The Effect of Blood Loss in the Presence and Absence of Severe Soft Tissue Injury on Hemodynamic and Metabolic Parameters; an Experimental study.
BACKGROUND
The effect of severe soft tissue injury on the severity of hemorrhagic shock is still unknown. Therefore, the present study was aimed to determine hemodynamic and metabolic changes in traumatic/hemorrhagic shock in an animal model.


METHODS
Forty male rats were randomly divided into 4 equal groups including sham, hemorrhagic shock, soft tissue injury, and hemorrhagic shock + soft tissue injury groups. The changes in blood pressure, central venous pressure (CVP) level, acidity (pH), and base excess were dynamically monitored and comparedsented.


RESULTS
Mean arterial blood pressure decreased significantly in hemorrhagic shock (df: 12; F=10.9; p<0.001) and severe soft tissue injury + hemorrhagic shock (df: 12; F=11.7; p<0.001) groups 15 minutes and 5 minutes after injury, respectively. A similar trend was observed in CVP in severe soft tissue injury + hemorrhagic shock group (df: 12; F=8.9; p<0.001). After 40 minutes, pH was significantly lower in hemorrhagic shock (df: 12; F=6.8; p=0.009) and severe soft tissue injury + hemorrhagic shock (df: 12; F=7.9; p=0.003) groups. Base excess changes during follow ups have a similar trend. (df: 12; F=11.3; p<0.001).


CONCLUSIONS
The results of this study have shown that the effect of hemorrhage on the decrease of mean arterial blood pressure, CVP, pH, and base excess is the same in the presence or absence of soft tissue injury.
Department of Surgery, Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ali Mohammad
AM
Moradi
Department of Surgery, Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Omid
O
Aj
Department of Surgery, Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shahram
S
Paydar
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Farzaneh
F
Ketabchi
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Mostafa
SM
Sheid Moosavi
Department of Surgery, Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shahram
S
Bolandparvaz
Department of Surgery, Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Hamid Reza
HR
Abassi
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Aryan Dokht
AD
Tamadon
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Davood
D
Mehrabani
Shock; hemodynamics; hemorrhagic; soft tissue injuries