title: Toxic heritage: Maternal transfer of pyrethroid insecticides and sunscreen agents in dolphins from Brazil.
abstract: Pyrethroids (PYR) and UV filters (UVF) were investigated in tissues of paired mother-fetus dolphins from Brazilian coast in order to investigate the possibility of maternal transfer of these emerging contaminants. Comparison of PYR and UVF concentrations in maternal and fetal blubber revealed Franciscana transferred efficiently both contaminants to fetuses (F/M > 1) and Guiana dolphin transferred efficiently PYR to fetuses (F/M > 1) different than UVF (F/M < 1). PYR and UVF concentrations in fetuses were the highest-ever reported in biota (up to 6640 and 11,530 ng/g lw, respectively). Muscle was the organ with the highest PYR and UVF concentrations (p < 0.001), suggesting that these two classes of emerging contaminants may have more affinity for proteins than for lipids. The high PYR and UVF concentrations found in fetuses demonstrate these compounds are efficiently transferred through placenta. This study is the first to report maternal transfer of pyrethroids and UV filters in marine mammals.
authors.affiliation: Radioisotopes Laboratory Eduardo Penna Franca (LREPF), Biophysics Institute Carlos Chagas Filho (IBCCF), Federal University of Rio de Janeiro (UFRJ), Brazil; Aquatic Mammals and Bioindicator Laboratory (MAQUA), School of Oceanography, Rio de Janeiro State University (UERJ), Brazil; Laboratório de Biologia e Conservação da Megafauna Marinha - Biopesca - Instituto de Biociências, Universidade Estadual Paulista, Unesp, Campus Litoral Paulista, Brazil.
authors.forename: Mariana B
authors.initials: MB
authors.lastname: Alonso
authors.affiliation: Department of Environmental Chemistry, IDAEA, CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Feo
authors.affiliation: Department of Environmental Chemistry, IDAEA, CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: Cayo
authors.initials: C
authors.lastname: Corcellas
authors.affiliation: Department of Environmental Chemistry, IDAEA, CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Gago-Ferrero
authors.affiliation: Laboratório de Biologia e Conservação da Megafauna Marinha - Biopesca - Instituto de Biociências, Universidade Estadual Paulista, Unesp, Campus Litoral Paulista, Brazil.
authors.forename: Carolina P
authors.initials: CP
authors.lastname: Bertozzi
authors.affiliation: Laboratório de Biologia e Conservação da Megafauna Marinha - Biopesca - Instituto de Biociências, Universidade Estadual Paulista, Unesp, Campus Litoral Paulista, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Marigo
authors.affiliation: Projeto Boto Cinza, Sepetiba, Rio de Janeiro, Brazil.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Flach
authors.affiliation: Associação de Pesquisa e Preservação de Ecossistemas Aquáticos (AQUASIS), Caucaia, Ceará, Brazil.
authors.forename: Ana Carolina O
authors.initials: AC
authors.lastname: Meirelles
authors.affiliation: Associação de Pesquisa e Preservação de Ecossistemas Aquáticos (AQUASIS), Caucaia, Ceará, Brazil.
authors.forename: Vitor L
authors.initials: VL
authors.lastname: Carvalho
authors.affiliation: Aquatic Mammals and Bioindicator Laboratory (MAQUA), School of Oceanography, Rio de Janeiro State University (UERJ), Brazil.
authors.forename: Alexandre F
authors.initials: AF
authors.lastname: Azevedo
authors.affiliation: Radioisotopes Laboratory Eduardo Penna Franca (LREPF), Biophysics Institute Carlos Chagas Filho (IBCCF), Federal University of Rio de Janeiro (UFRJ), Brazil.
authors.forename: João Paulo M
authors.initials: JP
authors.lastname: Torres
authors.affiliation: Aquatic Mammals and Bioindicator Laboratory (MAQUA), School of Oceanography, Rio de Janeiro State University (UERJ), Brazil.
authors.forename: José
authors.initials: J
authors.lastname: Lailson-Brito
authors.affiliation: Radioisotopes Laboratory Eduardo Penna Franca (LREPF), Biophysics Institute Carlos Chagas Filho (IBCCF), Federal University of Rio de Janeiro (UFRJ), Brazil.
authors.forename: Olaf
authors.initials: O
authors.lastname: Malm
authors.affiliation: Department of Environmental Chemistry, IDAEA, CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: M Silvia
authors.initials: MS
authors.lastname: Diaz-Cruz
authors.affiliation: Department of Environmental Chemistry, IDAEA, CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain. Electronic address: eeeqam@cid.csic.es.
authors.forename: Ethel
authors.initials: E
authors.lastname: Eljarrat
authors.affiliation: Department of Environmental Chemistry, IDAEA, CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: Damià
authors.initials: D
authors.lastname: Barceló
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001938:Brazil; D004289:Dolphins / Q000196:embryology / Q000378:metabolism*; D005260:Female; D007306:Insecticides / Q000032:analysis / Q000493:pharmacokinetics*; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011722:Pyrethrins / Q000032:analysis / Q000493:pharmacokinetics*; D013473:Sunscreening Agents / Q000032:analysis / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D007306:Insecticides; D011722:Pyrethrins; D013473:Sunscreening Agents; D014874:Water Pollutants, Chemical
keywords: Cetacean; Emerging pesticides; Fetus; Lactational uptake; Transplacental transfer; UV filters