title: Study on the effects of microencapsulated Lactobacillus delbrueckii on the mouse intestinal flora.
abstract: OBJECTIVE
  To evaluate the protective effects of microencapsulation on Lactobacillus delbrueckii by random, parallel experimental design.
  
  
  METHODS
  Lincomycin hydrochloride-induced intestinal malfunction mouse model was successfully established; then the L. delbrueckii microcapsule was given to the mouse. The clinical behaviour, number of intestinal flora, mucous IgA content in small intestine, IgG and IL-2 level in peripheral blood were monitored. The histological sections were also prepared.
  
  
  RESULTS
  The L. delbrueckii microcapsule could have more probiotic effects as indicated by higher bifidobacterium number in cecal contents. The sIgA content in microcapsule treated group was significantly higher than that in non-encapsulated L. delbrueckii treated group (p < 0.05). Intestine pathological damage of the L. delbrueckii microcapsule-treated group showed obvious restoration.
  
  
  CONCLUSIONS
  The L. delbrueckii microcapsules could relieve the intestinal tissue pathological damage and play an important role in curing antibiotic-induced intestinal flora dysfunction.
authors.affiliation: a College of Life Science, University Key Laboratory of Microbiology, Heilongjiang University , Harbin , China and.|b Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education , Harbin , China.
authors.forename: Qingshen
authors.initials: Q
authors.lastname: Sun
authors.affiliation: a College of Life Science, University Key Laboratory of Microbiology, Heilongjiang University , Harbin , China and.
authors.forename: Yue
authors.initials: Y
authors.lastname: Shi
authors.affiliation: a College of Life Science, University Key Laboratory of Microbiology, Heilongjiang University , Harbin , China and.
authors.forename: Fuying
authors.initials: F
authors.lastname: Wang
authors.affiliation: a College of Life Science, University Key Laboratory of Microbiology, Heilongjiang University , Harbin , China and.|b Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education , Harbin , China.
authors.forename: Dequan
authors.initials: D
authors.lastname: Han
authors.affiliation: a College of Life Science, University Key Laboratory of Microbiology, Heilongjiang University , Harbin , China and.
authors.forename: Hong
authors.initials: H
authors.lastname: Lei
authors.affiliation: a College of Life Science, University Key Laboratory of Microbiology, Heilongjiang University , Harbin , China and.|b Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education , Harbin , China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a College of Life Science, University Key Laboratory of Microbiology, Heilongjiang University , Harbin , China and.
authors.forename: Quan
authors.initials: Q
authors.lastname: Sun
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D058491:Bacterial Load; D001644:Bifidobacterium; D001835:Body Weight / Q000187:drug effects; D004339:Drug Compounding; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007376:Interleukin-2 / Q000097:blood; D007410:Intestinal Diseases / Q000139:chemically induced / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D048668:Lactobacillus delbrueckii; D008034:Lincomycin / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009092:Mucous Membrane / Q000737:chemistry; D009929:Organ Size / Q000187:drug effects; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007376:Interleukin-2; D008034:Lincomycin
keywords: Histological observation; Lactobacillus delbrueckii microcapsule; immune factors; in vivo