title: Association of Serum Chemerin Levels with Acute Ischemic Stroke and Carotid Artery Atherosclerosis in a Chinese Population.
abstract: BACKGROUND
  The aim of this study was to examine the association between serum level of chemerin with AIS and carotid artery atherosclerosis, and to investigate the level of chemerin as a potential novel cerebrovascular risk factor.
  
  
  METHODS
  We compared the serum chemerin levels and cerebrovascular parameters between 70 AIS patients and 70 non-AIS subjects in a Chinese population. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of serum chemerin. The state of carotid artery plaques in the AIS group was detected by color Doppler ultrasound. We used SPSS software for statistical analysis.
  
  
  RESULTS
  Compared with the non-AIS group, serum level of chemerin in the AIS group increased significantly (p<0.01). Multivariable logistic regression suggested that serum chemerin level, neutrophil count, and BMI were independent risk factors for AIS (p<0.05). Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01). Multivariable logistic regression analysis revealed that the LDL-C, FIB, and serum chemerin levels were independent risk factors for carotid artery plaque instability (P<0.05). The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).
  
  
  CONCLUSIONS
  The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.
authors.affiliation: Department of Neurology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China (mainland).
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China (mainland).
authors.forename: Guorong
authors.initials: G
authors.lastname: Bi
authors.affiliation: 0.
authors.forename: Juan
authors.initials: J
authors.lastname: Feng
authors.affiliation: 0.
authors.forename: Rui
authors.initials: R
authors.lastname: Huang
authors.affiliation: 0.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Chen
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002339:Carotid Arteries / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000097:blood* / Q000208:ethnology; D018925:Chemokines / Q000097:blood*; D002681:China; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D007511:Ischemia / Q000097:blood* / Q000208:ethnology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000166:cytology; D012307:Risk Factors; D012984:Software; D020521:Stroke / Q000097:blood* / Q000208:ethnology; D018608:Ultrasonography, Doppler
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human