title: New Perspectives for the Rescue of Cognitive Disability in Down Syndrome.
abstract: Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna 40126, Italy.
authors.forename: Renata
authors.identifier: http://orcid.org/0000-0002-1640-0995
authors.initials: R
authors.lastname: Bartesaghi
authors.affiliation: Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118.
authors.forename: Tarik F
authors.identifier: http://orcid.org/0000-0001-6772-3076
authors.initials: TF
authors.lastname: Haydar
authors.affiliation: Unit of Functional and Adaptative Biology, University Paris Diderot, Paris 75013, France.
authors.forename: Jean Maurice
authors.identifier: http://orcid.org/0000-0001-7227-0921
authors.initials: JM
authors.lastname: Delabar
authors.affiliation: Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
authors.forename: Mara
authors.identifier: http://orcid.org/0000-0003-0853-6865
authors.initials: M
authors.lastname: Dierssen
authors.affiliation: Department of Physiology and Pharmacology, University of Cantabria, Santander 39011, Spain, and.
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez-Cué
authors.affiliation: Mother Infant Research Institute, Floating Hospital for Children and Department of Pediatrics, Tufts University School of Medicine, Boston, Massachusetts 02111 dbianchi@tuftsmedicalcenter.org.
authors.forename: Diana W
authors.identifier: http://orcid.org/0000-0001-9270-5267
authors.initials: DW
authors.lastname: Bianchi
mesh_terms: D000818:Animals; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D003072:Cognition Disorders / Q000209:etiology* / Q000628:therapy*; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D006801:Humans; D051379:Mice
keywords: Down syndrome; brain abnormalities; intellectual disability; mouse models; preventive therapies