title: S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors.
abstract: An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. phliang@ntu.edu.tw.
authors.forename: Hsien-Wei
authors.initials: HW
authors.lastname: Yeh
authors.forename: Tzung-Sheng
authors.initials: TS
authors.lastname: Lin
authors.forename: Hsiao-Wen
authors.initials: HW
authors.lastname: Wang
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Cheng
authors.forename: Der-Zen
authors.initials: DZ
authors.lastname: Liu
authors.forename: Pi-Hui
authors.initials: PH
authors.lastname: Liang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000502:physiology; D007251:Influenza, Human / Q000188:drug therapy / Q000821:virology; D008081:Liposomes; D008823:Micelles; D009844:Oligosaccharides / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000821:virology; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D008081:Liposomes; D008823:Micelles; D009844:Oligosaccharides; C016735:sialooligosaccharides