title: A rare case of regressively changed lipomatous hypertrophy of the interatrial septum presenting with anemia and recurrent fever.
abstract: Lipomatous hypertrophy of the interatrial septum (LHIS) is characterized by excessive accumulation of adipose tissue within some segments of the interatrial septum. Only one published case so far describes fever as a presenting feature of LHIS. On the other hand, systemic symptoms including anemia and fever are well-known clinical presentations of cardiac myxomas. We report an unusual case of a 79-year-old woman who was thoroughly but unsuccessfully investigated for recurrent fever and anemia in several specialized departments over the course of 4 years. Computed tomography scan showed a pathological mass localized in the interatrial septum and spreading to ascending aorta. Histological analysis of the biopsy samples from surgery revealed the unexpected diagnosis of regressively changed LHIS. We discuss the clinical and pathologic features of this lesion suggesting that its regressive changes may be associated with inflammation and can cause systemic symptoms such as fever and anemia.
authors.affiliation: 2nd Department of Medicine-Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rob
authors.affiliation: 2nd Department of Medicine-Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Electronic address: petr.kuchynka@lf1.cuni.cz.
authors.forename: Petr
authors.initials: P
authors.lastname: Kuchynka
authors.affiliation: 2nd Department of Medicine-Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Tomas
authors.initials: T
authors.lastname: Palecek
authors.affiliation: Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Cerny
authors.affiliation: Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Masek
authors.affiliation: Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Ivana
authors.initials: I
authors.lastname: Vitkova
authors.affiliation: 2nd Department of Medicine-Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Rucklova
authors.affiliation: 2nd Department of Medicine-Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Eduard
authors.initials: E
authors.lastname: Nemecek
authors.affiliation: Department of Nuclear Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Zogala
authors.affiliation: 2nd Department of Medicine-Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Ales
authors.initials: A
authors.lastname: Linhart
mesh_terms: D000368:Aged; D000740:Anemia / Q000209:etiology; D054087:Atrial Septum / Q000473:pathology*; D005260:Female; D005334:Fever / Q000209:etiology; D006331:Heart Diseases / Q000150:complications* / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D008068:Lipomatosis / Q000150:complications / Q000473:pathology*
keywords: Anemia; Fever; Inflammation; Lipomatous hypertrophy of the interatrial septum