title: The effects of abdominal lipectomy in metabolic syndrome components and insulin sensitivity in females: A systematic review and meta-analysis.
abstract: BACKGROUND
  Adipose tissue is an endocrine organ, which is implicated in the pathogenesis of obesity, metabolic syndrome and diabetes. Lipectomy offers a unique opportunity to permanently reduce the absolute number of fat cells, though its functional role remains unclear. This systematic and meta-analysis review aims to assess the effect of abdominal lipectomy on metabolic syndrome components and insulin sensitivity in women.
  
  
  METHODS
  A predetermined protocol, established according to the Cochrane Handbook's recommendations, was used. An electronic search in MEDLINE, Scopus, the Cochrane Library and CENTRAL electronic databases was conducted from inception to May 14, 2015. This search was supplemented by a review of reference lists of potentially eligible studies and a manual search of key journals in the field of plastic surgery. Eligible studies were prospective studies with ≥1month of follow-up that included females only who underwent abdominal lipectomy and reported on parameters of metabolic syndrome and insulin sensitivity.
  
  
  RESULTS
  The systematic review included 11 studies with a total of 271 individuals. Conflicting results were revealed, though most studies showed no significant metabolic effects after lipectomy. The meta-analysis included 4 studies with 140 subjects. No significant changes were revealed between lipectomy and control groups.
  
  
  CONCLUSIONS
  This meta-analysis provides evidence that abdominal lipectomy in females does not affect significantly the components of metabolic syndrome and insulin sensitivity. Further high quality studies are needed to elucidate the potential metabolic effects of abdominal lipectomy. Systematic review registration PROSPERO CRD42015017564 (www.crd.york.ac.uk/PROSPERO).
authors.affiliation: Plastic Surgeon, private practice, Zurich, Switzerland; Department of Plastic Surgery, Medical School, Aristotle University of Thessaloniki, Greece. Electronic address: drseretis@gmail.com.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Seretis
authors.affiliation: Unit of Reproductive Endocrinology, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Goulis
authors.affiliation: Laboratory of Biochemistry, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Koliakos
authors.affiliation: Department of Plastic Surgery, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: Efterpi
authors.initials: E
authors.lastname: Demiri
mesh_terms: D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000601:surgery*; D015187:Lipectomy; D024821:Metabolic Syndrome / Q000378:metabolism*
keywords: Abdominoplasty; Cholesterol; Insulin; Lipectomy; Metabolic