title: Leptin concentration in children with juvenile idiopathic arthritis.
abstract: BACKGROUND
  Leptin regulates the organism's immune response. Juvenile idiopathic arthritis (JIA) is a chronic joint disease in children, leading to chronic changes in motor organs.
  
  
  METHODS
  In children with JIA (n = 42) and healthy subjects (n = 28), leptin concentration (LEP), body mass index (BMI), haematocrit (HTC), haemoglobin (HB), morphotic elements (WBC,LYMPH), erythrocyte sedimentation rate (ESR), and ANA Hep-2 antibodies were analysed. JIA group was divided into: children with a longer (51-148 months) (IA) n = 22 and a shorter disease period (2-18 months) (IB) n = 20.
  
  
  RESULTS
  Only 58.3% of the IA and 50% of the IB group had ANA Hep-2 confirmed. The ill children had higher and more diversified LYMPH and ESR levels compared to the healthy children. The highest LEP for the IA group was 37.5 ng/cm3, (Me 5.85), for IB - 40.10 ng/cm3, (Me 2.46) as compared to the IC - 3.74 ng/cm3 (Me 2.85), respectively. The average BMI value for the IA group was 16.61 kg/m2, for IC it was 18.91 kg/m2, and the median for IB was 15.89 kg/m2. Children with BMI values < 23 kg/m2 from the IA and IB group had a reduction in LEP as compared to control group (p = 0.04). The relationship between the illness and LEP diversification per BMI unit was found in both groups. Children with a shorter illness period had higher LEP differentiation per BMI unit compared to the healthy children.
  
  
  CONCLUSIONS
  Children with juvenile idiopathic arthritis with BMI < 23 kg/m2 had lower leptin concentrations than healthy subjects. Ill children with a shorter-term disease had a higher diversification of leptin concentration per BMI unit as compared to healthy controls.
authors.forename: Izabela
authors.initials: I
authors.lastname: Maciejewska-Paszek
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Grochowska-Niedworok
authors.forename: Andrzej
authors.initials: A
authors.lastname: Siwiec
authors.forename: Lechosław
authors.initials: L
authors.lastname: Dul
authors.forename: Anna
authors.initials: A
authors.lastname: Gruenpeter
authors.forename: Henryk
authors.initials: H
authors.lastname: Szczerba
authors.affiliation: Department of Health Promotion and Community Nursing, Medical University of Silesia, Katowice, Poland; Department of Nephrology/ENDO MSW Hospital Katowice, Poland. tirzyniec@sum.edu.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Irzyniec
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000097:blood*; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male
chemical_list: D020738:Leptin
keywords: BMI; juvenile idiopathic arthritis; leptin