title: Revisiting the Non-Animal Peroxidase Superfamily.
abstract: Peroxidases reduce peroxide through substrate oxidation in order to alleviate oxidative stress in aerobic organisms. Since the initial description of the non-animal peroxidase superfamily, great effort has been made to characterize this large and heterogeneous group of proteins. Next generation sequencing data have permitted an in-depth study of the molecular evolution of this superfamily and allowed us to perform a phylogenetic reconstruction. Through this analysis, we identified two additional class I members and, here, we discuss the similarities and differences among members of this class. Our results provide new insights into the organization of these antioxidant enzymes, allowing us to propose a new model for the emergence and evolution of this superfamily.
authors.affiliation: Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Lazzarotto
authors.affiliation: Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil.
authors.forename: Andreia Carina
authors.initials: AC
authors.lastname: Turchetto-Zolet
authors.affiliation: Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil. Electronic address: marcia.margis@ufrgs.br.
authors.forename: Márcia
authors.initials: M
authors.lastname: Margis-Pinheiro
mesh_terms: D020418:Algal Proteins / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D001665:Binding Sites; D019143:Evolution, Molecular; D006861:Hydrogen Peroxide / Q000378:metabolism; D010544:Peroxidases / Q000145:classification* / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D010940:Plant Proteins / Q000378:metabolism
chemical_list: D020418:Algal Proteins; D000975:Antioxidants; D010940:Plant Proteins; D006861:Hydrogen Peroxide; D010544:Peroxidases
keywords: antioxidant metabolism; heme peroxidases; molecular evolution