Genome-wide mRNA and miRNA expression data analysis to screen for markers involved in sarcomagenesis in human chondrosarcoma cell lines.
Genes and miRNAs involved in sarcomagenesis related pathways are unknown and therefore signaling events leading to mesenchymal cell transformation to sarcoma are poorly elucidated. Exiqon and Illumina microarray study on human chondrosarcoma JJ012 and chondrocytes C28 cell lines to compare and analyze the differentially expressed miRNAs and their gene targets was recently published in the Journal Tumor Biology in 2014. Here we describe in details the contents and quality controls for the miRNA and gene expression data associated with the study that is relevant to this dataset.
Biostatistics and Bioinformatics Core/Division of Bioinformatics, Sylvester comprehensive Cancer Center, University of Miami, 1550 NW 10th Ave, Fox 304A, Miami, FL 33136, USA.
Biju
B
Issac
Department of Orthopaedic Surgery, Miller School of Medicine, University of Miami, 1600 NW 10th Ave, S 8012, Miami, FL 33136, USA.
Karina
K
Galoian
Children's Hospital of Philadelphia, Center of Applied Genomics, 3615 Civic center Blvd, Philadelphia, PA 19104-4318, USA.
Toumy
T
Guettouche
Oncogenomics Core, Sylvester Comprehensive Cancer Center, University of Miami, 1501 NW 10th Ave, BRB 542 B.02, Miami FL 33136, USA.
Loida
L
Navarro
Department of Orthopaedic Surgery and University of Miami Tissue Bank Division, Miller School of Medicine, University of Miami, 1400 NW 12th Ave, UMH, East Bldg 4036, Miami, FL 33136, USA.
H Thomas
HT
Temple
Bioinformatics; Human chrondrosarcoma; Microarray; PCA, principal component analysis; SD, standard deviation; mRNA expression; miRNAs