title: Structure-function Relationships in Uveitic Cystoid Macular Edema: Using En Face Optical Coherence Tomography to Predict Vision.
abstract: OBJECTIVE
  To explore whether preserved retinal tissue on baseline en face optical coherence tomography (OCT) correlates with post-treatment visual acuity in patients with uveitis-associated cystoid macular edema (CME).
  
  
  METHODS
  A retrospective cohort study was conducted on 25 eyes (23 patients) with uveitis and CME, with resolution of CME at post-treatment follow-up. Baseline en face OCT images were analyzed to determine the proportion of pixels representing preserved retinal tissue. Macular thickness and volume data were also analyzed.
  
  
  RESULTS
  The proportion of preserved retinal tissue on baseline OCT strongly correlated with baseline visual acuity (r = 0.61, p = 0.0014), and correlated even better with vision after CME resolution (r = 0.73, p < 0.0001). Weak correlations were found between macular thickness and volume at baseline and post-treatment acuity (r = 0.38, p = 0.058 and r = 0.39, p = 0.055).
  
  
  CONCLUSIONS
  Preserved retinal tissue at baseline strongly correlates with post-treatment visual acuity in patients with uveitis-associated CME, and is a better predictor of future vision than macular thickness or volume.
authors.affiliation: a Department of Ophthalmology , Northwestern University Feinberg School of Medicine , Chicago , Illinois , USA.
authors.forename: Liza M
authors.initials: LM
authors.lastname: Cohen
authors.affiliation: a Department of Ophthalmology , Northwestern University Feinberg School of Medicine , Chicago , Illinois , USA.
authors.forename: Debra A
authors.initials: DA
authors.lastname: Goldstein
authors.affiliation: a Department of Ophthalmology , Northwestern University Feinberg School of Medicine , Chicago , Illinois , USA.
authors.forename: Amani A
authors.initials: AA
authors.lastname: Fawzi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008269:Macular Edema / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014605:Uveitis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult
chemical_list: D020533:Angiogenesis Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids
keywords: Cystoid macular edema; image analysis; optical coherence tomography; retina; uveitis