title: Cell Models to Study Cell-to-Cell Transmission of α-Synuclein.
abstract: The cell-to-cell transmission of protein aggregates has been implicated in the progression of pathological phenotypes in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. In recent years, several experimental model systems have been developed to study the mechanisms of cell-to-cell transmission. Herein, we describe cell culture models with which cell-to-cell transmission of α-synuclein can be quantitatively analyzed. The principle underlying these models could be applied to developing model systems for transmission of other protein aggregates, such as tau and TDP-43.
authors.affiliation: Neuroscience Research Institute and Department of Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongro-gu, 110-799, South Korea.
authors.forename: Eun-Jin
authors.initials: EJ
authors.lastname: Bae
authors.affiliation: Institute of Biomedical Scienceand Technology, Konkuk University, Seoul, 143-701, South Korea.|Department of Anatomy, Schoolof Medicine, Konkuk University, Seoul, 143-701, South Korea.
authors.forename: He-Jin
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Neuroscience Research Institute and Department of Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongro-gu, 110-799, South Korea. sjlee66@snu.ac.kr.
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics; D018929:Cell Culture Techniques / Q000379:methods*; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D010300:Parkinson Disease / Q000235:genetics; D066263:Protein Aggregation, Pathological / Q000235:genetics*; D051844:alpha-Synuclein / Q000737:chemistry* / Q000235:genetics
chemical_list: D051844:alpha-Synuclein
keywords: Neurodegenerative diseases; Parkinson’s disease; Protein aggregation; Transcellular transmission; α-Synuclein