Enhanced Sensitivity for Hydrogen Peroxide Detection: Polydiacetylene Vesicles with Phenylboronic Acid Head Group.
It was recently reported that, besides UV irradiated polymerization, polymerization of diacetylene compounds could also been initiated by radicals generated from enzyme catalyzed hydrogen peroxide (H2O2) decomposition. A new optical sensing method for H2O2 was proposed based on this phenomenon. However, the sensitivity of this method is relatively lower than existed ones. In the present work, phenylboronic acid (PBA) functionalized 10, 12-pentacosadiynoic acid (PDA-PBA) was synthesized and its vesicles were formed successfully as colorimetric sensor for H2O2 detection. It was found that color change during the polymerization of vesicles composed of the PBA modified monomer is much stronger than that of the non-modified one. The response of PDA-PBA vesicles to H2O2 is 16 times more sensitive than that of the PDA. The absorption of PDA-PBA at 650 nm is linearly related to the concentration of H2O2 and a detection limit of ~5 μM could be achieved.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Chen
C
Jia
College of Science, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Jie
J
Tang
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Shengguo
S
Lu
College of Science, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Yuwang
Y
Han
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, People's Republic of China. biotech@njtech.edu.cn.
He
H
Huang
D001897:Boronic Acids / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000032:analysis*; D015394:Molecular Structure; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D001897:Boronic Acids; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene; D006861:Hydrogen Peroxide; C010686:benzeneboronic acid
Hydrogen peroxide; Modification; Phenylboronic acid; Polydiacetylene; UV light; Vesicles