title: Flavonoids from the cultured cells of Glycyrrhiza uralensis.
abstract: Two new flavonoids (1 and 2), along with 14 known ones (3-16), were isolated from the cultured cells of Glycyrrhiza uralensis. Most of them were prenylated flavonoids. Their structures were elucidated on the basis of spectroscopic data analysis. All compounds showed non-cytotoxicity against five human tumor cell lines. The results suggest that plant cultured cells can yield the secondary metabolites that have not been found in parent plant.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Beijing 100050 , China.
authors.forename: Ke-Ping
authors.initials: KP
authors.lastname: Feng
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Beijing 100050 , China.|b Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission , Beijing 100050 , China.|c Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
authors.forename: Ri-Dao
authors.initials: RD
authors.lastname: Chen
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Beijing 100050 , China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Beijing 100050 , China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Tao
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Beijing 100050 , China.
authors.forename: Ji-Mei
authors.initials: JM
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Beijing 100050 , China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Beijing 100050 , China.|b Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission , Beijing 100050 , China.|c Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
authors.forename: Jun-Gui
authors.initials: JG
authors.lastname: Dai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029882:Glycyrrhiza uralensis / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids
keywords: Glycyrrhiza uralensis; cultured cells; flavonoids