High Sensitivity of Aged Mice to Deoxynivalenol (Vomitoxin)-Induced Anorexia Corresponds to Elevated Proinflammatory Cytokine and Satiety Hormone Responses.
Deoxynivalenol (DON), a trichothecene mycotoxin that commonly contaminates cereal grains, is a public health concern because of its adverse effects on the gastrointestinal and immune systems. The objective of this study was to compare effects of DON on anorectic responses in aged (22 mos) and adult (3 mos) mice. Aged mice showed increased feed refusal with both acute i.p. (1 mg/kg and 5 mg/kg) and dietary (1, 2.5, 10 ppm) DON exposure in comparison to adult mice. In addition to greater suppression of food intake from dietary DON exposure, aged mice also exhibited greater but transient body weight suppression. When aged mice were acutely exposed to 1 mg/kg bw DON i.p., aged mice displayed elevated DON and DON3GlcA tissue levels and delayed clearance in comparison with adult mice. Acute DON exposure also elicited higher proinflammatory cytokine and satiety hormone responses in the plasma of the aged group compared with the adult group. Increased susceptibility to DON-induced anorexia in aged mice relative to adult mice suggests that advanced life stage could be a critical component in accurate human risk assessments for DON and other trichothecenes.
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA. clarke27@anr.msu.edu.|Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA. clarke27@anr.msu.edu.
Erica S
ES
Clark
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA. bflannery27@gmail.com.|Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA. bflannery27@gmail.com.
Brenna M
BM
Flannery
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA. egardner@anr.msu.edu.
Elizabeth M
EM
Gardner
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA. pestka@anr.msu.edu.|Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA. pestka@anr.msu.edu.|Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA. pestka@anr.msu.edu.
James J
JJ
Pestka
D000375:Aging / Q000097:blood / Q000276:immunology*; D000818:Animals; D000855:Anorexia / Q000097:blood / Q000139:chemically induced* / Q000276:immunology; D001835:Body Weight; D002766:Cholecystokinin / Q000097:blood*; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D004435:Eating / Q000187:drug effects; D008297:Male; D008810:Mice, Inbred C57BL; D019894:Peptide YY / Q000097:blood*; D012528:Satiety Response / Q000187:drug effects*; D014018:Tissue Distribution; D014255:Trichothecenes / Q000493:pharmacokinetics / Q000633:toxicity*
D016207:Cytokines; D014255:Trichothecenes; D019894:Peptide YY; D002766:Cholecystokinin; C007262:deoxynivalenol
CCK; IL-1β; IL-6; PYY; aging; anorexia; mouse; mycotoxin; weight loss