High-hyperopia database, part I: clinical characterisation including morphometric (biometric) differentiation of posterior microphthalmos from nanophthalmos.
PURPOSE To characterise and differentiate posterior microphthalmos (PM) and nanophthalmos (NO) using morphometric parameters.Patients and methodsConsecutive case database of patients with hyperopia >+7.00 D sphere was analysed retrospectively for clinical and biometric characterisation. Thirty-eight consecutive high-hyperopic subjects (75 eyes) with axial lengths <20.5 mm underwent uniform comprehensive ocular evaluation. Twenty-five subjects were diagnosed as PM and 13 as NO based on the horizontal corneal diameter. Parameters analysed included visual acuity, refraction, horizontal corneal diameter, anterior chamber depth, lens thickness, axial length, fundus changes, and associated ocular pathology.


METHODS
ocular biometry difference between PM and NO.


METHODS
differences in associated ocular pathologies between PM and NO.RESULTS Hyperopia ranged from +7 to +17 D and was similar in the two groups. Lens thickness was statistically more in NO than in PM group (4.53±0.75 mm vs 3.82±0.48 mm, P <0.001), whereas anterior chamber depth was more in the PM than in NO group (3.26±0.36 mm, vs 2.59±0.37 mm, P<0.001). NO had higher association with angle-closure glaucoma (66.7% vs 0%) and pigmentary retinopathy (38.5 vs 8.0%) but lesser association with macular folds (0% vs 24%) as compared with PM. NO was associated with poorer visual acuity.CONCLUSION PM and NO have significant differences in lens thickness, anterior chamber depth, prevalence of glaucoma, pigmentary retinopathy, macular pathology, and visual acuity while being similar in hyperopic refraction.
Srimati Kannuri Santhamma Centre for Vitreo- Retinal Diseases, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, India.
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Relhan
Srimati Kannuri Santhamma Centre for Vitreo- Retinal Diseases, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, India.
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Jalali
Kode Venkatadri Chowdary, David Brown Children's Eye Care Centre, L V Prasad Eye Institute, Tadigadapa, Vijayawada, India.
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Pehre
Center for Clinical Epidemiology and Biostatistics, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, India.
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Rao
Srimati Kannuri Santhamma Centre for Vitreo- Retinal Diseases, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, India.
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Manusani
Srimati Kannuri Santhamma Centre for Vitreo- Retinal Diseases, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, India.
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Bodduluri
D000293:Adolescent; D000328:Adult; D000368:Aged; D000867:Anterior Chamber / Q000473:pathology; D058452:Axial Length, Eye / Q000473:pathology; D001699:Biometry; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000473:pathology; D016208:Databases, Factual; D015785:Eye Diseases, Hereditary / Q000175:diagnosis*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis*; D006801:Humans; D006956:Hyperopia / Q000175:diagnosis*; D007223:Infant; D007908:Lens, Crystalline / Q000473:pathology; D008297:Male; D008850:Microphthalmos / Q000175:diagnosis*; D008875:Middle Aged; D012029:Refraction, Ocular / Q000502:physiology; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology