title: Resistance Training and White Matter Lesion Progression in Older Women: Exploratory Analysis of a 12-Month Randomized Controlled Trial.
abstract: OBJECTIVE
  To assess whether resistance training (RT) slows the progression of white matter lesions (WMLs) in older women.
  
  
  METHODS
  Secondary analysis of a 52-week randomized controlled trial of RT, the Brain Power Study.
  
  
  METHODS
  Community center and research center.
  
  
  METHODS
  Of 155 community-dwelling women aged 65 to 75 enrolled in the Brain Power Study, 54 who had evidence of WMLs on magnetic resonance imaging (MRI) at baseline were included in this secondary analysis.
  
  
  METHODS
  Participants were randomized to once-weekly RT (1× RT), twice-weekly RT (2× RT), or twice-weekly balance and tone (BAT). Assessors were blinded to participant assignments.
  
  
  METHODS
  WML volume was measured using MRI at baseline and trial completion.
  
  
  RESULTS
  At trial completion, the 2× RT group had significantly lower WML volume than the BAT group (P = .03). There was no significant difference between the BAT group and the 1× RT group at trial completion (P = .77). Among participants in the two RT groups, reduced WML progression over 12 months was significantly associated with maintenance of gait speed (correlation coefficient (r) = -0.31, P = .049) but not with executive functions (r = 0.30; P = .06).
  
  
  CONCLUSIONS
  Engaging in progressive RT may reduce WML progression.
authors.affiliation: Aging, Mobility and Cognitive Neuroscience Laboratory, University of British Columbia, Vancouver, British Columbia, Canada.|Experimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada.|Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.|Centre for Hip Health and Mobility, University of British Columbia, Vancouver, British Columbia, Canada.|Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
authors.forename: Niousha
authors.initials: N
authors.lastname: Bolandzadeh
authors.affiliation: Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Roger
authors.initials: R
authors.lastname: Tam
authors.affiliation: Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Handy
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois.
authors.forename: Lindsay S
authors.initials: LS
authors.lastname: Nagamatsu
authors.affiliation: Aging, Mobility and Cognitive Neuroscience Laboratory, University of British Columbia, Vancouver, British Columbia, Canada.|Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.|Centre for Hip Health and Mobility, University of British Columbia, Vancouver, British Columbia, Canada.|Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
authors.forename: Chun Liang
authors.initials: CL
authors.lastname: Hsu
authors.affiliation: Aging, Mobility and Cognitive Neuroscience Laboratory, University of British Columbia, Vancouver, British Columbia, Canada.|Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.|School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.|Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Davis
authors.affiliation: Aging, Mobility and Cognitive Neuroscience Laboratory, University of British Columbia, Vancouver, British Columbia, Canada.|Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.|Centre for Hip Health and Mobility, University of British Columbia, Vancouver, British Columbia, Canada.|Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Dao
authors.affiliation: Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.|Division of Geriatric Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: B Lynn
authors.initials: BL
authors.lastname: Beattie
authors.affiliation: Aging, Mobility and Cognitive Neuroscience Laboratory, University of British Columbia, Vancouver, British Columbia, Canada.|Experimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada.|Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.|Centre for Hip Health and Mobility, University of British Columbia, Vancouver, British Columbia, Canada.|Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
authors.forename: Teresa
authors.initials: T
authors.lastname: Liu-Ambrose
mesh_terms: D000368:Aged; D018450:Disease Progression; D056344:Executive Function; D005260:Female; D005684:Gait; D006801:Humans; D008279:Magnetic Resonance Imaging; D011446:Prospective Studies; D055070:Resistance Training / Q000379:methods* / Q000706:statistics & numerical data; D016037:Single-Blind Method; D066127:White Matter / Q000473:pathology*
keywords: magnetic resonance imaging; resistance training; white matter lesions