Nanoscale UiO-MOF-based luminescent sensors for highly selective detection of cysteine and glutathione and their application in bioimaging.
We report a practical approach, the first of its kind, to construct nanoscale UiO-type metal-organic framework (Mi-UiO-66 and Mi-UiO-67) fluorescent probes for the detection of Cys and GSH. They showed high sensitivity (10(-11) M) and selectivity for Cys and GSH, and their fluorescence imaging of Cys and GSH in living cells was well demonstrated.
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China. yubindong@sdnu.edu.cn.
Yan-An
YA
Li
Chao-Wei
CW
Zhao
Neng-Xiu
NX
Zhu
Qi-Kui
QK
Liu
Gong-Jun
GJ
Chen
Jian-Biao
JB
Liu
Xiao-Dong
XD
Zhao
Jian-Ping
JP
Ma
Shaojun
S
Zhang
Yu-Bin
YB
Dong
D003545:Cysteine / Q000032:analysis*; D005033:Ethylmaleimide / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D005978:Glutathione / Q000032:analysis*; D006367:HeLa Cells; D006801:Humans; D008301:Maleimides / Q000138:chemical synthesis / Q000737:chemistry*; D008956:Models, Chemical; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D015040:Zirconium / Q000737:chemistry
D005456:Fluorescent Dyes; D008301:Maleimides; C000611941:Mi-UiO-66; C000611942:Mi-UiO-67; D009942:Organometallic Compounds; D015040:Zirconium; D005978:Glutathione; D003545:Cysteine; D005033:Ethylmaleimide