Dynamics of HIV infection in lymphoid tissue network.
Human immunodeficiency virus (HIV) is a fast replicating ribonucleic acid virus, which can easily mutate in order to escape the effects of drug administration. Hence, understanding the basic mechanisms underlying HIV persistence in the body is essential in the development of new therapies that could eradicate HIV infection. Lymphoid tissues are the primary sites of HIV infection. Despite the recent progress in real-time monitoring technology, HIV infection dynamics in a whole body is unknown. Mathematical modeling and simulations provide speculations on global behavior of HIV infection in the lymphatic system. We propose a new mathematical model that describes the spread of HIV infection throughout the lymphoid tissue network. In order to represent the volume difference between lymphoid tissues, we propose the proportionality of several kinetic parameters to the lymphoid tissues' volume distribution. Under this assumption, we perform extensive numerical computations in order to simulate the spread of HIV infection in the lymphoid tissue network. Numerical computations simulate single drug treatments of an HIV infection. One of the important biological speculations derived from this study is a drug saturation effect generated by lymphoid network connection. This implies that a portion of reservoir lymphoid tissues to which drug is not sufficiently delivered would inhibit HIV eradication despite of extensive drug injection.
Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan. snakaoka@m.u-tokyo.ac.jp.
Shinji
S
Nakaoka
Department of Biology, Kyushu University, Fukuoka, 812-8581, Japan.
Shingo
S
Iwami
Institute for Virus Research, Kyoto University, Kyoto, 606-8507, Japan.
Kei
K
Sato
D019380:Anti-HIV Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D003198:Computer Simulation; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D008221:Lymphoid Tissue / Q000821:virology*; D055641:Mathematical Concepts; D008954:Models, Biological; D014779:Virus Replication
D019380:Anti-HIV Agents
Combinational drug treatment; HIV infection; Lymphoid tissue network; Mathematical Modeling; Numerical computation; The basic reproduction number