title: Molecular mechanisms underlying anticancer effects of myricetin.
abstract: Dietary guidelines published in the past two decades have acknowledged the beneficial effects of myricetin, an important and common type of herbal flavonoid, against several human diseases such as inflammation, cardiovascular pathologies, and cancer. An increasing number of studies have shown the beneficial effects of myricetin against different types of cancer by modifying several cancer hallmarks including aberrant cell proliferation, signaling pathways, apoptosis, angiogenesis, and tumor metastasis. Most importantly, myricetin interacts with oncoproteins such as protein kinase B (PKB) (Akt), Fyn, MEK1, and JAK1-STAT3 (Janus kinase-signal transducer and activator of transcription 3), and it attenuates the neoplastic transformation of cancer cells. In addition, myricetin exerts antimitotic effects by targeting the overexpression of cyclin-dependent kinase 1 (CDK1) in liver cancer. Moreover, it also targets the mitochondria and promotes different kinds of cell death in various cancer cells. In the present paper, a critical review of the available literature is presented to identify the molecular targets underlying the anticancer effects of myricetin.
authors.affiliation: Department of Biotechnology, Science Block, Alagappa University, Karaikudi 630 004, Tamil Nadu, India.
authors.forename: Kasi Pandima
authors.initials: KP
authors.lastname: Devi
authors.affiliation: Department of Biotechnology, Science Block, Alagappa University, Karaikudi 630 004, Tamil Nadu, India.
authors.forename: Tamilselvam
authors.initials: T
authors.lastname: Rajavel
authors.affiliation: Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Kent, UK.
authors.forename: Solomon
authors.initials: S
authors.lastname: Habtemariam
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005419:Flavonoids / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D008938:Mitosis / Q000187:drug effects*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015513:Oncogene Proteins / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; D015513:Oncogene Proteins; C040015:myricetin
keywords: Akt; Ap-1; Apoptosis; Cdk1; Erk1 and Erk2; Jak1; Mek1; Metastasis; Myricetin; Stat3