[INFORMATIVITY ANALYSIS OF IMMUNOLOGIC MARKERS OF SLOWLY PROGRESSIVE AUTOIMMUNE DIABETES IN ADULTS (LADA)].
A survey of 116 patients with slowly progressive autoimmune diabetes of adults. (LADA) substantiates the need to define at least two kinds of antibodies for final verification of the diagnosis. It's been found that GAD ab and/or IA-2A ab are 'the most conclusive. Gender and age-specific rate of antibodies have been defined. In persons under 45 years ICA ab positive titer was detected significantly less frequently than in patients of middle age (45-59 years), a positive titer IA-2A ab detected more often in younger patients than in middle-aged persons. In women, the frequency of a positive titer ICA ab is significantly higher than that of men, but the incidence of positive titer IA-2A ab. is significantly higher in men than in women. The obtained data on the gender and age particularities of antibody in patients with LADA can be used while defining purposeful examination of the patients.
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Tykhonova
D000367:Age Factors; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000276:immunology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000276:immunology; D008297:Male; D008875:Middle Aged; D017027:Protein Tyrosine Phosphatases / Q000276:immunology; D012737:Sex Factors
D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D007328:Insulin; D017027:Protein Tyrosine Phosphatases; D005968:Glutamate Decarboxylase