title: Delayed clearance of triglyceride-rich lipoproteins in young, healthy obese subjects.
abstract: Obesity is associated with the metabolic syndrome. The aims were, first, to study the postprandial triglyceride clearance in young, healthy obese subjects and, second, to investigate if fasting triglycerides can predict delayed postprandial triglyceride clearance. Eighteen apparently healthy, obese subjects with no clinical signs of metabolic disturbances participated. Controls were age- and sex-matched, healthy, normal weight subjects. Subclinical markers of metabolic disturbances were assessed by measuring postprandial triglycerides in serum and in chylomicrons by oral fat tolerance test. Postprandial triglyceride clearance for 8 h was assessed indirectly as removal of the lipid from serum during the oral fat tolerance test. Insulin resistance was measured by the homeostasis model assessment of insulin resistance (HOMA-IR). Twelve (66%) of the apparently healthy obese individuals had insulin resistance measured by HOMA-IR. There was a delayed clearance of serum triglycerides and chylomicron triglycerides at 6 h when compared with the control group, while, at 8 h, the differences were only detected for the chylomicron triglyceride clearance. Triglyceride response was significantly greater in the obese subjects. Fasting triglycerides in upper normal level predicted a delayed postprandial triglyceride clearance and insulin resistance. In young, apparently healthy obese subjects early metabolic disturbances including insulin resistance and delayed postprandial triglyceride clearance can be detected. Fasting serum triglyceride in upper normal level predicted delayed postprandial triglyceride clearance and insulin resistance.
authors.affiliation: Research Group of Gastroenterology and Nutrition, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.
authors.forename: M A
authors.identifier: http://orcid.org/0000-0001-9398-6996
authors.initials: MA
authors.lastname: Larsen
authors.affiliation: Research Group of Gastroenterology and Nutrition, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.|Department of Gastroenterology, Clinic of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Goll
authors.affiliation: Childrens Department, Morbid Obesity Center, Helse Sør-Øst, Tønsberg, Norway.
authors.forename: S
authors.initials: S
authors.lastname: Lekahl
authors.affiliation: Research Group of Gastroenterology and Nutrition, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.
authors.forename: O S
authors.initials: OS
authors.lastname: Moen
authors.affiliation: Research Group of Gastroenterology and Nutrition, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.|Department of Gastroenterology, Clinic of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
authors.forename: J
authors.initials: J
authors.lastname: Florholmen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002914:Chylomicrons / Q000737:chemistry; D005215:Fasting / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D064368:Healthy Volunteers; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009664:Norway; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D002914:Chylomicrons; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; C030087:lipoprotein triglyceride
keywords: Chylomicrons; fasting triglycerides; insulin resistance; metabolic healthy obese