title: Gold nanoparticle-enhanced target for MS analysis and imaging of harmful compounds in plant, animal tissue and on fingerprint.
abstract: Gold nanoparticle-enhanced target (AuNPET) was used for detailed investigation of various materials of biological origin - human fingerprint, onion bulb and chicken liver. Analysis of these objects was focused on toxic and harmful compounds - designer drug containing pentedrone, diphenylamine in onion and potentially cancerogenic metronidazole antibiotic in liver. Detection of large quantity of endogenous compounds from mentioned objects is also shown. Most of analyzed compounds were also localized with MS imaging and relationship between their function and location was discussed. Detected compounds belong to a very wide range of chemical compounds such as saccharides, ionic and non-ionic glycerides, amino acids, fatty acids, sulfides, sulfoxides, phenols etc. Fingerprint experiments demonstrate application of AuNPET for detection, structure confirmation and also co-localization of drug with ridge patterns proving person-drug contact.
authors.affiliation: Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Sekuła
authors.affiliation: Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Nizioł
authors.affiliation: Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Misiorek
authors.affiliation: Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Dec
authors.affiliation: Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wrona
authors.affiliation: Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland.
authors.forename: Adrian
authors.initials: A
authors.lastname: Arendowski
authors.affiliation: Rzeszów University of Technology, Faculty of Chemistry, Bioorganic Chemistry Laboratory, 6 Powstańców Warszawy Ave., 35-959 Rzeszów, Poland. Electronic address: tomruman@prz.edu.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Ruman
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis; D003878:Dermatoglyphics; D004159:Diphenylamine / Q000032:analysis; D006046:Gold / Q000737:chemistry*; D015386:Hazardous Substances / Q000032:analysis*; D006801:Humans; D008099:Liver / Q000737:chemistry*; D013058:Mass Spectrometry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008744:Methylamines / Q000032:analysis; D008795:Metronidazole / Q000032:analysis; D019697:Onions / Q000737:chemistry*; D010422:Pentanones / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D015386:Hazardous Substances; D008744:Methylamines; D010422:Pentanones; D008795:Metronidazole; C572410:pentedrone; D006046:Gold; D004159:Diphenylamine
keywords: Designer drug; Fingerprint; Gold nanoparticles; Imaging; Low molecular weight compounds; Mass spectrometry