title: Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype.
abstract: Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system. In the present study we investigated how the 5-HTT genotype i.e. the short (S) versus long (L) 5-HTTLPR allele and the SNP rs25531 A > G affect the physical and psychosocial functioning in patients with chronic fatigue syndrome (CFS). All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years). Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI). Patients with the 5-HTT SS or SLG genotype had a significantly lower number of steps per day than patients with the 5-HTT LALG, SLA or LALA genotype. Patients with the 5-HTT SS or SLG genotype also had a significantly higher FDI score than patients with the 5-HTT LALG, SLA or LALA genotype. Thus, CFS patients with the 5-HTT SS or SLG genotype had worse 30 weeks outcome than CFS patients with the 5-HTT LALG, SLA or LALA genotype. The present study suggests that the 5-HTT genotype may be a factor that contributes to maintenance of CFS.
authors.affiliation: Dept. of Paediatrics, Akershus University Hospital, Oslo, Norway.
authors.forename: Benedicte
authors.initials: B
authors.lastname: Meyer
authors.affiliation: Dept. of Paediatrics, Akershus University Hospital, Oslo, Norway.
authors.forename: Chinh Bkrong Thuy
authors.initials: CB
authors.lastname: Nguyen
authors.affiliation: Dept. of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway; National Institute of Occupational Health, Oslo, Norway; Department of Biosciences, University of Oslo, Oslo, Norway.
authors.forename: Aurora
authors.initials: A
authors.lastname: Moen
authors.affiliation: Dept. of Anaesthesiology and Critical Care, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.
authors.forename: Even
authors.initials: E
authors.lastname: Fagermoen
authors.affiliation: Dept. of Paediatrics, Lillehammer County Hospital, Lillehammer, Norway; Dept. of Paediatrics, Oslo University Hospital, Oslo, Norway.
authors.forename: Dag
authors.initials: D
authors.lastname: Sulheim
authors.affiliation: Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway; Section for Clinical Molecular Biology, Akershus University Hospital, Oslo, Norway.
authors.forename: Hilde
authors.initials: H
authors.lastname: Nilsen
authors.affiliation: Dept. of Paediatrics, Akershus University Hospital, Oslo, Norway; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.
authors.forename: Vegard Bruun
authors.initials: VB
authors.lastname: Wyller
authors.affiliation: Dept. of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway; National Institute of Occupational Health, Oslo, Norway; Department of Biosciences, University of Oslo, Oslo, Norway.
authors.forename: Johannes
authors.initials: J
authors.lastname: Gjerstad
mesh_terms: D061725:Accelerometry; D000293:Adolescent; D002648:Child; D004311:Double-Blind Method; D015673:Fatigue Syndrome, Chronic / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012701:Serotonin / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin