Tracking of Drug Release and Material Fate for Naturally Derived Omega-3 Fatty Acid Biomaterials.
In vitro and in vivo studies were conducted on omega-3 fatty acid-derived biomaterials to determine their utility as an implantable material for adhesion prevention following soft tissue hernia repair and as a means to allow for the local delivery of antimicrobial or antibiofilm agents. Naturally derived biomaterials offer several advantages over synthetic materials in the field of medical device development. These advantages include enhanced biocompatibility, elimination of risks posed by the presence of toxic catalysts and chemical crosslinking agents, and derivation from renewable resources. Omega-3 fatty acids are readily available from fish and plant sources and can be used to create implantable biomaterials either as a stand-alone device or as a device coating that can be utilized in local drug delivery applications. In-depth characterization of material erosion degradation over time using non-destructive imaging and chemical characterization techniques provided mechanistic insight into material structure: function relationship. This in turn guided rational tailoring of the material based on varying fatty acid composition to control material residence time and hence drug release. These studies demonstrate the utility of omega-3 fatty acid derived biomaterials as an absorbable material for soft tissue hernia repair and drug delivery applications.
Department of Research and Development, MAQUET Vascular Systems (formally Atrium Medical Corporation), 40 Continental Blvd, Merrimack, NH, 03054, USA. keith.faucher@maquet.com.
Keith M
KM
Faucher
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. nartzi@mit.edu.|Department of Anesthesiology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 02115, USA. nartzi@mit.edu.
Natalie
N
Artzi
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|ORT Braude College, 21982, Karmiel, Israel.
Moshe
M
Beck
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|ORT Braude College, 21982, Karmiel, Israel.
Rita
R
Beckerman
Department of Research and Development, MAQUET Vascular Systems (formally Atrium Medical Corporation), 40 Continental Blvd, Merrimack, NH, 03054, USA.
Geoff
G
Moodie
Department of Research and Development, MAQUET Vascular Systems (formally Atrium Medical Corporation), 40 Continental Blvd, Merrimack, NH, 03054, USA.
Theresa
T
Albergo
Department of Research and Development, MAQUET Vascular Systems (formally Atrium Medical Corporation), 40 Continental Blvd, Merrimack, NH, 03054, USA.
Suzanne
S
Conroy
Department of Research and Development, MAQUET Vascular Systems (formally Atrium Medical Corporation), 40 Continental Blvd, Merrimack, NH, 03054, USA.
Alicia
A
Dale
Department of Research and Development, MAQUET Vascular Systems (formally Atrium Medical Corporation), 40 Continental Blvd, Merrimack, NH, 03054, USA.
Scott
S
Corbeil
Department of Research and Development, MAQUET Vascular Systems (formally Atrium Medical Corporation), 40 Continental Blvd, Merrimack, NH, 03054, USA.
Paul
P
Martakos
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Cardiovascular Division, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Elazer R
ER
Edelman
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000737:chemistry / Q000493:pharmacokinetics; D005260:Female; D051379:Mice; D008819:Mice, Nude; D011817:Rabbits
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D015525:Fatty Acids, Omega-3
Biomaterials; Fish oil; Fluorescence; IVIS; In vivo material tracking; Omega-3 fatty acids