The La-Related Proteins, a Family with Connections to Cancer.
The evolutionarily-conserved La-related protein (LARP) family currently comprises Genuine La, LARP1, LARP1b, LARP4, LARP4b, LARP6 and LARP7. Emerging evidence suggests each LARP has a distinct role in transcription and/or mRNA translation that is attributable to subtle sequence variations within their La modules and specific C-terminal domains. As emerging research uncovers the function of each LARP, it is evident that La, LARP1, LARP6, LARP7 and possibly LARP4a and 4b are dysregulated in cancer. Of these, LARP1 is the first to be demonstrated to drive oncogenesis. Here, we review the role of each LARP and the evidence linking it to malignancy. We discuss a future strategy of targeting members of this protein family as cancer therapy.
Ovarian Cancer Research Centre, Institute for Reproductive and Developmental Biology, Imperial College, Du Cane Road, London W12 0HS, UK. chara.stavraka09@imperial.ac.uk.
Chara
C
Stavraka
Ovarian Cancer Research Centre, Institute for Reproductive and Developmental Biology, Imperial College, Du Cane Road, London W12 0HS, UK. sarah.blagden@oncology.ox.ac.uk.|Department of Oncology, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LE, UK. sarah.blagden@oncology.ox.ac.uk.
Sarah
S
Blagden
D000818:Animals; D001324:Autoantigens / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D005810:Multigene Family; D009369:Neoplasms / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000097585:SS-B Antigen
D001324:Autoantigens; D012261:Ribonucleoproteins; D000097585:SS-B Antigen
LARP; LARP1; RBP; RNA-binding; SS-B; cancer; mRNA; proliferation; transcription; translation