title: Efficacy of TachoSil(®) in preventing hemorrhage after loop electrosurgical excision procedure.
abstract: OBJECTIVE
  To assess the utility of TachoSil for achieving hemostasis after loop electrosurgical excision procedure (LEEP).
  
  
  METHODS
  Case-control study (Canadian Task Force Classification II-2).
  
  
  METHODS
  University hospital.
  
  
  METHODS
  One hundred seventy-three patients who underwent LEEP.
  
  
  METHODS
  Patients were managed by LEEP with application of TachoSil (TachoSil group, n=75) or without application of TachoSil (control group, n=94).
  
  
  RESULTS
  Patient characteristics (age, specimen depth, resection margin, LEEP histopathology, or use of TachoSil) except for parity were similar between the two study groups. Severe bleeding requiring any intervention developed in 14% of patients (24 of 169 patients), without any statistically significant difference between the two groups (11% in the TachoSil group vs. 17% in the control group; P=0.274). On the logistic regression analysis, other potential clinico-pathologic parameters, including age, parity, specimen depth, involvement of the resection margin, and LEEP histopathology, were not correlated with severe bleeding after LEEP.
  
  
  CONCLUSIONS
  The use of TachoSil may not reduce the incidence of severe bleeding after LEEP.
authors.affiliation: Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Jeong Jin
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Woo Young
authors.initials: WY
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Doo Haeng
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Jun Hyeok
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: taejong.song@gmail.com.
authors.forename: Taejong
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Kyo Won
authors.initials: KW
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Kye Hyun
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004338:Drug Combinations; D004598:Electrosurgery / Q000009:adverse effects*; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use*; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D012189:Retrospective Studies; D015503:Surgical Sponges; D013917:Thrombin / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*
chemical_list: D004338:Drug Combinations; C518955:TachoSil; D005340:Fibrinogen; D013917:Thrombin
keywords: Bleeding; Fibrin sealant; Hemorrhage; LEEP; TachoSil