title: In vivo behaviors of Ca(OH)2 activated nano SiO2 (nCa/nSi=3) cement in rabbit model.
abstract: In vivo behaviors of Ca(OH)2 activated nano SiO2 (nCa/nSi=3, TCS) cement were investigated in the rabbit femoral defects using the poly(methyl methacrylate) (PMMA) as control. The deposited apatite and CaCO3 layers round TCS paste surfaces were completely used to construct the new bone tissue. TCS paste could stimulate the formation of new bone tissue in marrow tissue. The osteostimulation was mainly attributed to the proliferation and differentiation effects of Ca and Si ions released from TCS paste on the osteoprogenitor cells. However, Calcium-Silicate-Hydrate (C-S-H) gel in TCS paste was harder to degradate than Ca(OH)2. TCS paste kept the original shape during implantation, and could not provide the pores or spaces for further formation of bone tissue. Osteolytic defects induced by wear particles from TCS paste surface could not be completely avoided, because of the interfacial strain and the extensive micromotion between TCS paste surface and new bone tissue. Overall, our results indicated that Ca(OH)2 activated nano SiO2 cement was bioactivity and osteostimulation. The further improvements of Ca(OH)2 activated nano SiO2 cement should be done by achieving a balance between biological properties and mechanical performances.
authors.affiliation: School of Material Engineering, Jinling Institute of Technology, Nanjing 211169, China. Electronic address: lnqing@yahoo.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.affiliation: School of Material Engineering, Jinling Institute of Technology, Nanjing 211169, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lu
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China.
authors.forename: Xianghui
authors.initials: X
authors.lastname: Lan
authors.affiliation: Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province, Yancheng Institute of Technology, Yancheng 224051, China.
authors.forename: Guihua
authors.initials: G
authors.lastname: Hou
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China.
authors.forename: Zhongzi
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D001854:Bone Marrow Cells / Q000166:cytology; D002126:Calcium Hydroxide / Q000737:chemistry*; D049109:Cell Proliferation; D020007:Implants, Experimental; D007477:Ions; D059630:Mesenchymal Stem Cells / Q000166:cytology; D023421:Models, Animal; D053758:Nanoparticles / Q000737:chemistry*; D010014:Osteolysis / Q000473:pathology; D056951:Photoelectron Spectroscopy; D011817:Rabbits
chemical_list: D001843:Bone Cements; D007477:Ions; D002126:Calcium Hydroxide
keywords: Biocompatibility; Bone cement; Nano SiO(2); Osteostimulation