title: Long-term survival in gliosarcoma with radiation-induced meningeal sarcomas: Case report and molecular features.
abstract: Gliosarcoma is a rare primary malignant tumor of the central nervous system with poor prognosis. The median survival time of this disease ranges from 6 months to 14.8 months. However, a computer literature search indicated few long-term survivors. We investigated a case of a survivor of gliosarcoma with radiation-induced meningeal sarcomas, who showed no indication of recurrence for more than 9 years. A battery of molecular studies was performed to develop a molecular profile of this unique patient. We also reviewed the distinct clinical and molecular features of the tumor.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Qing-Tao
authors.initials: QT
authors.lastname: Kong
authors.forename: Xin-Hu
authors.initials: XH
authors.lastname: Wu
authors.affiliation: Department of Radiation Oncology, Jinling Hosp, Nanjing Univ Sch Med, Nanjing, China.
authors.forename: Xi-Xu
authors.initials: XX
authors.lastname: Zhu
mesh_terms: D000328:Adult; D015254:DNA Modification Methylases; D045643:DNA Repair Enzymes; D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D018316:Gliosarcoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000235:genetics / Q000473:pathology*; D051059:PTEN Phosphohydrolase / Q000096:biosynthesis; D011859:Radiography; D016896:Treatment Outcome; D025521:Tumor Suppressor Proteins
chemical_list: D025521:Tumor Suppressor Proteins; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D045643:DNA Repair Enzymes