title: The phospholipid code: a key component of dying cell recognition, tumor progression and host-microbe interactions.
abstract: A significant effort is made by the cell to maintain certain phospholipids at specific sites. It is well described that proteins involved in intracellular signaling can be targeted to the plasma membrane and organelles through phospholipid-binding domains. Thus, the accumulation of a specific combination of phospholipids, denoted here as the 'phospholipid code', is key in initiating cellular processes. Interestingly, a variety of extracellular proteins and pathogen-derived proteins can also recognize or modify phospholipids to facilitate the recognition of dying cells, tumorigenesis and host-microbe interactions. In this article, we discuss the importance of the phospholipid code in a range of physiological and pathological processes.
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
authors.forename: A A
authors.initials: AA
authors.lastname: Baxter
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
authors.forename: M D
authors.initials: MD
authors.lastname: Hulett
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
authors.forename: I K H
authors.initials: IK
authors.lastname: Poon
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D018450:Disease Progression; D054884:Host-Pathogen Interactions; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D010743:Phospholipids / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D010743:Phospholipids; D017382:Reactive Oxygen Species