title: [Preventive effects of lutein on liver toxicity in mice induced by arsenic].
abstract: OBJECTIVE
  To explore the intervention effects of lutein on liver toxicity in mice induced by arsenic trioxide (As2O3) and to evaluate the preventive effect and the antioxidant mechanism of lutein.
  
  
  METHODS
  A total of 84 healthy KM mice were randomly divided into eight groups. There were 35 d control group, 70 d control group, 35 d lutein group, 70 d lutein group, arsenic exposure group, lutein treatment group and lutein prevention group. The activity and level of AST, ALT, T-AOC, MDA, GSH, SOD, NO in liver tissue were measured by kits. Compares the difference between each group of the single factor analysis of variance.
  
  
  RESULTS
  The activity of ALT, AST and the contents of MDA of 70 d control group were significantly lower than that arsenic exposure group. The contents of GSH, T-AOC, NO and the activity of SOD of 70 d control group were increased significantly than arsenic exposure group. The activity of ALT, AST and the contents of MDA of lutein prevention group were significantly lower than that lutein treatment group. The contents of GSH, T-AOC, NO and the activity of SOD of lutein prevention group were increased significantly than lutein treatment group. The differences were statistically significant (P < 0.05).
  
  
  CONCLUSIONS
  Lutein can improve antioxidation function and has protective effect on liver injury of mice induced by arsenic.
authors.forename: Mingke
authors.initials: M
authors.lastname: Niu
authors.forename: Shugang
authors.initials: S
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Niu
authors.forename: Shangzhi
authors.initials: S
authors.lastname: Xu
authors.forename: Jiaonan
authors.initials: J
authors.lastname: Xiao
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Wen
authors.forename: Gangling
authors.initials: G
authors.lastname: Feng
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001151:Arsenic / Q000633:toxicity*; D018053:Arsenites / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D008099:Liver / Q000473:pathology; D014975:Lutein / Q000494:pharmacology*; D051379:Mice
chemical_list: D000975:Antioxidants; D018053:Arsenites; D001151:Arsenic; D014975:Lutein