An introduction to MS imaging in drug discovery and development.
A vital process in drug discovery and development is to assess the absorption, distribution, metabolism, excretion and toxicology of potentially therapeutic compounds in the body. The potential utility of MS imaging has been demonstrated in many studies focusing on molecules including peptides, proteins and lipids. However, MS imaging also permits the direct analysis of drugs and drug metabolites in tissue samples without requiring the use of target-specific labels or reagents. Here, a brief technical description of the technique is presented along with examples of its usefulness at different stages of the drug discovery and development process including absorption, distribution, metabolism, excretion and toxicology, and blood-brain barrier drug penetration investigations.
Biomolecular Imaging & Proteomics, National Center for Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Box 591 Biomedical Ctr., SE-75124 Uppsala, Sweden.
Henrik
H
Lodén
Biomolecular Imaging & Proteomics, National Center for Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Box 591 Biomedical Ctr., SE-75124 Uppsala, Sweden.
Mohammadreza
M
Shariatgorji
Biomolecular Imaging & Proteomics, National Center for Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Box 591 Biomedical Ctr., SE-75124 Uppsala, Sweden.
Anna
A
Nilsson
Biomolecular Imaging & Proteomics, National Center for Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Box 591 Biomedical Ctr., SE-75124 Uppsala, Sweden.
Per E
PE
Andrén
D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D055808:Drug Discovery; D006801:Humans; D007668:Kidney / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000378:metabolism; D051381:Rats; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D004364:Pharmaceutical Preparations