title: Interfacial Reaction-Driven Formation of Silica Carbonate Biomorphs with Subcellular Topographical Features and Their Biological Activity.
abstract: We report the interfacial reaction-driven formation of micro/nanostructured strontium carbonate (SrCO3) biomorphs with subcellular topographical features on strontium zinc silicate (Sr2ZnSi2O7) biomedical coatings and explore their potential use in bone tissue engineering. The resulting SrCO3 crystals build a well-integrated scaffold surface that not only prevents burst release of ions from the coating but also presents nanotopographical features similar to cellular filopodia. The surface with biomorphic crystals enhances osteoblast adhesion, upregulates the alkaline phosphatase activity, and increases collagen production, highlighting the potential of the silica carbonate biomorphs for tissue regeneration.
authors.affiliation: Research Center for Human Tissues & Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , Shenzhen, Guangdong 518055, China.
authors.forename: Guocheng
authors.initials: G
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, Changzhou University , 213164 Changzhou, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zhao
authors.forename: Marco
authors.initials: M
authors.lastname: Möller
authors.forename: Sergio E
authors.initials: SE
authors.lastname: Moya
mesh_terms: D001842:Bone and Bones / Q000187:drug effects; D002254:Carbonates / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010006:Osteoblasts / Q000187:drug effects; D012822:Silicon Dioxide / Q000737:chemistry; D013324:Strontium / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D023822:Tissue Engineering; D015032:Zinc / Q000737:chemistry
chemical_list: D002254:Carbonates; C054286:strontium carbonate; D012822:Silicon Dioxide; D015032:Zinc; D013324:Strontium
keywords: bone regeneration; osteoblast; reactivity; silica biomorph; strontium carbonate