Efficacy of Olyset® Duo, a permethrin and pyriproxyfen mixture net against wild pyrethroid-resistant Anopheles gambiae s.s. from Côte d'Ivoire: an experimental hut trial.
Pyrethroid resistance in malaria vectors has spread across sub-Saharan Africa. Alternative tools and molecules are urgently needed for effective vector control. One of the most promising strategies to prevent or delay the development of resistance is to use at least two molecules having unrelated modes of action in combination in the same bed net. We evaluated in experimental huts in Côte d'Ivoire, a new polyethylene long-lasting insecticidal net (LN) product, Olyset® Duo, incorporating permethrin (PER) and pyriproxyfen (PPF), an insect growth regulator (IGR). PPF alone or in combination with permethrin had a significant impact on fertility (7-12% reduction relative to control) and no effect on fecundity of wild multi-resistant An. gambiae s.s. These results triggered crucial research questions on the behaviour of targeted mosquitoes around the LN. To maximize the sterilizing effect of PPF in the combination, there would be a need for a trade-off between the necessary contact time of the insect with PPF and the surface content of the pyrethroid insecticide that is bioavailable and induces excito-repellency.
Institut Pierre Richet (IPR), Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Alphonsine A
AA
Koffi
Institut Pierre Richet (IPR), Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Ludovic P
LP
Ahoua Alou
Institut de Recherche pour le Développement (IRD), Maladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UM-CNRS 5290 IRD 224, Cotonou, Benin - Faculté des Sciences et Techniques-Université d'Abomey-Calavi, Cotonou, Benin - Centre de Recherche Entomologique de Cotonou (CREC), Cotonou, Benin.
Armel
A
Djenontin
Institut Pierre Richet (IPR), Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Jean-Paul K
JP
Kabran
Institut Pierre Richet (IPR), Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Youssouf
Y
Dosso
Institut Pierre Richet (IPR), Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Aboubacar
A
Kone
IRD MIVEGEC, UM-CNRS 5290 IRD 224, Montpellier, France.
Nicolas
N
Moiroux
Institut de Recherche pour le Développement (IRD), Maladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UM-CNRS 5290 IRD 224, Cotonou, Benin - Centre de Recherche Entomologique de Cotonou (CREC), Cotonou, Benin.
Cedric
C
Pennetier
D000818:Animals; D000852:Anopheles / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D052284:Clutch Size / Q000187:drug effects; D007560:Cote d'Ivoire; D004357:Drug Synergism; D004868:Equipment Failure; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D006798:Housing; D019476:Insect Proteins / Q000235:genetics; D007303:Insect Vectors / Q000187:drug effects* / Q000502:physiology; D007305:Insecticide Resistance; D057148:Insecticide-Treated Bednets; D008288:Malaria / Q000517:prevention & control*; D009032:Mosquito Control / Q000295:instrumentation*; D026023:Permethrin / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D061566:Voltage-Gated Sodium Channels / Q000235:genetics
D019476:Insect Proteins; D011725:Pyridines; D061566:Voltage-Gated Sodium Channels; C055613:pyriproxyfen; D026023:Permethrin