Unusual molecular pattern in Ajugoideae subfamily: the case of Ajuga genevensis L. from Dolomites.
We analysed the ethanolic extract from Ajuga genevensis L. (Lamiaceae) growing in Dolomites, part of Italian Alps. Three new compounds for this species were identified: rosmarinic acid (1), oleanolic acid (2) and maslinic acid (3), representative of two different classes of chemical compounds (phenylpropanoids and pentacyclic triterpenes). A. genevensis resulted to be a valuable source of these compounds endowed with interesting biological activities (i.e. antioxidant, neuroprotective, anti-inflammatory, antiproliferative). The recognition of compounds (1), (2) and (3) may also confirm the ethnomedicinal uses of this plant. From a chemotaxonomical point of view, it is worth noting that iridoids were not evidenced in this accession. Iridoids are considered chemotaxonomic marker in Lamiales, and, in contrast with a previous study on this species, the presence of aucubin was not confirmed. In addition, the presence of large amounts of rosmarinic acid (1) was unexpected for a species that does not belong to subfamily Nepetoideae.
a Dipartimento di Chimica , Università di Roma "La Sapienza" , Roma , Italy.|b Dipartimento di Biologia Ambientale , Università di Roma "La Sapienza" , Roma , Italy.
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Venditti
b Dipartimento di Biologia Ambientale , Università di Roma "La Sapienza" , Roma , Italy.
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Frezza
a Dipartimento di Chimica , Università di Roma "La Sapienza" , Roma , Italy.
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Riccardelli
b Dipartimento di Biologia Ambientale , Università di Roma "La Sapienza" , Roma , Italy.
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Foddai
b Dipartimento di Biologia Ambientale , Università di Roma "La Sapienza" , Roma , Italy.
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Nicoletti
b Dipartimento di Biologia Ambientale , Università di Roma "La Sapienza" , Roma , Italy.
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Serafini
a Dipartimento di Chimica , Università di Roma "La Sapienza" , Roma , Italy.
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Bianco
D031328:Ajuga / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002934:Cinnamates / Q000032:analysis; D053630:Depsides / Q000032:analysis; D057888:Iridoid Glucosides / Q000032:analysis; D039823:Iridoids / Q000032:analysis; D007558:Italy; D008519:Medicine, Traditional; D018696:Neuroprotective Agents / Q000494:pharmacology; D009828:Oleanolic Acid / Q000032:analysis / Q000031:analogs & derivatives; D010936:Plant Extracts / Q000032:analysis*; D014315:Triterpenes / Q000032:analysis; D000097123:Rosmarinic Acid
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D002934:Cinnamates; D053630:Depsides; D057888:Iridoid Glucosides; D039823:Iridoids; D018696:Neuroprotective Agents; D009828:Oleanolic Acid; D010936:Plant Extracts; D014315:Triterpenes; D000097123:Rosmarinic Acid; C006650:aucubin; C412811:maslinic acid
Ajuga genevensis Lamiaceae; ethnopharmacology; pentacyclic triterpenes; phenylpropanoids