title: Synthesis of tricyclic quinazolinones via intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones.
abstract: Bioactive tricyclic quinazolines class of 3,4-dihydro-1H-pyrimido[2,1-b]quinazolin-6(2H)-ones I and 2,3-dihydroimidazo[2,1-b]quinazolin-5(1H)-ones II were synthesized by the formic acid-catalyzed intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones 1 in high yields. A plausible mechanism of the cyclization step is proposed.
authors.affiliation: Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Neuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning, 437100, China.
authors.forename: Xuhong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Neuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning, 437100, China.
authors.forename: Minghu
authors.initials: M
authors.lastname: Wu
authors.affiliation: Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Neuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning, 437100, China.
authors.forename: Shaofa
authors.initials: S
authors.lastname: Sun
authors.affiliation: Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
authors.forename: Changfeng
authors.initials: C
authors.lastname: Huang
authors.affiliation: Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Neuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning, 437100, China.
authors.forename: Haibing
authors.initials: H
authors.lastname: Guo
authors.affiliation: Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Neuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning, 437100, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Chemistry, William Paterson University, 300 Pompton Rd, Wayne, NJ, 07470, USA.
authors.forename: John
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Chemistry, William Paterson University, 300 Pompton Rd, Wayne, NJ, 07470, USA. xingy@wpunj.edu.
authors.forename: Yalan
authors.initials: Y
authors.lastname: Xing
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D052999:Quinazolinones
keywords: Guanidines; Intramolecular cyclization; Tricyclic quinazoline