title: Single- versus multiple-port thoracoscopic lobectomy for lung cancer: a propensity-matched study†.
abstract: OBJECTIVE
  In this retrospective study, we aimed to compare single-port (SP) and multiport (MP) video-assisted thoracoscopic surgery (VATS) for the surgical resection of non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  Between October 2013 and October 2014, a total of 411 consecutive NSCLC patients who underwent VATS lobectomy in the Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, were enrolled. Propensity-matched analysis, incorporating preoperative clinical features, was used to compare the perioperative outcomes and analyse the safety and efficacy between SP and MP VATS lobectomies for NSCLCs.
  
  
  RESULTS
  There were 115 patients in the SP group, and 296 patients in the MP group from October 2013 to October 2014. Propensity matching produced 100 pairs in this retrospective study. During the operation, the lobectomy took less time in the SP than in the MP (65.7 ± 14.8 vs 81.3 ± 13.6, P < 0.001) group, while the duration of lymphadenectomy was longer in the SP group (29.6 ± 16.7 vs 17.4 ± 13.3, P < 0.001). The total operation duration, the volume of estimated blood loss (55.1 ± 9.0 ml vs 58.7 ± 7.1 ml, P = 0.22) and the length of postoperative hospital stay (4.7 ± 1.2 days vs 5.3 ± 1.4 days, P = 0.05) were similar between the two groups. Postoperatively, SP and MP groups showed similar results in terms of morbidity and mortality.
  
  
  CONCLUSIONS
  In comparison with conventional VATS, SP VATS lobectomy showed better safety and efficacy in the surgical resection of NSCLCs. Further studies based on larger populations and better methodology are required to determine its further benefits towards patients.
authors.affiliation: Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Yaxing
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Mingxiang
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xi
authors.affiliation: Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, China tan.lijie@zs-hospital.sh.cn.
authors.forename: Lijie
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods*; D057216:Propensity Score; D012189:Retrospective Studies; D020775:Thoracic Surgery, Video-Assisted / Q000379:methods*; D016896:Treatment Outcome
keywords: Lung cancer; Uniportal surgery; Video-assisted thoracic surgery