title: Reproductive and lifestyle risk factors and mammographic density in Mexican women.
abstract: OBJECTIVE
  Several breast cancer risk factors have been consistently associated with mammographic density (MD); however, data are limited for Hispanic women.
  
  
  METHODS
  We examined data from 1007 premenopausal and 600 postmenopausal women in the Mexican Teachers' Cohort. Multivariable linear regression was used to estimate associations between risk factors and MD.
  
  
  RESULTS
  Among premenopausal women, age, current body mass index (BMI), BMI at age 18 years, and weight change since age 18 years were inversely associated with percent MD, whereas benign breast disease, alcohol intake, and breastfeeding 12 months or more were associated with higher percent MD. Among postmenopausal women, age, current BMI, BMI at age 18 years, weight change since age 18 years, and speaking or having parents who speak an indigenous language were inversely associated with percent MD, whereas benign breast disease and greater age at natural menopause were positively associated with percent MD. Other breast cancer risk factors, such as age at menarche, parity, and age at first pregnancy, were not significantly associated with density in either premenopausal or postmenopausal women.
  
  
  CONCLUSIONS
  Results from the Mexican Teachers' Cohort are generally consistent with predictors of mammographic density observed in primarily non-Hispanic white populations; however, certain risk factors (e.g., parity) were not significantly associated with MD.
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
authors.forename: Megan S
authors.initials: MS
authors.lastname: Rice
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Bertrand
authors.affiliation: Center for Research on Population Health, National Institute of Public Health, Mexico; Center for Research in Epidemiology and Population Health (CESP), Inserm (Institut National de la Santé et de la Recherche Médicale), U1018, Villejuif, France; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address: mlajous@insp.mx.
authors.forename: Martin
authors.initials: M
authors.lastname: Lajous
authors.affiliation: Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
authors.forename: Rulla M
authors.initials: RM
authors.lastname: Tamimi
authors.affiliation: Center for Research on Population Health, National Institute of Public Health, Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Torres
authors.affiliation: Center for Research on Population Health, National Institute of Public Health, Mexico.
authors.forename: Ruy
authors.initials: R
authors.lastname: López-Ridaura
authors.affiliation: Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieu
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D001940:Breast / Q000473:pathology* / Q000502:physiology; D000071060:Breast Density; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000208:ethnology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008019:Life Style; D042361:Mammary Glands, Human / Q000002:abnormalities*; D008327:Mammography; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015999:Multivariate Analysis; D010298:Parity; D017698:Postmenopause; D011247:Pregnancy; D017697:Premenopause; D017584:Reproductive History; D012307:Risk Factors
keywords: Breast cancer; Mammographic density; Mexico