title: [Analysis of clinicopathological features and prognosis between alpha-fetoprotein negative and positive hepatocellular carcinoma patients after R0 radical hepatectomy].
abstract: OBJECTIVE
  To investigate the differences between clinicopathological features and prognosis of alpha-fetoprotein (AFP) negative (AFP < 20 ng/ml) and positive (AFP ≥ 20 ng/ml) hepatocellular carcinoma (HCC) patients.
  
  
  METHODS
  Clinicopathological data of 142 AFP-negative and 109 AFP-positive HCC patients who underwent RO radical hepatectomy in the Cancer Hospital of Chinese Academy of Medical Sciences between January 2006 and December 2011 were retrospectively reviewed and analyzed in this study.
  
  
  RESULTS
  Compared with the AFP-negative patients, a higher female to male sex ratio, the later Barcelona Clinic Liver Cancer ( BCLC) stage, more liver capsule invasion and poorer Edmondson-Steiner grade were in the AFP-positive cases (P < 0.05 for all). Furthermore, the 1-, 3-, and 5- year overall survival rates were 94.4%, 82.4% and 61.0% in the AFP-negative group and 87.2%, 61.1% and 40.2%, respectively, in the AFP-positive group (P < 0.001). The multivariate analysis with Cox's proportional hazards model showed that AFP status, tumor size and Edmondson-Steiner grade are independent risk factors for survival of all the patients (P < 0.05) , and large tumor and Edmondson-Steiner grades III/IV are independent risk factors for worse survival in AFP-negative patients (P < 0.05). However, large tumor diameter was proved to be an independent risk factor leading to poor prognosis of AFP-positive cases (P < 0.05).
  
  
  CONCLUSIONS
  High levels of AFP indicate that the tumors are more malignant and with unfavorable prognosis.
authors.forename: An
authors.initials: A
authors.lastname: Songlin
authors.forename: Rong
authors.initials: R
authors.lastname: Weiqi
authors.forename: Wang
authors.initials: W
authors.lastname: Liming
authors.forename: Wu
authors.initials: W
authors.lastname: Fan
authors.forename: Yu
authors.initials: Y
authors.lastname: Weibo
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Liu
authors.initials: L
authors.lastname: Faqiang
authors.forename: Tian
authors.initials: T
authors.lastname: Fei
authors.forename: Bi
authors.initials: B
authors.lastname: Chao
authors.forename: Wu
authors.initials: W
authors.lastname: Jianxiong
mesh_terms: D044466:Asian People; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000509:alpha-Fetoproteins