title: Urine BLCA-4 exerts potential role in detecting patients with bladder cancers: a pooled analysis of individual studies.
abstract: Epidemiological studies have explored the diagnostic effect of urine BLCA-4 in bladder cancer. However, the results remain controversial. Therefore, we conducted this pooled analyses to determine the overall accuracy of urine BLCA-4 in bladder cancer. A comprehensive electronic and hand search was conducted for related literatures though several databases. QUADAS-2 was used to assess the quality of each included studies. Diagnostic parameters were calculated using Meta-Disc (version 1.4) and Stata (version 12.0) software. Nine published articles with 1,119 subjects were included. The summary estimates were: sensitivity 0.93 (95 % confidence interval [CI] = 0.90-0.95), specificity 0.97 (95% CI, 0.95-0.98), positive likelihood ratio 48.16 (95% CI, 11.77-197.01), negative likelihood ratio 0.08 (95% CI, 0.06-0.11), diagnostic odds ratio 534.03 (95% CI, 150.15-1899.31), and the AUC was 0.9607. In conclusion, urine BLCA-4 is a promising marker in diagnosing bladder cancer.
authors.affiliation: Department of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Qiliang
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Department of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Pharmaceutical Department, the Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Gong
authors.affiliation: Department of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Kuo
authors.initials: K
authors.lastname: Yang
authors.affiliation: Department of Radiotherapy, the Second Hospital of Tianjin Medical University, Tianjin,China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: Library of Tianjin Medical University, Tianjin Medical University, Tianjin, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Yuanjie
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Tianjin Institute of Infectious Disease, the Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D014408:Biomarkers, Tumor / Q000652:urine*; D015331:Cohort Studies; D006801:Humans; D009687:Nuclear Proteins / Q000652:urine*; D011379:Prognosis; D012372:ROC Curve; D012044:Regression Analysis; D012984:Software; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000652:urine*; D009363:Neoplasm Proteins
chemical_list: D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; C413062:BLCA-4 protein, human; D009363:Neoplasm Proteins
keywords: BLCA-4; bladder cancer; diagnosis; diagnostic biomarker; meta-analysis