title: The post thrombotic syndrome: Ignore it and it will come back to bite you.
abstract: Post thrombotic syndrome (PTS) is a very common chronic complication of deep venous thrombosis (DVT), as three out of ten patients with lower extremity DVT will develop PTS. The possibility to identify patients at risk is limited. Diagnosis is challenging, because there is no gold standard diagnostic method. Progress in diagnostic options may therefore change future diagnostic strategies. The better understanding of pathophysiologic processes that underlie PTS may stimulate the development of treatment modalities and improve and diversify management options. The quest for adequate preventive strategies and treatment is important because PTS has a detrimental effect on patients' quality of life and is associated with increased healthcare as well as societal costs. The problem of PTS prevention is therefore clearly relevant to patients, doctors as well as policy makers.
authors.affiliation: Cardiovascular Center and Laboratory for Clinical Thrombosis and Hemostasis, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address: Arina.tencate@maastrichtuniversity.nl.
authors.forename: Arina J
authors.initials: AJ
authors.lastname: ten Cate-Hoek
authors.affiliation: Section of Vascular Surgery and the Jobst Vascular Research Laboratory, Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA. Electronic address: henke@umich.edu.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Henke
authors.affiliation: Section of Vascular Surgery and the Jobst Vascular Research Laboratory, Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA. Electronic address: thomasww@med.umich.edu.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Wakefield
mesh_terms: D000818:Animals; D015415:Biomarkers; D003131:Combined Modality Therapy; D019468:Disease Management; D004195:Disease Models, Animal; D006801:Humans; D054070:Postthrombotic Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D011379:Prognosis; D012106:Research
chemical_list: D015415:Biomarkers
keywords: Endothelial dysfunction; Inflammation and coagulation; Non-invasive and invasive management; Pathophysiology; Post-thrombotic syndrome