title: A stimuli-responsive and bioactive film based on blended polyvinyl alcohol and cashew gum polysaccharide.
abstract: In this study, a stimuli-responsive, biodegradable and bioactive film was produced by blending cashew gum polysaccharide (CGP) and polyvinyl alcohol (PVA). The film presented malleability and mechanical properties enabling an easy handling. Wetting the film changed the optical property from opacity to levels of transparency higher than 70% and resulted in up to 2-fold increase in its superficial area. Different swelling indexes were obtained varying the pH of solvent, which allows classifying the CGP/PVA film as pH sensitive stimuli-responsive material. The bioactivity was achieved through covalent immobilization of papain, which remained active after storage of CGP/PVA-papain film for 24h in the presence of buffer or in a dry form. These results evidenced that CGP/PVA-papain film is a very promising material for biomedical applications.
authors.affiliation: Laboratório de Química de Polímeros, DBBM, ICB, Universidade Federal de Goiás, Brazil.
authors.forename: Fábio E F
authors.initials: FE
authors.lastname: Silva
authors.affiliation: Laboratório de Química de Polímeros, DBBM, ICB, Universidade Federal de Goiás, Brazil.
authors.forename: Karla A
authors.initials: KA
authors.lastname: Batista
authors.affiliation: Laboratório de Química de Polímeros, DBBM, ICB, Universidade Federal de Goiás, Brazil.
authors.forename: Maria C B
authors.initials: MC
authors.lastname: Di-Medeiros
authors.affiliation: Laboratório de Química de Polímeros, DBBM, ICB, Universidade Federal de Goiás, Brazil.
authors.forename: Cassio N S
authors.initials: CN
authors.lastname: Silva
authors.affiliation: Laboratório de Química de Polímeros, DBBM, ICB, Universidade Federal de Goiás, Brazil.
authors.forename: Bruna R
authors.initials: BR
authors.lastname: Moreira
authors.affiliation: Laboratório de Química de Polímeros, DBBM, ICB, Universidade Federal de Goiás, Brazil.. Electronic address: katia@icb.ufg.br.
authors.forename: Kátia F
authors.initials: KF
authors.lastname: Fernandes
mesh_terms: D031021:Anacardium / Q000378:metabolism; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010206:Papain / Q000737:chemistry / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D017155:Wettability
chemical_list: D004800:Enzymes, Immobilized; D011134:Polysaccharides; D011142:Polyvinyl Alcohol; D010206:Papain
keywords: Biocompatible film; Cashew gum polysaccharide; PEJU; Proteolytic enzyme; pH stimuli-responsive