title: [THE ATOMIC-FORCE MICROSCOPY STUDY OF STRUCTURAL FUNCTIONAL CHARACTERISTICS OF NEUTROPHILS IN PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASES IN PHASE OF EXACERBATION].
abstract: The technique of atomic-force microscopy was applied to analyze the structural functional characteristics (morphology, force of adhesion, rigidity of membrane) of neutrophils in patients with chronic obstructive disease of lungs in phase of exacerbation. The regimen of force spectroscopy was applied to implement quantitative evaluation of module of elasticity (Young module) of cell membrane and force of adhesion of neutrophils. The study established decreasing of size of neutrophils, increasing of granularity of cytoplasm, increasing of Young module and force of adhesion in patients with chronic obstructive disease of lungs in phase of exacerbation.
authors.forename: V V
authors.initials: VV
authors.lastname: Gainitdinova
authors.forename: L A
authors.initials: LA
authors.lastname: Sharafutdinova
authors.forename: I M
authors.initials: IM
authors.lastname: Kamaltdinov
authors.forename: S N
authors.initials: SN
authors.lastname: Avdeev
mesh_terms: D002462:Cell Membrane / Q000648:ultrastructure*; D055119:Elastic Modulus; D005260:Female; D006801:Humans; D008297:Male; D018625:Microscopy, Atomic Force; D008875:Middle Aged; D009504:Neutrophils / Q000648:ultrastructure*; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology*