title: Decreased Plasma Histidine Level Predicts Risk of Relapse in Patients with Ulcerative Colitis in Remission.
abstract: Ulcerative colitis (UC) is characterized by chronic intestinal inflammation. Patients with UC have repeated remission and relapse. Clinical biomarkers that can predict relapse in UC patients in remission have not been identified. To facilitate the prediction of relapse of UC, we investigated the potential of novel multivariate indexes using statistical modeling of plasma free amino acid (PFAA) concentrations. We measured fasting PFAA concentrations in 369 UC patients in clinical remission, and 355 were observed prospectively for up to 1 year. Relapse rate within 1 year was 23% (82 of 355 patients). The age- and gender-adjusted hazard ratio for the lowest quartile compared with the highest quartile of plasma histidine concentration was 2.55 (95% confidence interval: 1.41-4.62; p = 0.0020 (log-rank), p for trend = 0.0005). We demonstrated that plasma amino acid profiles in UC patients in clinical remission can predict the risk of relapse within 1 year. Decreased histidine level in PFAAs was associated with increased risk of relapse. Metabolomics could be promising for the establishment of a non-invasive predictive marker in inflammatory bowel disease.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan; Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Hisamatsu
authors.affiliation: Institute for Innovation, Ajinomoto Co. Inc., Kawasaki, Japan.
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ono
authors.affiliation: Institute for Innovation, Ajinomoto Co. Inc., Kawasaki, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Imaizumi
authors.affiliation: Institute for Innovation, Ajinomoto Co. Inc., Kawasaki, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Mori
authors.affiliation: Research Institute, Ajinomoto Pharmaceuticals Co. Ltd., Kawasaki, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Research Institute, Ajinomoto Pharmaceuticals Co. Ltd., Kawasaki, Japan.
authors.forename: Michihide
authors.initials: M
authors.lastname: Uo
authors.affiliation: Research Institute, Ajinomoto Pharmaceuticals Co. Ltd., Kawasaki, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Center for Diagnostic and Therapeutic Endoscopy, Keio University, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Naganuma
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsuoka
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Shinta
authors.initials: S
authors.lastname: Mizuno
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Mina T
authors.initials: MT
authors.lastname: Kitazume
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Yajima
authors.affiliation: Center for Diagnostic and Therapeutic Endoscopy, Keio University, Tokyo, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ogata
authors.affiliation: Center for Preventive Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Iwao
authors.affiliation: Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Kanai
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003093:Colitis, Ulcerative / Q000097:blood* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006639:Histidine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D006639:Histidine