title: Presurgical Psychological and Neuroendocrine Predictors of Psychiatric Morbidity After Major Vascular Surgery: A Prospective Longitudinal Study.
abstract: OBJECTIVE
  Major life stressors, including major surgeries, are often followed by psychiatric symptoms and disorders. Prior retrospective work found abdominal aortic aneurysm (AAA) repair is followed by increased psychiatric morbidity, which may adversely influence physical and functional recovery. Identifying risk factors before surgery, such as dysregulation in stress response systems, might be useful in improving preventative intervention.
  
  
  METHODS
  Two hundred sixteen patients receiving open AAA or aortofemoral bypass surgeries, endovascular AAA repair, or nonsurgical AAA treatment were recruited from two vascular surgery services. Psychiatric symptoms and salivary cortisol measures (waking, 4 PM, and 11 PM, before and after low-dose dexamethasone) were obtained at intake and 3- and 9-month follow-ups.
  
  
  RESULTS
  After open surgeries, 18% of patients had new psychiatric disorders, compared with 4% of patients receiving endovascular AAA repair or nonsurgical treatment (odds ratio = 6.0, 95% confidence interval = 1.6-22.1, p = .007). Having a history of major depression predicted the onset of new disorders in surgical patients. Presurgical cortisol levels were associated with both baseline (r = 0.23, p < .05) and 9-month (r = 0.32, p < .01) psychiatric symptoms (cortisol B = 1.0, standard error = 0.48, p < .05, in repeated-measures mixed model).
  
  
  CONCLUSIONS
  Open AAA repair surgery is prospectively linked to the development of psychiatric morbidity, and history of depression elevates risk. Cortisol measures before surgery are associated with current and future psychological functioning, suggesting potential neurobiological mechanisms that may contribute to vulnerability. These results can help identify surgical patients at risk and point to potential targets for risk reduction interventions.
authors.affiliation: From the Mental Health Service (King, Liberzon), Ann Arbor VA Healthcare Systems; Departments of Psychiatry (King, Abelson, Gholami, Liberzon) and Surgery (Henke), University of Michigan, Ann Arbor, Michigan; Department of Surgery (Upchurch), University of Virginia, Charlottesville, Virginia; and Department of Surgery (Graham), The Cleveland Clinic, Cleveland, Ohio.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: King
authors.forename: James L
authors.initials: JL
authors.lastname: Abelson
authors.forename: Bardia
authors.initials: B
authors.lastname: Gholami
authors.forename: Gilbert R
authors.initials: GR
authors.lastname: Upchurch
authors.forename: Peter
authors.initials: P
authors.lastname: Henke
authors.forename: Linda
authors.initials: L
authors.lastname: Graham
authors.forename: Israel
authors.initials: I
authors.lastname: Liberzon
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000523:psychology; D001008:Anxiety Disorders / Q000209:etiology*; D001012:Aorta, Abdominal / Q000601:surgery*; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000523:psychology* / Q000601:surgery; D003866:Depressive Disorder / Q000097:blood / Q000150:complications*; D003907:Dexamethasone / Q000494:pharmacology; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis* / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000150:complications / Q000523:psychology* / Q000601:surgery; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011183:Postoperative Complications / Q000453:epidemiology* / Q000523:psychology; D011300:Preoperative Care; D011446:Prospective Studies; D012306:Risk; D012307:Risk Factors; D012463:Saliva / Q000737:chemistry; D057566:Self Report; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology*; D014656:Vascular Surgical Procedures / Q000523:psychology*
chemical_list: D003907:Dexamethasone; D006854:Hydrocortisone