title: Prognostic significance of microRNA-203 in cholangiocarcinoma.
abstract: MircroRNA functions as a tumor suppressor or a promoter in cholangiocarcinoma (CCA). Researchers have found that miR-203 functioned as tumor suppressor in many types of cancer. However, the role of miR-203 that plays in CCA remains to be clarified. We aimed to detect the expression level and the prognostic significance of miR-203 in CCA tissues. qRT-RCR was performed to examine the miR-203 expression levels in CCA tissue specimens and corresponding normal tissues. Our findings suggest that miR-203 expression was an independent poor prognostic factor for CCA patient overall survival. Therefore, miR-203 may serve as a valuable prognostic marker and promising treatment target for CCA.
authors.affiliation: Department of Pathology, Xiangya Basic Medical College, Central South University Changsha 410013, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology, The Second Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Gao
authors.affiliation: Transplantation Center, The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Zufa
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of General Surgery, The Second Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Duan
authors.affiliation: Department of Pathology, The Second Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Daiqiang
authors.initials: D
authors.lastname: Li
authors.affiliation: Transplantation Center, The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Transplantation Center, The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Transplantation Center, The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Liu
authors.affiliation: Transplantation Center, The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Transplantation Center, The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Zhizhao
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Transplantation Center, The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Cheng
mesh_terms: D001650:Bile Duct Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D018281:Cholangiocarcinoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate
chemical_list: C546703:MIRN203 microRNA, human; D035683:MicroRNAs
keywords: cholangiocarcinoma; miR-203; mircroRNA; prognosis