Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester on Nephrotoxicity Caused by Dichlorvos in Rats.
The protective effects of Caffeic Acid Phenethyl Ester (CAPE) and intralipid (IL) on nephrotoxicity caused by acute Dichlorvos (D) toxicity were investigated in this study. Forty-eight Wistar Albino rats were divided into 7 groups as follows: Control, D, CAPE, intralipid, D + CAPE, D + IL, and D + CAPE + IL. When compared to D group, the oxidative stress index (OSI) values were significantly lower in Control, CAPE, and D + IL + CAPE groups. When compared to D + IL + CAPE group, the TOS and OSI values were significantly higher in D group (P < 0.05). When mitotic cell counts were assessed in the renal tissues, it was found that mitotic cell count was significantly higher in the D group while it was lower in the D + CAPE, D + IL, and D + IL + CAPE groups when compared to the control group (P < 0.05). Also, immune reactivity showed increased apoptosis in D group and low profile of apoptosis in the D + CAPE group when compared to the Control group. The apoptosis level was significantly lower in D + IL + CAPE compared to D group (P < 0.05) in the kidneys. As a result, we concluded that Dichlorvos can be used either alone or in combination with CAPE and IL as supportive therapy or as facilitator for the therapeutic effect of the routine treatment in the patients presenting with pesticide poisoning.
Department of Internal Medicine, Medical Faculty, Mustafa Kemal University, 31000 Hatay, Turkey.
Muhammet Murat
MM
Celik
Department of Biochemistry, The Government Hospital of Obstetrics and Gynecology, 31000 Hatay, Turkey.
Ayse
A
Alp
Department of Medical Physiology, Medical Faculty, Mustafa Kemal University, 31000 Hatay, Turkey.
Recep
R
Dokuyucu
Department of Pathology, Medeniyet University Goztepe Training and Research Hospital, 81054 Istanbul, Turkey.
Ebru
E
Zemheri
Department of Pathology, Medeniyet University Goztepe Training and Research Hospital, 81054 Istanbul, Turkey.
Seyma
S
Ozkanli
Department of Internal Medicine, Ministry of Health Batman Regional Government Hospital, 72000 Batman, Turkey.
Filiz
F
Ertekin
Department of Medical Pathology, Medical Faculty, Mustafa Kemal University, 31000 Hatay, Turkey.
Mehmet
M
Yaldiz
Department of Chemistry, Science and Arts Faculty, Mustafa Kemal University, 31000 Hatay, Turkey.
Abdurrahman
A
Akdag
Department of Medical Pathology, Medical Faculty, Mustafa Kemal University, 31000 Hatay, Turkey.
Ozlem
O
Ipci
Department of Medical Pathology, Medical Faculty, Mustafa Kemal University, 31000 Hatay, Turkey.
Serhat
S
Toprak