Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study.
BACKGROUND
Resveratrol may play a protective role against the frailty syndrome (FS) because of its antioxidant and anti-inflammatory properties.


OBJECTIVE
We prospectively evaluated the association between habitual dietary resveratrol exposure and the development of FS after 3-, 6-, and 9-y follow-up periods in a community-dwelling older population.


METHODS
We conducted a longitudinal analysis with the use of data from 769 participants aged ≥65 y from the Invecchiare in Chianti (Aging in Chianti) study. Total dietary resveratrol (TDR) intake was estimated at baseline with the use of a validated food-frequency questionnaire, which was developed to assess participants' usual food intakes over the previous year, and an ad hoc resveratrol database. Total urinary resveratrol (TUR) was analyzed with the use of liquid chromatography-tandem mass spectrometry with a previous solid-phase extraction at baseline. The combination of both measures [total dietary resveratrol plus total urinary resveratrol (TDR+TUR)] was computed with the use of the Howe's method. FS was assessed at baseline and at 3-, 6-, and 9-y of follow-up and was defined as the presence of ≥3 of the following 5 criteria: shrinking, exhaustion, sedentariness, slowness, and weakness.


RESULTS
TDR+TUR concentrations were inversely associated with FS risk over 3-y of follow-up (OR for comparison of extreme tertiles: 0.11; 95% CI: 0.03, 0.45; P-trend = 0.002) but not after 6- and 9-y of follow-up in multinomial logistic regression models adjusted for baseline frailty status and potential confounders. These results did not differ when analyses were further adjusted for inflammatory markers.


CONCLUSIONS
Higher habitual dietary resveratrol exposure was associated with lower risk of older community dwellers developing FS during the first 3 y of follow-up but not after longer follow-up periods.
Biomarkers and Nutrimetabolomics Laboratory, Nutrition and Food Science Department, Catalonian Reference Network on Food Technology (XaRTA), Institute for Research on Nutrition and Food Safety (INSA-UB), Campus Torribera, Pharmacy and Food Sciences Faculty, University of Barcelona, Barcelona, Spain;
Montserrat
M
Rabassa
Biomarkers Group, Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC), Lyon, France;
Raul
R
Zamora-Ros
Biomarkers and Nutrimetabolomics Laboratory, Nutrition and Food Science Department, Catalonian Reference Network on Food Technology (XaRTA), Institute for Research on Nutrition and Food Safety (INSA-UB), Campus Torribera, Pharmacy and Food Sciences Faculty, University of Barcelona, Barcelona, Spain;
Mireia
M
Urpi-Sarda
Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Florence, Italy;
Stefania
S
Bandinelli
Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD; and.
Luigi
L
Ferrucci
Biomarkers and Nutrimetabolomics Laboratory, Nutrition and Food Science Department, Catalonian Reference Network on Food Technology (XaRTA), Institute for Research on Nutrition and Food Safety (INSA-UB), Campus Torribera, Pharmacy and Food Sciences Faculty, University of Barcelona, Barcelona, Spain; candres@ub.edu.
Cristina
C
Andres-Lacueva
Geriatrics and Geriatric Emergency Care, Italian National Research Centre on Aging, Ancona, Italy.
Antonio
A
Cherubini
D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use / Q000652:urine; D000975:Antioxidants / Q000032:analysis / Q000627:therapeutic use*; D015415:Biomarkers / Q000652:urine; D015331:Cohort Studies; D004032:Diet / Q000208:ethnology; D058620:Elder Nutritional Physiological Phenomena / Q000208:ethnology; D005221:Fatigue / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control* / Q000652:urine; D005247:Feeding Behavior / Q000208:ethnology; D005260:Female; D016330:Frail Elderly; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D018908:Muscle Weakness / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control* / Q000652:urine; D011446:Prospective Studies; D012042:Registries; D000077185:Resveratrol; D012307:Risk Factors; D013267:Stilbenes / Q000627:therapeutic use* / Q000652:urine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D015415:Biomarkers; D013267:Stilbenes; D000077185:Resveratrol
InCHIANTI; aging; biomarker; diet; epidemiology; frailty; resveratrol