Effects of a high milk intake during the pre-weaning period on nutrient metabolism and growth rate in Japanese Black cattle.
This study aimed to determine the effects of feeding an increased volume of high-fat milk during the early post-natal life on metabolite concentrations in the blood, the expression of key genes regulating intermediary metabolism in the skeletal muscles, and the rate of growth of Japanese Black cattle. All calves were fed a high-fat milk replacer (crude protein, 26%; crude fat, 25.5%; total dissolved nitrogen, 116%). Control calves (n = 4) were nursed with 500 g milk replacer until 3 months of age, whereas calves in the experimental group (n = 4) were nursed with 1800 g milk replacer until 3 months, and then the volume was gradually reduced until 5 months. Body weight was significantly higher in the experimental group than in the control group at 7 months. Plasma glucose concentrations were significantly lower in the experimental group. Expression of glucose-transporter-4 messenger RNA (mRNA) was lower, whereas that of glucose transporter 1, cluster of differentiation 36, and carnitine palmitoyltransferase-1b mRNA was significantly higher in the Longissimus thoracis of the experimental group. Nutritional status during early post-natal life appears to strongly influence the growth rate and glucose and lipid metabolism in Japanese Black cattle.
Kuju Agricultural Research Center, Kyushu University, Oita, Japan.
Atsuko
A
Matsubara
Kuju Agricultural Research Center, Kyushu University, Oita, Japan.
Hideyuki
H
Takahashi
Zenrakuren, Minato, Tokyo, Japan.
Akira
A
Saito
Kuju Agricultural Research Center, Kyushu University, Oita, Japan.
Aoi
A
Nomura
Kuju Agricultural Research Center, Kyushu University, Oita, Japan.
Khounsaknalath
K
Sithyphone
Growth Physiology Group, AgResearch Ltd., Hamilton, New Zealand.
Christopher D
CD
Mcmahon
Kuju Agricultural Research Center, Kyushu University, Oita, Japan.
Ryoichi
R
Fujino
Kuju Agricultural Research Center, Kyushu University, Oita, Japan.
Yuji
Y
Shiotsuka
Kuju Agricultural Research Center, Kyushu University, Oita, Japan.
Tetsuji
T
Etoh
Kuju Agricultural Research Center, Kyushu University, Oita, Japan.
Mitsuhiro
M
Furuse
Kuju Agricultural Research Center, Kyushu University, Oita, Japan.
Takafumi
T
Gotoh
D000824:Animal Nutritional Physiological Phenomena / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development* / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002334:Carnitine O-Palmitoyltransferase / Q000235:genetics / Q000378:metabolism; D002417:Cattle / Q000254:growth & development* / Q000502:physiology; D004041:Dietary Fats / Q000032:analysis; D004435:Eating / Q000502:physiology*; D015870:Gene Expression; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D008892:Milk / Q000737:chemistry; D018482:Muscle, Skeletal / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D014886:Weaning
D001786:Blood Glucose; D004041:Dietary Fats; D051246:Glucose Transport Proteins, Facilitative; D012333:RNA, Messenger; C542591:CPT1B protein, human; D002334:Carnitine O-Palmitoyltransferase
Japanese Black Cattle; glucose metabolism; high-volume milk replacer; lipid metabolism