title: Cp*Co(III)-Catalyzed Annulations of 2-Alkenylphenols with CO: Mild Access to Coumarin Derivatives.
abstract: Cp*Co(III)-catalyzed annulations of 2-alkenylphenols with CO for the synthesis of coumarin derivatives have been developed. The reaction features mild reaction conditions, broad substrate scope, and good functional group tolerance. Preliminary mechanistic studies were conducted, suggesting that C-H activation is the turnover limiting step. Furthermore, the efficiency of this reaction was demonstrated by the rapid total synthesis of three natural products herniarin, xanthyletin, and seselin.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, China.
authors.forename: Xu-Ge
authors.initials: XG
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, China.
authors.forename: Shang-Shi
authors.initials: SS
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, China.
authors.forename: Chun-Yong
authors.initials: CY
authors.lastname: Jiang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, China.
authors.forename: Jia-Qiang
authors.initials: JQ
authors.lastname: Wu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, China.
authors.forename: Qingjiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou, 510006, China.
authors.forename: Honggen
authors.initials: H
authors.lastname: Wang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D014468:Umbelliferones / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000475:Alkenes; D001688:Biological Products; D003374:Coumarins; D010636:Phenols; D014468:Umbelliferones; D003035:Cobalt; C020814:xanthyletine; C007929:herniarin; C516746:seselin