title: The relationships between bone mineral density and radiographic features of hand or knee osteoarthritis in older adults: data from the Dong-gu Study.
abstract: OBJECTIVE
  The relationship between OA and osteoporosis has exhibited contradictory features over the past four decades. The aim of this study was to determine using separate analysis of the radiographic features of OA whether various radiographic features of OA were associated differently with BMD in the Korean elderly.
  
  
  METHODS
  Data were derived from the Dong-gu cohort; 2354 subjects were enrolled in the present cross-sectional study. Baseline characteristics, the BMDs of the lumbar spine and femoral neck measured by DXA, and X-rays of knees and hands were collected. A semi-quantitative grading system was used to estimate the severities of individual radiographic features. We adjusted for confounders using multiple linear regression modelling to analyse the relationships.
  
  
  RESULTS
  After adjustment for confounders, hand and knee OA total scores were negatively associated with the BMDs of the lumbar spine and femoral neck, except for the total knee OA score and lumbar spine BMD. In detail, hand osteophytes and sclerosis exhibited positive relationships with the BMDs of the lumbar spine and femoral neck, except for hand osteophytes and femoral neck BMD. On the contrary, however, knee joint space narrowing (JSN), hand JSN, and hand subchondral cysts were negatively associated with the BMD of the lumbar spine and femoral neck. Knee JSN and hand subchondral cysts exerted the greatest effects on BMD.
  
  
  CONCLUSIONS
  Separate analysis of the radiographic features of OA better reveals associations of OA with the BMD of the lumbar spine and femoral neck.
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju, shinseok@chonnam.ac.kr.
authors.forename: Lihui
authors.initials: L
authors.lastname: Wen
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju.
authors.forename: Ji-Hyoun
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju.
authors.forename: Yi-Rang
authors.initials: YR
authors.lastname: Yim
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju.
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Kim
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju.
authors.forename: Jeong-Won
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju.
authors.forename: Kyung-Eun
authors.initials: KE
authors.lastname: Lee
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju.
authors.forename: Dong-Jin
authors.initials: DJ
authors.lastname: Park
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju.
authors.forename: Tae-Jong
authors.initials: TJ
authors.lastname: Kim
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju.
authors.forename: Yong-Wook
authors.initials: YW
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun.
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.affiliation: Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan and.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Gwangju-Jeonnam Regional Cardiocerebrovascular Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
authors.forename: Yong-Woon
authors.initials: YW
authors.lastname: Yun
authors.affiliation: Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju.
authors.forename: Shin-Seok
authors.initials: SS
authors.lastname: Lee
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000368:Aged; D015519:Bone Density / Q000502:physiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015577:Geriatric Assessment; D050823:Hand Joints / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging*; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D011379:Prognosis; D056910:Republic of Korea; D012720:Severity of Illness Index
keywords: bone mineral density; osteoarthritis; radiography