NONINVASIVE GRADING OF RADIATION RETINOPATHY: The Use of Optical Coherence Tomography Angiography.
OBJECTIVE
Previous studies have shown that spectral domain optical coherence tomography can diagnose radiation retinopathy (RR) before ophthalmoscopic findings. Recently, optical coherence tomography angiography (OCT-A) has been helpful in seeing vascular findings undetected by spectral domain optical coherence tomography. The authors wish to demonstrate the OCT-A grading at varying levels of RR.


METHODS
The OCT-A, spectral domain optical coherence tomography, and ophthalmoscopic findings on 7 patients from December 2014 to March 2015 with varying levels of RR are demonstrated.


RESULTS
Findings on OCT-A could be demonstrated before spectral domain optical coherence tomography findings. Patients can be graded on a scale of increasing severity from 0 to 5, based on positive or negative clinical findings of RR between OCT-A. Optical coherence tomography increased central macular thickness, optical coherence tomography evident cysts, and ophthalmoscopy (Grade 0: -,-,-,-; Grade 1: +,-,-,-; Grade 2: +,+,-,-; Grade 3: +,+,+,-; Grade 4: ++,+,+,+; Grade 5: unreadable,++,++,+).


CONCLUSIONS
The use of OCT-A allows for earlier detection of RR; thus, existing grading systems should be modified to include OCT-A.
*Mayo Medical School, Rochester, Minnesota; and †Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
Kevin K
KK
Veverka
Jackson E
JE
AbouChehade
Raymond
R
Iezzi
Jose S
JS
Pulido
D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects*; D002830:Choroid Neoplasms / Q000532:radiotherapy; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008545:Melanoma / Q000532:radiotherapy; D008875:Middle Aged; D011832:Radiation Injuries / Q000145:classification* / Q000209:etiology / Q000473:pathology; D012160:Retina / Q000528:radiation effects*; D012164:Retinal Diseases / Q000145:classification* / Q000209:etiology / Q000473:pathology; D041623:Tomography, Optical Coherence
D007457:Iodine Radioisotopes