Rh-Catalyzed Synthesis of Coumarin Derivatives from Phenolic Acetates and Acrylates via C-H Bond Activation.
An efficient annulation strategy involving the reaction of phenolic acetates with acrylates in the presence of [Rh2(OAc)4] as catalyst and formic acid as reducing agent, leading to the high yield synthesis of coumarin derivatives, has been developed. The addition of NaOAc as a base increased the yield of the products. The reaction is quite successful for both electron-rich as well as electron-deficient phenolic acetates, affording coumarins with excellent regioselectivity, and proceeds via C-H bond activation proven by deuterium incorporation studies.
Chemical Engineering & Process Development Division, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune, Maharashtra, India -411008.
Sunita K
SK
Gadakh
Chemical Engineering & Process Development Division, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune, Maharashtra, India -411008.
Soumen
S
Dey
Chemical Engineering & Process Development Division, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune, Maharashtra, India -411008.
Arumugam
A
Sudalai