title: Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria.
abstract: Two bioactive cyclic dipeptides, cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr), were isolated from the culture broth of Streptomyces sp. strain 22-4 and tested against three economically important plant pathogens, Xanthomonas axonopodis pv. citri, Ralstonia solanacearum and Clavibacter michiganensis. Both cyclic dipeptides were active against X. axonopodis pv. citri and R. Solanacearum with MIC of 31.25 μg/mL. No activity could be observed against C. michiganensis.
authors.affiliation: a Faculty of Science, Department of Chemistry, Center of Excellence for Innovation in Chemistry and Special Research Unit for Advanced Magnetic Resonance , Kasetsart University , Bangkok , Thailand.
authors.forename: Pakorn
authors.initials: P
authors.lastname: Wattana-Amorn
authors.affiliation: a Faculty of Science, Department of Chemistry, Center of Excellence for Innovation in Chemistry and Special Research Unit for Advanced Magnetic Resonance , Kasetsart University , Bangkok , Thailand.
authors.forename: Waranya
authors.initials: W
authors.lastname: Charoenwongsa
authors.affiliation: b School of Chemistry , University of Bristol , Bristol , United Kingdom.
authors.forename: Christopher
authors.initials: C
authors.lastname: Williams
authors.affiliation: b School of Chemistry , University of Bristol , Bristol , United Kingdom.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Crump
authors.affiliation: c Faculty of Engineering and Industrial Technology, Department of Biotechnology , Silpakorn University , Nakhon Pathom , Thailand.
authors.forename: Busaya
authors.initials: B
authors.lastname: Apichaisataienchote
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004151:Dipeptides / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology*; D010879:Piperazines / Q000302:isolation & purification / Q000494:pharmacology; D010935:Plant Diseases / Q000382:microbiology*; D043367:Ralstonia / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*; D014974:Xanthomonas / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004151:Dipeptides; D010456:Peptides, Cyclic; D010879:Piperazines; C120594:tyrosyl-proline; C085319:maculosin
keywords: Cyclo(L-Pro-L-Tyr); Streptomyces; cyclo(D-Pro-L-Tyr); phytopathogenic bacteria