title: Flipping a Lipid-Linked Oligosaccharide? You Must Whip It!
abstract: The mechanism for flipping large lipid-linked oligosaccharides across membranes has remained a paradox. Perez et al. now report the structure of the PglK protein of C. jejuni, a flippase for a bacterial lipid-linked oligosaccharide, and reveal an unexpected whip-like mechanism.
authors.affiliation: Department Pharmacology, UT-Southwestern Medical Center at Dallas, Dallas, TX, USA. Electronic address: mark.lehrman@utsouthwestern.edu.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lehrman
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000737:chemistry* / Q000378:metabolism*; D055162:Biocatalysis; D016123:Campylobacter jejuni / Q000201:enzymology*; D008070:Lipopolysaccharides / Q000378:metabolism*
chemical_list: D018528:ATP-Binding Cassette Transporters; D008070:Lipopolysaccharides
keywords: dolichol; flippase; lipid-linked oligosaccharide; polyisoprenol; undecaprenol