title: CD73: A potential biomarker for anti-PD-1 therapy.
abstract: In our recent study, we show that tumoral CD73 expression limits the efficacy of anti-PD-1 therapy, and this is rescued by concomitant A2Ablockade. Since CD73 is known to be overexpressed in several human cancers and A2Aantagonists have undergone clinical trials for Parkinson's Disease, this combination warrants further investigation.
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre ; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Clayton, Australia.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Beavis
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre ; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Clayton, Australia.
authors.forename: Clare Y
authors.initials: CY
authors.lastname: Slaney
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre ; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Clayton, Australia.
authors.forename: Nicole
authors.initials: N
authors.lastname: Milenkovski
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre ; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Clayton, Australia.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Henderson
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre ; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Clayton, Australia.
authors.forename: Sherene
authors.initials: S
authors.lastname: Loi
authors.affiliation: Department of Immunology; Monash University ; Clayton, Australia ; Centre de Recherche du Centre Hospitalier de l'Université de Montréal; Faculté de Pharmacie et Institut du Cancer de Montréal ; Montréal, QC Canada.
authors.forename: John
authors.initials: J
authors.lastname: Stagg
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre ; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Clayton, Australia ; Department of Pathology; University of Melbourne ; Parkville, Australia.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Kershaw
authors.affiliation: Cancer Immunology Program; Peter MacCallum Cancer Centre ; East Melbourne, VIC Australia ; Sir Peter MacCallum Department of Oncology; The University of Melbourne ; Parkville, Australia ; Department of Immunology; Monash University ; Clayton, Australia ; Department of Pathology; University of Melbourne ; Parkville, Australia.
authors.forename: Phillip K
authors.initials: PK
authors.lastname: Darcy
keywords: CD73; adenosine; anti-PD-1; cancer; immunotherapy