title: Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding.
abstract: During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting.
authors.affiliation: Department of Global Health, University of Washington, Seattle, WA, United States of America.
authors.forename: Susan
authors.initials: S
authors.lastname: Morrison
authors.affiliation: Department of Global Health, University of Washington, Seattle, WA, United States of America; Department of Medicine, University of Washington, Seattle, WA United States of America; Department of Epidemiology, University of Washington, Seattle, United States of America.
authors.forename: Grace
authors.initials: G
authors.lastname: John-Stewart
authors.affiliation: The AIDS Support Organization, Kampala, Uganda.
authors.forename: John J
authors.initials: JJ
authors.lastname: Egessa
authors.affiliation: Infectious Disease Institute, Makerere University, Kampala, Uganda.
authors.forename: Sezi
authors.initials: S
authors.lastname: Mubezi
authors.affiliation: The AIDS Support Organization, Kampala, Uganda.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Kusemererwa
authors.affiliation: Center for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
authors.forename: Dennis K
authors.initials: DK
authors.lastname: Bii
authors.affiliation: Infectious Disease Institute, Makerere University, Kampala, Uganda.
authors.forename: Nulu
authors.initials: N
authors.lastname: Bulya
authors.affiliation: Kabwohe Clinical Research Center, Kabwohe, Uganda.
authors.forename: Francis
authors.initials: F
authors.lastname: Mugume
authors.affiliation: Centers for Disease Control and Prevention, Entebbe, Uganda.
authors.forename: James D
authors.initials: JD
authors.lastname: Campbell
authors.affiliation: The AIDS Support Organization, Kampala, Uganda.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Wangisi
authors.affiliation: Department of Global Health, University of Washington, Seattle, WA, United States of America; Center for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Bukusi
authors.affiliation: Department of Global Health, University of Washington, Seattle, WA, United States of America; Department of Medicine, University of Washington, Seattle, WA United States of America; Department of Epidemiology, University of Washington, Seattle, United States of America.
authors.forename: Connie
authors.initials: C
authors.lastname: Celum
authors.affiliation: Department of Global Health, University of Washington, Seattle, WA, United States of America; Department of Medicine, University of Washington, Seattle, WA United States of America; Department of Epidemiology, University of Washington, Seattle, United States of America.
authors.forename: Jared M
authors.initials: JM
authors.lastname: Baeten
mesh_terms: D000328:Adult; D000351:Africa, Eastern; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D001942:Breast Feeding / Q000009:adverse effects; D061345:Early Medical Intervention; D000068679:Emtricitabine / Q000008:administration & dosage; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D056990:Post-Exposure Prophylaxis / Q000379:methods; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D000068698:Tenofovir / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D000068698:Tenofovir; D000068679:Emtricitabine