title: Broca's region and Visual Word Form Area activation differ during a predictive Stroop task.
abstract: Competing theories attempt to explain the function of Broca's area in single word processing. Studies have found the region to be more active during processing of pseudo words than real words and during infrequent words relative to frequent words and during Stroop (incongruent) color words compared to Non-Stroop (congruent) words. Two related theories explain these findings as reflecting either "cognitive control" processing in the face of conflicting input or a linguistic prediction error signal, based on a predictive coding approach. The latter implies that processing cost refers to violations of expectations based on the statistical distributions of input. In this fMRI experiment we attempted to disentangle single word processing cost originating from cognitive conflict and that stemming from predictive expectation violation. Participants (N = 49) responded to whether the words "GREEN" or "RED" were displayed in green or red (incongruent vs congruent colors). One of the colors, however, was presented three times as often as the other, making it possible to study both congruency and frequency effects independently. Auditory stimuli saying "GREEN" or "RED" had the same distribution, making it possible to study frequency effects across modalities. We found significant behavioral effects of both incongruency and frequency. A significant effect (p < .05 FWE) of incongruency was found in Broca's region, but no effect of frequency was observed and no interaction. Conjoined effects of incongruency and frequency were found in parietal regions as well as in the Visual Word Form Area (VWFA). No interaction between perceptual modality and frequency was found in VWFA suggesting that the region is not strictly visual. These findings speak against a strong version of the prediction error processing hypothesis in Broca's region. They support the idea that prediction error processes in the intermediate timeframe are allocated to more posterior parts of the brain.
authors.affiliation: Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus C, Denmark; Center for Semiotics, Aarhus University, Denmark. Electronic address: mikkel@cfin.dk.
authors.forename: Mikkel
authors.initials: M
authors.lastname: Wallentin
authors.affiliation: Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, 8000 Aarhus C, Denmark; Department of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark.
authors.forename: Claus Højbjerg
authors.initials: CH
authors.lastname: Gravholt
authors.affiliation: Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, 8000 Aarhus C, Denmark; Department of Clinical Genetics, Aarhus University Hospital, 8200 Aarhus N, Denmark.
authors.forename: Anne
authors.initials: A
authors.lastname: Skakkebæk
mesh_terms: D000328:Adult; D001931:Brain Mapping; D065711:Broca Area / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008037:Linguistics / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology*; D055815:Young Adult
keywords: Broca's region; Predictive coding; Stroop; Visual word form area