title: Abnormal Baseline Brain Activity in Patients With Multiple Sclerosis With Simple Spinal Cord Involvement Detected by Resting-State Functional Magnetic Resonance Imaging.
abstract: OBJECTIVE
  The aim of this study was to assess the baseline brain activity in patients with multiple sclerosis with simple spinal cord involvement (MS-SSCI) using regional amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) as indexes.
  
  
  METHODS
  Resting-state functional magnetic resonance imaging data were acquired from 24 patients with MS-SSCI and 24 healthy controls and were processed using the Resting-State Functional Magnetic Resonance Imaging Data Analysis Toolkit. The relationships between expanded disability status scale scores, abnormal baseline brain activity, and disease duration were explored.
  
  
  RESULTS
  Compared with the controls, patients with MS-SSCI showed decreased ALFF in the right middle temporal gyrus, left middle frontal gyrus, lingual gyrus, and cuneus and increased ALFF in the right insula and bilateral supramarginal gyrus. Regions of abnormal fALFF were similar with those of ALFF. A significant correlation between expanded disability status scale scores and ALFF/fALFF was noted only in the right supramarginal gyrus.
  
  
  CONCLUSIONS
  Abnormal regional brain activity was detected in patients with MS-SSCI, which is probably due to spinal cord damage or potential brain damage.
authors.affiliation: From the Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Ben
authors.initials: B
authors.lastname: Meng
authors.forename: Chun
authors.initials: C
authors.lastname: Zeng
authors.forename: Jingjie
authors.initials: J
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Yin
authors.forename: Shambhu Kumar
authors.initials: SK
authors.lastname: Sah
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology*; D012146:Rest; D013116:Spinal Cord / Q000503:physiopathology*; D055815:Young Adult