title: Fleeting Amyloid-like Forms of Rim4 Ensure Meiotic Fidelity.
abstract: Berchowitz et al. establish that transient amyloid-like forms of Rim4, a yeast RNA-binding protein with a predicted prion domain, translationally repress cyclin CLB3 in meiosis I, thereby ensuring homologous chromosome segregation. These findings suggest that prion domains might enable formation of tightly regulated amyloid-like effectors in diverse functional settings.
authors.affiliation: Department of Biochemistry and Biophysics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA; Neuroscience Graduate Group, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Alice Flynn
authors.initials: AF
authors.lastname: Ford
authors.affiliation: Department of Biochemistry and Biophysics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA; Neuroscience Graduate Group, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: jshorter@mail.med.upenn.edu.
authors.forename: James
authors.initials: J
authors.lastname: Shorter
mesh_terms: D000818:Animals; D005718:Gametogenesis; D008297:Male; D066329:Protein Aggregates; D016601:RNA-Binding Proteins / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: D066329:Protein Aggregates; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins