title: Therapeutic effects of Ventolin versus hypertonic saline 3% for acute bronchiolitis in children.
abstract: BACKGROUND
  Complications of Ventolin as the most common drug used for bronchiolitis are widely known. The present study was conducted to determine the efficacy of hypertonic saline 3%, compared with Ventolin, for treatment of acute bronchiolitis in children.
  
  
  METHODS
  This double-blinded clinical trial study was conducted in Hajar Hospital, Shahrekord, Iran, from 2011 to 2012. A total of 70 patients under the age of two years with bronchiolitis were divided into two groups of 35 each. Ventolin nebulizer and hypertonic saline 3% nebulizer three times per day were administered in the first (Ventolin) and second (Hypersaline) group, respectively. The length of recovery was compared between the two groups. The data were analyzed by SPSS software (version 22) using chi-square, t-test, paired t-test, and Mann-Whitney.
  
  
  RESULTS
  The mean±SD length of recovery was 4.14±0.9 and 3.06±0.6 in the Ventolin and hypersaline groups, respectively. The mean duration of recovery was significantly lower in the hypersaline group (p<0.001).
  
  
  CONCLUSIONS
  Hypertonic saline 3% nebulizer has more pleasant therapeutic effects on acute bronchiolitis than Ventolin. Therefore, use of hypertonic saline 3% nebulizer is recommended for the treatment of acute bronchiolitis in children under two years old.
authors.affiliation: Assistant Professor, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran. zamani@yahoo.com.
authors.forename: Mohammad-Ali
authors.initials: MA
authors.lastname: Zamani
authors.affiliation: Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran. alirezannfor@yahoo.com.
authors.forename: Mehran
authors.initials: M
authors.lastname: Movahhedi
authors.affiliation: Assistant Professor, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran. dr.nourbakhsh2010@gmail.com.
authors.forename: Seyyed Mohammad-Kazem
authors.initials: SM
authors.lastname: Nourbakhsh
authors.affiliation: Assistant Professor, Department of Community Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. foruzan2000@yahoo.co.in.
authors.forename: Forouzan
authors.initials: F
authors.lastname: Ganji
authors.affiliation: Professor, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. rafieian@yahoo.com.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
authors.affiliation: Associate Professor, Department of Epidemiology, Shahrekord University of Medical Sciences, Shahrekord, Iran. mobasheri@skums.ac.ir.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mobasheri
authors.affiliation: Associate Professor, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran. nikakhosh@gmail.com.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Khoshdel
authors.affiliation: Assistant Professor, Department of Nursing, Shahrekord University of Medical Sciences, Shahrekord, Iran. shahram_410@yahoo.com.
authors.forename: Shahram
authors.initials: S
authors.lastname: Etemadifar
authors.affiliation: Assistant Professor, Department of Surgery, Shahrekord University of Medical Sciences, Shahrekord, Iran. shirani.m@skums.ac.ir.
authors.forename: Majid
authors.initials: M
authors.lastname: Shirani
authors.affiliation: MSc in Nursing, Shahrekord University of Medical Sciences, Shahrekord, Iran. keivaniz@yahoo.com.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Keivani Hafshejani
keywords: Bronchiolitis; Hypertonic saline solution; Pediatric; Ventolin-albuterol