Programmable Downregulation of Enzyme Activity Using a Fever and NIR-Responsive Molecularly Imprinted Nanocomposite.
A fever and NIR-responsive molecularly imprinted nanocomposite is designed for programmable downregulation of enzyme activity. The target enzyme can be captured specifically and its activity can be downregulated only when body temperature increases abnormally. Upon NIR irradiation, the temperature of the destination region can increase accordingly inducing a further decrease in the enzyme activity.
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.|University of Chinese Academy of Sciences, Beijing, 100039, China.
Zhijun
Z
Zhang
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.|University of Chinese Academy of Sciences, Beijing, 100039, China.
Zhenzhen
Z
Wang
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.|University of Chinese Academy of Sciences, Beijing, 100039, China.
Faming
F
Wang
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Jinsong
J
Ren
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Xiaogang
X
Qu
D015536:Down-Regulation; D005334:Fever / Q000473:pathology*; D057446:Hydrodynamics; D006868:Hydrolysis; D054802:Molecular Imprinting / Q000379:methods*; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D013050:Spectrometry, Fluorescence; D019265:Spectroscopy, Near-Infrared; D013696:Temperature; D014357:Trypsin / Q000378:metabolism*
D014357:Trypsin
NIR-responsive; enzyme activity regulation; molecular imprinting; photothermal; trypsin, nanocomposites