title: Relationship between Stereoscopic Vision, Visual Perception, and Microstructure Changes of Corpus Callosum and Occipital White Matter in the 4-Year-Old Very Low Birth Weight Children.
abstract: OBJECTIVE
  To assess the relationship between stereoscopic vision, visual perception, and microstructure of the corpus callosum (CC) and occipital white matter, 61 children born with a mean birth weight of 1024 g (SD 270 g) were subjected to detailed ophthalmologic evaluation, Developmental Test of Visual Perception (DTVP-3), and diffusion tensor imaging (DTI) at the age of 4.
  
  
  RESULTS
  Abnormal stereoscopic vision was detected in 16 children. Children with abnormal stereoscopic vision had smaller CC (CC length: 53 ± 6 mm versus 61 ± 4 mm; p < 0.01; estimated CC area: 314 ± 106 mm(2) versus 446 ± 79 mm(2); p < 0.01) and lower fractional anisotropy (FA) values in CC (FA value of rostrum/genu: 0.7 ± 0.09 versus 0.79 ± 0.07; p < 0.01; FA value of CC body: 0.74 ± 0.13 versus 0.82 ± 0.09; p = 0.03). We found a significant correlation between DTVP-3 scores, CC size, and FA values in rostrum and body. This correlation was unrelated to retinopathy of prematurity.
  
  
  CONCLUSIONS
  Visual perceptive dysfunction in ex-preterm children without major sequelae of prematurity depends on more subtle changes in the brain microstructure, including CC. Role of interhemispheric connections in visual perception might be more complex than previously anticipated.
authors.affiliation: Department of Pediatrics, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Przemko
authors.initials: P
authors.lastname: Kwinta
authors.affiliation: Department of Electroradiology, Jagiellonian University, Michalowskiego 12, 31-126 Cracow, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Herman-Sucharska
authors.affiliation: Department of Opthalmology and Ocular Oncology, Jagiellonian University, Kopernika 36, 31-501 Cracow, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Leśniak
authors.affiliation: Department of Pediatrics, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Klimek
authors.affiliation: Department of Electroradiology, Jagiellonian University, Michalowskiego 12, 31-126 Cracow, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Karcz
authors.affiliation: Department of Pediatrics, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Durlak
authors.affiliation: Department of Applied Psychology and Human Development, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Nitecka
authors.affiliation: Department of Applied Psychology and Human Development, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Dutkowska
authors.affiliation: Department of Opthalmology and Ocular Oncology, Jagiellonian University, Kopernika 36, 31-501 Cracow, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Kubatko-Zielińska
authors.affiliation: Department of Opthalmology and Ocular Oncology, Jagiellonian University, Kopernika 36, 31-501 Cracow, Poland.
authors.forename: Bożena
authors.initials: B
authors.lastname: Romanowska-Dixon
authors.affiliation: Department of Pediatrics, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Jacek Józef
authors.initials: JJ
authors.lastname: Pietrzyk
mesh_terms: D002675:Child, Preschool; D015897:Comorbidity; D003337:Corpus Callosum / Q000473:pathology*; D003867:Depth Perception; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D009778:Occipital Lobe / Q000473:pathology*; D010468:Perceptual Disorders / Q000175:diagnosis / Q000453:epidemiology*; D011044:Poland / Q000453:epidemiology; D012307:Risk Factors; D014786:Vision Disorders / Q000175:diagnosis / Q000453:epidemiology*; D014792:Visual Acuity; D014796:Visual Perception; D066127:White Matter / Q000473:pathology*