title: Patient-centric trials for therapeutic development in precision oncology.
abstract: An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours. Considerable associated challenges include how to advance and implement targeted drug-development strategies. Precision medicine centres on delivering the most appropriate therapy to a patient on the basis of clinical and molecular features of their disease. The development of therapeutic agents that target molecular mechanisms is driving innovation in clinical-trial strategies. Although progress has been made, modifications to existing core paradigms in oncology drug development will be required to realize fully the promise of precision medicine.
authors.affiliation: Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland G61 1BD, UK.|The Kinghorn Cancer Centre, Cancer Division, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.|Department of Surgery, Bankstown Hospital, Sydney, New South Wales 2200, Australia.|South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, New South Wales 2170, Australia.
authors.forename: Andrew V
authors.initials: AV
authors.lastname: Biankin
authors.affiliation: Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90095, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Piantadosi
authors.affiliation: Innovative Medicines &Early Development Oncology, AstraZeneca, Cambridge Science Park, Cambridge CB4 0FZ, UK.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Hollingsworth
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods* / Q000639:trends; D055808:Drug Discovery / Q000379:methods*; D005820:Genetic Testing; D006801:Humans; D008495:Medical Oncology / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*; D018579:Patient Selection; D057285:Precision Medicine / Q000379:methods*