title: Antioedematogenic activity, acetylcholinesterase inhibition and antimicrobial properties of Jacaranda oxyphylla.
abstract: Jacaranda oxyphylla Cham. (Bignoniaceae) is a shrub found in the Brazilian cerrado and used in folk medicine to treat microbial infections. The aim of this study was to carry out a phytochemical screening and evaluate antioedematogenic, antimicrobial and antiacetylcholinesterase properties of J. oxyphylla crude extracts. All extracts analysed showed presence of terpenoids, which are potentially active chemical substances. A high AChE inhibitory activity for hexane extract from leaves and for the extracts from twigs was found. Ethanol extract from leaves of J. oxyphylla showed activity against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli) bacteria. This extract was also effective in inhibiting the stages of inflammation evaluated. Biological investigation and phytochemical screening of J. oxyphylla extracts provided additional evidence of its traditional medicinal value.
authors.affiliation: a Departamento de Química , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.|b Faculdade de Farmácia , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.
authors.forename: V V
authors.initials: VV
authors.lastname: Pereira
authors.affiliation: c Departamento de Química , Universidade Federal dos Vales do Jequitinhonha e Mucuri , Diamantina , Brazil.
authors.forename: R R
authors.initials: RR
authors.lastname: Silva
authors.affiliation: d Departamento de Química , Universidade Federal de Viçosa , Viçosa , Brazil.
authors.forename: M H
authors.initials: MH
authors.lastname: Dos Santos
authors.affiliation: e Laboratório de Fitoquímica e Química Medicinal , Universidade Federal de Alfenas , Alfenas , Brazil.
authors.forename: D F
authors.initials: DF
authors.lastname: Dias
authors.affiliation: e Laboratório de Fitoquímica e Química Medicinal , Universidade Federal de Alfenas , Alfenas , Brazil.
authors.forename: M E C
authors.initials: ME
authors.lastname: Moreira
authors.affiliation: a Departamento de Química , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.
authors.forename: J A
authors.initials: JA
authors.lastname: Takahashi
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects; D029402:Bignoniaceae / Q000737:chemistry*; D001938:Brazil; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy*; D004926:Escherichia coli / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy; D008519:Medicine, Traditional; D064209:Phytochemicals / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D064209:Phytochemicals; D010936:Plant Extracts; D013729:Terpenes
keywords: AChE inhibition; Bignoniaceae; Jacaranda oxyphylla; anti-inflammatory; antibacterial activity