Efficacy of nanocrystalline bone substitute biphasic calcium phosphate/poly-DL-lactide-co-glycolide for periodontal intrabony defects filling.
OBJECTIVE
Different bone substitutes have been used for filling and reparation of intrabony defects. The aim of this study was to compare nanocrystalline material, biphasic calcium phosphate poly-DL-lactide-co-glycolide (BCP/PLGA) with deproteinised bovine bone (DPBB) and beta-tricalcium phosphate (P-TCP) in the treatment of periodontal intrabony defects.


METHODS
The study included 24 patients with bilateral, intrabony defects in the region of the upper first and second premolar, and the upper first molar. On one side of the mouth, DPBB (BioOss) was used to fill defects in upper premolars while P-TCP (RTR) was used for the upper first molar. BCP/PLGA was applied into periodontal defects of the upper premolars and upper first molar of the opposite side.


RESULTS
The comparison of the BCP/PLGA and the P-TCP group, 6 months following filling of defects, showed a statistically significant reduction of periodontal pocket depth (PPD) and the position of the cement-enamel junction (CEJ) in the group with BCP/PLGA, when compared to the beta-TCP group. The reduction of PPD and CEJ was similar in the groups treated with BCP/PLGA and DPBB.


CONCLUSIONS
Significant reductions of PPD and CEJ were registered in the group with BCP/PLGA when compared to the beta-TCP group.
Momir
M
Stevanović
Vladimir
V
Biočanin
Milica
M
Nedkić
Nenad
N
Ignjatović
D000293:Adolescent; D000328:Adult; D018786:Bone Substitutes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006882:Hydroxyapatites / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000473:pathology* / Q000601:surgery*; D011091:Polyesters / Q000627:therapeutic use*; D055815:Young Adult
D018786:Bone Substitutes; D006882:Hydroxyapatites; D011091:Polyesters; C074950:hydroxyapatite-beta tricalcium phosphate; C033616:poly(lactide)