title: Low-cost bioanalysis on paper-based and its hybrid microfluidic platforms.
abstract: Low-cost assays have broad applications ranging from human health diagnostics and food safety inspection to environmental analysis. Hence, low-cost assays are especially attractive for rural areas and developing countries, where financial resources are limited. Recently, paper-based microfluidic devices have emerged as a low-cost platform which greatly accelerates the point of care (POC) analysis in low-resource settings. This paper reviews recent advances of low-cost bioanalysis on paper-based microfluidic platforms, including fully paper-based and paper hybrid microfluidic platforms. In this review paper, we first summarized the fabrication techniques of fully paper-based microfluidic platforms, followed with their applications in human health diagnostics and food safety analysis. Then we highlighted paper hybrid microfluidic platforms and their applications, because hybrid platforms could draw benefits from multiple device substrates. Finally, we discussed the current limitations and perspective trends of paper-based microfluidic platforms for low-cost assays.
authors.affiliation: Department of Chemistry, University of Texas at El Paso, 500 West University Ave, El Paso, TX 79968, USA.
authors.forename: Maowei
authors.initials: M
authors.lastname: Dou
authors.affiliation: Department of Chemistry, University of Texas at El Paso, 500 West University Ave, El Paso, TX 79968, USA.
authors.forename: Sharma Timilsina
authors.initials: ST
authors.lastname: Sanjay
authors.affiliation: OndaVia Inc, Hayward, CA 94545, USA.
authors.forename: Merwan
authors.initials: M
authors.lastname: Benhabib
authors.affiliation: The MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China; Bioinspired Engineering and Biomechanics Center, Xi' an Jiaotong University, Xi' an 710049, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Chemistry, University of Texas at El Paso, 500 West University Ave, El Paso, TX 79968, USA; Department of Biomedical Engineering, University of Texas at El Paso, 500 West University Ave, El Paso, TX 79968, USA; Border Biomedical Research Center, University of Texas at El Paso, 500 West University Ave, El Paso, TX 79968, USA. Electronic address: xli4@utep.edu.
authors.forename: XiuJun
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D002623:Chemistry Techniques, Analytical / Q000191:economics* / Q000295:instrumentation / Q000379:methods*; D003365:Costs and Cost Analysis; D006801:Humans; D056656:Lab-On-A-Chip Devices / Q000191:economics*; D010209:Paper; D018511:Systems Integration
keywords: Disease diagnosis; Food safety analysis; Low-cost bioassays; Paper hybrid microfluidic platform; Paper-based microfluidic lab-on-a-chip