title: Effect of the use of combination uridine triphosphate, cytidine monophosphate, and hydroxycobalamin on the recovery of neurosensory disturbance after bilateral sagittal split osteotomy: a randomized, double-blind trial.
abstract: The change in neurosensory lesions that develop after bilateral sagittal split osteotomy (BSSO) was explored, and the influence of the application of combination uridine triphosphate (UTP), cytidine monophosphate (CMP), and hydroxycobalamin (vitamin B12) on patient outcomes was assessed. This was a randomized, controlled, double-blind trial. The study sample comprised 12 patients, each evaluated on both sides (thus 24 sides). All patients fulfilled defined selection criteria. Changes in the lesions were measured both subjectively and objectively. The sample was divided into two patient groups: an experimental group receiving medication and a control group receiving placebo. The statistical analysis was performed using SPSS software. Lesions in both groups improved and no statistically significant difference between the groups was observed at any time. 'Severe' injuries in the experimental group were more likely to exhibit a significant improvement after 6 months. Based on the results of the present study, it is concluded that the combination UTP, CMP, and hydroxycobalamin did not influence recovery from neurosensory disorders.
authors.affiliation: Dentistry School, University of Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: C L
authors.initials: CL
authors.lastname: Vieira
authors.affiliation: Department of Maxillofacial Surgery and Traumatology, University of Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: B C do E
authors.initials: BC
authors.lastname: Vasconcelos
authors.affiliation: Oral Medicine Unit, Department of Clinics and Preventive Dentistry, University of Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: J C
authors.initials: JC
authors.lastname: Leão
authors.affiliation: Department of Maxillofacial Surgery and Traumatology, University of Pernambuco, Recife, Pernambuco, Brazil. Electronic address: laureano.filho@upe.br.
authors.forename: J R
authors.initials: JR
authors.lastname: Laureano Filho
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D003430:Cross-Sectional Studies; D003568:Cytidine Monophosphate / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use*; D008297:Male; D019767:Maxillofacial Abnormalities / Q000601:surgery*; D059229:Osteotomy, Sagittal Split Ramus; D011446:Prospective Studies; D012678:Sensation Disorders / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome; D014544:Uridine Triphosphate / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D014803:Vitamin B Complex; D003568:Cytidine Monophosphate; D006879:Hydroxocobalamin; D014544:Uridine Triphosphate
keywords: mandibularnerve; nervous system trauma; orthognathic surgery; therapeutics