title: Soy protein isolate does not affect ellagitannin bioavailability and urolithin formation when mixed with pomegranate juice in humans.
abstract: We investigated the effect of mixing soy protein isolate and pomegranate juice (PJ) on the bioavailability and metabolism of ellagitannins (ETs) in healthy volunteers. Eighteen healthy volunteers consumed PJ alone or PJ premixed with soy protein isolate (PJSP). The concentration of plasma ellagic acid (EA) and urine urolithins was measured. There was no significant difference in plasma EA over a 6-h period between the two interventions. While the maximum concentration of plasma EA after PJSP consumption was slightly but significantly lower than after PJ consumption, EA remained in the plasma longer with an elimination half-life t1/2E at 1.36±0.59 versus 1.06±0.47h for PJSP and PJ consumption, respectively. Urinary urolithin A, B and C was not significantly different between the two interventions. In conclusion, premixing soy protein isolate and PJ did not affect the bioavailability or the metabolism of pomegranate ETs in healthy volunteers.
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics, United States.
authors.forename: Jieping
authors.initials: J
authors.lastname: Yang
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics, United States.
authors.forename: Rupo
authors.initials: R
authors.lastname: Lee
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics, United States.
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Henning
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics, United States.
authors.forename: Gail
authors.initials: G
authors.lastname: Thames
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Hsu
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics, United States.
authors.forename: Hei
authors.initials: H
authors.lastname: ManLam
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics, United States.
authors.forename: David
authors.initials: D
authors.lastname: Heber
authors.affiliation: Center for Human Nutrition, David Geffen School of Medicine, Department of Microbiology, Immunology and Molecular Genetics, United States. Electronic address: zli@mednet.ucla.edu.
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: Li
mesh_terms: D000328:Adult; D001628:Beverages / Q000032:analysis*; D001682:Biological Availability; D003374:Coumarins / Q000378:metabolism*; D005260:Female; D006801:Humans; D047348:Hydrolyzable Tannins / Q000378:metabolism*; D029561:Lythraceae / Q000378:metabolism*; D008297:Male; D010936:Plant Extracts / Q000378:metabolism; D030262:Soybean Proteins / Q000378:metabolism*; D055815:Young Adult
chemical_list: D003374:Coumarins; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; D030262:Soybean Proteins; C013515:ellagitannin; C000595064:urolithin B; C588364:urolithin C; C026423:3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
keywords: Bioavailability; Ellagic acid; Ellagic acid (PubChem CID: 5281855); Ellagitannin (PubChem CID: 71308261); Food matrix; Polyphenols; Punicalagin (PubChem CID: 16149716); Punicalin (PubChem CID: 5388496); Soy protein; Urolithin A (PubChem CID: 5488186); Urolithins