation: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Muthu K
authors.initials: MK
authors.lastname: Shanmugam
authors.affiliation: School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA 6009, Australia.
authors.forename: Frank
authors.initials: F
authors.lastname: Arfuso
authors.affiliation: School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA 6009, Australia.
authors.forename: Arunasalam
authors.initials: A
authors.lastname: Dharmarajan
authors.affiliation: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute of Singapore, Centre for Translational Medicine, 14 Medical Drive, #11-01M, Singapore 117599.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA 6009, Australia; Cancer Science Institute of Singapore, Centre for Translational Medicine, 14 Medical Drive, #11-01M, Singapore 117599; Department of Biological Sciences, University of North Texas, Denton, TX 76203, United States.
authors.forename: Alan Prem
authors.initials: AP
authors.lastname: Kumar
authors.affiliation: Department of Physiology, Centre for Life Sciences, NUHS, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456.
authors.forename: Ramar Perumal
authors.initials: RP
authors.lastname: Samy
authors.affiliation: Department of Physiology, Centre for Life Sciences, NUHS, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456.
authors.forename: Lina H K
authors.initials: LH
authors.lastname: Lim
authors.affiliation: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute of Singapore, Centre for Translational Medicine, 14 Medical Drive, #11-01M, Singapore 117599.
authors.forename: Lingzhi
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute of Singapore, Centre for Translational Medicine, 14 Medical Drive, #11-01M, Singapore 117599; Department of Haematology-Oncology, National University Health System, Singapore 117597.
authors.forename: Boon Cher
authors.initials: BC
authors.lastname: Goh
authors.affiliation: College of Korean Medicine, Kyung Hee University, Kyungheedae-gil, Dongdaemoon-gu, Seoul 130-701, Republic of Korea.
authors.forename: Kwang Seok
authors.initials: KS
authors.lastname: Ahn
authors.affiliation: Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore 169610.
authors.forename: Kam Man
authors.initials: KM
authors.lastname: Hui
authors.affiliation: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA 6009, Australia. Electronic address: phcgs@nus.edu.sg.
authors.forename: Gautam
authors.initials: G
authors.lastname: Sethi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D063646:Carcinogenesis / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control*; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D050796:STAT3 Transcription Factor
keywords: Angiogenesis; Apoptosis; Cancer; Cytokines; Proliferation; STAT3