title: Vesicular control of fusion pore expansion.
abstract: Exocytic post-fusion events play an important role determining the composition and quantity of cellular secretion. In particular, Ca(2+)-dependent regulation of fusion pore dilation/closure is a key regulator for fine-tuning vesicle content secretion. This requires a tight temporal and spatial integration of vesicle fusion with the PM, Ca(2+) signals and translation of the Ca(2+) signal into fusion pore dilation via auxiliary factors. Yet, it is still mostly elusive how this is achieved in slow and non-excitable secretory cells, where initial Ca(2+) signals triggering fusions will abate before onset of the post-fusion phase. New results suggest, that the vesicles themselves provide the necessary itinerary to sense and link vesicle fusion to generation of local Ca(2+) signals and fusion pore expansion.
authors.affiliation: Institute of General Physiology; University of Ulm ; Ulm, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Neuland
authors.affiliation: Institute of General Physiology; University of Ulm ; Ulm, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Frick
keywords: P2X4; calcium; complexin; exocytosis; fusion pore; lamellar body; secretion; synaptotagmin-7