Analgesic Drugs Alter Connective Tissue Remodeling and Mechanical Properties.
Exercising individuals commonly consume analgesics, but these medications alter tendon and skeletal muscle connective tissue properties, possibly limiting a person from realizing the full benefits of exercise training. I detail the novel hypothesis that analgesic medications alter connective tissue structure and mechanical properties by modifying fibroblast production of growth factors and matrix enzymes, which are responsible for extracellular matrix remodeling.
Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ.
Chad C
CC
Carroll
D000700:Analgesics / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000187:drug effects* / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005109:Extracellular Matrix / Q000201:enzymology / Q000502:physiology; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D013710:Tendons / Q000187:drug effects / Q000502:physiology
D000700:Analgesics; D036341:Intercellular Signaling Peptides and Proteins; D003094:Collagen