A novel isocoumarin with anti-influenza virus activity from Strobilanthes cusia.
Strobilanthes A (1), a novel isocoumarin with an unusual tetrahydro-4H-pyran-4-one moiety fused isocoumarin core skeleton, together with a known compound (2) was isolated from Strobilanthes cusia. Its chemical structures were elucidated by 2D NMR spectroscopy, mass spectrometry and single-crystal X-ray diffraction analysis. The biosynthetic pathway of 1 could be supposed to be originally derived from 3-methylisocoumarin, a product of AA-MA pathway. Both of two compounds displayed anti-influenza virus activity in vitro.
The Key Laboratory of Chemistry fro Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, People's Republic of China.
Wei
W
Gu
School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, Shandong, People's Republic of China.
Wei
W
Wang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
Xiao-Nian
XN
Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
Yu
Y
Zhang
The Key Laboratory of Chemistry fro Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, People's Republic of China.
Li-Ping
LP
Wang
The Key Laboratory of Chemistry fro Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, People's Republic of China.
Chun-Mao
CM
Yuan
The Key Laboratory of Chemistry fro Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, People's Republic of China.
Lie-Jun
LJ
Huang
The Key Laboratory of Chemistry fro Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China. Electronic address: haoxj@mail.kib.ac.cn.
Xiao-Jiang
XJ
Hao
D027901:Acanthaceae / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification; D049934:Isocoumarins / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects*; D018517:Plant Roots / Q000737:chemistry; D014961:X-Ray Diffraction
D000998:Antiviral Agents; D049934:Isocoumarins; C000606485:strobilanthes A
Anti-influenza virus activity; Novel isocoumarin; Strobilanthes cusia; Unprecedented skeleton