title: Changes in the plasma levels of several bone markers in newborn calves during the first two days of life.
abstract: The fluctuations in the plasma levels of several bone markers were investigated in newborn calves. Experiment 1 monitored the postnatal changes in the plasma levels of tartrate-resistant acid phosphatase isoform 5b (TRAP5b), total alkaline phosphatase (t-ALP) and bone-specific alkaline phosphatase (BAP) in four calves. These markers increased significantly from 9-20 hr after the first colostrum-suckling compared with the values immediately after birth. Experiment 2 evaluated changes in the plasma TRAP5b, t-ALP, BAP and type I collagen cross-linked N-telopeptide (NTx) levels within 2 days post-birth in five calves with successful passive immunization via colostrum (non-deficient group) and five others with poor colostrum intake (deficient group). The non-deficient group had significantly higher plasma levels of the four parameters around 12 hr of life compared with the deficient group. The results suggest that the increase in plasma bone markers in calves in the first day of life is related to the colostrum intake.
authors.affiliation: Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Hatate
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Shinya
authors.forename: Asako
authors.initials: A
authors.lastname: Matsuo-Sato
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Bhuminand
authors.initials: B
authors.lastname: Devkota
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takahashi
authors.forename: Toichi
authors.initials: T
authors.lastname: Hirata
authors.forename: Norio
authors.initials: N
authors.lastname: Yamagishi
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D001846:Bone Development; D001842:Bone and Bones / Q000378:metabolism*; D002417:Cattle; D003126:Colostrum; D005260:Female; D008297:Male
chemical_list: D015415:Biomarkers