title: Editor's Choice-- A Systematic Review of Endovenous Stenting in Chronic Venous Disease Secondary to Iliac Vein Obstruction.
abstract: OBJECTIVE
  Deep endovenous stenting to relieve chronic venous disease (CVD) secondary to post-thrombotic or non-thrombotic iliac vein obstruction is becoming increasingly well described. However, current and adequately reported systematic reviews on the topic are lacking. This report aimed to produce a systematic review and meta-analysis of the available data, reported to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline.
  
  
  METHODS
  MEDLINE, EMBASE, and the Cochrane Central Register for Controlled Trials databases and key references were searched.
  
  
  RESULTS
  Sixteen studies were included (14 before-and-after studies, 1 controlled before-and-after study, and 1 case series) encompassing successful deep venous stenting in 2,373 and 2,586 post-thrombotic or non-thrombotic limbs and patients respectively. The data were too heterogeneous to perform a meta-analysis. There were significant improvements in validated measures of the severity of CVD and venous disease-specific quality of life. Persistent ulcer healing rates ranged from 56% to 100% in limbs that had often already failed conservative management. Primary and secondary stent patency ranged from 32% to 98.7% and 66%-96% respectively. The major complication rate ranged from 0 to 8.7% per stented limb. A GRADE assessment demonstrated the quality of the evidence for five outcomes to be "Very Low" and one to be "Low" (ulcer healing).
  
  
  CONCLUSIONS
  The quality of evidence to support the use of deep venous stenting to treat obstructive CVD is currently weak. The treatment does however appear promising and is safe and should therefore be considered as a treatment option while the evidence base is improved.
authors.affiliation: Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Seager
authors.affiliation: Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Busuttil
authors.affiliation: Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, UK.
authors.forename: B
authors.initials: B
authors.lastname: Dharmarajah
authors.affiliation: Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, UK. Electronic address: a.h.davies@imperial.ac.uk.
authors.forename: A H
authors.initials: AH
authors.lastname: Davies
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D003251:Constriction, Pathologic; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation*; D004867:Equipment Design; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007084:Iliac Vein / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome; D014654:Vascular Patency; D014689:Venous Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D055815:Young Adult
keywords: Angioplasty; Iliac vein compression syndrome; Post-thrombotic syndrome; Stents; Systematic review; Venous insufficiency