title: Role of IGF-I signaling in muscle bone interactions.
abstract: Skeletal muscle and bone rely on a number of growth factors to undergo development, modulate growth, and maintain physiological strength. A major player in these actions is insulin-like growth factor I (IGF-I). However, because this growth factor can directly enhance muscle mass and bone density, it alters the state of the musculoskeletal system indirectly through mechanical crosstalk between these two organ systems. Thus, there are clearly synergistic actions of IGF-I that extend beyond the direct activity through its receptor. This review will cover the production and signaling of IGF-I as it pertains to muscle and bone, the chemical and mechanical influences that arise from IGF-I activity, and the potential for therapeutic strategies based on IGF-I. This article is part of a Special Issue entitled "Muscle Bone Interactions".
authors.affiliation: VA Medical Center and University of California San Francisco, San Francisco, CA, USA.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Bikle
authors.affiliation: VA Medical Center and University of California San Francisco, San Francisco, CA, USA.
authors.forename: Candice
authors.initials: C
authors.lastname: Tahimic
authors.affiliation: VA Medical Center and University of California San Francisco, San Francisco, CA, USA.
authors.forename: Wenhan
authors.initials: W
authors.lastname: Chang
authors.affiliation: VA Medical Center and University of California San Francisco, San Francisco, CA, USA.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: National and Kapodistrian University of Athens, Department of Physiology, Medical School, Goudi-Athens, Greece.
authors.forename: Anastassios
authors.initials: A
authors.lastname: Philippou
authors.affiliation: Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA. Electronic address: erbarton@ufl.edu.
authors.forename: Elisabeth R
authors.initials: ER
authors.lastname: Barton
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism; D012038:Regeneration / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: Bone density; Insulin-like growth factor; Muscle hypertrophy; Regeneration; Repair