title: The impact of vitamin D levels on glycemic control and bone  mineral density in postmenopausal women with type 2 diabetes.
abstract: OBJECTIVE
  Whether glycemic control contributes to a decreased number of fractures or favorably impacts bone density in patients with type 2 diabetes mellitus (T2DM)has not been well established. Vitamin D (25 (OH) D3) deficiency appears to be related to glycemic control in patients with T2DM. The aim of this study was to determine the relationship between 25 (OH) D3 levels, glycemic control, bone mineral density (BMD), and the development of osteoporotic fractures (OPF) in postmenopausal women with T2DM.
  
  
  METHODS
  We reviewed the charts of 110 postmenopausal women diagnosed with T2DM. Glycosylated hemoglobin A1c (HbA1c) values over the previous 5 years were recorded and an average was obtained. Based on these values,the patients were divided into three groups: optimal,suboptimal, and poor control. Bone mineral density and 25(OH) D3 levels were also recorded.
  
  
  RESULTS
  In the group of patients with poorly controlled T2DM, 25 (OH) D3 levels were not significantly lower in comparison with the optimal control group 19.29 ± 7.70 vs 17.26 ± 6.93 (p = 0.53). No statistically significant linear relationship between HbA1c and 25 (OH) D3 levels( r(s) = −0.17, p = 0.06) was established. The frequency of osteoporosis and osteopenia was not significantly different between groups. The group with optimal glycemic control had an increased number of OPF events (p = 0.04).
  
  
  CONCLUSIONS
  We do not appreciate a significant relationship between 25 (OH) D3 levels and glucose control or OPF. Therefore, more studies are needed to identify the specific effect of 25 (OH) D3 in T2DM physiopathology.
authors.forename: I
authors.initials: I
authors.lastname: Perez-Diaz
authors.forename: G
authors.initials: G
authors.lastname: Sebastian-Barajas
authors.forename: Z G
authors.initials: ZG
authors.lastname: Hernandez-Flores
authors.forename: R
authors.initials: R
authors.lastname: Rivera-Moscoso
authors.forename: H K
authors.initials: HK
authors.lastname: Osorio-Landa
authors.forename: A
authors.initials: A
authors.lastname: Flores-Rebollar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D015519:Bone Density; D002112:Calcifediol / Q000097:blood / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D058866:Osteoporotic Fractures / Q000097:blood / Q000378:metabolism*; D017698:Postmenopause / Q000097:blood / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000097:blood / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D002112:Calcifediol; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human