title: Phenolics from strawberry cv. Falandi and their antioxidant and α-glucosidase inhibitory activities.
abstract: Three new phenolic glucosides, falandiosides A (1), B (2), and C (6) were isolated from strawberry (Fragaria×ananassa Duch.) cv. Falandi fruit, together with three flavone glucuronides (3-5), eleven lignan glycosides (12-22), and five others. Their structures were determined by spectroscopic methods. All the known phenolics were reported from strawberry for the first time. They were evaluated for antioxidant and α-glucosidase inhibitory activities. Three new and fifteen known phenolics showed potent 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical cation scavenging activity with IC50 values of 22.50-4.28μM in comparison to l-ascorbic acid (14.21μM). Quercetin 3-(6-methylglucuronide) (4), (+)-isolariciresinol 9'-glucoside (12), and (-)-isolariciresinol 9'-glucoside (13) were active in scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Moreover, compounds 12 and 13 had moderate ferric reducing antioxidant power (FRAP) values. Further, two new and seven known phenolics exhibited more potent α-glucosidase inhibitory activity with IC50 values of 537.43-25.39μM than acarbose (619.94μM).
authors.affiliation: Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China; University of Chinese Academy of Sciences, 19A Yuquanlu, Beijing 100049, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China. Electronic address: xiehaih@scbg.ac.cn.
authors.forename: Haihui
authors.initials: H
authors.lastname: Xie
authors.affiliation: Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China.
authors.forename: Yueming
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D031985:Fragaria / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D005960:Glucosides / Q000032:analysis / Q000737:chemistry*; D010636:Phenols / Q000032:analysis / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D000520:alpha-Glucosidases / Q000032:analysis
chemical_list: D000975:Antioxidants; D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; D000520:alpha-Glucosidases
keywords: (+)-Isolariciresinol 9′-glucoside (PubChem CID: 180275); Antioxidant activity; Aviculin (PubChem CID: 10391477); Cedrusin (PubChem CID: 384679); Phenolic compounds; Strawberry; Structure determination; Trichocarpin (PubChem CID: 442989); α-Glucosidase inhibitory activity