title: A new class of drugs for systolic heart failure: The PARADIGM-HF study.
abstract: The PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) found a combination drug containing sacubitril (a neprilysin inhibitor) and valsartan (an angiotensin II receptor blocker) superior to enalapril (an angiotensin-converting enzyme inhibitor) in patients with systolic heart failure. Recently approved by the US Food and Drug Administration, sacubitril-valsartan is the first new drug in over a decade to decrease death rates in patients with systolic heart failure.
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Marwa A
authors.initials: MA
authors.lastname: Sabe
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Miriam S
authors.initials: MS
authors.lastname: Jacob
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA. E-mail: taylord2@ccf.org.
authors.forename: David O
authors.initials: DO
authors.lastname: Taylor
mesh_terms: D000613:Aminobutyrates / Q000627:therapeutic use*; D000799:Angioedema / Q000139:chemically induced; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use*; D001713:Biphenyl Compounds; D002318:Cardiovascular Diseases / Q000401:mortality; D003371:Cough / Q000139:chemically induced; D004311:Double-Blind Method; D004338:Drug Combinations; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D054143:Heart Failure, Systolic / Q000188:drug therapy*; D006760:Hospitalization; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000037:antagonists & inhibitors*; D051437:Renal Insufficiency / Q000139:chemically induced; D013777:Tetrazoles / Q000627:therapeutic use*; D000068756:Valsartan
chemical_list: D000613:Aminobutyrates; D057911:Angiotensin Receptor Antagonists; D001713:Biphenyl Compounds; D004338:Drug Combinations; D013777:Tetrazoles; D004656:Enalapril; D000068756:Valsartan; D015260:Neprilysin; C549068:sacubitril and valsartan sodium hydrate drug combination