title: The voltage-gated sodium channel NaV 1.9 in visceral pain.
abstract: BACKGROUND
  Visceral pain is a common symptom for patients with gastrointestinal (GI) disease. It is unpleasant, debilitating, and represents a large unmet medical need for effective clinical treatments. Recent studies have identified NaV 1.9 as an important regulator of afferent sensitivity in visceral pain pathways to mechanical and inflammatory stimuli, suggesting that NaV 1.9 could represent an important therapeutic target for the treatment of visceral pain. This potential has been highlighted by the identification of patients who have an insensitivity to pain or painful neuropathies associated with mutations in SCN11A, the gene encoding voltage-gated sodium channel subtype 1.9 (NaV 1.9).
  
  
  OBJECTIVE
  Here, we address the role of NaV 1.9 in visceral pain and what known human NaV 1.9 mutants can tell us about NaV 1.9 function in gut physiology and pathophysiology.
authors.affiliation: Wingate Institute of Neurogastroenterology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|National Centre for Bowel Research and Surgical Innovation, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
authors.forename: J R F
authors.initials: JR
authors.lastname: Hockley
authors.affiliation: Neusentis (Pfizer Ltd.), Cambridge, UK.
authors.forename: W J
authors.initials: WJ
authors.lastname: Winchester
authors.affiliation: Wingate Institute of Neurogastroenterology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|National Centre for Bowel Research and Surgical Innovation, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Bulmer
mesh_terms: D000818:Animals; D006801:Humans; D062558:NAV1.9 Voltage-Gated Sodium Channel / Q000502:physiology*; D059265:Visceral Pain / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology
chemical_list: D062558:NAV1.9 Voltage-Gated Sodium Channel
keywords: NaV1.9; enteric nervous system; inflammatory bowel disease; irritable bowel syndrome; nociceptor sensitivity; visceral afferent; visceral pain; voltage-gated sodium channel