title: Towards integrative systems pharmacology models in oncology drug development.
abstract: Quantitative systems pharmacology (QSP) modeling represents an emerging area of value to further streamline knowledge integration and to better inform decision making processes in drug development. QSP models reside at the interface between systems biology models and pharmacological models, yet their concrete implementation still needs to be established further. This review outlines key modeling techniques in both of these areas and to subsequently discuss challenges and opportunities for further integration, in oncology drug development.
authors.affiliation: Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden, The Netherlands. Electronic address: jgc.vanhasselt@gmail.com.
authors.forename: J G Coen
authors.initials: JG
authors.lastname: van Hasselt
authors.affiliation: Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden, The Netherlands. Electronic address: p.vandergraaf@lacdr.leidenuniv.nl.
authors.forename: Piet H
authors.initials: PH
authors.lastname: van der Graaf
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003657:Decision Making; D015195:Drug Design; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D049490:Systems Biology / Q000379:methods
chemical_list: D000970:Antineoplastic Agents