title: The right place at the right time: chaperoning core histone variants.
abstract: Histone proteins dynamically regulate chromatin structure and epigenetic signaling to maintain cell homeostasis. These processes require controlled spatial and temporal deposition and eviction of histones by their dedicated chaperones. With the evolution of histone variants, a network of functionally specific histone chaperones has emerged. Molecular details of the determinants of chaperone specificity for different histone variants are only slowly being resolved. A complete understanding of these processes is essential to shed light on the genuine biological roles of histone variants, their chaperones, and their impact on chromatin dynamics.
authors.affiliation: Department of Molecular and Radiobiological Sciences, Howard Hughes Medical Institute, Colorado State University, Fort Collins, CO, USA francesca.mattiroli@colorado.edu.
authors.forename: Francesca
authors.initials: F
authors.lastname: Mattiroli
authors.affiliation: Department of Molecular and Radiobiological Sciences, Howard Hughes Medical Institute, Colorado State University, Fort Collins, CO, USA.
authors.forename: Sheena
authors.initials: S
authors.lastname: D'Arcy
authors.affiliation: Department of Molecular and Radiobiological Sciences, Howard Hughes Medical Institute, Colorado State University, Fort Collins, CO, USA.
authors.forename: Karolin
authors.initials: K
authors.lastname: Luger
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry; D056488:Histone Chaperones / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis; D008958:Models, Molecular; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics / Q000502:physiology
chemical_list: D002843:Chromatin; D056488:Histone Chaperones; D006657:Histones; D009707:Nucleosomes
keywords: chromatin dynamics; histone chaperones; histone variants; nucleosome