Keeping Off the Weight with DCs.
Long studied as modulators of insulin sensitivity, adipose tissue immune cells have recently been implicated in regulating fat mass and weight gain. In this issue of Immunity, Reisner and colleagues (2015) report that ablation of perforin-expressing dendritic cells induces T cell expansion, worsening autoimmunity and surprisingly increasing adiposity.
Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA.
Ethan A
EA
Edwin
Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA. Electronic address: awf7@cumc.columbia.edu.
Anthony W
AW
Ferrante
D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D007249:Inflammation / Q000276:immunology*; D008297:Male; D024821:Metabolic Syndrome / Q000276:immunology*; D052899:Pore Forming Cytotoxic Proteins / Q000032:analysis*
D052899:Pore Forming Cytotoxic Proteins