title: Protein intake and lean body mass preservation during energy intake restriction in overweight older adults.
abstract: BACKGROUND
  Dietary-induced weight loss is generally accompanied by a decline in skeletal muscle mass. The loss of muscle mass leads to a decline in muscle strength and impairs physical performance. A high dietary protein intake has been suggested to allow muscle mass preservation during energy intake restriction.
  
  
  OBJECTIVE
  To investigate the impact of increasing dietary protein intake on lean body mass, strength and physical performance during 12 weeks of energy intake restriction in overweight older adults.
  
  
  METHODS
  Sixty-one overweight and obese men and women (63±5 years) were randomly assigned to either a high protein diet (HP; 1.7 g kg(-1) per day; n=31) or normal protein diet (NP; 0.9 g kg(-1) per day; n=30) during a 12-week 25% energy intake restriction. During this controlled dietary intervention, 90% of the diet was provided by the university. At baseline and after the intervention, body weight, lean body mass (dual-energy X-ray absorptiometry), leg strength (1-repetition maximum), physical performance (Short Physical Performance Battery, 400 m) and habitual physical activity (actigraph) were assessed.
  
  
  RESULTS
  Body weight declined in both groups with no differences between the HP and NP groups (-8.9±2.9 versus -9.1±3.4 kg, respectively; P=0.584). Lean body mass declined by 1.8±2.2 and 2.1±1.4 kg, respectively, with no significant differences between groups (P=0.213). Leg strength had decreased during the intervention by 8.8±14.0 and 8.9±12.8 kg, with no differences between groups (P=0.689). Physical performance as measured by 400 m walking speed improved in both groups, with no differences between groups (P=0.219).
  
  
  CONCLUSIONS
  Increasing protein intake above habitual intake levels (0.9 g kg(-1) per day) does not preserve lean body mass, strength or physical performance during prolonged energy intake restriction in overweight older adults.
authors.affiliation: Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.|Top Institute Food and Nutrition, Wageningen, The Netherlands.
authors.forename: E M P
authors.initials: EM
authors.lastname: Backx
authors.affiliation: Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.|Top Institute Food and Nutrition, Wageningen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Tieland
authors.affiliation: Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
authors.forename: K J
authors.initials: KJ
authors.lastname: Borgonjen-van den Berg
authors.affiliation: Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
authors.forename: P R
authors.initials: PR
authors.lastname: Claessen
authors.affiliation: Top Institute Food and Nutrition, Wageningen, The Netherlands.|NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: L J C
authors.initials: LJ
authors.lastname: van Loon
authors.affiliation: Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.|Top Institute Food and Nutrition, Wageningen, The Netherlands.
authors.forename: L C P G M
authors.initials: LC
authors.lastname: de Groot
mesh_terms: D001823:Body Composition; D015992:Body Mass Index; D004038:Diet, Reducing / Q000009:adverse effects / Q000379:methods; D004044:Dietary Proteins; D002149:Energy Intake; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D050177:Overweight / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D004044:Dietary Proteins