title: Serum uric acid and lipid profiles in sporadic Creutzfeldt-Jakob disease.
abstract: OBJECTIVE
  Creutzfeldt-Jakob disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disease affecting the central nervous system. Brain lipid homeostasis and oxidative stress seem to play an important role in the disease pathogenesis. But little was known whether serum lipids and uric acid (a natural antioxidant) levels changed in patients with prion disease.
  
  
  METHODS
  Here we retrospectively reviewed and compared the serum lipids and uric acid levels of 19 probable sporadic CJD patients and 26 healthy control subjects.
  
  
  RESULTS
  We found that the serum uric acid levels in sporadic CJD patients were significantly lower than that in controls (P=0.01). Serum triglycerides, cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and apolipoprotein A1 (ApoA1) were similar in sporadic CJD patients and controls. However, LDL/HDL ratio was lower in sporadic CJD patients (P=0.003).
  
  
  CONCLUSIONS
  The low serum uric acid and LDL/HDL ratio levels in sporadic CJD indicate that dysfunction in the lipid homeostasis and oxidative stress is associated with sporadic prion disease.
authors.affiliation: Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Neurobiology and Beijing Institute for Neuroscience, Capital Medical University, Beijing 100069, China.
authors.forename: Jun-Kui
authors.initials: JK
authors.lastname: Shang
authors.affiliation: Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Ma
authors.affiliation: Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Chang-Shui
authors.initials: CS
authors.lastname: Xu
authors.affiliation: Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Shi
authors.affiliation: Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China. Electronic address: zhangjw9900@126.com.
authors.forename: Jie-Wen
authors.initials: JW
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D007562:Creutzfeldt-Jakob Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D012189:Retrospective Studies; D014527:Uric Acid / Q000097:blood*
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014527:Uric Acid
keywords: Creutzfeldt–Jakob disease; Lipid profiles; Neurodegenerative disease; Serum; Uric acid