title: Surgical management of lateral skull base defects.
abstract: We sought to analyze key factors that influence the management of lateral skull base defects and implement an algorithm to improve outcomes of reconstruction.
  
  
  
  Retrospective chart review.
  
  
  
  Single tertiary academic referral center.
  
  
  
  Adults who underwent temporal bone resection were included. Variables included tumor characteristics, ablative procedure, reconstructive method, and wound complications.
  
  
  
  Seventy-one patients were studied. Lateral temporal bone resection was performed in 55 patients (77%), subtotal temporal bone resection in 14 (20%), and total petrosectomy in two (3%). Primary closure was achieved in 46 patients (35%), with rotational muscle flaps in 21 (46%). The pectoralis major myocutaneous flap (PMMF) was used in nine patients (13%) without major complications. Single-stage free tissue transfer was undertaken in 10 patients (14%) with no flap failures. Primary closure was achieved in 16 of 32 of previously untreated cases (50%) compared to nine of 39 cases of previously treated disease (23%) (P = 0.03). Pedicled or free flaps were used in 18 of 39 cases of previously treated disease (46%) compared to three of 32 previously untreated cases (9%) (P < 0.001). Pedicled or free flaps were used in 13 of 22 cases (59%) in which partial or total auriculectomy was performed, whereas primary closure was achieved in 39 of 49 cases (80%) in which the pinna was preserved (P < 0.001).
  
  
  
  Advanced tumors that require adjuvant therapy, revision cases for recurrent disease, and cases involving auriculectomy warrant free flap or PMMF reconstruction, with the latter preferred in poor free flap candidates.
  
  
  
  4. Laryngoscope, 126:1911-1917, 2016.
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Neil S
authors.initials: NS
authors.lastname: Patel
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Mara C
authors.initials: MC
authors.lastname: Modest
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Tyler D
authors.initials: TD
authors.lastname: Brobst
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Carlson
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Price
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Moore
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Janus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000379:methods; D012189:Retrospective Studies; D019291:Skull Base / Q000601:surgery*; D019292:Skull Base Neoplasms / Q000601:surgery*; D055815:Young Adult
keywords: Skull base reconstruction; auriculectomy; free flap; pedicled flap; temporal bone resection