The effect of medical versus surgical treatment of spontaneous miscarriage on subsequent in vitro fertilization cycles.
OBJECTIVE
To evaluate the effect of dilation and curettage (D&C) and misoprostol as treatments for spontaneous miscarriage (SM) on in vitro fertilization (IVF) parameters in the subsequent IVF cycle.


METHODS
Multicenter, retrospective, cohort study. Women treated for SM after IVF treatment with D&C or misoprostol and underwent a subsequent IVF cycle was included. The main outcome measures were ovarian response, endometrial thickness and pregnancy rate in the subsequent IVF cycle after MA.


RESULTS
Among 73 patients with miscarriage, 41 had D&C and 32 were given misoprostol. Baseline serum follicle stimulating hormone (FSH) levels and ovarian responses before and after treatment of miscarriage were comparable. No significant differences were observed between the D&C and the misoprostol groups in basal FSH levels, endometrial thickness and parameters of ovarian response in the subsequent IVF cycle.


CONCLUSIONS
D&C and misoprostol are both effective treatments for IVF patients with miscarriage, without an adverse effect on subsequent IVF treatment outcome.
a IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center , Kfar Saba , Israel .|b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel .
Rina
R
Tamir
b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel .|c IVF Unit, Department of Obstetrics and Gynecology Wolfson Medical Center , Holon , Israel .
Sarit
S
Allouche
b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel .|c IVF Unit, Department of Obstetrics and Gynecology Wolfson Medical Center , Holon , Israel .
Ariel
A
Weissman
a IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center , Kfar Saba , Israel .|b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel .
Einat
E
Haikin Herzberger
d IVF Unit, Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center , Hadera , Israel , and.|e Faculty of Medicine , Technion-Israel Institute of Technology , Haifa , Israel.
Suzi
S
Oberman-Farhi
d IVF Unit, Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center , Hadera , Israel , and.|e Faculty of Medicine , Technion-Israel Institute of Technology , Haifa , Israel.
Einat
E
Shalom-Paz
a IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center , Kfar Saba , Israel .|b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel .
Adrian
A
Shulman
a IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center , Kfar Saba , Israel .|b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel .
Amir
A
Wiser
D000022:Abortion, Spontaneous / Q000188:drug therapy* / Q000601:surgery*; D000328:Adult; D004107:Dilatation and Curettage; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use*; D010120:Oxytocics / Q000627:therapeutic use*; D011247:Pregnancy; D012189:Retrospective Studies
D010120:Oxytocics; D016595:Misoprostol
D&C; IVF; lag period; miscarriage; misoprostol