title: Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with Aortic Stenosis.
abstract: Elevation in C-reactive protein (CRP) levels have been shown in patients with aortic valve stenosis (AS). Minor allele of the CRP gene (CRP) rs1205 C>T polymorphism has been associated with lower plasma CRP concentrations in cohorts of healthy and atherosclerotic patients. Considering the existing similarities between atherosclerosis and AS, we examined the effect of CRP rs1205 C>T polymorphism on the AS severity. Three hundred consecutive Caucasian patients diagnosed with AS were genotyped for the rs1205 C>T polymorphism using the TaqMan assay. Severity of the AS was assessed using transthoracic echocardiography. The degree of calcification was analyzed semi-quantitatively. Carriers of the rs1205 T allele were characterized by elevated serum CRP levels (2.53 (1.51-3.96) vs. 1.68 (0.98-2.90) mg/L, p<0.001) and a higher proportion of the severe aortic valve calcification (70.4% vs. 55.1%, p=0.01) compared with major homozygotes. The effect of CRP rs1205 polymorphism on CRP levels is opposite in AS-affected than in unaffected subjects, suggesting existence of a disease-specific molecular regulatory mechanism. Furthermore, rs1205 variant allele predisposes to larger aortic valve calcification, potentially being a novel genetic risk marker of disease progression.
authors.affiliation: Institute of Cardiology, School of Medicine, Jagiellonian University, 31-202 Cracow, Poland. ewa.wypasek@uj.edu.pl.|John Paul II Hospital, 31-202 Cracow, Poland. ewa.wypasek@uj.edu.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wypasek
authors.affiliation: John Paul II Hospital, 31-202 Cracow, Poland. potaczek@staff.uni-marburg.de.|Institute of Laboratory Medicine, Philipps-Universität Marburg, 35043 Marburg, Germany. potaczek@staff.uni-marburg.de.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Potaczek
authors.affiliation: Institute of Cardiology, School of Medicine, Jagiellonian University, 31-202 Cracow, Poland. mmundas@cyf-kr.edu.pl.|John Paul II Hospital, 31-202 Cracow, Poland. mmundas@cyf-kr.edu.pl.
authors.forename: Anetta
authors.initials: A
authors.lastname: Undas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000378:metabolism / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000235:genetics* / Q000378:metabolism; D002097:C-Reactive Protein / Q000235:genetics*; D002114:Calcinosis / Q000235:genetics* / Q000378:metabolism; D004452:Echocardiography; D005260:Female; D005819:Genetic Markers; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: D005819:Genetic Markers; D002097:C-Reactive Protein
keywords: CRP; CRP rs1205 C&gt; T polymorphism; aortic valve stenosis; calcification