title: Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents.
abstract: On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Sahu
authors.affiliation: College of Pharmacy, Ewha Womans University , Seoul 120-750, Korea.
authors.forename: Tamima
authors.initials: T
authors.lastname: Umme
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors.forename: Jinha
authors.initials: J
authors.lastname: Yu
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.|College of Pharmacy, Ewha Womans University , Seoul 120-750, Korea.
authors.forename: Akshata
authors.initials: A
authors.lastname: Nayak
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors.forename: Gyudong
authors.initials: G
authors.lastname: Kim
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors.forename: Minsoo
authors.initials: M
authors.lastname: Noh
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors.forename: Dae-Duk
authors.initials: DD
authors.lastname: Kim
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D015774:Ganciclovir / Q000031:analogs & derivatives* / Q000494:pharmacology; D006558:Herpes Genitalis / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D016566:Organoselenium Compounds / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D016566:Organoselenium Compounds; D015774:Ganciclovir; D000212:Acyclovir