title: Insulin resistance and lipid profile during an oral glucose tolerance test in women with and without gestational diabetes mellitus.
abstract: We aimed to compare changes in insulin levels during an oral glucose tolerance test (OGTT) between women with normal glucose tolerance (NGT) during pregnancy and those with gestational diabetes mellitus (GDM). Overall, 105 pregnant women between 24 and 28 weeks' gestation, 50 with NGT and 55 with GDM according to NDDG standard, were enrolled into the study. The levels of fasting blood glucose, insulin, triglyceride (TG) and total cholesterol (TC) and the insulin levels, blood glucose levels at 1, 2 and 3 hours post oral glucose administration during an OGTT (5.8, 10.6, 9.2 and 8.1 mmol/L, respectively) were measured. Then, insulin resistance (IR) index was calculated. There was no significant difference in fasting, 3-h insulin levels and 3-h blood glucose levels between those with NGT and those with GDM (P > 0.05). However, 1-h and 2-h insulin levels, fasting and 1-h and 2-h blood glucose levels in women with GDM were significantly higher than those in the NGT group (P < 0.05). Fasting TC and TG levels in the GDM group were significantly higher than those with NGT (P = 0.031 and P = 0.025, respectively). Correlation analysis showed that TG and TC levels were positively correlated with homoeostasis model assessment-IR (HOMA-IR) (r = 0.67 and r = 0.78, respectively; P < 0.05). Our findings suggest that insulin sensitivity in women with GDM was significantly lower than that observed in those with NGT. Reducing IR and blood lipids in women with GDM could potentially improve maternal and foetal outcomes.
authors.affiliation: a Obstetrical Department, Women's Hospital , School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Zx
authors.initials: Z
authors.lastname: Liang
authors.affiliation: a Obstetrical Department, Women's Hospital , School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.affiliation: a Obstetrical Department, Women's Hospital , School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Xy
authors.initials: X
authors.lastname: Zhu
authors.affiliation: a Obstetrical Department, Women's Hospital , School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Q
authors.initials: Q
authors.lastname: Fang
authors.affiliation: a Obstetrical Department, Women's Hospital , School of Medicine, Zhejiang University , Hangzhou , China.
authors.forename: Dq
authors.initials: D
authors.lastname: Chen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol
keywords: Gestational diabetes mellitus; insulin; insulin resistance; lipids; oral glucose tolerance test