title: Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection.
abstract: Some tumor-specific near-infrared (NIR) fluorescent dyes such as indocyanine green (ICG), IDRye800CW, and 5-aminolevulinic acid have been used clinically for detecting tumor margins or micro-cancer lesions. In this study, we evaluated the physicochemical properties of liposomally formulated phospholipid-conjugated ICG, denoted by LP-iDOPE, as a clinically translatable NIR imaging nanoparticle for brain tumors. We also confirmed its brain-tumor-specific biodistribution and its characteristics as the intra-operative NIR imaging nanoparticles for brain tumor surgery. These properties of LP-iDOPE may enable neurosurgeons to achieve more accurate identification and more complete resection of brain tumor.
authors.affiliation: Department of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan; Department of Molecular Virology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan; Molecular Chirality Research Center, Chiba University, Chiba 263-8522, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Suganami
authors.affiliation: Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Iwadate
authors.affiliation: Department of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan; Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Shibata
authors.affiliation: Department of Veterinary Clinical Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Yamashita
authors.affiliation: Department of Veterinary Clinical Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Natsuki
authors.initials: N
authors.lastname: Shinozaki
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan.
authors.forename: Ichio
authors.initials: I
authors.lastname: Aoki
authors.affiliation: Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Naokatsu
authors.initials: N
authors.lastname: Saeki
authors.affiliation: Department of Molecular Virology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shirasawa
authors.affiliation: Department of Veterinary Clinical Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Department of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan; Molecular Chirality Research Center, Chiba University, Chiba 263-8522, Japan. Electronic address: yutaka_tamura@faculty.chiba-u.jp.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tamura
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000601:surgery; D002626:Chemistry, Pharmaceutical; D007208:Indocyanine Green / Q000008:administration & dosage*; D008081:Liposomes / Q000737:chemistry; D008297:Male; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D051381:Rats; D011916:Rats, Inbred F344; D013050:Spectrometry, Fluorescence; D019265:Spectroscopy, Near-Infrared
chemical_list: D008081:Liposomes; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; C094877:dioleoyl phosphatidylethanolamine; C017251:1,2-oleoylphosphatidylcholine; D007208:Indocyanine Green
keywords: Brain tumor surgery; Indocyanine green (ICG); Intra-operative imaging; Liposome; Near-infrared (NIR)