title: Diffuse Infiltrative Gastrointestinal Lipomatosis in a Guinea Pig (Cavia porcellus).
abstract: An intact adult male guinea pig (Cavia porcellus) went into cardiopulmonary arrest during a surgical procedure, and efforts at resuscitation were unsuccessful. Gross examination revealed a gastric rupture along the greater curvature of the stomach, which was associated with free blood and ingesta in the abdominal cavity, and a 2-cm nodular, partially circumferential, soft-to-firm mass within the pyloric region. Histologically, the pyloric mass was composed of sheets of infiltrative adipocytes expanding the muscular wall. Similar infiltrative sheets of adipocytes were present adjacent to the rupture site and within the small intestine, cecum, and colon. These findings are consistent with diffuse infiltrative lipomatosis, an exceedingly rare condition in human and veterinary species. This report is the first description of this rare disease in guinea pigs, and the concurrent involvement of both the stomach and intestines has not been reported in any veterinary species.
authors.affiliation: Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA. jbeninso@med.umich.edu.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Beninson
authors.affiliation: Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Keller
authors.affiliation: Unit for Laboratory Animal Medicine, In Vivo Animal Core, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Hoenerhoff
mesh_terms: D017667:Adipocytes / Q000473:pathology*; D000818:Animals; D001344:Autopsy / Q000662:veterinary; D001706:Biopsy / Q000662:veterinary; D005767:Gastrointestinal Diseases / Q000473:pathology / Q000662:veterinary*; D041981:Gastrointestinal Tract / Q000473:pathology*; D006168:Guinea Pigs; D008068:Lipomatosis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D013275:Stomach Rupture / Q000473:pathology / Q000662:veterinary*