title: FKBP5 risk alleles and the development of intrusive memories.
abstract: Intrusive memories are unwanted recollections that maintain distress and are central to numerous psychological disorders, including posttraumatic stress disorder (PTSD). Convergent evidence suggests that glucocorticoid increases enhance the strength of emotional memories. The FKBP5 polymorphism modulates glucocorticoid receptor sensitivity, and has been shown to increase risk for PTSD. Healthy high and low risk FKBP5 allele carriers (N=46) underwent a cold pressor task, and then viewed negative and neutral images. Two days later participants were given a surprise recall test and measure of intrusive memories of the images. Following the cold pressor task, high-risk allele participants had a higher cortisol response than low-risk participants. High-risk carriers also reported more intrusive memories of the negative and neutral images than low-risk carriers. These findings point to the minor alleles of the FKBP5 polymorphism being a risk factor for development of intrusive memories, possibly as a result of impaired glucocorticoid receptor sensitivity. This may explain one mechanism for FKBP5 being a risk factor for PTSD following traumatic events.
authors.affiliation: School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Jessica
authors.initials: J
authors.lastname: Cheung
authors.affiliation: School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: r.bryant@unsw.edu.au.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Bryant
mesh_terms: D000328:Adult; D000483:Alleles; D004644:Emotions / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D008016:Life Change Events; D008297:Male; D008568:Memory / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D012463:Saliva / Q000737:chemistry; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics*; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D000099159:Tacrolimus Binding Protein 5
chemical_list: D006854:Hydrocortisone; D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5
keywords: Emotional memory; FKBP5; Glucocorticoid; Intrusive memories