Mammary analog secretory carcinoma of the parotid gland: A case report and literature review.
BACKGROUND
Mammary analog secretory carcinoma (MASC) was first described in 2010 by Skálová et al. This entity shares morphologic and immunohistochemical features with the secretory carcinoma (SC) of the breast. MASC usually presents as an asymptomatic mass in the parotid gland and predominantly affects men. This tumor is considered a low-grade carcinoma but has the potential for high-grade transformation. We report one MASC case and a review of world literature.


METHODS
A 66-year-old male patient presented because he noticed a mass of approximately 3×3cm on the right pre-auricular region. Physical examination demonstrated a 3×3.5cm, firm, fixed, non-tender mass in the right pre-auricular region. An MRI of the head and neck showed an ovoid heterogeneous lesion, dependent of the right parotid gland of 27×28mm. We performed a superficial parotidectomy with identification and preservation of the facial nerve. The immunophenotype was positive for epithelial membrane antigen (EMA), CK8/18, vimentin, S-100 protein, and mammoglobin. No further surgical interventions or adjuvant therapies were needed. The patient will have a close follow up.


CONCLUSIONS
The presence of t(12;15) (p13;q25) translocation which results in the ETV6-NTRK3 gene fusion or positive immunochemical studies for STAT5, mammoglobin and S100 protein, are necessary to confirm the diagnosis of MASC. MASC treatment should mimic the management of other low-grade malignant salivary gland neoplasms. The inhibition of ETV6-NTRK3 gene fusion could be used as treatment in the future.
General Surgery Resident, Hospital Ángeles Lomas, Av. Vialidad de la Barranca s/n, Col. Valle de las Palmas Huixquilucan, Estado de México C.P. 52763, Mexico. Electronic address: balanza.ricardo@gmail.com.
Ricardo
R
Balanzá
Department of Surgery, Centro Médico ABC, Av. Carlos Graef Fernández 154, Col. Tlaxala, Del. Cuajimalpa de Morelos, México Distrito Federal C.P. 05300, Mexico. Electronic address: rodrigo.arrangoiz@gmail.com.
Rodrigo
R
Arrangoiz
Department of Surgery, Centro Médico ABC, Av. Carlos Graef Fernández 154, Col. Tlaxala, Del. Cuajimalpa de Morelos, México Distrito Federal C.P. 05300, Mexico.
Fernando
F
Cordera
Department of Surgery, Centro Médico ABC, Av. Carlos Graef Fernández 154, Col. Tlaxala, Del. Cuajimalpa de Morelos, México Distrito Federal C.P. 05300, Mexico.
Manuel
M
Muñoz
Department of Surgery, Centro Médico ABC, Av. Carlos Graef Fernández 154, Col. Tlaxala, Del. Cuajimalpa de Morelos, México Distrito Federal C.P. 05300, Mexico.
Enrique
E
Luque-de-León
Department of Surgery, Centro Médico ABC, Av. Carlos Graef Fernández 154, Col. Tlaxala, Del. Cuajimalpa de Morelos, México Distrito Federal C.P. 05300, Mexico.
Eduardo
E
Moreno
Department of Surgery, Centro Médico ABC, Av. Carlos Graef Fernández 154, Col. Tlaxala, Del. Cuajimalpa de Morelos, México Distrito Federal C.P. 05300, Mexico.
Carlos
C
Toledo
Department of Surgery, Centro Médico ABC, Av. Carlos Graef Fernández 154, Col. Tlaxala, Del. Cuajimalpa de Morelos, México Distrito Federal C.P. 05300, Mexico.
Edgar
E
González