title: Influence of Cu doping in borosilicate bioactive glass and the properties of its derived scaffolds.
abstract: Copper doped borosilicate glasses (BG-Cu) were studied by means of FT-IR, Raman, UV-vis and NMR spectroscopies to investigate the changes that appeared in the structure of borosilicate glass matrix by doping copper ions. Micro-fil and immunohistochemistry analysis were applied to study the angiogenesis of its derived scaffolds in vivo. Results indicated that the Cu ions significantly increased the B-O bond of BO4 groups at 980 cm(-1), while they decrease that of BO2O(-) groups at 1440-1470 cm(-1) as shown by Raman spectra. A negative shift was observed from (11)B and (29)Si NMR spectra. The (11)B NMR spectra exhibited a clear transformation from BO3 into BO4 groups, caused by the agglutination effect of the Cu ions and the charge balance of the agglomerate in the glass network, leading to a more stable glass network and lower ions release rate in the degradation process. Furthermore, the BG-Cu scaffolds significantly enhanced blood vessel formation in rat calvarial defects at 8 weeks post-implantation. Generally, it suggested that the introduction of Cu into borosilicate glass endowed glass and its derived scaffolds with good properties, and the cooperation of Cu with bioactive glass may pave a new way for tissue engineering.
authors.affiliation: School of Materials Science and Engineering, Tongji University, Shanghai 2001804, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Shichang
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Materials Science and Engineering, and Center for Biomedical Science and Engineering, Missouri University of Science and Technology, Rolla, MO 65409-0340, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Chemistry, Tongji University, Shanghai 200092, China.
authors.forename: Jingzhe
authors.initials: J
authors.lastname: Xue
authors.affiliation: Department of Materials Science and Engineering, and Center for Biomedical Science and Engineering, Missouri University of Science and Technology, Rolla, MO 65409-0340, USA.
authors.forename: Youqu
authors.initials: Y
authors.lastname: Shen
authors.affiliation: School of Materials Science and Engineering, Tongji University, Shanghai 2001804, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Materials Science and Engineering, Tongji University, Shanghai 2001804, China.
authors.forename: Wenhai
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Materials Science and Engineering, and Center for Biomedical Science and Engineering, Missouri University of Science and Technology, Rolla, MO 65409-0340, USA.
authors.forename: Mohamed N
authors.initials: MN
authors.lastname: Rahaman
authors.affiliation: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China. Electronic address: shzhangchangqing@163.com.
authors.forename: Changqing
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Materials Science and Engineering, Tongji University, Shanghai 2001804, China. Electronic address: wdpshk@tongji.edu.cn.
authors.forename: Deping
authors.initials: D
authors.lastname: Wang
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D001895:Boron / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D018919:Neovascularization, Physiologic; D051381:Rats; D017207:Rats, Sprague-Dawley; D017640:Silicates / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D017640:Silicates; D003300:Copper; D001895:Boron
keywords: Biodegradation; Borosilicate glass; Copper doping; Glass network; Glass scaffolds