title: Tumor Microenvironment as a New Target for Tumor Immunotherapy of Polysaccharides.
abstract: Many researches show that polysaccharides derived from fungi and plants have strong pharmacological activities such as enhancing the organism immune and anti-tumor function, and have few toxic and side effects. So the polysaccharides show a wide application prospect in the prevention and therapy of tumor. The tumor microenvironment consists of tumor cells and tumor cells' surrounding environment. The tumor microenvironment not only plays a key role in the development of tumor, but also is a potential treasure for searching new ways to treat tumor. In this review, we summarized polysaccharides' regulation effects on tumor microenvironment progression and tried to give a new theoretical basis for the exploitation of polysaccharides with anti-tumor activity.
authors.affiliation: a State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Liqiao
authors.initials: L
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Shaoping
authors.initials: S
authors.lastname: Nie
authors.affiliation: a State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Mingyong
authors.initials: M
authors.lastname: Xie
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy; D011134:Polysaccharides / Q000494:pharmacology*; D059016:Tumor Microenvironment / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D011134:Polysaccharides
keywords: Polysaccharide; immunological therapy; tumor microenvironment