Patterns of Allergic Sensitization in High IgE Syndromes.
Dramatic elevations in the serum IgE level are seen both in polygenic allergic diseases such as atopic dermatitis and food allergy, and in a growing list of monogenic primary immune deficiencies (PIDs). Although the IgE produced in patients with PID has generally been considered to be driven by dysregulated IL-4 production and thus lack antigen specificity, in fact allergen-specific IgE can be detected by skin and serum testing in many of these patients. However, perhaps not surprisingly given the distinct immunologic pathways involved, the patterns of allergic disease and atopic sensitization vary widely between syndromes, leading to strikingly different clinical phenotypes.
University of Virginia Asthma and Allergic Diseases Center, PO Box 801355, Charlottesville, VA, 22908, USA. ml4nz@virginia.edu.
Monica G
MG
Lawrence
D000818:Animals; D003876:Dermatitis, Atopic / Q000276:immunology*; D004485:Eczema / Q000276:immunology*; D005512:Food Hypersensitivity / Q000276:immunology*; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D009154:Mutation
C516591:DOCK8 protein, human; D020662:Guanine Nucleotide Exchange Factors; D007073:Immunoglobulin E
Allergy; IgE; Primary immunodeficiency; Specific IgE