Gastric cancer diagnosed after Helicobacter pylori eradication in diabetes mellitus patients.
BACKGROUND
Helicobacter pylori infection is the most important risk factor for gastric cancer, for which eradication therapy is commonly performed. However, gastric cancer is sometimes discovered after successful eradication of H. pylori. Much evidence indicates that diabetes mellitus (DM) is a risk factor for gastric cancer. The incidence and characteristics of gastric cancer diagnosed after H. pylori eradication in DM patients remain to be determined.


METHODS
We followed the clinical course of patients who underwent H. pylori eradication therapy at our institution. Endoscopy was performed before and after eradication. We compared the incidence and clinical characteristics of gastric cancer arising in DM and non-DM patients.


RESULTS
In total, 965 patients who underwent successful eradication (518 DM and 447 non-DM patients) were followed-up for an average of 4.5 years. During the follow-up period, 21 gastric cancers were diagnosed (12 in DM patients and 9 in non-DM patients). The incidence of gastric cancer after eradication was not significantly different between DM and non-DM patients (0.485 and 0.482 %/year, respectively). There was no significant difference in the pathology, diameter, depth, location, or treatment of gastric cancer between patients with and without DM.


CONCLUSIONS
The incidence and characteristics of gastric cancer occurring after H. pylori eradication were comparable between DM and non-DM patients.
The Institute for Adult Diseases, Asahi Life Foundation, 2-2-6 Bakuro-cho, Nihon-Bashi, Chuo-ku, Tokyo, 113-8655, Japan. sakitani-tky@umin.ac.jp.|Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. sakitani-tky@umin.ac.jp.
Kosuke
K
Sakitani
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. hiratay-int@h.u-tokyo.ac.jp.
Yoshihiro
Y
Hirata
The Institute for Adult Diseases, Asahi Life Foundation, 2-2-6 Bakuro-cho, Nihon-Bashi, Chuo-ku, Tokyo, 113-8655, Japan. nobu3szk@yahoo.co.jp.
Nobumi
N
Suzuki
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 7satoki@gmail.com.
Satoki
S
Shichijo
The Institute for Adult Diseases, Asahi Life Foundation, 2-2-6 Bakuro-cho, Nihon-Bashi, Chuo-ku, Tokyo, 113-8655, Japan. ayanai-gi@umin.ac.jp.
Ayako
A
Yanai
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. st8039-fki@umin.ac.jp.
Takako
T
Serizawa
The Institute for Adult Diseases, Asahi Life Foundation, 2-2-6 Bakuro-cho, Nihon-Bashi, Chuo-ku, Tokyo, 113-8655, Japan. ksakamoto.spvir@gmail.com.
Kei
K
Sakamoto
The Institute for Adult Diseases, Asahi Life Foundation, 2-2-6 Bakuro-cho, Nihon-Bashi, Chuo-ku, Tokyo, 113-8655, Japan. m-akanuma@asahi-life.or.jp.
Masao
M
Akanuma
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Yokohama, Japan. smaeda@yokohama-cu.ac.jp.
Shin
S
Maeda
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. yamaji-tky@umin.ac.jp.
Yutaka
Y
Yamaji
The Institute for Adult Diseases, Asahi Life Foundation, 2-2-6 Bakuro-cho, Nihon-Bashi, Chuo-ku, Tokyo, 113-8655, Japan. y-iwamoto@asahi-life.or.jp.
Yasuhiko
Y
Iwamoto
The Institute for Adult Diseases, Asahi Life Foundation, 2-2-6 Bakuro-cho, Nihon-Bashi, Chuo-ku, Tokyo, 113-8655, Japan. skawa@asahi-life.or.jp.
Shoji
S
Kawazu
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. kkoike-tky@umin.ac.jp.
Kazuhiko
K
Koike
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D048909:Diabetes Complications / Q000453:epidemiology* / Q000382:microbiology; D003920:Diabetes Mellitus / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology
D000900:Anti-Bacterial Agents