title: Investigation of the role of IL17A gene variants in Chagas disease.
abstract: Human host genetic factors have been suggested to be determinants of the prevalence and clinical forms of Chagas disease. In this regard, IL-17A is believed to control parasitemia and protect against heart disease. In this work, we assessed whether IL17A gene polymorphisms are related to infection and/or development of the cardiac form of Chagas disease by genotyping for five IL17A SNPs (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) in 1171 individuals from a Colombian region endemic for Chagas disease, classified as seronegative (n=595), seropositive asymptomatic (n=175) and chronic Chagas cardiomyopathy (n=401). Our results showed that SNP rs8193036, which is located upstream of the coding region of the gene, was slightly associated with protection against T. cruzi infection (P=0.0170, P(FDR)=0.0851, odds ratio (OR)=0.80, confidence interval (CI)=0.66-0.96) and associated with protection against the development of cardiomyopathy (P=0.0065, P(FDR)=0.0324, OR=0.75, CI=0.60-0.92). This finding suggests that this IL17A polymorphism could be associated with Trypanosoma cruzi infection and the development of chronic cardiomyopathy due to differential expression of cytokine IL-17A.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, P.T.S., Granada, Spain.
authors.forename: D A
authors.initials: DA
authors.lastname: Leon Rodriguez
authors.affiliation: Clínica de Falla Cardíaca y Trasplante, Fundación Cardiovascular de Colombia, Floridablanca, Santander, Colombia.
authors.forename: L E
authors.initials: LE
authors.lastname: Echeverría
authors.affiliation: Grupo de Inmunología y Epidemiología Molecular, GIEM, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia.
authors.forename: C I
authors.initials: CI
authors.lastname: González
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, P.T.S., Granada, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Martin
mesh_terms: D002598:Chagas Cardiomyopathy / Q000235:genetics* / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D003105:Colombia; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics* / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17