Effects of administration of a synthetic low molecular weight/low molar substitution hydroxyethyl starch solution in healthy neonatal foals.
This study compared the effects of IV administration of isotonic fluid therapy and colloidal fluid therapy in healthy neonatal foals. Fifteen healthy neonatal foals were used in a randomized blinded prospective clinical study. Foals were randomly assigned to receive a bolus of 20 mL/kg of tetrastarch (TES) or balanced crystalloid solution. Vital parameters, colloid osmotic pressure (COP), and various clinicopathologic variables were assessed prior to infusion and at various time points up to 120 h after infusion. The treatment group (TES) had a significant increase in both COP and percentage increase in COP at 1 and 3 h. The COP was significantly lower than baseline at 3 h in the control group. No significant changes were observed in coagulation parameters in either group. Tetrastarch was effective in increasing COP for 3 h after infusion and had no notable adverse clinical effects in this group of healthy foals. Further studies are warranted regarding optimal dosing and effects in clinically ill foals.
Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Kate L
KL
Hepworth-Warren
Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
David M
DM
Wong
Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Bonnie L
BL
Hay-Kraus
Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Chong
C
Wang
Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Yaxuan
Y
Sun
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003102:Colloids; D004906:Erythrocyte Count / Q000662:veterinary; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006400:Hematocrit / Q000662:veterinary*; D006736:Horses / Q000097:blood*; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D007552:Isotonic Solutions / Q000494:pharmacology; D019344:Lactic Acid / Q000097:blood; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D009997:Osmotic Pressure; D012119:Respiration / Q000187:drug effects
D003102:Colloids; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D019344:Lactic Acid