Potential involvement of NET polymorphism in serotonin/norepinephrine reuptake inhibitor response in panic disorder.
BACKGROUND
This is a pilot study assessing the impact of polymorphisms of serotonin transporter (5-HTT; 5-HTTLPR (S/L)) and norepinephrine transporter (NET; rs2242446 (T/C)) genes on selective serotonin reuptake inhibitors (SSRIs) and serotonin/norepinephrine reuptake inhibitors (SNRIs) response in Korean panic disorder (PD) patients.


METHODS
PD patients were treated with SSRI (n = 18) or SNRI (n = 6) for 4 weeks. Panic Disorder Severity Scale (PDSS) was rated to evaluate the treatment response. Wilcoxon signed-rank test was used to compare PDSS scores before and after medication (SSRI or SNRI) as well as to compare those according to genotypes. Mann-Whitney U test was used to compare those between the two groups (SSRI or SNRI).


RESULTS
Both SSRI and SNRI treatments for 4 weeks significantly reduced PDSS scores. We assessed the impact of rs2242446 on this effect of SSRI and SNRI. The scores were significantly decreased after 4 weeks in the SSRI-treated group regardless of genotypes of rs2242446, whereas they were significantly decreased in the SNRI-treated group with only non-C carrier (TT) of rs2242446. On 5-HTTLPR we could not analyse because 22 patients had SS genotype.


CONCLUSIONS
These results suggest that NET polymorphism may affect the SNRI response in Korean PD patients.
a Kohwang Medical Research Institute, School of Medicine, Kyung Hee University , Seoul , Republic of Korea.
Hae Jeong
HJ
Park
a Kohwang Medical Research Institute, School of Medicine, Kyung Hee University , Seoul , Republic of Korea.
Su Kang
SK
Kim
b Department of Psychiatry , School of Medicine, Kyung Hee University , Seoul , Republic of Korea.
Won Sub
WS
Kang
b Department of Psychiatry , School of Medicine, Kyung Hee University , Seoul , Republic of Korea.
Young Jong
YJ
Kim
b Department of Psychiatry , School of Medicine, Kyung Hee University , Seoul , Republic of Korea.
Ah Rang
AR
Cho
b Department of Psychiatry , School of Medicine, Kyung Hee University , Seoul , Republic of Korea.
Jin Kyung
JK
Park
D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics*; D016584:Panic Disorder / Q000188:drug therapy / Q000235:genetics*; D010597:Pharmacogenetics; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D050484:Norepinephrine Plasma Membrane Transport Proteins; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors
Norepinephrine transporter; panic disorder; selective serotonin reuptake inhibitor; serotonin transporter; serotonin/norepinephrine reuptake inhibitor