title: Two-year clinical outcome in patients with small coronary artery disease treated with everolimus- versus paclitaxel-eluting stenting.
abstract: Percutaneous coronary interventions involving small coronary vessels represent a true challenge because of the increased risk of restenosis and adverse outcomes. We evaluated the 2-year clinical outcomes between single everolimus-eluting stents (EES) and paclitaxel-eluting stents (PES) in small coronary artery disease.
  
  
  
  From the data of SACRA (SmAll CoronaRy Artery treated by TAXUS Liberté) and PLUM (PROMUS/Xience V Everolimus-ELUting Coronary Stent for sMall coronary artery disease) registries, 245 patients with 258 lesions and 264 patients with 279 lesions, respectively, were enrolled in this study.
  
  
  
  The 2-year clinical driven target lesion revascularization (4.5% vs. 10.6%, p=0.01) and target vessel revascularization (8.0% vs. 13.9%, p=0.03) rates were significantly lower in the EES group compared with the PES group. Major adverse cardiac events in the EES group tended to be lower than those in the PES group (8.7% vs. 14.3%, p=0.05). On the other hand, all new lesions for remote target vessel revascularization were observed at the proximal site of target lesions in both groups and those rates were not different between the two groups (3.4% vs. 3.3%, p>0.99).
  
  
  
  EES showed better clinical results at 2-year follow-up compared with PES in small coronary artery diseases, however, new lesions at the proximal remote site of the target lesion remain problematic.
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan. Electronic address: yuyatomoya@gmail.com.
authors.forename: Kenya
authors.initials: K
authors.lastname: Nasu
authors.affiliation: Department of Cardiology, The Cardiovascular Institute, Minato-ku, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Oikawa
authors.affiliation: Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Shirai
authors.affiliation: Department of Cardiovascular Medicine, Ayase Heart Hospital, Adachi-ku, Japan.
authors.forename: Hidenari
authors.initials: H
authors.lastname: Hozawa
authors.affiliation: Department of Cardiovascular Medicine, Sapporo Cardio Vascular Clinic, Sapporo, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kashima
authors.affiliation: Department of Cardiology, Kasukabe Chuo General Hospital, Kasukabe, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Tohara
authors.affiliation: Department of Cardiology, Kakogawa East City Hospital, Kakogawa, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kadotani
authors.affiliation: Division of Cardiology, Shuwa General Hospital, Kasukabe, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Gotoh
authors.affiliation: Division of Cardiology, Hoshi General Hospital, Koriyma, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ujiie
authors.affiliation: Department of Cardiology, Daini Okamoto General Hospital, Uji, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Tanabe
authors.affiliation: Cardiovascular Center, Matsumoto Kyoritsu Hospital, Matsumoto, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Abe
authors.affiliation: Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan.
authors.forename: Atsunori
authors.initials: A
authors.lastname: Okamura
authors.affiliation: Department of Cardiology, Kusatsu Heart Center, Kusatsu, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Tsuji
authors.affiliation: Department of Cardiology, Tokyo Metropolitan Police Hospital, Nakano-ku, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Cardiology, Rinku General Medical Center, Izumisano, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Cardiovascular Medicine, Miyagi Prefectural Cardiovascular and Respiratory Center, Kurihara, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Mibiki
authors.affiliation: Department of Cardiology, Itabashi Chuo Medical Center, Itabashi, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ota
authors.affiliation: Department of Cardiology, JR Tokyo General Hospital, Shibuya-ku, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Usui
authors.affiliation: Department of Cardiology, Tokyo-Kita Social Insurance Hospital, Kita-ku, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nakagawa
authors.affiliation: Division of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi, Japan.
authors.forename: Ren
authors.initials: R
authors.lastname: Kawaguchi
authors.affiliation: Department of Cardiology, Tokyo Medical University Hospital, Shinjuku-ku, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Yamashita
authors.affiliation: Division of Cardiology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Serikawa
authors.affiliation: Department of Cardiology, The Cardiovascular Institute, Minato-ku, Japan.
authors.forename: Tadanori
authors.initials: T
authors.lastname: Aizawa
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000628:therapy*; D054855:Drug-Eluting Stents; D000068338:Everolimus; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D017239:Paclitaxel; D062645:Percutaneous Coronary Intervention; D012042:Registries; D019233:Retreatment / Q000706:statistics & numerical data; D013927:Thrombosis / Q000453:epidemiology
chemical_list: D000068338:Everolimus; D017239:Paclitaxel
keywords: Everolimus-eluting stent; Paclitaxel-eluting stent; Small coronary artery disease