title: Enantioselective Synthesis of Highly Substituted Chromans via the Oxa-Michael-Michael Cascade Reaction with a Bifunctional Organocatalyst.
abstract: A highly enantioselective synthesis of chiral chroman derivatives via an oxa-Michael-Michael cascade reaction has been developed using a bifunctional thiourea organocatalyst. The products were obtained with excellent enantioselectivities (up to >99%), good yields (up to 95%), and diastereoselectivities (up to 5:1).
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal 462066, India.
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Saha
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal 462066, India.
authors.forename: Arnab
authors.initials: A
authors.lastname: Biswas
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal 462066, India.
authors.forename: Nagaraju
authors.initials: N
authors.lastname: Molleti
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal 462066, India.|Department of Chemistry, Indian Institute of Technology , Kanpur 208016, India.
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh