title: Association of Plasma Myeloperoxidase Level with Risk of Coronary Artery Disease in Patients with Type 2 Diabetes.
abstract: OBJECTIVE
  This study aimed to investigate whether the change of plasma myeloperoxidase (MPO) level would be associated with the incidence of coronary artery disease (CAD) among diabetic patients.
  
  
  METHODS
  339 patients with type 2 diabetes mellitus (DM) underwent coronary angiography. Of them, 204 cases had CAD and were assigned to CAD group and 135 cases without CAD were assigned to non-CAD group.
  
  
  RESULTS
  Compared to non-CAD group, CAD group had higher level of plasma MPO (p < 0.01). Multiple linear regression analysis showed that plasma MPO level was correlated with Gensini score. Multiple logistic analysis showed that the odds ratios for CAD across increasing tertiles of MPO level were 1.191 (0.971-1.547) and 1.488 (1.115-2.228) (p = 0.048, p = 0.009 versus 1st tertile of MPO level, resp.) by adjusting for age, sex, and other conventional risk factors for CAD. The subjects were stratified into nine groups according to tertiles of MPO and HbA1c. The odds ratio for CAD was significantly higher in group with highest levels of MPO and HbA1c (OR = 4.08, p < 0.01).
  
  
  CONCLUSIONS
  Plasma MPO level was positively correlated with the degree of coronary artery stenosis in type 2 diabetic patients, and increasing blood glucose might amplify the association between MPO and CAD.
authors.affiliation: Department of Endocrinology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Jinan, Shandong 250021, China ; Shandong Clinical Medical Center of Endocrinology and Metabolism, No. 324, Jing 5 Road, Jinan, Shandong 250021, China ; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, No. 324, Jing 5 Road, Jinan, Shandong 250021, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Song
authors.affiliation: Department of Endocrinology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Jinan, Shandong 250021, China ; Shandong Clinical Medical Center of Endocrinology and Metabolism, No. 324, Jing 5 Road, Jinan, Shandong 250021, China ; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, No. 324, Jing 5 Road, Jinan, Shandong 250021, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Jinan, Shandong 250021, China ; Shandong Clinical Medical Center of Endocrinology and Metabolism, No. 324, Jing 5 Road, Jinan, Shandong 250021, China ; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, No. 324, Jing 5 Road, Jinan, Shandong 250021, China.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Jinan, Shandong 250021, China.
authors.forename: Shiliang
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Jinan, Shandong 250021, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Endocrinology, Shandong Provincial Hospital, Shandong University, No. 324, Jing 5 Road, Jinan, Shandong 250021, China ; Shandong Clinical Medical Center of Endocrinology and Metabolism, No. 324, Jing 5 Road, Jinan, Shandong 250021, China ; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, No. 324, Jing 5 Road, Jinan, Shandong 250021, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; D009195:Peroxidase; C517652:hemoglobin A1c protein, human