title: Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform.
abstract: Nanoparticles have demonstrated unique advantages in enhancing immunotherapy potency and have drawn increasing interest in developing safe and effective vaccine formulations. Recent technological advancement has led to the discovery and development of cell membrane-coated nanoparticles, which combine the rich functionalities of cellular membranes and the engineering flexibility of synthetic nanomaterials. This new class of biomimetic nanoparticles has inspired novel vaccine design strategies with strong potential for modulating antibacterial immunity. This article will review recent progress on using cell membrane-coated nanoparticles for antibacterial vaccination. Specifically, two major development strategies will be discussed, namely (i) vaccination against virulence factors through bacterial toxin sequestration; and (ii) vaccination against pathogens through mimicking bacterial antigen presentation.
authors.affiliation: Department of NanoEngineering and Moores Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA. pangsant@ucsd.edu.
authors.forename: Pavimol
authors.initials: P
authors.lastname: Angsantikul
authors.affiliation: Department of NanoEngineering and Moores Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA. sthamphi@ucsd.edu.
authors.forename: Soracha
authors.initials: S
authors.lastname: Thamphiwatana
authors.affiliation: Department of NanoEngineering and Moores Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA. w5gao@ucsd.edu.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of NanoEngineering and Moores Cancer Center, University of California, La Jolla, San Diego, CA 92093, USA. zhang@ucsd.edu.
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
keywords: biomimetic nanoparticle; infectious disease; membrane coating; nanomedicine; nanovaccine