title: Compact chelator-free Ni-integrated CuS nanoparticles with tunable near-infrared absorption and enhanced relaxivity for in vivo dual-modal photoacoustic/MR imaging.
abstract: A chelator-free doping method is developed for constructing a Ni-integrated CuS nanostructure as a novel PA/MRI contrast agent. It exhibits tunable near-infrared absorption. Moreover, the hybrid nanostructure has demonstrated a dramatically enhanced T1 relaxivity compared with Ni ions. Due to these unique properties, chelator-free nanoparticles have been successfully applied for in vivo PA/MRI dual-modal imaging.
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory for Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Duyang
authors.initials: D
authors.lastname: Gao
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhang
authors.forename: Chengbo
authors.initials: C
authors.lastname: Liu
authors.forename: Chi
authors.initials: C
authors.lastname: Chen
authors.forename: Guanhui
authors.initials: G
authors.lastname: Gao
authors.forename: Yayun
authors.initials: Y
authors.lastname: Wu
authors.forename: Zonghai
authors.initials: Z
authors.lastname: Sheng
authors.forename: Liang
authors.initials: L
authors.lastname: Song
authors.forename: Lintao
authors.initials: L
authors.lastname: Cai
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D009532:Nickel / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011859:Radiography; D013053:Spectrophotometry
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D011092:Polyethylene Glycols; D003300:Copper; D009532:Nickel; C017846:cupric sulfide