title: Choroid Plexus Tumors: Experience of 10 Cases with Special References to Adult Cases.
abstract: Choroid plexus tumors (CPTs) are rare intraventricular neoplasms accounting for about 0.3-0.6% of all intracranial tumors. This retrospective study on CPTs presents clinico-pathological features and management strategies based on a 20-year single-institutional experience. This series included 10 consecutive patients with pathologically proven CPTs; 5 choroid plexus papillomas (CPPs), 3 atypical CPPs (ACPPs), and 2 choroid plexus carcinomas (CPCs). Their clinical, radiological, and histopathological features as well as management including follow-up studies were reviewed. The patients included five males and five females, aging from 0 years to 61 years with median of 28 years. The affected site was lateral ventricle in two adults and fourth ventricle in eight patients; four children and four adults. The most common symptoms were gait disturbance and memory disturbance. All the patients underwent craniotomy with total, subtotal, and partial removals achieved in 50%, 40%, and 10% of the patients, respectively. The occurrence of the high grade subtypes was 50% in both the adult and pediatric groups. The Ki-67/MIB-1 index increased across the three histological subtypes, from CPP to ACPP and then to CPC. Adjuvant therapy was administered in three patients. The two patients (one adult and one child) with CPC died of whole central nervous system dissemination. At a median of 62-month follow-up, the other eight patients were alive, with only one patient having recurrence and reoperation. The results demonstrate that gross total resection is usually curative for CPP and ACPP, and adjuvant chemoradiotherapy would be required for CPC and incompletely resected ACPP.
authors.affiliation: Department of Neurosurgery, Graduate School of Medical and Dental Sciences.
authors.forename: Manoj
authors.initials: M
authors.lastname: Bohara
authors.forename: Masashi
authors.initials: M
authors.lastname: Hirabaru
authors.forename: Shingo
authors.initials: S
authors.lastname: Fujio
authors.forename: Michiyo
authors.initials: M
authors.lastname: Higashi
authors.forename: Hajime
authors.initials: H
authors.lastname: Yonezawa
authors.forename: Prasanna
authors.initials: P
authors.lastname: Karki
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Hanaya
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hirano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tokimura
authors.forename: Kazunori
authors.initials: K
authors.lastname: Arita
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000601:surgery; D002648:Child; D016545:Choroid Plexus Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D003399:Craniotomy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome