title: Novel Imaging Markers of Ischemic Cerebral Edema and Its Association with Neurological Outcome.
abstract: Ischemic cerebral edema (ICE) is a recognized cause of secondary neurological deterioration after large hemispheric stroke, but little is known about the scope of its impact. To study edema in less severe stroke, our group has developed several markers of cerebral edema using brain magnetic resonance imaging (MRI). These tools, which are based on categorical and volumetric measurements in serial diffusion-weighted imaging (DWI), are applicable to a wide variety of stroke volumes. Further, these metrics provide distinct volumetric measurements attributable to ICE, infarct growth, and hemorrhagic transformation. We previously reported that ICE independently predicted neurological outcome after adjustment for known risk factors. We found that an ICE volume of 11 mL or greater was associated with worse neurological outcome.
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Lunder 644, 55 Fruit Street, Boston, MA, 02114, USA. wtkimberly@mgh.harvard.edu.
authors.forename: W Taylor
authors.initials: WT
authors.lastname: Kimberly
authors.affiliation: Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA.
authors.forename: Thomas W K
authors.initials: TW
authors.lastname: Battey
authors.affiliation: Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA.
authors.forename: Ona
authors.initials: O
authors.lastname: Wu
authors.affiliation: Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA.
authors.forename: Aneesh B
authors.initials: AB
authors.lastname: Singhal
authors.affiliation: Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Bruce C V
authors.initials: BC
authors.lastname: Campbell
authors.affiliation: Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Davis
authors.affiliation: Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Donnan
authors.affiliation: Department of Neurology, Yale New Haven Hospital, New Haven, CT, USA.
authors.forename: Kevin N
authors.initials: KN
authors.lastname: Sheth
mesh_terms: D001929:Brain Edema / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D011379:Prognosis; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology