title: Understanding the direction of evolution in Burkholderia glumae through comparative genomics.
abstract: Members of the genus Burkholderia occupy remarkably diverse niches, with genome sizes ranging from ~3.75 to 11.29 Mbp. The genome of Burkholderia glumae ranges in size from ~5.81 to 7.89 Mbp. Unlike other plant pathogenic bacteria, B. glumae can infect a wide range of monocot and dicot plants. Comparative genome analysis of B. glumae strains can provide insight into genome variation as well as differential features of whole metabolism or pathways between multiple strains of B. glumae infecting the same host. Comparative analysis of complete genomes among B. glumae BGR1, B. glumae LMG 2196, and B. glumae PG1 revealed the largest departmentalization of genes onto separate replicons in B. glumae BGR1 and considerable downsizing of the genome in B. glumae LMG 2196. In addition, the presence of large-scale evolutionary events such as rearrangement and inversion and the development of highly specialized systems were found to be related to virulence-associated features in the three B. glumae strains. This connection may explain why this bacterium broadens its host range and reinforces its interaction with hosts.
authors.affiliation: Department of Microbiology, Pusan National University, Pusan, 609-735, Republic of Korea.
authors.forename: Hyun-Hee
authors.initials: HH
authors.lastname: Lee
authors.affiliation: Department of Microbiology, Pusan National University, Pusan, 609-735, Republic of Korea.
authors.forename: Jungwook
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Microbiology, Pusan National University, Pusan, 609-735, Republic of Korea.
authors.forename: Jinnyun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Microbiology, Pusan National University, Pusan, 609-735, Republic of Korea.
authors.forename: Inmyoung
authors.initials: I
authors.lastname: Park
authors.affiliation: Department of Microbiology, Pusan National University, Pusan, 609-735, Republic of Korea. yseo2011@pusan.ac.kr.
authors.forename: Young-Su
authors.initials: YS
authors.lastname: Seo
mesh_terms: D005075:Biological Evolution; D019117:Burkholderia / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D015321:Gene Rearrangement; D016680:Genome, Bacterial; D055106:Genome-Wide Association Study; D023281:Genomics / Q000379:methods; D053858:Metabolic Networks and Pathways; D010935:Plant Diseases / Q000382:microbiology; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D014774:Virulence / Q000235:genetics
chemical_list: D010940:Plant Proteins
keywords: Burkholderia glumae; Comparative genomics; Plant pathogen; Virulence factor