Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by Schwartz's reagent.
Protection and deprotection strategies involving the N-acetyl group are widely utilized in nucleoside and nucleotide chemistry. Herein, we present a mild and selective N-deacetylation methodology, applicable to purine and pyrimidine nucleosides, by means of Schwartz's reagent, compatible with most of the common protecting groups used in nucleoside chemistry.
a School of Pharmacy and Pharmaceutical Sciences , Cardiff , Cardiff University , UK.
Valentina
V
Ferrari
a School of Pharmacy and Pharmaceutical Sciences , Cardiff , Cardiff University , UK.
Michaela
M
Serpi
a School of Pharmacy and Pharmaceutical Sciences , Cardiff , Cardiff University , UK.
Christopher
C
McGuigan
a School of Pharmacy and Pharmaceutical Sciences , Cardiff , Cardiff University , UK.
Fabrizio
F
Pertusati
D000107:Acetylation; D000577:Amides / Q000737:chemistry; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry
D000577:Amides; D009705:Nucleosides; D009711:Nucleotides; D009942:Organometallic Compounds; D010756:Phosphoric Acids; C532427:Schwartz reagent; C011067:phosphoramidic acid
Chemoselective; N-deacetylation; Schwartz reagent; nucleoside; prodrugs; protecting groups