title: The cellular basis of hybrid dysgenesis and Stellate regulation in Drosophila.
abstract: During normal tissue development, the accumulation of unrepaired cellular and genomic damage can impair growth and ultimately leads to death. To preserve cellular integrity, cells employ a number of defense mechanisms including molecular checkpoints, during which development is halted while dedicated pathways attempt repair. This process is most critical in germline tissues where cellular damage directly threatens an organism's reproductive capacity and offspring viability. In the fruit fly, Drosophila melanogaster, germline development has been extensively studied for over a century and the breadth of our knowledge has flourished in the genomics age. Intriguingly, several peculiar phenomena that trigger catastrophic germline damage described decades ago, still endure only a partial understanding of the underlying molecular causes. A deeper reexamination using new molecular and genetic tools may greatly benefit our understanding of host system biology. Among these, and the focus of this concise review, are hybrid dysgenesis and an intragenomic conflict that pits the X and Y sex chromosomes against each other.
authors.affiliation: Howard Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: Colin.Dean.Malone@gmail.com.
authors.forename: Colin D
authors.initials: CD
authors.lastname: Malone
authors.affiliation: Howard Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Ruth
authors.initials: R
authors.lastname: Lehmann
authors.affiliation: Howard Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: Felipe.Teixeira@med.nyu.edu.
authors.forename: Felipe Karam
authors.initials: FK
authors.lastname: Teixeira
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development*; D005854:Germ Cells / Q000254:growth & development* / Q000378:metabolism / Q000473:pathology; D006059:Gonadal Dysgenesis / Q000235:genetics* / Q000473:pathology; D011494:Protein Kinases / Q000235:genetics*; D012730:Sex Chromosomes / Q000235:genetics; D049490:Systems Biology
chemical_list: D029721:Drosophila Proteins; D011494:Protein Kinases; C094331:Ste protein, Drosophila