title: Immediate Adjuvant Radiation Therapy Following Radical Prostatectomy Should Not Be Advised for Men with Extraprostatic Extension Who Have Negative Surgical Margins.
abstract: Although three large randomized prospective clinical trials have demonstrated that postoperative radiotherapy in patients with adverse pathological features reduces prostate-specific antigen recurrence and may decrease clinical failure, this approach has not gained widespread acceptance, likely because the data strongly support such an approach only in men with Gleason ≥7 with positive surgical margins.
authors.affiliation: James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address: pwalsh@jhmi.edu.
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Walsh
authors.affiliation: University of Melbourne, Department of Surgery and Olivia Newton-John Cancer Research Institute, Austin Hospital and Peter MacCallum Cancer Centre, Melbourne, Australia.
authors.forename: Nathan
authors.initials: N
authors.lastname: Lawrentschuk
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D018365:Neoplasm, Residual; D018579:Patient Selection; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors
chemical_list: D017430:Prostate-Specific Antigen