title: Scavenger receptors and non-coding RNAs: relevance in atherogenesis.
abstract: Scavenger receptors (SRs), which recognize modified low-density lipoprotein (LDL) by oxidation or acetylation, are a group of receptors on plasma membrane of macrophages and other cell types. These receptors by facilitating modified LDL uptake are a primary step in the intracellular accumulation of modified LDL and formation of fatty streak. Non-coding RNAs (ncRNAs) are a group of functional RNA nucleotides that are not translated into protein, and include microRNAs (miRs), snoRNAs, siRNAs, snRNAs, exRNAs, piRNAs, and the long ncRNAs (lncRNAs). Recently, ncRNAs have received much attention due to their effects in a variety of disease states such as atherosclerotic cardiovascular disease and cancers. A host of ncRNAs, such as miRs and lncRNAs, have been found to be involved in the regulation of SRs and the inflammatory cascade and subsequently atherosclerosis. Here, we review this important area to create interest in this growing field among researchers and clinicians alike.
authors.affiliation: Department of Internal Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People's Republic of China Department of Medicine, Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA daiyaoh@163.com mehtajl@uams.edu.
authors.forename: Yao
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Humanitas Clinical and Research Center, Rozzano (MI), Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Condorelli
authors.affiliation: Department of Medicine, Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA daiyaoh@163.com mehtajl@uams.edu.
authors.forename: Jawahar L
authors.initials: JL
authors.lastname: Mehta
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology*; D006801:Humans; D022661:RNA, Untranslated / Q000502:physiology*; D051116:Receptors, Scavenger / Q000145:classification / Q000502:physiology*
chemical_list: D022661:RNA, Untranslated; D051116:Receptors, Scavenger
keywords: Atherogenesis; Non-coding RNA; Scavenger receptor