title: Pathophysiology of hidradenitis suppurativa: An update.
abstract: The pathogenesis of hidradenitis suppurativa (HS) or acne inversa is not completely understood. Recent research has led to greater insight into the mechanisms involved in the disease. The primary defect in HS pathophysiology rests with the hair follicle. Follicular occlusion, followed by follicular rupture, and a foreign body-type immune response are necessary conditions for the development of clinical HS. A specific genetic signature and environmental factors, such as cigarette smoking, microbial colonization, and adiposity, all contribute to the HS phenotype. Translational research focused on the inflammatory mechanisms involved in HS is needed to develop novel therapeutic options for this debilitating disease.
authors.affiliation: Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: e.prens@erasmusmc.nl.
authors.forename: Errol
authors.initials: E
authors.lastname: Prens
authors.affiliation: Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Inge
authors.initials: I
authors.lastname: Deckers
mesh_terms: D000328:Adult; D001050:Apocrine Glands / Q000276:immunology / Q000503:physiopathology*; D015551:Autoimmunity / Q000502:physiology; D001707:Biopsy, Needle; D016207:Cytokines / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D017497:Hidradenitis Suppurativa / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000503:physiopathology; D008297:Male; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D055815:Young Adult
chemical_list: D016207:Cytokines
keywords: acne inversa; antimicrobial peptides; autoinflammation; cytokines; friction; hidradenitis suppurativa; immunology; tobacco smoke