title: Precolectomy Therapy Does Not Alter Histologic Findings Distribution in Resected Colon in Pediatric Ulcerative Colitis.
abstract: Medically intractable pediatric ulcerative colitis can lead to colectomy after which patients commonly receive an ileoanal pouch. Postoperative complications are more common in patients with Crohn disease, a diagnosis that may be rendered after the colectomy specimen is examined. Because most children are likely to be exposed to medications before colectomy, we sought to examine whether such exposure influences the distribution of the inflammation within the resected colon and therefore potentially raise questions about the diagnosis accuracy.
  
  
  
  We conducted a retrospective cohort study of 32 pediatric ulcerative colitis cases undergoing colectomy from 2007 to 2014 for clinical data and precolectomy treatment history. The resected colon histology was reviewed independently by 2 blinded pathologists. The acute/active inflammation was scored using the modified Riley score for 3 colonic segments (proximal, transverse, and distal colon) for each patient. Linear mixed-effects models were used to evaluate possible association between acute/active inflammation scores at various sites and medication use.
  
  
  
  Twelve cases (38%) showed decreasing acute inflammation score distally to proximally, 8 (25%) had increasing scores, and 12 cases showed no change. Patients were most commonly exposed to corticosteroids, followed by anti-tumor necrosis factor antibodies. There was no statistically or clinically significant change in the histologic scores across the colonic segments of the resected colon in association with exposure to any specific medication or combination of medications, sex, age at diagnosis and surgery, or duration of disease.
  
  
  
  Precolectomy therapy does not seem to influence the distribution of inflammation within the resected colon.
authors.affiliation: *Inflammatory Bowel Disease Center, Division of Gastroenterology, Seattle Children's Hospital, University of Washington †Laboratory Medicine, Anatomic and Clinical Pathology, Seattle Children's Hospital, University of Washington ‡Seattle Children's Core for Biomedical Statistics, Seattle Children's Research Institute, Seattle Children's Hospital, University of Washington §Department of Laboratories, Seattle Children's Hospital, University of Washington.
authors.forename: Ghassan T
authors.initials: GT
authors.lastname: Wahbeh
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Lawless
authors.forename: David L
authors.initials: DL
authors.lastname: Suskind
authors.forename: Michele L
authors.initials: ML
authors.lastname: Shaffer
authors.forename: Bonnie
authors.initials: B
authors.lastname: Cole
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003082:Colectomy / Q000379:methods; D003093:Colitis, Ulcerative / Q000473:pathology / Q000601:surgery*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007223:Infant; D008297:Male; D011183:Postoperative Complications; D011300:Preoperative Care; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D007155:Immunologic Factors; D007166:Immunosuppressive Agents