title: In Vivo pO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance.
abstract: For over a century, it has been known that tumor hypoxia, regions of a tumor with low levels of oxygenation, are important contributors to tumor resistance to radiation therapy and failure of radiation treatment of cancer. Recently, using novel pulse electron paramagnetic resonance (EPR) oxygen imaging, near absolute images of the partial pressure of oxygen (pO2) in tumors of living animals have been obtained. We discuss here the means by which EPR signals can be obtained in living tissues and tumors. We review development of EPR methods to image the pO2 in tumors and the potential for the pO2 image acquisition in human subjects.
authors.affiliation: Center for Electron Paramagnetic Resonance Imaging In Vivo Physiology, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, USA.
authors.forename: Boris
authors.initials: B
authors.lastname: Epel
authors.affiliation: Center for Electron Paramagnetic Resonance Imaging In Vivo Physiology, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, USA. Electronic address: h-halpern@uchicago.edu.
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Halpern
mesh_terms: D000818:Animals; D004578:Electron Spin Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D009369:Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D010092:Oximetry / Q000295:instrumentation / Q000379:methods*; D010100:Oxygen / Q000032:analysis* / Q000378:metabolism
chemical_list: D010100:Oxygen
keywords: Elecctron paramagnetic resonance imaging; Image registration; Molecular O(2) imaging; Quantitative physiologic imaging