title: 50 years of Arabidopsis research: highlights and future directions.
abstract: 922 I. 922 II. 922 III. 925 IV. 925 V. 926 VI. 927 VII. 928 VIII. 929 IX. 930 X. 931 XI. 932 XII. 933 XIII. Natural variation and genome-wide association studies 934 XIV. 934 XV. 935 XVI. 936 XVII. 937 937 References 937 SUMMARY: The year 2014 marked the 25(th) International Conference on Arabidopsis Research. In the 50 yr since the first International Conference on Arabidopsis Research, held in 1965 in Göttingen, Germany, > 54 000 papers that mention Arabidopsis thaliana in the title, abstract or keywords have been published. We present herein a citational network analysis of these papers, and touch on some of the important discoveries in plant biology that have been made in this powerful model system, and highlight how these discoveries have then had an impact in crop species. We also look to the future, highlighting some outstanding questions that can be readily addressed in Arabidopsis. Topics that are discussed include Arabidopsis reverse genetic resources, stock centers, databases and online tools, cell biology, development, hormones, plant immunity, signaling in response to abiotic stress, transporters, biosynthesis of cells walls and macromolecules such as starch and lipids, epigenetics and epigenomics, genome-wide association studies and natural variation, gene regulatory networks, modeling and systems biology, and synthetic biology.
authors.affiliation: Department of Cell & Systems Biology/CAGEF, University of Toronto, Toronto, ON, M5S 3B2, Canada.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Provart
authors.affiliation: Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, 27695, USA.
authors.forename: Jose
authors.initials: J
authors.lastname: Alonso
authors.affiliation: Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Assmann
authors.affiliation: Department of Biology, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bergmann
authors.affiliation: Department of Plant Biology, University of California, Davis, CA, 95616, USA.
authors.forename: Siobhan M
authors.initials: SM
authors.lastname: Brady
authors.affiliation: Arabidopsis Biological Resource Center, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Jelena
authors.initials: J
authors.lastname: Brkljacic
authors.affiliation: Institute of Biological Chemistry, Washington State University, Pullman, WA, 99164, USA.
authors.forename: John
authors.initials: J
authors.lastname: Browse
authors.affiliation: Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA.
authors.forename: Clint
authors.initials: C
authors.lastname: Chapple
authors.affiliation: Departement de Biologie École Normale Supérieure, Biologie Moleculaire des Organismes Photosynthetiques, F-75230, Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Colot
authors.affiliation: Department of Botany and Plant Sciences, University of California, Riverside, CA, 92507, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Cutler
authors.affiliation: Department of Biology and Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, 27599, USA.
authors.forename: Jeff
authors.initials: J
authors.lastname: Dangl
authors.affiliation: Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, 94305, USA.
authors.forename: David
authors.initials: D
authors.lastname: Ehrhardt
authors.affiliation: Department of Plant Biology, Agricultural Sustainability Institute, University of California, Davis, CA, 95616, USA.
authors.forename: Joanna D
authors.initials: JD
authors.lastname: Friesner
authors.affiliation: Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, 94305, USA.
authors.forename: Wolf B
authors.initials: WB
authors.lastname: Frommer
authors.affiliation: Center for Applied Plant Science, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Erich
authors.initials: E
authors.lastname: Grotewold
authors.affiliation: Division of Biology and Biological Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, 91125, USA.
authors.forename: Elliot
authors.initials: E
authors.lastname: Meyerowitz
authors.affiliation: Department of Biology, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Nemhauser
authors.affiliation: Gregor Mendel Institute of Molecular Plant Biology, A-1030, Vienna, Austria.
authors.forename: Magnus
authors.initials: M
authors.lastname: Nordborg
authors.affiliation: Department of Biology, Indiana University, Bloomington, IN, 47405, USA.
authors.forename: Craig
authors.initials: C
authors.lastname: Pikaard
authors.affiliation: Biology Department, Brookhaven National Laboratory, Upton, NY, 11973, USA.
authors.forename: John
authors.initials: J
authors.lastname: Shanklin
authors.affiliation: Energy Biosciences Institute, University of California, Berkeley, CA, 94704, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Somerville
authors.affiliation: Metabolic Networks Department, Max Planck Institute for Molecular Plant Physiology, D-14476, Potsdam, Germany.
authors.forename: Mark
authors.initials: M
authors.lastname: Stitt
authors.affiliation: Department of Biology, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Keiko U
authors.initials: KU
authors.lastname: Torii
authors.affiliation: Department of Cell & Systems Biology/CAGEF, University of Toronto, Toronto, ON, M5S 3B2, Canada.
authors.forename: Jamie
authors.initials: J
authors.lastname: Waese
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors.forename: Doris
authors.initials: D
authors.lastname: Wagner
authors.affiliation: Department of Cell & Systems Biology/CAGEF, University of Toronto, Toronto, ON, M5S 3B2, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: McCourt
mesh_terms: D017360:Arabidopsis / Q000276:immunology / Q000502:physiology*; D044127:Epigenesis, Genetic; D057865:Plant Immunity; D012106:Research; D059386:Reverse Genetics; D015398:Signal Transduction
keywords: Arabidopsis; development; epigenetics; genome; model system; reverse genetics; signaling; synthetic biology