title: Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis.
abstract: Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.
authors.forename: Alain S
authors.initials: AS
authors.lastname: Leutou
authors.forename: Inho
authors.initials: I
authors.lastname: Yang
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Seo
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego , La Jolla, California 92093-0204, United States.
authors.forename: William
authors.initials: W
authors.lastname: Fenical
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002140:California; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012486:Salmonella typhimurium / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D007093:Imidazoles; C000605717:nocarimidazole A; C000605718:nocarimidazole B; C098330:4-aminoimidazole