title: Glycosylation-directed quality control of protein folding.
abstract: Membrane-bound and soluble proteins of the secretory pathway are commonly glycosylated in the endoplasmic reticulum. These adducts have many biological functions, including, notably, their contribution to the maturation of glycoproteins. N-linked glycans are of oligomeric structure, forming configurations that provide blueprints to precisely instruct the folding of protein substrates and the quality control systems that scrutinize it. O-linked mannoses are simpler in structure and were recently found to have distinct functions in protein quality control that do not require the complex structure of N-linked glycans. Together, recent studies reveal the breadth and sophistication of the roles of these glycan-directed modifications in protein biogenesis.
authors.affiliation: Temasek Life Sciences Laboratory, National University of Singapore, 1 Research Link, Singapore 117604.|Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543.
authors.forename: Chengchao
authors.initials: C
authors.lastname: Xu
authors.affiliation: Temasek Life Sciences Laboratory, National University of Singapore, 1 Research Link, Singapore 117604.|Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543.|Duke University-National University of Singapore Graduate Medical School, 8 College Road, Singapore 169857.
authors.forename: Davis T W
authors.initials: DT
authors.lastname: Ng
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006023:Glycoproteins / Q000737:chemistry*; D006031:Glycosylation; D006801:Humans; D011134:Polysaccharides / Q000737:chemistry*; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D012568:Schizosaccharomyces / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D011134:Polysaccharides