title: Plasma phospholipid arachidonic acid and lignoceric acid are associated with the risk of cardioembolic stroke.
abstract: Cardioembolic (CE) stroke is the most severe subtype of ischemic stroke with high recurrence and mortality. However, there is still little information on the association of plasma fatty acid (FA) with CE stroke. The objective of this study was to test the hypothesis whether the composition of plasma phospholipid FA is associated with the risk of CE stroke. The study subjects were collected from the Korea University Stroke Registry. Twenty-one subjects were selected as CE stroke group, and 39 age- and sex-matched subjects with non-CE stroke were selected as controls. Sociodemographic factors, clinical measurements, and plasma phospholipid FA compositions were compared between the groups. Logistic regression was used to obtain estimates of the associations between the relevant FAs and CE stroke. The result showed that the CE stroke group had higher levels of free FA and lower levels of triglycerides before and after adjustment (all P < .05). In the regression analysis, elaidic acid (18:1Tn9) and arachidonic acid (20:4n6) were positively related, but lignoceric acid (24:0) was negatively related to CE stroke in all constructed models (all P < .05). In conclusion, plasma phospholipid FA composition was associated with CE stroke risk in Korean population, with higher proportions of elaidic acid and arachidonic acid and lower proportion of lignoceric acid in CE stroke.
authors.affiliation: Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul 120-749, Republic of Korea.
authors.forename: Hye-Kyung
authors.initials: HK
authors.lastname: Chung
authors.affiliation: Department of Food and Nutrition, Korea University, Seoul 136-701, Republic of Korea; Department of Public Health Sciences, Graduate School, Korea University, Seoul 136-701, Republic of Korea.
authors.forename: Yoonsu
authors.initials: Y
authors.lastname: Cho
authors.affiliation: Department of Food and Nutrition, Korea University, Seoul 136-701, Republic of Korea.
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Do
authors.affiliation: Department of Neurology, College of Medicine, Korea University Guro Hospital, Korea University, Seoul 152-703, Republic of Korea.
authors.forename: Kyungmi
authors.initials: K
authors.lastname: Oh
authors.affiliation: Department of Neurology, College of Medicine, Korea University Guro Hospital, Korea University, Seoul 152-703, Republic of Korea. Electronic address: nukseo@korea.ac.kr.
authors.forename: Woo-Keun
authors.initials: WK
authors.lastname: Seo
authors.affiliation: Department of Food and Nutrition, Korea University, Seoul 136-701, Republic of Korea; Department of Public Health Sciences, Graduate School, Korea University, Seoul 136-701, Republic of Korea. Electronic address: mjshin@korea.ac.kr.
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Shin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016718:Arachidonic Acid / Q000097:blood*; D002545:Brain Ischemia / Q000097:blood*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D020521:Stroke / Q000097:blood*
chemical_list: D005227:Fatty Acids; D016718:Arachidonic Acid; C010210:lignoceric acid
keywords: Arachidonic acid; Cardioembolic stroke; Fatty acid; Lignoceric acid; Trans-fat