title: Immune reactivity in rats selected for the enhancement or elimination of aggressiveness towards humans.
abstract: This study analyzes immune reactivity in two lines of rats selected for the enhancement or elimination of aggressiveness toward humans. Compared to nonaggressive line, aggressive rats showed increased blood ratio of CD4(+) and CD8(+)T lymphocytes, monocyte chemoattractant protein (MCP)-1 level both before and after immunization with sheep red blood cells (SRBC), enhanced IgM-immune response, as well as decreased level of interleukin (IL)-1α before immunization. However, antigen administration produced IL-1α increase in aggressive rats and its decrease in nonaggressive rats compared to non-immunized rats of the same lines. In addition, line-dependent alterations of T lymphocyte distribution in response to immune activation have been found only in the spleen. It is suggested that genetic differences in aggressive behavior may contribute to differences in immune function.
authors.affiliation: Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and Basic Medicine", Timakova Street, 4, Novosibirsk, Russia; Novosibirsk State University, Pirogova Street, 2, 630090 Novosibirsk, Russia. Electronic address: galina@physiol.ru.
authors.forename: Galina
authors.initials: G
authors.lastname: Idova
authors.affiliation: Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and Basic Medicine", Timakova Street, 4, Novosibirsk, Russia.
authors.forename: Elizaveta
authors.initials: E
authors.lastname: Alperina
authors.affiliation: Federal Research Center "Institute of Cytology and Genetics", Siberian Branch of the Russian Academy of Sciences, Lavrentyev Avenue, 10, 630090 Novosibirsk, Russia; Novosibirsk State University, Pirogova Street, 2, 630090 Novosibirsk, Russia.
authors.forename: Irina
authors.initials: I
authors.lastname: Plyusnina
authors.affiliation: Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and Basic Medicine", Timakova Street, 4, Novosibirsk, Russia.
authors.forename: Margarita
authors.initials: M
authors.lastname: Gevorgyan
authors.affiliation: Federal State Budgetary Scientific Institution "Scientific Research Institute of Physiology and Basic Medicine", Timakova Street, 4, Novosibirsk, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Zhukova
authors.affiliation: Novosibirsk State University, Pirogova Street, 2, 630090 Novosibirsk, Russia.
authors.forename: Maria
authors.initials: M
authors.lastname: Konoshenko
authors.affiliation: Federal Research Center "Institute of Cytology and Genetics", Siberian Branch of the Russian Academy of Sciences, Lavrentyev Avenue, 10, 630090 Novosibirsk, Russia; Novosibirsk State University, Pirogova Street, 2, 630090 Novosibirsk, Russia.
authors.forename: Rimma
authors.initials: R
authors.lastname: Kozhemyakina
authors.affiliation: College of Medicine, Chang-Gung University, N. 259, Wen-Hwa1st Road, Kwei-Shan, Taoyuan City 333, Taiwan, ROC.
authors.forename: Wang
authors.initials: W
authors.lastname: Shui-Wu
mesh_terms: D000374:Aggression; D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007114:Immunization; D007075:Immunoglobulin M / Q000097:blood; D053582:Interleukin-1alpha / Q000097:blood; D009929:Organ Size; D051381:Rats; D012756:Sheep; D013045:Species Specificity; D013154:Spleen / Q000033:anatomy & histology / Q000166:cytology / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000033:anatomy & histology / Q000166:cytology / Q000276:immunology*
chemical_list: D007075:Immunoglobulin M; D053582:Interleukin-1alpha
keywords: Aggressive and nonaggressive rats; IL-1α; IgM-immune response; МСР-1; Т lymphocyte subpopulations