title: Effects of addictive drugs on adult neural stem/progenitor cells.
abstract: Neural stem/progenitor cells (NSPCs) undergo a series of developmental processes before giving rise to newborn neurons, astrocytes and oligodendrocytes in adult neurogenesis. During the past decade, the role of NSPCs has been highlighted by studies on adult neurogenesis modulated by addictive drugs. It has been proven that these drugs regulate the proliferation, differentiation and survival of adult NSPCs in different manners, which results in the varying consequences of adult neurogenesis. The effects of addictive drugs on NSPCs are exerted via a variety of different mechanisms and pathways, which interact with one another and contribute to the complexity of NSPC regulation. Here, we review the effects of different addictive drugs on NSPCs, and the related experimental methods and paradigms. We also discuss the current understanding of major signaling molecules, especially the putative common mechanisms, underlying such effects. Finally, we review the future directions of research in this area.
authors.affiliation: Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church St. SE, Minneapolis, MN, 55455, USA. xchi@umn.edu.
authors.forename: Chi
authors.identifier: http://orcid.org/0000-0001-5470-7376
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church St. SE, Minneapolis, MN, 55455, USA.
authors.forename: Horace H
authors.initials: HH
authors.lastname: Loh
authors.affiliation: Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church St. SE, Minneapolis, MN, 55455, USA.
authors.forename: Ping-Yee
authors.initials: PY
authors.lastname: Law
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000661:Amphetamine / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D005731:Ganglionic Stimulants / Q000494:pharmacology; D006801:Humans; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology; D058953:Neural Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology; D019966:Substance-Related Disorders / Q000378:metabolism
chemical_list: D000701:Analgesics, Opioid; D002186:Cannabinoids; D000697:Central Nervous System Stimulants; D005731:Ganglionic Stimulants; D018377:Neurotransmitter Agents; D000431:Ethanol; D009538:Nicotine; D000661:Amphetamine; D003042:Cocaine; D018817:N-Methyl-3,4-methylenedioxyamphetamine
keywords: Addictive drugs; Adult neurogenesis; Differentiation; Neural stem/progenitor cells; Proliferation; Survival