title: Analgesic efficacy of intraperitoneal administration of bupivacaine in cats.
abstract: Objectives The aim of this study was to evaluate the analgesic efficacy of intraperitoneal (IP) bupivacaine in cats undergoing ovariohysterectomy (OVH). Methods Forty-five cats were included in a randomized, prospective, blinded study after owners' written consent was obtained. The anesthetic protocol included acepromazine-buprenorphine-propofol-isoflurane. A ventral midline incision was made and cats (n = 15/group) were administered either IP saline 0.9% (negative and positive control groups; NG and PG, respectively) or IP bupivacaine (2 mg/kg; bupivacaine group; BG). Cats in the PG received meloxicam (0.2 mg/kg SC). An OVH was performed and postoperative pain was evaluated using a dynamic interactive visual analog scale (DIVAS), the UNESP-Botucatu multidimensional composite pain scale (MCPS) and mechanical nociceptive thresholds (MNT) for up to 8 h after the end of surgery. Postoperative sedation was evaluated using DIVAS. Rescue analgesia was provided with buprenorphine and/or meloxicam. Repeated measures linear models and a Cochran-Mantel-Haenszel test were used for statistical analysis ( P <0.05). Results There was a significant effect of treatment on the number of times rescue analgesia was administered ( P = 0.002) (PG, n = 2, 13%; NG, n = 12, 80%; BG, n = 4, 27%) with the number of rescues being higher in the NG group than in the PG ( P = 0.0004) and BG ( P = 0.02) groups. The DIVAS, MCPS and MNT were significantly different when compared with baseline values at different time points; however, data were not significantly different among groups. Conclusions and relevance Treatments PG and BG produced similar analgesia in terms of pain scores, number of times rescue analgesia was administered and MNT. Based on rescue analgesia, IP administration of bupivacaine provides analgesia in cats after OVH.
authors.affiliation: 1 Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada.
authors.forename: Javier
authors.initials: J
authors.lastname: Benito
authors.affiliation: 1 Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Monteiro
authors.affiliation: 1 Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Lavoie
authors.affiliation: 2 Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada.
authors.forename: Guy
authors.initials: G
authors.lastname: Beauchamp
authors.affiliation: 3 Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.|4 Center for Comparative Medicine and Translational Research, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.|5 Center for Pain Research and Innovation, UNC School of Dentistry, Chapel Hill, NC, USA.
authors.forename: B Duncan X
authors.initials: BDX
authors.lastname: Lascelles
authors.affiliation: 1 Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada.
authors.forename: Paulo V
authors.initials: PV
authors.lastname: Steagall
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000758:Anesthesia / Q000662:veterinary; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002047:Buprenorphine / Q000008:administration & dosage*; D002415:Cats / Q000502:physiology / Q000601:surgery*; D005260:Female; D007044:Hysterectomy / Q000662:veterinary; D007274:Injections, Intraperitoneal / Q000662:veterinary; D000077239:Meloxicam; D010052:Ovariectomy / Q000662:veterinary; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary*; D011446:Prospective Studies; D013843:Thiazines / Q000008:administration & dosage*; D013844:Thiazoles / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D002047:Buprenorphine; D000077239:Meloxicam