title: HIV reverse transcriptase gene mutations in anti-retroviral treatment naïve rural people living with HIV/AIDS.
abstract: This study is designed to find out the mutational variations of reverse transcriptase (RT) gene of HIV, after the traditional drug usage among anti-retroviral therapy naïve rural people living with HIV/AIDS. HIV Reactive patients, who were exposed for indigenous medicines such as Siddha, Ayurveda etc., for a minimum period of 6 months were taken for this study. Among 40 patients, two samples (5.55%) demonstrated high-level mutational resistance variations for nucleoside RT inhibitor (NRTI) and non-NRTI. The predominant polymorphisms detected were K122E (91.7%), V60I (91.7%), V35T (89%), Q207E (89%), D177E (89%), T200A (86.1%), S48T (83.33%), K173A (80.6%).
authors.affiliation: Department of Microbiology, Sri Muthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu, India.
authors.forename: K
authors.initials: K
authors.lastname: Mohanakrishnan
authors.forename: A
authors.initials: A
authors.lastname: Kasthuri
authors.forename: S K
authors.initials: SK
authors.lastname: Amsavathani
authors.forename: G
authors.initials: G
authors.lastname: Sumathi
mesh_terms: D019943:Amino Acid Substitution; D005260:Female; D005787:Gene Frequency; D006678:HIV / Q000201:enzymology* / Q000302:isolation & purification; D015658:HIV Infections / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D012424:Rural Population
chemical_list: D054303:HIV Reverse Transcriptase