title: Characteristic responses of a phospholipid molecular layer to polyols.
abstract: Polyols (sugar alcohols) are widely used in foods, pharmaceutical formulations and cosmetics, and therefore it is important to understand their effects on cell membranes and skin. To address this issue, we examined the effect of polyols (1,2-ethanediol (ethylene glycol), 1,3-butanediol, 1,2,3-propanetriol (glycerol), and 1,2,3,4-butanetetraol) on artificial membrane systems (liposomes, monolayers, or dry films) prepared from phospholipid (1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)). 1,2-Ethanediol and 1,3-butanediol had little effect on the size of the DMPC liposomes or the surface pressure (π)-surface area (A) isotherm of DMPC monolayers at an air-water interface, whereas 1,2,3-propanetriol or 1,2,3,4-butanetetraol increased both liposome size and surface pressure. Attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR) and differential scanning calorimetry (DSC) were used to evaluate the interaction between DMPC and polyols. These experimental results suggest that the chemical structure of polyol plays an important role in the characteristic interaction between polyol and DMPC.
authors.affiliation: Graduate School of Science, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526, Japan; Japan Science and Technology Agency, CREST, Tokyo, Japan. Electronic address: nakatas@hiroshima-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakata
authors.affiliation: Graduate School of Science, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Deguchi
authors.affiliation: Graduate School of Science, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526, Japan.
authors.forename: Yota
authors.initials: Y
authors.lastname: Seki
authors.affiliation: Graduate School of Science, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Furuta
authors.affiliation: Graduate School of Science, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Fukuhara
authors.affiliation: Graduate School of Science, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526, Japan.
authors.forename: Sadafumi
authors.initials: S
authors.lastname: Nishihara
authors.affiliation: Graduate School of Science, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Nakanarusawa, Hitachi, Ibaraki 316-8511, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kumazawa
authors.affiliation: Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Nakanarusawa, Hitachi, Ibaraki 316-8511, Japan.
authors.forename: Shun
authors.initials: S
authors.lastname: Mashiko
authors.affiliation: Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Nakanarusawa, Hitachi, Ibaraki 316-8511, Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Fujihira
authors.affiliation: Japan Science and Technology Agency, CREST, Tokyo, Japan; Shiseido Research Center, 2-2-1Hayabuchi, Tsuzuki-ku, Yokohama 224-8558, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Goto
authors.affiliation: Japan Science and Technology Agency, CREST, Tokyo, Japan; Shiseido Research Center, 2-2-1Hayabuchi, Tsuzuki-ku, Yokohama 224-8558, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Denda
mesh_terms: D010743:Phospholipids / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D010743:Phospholipids; D011108:Polymers; C024617:polyol
keywords: Attenuated total reflection; Differential scanning calorimetry; Fourier transform infrared spectroscopy; Liposome; Phospholipid molecular layer; Polyol; Surface pressure isotherm