title: An update on cell surface proteins containing extensin-motifs.
abstract: In recent years it has become clear that there are several molecular links that interconnect the plant cell surface continuum, which is highly important in many biological processes such as plant growth, development, and interaction with the environment. The plant cell surface continuum can be defined as the space that contains and interlinks the cell wall, plasma membrane and cytoskeleton compartments. In this review, we provide an updated view of cell surface proteins that include modular domains with an extensin (EXT)-motif followed by a cytoplasmic kinase-like domain, known as PERKs (for proline-rich extensin-like receptor kinases); with an EXT-motif and an actin binding domain, known as formins; and with extracellular hybrid-EXTs. We focus our attention on the EXT-motifs with the short sequence Ser-Pro(3-5), which is found in several different protein contexts within the same extracellular space, highlighting a putative conserved structural and functional role. A closer understanding of the dynamic regulation of plant cell surface continuum and its relationship with the downstream signalling cascade is a crucial forthcoming challenge.
authors.affiliation: Fundación Instituto Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, Buenos Aires, C1405BWE, Argentina.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Borassi
authors.affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor Torres (INGEBI-CONICET), Vuelta de Obligado 2490, Buenos Aires, C1428ADN, Argentina.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Sede
authors.affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor Torres (INGEBI-CONICET), Vuelta de Obligado 2490, Buenos Aires, C1428ADN, Argentina.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Mecchia
authors.affiliation: Fundación Instituto Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, Buenos Aires, C1405BWE, Argentina.
authors.forename: Juan D
authors.initials: JD
authors.lastname: Salgado Salter
authors.affiliation: Fundación Instituto Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, Buenos Aires, C1405BWE, Argentina.
authors.forename: Eliana
authors.initials: E
authors.lastname: Marzol
authors.affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor Torres (INGEBI-CONICET), Vuelta de Obligado 2490, Buenos Aires, C1428ADN, Argentina. Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, Ciudad Universitaria, Pabellón II, C1428EGA Buenos Aires, Argentina. prometeo@dna.uba.ar jestevez@leloir.org.ar.
authors.forename: Jorge P
authors.initials: JP
authors.lastname: Muschietti
authors.affiliation: Fundación Instituto Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, Buenos Aires, C1405BWE, Argentina. prometeo@dna.uba.ar jestevez@leloir.org.ar.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Estevez
mesh_terms: D020816:Amino Acid Motifs; D002473:Cell Wall / Q000737:chemistry; D006023:Glycoproteins / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry*; D010940:Plant Proteins / Q000737:chemistry*; D010944:Plants / Q000737:chemistry; D011392:Proline / Q000737:chemistry; D011494:Protein Kinases / Q000737:chemistry
chemical_list: D006023:Glycoproteins; D008565:Membrane Proteins; D010940:Plant Proteins; C005488:extensin protein, plant; D011392:Proline; D011494:Protein Kinases
keywords: Cell surface; PERK; extensin; extensin motif; formin; plant cell wall.