Propofol promotes spinal cord injury repair by bone marrow mesenchymal stem cell transplantation.
Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the tail vein. Rat spinal cord injury was clearly alleviated; a large number of newborn non-myelinated and myelinated nerve fibers appeared in the spinal cord, the numbers of CM-Dil-labeled bone marrow mesenchymal stem cells and fluorogold-labeled nerve fibers were increased and hindlimb motor function of spinal cord-injured rats was markedly improved. These improvements were more prominent in rats subjected to bone marrow mesenchymal cell transplantation combined with propofol administration than in rats receiving monotherapy. These results indicate that propofol can enhance the therapeutic effects of bone marrow mesenchymal stem cell transplantation on spinal cord injury in rats.
Department of Anesthesiology, Xingtai People's Hospital, Hebei Medical University, Xingtai, Hebei Province, China.
Ya-Jing
YJ
Zhou
Department of Orthopedic Trauma, Xingtai People's Hospital, Hebei Medical University, Xingtai, Hebei Province, China.
Jian-Min
JM
Liu
Department of Anesthesiology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Shu-Ming
SM
Wei
Department of Anesthesiology, Xingtai People's Hospital, Hebei Medical University, Xingtai, Hebei Province, China.
Yun-Hao
YH
Zhang
Department of Anesthesiology, Xingtai People's Hospital, Hebei Medical University, Xingtai, Hebei Province, China.
Zhen-Hua
ZH
Qu
Department of Urinary Surgery, Xingtai People's Hospital, Hebei Medical University, Xingtai, Hebei Province, China.
Shu-Bo
0000-0002-4218-4616
SB
Chen
anesthesia; bone marrow mesenchymal stem cells; nerve regeneration; neural regeneration; neuroprotection; propofol; repair; spinal cord injury; stem cell transplantation