title: Evaluating the relationship between reelin gene variants (rs7341475 and rs262355) and schizophrenia: A meta-analysis.
abstract: Studies have suggested that reelin (RELN) polymorphism was associated with the susceptibility of schizophrenia (SZ), but the results remained controversial. Thus, we conducted this meta-analysis to determine whether RELN variants (rs7341475 and rs262355) were associated with SZ risk. Studies were identified through retrieving Web of Science, PubMed and Embase databases from inception to May 2015. The genotype data were extracted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). For rs7341475, five studies with 4741 SZ patients and 10075 controls are included and the results indicate that carriage of A allele is associated with decreased SZ risk in dominant genetic model (OR=0.90, 95%CI=0.83-0.98) and additive model (OR=0.90, 95% CI=0.84-0.97). Subgroup analysis indicates that the association between rs7341475 and SZ is only significant in Caucasian. For rs262355, four studies with 2017 SZ patients and 3274 controls are included, the results demonstrate that carriage of A allele is associated with increased risk of SZ only in Caucasian (dominant model: OR=1.17, 95%CI=1.01-1.37; additive model OR=1.13, 95%CI=1.02-1.27). This meta-analysis suggests that rs7341475 (A/G) and rs262355 (A/T) polymorphisms in RELN gene are inversely associated with SZ risk.
authors.affiliation: Alzheimer's Disease and Related Disorders Center & Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Neurology, Shaanxi Provincial People's Hospital, Xi'an 710061, Shaanxi, China.
authors.forename: Xingzhi
authors.initials: X
authors.lastname: Guo
authors.affiliation: Alzheimer's Disease and Related Disorders Center & Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China. Electronic address: xiaoshifu@msn.com.
authors.forename: Shifu
authors.initials: S
authors.lastname: Xiao
mesh_terms: D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D000091042:Reelin Protein; D012306:Risk; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human; D012697:Serine Endopeptidases
keywords: Meta-analysis; Polymorphism; Reelin; Risk; Schizophrenia