A Review of Computational Methods to Predict the Risk of Rupture of Abdominal Aortic Aneurysms.
Computational methods have played an important role in health care in recent years, as determining parameters that affect a certain medical condition is not possible in experimental conditions in many cases. Computational fluid dynamics (CFD) methods have been used to accurately determine the nature of blood flow in the cardiovascular and nervous systems and air flow in the respiratory system, thereby giving the surgeon a diagnostic tool to plan treatment accordingly. Machine learning or data mining (MLD) methods are currently used to develop models that learn from retrospective data to make a prediction regarding factors affecting the progression of a disease. These models have also been successful in incorporating factors such as patient history and occupation. MLD models can be used as a predictive tool to determine rupture potential in patients with abdominal aortic aneurysms (AAA) along with CFD-based prediction of parameters like wall shear stress and pressure distributions. A combination of these computer methods can be pivotal in bridging the gap between translational and outcomes research in medicine. This paper reviews the use of computational methods in the diagnosis and treatment of AAA.
School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 ; Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553.
Tejas
T
Canchi
Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553.
S D
SD
Kumar
School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798.
E Y K
EY
Ng
Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433.
Sriram
S
Narayanan
D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology*; D001696:Biomechanical Phenomena; D002319:Cardiovascular System / Q000503:physiopathology*; D003198:Computer Simulation; D018450:Disease Progression; D006801:Humans; D057446:Hydrodynamics; D007091:Image Processing, Computer-Assisted; D000069550:Machine Learning; D008955:Models, Cardiovascular; D009420:Nervous System / Q000503:physiopathology*; D012307:Risk Factors