title: Non-leaching antimicrobial biodegradable PBAT films through a facile and novel approach.
abstract: The antimicrobial thermoplastic starch (ATPS) containing guanidine-based polymers was obtained using a twin-screw extrusion with potato starch and polyhexamethylene guanidine hydrochloride (PHGH). Furthermore, the non-leaching antimicrobial biodegradable poly(butylene adipate-co-terephthalate) (PBAT) was prepared through reactive extrusion with PBAT and ATPS in the presence of the coupling agent, 2,2'-(1,3-phenylene)-bis (2-oxazoline) (PBO). Finally, the antimicrobial PBAT films were obtained by using a blown film extrusion system. The mechanical properties of the antimicrobial PBAT films varied with the contents of ATPS and thermoplastic starch (TPS). According to the test results of shaking flask method, the prepared antimicrobial PBAT films showed excellent antimicrobial activities (antimicrobial rate >99.99%) and rapid pathogen deactivation efficiency (antimicrobial rate >99.99% even within 15s of contact time). The water washing and ring diffusion tests demonstrated that the antimicrobial film was a non-leaching product. Inspiringly, the antimicrobial PBAT films with an excellent antimicrobial activity can be obtained even at a very low dosage of PHGH (1.0 mg/g PBAT film).
authors.affiliation: Department of Chemical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada; School of Materials Science and Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Dafu
authors.initials: D
authors.lastname: Wei
authors.affiliation: Department of Chemical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Ziaee
authors.affiliation: Department of Chemical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada.
authors.forename: Felipe
authors.initials: F
authors.lastname: Chibante
authors.affiliation: School of Materials Science and Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Anna
authors.initials: A
authors.lastname: Zheg
authors.affiliation: Department of Chemical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada. Electronic address: hxiao@unb.ca.
authors.forename: Huining
authors.initials: H
authors.lastname: Xiao
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D055119:Elastic Modulus; D004926:Escherichia coli / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry* / Q000494:pharmacology; D013213:Starch / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D011091:Polyesters; C488797:poly(butylene adipate-co-butylene terephthalate); D013213:Starch
keywords: Antimicrobial activities; Biodegradable; Guanidine; PBAT; Starch