Polyphenolic extract from Hibiscus sabdariffa reduces body fat by inhibiting hepatic lipogenesis and preadipocyte adipogenesis.
Diets high in fat lead to excess lipid accumulation in adipose tissue, which is a crucial factor in the development of obesity, hepatitis, and hyperlipidemia. In this study, we investigated the anti-obesity effect of Hibiscus sabdariffa extract (HSE) in vivo. Hamsters fed a high-fat diet (HFD) develop symptoms of obesity, which were determined based on body weight changes and changes in plasma and serum triglycerides, free fatty acid concentrations, total cholesterol levels, LDL-C levels, HDL-C levels, and adipocyte tissue weight. HFD-fed hamsters were used to investigate the effects of HSE on symptoms of obesity such as adipogenesis and fatty liver, loss of blood glucose regulation, and serum ion imbalance. Interestingly, HSE treatment effectively reduced the effects of the HFD in hamsters in a dose-dependent manner. Further, after inducing maturation of preadipocytes, Hibiscus sabdariffa polyphenolic extract (HPE) was shown to suppress the adipogenesis of adipocytes. However, HPE does not affect the viability of preadipocytes. Therefore, both HSE and HPE are effective and viable treatment strategies for preventing the development and treating the symptoms of obesity.
Department of Beauty Science and Graduate Institute of Beauty Science Technology, Chienkuo Technology University, Changhua 500, Taiwan.
Erl-Shyh
ES
Kao
Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan. wcj@csmu.edu.tw.
Mon-Yuan
MY
Yang
Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan. wcj@csmu.edu.tw.
Chia-Hung
CH
Hung
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan and Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Chien-Ning
CN
Huang
Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan. wcj@csmu.edu.tw and Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Chau-Jong
CJ
Wang
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects / Q000502:physiology; D050156:Adipogenesis / Q000187:drug effects*; D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects*; D000818:Animals; D019440:Anti-Obesity Agents; D006224:Cricetinae; D059305:Diet, High-Fat; D005230:Fatty Acids, Nonesterified / Q000097:blood; D031584:Hibiscus / Q000737:chemistry*; D008055:Lipids / Q000032:analysis / Q000097:blood; D050155:Lipogenesis / Q000187:drug effects*; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009765:Obesity / Q000209:etiology / Q000503:physiopathology; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D059808:Polyphenols / Q000008:administration & dosage*
D019440:Anti-Obesity Agents; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010936:Plant Extracts; D059808:Polyphenols