title: A Computational Approach for the Discovery of Protein-RNA Networks.
abstract: Protein-RNA interactions play important roles in a wide variety of cellular processes, ranging from transcriptional and posttranscriptional regulation of genes to host defense against pathogens. In this chapter we present the computational approach catRAPID to predict protein-RNA interactions and discuss how it could be used to find trends in ribonucleoprotein networks. We envisage that the combination of computational and experimental approaches will be crucial to unravel the role of coding and noncoding RNAs in protein networks.
authors.affiliation: Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003, Barcelona, Spain.|Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain.
authors.forename: Domenica
authors.initials: D
authors.lastname: Marchese
authors.affiliation: Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003, Barcelona, Spain.|Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain.
authors.forename: Carmen Maria
authors.initials: CM
authors.lastname: Livi
authors.affiliation: Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003, Barcelona, Spain. gian@tartaglialab.com.|Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain. gian@tartaglialab.com.|Institució Catalana de Recerca i Estudis Avançats (ICREA), 23 Passeig de Lluís Companys, 08010, Barcelona, Spain. gian@tartaglialab.com.
authors.forename: Gian Gaetano
authors.initials: GG
authors.lastname: Tartaglia
mesh_terms: D019295:Computational Biology / Q000379:methods*; D005786:Gene Expression Regulation / Q000235:genetics*; D053263:Gene Regulatory Networks; D062085:RNA, Long Noncoding / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D016601:RNA-Binding Proteins / Q000235:genetics*; D012261:Ribonucleoproteins / Q000235:genetics*; D012984:Software
chemical_list: D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins
keywords: Interaction prediction; Messenger RNA; Noncoding RNA; Protein–RNA interactions; Ribonucleoprotein networks; catRAPID