title: Reactivation of Chagas Disease: Implications for Global Health.
abstract: Reactivation of Chagas Disease (CD) is a global public health issue. Reactivation of disease can affect the management of CD and its clinical outcome, adding pressure to global health systems because it exacerbates symptoms, leading to misdiagnosis and delays in the administration of correct treatments. Concurrent infections complicate the issue of reactivation, because there are various parasites and disease treatment regimens that are able to influence or suppress the immune system of the host, reactivating disease within infected individuals. The effect of delayed symptoms of chronic CD and the potential for disease reactivation are of great importance to nonendemic regions of the world, where knowledge about CD is lacking and the potential for vectorial transmission is not known.
authors.affiliation: School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia. Electronic address: c.perez@murdoch.edu.au.
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Perez
authors.affiliation: School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia; Freshwater Fish Group and Fish Health Unit, Murdoch University, South Street, Murdoch, WA 6150, Australia.
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Lymbery
authors.affiliation: School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia.
authors.forename: R C Andrew
authors.initials: RCA
authors.lastname: Thompson
mesh_terms: D014355:Chagas Disease / Q000469:parasitology / Q000517:prevention & control* / Q000628:therapy / Q000635:transmission*; D002908:Chronic Disease; D014943:Global Health; D006801:Humans; D014349:Trypanosoma cruzi / Q000502:physiology
keywords: Chagas disease; Trypanosoma cruzi; concurrent infections; indeterminate infection; reactivation