The long-term health impact and potential predictors of cardiopulmonary arrest in patients with childhood-onset psychomotor impairments.
OBJECTIVE
The aim of the study was to understand the long-term health issues and potential predictors of cardiopulmonary arrest (CPA) in patients with severe childhood-onset psychomotor impairments.


METHODS
In this single-center, retrospective observational study, the medical records of 140 patients with severe childhood-onset psychomotor impairments were reviewed. The medical interventions and functional status of patients with a history of CPA (n=22: 14 M/8 F; mean±SD age: 26.6±12.4 years) were compared with age- and sex-matched patients without a history of CPA (n=44: 28 M/16 F; mean±SD age: 26.5±12.3 years).


RESULTS
The prevalence of CPA was 15.7%. The most frequent cause was respiratory issues, and CPA occurred most frequently between 0 and 5 years old. The patients who had a history of CPA were more likely to have required a feeding tube (p=0.0007), tracheostomy (p<0.0001), and ventilator (p=0.002) compared to the non-CPA patients, while the prevalence of tracheostomy or ventilator treatment during early infancy was comparable between both groups. Although statistically non-significant, patients who used antiepileptics or feeding tubes during the neonatal period had higher odds of a future CPA.


CONCLUSIONS
This single-center study indicated that the prevalence of CPA could be high among individuals with severe childhood-onset psychomotor impairments, and patients who experience CPA have more health issues. The potential predictors for a future CPA are young age (0-5 years), respiratory issues, and antiepileptic or feeding tube usage during the neonatal period. These patients may require extra attention in medical managements.
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Kazuo
K
Kubota
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan. Electronic address: ymotohashi@ncnp.go.jp.
Yuko
Y
Shimizu-Motohashi
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Takashi
T
Saito
Medical and Welfare Consultation Unit, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Sonoko
S
Akatsuka
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Eri
E
Takeshita
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Akihiko
A
Ishiyama
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Hirofumi
H
Komaki
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Eiji
E
Nakagawa
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Kenji
K
Sugai
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Masayuki
M
Sasaki
D000328:Adult; D017668:Age of Onset; D005260:Female; D006304:Health Status; D006305:Health Status Indicators; D006323:Heart Arrest / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D011596:Psychomotor Disorders / Q000150:complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
Antiepileptics; CPA; Childhood-onset; Medical intervention; Psychomotor impairments; Respiratory issues