title: [EFFECTIVENESS OF VAGINOPLASTY WITH ACELLULAR DERMAL MATRIX AND MIXED PARTICLES GRAFT].
abstract: OBJECTIVE
  To evaluate the effectiveness or acellular dermal matrix (ADM) with autologous buccal micro mucosa and micro skin graft in vaginoplasty.
  
  
  METHODS
  A retrospective analysis was made on the clinical data of 67 patients with vaginal agenesis treated between July 2006 and June 2013. ADM and mixed particles were used in 20 cases (ADM group) and mixed particles graft in 47 cases (control group) in vaginoplasty. There was no significant difference in age between 2 groups (t=0.233, P=0.816). The depth, diameter, and volume of neovagina, epithelization time, stent needing time, and female sexual function index (FSFI) score were compared between 2 groups.
  
  
  RESULTS
  There was no significant difference in operation time and amount of bleeding between 2 groups (t = -1.922, P = 0.059; t = 0.398, P = 0.692). The patients were followed up 11-38 months (mean, 16.08 months). Fifteen cases in ADM group and 29 cases in control group had sexual life after operation. Bleeding after operation occurred in 6 cases (2 in ADM group and 4 in control group). No stenosis was observed. Difference in epithelization time was not statistically significant (t = -1.938, P = 0.057). However, the stent needing time of ADM group was significantly shorter than that of control group (t = 7.020, P = 0.000). The neovagina was ideal in wetness degree, smoothness, flexibility, and hairlessness during follow-up. The depth, diameter, and volume of vagina had no significant difference between 2 groups (P > 0.05) at last follow-up, which were close to normal vagina. The other patients had normal sexual function except 1 patient whose FSFI score was less than 23; no statistically significant difference was found in FSFI score between 2 groups (P > 0.05).
  
  
  CONCLUSIONS
  On the basis of mixed particles grafting, the ADM could improve trestle structure for resisting contracture. The effectiveness is better than merely mixed particles graft. The procedure has satisfactory anatomical and functional results.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Senkai
authors.initials: S
authors.lastname: Ll
authors.forename: Chuande
authors.initials: C
authors.lastname: Zhou
authors.forename: Fengyong
authors.initials: F
authors.lastname: Li
authors.forename: Yujiao
authors.initials: Y
authors.lastname: Cao
authors.forename: Siya
authors.initials: S
authors.lastname: Zhang
authors.forename: Shuyi
authors.initials: S
authors.lastname: Wei
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D062088:Acellular Dermis; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D009061:Mouth Mucosa; D061646:Operative Time; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D012867:Skin; D016038:Skin Transplantation; D017768:Skin, Artificial; D019737:Transplants; D016896:Treatment Outcome; D014621:Vagina / Q000601:surgery