title: Fluoride Exposure, Follicle Stimulating Hormone Receptor Gene Polymorphism and Hypothalamus-pituitary-ovarian Axis Hormones in Chinese Women.
abstract: The effects of fluoride exposure on the functions of reproductive and endocrine systems have attracted widespread attention in academic circle nowadays. However, it is unclear whether the gene-environment interaction may modify the secretion and activity of hypothalamus-pituitary- ovarian (HPO) axis hormones. Thus, the aim of this study was to explore the influence of fluoride exposure and follicle stimulating hormone receptor (FSHR) gene polymorphism on reproductive hormones in Chinese women. A cross sectional study was conducted in seven villages of Henan Province, China during 2010-2011. A total of 679 women aged 18-48 years were recruited through cluster sampling and divided into three groups, i.e. endemic fluorosis group (EFG), defluoridation project group (DFPG), and control group (CG) based on the local fluoride concentration in drinking water. The serum levels of gonadotropin releasing hormone (GnRH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) were determined respectively and the FSHR polymorphism was detected by real time PCR assay. The results provided the preliminary evidence indicating the gene-environment interaction on HPO axis hormones in women.
authors.affiliation: Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Ming Xu
authors.initials: MX
authors.lastname: Zhao
authors.affiliation: Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Guo Yu
authors.initials: GY
authors.lastname: Zhou
authors.affiliation: Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Jing Yuan
authors.initials: JY
authors.lastname: Zhu
authors.affiliation: Department of Endemic Disease, Kaifeng Center for Disease Control and Prevention, Kaifeng 475000, Henan, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Gong
authors.affiliation: Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Jia Xiang
authors.initials: JX
authors.lastname: Hou
authors.affiliation: Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Li Ju
authors.initials: LJ
authors.lastname: Duan
authors.affiliation: Department of Endemic Disease, Kaifeng Center for Disease Control and Prevention, Kaifeng 475000, Henan, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Liu Xin
authors.initials: LX
authors.lastname: Cui
authors.affiliation: Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Ba
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044466:Asian People; D002681:China; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005457:Fluoridation / Q000009:adverse effects; D005459:Fluorides / Q000008:administration & dosage / Q000009:adverse effects* / Q000652:urine; D005640:Follicle Stimulating Hormone / Q000097:blood; D059647:Gene-Environment Interaction; D007987:Gonadotropin-Releasing Hormone / Q000097:blood; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D010053:Ovary / Q000502:physiology; D010902:Pituitary Gland / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D011962:Receptors, FSH / Q000235:genetics*; D014028:Tobacco Smoke Pollution; D055815:Young Adult
chemical_list: D011962:Receptors, FSH; D014028:Tobacco Smoke Pollution; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005459:Fluorides