title: Riceabetes: is the association of type 2 diabetes with rice intake due to a high carbohydrate intake or due to exposure to excess inorganic arsenic?
abstract: A high intake of rice is associated with a high incidence and prevalence of diabetes. While this may be partially due to the high glycemic index carbohydrate content, it may also be due to a high arsenic level found in rice. Arsenic increases insulin resistance and decreases beta-cell function through oxidative stress, high cytokine levels, activation of NF-kappa B and increased amyloid formation in the pancreatic beta cells.
authors.affiliation: a Southside Endocrinology and University of Alabama at Birmingham , Birmingham , AL , USA.
authors.forename: David S H
authors.initials: DS
authors.lastname: Bell
mesh_terms: D001151:Arsenic / Q000633:toxicity*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced* / Q000503:physiopathology; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D005506:Food Contamination; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism; D012275:Oryza / Q000009:adverse effects* / Q000737:chemistry*; D018384:Oxidative Stress / Q000502:physiology
chemical_list: D004040:Dietary Carbohydrates; D001151:Arsenic
keywords: Rice intake; beta-cell dysfunction; high arsenic levels; insulinresistance; type 2 diabetes