title: Evaluation of the Glasgow Prognostic Score in patients receiving chemoradiotherapy for stage III and IV esophageal cancer.
abstract: High Glasgow Prognostic scores (GPSs) have been associated with poor outcomes in various tumors, but the values of GPS and modified GPS (mGPS) in patients with advanced esophageal cancer receiving chemoradiotherapy (CRT) has not yet been reported. We have evaluated these with respect to predicting responsiveness to CRT and long-term survival. Between January 2002 and December 2011, tumor responses in 142 esophageal cancer patients (131 men and 11 women) with stage III (A, B and C) and IV receiving CRT were assessed. We assessed the value of the GPS as a predictor of a response to definitive CRT and also as a prognostic indicator in patients with esophageal cancer receiving CRT. We found that independent predictors of CRT responsiveness were Eastern Cooperative Oncology Group (ECOG) performance status, GPS and cTNM stage. Independent prognostic factors were ECOG performance status and GPS for progression-free survival and ECOG performance status, GPS and cTNM stage IV for disease-specific survival. GPS may be a novel predictor of CRT responsiveness and a prognostic indicator for progression-free and disease-specific survival in patients with advanced esophageal cancer. However, a multicenter study as same regime with large number of patients will be needed to confirm these outcomes.
authors.affiliation: Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kimura
authors.affiliation: Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Kunisaki
authors.affiliation: Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Makino
authors.affiliation: Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oshima
authors.affiliation: Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ota
authors.affiliation: Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama-city University, Yokohama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Oba
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama-city University, Yokohama, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Takagawa
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama-city University, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kosaka
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama-city University, Yokohama, Japan.
authors.forename: H A
authors.initials: HA
authors.lastname: Ono
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama-city University, Yokohama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama-city University, Yokohama, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Endo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D059248:Chemoradiotherapy / Q000009:adverse effects / Q000401:mortality; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D034141:Hypoalbuminemia / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D012709:Serum Albumin; D002097:C-Reactive Protein
keywords: Glasgow Prognostic Score; Modified Glasgow Prognostic Score; chemoradiotherapy; esophageal cancer; inflammation-based prognostic score