title: Association of rs17042171 with chromosome 4q25 with atrial fibrillation in Chinese Han populations.
abstract: OBJECTIVE
  A recent genome-wide association study (GWAS) identified a susceptibility single nucleotide polymorphism (SNP), rs17042171 on 4q25 for atrial fibrillation (AF). The aim of the present study was to investigate whether this association between rs17042171 and AF also exists in Chinese Han populations.
  
  
  METHODS
  It was a case-control study. We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 AF-free controls. Genotyping was performed using the TaqMan allelic discrimination Assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models.
  
  
  RESULTS
  There was strongly significant difference between AF patients and control subjects regarding rs17042171 assumption of additive model (OR=2.20, 95% CI: 1.88-2.57, p=2.00 × 10(-22)), dominant model (OR=2.99; 95% CI: 2.19-4.09; p=6.47 × 10(-12)) and a recessive (OR=2.75; 95% CI: 2.21-3.43; p=1.30 × 10(-19)). In the stratification analysis based on age, gender, hypertension, diabetes and coronary artery disease, there was no significant difference of the associations for rs17042171 among the subgroups.
  
  
  CONCLUSIONS
  Our results indicated that rs17042171 confers an increased risk of AF in Chinese Han Populations and expanded the association to non-European ancestry populations for the first time.
authors.affiliation: Section of Pacing and Electrophysiology, Division of Cardiology, the First Affiliated Hospital of Nanjing Medical University; Nanjing-China. njzfx6@njmu.edu.cn.
authors.forename: Liyan
authors.initials: L
authors.lastname: Zhao
authors.forename: Xin Guang
authors.initials: XG
authors.lastname: Chen
authors.forename: Yaowu
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Fang
authors.forename: Fengxiang
authors.initials: F
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D001281:Atrial Fibrillation / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics