title: Dark Blood Magnetic Resonance Lymphangiography Using Dual-Agent Relaxivity Contrast (DARC-MRL): A Novel Method Combining Gadolinium and Iron Contrast Agents.
abstract: The objective of this study was to develop and demonstrate a technique to eliminate venous enhancement in contrast-enhanced magnetic resonance lymphangiography through shortening T2(⁎) in the blood pool, thus allowing for a lymphatic-only map. Administration of the blood-pool iron agent ferumoxtyol in addition to intracutaneous gadolinium during contrast-enhanced magnetic resonance lymphangiography allows for suppression of vascular structures to achieve venous-free lymphatic mapping.
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA. Electronic address: jmaki@uw.edu.
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Maki
authors.affiliation: Department of Plastic Surgery, University of Washington, Seattle, WA.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Neligan
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA.
authors.forename: Noah
authors.initials: N
authors.lastname: Briller
authors.affiliation: Department of Radiology, Straub Clinic and Hospital, Honolulu, HI.
authors.forename: Lee M
authors.initials: LM
authors.lastname: Mitsumori
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Wilson
mesh_terms: D001769:Blood / Q000000981:diagnostic imaging; D003287:Contrast Media; D052203:Ferrosoferric Oxide; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008209:Lymphedema / Q000000981:diagnostic imaging*; D008220:Lymphography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA; D052203:Ferrosoferric Oxide