title: Chemical derivatization in LC-MS bioanalysis: current & future challenges.
authors.affiliation: Pharmaceutical Research Laboratories, Nippon Kayaku Co., Ltd., 3-31-12, Shimo, Kita-ku, Tokyo, 115-8588, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Niwa
authors.affiliation: Pharmaceutical Research Laboratories, Nippon Kayaku Co., Ltd., 3-31-12, Shimo, Kita-ku, Tokyo, 115-8588, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Pharmaceutical Research Laboratories, Nippon Kayaku Co., Ltd., 3-31-12, Shimo, Kita-ku, Tokyo, 115-8588, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Watanabe
mesh_terms: D056246:Chemistry, Analytic / Q000639:trends*; D002851:Chromatography, High Pressure Liquid; D057930:Click Chemistry; D056831:Coordination Complexes / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism; D013739:Testosterone / Q000032:analysis / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D004364:Pharmaceutical Preparations; D013739:Testosterone
keywords: analytical chemistry; chemical derivatization; click chemistry; laser capture microdissection; liquid extraction surface analysis