Current Applications and Future Prospects of Stem Cells in Dentistry.
Stem cells are defined as clonogenic, unspecialized cells capable of both selt-renewal and multi-lineage differentiation, contributing to regenerating specific tissues. For years, restorative treatments have exploited the lifelong regenerative potential of dental pulp stem cells to give rise to tertiary dentine, which is therapeutically employed for direct and indirect pulp capping. Current applications of stem cells in endodontic research have revealed their potential to continue root development in necrotic immature teeth and transplanted/replanted teeth. Successful application of pulp revascularization is highlighted here with support of a clinical case report. This article also discusses the role of dental stem cells as a promising tool for regeneration of individual tissue types like dentine, pulp and even an entire functional tooth.
Sharmila
S
Surendran
Gautham
G
Sivamurthy
D017607:Aluminum Compounds / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D056624:Apexification / Q000379:methods; D017610:Calcium Compounds / Q000627:therapeutic use; D002648:Child; D003782:Dental Pulp / Q000502:physiology*; D003786:Dental Pulp Cavity / Q000502:physiology; D003804:Dentin / Q000502:physiology; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D007180:Incisor / Q000293:injuries; D018919:Neovascularization, Physiologic / Q000502:physiology; D010087:Oxides / Q000627:therapeutic use; D011672:Pulpotomy / Q000379:methods; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D017640:Silicates / Q000627:therapeutic use; D013234:Stem Cells / Q000145:classification / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014082:Tooth Fractures / Q000628:therapy; D014090:Tooth Replantation / Q000379:methods; D019553:Tooth, Nonvital / Q000628:therapy
D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate