title: [ROLE OF microRNA IN SKIN DEVELOPMENT AND WOUND HEALING].
abstract: OBJECTIVE
  To review the role of microRNA (miRNA) in skin development and wound healing.
  
  
  METHODS
  The recent literature about miRNA in skin development and wound healing was reviewed and analyzed.
  
  
  RESULTS
  miRNA extensively involved in the development of the skin, including epidermal cell proliferation, differentiation, aging and hair follicle development; miR-203 known as the "skin-specific miRNA" can directly inhibit the expression of p63 and promote the differentiation of the epidermis. Meanwhile, miRNA also involved in various stages of skin regeneration and wound healing. Abnormal expression of miRNA is closely related with abnormal wound healing.
  
  
  CONCLUSIONS
  miRNA play an important role in maintaining normal skin physiology and skin regeneration. To explore their roles in the healing of skin wounds and their regulatory mechanism can provide a new target for the treatment, which has a potential value and broad prospects.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Song
authors.forename: Dewu
authors.initials: D
authors.lastname: Liu
mesh_terms: D002454:Cell Differentiation; D003094:Collagen / Q000378:metabolism; D004817:Epidermis; D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D012038:Regeneration; D012867:Skin / Q000378:metabolism* / Q000473:pathology*; D015854:Up-Regulation / Q000235:genetics; D014945:Wound Healing / Q000235:genetics*
chemical_list: C546703:MIRN203 microRNA, human; D035683:MicroRNAs; D003094:Collagen