title: Molecular basis of the regulation of iron homeostasis in fission and filamentous yeasts.
abstract: When iron load exceeds that needed by fission and filamentous yeasts, iron-regulatory GATA-type transcription factors repress genes encoding iron acquisition systems. In contrast, under iron starvation, optimization of cellular iron utilization is coordinated by a specialized regulatory subunit of the CCAAT-binding factor that fosters repression of genes encoding iron-using proteins. Despite these findings, there is still limited knowledge concerning the mechanisms by which these iron-responsive regulators respond to high- or low-iron availability. To provide a framework for understanding common and distinct properties of iron-dependent transcriptional regulators, a repertoire of their functional domains in different fungal species is presented here. In addition, discovery of interacting partners of these iron-responsive factors contributes to provide additional insight into their properties.
authors.affiliation: Département de Biochimie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Ariane
authors.initials: A
authors.lastname: Brault
authors.affiliation: Département de Biochimie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Thierry
authors.initials: T
authors.lastname: Mourer
authors.affiliation: Département de Biochimie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Labbé
mesh_terms: D000595:Amino Acid Sequence; D017124:Conserved Sequence; D005656:Fungal Proteins / Q000737:chemistry / Q000502:physiology; D050980:GATA Transcription Factors / Q000737:chemistry / Q000502:physiology; D015966:Gene Expression Regulation, Fungal; D006706:Homeostasis; D007501:Iron / Q000378:metabolism*; D003904:Mitosporic Fungi / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D005656:Fungal Proteins; D050980:GATA Transcription Factors; D007501:Iron
keywords: fungal iron-dependent CCAAT-binding factors; iron-regulatory GATA-type transcription factors; iron-sparing response; regulation of iron acquisition