title: The Impact of Worsening Heart Failure in the United States.
abstract: In-hospital worsening heart failure represents a clinical scenario wherein a patient hospitalized for acute heart failure experiences a worsening of their condition, requiring escalation of therapy. Worsening heart failure is associated with worse in-hospital and postdischarge outcomes. Worsening heart failure is increasingly being used as an endpoint or combined endpoint in clinical trials, as it is unique to episodes of acute heart failure and captures an important event during the inpatient course. While prediction models have been developed to identify worsening heart failure, there are no known FDA-approved medications associated with decreased worsening heart failure. Continued study is warranted.
authors.affiliation: Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA. Electronic address: lauren.b.cooper@duke.edu.
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Cooper
authors.affiliation: Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA.
authors.forename: Adam D
authors.initials: AD
authors.lastname: DeVore
authors.affiliation: Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA.
authors.forename: G
authors.initials: G
authors.lastname: Michael Felker
mesh_terms: D000208:Acute Disease; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D006333:Heart Failure / Q000191:economics / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D012042:Registries; D014481:United States / Q000453:epidemiology
keywords: Clinical trials; Medications; Outcomes; Worsening heart failure