title: Metabolic Profile and Inflammatory Responses in Dairy Cows with Left Displaced Abomasum Kept under Small-Scaled Farm Conditions.
abstract: Left displaced abomasum (LDA) is a severe metabolic disease of cattle with a strong negative impact on production efficiency of dairy farms. Metabolic and inflammatory alterations associated with this disease have been reported in earlier studies, conducted mostly in large dairy farms. This research aimed to: (1) evaluate metabolic and inflammatory responses in dairy cows affected by LDA in small-scaled dairy farms; and (2) establish an Animals 2015, 5 1022 association between lactation number and milk production with the outcome of metabolic variables. The cows with LDA had lower serum calcium (Ca), but greater concentrations of non-esterified fatty acids (NEFA) and beta-hydroxy-butyrate (BHBA), in particular when lactation number was >2. Cows with LDA showed elevated levels of aspartate aminotransferase, glutamate dehydrogenase, and serum amyloid A (SAA), regardless of lactation number. In addition, this study revealed strong associations between milk yield and the alteration of metabolic profile but not with inflammation in the sick cows. Results indicate metabolic alterations, liver damage, and inflammation in LDA cows kept under small-scale farm conditions. Furthermore, the data suggest exacerbation of metabolic profile and Ca metabolism but not of inflammation and liver health with increasing lactation number and milk yield in cows affected by LDA.
authors.affiliation: Department of Farm Animals and Veterinary Public Health, Institute of Animal Nutrition and Functional Plant Compounds, Vetmeduni Vienna, Veterinaerplatz 1, Vienna 1210, Austria. fenjaklevenhusen@aol.com.
authors.forename: Fenja
authors.initials: F
authors.lastname: Klevenhusen
authors.affiliation: Department of Farm Animals and Veterinary Public Health, Institute of Animal Nutrition and Functional Plant Compounds, Vetmeduni Vienna, Veterinaerplatz 1, Vienna 1210, Austria. elke.humer@vetmeduni.ac.at.
authors.forename: Elke
authors.initials: E
authors.lastname: Humer
authors.affiliation: Department of Farm Animals and Veterinary Public Health, University Clinic for Swine, Vetmeduni Vienna, Veterinaerplatz 1, Vienna 1210, Austria. barbara.metzler@vetmeduni.ac.at.
authors.forename: Barbara
authors.initials: B
authors.lastname: Metzler-Zebeli
authors.affiliation: Veterinary Clinic Dr. Leopold Podstatzky-Lichtenstein, Wels 4600, Austria. leopold.podstatzky@raumberg-gumpenstein.at.
authors.forename: Leopold
authors.initials: L
authors.lastname: Podstatzky-Lichtenstein
authors.affiliation: Department of Farm Animals and Veterinary Public Health, University Clinic for Ruminants, Vetmeduni Vienna, Veterinaerplatz 1, 1210 Vienna, Austria. thomas.wittek@vetmeduni.ac.at.
authors.forename: Thomas
authors.initials: T
authors.lastname: Wittek
authors.affiliation: Department of Farm Animals and Veterinary Public Health, Institute of Animal Nutrition and Functional Plant Compounds, Vetmeduni Vienna, Veterinaerplatz 1, Vienna 1210, Austria. qendrim.zebeli@vetmeduni.ac.at.
authors.forename: Qendrim
authors.initials: Q
authors.lastname: Zebeli
keywords: acute phase response; cow welfare; metabolic disease; milk yield; periparturient dairy cow