title: Levofloxacin susceptibility testing against Helicobacter pylori: evaluation of a modified disk diffusion method compared to E test.
abstract: We compared levofloxacin (1 μg/disk) disk diffusion method to E test against 212 Helicobacter pylori strains. Using diameter breakpoints for susceptibility (≥15 mm) and resistance (≤9 mm), very major error, major error rate, and categoric agreement were 0.0%, 0.6%, and 93.9%, respectively. The method may be useful in low-resource laboratories.
authors.affiliation: Department of Medical Microbiology, Medical University of Sofia, Zdrave Street 2, 1431, Sofia, Bulgaria. Electronic address: l.boyanova@hotmail.com.
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Boyanova
authors.affiliation: Department of Health Economics, Faculty of Public Health-Medical University of Sofia, 8, "Byalo more" str., Sofia, Bulgaria.
authors.forename: Juliana
authors.initials: J
authors.lastname: Ilieva
authors.affiliation: Department of Medical Microbiology, Medical University of Sofia, Zdrave Street 2, 1431, Sofia, Bulgaria.
authors.forename: Galina
authors.initials: G
authors.lastname: Gergova
authors.affiliation: Department of Medical Microbiology, Medical University of Sofia, Zdrave Street 2, 1431, Sofia, Bulgaria.
authors.forename: Ivan
authors.initials: I
authors.lastname: Mitov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D052978:Disk Diffusion Antimicrobial Tests / Q000379:methods*; D005260:Female; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D064704:Levofloxacin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin
keywords: Disk diffusion; E test; Helicobacter pylori; Levofloxacin; Susceptibility testing