title: Recognizing off-target drug effects in the gut and brain: revisiting isotretinoin and depression.
abstract: Clinicians often face complex decisions regarding off-target drug effects, both in diagnosis and treatment. A key component in the formulation of the correct diagnosis is the temporal relationship between drug introduction and adverse effect. The sentinel injury may target the gut and brain. The description of the complaint may vary among providers. Modeling Information visualization for clinicians in real time will require the integration of time-stamped data with organ-specific complaints.
authors.affiliation: Department of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA.
authors.forename: R
authors.initials: R
authors.lastname: Kollipara
authors.affiliation: Department of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA.
authors.forename: C
authors.identifier: http://orcid.org/0000-0002-3346-6603
authors.initials: C
authors.lastname: Reisz
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000897:Anti-Ulcer Agents / Q000009:adverse effects; D001921:Brain / Q000187:drug effects*; D003866:Depressive Disorder / Q000139:chemically induced*; D003879:Dermatologic Agents / Q000009:adverse effects*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D008297:Male; D002189:Marijuana Abuse / Q000150:complications; D009853:Omeprazole / Q000009:adverse effects; D019338:Polypharmacy; D013270:Stomach / Q000187:drug effects*
chemical_list: D000897:Anti-Ulcer Agents; D003879:Dermatologic Agents; D015474:Isotretinoin; D009853:Omeprazole