title: Vitamin D Receptor Genetic Polymorphism Is Significantly Associated with Risk of Type 2 Diabetes Mellitus in Chinese Han Population.
abstract: OBJECTIVE
  We investigated the effect of vitamin D receptor (VDR) gene polymorphism on the risk of type 2 diabetes mellitus (T2DM) in a Chinese Han population.
  
  
  METHODS
  Three tagSNPs (rs11574129, rs2228570 and rs739837) were genotyped using TaqMan assays in a case-control study including 669 cases with T2DM, 1084 individuals with impaired fasting glucose (IFG) and 1,961 controls with normal fasting glucose. Multiple logistic regression was applied to analyze the association of SNPs and the risk of diabetes by adjusting for covariates including age, sex, body mass index (BMI) and smoking. General linear model (GLM) was applied to compare fasting blood glucose levels between genotypes and adjusted for confounding factors.
  
  
  RESULTS
  The results showed that rs739837 was significantly associated with increased risk of T2DM in additive model (OR = 1.166, 95% CI 1.017-1.337, p = 0.028) and dominant (OR = 1.166, 95% CI 1.017-1.337, p = 0.002) model. Stratified analysis showed that rs739837 and rs2228570 were, respectively, correlated with T2DM in females and males. Significant associations were found between three SNPs and T2DM in the population <55 years of age. SNPs (rs739837, rs11574129) showed significant associations with T2DM in the smoking population. Quantitative trait analysis indicated that the CC group of rs2228570 has lower fasting glucose than TT/TC genotype group in controls.
  
  
  CONCLUSIONS
  This study provides further evidence that rs739837 in the VDR gene is associated with increased risk of T2DM in a Chinese Han population.
authors.affiliation: Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Jia
authors.affiliation: Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Keming
authors.initials: K
authors.lastname: Yang
authors.affiliation: Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Mao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China. Electronic address: yiyangzhan@sina.com.
authors.forename: Yiyang
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: sc@njmu.edu.cn.
authors.forename: Chong
authors.initials: C
authors.lastname: Shen
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose / Q000235:genetics; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011236:Prediabetic State / Q000150:complications; D040641:Quantitative Trait Loci; D018167:Receptors, Calcitriol / Q000235:genetics*; D012737:Sex Factors
chemical_list: D001786:Blood Glucose; D018167:Receptors, Calcitriol
keywords: Impaired fasting glucose; Polymorphism; Type 2 diabetes mellitus; Vitamin D receptor