title: Formyl peptide receptors at the interface of inflammation, angiogenesis and tumor growth.
abstract: N-formyl peptide receptors (FPRs) belong to the family of pattern recognition receptors (PRRs) that regulate innate immune responses. Three FPRs have been identified in humans: FPR1-FPR3. FPR expression was initially described in immune cells and subsequently in non-hematopoietic cells and certain tissues. Besides their involvement in inflammatory disorders, FPRs have been implicated in the regulation of tissue repair and angiogenesis. Angiogenesis is not only a key component of pathogen defence during acute infection and of chronic inflammatory disorders, but also plays a critical role in wound healing and tissue regeneration. Moreover, pathologic uncontrolled angiogenesis is central for tumour growth, progression, and the formation of metastases. In this review, we summarise the evidence for a central role of FPRs at the intersection between inflammation, physiologic angiogenesis and pathologic neovascularisation linked to cancer. These findings provide insights into the potential clinical relevance of new treatment regimens involving FPR modulation.
authors.affiliation: Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131 Naples, Italy.
authors.forename: Nella
authors.initials: N
authors.lastname: Prevete
authors.affiliation: Department of Molecular Medicine and Medical Biotechnology (DMMBM), University of Naples Federico II, 80131 Naples, Italy; Institute of Endocrinology and Experimental Oncology (IEOS) "G. Salvatore", CNR, 80131 Naples, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Liotti
authors.affiliation: Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131 Naples, Italy; Institute of Endocrinology and Experimental Oncology (IEOS) "G. Salvatore", CNR, 80131 Naples, Italy; Center for Basic and Clinical Immunologic Research (CISI), University of Naples Federico II, 80131 Naples, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Marone
authors.affiliation: Department of Molecular Medicine and Medical Biotechnology (DMMBM), University of Naples Federico II, 80131 Naples, Italy; Institute of Endocrinology and Experimental Oncology (IEOS) "G. Salvatore", CNR, 80131 Naples, Italy. Electronic address: rosmelil@unina.it.
authors.forename: Rosa Marina
authors.initials: RM
authors.lastname: Melillo
authors.affiliation: Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, 80131 Naples, Italy; Center for Basic and Clinical Immunologic Research (CISI), University of Naples Federico II, 80131 Naples, Italy. Electronic address: depaulis@unina.it.
authors.forename: Amato
authors.initials: A
authors.lastname: de Paulis
mesh_terms: D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D044042:Receptors, Formyl Peptide / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology
chemical_list: D044042:Receptors, Formyl Peptide