title: Direct Alkylation of Amines with Alcohols Catalyzed by Base.
abstract: A base-catalyzed/promoted transition-metal-free direct alkylation of amines with alcohols has been developed, giving the desired amines in generally high yields from either aromatic or aliphatic alcohols. On the basis of the (1)H NMR and in situ IR (React-IR) monitoring experiments, isotope-labeling experiments, as well as control experiments, a novel "hemiaminal" model is proposed to understand the mechanism, which explains the formation of the "extra" aldehyde in the reaction.
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Qiang-Qiang
authors.initials: QQ
authors.lastname: Li
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Zu-Feng
authors.initials: ZF
authors.lastname: Xiao
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Chuan-Zhi
authors.initials: CZ
authors.lastname: Yao
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Hong-Xing
authors.initials: HX
authors.lastname: Zheng
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Yan-Biao
authors.initials: YB
authors.lastname: Kang