title: 1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex.
abstract: The 1.25 Å resolution H32:R crystal structure of a 20 nt ribonucleotide that binds to the TREX-2 complex with high affinity shows a double-stranded RNA duplex arranged along a crystallographic 31 axis in which the antiparallel chains overlap by 18 nucleotides and are related by a crystallographic twofold axis. The duplex shows C-A, U-U and C-C noncanonical base pairings together with canonical Watson-Crick A-U and G-C pairs and a G-U wobble.
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, England.
authors.forename: Eugene
authors.initials: E
authors.lastname: Valkov
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, England.
authors.forename: Murray
authors.initials: M
authors.lastname: Stewart
mesh_terms: D020029:Base Pairing; D003460:Crystallization; D018360:Crystallography, X-Ray; D005090:Exodeoxyribonucleases / Q000737:chemistry*; D011485:Protein Binding; D012330:RNA, Double-Stranded / Q000737:chemistry*; D012441:Saccharomyces cerevisiae
chemical_list: D012330:RNA, Double-Stranded; D005090:Exodeoxyribonucleases
keywords: RNA; noncanonical base pair