title: The structural connectivity of the recurrent transient global amnesia.
abstract: BACKGROUND
  One of recent interesting hypotheses of transient global amnesia (TGA) pathophysiology is the preexisting vulnerability of the memory network in patients with TGA.
  
  
  OBJECTIVE
  To verify the hypothesis that patients with recurrent amnestic attacks may have more disrupted structural connectivity than patients of a single TGA event, we compared the brain imaging of patients with repeated episodes of TGA with those who experienced a single attack.
  
  
  METHODS
  Seven patients who were having recurrent TGA and 14 age- and sex-matched control subjects who had only a single episode of TGA participated in the study. Diffusion tensor images from both groups were assessed and analyzed using tract-based spatial statistics.
  
  
  RESULTS
  The fractional anisotropy and mean diffusivity values were not reduced in any lesion within the memory pathway of recurrent patient group when compared with those of single event group.
  
  
  CONCLUSIONS
  No disruptions in the structural connectivity of the memory pathway were observed in patients with recurrent TGA attacks, refuting the hypothesis that recurrent TGA patients present predisposing weakness of the memory network. The stability of structural connectivity suggests that repeated hippocampal lesions associated with TGA do not affect the microstructure of the brain.
authors.affiliation: Department of Neurology, Konkuk University Medical Center, Seoul, Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Moon
authors.affiliation: Department of Radiology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: W-J
authors.initials: WJ
authors.lastname: Moon
authors.affiliation: Department of Neurology, Konkuk University Medical Center, Seoul, Korea.|Center for Geriatric Neuroscience Research, Institute of Biomedical Science, Konkuk Medical Science Research Center, Seoul, Korea.
authors.forename: S-H
authors.initials: SH
authors.lastname: Han
mesh_terms: D000368:Aged; D020236:Amnesia, Transient Global / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
keywords: amnesia; imaging; memory