title: Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs.
abstract: Innate lymphoid cells (ILCs) contribute to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout the body. How ILCs maintain their presence in lymphoid and peripheral tissues thus far has been unclear. We found that in the lymphoid and nonlymphoid organs of adult mice, ILCs are tissue-resident cells that were maintained and expanded locally under physiologic conditions, upon systemic perturbation of immune homeostasis and during acute helminth infection. However, at later time points after infection, cells from hematogenous sources helped to partially replenish the pool of resident ILCs. Thus, ILCs are maintained by self-renewal in broadly different microenvironments and physiological settings. Such an extreme "sedentary" lifestyle is consistent with the proposed roles of ILCs as sentinels and local keepers of tissue function.
authors.affiliation: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Institute of Medical Microbiology and Hygiene, University of Mainz Medical Centre, Mainz 55131, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Gasteiger
authors.affiliation: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Xiying
authors.initials: X
authors.lastname: Fan
authors.affiliation: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Stanislav
authors.initials: S
authors.lastname: Dikiy
authors.affiliation: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Sue Y
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Alexander Y
authors.initials: AY
authors.lastname: Rudensky
mesh_terms: D000818:Animals; D005260:Female; D006373:Helminthiasis / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D007113:Immunity, Innate; D007421:Intestine, Small / Q000166:cytology / Q000276:immunology; D008168:Lung / Q000166:cytology / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009928:Organ Specificity / Q000276:immunology; D010227:Parabiosis; D012469:Salivary Glands / Q000166:cytology / Q000276:immunology