title: Panuveitis With Exudative Retinal Detachments After Vaccination Against Human Papilloma Virus.
abstract: A 20-year-old white woman presented with bilateral acute visual loss (visual acuity: 20/60), panuveitis, and exudative retinal detachments 3 weeks after a second dose of quadrivalent human papillomavirus (HPV4) vaccine. She was treated with oral prednisolone for 6 weeks and responded rapidly. By week 4, vision had normalized and clinical signs resolved. Uveitis after HPV4 vaccination has been reported in two cases. Although the differential diagnosis includes Harada disease, temporal correlation with HPV4 and definitive response to a short course of treatment implicate the vaccine in this case. Vaccine-induced uveitis is rare and difficult to distinguish from coincidental autoimmune disease.
authors.forename: Kunal K
authors.initials: KK
authors.lastname: Dansingani
authors.forename: Mihoko
authors.initials: M
authors.lastname: Suzuki
authors.forename: Jonathan
authors.initials: J
authors.lastname: Naysan
authors.forename: C Michael
authors.initials: CM
authors.lastname: Samson
authors.forename: Richard F
authors.initials: RF
authors.lastname: Spaide
authors.forename: Yale L
authors.initials: YL
authors.lastname: Fisher
mesh_terms: D000284:Administration, Oral; D002829:Choroid / Q000000981:diagnostic imaging; D005122:Exudates and Transudates; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 / Q000009:adverse effects*; D006801:Humans; D015864:Panuveitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D030361:Papillomavirus Infections / Q000517:prevention & control; D011239:Prednisolone / Q000627:therapeutic use; D012163:Retinal Detachment / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D041623:Tomography, Optical Coherence; D014463:Ultrasonography; D014611:Vaccination / Q000009:adverse effects; D014786:Vision Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014792:Visual Acuity / Q000187:drug effects; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D011239:Prednisolone