The Case for Synthetic Injectables.
There are several different classes of synthetic dermal fillers and volume enhancers including semipermanent and permanent products available in the United States. Based on clinical and scientific evidence, this article reviews the chemical and polymeric properties, clinical data, patient selection, indications for use, injection technique, and adverse event profiles of permanent synthetic injectables currently used in clinical practice in the United States: medical-grade liquid injectable silicone and polymethyl methacrylate. Understanding the unique characteristics of these two products reinforces the advantages and disadvantages of each, including under what circumstances they should be used and why they perform the way they do.
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D000152:Acne Vulgaris / Q000188:drug therapy*; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000009:adverse effects*; D003357:Cosmetic Techniques / Q000009:adverse effects; D000067548:Dermal Fillers / Q000008:administration & dosage* / Q000009:adverse effects*; D017886:Durapatite / Q000008:administration & dosage / Q000009:adverse effects; D004954:Esthetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D019344:Lactic Acid / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D012060:Rejuvenation / Q000502:physiology; D018570:Risk Assessment; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects; D015595:Skin Aging / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome
D001672:Biocompatible Materials; D000067548:Dermal Fillers; D012828:Silicones; D019344:Lactic Acid; D006820:Hyaluronic Acid; D017886:Durapatite
Acne scarring; Dermal fillers; Liquid injectable silicone; Nasolabial folds; Permanent fillers; Polymethyl methacrylate; Synthetic fillers