title: Responses of the Ocular Anterior Segment and Refraction to 0.5% Tropicamide in Chinese School-Aged Children of Myopia, Emmetropia, and Hyperopia.
abstract: Purpose. To investigate the changes of anterior segment after cycloplegia and estimate the association of such changes with the changes of refraction in Chinese school-aged children of myopia, emmetropia, and hyperopia. Methods. 309 children were recruited and eligible subjects were assigned to three groups: hyperopia, emmetropia, or myopia. Cycloplegia was achieved with five cycles of 0.5% tropicamide. The Pentacam system was used to measure the parameters of interest before and after cycloplegia. Results. In the myopic group, the lenses were thinner and the lens position was significantly more posterior than that of the emmetropic and hyperopic groups in the cycloplegic status. The correlations between refraction and lens thickness (age adjusted; r = 0.26, P < 0.01), and lens position (age adjusted; r = -0.31, P < 0.01) were found. After cycloplegia, ACD and ACV significantly increased, while ACA significantly decreased. Changes in refraction, ACD, ACV, and ACA were significantly different among the three groups (P < 0.05, all). Changes of refraction were correlated with changes of ACD (r = 0.41, P < 0.01). Conclusions. Myopia presented thinner lenses and smaller changes of anterior segment and refraction after cycloplegia when compared to emmetropia and hyperopia. Changes of anterior chamber depth were correlated with refraction changes. This may contribute to a better understanding of the relationship between anterior segment and myopia.
authors.affiliation: Shanghai Eye Disease Prevention & Treatment Center, Shanghai 200040, China ; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Shanghai Eye Disease Prevention & Treatment Center, Shanghai 200040, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Shanghai Eye Disease Prevention & Treatment Center, Shanghai 200040, China.
authors.forename: Xiangui
authors.initials: X
authors.lastname: He
authors.affiliation: Chinese Medicine Hospital of Zhejiang Province, Hangzhou, Zhejiang 310006, China.
authors.forename: Ergang
authors.initials: E
authors.lastname: Du
authors.affiliation: Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
authors.forename: Kelimu
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
authors.forename: Bilian
authors.initials: B
authors.lastname: Ke