Current natural products with antihypertensive activity.
Natural products have been an important source of new drugs, which also played a dominant role in the discovery and research of new drugs for the treatment of hypertension. This review article reviews the recent progress in the research and development of natural lead compounds with antihypertensive activity, including alkaloids, diterpenes, coumarins, flavonoids, and peptides. We summarized their structures, sources, as well as the antihypertensive mechanisms. These information provides instructive reference for the following structural modifications and optimization.
School of Medicine, Emory University, Atlanta 30322, GA, USA; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Ren-Ren
RR
Bai
Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: xmwu@cpu.edu.cn.
Xiao-Ming
XM
Wu
Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: jinyixu@china.com.
Jin-Yi
JY
Xu
D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D019684:Magnoliopsida / Q000737:chemistry*; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use; D064209:Phytochemicals / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use
D000959:Antihypertensive Agents; D001688:Biological Products; D010455:Peptides; D064209:Phytochemicals; D010936:Plant Extracts
Action mechanism; Antihypertensive activity; Lead compounds; Natural products