title: Difference Between HPV-Positive and HPV-Negative Non-Oropharyngeal Head and Neck Cancer: Texture Analysis Features on CT.
abstract: OBJECTIVE
  To identify the specific texture parameter that shows significant differences between human papillomavirus (HPV)-positive (HPV) and HPV-negative (HPV) non-oropharyngeal carcinoma (non-OPC) using texture analysis.
  
  
  METHODS
  Forty-six patients of non-OPC patients (oral cavity, larynx, and hypopharynx) with known HPV status, who underwent contrast-enhanced computed tomography for initial staging, were retrospectively reviewed. Segmentations of the primary lesion were manually performed, and an in-house developed texture analysis program extracted 42 texture features from each segmented volume. A t test was used to evaluate differences between HPV and HPV non-OPCs (P < 0.05).
  
  
  RESULTS
  Sixteen texture parameters, including 5 histogram features (P ≤ 0.03), 3 gray-level co-occurrence matrix features (P ≤ 0.02), 1 gray-level run-length feature (P = 0.009), 2 gray-level gradient matrix features (P ≤ 0.02), and 5 Law features (P ≤ 0.04), showed significant differences.
  
  
  CONCLUSIONS
  Texture analysis demonstrated significant differences between HPV and HPV non-OPCs on computed tomography images, which may have a potential to prove morphologic feature differences among HPV-related tumors.
authors.affiliation: From the *Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA; †Department of Radiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi; and ‡Department of Radiology, Nihon University School of Dentistry at Matsudo, Chiba, Japan; and §Departments of Radiation Oncology and ∥Otolaryngology-Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, Boston, MA.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Fujita
authors.forename: Karen
authors.initials: K
authors.lastname: Buch
authors.forename: Baojun
authors.initials: B
authors.lastname: Li
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kawashima
authors.forename: Muhammad M
authors.initials: MM
authors.lastname: Qureshi
authors.forename: Osamu
authors.initials: O
authors.lastname: Sakai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications* / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media