title: Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release.
abstract: Multifunctional folic acid conjugated BSA@Fe3O4 microcapsules (FA-BSA@Fe3O4 MCs) have been prepared successfully based on the sonochemical method. The as-synthesized FA-BSA@Fe3O4 MCs have a suitable size range for biomedical applications, and a high loading capacity for water-insoluble drugs. Furthermore, FA-BSA@Fe3O4 MCs show excellent magnetic properties. Cytotoxicity tests indicate that FA-BSA@Fe3O4 MCs are non-toxic. Cellular uptake and flow cytometric assay illustrate together that FA-BSA@Fe3O4 MCs can target tumor cells selectively through molecular targeted endocytosis. As carriers for water-insoluble drugs, FA-BSA@Fe3O4 MCs are also proved to possess superior redox- and thermo- dual responsiveness for controlled drug release.
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Zhanfeng
authors.initials: Z
authors.lastname: Li
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Fengzhi
authors.initials: F
authors.lastname: Xu
authors.affiliation: College of Life Sciences, Jilin University, Changchun 130012, China.
authors.forename: Quanshun
authors.initials: Q
authors.lastname: Li
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Songfeng
authors.initials: S
authors.lastname: Liu
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Interfaces, Max Planck Institute of Colloids and Interfaces, Potsdam 14476, Germany.
authors.forename: Helmuth
authors.initials: H
authors.lastname: Möhwald
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: cui_xj@jlu.edu.cn.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Cui
mesh_terms: D002214:Capsules; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D002214:Capsules; D012710:Serum Albumin, Bovine
keywords: Microcapsule; Multifunctional; Release; Sonochemical; Targeted