title: Role of IL-17 Variants in Preeclampsia in Chinese Han Women.
abstract: Previous studies have suggested an important role for IL-17, mainly secreted by Th17 cells, in the development of systemic inflammation in preeclampsia (PE). This study therefore investigated the association between genetic variants in IL-17A, IL-17F, and IL-17RA and susceptibility to PE in Chinese Han women. We recruited 1,031 PE patients and 1,298 controls of later pregnant women, and used TaqMan allelic discrimination real-time PCR to genotype the polymorphisms of IL17A rs2275913, IL-17F rs763780, and IL-17RA rs4819554. No significant differences in genotypic or allelic frequencies were found at all three polymorphic sites between PE patients and controls (rs2275913: genotype χ2 = 0.218, p = 0.897 and allele χ2 = 0.157, p = 0.692, OR = 1.024, 95%CI 0.911-1.152; rs763780: genotype χ2 = 1.948, p = 0.377 and allele χ2 = 1.242, p = 0.265, OR = 0.897, 95%CI 0.741-1.086; rs4819554: genotype χ2 = 0.633, p = 0.729 and allele χ2 = 0.115, p = 0.735, OR = 1.020, 95%CI 0.908-1.146). There were also no significant differences in genetic distributions between mild/severe PE or early/late-onset PE and control subgroups. Our data indicate that the genetic variants of rs2275913 in IL-17A, rs763780 in IL-17F, and rs4819554 in IL-17RA may not play a role in the pathogenesis of PE in Chinese Han women. However, these findings should be confirmed in other ethnic populations.
authors.affiliation: Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Mingzhen
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Blood Transfusion, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Liu
authors.affiliation: Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Wang
authors.affiliation: Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Pathogenic Microorganisms, the Medical College of Qingdao University, Qingdao, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ji
authors.affiliation: Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Yuanhua
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Clinical Laboratory, Qingdao Municipal Hospital (Group), Qingdao, China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Song
authors.affiliation: Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D053722:Receptors, Interleukin-17 / Q000235:genetics* / Q000378:metabolism
chemical_list: C109985:IL17RA protein, human; D020381:Interleukin-17; D020033:Protein Isoforms; D053722:Receptors, Interleukin-17