title: Anxiolytic Activity of Diterpene Alkaloid Songorine.
abstract: Antianxiety action of diterpene alkaloid songorine was studied using Vogel conflict test. Songorine in a dose of 0.25 mg/kg demonstrated high anxiolytic activity comparable to that of phenazepam and produced no sedative effect.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. nes-yuliya@yandex.ru.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nesterova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: T N
authors.initials: TN
authors.lastname: Povet'eva
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.affiliation: N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Shults
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: G N
authors.initials: GN
authors.lastname: Ziuz'kov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Aksinenko
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Afanas'eva
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Krapivin
authors.affiliation: Tomsk National Research State University, Tomsk, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Kharina
mesh_terms: D031841:Aconitum / Q000737:chemistry; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000494:pharmacology; D003220:Conflict, Psychological; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000470:Alkaloids; D014151:Anti-Anxiety Agents; D004224:Diterpenes; D001569:Benzodiazepines; C017928:phenazepam; C057217:songorine
keywords: anxiolytic activity; diterprene alkaloids