title: Rhodium(III)-Catalyzed Amidation of Unactivated C(sp(3) )-H Bonds.
abstract: Nitrogenation by direct functionalization of C-H bonds represents an important strategy for constructing C-N bonds. Rhodium(III)-catalyzed direct amidation of unactivated C(sp(3) )-H bonds is rare, especially under mild reaction conditions. Herein, a broad scope of C(sp(3) )-H bonds are amidated under rhodium catalysis in high efficiency using 3-substituted 1,4,2-dioxazol-5-ones as the amide source. The protocol broadens the scope of rhodium(III)-catalyzed C(sp(3) )-H activation chemistry, and is applicable to the late-stage functionalization of natural products.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023 (China).
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023 (China).
authors.forename: Guodong
authors.initials: G
authors.lastname: Tang
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023 (China). xwli@dicp.ac.cn.
authors.forename: Xingwei
authors.initials: X
authors.lastname: Li
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000577:Amides; D009942:Organometallic Compounds; D012238:Rhodium
keywords: CH activation; amides; oximes; rhodium; synthetic methods