title: Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor.
abstract: The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host-guest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host-guest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule.
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: James J
authors.initials: JJ
authors.lastname: Henkelis
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Anthea K
authors.initials: AK
authors.lastname: Blackburn
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Dale
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Nicolaas A
authors.initials: NA
authors.lastname: Vermeulen
authors.affiliation: Joint Centre of Excellence in Integrated Nano-Systems, King Abdulaziz City for Science and Technology , P.O. Box 6086, Riyadh 11442, Saudi Arabia.
authors.forename: Majed S
authors.initials: MS
authors.lastname: Nassar
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Stoddart
mesh_terms: D000494:Allosteric Regulation; D002412:Cations; D018360:Crystallography, X-Ray; D013058:Mass Spectrometry; D066244:Proton Magnetic Resonance Spectroscopy; D013379:Substrate Specificity
chemical_list: D002412:Cations