title: Advantage and limitations of nitrofurantoin in multi-drug resistant Indian scenario.
abstract: Infections caused by antibiotic resistant pathogens are of significant concern and are associated with higher mortality and morbidity. Nitrofurantoin is a broad-spectrum bactericidal antibiotic and is effectively used to treat urinary tract infections (UTIs) caused by E. coli, Klebsiella sp., Enterobacter sp., Enterococcus sp. and Staphylococcus aureus. It interfere with the synthesis of cell wall, bacterial proteins and DNA of both Gram positive and Gram negative pathogens. Nitrofurantoin has been used successfully for treatment and prophylaxis of acute lower urinary tract infections. With the emergence of antibiotic resistance, nitrofurantoin has become the choice of agent for treating UTIs caused by multi-drug resistant pathogens.
authors.forename: Laishram
authors.initials: L
authors.lastname: Shakti
authors.affiliation: Department of Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Balaji
authors.initials: B
authors.lastname: Veeraraghavan
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D018890:Chemoprevention / Q000379:methods*; D024901:Drug Resistance, Multiple, Bacterial; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007194:India; D009582:Nitrofurantoin / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D009582:Nitrofurantoin