title: Structural Characteristics of Retinal Layers Adjacent to Geographic Atrophy.
abstract: OBJECTIVE
  To compare the anatomy of different retinal layers adjacent to areas of geographic atrophy (GA) to those of eyes with no known ocular diseases.
  
  
  METHODS
  Spectral-domain optical coherence tomography (SD-OCT) scans from eyes with GA were retrospectively reviewed. Two scans with no findings suggestive of GA changes on OCT were selected from immediately above and/or below the edge of the lesions. Thickness values of the retinal layers were calculated and compared to values obtained from normal subjects.
  
  
  RESULTS
  Forty-four eyes (30 patients) were compared to 20 healthy eyes. Retinal pigment epithelium (RPE), inner nuclear layer (INL), and full retinal thickness (FRT) values were significantly lower in patients compared to healthy subjects. Thicknesses of all other layers were not significantly different.
  
  
  CONCLUSIONS
  Clinically appearing, non-involved RPE and INL layers of eyes with GA demonstrate significant thinning compared to corresponding layers in eyes with no known ocular diseases.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Sadiq
authors.forename: Mostafa
authors.initials: M
authors.lastname: Hanout
authors.forename: Salman
authors.initials: S
authors.lastname: Sarwar
authors.forename: Nithya
authors.initials: N
authors.lastname: Rajagopalan
authors.forename: Jose R
authors.initials: JR
authors.lastname: Maya
authors.forename: Liz J
authors.initials: LJ
authors.lastname: Zapata
authors.forename: Diana V
authors.initials: DV
authors.lastname: Do
authors.forename: Quan D
authors.initials: QD
authors.lastname: Nguyen
authors.forename: Yasir J
authors.initials: YJ
authors.lastname: Sepah
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D057092:Geographic Atrophy / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055351:Retinal Neurons / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence