title: Anticoagulation for renal replacement therapy for patients with acute kidney injury.
abstract: Patients with acute kidney injury are generally prothrombotic, and as such prone to increased risk of clotting in extracorporeal renal replacement therapy (RRT) circuits. Although some patients may be adequately treated by intermittent RRT, however due to cardiovascular instability many patients are treated by continuous renal replacement therapy (CCRT) or prolonged intermittent renal replacement therapy (PIRRT). Clotting in the RRT circuit not only reduces the efficiency of solute clearances, affects fluid balance, but also has economic health care costs. The longer duration RRT modes, CRRT and PIRRT are more prone to clotting, and more dependent on adequate anticoagulation. This review will compare the currently available systemic and regional anticoagulation options for CRRT and PIRRT for the patient with acute kidney injury.
authors.affiliation: Renal Unit, Department of Medicine Faculty of Medicine, Ramathibodi Hospital Mahidol University, Bangkok, Thailand - oatega@yahoo.com.
authors.forename: Arkom
authors.initials: A
authors.lastname: Nongnuch
authors.forename: Viratch
authors.initials: V
authors.lastname: Tangsujaritvijit
authors.forename: Andrew
authors.initials: A
authors.lastname: Davenport
mesh_terms: D058186:Acute Kidney Injury / Q000401:mortality / Q000628:therapy*; D000925:Anticoagulants / Q000627:therapeutic use*; D000991:Antithrombins / Q000627:therapeutic use; D019343:Citric Acid / Q000627:therapeutic use; D006493:Heparin / Q000031:analogs & derivatives / Q000627:therapeutic use; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006496:Heparinoids / Q000627:therapeutic use; D006801:Humans; D007362:Intensive Care Units; D011453:Prostaglandins / Q000627:therapeutic use; D017582:Renal Replacement Therapy; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D006495:Heparin, Low-Molecular-Weight; D006496:Heparinoids; D011453:Prostaglandins; D015842:Serine Proteinase Inhibitors; C078918:ITF 300; D019343:Citric Acid; D006493:Heparin