title: Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media.
abstract: BACKGROUND
  The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of Pseudomonas aeruginosa from the patients with chronic suppurative otitis media (CSOM).
  
  
  METHODS
  We examined bactericidal activity of four types of fluoroquinolones, garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of P. aeruginosa (50 strains).
  
  
  RESULTS
  STFX exhibited the most potent activity of both MIC50 and MIC90, followed by CPFX, LVFX, and GRNX. The number of GRNX-resistant strains was significantly greater than those of LVFX, CPFX, and STFX (P < 0.05).
  
  
  CONCLUSIONS
  STFX showed the most potent activity against P. aeruginosa for recent pathogens recovered from CSOM as compared with the others, suggesting that the clinical application of topical STFX would be useful to prevent the emergence of resistant mutants of P. aeruginosa.
authors.affiliation: Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 Japan.
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Ikeda
authors.affiliation: Microbiology Laboratory, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Misawa
authors.affiliation: Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kusunoki
keywords: Bactericidal activity; Chronic suppurative otitis media; Fluoroquinolone; Minimum inhibitory concentration; Pseudomonas aeruginosa