title: Clofarabine associated capillary leak syndrome in a child with lymphoma successfully treated with intravenous immunoglobulin.
abstract: Clofarabine is an effective drug in relapsed leukemia and lymphoma that has some adverse effects which can be fatal like capillary leak syndrome (CLS). Identification and management of CLS is important that may result in mortality. Although prophylactic treatment with steroids may prevent CLS and improve survival, intravenous immunoglobulins are used in the treatment with great success in steroid resistant cases. However, the knowledge about the effects and the dose of intravenous immunoglobulins (IVIG) in pediatric patients is limited. Herein, we reported a patient with relapsed lymphoma who developed CLS successfully and was treated with IVIG.
authors.forename: Vural
authors.initials: V
authors.lastname: Kesik
authors.affiliation: Department of Pediatric Oncology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey.
authors.forename: Erman
authors.initials: E
authors.lastname: Atas
authors.forename: Nadir
authors.initials: N
authors.lastname: Korkmazer
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Babacan
mesh_terms: D000227:Adenine Nucleotides / Q000009:adverse effects*; D001087:Arabinonucleosides / Q000009:adverse effects*; D019559:Capillary Leak Syndrome / Q000139:chemically induced; D002675:Child, Preschool; D000077866:Clofarabine; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008223:Lymphoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male
chemical_list: D000227:Adenine Nucleotides; D001087:Arabinonucleosides; D016756:Immunoglobulins, Intravenous; D000077866:Clofarabine