title: High titer L-lactic acid production from corn stover with minimum wastewater generation and techno-economic evaluation based on Aspen plus modeling.
abstract: Technological potentials of l-lactic acid production from corn stover feedstock were investigated by experimental and techno-economic studies. An optimal performance with 104.5 g/L in l-lactic acid titer and 71.5% in overall yield from cellulose in corn stover to l-lactic acid using an engineered Pediococcus acidilactici strain were obtained by overcoming several technical barriers. A rigorous Aspen plus model for l-lactic acid production starting from dry dilute acid pretreated and biodetoxified corn stover was developed. The techno-economic analysis shows that the minimum l-lactic acid selling price (MLSP) was $0.523 per kg, which was close to that of the commercial l-lactic acid produced from starch feedstock, and 24% less expensive than that of ethanol from corn stover, even though the xylose utilization was not considered. The study provided a prototype of industrial application and an evaluation model for high titer l-lactic acid production from lignocellulose feedstock.
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Jiaoe
authors.initials: J
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tu
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address: jbao@ecust.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Bao
mesh_terms: D007220:Industrial Waste / Q000032:analysis; D019344:Lactic Acid / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D008031:Lignin; D008962:Models, Theoretical; D062065:Wastewater / Q000032:analysis; D003313:Zea mays / Q000737:chemistry / Q000378:metabolism
chemical_list: D007220:Industrial Waste; D019344:Lactic Acid; D008031:Lignin; D062065:Wastewater; C036909:lignocellulose
keywords: Aspen plus modeling; Corn stover; Dry milling biorefinery process (DMBP); High titer l-lactic acid fermentation; Techno-economic analysis