title: Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode.
abstract: The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry. Metformin hydrochloride shows an irreversible oxidation behavior over a wide interval of pH (Britton-Robinson buffers, pH 2-9). The peak current varied linearly in the range comprised between 8.0 × 10(-7) and 6.0 × 10(-6) mol/L with detection limit of 6.63 × 10(-8) mol/L and limit of quantification of 2.21 × 10(-7) mol/L. The method was proposed for the determination of metformin hydrochloride in dosage forms and urine.
authors.forename: Ali K
authors.initials: AK
authors.lastname: Attia
authors.forename: Waheed M
authors.initials: WM
authors.lastname: Salem
authors.forename: A Mohamed
authors.initials: AM
authors.lastname: Mona