title: TLR activation and ionizing radiation induce strong immune responses against multiple tumor entities.
abstract: Toll-like receptor (TLR) 7/8 ligands act together with radiotherapy and induce profound systemic antitumor immune reactions coordinated by dendritic cells and executed by natural killer (NK) and cytotoxic T cells. Combining TLR ligands and radiation improves both local and distant tumor control and has been shown to be effective against multiple tumor entities.
authors.affiliation: Department of Gastrointestinal, Thoracic and Vascular Surgery; Medizinische Fakultät Carl Gustav Carus; Technische Universität Dresden ; Dresden, Germany ; CCU Molecular and Radiation Oncology; German Cancer Research Center ; Heidelberg, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schölch
authors.affiliation: Department of Gastroenterology and Hepatology; University Hospital Heidelberg ; Heidelberg, Germany.
authors.forename: Conrad
authors.initials: C
authors.lastname: Rauber
authors.affiliation: Department of Gastrointestinal, Thoracic and Vascular Surgery; Medizinische Fakultät Carl Gustav Carus; Technische Universität Dresden ; Dresden, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Weitz
authors.affiliation: Department of Gastrointestinal, Thoracic and Vascular Surgery; Medizinische Fakultät Carl Gustav Carus; Technische Universität Dresden ; Dresden, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Koch
authors.affiliation: CCU Molecular and Radiation Oncology; German Cancer Research Center ; Heidelberg, Germany ; Department of Radiation Oncology; University Hospital Center ; Heidelberg, Germany.
authors.forename: Peter E
authors.initials: PE
authors.lastname: Huber
keywords: GI tumors; TLR7/8 ligand; Toll-like receptor; colorectal cancer; immunotherapy; pancreatic cancer; radiotherapy