Three new alkaloids and three new phenolic glycosides from Liparis odorata.
Three new alkaloids, liparis alkaloid A (1), B (2), C (3), and three new phenolic glycosides, liparis glycoside H (4), I (5), J (6), together with three known phenolic glycosides (7-9) were isolated from the whole plant of Liparis odorata. Their structures were characterized on the basis of extensive 1D-, 2D-NMR and HR-ESI-MS experiments. In addition, compounds 1-3 revealed hypolipidemic effects in the in vitro bioassays, and the ability to inhibit LPS-induced NO production of these isolated phenolic glycosides (4-9) was also evaluated.
Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Road, Nanchang 330004, Jiangxi, PR China.
Piao
P
Jiang
Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Road, Nanchang 330004, Jiangxi, PR China; Technology Center, Jiangzhong Group, 618 Huoju Road, Nanchang 330096, Jiangxi, PR China.
Hongdong
H
Liu
Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Road, Nanchang 330004, Jiangxi, PR China.
Xianghong
X
Xu
Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Road, Nanchang 330004, Jiangxi, PR China.
Bo
B
Liu
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
Dongming
D
Zhang
Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Road, Nanchang 330004, Jiangxi, PR China.
Xuewen
X
Lai
Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Road, Nanchang 330004, Jiangxi, PR China.
Genghua
G
Zhu
Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Road, Nanchang 330004, Jiangxi, PR China.
Peng
P
Xu
Pharmacy College, Jiangxi University of Traditional Chinese Medicine, 818 Xinwan Road, Nanchang 330004, Jiangxi, PR China. Electronic address: lbin@jzjt.com.
Bin
B
Li
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D056945:Hep G2 Cells; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D029595:Orchidaceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification
D000470:Alkaloids; D006027:Glycosides; D000960:Hypolipidemic Agents; D010636:Phenols; D009569:Nitric Oxide
Alkaloids; Hypolipidemic effect; Liparis odorata; NO production inhibitory activities; Orchid family; Phenolic glycosides