Impact of image-based motion correction on dopamine D3/D2 receptor occupancy-comparison of groupwise and frame-by-frame registration approaches.
BACKGROUND
Image registration algorithms are frequently used to align the reconstructed brain PET frames to remove subject head motion. However, in occupancy studies, this is a challenging task where competitive binding of a drug can further reduce the available signal for registration. The purpose of this study is to evaluate two kinds of algorithms-a conventional frame-by-frame (FBF) registration and a recently introduced groupwise image registration (GIR), for motion correction of a dopamine D3/D2 receptor occupancy study.


METHODS
The FBF method co-registers all the PET frames to a common reference based on normalised mutual information as the spatial similarity. The GIR method incorporates a pharmacokinetic model and conducts motion correction by maximising a likelihood function iteratively on tracer kinetics and subject motion. Data from eight healthy volunteers scanned with [11C]-(+)-PHNO pre- and post-administration of a range of doses of the D3 antagonist GSK618334 were used to compare the motion correction performance.


RESULTS
The groupwise registration achieved improved motion correction results, both by visual inspection of the dynamic PET data and by the reduction of the variability in the outcome measures, and required no additional steps to exclude unsuccessfully realigned PET data for occupancy modelling as compared to frame-by-frame registration. Furthermore, for the groupwise method, the resultant binding potential estimates had reduced variation and bias for individual scans and improved half maximal effective concentration (EC50) estimates were obtained for the study as a whole.


CONCLUSIONS
These results indicate that the groupwise registration approach can provide improved motion correction of dynamic brain PET data as compared to frame-by-frame registration approaches for receptor occupancy studies.
Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK.|Imanova Limited, Hammersmith Hospital, 2nd Floor, Burlington Danes Building, London, UK.
Jieqing
J
Jiao
Imanova Limited, Hammersmith Hospital, 2nd Floor, Burlington Danes Building, London, UK.
Graham E
GE
Searle
Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK.
Julia A
JA
Schnabel
Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK. roger.gunn@imanova.co.uk.|Imanova Limited, Hammersmith Hospital, 2nd Floor, Burlington Danes Building, London, UK. roger.gunn@imanova.co.uk.|Department of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK. roger.gunn@imanova.co.uk.
Roger N
RN
Gunn
Groupwise registration; Motion correction; PET; Pharmacokinetic modelling; Receptor occupancy studies