title: Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene.
abstract: BACKGROUND
  This study aimed to determine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery total score diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and dementia in familial Alzheimer's disease (FAD) with E280A mutation on presenilin-1 gene (PSEN1).
  
  
  METHODS
  A cross-sectional study was conducted in a cohort of PSEN1 E280A carriers and non-carriers assessed between January 1995 and February 2013. During the first neuropsychological assessment, 76 were having dementia, 46 had MCI, and 1,576 were asymptomatic. CERAD cut-off points were established for MCI and dementia using a Receiver Operating Characteristics (ROC) analysis, and were further analyzed according to education level in two groups: low education level (eight years or less), and high education level (over eight years).
  
  
  RESULTS
  The area under curve-ROC CERAD total score for dementia was 0.994 (95% CI = 0.989-0.999), and that for MCI was 0.862 (95% CI = 0.816-0.908). The dementia diagnosis cut-off point for the low education group was 54, (98.4% sensitivity, 92.6% specificity), and that for the high education group was 67 (100% sensitivity, 94.1% specificity). The MCI diagnosis cut-off point for the low education group was 66 (91.2% sensitivity, 56.4% specificity), and that for the high education group was 72 (91.7% sensitivity, 76.3% specificity).
  
  
  CONCLUSIONS
  The CERAD total score is a useful screening tool for dementia and MCI in a population at risk of FAD.
authors.affiliation: Grupo de Neurociencias de Antioquia,Grupo Académico de Epidemiología Clínica,School of Medicine,Medical Research Institute,University of Antioquia,Medellín,Colombia.
authors.forename: Daniel Camilo
authors.initials: DC
authors.lastname: Aguirre-Acevedo
authors.affiliation: Grupo Académico de Epidemiología Clínica and Research Unit,Hospital Pablo Tobón Uribe,School of Medicine,University of Antioquia,Hospital Pablo Tobón Uribe,Medellín,Colombia.
authors.forename: Fabian
authors.initials: F
authors.lastname: Jaimes-Barragán
authors.affiliation: Grupo de Neurociencias de Antioquia,School of Medicine,University of Antioquia,Medellín,Colombia.
authors.forename: Eliana
authors.initials: E
authors.lastname: Henao
authors.affiliation: Grupo de Neurociencias de Antioquia,School of Medicine,University of Antioquia,Medellín,Colombia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Tirado
authors.affiliation: Grupo de Neurociencias de Antioquia,School of Medicine,University of Antioquia,Medellín,Colombia.
authors.forename: Claudia
authors.initials: C
authors.lastname: Muñoz
authors.affiliation: Banner Alzheimer's Institute,Arizona,USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Reiman
authors.affiliation: Banner Alzheimer's Institute,Arizona,USA.
authors.forename: Pierre N
authors.initials: PN
authors.lastname: Tariot
authors.affiliation: Banner Alzheimer's Institute,Arizona,USA.
authors.forename: Jessica B
authors.initials: JB
authors.lastname: Langbaum
authors.affiliation: Grupo de Neurociencias de Antioquia,School of Medicine,University of Antioquia,Medellín,Colombia.
authors.forename: Francisco
authors.identifier: http://orcid.org/0000-0003-3986-1484
authors.initials: F
authors.lastname: Lopera
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics*; D000647:Amnesia / Q000175:diagnosis; D019540:Area Under Curve; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000208:ethnology; D003105:Colombia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009483:Neuropsychological Tests / Q000592:standards*; D053764:Presenilin-1 / Q000235:genetics*; D021641:Recognition, Psychology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D005819:Genetic Markers; C508853:PSEN1 protein, human; D053764:Presenilin-1
keywords: Alzheimer's disease; CERAD; mild cognitive impairment; sensitivity; validity