Periplanosides A-C: new insect-derived dihydroisocoumarin glucosides from Periplaneta americana stimulating collagen production in human dermal fibroblasts.
Three new dihydroisocoumarin glucosides, termed periplanosides A-C (1-3), a known analog, pericanaside (4), and the other twenty known compounds were isolated from the insect Periplaneta americana. Their structures including absolute configurations were determined by comprehensive spectroscopic analyses and computational methods. Biological evaluation showed that compound 2 could stimulate collagen production by 31.2% in human dermal fibroblasts-adult (HDFa) at the concentration of 30 μM, indicating its significance in skin repair and ulcer.
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.|b College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 610075 , China.
Yong-Xun
YX
Yang
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
Qi
Q
Luo
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
Bo
B
Hou
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
Yong-Ming
YM
Yan
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
Yue-Hu
YH
Wang
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
Jian-Jun
JJ
Tang
b College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 610075 , China.
Xiao-Ping
XP
Dong
c Sichuan Gooddoctor-Panxi Pharmaceutical Co., Ltd , Xichang 615000 , China.
Xiu-Ying
XY
Ma
d The First People's Hospital of Yunnan Province , Kunming 650032 , China.
Tong-Hua
TH
Yang
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
Zhi-Li
ZL
Zuo
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.|b College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 610075 , China.
Yong-Xian
YX
Cheng
D000328:Adult; D000818:Animals; D003094:Collagen / Q000096:biosynthesis / Q000187:drug effects; D005347:Fibroblasts / Q000378:metabolism; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010526:Periplaneta / Q000737:chemistry*
D005960:Glucosides; D049934:Isocoumarins; C000604765:periplanoside A; C000604766:periplanoside B; C000604767:periplanoside C; D003094:Collagen
Periplaneta americana; collagen I production; human dermal fibroblasts-adult; insect; isocoumarin