title: [Correlation factors of lymph node metastasis in patients with clinical stage T1a non-small cell lung cancer].
abstract: OBJECTIVE
  To explore the relationship between the lymph node metastasis and clinicopathological features in patients with clinical stage T1a non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Clinicopathological data of a total of 418 patients who underwent lobectomy and systematic lymph node dissection were retrospectively analyzed. Logistic regression was used to analyze the relationship between lymph node metastasis and clinicopathological features.
  
  
  RESULTS
  Lymph node metastasis was observed in 25 patients. There were 122 patients who were diagnosed as ground glass opacity with no lymph node metastasis. 399 patients had subcarinal dissection, among them 7 patients were found to have lymph node metastasis. Univariate analysis showed that gender, smoking history, diameter of lymph node, ground glass opacity (GGO), differentiation of the tumor and tumor site were the factors affecting lymph node metastasis (all P < 0.05). Logistic regression analysis showed that diameter of lymph node, differentiation of the tumor and the site of lesion were independent risk factors for lymph node metastasis of NSCLC.
  
  
  CONCLUSIONS
  Tumor in the left lung, poor differentiation, and diameter of lymph nodes ≥ 1 cm on the preoperative CT image are independent risk factors for lymph node metastasis of NSCLC, hence we should pay attention before surgery and systematic lymph node dissection should be done. For patients with poor differentiation and lymph nodes ≥ 1 cm, subcarinal lymph nodes dissection is recommended for the sake of higher possibility of lymph node metastasis. For patients with ground glass opacity ≤ 2 cm, the lymph node metastasis is extremely rare, therefore, selective lymph node dissection is reconmmended.
authors.forename: Zang
authors.initials: Z
authors.lastname: Ruochuan
authors.forename: Guo
authors.initials: G
authors.lastname: Shugeng
authors.forename: He
authors.initials: H
authors.lastname: Jie
authors.forename: Mao
authors.initials: M
authors.lastname: Yousheng
authors.forename: Xue
authors.initials: X
authors.lastname: Qi
authors.forename: Wang
authors.initials: W
authors.lastname: Dali
authors.forename: Mu
authors.initials: M
authors.lastname: Juwei
authors.forename: Zhao
authors.initials: Z
authors.lastname: Jun
authors.forename: Wang
authors.initials: W
authors.lastname: Yonggang
authors.forename: Liu
authors.initials: L
authors.lastname: Xiangyang
authors.forename: Tan
authors.initials: T
authors.lastname: Fengwei
authors.forename: Zhao
authors.initials: Z
authors.lastname: Gefei
authors.forename: Zhang
authors.initials: Z
authors.lastname: Qian
authors.forename: Zhang
authors.initials: Z
authors.lastname: Moyan
authors.forename: Song
authors.initials: S
authors.lastname: Peng
mesh_terms: D000704:Analysis of Variance; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D002454:Cell Differentiation; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking