title: Antioxidative and immunological activities of ophiopogon polysaccharide liposome from the root of Ophiopogon japonicus.
abstract: The antioxidative and immunoregulatory activities of ophiopogon polysaccharide liposome (OPL) were investigated. The results demonstrated that the radical-scavenging activity increased along with the increasing of OPL concentrations, and the scavenging capability of OPL was slightly stronger than ophiopogon polysaccharide (OP) in vitro. In vivo, OPL at high and medium doses could significantly improve the levels of SOD and GSH-Px, and decrease the levels of MPO, XOD and MDA compared with OP. In addition, OPL could not only significantly enhance the splenocyte proliferation and the proportion of CD4(+) and CD8(+) T cells, but also improve the levels of cytokines, antigen-specific antibody titers and immune organ index in the mice immunized with OVA compared with OP. These results indicated that the antioxidative and immunoregulatory activities of OP were significantly enhanced after encapsulated with liposome. Therefore, OPL would be expected to exploit into a new-type of functional food as both medicine and food.
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Medicinal Engineering Department of Henan University of Animal Husbandry and Economy, Zhengzhou, Henan 450011, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Ma
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.affiliation: Wuhan Huisheng Biotechnology Group, Wuhan, Hubei 430042, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China. Electronic address: sxpxbnl@163.com.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Song
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000097:blood; D017665:Hydroxyl Radical / Q000737:chemistry; D007074:Immunoglobulin G / Q000097:blood; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D008081:Liposomes; D008813:Mice, Inbred ICR; D031441:Ophiopogon; D010047:Ovalbumin / Q000276:immunology; D010088:Oxidoreductases / Q000097:blood; D010851:Picrates / Q000737:chemistry; D018517:Plant Roots; D011134:Polysaccharides / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D013154:Spleen / Q000166:cytology
chemical_list: D000941:Antigens; D000975:Antioxidants; D001713:Biphenyl Compounds; D016207:Cytokines; D007074:Immunoglobulin G; D007155:Immunologic Factors; D008081:Liposomes; D010851:Picrates; D011134:Polysaccharides; D017665:Hydroxyl Radical; D010047:Ovalbumin; C004931:1,1-diphenyl-2-picrylhydrazyl; D010088:Oxidoreductases
keywords: Antioxidative activity; Immunoregulatory activity; Ophiopogon polysaccharide liposome