title: [Wnt signalling pathway and cervical cancer].
abstract: Cervical cancer (CC) is a pathology that arises in the cervical epithelium, whose major cause of risk is human papillomavirus (HPV) infection. Due to the fact that HPV infection per se is not enough to generate a carcinogenic process, it has been proposed that alterations in the Wnt signaling pathway are involved in cervical carcinogenesis. The Wnt family consists of 13 receptors and 19 ligands, and it is highly conserved phylogenetically due to its contribution in different biological processes, such as embryogenesis and tissue regeneration. Additionally, this signaling pathway modulates various cellular functions, for instance: cell proliferation, differentiation, migration and cell polarity. This paper describes the Wnt signaling pathways and alterations that have been found in members of this family in different cancer types and, especially, in CC.
authors.affiliation: Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. adry.aguilar.lemarroy@gmail.com.
authors.forename: Moisés
authors.initials: M
authors.lastname: Ramos-Solano
authors.forename: Monserrat
authors.initials: M
authors.lastname: Álvarez-Zavala
authors.forename: Beatriz
authors.initials: B
authors.lastname: García-Castro
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Jave-Suárez
authors.forename: Adriana
authors.initials: A
authors.lastname: Aguilar-Lemarroy
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D063646:Carcinogenesis / Q000378:metabolism*; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000503:physiopathology / Q000821:virology; D060449:Wnt Signaling Pathway
chemical_list: D014408:Biomarkers, Tumor
keywords: Cervical intraepithelial neoplasia; Papilloma; Wnt receptors