COMPARATIVE ANALYSIS OF COMBINED COURSE OF CHRONIC HEPATITIS C AND HIV DEPENDING ON THE ROUTE OF INFECTION.
At present, an infection caused by the hepatitis C virus is common among HIV-infected patients. The rapid growth of drug addiction, sexual route of infection transmission, HIV and HCV infection among young people, low efficiency of treatment and lack of specific means of prevention clearly means that this pathology is to be listed among the first in the modern infectology. The aim of the study was to investigate the characteristics of the course of chronic hepatitis C in HIV-infected patients, depending on the route of infection. Study design was open, non-randomized and prospective. A total of 58 HIV-infected patients with chronic hepatitis C registered in the dispensary at Karaganda Regional Center for Prevention and Control of AIDS were examined. The diagnosis of HIV infection was verified by immune blotting. Etiological hepatitis verification was performed by means of enzyme immunoassay and polymerase chain reaction. We present the clinical and laboratory results of HIV-infected patients with chronic hepatitis C, depending on the route of infection. Patients with the sexually transmitted infection experienced asymptomatic course of the disease. In comparison, injecting drug users showed greater clinical symptomatology and a moderate level of activity of the infectious process. These clinical and laboratory findings suggest that the characteristics of the course of chronic hepatitis C in HIV-infected patients depends on the route of infection.
Karaganda State Medical University, Kazakhstan; D. Tvildiani Medical University, Tbilisi, Georgia.
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Sarsekeyeva
Karaganda State Medical University, Kazakhstan; D. Tvildiani Medical University, Tbilisi, Georgia.
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Kosherova
Karaganda State Medical University, Kazakhstan; D. Tvildiani Medical University, Tbilisi, Georgia.
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N
Tabagari-Bregvadze
D000328:Adult; D060085:Coinfection / Q000503:physiopathology / Q000635:transmission* / Q000821:virology; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000503:physiopathology / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000302:isolation & purification; D016174:Hepacivirus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000503:physiopathology / Q000635:transmission* / Q000821:virology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D015819:Substance Abuse, Intravenous / Q000503:physiopathology*; D047568:Unsafe Sex