title: [Expression of IFITM3 in colorectal carcinoma and its clinical significance].
abstract: OBJECTIVE
  To investigate the expression of IFITM3 in colorectal carcinoma and its clinical significance.
  
  
  METHODS
  213 patients with colon ademocarcinoma and 214 patients with colon adenoma treated by surgery in our hospital from March 2008 to June 2010 were included in this study. The levels of IFITM3 in normal colon nucosa, adenoma, and adenocarcinoma tissues were detected by real-time PCR and immunochemistry, and its relationship with metastasis and prognosis in 213 colorectal cancer patients was analyzed.
  
  
  RESULTS
  The IFITM3 mRNA level in metastatic tumor group was 18.37 ± 0.61, significantly higher than that in the normal 4.49 ± 0.69 and non-metastases groups (7.32 ± 0.76; F = 460.380, P < 0.001). The positive rate of IFITM3 protein expression in metastatic tumor group (69.0%) was significantly higher than that in the normal (3.9%), non-metastasies groups (19.0%) and adenoma groups (11.3%). Our clinical analysis confirmed that the IFITM3 expression was associated with peritumoral invasion, hepatic metastases, metastases of para-colonic lymph nodes, mesocolonic lymph nodes and mesenteric root lymph nodes, omental metastasis and AJCC classification (P < 0.05). Furthermore, the survival curve analysis showed that patients with lower IFITM3 level expression had a higher 5-year survival rate (88.8%) than that in the patients with higher expression (40.2%, P < 0.001).
  
  
  CONCLUSIONS
  IFITM3 expression has a positive correlation with metastasis and prognosis in patients with colorectal carcinoma.
authors.affiliation: Xinxiang Central Hospital, Xinxiang 453000, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Cui
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.forename: Shoufeng
authors.initials: S
authors.lastname: Zai
authors.affiliation: Email: 1720176340@qq.com.
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism*; D000236:Adenoma; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms; D010534:Peritoneal Neoplasms; D011379:Prognosis; D012333:RNA, Messenger; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D016019:Survival Analysis; D015996:Survival Rate
chemical_list: C080082:IFITM3 protein, human; D008565:Membrane Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins