Experimental Neonatal Sepsis Causes Long-Term Cognitive Impairment.
Neonatal sepsis is a major cause of morbidity and mortality in neonatal intensive care units. Treatment with antibiotics reduces mortality and morbidity, but neonatal sepsis remains a serious life-threatening condition. The objective of this study was to evaluate cognitive impairment in adult mice submitted to sepsis in the neonatal period. To this aim, 2-day-old male C57BL/6 mice were submitted to sepsis by injection of 25 μg of LPS. Sixty days after, the learning and memory were evaluated. It was observed that the mice submitted to neonatal sepsis presented impairment of habituation, aversive, and object recognition memories, and had an increase of immobility time in forced swimming test in adulthood. In conclusion, this study shows that the neonatal sepsis causes long-term brain alterations. These alterations can persist to adulthood in an animal model due to a vulnerability of the developing brain.
Research group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Palhoça, SC, Brazil. clarissamc@gmail.com.
Clarissa M
CM
Comim
Research group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Palhoça, SC, Brazil.
Regina M
RM
Bussmann
Research group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Palhoça, SC, Brazil.
Silvia R
SR
Simão
Research group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Palhoça, SC, Brazil.
Letícia
L
Ventura
Research group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Palhoça, SC, Brazil.
Viviane
V
Freiberger
Research group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Palhoça, SC, Brazil.
Janini J
JJ
Patrício
Research group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Palhoça, SC, Brazil.
Daphne
D
Palmas
Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Bruna P
BP
Mendonça
Research group of Experimental Neuropathology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina (UNISUL), Palhoça, SC, Brazil.
Omar J
OJ
Cassol
Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.|Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston (UTHealth) Medical School, Houston, TX, USA.|Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston (UTHealth) Medical School, Houston, TX, USA.|Neuroscience Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA.
João
J
Quevedo
D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning; D060825:Cognitive Dysfunction / Q000209:etiology* / Q000503:physiopathology; D006185:Habituation, Psychophysiologic; D008297:Male; D018782:Maze Learning; D008810:Mice, Inbred C57BL; D000071074:Neonatal Sepsis / Q000150:complications* / Q000503:physiopathology; D013550:Swimming; D013647:Task Performance and Analysis
Behavior; Central nervous system; Mice; Neonatal sepsis