title: Transferrin Sialylation in Smoking and Non-Smoking Pregnant Women with Intrauterine Growth Restriction.
abstract: Transferrin (Tf) is a glycosylated protein responsible for transporting iron. Various sialylation levels of Tf are observed during physiological and pathological processes. We studied if the changes in iron stores as well as tobacco smoke may have an impact on foetal development and in consequence lead to intrauterine growth restriction (IUGR). In the third trimester of pregnancy, lower levels of 4-sialoTf isoform and higher levels of 5-sialoTf were observed in the serum of non-smoking women with IUGR in comparison to the control group. On the day of labour, level of 2-sialoTf was significantly lower and level of 3-sialo was Tf higher in the serum of non-smoking women. Level of 4-sialo was found lower in the serum of smoking women with IUGR than in the control group. The observed changes may suggest a connection between iron stores, transport of iron to the foetus and foetal development.
authors.affiliation: a Department of Biomedical and Environmental Analysis , Wrocław Medical University , Wrocław , Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Wrześniak
authors.affiliation: a Department of Biomedical and Environmental Analysis , Wrocław Medical University , Wrocław , Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Kepinska
authors.affiliation: a Department of Biomedical and Environmental Analysis , Wrocław Medical University , Wrocław , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Bizoń
authors.affiliation: b 2nd Department and Clinic of Gynaecology and Obstetrics , Wrocław Medical University , Wrocław , Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Milnerowicz-Nabzdyk
authors.affiliation: a Department of Biomedical and Environmental Analysis , Wrocław Medical University , Wrocław , Poland.
authors.forename: Halina
authors.initials: H
authors.lastname: Milnerowicz
mesh_terms: D000328:Adult; D019075:Electrophoresis, Capillary; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000209:etiology*; D006801:Humans; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012907:Smoking / Q000009:adverse effects*; D014168:Transferrin / Q000378:metabolism*
chemical_list: D014168:Transferrin
keywords: capillary electrophoresis; intrauterine growth restriction; pregnancy; sialylation; tobacco smoke; transferrin