title: Effects of a Multidisciplinary Approach to Improve Volume of Diagnostic Material in CT-Guided Lung Biopsies.
abstract: BACKGROUND
  Recent publications have emphasized the importance of a multidisciplinary strategy for maximum conservation and utilization of lung biopsy material for advanced testing, which may determine therapy. This paper quantifies the effect of a multidisciplinary strategy implemented to optimize and increase tissue volume in CT-guided transthoracic needle core lung biopsies. The strategy was three-pronged: (1) once there was confidence diagnostic tissue had been obtained and if safe for the patient, additional biopsy passes were performed to further increase volume of biopsy material, (2) biopsy material was placed in multiple cassettes for processing, and (3) all tissue ribbons were conserved when cutting blocks in the histology laboratory. This study quantifies the effects of strategies #1 and #2.
  
  
  METHODS
  This retrospective analysis comparing CT-guided lung biopsies from 2007 and 2012 (before and after multidisciplinary approach implementation) was performed at a single institution. Patient medical records were reviewed and main variables analyzed include biopsy sample size, radiologist, number of blocks submitted, diagnosis, and complications. The biopsy sample size measured was considered to be directly proportional to tissue volume in the block.
  
  
  RESULTS
  Biopsy sample size increased 2.5 fold with the average total biopsy sample size increasing from 1.0 cm (0.9-1.1 cm) in 2007 to 2.5 cm (2.3-2.8 cm) in 2012 (P<0.0001). The improvement was statistically significant for each individual radiologist. During the same time, the rate of pneumothorax requiring chest tube placement decreased from 15% to 7% (P = 0.065). No other major complications were identified. The proportion of tumor within the biopsy material was similar at 28% (23%-33%) and 35% (30%-40%) for 2007 and 2012, respectively. The number of cases with at least two blocks available for testing increased from 10.7% to 96.4% (P<0.0001).
  
  
  CONCLUSIONS
  The effect of this multidisciplinary strategy to CT-guided lung biopsies was effective in significantly increasing tissue volume and number of blocks available for advanced diagnostic testing.
authors.affiliation: Department of Pathology, St. Bernards Medical Center, Jonesboro, AR, United States of America; Doctors' Anatomic Pathology Services, Jonesboro, AR, United States of America; PathMD, Jonesboro, AR, United States of America.
authors.forename: Philip E
authors.initials: PE
authors.lastname: Ferguson
authors.affiliation: Department of Public Health, Tulane University, New Orleans, LA, United States of America.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Sales
authors.affiliation: Department of Science and Mathematics, Arkansas State University, Jonesboro, AR, United States of America.
authors.forename: Dalton C
authors.initials: DC
authors.lastname: Hodges
authors.affiliation: Department of Pathology, St. Bernards Medical Center, Jonesboro, AR, United States of America; Doctors' Anatomic Pathology Services, Jonesboro, AR, United States of America.
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Sales
mesh_terms: D000368:Aged; D062005:Biopsy, Large-Core Needle; D005260:Female; D006764:Hospitals, Community; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D033183:Interdisciplinary Communication; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden