title: Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy.
abstract: Cancer remains an important cause of mortality nowadays and, therefore, new therapeutic approaches are still needed. Rosemary (Rosmarinus officinalis L.) has been reported to possess antitumor activities both in vitro and in animal studies. Some of these activities were attributed to its major components, such as carnosic acid, carnosol, ursolic acid, and rosmarinic acid. Initially, the antitumor effects of rosemary were attributed to its antioxidant activity. However, in recent years, a lack of correlation between antioxidant and antitumor effects exerted by rosemary was reported, and different molecular mechanisms were related to its tumor inhibitory properties. Moreover, supported by the U.S. Food and Drug Administration and the European Food and Safety Authority, specific compositions of rosemary extract were demonstrated to be safe for human health and used as antioxidant additive in foods, suggesting the potential easy application of this agent as a complementary approach in cancer therapy. In this review, we aim to summarize the reported anticancer effects of rosemary, the demonstrated molecular mechanisms related to these effects and the interactions between rosemary and currently used anticancer agents. The possibility of using rosemary extract as a complementary agent in cancer therapy in comparison with its isolated components is discussed.
authors.affiliation: a Unit of Molecular Oncology and Nutritional Genomics of Cancer, Madrid Institute for Advanced Studies on Food (IMDEA Food), Campus of International Excellence, (CEI) UAM+CSIC , Madrid , Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: González-Vallinas
authors.affiliation: b Unit of Food Products for Health , Madrid Institute for Advanced Studies on Food (IMDEA Food) and Department of Production and Characterization of Novel Foods, Institute of Food Science Research , Campus of International Excellence, (CEI) UAM+CSIC, Madrid , Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Reglero
authors.affiliation: a Unit of Molecular Oncology and Nutritional Genomics of Cancer, Madrid Institute for Advanced Studies on Food (IMDEA Food), Campus of International Excellence, (CEI) UAM+CSIC , Madrid , Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Ramírez de Molina
mesh_terms: D045784:Abietanes / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D000975:Antioxidants; D001943:Breast Neoplasms / Q000188:drug therapy; D002934:Cinnamates / Q000627:therapeutic use; D053630:Depsides / Q000627:therapeutic use; D004347:Drug Interactions; D005060:Europe; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D027542:Rosmarinus / Q000737:chemistry*; D014315:Triterpenes / Q000627:therapeutic use; D014481:United States; D014486:United States Food and Drug Administration; D000097123:Rosmarinic Acid; D000097245:Ursolic Acid
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D002934:Cinnamates; D053630:Depsides; D010936:Plant Extracts; D014315:Triterpenes; D000097123:Rosmarinic Acid; D000097245:Ursolic Acid; C068623:carnosol; C018381:salvin