title: Computational analyses of the length and compositional variations of the FNBP4 gene across 10 different species.
abstract: Formin binding protein 4 (FNBP4) interacts with formins and other proteins via its WW domains. Previously, we reported the structural and phylogenetic clustering of FNBP4 across a wide range of organisms from different taxonomic groups along with characterizing its plant variant (Arabidopsis thaliana F4JC80). Recently, the FNBP4 gene is reported to be associated with a congenital disorder Microphthalmia with Limb Anomalies. Except these reports, FNBP4 is mostly uncharacterized, especially the FNBP4 gene. In this context, we have attempted to characterize the FNBP4 gene in terms of its length and compositional variations across 10 different organisms from different taxonomic groups. Our findings highlight that the length of the FNBP4 gene varies greatly among different species. Introns, UTRs and the entire gene were AT rich while CDS and mRNAs were GC rich. The RSCU values were also different for the different organisms indicating a possible impact on translational efficiency of this protein. Comparative analyses highlight gene element and base proportions related characteristics specific to highly expression regulated genes like FNBP4.
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia, WB 741235, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Das
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia, WB 741235, India.
authors.forename: Simanti
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia, WB 741235, India.
authors.forename: Sanchari
authors.initials: S
authors.lastname: Bhattacharjee
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia, WB 741235, India. Electronic address: angshumanb@gmail.com.
authors.forename: Angshuman
authors.initials: A
authors.lastname: Bagchi
authors.affiliation: Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia, WB 741235, India. Electronic address: rdgadg@gmail.com.
authors.forename: Rakhi
authors.initials: R
authors.lastname: Dasgupta
mesh_terms: D000818:Animals; D001482:Base Composition; D002352:Carrier Proteins / Q000235:genetics*; D019295:Computational Biology / Q000379:methods*; D017124:Conserved Sequence; D019143:Evolution, Molecular; D014644:Genetic Variation; D006801:Humans; D010944:Plants / Q000235:genetics
chemical_list: D002352:Carrier Proteins
keywords: Codon; Exons; Formin binding protein 4; Gene; Introns; RSCU