title: Clickable Nucleic Acids: Sequence-Controlled Periodic Copolymer/Oligomer Synthesis by Orthogonal Thiol-X Reactions.
abstract: Synthetic polymer approaches generally lack the ability to control the primary sequence, with sequence control referred to as the holy grail. Two click chemistry reactions were now combined to form nucleobase-containing sequence-controlled polymers in simple polymerization reactions. Two distinct approaches are used to form these click nucleic acid (CNA) polymers. These approaches employ thiol-ene and thiol-Michael reactions to form homopolymers of a single nucleobase (e.g., poly(A)n ) or homopolymers of specific repeating nucleobase sequences (e.g., poly(ATC)n). Furthermore, the incorporation of monofunctional thiol-terminated polymers into the polymerization system enables the preparation of multiblock copolymers in a single reaction vessel; the length of the diblock copolymer can be tuned by the stoichiometric ratio and/or the monomer functionality. These polymers are also used for organogel formation where complementary CNA-based polymers form reversible crosslinks.
authors.affiliation: Department of Chemical & Biological Engineering, University of Colorado Boulder, 596 UCB, Boulder, Colorado 80309-0596 (USA).
authors.forename: Weixian
authors.initials: W
authors.lastname: Xi
authors.affiliation: Department of Chemical & Biological Engineering, University of Colorado Boulder, 596 UCB, Boulder, Colorado 80309-0596 (USA).
authors.forename: Sankha
authors.initials: S
authors.lastname: Pattanayak
authors.affiliation: Department of Chemical & Biological Engineering, University of Colorado Boulder, 596 UCB, Boulder, Colorado 80309-0596 (USA).
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Chemical & Biological Engineering, University of Colorado Boulder, 596 UCB, Boulder, Colorado 80309-0596 (USA).
authors.forename: Benjamin
authors.initials: B
authors.lastname: Fairbanks
authors.affiliation: Department of Chemical & Biological Engineering, University of Colorado Boulder, 596 UCB, Boulder, Colorado 80309-0596 (USA).
authors.forename: Tao
authors.initials: T
authors.lastname: Gong
authors.affiliation: Department of Chemical & Biological Engineering, University of Colorado Boulder, 596 UCB, Boulder, Colorado 80309-0596 (USA).
authors.forename: Justine
authors.initials: J
authors.lastname: Wagner
authors.affiliation: Department of Materials Science & Engineering and Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, Delaware 19716 (USA).
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Kloxin
authors.affiliation: Department of Chemical & Biological Engineering, University of Colorado Boulder, 596 UCB, Boulder, Colorado 80309-0596 (USA). Christopher.Bowman@Colorado.edu.
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Bowman
mesh_terms: D057930:Click Chemistry; D009696:Nucleic Acids / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids; D011108:Polymers; D013438:Sulfhydryl Compounds
keywords: block copolymers; click chemistry; polymerization; thiols