title: The Learning Early About Peanut Allergy Study: The Benefits of Early Peanut Introduction, and a New Horizon in Fighting the Food Allergy Epidemic.
abstract: Observational studies have explored associations between timing of peanut, egg, and milk introduction and food allergy development, noting significant associations with reduced respective rates of milk, egg, and peanut allergy associated with earlier timing of introduction. Interventional studies developed to more definitively explore these outcomes have been published for egg and peanut, and are ongoing for multiple other allergens. This review focuses on the recent publication regarding the LEAP (Learning Early About Peanut Allergy) study, its highly favorable results, the policy implications of its findings, and the horizon for primary prevention as a realistic strategy to prevent food allergy.
authors.affiliation: Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan Medical School, 24 Frank Lloyd Wright Drive, Lobby H-2100, Box 442, Ann Arbor, MI 48106, USA; Child Health Evaluation and Research Unit, Department of Pediatrics, University of Michigan Medical School, 24 Frank Lloyd Wright Drive, Lobby H-2100, Box 442, Ann Arbor, MI 48106, USA. Electronic address: mgreenha@med.umich.edu.
authors.forename: Matthew
authors.initials: M
authors.lastname: Greenhawt
mesh_terms: D000485:Allergens / Q000276:immunology; D010367:Arachis / Q000276:immunology; D002648:Child; D004485:Eczema / Q000150:complications; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D021183:Peanut Hypersensitivity / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D011322:Primary Prevention; D011379:Prognosis; D012306:Risk; D012882:Skin Tests; D013997:Time Factors
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: Anaphylaxis; Food allergy; Food sensitization; LEAP study; Oral food challenge; Peanut allergy; Primary prevention; Skin-prick testing