title: [Long-term follow up after gastro-endoscopy screening for age ≥45 years male health care population with long-term aspirin used in gastrointestinal mucosal injury].
abstract: OBJECTIVE
  To analyze the characteristics and trends of gastrointestinal mucosal injury for age ≥ 45 years male health care patients during gastro-endoscopic follow-up.
  
  
  METHODS
  Endoscopic reports of age ≥ 45 years male health care patients with long-term aspirin undergoing gastroscopy from October 1999 to April 2014 were retrospectively reviewed. The proportion of different lesions, the distribution at different anatomic sites, and the trends of the number of gastrointestinal mucosal injury in different follow up years were analyzed.
  
  
  RESULTS
  A total of 2 281 endoscopic reports of 259 health care cases aged ≥ 45 years with aspirin used 3 years at least were collected. After the initial gastroscopy screening, there are 239, 103 and 20 cases followed up to the 5(th), 10(th) and 15(th) years. The patients were between 45-91 years of age, their mean age was 67 years. The mean followed-up time was 5 years. In the follow-up process each patient had 8 gastroscopies performed. A total of 4 442 lesions were detected and the mean number was 2 per person for once. The number of gastrointestinal mucosal injuries were different. The number of the gastrointestinal mucosal injury of the 1(st) year was higher than that of initial gastro-endoscopy (P < 0.05). The numbers of the gastrointestinal mucosal injury of the 2(se)-5(th) years during the follow up period were lower than those of initial gastro-endoscopy (all P < 0.05). The numbers of three different lesions of gastrointestinal mucosal injury were different (P < 0.05). The number of erosion was more than petechia and ulcer (both P < 0.05). The Modified Lanza's Score (MDS) were in descending trend during the follow up period. The numbers of gastrointestinal mucosal injury in different anatomic sites were different in the same follow-up years (all P < 0.05).
  
  
  CONCLUSIONS
  The numbers and degree of gastrointestinal mucosal injury for middle aged and aged health care patients with long-term aspirin used during gastro-endoscopic follow-up are in descending trend, however, there is a transient increasing in number of gastrointestinal mucosal injury in the first two years since the aspirin used. The common lesion in gastrointestinal mucosal injury is erosions. Gastric antrum and body are vulnerable anatomical parts during follow-up.
authors.affiliation: Department of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China; Email: wanjun301@126.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Wan
authors.affiliation: Department of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Du
authors.affiliation: Department of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Su
authors.affiliation: Department of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Chen
mesh_terms: D001241:Aspirin; D005500:Follow-Up Studies; D005753:Gastric Mucosa; D005767:Gastrointestinal Diseases; D005773:Gastroscopy; D006801:Humans; D007413:Intestinal Mucosa; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D001241:Aspirin