title: Two-Year Anatomical and Functional Outcomes After Macular Hole Surgery: A Prospective, Controlled Study.
abstract: OBJECTIVE
  To determine 2-year anatomical and functional outcomes after macular hole (MH) surgery.
  
  
  METHODS
  The surgical eye (SE) and fellow eye (FE) of 10 patients undergoing MH surgery were examined preoperatively and at 3, 12, and 24 months postoperatively. Retinal nerve fiber layer (RNFL), external limiting membrane (ELM), inner segment/outer segment (IS/OS) junction, cone outer-segment tips (COST) line, and ganglion cell inner plexiform layer (GCIPL) thickness were analyzed on spectral-domain optical coherence tomography.
  
  
  RESULTS
  Inferior peripapillary RNFL was thinner in the SE at 110 ± 12.2 versus 123 ± 9.82 for FE (P < .05). Defect size in ELM (r = 0.61; P < .001), IS/ OS (r = 0.67; P < .001) junction, and COST (r = .67; P < .001) line correlated with visual recovery. Average GCIPL was thinner in SE compared to FE (P < .05).
  
  
  CONCLUSIONS
  Eyes after MH repair demonstrated inferior RNFL and GCIPL thinning. Defect size in ELM, IS/OS junction, and COST line predicted visual recovery.
authors.forename: Sumeer
authors.initials: S
authors.lastname: Thinda
authors.forename: Rohan J
authors.initials: RJ
authors.lastname: Shah
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000368:Aged; D001485:Basement Membrane / Q000473:pathology; D058450:Endotamponade; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D016684:Prone Position; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology; D012167:Retinal Perforations / Q000473:pathology / Q000601:surgery*; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology; D013459:Sulfur Hexafluoride / Q000008:administration & dosage; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology; D014821:Vitrectomy
chemical_list: D005466:Fluorocarbons; C042852:perflutren; D013459:Sulfur Hexafluoride