title: Radiotherapy combined docetaxel and oxaliplatin chemotherapy is effective in patients with locally advanced nasopharyngeal carcinoma.
abstract: The outcome of locoregionally advanced nasopharyngeal carcinoma (NPC) remains unsatisfactory due to high rates of local and distant failure, and the best way of integration of chemotherapy to chemoradiotherapy was still undefined. The aim of this study was to evaluate the efficacy of radiotherapy combined docetaxel and oxaliplatin (TP) chemotherapy in patients with locally advanced NPC. A total of 62 patients in stages III-IVA with a newly diagnosed and previously untreated NPC were enrolled in this study. All patients received 70-74 Gy in 7 weeks using standard intensity-modulated radiotherapy (IMRT) portals and techniques. A combination of TP chemotherapy were used every 3 weeks for two cycles before and after IMRT. Response analysis including toxicities, efficacy and survival were made 3 months after termination of radiotherapy. No grade 5 toxicity (death) occurred during treatment, and the most common grade 3 hematologic toxicities during chemotherapy were neutropenia (37.1 %), thrombocytopenia (4.8 %) and anemia (4.8 %). The progression free survival rate of 1- , 3- and 5-year were 96.8, 75.8 and 64.5 %, respectively. The overall survival rate of 1- , 3- and 5-year were 100, 82.3 and 75.8 %, respectively. Our findings suggest that induction chemotherapy of TP to IMRT may provide potential improvement of tumor control probability for advanced NPC.
authors.affiliation: Department of Oncology, Southwest Cancer Center, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Main Street, Shapingba District, Chongqing, 400038, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Pan
authors.affiliation: Department of Oncology, Southwest Cancer Center, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Main Street, Shapingba District, Chongqing, 400038, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Ruan
authors.affiliation: Department of Oncology, Southwest Cancer Center, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Main Street, Shapingba District, Chongqing, 400038, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Oncology, Southwest Cancer Center, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Main Street, Shapingba District, Chongqing, 400038, China.
authors.forename: Xueli
authors.initials: X
authors.lastname: Pang
authors.affiliation: Department of Oncology, Southwest Cancer Center, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Main Street, Shapingba District, Chongqing, 400038, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Southwest Cancer Center, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Main Street, Shapingba District, Chongqing, 400038, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zou
authors.affiliation: Department of Oncology, Southwest Cancer Center, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Main Street, Shapingba District, Chongqing, 400038, China. lianghoujie@sina.com.
authors.forename: Houjie
authors.initials: H
authors.lastname: Liang
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002277:Carcinoma; D059248:Chemoradiotherapy / Q000379:methods* / Q000401:mortality; D000077143:Docetaxel; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D009944:Organoplatinum Compounds / Q000008:administration & dosage*; D000077150:Oxaliplatin; D015996:Survival Rate / Q000639:trends; D043823:Taxoids / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009944:Organoplatinum Compounds; D043823:Taxoids; D000077150:Oxaliplatin; D000077143:Docetaxel
keywords: Chemoradiotherapy; Docetaxel; Nasopharyngeal carcinoma; Oxaliplatin