Complement pathway biomarkers and age-related macular degeneration.
In the age-related macular degeneration (AMD) 'inflammation model', local inflammation plus complement activation contributes to the pathogenesis and progression of the disease. Multiple genetic associations have now been established correlating the risk of development or progression of AMD. Stratifying patients by their AMD genetic profile may facilitate future AMD therapeutic trials resulting in meaningful clinical trial end points with smaller sample sizes and study duration.
Royal Eye Unit, Kingston Hospital NHS Foundation Trust, Kingston Upon Thames, UK.
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M
Gemenetzi
Southampton Eye Unit, Southampton University Hospital, Southampton, UK.|Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
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AJ
Lotery
D015415:Biomarkers / Q000378:metabolism*; D003167:Complement Activation; D003165:Complement System Proteins / Q000378:metabolism*; D057092:Geographic Atrophy / Q000378:metabolism*; D006801:Humans; D057135:Wet Macular Degeneration / Q000378:metabolism*
D015415:Biomarkers; D003165:Complement System Proteins