title: How can clinicians detect and treat autism early? Methodological trends of technology use in research.
abstract: We reviewed original research papers that used quantifiable technology to detect early autism spectrum disorder (ASD) and identified 376 studies from 34 countries from 1965 to 2013. Publications have increased significantly since 2000, with most coming from the USA. Electroencephalogram, magnetic resonance imaging and eye tracking were the most frequently used technologies.
  
  
  CONCLUSIONS
  The use of quantifiable technology to detect early ASD has increased in recent decades, but has had limited impact on early detection and treatment. Further scientific developments are anticipated, and we hope that they will increasingly be used in clinical practice for early ASD screening, diagnosis and intervention.
authors.affiliation: Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.|Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Bölte
authors.affiliation: Institute of Physiology, Research Unit iDN (interdisciplinary Developmental Neuroscience), Medical University of Graz, Graz, Austria.
authors.forename: K D
authors.initials: KD
authors.lastname: Bartl-Pokorny
authors.affiliation: Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Jonsson
authors.affiliation: Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.|Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Berggren
authors.affiliation: Institute of Physiology, Research Unit iDN (interdisciplinary Developmental Neuroscience), Medical University of Graz, Graz, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Kostrzewa
authors.affiliation: Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.|Department of Psychology, Uppsala Child and Babylab, Uppsala University, Uppsala, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Falck-Ytter
authors.affiliation: Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Einspieler
authors.affiliation: Institute of Physiology, Research Unit iDN (interdisciplinary Developmental Neuroscience), Medical University of Graz, Graz, Austria.|Department of Electrical, Electronic and Computer Engineering, Technical University, Munich, Munich, Germany.
authors.forename: F B
authors.initials: FB
authors.lastname: Pokorny
authors.affiliation: Centre for Brain and Cognitive Development, Birkbeck College, University of London, London, UK.
authors.forename: E J H
authors.initials: EJ
authors.lastname: Jones
authors.affiliation: Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Roeyers
authors.affiliation: Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: T
authors.initials: T
authors.lastname: Charman
authors.affiliation: Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.|Institute of Physiology, Research Unit iDN (interdisciplinary Developmental Neuroscience), Medical University of Graz, Graz, Austria.
authors.forename: P B
authors.initials: PB
authors.lastname: Marschik
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis* / Q000628:therapy*; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging
keywords: Early autism spectrum disorder; Electroencephalogram; Eye-tracking technology; Magnetic resonance imaging; Review