Higher Fasting Plasma Glucose Levels, within the Normal Range, are Associated with Decreased Processing Speed in High Functioning Young Elderly.
We explored the association of plasma glucose levels within the normal range with processing speed in high functioning young elderly, free of type 2 diabetes mellitus (T2DM). A sample of 41 participants (mean age = 64.7, SD = 10; glucose 94.5 mg/dL, SD = 9.3), were examined with a computerized cognitive battery. Hierarchical linear regression analysis showed that higher plasma glucose levels, albeit within the normal range (<110 mg/dL), were associated with longer reaction times (p <  0.01). These findings suggest that even in the subclinical range and in the absence of T2DM, monitoring plasma glucose levels may have an impact on cognitive function.
Behavioral Sciences, Academic College of Tel Aviv-Yaffo, Israel.
Meytal
M
Raizes
Behavioral Sciences, Academic College of Tel Aviv-Yaffo, Israel.
Odelia
O
Elkana
Behavioral Sciences, Academic College of Tel Aviv-Yaffo, Israel.
Motty
M
Franko
Department of Psychiatry, Sheba Medical Center, Israel.|Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ramit
R
Ravona Springer
Institute of Medical Screening, Sheba Medical Center Tel Hashomer, Israel.
Shlomo
S
Segev
Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel.|The Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA.
Michal Schnaider
MS
Beeri
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003071:Cognition / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D005215:Fasting / Q000502:physiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values
D001786:Blood Glucose
Plasma glucose level; cognitive function; processing speed; type 2 diabetes