Clinical Prognosis in Neonatal Bacterial Meningitis: The Role of Cerebrospinal Fluid Protein.
Neonates are at high risk of meningitis and of resulting neurologic complications. Early recognition of neonates at risk of poor prognosis would be helpful in providing timely management. From January 2008 to June 2014, we enrolled 232 term neonates with bacterial meningitis admitted to 3 neonatology departments in Shanghai, China. The clinical status on the day of discharge from these hospitals or at a postnatal age of 2.5 to 3 months was evaluated using the Glasgow Outcome Scale (GOS). Patients were classified into two outcome groups: good (167 cases, 72.0%, GOS = 5) or poor (65 cases, 28.0%, GOS = 1-4). Neonates with good outcome had less frequent apnea, drowsiness, poor feeding, bulging fontanelle, irritability and more severe jaundice compared to neonates with poor outcome. The good outcome group also had less pneumonia than the poor outcome group. Besides, there were statistically significant differences in hemoglobin, mean platelet volume, platelet distribution width, C-reaction protein, procalcitonin, cerebrospinal fluid (CSF) glucose and CSF protein. Multivariate logistic regression analyses suggested that poor feeding, pneumonia and CSF protein were the predictors of poor outcome. CSF protein content was significantly higher in patients with poor outcome. The best cut-offs for predicting poor outcome were 1,880 mg/L in CSF protein concentration (sensitivity 70.8%, specificity 86.2%). After 2 weeks of treatment, CSF protein remained higher in the poor outcome group. High CSF protein concentration may prognosticate poor outcome in neonates with bacterial meningitis.
Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jintong
J
Tan
Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Juan
J
Kan
Children's Hospital of Shanghai, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Gang
G
Qiu
Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Dongying
D
Zhao
Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Fang
F
Ren
MOE and Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China.
Zhongcheng
Z
Luo
Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; MOE and Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China.
Yongjun
Y
Zhang
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors; D012720:Severity of Illness Index
D000900:Anti-Bacterial Agents; D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins