title: Prophylactic treatment for preeclampsia in high-risk teenage primigravidae with nitric oxide donors: a pilot study.
abstract: OBJECTIVE
  Preeclampsia is associated with significant morbidity and mortality especially in high-risk groups. Impairment of endogenous nitric oxide has been shown to be associated with the disease and prophylactic therapy may ameliorate this condition and improve pregnancy outcome. This study valuated nitric oxide donors prophylactic treatment for preeclampsia in high-risk teenage primigravidae.
  
  
  METHODS
  The study included three hundred primigravidae aged ≤ 20 years with singleton pregnancy. Abdominal pulsed color Doppler ultrasound was done at 24 weeks gestation and pregnancies with uterine artery diastolic notch were randomly allocated to a control group received placebo vaginal tablets and a study group received isosorbid mononitrate 20 mg tablet once daily applied vaginally until delivery.
  
  
  RESULTS
  Incidence of preeclampsia and maternal, fetal, and neonatal outcome in both groups.
  
  
  RESULTS
  The study group had significant lower incidence of preeclampsia, preterm birth, intrauterine growth restriction and of neonatal admission to the intensive care (p < 0.05).
  
  
  CONCLUSIONS
  Nitric oxide donors prophylactic treatment for preeclampsia in high-risk teenage pregnancies decrease the incidence of preeclampsia and improve maternal, fetal, and neonatal outcomes. Further studies on larger sample size are required to confirm these results.
authors.affiliation: a Department of Obstetrics and Gynecology , Banha Faculty of Medicine , Banha , Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdel Razik
authors.affiliation: a Department of Obstetrics and Gynecology , Banha Faculty of Medicine , Banha , Egypt.
authors.forename: Seham
authors.initials: S
authors.lastname: El-Berry
authors.affiliation: a Department of Obstetrics and Gynecology , Banha Faculty of Medicine , Banha , Egypt.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Abosereah
authors.affiliation: a Department of Obstetrics and Gynecology , Banha Faculty of Medicine , Banha , Egypt.
authors.forename: Yehia
authors.initials: Y
authors.lastname: Edris
authors.affiliation: a Department of Obstetrics and Gynecology , Banha Faculty of Medicine , Banha , Egypt.
authors.forename: Amrr
authors.initials: A
authors.lastname: Sharafeldeen
mesh_terms: D000293:Adolescent; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000517:prevention & control; D005865:Gestational Age; D020073:Gravidity; D006801:Humans; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal / Q000706:statistics & numerical data; D020030:Nitric Oxide Donors / Q000627:therapeutic use*; D010865:Pilot Projects; D010919:Placebos; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000517:prevention & control*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011253:Pregnancy in Adolescence; D018566:Pregnancy, High-Risk; D047928:Premature Birth / Q000453:epidemiology / Q000517:prevention & control; D016216:Ultrasonography, Prenatal; D055815:Young Adult
chemical_list: D020030:Nitric Oxide Donors; D010919:Placebos
keywords: Nitric oxide donors; preeclampsia; prophylaxis