title: Silyl Nitronate Cycloadditions Catalyzed by Cu(II)-Bisoxazoline.
abstract: Cu(OTf)2 and chiral BOX ligand-catalyzed 1,3-dipolar cycloadditions of triisopropylsilyl nitronates with α,β-unsaturated carboximides produced chiral isoxazolines in high yields, high enantioselectivities, and complete diastereoselectivities. These chiral isoxazoline products were further converted into structurally diversified derivatives, which demonstrated the utility of the new method of constructing isoxazolines. The transition-state structure of cycloaddition was proposed in the light of the relative and absolute configurations of the products.
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Dong
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors.forename: Caiwei
authors.initials: C
authors.lastname: Geng
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Jiao