Potassium and Its Discontents: New Insight, New Treatments.
Hyperkalemia is common in patients with impaired kidney function or who take drugs that inhibit the renin-angiotensin-aldosterone axis. During the past decade, substantial advances in understanding how the body controls potassium excretion have been made, which may lead to improved standard of care for these patients. Renal potassium disposition is primarily handled by a short segment of the nephron, comprising part of the distal convoluted tubule and the connecting tubule, and regulation results from the interplay between aldosterone and plasma potassium. When dietary potassium intake and plasma potassium are low, the electroneutral sodium chloride cotransporter is activated, leading to salt retention. This effect limits sodium delivery to potassium secretory segments, limiting potassium losses. In contrast, when dietary potassium intake is high, aldosterone is stimulated. Simultaneously, potassium inhibits the sodium chloride cotransporter. Because more sodium is then delivered to potassium secretory segments, primed by aldosterone, kaliuresis results. When these processes are disrupted, hyperkalemia results. Recently, new agents capable of removing potassium from the body and treating hyperkalemia have been tested in clinical trials. This development suggests that more effective and safer approaches to the prevention and treatment of hyperkalemia may be on the horizon.
Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon; Renal Section, Veterans Affairs Portland Health Care System, Portland, Oregon; and ellisond@ohsu.edu.
David H
DH
Ellison
Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon;
Andrew S
AS
Terker
Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Tlalpan, Mexico City, Mexico.
Gerardo
G
Gamba
D006801:Humans; D006947:Hyperkalemia / Q000188:drug therapy* / Q000209:etiology; D007668:Kidney / Q000378:metabolism; D011188:Potassium / Q000378:metabolism
D011188:Potassium
K channels; ion channel; ion transport