The role of Eph receptors and Ephrins in the skin.
Eph receptors and Ephrin ligands are widely expressed in the skin. Various studies have been carried out to identify the effects of these molecules on many aspects of skin development. Here we summarize the literature that has identified roles for Eph receptors and Ephrins in the skin, focusing mainly on the epidermis, hair follicles, and cutaneous innervation. This review may help direct and focus further investigations into the role of Eph receptors and Ephrins in the development, maintenance, and repair processes in cutaneous biology.
Burn Injury Research Unit, School of Surgery, University of Western Australia, Perth, WA, Australia.
Dulharie T
DT
Wijeratne
Experimental and Regenerative Neurosciences, School of Animal Biology, University of Western Australia, Perth, WA, Australia.
Jennifer
J
Rodger
Burn Injury Research Unit, School of Surgery, University of Western Australia, Perth, WA, Australia.|The Fiona Wood Foundation, Perth, WA, Australia.
Fiona M
FM
Wood
Burn Injury Research Unit, School of Surgery, University of Western Australia, Perth, WA, Australia.|The Fiona Wood Foundation, Perth, WA, Australia.
Mark W
MW
Fear
D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation; D036342:Ephrins / Q000378:metabolism*; D004817:Epidermis / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000201:enzymology / Q000502:physiology; D006801:Humans; D008297:Male; D036081:Receptors, Eph Family / Q000378:metabolism*; D012680:Sensitivity and Specificity; D015398:Signal Transduction / Q000502:physiology; D012871:Skin Diseases / Q000378:metabolism / Q000503:physiopathology; D012878:Skin Neoplasms / Q000201:enzymology / Q000503:physiopathology*
D015415:Biomarkers; D036342:Ephrins; D036081:Receptors, Eph Family