Bioceramic Implant Induces Bone Healing of Cranial Defects.
Autologous bone or inert alloplastic materials used in cranial reconstructions are techniques that are associated with resorption, infection, and implant exposure. As an alternative, a calcium phosphate-based implant was developed and previously shown to potentially stimulate bone growth. We here uncover evidence of induced bone formation in 2 patients. Histological examination 9 months postoperatively showed multinuclear cells in the central defect zone and bone ingrowth in the bone-implant border zone. An increased expression of bone-associated markers was detected. The other patient was investigated 50 months postoperatively. Histological examination revealed ceramic materials covered by vascularized compact bone. The bone regenerative effect induced by the implant may potentially improve long-term clinical outcome compared with conventional techniques, which needs to be verified in a clinical study.
Stockholm Craniofacial Centre, Department of Molecular Medicine and Surgery, Plastic Surgery Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Clinical Neuroscience, Neurosurgical Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Biomatcell, Vinn Excellence Centre of Biomaterials and Cell Therapy, University of Gothenburg, Gothenburg, Sweden; and Department of Engineering Sciences, Applied Materials Science Section, Uppsala University, Uppsala, Sweden.
Thomas
T
Engstrand
Stockholm Craniofacial Centre, Department of Molecular Medicine and Surgery, Plastic Surgery Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Clinical Neuroscience, Neurosurgical Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Biomatcell, Vinn Excellence Centre of Biomaterials and Cell Therapy, University of Gothenburg, Gothenburg, Sweden; and Department of Engineering Sciences, Applied Materials Science Section, Uppsala University, Uppsala, Sweden.
Lars
L
Kihlström
Stockholm Craniofacial Centre, Department of Molecular Medicine and Surgery, Plastic Surgery Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Clinical Neuroscience, Neurosurgical Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Biomatcell, Vinn Excellence Centre of Biomaterials and Cell Therapy, University of Gothenburg, Gothenburg, Sweden; and Department of Engineering Sciences, Applied Materials Science Section, Uppsala University, Uppsala, Sweden.
Kalle
K
Lundgren
Stockholm Craniofacial Centre, Department of Molecular Medicine and Surgery, Plastic Surgery Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Clinical Neuroscience, Neurosurgical Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Biomatcell, Vinn Excellence Centre of Biomaterials and Cell Therapy, University of Gothenburg, Gothenburg, Sweden; and Department of Engineering Sciences, Applied Materials Science Section, Uppsala University, Uppsala, Sweden.
Margarita
M
Trobos
Stockholm Craniofacial Centre, Department of Molecular Medicine and Surgery, Plastic Surgery Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Clinical Neuroscience, Neurosurgical Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Biomatcell, Vinn Excellence Centre of Biomaterials and Cell Therapy, University of Gothenburg, Gothenburg, Sweden; and Department of Engineering Sciences, Applied Materials Science Section, Uppsala University, Uppsala, Sweden.
Håkan
H
Engqvist
Stockholm Craniofacial Centre, Department of Molecular Medicine and Surgery, Plastic Surgery Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Clinical Neuroscience, Neurosurgical Section, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Biomatcell, Vinn Excellence Centre of Biomaterials and Cell Therapy, University of Gothenburg, Gothenburg, Sweden; and Department of Engineering Sciences, Applied Materials Science Section, Uppsala University, Uppsala, Sweden.
Peter
P
Thomsen