title: A Biomimetic Core-Shell Platform for Miniaturized 3D Cell and Tissue Engineering.
abstract: This article describes a biomimetic core-shell platformwith a collagen-based core and an alginate hydrogel shell for cell and tissue culture. With this system, chemical and physical properties of extracellular matrix (ECM) in the core microenvironment can be controlled to regulate proliferation and development of cells/tissues under miniaturized three-dimensional (3D) culture.
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA).
authors.forename: Pranay
authors.initials: P
authors.lastname: Agarwal
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA).
authors.forename: Jung Kyu
authors.initials: JK
authors.lastname: Choi
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA). Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210 (USA).
authors.forename: Haishui
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA).
authors.forename: Shuting
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA).
authors.forename: Jenna
authors.initials: J
authors.lastname: Dumbleton
authors.affiliation: Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210 (USA).
authors.forename: Jianrong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA). Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210 (USA).
authors.forename: Xiaoming
authors.initials: X
authors.lastname: He
keywords: 3D culture; biomimetic; core-shell microcapsule; follicle; stem cell