False positive diagnosis on (131)iodine whole-body scintigraphy of differentiated thyroid cancers.
(131)Iodine is used both to ablate any residual thyroid tissue or metastatic disease and to obtain whole-body diagnostic images after total thyroidectomy for differentiated thyroid cancer (DTC). Even though whole-body scan is highly accurate in showing thyroid residues as well as metastases of DTC, false positive results can be found, possibly leading to diagnostic errors and unnecessary treatments. This paper reviews the physiological and pathological processes involved as well as the strategy to recognize and rule out false positive radioiodine images.
Interdisciplinary Department of Medicine. Endocrinology and Metabolic Diseases, University of Bari, Bari, Italy. vincenzo.triggiani@uniba.it.
Vincenzo
V
Triggiani
Interdisciplinary Department of Medicine. Endocrinology and Metabolic Diseases, University of Bari, Bari, Italy.
Vito Angelo
VA
Giagulli
Endocrinology and Metabolic Diseases, Eboli Hospital, Eboli, Salerno, Italy.
Michele
M
Iovino
Oncology Unit, University of Bari, Bari, Italy.
Giovanni
G
De Pergola
Interdisciplinary Department of Medicine. Endocrinology and Metabolic Diseases, University of Bari, Bari, Italy.
Brunella
B
Licchelli
Nuclear Medicine, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Antonio
A
Varraso
Nuclear Medicine, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Franca
F
Dicembrino
Nuclear Medicine, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Guido
G
Valle
Interdisciplinary Department of Medicine. Endocrinology and Metabolic Diseases, University of Bari, Bari, Italy.
Edoardo
E
Guastamacchia
D005189:False Positive Reactions; D006801:Humans; D007457:Iodine Radioisotopes; D011877:Radionuclide Imaging / Q000379:methods*; D013961:Thyroid Gland / Q000000981:diagnostic imaging*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*; D051598:Whole Body Imaging / Q000379:methods*
D007457:Iodine Radioisotopes
131Iodine; Differentiated thyroid cancer; Metastatic thyroid cancer; Natrium/iodide symporter; Radioiodine uptake; Thyroid scintigraphy; Whole-body scintigraphy