Investigation of Interleukin-1β Polymorphisms in Prostate Cancer.
BACKGROUND
Cytokine-mediated immune and inflammatory responses are considered to play an important role in the pathogenesis of prostate cancer. The present study investigated certain interleukin-1β (IL1β) polymorphisms and their association with prostate cancer.


METHODS
Genotyping of the IL1B-31(rs 1143627 G>A) and IL1B-511(rs 16944 A<G) polymorphisms were performed using real-time polymerase chain reaction for blood samples from a group of patients with prostate cancer (n=71) and controls (n=76).


RESULTS
The frequency of the IL1B-31(rs1143627) AG heterozygote genotype was found to be significantly lower in patients compared to controls (odds ratio=0.648, 95% confidence interval=0.463-0.908; p=0.036). The genotypic frequencies of IL1B-511(rs16944) between prostate cancer patients and controls were statistically significantly different (p=0.001). The frequency of AG genotype for IL1B-511(rs16944) was 0.5-fold lower in patients with prostate cancer than in the controls (odds ratio=0.546; 95% confidence interval=0.377-0.791; p=0.001).


CONCLUSIONS
Our data show that individuals carrying the IL1B-31(rs1143627) and IL1B-511(rs16944) AG genotypes had a decreased risk for developing prostate cancer. Out of all the possible combinations analyzed, IL1B-31(rs1143627) G with IL1B-511(rs16944) G combination had a protective association with prostate cancer.
Department of Urology Faculty of Medicine.
Faruk
F
Yencilek
Department of Urology, Göztepe Education and Research Hospital, Istanbul, Turkey.
Asif
A
Yildirim
Department of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey.
Seda Gulec
SG
Yilmaz
Department of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey.
Emre Murat
EM
Altinkilic
Yeditepe University Hospital, Istanbul, Turkey.
Altay Burak
AB
Dalan
Department of Urology, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.
Yavuz
Y
Bastug
Department of Medical Biology, Faculty of Medicine turgay.isbir@yeditepe.edu.tr tisbir@superonline.com.
Turgay
T
Isbir
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood / Q000235:genetics*; D008297:Male; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D060888:Real-Time Polymerase Chain Reaction
D014408:Biomarkers, Tumor; D053583:Interleukin-1beta
interleukin-1β; polymorphism; prostate cancer