title: Clinicopathological analysis of two cases with pelvis villous adenoma and review of relevant literature.
abstract: Villous adenoma is a rare primary tumor of the urinary system, especially the bladder and kidneys. This study presents two cases of right pelvis villous adenoma, including that of a 61-year-old patient who had experienced hematuria for more than 1 year and was diagnosed with bladder and ureteral stones via B-ultrasound examination, and the other one involving a 65-year-old patient who was hospitalized for 6 days due to a right upper quadrant mass and diagnosed with right renal pelvis stones and hydrops via B-ultrasound examination. Both patients underwent nephrectomy, and their histological analysis demonstrated papillary projections covered by columnar cells and goblet cells. The first patient had a large amount of renal pelvis mucus accumulation with obvious microscopic intestinal metaplasia and mild-moderate nuclear atypia. Immunohistochemical studies revealed positive carcinoembryonic antigen and the caudal type homeobox 2 staining with varying degrees of cytokeratin (CK)-7 and CK20 expression in both patients. Recurrences or metastasis was not observed during the follow-up period of 3-4 years.
authors.forename: Chunge
authors.initials: C
authors.lastname: Dong
authors.forename: Youping
authors.initials: Y
authors.lastname: Yang
authors.forename: Siying
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Pathology, The First People Hospital of Wenling, Wenling, 317500, China.
authors.forename: Guorong
authors.initials: G
authors.lastname: Chen
mesh_terms: D018253:Adenoma, Villous / Q000175:diagnosis* / Q000601:surgery; D000368:Aged; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000601:surgery; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D008875:Middle Aged