title: Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents.
abstract: In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.
authors.affiliation: College of Science and Technology, Department of Chemistry, Florida A&M University, Tallahassee, FL 32307, USA.
authors.forename: Bereket
authors.initials: B
authors.lastname: Mochona
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Mazzio
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
authors.forename: Madhavei
authors.initials: M
authors.lastname: Gangapurum
authors.affiliation: College of Science and Technology, Department of Chemistry, Florida A&M University, Tallahassee, FL 32307, USA.
authors.forename: Nelly
authors.initials: N
authors.lastname: Mateeva
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Redda
keywords: 1, 3, 4-Oxadizole; Benzimidazole; Cytotoxcity; Pharmacophore hybridization