title: The Utility of the Addenbrooke's Cognitive Examination Version Three in Early-Onset Dementia.
abstract: OBJECTIVE
  Early-onset dementia (EOD) is defined as functionally relevant cognitive decline with age of onset at less than 65 years. The aim of this study was to investigate the utility of the recently validated third version of the Addenbrooke's Cognitive Examination (ACE-III) in predicting dementia diagnoses in EOD.
  
  
  METHODS
  ACE-III scores of EOD patients were compared to those of healthy controls (HC) and individuals with subjective memory impairment (SMI).
  
  
  RESULTS
  The study included 71 EOD patients (Alzheimer's disease, n = 31; primary progressive aphasia, n = 11; behavioural-variant frontotemporal dementia, n = 18, and posterior cortical atrophy, n = 11); there were 28 HC and 15 individuals with SMI. At a cut-off score of 88/100, the ACE-III displayed high sensitivity and specificity in distinguishing EOD from HC (91.5 and 96.4%) and SMI (91.5 and 86.7%).
  
  
  CONCLUSIONS
  The ACE-III is a reliable cognitive screening tool in EOD.
authors.affiliation: Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK.
authors.forename: Marwa
authors.initials: M
authors.lastname: Elamin
authors.forename: Guy
authors.initials: G
authors.lastname: Holloway
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Bak
authors.forename: Suvankar
authors.initials: S
authors.lastname: Pal
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis; D009483:Neuropsychological Tests; D015203:Reproducibility of Results