title: Facile synthesis of antibacterial chitosan/CuO bio-nanocomposite hydrogel beads.
abstract: CuO nanoparticles were synthesized in situ during the formation of physically cross-linked chitosan hydrogel beads using sodium tripolyphosphate as the cross-linker. The aim of the study was to investigate whether these nanocomposite beads have the potential to be used in drug delivery applications. The formation of CuO nanoparticles (CuONPs) in the hydrogels was confirmed by X-ray diffraction and scanning electron microscopy studies. SEM micrographs revealed the formation of CuONPs with size range of 10-25 nm within the hydrogel matrix. Furthermore, the antibacterial and swelling properties of the beads were studied. The prepared nanocomposite hydrogels showed a pH sensitive swelling behavior. The CuO nanocomposite hydrogels have rather higher swelling in different aqueous solutions in comparison with neat hydrogel. The nanocomposite hydrogels demonstrated good antibacterial effects against Escherichia coli and Staphylococcus aureus bacteria.
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran.
authors.forename: Sana
authors.initials: S
authors.lastname: Farhoudian
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran. Electronic address: yadollahi_mehdi@yahoo.com.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yadollahi
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran; Research Center for Pharmaceutical Nanonotechnology, Tabriz University of Medical Science, Tabriz, Iran. Electronic address: namazi@tabrizu.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Namazi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D003300:Copper; D048271:Chitosan; C030973:cupric oxide
keywords: Antibacterial; Bio-nanocomposite; Chitosan bead