Maternal Effects of Respiratory Syncytial Virus Infection during Pregnancy.
Given the illness and deaths caused by respiratory syncytial virus (RSV) infection during the first year of life, preventing infant RSV infections through maternal vaccination is intriguing. However, little is known about the extent and maternal effects of RSV infection during pregnancy. We describe 3 cases of maternal RSV infection diagnosed at a US center during winter 2014. Case-patient 1 (26 years old, week 33 of gestation) received a diagnosis of RSV infection and required mechanical ventilation. Case-patient 2 (27 years old, week 34 of gestation) received a diagnosis of infection with influenza A(H1N1) virus and RSV and required mechanical ventilation. Case-patient 3 (21 years old, week 32 of gestation) received a diagnosis of group A streptococcus pharyngitis and RSV infection and was monitored as an outpatient. Clarifying the effects of maternal RSV infection could yield valuable insights into potential maternal and fetal benefits of an effective RSV vaccination program.
Sarahn M
SM
Wheeler
Sarah
S
Dotters-Katz
R Phillip
RP
Heine
Chad A
CA
Grotegut
Geeta K
GK
Swamy
D000328:Adult; D005260:Female; D006801:Humans; D000068097:Maternal Health; D011247:Pregnancy; D018357:Respiratory Syncytial Virus Infections / Q000517:prevention & control; D018113:Respiratory Syncytial Virus, Human / Q000472:pathogenicity*; D012141:Respiratory Tract Infections / Q000150:complications / Q000821:virology*; D014611:Vaccination
RSV; infection; maternal; pregnancy; respiratory syncytial virus; viruses