title: Multicomponent Reactions, Union of MCRs and Beyond.
abstract: Multicomponent reactions (MCRs), which are located between one- and two-component and polymerization reactions, provide a number of valuable conceptual and synthetic advantages over stepwise sequential approaches towards complex and valuable molecules. To address current limitations in the number of MCRs and the resulting scaffolds, the concept of union of MCRs was introduced two decades ago by Dömling and Ugi and is rapidly advancing, as is apparent by several recently published works. MCR technology is now widely recognized for its impact on drug discovery projects and is strongly endorsed by industry in addition to academia. Clearly, novel scaffolds accessible in few steps including MCRs will further enhance the field of applications. Additionally, broad expansion of MCR applications in fields such as imaging, materials science, medical devices, agriculture, or futuristic applications in stem cell therapy and theragnostics or solar energy and superconductivity are predicted.
authors.affiliation: Department of Drug Design, University of Groningen, The Netherlands.
authors.forename: Tryfon
authors.initials: T
authors.lastname: Zarganes-Tzitzikas
authors.affiliation: Department of Drug Design, University of Groningen, The Netherlands.
authors.forename: Ajay L
authors.initials: AL
authors.lastname: Chandgude
authors.affiliation: Department of Drug Design, University of Groningen, The Netherlands. a.s.s.domling@rug.nl.
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D058105:Polymerization
chemical_list: D009930:Organic Chemicals; D004364:Pharmaceutical Preparations
keywords: drug discovery; isocyanides; medicinal chemistry; molecular diversity; multicomponent reactions