title: [Extrathymic Differentiation of αβT Lymphocytes].
abstract: Extrathymic differentiation is an alternative way of αβT lymphocyte development. In normal conditions it is expressed slightly and limited mainly to the liver and intestinal mucous. However, it increases significantly with age, as well as in certain physiological and pathological conditions, buying more widespread. In the review, the phenotypical and functional features of extrathymic T lymphocytes have been considered in detail depending on their localization and a way of the process activation. The mechanisms of such differentiation induction have been analyzed. Special attention is paid to the biological significance of extrathymic αβT cell development.
authors.forename: E M
authors.initials: EM
authors.lastname: Kuklina
authors.forename: N S
authors.initials: NS
authors.lastname: Glebezdina
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology / Q000502:physiology; D008099:Liver / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D008213:Lymphocyte Activation / Q000502:physiology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D014599:Uterus / Q000276:immunology / Q000378:metabolism / Q000502:physiology
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta