title: Cord Blood 25-hydroxyvitamin D and Fetal Growth in the China-Anhui Birth Cohort Study.
abstract: We determined the association of cord blood 25-hydroxyvitamin D [25(OH)D] with birth weight and the risk of small for gestational age (SGA). As part of the China-Anhui Birth Cohort (C-ABC) study, we measured cord blood levels of 25(OH)D in 1491 neonates in Hefei, China. The data on maternal sociodemographic characteristics, health status, lifestyle, birth outcomes were prospectively collected. Multiple regression models were used to estimate the association of 25(OH)D levels with birth weight and the risk of SGA. Compared with neonates in the lowest decile of cord blood 25(OH)D levels, neonates in four deciles (the fourth, fifth, sixth and seventh deciles) had significantly increased birth weight and decreased risk of SGA. Multiple linear regression models showed that per 10 nmol/L increase in cord blood 25(OH)D, birth weight increased by 61.0 g (95% CI: 31.9, 89.9) at concentrations less than 40 nmol/L, and then decreased by 68.5 g (95% CI: -110.5, -26.6) at concentrations from 40 to 70 nmol/L. This study provides the first epidemiological evidence that there was an inverted U shaped relationship between neonatal vitamin D status and fetal growth, and the risk of SGA reduced at moderate concentration.
authors.affiliation: Department of Maternal, Child &Adolescent Health, Anhui Medical University, Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical University, Hefei, China.|School of Public Health and social work, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Qld, Australia.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhu
authors.affiliation: Department of Maternal, Child &Adolescent Health, Anhui Medical University, Hefei, China.|School of Public Health and social work, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Qld, Australia.
authors.forename: Shi-lu
authors.initials: SL
authors.lastname: Tong
authors.affiliation: School of Public Health and social work, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Qld, Australia.
authors.forename: Wen-biao
authors.initials: WB
authors.lastname: Hu
authors.affiliation: Department of Maternal, Child &Adolescent Health, Anhui Medical University, Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical University, Hefei, China.
authors.forename: Jia-hu
authors.initials: JH
authors.lastname: Hao
authors.affiliation: Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei, China.
authors.forename: Rui-xue
authors.initials: RX
authors.lastname: Tao
authors.affiliation: Department of Maternal, Child &Adolescent Health, Anhui Medical University, Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical University, Hefei, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.affiliation: Shanghai Key Laboratory of Meteorology and Health, Shanghai, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Mou
authors.affiliation: Department of Maternal, Child &Adolescent Health, Anhui Medical University, Hefei, China.
authors.forename: Qi-fan
authors.initials: QF
authors.lastname: Zhou
authors.affiliation: Department of Gynecology and Obstetrics, Hefei Maternal and Child Health Hospital, Hefei, China.
authors.forename: Xiao-min
authors.initials: XM
authors.lastname: Jiang
authors.affiliation: Department of Maternal, Child &Adolescent Health, Anhui Medical University, Hefei, China.|Anhui Provincial Key Laboratory of Population Health &Aristogenics, Anhui Medical University, Hefei, China.
authors.forename: Fang-biao
authors.initials: FB
authors.lastname: Tao
mesh_terms: D001724:Birth Weight / Q000502:physiology*; D002681:China; D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D047109:Fetal Development / Q000502:physiology*; D020567:Fetal Weight / Q000502:physiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D016014:Linear Models; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods / Q000706:statistics & numerical data; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D