title: CT Pelvis in Children; Should We Routinely Scan Pelvis for Wilms Tumor and Hepatoblastoma? Implications for Imaging Protocol Development.
abstract: Wilms tumor and hepatoblastoma are the most common intra-abdominal solid organ childhood tumors. CT examination is one of the routinely performed procedures in hospitals for children with these tumors inspite of high radiation exposure associated with CT scans. Sixty patients (Wilms tumor = 45, hepatoblastoma = 16) were evaluated retrospectively. Higher proportion (44.4%) of metastatic disease was identified at presentation in the Wilms tumor subset as compared to hepatoblastoma (6.3%) [p=0.006]. Metastatic disease was noted in 6 patients having Wilms tumor on follow-up while it was also low in hepatoblastoma which was noted in only 2 patients (p > 0.05). No significant difference was identified in pelvic extension of disease at presentation in both studied population (p > 0.05). Pelvic metastasis was noted in 1 patient only with Wilms tumor on follow-up while no pelvic metastasis was seen in the hepatoblastoma patients (p-value > 0.05).
authors.affiliation: Department of Radiology, The Aga Khan University Hospital, Karachi.
authors.forename: Waseem
authors.initials: W
authors.lastname: Mirza
authors.affiliation: Department of Radiology, Great Ormond Street Hospital for Children, London, UK.
authors.forename: Kieran
authors.initials: K
authors.lastname: McHugh
authors.affiliation: Department of Public Health, University of Sheffield, Sheffield, UK.
authors.forename: Mubashir
authors.initials: M
authors.lastname: Aslam
authors.affiliation: Department of Radiology, The Aga Khan University Hospital, Karachi.
authors.forename: Zafar
authors.initials: Z
authors.lastname: Sajjad
authors.affiliation: Department of Radiology, The Aga Khan University Hospital, Karachi.
authors.forename: Waqas
authors.initials: W
authors.lastname: Abid
authors.affiliation: Department of Radiology, Great Ormond Street Hospital for Children, London, UK.
authors.forename: Talaat
authors.initials: T
authors.lastname: Youssef
authors.affiliation: Department of Research, Dow University, Karachi.
authors.forename: Arif
authors.initials: A
authors.lastname: Ali
authors.affiliation: Department of Oncology, The Aga Khan University Hospital, Karachi.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Fadoo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D018197:Hepatoblastoma / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008403:Mass Screening; D009362:Neoplasm Metastasis; D010386:Pelvic Neoplasms / Q000453:epidemiology / Q000473:pathology; D010388:Pelvis / Q000000981:diagnostic imaging*; D011829:Radiation Dosage; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D009396:Wilms Tumor / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology