title: Thermally processed polymeric microparticles for year-long delivery of dexamethasone.
abstract: Dexamethasone-releasing poly(lactic-co-glycolic acid) (PLGA) microparticles were formulated using a solvent displacement technique with the addition of distillation aiming to increase drug delivery lifetime. Two PLGA copolymer ratios (50:50 and 75:25) were used to determine the influence of lactic acid and glycolic acid ratio on microparticle characteristics. The addition of distillation significantly slows the release of dexamethasone compared to traditional solvent removal via evaporation while still maintaining a therapeutic dosage. Microparticles formulated with PLGA 50:50 controllably release dexamethasone up to one year and 75:25 release up to two years in-vitro. The ratio of lactic acid to glycolic acid plays a significant role in microparticle stability, drug loading efficiency, and thermal properties. In all, this formulation technique offers new prospects for inflammation suppression in pediatric vascular and airway diseases.
authors.affiliation: Division of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9130, USA.
authors.forename: Amy C
authors.initials: AC
authors.lastname: Goodfriend
authors.affiliation: Division of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9130, USA.
authors.forename: Tré R
authors.initials: TR
authors.lastname: Welch
authors.affiliation: Department of Bioengineering, University of Texas Arlington, Arlington, TX 76019, USA.
authors.forename: Kytai T
authors.initials: KT
authors.lastname: Nguyen
authors.affiliation: Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9130, USA.
authors.forename: Romaine F
authors.initials: RF
authors.lastname: Johnson
authors.affiliation: Division of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9130, USA.
authors.forename: Vinod
authors.initials: V
authors.lastname: Sebastian
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9130, USA.
authors.forename: Surendranath Veeram
authors.initials: SV
authors.lastname: Reddy
authors.affiliation: Division of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9130, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Forbess
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9130, USA. Electronic address: Alan.Nugent@utsouthwestern.edu.
authors.forename: Alan
authors.initials: A
authors.lastname: Nugent
mesh_terms: D002626:Chemistry, Pharmaceutical; D003907:Dexamethasone / Q000737:chemistry* / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D006358:Hot Temperature; D019344:Lactic Acid / Q000737:chemistry*; D008863:Microspheres; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003907:Dexamethasone
keywords: Dexamethasone; Drug delivery; PLGA microparticles; Thermal processing