title: Haploidentical Bone Marrow Transplantation in 2015 and Beyond.
abstract: On the face of the lack of HLA-identical sibling stem cell donors for all individuals needing an allograft, the use of alternative donors is gaining popularity. Matched unrelated donors and cord bloods have become very expensive and unaffordable for most people living in developing countries. Grafting allogeneic haploidentical stem cells has become an option with a great future, mainly if the procedure is conducted in a way to cut down expenses, such as the use of reduced-intensity conditioning regimens, outpatient conduction of the procedures, and use of post-transplant cyclophosphamide. The long-term results of allografting haploidentical stem cells seem to be similar to those of grafting cord blood stem cells. The improvement of the procedures to conduct haploidentical stem cell transplantation will most likely result in more individuals gaining access to this type of treatments, critical in the current practice of hematology.
authors.affiliation: Clínica Ruiz, Centro de Hematologia y Medicina Interna de Puebla, 8B Sur 3710, 72530, Puebla, Mexico. gruiz1@clinicaruiz.com.|Clínica Ruiz, Laboratorios Clínicos de Puebla, Puebla, Mexico. gruiz1@clinicaruiz.com.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico. gruiz1@clinicaruiz.com.|Universidad de las Américas Puebla, Puebla, Mexico. gruiz1@clinicaruiz.com.
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
authors.affiliation: Clínica Ruiz, Centro de Hematologia y Medicina Interna de Puebla, 8B Sur 3710, 72530, Puebla, Mexico.|Clínica Ruiz, Laboratorios Clínicos de Puebla, Puebla, Mexico.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico.|Universidad de las Américas Puebla, Puebla, Mexico.
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Ruiz-Delgado
authors.affiliation: Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
authors.forename: Oscar
authors.initials: O
authors.lastname: González-Llano
authors.affiliation: Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
authors.forename: David
authors.initials: D
authors.lastname: Gómez-Almaguer
mesh_terms: D016026:Bone Marrow Transplantation / Q000379:methods*; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D006680:HLA Antigens / Q000235:genetics; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D035781:Siblings; D013601:T-Lymphocytes / Q000276:immunology; D019172:Transplantation Conditioning / Q000379:methods
chemical_list: D006680:HLA Antigens; D007166:Immunosuppressive Agents
keywords: Allogeneic; Allograft; BMT; Haploidentical