title: [EFFECT OF MICROSYMBIONTS ON THE ABILITY OF VAGINAL EPITHELIOCYTES TO MODIFY BIOLOGICAL PROPERTIES OF BACTERIA].
abstract: OBJECTIVE
  Study regularities of effects of various types of vaginal microsymbionts on the ability of mucosal epitheliocytes of the vagina to modify biological properties of bacteria.
  
  
  METHODS
  Effect of thermo-inactivated cells of Staphylococcus aureus, Escherichia coli, H2O2-producing and H2O2-non-producing lactobacilli on the ability of primary vaginal epitheliocytes to alter growth and antagonistic activity of Staphylococcus aureus, Escherichia colt, H2O2-producing and H2O2-nonproducing lactobacilli was studied using a multi-component module system.
  
  
  RESULTS
  Alterations of composition of vaginal epitlieliocyte exometabolites under the effect of S. aureus and E. coli was established to result in a pronounced stimulation of antagonistic activity of H2O2-producing and an increase of the number of H2O2-nonproducing lactobacilli. Thermo-inactivated cells of lactobacilli stimulated production of metabolites by epitheliocytes, that suppress the growth and antagonistic activity of allochthonous microflora and stimulate similar parameters of lactobacilli. The strongest effects on the ability of vaginal epitheliocytes to alter biological properties of bacteria were rendered by H2O2-producing lactobacilli.
  
  
  CONCLUSIONS
  The regularities identified allow to examine epitheliocytes and normoflora of vagina as a symbiotic system, the coordinated interaction of its components is directed on maintaining microecological stability of female reproductive tract.
authors.forename: E A
authors.initials: EA
authors.lastname: Kremleva
authors.forename: A V
authors.initials: AV
authors.lastname: Sgibnev
authors.forename: S V
authors.initials: SV
authors.lastname: Cherkasov
mesh_terms: D004847:Epithelial Cells / Q000382:microbiology*; D004926:Escherichia coli / Q000254:growth & development; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007778:Lactobacillus / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000254:growth & development; D013559:Symbiosis; D014621:Vagina / Q000382:microbiology*
chemical_list: D006861:Hydrogen Peroxide