Cellular and chromatin dynamics of antibody-secreting plasma cells.
Plasma cells are terminally differentiated B cells responsible for maintaining protective serum antibody titers. Despite their clinical importance, our understanding of the linear genomic features and chromatin structure of plasma cells is incomplete. The plasma cell differentiation program can be triggered by different signals and in multiple, diverse peripheral B cell subsets. This heterogeneity raises questions about the gene regulatory circuits required for plasma cell specification. Recently, new regulators of plasma cell differentiation have been identified and the enhancer landscapes of naïve B cells have been described. Other studies have revealed that the bone marrow niche harbors heterogeneous plasma cell subsets. Still undefined are the minimal requirements to become a plasma cell and what molecular features make peripheral B cell subsets competent to become antibody-secreting plasma cells. New technologies promise to reveal underlying chromatin configurations that promote efficient antibody secretion. For further resources related to this article, please visit the WIREs website.
Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Alexandra
A
Bortnick
Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Cornelis
C
Murre
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D002454:Cell Differentiation; D042002:Chromatin Assembly and Disassembly; D053263:Gene Regulatory Networks; D006801:Humans