title: Use of rivaroxaban for the effective management of disseminated intravascular coagulation associated with abdominal aortic aneurysm.
abstract: A 67-year-old man with non-valvular atrial fibrillation (AF) and previous myocardial and cerebral infarctions had uncontrollable bleeding after undergoing dental extraction because of an exacerbation of chronic disseminated intravascular coagulation (DIC) due to an abdominal aortic aneurysm. After successful treatment of the bleeding with the transfusion of fresh frozen plasma and platelets, nafamostat mesilate was used to treat the chronic DIC. Finally, rivaroxaban (an oral direct Factor Xa inhibitor) was prescribed for chronic DIC, as well as non-valvular AF. Following the initiation of rivaroxaban, the chronic DIC gradually improved, and the patient was discharged.
authors.affiliation: Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawano
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hata
authors.forename: Akiko
authors.initials: A
authors.lastname: Uda
authors.forename: Koji
authors.initials: K
authors.lastname: Maemura
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D017544:Aortic Aneurysm, Abdominal / Q000150:complications*; D001550:Benzamidines; D001792:Blood Platelets; D001803:Blood Transfusion; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000188:drug therapy*; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D008297:Male; D000069552:Rivaroxaban / Q000627:therapeutic use*; D014081:Tooth Extraction
chemical_list: D000925:Anticoagulants; D001550:Benzamidines; D006146:Guanidines; D000069552:Rivaroxaban; C032855:nafamostat