title: Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors.
abstract: Acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. Nowadays, other functions of acetylcholinesterase in the organism are considered, for example its role in regulation of apoptosis. Cholinergic nervous system as well as acetylcholinesterase activity is closely related to pathogenesis of Alzheimer disease. The mostly used therapy of Alzheimer disease is based on enhancing cholinergic function using inhibitors of acetylcholinesterase like rivastigmine, donepezil or galantamine. These drugs can influence not only the acetylcholinesterase activity but also other processes in treated organism. The paper is aimed mainly on possibility of increased expression and protein level of acetylcholinesterase caused by the therapy with acetylcholinesterase inhibitors.
authors.affiliation: Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Czech Republic.
authors.forename: Alžběta
authors.initials: A
authors.lastname: Kračmarová
authors.affiliation: Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Drtinová
authors.affiliation: Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defense, Czech Republic. miroslav.pohanka@unob.cz.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Pohanka
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism*; D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D016903:Drug Monitoring / Q000379:methods; D057075:Enzyme Assays; D006801:Humans; D018697:Nootropic Agents / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D002800:Cholinesterase Inhibitors; D018697:Nootropic Agents; D000110:Acetylcholinesterase; D000109:Acetylcholine
keywords: Acetylcholine; Acetylcholinesterase; Alzheimer disease; Inhibition; Neurodegeneration