title: Functional regulation of FoxO1 in neural stem cell differentiation.
abstract: Forkhead transcription factor family O (FoxO) maintains adult stem cell reserves by supporting their long-term proliferative potential. MicroRNAs (miRs) regulate neuronal stem/progenitor cell (NSPC) proliferation and differentiation during neural development by controlling the expression of a specific set of target genes. In the neurogenic subventricular zone, FoxO1 is specifically expressed in NSPCs and is no longer detected during the transition to neuroblast stage, forming an inverse correlation with miR-9 expression. The 3'-untranslated region of FoxO1 contains a conserved target sequence of miR-9 and FoxO1 expression is coordinated in concert with miR-9 during neuronal differentiation. Our study demonstrates that FoxO1 contributes to NSPC fate decision through its cooperation with the Notch signaling pathway.
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, USA.|Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: D-Y
authors.initials: DY
authors.lastname: Kim
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, USA.
authors.forename: I
authors.initials: I
authors.lastname: Hwang
authors.affiliation: Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: F L
authors.initials: FL
authors.lastname: Muller
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, USA.
authors.forename: J-H
authors.initials: JH
authors.lastname: Paik
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D002478:Cells, Cultured; D000089622:Doublecortin Domain Proteins; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D064231:Nestin / Q000235:genetics / Q000378:metabolism; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D015398:Signal Transduction; D014404:Tubulin / Q000235:genetics / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; D000089622:Doublecortin Domain Proteins; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; C467200:Foxo1 protein, mouse; C551804:MIRN9 microRNA, mouse; D035683:MicroRNAs; D008869:Microtubule-Associated Proteins; D064231:Nestin; D009479:Neuropeptides; D051880:Receptors, Notch; D014404:Tubulin