The utility of transposon mutagenesis for cancer studies in the era of genome editing.
The use of transposons as insertional mutagens to identify cancer genes in mice has generated a wealth of information over the past decade. Here, we discuss recent major advances in transposon-mediated insertional mutagenesis screens and compare this technology with other screening strategies.
Meyer Cancer Center, Weill Cornell Medical College, New York, NY, 10021, USA.
Gina M
GM
DeNicola
Meyer Cancer Center, Weill Cornell Medical College, New York, NY, 10021, USA. fak2009@med.cornell.edu.
Florian A
FA
Karreth
Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1HH, UK.
David J
DJ
Adams
Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1HH, UK. cw6@sanger.ac.uk.|Department of Haematology, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK. cw6@sanger.ac.uk.
Chi C
CC
Wong
D000818:Animals; D004251:DNA Transposable Elements; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D016678:Genome; D006801:Humans; D051379:Mice; D016254:Mutagenesis, Insertional / Q000379:methods*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics*
D004251:DNA Transposable Elements