[Expression of TREM-1 in patients with invasive cervical cancer and precursor lesions].
BACKGROUND
It has been shown that the TREM-1 glycoprotein belongs to the immunoglobulin superfamily that induces secretion of various proinflammatory cytokines. The aim of this study was to measure the expression of TREM-1 in patients with cervical cancer.


METHODS
In this cross-sectional study we included four groups of patients: GI: women with low-grade squamous intraepithelial lesion (IL) (n = 15 p / g); GII: patients with high-grade squamous IL (n = 9 w / g); GIII: patients with invasive cervical cancer (n = 9 p / g) and GIV: healthy patients (n = 15 p / g). In all patients the expression of TREM-1 and the Average Fluorescence Index (AFI) in neutrophils and monocytes were measured, as well as levels of leukocytes, neutrophils and monocytes. We used Student's t test for independent samples. For these variables, we applied Mann-Whitney rank-sum, ANOVA, and Tukey tests. Chi square test was used for qualitative variables.


RESULTS
The percentages of TREM-1 expression in neutrophils and monocytes, plus the AFI in neutrophils in the 4 groups was not significantly different. The AFI of TREM-1 in monocytes was significantly different when comparing group II and group III versus group IV (p < 0.02). There was also no significant difference when comparing the mean values of leukocytes, neutrophils and monocytes in the different groups.


CONCLUSIONS
This study shows increased expression of TREM-1 in monocytes from patients with advanced cancer.
Dirección de Educación e Investigación en Salud, Unidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia "Lic. Ignacio García Téllez", Centro Médico Nacional de Occidente, Guadalajara, Jalisco, México. robana@prodigy.net.mx.
Roberto
R
Anaya-Prado
Fabiola Geovanna
FG
Norzgaray-Ibarra
Alejandro
A
Bravo-Cuéllar
Carlos Eduardo
CE
Pérez-Avila
Daniel
D
Schadegg-Peña
Michelle M
MM
Anaya-Fernández
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology; D011971:Receptors, Immunologic / Q000378:metabolism*; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000378:metabolism* / Q000473:pathology; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
Atypical squamous cells of the cervix; Myeloid cells; Uterine cervical neoplasms