title: Incremental prognostic value of MRI in the staging of early cervical cancer: a prospective study and review of the literature.
abstract: This is to evaluate the predictive ability of clinical examination and preoperative magnetic resonance imaging (MRI) for the staging of early cervical cancer. We prospectively evaluated 115 patients with cervical cancer, International Federation of Gynecologic and Obstetrics (FIGO) stage <IIB; receiver operating characteristic (ROC) analysis determined the predictive ability of MRI, clinical assessment, and their combination for tumor staging. Surgery was the standard of reference. MRI was more accurate than clinical examination for tumor estimate, parametrial or internal os involvement. When combined with MRI, the predictive ability of clinical examination for overall staging [area under the curve (AUC)=0.59, P>.05) increased significantly (AUC=0.84, P<.05). Our results support the official incorporation of MRI into FIGO classification system.
authors.affiliation: Department of Radiology, Aretaieion Hospital, Medical School, University of Athens, 76 Vas. Sofias Ave., Athens, Greece, 11528. Electronic address: charisbourgioti@yahoo.com.
authors.forename: Charis
authors.initials: C
authors.lastname: Bourgioti
authors.affiliation: Department of Radiology, Aretaieion Hospital, Medical School, University of Athens, 76 Vas. Sofias Ave., Athens, Greece, 11528. Electronic address: kchatoupis@yahoo.gr.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Chatoupis
authors.affiliation: 1st Department of Obstetrics and Gynecology, Gynecologic Oncology Unit, Alexandra Hospital, Medical School, University of Athens, 80 Vas. Sofias Ave., Greece, 11528. Electronic address: arodolakis@med.uoa.gr.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Rodolakis
authors.affiliation: Department of Radiology, Aretaieion Hospital, Medical School, University of Athens, 76 Vas. Sofias Ave., Athens, Greece, 11528. Electronic address: aantoniou@med.uoa.gr.
authors.forename: Aristeidis
authors.initials: A
authors.lastname: Antoniou
authors.affiliation: Department of Health, Epidemiology and Medical Statistics, Medical School, University of Athens, 25 Alexandroupoleos Str., Athens, Greece, 11527. Electronic address: htzavara@med.uoa.gr.
authors.forename: Chara
authors.initials: C
authors.lastname: Tzavara
authors.affiliation: Department of Radiology, Aretaieion Hospital, Medical School, University of Athens, 76 Vas. Sofias Ave., Athens, Greece, 11528. Electronic address: vkout1968@yahoo.gr.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Koutoulidis
authors.affiliation: Department of Radiology, Aretaieion Hospital, Medical School, University of Athens, 76 Vas. Sofias Ave., Athens, Greece, 11528. Electronic address: lia.angela1312@gmail.com.
authors.forename: Lia Angela
authors.initials: LA
authors.lastname: Moulopoulos
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
keywords: Cervical cancer; Cervix uteri; Magnetic resonance imaging; tumor staging