Increased NHC Cells in the Peritoneal Cavity of Plasmacytoma Susceptible BALB/c Mouse.
BALB/c strain mice are unique in that they develop murine plasmacytoma (MPC) as a consequence of the inflammation induced by pristane oil injection in the peritoneal cavity. In this work the Treg, Th17, B1, B2, and NHC lymphocyte populations from the peritoneal environment of BALB/c, the susceptible strain, and C57BL/6 mice, which do not develop MPC after oil treatment, were studied. Both oil-treated strains showed decreased levels of Th17 lymphocytes, no significant variation in Treg lymphocytes, and a drastic decrease of all B lymphocyte populations. However, only oil-induced BALB/c showed increased levels of natural helper cells (NHC) which could be important in the myeloma induction.
Departamento de Inmunología, Laboratorio de Inmunología Clínica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 Mexico, DF, Mexico.
Berenice
B
Sánchez-González
Departamento de Anatomía Patológica, Laboratorio de Patología Molecular, Instituto Nacional de Pediatría, 04530 Mexico, DF, Mexico.
Francisco Javier
FJ
García-Vázquez
Departamento de Anatomía Patológica, Laboratorio de Patología Molecular, Instituto Nacional de Pediatría, 04530 Mexico, DF, Mexico.
José Eduardo
JE
Farfán-Morales
Departamento de Inmunología, Laboratorio de Inmunología Clínica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 Mexico, DF, Mexico.
Luis Antonio
LA
Jiménez-Zamudio
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D007249:Inflammation; D008214:Lymphocytes / Q000166:cytology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009821:Oils; D010529:Peritoneal Cavity; D010954:Plasmacytoma / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology; D013729:Terpenes / Q000737:chemistry; D058504:Th17 Cells / Q000378:metabolism
D016207:Cytokines; D009821:Oils; D013729:Terpenes; C009042:pristane