title: Integrative neuroscience approach to neuropsychiatric lupus.
abstract: We present a succinct review of our approach to study the interactions between the DNA-reactive antibodies that cross-react with the GluN2A and GluN2B subunits of the N-methyl-D-aspartate receptor, denoted DNRABs, and their brain targets in subjects with neuropsychiatric systemic lupus erythematosus (NPSLE). We have analyzed the DNRAB-based brain symptomatology in mouse models of NPSLE by using an integrative neuroscience approach, which includes behavioral assessment coupled with electrophysiological studies of neural networks and synaptic connections in target brain regions, such as the CA1 region of the hippocampus. Our results suggest a framework for understanding the interactions between immune factors and neural networks.
authors.affiliation: Laboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA. pato.huerta@gmail.com.|Department of Molecular Medicine, Hofstra North Shore LIJ Medical School, Hempstead, NY, USA. pato.huerta@gmail.com.
authors.forename: Patricio T
authors.initials: PT
authors.lastname: Huerta
authors.affiliation: Laboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Gibson
authors.affiliation: Laboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
authors.forename: Carson
authors.initials: C
authors.lastname: Rey
authors.affiliation: Laboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
authors.forename: Tomás S
authors.initials: TS
authors.lastname: Huerta
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000378:metabolism*; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D003072:Cognition Disorders / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D009415:Nerve Net / Q000502:physiology*; D015213:Neuroimmunomodulation; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology / Q000378:metabolism*
chemical_list: D000974:Antibodies, Antinuclear; D016194:Receptors, N-Methyl-D-Aspartate; C121001:NR2B NMDA receptor
keywords: Brain autoimmunity; Cognition; Hippocampus; Mouse; NMDAR