Serum Uric Acid Increases Risk of Cancer Incidence and Mortality: A Systematic Review and Meta-Analysis.
SUA is a potent antioxidant and thus may play a protective role against cancer. Many epidemiological studies have investigated this hypothesis but provided inconsistent and inconclusive findings. We aimed to precisely elucidate the association between SUA levels and cancer by pooling all available publications. Totally, 5 independent studies with 456,053 subjects and 12 with 632,472 subjects were identified after a comprehensive literature screening from PubMed, Embase, and Web of Science. The pooled RRs showed that individuals with high SUA levels were at an increased risk of total cancer incidence (RR = 1.03, 95% CI 1.01-1.05, P = 0.007). Positive association between high SUA levels and total cancer incidence was observed in males but not females (for men: RR = 1.05, 95% CI 1.02-1.08, P = 0.002; for women, RR = 1.01, 95% CI 0.98-1.04, P = 0.512). Besides, high SUA levels were associated with an elevated risk of total cancer mortality (RR = 1.17, 95% CI 1.04-1.32, P = 0.010), particularly in females (RR = 1.25, 95% CI 1.07-1.45, P = 0.004). The study suggests that high SUA levels increase the risk of total cancer incidence and mortality. The data do not support the hypothesis of a protective role of SUA in cancer.
Department of Surgical Oncology, The Eighty-First Hospital of People's Liberation Army, Nanjing 210002, China ; Liver Transplantation Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Shushan
S
Yan
Department of Surgery Emergency, People's Hospital of Rizhao, Rizhao 276800, China.
Pengjun
P
Zhang
Center of Computer Network, People's Hospital of Rizhao, Rizhao 276800, China.
Wei
W
Xu
Department of Cardiology, People's Hospital of Rizhao, Rizhao 276800, China.
Yuqing
Y
Liu
Department of Endocrinology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China.
Bin
B
Wang
Department of Surgical Oncology, The Eighty-First Hospital of People's Liberation Army, Nanjing 210002, China.
Tao
T
Jiang
Department of Surgical Oncology, The Eighty-First Hospital of People's Liberation Army, Nanjing 210002, China.
Changjiang
C
Hua
Department of Surgical Oncology, The Eighty-First Hospital of People's Liberation Army, Nanjing 210002, China.
Xuan
X
Wang
Department of Rheumatism, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Donghua
D
Xu
Liver Transplantation Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Beicheng
B
Sun
D000975:Antioxidants / Q000032:analysis; D003625:Data Collection; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000453:epidemiology* / Q000401:mortality; D012307:Risk Factors; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood*
D000975:Antioxidants; D014527:Uric Acid