title: [Research of Hippophae rhamnoides fruits on serum lipids and liver protection effects in high-fat-diet rats].
abstract: OBJECTIVE
  To study the effects o Hippophae rhamnoides fruits on serum lipids and liver protection in high-fat-diet rats.
  
  
  METHODS
  Wistar rats were divided into 5 groups,including control group, high lipid model group and Hippophae rhamnoides low-, medium- and high- dose groups,every group wastaken high-fat diet except control group. The rats in control group and high lipid group were lavaged with physiological saline. The doses of Hippophae rhamnoides in low, middle and high groups were determined based on the 1x, 5x, and 10x standard human doses (50 g/60 kg BW), respectively. The rat were orally given test sample respectively for 28 days, once a day. Observed the changes of serum lipids and hepatic tissues pathology.
  
  
  RESULTS
  Compared with the control group, the serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) were increased significantly (P < 0.05) in high-fat-diet rats. Compared with the high lipid group, Hippophae rhamnoides of different doses could significantly reduce the content of TG (P < 0.01). Hippophae rhamnoides reduced the tendency of TC and LDL-C in serum and reduced the fatty degeneration of liver cells.
  
  
  CONCLUSIONS
  The Hippophae rhamnoides fruits can reduce the level of serum lipids and prevent the occurrence of fatty liver, can be used for the prevention of hyperlipidemia.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Song
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Ge
mesh_terms: D000818:Animals; D002784:Cholesterol; D008078:Cholesterol, LDL; D059305:Diet, High-Fat / Q000009:adverse effects*; D005234:Fatty Liver / Q000097:blood / Q000517:prevention & control*; D005638:Fruit / Q000737:chemistry*; D031281:Hippophae / Q000009:adverse effects / Q000737:chemistry*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides
chemical_list: D008078:Cholesterol, LDL; D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol