title: [A Case of Early Recurrence after Esophagectomy for Cancer Following Neoadjuvant Chemotherapy Resulting in a Complete Response of the Primary Lesion].
abstract: A 78-year-old man presented with a chief complaint of dysphagia. He was diagnosed with an esophageal squamous cell carcinoma and referred to our hospital. A type 3 tumor was identified in the lower thoracic esophagus on endoscopy. A CT scan revealed lymph node metastases at the No. 3 station. The clinical stage of the tumor was T3N1M0, Stage III. The patient was treated with neoadjuvant chemotherapy consisting of2 courses of5 -FU and nedaplatin. He had a partial response and underwent a radical esophagectomy. Histopathological examination revealed a complete response of the primary lesion and viable cancer cells in only one lymph node at the No. 3 station. No adjuvant chemotherapy was administered. Three months after the operation, recurrences in the upper abdominal multiple para-aortic lymph nodes were detected. Although he was treated with chemotherapy, he died 7 months after the operation. Even after a complete response of the primary lesion was achieved using neoadjuvant chemotherapy, esophageal cancer with lymph node metastasis has the potential for an early recurrence. Therefore, we should consider adjuvant therapy in such cases.
authors.affiliation: Dept. of Digestive Surgery, Chiba Cancer Center.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Saito
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nabeya
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Takiguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.forename: Osamu
authors.initials: O
authors.lastname: Kainuma
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Soda
authors.forename: Toru
authors.initials: T
authors.lastname: Tonooka
authors.forename: Hidehito
authors.initials: H
authors.lastname: Arimitsu
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yanagibashi
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Chibana
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ishige
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hironaka
authors.forename: Matsuo
authors.initials: M
authors.lastname: Nagata
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016629:Esophagectomy; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012008:Recurrence; D013997:Time Factors
chemical_list: D009944:Organoplatinum Compounds; C053989:nedaplatin; D005472:Fluorouracil