title: Adenocarcinoma of the cervical esophagus arising from ectopic   gastric mucosa: report of two cases and review of the literature.
abstract: Esophageal adenocarcinoma arising from ectopic gastric mucosa (EGM) is extremely rare. We describe here two Japanese patients with adenocarcinoma of the cervical esophagus arising from EGM. Case 1 is a 62-year-old man who had slightly red EGM in the cervical esophagus on upper gastrointestinal endoscopy (UGE). Because the biopsy showed atypical glands that were suspicious for adenocarcinoma, endoscopic submucosal dissection was performed. Histopathological examination revealed that the lesion was a well-differentiated adenocarcinoma (pT1a MM). Lymphovascular invasion was absent, and the margins were free from carcinoma. Case 2 is a 57-year-old man who had an elevated lesion with a bleeding tendency in an area of EGM in the cervical esophagus on UGE. Adenocarcinoma was diagnosed in the biopsy. Because of the presence of enlarged lymph nodes (#106recL), preoperative chemoradiotherapy was performed to reduce the size of the adenocarcinoma and lymph nodes prior to resection of the cervical esophagus and reconstruction with free jejunal grafts. Histopathological examination revealed moderately differentiated adenocarcinoma (0-I, pT2N1M0, pStage II). In both cases, adenocarcinoma was surrounded by EGM, which led to the diagnosis of EGM-derived esophageal adenocarcinoma. Here, we report its immunohistochemical characteristics in the present cases and discuss the histogenesis.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Nomura
authors.forename: Toshiro
authors.initials: T
authors.lastname: Iizuka
authors.forename: Naoko
authors.initials: N
authors.lastname: Inoshita
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Kuribayashi
authors.forename: Takahito
authors.initials: T
authors.lastname: Toba
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yamada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamashita
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Furuhata
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kikuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Matsui
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Mitani
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
authors.forename: Shu
authors.initials: S
authors.lastname: Hoteya
authors.forename: Masaki
authors.initials: M
authors.lastname: Ueno
authors.forename: Harushi
authors.initials: H
authors.lastname: Udagawa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kaise
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D001706:Biopsy; D002828:Choristoma / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007583:Jejunum / Q000637:transplantation; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC / Q000378:metabolism; D055272:Mucin-6 / Q000378:metabolism; D009367:Neoplasm Staging
chemical_list: C524678:MUC5AC protein, human; C524734:MUC6 protein, human; D055271:Mucin 5AC; D055272:Mucin-6