title: Association of serum omentin levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: a hospital-based study.
abstract: BACKGROUND
  Whereas a few studies have reported associations of serum omentin levels with subclinical atherosclerosis in patients with diabetes, little information is available with respect to the associations of serum omentin levels and diabetic microvascular complications. The aim of this study was to investigate the relationships of serum omentin levels and vascular complications including cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  We recruited 97 patients who evaluated complications of diabetes. CAN was assessed by five standard cardiovascular reflex tests according to Ewing's protocol. Diabetic nephropathy (DN), retinopathy (DR), and peripheral neuropathy (DPN) were evaluated. Serum omentin levels were assessed by ELISA. Atherosclerotic burden was evaluated by measuring the brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI).
  
  
  RESULTS
  The prevalence of CAN increased borderline significantly across the omentin tertiles (p = 0.05) and CAN point increased significantly and progressively across the omentin tertiles (p = 0.013). The prevalence of other microvascular complications (DPN, DN, and DR) did not differ among omentin tertiles. The mean levels of baPWV also increased significantly and progressively across the omentin tertiles (p = 0.002). Serum omentin levels were significantly positively correlated with CAN point (p = 0.004) and borderline significantly correlated with baPWV (p = 0.05) after multivariate adjustment. Regarding linear regression analysis for CAN point, univariate regression analysis demonstrated that CAN point associated with omentin, diastolic blood pressure (DBP) and hsCRP. Multiple regression analysis revealed that omentin levels, together DBP and baPWV correlated with CAN point. This present study suggests that serum omentin levels may be independently associate with CAN in patients with T2DM.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, #170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-767, Republic of Korea. chanh@schmc.ac.kr.
authors.forename: Chan-Hee
authors.initials: CH
authors.lastname: Jung
authors.affiliation: Department of Obstetrics and Gynecology, Cha University School of Medicine, Bundang, Korea. aa2346@chamc.co.kr.
authors.forename: Sang-Hee
authors.initials: SH
authors.lastname: Jung
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, #170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-767, Republic of Korea. byby815@schmc.ac.kr.
authors.forename: Bo-Yeon
authors.initials: BY
authors.lastname: Kim
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, #170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-767, Republic of Korea. chkimem@schmc.ac.kr.
authors.forename: Chul-Hee
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, #170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-767, Republic of Korea. dmkang7003@schmc.ac.kr.
authors.forename: Sung-Koo
authors.initials: SK
authors.lastname: Kang
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, #170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 420-767, Republic of Korea. hanna@schmc.ac.kr.
authors.forename: Ji-Oh
authors.initials: JO
authors.lastname: Mok
mesh_terms: D000368:Aged; D000419:Albuminuria; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications; D001342:Autonomic Nervous System Diseases / Q000097:blood* / Q000209:etiology; D001794:Blood Pressure; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003928:Diabetic Nephropathies / Q000209:etiology / Q000652:urine; D003929:Diabetic Neuropathies / Q000097:blood* / Q000209:etiology; D003930:Diabetic Retinopathy / Q000209:etiology; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006339:Heart Rate; D006801:Humans; D037102:Lectins / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D063177:Pulse Wave Analysis; D014636:Valsalva Maneuver
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins