title: The Regulation of Synaptic Protein Turnover.
abstract: Emerging evidence indicates that protein synthesis and degradation are necessary for the remodeling of synapses. These two processes govern cellular protein turnover, are tightly regulated, and are modulated by neuronal activity in time and space. The anisotropic anatomy of the neurons presents a challenge for the study of protein turnover, but the understanding of protein turnover in neurons and its modulation in response to activity can help us to unravel the fine-tuned changes that occur at synapses in response to activity. Here we review the key experimental evidence demonstrating the role of protein synthesis and degradation in synaptic plasticity, as well as the turnover rates of specific neuronal proteins.
authors.affiliation: From the Department of Synaptic Plasticity, Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Alvarez-Castelao
authors.affiliation: From the Department of Synaptic Plasticity, Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany erin.schuman@brain.mpg.de.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Schuman
mesh_terms: D000818:Animals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000502:physiology*; D059748:Proteolysis; D013569:Synapses / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins
keywords: neuron; protein degradation; protein synthesis; protein turnover; synapse; synaptic plasticity