title: Radiation dose reduction in perfusion CT imaging of the brain: A review of the literature.
abstract: Perfusion CT (PCT) of the brain is widely used in the settings of acute ischemic stroke and vasospasm monitoring. The high radiation dose associated with PCT is a central topic and has been a focus of interest for many researchers. Many studies have examined the effect of radiation dose reduction in PCT using different approaches. Reduction of tube current and tube voltage can be efficient and lead to a remarkable reduction of effective radiation dose while preserving acceptable image quality. The use of novel noise reduction techniques such as iterative reconstruction or spatiotemporal smoothing can produce sufficient image quality from low-dose perfusion protocols. Reduction of sampling frequency of perfusion images has only little potential to reduce radiation dose. In the present article we aimed to summarize the available data on radiation dose reduction in PCT imaging of the brain.
authors.affiliation: Department of diagnostic and interventional neuroradiology, RWTH Aachen university, 52074 Aachen, Germany; Department for diagnostic and interventional radiology, Eberhard Karls University Tuebingen, university hospital Tuebingen, Hoppe-Seyler-Straße 3, 72076 Tübingen, Germany. Electronic address: ahmed.e.othman@googlemail.com.
authors.forename: Ahmed E
authors.initials: AE
authors.lastname: Othman
authors.affiliation: Department of diagnostic and interventional neuroradiology, RWTH Aachen university, 52074 Aachen, Germany.
authors.forename: Saif
authors.initials: S
authors.lastname: Afat
authors.affiliation: Department of diagnostic and interventional neuroradiology, RWTH Aachen university, 52074 Aachen, Germany.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Brockmann
authors.affiliation: Department of diagnostic and interventional neuroradiology, RWTH Aachen university, 52074 Aachen, Germany.
authors.forename: Omid
authors.initials: O
authors.lastname: Nikoubashman
authors.affiliation: Department of diagnostic and interventional neuroradiology, RWTH Aachen university, 52074 Aachen, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Brockmann
authors.affiliation: Department for diagnostic and interventional radiology, Eberhard Karls University Tuebingen, university hospital Tuebingen, Hoppe-Seyler-Straße 3, 72076 Tübingen, Germany.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Nikolaou
authors.affiliation: Department of diagnostic and interventional neuroradiology, RWTH Aachen university, 52074 Aachen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Wiesmann
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000528:radiation effects*; D003287:Contrast Media; D006801:Humans; D007091:Image Processing, Computer-Assisted; D055420:Perfusion Imaging / Q000009:adverse effects / Q000379:methods*; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted; D014057:Tomography, X-Ray Computed / Q000009:adverse effects / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: Low-dose perfusion CT; Perfusion CT; Radiation dose; Stroke