title: Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a neurodegenerative disease with broad impact. Although Aβ and tau have been proposed as the key molecules in the disease mechanism, comprehensive understanding of AD pathogenesis requires a systemic view at the genomic level. From studies on the brain transcriptome of AD, we have gradually realized the contribution of the immune system to AD development. Recent explorations on the blood transcriptome of AD patients have revealed robust immune activation in the peripheral blood. The combination of transcriptome studies and other types of studies has further elucidated the roles of specific immune pathways in distinct cell types during AD development and highlighted the critical contributions from immune genes such as TREM2.
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Fuhai
authors.initials: F
authors.lastname: Song
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Qian
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Peng
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Guangchun
authors.initials: G
authors.lastname: Han
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Zhouxian
authors.initials: Z
authors.lastname: Bai
authors.affiliation: Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Australia.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Crack
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. Electronic address: leihx@big.ac.cn.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Lei
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology*; D000818:Animals; D001253:Astrocytes / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology; D017628:Microglia / Q000276:immunology; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology; D059467:Transcriptome
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human