Invasive Cervical Cancer and Antidepressants: A Nationwide Population-Based Study.
To our knowledge, no prior population-based study has been published wherein the primary aim was to evaluate whether an association between psychotropic drug prescription and cervical cancer exists. Herein we have conducted the first study that primarily aimed to determine the association between antidepressants use and risk of invasive cervical cancer in the general population.This is a population-based study utilizing Taiwan's National Health Insurance Research Database. We identified 26,262 cases with invasive cervical cancer and 129,490 controls. We adopted the conditional logistic regression model as the statistical method and adjusted for potential confounding factors.The prescription of selective serotonin reuptake inhibitors (SSRIs) (adjusted OR = 0.93, 95% CI = 0.84-1.04), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), serotonin norepinephrine reuptake inhibitors (SNRIs), mirtazapine and bupropion, adjusting for cumulative dose, was not associated with an increased, or decreased, risk for invasive cervical cancer. An association between trazodone prescription and invasive cervical cancer was observed (adjusted OR = 1.22, 95% CI = 1.03-1.43).An association between the major classes of antidepressants and invasive cervical cancer was not observed herein. Our preliminary finding regarding a possible association between trazodone and cervical cancer requires replication.
From the Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan (HLC, YHH, CFL, HYL); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (HLC, YHH, CFL, HYL, VCHC); Department of Speech, Language Pathology and Audiology, Chung Shan Medical University, Taichung, Taiwan (KYH); Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan (WCC); School of Medicine, Fu Jen Catholic University, Taipei, Taiwan (WCC); Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Canada (YL, RSM); Department of Psychiatry, University of Toronto, Toronto, Canada (RSM); and Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (VCHC).
Hsiang-Lin
HL
Chan
Yi-Hsuan
YH
Hsieh
Chiao-Fan
CF
Lin
Hsin-Yi
HY
Liang
Kuo-You
KY
Huang
Wei-Che
WC
Chiu
Yena
Y
Lee
Roger S
RS
McIntyre
Vincent Chin-Hung
VC
Chen
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D018570:Risk Assessment; D017367:Selective Serotonin Reuptake Inhibitors; D013624:Taiwan; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced* / Q000473:pathology*
D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors