Recurrent hypersomnia: Report of medication-responsive cases.
BACKGROUND
Recurrent hypersomnia (RH) is a rare disorder without established treatment.


METHODS
We report 2 RH medication-responsive cases with typical characteristics of Kleine-Levin syndrome (KLS).


METHODS
A 10 y.o. girl and a 14 y.o. boy presented with sudden sleepiness for 3-9 days (every 2-3 weeks). Physical examination, brain images and blood tests were normal. Polysomnographic findings were heterogenous, including disrupted sleep architecture. MSLTs revealed 2-3 SOREMPs and short sleep latency. Carbamazepine rendered girl׳s sleep normalization, while risperidone normalized boy׳s sleep cycles.


CONCLUSIONS
Facing the absence of clinical trials in RH, reports of responsive cases are the available therapeutic evidence.
Faculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil.
Bruna V
BV
Perin
Faculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil.
Iorrana
I
Rodrigues
Faculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil.
Franciele T B
FT
Giasson
Faculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil.
Matheus
M
Balen
Instituto de Neurologia e Neurocirurgia (INN), R. Uruguai 1555, 5º andar, Centro, CEP, 99010-112 Passo Fundo, RS, Brazil.
Naiana
N
Posenato
Faculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil ; Instituto de Neurologia e Neurocirurgia (INN), R. Uruguai 1555, 5º andar, Centro, CEP, 99010-112 Passo Fundo, RS, Brazil.
Cassiano M
CM
Forcelini
Carbamazepine; Kleine–Levin syndrome; Recurrent hypersomnia; Risperidone; Treatment