title: Reactions of isolated persulfides provide insights into the interplay between H2S and persulfide reactivity.
abstract: Hydrogen sulfide is ubiquitous in biological systems and exerts function over a wide range of important physiological processes. Complementing free H2S, the reductant-labile sulfur pool plays significant roles in the translocation and action of sulfide, however the chemistry of reductant-labile sulfide sources has not been studied systematically. Using a combination of NMR and UV-Vis spectroscopy, we investigated the spectroscopic properties and reactivity of three isolated organic persulfides and report a simple model for persulfide reactivity, including their roles as nucleophiles, electrophiles, and sulfide donors.
authors.affiliation: Department of Chemistry and Biochemistry, Institute of Molecular Biology, Materials Science Institute. University of Oregon, Eugene, OR 97403, USA.
authors.forename: T Spencer
authors.initials: TS
authors.lastname: Bailey
authors.affiliation: Department of Chemistry and Biochemistry, Institute of Molecular Biology, Materials Science Institute. University of Oregon, Eugene, OR 97403, USA. Electronic address: pluth@uoregon.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Pluth
mesh_terms: D000818:Animals; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010084:Oxidation-Reduction; D013057:Spectrum Analysis; D013440:Sulfides / Q000737:chemistry*
chemical_list: D013440:Sulfides; C051552:persulfides; D006862:Hydrogen Sulfide
keywords: Hydrogen sulfide; Persulfides; Polysulfides; Redox chemistry; Sulfane sulfur