Small airway epithelial-C/EBPβ is increased in patients with advanced COPD.
The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation.
Department of Experimental Medical Science, Lund University, Lund, Sweden.
Michiko
M
Mori
Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden. leif.bjermer@med.lu.se.
Leif
L
Bjermer
Department of Experimental Medical Science, Lund University, Lund, Sweden. jonas.erjefalt@med.lu.se.|Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden. jonas.erjefalt@med.lu.se.
Jonas S
JS
Erjefält
Department of Pathology and Molecular Medicine, McMaster University, MDCL 4084, 1280 Main Street West, Hamilton, ON, L8S 4P1, Canada. stampfli@mcmaster.ca.|Department of Medicine, Firestone Institute of Respiratory Health at St. Joseph's Health Care, Hamilton, ON, Canada. stampfli@mcmaster.ca.
Martin R
MR
Stampfli
Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden. abraham.roos@gmail.com.|Department of Pathology and Molecular Medicine, McMaster University, MDCL 4084, 1280 Main Street West, Hamilton, ON, L8S 4P1, Canada. abraham.roos@gmail.com.
Abraham B
AB
Roos
D000368:Aged; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000737:chemistry* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D015854:Up-Regulation
D022782:CCAAT-Enhancer-Binding Protein-beta; C545012:CEBPB protein, human