title: [RESEARCH STATUS ON MOLECULAR BASIS OF INTERVERTEBRAL DISC DEGENERATION AND REPAIRING EFFECT OF PLATELET-RICH PLASMA].
abstract: OBJECTIVE
  To review the research status on the molecular basis of intervertebral disc degeneration and the repairing effect of platelet-rich plasma.
  
  
  METHODS
  The related literature about the molecular basis of intervertebral disc degeneration and the repairing effect of platelet-rich plasma was reviewed, analyzed, and summarized.
  
  
  RESULTS
  The molecular basis of intervertebral disc degeneration includes genetic influences, cell senescence, decreased matrix production, increased degradative enzyme production, proinflammatory cytokine expression, apoptosis, and neural ingrowth. Platelet-rich plasma can release a series of growth factors to promote intervertebral disc cells proliferation, differentiation, and extracellular matrix synthesis. It can also inhibit proinflammatory effect and apoptosis.
  
  
  CONCLUSIONS
  Although the prospect of using platelet-rich plasma to repair intervertebral disc degeneration is encouraging, further studies are still needed.
authors.forename: Keke
authors.initials: K
authors.lastname: Gui
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Yu
mesh_terms: D017209:Apoptosis; D002454:Cell Differentiation; D049109:Cell Proliferation; D005109:Extracellular Matrix / Q000378:metabolism; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007403:Intervertebral Disc / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D055959:Intervertebral Disc Degeneration / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D053657:Platelet-Rich Plasma; D011859:Radiography; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D036341:Intercellular Signaling Peptides and Proteins