title: Dengue in China: Comprehensive Phylogenetic Evaluation Reveals Evidence of Endemicity and Complex Genetic Diversity.
abstract: Despite the increasing threat of dengue outbreaks in China, it is still considered as an imported disease and its introduction and/or circulation patterns remain obscure. On the basis of the most extensive phylogenetic analysis to date, we showed highly complex genetic diversity of dengue viruses (DENVs) in south China with up to 20 different clades/lineages from multiple serotypes co-circulating in the same year. Despite that most of these clades/lineages were resulted from imported cases, evidence of local persistence of DENV serotype 1 (DENV-1) was observed, indicating its potential endemicity in Guangdong province. This study, therefore, provided an overview of DENV genetic diversity and evolutionary dynamics in China, which will be useful for developing policies to prevent and control future dengue outbreaks in China.
authors.affiliation: Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas; Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Jiangsu, China ruchen@utmb.edu.
authors.forename: Rubing
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas; Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Jiangsu, China.
authors.forename: Guan-Zhu
authors.initials: GZ
authors.lastname: Han
mesh_terms: D002681:China / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology* / Q000821:virology; D003716:Dengue Virus / Q000145:classification / Q000235:genetics*; D019353:Endemic Diseases; D014644:Genetic Variation; D014943:Global Health; D006801:Humans; D010802:Phylogeny