title: Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine.
abstract: Psoriasis is a common, chronic inflammatory skin disease associated with multi-system manifestations including arthritis and obesity. Our knowledge of the aetiology of the condition, including the key genomic, immune and environmental factors, has led to the development of targeted, precision therapies that alleviate patient morbidity. This article reviews the key pathophysiological pathways and therapeutic targets and highlights future areas of interest in psoriasis research.
authors.affiliation: St. John's Institute of Dermatology, Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, UK.
authors.forename: Wisam
authors.initials: W
authors.lastname: Alwan
authors.affiliation: St. John's Institute of Dermatology, Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, UK. frank.nestle@kcl.ac.uk.
authors.forename: Frank O
authors.initials: FO
authors.lastname: Nestle
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D058990:Molecular Targeted Therapy; D018579:Patient Selection; D010641:Phenotype; D057285:Precision Medicine; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D012307:Risk Factors; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D005819:Genetic Markers