title: Endovascular Perforation Murine Model of Subarachnoid Hemorrhage.
abstract: Subarachnoid hemorrhage (SAH) is a subtype of stroke with disastrous outcomes of high disability and mortality. A variety of endeavors have been developed to explore a SAH animal model for investigation of the disease. Among these models, the endovascular perforation SAH model was considered to be the most simulative to the clinical human SAH because it reproduces several pathophysiology procedures and presents some of the most important post-hemorrhage features. An applicable SAH animal model should have the characteristics of low mortality rate, limited surgical manipulation, and adaptation to many species, which permits reproducibility and standardization. An intensive discussion of how to improve the techniques and refine the procedure has taken place in the last decade. This report describes our experiences with a murine model of SAH. We aim to standardize and optimize the procedures to establish a relatively stable animal model for SAH research.
authors.affiliation: Department of Neurosurgery, the First Teaching Hospital of Xinjiang Medical University, Urumqi, 830054, Xinjiang Uygur Autonomous Region, China.|Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Guo Jia
authors.initials: GJ
authors.lastname: Du
authors.affiliation: Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Lu
authors.affiliation: Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Zhi Yuan
authors.initials: ZY
authors.lastname: Zheng
authors.affiliation: Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Wai Sang
authors.initials: WS
authors.lastname: Poon
authors.affiliation: Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China. georgewong@surgery.cuhk.edu.hk.
authors.forename: Kwok Chu George
authors.initials: KC
authors.lastname: Wong
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D002343:Carotid Artery, Internal / Q000601:surgery*; D004195:Disease Models, Animal; D057510:Endovascular Procedures / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011677:Punctures / Q000379:methods*; D013345:Subarachnoid Hemorrhage / Q000473:pathology / Q000503:physiopathology*