title: Formulation and development of orodispersible sustained release tablet of domperidone.
abstract: Commercially available domperidone orodispersible tablets (ODT) are intended for immediate release of the drug, but none of them have been formulated for sustained action. The aim of the present research work was to develop and evaluate orodispersible sustained release tablet (ODT-SR) of domperidone, which has the convenience of ODT and benefits of controlled release product combined in one. The technology comprised of developing sustained release microspheres (MS) of domperidone, followed by direct compression of MS along with suitable excipients to yield ODT-SR which rapidly disperses within 30 seconds and yet the dispersed MS maintain their integrity to have a sustained drug release. The particle size of the MS was optimized to be less than 200 μm to avoid the grittiness in the mouth. The DSC thermograms of MS showed the absence of drug-polymer interaction within the microparticles, while SEM confirmed their spherical shape and porous nature. Angle of repose, compressibility and Hausner's ratio of the blend for compression showed good flowability and high percent compressibility. The optimized ODT-SR showed disintegration time of 21 seconds and matrix controlled drug release for 9 h. In-vivo pharmacokinetic studies in Wistar rats showed that the ODT-SR had a prolonged MRT of 11.16 h as compared 3.86 h of conventional tablet. The developed technology is easily scalable and holds potential for commercial exploitation.
authors.affiliation: a C.U. Shah College of Pharmacy, SNDT Women's University , Mumbai , Maharashta , India .
authors.forename: Hemlata G
authors.initials: HG
authors.lastname: Patil
authors.affiliation: b Department of Pharmaceutics & Drug Delivery , University of Mississippi , University , MS , USA , and.
authors.forename: Roshan V
authors.initials: RV
authors.lastname: Tiwari
authors.affiliation: b Department of Pharmaceutics & Drug Delivery , University of Mississippi , University , MS , USA , and.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Repka
authors.affiliation: a C.U. Shah College of Pharmacy, SNDT Women's University , Mumbai , Maharashta , India .|c School of Pharmacy and Biomedical Sciences, University of Central Lancashire , Preston , UK.
authors.forename: Kamalinder K
authors.initials: KK
authors.lastname: Singh
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004294:Domperidone / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry; D006244:Hardness; D008863:Microspheres; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D005079:Excipients; D011108:Polymers; D013607:Tablets; D004294:Domperidone
keywords: Antiemetic; microspheres; orodispersible tablet; sustained release