title: Influence of Ganoderma lucidum (Curt.: Fr.) P. Karst. on T-cell-mediated immunity in normal and immunosuppressed mice line CBA/Ca.
abstract: The article presents the results of the investigation of the effect of biomass powder of the fungus Ganoderma lucidum on T-cell-mediated immunity in normal and immunosuppressed mice CBA/Ca. Delayed-type hypersensitivity assay was used. Experimental immunodeficiency was established with intraperitoneal injection of the immunosuppressant cyclophosphamide at a single dose of 150 mg/kg on the first day of the experiment. Results of the study show that the administration of biomass powder of Ganoderma lucidum in a dose of 0.5 mg/kg orally for 10 days increases the delayed-type hypersensitivity response in normal mice CBA/Ca. Administration of 0.5 mg/kg of biomass powder of the fungus Ganoderma lucidum for 10 days blocked the development of the T-cell-mediated immunosuppression, induced by administration of cyclophosphamide and restored the delayed-type hypersensitivity response in immunosuppressed mice. Key words: fungus Ganoderma lucidum cyclophosphamide immunodeficiency T-cell-mediated immunity delayed-type hypersensitivity.
authors.forename: Iryna V
authors.initials: IV
authors.lastname: Nizhenkovska
authors.forename: Vitalii T
authors.initials: VT
authors.lastname: Pidchenko
authors.forename: Nina G
authors.initials: NG
authors.lastname: Bychkova
authors.forename: Nina A
authors.initials: NA
authors.lastname: Bisko
authors.forename: Angela Y
authors.initials: AY
authors.lastname: Rodnichenko
authors.forename: Natalya O
authors.initials: NO
authors.lastname: Kozyko
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D016867:Immunocompromised Host; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011208:Powders; D020940:Reishi; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: D011208:Powders; D003520:Cyclophosphamide