Emergence of a Pseudorabies virus variant with increased virulence to piglets.
Pseudorabies virus (PRV) causes Pseudorabies (PR), an economically important disease in domestic swine. PR outbreaks on pig farms caused by PRV variant strains in Bartha-K61-vaccinated pigs have resulted in considerable economic losses in China since 2011. In this study, the pathogenicity of the PRV variant JS-2012 strain to pigs was investigated by experimentally inoculating piglets of different ages in comparison with a classic virulent PRV SC strain. The JS-2012 strain caused an earlier onset of clinical signs and higher mortality in 15, 30, and 60-day-old pigs, as compared with a classic virulent PRV SC strain. The Bartha-K61 vaccination provided complete protection against challenge with classical virulent PRV, but only partial protection against challenge with the JS-2012 strain in piglets. In conclusion, the increased virulence of the PRV variant may have partly contributed to the PR outbreak in China.
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China.
Wu
W
Tong
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Fei
F
Liu
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China.
Hao
H
Zheng
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Chao
C
Liang
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Yan-jun
YJ
Zhou
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Yi-feng
YF
Jiang
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Tong-ling
TL
Shan
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Fei
F
Gao
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China. Electronic address: guoxinli@shvri.ac.cn.
Guo-xin
GX
Li
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China. Electronic address: gztong@shvri.ac.cn.
Guang-zhi
GZ
Tong
D000367:Age Factors; D000818:Animals; D000829:Animals, Domestic; D000831:Animals, Newborn; D002681:China / Q000453:epidemiology; D002522:Chlorocebus aethiops; D004196:Disease Outbreaks; D004306:Dose-Response Relationship, Immunologic; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D011557:Pseudorabies / Q000473:pathology / Q000517:prevention & control / Q000821:virology*; D022421:Pseudorabies Vaccines / Q000276:immunology*; D013552:Swine; D013553:Swine Diseases / Q000473:pathology / Q000517:prevention & control / Q000821:virology*; D014611:Vaccination / Q000662:veterinary; D014709:Vero Cells; D014774:Virulence
D022421:Pseudorabies Vaccines
Pathogenicity; Pseudorabies virus; Variant