title: Foundational dendritic processing that is independent of the cell type-specific structure in model primary neurons.
abstract: It has long been known that primary neurons in the brain and spinal cord exhibit very distinctive dendritic structures. However, it remains unclear whether dendritic processing for signal propagation and channel activation over dendrites is a function of the cell type-specific dendritic structure. By applying an extended analysis of signal attenuation for the physiological distributions of synaptic inputs and active channels on dendritic branches, we first demonstrate that regardless of their specific structure, all anatomically reconstructed models of primary neurons display a similar pattern of directional signal attenuation and locational channel activation over their dendrites. Then, using a novel modeling approach that allows direct comparison of the anatomically reconstructed primary neurons with their reduced models that exclusively retain anatomical dendritic signaling without being associated with structural specificity, we show that the reduced model can accurately predict dendritic excitability of the anatomical model in both passive and active mode. These results indicate that the directional signaling, locational excitability and their relationship are foundational features of dendritic processing that are independent of the cell type-specific structure across primary neurons.
authors.affiliation: Division of IoT·Robotics Convergence Research, DGIST, 50-1, Sang, Hyeonpung, Dalseong, Daegu, Gyeongbuk 711-873, Republic of Korea; Department of Physiology, Northwestern University of Medicine, Chicago, USA. Electronic address: hojeong.kim03@gmail.com.
authors.forename: Hojeong
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Physiology, Northwestern University of Medicine, Chicago, USA; Department of Physical Medicine and Rehabilitation, and Physical Therapy and Human Movement Science, Northwestern University Feinberg School of Medicine, Chicago, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Heckman
mesh_terms: D000818:Animals; D056654:CA3 Region, Hippocampal / Q000166:cytology; D020746:Calcium Channels, L-Type / Q000502:physiology; D002415:Cats; D003712:Dendrites / Q000502:physiology*; D015640:Ion Channel Gating; D019579:Neocortex / Q000166:cytology; D018408:Patch-Clamp Techniques; D011689:Purkinje Cells / Q000502:physiology / Q000648:ultrastructure; D017966:Pyramidal Cells / Q000502:physiology / Q000648:ultrastructure; D051381:Rats; D013116:Spinal Cord / Q000166:cytology
chemical_list: D020746:Calcium Channels, L-Type
keywords: Dendritic excitability; Dendritic structure; Primary neurons; Reduced modelling; Signal propagation