title: Association of Renal Function and Menopausal Status with Bone Mineral Density in Middle-aged Women.
abstract: The association between mild renal dysfunction and bone mineral density (BMD) has not been fully explored. It is also unclear how menopausal status and the use of Chinese herb affect this association. This is a cross-sectional study that included a total of 1,419 women aged 40 to 55 years old who were recruited from the MJ Health Management Institution in Taiwan between 2009 and 2010. Spinal BMD was assessed by dual-energy X-ray absorptiometry. Renal function was assessed using estimated glomerular filtration rate (eGFR) and creatinine clearance rate (CCr). The multivariable logistic regression and general linear models were employed to assess the association between renal function and BMD. Stratification analyses were performed by menopausal status and use of Chinese herbs. Low CCr levels were significantly associated with low BMD [adjusted odds ratio (AOR) = 1.48, 95% confidence interval (CI) = 1.15-1.90]. This association was observed in premenopausal women (AOR = 1.43, 95% CI = 1.07-1.92) and in women not taking Chinese herbs (AOR = 1.48, 95% CI = 1.14-1.94). CCr is a better predictor for low BMD in middle-aged women. Menopausal status and the use of Chinese herbs also affected this association.
authors.affiliation: Department of Family Medicine, Renai Branch, Taipei City Hospital, Taipei, Taiwan.|Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Yueh-Hsuan
authors.initials: YH
authors.lastname: Sheng
authors.affiliation: Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Jen-Hau
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Institute of Statistical Science Academia Sinica, Taipei, Taiwan.
authors.forename: Jeng-Min
authors.initials: JM
authors.lastname: Chiou
authors.affiliation: Department of Internal Medicine and Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Keh-Sung
authors.initials: KS
authors.lastname: Tsai
authors.affiliation: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Yue-Yuan
authors.initials: YY
authors.lastname: Lee
authors.affiliation: MJ Health Management Institution, Taipei, Taiwan.
authors.forename: Chwen-Keng
authors.initials: CK
authors.lastname: Tsao
authors.affiliation: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.|Department of Public Health, Taipei, Taiwan.|Research Center for Genes, Environment and Human Health, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Yen-Ching
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000328:Adult; D015519:Bone Density / Q000187:drug effects; D003404:Creatinine; D003430:Cross-Sectional Studies; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology*; D007677:Kidney Function Tests; D008593:Menopause; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D062486:Public Health Surveillance; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D004365:Drugs, Chinese Herbal; D003404:Creatinine