title: Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework.
abstract: A dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin-resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug-release testing, in this study, a set of transwell assay-based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn-MOF towards A2780cis.
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China). rwysun@stu.edu.cn.
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China). dli@stu.edu.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
authors.forename: Zhi-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
authors.forename: Hong
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
authors.forename: Mian
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
authors.forename: Yue-Jiao
authors.initials: YJ
authors.lastname: Xian
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur (Malaysia).|Chemistry Department, King Abdulaziz University, 80203 Jeddah (Saudi Arabia).
authors.forename: Seik Weng
authors.initials: SW
authors.lastname: Ng
authors.affiliation: School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong (P. R. China).
authors.forename: Alice Sze-Tsai
authors.initials: AS
authors.lastname: Wong
mesh_terms: D002460:Cell Line; D002945:Cisplatin / Q000737:chemistry*; D005260:Female; D006046:Gold / Q000737:chemistry*; D017612:Gold Compounds / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000188:drug therapy* / Q000473:pathology*; D013859:Thiocarbamates / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D017612:Gold Compounds; D008024:Ligands; D013859:Thiocarbamates; D006046:Gold; D015032:Zinc; D002945:Cisplatin
keywords: cancer; carbenes; dithiocarbamate; gold; metal-organic frameworks