title: Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase.
abstract: Hepatocyte chromosome polyploidization is an important feature of liver development and seems to be required for response to liver stress and injury signals. However, the question of how polyploidization can be tightly regulated in liver growth remains to be answered. Using a conditional knockout mouse model, liver-specific depletion of Ssu72 protein phosphatase was found to result in impairment in regulation of polyploidization. Interestingly, the aberrant polyploidization in Ssu72-depleted mice was associated with impaired liver damage response and increased markers of liver injury and seemed to mimic the phenotypic features of liver diseases such as fibrosis, steatosis, and steatohepatitis. In addition, depletion of Ssu72 caused deregulation of cell cycle progression by overriding the restriction point of the cell cycle and aberrantly promoting DNA endoreplication through G2 /M arrest.
  
  
  CONCLUSIONS
  Ssu72 plays a substantial role in the maintenance of hepatic chromosome homeostasis and would allow monitoring of liver function.
authors.affiliation: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.
authors.forename: Se-Hyuk
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.|Graduate School of Cancer Science and Policy, Research Institute, National Cancer Center, Goyang, Korea.
authors.forename: Yoon
authors.initials: Y
authors.lastname: Jeon
authors.affiliation: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Jin-Kwan
authors.initials: JK
authors.lastname: Lee
authors.affiliation: Graduate School of Cancer Science and Policy, Research Institute, National Cancer Center, Goyang, Korea.
authors.forename: Han Jeong
authors.initials: HJ
authors.lastname: Lim
authors.affiliation: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.
authors.forename: Donglim
authors.initials: D
authors.lastname: Kang
authors.affiliation: Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Hyeseong
authors.initials: H
authors.lastname: Cho
authors.affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Cheol-Keun
authors.initials: CK
authors.lastname: Park
authors.affiliation: Graduate School of Cancer Science and Policy, Research Institute, National Cancer Center, Goyang, Korea.
authors.forename: Ho
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.|Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Chang-Woo
authors.initials: CW
authors.lastname: Lee
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D002478:Cells, Cultured; D002875:Chromosomes / Q000235:genetics*; D022781:Hepatocytes / Q000502:physiology*; D006706:Homeostasis; D008099:Liver / Q000502:physiology*; D051379:Mice; D010749:Phosphoprotein Phosphatases; D011123:Polyploidy
chemical_list: D002352:Carrier Proteins; D010749:Phosphoprotein Phosphatases; C496300:SSU72 protein, human