title: Increased stereotypy in conditional Cxcr4 knockout mice.
abstract: Chemokines play important roles in the central nervous system, including mediating neuroinflammation and guiding the intracortical migration of interneurons during development. Alteration in parvalbumin-positive interneurons is a key neuropathological hallmark of multiple mental conditions. We recently reported a significant reduction in the expression of CXCL12 in olfactory neurons from sporadic cases with schizophrenia compared with matched controls, suggesting a role for CXCR4/CXCL12 signaling in mental conditions. Thus, we depleted the chemokine receptor Cxcr4 from mice using the parvalbumin-2A-Cre line. The conditional knockout mice exhibited a unique behavioral phenotype involving increased stereotypy. Stereotypy is observed in many psychiatric conditions, including schizophrenia, autism, and dementia. Thus, the Cxcr4 conditional knockout mice may serve as a model for this symptomatic feature.
authors.affiliation: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
authors.forename: Tyler
authors.initials: T
authors.lastname: Cash-Padgett
authors.affiliation: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
authors.forename: Akira
authors.initials: A
authors.lastname: Sawa
authors.affiliation: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States. Electronic address: hjaarop1@jhmi.edu.
authors.forename: Hanna
authors.initials: H
authors.lastname: Jaaro-Peled
mesh_terms: D000818:Animals; D008297:Male; D018782:Maze Learning; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism; D010320:Parvalbumins / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000235:genetics*; D013216:Reflex, Startle; D013239:Stereotyped Behavior
chemical_list: C514936:CXCR4 protein, mouse; D010320:Parvalbumins; D019718:Receptors, CXCR4
keywords: Behavior; CXCR4; Chemokines; Mouse models; Parvalbumin interneurons; Stereotypy