title: False-negative cerebrospinal fluid fungal culture results following oral antineoplastic therapy with a 5-fluorouracil derivative.
abstract: OBJECTIVE
  Cryptococcus neoformans, a common opportunistic pathogen among patients with human immunodeficiency virus (HIV) infection, lymphoproliferative disorders and other conditions causing immunosuppression, can be differentiated from other yeasts using biochemical tests as well as culture results and direct histopathological examination.
  
  
  METHODS
  We present a case of a 78-year-old man with Cryptococcal meningitis and false-negative cerebrospinal fluid culture results following receipt of capecitabine.
  
  
  CONCLUSIONS
  Patients receiving immunosuppressive agents are at higher risk of developing invasive fungal infections, and all patient medications should be reviewed to identify those with potential antifungal properties.
authors.affiliation: Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.
authors.forename: W R
authors.initials: WR
authors.lastname: Judd
authors.affiliation: Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Shely
authors.affiliation: Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.
authors.forename: P D
authors.initials: PD
authors.lastname: Ratliff
authors.affiliation: Division of Infectious Diseases, Saint Joseph Hospital, Lexington, KY, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Reymann
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000069287:Capecitabine / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D003453:Cryptococcosis / Q000382:microbiology*; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D005188:False Negative Reactions; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000382:microbiology*
chemical_list: D000970:Antineoplastic Agents; D000069287:Capecitabine; D005472:Fluorouracil
keywords: 5-fluorouracil; Antifungal; Capecitabine; cryptococcus neoformans