title: Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APC (Min/+) Intestinal Polyposis Model.
abstract: BACKGROUND
  Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was to investigate the effects of an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis.
  
  
  METHODS
  Apc (Min/+) mice were fed a diet of 0.2% or 0.5% AE for 7 weeks. We analyzed the number of intestinal tumors, oxidative stress and inflammatory markers associated with β-catenin and cytosolic phospholipase A2 (cPLA2) signals. The number of intestinal tumors, and cellular expression of β-catenin were determined.
  
  
  RESULTS
  The number of intestinal tumors was significantly lower in mice fed a 0.5% AE diet compared to those of the other groups. Cytosolic β-catenin expression was significantly decreased in the AE supplemented groups compared to that of the control animals. In addition, mucosa expression of cyclooxygenase-2 and cPLA2 were also significantly decreased in the 0.5% AE group, by 32% and 62%, respectively, compared to the control group.
  
  
  CONCLUSIONS
  These results suggest that dietary AE reduced the development of intestinal tumors, possibly through the ability to suppress oxidative stresses, decreasing inflammatory responses mediated by β-catenin associated signals.
authors.affiliation: Department of Food and Nutrition Education, Graduate School of Education, Soonchunhyang University, Asan, Korea.
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Park
authors.affiliation: Department of Food and Nutrition Education, Graduate School of Education, Soonchunhyang University, Asan, Korea.
authors.forename: Jung-Mi
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Food and Nutrition Education, Graduate School of Education, Soonchunhyang University, Asan, Korea.
authors.forename: Jong-Sang
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Food and Nutrition Education, Graduate School of Education, Soonchunhyang University, Asan, Korea.
authors.forename: Myoung-Gun
authors.initials: MG
authors.lastname: Choung
authors.affiliation: Department of Food and Nutrition Education, Graduate School of Education, Soonchunhyang University, Asan, Korea.
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Sung
keywords: APCMin/+; Anthocyanins; Black soybean; Inflammation; Intestinal tumors