title: Of Brains and Blood: Developmental Origins of Glioma Diversity?
abstract: The multiple cell types of brain and blood arise from pluripotent stem cells via progressively more committed downstream progenitors. In this issue of Cancer Cell, Alcantara Llaguno and colleagues show that identical genetic drivers give rise to distinct glioma subtypes within differentially committed neural progenitors-a paradigm well established for leukemias.
authors.affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors.forename: Mariella G
authors.initials: MG
authors.lastname: Filbin
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: charles_stiles@dfci.harvard.edu.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Stiles
mesh_terms: D053687:Adult Stem Cells / Q000473:pathology*; D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology*; D002490:Central Nervous System / Q000166:cytology*; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology*; D006801:Humans