title: MRI correlates of general intelligence in neurotypical adults.
abstract: There is growing interest in the neurobiological substrate of general intelligence. Psychometric estimates of general intelligence are reduced in a range of neurological disorders, leading to practical application as sensitive, but non-specific, markers of cerebral disorder. This study examined estimates of general intelligence in neurotypical adults using diffusion tensor imaging and resting-state functional connectivity analysis. General intelligence was related to white matter organisation across multiple brain regions, confirming previous work in older healthy adults. We also found that variation in general intelligence was related to a large functional sub-network involving all cortical lobes of the brain. These findings confirm that individual variance in general intelligence is related to diffusely represented brain networks.
authors.affiliation: Melbourne Brain Centre, Royal Melbourne Hospital, VIC, Australia; Melbourne School of Psychological Sciences, University of Melbourne, VIC, Australia; Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia; Developmental Imaging, Murdoch Children's Research Institute, VIC, Australia. Electronic address: charles.malpas@unimelb.edu.au.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Malpas
authors.affiliation: Melbourne Brain Centre, Royal Melbourne Hospital, VIC, Australia; Developmental Imaging, Murdoch Children's Research Institute, VIC, Australia; Department of Radiology, University of Melbourne, VIC, Australia.
authors.forename: Sila
authors.initials: S
authors.lastname: Genc
authors.affiliation: Melbourne School of Psychological Sciences, University of Melbourne, VIC, Australia; Department of Neuropsychology, Austin Health, VIC, Australia; Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Austin Hospital, VIC, Australia.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Saling
authors.affiliation: Melbourne Brain Centre, Royal Melbourne Hospital, VIC, Australia; Melbourne Neuropsychiatry Centre, Royal Melbourne Hospital, VIC, Australia; Department of Psychiatry, University of Melbourne, VIC, Australia.
authors.forename: Dennis
authors.initials: D
authors.lastname: Velakoulis
authors.affiliation: Melbourne Brain Centre, Royal Melbourne Hospital, VIC, Australia; Department of Radiology, University of Melbourne, VIC, Australia; Department of Medical Imaging, Royal Melbourne Hospital, VIC, Australia.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Desmond
authors.affiliation: Melbourne Brain Centre, Royal Melbourne Hospital, VIC, Australia; Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia.
authors.forename: Terence J
authors.initials: TJ
authors.lastname: O'Brien
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology; D066127:White Matter / Q000033:anatomy & histology
keywords: Diffusion MRI; Functional connectivity; General intelligence; IQ; Resting state; White matter