title: [Association between neontal morbidity, gestational age and developmental delays in moderate to late preterm children].
abstract: BACKGROUND
  There is evidence that children born moderate-to-late preterm (MLP) have a higher risk of hospitalisation, neonatal morbidity, and developmental delay (DD).
  
  
  OBJECTIVE
  To determine the association between DD, gestational age, and neonatal morbidity in MLP children.
  
  
  METHODS
  A case control study design nested in a cohort of MLP children born between 2006 and 2009 at a private hospital located in the Metropolitan area of Santiago. The children were assessed with the Bayley-III Scales of Infant Development at 8 or 18 months corrected age, or at 30 months of chronological age. Neonatal records were retrospectively reviewed. A multivariate analysis was performed to determine the effect of neonatal morbidity on development.
  
  
  RESULTS
  A total of 130 MLP children, 25 cases and 105 controls, were studied. Most of them (83.8%) were hospitalised during the neonatal period. Significant differences between cases and controls regarding maternal age and symptomatic hypoglycaemia were observed (crude OR 3.5, adjusted OR 8.18). It was concluded that the variables that negatively affect the rate of development are male gender, being a twin, and gestational age.
  
  
  CONCLUSIONS
  Symptomatic hypoglycaemia is the main risk factor for DD, while being a twin, male gender, and gestational age influenced the total development rate obtained. It is essential to develop strategies for prevention, screening, and early management of this metabolic disorder to prevent future DD.
authors.affiliation: Servicio de Pediatría, Clínica Alemana, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile. Electronic address: lschonhaut@alemana.cl.
authors.forename: Luisa
authors.initials: L
authors.lastname: Schonhaut
authors.affiliation: Servicio de Pediatría, Clínica Alemana, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile.
authors.forename: Marcela
authors.initials: M
authors.lastname: Pérez
authors.affiliation: Centro de Investigación y Gestión para la Evidencia en Salud (CIGES), Universidad de La Frontera, Temuco, Chile.
authors.forename: Sergio
authors.initials: S
authors.lastname: Muñoz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D002677:Chile; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005865:Gestational Age; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007003:Hypoglycemia / Q000150:complications; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Desarrollo psicomotor; Edad gestación; Gestational age; Hipoglucemia; Hypoglycaemia; Late preterm; Moderate preterm; Morbilidad neonatal; Neonatal morbidity; Prematuro moderado; Prematuro tardío; Psychomotor development