title: Investigating the associations between polymorphisms in the NTRK2 and NGFR genes and completed suicide in the Slovenian sample.
abstract: OBJECTIVE
  The most abundant neurotrophin in the mammalian brain is brain-derived neurotrophic factor (BDNF), which acts through binding to neurotrophic tyrosine kinase receptor type 2 (NTRK2) and to nerve growth factor receptor (NGFR). Our previous work showed an association of the single nucleotide polymorphism (SNP) rs6265 in the BDNF gene with completed suicide in the Slavic population. Therefore, we extended the investigation to the SNPs within NTRK2 and NGFR genes and searched for associations with the completed suicide phenotype.
  
  
  METHODS
  In 775 Caucasian individuals, namely, 486 suicide completers and 289 controls, we performed genotyping of five SNPs within the NTRK2 (rs11140714, rs1147198, rs1187323, rs10780691, and rs10868235) and six SNPs within the NGFR (rs2072446, rs7219709, rs7224806, rs734194, rs741071, and rs741072) genes.
  
  
  RESULTS
  We did not find evidence for an association of the SNPs studied with the phenotype either on the single marker or on the haplotype level.
  
  
  CONCLUSIONS
  To our knowledge, this is the first study that has examined SNPs in the NTRK2 and NGFR genes for associations with the completed suicide phenotype. However, our findings suggest that these SNPs may not be associated particularly with completed suicide in Slovenia, although they might have a relevant informative value as the study has been carried out on a sample from a population that has one of the highest suicide rates in the world.
authors.affiliation: aInstitute of Biochemistry bInstitute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Ropret
authors.forename: Tomaž
authors.initials: T
authors.lastname: Zupanc
authors.forename: Radovan
authors.initials: R
authors.lastname: Komel
authors.forename: Alja
authors.initials: A
authors.lastname: Videtič Paska
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D020813:Receptor, trkB; D017475:Receptors, Nerve Growth Factor / Q000235:genetics*; D017524:Slovenia / Q000453:epidemiology; D013405:Suicide / Q000706:statistics & numerical data*; D044465:White People / Q000235:genetics*
chemical_list: D008562:Membrane Glycoproteins; C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; C000591259:tropomyosin-related kinase-B, human