title: Clinical Approach to Diffuse Blisters.
abstract: Some blistering eruptions are self-limited, but others are life threatening, and prompt diagnosis and management are critical. The clinical presentation of vesicles and bullae suggests a broad differential and this article (1) highlights some common diagnoses that may be encountered by primary care physicians and subspecialists; (2) provides a possible systematic diagnostic approach to such patients, including history, physical examination, and relevant work-up.
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, 1520 3rd Avenue South, EFH 414, Birmingham, AL 35294-0009, USA.
authors.forename: Tarannum
authors.initials: T
authors.lastname: Jaleel
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, 1520 3rd Avenue South, EFH 414, Birmingham, AL 35294-0009, USA.
authors.forename: Young
authors.initials: Y
authors.lastname: Kwak
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, 1520 3rd Avenue South, EFH 414, Birmingham, AL 35294-0009, USA. Electronic address: nsami@uab.edu.
authors.forename: Naveed
authors.initials: N
authors.lastname: Sami
mesh_terms: D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D008487:Medical History Taking; D010808:Physical Examination; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy
keywords: Autoimmune bullous disorders; Blisters; Bullous drug eruptions; Diffuse blisters; Vesicles; Vesiculobullous