title: Collision of lymphoepithelioma-like carcinoma and adenocarcinoma of the lung: a case report.
abstract: We report a rare case of collision of lymphoepithelioma-like carcinoma (LELC) and adenocarcinoma (AC) in the lung. A 59-year-old woman had a history of fever and cough. A mass was found by X-ray in the left upper lung. Magnetic resonance imaging (MRI) shows a dumbbell-like mass in the fore and tongue segment of the left upper lung with irregular spiculate margin. Positron emission tomography/computed tomography (PET/CT) (18F-FDG) shows strong concentration of radioactivity (SUVmax 6.9-12.3 cm) in the lung mass only. The patient subsequently underwent resection of left upper lung and associated hilar lymph nodes. Histological examination revealed it was a collision carcinoma comprising LELC and AC. The hilar lymph nodes were tumuor free. The immunoreactions, Epstein-Barr early RNA in situ hybridization and molecular analyses, such as EGFR mutation, c-Met, anaplastic lymphoma kinase were different in both tumuor components, indicating they derived from different cell origin. This rare case was discussed.
authors.affiliation: Department of Pathology, Kiang Wu Hospital, Macau Special Administrative Region, China.
authors.forename: Jammy Kin Iong
authors.initials: JKI
authors.lastname: Chan
authors.affiliation: Department of Pathology, Kiang Wu Hospital, Macau Special Administrative Region, China.
authors.forename: Wai Meng
authors.initials: WM
authors.lastname: Tai
authors.affiliation: Department of Pathology, Kiang Wu Hospital, Macau Special Administrative Region, China.
authors.forename: Jian Ming
authors.initials: JM
authors.lastname: Wen
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D014408:Biomarkers, Tumor; D020031:Epstein-Barr Virus Infections; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D019788:Fluorodeoxyglucose F18
keywords: adenocarcinoma - collision carcinoma - lung - lymphoepithelioma-like carcinoma