title: Pediatric Disseminated Lemierre Syndrome in 2 Infants: Not Too Young for an Ancient Disease.
abstract: The Lemierre syndrome is characterized by an oropharyngeal infection, thrombosis of the internal jugular vein, and multiple septic metastases. Fusobacterium necrophorum is a common cause of it. The incidence is 0.6 to 2.3 cases per million with a mortality rate of 4% to 18%. Its fast evolution and the possibility of severe complications require a high index of suspicion for its diagnosis. We present 2 infants with Lemierre syndrome. The younger case, a 6-month-old infant, was fully recovered. In the other side, and despite an aggressive therapy, an 18-month-old infant developed cerebral palsy. We also provide a short literature review with a focus on clinical presentation and differential diagnosis in order to initiate an early and adequate therapy.
authors.affiliation: From the Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: García-Salido
authors.forename: José Luis
authors.initials: JL
authors.lastname: Unzueta-Roch
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: García-Teresa
authors.forename: Sara
authors.initials: S
authors.lastname: Sirvent-Cerdá
authors.forename: Amelia
authors.initials: A
authors.lastname: Martínez de Azagra-Garde
authors.forename: Juan
authors.initials: J
authors.lastname: Casado-Flores
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D005675:Fusobacterium necrophorum; D006801:Humans; D007223:Infant; D057831:Lemierre Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents