title: Genitourinary manifestations of sickle cell disease.
abstract: Sickle cell disease is a common genetic disorder characterized by sickling of red blood cells under conditions of reduced oxygen tension. In turn, sickling leads to intravascular hemolysis and vaso-occlusive events with subsequent tissue ischemia-reperfusion injury affecting multiple organs, including the genitourinary system. Our review of the genitourinary manifestations of sickle cell disease focuses on sickle cell nephropathy, priapism, and other genitourinary complications such as papillary necrosis and renal medullary carcinoma.
authors.affiliation: Transplant Center, Cleveland Clinic Florida, Weston, FL, USA.|Assistant Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Surafel
authors.initials: S
authors.lastname: Gebreselassie
authors.affiliation: Urology Specialists of Oregon, Bend, OR, USA.
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Simmons
authors.affiliation: Center for Genitourinary Reconstruction, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA. E-mail: montagd@ccf.org.|Professor of Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.|former Chair, American Urological Association Erectile Dysfunction Guideline Update Panel.
authors.forename: Drogo K
authors.initials: DK
authors.lastname: Montague
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000628:therapy; D007674:Kidney Diseases / Q000209:etiology / Q000628:therapy; D007679:Kidney Medulla; D007680:Kidney Neoplasms / Q000209:etiology* / Q000628:therapy; D007681:Kidney Papillary Necrosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D010413:Penis / Q000098:blood supply; D011317:Priapism / Q000209:etiology* / Q000628:therapy