title: Cost-Utility Analysis of Cancer Prevention, Treatment, and Control: A Systematic Review.
abstract: BACKGROUND
  Substantial innovation related to cancer prevention and treatment has occurred in recent decades. However, these innovations have often come at a significant cost. Cost-utility analysis provides a useful framework to assess if the benefits from innovation are worth the additional cost. This systematic review on published cost-utility analyses related to cancer care is from 1988 through 2013. Analyses were conducted in 2013-2015.
  
  
  METHODS
  This review analyzed data from the Tufts Medical Center Cost-Effectiveness Analysis Registry (www.cearegistry.org), a comprehensive registry with detailed information on 4,339 original cost-utility analyses published in the peer-reviewed medical and economic literature through 2013.
  
  
  RESULTS
  There were 721 cancer-related cost-utility analyses published from 1998 through 2013, with roughly 12% of studies focused on primary prevention and 17% focused on secondary prevention. The most often studied cancers were breast cancer (29%); colorectal cancer (11%); and prostate cancer (8%). The median reported incremental cost-effectiveness ratios (in 2014 U.S. dollars) were $25,000 for breast cancer, $24,000 for colorectal cancer, and $34,000 for prostate cancer.
  
  
  CONCLUSIONS
  The current evidence indicates that there are many interventions that are cost effective across cancer sites and levels of prevention. However, the results highlight the relatively small number of cancer cost-utility analyses devoted to primary prevention compared with secondary or tertiary prevention.
authors.affiliation: Center for the Evaluation of Value and Risk in Health, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts; Department of Health Policy and Management, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Aaron N
authors.initials: AN
authors.lastname: Winn
authors.affiliation: Division of Cancer Prevention and Control, CDC, Atlanta, Georgia.
authors.forename: Donatus U
authors.initials: DU
authors.lastname: Ekwueme
authors.affiliation: Division of Cancer Prevention and Control, CDC, Atlanta, Georgia.
authors.forename: Gery P
authors.initials: GP
authors.lastname: Guy
authors.affiliation: Center for the Evaluation of Value and Risk in Health, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts. Electronic address: pneumann@tuftsmedicalcenter.org.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Neumann
mesh_terms: D001943:Breast Neoplasms / Q000517:prevention & control / Q000628:therapy; D015179:Colorectal Neoplasms / Q000517:prevention & control / Q000628:therapy; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000517:prevention & control* / Q000628:therapy*; D011314:Preventive Health Services / Q000191:economics* / Q000458:organization & administration; D011471:Prostatic Neoplasms / Q000517:prevention & control / Q000628:therapy