title: Overexpression of Eg5 correlates with high grade astrocytic neoplasm.
abstract: To investigate the relationship between Eg5 and histopathological grade of astrocytoma, Eg5 expression was evaluated by immunohistochemical examination on 88 specimens including 25 cases of glioblastoma (WHO grade IV), 22 cases of anaplastic astrocytoma (WHO grade III), 20 cases of diffuse astrocytoma (WHO grade II), and 21 cases of pilocytic astrocytoma (WHO grade I). The histopathological characteristics and Eg5 expression level of each tumor were assessed and statistically analyzed. Astrocytic tumors exhibited significant correlation of expression of Eg5 with higher WHO histopathological grades (p < 0.001). Eg5 is expressed in 51-98% (mean 76.88%) of neoplastic cells in glioblastoma, 34-57% (mean 43.59%) of neoplastic cells in anaplastic astrocytoma, 6-36% (mean 18.60%) of neoplastic cells in diffuse astrocytoma, and 2-28% (mean 13.48%) of neoplastic cells in pilocytic astrocytoma. In conclusion, overexpression of Eg5 associates with high-grade astrocytic neoplasm, and it may represent an independent diagnostic and prognostic factor in grading astrocytic tumors and predicting prognosis of astrocytic tumor patients.
authors.affiliation: Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine, 1901 Perdido Street, New Orleans, LA, 70112, USA.
authors.forename: Liqiong
authors.initials: L
authors.lastname: Liu
authors.affiliation: Section of Neuropathology, Department of Pathology, Tulane University School of Medicine, 1430 Tulane Ave., SL-79, New Orleans, LA, 70112-2632, USA.
authors.forename: Xichun
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112-2632, USA.
authors.forename: Marcus
authors.initials: M
authors.lastname: Mare
authors.affiliation: Department of Neurosurgery, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112-2632, USA.
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Dumont
authors.affiliation: Section of Neuropathology, Department of Pathology, Tulane University School of Medicine, 1430 Tulane Ave., SL-79, New Orleans, LA, 70112-2632, USA.
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Structural and Cellular Biology, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA, 70112-2632, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Yan
authors.affiliation: Section of Neuropathology, Department of Pathology, Tulane University School of Medicine, 1430 Tulane Ave., SL-79, New Orleans, LA, 70112-2632, USA. zxiong@tulane.edu.
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Xiong
mesh_terms: D001253:Astrocytes / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019394:Ki-67 Antigen; D016547:Kinesins / Q000378:metabolism*; D008297:Male
chemical_list: C470243:KIF11 protein, human; D019394:Ki-67 Antigen; D016547:Kinesins
keywords: Astrocytic neoplasm; Eg5; Grading; Prognosis