title: Rosai-Dorfman Disease of Rare Isolated Spinal Involvement: Report of 4 Cases and Literature Review.
abstract: BACKGROUND
  Rosai-Dorfman disease (RDD) is a rare histioproliferative disorder that only occasionally involves the central nervous system (CNS).
  
  
  METHODS
  The diagnosis and treatment of 4 patients with isolated spinal RDD are discussed. All 4 patients were treated by total or subtotal surgical resection and none of them experienced recurrence. Histopathologic examination showed a characteristic emperipolesis, and the lymphocytes were engulfed in the S-100-protein-positive histiocytes with no expression of CD1a.
  
  
  CONCLUSIONS
  Preoperative diagnosis of spinal RDD is still challenging because the lesion is usually a dura-based lesion that mimics a meningioma. Surgical resection is an effective treatment, and radiotherapy, steroid therapy, and chemotherapy have not shown reliable therapeutic efficiency.
authors.affiliation: Department of Neurosurgery, San Bo Brain Hospital, Capital Medical University, Beijing, China.
authors.forename: Bo Yuan
authors.initials: BY
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: zhanghua3579@hotmail.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: College of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
authors.forename: Wen Jing
authors.initials: WJ
authors.lastname: Zong
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: 525111209@qq.com.
authors.forename: Yan Hui
authors.initials: YH
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D002574:Cervical Vertebrae; D003937:Diagnosis, Differential; D004388:Dura Mater; D005260:Female; D006644:Histiocytes / Q000737:chemistry; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis; D008579:Meningioma / Q000175:diagnosis; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods; D009418:S100 Proteins / Q000032:analysis; D013116:Spinal Cord / Q000473:pathology* / Q000601:surgery*; D013904:Thoracic Vertebrae; D016896:Treatment Outcome
chemical_list: D009418:S100 Proteins
keywords: Isolated spinal involvement; Rosai-Dorfman disease