title: A systematic review of the oral and craniofacial manifestations of cri du chat syndrome.
abstract: Cri du chat syndrome is an autosomal disorder. Because it affects few people in the population it is considered a rare disease, yet it is one of the most common autosomal chromosomal syndromes in humans. It entails pathognomonic alterations that affect the craniofacial and oral anatomy of patients. The aim of this study is to review these craniofacial and oral abnormalities in patients with Cri du chat syndrome. The PubMed Medline database was searched using two different strategies. First, we used "Dentistry" and "Cri du chat" as keywords; second, we used "Cri du chat" and "craniofacial." Seven articles in which the main orofacial and cranio-skeletal characteristics of patients with Cri du chat syndrome were described were selected according to the inclusion and exclusion criteria. Cri du Chat syndrome entails pathognomonic characteristics in the craniofacial area (epicanthus, short philtrum, and wide nasal bridge), the oral area (mandibular retrognathism and anterior open bite) and the cranial region (alterations at the cranial base angle and a small upper airway). However, more studies on larger samples are needed to specify the orofacial and craniofacial characteristics of patients with Cri du chat syndrome more accurately. Clin. Anat. 29:555-560, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Department of Integrated Dentistry for Adults and Patients with Special Diseases, School of Dentistry, University of Seville, Spain.
authors.forename: José-Ramón
authors.initials: JR
authors.lastname: Corcuera-Flores
authors.affiliation: Department of Integrated Dentistry for Adults and Patients with Special Diseases, School of Dentistry, University of Seville, Spain.
authors.forename: Lizett
authors.initials: L
authors.lastname: Casttellanos-Cosano
authors.affiliation: Department of Oral Surgery, School of Dentistry, University of Seville, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Torres-Lagares
authors.affiliation: Department of Integrated Dentistry for Adults and Patients with Special Diseases, School of Dentistry, University of Seville, Spain.
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: Serrera-Figallo
authors.affiliation: Department of Integrated Dentistry for Adults and Patients with Special Diseases, School of Dentistry, University of Seville, Spain.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Rodríguez-Caballero
authors.affiliation: Department of Integrated Dentistry for Adults and Patients with Special Diseases, School of Dentistry, University of Seville, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Machuca-Portillo
mesh_terms: D019465:Craniofacial Abnormalities / Q000209:etiology; D003410:Cri-du-Chat Syndrome / Q000150:complications / Q000473:pathology*; D006801:Humans; D009055:Mouth / Q000473:pathology*; D012886:Skull / Q000473:pathology*
keywords: craniofacial; cri du chat; dentistry