title: Neuroglobin and Nogo-a as biomarkers for the severity and prognosis of traumatic brain injury.
abstract: OBJECTIVE
  To identify the early changes of serum neuroglobin and Nogo-A concentrations and the relations to traumatic brain injury (TBI) severity and prognosis.
  
  
  METHODS
  Serum samples were obtained and analyzed from 34 patients with TBI within the first 96 h after injury. Comparative analysis combined with Glasgow Coma Scale (GCS) scores and the 6-month prognosis of these patients was performed.
  
  
  RESULTS
  Significant correlations were found between peak serum neuroglobin and Nogo-A concentrations and a patient's GCS score on admission (p < 0.001). The mean peak serum neuroglobin and Nogo-A concentrations were both significantly higher in patients with an unfavorable outcome at 6 months after injury (p < 0.05).
  
  
  CONCLUSIONS
  Serum neuroglobin and Nogo-A levels could be suggested as biomarkers for predicting TBI severity and prognosis.
authors.affiliation: a Department of Neurosurgery and.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.affiliation: a Department of Neurosurgery and.
authors.forename: He-Li
authors.initials: HL
authors.lastname: Cao
authors.affiliation: a Department of Neurosurgery and.
authors.forename: Shi-Wen
authors.initials: SW
authors.lastname: Chen
authors.affiliation: a Department of Neurosurgery and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: a Department of Neurosurgery and.
authors.forename: Wen-Wei
authors.initials: WW
authors.lastname: Gao
authors.affiliation: a Department of Neurosurgery and.
authors.forename: Heng-Li
authors.initials: HL
authors.lastname: Tian
authors.affiliation: b Department of Neurology , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , P.R. China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Xue
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis; D005260:Female; D015600:Glasgow Coma Scale; D005914:Globins; D006801:Humans; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000097:blood*; D000078787:Neuroglobin; D000070798:Nogo Proteins; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D009185:Myelin Proteins; D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D000070798:Nogo Proteins; C000603199:RTN4 protein, human; D005914:Globins
keywords: Biomarker; Nogo-A; neuroglobin; prognosis; traumatic brain injury