Increased mean platelet volume in patients with panic disorder.
OBJECTIVE
The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD).


METHODS
Sixty-one drug-free patients, aged 18-65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age- and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject.


RESULTS
The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI.


CONCLUSIONS
Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.
Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Mehmet Hanifi
MH
Kokacya
Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Umit Sertan
US
Copoglu
Department of Psychiatry, Faculty of Medicine, Kafkas University, Kars, Turkey.
Yüksel
Y
Kivrak
Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Mustafa
M
Ari
Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Musa
M
Sahpolat
Department of Biochemistry, Kadirli State Hospital, Osmaniye, Turkey.
Kemal Türker
KT
Ulutas
anxiety; mean platelet volume; panic disorder