title: Resveratrol: A potential challenger against gastric cancer.
abstract: Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer-related mortality in the world. Late diagnosis and classical therapeutic approaches such as surgery, chemotherapy and radiotherapy make this disease a still threatening tumor. Genetic asset, environmental stress, dietary habit and infections caused by Helicobacter pylori (H. pylori) are the major causes concurring to GC initiation. A common mechanism is induction of radicals resulting in gastric mucosal injury. A regular food intake of antioxidant and radical scavenging agents has been proposed to exert protection against tumorigenesis. Resveratrol belongs to the polyphenol flavonoids class of antioxidants produced by a restricted number of plants. Resveratrol exerts bactericidal activity against H. pylori and is a powerful antioxidant, thus acting as a tumor preventive agent. Resveratrol intracellular signaling results in growth arrest and apoptosis, so that it can be directed against tumor progression. Resveratrol therapeutic potential against GC initiation and progression are reviewed here.
authors.affiliation: Aida Zulueta, Anna Caretti, Paola Signorelli, Riccardo Ghidoni, Department of Health Sciences, San Paolo Hospital, University of Milan, 20142 Milano, Italy.
authors.forename: Aida
authors.initials: A
authors.lastname: Zulueta
authors.affiliation: Aida Zulueta, Anna Caretti, Paola Signorelli, Riccardo Ghidoni, Department of Health Sciences, San Paolo Hospital, University of Milan, 20142 Milano, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Caretti
authors.affiliation: Aida Zulueta, Anna Caretti, Paola Signorelli, Riccardo Ghidoni, Department of Health Sciences, San Paolo Hospital, University of Milan, 20142 Milano, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Signorelli
authors.affiliation: Aida Zulueta, Anna Caretti, Paola Signorelli, Riccardo Ghidoni, Department of Health Sciences, San Paolo Hospital, University of Milan, 20142 Milano, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ghidoni
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents; D000975:Antioxidants / Q000627:therapeutic use; D017209:Apoptosis; D002453:Cell Cycle; D049109:Cell Proliferation; D016922:Cellular Senescence; D004032:Diet; D018450:Disease Progression; D044127:Epigenesis, Genetic; D016480:Helicobacter pylori; D006801:Humans; D008019:Life Style; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D059808:Polyphenols; D011788:Quality of Life; D000077185:Resveratrol; D015398:Signal Transduction; D013267:Stilbenes / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol
keywords: Apoptosis; Cell cycle; Diet; Gastric cancer; Polyphenols; Resveratrol