title: Estimation of the efficacy of chemo-radiotherapy on tumor regression in the patients with laryngeal cancer via computerized tomography using the Cavalieri method.
abstract: CONCLUSIONS
  Calculating tumor volume using the Cavalieri method in laryngeal tumors before and after treatment may be useful to optimize the treatment and to minimize the side-effects of radiotherapy.
  
  
  OBJECTIVE
  This study aimed to estimate the pre-treatment and post-treatment tumor volumes of the patients to whom radiotherapy or radio-chemotherapy was applied as a treatment using Cavalieri's Principle as a stereological method and to assess tumor regression rates in the patients with Laryngeal Squamous Cell Carcinoma (LSCC) statistically.
  
  
  METHODS
  Sixteen patients (eight patients with stage T3 and eight patients with stage T4) diagnosed with LCCC bearing the appropriate characteristics to criteria in the otorhinolaryngology clinic were included. Patients had computerized tomography (CT) scans in the axial plane before treatment and 2 months after the treatment. Pre-treatment and post-treatment tumor volumes on CT images were calculated using Cavalieri's principle as a stereological method and then compared.
  
  
  RESULTS
  Average tumor volumes in patients with stage T3 before and after treatment were 10.12 ± 3.58 cm(3) and 1.33 ± 1.74 cm(3), respectively (p = 0.008). These volumes were 11.92 ± 4.61 cm(3) and 2.17 ± 2.34 cm(3) (p = 0.008) for patients with stage T4, respectively. Post-treatment tumor volumes were statistically reduced compared to pre-treatment volumes in all stages.
authors.affiliation: a Department of Otorhinolaryngology , Ataturk University, School of Medicine , Erzurum , Turkey ;
authors.forename: Fatih
authors.initials: F
authors.lastname: Bingol
authors.affiliation: a Department of Otorhinolaryngology , Ataturk University, School of Medicine , Erzurum , Turkey ;
authors.forename: Ozgur
authors.initials: O
authors.lastname: Yoruk
authors.affiliation: a Department of Otorhinolaryngology , Ataturk University, School of Medicine , Erzurum , Turkey ;
authors.forename: Buket Ozel
authors.initials: BO
authors.lastname: Bingol
authors.affiliation: b Department of Radiation Oncology , Ataturk University, School of Medicine , Erzurum , Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Erdemci
authors.affiliation: a Department of Otorhinolaryngology , Ataturk University, School of Medicine , Erzurum , Turkey ;
authors.forename: Ozalkan
authors.initials: O
authors.lastname: Ozkan
authors.affiliation: a Department of Otorhinolaryngology , Ataturk University, School of Medicine , Erzurum , Turkey ;
authors.forename: Muhammet Recai
authors.initials: MR
authors.lastname: Mazlumoglu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009367:Neoplasm Staging / Q000379:methods*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: Cavalieri; Laryngeal squamous cell carcinoma; radiotherapy; stereology