title: Therapy strategies in psoriatic arthritis.
abstract: Psoriatic arthritis (PsA) is a heterogeneous condition with a myriad of different clinical presentations. It commonly affects the skin and musculoskeletal system causing psoriasis, peripheral arthritis, axial arthritis, enthesitis and dactylitis. Many patients also have related conditions, such as those within the metabolic syndrome and associated spondyloarthritis (SpA) conditions including inflammatory bowel disease and uveitis. Any therapeutic strategy must be tailored to the individual patient, taking into account her/his complete clinical presentation and comorbidities. New treatment recommendations from the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) provide evidence based recommendations on effective therapies for the management of each different manifestation of PsA, and how treatment may be affected by comorbidities (1). However, the limited evidence comparing different treatment strategies in PsA is recognised as a limitation in these recommendations and further information is detailed below.
authors.affiliation: Leeds Inst. of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK and Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, UK and Div. of Allergy, Immunology and Rheumatology, Univ. of Rochester Medical Center, USA.
authors.forename: Laura C
authors.initials: LC
authors.lastname: Coates
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D001688:Biological Products / Q000009:adverse effects / Q000627:therapeutic use*; D061345:Early Medical Intervention; D019317:Evidence-Based Medicine; D006801:Humans; D057285:Precision Medicine; D011237:Predictive Value of Tests; D012074:Remission Induction; D012307:Risk Factors; D061665:Time-to-Treatment; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D001688:Biological Products