title: Current use and perspective of indocyanine green clearance in liver diseases.
abstract: Indocyanine green (ICG) is a water-soluble anionic compound that binds to plasma proteins after intravenous administration. It is selectively taken up at the first pass by hepatocytes and excreted unchanged into the bile. With the development of ICG elimination measurement by spectrophotometry, the ICG retention test has become a safe, rapid, reproducible, inexpensive and noninvasive tool for the assessment of liver function. Clinical evidence suggests that the ICG retention test can enable the establishment of tailored management strategies by providing prognostic information. In particular, this method has been evaluated as a prognostic marker in patients with advanced cirrhosis or awaiting liver transplantation. In addition, it is used as a marker of portal hypertension in cirrhotic patients, as a prognostic factor in intensive care units and for the assessment of liver function in patients undergoing liver surgery. Since recent technology enables ICG-PDR to be measured noninvasively at the bedside, this parameter is an attractive addition to liver function and regional haemodynamic monitoring. However, the current state-of-the-art as concerns this technology remains at a low level of evidence and thorough assessment is required.
authors.affiliation: AP-HP, Hôpital Henri-Mondor, Service d'Anesthésie et des Réanimations Chirurgicales, 94000 Créteil, France. Electronic address: eric.levesque@hmn.aphp.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Levesque
authors.affiliation: AP-HP, Hôpital Henri-Mondor, Service d'Anesthésie et des Réanimations Chirurgicales, 94000 Créteil, France.
authors.forename: Eléonore
authors.initials: E
authors.lastname: Martin
authors.affiliation: AP-HP, Hôpital Henri-Mondor, Service d'Anesthésie et des Réanimations Chirurgicales, 94000 Créteil, France.
authors.forename: Daniela
authors.initials: D
authors.lastname: Dudau
authors.affiliation: AP-HP, Hôpital Henri-Mondor, Service de Chirurgie Digestive, Hépatobiliaire, Pancréatique et Transplantation Hépatique, 94000 Créteil, France.
authors.forename: Chetana
authors.initials: C
authors.lastname: Lim
authors.affiliation: AP-HP, Hôpital Henri-Mondor, Service d'Anesthésie et des Réanimations Chirurgicales, 94000 Créteil, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Dhonneur
authors.affiliation: AP-HP, Hôpital Henri-Mondor, Service de Chirurgie Digestive, Hépatobiliaire, Pancréatique et Transplantation Hépatique, 94000 Créteil, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Azoulay
mesh_terms: D004396:Coloring Agents / Q000493:pharmacokinetics*; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008107:Liver Diseases / Q000175:diagnosis* / Q000378:metabolism*; D008111:Liver Function Tests / Q000379:methods*; D011182:Postoperative Care
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green
keywords: Indocyanine green clearance; Liver; Liver function