title: Are negative symptoms really related to cognition in schizophrenia?
abstract: Previous studies have generally found a relationship between negative and cognitive symptoms in schizophrenia. The present study investigated the relationship between the 5 PANSS factors of a recent consensus model developed by NIMH researchers, and cognitive performance as assessed with the MATRICS Consensus Cognitive Battery (MCCB) in 80 patients with schizophrenia using correlation and regression analyses. The PANSS Cognitive factor showed a small to moderate significant association with MCCB Speed of processing, Working memory, Verbal learning, the Neurocognitive composite score, and the Overall composite score. Notably, however, no relationship was found between the PANSS Negative factor and any of the MCCB scores. The Positive, Excited and Depressed factors also did not show associations with the MCCB. These results highlight the need for refined assessment instruments and support the relative independence of cognition from other domains of psychopathology, including negative symptoms, in patients with schizophrenia.
authors.affiliation: Department of Psychiatry, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bagney
authors.affiliation: Department of Psychiatry, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain.
authors.forename: Monica
authors.initials: M
authors.lastname: Dompablo
authors.affiliation: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain; Department of Preventive Medicine and Public Health, University of Zaragoza, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Santabárbara
authors.affiliation: Department of Psychiatry, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Moreno-Ortega
authors.affiliation: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain; Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Spain; Department of Medicine and Psychiatry, University of Zaragoza, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lobo
authors.affiliation: Department of Psychiatry, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain; Department of Psychiatry, Faculty of Medicine, Universidad Complutense de Madrid, Spain.
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Jimenez-Arriero
authors.affiliation: Department of Psychiatry, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain; Department of Psychiatry, Faculty of Medicine, Universidad Complutense de Madrid, Spain.
authors.forename: Tomas
authors.initials: T
authors.lastname: Palomo
authors.affiliation: Department of Psychiatry, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain; Department of Psychiatry, Faculty of Medicine, Universidad Complutense de Madrid, Spain. Electronic address: roberto.rodriguez.jimenez@gmail.com.
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodriguez-Jimenez
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012565:Schizophrenic Psychology; D014706:Verbal Learning; D055815:Young Adult
keywords: Cognition; MCCB; Negative symptoms; PANSS; Psychopathology; Schizophrenia