title: Comparative study on the effects of EGF and bFGF on the healing of human large traumatic perforations of the tympanic membrane.
abstract: OBJECTIVE
  We evaluated the effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on the healing of large traumatic tympanic membrane perforations (TMPs).
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  Tertiary university hospital.
  
  
  METHODS
  A randomized, prospective analysis was performed between June 2013 and August 2014 on the treatment of traumatic TMPs larger than 25% of the TM. Closure rate, closure time, hearing gain, and rate of otorrhea were compared between EGF and bFGF groups, as well as to an observation-only group.
  
  
  RESULTS
  Final analysis was performed on 86 patients at 3 months. The closure rates of perforation in the EGF, bFGF, and observation groups were 86.2%, 89.3%, and 72.4%, respectively. The closure rates in the EGF and bFGF groups were 14% to 17% higher than in the observation group, although the difference was not statistically significant for the total closure rate among the three groups (P = 0.200). The average closure time was significantly longer (P < 0.01) in the observation group than in the EGF and bFGF groups. However, the closure times in the EGF and bFGF groups were not significantly different (P = 0.92). In addition, differences in purulent otorrhea rates among the groups were not statistically significant (P = 0.82).
  
  
  CONCLUSIONS
  Both EGF and bFGF can accelerate the closure of human large traumatic TMPs. The healing outcomes among the two growth factors were not significantly different.
authors.affiliation: Department of Otorhinolaryngology, The Affiliated YiWu Hospital of Wenzhou Medical University, Zhejiang, People's Republic of China.
authors.lastname: Zhengcai-Lou
authors.affiliation: Department of Clinical Medicine, Xinxiang Medical University, Henan, People's Republic of China.
authors.lastname: Zihan-Lou
authors.affiliation: Department of Pathology, The Affiliated YiWu Hospital of Wenzhou Medical University, Zhejiang, People's Republic of China.
authors.lastname: Yongmei-Tang
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D004815:Epidermal Growth Factor / Q000008:administration & dosage*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000187:drug effects*; D018058:Tympanic Membrane Perforation / Q000188:drug therapy* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
chemical_list: D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor
keywords: Traumatic; basic fibroblast growth factor; epidermal growth factor; healing outcome; tympanic membrane perforation