title: A preliminary analysis of the reduction of chemotherapy waste in the treatment of cancer with centralization of drug preparation.
abstract: BACKGROUND
  chemotherapy is essential to treat most types of cancer. Often, there is chemotherapy waste in the preparation of drugs prescribed to the patient. Leftover doses result in toxic waste production.
  
  
  OBJECTIVE
  the aim of the study was to analyze chemotherapy waste reduction at a centralized drug preparation unit.
  
  
  METHODS
  the study was cross-sectional, observational and descriptive, conducted between 2010 and 2012. The data were obtained from chemotherapy prescriptions made by oncologists linked to a health insurance plan in Curitiba, capital of the state of Paraná, in southern Brazil. Dose and the cost of chemotherapy waste were calculated in each application, considering the dose prescribed by the doctor and the drug dosages available for sale. The variables were then calculated considering a hypothetical centralized drug preparation unit.
  
  
  RESULTS
  there were 176 patients with a cancer diagnosis, 106 of which underwent treatment with intravenous chemotherapy. There were 1,284 applications for intravenous anticancer medications. There was a total of 63,824mg in chemotherapy waste, the cost of which was BRL 448,397.00. The average cost of chemotherapy waste per patient was BRL 4,607.00. In the centralized model, there was 971.80mg of chemotherapy waste, costing BRL 13,991.64. The average cost of chemotherapy waste per patient was BRL 132.00.
  
  
  CONCLUSIONS
  the use of centralized drug preparation units may be a strategy to reduce chemotherapy waste.
authors.affiliation: Universidade Federal do Paraná, Curitiba, PR, BR.
authors.forename: Adriano
authors.initials: A
authors.lastname: Hyeda
authors.affiliation: ISAE, Fundação Getúlio Vargas, Curitiba, PR, BR.
authors.forename: Elide Sbardellotto Mariano da
authors.initials: ES
authors.lastname: Costa
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000191:economics; D001938:Brazil; D002497:Centralized Hospital Services / Q000379:methods; D017046:Cost Savings; D003430:Cross-Sectional Studies; D004339:Drug Compounding / Q000191:economics / Q000379:methods*; D016527:Drug Costs; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents