title: [Immune response in cervical cancer. Strategies for the development of therapeutic vaccines].
abstract: High-risk human papillomaviruses (HR-HPV), as HPV-16, evade immune recognition through the inactivation of cells of the innate immune response. HPV-16 E6 and E7 genes down-regulate type I interferon response. They do not produce viremia or cell death; therefore, they do not cause inflammation or damage signal that alerts the immune system. Virus-like particles (VLPs), consisting of structural proteins (L1 and L2) of the main HR-HPV types that infect the genitourinary tract, are the most effective prophylactic vaccines against HR-HPV infection. While for the high grade neoplastic lesions, therapeutic vaccines based on viral vectors, peptides, DNA or complete HR-HPV E6 and E7 proteins as antigens, have had limited effectiveness. Chimeric virus-like particles (cVLPs) that carry immunogenic peptides derived from E6 and E7 viral proteins, capable to induce activation of specific cytotoxic T lymphocytes, emerge as an important alternative to provide prophylactic and therapeutic activity against HR-HPV infection and cervical cancer.
authors.affiliation: Laboratorio de Inmunobiología, Unidad de Investigación en Diferenciación Celular y Cáncer, Unidad Multidisciplinaria de Investigación Experimental Zaragoza (UMIEZ), Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Distrito Federal, México. mogl@servidor.unam.mx.
authors.forename: María Lourdes
authors.initials: ML
authors.lastname: Mora-García
authors.forename: Alberto
authors.initials: A
authors.lastname: Monroy-García
mesh_terms: D005260:Female; D006801:Humans; D007113:Immunity, Innate; D027383:Papillomaviridae / Q000276:immunology / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000150:complications / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D053918:Papillomavirus Vaccines / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000517:prevention & control / Q000821:virology*
chemical_list: D053918:Papillomavirus Vaccines
keywords: Cervical cancer; Human papillomavirus; Immune response antigens; Vaccines