A new polyketide, penicillolide from the marine-derived fungus Penicillium sacculum.
A new polyketide, penicillolide (1) was isolated from the fermentation broth of the marine-derived fungus Penicillium sacculum GT-308. Compound 1 is a polyketide with a unique carbon skeleton. The structure of this compound was established via extensive spectroscopic analyses including 1D-, 2D-NMR, and HRESI-MS.
a Department of Natural Products Chemistry, School of Pharmacy , China Medical University , Shenyang , China.
Tao
T
Liu
b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.
Songya
S
Zhang
b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.
Zhanlin
Z
Li
a Department of Natural Products Chemistry, School of Pharmacy , China Medical University , Shenyang , China.
Yu
Y
Wang
c Department of the Central Laboratory, School of Pharmacy , China Medical University , Shenyang , China.
Zaixing
Z
Chen
b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.
Jiao
J
Bai
d Qingdao Key Lab of Analytical Technology Development and Standardization of Chinese Medicines , The First Institute of Oceanography SOA , Qingdao , China.|e Department of Biology , Qingdao University of Science & Technology , Qingdao , China.
Li
L
Tian
b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.
Yuehu
Y
Pei
b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.
Huiming
H
Hua
D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000737:chemistry* / Q000378:metabolism; D061065:Polyketides / Q000032:analysis* / Q000737:chemistry; D012623:Seawater / Q000382:microbiology; D021241:Spectrometry, Mass, Electrospray Ionization
D061065:Polyketides; C000611783:penicillolide
Marine-derived fungus; Penicillium sacculum; penicillolide; polyketide