title: Dynamic assembly of a zinc-templated bifunctional organocatalyst in the presence of water for the asymmetric aldol reaction.
abstract: A bifunctional organocatalytic system consisting of simple pyridine ligands containing separate catalytic functionalities was assembled using ZnCl2. This novel metal-templated catalyst furnished high yields and stereoselectivities towards the aldol reaction. The addition of controlled amounts of water turned out to be crucial to dissolve the system and achieve optimal results.
authors.affiliation: Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry and Molecular Modelling, c/Jordi Girona 18-26, E08034 Barcelona, Spain. ciril.jimeno@iqac.csic.es jordi.sola@iqac.csic.es.
authors.forename: Anna
authors.initials: A
authors.lastname: Serra-Pont
authors.forename: Ignacio
authors.initials: I
authors.lastname: Alfonso
authors.forename: Ciril
authors.initials: C
authors.lastname: Jimeno
authors.forename: Jordi
authors.initials: J
authors.lastname: Solà
mesh_terms: D001592:Benzyl Alcohols / Q000138:chemical synthesis*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry; D008024:Ligands; D008962:Models, Theoretical; D009942:Organometallic Compounds / Q000737:chemistry*; D011392:Proline / Q000031:analogs & derivatives / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D012997:Solvents; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry; D014867:Water / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D001592:Benzyl Alcohols; D002712:Chlorides; D008024:Ligands; D009942:Organometallic Compounds; D011725:Pyridines; D012997:Solvents; D017967:Zinc Compounds; D014867:Water; C016837:zinc chloride; D011392:Proline; D013890:Thiourea; D015032:Zinc