title: Histological Changes in Pancreatic Islets of Animals with Experimental Diabetes Caused by Xanthurenic Acid under Condition of Suppression of Its Endogenous Synthesis.
abstract: Long-term administration of pyridoxine to rats kept on a diabetogenic diet stimulating endogenous synthesis of xanthurenic acid resulted in minimal glycemia, less pronounced decrease in insulin content in β-cells, and more intensive excretion of xanthurenic acid with urine. Histological changes were observed in 23% pancreatic islets, whereas in rats not treated with pyridoxine, destruction and necrosis of 40-45% β-cells were found in 38% of studied islets.
authors.affiliation: Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan. meyramow@mail.ru.|E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan. meyramow@mail.ru.
authors.forename: G G
authors.initials: GG
authors.lastname: Meyramov
authors.affiliation: Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.|Institut für Diabetes "Gerhardt Katsch", Karlsburg, Germany.
authors.forename: К-D
authors.initials: КD
authors.lastname: Kohnert
authors.affiliation: Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: А А
authors.initials: АА
authors.lastname: Kikimbaeva
authors.affiliation: Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.|E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: А М
authors.initials: АМ
authors.lastname: Аitkulov
authors.affiliation: Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.|E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: Z T
authors.initials: ZT
authors.lastname: Кystaubaeva
authors.affiliation: E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: G M
authors.initials: GM
authors.lastname: Тykeshanova
authors.affiliation: Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: O-N
authors.initials: ON
authors.lastname: Dupont
authors.affiliation: Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: Е М
authors.initials: ЕМ
authors.lastname: Laryushina
authors.affiliation: Diabetes Research Group E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.|E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: А G
authors.initials: АG
authors.lastname: Меyramova
authors.affiliation: E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: G O
authors.initials: GO
authors.lastname: Zhuzbaeva
authors.affiliation: E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: О L
authors.initials: ОL
authors.lastname: Коvalenko
authors.affiliation: E.A. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan.
authors.forename: A S
authors.initials: AS
authors.lastname: Shaybek
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D005526:Food, Formulated / Q000009:adverse effects; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007150:Immunohistochemistry; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D011736:Pyridoxine / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D017208:Rats, Wistar; D014977:Xanthurenates / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D014977:Xanthurenates; C028330:xanthurenic acid; D011736:Pyridoxine
keywords: Zn 2+ ions; pyridoxine; xanthurenic diabetes; β-cells