title: [REGULATING EFFECT OF ASSOCIATIVE MICROBIOTA ON THE RHYTHMS OF BIOLOGICAL PROPERTIES OF FUNGI AND BACTERIA].
abstract: OBJECTIVE
  Study the effect of exometabolites of associative microbiota on circadian dynamics of functional parameters, that reflect pathogenic and persistence properties of fungi and bacteria.
  
  
  METHODS
  Clinical isolates of Candida albicans, isolated-from intestine of healthy individuals and patients with candidosis, as well as clinical isolates and museum ATCC strains Staphylococcus. aureus 25923, Escherichia coli 35218 and Pseudomonas aeruginosa 27853 were taken for study of proliferative, adhesive, catalase, protease, phospholipase, hemolytic, anti-lysozyme, biofilm-forming activity. The results were treated statistically.
  
  
  RESULTS
  C. albicans isolates, isolated from healthy individuals were revealed to be indifferent to the effect of bacterial metabolites. Chrono-infrastructure of biological properties of fungi altered under the effect of microbiota metabolites. Hospital isolates of S. aureus, E. coli and P. aeruginosa displayed a relative stability of physiological properties against the effect of bacterial-fungal metabolites as opposed to museum strains.
  
  
  CONCLUSIONS
  The alterations of chrono-infrastructure of biological rhythms of microorganisms by bacterial-fungal metabolites of associants reflect the intensity of the biological system, that is inevitable during the process of formation of inter-microbial interactions.
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Timokhina
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
authors.forename: M V
authors.initials: MV
authors.lastname: Nikolenko
authors.forename: Ya I
authors.initials: YI
authors.lastname: Paromova
authors.forename: N B
authors.initials: NB
authors.lastname: Perunova
mesh_terms: D002176:Candida albicans / Q000302:isolation & purification / Q000378:metabolism*; D004926:Escherichia coli / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D059013:Microbial Consortia; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000378:metabolism*