How PI3K-derived lipids control cell division.
To succeed in cell division, intense cytoskeletal and membrane remodeling are required to allow accurate chromosome segregation and cytoplasm partitioning. Spatial restriction of the actin dynamics and vesicle trafficking define the cell symmetry and equivalent membrane scission events, respectively. Protein complexes coordinating mitosis are recruited to membrane microdomains characterized by the presence of the phosphatidylinositol lipid members (PtdIns), like PtdIns(3,4,5)P 3,PtdIns(4,5)P 2, and PtdIns(3)P. These PtdIns represent a minor component of cell membranes, defining membrane domain identity, ultimately controlling cytoskeleton and membrane dynamics during mitosis. The coordinated presence of PtdIns(3,4,5)P 3 at the cell poles and PtdIns(4,5)P 2 at the cleavage furrow controls the polarity of the actin cytoskeleton leading to symmetrical cell division. In the endosomal compartment, the trafficking of PtdIns(3)P positive vesicles allows the recruitment of the protein machinery required for the abscission.
Department of Molecular Biotechnology and Health Sciences, University of Turin Torino, Italy.
Carlo C
CC
Campa
Department of Molecular Biotechnology and Health Sciences, University of Turin Torino, Italy.
Miriam
M
Martini
Department of Molecular Biotechnology and Health Sciences, University of Turin Torino, Italy.
Maria C
MC
De Santis
Department of Molecular Biotechnology and Health Sciences, University of Turin Torino, Italy.
Emilio
E
Hirsch
GTPases; PI3 kinase; cell division; cytoskeleton dynamics; phosphoinositides; trafficking