title: Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study.
abstract: BACKGROUND
  Breast cancer (BC) is primarily considered a genetic disorder with a complex interplay of factors including age, gender, ethnicity, family history, personal history and lifestyle with associated hormonal and non-hormonal risk factors. The SNP rs2910164 in miR146a (a G to C polymorphism) was previously associated with increased risk of BC in cases with at least a single copy of the C allele in breast cancer, though results in other cancers and populations have shown significant variation.
  
  
  METHODS
  In this study, we examined this SNP in an Australian sporadic breast cancer population of 160 cases and matched controls, with a replicate population of 403 breast cancer cases using High Resolution Melting.
  
  
  RESULTS
  Our analysis indicated that the rs2910164 polymorphism is associated with breast cancer risk in both primary and replicate populations (p=0.03 and 0.0013, respectively). In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40-2.23).
  
  
  CONCLUSIONS
  The microRNA miR146a has a potential role in the development of breast cancer and the effects of its SNPs require further inquiry to determine the nature of their influence on breast tissue and cancer.
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia; Griffith Health Institute, Griffith University, Queensland, Australia.
authors.forename: Akanksha
authors.initials: A
authors.lastname: Upadhyaya
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia; Griffith Health Institute, Griffith University, Queensland, Australia.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Smith
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia; Griffith Health Institute, Griffith University, Queensland, Australia.
authors.forename: Diego
authors.initials: D
authors.lastname: Chacon-Cortes
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia; Griffith Health Institute, Griffith University, Queensland, Australia.
authors.forename: Gwladys
authors.initials: G
authors.lastname: Revêchon
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.
authors.forename: Claire
authors.initials: C
authors.lastname: Bellis
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.
authors.forename: Rod A
authors.initials: RA
authors.lastname: Lea
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia; Griffith Health Institute, Griffith University, Queensland, Australia.
authors.forename: Larisa M
authors.initials: LM
authors.lastname: Haupt
authors.affiliation: Griffith Health Institute, Griffith University, Queensland, Australia; Cancer Council Queensland, Brisbane, Queensland, Australia; The Prostate Cancer Foundation of Australia, New South Wales, Australia; Health and Wellness Institute, Edith Cowan University, Western Australia, Australia; Centre for Clinical Research, University of Queensland, Queensland, Australia.
authors.forename: Suzanne K
authors.initials: SK
authors.lastname: Chambers
authors.affiliation: Griffith Health Institute, Griffith University, Queensland, Australia; Cancer Council Queensland, Brisbane, Queensland, Australia; School of Public Health, Queensland University of Technology, Queensland, Australia.
authors.forename: Philippa H
authors.initials: PH
authors.lastname: Youl
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia; Griffith Health Institute, Griffith University, Queensland, Australia. Electronic address: lyn.griffiths@qut.edu.au.
authors.forename: Lyn R
authors.initials: LR
authors.lastname: Griffiths
mesh_terms: D000368:Aged; D001315:Australia; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs
keywords: BRCA; Breast cancer; Polymorphism; SNP; miR146a; miRNA