title: Exercise and Gene Expression.
abstract: Acute and transient changes in gene transcription following a single exercise bout, if reinforced by repeated exercise stimuli, result in the longer lasting effects on protein expression and function that form the basis of skeletal muscle training adaptations. Changes in skeletal muscle gene expression occur in response to multiple stimuli associated with skeletal muscle contraction, various signaling kinases that respond to these stimuli, and numerous downstream pathways and targets of these kinases. In addition, DNA methylation, histone acetylation and phosphorylation, and micro-RNAs can alter gene expression via epigenetic mechanisms. Contemporary studies rely upon "big omics data," in combination with computational and systems biology, to interrogate, and make sense of, the complex interactions underpinning exercise adaptations. The exciting potential is a greater understanding of the integrative biology of exercise.
authors.affiliation: Department of Physiology, The University of Melbourne, Melbourne, Australia. Electronic address: m.hargreaves@unimelb.edu.au.
authors.forename: Mark
authors.initials: M
authors.lastname: Hargreaves
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D044127:Epigenesis, Genetic; D015444:Exercise / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D049490:Systems Biology; D014158:Transcription, Genetic
keywords: DNA methylation; Exercise; Gene expression; Histone modification