The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000.
OBJECTIVE
Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion.


METHODS
Spironolactone solid dispersions (1:1, 1:2 and 2:1 drug: carrier weight ratio) were prepared by polyethylene glycol (PEG) 6000 as a carrier by hot melt method. The influence of several amounts of Tween 20, 60, and 80 were also studied. The dissolution profile was evaluated by USP Apparatus II.


RESULTS
The results showed that solid dispersions were efficacious to enhance the dissolution rate of Spironolactone in water; and the procedure indicated that there was an increase in dissolution rate for solid dispersions containing the surfactant Tweens. The solid dispersions were evaluated using Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC) studies; and the results showed no complex formation or change in crystal shape of drug.


CONCLUSIONS
It is concluded that solid dispersion technique can be successfully used for improvement of dissolution of Spironolactone.
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. ; Pharmaceutical Sciences Research Centre, Mazandaran University of Medical Sciences, Sari, Iran.
Jafar
J
Akbari
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. ; Pharmaceutical Sciences Research Centre, Mazandaran University of Medical Sciences, Sari, Iran.
Majid
M
Saeedi
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Katayoun
K
Morteza-Semnani
Pharmaceutical Sciences Research Centre, Mazandaran University of Medical Sciences, Sari, Iran.
Hamid Reza
HR
Kelidari
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Farshad
F
Sadegh Moghanlou
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Gity
G
Zareh
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Sohrab
S
Rostamkalaei
Dissolution; PEG 6000; Solid dispersion; Spironolactone; Tweens