title: Genetic investigation of multicentric glioblastoma multiforme: case report.
abstract: The authors report a case of multicentric glioblastoma multiforme (GBM) in which all 4 tumor foci were resected and evaluated using both comparative genomic hybridization array and RNA sequencing. Genetic analysis showed that the tumors shared a common origin, although each had its own unique set of genetic aberrations. The authors note that the genetic heterogeneity of multicentric GBM likely contributes to the failures of current treatments. The case underscores the necessity of increased genetic investigation.
authors.affiliation: Michigan State University College of Medicine, Grand Rapids, Michigan;|Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute;
authors.forename: Brett
authors.initials: B
authors.lastname: Schroeder
authors.affiliation: Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute;
authors.forename: Nameeta
authors.initials: N
authors.lastname: Shah
authors.affiliation: CellNetix Pathology & Laboratories, Seattle; and.
authors.forename: Steve
authors.initials: S
authors.lastname: Rostad
authors.affiliation: Department of Radiology, Radia Inc., Everett, Washington.
authors.forename: Brendan
authors.initials: B
authors.lastname: McCullough
authors.affiliation: Department of Radiology, Radia Inc., Everett, Washington.
authors.forename: Brian
authors.initials: B
authors.lastname: Aguedan
authors.affiliation: Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute;
authors.forename: Greg
authors.initials: G
authors.lastname: Foltz
authors.affiliation: Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute;
authors.forename: Charles
authors.initials: C
authors.lastname: Cobbs
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D055028:Comparative Genomic Hybridization; D003399:Craniotomy; D018740:Genetic Heterogeneity; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000601:surgery
keywords: CGH = comparative genomic hybridization; CGH array; DCE = dynamic contrast enhancement; GBM; GBM = glioblastoma multiforme; RNA-sequencing; brain tumor; multicentric; oncology; rCBV = relative cerebral blood volume