Sustained Neuromuscular Blockade after Vecuronium Use in a Premature Infant.
Background Prolonged use of neuromuscular blocking agents (NMBAs) is very common in critically ill children both in pediatric and neonatal intensive care units. There are no guidelines available for use of NMBAs in children or neonates in the US, and the data for their safety in this age group is limited. Case Description Our case describes prolonged neuromuscular blockade following concurrent use of a NMBA along with aminoglycosides and steroids in the setting of renal failure in a premature infant. Conclusion Prolonged use of NMBAs in preterm infants should be avoided if possible or should be restricted to the shortest possible duration and the smallest possible physiologically effective dose. Concurrent use of NMBAs with aminoglycoside and steroids should be avoided, especially in the setting of renal failure.
Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas.
Mitali
M
Sahni
Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas.
C Joan
CJ
Richardson
Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas.
Sunil K
SK
Jain
aminoglycosides; neonates; neuromuscular block; premature; vecuronium