title: The long pentraxin-3 is a useful marker for diagnosis of ovarian torsion: An experimental rat model.
abstract: Pentraxin-3 (PTX3) plays an important role in the primary inflammatory response. We aim to evaluate PTX3 as a diagnostic marker of ovarian torsion in an experimental rat model. In this study, 16 female Sprague Dawley albino mature rats were randomly allocated to Group 1 (control, sham operated) and Group 2 (experimental ovarian torsion model). A torsion model was set up using atraumatic vascular clips just above and below the right ovary for a 3-h ischaemia. Blood samples were collected before and three hours after ovarian torsion. Three hours after ovarian torsion, right ovary was surgically removed for histopathological examination in both groups. There was no significant difference in preoperative PTX3 level in both groups (1.05 ± 0.20 ng/mL vs 1.09 ± 0.28 ng/mL, p > 0.05). Three hours after the operation, mean plasma level of PTX3 was significantly higher in ovarian torsion group than the control group (2.13 ± 0.49 ng/mL vs 1.07 ± 0.22 ng/mL, p = 0.001). Also, the mean total histopathological score was significantly increased in the torsion group. PTX3 can be used in clinical practice as a useful marker for early diagnosis of ovarian torsion.
authors.affiliation: a Department of Obstetrics and Gynecology , Ege University Medical School , Izmir , Turkey.|b Department of Stem Cell , Ege University, Institute of Health Sciences , Izmir , Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Akman
authors.affiliation: c Department of Physiology , Bilim University Medical School , Istanbul , Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Erbas
authors.affiliation: a Department of Obstetrics and Gynecology , Ege University Medical School , Izmir , Turkey.
authors.forename: M C
authors.initials: MC
authors.lastname: Terek
authors.affiliation: d Department of Histology and Embryology , Ege University Medical School , Izmir , Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Aktug
authors.affiliation: e Department of Physiology , Ege University Medical School , Izmir , Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Taskiran
authors.affiliation: a Department of Obstetrics and Gynecology , Ege University Medical School , Izmir , Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Askar
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D010049:Ovarian Diseases / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D010053:Ovary / Q000473:pathology; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D014102:Torsion Abnormality / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
keywords: PTX3; Pentraxin-3; biochemical marker; diagnosis; ovarian torsion; rat model