title: [Prevalence of HPV-induced lesions in the anal canal among women with cervical intraepithelial neoplasia 2 and 3: cross-sectional study].
abstract: OBJECTIVE
  To determine the prevalence of HPV-induced lesions in the anal canal of women with cervical intraepithelial neoplasia (CIN) grade 2/3.
  
  
  METHODS
  A cross-sectional study was carried out from December 2008 to June 2009, in Pernambuco, northeastern Brazil. Only women with grade 2/3 CIN were included, and those who could not undergo anoscopy during their first visit were excluded. A cyttobrush was used for sample collection in order to identify HPV DNA through PCR and anal cytology. An anal biopsy was obtained in cases of abnormal anal cytology or major alterations in high resolution anoscopy (HRA).
  
  
  RESULTS
  Thirty-two percent (n=37/115) of HRA were normal and 63.5% (n=73/115) showed acetowhite epithelium. Twenty-two percent (n=26/115) of anal cytologies were abnormal. Among the latter, 12.2% (n=14/26) were low-grade anal intraepithelial lesions and 3.4% (n=4/26) were high-grade anal intraepithelial lesions. Twenty-two anal biopsies were performed, 13.7% of which (n=3/22) were grade 2 anal intraepithelial neoplasia (AIN2) and 9% (n=2/22) were grade 3 AIN. Th HPV DNA was identified in 72.1% of cases (n=83/115).
  
  
  CONCLUSIONS
  Women with CIN grade 2/3 showed a high prevalence of anal HPV infection and HPV-induced lesions.
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brasil.
authors.forename: Sandra de Andrade
authors.initials: Sde A
authors.lastname: Heráclio
authors.affiliation: Faculdade Pernambucana de Saúde, Recife, PE, Brasil.
authors.forename: Thaís Antunes
authors.initials: TA
authors.lastname: de Araujo
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brasil.
authors.forename: Alex Sandro Rolland
authors.initials: AS
authors.lastname: Souza
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brasil.
authors.forename: Kristiane
authors.initials: K
authors.lastname: Cahen
authors.affiliation: Universidade Federal Rural de Pernambuco, Recife, PE, Brasil.
authors.forename: Sergio Ferreira
authors.initials: SF
authors.lastname: Lima Junior
authors.affiliation: Centro de Apoio à Pesquisa, Universidade Federal Rural de Pernambuco, Recife, PE, Brasil.
authors.forename: Paulo Roberto Eleutério
authors.initials: PR
authors.lastname: de Souza
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brasil.
authors.forename: Melania Maria Ramos
authors.initials: MM
authors.lastname: Amorim
mesh_terms: D000293:Adolescent; D000328:Adult; D001003:Anal Canal; D001004:Anus Diseases / Q000150:complications* / Q000453:epidemiology* / Q000821:virology; D001938:Brazil; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology*; D015995:Prevalence; D002583:Uterine Cervical Neoplasms / Q000150:complications*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000150:complications*