title: Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats.
abstract: Albiflorin (AF), separated from the root of Paeonia lactiflora Pall, possesses neuro-protective and anti-inflammatory activities. Based on previous results, our present research aims to investigate the antidepressant-like activity of AF in chronic unpredictable mild stress (CUMS)-induced rat model of depression. Eight weeks of CUMS process successfully established depression-like rat model, as evidenced by the enhanced immobility time in forced swimming test and the reduced sucrose preference, which were reversed to near normal by AF (20 mg/kg and 40 mg/kg) and fluoxetine (3 mg/kg; positive drug) treated. Compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HTAA) in serum and hypothalamus, and the reduced expressions of 5-HT1A receptor and 5-HT2A receptor in hypothalamus were observed after AF and fluoxetine oral administration indicating that AF-mediated antidepressant-like effect may be related to the normalization of serotonergic system. Additionally, four-week AF treated rats significantly showed improvement in the reduced dopamine and noradrenalin concentration in serum and hypothalamus as observed on depression-like rats. Altered levels of tyrosine hydroxylase, dopamine D2 receptor and dopamine transporter in hypothalamus reverted to the normal level after treatment with both AF and fluoxetine. All these data demonstrate that not only serotonergic system, but also dopaminergic system is involved in AF-mediated antidepressant-like effect in CUMS-induced rat model of depression.
authors.affiliation: School of Life Sciences, Jilin University, Changchun, 130012, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Song
authors.affiliation: School of Life Sciences, Jilin University, Changchun, 130012, China.
authors.forename: Xintong
authors.initials: X
authors.lastname: Hou
authors.affiliation: Faculty of Medicine, Changchun Medical College, Changchun, 130013, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Hu
authors.affiliation: School of Life Sciences, Jilin University, Changchun, 130012, China.
authors.forename: Chengyu
authors.initials: C
authors.lastname: Lu
authors.affiliation: School of Life Sciences, Jilin University, Changchun, 130012, China.
authors.forename: Chungang
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Jilin University, Changchun, 130012, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Faculty of Medicine, Changchun Medical College, Changchun, 130013, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Jilin University, Changchun, 130012, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Teng
authors.affiliation: School of Life Sciences, Jilin University, Changchun, 130012, China; Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, 130118, China. Electronic address: jluwangdi@outlook.com.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D001952:Bridged-Ring Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000523:psychology*; D004298:Dopamine / Q000097:blood / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000097:blood / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000097:blood / Q000378:metabolism*; D013315:Stress, Psychological / Q000150:complications*; D006027:Glycosides
chemical_list: D000928:Antidepressive Agents; D001952:Bridged-Ring Compounds; D004298:Dopamine; D006897:Hydroxyindoleacetic Acid; D009638:Norepinephrine; D012701:Serotonin; C014959:albiflorin; D006027:Glycosides
keywords: Albiflorin; Depression; Dopaminergic system; Serotonergic system