title: Current Options for the Treatment of Food Allergy.
abstract: Food allergy is increasing in prevalence; as a result, there is intense focus on developing safe and effective therapies. Current methods of specific immunotherapy include oral, sublingual, and epicutaneous, while nonspecific methods that have been investigated include: Chinese herbal medicine, probiotics, and anti-IgE antibodies. Although some studies have demonstrated efficacy in inducing desensitization, questions regarding safety and the potential for achieving immune tolerance remain. Although some of these therapies demonstrate promise, further investigation is required before their incorporation into routine clinical practice.
authors.affiliation: Department of Pediatric, University of Colorado Denver School of Medicine, Aurora, CO, USA; National Jewish Health, 1400 Jackson Street, J322, Denver, CO 80206, USA. Electronic address: lanserb@njhealth.org.
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Lanser
authors.affiliation: Department of Pediatric, University of North Carolina at Chapel Hill School of Medicine, Campus Box #7231, Chapel Hill, NC 27599, USA; Allergy, Asthma & Clinical Immunology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Wright
authors.affiliation: Department of Pediatric, University of North Carolina at Chapel Hill School of Medicine, Campus Box #7231, Chapel Hill, NC 27599, USA.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Orgel
authors.affiliation: Department of Pediatric, University of North Carolina at Chapel Hill School of Medicine, Campus Box #7231, Chapel Hill, NC 27599, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Vickery
authors.affiliation: Department of Pediatric, University of Colorado Denver School of Medicine, Aurora, CO, USA; Children's Hospital Colorado, 13123 E. 16th Ave, B518, Aurora, CO 80045, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Fleischer
mesh_terms: D000707:Anaphylaxis / Q000517:prevention & control; D018926:Anti-Allergic Agents / Q000627:therapeutic use; D002648:Child; D003888:Desensitization, Immunologic; D005512:Food Hypersensitivity / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D000069444:Omalizumab / Q000627:therapeutic use; D010353:Patient Education as Topic; D019936:Probiotics / Q000627:therapeutic use
chemical_list: D018926:Anti-Allergic Agents; D000069444:Omalizumab
keywords: Anaphylaxis; Desensitization; Food allergy treatment; Food allergy/hypersensitivity; Immunotherapy; Omalizumab; Probiotics; Tolerance