title: Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey.
abstract: BACKGROUND
  Analysis of mutations in the epidermal growth factor receptor gene (EGFR) is important for predicting response to EGFR tyrosine kinase inhibitors. The overall rate of EGFR mutations in Korean patients is variable. To obtain comprehensive data on the status of EGFR mutations in Korean patients with lung cancer, the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists initiated a nationwide survey.
  
  
  METHODS
  We obtained 1,753 reports on EGFR mutations in patients with lung cancer from 15 hospitals between January and December 2009. We compared EGFR mutations with patient age, sex, history of smoking, histologic diagnosis, specimen type, procurement site, tumor cell dissection, and laboratory status.
  
  
  RESULTS
  The overall EGFR mutation rate was 34.3% in patients with non-small cell lung cancer (NSCLC) and 43.3% in patients with adenocarcinoma. EGFR mutation rate was significantly higher in women, never smokers, patients with adenocarcinoma, and patients who had undergone excisional biopsy. EGFR mutation rates did not differ with respect to patient age or procurement site among patients with NSCLC.
  
  
  CONCLUSIONS
  EGFR mutation rates and statuses were similar to those in published data from other East Asian countries.
authors.affiliation: Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Sang Hwa
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Wan Seop
authors.initials: WS
authors.lastname: Kim
authors.affiliation: Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Yoo Duk
authors.initials: YD
authors.lastname: Choi
authors.affiliation: Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jeong Wook
authors.initials: JW
authors.lastname: Seo
authors.affiliation: Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Joung Ho
authors.initials: JH
authors.lastname: Han
authors.affiliation: Yeungnam University College of Medicine, Daegu, Korea.
authors.forename: Mi Jin
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Inha University College of Medicine, Incheon, Korea.
authors.forename: Lucia
authors.initials: L
authors.lastname: Kim
authors.affiliation: National Cancer Center, Goyang, Korea.
authors.forename: Geon Kook
authors.initials: GK
authors.lastname: Lee
authors.affiliation: Busan National University School of Medicine, Busan, Korea.
authors.forename: Chang Hun
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Mee Hye
authors.initials: MH
authors.lastname: Oh
authors.affiliation: Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Gou Young
authors.initials: GY
authors.lastname: Kim
authors.affiliation: Ewha Womans University School of Medicine, Seoul, Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Sung
authors.affiliation: Seoul St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.
authors.forename: Kyo Young
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Inje University Ilsan Paik Hospital, Goyang, Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Chang
authors.affiliation: Dong-A University College of Medicine, Busan, Korea.
authors.forename: Mee Sook
authors.initials: MS
authors.lastname: Rho
authors.affiliation: Korea University College of Medicine, Seoul, Korea.
authors.forename: Han Kyeom
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Soon Hee
authors.initials: SH
authors.lastname: Jung
authors.affiliation: Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Jang
keywords: Lung neoplasms; Mutation survey; Receptor, epidermal growth factor