title: MiR-506 suppresses cell proliferation and tumor growth by targeting Rho-associated protein kinase 1 in hepatocellular carcinoma.
abstract: Recent studies have shown that miR-506 plays important roles in human cancer progression. However, little is known about the function of miR-506 in hepatocellular carcinoma (HCC). In this study, we found that miR-506 significantly inhibits HCC cell proliferation in vitro and tumorigenicity in vivo. Moreover, miR-506 induced G1/S cell cycle arrest and apoptosis in HCC cells. Rho-associated protein kinase 1(ROCK1) was identified as a novel target of miR-506; overexpression of ROCK1 reversed the suppressive effects of miR-506 in HCC cells. Additionally, ROCK1 was found up-regulated and inversely correlated with miR-506 in HCC tissues. Therefore, our findings collectively suggest that miR-506 acts as a tumor suppressor via regulation of ROCK1 expression and may thus be a promising therapeutic target for HCC.
authors.affiliation: Departments of Gastroenterology, Affiliated Hospital of Logistics University of the Chinese People's Armed Police Forces, Tianjin 300162, China. Electronic address: quanjun_d@126.com.
authors.forename: Quanjun
authors.initials: Q
authors.lastname: Deng
authors.affiliation: Departments of Gastroenterology, Affiliated Hospital of Logistics University of the Chinese People's Armed Police Forces, Tianjin 300162, China.
authors.forename: Liqun
authors.initials: L
authors.lastname: Xie
authors.affiliation: Departments of Gastroenterology, Affiliated Hospital of Logistics University of the Chinese People's Armed Police Forces, Tianjin 300162, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
mesh_terms: D063646:Carcinogenesis; D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000473:pathology*; D049109:Cell Proliferation / Q000502:physiology*; D016147:Genes, Tumor Suppressor; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology / Q000473:pathology*; D035683:MicroRNAs / Q000502:physiology*; D054460:rho-Associated Kinases / Q000378:metabolism*
chemical_list: C561508:MIRN506 microRNA, human; D035683:MicroRNAs; C515851:ROCK1 protein, human; D054460:rho-Associated Kinases
keywords: Hepatocellular carcinoma; ROCK1; Tumor suppressor; miR-506