title: Hydrotalcite catalysis for the synthesis of new chiral building blocks.
abstract: The use of hydrotalcites for the synthesis of two chiral building blocks in a simple way is described as a new and green methodology. The synthesis of these compounds implies a regioselective Baeyer-Villiger reaction in a very selective way with ulterior opening and lactonisation. This methodology should be considered green for the use of hydrogen peroxide as the only oxidant and hydrotalcites as the catalyst, and because no residues are produced apart from water. The procedure is very adequate for using in gram scale, in order to increase the value of the obtained compounds. The conditions are excellent and can be applied for nonstable compounds, as they are very mild. The synthesised compounds are magnific starting materials for the synthesis of biologically active or natural compounds. The use of a cheap, commercial and chiral compound as carvone disposable in both enantiomeric forms adds an extra value to this methodology.
authors.affiliation: a Faculdade de Ciências, Departamento de Química and UMTP-FibEnTech , Universidade da Beira Interior , Covilhã , Portugal.
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Rodilla
authors.affiliation: a Faculdade de Ciências, Departamento de Química and UMTP-FibEnTech , Universidade da Beira Interior , Covilhã , Portugal.
authors.forename: Patricia P
authors.initials: PP
authors.lastname: Neves
authors.affiliation: a Faculdade de Ciências, Departamento de Química and UMTP-FibEnTech , Universidade da Beira Interior , Covilhã , Portugal.
authors.forename: Sofia
authors.initials: S
authors.lastname: Pombal
authors.affiliation: b GIR-QUESCAT-Departamento de Química Inorgánica , Universidad de Salamanca , Salamanca , Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Rives
authors.affiliation: b GIR-QUESCAT-Departamento de Química Inorgánica , Universidad de Salamanca , Salamanca , Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Trujillano
authors.affiliation: c Facultad de Ciencias Químicas, Departamento de Química Orgánica , Universidad de Salamanca , Salamanca , Spain.
authors.forename: David
authors.initials: D
authors.lastname: Díez
mesh_terms: D000536:Aluminum Hydroxide / Q000737:chemistry*; D002384:Catalysis; D000081005:Cyclohexane Monoterpenes; D055772:Green Chemistry Technology; D006861:Hydrogen Peroxide / Q000737:chemistry; D008276:Magnesium Hydroxide / Q000737:chemistry*; D039821:Monoterpenes / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D016877:Oxidants; C010467:hydrotalcite; D000536:Aluminum Hydroxide; C006923:carvone; D006861:Hydrogen Peroxide; D008276:Magnesium Hydroxide
keywords: Hydrotalcites; carvone; hydrogen peroxide; natural products; terpenes