title: Benefits of L-Arginine on Cardiovascular System.
abstract: The amino acid, L-Arginine (L-Arg) plays an important role in the cardiovascular system. Data from the literature show that L-Arg is the only substrate for the production of nitric oxide (NO), from which L-Arg develops its effects on the cardiovascular system. As a free radical, NO is synthesized in all mammalian cells by L-Arg with the activity of NO synthase (NOS). In states of hypertension, diabetes, hypercholesterolemia and vascular inflammation a disorder occurs in the metabolic pathway of the synthesis of NO from L-Arg which all together bring alterations of blood vessels. Experimental results obtained on animals, as well as clinical studies show that L-Arg has an effect on thrombocytes, on the process of coagulation and on the fibrolytic system. This mini review represents a summary of the latest scientific animal and human studies related to L-Arg and its mechanisms of actions with a focus on the role of L-Arg via NO pathway in cardiovascular disorders. Moreover, here we present data from recent animal and clinical studies suggesting that L-Arg could be one of the possible therapeutic molecules for improving the treatment of different cardiovascular disorders.
authors.forename: Emina
authors.initials: E
authors.lastname: Sudar-Milovanovic
authors.forename: Milan
authors.initials: M
authors.lastname: Obradovic
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Jovanovic
authors.forename: Bozidarka
authors.initials: B
authors.lastname: Zaric
authors.forename: Sonja
authors.initials: S
authors.lastname: Zafirovic
authors.forename: Anastasija
authors.initials: A
authors.lastname: Panic
authors.forename: Djordje
authors.initials: D
authors.lastname: Radak
authors.affiliation: Institute of Nuclear Sciences Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, P.O. Box 522, 11000 Belgrade, Serbia. isenovic@yahoo.com.
authors.forename: Esma R
authors.initials: ER
authors.lastname: Isenovic
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis
chemical_list: D009569:Nitric Oxide; D001120:Arginine