title: The copper binding properties of metformin--QCM-D, XPS and nanobead agglomeration.
abstract: Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and L-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. Anja.Boisen@nanotech.dtu.dk Xueling.Quan@nanotech.dtu.dk.
authors.forename: Xueling
authors.initials: X
authors.lastname: Quan
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. Anja.Boisen@nanotech.dtu.dk Xueling.Quan@nanotech.dtu.dk.
authors.forename: Rokon
authors.initials: R
authors.lastname: Uddin
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. Anja.Boisen@nanotech.dtu.dk Xueling.Quan@nanotech.dtu.dk.
authors.forename: Arto
authors.initials: A
authors.lastname: Heiskanen
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. Anja.Boisen@nanotech.dtu.dk Xueling.Quan@nanotech.dtu.dk.
authors.forename: Mattias
authors.initials: M
authors.lastname: Parmvi
authors.affiliation: DTU DANCHIP, Technical University of Denmark, Building 347, Kgs. Lyngby DK-2800, Denmark.
authors.forename: Katharina
authors.initials: K
authors.lastname: Nilson
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. Anja.Boisen@nanotech.dtu.dk Xueling.Quan@nanotech.dtu.dk.
authors.forename: Marco
authors.initials: M
authors.lastname: Donolato
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. Anja.Boisen@nanotech.dtu.dk Xueling.Quan@nanotech.dtu.dk.
authors.forename: Mikkel F
authors.initials: MF
authors.lastname: Hansen
authors.affiliation: Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
authors.forename: Graham
authors.initials: G
authors.lastname: Rena
authors.affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. Anja.Boisen@nanotech.dtu.dk Xueling.Quan@nanotech.dtu.dk.
authors.forename: Anja
authors.initials: A
authors.lastname: Boisen