title: [Study on acute toxicity of outlet water of new technology from a sewage treatment plant in Zhengzhou City].
abstract: OBJECTIVE
  To study the acute toxicity of outlet water of new technology from a sewage treatment plant in Zhengzhou City, and provide scientific basis for safety evaluation of municipal sewage reuse.
  
  
  METHODS
  Based on procedures and tests for toxicological evaluations of chemicals (GBZ/T 240-2011), the acute oral toxicity test, the acute dermal toxicity test, the acute eye irritation test, the skin irritation and sensitization tests were conducted on advanced treatment outlet water.
  
  
  RESULTS
  The LD50 of outlet water of new technology in female mice and male mice were 6810 and 4220 mg/kg BW in the acute oral toxicity test respectively, and the former was actually no grade toxicity, the latter was low grade toxicity. The LD50 in female rats and male rats were 6810 and 5620 mg/kg BW in the acute dermal toxicity test respectively, and both were no grade toxicity. Advanced treatment outlet water could damage the rabbit cornea and conjunctiva differently, IAOI was 28, and MIOI was less than 20 after seven days, so advanced treatment outlet water had middle irritation for the rabbit cornea and conjunctiva. The mean value of skin irritation was 0, so it had no irritation for guinea pigs. The mean value of skin sensitization was 0, so it had no sensitization for guinea pigs.
  
  
  CONCLUSIONS
  Outlet water of new technology is reused by reducing the chances of contracting it with the mouth and eyes, and has no skin irritation and skin sensitization.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Xueqin
authors.initials: X
authors.lastname: Xu
authors.forename: Lanying
authors.initials: L
authors.lastname: Pei
authors.forename: Chunyang
authors.initials: C
authors.lastname: Sun
authors.forename: Guoli
authors.initials: G
authors.lastname: Van
mesh_terms: D000818:Animals; D002947:Cities; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D012722:Sewage / Q000032:analysis*; D012867:Skin; D023382:Toxicity Tests, Acute / Q000379:methods*; D014865:Waste Disposal, Fluid / Q000379:methods*; D014867:Water; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D012722:Sewage; D014874:Water Pollutants, Chemical; D014867:Water