title: Common and distinct modulation of electrophysiological indices of feedback processing by autistic and psychopathic traits.
abstract: Both autism spectrum disorder (ASD) and psychopathy are primarily characterized by social dysfunction; overlapping phenotypic features may reflect altered function in common brain mechanisms. The current study examined the degree to which neural response to social and nonsocial feedback is modulated by autistic versus psychopathic traits in a sample of typically developing adults (N = 31, 11 males, 18-52 years). Event-related potentials were recorded whilst participants completed a behavioral task and received feedback on task performance. Both autistic and psychopathic traits were associated with alterations in the neural correlates of feedback processing. Sensitivity to specific forms of feedback (social, nonsocial, positively valenced, negatively valenced) differed between the two traits. Autistic traits were associated with decreased sensitivity to social feedback. In contrast, the antisocial domain of psychopathic traits was associated with an overall decrease in sensitivity to feedback, and the interpersonal manipulation domain was associated with preserved processing of positively valenced feedback. Results suggest distinct alterations within specific mechanisms of feedback processing may underlie similar difficulties in social behavior.
authors.affiliation: a Yale School of Medicine , Child Study Center , New Haven , CT , USA.
authors.forename: Virginia
authors.initials: V
authors.lastname: Carter Leno
authors.affiliation: a Yale School of Medicine , Child Study Center , New Haven , CT , USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Naples
authors.affiliation: a Yale School of Medicine , Child Study Center , New Haven , CT , USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Cox
authors.affiliation: a Yale School of Medicine , Child Study Center , New Haven , CT , USA.
authors.forename: Helena
authors.initials: H
authors.lastname: Rutherford
authors.affiliation: a Yale School of Medicine , Child Study Center , New Haven , CT , USA.
authors.forename: James C
authors.initials: JC
authors.lastname: McPartland
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000987:Antisocial Personality Disorder / Q000503:physiopathology*; D000067877:Autism Spectrum Disorder / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005246:Feedback; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D012919:Social Behavior; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Autism spectrum disorder; Electroencephalography; Event-related potentials; Feedback processing; Psychopathic traits