title: Highly Efficient SiRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems.
abstract: RNA interference (RNAi) mediated by small interfering RNA (SiRNA) has recently emerged as a potent machinery in regulating gene expression at the post-translation step. Despite its efficiency and specificity, the biggest hurdle against its wide application is the safe and effective delivery of the SiRNA cargo into target cells. Here, we describe the highly effective SiRNA delivery mediated by the cationic helical polypeptides and polypeptide-based nanosystems both in vitro and in vivo via oral administration.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, 199 Ren-Ai Rd, Suzhou, Jiangsu, 215123, China. lcyin@suda.edu.cn.
authors.forename: Lichen
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green Street, Urbana, IL, 61801, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Zheng
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green Street, Urbana, IL, 61801, USA. jianjunc@illinois.edu.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001483:Base Sequence; D004337:Drug Carriers / Q000737:chemistry*; D008099:Liver / Q000293:injuries / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000172:deficiency / Q000235:genetics
chemical_list: D004337:Drug Carriers; D010455:Peptides; D034741:RNA, Small Interfering; D014409:Tumor Necrosis Factor-alpha
keywords: Acute hepatic injury; Gene silencing; Helical polypeptide; Oral delivery; SiRNA delivery; Tumor necrosis factor α (TNF-α)