Swim Training Improves HOMA-IR in Type 2 Diabetes Induced by High Fat Diet and Low Dose of Streptozotocin in Male Rats.
OBJECTIVE
Insulin resistance plays a key role in the onset and development of type 2 diabetes mellitus (T2DM) and its complications. In this study, we evaluated the effect of swim training on insulin resistance in diabetic rats.


METHODS
Forty male Wistar rats were randomly divided into four groups (n=10): sedentary control (Con), sedentary diabetic (Dia), swim trained control (Exe) and swim trained diabetic (Dia+Exe) rats. Diabetes was induced by high fat diet (HFD) and a low dose of streptozotocin (35 mg/kg, i.p). In trained groups, one week after the induction of diabetes, animals were subjected to swimming (60 min/5 days a week) for 10 weeks. At the end of training, fasting blood sugar (FBS), oral glucose tolerance test (OGTT), fasting/basal insulin, glycosylated hemoglobin (HbA1c) levels, insulin resistance index, homeostasis model assessment method (HOMA-IR), triglycerides (TG,) total cholesterol (TCh), and high density lipoprotein (HDL) levels in blood were measured.


RESULTS
Swimming significantly improved OGTT (P<0.01) and HOMA-IR (P<0.01). Swim training also significantly decreased FBS (p<0.01), fasting/basal insulin (P<0.01), HbA1C (p<0.01), TG (P<0.05), and TCh (P<0.05) levels. It also significantly increased HDL (p<0.05) level.


CONCLUSIONS
Our findings indicate that swim training improved glycemic control and insulin sensitivity in type 2 diabetes caused by high fat diet in male rats.
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rafigheh
R
Ghiasi
Research Center for Molecular Medicine, Hormozgan University of Medical Sciences, Bandar-Abbas, Iran.
Farhad
F
Ghadiri Soufi
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Hossein
MH
Somi
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Gisou
G
Mohaddes
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Fariba
F
Mirzaie Bavil
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Roya
R
Naderi
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Reza
MR
Alipour
HOMA-IR; High fat diet; Insulin resistance; Rat; Swim training