First case of infectious endocarditis caused by Parvimonas micra.
P. micra is an anaerobic Gram-positive cocci, and a known commensal organism of the human oral cavity and gastrointestinal tract. Although it has been classically described in association with endodontic disease and peritonsillar infection, recent reports have highlighted the role of P. micra as the primary pathogen in the setting of invasive infections. In its most recent taxonomic classification, P. micra has never been reported causing infectious endocarditis in humans. Here, we describe a 71 year-old man who developed severe native valve endocarditis complicated by aortic valvular destruction and perivalvular abscess, requiring emergent surgical intervention. Molecular sequencing enabled identification of P. micra.
Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Lane Building L 134, Stanford, CA 94305, USA. Electronic address: carlosgomez@stanford.edu.
Carlos A
CA
Gomez
Department of Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Lane Building L 134, Stanford, CA 94305, USA.
Daniel A
DA
Gerber
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA.
Eduardo
E
Zambrano
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA; Clinical Microbiology Laboratory, Stanford Hospital and Clinics, 3375 Hillview Ave, Palo Alto, CA 94304, USA.
Niaz
N
Banaei
Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Lane Building L 134, Stanford, CA 94305, USA.
Stan
S
Deresinski
Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Lane Building L 134, Stanford, CA 94305, USA.
Brian G
BG
Blackburn
D000368:Aged; D004696:Endocarditis / Q000175:diagnosis / Q000382:microbiology*; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D008297:Male; D010462:Peptostreptococcus / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology
16S ribosomal RNA; Gram-positive anaerobic cocci; Infectious endocarditis; Parvimonas micra; Peptostreptococcus