title: Assessment of left atrial appendage function during sinus rhythm in patients with obstructive sleep apnea.
abstract: OBJECTIVE
  Obstructive sleep apnea (OSA) is associated with thromboembolic events. Compromised left atrial appendage (LAA) function due to left ventricular (LV) performance abnormality, often present in patients with OSA, may play an important role. The purpose of this study is to evaluate LV and LAA mechanical functions during sinus rhythm (SR) in patients with OSA.
  
  
  METHODS
  LV and LAA functions were assessed in 43 OSA patients and compared with that of 20 control patients in SR. Tissue Doppler velocities of the LAA apex and emptying velocities (EV) of LAA were obtained on parasternal short-axis view.
  
  
  RESULTS
  The baseline clinical characteristics were similar except for AHI (apnea-hypopnea index), minimal SaO2, mean SaO2, hypertension, and body-surface area. Most of the LV echocardiographic parameters significantly deteriorated in OSA patients in comparison with those in the control group. LAA EV, LAA systolic relaxation velocity (SM), LAA early-diastolic velocity (EM), LAA contraction velocity (AM), left atrial (LA) minimum volume index, LA ejection fraction, LA conduit volume index, and LA reservoir volume index were lower in OSA patients compared with those in the control group (p<0.05). LAA AM was negatively correlated with AHI and the ratio of peak early diastolic flow velocity (E) to early-diastolic (E') and positively correlated with LA conduit volume (p<0.05). Multiple predictors for LAA AM were AHI, presence of diastolic dysfunction, and E/E' values (p<0.05).
  
  
  CONCLUSIONS
  LAA mechanical function is significantly depressed in patients with OSA and SR. LAA dysfunction may predispose these patients to thromboembolic events. The evaluation of LAA mechanical function by tissue Doppler study using transthoracic echocardiography (TTE) may become an alternative for routine work-up in OSA patients.
authors.affiliation: Department of Cardiology, Faculty of Cardiology, Sakarya University; Sakarya-Turkey. ceramos3@gmail.com.
authors.forename: Mustafa Gökhan
authors.initials: MG
authors.lastname: Vural
authors.forename: Süha
authors.initials: S
authors.lastname: Çetin
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Gündüz
authors.forename: Özge
authors.initials: Ö
authors.lastname: Özcan Abacıoğlu
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
authors.forename: Hikmet
authors.initials: H
authors.lastname: Fırat
authors.forename: Ekrem
authors.initials: E
authors.lastname: Yeter
mesh_terms: D000328:Adult; D020517:Atrial Appendage / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016279:Atrial Function, Left; D015331:Cohort Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D016277:Ventricular Function, Left