title: Biomedical Applications of Self-Assembling Peptides.
abstract: Self-assembling peptides have gained increasing attention as versatile molecules to generate diverse supramolecular structures with tunable functionality. Because of the possibility to integrate a wide range of functional domains into self-assembling peptides including cell attachment sequences, signaling domains, vaccine epitopes, and even therapeutic moieties, complex nanostructures can be obtained with a wide range of applications in the biomedical field. The first part of this Review provides a concise overview of how peptide primary and secondary structure dictate the way such self-assembling peptides organize into higher ordered, supramolecular structures. Next, an overview of the literature will be given on recent studies on peptide self-assembly for application in drug delivery, vaccination, and tissue engineering.
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University , 3584 CG Utrecht, The Netherlands.
authors.forename: Mazda
authors.initials: M
authors.lastname: Rad-Malekshahi
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University , 3584 CG Utrecht, The Netherlands.
authors.forename: Ludwijn
authors.initials: L
authors.lastname: Lempsink
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University , 3584 CG Utrecht, The Netherlands.
authors.forename: Maryam
authors.initials: M
authors.lastname: Amidi
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University , 3584 CG Utrecht, The Netherlands.
authors.forename: Wim E
authors.initials: WE
authors.lastname: Hennink
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University , 3584 CG Utrecht, The Netherlands.
authors.forename: Enrico
authors.initials: E
authors.lastname: Mastrobattista
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D014611:Vaccination / Q000379:methods*
chemical_list: D010455:Peptides