title: Protective effects of isolecanoric acid on neurodegenerative in vitro models.
abstract: Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS), are neurodegenerative disorders characterized by loss of dopaminergic or motor neurons, respectively. Although understanding of the PD and ALS pathogenesis remains incomplete, increasing evidence from human and animal studies has suggested that aberrant GSK3β, oxidative stress and mitochondrial damage are involved in their pathogenesis. Using two different molecular models, treatment with L-BMAA for ALS and rotenone for PD the effect of isolecanoric acid, a natural product isolated from a fungal culture, was evaluated. Pre-treatment with this molecule caused inhibition of GSK3β and CK1, and a decrease in oxidative stress, mitochondrial damage, apoptosis and cell death. Taken together, these results indicated that isolecanoric acid might have a protective effect against the development of these neurodegenerative disorders.
authors.affiliation: Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Avda. Conocimiento 34, 18016 Granada, Spain. Electronic address: nuria.de.pedro@medinaandalucia.es.
authors.forename: Nuria
authors.initials: N
authors.lastname: de Pedro
authors.affiliation: Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Avda. Conocimiento 34, 18016 Granada, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Cantizani
authors.affiliation: Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Avda. Conocimiento 34, 18016 Granada, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Ortiz-López
authors.affiliation: Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Avda. Conocimiento 34, 18016 Granada, Spain.
authors.forename: Victor
authors.initials: V
authors.lastname: González-Menéndez
authors.affiliation: Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Avda. Conocimiento 34, 18016 Granada, Spain.
authors.forename: Bastien
authors.initials: B
authors.lastname: Cautain
authors.affiliation: Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Avda. Conocimiento 34, 18016 Granada, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Rodríguez
authors.affiliation: Texas Therapeutics Institute, University of Texas Health Science Center at Houston, United States.
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Bills
authors.affiliation: Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Avda. Conocimiento 34, 18016 Granada, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Reyes
authors.affiliation: Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Avda. Conocimiento 34, 18016 Granada, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Genilloud
authors.affiliation: Fundación MEDINA, Parque Tecnológico Ciencias de la Salud, Avda. Conocimiento 34, 18016 Granada, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Vicente
mesh_terms: D000599:Amino Acids, Diamino / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D002461:Cell Line, Transformed; D002470:Cell Survival; D000087522:Cyanobacteria Toxins; D004305:Dose-Response Relationship, Drug; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D005434:Flow Cytometry; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D009447:Neuroblastoma / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012459:Salicylates / Q000494:pharmacology*
chemical_list: D000599:Amino Acids, Diamino; D000087522:Cyanobacteria Toxins; D018690:Excitatory Amino Acid Agonists; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D012459:Salicylates; C001824:beta-N-methylamino-L-alanine; C008263:lecanoric acid; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3
keywords: ALS disease; GSK3β; Isolecanoric acid; L-BMAA; Natural products; Neurodegenerative disorders; Parkinson's disease; Rotenone