title: The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.
abstract: The structure of death receptor 4 (DR4) in complex with TNF-related apoptosis-inducing ligand (TRAIL) has been determined at 3 Å resolution and compared with those of previously determined DR5-TRAIL complexes. Consistent with the high sequence similarity between DR4 and DR5, the overall arrangement of the DR4-TRAIL complex does not differ substantially from that of the DR5-TRAIL complex. However, subtle differences are apparent. In addition, solution interaction studies were carried out that show differences in the thermodynamics of binding DR4 or DR5 with TRAIL.
authors.affiliation: Molecular Structure and Design, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Vidhyashankar
authors.initials: V
authors.lastname: Ramamurthy
authors.affiliation: Protein Science, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Yamniuk
authors.affiliation: Protein Science, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Lawrence
authors.affiliation: Molecular Structure and Design, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Yong
authors.affiliation: Protein Science, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Lumelle A
authors.initials: LA
authors.lastname: Schneeweis
authors.affiliation: Protein Science, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Protein Science, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Murdock
authors.affiliation: Protein Science, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Corbett
authors.affiliation: Protein Science, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Doyle
authors.affiliation: Molecular Structure and Design, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Sheriff
mesh_terms: D000595:Amino Acid Sequence; D002151:Calorimetry; D003460:Crystallization; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000737:chemistry* / Q000302:isolation & purification; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000737:chemistry* / Q000302:isolation & purification; D013816:Thermodynamics
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand; C105190:TNFRSF10A protein, human; C505653:TNFSF10 protein, human
keywords: TNF-related apoptosis-inducing ligand; death receptor 4; death receptor 5