25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression.
BACKGROUND
There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma. Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer. The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL-8, angiogenic factor, and vitamin D is still at the dawn of research. Hence, we are aiming to establish the predictive power of inflammatory biomarkers, such as IL-8, and metabolic ones, such as vitamin D. These candidate biomarkers are intended to aid classical biomarkers, such as LDH, in the prognosis of cutaneous melanoma.


METHODS
Serum vitamin D and IL-8 were quantified in melanoma patients and in matching healthy controls.


RESULTS
Median serum vitamin D concentrations were significantly lower (p = 0.003) in melanoma patients as compared to healthy control subjects, while around 65% of the investigated patients have proven a severe circulatory deficiency of this vitamin. IL-8 was found increased (p = 0.001) in melanoma patients as compared to controls.


CONCLUSIONS
Upregulation of proangiogenic factors associated with vitamin D deficiency can prove to be potent future biomarkers candidates, enhancing the predictive power of classical LDH.
Nephrology Hospital "Dr. Carol Davila", 4 Calea Grivitei, 010731 Bucharest, Romania.
Corina-Daniela
CD
Ene
SKINMED Clinic, 8 Splaiul Unirii, 040102 Bucharest, Romania.
Amalia-Elena
AE
Anghel
Immunology Department, Victor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania ; Faculty of Biology, University of Bucharest, 91-95 Splaiul Independenţei, 76201 Bucharest, Romania.
Monica
M
Neagu
Department in Dermatology, Infectious and Tropical Diseases "Dr. Victor Babeş" Clinical Hospital-Research, 281 Soseaua Mihai Bravu, 030303 Bucharest, Romania.
Ilinca
I
Nicolae
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002112:Calcifediol / Q000097:blood*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007249:Inflammation; D016209:Interleukin-8 / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008545:Melanoma / Q000097:blood*; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D011379:Prognosis; D012878:Skin Neoplasms / Q000097:blood*; D015854:Up-Regulation; D014808:Vitamin D Deficiency; D055815:Young Adult; D000096142:Cutaneous Malignant Melanoma
D015415:Biomarkers; C508606:CXCL8 protein, human; D016209:Interleukin-8; D007770:L-Lactate Dehydrogenase; D002112:Calcifediol