title: PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats.
abstract: The aim of this study was to demonstrate the potential of a wireless pixelated β+-sensitive intracerebral probe (PIXSIC) for in vivo positron emission tomographic (PET) radiopharmacology in awake and freely moving rodents. The binding of [(11)C]raclopride to D2 dopamine receptors was measured in anesthetized and awake rats following injection of the radiotracer. Competitive binding was assessed with a cold raclopride injection 20 minutes later. The device can accurately monitor binding of PET ligands in freely moving rodents with a high spatiotemporal resolution. Reproducible time-activity curves were obtained for pixels throughout the striatum and cerebellum. A significantly lower [(11)C]raclopride tracer-specific binding was observed in awake animals. These first results pave the way for PET tracer pharmacokinetics measurements in freely moving rodents.
authors.forename: Laure
authors.initials: L
authors.lastname: Balasse
authors.forename: Julia
authors.initials: J
authors.lastname: Maerk
authors.forename: Frédéric
authors.initials: F
authors.lastname: Pain
authors.forename: Aurelie
authors.initials: A
authors.lastname: Genoux
authors.forename: Sylvain
authors.initials: S
authors.lastname: Fieux
authors.forename: Françoise
authors.initials: F
authors.lastname: Lefebvre
authors.forename: Christian
authors.initials: C
authors.lastname: Morel
authors.forename: Pascale
authors.initials: P
authors.lastname: Gisquet-Verrier
authors.forename: Philippe
authors.initials: P
authors.lastname: Lanièce
authors.forename: Luc
authors.initials: L
authors.lastname: Zimmer
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D008297:Male; D009068:Movement; D020891:Raclopride / Q000378:metabolism*; D011877:Radionuclide Imaging; D017207:Rats, Sprague-Dawley; D059015:Wireless Technology
chemical_list: D002250:Carbon Radioisotopes; D020891:Raclopride