title: Evaluation of Left Ventricular Function and its Relationship With Multidimensional Grading System (BODE Index) in Patients With COPD.
abstract: Cardiovascular disease (CVD) is one of the main causes of morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients however data regarding left ventricle (LV) function in COPD is limited. We, in this study, aimed to evaluate the LV systolic function and its relation to BODE index in COPD patients with the utility of two-dimensional speckle tracking echocardiography (2D-STE). The study involved 125 COPD patients and 30 control subjects. All patients underwent 2D-echocardiography, pulmonary function tests and -minute walk tests. The patients were divided into four quartiles according to BODE index score. COPD patients had lower mitral annulus systolic velocity (Sm), average global longitudinal strain (GLS), average global longitudinal strain rate systolic (GLSRs), average GLSR early diastolic (GLSRe), average GLSR late diastolic (GLSRa), tricuspid annular plane systolic excursion (TAPSE) and peak systolic myocardial velocity (Sm-RV) (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001 and p = 0.002 respectively) than control subjects. There were significant differences between BODE index quartiles in terms of Sm, average GLS and average GLSRs. Patients were divided into two groups according to median value of GLS (> -18.6 and ≤ -18.6). BODE index quartiles were found to be independent predictors of decreased GLS in multivariate logistic regression analysis (p = 0.030). Increased BODE index was associated with impaired LV mechanics in patients with COPD.
authors.affiliation: a Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital , Department of Cardiology , Trabzon , Turkey.
authors.forename: Ezgi
authors.initials: E
authors.lastname: Kalaycıoğlu
authors.affiliation: b Kafkas University, Faculty of Medicine , Department of Cardiology , Kars , Turkey.
authors.forename: Tayyar
authors.initials: T
authors.lastname: Gökdeniz
authors.affiliation: a Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital , Department of Cardiology , Trabzon , Turkey.
authors.forename: Ahmet Çağrı
authors.initials: AÇ
authors.lastname: Aykan
authors.affiliation: a Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital , Department of Cardiology , Trabzon , Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Hatem
authors.affiliation: c Gaziemir Salih Nevvar gören State Hospital , Department of Cardiology , zmir , Turkey.
authors.forename: Mustafa Ozan
authors.initials: MO
authors.lastname: Gürsoy
authors.affiliation: d Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital , Department of Respiratory Medicine , Trabzon , Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Toksoy
authors.affiliation: a Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital , Department of Cardiology , Trabzon , Turkey.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Dursun
authors.affiliation: a Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital , Department of Cardiology , Trabzon , Turkey.
authors.forename: Sükrü
authors.initials: S
authors.lastname: Çelik
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology*; D012720:Severity of Illness Index; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014797:Vital Capacity
keywords: BODE index; COPD; left ventricle global longitudinal strain; two-dimensional speckle tracking echocardiography