title: Review and Updates in Regenerative and Personalized Medicine, Preclinical Animal Models, and Clinical Care in Cardiovascular Medicine.
abstract: The goal of this paper is to provide an updated review for scientists and clinicians on the major areas in cardiovascular medicine published in the Journal. Leading topics in regenerative and personalized medicine are presented along with a critical overview of the field. New standards in large preclinical animal models of pulmonary hypertension and left bundle branch block are highlighted. Finally, clinical care in the areas of atherosclerosis, the aortic valve, platelet biology, and myocarditis is discussed as well as autonomic modulation therapies.
authors.affiliation: Cardiovascular Center, Aalst OLV Clinic, Aalst, Belgium.|Belgium and Department of Advance Biomedical Sciences, University of Naples, Federico II, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Barbato
authors.affiliation: National Institute of Heart Research, Royal Brompton Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Barton
authors.affiliation: Cardiovascular Center, Aalst OLV Clinic, Aalst, Belgium.
authors.forename: Jozef
authors.initials: J
authors.lastname: Bartunek
authors.affiliation: Department of Pathology, University of Vermont, Colchester, VT, USA.
authors.forename: Sally
authors.initials: S
authors.lastname: Huber
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.|IIS-Fundación Jiménez Díaz Hospital, Madrid, Spain.
authors.forename: Borja
authors.initials: B
authors.lastname: Ibanez
authors.affiliation: Johns Hopkins Center for Inherited Disease, Baltimore, MD, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Judge
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Lara-Pezzi
authors.affiliation: Boston Scientific Corporation, St. Paul, MN, USA.
authors.forename: Craig M
authors.initials: CM
authors.lastname: Stolen
authors.affiliation: Cardiovascular Research Center, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Taylor
authors.affiliation: Lillehei Heart Institute, Department of Medicine, University of Minnesota, 4-138 Cancer and Cardiovascular Research Building 2231 6th Street SE, Minneapolis, MN, 55455, USA. jlhall@umn.edu.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Hall
mesh_terms: D000818:Animals; D002309:Cardiology / Q000639:trends*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D004059:Diffusion of Innovation; D004195:Disease Models, Animal; D006801:Humans; D057285:Precision Medicine / Q000639:trends*; D044968:Regenerative Medicine / Q000639:trends*
keywords: Autonomic modulation; Cardiovascular; Electronic health record; Genomics; Heart; Left bundle branch block; Myocarditis; Personalized medicine; Platelets; Preclinical; Pulmonary hypertension; Regenerative medicine; Stem cell