title: Destruction and Construction: Application of Dearomatization Strategy in Aromatic Carbon-Nitrogen Bond Functionalization.
abstract: The formation of carbon-carbon bonds through the functionalization of aromatic carbon-nitrogen bonds is a highly attractive synthetic strategy in the synthesis of aromatic molecules. In this paper, we report a novel aromatic carbon-nitrogen bond functionalization reaction by using a simple dearomatization strategy. Through this process para-substituted anilines serve as a potential aryl source in the construction of a range of functionalized aromatic molecules, such as quaternary carbon centers, α-keto esters, and aldehydes.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 (China).
authors.forename: Shuo-En
authors.initials: SE
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 (China).
authors.forename: Linfei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 (China).
authors.forename: Qiuqin
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 (China). rhfan@fudan.edu.cn.
authors.forename: Renhua
authors.initials: R
authors.lastname: Fan
keywords: cyanides; dearomatization; functionalization of carbon-nitrogen bonds; quaternary carbon centers; synthetic methods