title: Hemoglobin-Based Nanoarchitectonic Assemblies as Oxygen Carriers.
abstract: Safe and effective artificial oxygen carriers are the subject of great interest due to the problems of traditional blood transfusion and enormous demand in clinical use. In view of its unique oxygen-transport ability and normal metabolic pathways, hemoglobin is regarded as an ideal oxygen-carrying unit. With advances in nano-biotechnology, hemoglobin assemblies as artificial oxygen carriers achieve great development. Here, recent progress on hemoglobin-based oxygen carriers is highlighted in view of two aspects: acellular hemoglobin-based oxygen carriers and cellular hemoglobin-based oxygen carriers. These novel oxygen carriers exhibit advantages over traditional carriers and will greatly promote research on reliable and feasible oxygen carriers.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Northwest Institute of Nuclear Technology, Xi'an, Shaanxi, 710024, China.
authors.forename: Li
authors.initials: L
authors.lastname: Duan
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D004912:Erythrocytes / Q000378:metabolism; D005978:Glutathione / Q000737:chemistry; D006454:Hemoglobins / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010100:Oxygen / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D000975:Antioxidants; D003432:Cross-Linking Reagents; D006454:Hemoglobins; D012709:Serum Albumin; D012997:Solvents; D000255:Adenosine Triphosphate; D005978:Glutathione; D010100:Oxygen
keywords: hemoglobin; layer-by-layer assembly; nanoarchitectonics; oxygen carriers