title: Efficacy and safety of miconazole for oral candidiasis: a systematic review and meta-analysis.
abstract: The objective of this study is to assess the efficacy and safety of miconazole for treating oral candidiasis. Twelve electronic databases were searched for randomized controlled trials evaluating treatments for oral candidiasis and complemented by hand searching. The clinical and mycological outcomes, as well as adverse effects, were set as the primary outcome criteria. Seventeen trials were included in this review. Most studies were considered to have a high or moderate level of bias. Miconazole was more effective than nystatin for thrush. For HIV-infected patients, there was no significant difference in the efficacy between miconazole and other antifungals. For denture wearers, microwave therapy was significantly better than miconazole. No significant difference was found in the safety evaluation between miconazole and other treatments. The relapse rate of miconazole oral gel may be lower than that of other formulations. This systematic review and meta-analysis indicated that miconazole may be an optional choice for thrush. Microwave therapy could be an effective adjunct treatment for denture stomatitis. Miconazole oral gel may be more effective than other formulations with regard to long-term results. However, future studies that are adequately powered, large-scale, and well-designed are needed to provide higher-quality evidence for the management of oral candidiasis.
authors.affiliation: Department of Oral Medicine, Peking University School and Hospital of Stomatology, Haidian District, Beijing, China.
authors.forename: L-W
authors.initials: LW
authors.lastname: Zhang
authors.affiliation: Department of stomatology, Peking University International Hospital, Changping District, Beijing, China.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Fu
authors.affiliation: Department of Oral Medicine, Peking University School and Hospital of Stomatology, Haidian District, Beijing, China.
authors.forename: H
authors.initials: H
authors.lastname: Hua
authors.affiliation: Department of Oral Medicine, Peking University School and Hospital of Stomatology, Haidian District, Beijing, China.
authors.forename: Z-M
authors.initials: ZM
authors.lastname: Yan
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000532:radiotherapy; D002638:Chewing Gum; D005782:Gels; D006801:Humans; D008825:Miconazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008872:Microwaves / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D002638:Chewing Gum; D005782:Gels; D008825:Miconazole
keywords: meta-analysis; miconazole; oral candidiasis; systematic review