title: Nanopublications for exposing experimental data in the life-sciences: a Huntington's Disease case study.
abstract: Data from high throughput experiments often produce far more results than can ever appear in the main text or tables of a single research article. In these cases, the majority of new associations are often archived either as supplemental information in an arbitrary format or in publisher-independent databases that can be difficult to find. These data are not only lost from scientific discourse, but are also elusive to automated search, retrieval and processing. Here, we use the nanopublication model to make scientific assertions that were concluded from a workflow analysis of Huntington's Disease data machine-readable, interoperable, and citable. We followed the nanopublication guidelines to semantically model our assertions as well as their provenance metadata and authorship. We demonstrate interoperability by linking nanopublication provenance to the Research Object model. These results indicate that nanopublications can provide an incentive for researchers to expose data that is interoperable and machine-readable for future use and preservation for which they can get credits for their effort. Nanopublications can have a leading role into hypotheses generation offering opportunities to produce large-scale data integration.
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Eleni
authors.initials: E
authors.lastname: Mina
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Mark
authors.initials: M
authors.lastname: Thompson
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Rajaram
authors.initials: R
authors.lastname: Kaliyaperumal
authors.affiliation: Department of Zoology, University of Oxford, Oxford, UK.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: van Eelke
authors.initials: vE
authors.lastname: der Horst
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Zuotian
authors.initials: Z
authors.lastname: Tatum
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Hettne
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Erik A
authors.initials: EA
authors.lastname: Schultes
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Barend
authors.initials: B
authors.lastname: Mons
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Marco
authors.initials: M
authors.lastname: Roos
keywords: Data integration; Huntington’s disease; Interoperability; Nanopublication; Provenance; Research object; Workflows