title: Effects of Cichorium Intybus L. Root Extract on Secretory Activity of the Stomach in Health and Ulcer Disease.
abstract: Gastroprotective effect of Cichorium intybus L. root extract is demonstrated on H. Shay's model of experimental ulcer in rats. The effect is attributed to the antisecretory activity of the plant and stimulation of defense barrier function of the gastric mucosa. The regulatory effect of the phytocomplex on seasonal characteristics of the gastric secretory and defense functions in dogs with Basov's fistula is detected.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. krylova5935@gmail.com.
authors.forename: S G
authors.initials: SG
authors.lastname: Krylova
authors.affiliation: Tomsk National Research State University, Tomsk, Russia.
authors.forename: Z K
authors.initials: ZK
authors.lastname: Vymyatnina
authors.affiliation: Tomsk National Research State University, Tomsk, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Zueva
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Amosova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Razina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Litvinenko
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D018651:Cichorium intybus / Q000737:chemistry*; D004285:Dogs; D015738:Famotidine / Q000494:pharmacology; D005260:Female; D005747:Gastric Fistula; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012621:Seasons; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D015738:Famotidine; D002217:Carbachol
keywords: Cichorium intybus L; gastroprotective effect; secretory activity