P16 and HPV discordance in metastatic carcinoma of cervical lymph nodes of unknown primary.
The prognostic utility of HPV in oropharyngeal squamous cell carcinoma (OPSCC) and non-OPSCC as has been well documented. Currently, a standardized IHC scoring system does not exist and is needed to define HPV positivity. We have recently seen a patient that provides a caution in using p16 status as a diagnostic aid.
Department of Medicine, Advocate Lutheran General Hospital Park Ridge, Chicago, Illinois, 60068, USA.
Alyssa
A
Ralph
Division of Hematology and Oncology, Advocate Lutheran General Hospital Park Ridge, Chicago, Illinois, 60068, USA.
Andrew
A
Meyer
Division of Pathology, Advocate Lutheran General Hospital Park Ridge, Chicago, Illinois, 60068, USA.
Ronald
R
Sirota
Division of Hematology and Oncology, Advocate Lutheran General Hospital Park Ridge, Chicago, Illinois, 60068, USA.
Arthur
A
Hooberman
HPV; Oropharyngeal squamous cell carcinoma; P16; Unknown primary