title: Statins and hip fracture risk in men: a population-based case-control study.
abstract: OBJECTIVE
  To estimate the association between hydroxymethylglutaryl-CoA inhibitor (statin) use and hip fracture.
  
  
  METHODS
  We conducted a population-based case-control study. Cases were 6774 male enrollees in a large managed care organization, aged 45 or more years, with an incident hip fracture from 1997 to 2006. Controls without fracture (n = 6774) were matched to cases on age, race, and medical center. Electronic information on pharmaceutical use was used to identify the dispensing of statins from 1991 forward.
  
  
  RESULTS
  Overall, 1884 (27.8%) cases and 2150 controls (31.7%) used a statin before index date (matched odds ratio [mOR] = 0.81, 95% confidence interval [CI] = 0.74-0.87). Adjustment for comorbidity burden strengthened the magnitude of the overall association (mOR = 0.68, CI = 0.62-0.74). The adjusted association was similar across age groups but was strongest among men aged 80 years or more (mOR = 0.62, CI = 0.54-0.71) and was most pronounced in African Americans (mOR = 0.43, CI = 0.28-0.64). Greater duration of statin use did not alter the odds ratios.
  
  
  CONCLUSIONS
  These data add to the growing evidence of a potential protective effect of statin use on bone health. However, these results need to be replicated in a prospective study that can account for confounding by indication which may explain these findings.
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena. Electronic address: Annette.L.Adams@kp.org.
authors.forename: Annette L
authors.initials: AL
authors.lastname: Adams
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Jiaxiao M
authors.initials: JM
authors.lastname: Shi
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Kristi
authors.initials: K
authors.lastname: Reynolds
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Reina
authors.initials: R
authors.lastname: Haque
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: T Craig
authors.initials: TC
authors.lastname: Cheetham
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Aniket A
authors.initials: AA
authors.lastname: Kawatkar
authors.affiliation: Department of Orthopedic Surgery, Kaiser Permanente Southern California, San Diego.
authors.forename: Donald C
authors.initials: DC
authors.lastname: Fithian
authors.affiliation: Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Jacobsen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002140:California / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D016022:Case-Control Studies; D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D005006:Ethnicity / Q000706:statistics & numerical data*; D015438:Health Behavior; D006620:Hip Fractures / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D015994:Incidence; D008297:Male; D055118:Medication Adherence / Q000208:ethnology; D008875:Middle Aged; D016017:Odds Ratio; D011159:Population Surveillance; D012306:Risk
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Hip fractures; Hydroxymethylglutaryl-CoA reductase inhibitors; Pharmacoepidemiology; Statins