title: Plasma miR-185 as a predictive biomarker for prognosis of malignant glioma.
abstract: BACKGROUND
  Specific microRNA (miRNA) expression signatures have been identified in a variety of human cancers. More recently, increasing evidence shows that miRNAs exist in human blood serum and plasma.
  
  
  METHODS
  Levels of miR-185 in plasma were measured by quantitative reverse-transcriptase polymerase chain reaction in 66 glioma patients, 11 pituitary adenoma patients, 32 meningioma patients, and 14 acoustic neuroma patients.
  
  
  RESULTS
  The plasma levels of miR-185 were significantly altered in glioma patients compared to normal controls. However, its levels were not observably changed in patients with other brain tumors such as meningioma, acoustic neuroma, or pituitary adenoma. Furthermore, the plasma levels of miR-185 in glioblastoma multiforme patients with operation and chemo-radiation almost revived to normal levels. Finally, we also demonstrated that low plasma miR-185 levels are correlated with poor survival in glioma patients.
  
  
  CONCLUSIONS
  These findings suggest that plasma miR-185 has become potential biomarkers for glioma and may be useful in clinical management for glioma patients.
authors.forename: Hailin
authors.initials: H
authors.lastname: Tang
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Xinhua
authors.initials: X
authors.lastname: Xie
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Xie
authors.affiliation: The Center for Skull Base Surgery and Neurooncology, Hunan Province, China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000097:blood* / Q000473:pathology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C552431:MIRN185 microRNA, human; D035683:MicroRNAs