Comparison of one-stage vs two-stage prosthesis-based breast reconstruction: a systematic review and meta-analysis.
BACKGROUND
The aim of this review is to comprehensively compare the outcomes of one-stage and two-stage prosthesis-based breast reconstruction via meta-analytic methodology.


METHODS
Seventeen studies comparing one-stage and two-stage prosthesis-based breast reconstruction were reviewed. The analysis divided the outcomes into 3 categories: complications, esthetic satisfaction, and total cost for completing reconstruction.


CONCLUSIONS
The one-stage reconstruction group was at significantly higher risk for reconstruction failure and overall complications than the two-stage group. No significant difference was observed between the 2 groups in the results of nipple-sparing mastectomy. The esthetic result analysis demonstrated that both methods showed comparably positive outcomes. The one-stage group incurred lower cost for completing reconstruction than the two-stage group, despite the higher cost for treatment-related complications. Our results suggest that the risks for adverse outcome in patients undergoing one-stage reconstruction may be comparable with that of two-stage reconstruction when performed in patients receiving a nipple-sparing mastectomy. However, further well-controlled studies are required to draw more solid conclusions.
Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, South Korea.
Kyeong-Tae
KT
Lee
Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, South Korea. Electronic address: supramicro@gmail.com.
Goo-Hyun
GH
Mun
D019928:Breast Implantation / Q000009:adverse effects / Q000191:economics / Q000379:methods*; D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D016896:Treatment Outcome
Complication; Implant; One-stage breast reconstruction; Prosthesis-based breast reconstruction; Tissue expander; Two-stage breast reconstruction