A water-stable metal-organic framework of a zwitterionic carboxylate with dysprosium: a sensing platform for Ebolavirus RNA sequences.
We herein report a water-stable 3D dysprosium-based metal-organic framework (MOF) that can non-covalently interact with probe ss-DNA. The formed system can serve as an effective fluorescence sensing platform for the detection of complementary Ebolavirus RNA sequences with the detection limit of 160 pM.
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. jxchen@smu.edu.cn whchen@smu.edu.cn.
Liang
L
Qin
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. jxchen@smu.edu.cn whchen@smu.edu.cn.
Li-Xian
LX
Lin
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. jxchen@smu.edu.cn whchen@smu.edu.cn.
Zhi-Ping
ZP
Fang
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. jxchen@smu.edu.cn whchen@smu.edu.cn.
Shui-Ping
SP
Yang
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. jxchen@smu.edu.cn whchen@smu.edu.cn.
Gui-Hua
GH
Qiu
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. jxchen@smu.edu.cn whchen@smu.edu.cn.
Jin-Xiang
JX
Chen
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. jxchen@smu.edu.cn whchen@smu.edu.cn.
Wen-Hua
WH
Chen
D001483:Base Sequence; D018360:Crystallography, X-Ray; D015342:DNA Probes / Q000737:chemistry / Q000235:genetics; D004419:Dysprosium / Q000737:chemistry*; D029043:Ebolavirus / Q000235:genetics / Q000302:isolation & purification*; D005456:Fluorescent Dyes / Q000737:chemistry*; D019142:Hemorrhagic Fever, Ebola / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D057230:Limit of Detection; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*; D012367:RNA, Viral / Q000032:analysis* / Q000235:genetics; D013050:Spectrometry, Fluorescence / Q000379:methods; D014867:Water / Q000737:chemistry
D015342:DNA Probes; D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D012367:RNA, Viral; D014867:Water; D004419:Dysprosium