title: Relationship Between Serum Fetuin-A Levels and Carotid Intima-media Thickness in Turkish Patients with Mild to Moderate Psoriasis. A Case-control Study.
abstract: Previous studies have associated severe psoriasis and psoriatic arthritis with an increased risk of atherosclerosis. However, the association between patients with mild-to-moderate plaque-type psoriasis and atherosclerosis has yet to be studied in depth. This study investigates a) possible correlations between carotid intima-media thickness (CIMT) and serum fetuin-A levels in patients with mild-to-moderate psoriasis and b) correlations between psoriasis severity index (PASI) and fetuin-A levels. The latter correlation was recently reported to be important for wound healing and vascular calcification. In this prospective study, a total of 70 patients with mild-to-moderate psoriasis and 66 control participants were included. PASI, CIMT, and serum fetuin-A levels were examined in all patients. Although the difference in fetuin-A values was not statistically significant between patients with mild-to-moderate plaque-type psoriasis and control groups (P=0.401), the CIMT levels in the psoriasis group were significantly higher than the control group (P=0.002). There were no correlations among fetuin-A levels, CIMT, and PASI. This study establishes an association between mild to moderate psoriasis and atherosclerosis. This study also concludes that, similarly to patients with severe psoriasis, CIMT levels are a better indicator of cardiovascular risk than serum fetuin-A levels in patients diagnosed with mild-to-moderate plaque-type psoriasis.
authors.affiliation: Assist. Professor Belkız Uyar, MD, 35240 172/2 Fevzipaşa Bulvarı Basmane , Izmir, Turkey; belkisuyar@gmail.com.
authors.forename: Belkiz
authors.initials: B
authors.lastname: Uyar
authors.forename: Muhittin
authors.initials: M
authors.lastname: Akyildiz
authors.forename: Aynur
authors.initials: A
authors.lastname: Solak
authors.forename: Berhan
authors.initials: B
authors.lastname: Genc
authors.forename: Ali
authors.initials: A
authors.lastname: Saklamaz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D014421:Turkey; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D060749:alpha-2-HS-Glycoprotein