title: Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications.
abstract: Many molecular mechanisms underlie the changes in synaptic glutamate receptor content that are required by neuronal networks to generate cellular correlates of learning and memory. During the last decade, posttranslational modifications have emerged as critical regulators of synaptic transmission and plasticity. Notably, phosphorylation, ubiquitination, and palmitoylation control the stability, trafficking, and synaptic expression of glutamate receptors in the central nervous system. In the current review, we will summarize some of the progress made by the neuroscience community regarding our understanding of phosphorylation, ubiquitination, and palmitoylation of the NMDA and AMPA subtypes of glutamate receptors.
authors.affiliation: From the Département de Chimie, Université du Québec à Montréal, Montréal, Québec H3C 3P8, Canada.
authors.forename: Marc P
authors.initials: MP
authors.lastname: Lussier
authors.affiliation: the Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, and.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sanz-Clemente
authors.affiliation: the Receptor Biology Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892 rochek@ninds.nih.gov.
authors.forename: Katherine W
authors.initials: KW
authors.lastname: Roche
mesh_terms: D000818:Animals; D006801:Humans; D054878:Lipoylation / Q000502:physiology*; D010766:Phosphorylation / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D018091:Receptors, AMPA / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D054875:Ubiquitination / Q000502:physiology*
chemical_list: D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate
keywords: N-methyl-D-aspartate receptor (NMDA receptor, NMDAR); alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor, AMPAR); glutamate receptor; post-translational modification (PTM); protein palmitoylation; ubiquitin