Contributions of Biomolecular NMR to Allosteric Drug Discovery.
Drug discovery is a complex process, and a variety of technologies contribute to its success. Biophysical methods have gained widespread attention within the last decade, and in particular NMR spectroscopy as the most versatile biophysical method has seen numerous applications and significant impact to drug discovery. Here we summarize the potential of NMR to support drug discovery, and highlight a number of recent applications.
Novartis Institutes for Biomedical Research, Novartis Campus, CH-4002 Basel, Switzerland.
Lukasz
L
Skora
Novartis Institutes for Biomedical Research, Novartis Campus, CH-4002 Basel, Switzerland. wolfgang.jahnke@novartis.com.
Wolfgang
W
Jahnke
D000818:Animals; D001703:Biophysics; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular