title: Atherosclerotic Renal Artery Stenosis Prevalence and Correlations in Acute Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Interventions: Data From Nonrandomized Single-Center Study (REN-ACS)—A Single Center, Prospective, Observational Study.
abstract: BACKGROUND
  We are the first to evaluate the prevalence of renal artery stenosis (RAS) in consecutive patients with acute myocardial infarction (AMI) referred for primary percutaneous coronary intervention from a single tertiary center. As a novelty, we assessed hydration and metabolic status and measured arterial stiffness. We elaborated a predicting model for RAS in AMI.
  
  
  RESULTS
  One hundred and eighty-one patients with AMI underwent concomitantly primary percutaneous coronary intervention and renal angiography. We obtained data on demographics, medical history, cardiovascular risk factors, echocardiography, Killip class, and blood tests. In the first 24 hours post-primary percutaneous coronary intervention, we assessed bioimpedance through Body Composition Monitoring(®) and arterial stiffness through pulsed-wave velocity, SphygmoCor(®). Significant RAS (>50% lumen narrowing, RAS+) was present in 16.6% patients. In the RAS+ group we recorded significantly higher stiffness, CRUSADE score and dehydration, and more women with higher prevalence of multivascular coronary artery disease and heart failure. In our multivariate models, variables independently associated with RAS+ were previous percutaneous coronary intervention, low estimated glomerular filtration rate, multivascular coronary artery disease, and total/extracellular body water. These models had good specificity and low sensitivity.
  
  
  CONCLUSIONS
  We observed that RAS+ AMI patients have a particular hydration, metabolic, and endothelial profile that could generate more future major adverse cardiac events. Hence, renal angiography in AMI should be considered in specific subsets of patients.
  
  
  BACKGROUND
  URL: https://www.clinicaltrials.gov/. Unique identifier: NCT02388139.
authors.affiliation: Department of Interventional Cardiology, Cardiovascular Diseases Institute, Iasi, Romania (A.B., I.N.).
authors.forename: Alexandru
authors.initials: A
authors.lastname: Burlacu
authors.affiliation: Department of Nephrology, University of Medicine "Gr. T. Popa", Iasi, Romania (D.S., L.V., I.N., S.H., A.C.).
authors.forename: Dimitrie
authors.initials: D
authors.lastname: Siriopol
authors.affiliation: Department of Nephrology, University of Medicine "Gr. T. Popa", Iasi, Romania (D.S., L.V., I.N., S.H., A.C.).
authors.forename: Luminita
authors.initials: L
authors.lastname: Voroneanu
authors.affiliation: Department of Nephrology, University of Medicine "Gr. T. Popa", Iasi, Romania (D.S., L.V., I.N., S.H., A.C.).
authors.forename: Ionut
authors.initials: I
authors.lastname: Nistor
authors.affiliation: Department of Nephrology, University of Medicine "Gr. T. Popa", Iasi, Romania (D.S., L.V., I.N., S.H., A.C.).
authors.forename: Simona
authors.initials: S
authors.lastname: Hogas
authors.affiliation: Department of Cardiology, Cardiovascular Diseases Institute, Iasi, Romania (A.N.).
authors.forename: Ana
authors.initials: A
authors.lastname: Nicolae
authors.affiliation: Department of Interventional Cardiology, Cardiovascular Diseases Institute, Iasi, Romania (A.B., I.N.).
authors.forename: Igor
authors.initials: I
authors.lastname: Nedelciuc
authors.affiliation: Department of Cardiovascular Surgery, Cardiovascular Diseases Institute, Iasi, Romania (G.T.).
authors.forename: Grigore
authors.initials: G
authors.lastname: Tinica
authors.affiliation: Department of Nephrology, University of Medicine "Gr. T. Popa", Iasi, Romania (D.S., L.V., I.N., S.H., A.C.).
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D015995:Prevalence; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D012078:Renal Artery Obstruction / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D062606:Tertiary Care Centers; D016896:Treatment Outcome; D059289:Vascular Stiffness; D014882:Water-Electrolyte Balance
chemical_list: D015415:Biomarkers
keywords: angiography; arteries; hypertension; myocardial infarction; renal