Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light.
A novel cancer cell lysosome-targetable multifunctional NO-delivery nanoplatform (Lyso-Ru-NO@FA@C-TiO2) (1) was developed. It selectively targets folate-receptor overexpressed cancer cells and specifically locates within the lysosome organelle to which NO and reactive oxygen species are simultaneously released upon 808 nm NIR light irradiation. The dual-targeted nanoplatform (1) demonstrated the highest anticancer efficacy compared with nontargeted counterparts under NIR light sensitization.
Key Laboratory for Advanced Materials of MOE & Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China. liujingang@ecust.edu.cn.
Hui-Jing
HJ
Xiang
Key Laboratory for Advanced Materials of MOE & Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China. liujingang@ecust.edu.cn.
Qiao
Q
Deng
Key Laboratory of Resource Chemistry of MOE & Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, 200234, P. R. China.
Lu
L
An
Key Laboratory for Advanced Materials of MOE & Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China. liujingang@ecust.edu.cn.
Min
M
Guo
Key Laboratory of Resource Chemistry of MOE & Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, 200234, P. R. China.
Shi-Ping
SP
Yang
Key Laboratory for Advanced Materials of MOE & Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China. liujingang@ecust.edu.cn.
Jin-Gang
JG
Liu
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000494:pharmacology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000008:administration & dosage* / Q000494:pharmacology; D014025:Titanium / Q000737:chemistry*
D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; C009495:titanium dioxide; D009569:Nitric Oxide; D014025:Titanium