Association of common variations of the E-cadherin with endometriosis.
Endometriosis is a polygenic and multifactorial disease. E-cadherin (CDH1) gene encodes an epithelial cell-cell adhesion glycoprotein that modulates a wide variety of processes, including cell polarization, migration and cancer metastasis. Decreased expression of CDH1 in epithelial cells in peritoneal endometriosis has been reported in advanced stages of endometriotic lesions. We investigated the CDH1 -160C/A and +54C/T variations with susceptibility to endometriosis in an Iranian population. In this case-control study, 149 patients with endometriosis (stages I-IV) and 151 healthy women as controls were included. Genotyping was performed using PCR-RFLP method. A p value of <0.05 was considered statistically significant. The CDH1 + 54TT genotype was significantly lower (p = 0.012; OR = 0.30, 95% CI: 0.12-0.77) in the patients (11.6%) than the control group (26.7%). The CDH1 + 54T allele was significantly lower (p = 0.001; OR = 0.55, 95% CI: 0.38-0.77) in the cases (35.7%) compared with the control group (50.3%). No association was found between CDH1 - 160C/A polymorphism and endometriosis. The CDH1 +54C/T was associated with susceptibility to endometriosis in Iranian population, and +54T allele may have a protective role in progression of endometriosis.
a Reproductive Biotechnology Research Center, Avicenna Research Institute , ACECR , Tehran , Iran .
Kioomars
K
Saliminejad
a Reproductive Biotechnology Research Center, Avicenna Research Institute , ACECR , Tehran , Iran .
Haleh
H
Edalatkhah
a Reproductive Biotechnology Research Center, Avicenna Research Institute , ACECR , Tehran , Iran .
Koorosh
K
Kamali
b Central Research Lab, North Khorasan University of Medical Sciences , Bojnurd , Iran , and.
Toktam
T
Memariani
a Reproductive Biotechnology Research Center, Avicenna Research Institute , ACECR , Tehran , Iran .
Mahbobeh
M
Nasiri
a Reproductive Biotechnology Research Center, Avicenna Research Institute , ACECR , Tehran , Iran .
Mitra
M
Saket
c Genetic Research Center, University of Social Welfare and Rehabilitation Sciences , Tehran , Iran.
Hamid Reza
HR
Khorram Khorshid
D000328:Adult; D000483:Alleles; D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007492:Iran; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D055815:Young Adult
D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins
Association study; E-cadherin; endometriosis; polymorphism