title: Genetic Polymorphism of Cytochrome p450 (2C9) Enzyme in Iranian Baluch Ethnic Group.
abstract: The aim of the present study is to assess and compare the frequencies of the cytochrome P450 CYP2C9 variations in the Baluch ethnic group (n=110) with other ethnic groups. The allele frequencies of CYP2C9*1, CYP2C9*2 and CYP2C9*3 were 80.90%, 11.82% and 7.27%, respectively. 70.90%, 11.82%, 8.18%, 4.55%, 2.73% and 1.82% of subjects were with CYP2C9*1/*1, CYP2C9*1/*2, CYP2C9*1/*3, CYP2C9*2/*2, CYP2C9*2/*3 and CYP2C9*3/*3 genotypes, respectively. Different mutants may effect on prediction of drug dose requirements in different ethnic groups. Thus, CYP2C9 variants to be determined for findings high risk groups use optimal dosage of drugs metabolized by this polymorphic enzyme.
authors.affiliation: Babol University of Medicine Sciences, Babol, Mazandaran province, Iran.
authors.forename: Mojdeh Ghiyas
authors.initials: MG
authors.lastname: Tabari
authors.affiliation: Chabahar-Sistane and Baluchestan Province, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Naseri
authors.affiliation: Fatima Alzahra Hospital Minodasht, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Maryam Agh
authors.initials: MA
authors.lastname: Ataby
authors.affiliation: Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan province, Iran.
authors.forename: Abdoljalal
authors.initials: A
authors.lastname: Marjani
keywords: Baluch ethnic group; CYP2C9 genetic polymorphism; polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP)