title: Arterial spin labeling in clinical pediatric imaging.
abstract: Arterial spin labeling (ASL) perfusion-weighted magnetic resonance imaging is the only approach that enables direct and non-invasive quantitative measurement of cerebral blood flow in the brain regions without administration of contrast material and without radiation. ASL is thus a promising perfusion imaging method for assessing cerebral blood flow in the pediatric population. Concerning newborns, there are current limitations because of their smaller brain size and lower brain perfusion. This article reviews and illustrates the use of ASL in pediatric clinical practice and discusses emerging cerebral perfusion imaging applications for children due to the highly convenient implementation of the ASL sequence.
authors.affiliation: Department of Radiology, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France; Inserm VisAGeS unité/projet U746, UMR 6074, Irisa, université Rennes 1, 35043 Rennes cedex, France. Electronic address: maia.proisy@chu-rennes.fr.
authors.forename: M
authors.initials: M
authors.lastname: Proisy
authors.affiliation: Department of Radiology, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: B
authors.initials: B
authors.lastname: Bruneau
authors.affiliation: Department of Radiology, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: C
authors.initials: C
authors.lastname: Rozel
authors.affiliation: Department of Radiology, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: C
authors.initials: C
authors.lastname: Tréguier
authors.affiliation: Department of Radiology, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: K
authors.initials: K
authors.lastname: Chouklati
authors.affiliation: Department of Pediatric Neurosurgery, CHU de Rennes, 2, rue Henri-Le-Guillou, 35033 Rennes cedex 9, France.
authors.forename: L
authors.initials: L
authors.lastname: Riffaud
authors.affiliation: Department of Radiology, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France.
authors.forename: P
authors.initials: P
authors.lastname: Darnault
authors.affiliation: Inserm VisAGeS unité/projet U746, UMR 6074, Irisa, université Rennes 1, 35043 Rennes cedex, France; Department of Radiology, hôpital Pontchaillou, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Ferré
mesh_terms: D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D002648:Child; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D018810:Magnetic Resonance Angiography; D013113:Spin Labels
chemical_list: D013113:Spin Labels
keywords: Arterial spin labeling; Brain perfusion; Children; MRI