Retinal and optic nerve changes in glaucoma: From animal study to clinical implication.
Animal models of experimental glaucoma provide the ability to longitudinally characterize changes in the optic nerve head and surrounding retinal nerve fiber layer with various imaging modalities and compare them to histomorphometric changes. Analysis of the optic nerve head surface by confocal scanning laser tomography and structures deep to this by spectral domain optical coherence tomography allow for the detection of the earliest structural changes seen in glaucoma. Algorithms utilizing these parameters along with retinal nerve fiber layer measurement are likely to play an important role in the future of glaucoma progression monitoring.
NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Shenton S L
SS
Chew
Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, NSW, Australia; Sydney Eye Hospital, Sydney, NSW, Australia.
Alessandra
A
Martins
NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, NSW, Australia; Singapore Eye Research Institute, Singapore, Singapore. Electronic address: nick.strouthidis@moorfields.nhs.uk.
Nicholas
N
Strouthidis
D000818:Animals; D004195:Disease Models, Animal; D005901:Glaucoma / Q000473:pathology*; D006801:Humans; D018613:Microscopy, Confocal; D009900:Optic Nerve / Q000473:pathology*; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence
Confocal scanning laser tomography; Experimental glaucoma; Optical coherence tomography