Platelets Contribute to BBB Disruption Induced by HIV and Alcohol.
The role of platelets in the neurological diseases that underlie cognitive impairment has attracted increasing attention in recent years. Multiple pathways in platelets contribute to host defenses, as well as to CNS function. In the current study, we hypothesize that the Blood Brain Barrier (BBB) is disrupted when exposed to platelets from patients with triple Co-morbidity (hazardous alcohol users+ HIV+ thrombocytopenia), compared to those with dual, single or no morbidity (HIV only, alcohol only or healthy controls).
Professor and Chair, Institute of Neuro-Immune Pharmacology, Department of Immunology, Florida International University, Miami, FL, USA.
Madhavan
M
Nair
Professor, School of Integrated Health and Science, Department of Art and Science, Florida International University, Miami, FL, USA.
Jose Mb
JM
Maria
Institute of Neuro-Immune Pharmacology, Department of Immunology, Florida International University, Miami, FL, USA.
Marisela
M
Agudelo
Institute of Neuro-Immune Pharmacology, Department of Immunology, Florida International University, Miami, FL, USA.
Adriana
A
Yndart
School of Integrated Science and Humanity, College of Arts and Sciences, Florida International University, Miami, FL, USA.
Mayra E
ME
Vargas-Rivera
Alcohol; Blood Brain Barrier; HIV; Neuro-Inflammation; Platelets; Thrombocytopenia