title: Hemoptysis due to aspirin treatment alternative to warfarin therapy in a patient with atrial fibrillation.
abstract: An 80-year-old female with a history of hypertension and atrial fibrillation had been receiving warfarin anticoagulant therapy and had stably maintained an international normalized ratio (INR) within the 2.0-3.0 range. Due to dental extractions, she was prescribed aspirin (100 mg/day) as an alternative therapy to warfarin. Three days later, the patient complained of hemoptysis without obvious inducement and the INR was 3.51. The aspirin was immediately discontinued and intravenous vitamin K was administered. Hemoptysis did not reappear and the INR returned to the normal limits. According to the Drug Interaction Probability Scale, a causal relationship between aspirin and warfarin and an increased INR value is possible.
authors.affiliation: Respiratory Department, the First Affiliated Hospital with Nanjing Medical University, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Song
authors.forename: Jia
authors.initials: J
authors.lastname: Cao
authors.forename: Yazhou
authors.initials: Y
authors.lastname: Xu
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Han
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
authors.forename: Xuefan
authors.initials: X
authors.lastname: Cui
mesh_terms: D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy*; D004347:Drug Interactions; D005260:Female; D006469:Hemoptysis / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D019934:International Normalized Ratio; D014081:Tooth Extraction; D014812:Vitamin K / Q000627:therapeutic use; D014859:Warfarin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014812:Vitamin K; D014859:Warfarin; D001241:Aspirin