title: Waterborne Risperidone Decreases Stress Response in Zebrafish.
abstract: The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.
authors.affiliation: Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil; Laboratório de Fisiologia de Peixes, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil.
authors.forename: Renan
authors.initials: R
authors.lastname: Idalencio
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Kalichak
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors.forename: João Gabriel Santos
authors.initials: JG
authors.lastname: Rosa
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors.forename: Tiago Acosta
authors.initials: TA
authors.lastname: de Oliveira
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors.forename: Gessi
authors.initials: G
authors.lastname: Koakoski
authors.affiliation: Laboratório de Fisiologia de Peixes, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil.
authors.forename: Darlan
authors.initials: D
authors.lastname: Gusso
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors.forename: Murilo Sander de
authors.initials: MS
authors.lastname: Abreu
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors.forename: Ana Cristina Varrone
authors.initials: AC
authors.lastname: Giacomini
authors.affiliation: Laboratório de Fisiologia de Peixes, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors.forename: Heloísa Helena de Alcântara
authors.initials: HH
authors.lastname: Barcellos
authors.affiliation: Laboratório de Psicofarmacologia e Comportamento (LAPCOM), Programa de Pós-Graduação em Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
authors.forename: Angelo L
authors.initials: AL
authors.lastname: Piato
authors.affiliation: Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil; Laboratório de Fisiologia de Peixes, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil.
authors.forename: Leonardo José Gil
authors.initials: LJ
authors.lastname: Barcellos
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism* / Q000473:pathology; D010913:Pituitary-Adrenal System / Q000378:metabolism* / Q000473:pathology; D018967:Risperidone / Q000009:adverse effects* / Q000494:pharmacology; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000494:pharmacology; D015027:Zebrafish / Q000378:metabolism*
chemical_list: D014151:Anti-Anxiety Agents; D014874:Water Pollutants, Chemical; D018967:Risperidone