title: Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia.
abstract: The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-27) and IL-35. EBI3 has been reported to associate with HLA-G. In this small pilot study we find higher decidual EBI3 (p<0.05) and HLA-G (p<0.01) mRNA expression in preeclampsia (n=7) compared to normotensive (n=8) pregnancies. Whether the higher EBI3 and HLA-G mRNA expression is a consequence or cause of preeclampsia remains to be answered. Further research to determine the effects on IL-27 and IL-35 is needed.
authors.affiliation: Department of Obstetrics, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands. Electronic address: j.r.prins@umcg.nl.
authors.forename: J R
authors.initials: JR
authors.lastname: Prins
authors.affiliation: Department of Obstetrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: M L P
authors.initials: MLP
authors.lastname: van der Hoorn
authors.affiliation: Laboratory Reproductive Biology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Keijser
authors.affiliation: Laboratory Reproductive Biology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Department of Obstetrics and Gynaecology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Ris-Stalpers
authors.affiliation: Department of Obstetrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: van Beelen
authors.affiliation: Laboratory Reproductive Biology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: G B
authors.initials: GB
authors.lastname: Afink
authors.affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: F H J
authors.initials: FHJ
authors.lastname: Claas
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: J A M
authors.initials: JAM
authors.lastname: van der Post
authors.affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: S A
authors.initials: SA
authors.lastname: Scherjon
mesh_terms: D000328:Adult; D003656:Decidua / Q000378:metabolism*; D005260:Female; D059951:HLA-G Antigens / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D064094:Interleukin-27 / Q000235:genetics; D007378:Interleukins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens; D010865:Pilot Projects; D011225:Pre-Eclampsia / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy; D023001:Transplantation Tolerance; D015854:Up-Regulation; D055815:Young Adult
chemical_list: C097732:EBI3 protein, human; D059951:HLA-G Antigens; D064094:Interleukin-27; D007378:Interleukins; D015778:Minor Histocompatibility Antigens; C532417:interleukin-35, human
keywords: EBI3; HLA-G; Immunology; Preeclampsia; Pregnancy