title: Do genome-scale models need exact solvers or clearer standards?
authors.affiliation: Department of Bioengineering, University of California, San Diego, CA, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Ebrahim
authors.affiliation: Department of Biotechnology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
authors.forename: Eivind
authors.initials: E
authors.lastname: Almaas
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belval, Luxembourg.
authors.forename: Eugen
authors.initials: E
authors.lastname: Bauer
authors.affiliation: Sinopia Biosciences Inc., San Diego, CA, USA.
authors.forename: Aarash
authors.initials: A
authors.lastname: Bordbar
authors.affiliation: Genomatica, Inc., San Diego, CA, USA.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Burgard
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Chang
authors.affiliation: Department of Bioengineering, University of California, San Diego, CA, USA Center for Bioinformatics Tuebingen (ZBIT), University of Tuebingen, Tübingen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Dräger
authors.affiliation: Intrexon, Inc., San Diego, CA, USA.
authors.forename: Iman
authors.initials: I
authors.lastname: Famili
authors.affiliation: Department of Bioengineering, University of California, San Diego, CA, USA.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Feist
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belval, Luxembourg.
authors.forename: Ronan Mt
authors.initials: RM
authors.lastname: Fleming
authors.affiliation: Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Fong
authors.affiliation: Laboratory of Computational Systems Biotechnology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Vassily
authors.initials: V
authors.lastname: Hatzimanikatis
authors.affiliation: The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Herrgård
authors.affiliation: Department of Mathematics, Rose-Hulman Institute of Technology, Terre Haute, IN, USA.
authors.forename: Allen
authors.initials: A
authors.lastname: Holder
authors.affiliation: Department of Computing and Mathematical Science, California Institute of Technology, Pasadena, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Hucka
authors.affiliation: Department of Biological Engineering, Utah State University, Logan, UT, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hyduke
authors.affiliation: Department of Radiology, University of California, Los Angeles, CA, USA Institute of Engineering in Medicine, University of California, San Diego, CA, USA.
authors.forename: Neema
authors.initials: N
authors.lastname: Jamshidi
authors.affiliation: The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
authors.forename: Sang Yup
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Babraham Institute, Cambridge, UK.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Le Novère
authors.affiliation: Department of Bioengineering, University of California, San Diego, CA, USA.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Lerman
authors.affiliation: Department of Pediatrics, University of California, San Diego, CA, USA.
authors.forename: Nathan E
authors.initials: NE
authors.lastname: Lewis
authors.affiliation: Department of Management Science and Engineering, Stanford University, Stanford, CA, USA.
authors.forename: Ding
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Mahadevan
authors.affiliation: Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
authors.forename: Costas
authors.initials: C
authors.lastname: Maranas
authors.affiliation: Genomatica, Inc., San Diego, CA, USA.
authors.forename: Harish
authors.initials: H
authors.lastname: Nagarajan
authors.affiliation: Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, CA, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Navid
authors.affiliation: The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
authors.forename: Jens
authors.initials: J
authors.lastname: Nielsen
authors.affiliation: Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Lars K
authors.initials: LK
authors.lastname: Nielsen
authors.affiliation: Department of Environmental Biology, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Nogales
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belval, Luxembourg.
authors.forename: Alberto
authors.initials: A
authors.lastname: Noronha
authors.affiliation: Synthetic and Systems Biology Unit, Biological Research Center, Szeged, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Pal
authors.affiliation: Department of Bioengineering, University of California, San Diego, CA, USA.
authors.forename: Bernhard O
authors.initials: BO
authors.lastname: Palsson
authors.affiliation: Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Papin
authors.affiliation: European Molecular Biology Laboratory, Heidelberg, Germany.
authors.forename: Kiran R
authors.initials: KR
authors.lastname: Patil
authors.affiliation: Institute for Systems Biology, Seattle, WA, USA.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Price
authors.affiliation: Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Reed
authors.affiliation: Department of Management Science and Engineering, Stanford University, Stanford, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Saunders
authors.affiliation: Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA, USA.
authors.forename: Ryan S
authors.initials: RS
authors.lastname: Senger
authors.affiliation: The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Sonnenschein
authors.affiliation: Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA.
authors.forename: Yuekai
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belval, Luxembourg.
authors.forename: Ines
authors.initials: I
authors.lastname: Thiele
mesh_terms: D016678:Genome; D008954:Models, Biological; D013816:Thermodynamics