Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development.
Our sophisticated thoughts and behaviors are based on the miraculous development of our complex nervous network system, in which many different types of proteins and signaling cascades are regulated in a temporally and spatially ordered manner. Here we review our recent attempts to grasp the principles of nervous system development in terms of general cellular phenomena and molecules, such as volume-regulated anion channels, intracellular Ca(2+) and cyclic nucleotide signaling, the Npas4 transcription factor and the FLRT family of axon guidance molecules. We also present an example illustrating that the same FLRT family may regulate the development of vascular networks as well. The aim of this review is to open up new vistas for understanding the intricacy of nervous and vascular system development.
Department of Neurophysiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan. tenpak@hama-med.ac.jp.
Tenpei
http://orcid.org/0000-0003-4614-4504
T
Akita
Department of Occupational Therapy, Faculty of Health and Medical Sciences, Tokoha University, 1230 Miyakoda-cho, Kita-ku, Hamamatsu, Shizuoka, 431-2102, Japan.
Tatsuro
T
Kumada
Laboratory for Molecular Biology of Neural System, Advanced Medical Research Center, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
Sei-ichi
S
Yoshihara
Molecular and Developmental Neurobiology Group, Biomedical Research Institute of Lleida (IRBLleida), University of Lleida, 25198, Lleida, Spain.
Joaquim
J
Egea
Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
Satoru
S
Yamagishi
D000818:Animals; D001808:Blood Vessels / Q000378:metabolism* / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism* / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*
D007473:Ion Channels; D014157:Transcription Factors; D002118:Calcium
Anion channel; Axon guidance; Intracellular signaling; Nervous system development; Transcription factor; Vascular system development