title: Diagnosis and Management of Thoracic Aortic Disease.
abstract: Thoracic aortic aneurysms are typically asymptomatic and discovered incidentally on an imaging study ordered for other indications. Small aneurysms are managed with antihypertensive therapy and surveillance imaging, using either echocardiography, computed tomographic angiography (CTA), or magnetic resonance angiography (MRA). Aneurysms are repaired when the risk of rupture or dissection exceeds the risk of repair; size thresholds for repair are determined by the underlying etiology of the aneurysm, with lower thresholds for those with genetic aortopathies. In contrast to the silent and asymptomatic nature of aneurysms, acute aortic syndromes-which include aortic dissection, intramural hematoma, and penetrating atherosclerotic ulcer-are usually associated with recognizable symptoms and signs. Acute aortic syndromes involving the ascending aorta are treated with emergent surgery, whereas those involving the descending aorta are now often treated with endovascular stent-grafting techniques. After acute aortic syndromes have been successfully treated, prognosis is favorable with close follow-up that includes optimal medical management and regular surveillance imaging.
authors.affiliation: Thoracic Aortic Center, Massachusetts General Hospital, Yawkey 5, Boston, MA, 02114, USA. ddudzinski@partners.org.
authors.forename: David M
authors.initials: DM
authors.lastname: Dudzinski
authors.affiliation: Thoracic Aortic Center, Massachusetts General Hospital, Yawkey 5, Boston, MA, 02114, USA. eisselbacher@partners.org.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Isselbacher
mesh_terms: D000784:Aortic Dissection / Q000175:diagnosis / Q000628:therapy; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001013:Aorta, Thoracic / Q000473:pathology / Q000503:physiopathology; D017545:Aortic Aneurysm, Thoracic / Q000175:diagnosis / Q000628:therapy; D001018:Aortic Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D001019:Aortic Rupture / Q000175:diagnosis / Q000628:therapy; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D004562:Electrocardiography; D057510:Endovascular Procedures / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000209:etiology; D018810:Magnetic Resonance Angiography; D010146:Pain / Q000209:etiology; D011379:Prognosis; D015607:Stents; D014057:Tomography, X-Ray Computed
chemical_list: D000959:Antihypertensive Agents
keywords: Acute aortic syndrome; Aorta; Aortic dissection; Intramural hematoma; Penetrating atherosclerotic ulcer; Thoracic aorta aneurysm