title: Synthesis and antimicrobial activity of polysaccharide alginate derived cationic surfactant-metal(II) complexes.
abstract: New natural polysaccharide carbohydrate derivatives of sodium alginate surfactant and its cobalt, copper and zinc complexes were synthesized. Structures of the synthesized compounds are reported using FTIR, (1)H NMR and UV-vis. The critical micelle concentration (CMC) value of the alginate surfactant and its metal complexes in aqueous solution was found out from surface tension measurements. Surface tension data at different temperatures served for the evaluation of the temperature-dependent CMC and the thermodynamics of micellization (ΔGmic, ΔHmic, ΔSmic) and adsorption (ΔGads, ΔGads, ΔSads). The surface activities of the synthesized polymeric surfactant and its metal complexes were influenced by their chemical structures and the type of the transition metals. These compounds were evaluated against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungi (Candida albicans and Asperigllus niger). The antibacterial and antifungal screening tests of the alginate surfactant metal complexes have shown good results compared to its precursor alginate surfactant.
authors.affiliation: Petrochemicals Department, Egyptian Petroleum Research Institute, Nasr City, Cairo, Egypt. Electronic address: salahtwfk85@yahoo.com.
authors.forename: Salah M
authors.initials: SM
authors.lastname: Tawfik
authors.affiliation: Petrochemicals Department, Egyptian Petroleum Research Institute, Nasr City, Cairo, Egypt.
authors.forename: Hassan H
authors.initials: HH
authors.lastname: Hefni
mesh_terms: D000327:Adsorption; D000464:Alginates / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D002412:Cations / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D008823:Micelles; D008826:Microbial Sensitivity Tests; D011134:Polysaccharides / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013500:Surface Tension; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D000464:Alginates; D000890:Anti-Infective Agents; D002412:Cations; D006603:Hexuronic Acids; D008670:Metals; D008823:Micelles; D011134:Polysaccharides; D013501:Surface-Active Agents; D020723:Glucuronic Acid
keywords: Alginate surfactant; Antimicrobial; Critical micelle concentration; Metal complexes; Thermodynamics