title: Telephone-administered psychotherapy in combination with antidepressant medication for the acute treatment of major depressive disorder.
abstract: BACKGROUND
  Telephone-administered psychotherapies (T-P) provided as an adjunct to antidepressant medication may improve response rates in major depressive disorder (MDD). The goal of this study was to compare telephone-administered social rhythm therapy (T-SRT) and telephone-administered intensive clinical management (T-ICM) as adjuncts to antidepressant medication for MDD. A secondary goal was to compare T-P with Treatment as Usual (TAU) as adjunctive treatment to medication for MDD.
  
  
  METHODS
  221 adult out-patients with MDD, currently depressed, were randomly assigned to 8 sessions of weekly T-SRT (n=110) or T-ICM (n=111), administered as an adjunct to agomelatine. Both psychotherapies were administered entirely by telephone, by trained psychologists who were blind to other aspects of treatment. The 221 patients were a posteriori matched with 221 depressed outpatients receiving TAU (controls). The primary outcome measure was the percentage of responders at 8 weeks post-treatment.
  
  
  RESULTS
  No significant differences were found between T-SRT and T-ICM. But T-P was associated with higher response rates (65.4% vs 54.8%, p=0.02) and a trend toward higher remission rates (33.2% vs 25.1%; p=0.06) compared to TAU.
  
  
  CONCLUSIONS
  Short term study.
  
  
  CONCLUSIONS
  This study is the first assessing the short-term effects of an add-on, brief, telephone-administered psychotherapy in depressed patients treated with antidepressant medication. Eight sessions of weekly telephone-delivered psychotherapy as an adjunct to antidepressant medication resulted in improved response rates relative to medication alone.
authors.affiliation: INSERM UMR 1178, Paris XI University, Department of Psychiatry, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, 94230 Le Kremlin Bicêtre, France. Electronic address: emmanuelle.corruble@bct.ap-hop-paris.fr.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Corruble
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Holly A
authors.initials: HA
authors.lastname: Swartz
authors.affiliation: Department of Psychiatry, Centre Hospitalier de Martigues, 13698 Martigues Cedex, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Bottai
authors.affiliation: Lille University, SCA-lab UMR CNRS 9193, Department of Psychiatry, CHRU de Lille, Lille, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vaiva
authors.affiliation: Paris Descartes University, Centre Hospitalier Sainte-Anne, Paris, France.
authors.forename: Frank
authors.initials: F
authors.lastname: Bayle
authors.affiliation: CHU Clermont-Ferrand, BP 69, Clermont-Ferrand cedex 01, France; Clermont University, Auvergne University, France.
authors.forename: Pierre-Michel
authors.initials: PM
authors.lastname: Llorca
authors.affiliation: Montpellier University, INSERM U 1061, Department of Emergency Psychiatry, CHU Montpellier, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtet
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Ellen
authors.initials: E
authors.lastname: Frank
authors.affiliation: INSERM UMR 894, Paris Descartes University, Centre Hospitalier Sainte-Anne, 100 rue de la Santé, 75015 Paris, France.
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011613:Psychotherapy / Q000379:methods*; D011614:Psychotherapy, Brief / Q000379:methods; D013689:Telephone
chemical_list: D000928:Antidepressive Agents
keywords: Adjunctive; Antidepressant; Interpersonal and social rhythm therapy; Major depressive disorder; Major depressive episode; Psychotherapy; Social rhythm therapy; Telephone intervention