title: Cytotoxicity on Allium cepa of the two main sulcotrione photoproducts, xanthene-1,9-dione-3,4-dihydro-6-methylsulphonyl and 2-chloro-4-mesylbenzoic acid.
abstract: The cytotoxic effects of 2-chloro-4-mesylbenzoic acid (CMBA) and xanthene-1,9-dione-3,4-dihydro-6-methylsulphonyl (XDD), the two main photoproducts of sulcotrione, were investigated on Allium root meristematic cells at different concentrations. Degradation of sulcotrione was correlated to mitotic index decrease, together with increasing anomaly and c-mitosis frequencies. Mitotic index significantly decreased with increasing XDD and CMBA concentrations. Cell frequency with abnormal chromosomes increased with CMBA or XDD application rates. In contrast, CMBA induced a low micronucleus rate even for high concentrations while XDD increased the micronucleus ratio. C-mitoses, chromosomal aberrations due to an inactivation of the spindle, were enhanced by CMBA treatments but not by XDD. The photochemical degradation process of the pesticide can change the risk for the environment.
authors.affiliation: Clermont Université, UMR 547-UBP/INRA PIAF, Université Blaise Pascal, Campus universitaire des Cézeaux, 24, avenue des Landais, 63177 Aubière cedex, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Goujon
authors.affiliation: CNRS, UMR 6296, ICCF, F-63171 Aubière, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Richard
authors.affiliation: Clermont Université, UMR 547-UBP/INRA PIAF, Université Blaise Pascal, Campus universitaire des Cézeaux, 24, avenue des Landais, 63177 Aubière cedex, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Goupil
authors.affiliation: Clermont Université, UMR 547-UBP/INRA PIAF, Université Blaise Pascal, Campus universitaire des Cézeaux, 24, avenue des Landais, 63177 Aubière cedex, France. Electronic address: gerard.ledoigt@univ-bpclermont.fr.
authors.forename: Gérard
authors.initials: G
authors.lastname: Ledoigt
mesh_terms: D000490:Allium / Q000187:drug effects* / Q000235:genetics; D003512:Cyclohexanones / Q000737:chemistry* / Q000633:toxicity*; D006540:Herbicides / Q000737:chemistry* / Q000633:toxicity; D008698:Mesylates / Q000737:chemistry* / Q000633:toxicity*; D015162:Micronucleus Tests; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index; D010782:Photolysis
chemical_list: D003512:Cyclohexanones; D006540:Herbicides; D008698:Mesylates; C079906:sulcotrione
keywords: Allium cepa; Genotoxicity; Pesticide; Photolysis; Sulcotrione