title: A highly-efficient imprinted magnetic nanoparticle for selective separation and detection of 17β-estradiol in milk.
abstract: In this work, we prepared molecularly imprinted polymers (MIPs) combining surface molecular imprinting technique and magnetic separation for separation and determination of 17β-estradiol (E2) from milk. During the synthesis process, the acryloyl chloride was specially used to graft double bonds on Fe3O4 nanoparticles and served as co-functional monomer cooperating with acrylamide. The morphology, structure property, and the best polymerization and adsorption conditions of the prepared magnetic nanoparticles were investigated in detail. The obtained nanomaterials displayed high adsorption capacity of 12.62mg/g, fast equilibrium time of 10min, and satisfactory selectivity for target molecule. What's more, the MIPs was successfully applied as sorbents to specifically separate and enrich E2 from milk with a relatively high recovery (88.9-92.1%), demonstrating the potential application of the MIPs as solid phase extractant for rapid, highly-efficient, and cost-effective sample analysis.
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: ruixiagao@mail.xjtu.edu.cn.
authors.forename: Ruixia
authors.initials: R
authors.lastname: Gao
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an 710049, China; College of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Xihui
authors.initials: X
authors.lastname: Cui
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an 710049, China; College of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an 710049, China; College of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary Surgery, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Dechun
authors.initials: D
authors.lastname: Liu
authors.affiliation: Institute of Analytical Science, School of Science, Xi'an Jiaotong University, Xi'an 710049, China; College of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: tyh57@mail.xjtu.edu.cn.
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Tang
mesh_terms: D000818:Animals; D002417:Cattle; D004958:Estradiol / Q000032:analysis / Q000737:chemistry*; D059022:Food Safety; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008892:Milk / Q000737:chemistry*; D054802:Molecular Imprinting / Q000379:methods*
chemical_list: D058185:Magnetite Nanoparticles; D004958:Estradiol
keywords: 17β-Estradiol; 2,2-Azobisisobutyronitrile (PubChem CID: 6547); Acetonitrile (PubChem CID: 6342); Acrylamide (PubChem CID: 6579); Acryloyl chloride (PubChem CID: 13140); Diethylstilbestrol (PubChem CID: 448537); Estradiol (PubChem CID: 5757); Estriol (PubChem CID: 5756); Estrone (PubChem CID: 5870); Ethanol (PubChem CID: 702); Ferric chloride (PubChem CID: 24380); Food safety; Magnetic separation; Molecular imprinting nanoparticles