title: Effect of angiotensin-(1-7) and angiotensin II on the proliferation and activation of human endometrial stromal cells in vitro.
abstract: Recent studies have shown that angiotensin II (Ang II) or angiotensin-(1-7) [Ang-(1-7)] has effect on the proliferation and activation of a variety of cells, however, the exact mechanisms that the role of Ang II or Ang-(1-7) in human endometrial stromal cell (ESCs) remains elusive. Here we demonstrated that Ang II could promote proliferation and activation of ESCs, up-regulated the expression of a-SMA, TGF-β1 and IGF-I, increased the secretion of extracellular matrix [Type I collagen (Col I) and fibronectin (FN)] of ESCs; Ang-(1-7) could inhibit Ang II induced the proliferation and activation of ESCs, down-regulated the expression of a-SMA, TGF-β1 and IGF-I, decreased the secretion of extracellular matrix (Col I and FN) of ESCs. These findings suggest that Ang-(1-7) can inhibits Ang II induced the proliferation of ESCs, Ang-(1-7) can inhibits the Ang II induced activation of ESCs and decreases secretion of Col I and FN by suppressing TGF-β1 and IGF-I expression.
authors.affiliation: Department of Histology and Embryology, Hebei Medical University Shijiazhuang, Hebei 050017, China ; Department of Histology and Embryology, Hebei Engineering University Handan 056002, China.
authors.forename: Tieying
authors.initials: T
authors.lastname: Shan
authors.affiliation: The In Vitro Fertility Center of Obstetrics & Gynecology, PLA Navy General Hospital Beijing 100048, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shang
authors.affiliation: Department of Histology and Embryology, Hebei Medical University Shijiazhuang, Hebei 050017, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Histology and Embryology, Hebei Medical University Shijiazhuang, Hebei 050017, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Histology and Embryology, Hebei Medical University Shijiazhuang, Hebei 050017, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Histology and Embryology, Hebei Medical University Shijiazhuang, Hebei 050017, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Histology and Embryology, Hebei Engineering University Handan 056002, China.
authors.forename: Guiying
authors.initials: G
authors.lastname: Li
mesh_terms: D000199:Actins / Q000378:metabolism; D000803:Angiotensin I / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D024042:Collagen Type I / Q000378:metabolism; D004717:Endometrium / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology*; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D024042:Collagen Type I; D005353:Fibronectins; D010446:Peptide Fragments; D053773:Transforming Growth Factor beta1; D000804:Angiotensin II; D007334:Insulin-Like Growth Factor I; D000803:Angiotensin I; C118790:angiotensin I (1-7)
keywords: Angiotensin-(1-7); angiotensin II; human endometrial stromal cell; proliferation