title: Mechanisms of obesity in the development of breast cancer.
abstract: Preclinical models and clinical retrospective data indicate that obesity is associated with a significant increase in the incidence, severity, and mortality from different types of cancer, including postmenopausal breast cancer. As discussed in the present review, both soluble factors and cellular players are involved in the mechanisms promoting local and metastatic breast cancer progression by adipose tissue. As the incidence of obesity is increasing worldwide, there is an urgent need for adequate preclinical models and preclinical and clinical studies designed to investigate how to inhibit the tumor-promoting activity of the adipose tissue.
authors.affiliation: Laboratory of Hematology-Oncology, European Institute of Oncology, Milan, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Orecchioni
authors.affiliation: Laboratory of Hematology-Oncology, European Institute of Oncology, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Reggiani
authors.affiliation: Laboratory of Hematology-Oncology, European Institute of Oncology, Milan, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Talarico
authors.affiliation: Laboratory of Hematology-Oncology, European Institute of Oncology, Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertolini
mesh_terms: D017667:Adipocytes / Q000166:cytology; D000273:Adipose Tissue / Q000166:cytology / Q000473:pathology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D015994:Incidence; D008214:Lymphocytes / Q000166:cytology; D008687:Metformin / Q000627:therapeutic use; D022423:Myeloid Cells / Q000166:cytology; D009765:Obesity / Q000150:complications* / Q000473:pathology*; D013234:Stem Cells / Q000166:cytology; D059016:Tumor Microenvironment; D015431:Weight Loss
chemical_list: D000893:Anti-Inflammatory Agents; D008687:Metformin