One-Pot Catalysis Using a Chiral Iridium Complex/Brønsted Base: Catalytic Asymmetric Synthesis of Catalponol.
Tandem asymmetric hydrogen transfer oxidation/aldol condensation under relay catalysis of a chiral iridium complex/achiral Brønsted base binary system is described for the synthesis of α-benzylidene-γ-hydroxytetralones with high ee's. A two-step synthesis of catalponol was achieved using this sequential methodology together with regio- and stereoselective hydroboration.
The Institute of Scientific and Industrial Research, Osaka University , Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Takeyuki
T
Suzuki
The Institute of Scientific and Industrial Research, Osaka University , Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Ismiyarto
The Institute of Scientific and Industrial Research, Osaka University , Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Yuka
Y
Ishizaka
The Institute of Scientific and Industrial Research, Osaka University , Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Da-Yang
DY
Zhou
The Institute of Scientific and Industrial Research, Osaka University , Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Kaori
K
Asano
The Institute of Scientific and Industrial Research, Osaka University , Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Hiroaki
H
Sasai