[Interferon and bone].
Interferon(IFN)α, β and γ were identified, and demonstrated played a crucial role in regulating immune system. Expression of IFN α and β are both promoted by viral infection, and these factors have been utilized to treat the patients with hepatitis C. Meanwhile, IFN γ is expressed in activated T cells, such as Th1 cells, and also plays a crucial role in immune system. Beside the immune roles, IFNs were demonstrated to regulate bone homeostasis via osteoclasts, osteoblasts or both. In this review, I will discuss the roles of IFNs in bone system.
Department of Orthopaedic Surgery, Keio University School of Medice, Japan.
Takeshi
T
Miyamoto
D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation; D006801:Humans; D007372:Interferons / Q000378:metabolism*; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism; D050794:STAT1 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction
D050794:STAT1 Transcription Factor; D007372:Interferons