title: Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation.
abstract: Current medicines for the clinical management of inflammatory diseases act by inhibiting specific enzymes or antagonising specific receptors or blocking their ligands. In the past decade, a new paradigm in our understanding of the inflammatory process has emerged with the appreciation of genetic, molecular, and cellular mechanisms that are engaged to actively resolve inflammation. The 'resolution of acute inflammation' is enabled by counter-regulatory checkpoints to terminate the inflammatory reaction, promoting healing and repair. It may be possible to harness this knowledge for innovative approaches to the treatment of inflammatory pathologies. Here we discuss current translational attempts to develop agonists at proresolving targets as a strategy to rectify chronic inflammatory status. We reason this new approach will lead to the identification of better drugs that will establish a new branch of pharmacology, 'resolution pharmacology'.
authors.affiliation: William Harvey Research Institute, Queen Mary University of London, London, UK. Electronic address: m.perretti@qmul.ac.uk.
authors.forename: Mauro
authors.initials: M
authors.lastname: Perretti
authors.affiliation: Drug Discovery Biology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.affiliation: Queen Mary Innovation Ltd, London, UK.
authors.forename: Elliot J
authors.initials: EJ
authors.lastname: Bland
authors.affiliation: William Harvey Research Institute, Queen Mary University of London, London, UK.
authors.forename: Trinidad
authors.initials: T
authors.lastname: Montero-Melendez
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators