title: Effects of a New Benzimidazole Derivative on Generative Function of Female Rats.
abstract: The effects of a new thietanylbenzimidazole derivative (K-134) on estrous cycles, conception processes, and sexual behavior of female rats were studied. Two-week oral treatment with K-134 in doses of 5 and 50 mg/kg shortened the estrus phase and prolonged proestrus. Changes in sexual behavior were presented by activation of receptive sexual motivations without affecting proceptive motivations. The pregnancy and fertility indexes in experimental females after mating with intact males increased and pre- and postimplantation embryonic death decreased.
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Kuzubova
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia. lb.bugaeva@rambler.ru.
authors.forename: L I
authors.initials: LI
authors.lastname: Bugaeva
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Petrov
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Kataev
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Kharlamov
authors.affiliation: Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Mal'tsev
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001562:Benzimidazoles / Q000494:pharmacology*; D030762:Estrous Cycle / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology*; D005306:Fertilization / Q000187:drug effects* / Q000502:physiology; D046689:Fetal Mortality; D056084:Genetic Fitness / Q000187:drug effects* / Q000502:physiology; D007989:Libido / Q000187:drug effects; D008098:Litter Size / Q000187:drug effects / Q000502:physiology; D008297:Male; D011247:Pregnancy; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects* / Q000502:physiology
chemical_list: D001562:Benzimidazoles; D005300:Fertility Agents, Female
keywords: actoprotectors; benzimidazole derivatives; estrous cycle; reproductivity; sexual behavior