title: Salivary botulinum toxin injection may reduce aspiration pneumonia in neurologically impaired children.
abstract: OBJECTIVE
  Neurologically impaired children often drool and aspirate saliva leading to recurrent aspiration pneumonia and frequent hospitalizations. Salivary botulinum toxin injection is known to reduce sialorrhea. This study evaluates whether this intervention affects the frequency and duration of respiratory infections including aspiration pneumonia and hospitalizations in neurologically impaired children.
  
  
  METHODS
  Retrospective review of patients treated with salivary botulinum toxin at a tertiary care pediatric hospital from January 2009 to December 2013. Each patient was their own control and 180 day pre-injection and post-injection time periods were compared. Outcomes evaluated included: number of hospital days, intensive care unit days, days of antibiotic treatment, chest X-rays, and infiltrates on chest X-ray.
  
  
  RESULTS
  13 patients accumulated 539 hospital days. All children were gastrostomy tube dependent. 54% were tracheostomy tube dependent. Amongst all patients, the total hospital days decreased from 385 to 154 (P=0.02), the mean days treated with antibiotics decreased from 214 to 47 (P=0.02), and the number of chest X-ray confirmed infiltrates decreased from 20 to 6 (P=0.02) after injection.
  
  
  CONCLUSIONS
  In this review, there was a decrease in hospitalized days, antibiotic usage, and chest X-ray infiltrates after the salivary botulinum toxin injection. A prospective study is needed to evaluate whether this treatment can prevent aspiration pneumonia in neurologically impaired children.
authors.affiliation: Department of Otolaryngology, State University of New York at Buffalo, 1237 Delaware Avenue, Buffalo, NY 14209, USA.
authors.forename: John
authors.initials: J
authors.lastname: Faria
authors.affiliation: Department of Otolaryngology, State University of New York at Buffalo, 1237 Delaware Avenue, Buffalo, NY 14209, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Harb
authors.affiliation: Department of Otolaryngology, State University of New York at Buffalo, 1237 Delaware Avenue, Buffalo, NY 14209, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Hilton
authors.affiliation: Pediatric Interventional Radiology, Women and Children's Hospital of Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA.
authors.forename: Dean
authors.initials: D
authors.lastname: Yacobucci
authors.affiliation: Department of Otolaryngology, State University of New York at Buffalo, 1237 Delaware Avenue, Buffalo, NY 14209, USA. Electronic address: mpizzutomd@gmail.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Pizzuto
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008297:Male; D009422:Nervous System Diseases / Q000150:complications*; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011015:Pneumonia, Aspiration / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D011859:Radiography; D012008:Recurrence; D053120:Respiratory Aspiration / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D012463:Saliva / Q000378:metabolism; D012469:Salivary Glands; D012798:Sialorrhea / Q000150:complications / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A
keywords: Aspiration pneumonia; Drooling; Salivary botulinum toxin; Sialorrhea