title: Sugar-coated signaling in follicular lymphoma.
abstract: In this issue of Blood, complementary studies by Amin et al and Linley et al demonstrate that sugar moieties linked to surface immunoglobulin (sIg) of follicular lymphoma (FL) cells directly interact with endogenous lectins within the lymphoma niche and lead to activation of downstream B-cell receptor (BCR) signaling pathways. In addition to providing further insight into the role of the microenvironment in lymphomagenesis, these findings expose a unique molecular interaction that may represent a viable target for therapeutic intervention.
authors.affiliation: YALE CANCER CENTER.
authors.forename: Matthew P
authors.identifier: http://orcid.org/0000-0002-9660-3652
authors.initials: MP
authors.lastname: Strout
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism*; D020013:Calcium Signaling; D015815:Cell Adhesion Molecules / Q000276:immunology* / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007135:Immunoglobulin Variable Region / Q000378:metabolism*; D037181:Lectins, C-Type / Q000276:immunology* / Q000378:metabolism*; D008224:Lymphoma, Follicular / Q000276:immunology* / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D008264:Macrophages / Q000276:immunology*; D008297:Male; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology* / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D015815:Cell Adhesion Molecules; D007075:Immunoglobulin M; D007135:Immunoglobulin Variable Region; D037181:Lectins, C-Type; D011947:Receptors, Antigen, B-Cell; D011956:Receptors, Cell Surface