Castration-Resistant Prostate Cancer: AUA Guideline Amendment 2015.
OBJECTIVE
The purpose of this amendment is to incorporate relevant newly-published literature to better provide a rational basis for the management of patients with castration-resistant prostate cancer.


METHODS
The original systematic review and meta-analysis of the published literature yielded 303 studies published from 1996 through 2013. This review informed the majority of the guideline statements. Clinical Principles and Expert Opinions were used for guideline statements lacking sufficient evidence. In April 2014, the CRPC guideline underwent amendment based on an additional literature search, which retrieved additional studies published between February 2013 and February 2014. Thirty-seven studies from this search provided data relevant to the specific treatment modalities for CRPC. In March 2015, the CRPC guideline underwent a second amendment, which incorporated 10 additional studies into the evidence base published through February 2015.


RESULTS
Guideline statements based on six index patients developed to represent the most common scenarios encountered in clinical practice were amended appropriately. The additional literature provided the basis for an update of current supporting text as well as the incorporation of new guideline statements for multiple index patients.


CONCLUSIONS
Given the rapidly evolving nature of this field, this guideline should be used in conjunction with recent systematic literature reviews and an understanding of the individual patient's treatment goals. Patients' preferences and personal goals should be considered when choosing management strategies. This guideline will be continually updated as new literature emerges in the field.
American Urological Association Education and Research, Inc., Linthicum, Maryland.
William T
WT
Lowrance
American Urological Association Education and Research, Inc., Linthicum, Maryland.
Bruce J
BJ
Roth
American Urological Association Education and Research, Inc., Linthicum, Maryland.
Erin
E
Kirkby
American Urological Association Education and Research, Inc., Linthicum, Maryland.
Mohammad Hassan
MH
Murad
American Urological Association Education and Research, Inc., Linthicum, Maryland.
Michael S
MS
Cookson
D019468:Disease Management; D006801:Humans; D008297:Male; D057240:Patient Preference; D017410:Practice Guidelines as Topic; D064129:Prostatic Neoplasms, Castration-Resistant / Q000628:therapy*
androgen antagonist; drug therapy; prostatic cancer, castration-resistant