The spliceosome, a potential Achilles heel of MYC-driven tumors.
Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome - the core splicing machinery - that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors.
Cold Spring Harbor Laboratory, Bungtown Road, Cold Spring Harbor, NY, 11724, USA.
Olga
O
Anczuków
Cold Spring Harbor Laboratory, Bungtown Road, Cold Spring Harbor, NY, 11724, USA. krainer@cshl.edu.
Adrian R
AR
Krainer
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D017381:Spliceosomes
D016271:Proto-Oncogene Proteins c-myc