title: Contextual bottom-up and implicit top-down modulation of anarchic hand syndrome: A single-case report and a review of the literature.
abstract: Anarchic hand syndrome (AHS) is a rare neurological condition characterized by seemingly purposeful, goal-directed hand movements which the person afflicted by the syndrome is not, however, in control of. By extensively examining a patient with AHS we provide novel neuropsychological and lesion mapping data that shed new light on the possibility of modulating specific symptoms associated with AHS, in particular unilateral apraxia and magnetic apraxia. Moreover, we compared lesion mapping data with an in depth analysis of previous studies in order to explore the neural network responsible for the complex symptomatology associated with this syndrome. We found that non-primarily motor variables (e.g. the nature of the object to be grasped and integration of visuo-spatial feedback in action) play an important role in determining AHS symptomatology. Moreover, we found that lesions involving various different parts of the motor control network (the corpus callosum, the anterior cingulate cortex and the supplementary motor area, the parietal areas and thalamus) are closely linked to partially differing AHS symptoms. The comparison of our data with those reported in previous studies indicate that AHS is a multifaceted and complex syndrome in which the influence of non-primarily motor, emotional and higher-order components may be largely underestimated.
authors.affiliation: NPSY.Lab- VR, Department of Philosophy, Education and Psychology, University of Verona, Italy. Electronic address: valentina.moro@univr.it.
authors.forename: Valentina
authors.initials: V
authors.lastname: Moro
authors.affiliation: NPSY.Lab- VR, Department of Philosophy, Education and Psychology, University of Verona, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Pernigo
authors.affiliation: NPSY.Lab- VR, Department of Philosophy, Education and Psychology, University of Verona, Italy; Department of Psychology, La Sapienza University of Rome and Fondazione Santa Lucia, IRCCS, Rome, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Scandola
authors.affiliation: Department of Rehabilitation, Sacro Cuore-Don Calabria Hospital, Negrar, Verona, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Mainente
authors.affiliation: Department of Rehabilitation, Sacro Cuore-Don Calabria Hospital, Negrar, Verona, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Avesani
authors.affiliation: Department of Psychology, La Sapienza University of Rome and Fondazione Santa Lucia, IRCCS, Rome, Italy.
authors.forename: Salvatore Maria
authors.initials: SM
authors.lastname: Aglioti
mesh_terms: D055964:Alien Limb Phenomenon / Q000209:etiology / Q000473:pathology* / Q000523:psychology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D005260:Female; D005868:Gestures; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000473:pathology / Q000523:psychology / Q000601:surgery; D008875:Middle Aged; D009434:Neural Pathways / Q000473:pathology; D009483:Neuropsychological Tests
keywords: Anarchic hand syndrome; Dangerous stimulus; Magnetic apraxia; Unilateral apraxia; Visual observation perspective