MT1-MMP: Endosomal delivery drives breast cancer metastasis.
The membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.
Institute for Medical Microbiology, Virology, and Hygiene, University Medical Center Eppendorf, 20246 Hamburg, Germany s.linder@uke.de.
Stefan
S
Linder
D020727:ADP-Ribosylation Factors / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D005260:Female; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D064726:Triple Negative Breast Neoplasms / Q000473:pathology*
D048868:Adaptor Proteins, Signal Transducing; D009419:Nerve Tissue Proteins; D053511:Matrix Metalloproteinase 14; D020727:ADP-Ribosylation Factors