title: Does therapeutic hypothermia reduce acute kidney injury among term neonates with perinatal asphyxia?--a randomized controlled trial.
abstract: OBJECTIVE
  The objective of this study is to evaluate whether therapeutic hypothermia reduces the incidence of acute kidney injury (AKI) among term neonates perinatal asphyxia.
  
  
  METHODS
  This randomized controlled trial conducted in a tertiary care teaching hospital, south India included 120 term neonates with perinatal asphyxia who were randomized to receive either therapeutic hypothermia or standard supportive care. Renal parameters of neonates in both the groups were monitored and AKI was ascertained as per Acute Kidney Injury Network criteria.
  
  
  RESULTS
  The incidence of AKI was less in therapeutic hypothermia group compared to standard treatment group (32% versus 60%, p < 0.05). The incidence of Stages 1, 2, and 3 AKI was 22%, 5%, and 5% in therapeutic hypothermia group compared with 52%, 5%, and 3%, respectively, in the standard treatment group. The mortality was less in therapeutic hypothermia group compared with the standard treatment group (26% versus 50%, p < 0.05).
  
  
  CONCLUSIONS
  Therapeutic hypothermia reduces the incidence and severity of AKI among term neonates with perinatal asphyxia.
authors.affiliation: a Department of Neonatology and.
authors.forename: Vasanthan
authors.initials: V
authors.lastname: Tanigasalam
authors.affiliation: a Department of Neonatology and.
authors.forename: Vishnu
authors.initials: V
authors.lastname: Bhat
authors.affiliation: a Department of Neonatology and.
authors.forename: Bethou
authors.initials: B
authors.lastname: Adhisivam
authors.affiliation: b Department of Biochemistry , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India.
authors.forename: M G
authors.initials: MG
authors.lastname: Sridhar
mesh_terms: D058186:Acute Kidney Injury / Q000517:prevention & control*; D000328:Adult; D001238:Asphyxia Neonatorum / Q000628:therapy*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000379:methods*; D015994:Incidence; D007194:India; D007231:Infant, Newborn; D007677:Kidney Function Tests; D011247:Pregnancy
keywords: AKI; Acute kidney injury; neonate; perinatal asphyxia; therapeutic hypothermia