title: Renal artery stenosis and mean platelet volume.
abstract: OBJECTIVE
  Increased mean platelet volume (MPV) has been reported in various atherosclerotic diseases. The aim of our study was to investigate the relationship between the atherosclerotic renal artery stenosis (ARAS) and various hematological parameters including MPV.
  
  
  METHODS
  This study was performed with a retrospective review of the angiographic images of patients who underwent renal angiography at Bülent Ecevit University catheter laboratory between January 2004 and December 2009. The patients were trichotomized into three groups based on the presence and severity of renal artery stenosis (RAS). Group 1 included patients with a critical RAS (33 patients; 18 female (F), 15 male (M); mean age 61.6 ± 11.5 years), group 2 consisted of patients with non-critical RAS (26 patients; 15 F, 11 M; mean age 58. 1 ± 11.3 years), and group 3 was composed of patients without RAS (69 patients; 38 F, 31 M; mean age 53.5 ± 11.9 years). Demographic data, complete blood count, and biochemical parameters were compared between the groups.
  
  
  RESULTS
  Comparison of the hematological parameters revealed that MPV and platelet distribution width were significantly higher in group 1 than in group 2 and 3 (8.96 ± 0.99 fL versus 8.35 ± 0.76 fL, 8.31 ± 0.79 fL, respectively; p=0.001; 16.53 ± 0.58% versus 16.19 ± 0.56%, 16.29 ± 0.53%, respectively; p=0.04).
  
  
  CONCLUSIONS
  MPV levels are higher in patients with ARAS. Considering both the effect of platelets on atherosclerosis and their close association with other risk factors, MPV level may be an important factor in pathogenesis of ARAS.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bülent Ecevit University; Zonguldak-Turkey. sayinmr@mynet.com.
authors.forename: Muhammet Raşit
authors.initials: MR
authors.lastname: Sayın
authors.forename: Nesimi
authors.initials: N
authors.lastname: Yavuz
authors.forename: Turgut
authors.initials: T
authors.lastname: Karabağ
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Çetiner
authors.forename: İbrahim İlker
authors.initials: İİ
authors.lastname: Öz
authors.forename: Orhan Alper
authors.initials: OA
authors.lastname: Güngördük
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aydın
mesh_terms: D000792:Angiography; D015415:Biomarkers; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers