title: PKCs in thrombus formation.
abstract: The protein kinase C (PKC) family has been implicated in several physiological processes regulating platelet activation. Each isoform of PKC expressed on platelets, may have a positive and/or negative role depending on the nature and concentration of the agonist. Mice lacking PKCα show much reduced thrombus formation in vivo, while PKCθ(-/-) showed inhibition of aggregation in response to PAR4. On the other hand, PKCδ by associating with Fyn, inhibits platelet aggregation. In addition, PKCβ by interacting with its receptor RACK1 has been implicated in the primary phases of signaling via the αIIbβ3 and finally PKCɛ appears to be involved in platelet function downstream GPVI. The present review discusses the latest observations relevant to the role of individual PKC isoforms in platelet activation and thrombus formation.
authors.affiliation: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, H1T 1C8 Quebec, Canada. Electronic address: younes_zaid@yahoo.ca.
authors.forename: Y
authors.initials: Y
authors.lastname: Zaid
authors.affiliation: Laboratory of Genetic and Molecular Pathology (LGPM), Medical School, Hassan II University, Casablanca, Morocco.
authors.forename: N
authors.initials: N
authors.lastname: Senhaji
authors.affiliation: Laboratory of Physiology and Molecular Genetic, Faculty of Sciences, Hassan II University, Casablanca, Morocco.
authors.forename: A
authors.initials: A
authors.lastname: Naya
authors.affiliation: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, H1T 1C8 Quebec, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Fadainia
authors.affiliation: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, H1T 1C8 Quebec, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Kojok
mesh_terms: D000818:Animals; D006801:Humans; D007527:Isoenzymes; D051379:Mice; D018345:Mice, Knockout; D015539:Platelet Activation / Q000235:genetics; D010974:Platelet Aggregation / Q000235:genetics; D011493:Protein Kinase C / Q000235:genetics / Q000502:physiology*; D013927:Thrombosis / Q000235:genetics*
chemical_list: D007527:Isoenzymes; D011493:Protein Kinase C
keywords: Aggregation; Agrégation; PKC; Plaquette; Platelet; Thrombus