A Positive Twist to the Centromeric Nucleosome.
Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex.
Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Josefina
J
Ocampo
Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: clarkda@mail.nih.gov.
David J
DJ
Clark
D002503:Centromere; D006657:Histones / Q000235:genetics; D009707:Nucleosomes; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics
D006657:Histones; D009707:Nucleosomes; D029701:Saccharomyces cerevisiae Proteins