Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms.
Endocrine disrupting chemicals (EDC) are released into environment from different sources. They are mainly used in packaging industries, pesticides and food constituents. Clinical evidence, experimental models, and epidemiological studies suggest that EDC have major risks for human by targeting different organs and systems in the body. Multiple mechanisms are involved in targeting the normal system, through estrogen receptors, nuclear receptors and steroidal receptors activation. In this review, different methods by which xenobiotics stimulate signaling pathways and genetic mutation or DNA methylation have been discussed. These methods help to understand the results of xenobiotic action on the endocrine system. Endocrine disturbances in the human body result in breast cancer, ovarian problems, thyroid eruptions, testicular carcinoma, Alzheimer disease, schizophrenia, nerve damage and obesity. EDC characterize a wide class of compounds such as organochlorinated pesticides, industrial wastes, plastics and plasticizers, fuels and numerous other elements that exist in the environment or are in high use during daily life. The interactions and mechanism of toxicity in relation to human general health problems, especially endocrine disturbances with particular reference to reproductive problems, diabetes, and breast, testicular and ovarian cancers should be deeply investigated. There should also be a focus on public awareness of these EDC risks and their use in routine life. Therefore, the aim of this review is to summarize all evidence regarding different physiological disruptions in the body and possible involved mechanisms, to prove the association between endocrine disruptions and human diseases.
Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran 1417614411, Iran; Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan.
Faheem
F
Maqbool
School of Pharmacy, Ardebil University of Medical Sciences, Ardebil, Iran.
Sara
S
Mostafalou
Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran 1417614411, Iran.
Haji
H
Bahadar
Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran 1417614411, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Mohammad.Abdollahi@UToronto.Ca.
Mohammad
M
Abdollahi
D000818:Animals; D002274:Carcinogens, Environmental / Q000009:adverse effects / Q000633:toxicity; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000633:toxicity; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000633:toxicity; D006728:Hormones / Q000378:metabolism; D006801:Humans; D009420:Nervous System / Q000187:drug effects / Q000378:metabolism; D009765:Obesity / Q000209:etiology / Q000378:metabolism; D012098:Reproduction / Q000187:drug effects
D002274:Carcinogens, Environmental; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D006728:Hormones
Aneuploidy; Bisphenol A; Endocrine disruptors; Environment; Estrogens; Neoplasm; Steroids; Systematic review