title: Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity.
abstract: A central theme in nervous system function is equilibrium: synaptic strengths wax and wane, neuronal firing rates adjust up and down, and neural circuits balance excitation with inhibition. This push/pull regulatory theme carries through to the molecular level at excitatory synapses, where protein function is controlled through phosphorylation and dephosphorylation by kinases and phosphatases. However, these opposing enzymatic activities are only part of the equation as scaffolding interactions and assembly of multi-protein complexes are further required for efficient, localized synaptic signaling. This review will focus on coordination of postsynaptic serine/threonine kinase and phosphatase signaling by scaffold proteins during synaptic plasticity.
authors.affiliation: From the Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Woolfrey
authors.affiliation: From the Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045 mark.dellacqua@ucdenver.edu.
authors.forename: Mark L
authors.identifier: http://orcid.org/0000-0003-3798-3461
authors.initials: ML
authors.lastname: Dell'Acqua
mesh_terms: D000818:Animals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010766:Phosphorylation / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins; D017346:Protein Serine-Threonine Kinases; D010749:Phosphoprotein Phosphatases
keywords: A-kinase anchoring protein (AKAP); Ca2+/calmodulin-dependent protein kinase II (CaMKII); calcineurin; calcium channel; excitation-transcription coupling; glutamate receptor; phosphoprotein phosphatase 1 (PP1); protein kinase A (PKA); scaffold protein; synaptic plasticity