title: Swelling and drug release behavior of metformin HCl-loaded tamarind seed polysaccharide-alginate beads.
abstract: The paper describes the preparation, characterization, in vitro swelling and in vitro drug release of metformin HCl-loaded tamarind seed polysaccharide (TSP)-alginate beads were prepared by ionotropic-gelation technique and using CaCl2 as cross-linker. The prepared beads exhibited 32.73 ± 1.41% of drug loading (%), 94.86 ± 3.92% of drug encapsulation efficiency (%), and 1.24 ± 0.07 mm of average bead size. The bead surface morphology was analyzed by SEM. The drug-polymer interaction in the bead matrix was analyzed by FTIR analyses. These metformin HCl-loaded ionotropically gelled TSP-alginate beads demonstrated sustained in vitro drug release profile over 10h. These in vitro drug release exhibited pH-dependent drug release behavior. The in vitro drug release from these metformin HCl-loaded beads followed controlled-release (zero-order) pattern with super case-II transport mechanism. The swelling and degradation of these metformin HCl-loaded polymeric beads were found to be influenced by the pH of test mediums.
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India. Electronic address: amitkrnayak@yahoo.co.in.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.affiliation: Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur 495009, C.G., India.
authors.forename: Dilipkumar
authors.initials: D
authors.lastname: Pal
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India.
authors.forename: Kousik
authors.initials: K
authors.lastname: Santra
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry; D008687:Metformin / Q000008:administration & dosage* / Q000737:chemistry; D008863:Microspheres; D010936:Plant Extracts / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry* / Q000648:ultrastructure; D012639:Seeds / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides; D020723:Glucuronic Acid; D008687:Metformin
keywords: Ionotropic-gelation; Sodium alginate; Tamarind seed polysaccharide