title: Helicobacter pylori virulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease.
abstract: Helicobacter pylori infection plays an important role in the pathogenesis of peptic ulcer disease (PUD). Several factors have been proposed as possible H. pylori virulence determinants; for example, bacterial adhesins and gastric inflammation factors are associated with an increased risk of PUD. However, differences in bacterial virulence factors alone cannot explain the opposite ends of the PUD disease spectrum, that is duodenal and gastric ulcers; presumably, both bacterial and host factors contribute to the differential response. Carriers of the high-producer alleles of the pro-inflammatory cytokines IL-1B, IL-6, IL-8, IL-10, and TNF-α who also carry low-producer allele of anti-inflammatory cytokines have severe gastric mucosal inflammation, whereas carriers of the alternative alleles have mild inflammation. Recent reports have suggested that the PSCA and CYP2C19 ultra-rapid metabolizer genotypes are also associated with PUD.
authors.affiliation: a 1 Oita University, Airlangga University, Surabaya, Indonesia.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Miftahussurur
authors.affiliation: b 2 Oita University, Baylor College of Medicine, Houston, USA.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaoka
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics; D000942:Antigens, Bacterial / Q000235:genetics; D000951:Antigens, Neoplasm / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics; D058851:GPI-Linked Proteins / Q000235:genetics; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity*; D007378:Interleukins / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D010437:Peptic Ulcer / Q000235:genetics* / Q000382:microbiology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D014774:Virulence / Q000235:genetics*; D037521:Virulence Factors / Q000235:genetics
chemical_list: D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; D000951:Antigens, Neoplasm; C400429:BabA protein, Helicobacter pylori; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C528428:DupA protein, Helicobacter pylori; D058851:GPI-Linked Proteins; D007378:Interleukins; D009363:Neoplasm Proteins; C526444:OipA protein, Helicobacter pylori; C110843:PSCA protein, human; D014409:Tumor Necrosis Factor-alpha; C074689:VacA protein, Helicobacter pylori; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori; C063113:ice nucleation protein; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19
keywords: CYP2C19; Helicobacter pylori; host genetic polymorphism; peptic ulcer disease; prostate stem cell antigen; virulence factors