title: [Clinical features and prognosis in MLL-AF10 positive acute leukemia].
abstract: OBJECTIVE
  To analyze the clinical features and prognosis of acute leukemia patients with the mixed lineage leukemia（MLL）gene rearrangements AF10 positive.
  
  
  METHODS
  6 cases with MLL-AF10 positive were analyzed retrospectively, related literatures were reviewed to clarify MLL-AF10 patients'clinical features and prognosis.
  
  
  RESULTS
  The median age of 6 cases was 19.5 years old, 5 patients with fever onset, the onset white blood cells of 4 patients were less than 10×10⁹/L. 5 cases were as M₅ and 1 case M₄ according to FAB classification, the level of fusion gene（RQ-PCR）was 0.23%-22.60% when diagnosed, 4 cases had concomitant WT1 gene mutation, flow cytometry disclosed myeloid phenotype. Of 5 evaluated patients achieved the first complete remission after conventional chemotherapy, 2 cases of complex karyotype died, one case died of sepsis in induction, another died from failing of transplantation. 4 out of 5 transplant recipients gained long term survival.
  
  
  CONCLUSIONS
  The MLL-AF10 positive patients were mostly young men, the majority FAB classification was M5 or M4, often onset with fever, low white blood cells and low level of fusion gene, usually associated with WT1 mutation. Conventional chemotherapy produced a high response rate, but easy to relapse, while the complex karyotype had a poor prognosis, allo-HSCT may have the potential to improve the prognosis of MLL-AF10 positive patients.
authors.affiliation: Peking University People's Hospital, Beijing 100044 , China.
authors.forename: Li'na
authors.initials: L
authors.lastname: Wang
authors.affiliation: Peking University People's Hospital, Beijing 100044 , China.
authors.forename: Yazhen
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Peking University People's Hospital, Beijing 100044 , China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Jia
authors.affiliation: Peking University People's Hospital, Beijing 100044 , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Peking University People's Hospital, Beijing 100044 , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Peking University People's Hospital, Beijing 100044 , China.
authors.forename: Shenmiao
authors.initials: S
authors.lastname: Yang
authors.affiliation: Peking University People's Hospital, Beijing 100044 , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wen
authors.affiliation: Peking University People's Hospital, Beijing 100044 , China.
authors.forename: Jin
authors.initials: J
authors.lastname: Lu
authors.affiliation: Peking University People's Hospital, Beijing 100044 , China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Huang
mesh_terms: D000208:Acute Disease; D002880:Chromosomes, Human, Pair 11; D005260:Female; D005434:Flow Cytometry; D015321:Gene Rearrangement; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011379:Prognosis; D011519:Proto-Oncogenes; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D051788:Myeloid-Lymphoid Leukemia Protein