title: Study of Antitumor Activity of Sodium Phenylbutyrate, Histon Deacetylase Inhibitor, on Ehrlich Carcinoma Model.
abstract: Antitumor activity of sodium phenylbutyrate was studied on 120 outbred female mice with transplanted Ehrlich ascites carcinoma. The animals received the drug in doses of 400, 800, and 1200 mg/kg with drinking water daily for 21 days. The antitumor effect was evaluated by tumor growth inhibition and lifespan prolongation. Phenylbutyrate in the dose of 800 mg/kg was most effective. The drug inhibited the tumor growth by 71%, prolonged the lifespan of animals by 28, and was low-toxic.
authors.affiliation: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia. nick.fadeev2010@yandex.ru.
authors.forename: N P
authors.initials: NP
authors.lastname: Fadeev
authors.affiliation: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: R I
authors.initials: RI
authors.lastname: Kharisov
authors.affiliation: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Kovan'ko
authors.affiliation: Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Pustovalov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D021461:Animals, Outbred Strains; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D005260:Female; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D007273:Injections, Intramuscular; D008136:Longevity / Q000187:drug effects; D051379:Mice; D009368:Neoplasm Transplantation; D010654:Phenylbutyrates / Q000494:pharmacology*; D016019:Survival Analysis; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D010654:Phenylbutyrates; C075773:4-phenylbutyric acid
keywords: Ehrlich tumor; histon deacetylase inhibitor; sodium phenylbutyrate; toxicity