title: Macular function measured by binocular mfERG and compared with macular structure in healthy children.
abstract: OBJECTIVE
  To create normative data in children from binocular multifocal ERG (mfERG) recordings and compare results with the macular thickness.
  
  
  METHODS
  Forty-nine 5- to 15-year-old healthy, full-term children were examined with Espion Multifocal System, using DTL electrodes. The stimulus matrix consisted of 37 hexagonal elements. Amplitudes, implicit times and response densities (presented in three rings) of the first-order component P1 were analyzed. Measurements of macular thickness were performed with spectral-domain Cirrus OCT.
  
  
  RESULTS
  There were no significant differences between right and left eyes regarding mfERG recordings. Median P1 implicit times of Rings 1-3 of the 46 right eyes were 30.0, 30.0 and 30.8 ms and response densities 20.5, 10.9 and 7.6 nV/deg(2), respectively. Implicit time was longer in boys than in girls (p = 0.009, 0.039, 0.005 in Rings 1-3) and was correlated with age (r s = 0.417, 0.316, 0.274 in Rings 1-3). Implicit time in Ring 1 correlated significantly with the inner circle of the OCT measurements (p = 0.014).
  
  
  CONCLUSIONS
  Binocular mfERG with DTL electrodes is a reliable test of the central macular function in children and correlates with macular structure. As previously not shown, there was a significant difference in implicit time between boys and girls.
authors.affiliation: Department of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden.
authors.forename: Anna E C
authors.initials: AE
authors.lastname: Molnar
authors.affiliation: Department of Ophthalmology, Lund University, Lund, Sweden.
authors.forename: Sten O L
authors.initials: SO
authors.lastname: Andreasson
authors.affiliation: Department of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden.
authors.forename: Eva K B
authors.initials: EK
authors.lastname: Larsson
authors.affiliation: Department of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden.
authors.forename: Hanna M
authors.initials: HM
authors.lastname: Åkerblom
authors.affiliation: Department of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden. gerd.holmstrom@neuro.uu.se.
authors.forename: Gerd E
authors.initials: GE
authors.lastname: Holmström
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004596:Electroretinography / Q000379:methods; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008266:Macula Lutea / Q000502:physiology*; D008297:Male; D012016:Reference Values; D015348:Vision, Binocular / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology
keywords: Binocular; DTL electrodes; Healthy children; Multifocal electroretinogram; Optic coherence tomography