title: Hematolymphoid lesions of the sinonasal tract.
abstract: Various hematolymphoid lesions involve the sinonasal tract, including aggressive B, T, and NK-cell neoplasms; myeloid sarcoma; low-grade lymphomas; indolent T-lymphoblastic proliferations; and Rosai-Dorfman disease. Differentiating aggressive lymphomas from non-hematopoietic neoplasms such as poorly differentiated squamous cell carcinoma, olfactory neuroblastoma, or sinonasal undifferentiated carcinoma may pose diagnostic challenges. In addition, the necrosis, vascular damage, and inflammatory infiltrates that are associated with some hematolymphoid disorders can result in misdiagnosis as infectious, autoimmune, or inflammatory conditions. Here, we review hematolymphoid disorders involving the sinonasal tract including their key clinical and histopathologic features.
authors.affiliation: Department of Pathology, The Johns Hopkins Medical Institutions, Weinberg 2242, 401 N Broadway, Baltimore, Maryland 21231-2410.
authors.forename: Genevieve M
authors.initials: GM
authors.lastname: Crane
authors.affiliation: Department of Pathology, The Johns Hopkins Medical Institutions, Weinberg 2242, 401 N Broadway, Baltimore, Maryland 21231-2410. Electronic address: aduffie1@jhmi.edu.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Duffield
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D015618:Histiocytosis, Sinus / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D008223:Lymphoma / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D009296:Nasal Cavity / Q000737:chemistry / Q000473:pathology*; D009669:Nose Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor
keywords: Adult T-cell leukemia/lymphoma; Diffuse large B-cell lymphoma; Extranodal NK/T-cell lymphoma; Rosai–Dorfman disease; Sinonasal tract