MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions.
Studies in the cardiovascular research field have demonstrated the vital roles of microRNAs for proper cardiovascular development and functional maintenance. The involvement of aberrant microRNA expression leading to ontogenesis of cardiovascular diseases lends further support of the regulatory role of microRNAs in heart function. Hypoxic insult is one of the major factors that trigger downstream signal cascades which contribute to the pathogenesis of hypoxic/ischemic-related heart diseases. Here, we report the microRNA expression profile in human cardiac-derived cells subjected to 120-h hypoxic treatment. By comparing with the normoxic control state, we identified microRNAs differentially expressed in cardiac cells subjected to hypoxic challenge. MicroRNA microarray data are available at NCBI under the GEO accession number, GSE55387.
Cardiovascular Research Institute, National University Health System, and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Yei-Tsung
YT
Chen
Cardiovascular Research Institute, National University Health System, and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Oi-Wah
OW
Liew
Cardiovascular Research Institute, National University Health System, and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore ; Cardiac Department, National University Health System, Singapore ; Christchurch Heart Institute, University of Otago, Christchurch, New Zealand.
Arthur Mark
AM
Richards
Human cardiac cells; Hypoxic treatment; MicroRNA expression