title: Toward a rational design of combination therapy in cancer.
abstract: By merging computational systems modeling and experimental approaches, we have uncovered treatments reprogramming pro-angiogenic monocytes present in breast tumor into immunologically potent cells capable of mediating an anti-tumor immune response. The unraveled pathways and ligands which underlie monocyte pro-angiogenic activity have a strong predictive value for breast cancer patient relapse - free survival.
authors.affiliation: Ludwig Center for Cancer Research; University of Lausanne ; Epilanges, Switzerland.
authors.forename: Marie-Agnès
authors.initials: MA
authors.lastname: Doucey
authors.affiliation: Vital-IT Systems Biology Division; SIB Swiss Institute of Bioinformatics; University of Lausanne ; Lausanne, Switzerland.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Xenarios
keywords: angiogenesis, monocytes, immune suppression, breast cancer, modeling