Electrochemotherapy of a Multirecurrent Dermatofibrosarcoma Protuberans of the Orbital Margin: A Case Report.
Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous sarcoma with high recurrence rate. Radical surgery is the treatment of choice, although in cosmetically-sensitive areas such as the head and neck, this option is often not pursued. Electrochemotherapy (ECT) is a minimal invasive anti-tumor modality which is increasingly being used to treat skin metastases from different malignancies. A 31-year-old woman presented with subcutaneous local multirecurring DFSP located at the proximal end of the left eyebrow. ECT was offered as a palliative treatment to avoid radical disfiguring surgery. Two days following ECT, the patient was discharged in good general health. Partial tumor regression was appreciable at two months' follow-up by ultrasound and magnetic resonance imaging. At six months, residual fibrotic tissue was observed; at three years, no evidence of the tumour was detected. In our case, ECT achieved good local tumor control with excellent cosmetic results, preserving the patient's quality of life.
Department of Plastic and Reconstructive Surgery, San Gallicano, Dermatologic Institute for Research and Care, Rome, Italy bonadies.antonio@gmail.com.
Antonio
A
Bonadies
Radiology and Diagnostic Imaging Unit, San Gallicano Dermatologic Institute for Research and Care, Rome, Italy.
Fulvia
F
Elia
Radiology and Diagnostic Imaging Unit, San Gallicano Dermatologic Institute for Research and Care, Rome, Italy.
Francesco Maria
FM
Solivetti
Radiology and Diagnostic Imaging Unit, Regina Elena Cancer Institute, Rome, Italy.
Antonello
A
Vidiri
Dermatopathological Laboratory, San Gallicano, Dermatologic Institute for Research and Care, Rome, Italy.
Luca
L
Muscardin
Department of Plastic and Reconstructive Surgery, San Gallicano, Dermatologic Institute for Research and Care, Rome, Italy.
Stefania
S
Bucher
D000328:Adult; D018223:Dermatofibrosarcoma / Q000188:drug therapy* / Q000473:pathology; D053672:Electrochemotherapy; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009916:Orbital Diseases / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D011788:Quality of Life; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
Dermatofibrosarcoma protuberans; electrochemotherapy; ocular area; quality of life