Potential role of immunoglobulin replacement therapy on MRI measures in multiple sclerosis: a systematic review.
Multiple sclerosis is a chronic immune-mediated disease of the nervous system. In the early disease course, axonal loss and neurodegeneration occurs that could possibly lead to irreversible neurological impairments. Preventing brain atrophy may have important clinical implications affecting treatment decisions in the future. In recent years, research efforts have directed towards finding agents to modify the disease and reduce brain volume loss. Intravenous immunoglobulin (IVIg) may have some potential roles in this regard.
a Molecular Immunology Research Center, Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.|b MS Research Center, Neuroscience Institute , Tehran University of Medical Sciences , Tehran , Iran.|c Psychiatry and Psychology Research Center , Tehran University of Medical Sciences , Tehran , Iran.
Ameneh
A
Zare-Shahabadi
d Department of Health Management and Economics, School of Public Health , Tehran University of Medical Sciences , Tehran , Iran.|e Knowledge Utilization Research Center , Tehran University of Medical Sciences , Tehran , Iran.
Arash
A
Rashidian
b MS Research Center, Neuroscience Institute , Tehran University of Medical Sciences , Tehran , Iran.
Mohammad Ali
MA
Sahraian
a Molecular Immunology Research Center, Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.|f Universal Scientific Education and Research Network (USERN) , Tehran , Iran.|g Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
Nima
N
Rezaei
D001921:Brain / Q000000981:diagnostic imaging*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011859:Radiography
D016756:Immunoglobulins, Intravenous
IVIG; brain atrophy; efficacy; immunoglobulin replacement therapy; multiple sclerosis