Differential ligand-signaling network of CCL19/CCL21-CCR7 system.
Chemokine (C-C motif) receptor 7 (CCR7), a class A subtype G-Protein Coupled Receptor (GPCR), is involved in the migration, activation and survival of multiple cell types including dendritic cells, T cells, eosinophils, B cells, endothelial cells and different cancer cells. Together, CCR7 signaling system has been implicated in diverse biological processes such as lymph node homeostasis, T cell activation, immune tolerance, inflammatory response and cancer metastasis. CCL19 and CCL21, the two well-characterized CCR7 ligands, have been established to be differential in their signaling through CCR7 in multiple cell types. Although the differential ligand signaling through single receptor have been suggested for many receptors including GPCRs, there exists no resource or platform to analyse them globally. Here, first of its kind, we present the cell-type-specific differential signaling network of CCL19/CCL21-CCR7 system for effective visualization and differential analysis of chemokine/GPCR signaling. Database URL: http:// www. netpath. org/ pathways? path_ id= NetPath_ 46.
Computational Biology Group, Cancer Research Program-9, Rajiv Gandhi Centre for Biotechnology, Thycaud, Poojappura, Thiruvanathapuram 690 014, Kerala, India and.
Rajesh
R
Raju
Institute of Bioinformatics, Discoverer, International Technology Park, Bangalore 560 066, Karnataka, India.
Sachin
S
Gadakh
Institute of Bioinformatics, Discoverer, International Technology Park, Bangalore 560 066, Karnataka, India.
Priyanka
P
Gopal
Computational Biology Group, Cancer Research Program-9, Rajiv Gandhi Centre for Biotechnology, Thycaud, Poojappura, Thiruvanathapuram 690 014, Kerala, India and.
Bijesh
B
George
Institute of Bioinformatics, Discoverer, International Technology Park, Bangalore 560 066, Karnataka, India.
Jayshree
J
Advani
Institute of Bioinformatics, Discoverer, International Technology Park, Bangalore 560 066, Karnataka, India.
Sowmya
S
Soman
Institute of Bioinformatics, Discoverer, International Technology Park, Bangalore 560 066, Karnataka, India.
T S K
TS
Prasad
Computational Biology Group, Cancer Research Program-9, Rajiv Gandhi Centre for Biotechnology, Thycaud, Poojappura, Thiruvanathapuram 690 014, Kerala, India and reshmi@rgcb.res.in.
Reshmi
R
Girijadevi
D000818:Animals; D054415:Chemokine CCL19 / Q000378:metabolism*; D054421:Chemokine CCL21 / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D054400:Receptors, CCR7 / Q000378:metabolism*; D015398:Signal Transduction
D054415:Chemokine CCL19; D054421:Chemokine CCL21; D008024:Ligands; D054400:Receptors, CCR7