title: Paraoxanase as an indicator of myocardial ischemia and its utility in determining extension of ischemia.
abstract: BACKGROUND
  The aim of this study was to investigate Paraoxanase 1 (PON-1) activity in patients with ST-elevated and non-ST-elevated acute myocardial infarction (AMI) and to determine its correlation with Gensini scores (GSs).
  
  
  METHODS
  A total of 109 patients with AMI and 58 healthy subjects as control group were included in the study. Patients were divided into 2 subgroups as ST-elevated and non-ST-elevated AMI patients (Group I and II, respectively). Controls were named as Group III. PON-1 activity was determined on admission to emergency department for each group. In addition, GSs for patient groups were determined. Then, groups were compared according to their results.
  
  
  RESULTS
  PON-1 levels in Group I and II were significantly lower when compared to Group III. Median GSs for Group I and II were 60 and 64, respectively. The cut-off value of PON-1 for diagnosis of AMI was ≤180 U/L, which was identified by receiver characteristics receiver curve analysis. However, we could not determine a significant relationship between serum PON-1 levels and GSs in patients with AMI.
  
  
  CONCLUSIONS
  PON-1 levels measured on admission to emergency department may be used to rule out AMI. PON-1 levels in AMI patients are found to be inefficient in determining extension of ischemia measured by GS.
authors.affiliation: Department of Emergency Medicine, Hitit University, Çorum Education and Research Hospital, Çorum, Turkey. Electronic address: akerenler@hotmail.com.
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Erenler
authors.affiliation: Department of Biochemistry, Hitit University, Çorum Education and Research Hospital, Çorum, Turkey. Electronic address: ramazankocabas@gmail.com.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kocabaş
authors.affiliation: Department of Cardiology, Hitit University, Çorum Education and Research Hospital, Çorum, Turkey. Electronic address: tolga_dogan80@yahoo.com.
authors.forename: Tolga
authors.initials: T
authors.lastname: Doğan
authors.affiliation: Department of Biochemistry, Hitit University, Çorum Education and Research Hospital, Çorum, Turkey. Electronic address: hkemal@hotmail.com.
authors.forename: Hacı Kemal
authors.initials: HK
authors.lastname: Erdemli
authors.affiliation: Department of Cardiology, Hitit University, Çorum Education and Research Hospital, Çorum, Turkey. Electronic address: mucahityetim@hotmail.com.
authors.forename: Mücahit
authors.initials: M
authors.lastname: Yetim
mesh_terms: D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000201:enzymology; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D043303:Aryldialkylphosphatase