Outcomes of allogeneic hematopoietic cell transplantation in patients with biphenotypic acute leukemia.
The outcomes of allogeneic hematopoietic cell transplantation (HSCT) in patients with biphenotypic acute leukemia (BAL) remain unclear. We retrospectively analyzed the outcomes of HSCT in BAL patients in Japan in comparison to acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) using the registration data from a nationwide database. The data of 90, 5371, and 3301 patients with BAL, AML, and ALL, respectively, were included in the analysis. The median follow-up period was 1481.5 days (range: 0–5556). The 5-year overall survival (OS) of the BAL, AML, and ALL patients were 39.6, 41.8, and 42.0 %, respectively (BAL vs. AML, P = 0.98 BAL vs. ALL, P = 0.77). A multivariate analysis revealed that, in comparison to BAL, AML with a better-risk karyotype was associated with superior OS. An analysis of the prognostic factors of BAL patients showed that OS was significantly longer in patients who were in their first complete remission in comparison to patients who were not in remission. Our data suggest that HSCT is an effective treatment for BAL patients, regardless of the presence of any known poor prognostic factors other than a non-remission status.
Jinichi
J
Mori
Ken
K
Ishiyama
Takuhiro
T
Yamaguchi
Junji
J
Tanaka
Naoyuki
N
Uchida
Takeshi
T
Kobayashi
Takahiro
T
Fukuda
Heiwa
H
Kanamori
Koichi
K
Miyamura
Satoshi
S
Takahashi
Tetsuya
T
Eto
Makoto
M
Hirokawa
Shinichiro
S
Mori
Tokiko
T
Nagamura
Yoshiko
Y
Atsuta
Akiyoshi
A
Takami
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000639:trends*; D006801:Humans; D015456:Leukemia, Biphenotypic, Acute / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014184:Transplantation, Homologous / Q000639:trends; D016896:Treatment Outcome; D055815:Young Adult