title: Regenerated collagen fibers with grooved surface texture: Physicochemical characterization and cytocompatibility.
abstract: A novel type of protein fibers, regenerated collagen fibers (RC) from cattle skin, was prepared through wet-spinning. Due to the combined effect of solvent exchange and subsequent drawing process, the fibers were found to have a grooved surface texture. The grooves provided not only ordered topographical cues, but also increased surface area. Protein content of the RC fibers was confirmed by Fourier Transform infrared spectroscopy (FTIR) and ninhydrin color reaction. The fibers could be readily fabricated into nonwovens or other textiles, owning to their comparable physical properties to other commercialized fibers. Cell growth behavior on RC nonwovens suggested both early adhesion and prompt proliferation. The high moisture regain, good processability, along with the excellent cytocompatibility indicated that the RC fibers and nonwovens developed in this study might offer a good candidate for biomedical and healthcare applications.
authors.affiliation: Engineering Research Center of Technical Textiles, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wu
authors.affiliation: Engineering Research Center of Technical Textiles, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Engineering Research Center of Technical Textiles, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China. Electronic address: hc@dhu.edu.cn.
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
authors.affiliation: Engineering Research Center of Technical Textiles, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Jin
mesh_terms: D000818:Animals; D002417:Cattle; D016923:Cell Death / Q000187:drug effects; D055598:Chemical Phenomena; D003094:Collagen / Q000737:chemistry* / Q000494:pharmacology* / Q000648:ultrastructure; D003116:Color; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects; D008892:Milk / Q000737:chemistry; D051381:Rats; D013025:Glycine max / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D003094:Collagen
keywords: Collagen fiber; Color reaction; Cytocompatiblity; Groove; Nonwoven