title: Comparison of pregnancy rates in beef cattle after a fixed-time AI with once- or twice-used controlled internal drug release devices.
abstract: The use of fixed-time artificial insemination (FTAI) provides producers with numerous benefits including the use of superior genetics, shorter breeding and calving seasons, and a more uniform calf crop. However, the cost of implementing FTAI protocols is one of the several drawbacks hindering their use in the beef industry. Potential injection-site lesions from intramuscular injections of the hormones necessary for estrus synchronization are also a cause of concern for carcass quality. The objectives of this experiment were to (1) determine whether or not a twice-used controlled internal drug release (CIDR) device would be effective in an FTAI protocol without adversely affecting pregnancy rate and (2) whether or not the subcutaneous administration of PGF2α affects pregnancy rate. Nulliparous females (n = 99) between 13 and 27 months of age and multiparous cows (n = 43) between 48 and 74 months of age were synchronized for estrus using the 7-day CO-Synch + CIDR protocol. The females were randomly assigned to one of the two treatments: (1) a once-used CIDR (control) or (2) a twice-used CIDR device (treatment) incorporated into their synchronization protocol. The females were also randomly assigned to have their injection of PGF2α administered either intramuscularly or subcutaneously. Blood was taken in a random subset of nulliparous females (n = 52) just before device removal and assayed for concentration of progesterone. The concentration of progesterone was higher (P = 0.01) in the animals that received once-used CIDR devices than that in those received twice-used CIDR devices (3.4 ± 0.5 and 1.4 ± 0.5 ng/mL, respectively). There was no significant effect of parity (P = 0.82), artificial insemination technician (P = 0.60), PGF2α administration (P = 0.83), or treatment (P = 0.67) on pregnancy rates to artificial insemination which were 75.4 ± 6.0% and 71.7 ± 6.4%, for animals that received once- and twice-used CIDR devices, respectively. This study provides evidence that although concentration of progesterone is decreased in animals treated with a twice-used CIDR device, there is still a sufficient release of progesterone from the device to effectively synchronize estrus without adversely affecting the fertility of a herd.
authors.affiliation: Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Muth-Spurlock
authors.affiliation: Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: Poole
authors.affiliation: Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA. Electronic address: scott_whisnant@ncsu.edu.
authors.forename: C S
authors.initials: CS
authors.lastname: Whisnant
mesh_terms: D000818:Animals; D002417:Cattle / Q000502:physiology*; D015237:Dinoprost / Q000008:administration & dosage* / Q000009:adverse effects; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000662:veterinary*; D004973:Estrus Synchronization / Q000379:methods; D005260:Female; D063427:Food Quality; D015918:Infusion Pumps, Implantable; D007273:Injections, Intramuscular / Q000009:adverse effects; D007315:Insemination, Artificial / Q000379:methods / Q000662:veterinary*; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood; D000069466:Red Meat
chemical_list: D011374:Progesterone; D015237:Dinoprost
keywords: Artificial insemination; Beef cattle; Controlled internal drug release; Estrus synchronization