title: Shorter telomeres correlate with an increase in the number of uniparental disomies in patients with chronic lymphocytic leukemia.
abstract: This study investigated the correlation of the extent of chromosomal aberrations including uniparental disomies (UPDs) by SNP-chip analysis and FISH to telomere length in 46 patients with CLL. CLL harboring high risk aberrations, i.e. deletions of 11q22-23 or 17p13, had significantly shorter telomeres (higher ΔTL) compared to patients with CLL without such abnormalities. Patients with high chromosomal aberration rates had a worse overall survival compared to cases with lower aberration rates. Interestingly, however, an increase was found in the number of UPDs with shorter telomeres. These findings support the idea that telomeres in CLL cells play a role in the overall chromosome stability and could be involved in the occurrence of UPDs.
authors.affiliation: a Department of Haematology , Medical Faculty, University of Duisburg-Essen , Essen , Germany .|b Institute of Cell Biology (Cancer Research), Medical Faculty , University of Duisburg-Essen , Essen , Germany .
authors.forename: Ludger
authors.initials: L
authors.lastname: Sellmann
authors.affiliation: b Institute of Cell Biology (Cancer Research), Medical Faculty , University of Duisburg-Essen , Essen , Germany .
authors.forename: Rene
authors.initials: R
authors.lastname: Scholtysik
authors.affiliation: c Experimental Haematology, Department of Clinical Research , University Bern , Switzerland , and.
authors.forename: Dirk
authors.initials: D
authors.lastname: de Beer
authors.affiliation: a Department of Haematology , Medical Faculty, University of Duisburg-Essen , Essen , Germany .
authors.forename: Lewin
authors.initials: L
authors.lastname: Eisele
authors.affiliation: b Institute of Cell Biology (Cancer Research), Medical Faculty , University of Duisburg-Essen , Essen , Germany .
authors.forename: Ludger
authors.initials: L
authors.lastname: Klein-Hitpass
authors.affiliation: a Department of Haematology , Medical Faculty, University of Duisburg-Essen , Essen , Germany .
authors.forename: Holger
authors.initials: H
authors.lastname: Nückel
authors.affiliation: a Department of Haematology , Medical Faculty, University of Duisburg-Essen , Essen , Germany .
authors.forename: Ulrich
authors.initials: U
authors.lastname: Dührsen
authors.affiliation: a Department of Haematology , Medical Faculty, University of Duisburg-Essen , Essen , Germany .
authors.forename: Jan
authors.initials: J
authors.lastname: Dürig
authors.affiliation: a Department of Haematology , Medical Faculty, University of Duisburg-Essen , Essen , Germany .
authors.forename: Alexander
authors.initials: A
authors.lastname: Röth
authors.affiliation: c Experimental Haematology, Department of Clinical Research , University Bern , Switzerland , and.|d Department of Haematology , University Hospital , Bern , Switzerland.
authors.forename: Gabriela M
authors.initials: GM
authors.lastname: Baerlocher
mesh_terms: D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000401:mortality; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012189:Retrospective Studies; D016615:Telomere / Q000235:genetics; D059506:Telomere Shortening; D024182:Uniparental Disomy
keywords: CLL; SNP chips; UPD; telomere length