title: Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model.
abstract: BACKGROUND
  Dementia is the most prevalent neurological disease in aged people. Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD). However, effective therapy for those two diseases is still missing. Resveratrol is a polyphenol produced by plants that have multiple biological functions, such as increased life span and delay in the onset of diseases associated with aging. It is known supplement with resveratrol could exert neuroprotection against multiple injury factors induced neuronal death and degeneration, as well as the cognitive decline of CCH rat model.
  
  
  METHODS
  The morris water maze was used to evaluate the learning and memory, electrophysiological recording was used to detect the synaptic plasticity, the Golgi staining was used to examine the change of dendritic spines, the western blot was used to detect the proteins levels.
  
  
  RESULTS
  We reported that resveratrol pretreatment effectively restore the synaptic plasticity in CCH rats both functional and structural. We also found that the PKA-CREB activation may be a major player in resveratrol-mediated neuroprotection in CCH model.
  
  
  CONCLUSIONS
  Our data provide the mechanistic evidence for the neuroprotective effects of resveratrol in vascular dementia.
authors.affiliation: Department of Neurology, Zhongnan Hospital, Wuhan University, China. Electronic address: lihuagang2003@163.com.
authors.forename: Huagang
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurology, Zhongnan Hospital, Wuhan University, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Rehabilitation, West China Hospital, Sichuang University, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Wang
authors.affiliation: Animal Biosafety Level III Laboratory at the Center for Animal Experiment, Wuhan University, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Rao
authors.affiliation: Department of Gastroenterology, Zhongnan Hospital, Wuhan University, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Chen
mesh_terms: D000818:Animals; D016893:Carotid Stenosis / Q000150:complications; D002560:Cerebrovascular Circulation; D002908:Chronic Disease; D000242:Cyclic AMP / Q000032:analysis; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D015140:Dementia, Vascular / Q000188:drug therapy*; D049229:Dendritic Spines / Q000648:ultrastructure; D018891:Dentate Gyrus / Q000648:ultrastructure; D004789:Enzyme Activation; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D007859:Learning Disabilities / Q000209:etiology / Q000517:prevention & control; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control; D009419:Nerve Tissue Proteins / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D013267:Stilbenes; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D000077185:Resveratrol
keywords: CREB; Dementia; PKA; dendritic spine; resveratrol; synaptic plasticity