title: Suicidal behaviour in first-episode non-affective psychosis: Specific risk periods and stage-related factors.
abstract: Suicide is a major cause of premature death in psychosis. Earlier stages have been associated with higher risk. However, such risk periods have not been specifically determined and risk factors for suicidal behaviour may change over those periods, which may have crucial implications for suicide prevention. The aim of this study was to determine and characterize the highest risk period for suicide in a representative sample of first-episode psychosis (FEP) patients. Suicidal behaviour prior to first presentation of psychosis and during a 3-year follow-up was examined in a sample of 397 individuals. Risk factors for suicidal behaviour during specific time periods were investigated and compared. The greatest suicide risk was found during the month before and 2 months after first contact with psychiatric services (i.e., 'early' attempts). Severity of depressive symptoms and cannabis use emerged as predominant risk factors across time. 'Early' attempters were characterized as being male, living in urban areas, having poor premorbid adjustment, requiring hospitalization, scoring higher on anxiety measures and unusual thought content than non-attempters. Greater suspiciousness and more severe depressive symptoms distinguished the 'late' attempters. In conclusion, there is a specific high risk period for suicide in FEP around the time of the first presentation. Early intervention programmes targeting phase-specific risk factors, particularly psychotic symptoms management and secondary depression prevention strategies may be useful for suicide prevention in psychosis.
authors.affiliation: Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL. School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain; Department of Psychosis Studies, Institute of Psychiatry, King׳s College London, London, UK. Electronic address: rayesa@humv.es.
authors.forename: Rosa
authors.initials: R
authors.lastname: Ayesa-Arriola
authors.affiliation: Department of Psychiatry, Elche General University Hospital, Alicante, Spain.
authors.forename: Elisa García
authors.initials: EG
authors.lastname: Alcaraz
authors.affiliation: Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL. School of Medicine, University of Cantabria, Santander, Spain.
authors.forename: Begoña Vicente
authors.initials: BV
authors.lastname: Hernández
authors.affiliation: Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL. School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain; Department of Psychosis Studies, Institute of Psychiatry, King׳s College London, London, UK.
authors.forename: Rocío
authors.initials: R
authors.lastname: Pérez-Iglesias
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, King׳s College London, London, UK.
authors.forename: Javier David
authors.initials: JD
authors.lastname: López Moríñigo
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, King׳s College London, London, UK.
authors.forename: Rina
authors.initials: R
authors.lastname: Duta
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, King׳s College London, London, UK.
authors.forename: Anthony S
authors.initials: AS
authors.lastname: David
authors.affiliation: CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain; Department of Medicine, University of Valencia, Biomedical Research Institute INCLIVA, Valencia, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Tabares-Seisdedos
authors.affiliation: Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL. School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain.
authors.forename: Benedicto
authors.initials: B
authors.lastname: Crespo-Facorro
mesh_terms: D000293:Adolescent; D000328:Adult; D003071:Cognition / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications* / Q000453:epidemiology*; D012044:Regression Analysis; D016728:Self-Injurious Behavior / Q000453:epidemiology / Q000209:etiology*; D013405:Suicide / Q000706:statistics & numerical data*; D016019:Survival Analysis; D055815:Young Adult
keywords: First episode psychosis; Schizophrenia; Suicide attempt