title: Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis.
abstract: We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.
authors.affiliation: Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Pakistan.
authors.forename: Kiran I
authors.initials: KI
authors.lastname: Masood
authors.affiliation: Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Pervez
authors.affiliation: Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Rottenberg
authors.affiliation: Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Pakistan.
authors.forename: Beena
authors.initials: B
authors.lastname: Umar
authors.affiliation: Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Pakistan. Electronic address: zahra.hasan@aku.edu.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Hasan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006099:Granuloma / Q000382:microbiology; D006801:Humans; D018655:Lymphocyte Count; D008264:Macrophages / Q000276:immunology; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D009336:Necrosis / Q000473:pathology*; D054367:Receptors, CXCR3 / Q000378:metabolism*; D000071222:Suppressor of Cytokine Signaling 1 Protein / Q000378:metabolism*; D000071223:Suppressor of Cytokine Signaling 3 Protein / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology; D014388:Tuberculosis, Lymph Node / Q000473:pathology*; D055815:Young Adult
chemical_list: C515187:CXCR3 protein, human; D054367:Receptors, CXCR3; C108944:SOCS1 protein, human; C106644:SOCS3 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein
keywords: caseous necrosis; granuloma; suppressor of cytokine signaling-1; tuberculous lymphadenitis