title: Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults.
abstract: Regular exercise improves aging-induced deterioration of arterial stiffness, and is associated with elevated production of pentraxin 3 (PTX3) and anti-inflammatory as well as anti-atherosclerotic effects. However, the time-dependent effect of exercise training on arterial stiffness and PTX3 production remains unclear. The purpose of this study was to investigate the time course of the association between the effects of training on the circulating PTX3 level and arterial stiffness in middle-aged and older adults. Thirty-two healthy Japanese subjects (66.2±1.3 year) were randomly divided into two groups: training (exercise intervention) and sedentary controls. Subjects in the training group completed 8 weeks of aerobic exercise training (60-70% peak oxygen uptake (VO2peak) for 45 min, 3 days per week); during the training period, we evaluated plasma PTX3 concentration and carotid-femoral pulse wave velocity (cfPWV) every 2 wk. cfPWV gradually declined over the 8-week training period, and was significantly reduced after 6 and 8 week of exercise intervention (P<0.05). Plasma PTX3 level was significantly increased after 4 weeks of the intervention (P<0.05). In addition, the exercise training-induced reduction in cfPWV was negatively correlated with the percent change in plasma PTX3 level after 6 week (r=-0.54, P<0.05) and 8 weeks (r=-0.51, P<0.05) of the intervention, but not correlated at 4 weeks. Plasma PTX3 level was elevated at the early stage of the exercise training intervention, and was subsequently associated with training-induced alteration of arterial stiffness in middle-aged and older adults.
authors.affiliation: Faculty of Sport and Health Sciences, Ryutsu Keizai University, Ibaraki, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Zempo-Miyaki
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fujie
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hasegawa
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sanada
authors.affiliation: Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Maeda
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hamaoka
authors.affiliation: Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iemitsu
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D015444:Exercise; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D063177:Pulse Wave Analysis; D057185:Sedentary Behavior; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013997:Time Factors; D015854:Up-Regulation; D059289:Vascular Stiffness; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins