title: Improvement of mechanical properties of pellet containing tablets by thermal treatment.
abstract: Batches of partially spray-dried lactose tablets with three different initial tensile strength (∼20N, ∼35N, ∼50N) were made. Changes along a 24h long thermal treatment at 100°C in tensile strength, friability, individual mass, water content, disintegration time, average free volume and wetting properties were evaluated. Caffeine containing gastroresistant pellets were gained by drug layering and filmcoating of inert microcrystalline cellulose pellet cores in fluid bed equipment. Shape, size, mechanical properties, drug content and dissolution profile of the coated pellets were determined. Batches of pellet containing tablets with three different pellet-filler ratios were compressed where partially spray-dried lactose was used as a filler-binder material.Characteristics of pellet containing tablets were evaluated before and after a 24h long thermal treatment at 100°C. Results shown that the poor initial mechanical properties (friability, tensile strength) were improved by thermal exposure while there were no remarkable alterations in drug release profiles.
authors.affiliation: Formulation R&D, Gedeon Richter Plc., Gyömrői Str. 19-21, H-1103 Budapest, Hungary; Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7-9, H-1092 Budapest, Hungary.
authors.forename: Zsombor
authors.initials: Z
authors.lastname: Csobán
authors.affiliation: Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7-9, H-1092 Budapest, Hungary.
authors.forename: Barnabás
authors.initials: B
authors.lastname: Kállai-Szabó
authors.affiliation: Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7-9, H-1092 Budapest, Hungary.
authors.forename: Nikolett
authors.initials: N
authors.lastname: Kállai-Szabó
authors.affiliation: University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. Str. 7-9, H-1092 Budapest, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Sebe
authors.affiliation: Department of Electronics Technology, Budapest University of Technology and Economics, Egry J. Str. 18, H-1111 Budapest, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Gordon
authors.affiliation: Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7-9, H-1092 Budapest, Hungary. Electronic address: antal.istvan@pharma.semmelweis-univ.hu.
authors.forename: István
authors.initials: I
authors.lastname: Antal
mesh_terms: D007785:Lactose / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical; D013718:Tensile Strength
chemical_list: D013607:Tablets; D007785:Lactose
keywords: Dissolution profile; Multiple-unit pellet system (MUPS); Reduced friability; Spray-dried lactose; Tablet hardness; Thermal treatment