title: Why Build Whole-Cell Models?
abstract: Our ability to build computational models that account for all known gene functions in a cell has increased dramatically. But why build whole-cell models, and how can they best be used? In this forum, we enumerate several areas in which whole-cell modeling can significantly impact research and technology.
authors.affiliation: Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, CA 94305-4125, USA.
authors.forename: Javier
authors.initials: J
authors.lastname: Carrera
authors.affiliation: Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, CA 94305-4125, USA. Electronic address: mcovert@stanford.edu.
authors.forename: Markus W
authors.initials: MW
authors.lastname: Covert
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena / Q000502:physiology*; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D008954:Models, Biological
keywords: model-driven discovery; predictive biology; whole-cell modeling