title: Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll.
abstract: Chromosomal instability (CIN) is a hallmark of cancer and has been implicated in cancer initiation, progression and the development of resistance to traditional cancer therapy. Here we identify a new property of CIN cells, showing that inducing CIN in proliferating Drosophila larval tissue leads to the activation of innate immune signalling in CIN cells. Manipulation of this immune pathway strongly affects the survival of CIN cells, primarily via JNK, which responds to both Toll and TNFα/Eiger. This pathway also activates Mmp1, which recruits hemocytes to the CIN tissue to provide local amplification of the immune response that is needed for effective elimination of CIN cells.
authors.affiliation: School of Biological Sciences, University of Adelaide, Adelaide, Australia.
authors.forename: Dawei
authors.initials: D
authors.lastname: Liu
authors.affiliation: School of Biological Sciences, University of Adelaide, Adelaide, Australia.
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Shaukat
authors.affiliation: School of Biological Sciences, University of Adelaide, Adelaide, Australia.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Saint
authors.affiliation: School of Biological Sciences, University of Adelaide, Adelaide, Australia.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Gregory
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D016923:Cell Death / Q000235:genetics / Q000276:immunology; D043171:Chromosomal Instability / Q000276:immunology*; D004330:Drosophila; D007113:Immunity, Innate; D018384:Oxidative Stress / Q000235:genetics / Q000276:immunology; D017382:Reactive Oxygen Species / Q000276:immunology; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology*
chemical_list: D017382:Reactive Oxygen Species; D051193:Toll-Like Receptors
keywords: Drosophila; Immune response; Immunity; Immunology Section; TLRs; TNFα; chromosomal instability; innate immune response