Treatment for hypoactive sexual desire.
Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors. This gradually disinhibits the turnover of other monoamines like dopamine and noradrenaline that are critical for sexual desire.
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC H4B 1R6, Canada. Electronic address: jim.pfaus@concordia.ca.
James G
JG
Pfaus
D001562:Benzimidazoles / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism; D006801:Humans; D011985:Receptors, Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy* / Q000378:metabolism
D001562:Benzimidazoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C098107:flibanserin