title: Comparative Study of Anterior Eye Segment Measurements with Spectral Swept-Source and Time-Domain Optical Coherence Tomography in Eyes with Corneal Dystrophies.
abstract: OBJECTIVE
  To compare anterior eye segment measurements and morphology obtained with two optical coherence tomography systems (TD OCT, SS OCT) in eyes with corneal dystrophies (CDs).
  
  
  METHODS
  Fifty healthy volunteers (50 eyes) and 54 patients (96 eyes) diagnosed with CD (epithelial basement membrane dystrophy, EBMD = 12 eyes; Thiel-Behnke CD = 6 eyes; lattice CD TGFBI type = 15 eyes; granular CD type 1 = 7 eyes, granular CD type 2 = 2 eyes; macular CD = 23 eyes; and Fuchs endothelial CD = 31 eyes) were recruited for the study. Automated and manual central corneal thickness (aCCT, mCCT), anterior chamber depth (ACD), and nasal and temporal trabecular iris angle (nTIA, tTIA) were measured and compared with Bland-Altman plots.
  
  
  RESULTS
  Good agreement between the TD and SS OCT measurements was demonstrated for mCCT and aCCT in normal individuals and for mCCT in the CDs group. The ACD, nTIA, and tTIA measurements differed significantly in both groups. TBCD, LCD, and FECD caused increased CCT. MCD caused significant corneal thinning. FECD affected all analyzed parameters.
  
  
  CONCLUSIONS
  Better agreement between SS OCT and TD OCT measurements was demonstrated in normal individuals compared to the CDs group. OCT provides comprehensive corneal deposits analysis and demonstrates the association of CD with CCT, ACD, and TIA measurements.
authors.affiliation: Ophthalmology Clinic, Medical University of Silesia, 40-760 Katowice, Poland ; Department of Ophthalmology, Saint Barbara Hospital, 41-200 Sosnowiec, Poland.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Nowinska
authors.affiliation: Ophthalmology Clinic, Medical University of Silesia, 40-760 Katowice, Poland.
authors.forename: Sławomir J
authors.initials: SJ
authors.lastname: Teper
authors.affiliation: Ophthalmology Clinic, Medical University of Silesia, 40-760 Katowice, Poland ; Department of Ophthalmology, Saint Barbara Hospital, 41-200 Sosnowiec, Poland.
authors.forename: Dominika A
authors.initials: DA
authors.lastname: Janiszewska
authors.affiliation: Department of Ophthalmology, Saint Barbara Hospital, 41-200 Sosnowiec, Poland.
authors.forename: Anita
authors.initials: A
authors.lastname: Lyssek-Boron
authors.affiliation: Ophthalmology Clinic, Medical University of Silesia, 40-760 Katowice, Poland ; Department of Ophthalmology, Saint Barbara Hospital, 41-200 Sosnowiec, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Dobrowolski
authors.affiliation: Department of Biomedical Computer Systems, University of Silesia, Sosnowiec, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Koprowski
authors.affiliation: Ophthalmology Clinic, Medical University of Silesia, 40-760 Katowice, Poland.
authors.forename: Edward
authors.initials: E
authors.lastname: Wylegala
mesh_terms: D000293:Adolescent; D000328:Adult; D000869:Anterior Eye Segment / Q000033:anatomy & histology*; D016022:Case-Control Studies; D003317:Corneal Dystrophies, Hereditary / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D041623:Tomography, Optical Coherence / Q000379:methods