title: Effects of Prepartum Dietary Energy Level and Nicotinic Acid Supplementation on Immunological, Hematological and Biochemical Parameters of Periparturient Dairy Cows Differing in Parity.
abstract: The periparturient period is critical according to health, productivity and profitability. As this period is fundamental for the success of the lactation period, the interest in improving periparturient health by dietary supplements increased in recent years. The present study investigated the effects of feeding nicotinic acid (NA) combined with varying dietary energy densities on immunological, hematological and biochemical parameters of periparturient cows differing in parity. Thirty-six multiparous and 20 primiparous dairy cows were enrolled in the study 42 days before expected parturition date until 100 days postpartum with the half of the cows being supplemented with 24 g of NA/d. After parturition a diet with 30% concentrate was fed to all cows which was followed by different concentrate escalation strategies. Dietary NA supplementation was ceased on day 24 postpartum. Dietary NA increased (P = 0.010) serum nicotinamide concentrations (mean of 3.35 ± 1.65 µg/mL), whereas NA could not be detected. Present data emphasize that periparturient cows are faced with major physiological challenges and that both parity-groups have different prerequisites to adapt to those changes irrespective of NA supplementation. The overfeeding of energy to cows which were similar in body condition score had only minor effects on periparturient immune system function and the metabolism of those cows.
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Insitute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany. reka.tienken@fli.bund.de.
authors.forename: Reka
authors.initials: R
authors.lastname: Tienken
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Insitute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany. susanne.kersten@fli.bund.de.
authors.forename: Susanne
authors.initials: S
authors.lastname: Kersten
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Insitute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany. jana.frahm@fli.bund.de.
authors.forename: Jana
authors.initials: J
authors.lastname: Frahm
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Insitute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany. liane.huether@fli.bund.de.
authors.forename: Liane
authors.initials: L
authors.lastname: Hüther
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Insitute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany. ulrich.meyer@fli.bund.de.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Meyer
authors.affiliation: Department of Physiology, University of Veterinary Medicine Hanover, Bischofsholer Damm 15, 30173 Hanover, Germany.
authors.forename: Korinna
authors.initials: K
authors.lastname: Huber
authors.affiliation: Clinic for Cattle, University of Veterinary Medicine Hanover, Bischofsholer Damm 15, 30173 Hanover, Germany. juergen.rehage@tiho-hannover.de.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rehage
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Insitute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany. sven.daenicke@fli.bund.de.
authors.forename: Sven
authors.initials: S
authors.lastname: Dänicke
keywords: CD4; CD8; PBMC; dairy cow; immune system; niacin; periparturient