Licensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis.
Food-specific IgE is central to the pathobiology of food allergy, but not sufficient to induce disease. Chen et al. (2015) demonstrate that food-elicited reactions require an immature mast cell that generates IL-9 to induce its own maturation.
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Nora A
NA
Barrett
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: fausten@research.bwh.harvard.edu.
K Frank
KF
Austen
D000818:Animals; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D016906:Interleukin-9 / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology*; D008415:Mastocytosis / Q000276:immunology*
D016906:Interleukin-9; D007073:Immunoglobulin E