title: New ribosomes for new memories?
abstract: Widely thought to be a housekeeping process, the regulation and synthesis of rRNA emerges as a potentially central mechanism for the maintenance of synaptic plasticity and memory. We have recently shown that an essential component of late-phase synaptic plasticity is rRNA biosynthesis - the rate-limiting step in the production of new ribosomes. We hypothesize that a particular population of ribosomes is generated upon learning-associated neural activity to alter the rate of synthesis of plasticity factors at tagged synapses that will support the maintenance of synaptic plasticity and memory.
authors.affiliation: Department of Pathology; State University of New York; Downstate Medical Center ; Brooklyn, New York ; The Robert F. Furchgott Center for Neural and Behavioral Science; State University of New York; Downstate Medical Center ; Brooklyn, New York.
authors.forename: A Iván
authors.initials: AI
authors.lastname: Hernández
authors.affiliation: Department of Pathology; State University of New York; Downstate Medical Center ; Brooklyn, New York ; The Robert F. Furchgott Center for Neural and Behavioral Science; State University of New York; Downstate Medical Center ; Brooklyn, New York.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Alarcon
authors.affiliation: Department of Pathology; State University of New York; Downstate Medical Center ; Brooklyn, New York.
authors.forename: Kim D
authors.initials: KD
authors.lastname: Allen