title: Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event.
abstract: OBJECTIVE
  According to the European license, alteplase can be given no sooner than 3 months after previous stroke. However, it is not known whether past history of stroke influences the effect of treatment. Our aim was to evaluate safety and functional outcome after intravenous thrombolysis administered in everyday practice to patients with previous stroke≤3 months compared with those with first-ever stroke.
  
  
  METHODS
  We analyzed consecutive cases treated with alteplase between October 2003 and July 2014 contributed to the Safe Implementation of Thrombolysis for Stroke-Eastern Europe registry from 12 countries. Odds ratios were calculated using unadjusted and adjusted logistic regression.
  
  
  RESULTS
  Of 13,007 patients, 11,221 (86%) had no history of stroke and 249 (2%) experienced previous stroke≤3 months before admission. Patients with previous stroke≤3 months had a higher proportion of hypertension and hyperlipidemia. There were no significant differences in outcome, including symptomatic intracerebral hemorrhage according to European Cooperative Acute Stroke Study (unadjusted odds ratio 1.27, 95% confidence interval: 0.74-2.15), and being alive and independent at 3 months (odds ratio 0.81, 95% confidence interval: 0.61-1.09).
  
  
  CONCLUSIONS
  Patients currently treated with alteplase, despite a history of previous stroke≤3 months, do not seem to achieve worse outcome than those with first-ever stroke. Although careful patient selection was probably of major importance, our findings provide reassurance that this group of patients may safely benefit from thrombolysis and should not be arbitrarily excluded as a whole. Further studies are needed to identify the shortest safe time lapse from the previous event to treatment with alteplase.
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Michal
authors.initials: M
authors.lastname: Karlinski
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Adam
authors.initials: A
authors.lastname: Kobayashi
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.). czlonkow
authors.forename: Anna
authors.initials: A
authors.lastname: Czlonkowska
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Robert
authors.initials: R
authors.lastname: Mikulik
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Daniel
authors.initials: D
authors.lastname: Vaclavik
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Miroslav
authors.initials: M
authors.lastname: Brozman
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Gdovinova
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Viktor
authors.initials: V
authors.lastname: Švigelj
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Laszlo
authors.initials: L
authors.lastname: Csiba
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Klara
authors.initials: K
authors.lastname: Fekete
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Janika
authors.initials: J
authors.lastname: Kõrv
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Vida
authors.initials: V
authors.lastname: Demarin
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Vanja
authors.initials: V
authors.lastname: Bašic-Kes
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Aleksandras
authors.initials: A
authors.lastname: Vilionskis
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Dalius
authors.initials: D
authors.lastname: Jatuzis
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Yakup
authors.initials: Y
authors.lastname: Krespi
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Nikolay
authors.initials: N
authors.lastname: Shamalov
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Silva
authors.initials: S
authors.lastname: Andonova
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Niaz
authors.initials: N
authors.lastname: Ahmed
authors.affiliation: From the 2nd Department of Neurology (M.K., A.K., A.C.), and Interventional Stroke and Cerebrovascular Treatment Centre (A.K.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland (A.C.); International Clinical Research Center and Neurology Department, St Anne's Hospital in Brno and Masaryk University, Brno, Czech Republic (R.M.); Neurology Department, Ostava-Vítkovice Hospital, Research and Training Institute, Ostrava Czech Republic (D.V.); Neurology Department, University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia (M.B.); Department of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovakia (Z.G.); Department of Vascular Neurology and Neurological Intensive Care, University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.Š.); Department of Neurology, Medical and Health Science Center, University of Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia (V.D.); Department of Neurology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia (V.B.-K.); Department of Neurology and Neurosurgery, Vilnius University and Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center, Istanbul, Turkey (Y.K.); Department of Neurology and Neurosurgery, Pirogov Russian National Medical University, Moscow, Russia (N.S.); Department of Neurological Diseases, Faculty of Medicine, Medical University of Varna, Bulgaria (S.A.); and Department of Neurology, Karolinska University Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (N.A., N.W.).
authors.forename: Nils
authors.initials: N
authors.lastname: Wahlgren
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D015331:Cohort Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012008:Recurrence; D012189:Retrospective Studies; D020521:Stroke / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D015912:Thrombolytic Therapy / Q000379:methods; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: acute stroke; alteplase; off-label use; recurrence; thrombolysis; treatment outcome