title: Clinicopathological significance of Notch1 expression in cervical cancer patients: a meta-analysis.
abstract: OBJECTIVE
  Notch1 expression remains incompatible and contradictory with previous findings on cervical cancer. The purpose of this study is to evaluate the association between Notch1 and cervical cancer.
  
  
  METHODS
  Available studies were searched from diverse databases and Review Managers 5.3 software was used to perform analysis.
  
  
  RESULTS
  A total of 798 samples were included in this meta-analysis. The Notch1 expression in cancer tissues was higher than that in precancer (p = 0.0003) and normal tissues (p < 0.02). However, the difference of Notch1 expression between cancer cases and precancer cases has no statistical significance (p = 0.35). Moreover, lymph node metastasis (p = 0.02) was associated with higher Notch1 expression in cervical cancer.
  
  
  CONCLUSIONS
  Notch1 over-expression indicated aggressive biological behaviors.
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & The Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Lingxie
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & The Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Meng
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & The Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Peng
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & The Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & The Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Qi
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & The Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Wanyu
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & The Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.|Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & The Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.|Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology; D051881:Receptor, Notch1 / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D051881:Receptor, Notch1
keywords: Notch1; cervical cancer; clinicopathological parameters; expression; meta-analysis