Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients.
The oxidative stress state is characterized by an increase in oxygen reactive species that overwhelms the antioxidant defense; we do not know if these pathological changes are correlated with alterations in left ventricular mechanics. The aim was correlating the oxidative stress state with the left ventricular global longitudinal strain (GLS) and the left ventricular end diastolic pressure (LVEDP). Twenty-five patients with essential hypertension and 25 controls paired by age and gender were studied. All of the participants were subjected to echocardiography and biochemical determination of oxidative stress markers. The hypertensive patients, compared with control subjects, had significantly (p < 0.05) higher levels of oxidized proteins (5.03 ± 1.05 versus 4.06 ± 0.63 nmol/mg), lower levels of extracellular superoxide dismutase (EC-SOD) activity (0.045 ± 0.02 versus 0.082 ± 0.02 U/mg), higher LVEDP (16.2 ± 4.5 versus 11.3 ± 1.6 mm Hg), and lower GLS (-12% versus -16%). Both groups had preserved ejection fraction and the results showed a positive correlation of oxidized proteins with GLS (r = 0.386, p = 0.006) and LVEDP (r = 0.389, p = 0.005); we also found a negative correlation of EC-SOD activity with GLS (r = -0.404, p = 0.004) and LVEDP (r = -0.347, p = 0.014).
UMAE Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, 06720 Mexico City, DF, Mexico.
Luis Antonio
LA
Moreno-Ruíz
UMAE Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, 06720 Mexico City, DF, Mexico.
David
D
Ibarra-Quevedo
Departamento de Fisiología, Facultad de Medicina, UNAM, 04510 Mexico City, DF, Mexico.
Erika
E
Rodríguez-Martínez
Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, 14269 Mexico City, DF, Mexico.
Perla D
PD
Maldonado
UMAE Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, 06720 Mexico City, DF, Mexico.
Benito
B
Sarabia-Ortega
UMAE Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, 06720 Mexico City, DF, Mexico.
José Gustavo
JG
Hernández-Martínez
UMAE Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, 06720 Mexico City, DF, Mexico.
Beda
B
Espinosa-Caleti
UMAE Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, 06720 Mexico City, DF, Mexico.
Beatriz
B
Mendoza-Pérez
Departamento de Fisiología, Facultad de Medicina, UNAM, 04510 Mexico City, DF, Mexico.
Selva
S
Rivas-Arancibia
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D000075222:Essential Hypertension; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology
D013482:Superoxide Dismutase