title: Synthesis of nano-hydroxyapatite and its rapid mediated surface functionalization by silane coupling agent.
abstract: In this work, hydroxyapatite (HA) nanorods were synthesized by simple one step wet precipitation method followed by their rapid surface functionalization via aminopropyltriethoxysilane (APTS) to give modified (HA-APTS) product. Functionalized hydroxyapatite (HA-APTS) holds amino groups on their surface that can be further functionalized with other bioactive molecules. The extent of functionalization of HA was studied under three different processing conditions; at room temperature, at 80 °C and under microwave condition (600 W). Three different temperatures have been use for the purpose of comparison between the functionalized products so that we can judge that whether there is any effect of temperature on the final products. In the last we conclude that temperature has no effect. So microwave condition is best to carried out the functionalization in just 5 min.
authors.affiliation: School of Chemical and Materials Engineering (SCME), National University of Sciences and Technology (NUST), H-12, Islamabad, ICT 44000, Pakistan. Electronic address: kknano@hotmail.com.
authors.forename: Sarish
authors.initials: S
authors.lastname: Rehman
authors.affiliation: School of Chemical and Materials Engineering (SCME), National University of Sciences and Technology (NUST), H-12, Islamabad, ICT 44000, Pakistan.
authors.forename: Kishwar
authors.initials: K
authors.lastname: Khan
authors.affiliation: School of Chemical and Materials Engineering (SCME), National University of Sciences and Technology (NUST), H-12, Islamabad, ICT 44000, Pakistan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mujahid
authors.affiliation: School of Chemical and Materials Engineering (SCME), National University of Sciences and Technology (NUST), H-12, Islamabad, ICT 44000, Pakistan.
authors.forename: Shaneela
authors.initials: S
authors.lastname: Nosheen
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008872:Microwaves; D036103:Nanotechnology; D043942:Nanotubes / Q000737:chemistry* / Q000633:toxicity; D010006:Osteoblasts / Q000187:drug effects; D011437:Propylamines; D012821:Silanes / Q000737:chemistry*; D013696:Temperature
chemical_list: D011437:Propylamines; D012821:Silanes; D017886:Durapatite; C477625:amino-propyl-triethoxysilane
keywords: APTS; Characterization; Functionalization; Hydroxyapatite; Microwave processing; Nanorods