Chondrosarcoma of the femur in Mazabraud's syndrome: A first case study.
Malignant transformation of fibrous dysplasia (FD) in long bones is rare (less than 1% of cases) and occurs in the form of osteosarcomas. They can occur on FD associated with multiple myxomas, which corresponds to Mazabraud syndrome. To our knowledge, only six cases of FD malignant transformation into osteosarcoma in the context of Mazabraud syndrome have been described. Here, we describe the first case of malignant transformation of femur FD into chondrosarcoma in a 51-year-old female patient. The patient had significant changes in the size and number of myxomas around the femur before the malignant transformation into chondrosarcoma. She underwent complete femur replacement with a favourable result after 4 years' follow-up. Close surveillance is strongly recommended in this syndrome, particularly when the number and size of myxomas increase.
Service d'orthopédie A, hôpital Salengro, CHRU de Lille, 1, rue Émile-Laine, 59037 Lille cedex, France; Université Lille-Nord-de-France, 59000 Lille, France. Electronic address: arcadia.szymanski@gmail.com.
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Szymanski
Service d'orthopédie A, hôpital Salengro, CHRU de Lille, 1, rue Émile-Laine, 59037 Lille cedex, France; Université Lille-Nord-de-France, 59000 Lille, France.
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Bourgault
Université Lille-Nord-de-France, 59000 Lille, France; Centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59000 Lille, France.
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Penel
Service d'orthopédie A, hôpital Salengro, CHRU de Lille, 1, rue Émile-Laine, 59037 Lille cedex, France; Université Lille-Nord-de-France, 59000 Lille, France.
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Maynou
D002471:Cell Transformation, Neoplastic; D002813:Chondrosarcoma / Q000175:diagnosis*; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis*; D005357:Fibrous Dysplasia of Bone / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009232:Myxoma / Q000175:diagnosis*; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000175:diagnosis*; D012983:Soft Tissue Neoplasms / Q000175:diagnosis*; D013577:Syndrome; D013848:Thigh
Chondrosarcoma; Fibrous dysplasia; Malignant transformation; Mazabraud