title: A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult.
abstract: Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained.
authors.affiliation: Department of Pathology, Kasturba Medical College, Mangalore, Manipal University, Manipal, India.
authors.forename: H B
authors.initials: HB
authors.lastname: Sridevi
authors.forename: P R
authors.initials: PR
authors.lastname: Shanthala
authors.forename: C V
authors.initials: CV
authors.lastname: Raghuveer
authors.forename: Ananth K
authors.initials: AK
authors.lastname: Prabhu
authors.forename: Jallaluddin K C
authors.initials: JK
authors.lastname: Akbar
authors.forename: G S
authors.initials: GS
authors.lastname: Shivaprasad
authors.forename: Pooja K
authors.initials: PK
authors.lastname: Suresh
authors.forename: Sanjay
authors.initials: S
authors.lastname: Navani
mesh_terms: D000293:Adolescent; D000077548:Anaplastic Lymphoma Kinase; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases