title: Evaluation of the Effect of Modified Bioflavonoid and Quercetin Dihydrate on Cytokine Secretion by Mitogen-Activated Mononuclear Cells.
abstract: An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-γ and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4(+) T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-γ content. The content of IL-17 was shown to decrease above the detection limit.
authors.affiliation: Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: D Z
authors.initials: DZ
authors.lastname: Albegova
authors.affiliation: Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. bigbeaver-90@mail.ru.
authors.forename: O V
authors.initials: OV
authors.lastname: Kamkina
authors.affiliation: I. N. Ulyanov, Chuvash State University, Cheboksary, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Pavlova
authors.affiliation: North Ossetian State Medical Academy, Ministry of Health of the Russian Federation, Vladikavkaz, Russia.
authors.forename: Zh K
authors.initials: ZhK
authors.lastname: Albegova
authors.affiliation: D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Laptev
authors.affiliation: Department of Pharmacology, N. I. Pirogov Russian National Research, Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.|D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
authors.forename: I G
authors.initials: IG
authors.lastname: Kozlov
mesh_terms: D000818:Animals; D002469:Cell Separation; D003208:Concanavalin A / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D006119:Groin; D007371:Interferon-gamma / Q000096:biosynthesis / Q000378:metabolism; D020381:Interleukin-17 / Q000096:biosynthesis / Q000378:metabolism; D007376:Interleukin-2 / Q000096:biosynthesis / Q000378:metabolism; D015850:Interleukin-6 / Q000096:biosynthesis / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000145:classification / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D061251:Primary Cell Culture; D011794:Quercetin / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000276:immunology; D058408:Th1-Th2 Balance / Q000187:drug effects*
chemical_list: D005419:Flavonoids; D020381:Interleukin-17; D007376:Interleukin-2; D015850:Interleukin-6; C577686:interleukin-6, mouse; D003208:Concanavalin A; D007371:Interferon-gamma; D011794:Quercetin
keywords: cytokines; flavonoids; mononuclear cells