title: Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders.
abstract: The role of the fibroblast growth factor (FGF) system in brain-related disorders has received considerable attention in recent years. To understand the role of this system in neurological and psychiatric disorders, it is important to identify the specific members of the FGF family that are implicated, their location and the various mechanisms they can be modulated. Each disorder appears to impact specific molecular players in unique anatomical locations, and all of these could conceivably become targets for treatment. In the last several years, the issue of how to target this system directly has become an area of increasing interest. To date, the most promising therapeutics are small molecule inhibitors and antibodies that modulate FGF receptor (FGFR) function. Beyond attempting to modify the primary players affected by a given brain disorder, it may prove useful to target molecules, such as membrane-bound or extracellular proteins that interact with FGF ligands or FGFRs to modulate signaling.
authors.affiliation: Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA. Electronic address: caturner@umich.edu.
authors.forename: Cortney A
authors.initials: CA
authors.lastname: Turner
authors.affiliation: Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Eren-Koçak
authors.affiliation: Sagient Research, San Diego, CA, USA.
authors.forename: Edny G
authors.initials: EG
authors.lastname: Inui
authors.affiliation: Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Watson
authors.affiliation: Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Huda
authors.initials: H
authors.lastname: Akil
mesh_terms: D000818:Animals; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009422:Nervous System Diseases / Q000378:metabolism*; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors
keywords: Brain; Development; Hippocampus; Neurological; Psychiatric; Therapeutics