The influence of zinc on the blood serum of cadmium-treated rats through the rheological properties.
The blood rheological properties serve as an important indicator for the early detection of many diseases. This study aimed to investigate the influence of zinc (Zn) on blood serum of cadmium (Cd) intoxication-treated male rats through the rheological properties. The rheological parameters were measured in serum of control, Cd, and Cd+Zn groups at wide range of shear rates (225-1875 s(-1)). The rat blood serum showed a non-significant change in cadmium-treated rats' %torque and shear stress at the lower shear rates (200-600 s(-1)) while a significant increase was observed at the higher shear rates (650-1875 s(-1)) compared with the control. The rat blood serum viscosity increased significantly in the Cd-treated group at each shear rate compared with the control. The viscosity and shear rate exhibited a non-Newtonian behavior for all groups. The increase in blood serum viscosity in Cd-treated male rats might be attributed to destruction or changes in the non-clotting proteins, and other blood serum components. In Cd+Zn-treated rats, the rat blood serum viscosity values returned nearer to the control values at each shear rate. Our results confirmed that Zn displaced Cd or compete with the binding sites for Cd uptake.
Department of Physics, College of Science, Al Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia. sherifmoussa96@gmail.com.
Sherif Aa
SA
Moussa
Abdulaziz
A
Alaamer
Mohamed A K
MA
Abdelhalim
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001783:Blood Flow Velocity / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects*; D002104:Cadmium / Q000008:administration & dosage*; D002105:Cadmium Poisoning / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D033081:Shear Strength / Q000187:drug effects; D015032:Zinc / Q000008:administration & dosage*
D000975:Antioxidants; D002104:Cadmium; D015032:Zinc