title: Does Intensive Glucose Control Prevent Cognitive Decline in Diabetes? A Meta-Analysis.
abstract: Diabetes mellitus is associated with cognitive decline and impaired performance in cognitive function tests among type 1 and type 2 diabetics. Even though the use of tight glucose control has been limited by a reported higher mortality, few reports have assessed the impact of treatment intensity on cognitive function. We conducted a meta-analysis to evaluate if an intensive glucose control in diabetes improves cognitive function, in comparison to standard therapy. We included 7 studies that included type 1 or type 2 diabetics and used standardized tests to evaluate various cognitive function domains. Standardized mean differences (SMDs) were calculated for each domain. We found that type 1 diabetics get no cognitive benefit from a tight glucose control, whereas type 2 diabetics get some benefit on processing speed and executive domains but had worse performances in the memory and attention domains, along with a higher incidence of mortality when using intensive glucose control regimes.
authors.affiliation: Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador.
authors.forename: Carlos
authors.initials: C
authors.lastname: Peñaherrera-Oviedo
authors.affiliation: Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador.
authors.forename: Daniel
authors.initials: D
authors.lastname: Moreno-Zambrano
authors.affiliation: Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador.
authors.forename: Michael
authors.initials: M
authors.lastname: Palacios
authors.affiliation: Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador.
authors.forename: María Carolina
authors.initials: MC
authors.lastname: Duarte-Martinez
authors.affiliation: Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cevallos
authors.affiliation: Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador.
authors.forename: Ximena
authors.initials: X
authors.lastname: Gamboa
authors.affiliation: Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador.
authors.forename: María Beatriz
authors.initials: MB
authors.lastname: Jurado
authors.affiliation: Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Tamariz
authors.affiliation: Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
authors.forename: Ana
authors.initials: A
authors.lastname: Palacio
authors.affiliation: Universidad Catolica de Santiago de Guayaquil, 090112 Guayas, Ecuador.
authors.forename: Rocío
authors.initials: R
authors.lastname: Santibañez