title: Clinical management of resistance evolution in a bacterial infection: A case study.
abstract: We report the case of a patient with a chronic bacterial infection that could not be cured. Drug treatment became progressively less effective due to antibiotic resistance, and the patient died, in effect from overwhelming evolution. Even though the evolution of drug resistance was recognized as a major threat, and the fundamentals of drug resistance evolution are well understood, it was impossible to make evidence-based decisions about the evolutionary risks associated with the various treatment options. We present this case to illustrate the urgent need for translational research in the evolutionary medicine of antibiotic resistance.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA robertwo@med.umich.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Woods
authors.affiliation: Department of Biology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park PA 16802, USA Department of Entomology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park PA 16802, USA.
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Read
keywords: Enterobacter; MRSA; antibiotic resistance; clinical decisions; evolutionary risk; resistance management