title: Recent advances in dengue pathogenesis and clinical management.
abstract: This review describes and commentates on recent advances in the understanding of dengue pathogenesis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in dengue virus infection, the contribution of cellular and humoral immune responses to pathogenesis and immunity, NS1 and mechanisms of virus immune evasion. Additionally we review a series of therapeutic intervention trials for dengue, as well as recent clinical research aimed at improving clinical diagnosis, risk prediction and disease classification.
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Vo Van Kiet street, District 5, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: csimmons@oucru.org.
authors.forename: Cameron P
authors.initials: CP
authors.lastname: Simmons
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Kirsty
authors.initials: K
authors.lastname: McPherson
authors.affiliation: Hospital for Tropical Diseases, 764 Vo Van Kiet, District 5, Ho Chi Minh City, Viet Nam.
authors.forename: Nguyen
authors.initials: N
authors.lastname: Van Vinh Chau
authors.affiliation: University of Medicine and Pharmacy, 217 Hong Bang, District 5, Ho Chi Minh City, Viet Nam.
authors.forename: D T
authors.initials: DT
authors.lastname: Hoai Tam
authors.affiliation: School of Chemistry and Molecular Biosciences, University of Queensland, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Young
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Jason
authors.initials: J
authors.lastname: Mackenzie
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Vo Van Kiet street, District 5, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Bridget
authors.initials: B
authors.lastname: Wills
mesh_terms: D056704:Adaptive Immunity; D003715:Dengue / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D003955:Diagnostic Tests, Routine; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007113:Immunity, Innate; D007167:Immunotherapy / Q000379:methods / Q000639:trends
keywords: Clinical research; Dengue; Immunology; Pathogenesis; Vaccine; Virology