title: Biocompatible Supramolecular Catalytic One-Dimensional Nanofibers for Efficient Labeling of Live Cells.
abstract: Understanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal click reaction to label live cells. This biocompatible and biodegradable nanocatalyst was formed by self-assembled peptide nanofibers complexed with copper ions. The supramolecular nanocatalyst enhanced azide-alkyne cycloaddition reaction rate under physiological conditions and was shown to be useful for efficient bioorthogonal labeling of live cells.
authors.affiliation: Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University , Ankara, Turkey 06800.
authors.forename: Mohammad Aref
authors.initials: MA
authors.lastname: Khalily
authors.affiliation: Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University , Ankara, Turkey 06800.
authors.forename: Gulcihan
authors.initials: G
authors.lastname: Gulseren
authors.affiliation: Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University , Ankara, Turkey 06800.
authors.forename: Ayse B
authors.initials: AB
authors.lastname: Tekinay
authors.affiliation: Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University , Ankara, Turkey 06800.
authors.forename: Mustafa O
authors.initials: MO
authors.lastname: Guler
mesh_terms: D002384:Catalysis; D002470:Cell Survival; D057930:Click Chemistry; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D005434:Flow Cytometry / Q000379:methods; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D018613:Microscopy, Confocal / Q000379:methods; D008958:Models, Molecular; D057139:Nanofibers / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D013194:Staining and Labeling / Q000379:methods
chemical_list: D056831:Coordination Complexes; D005456:Fluorescent Dyes; D010455:Peptides; D003300:Copper