title: Vitamin B₁₂ deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a.
abstract: Vitamin B12 deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a vitamin B12 deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B12 deficiency suggests that vitamin B12 plays an important role in Pi homeostasis.
authors.affiliation: a Faculty of Applied Bioscience, Department of Applied Biology and Chemistry , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shiga
authors.affiliation: b Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition , Josai University , Saitama , Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kimira
authors.affiliation: b Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition , Josai University , Saitama , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mano
authors.affiliation: c Division of Life, Health, and Sports Education , Graduate School of Education, Okayama University , Okayama , Japan.
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Kawata
authors.affiliation: c Division of Life, Health, and Sports Education , Graduate School of Education, Okayama University , Okayama , Japan.
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Tadokoro
authors.affiliation: a Faculty of Applied Bioscience, Department of Applied Biology and Chemistry , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: a Faculty of Applied Bioscience, Department of Applied Biology and Chemistry , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001862:Bone Resorption; D006706:Homeostasis; D007668:Kidney / Q000378:metabolism*; D010010:Osteoclasts / Q000473:pathology*; D010710:Phosphates / Q000378:metabolism*; D051381:Rats; D050613:Sodium-Phosphate Cotransporter Proteins, Type IIa / Q000502:physiology*; D014806:Vitamin B 12 Deficiency / Q000503:physiopathology*
chemical_list: D010710:Phosphates; D050613:Sodium-Phosphate Cotransporter Proteins, Type IIa
keywords: Napi2a; bone disorder; inorganic phosphorus