title: Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade.
abstract: An efficient reaction cascade delivering a series of pyrrolo[1,2-a]quinolines bearing phosphonate or phosphine oxide moieties is presented. This sequence exploits the in situ transformation of propargylic alcohols into transient allenes by means of a strategic [2,3]-sigmatropic rearrangement followed by trapping of the resulting allenes by an adjacent pyrrole ring. Furthermore, the initial small scale batch process was successfully translated into a continuous flow process allowing efficient preparation of selected pyrrolo[1,2-a]quinolines on multigram scale without any safety concerns due to the reaction's inherent exothermic profile.
authors.affiliation: Department of Chemistry, University of Durham , South Road, DH1 3LE, Durham United Kingdom.
authors.forename: Marcus
authors.initials: M
authors.lastname: Baumann
authors.affiliation: Department of Chemistry, University of Durham , South Road, DH1 3LE, Durham United Kingdom.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale