Association of sexually transmitted infections, Candida species, gram-positive flora and perianal flora with bacterial vaginosis.
Bacterial vaginosis (BV) is characterised by depletion of the normal Lactobacillus spp. and overgrowth of commensal anaerobic bacteria. We investigated the composition of vaginal microbiota and their association with BV in women of reproductive age. Vaginal samples from 1197 women were analysed, whereby n=451 patients had normal flora and n=614 were diagnosed with BV, the remaining patients were diagnosed with having either intermediate flora (n=42) or dysbacteriosis (n=90). The reported results show that pathogens are associated with BV. This knowledge will further expand our understanding of events leading to BV, which may lead to more effective prevention and treatment strategies.
Molecular Diagnostic Laboratory, Atal-Medial Medical Diagnostic Centre, Amsterdam, Netherlands.
Ali
A
Vahidnia
Molecular Diagnostic Laboratory, Atal-Medial Medical Diagnostic Centre, Amsterdam, Netherlands.
Hellen
H
Tuin
Medical Microbiology Laboratory, Atal-Medial Medical Diagnostic Centre, Amsterdam, Netherlands.
Harry
H
Bliekendaal
Medical Microbiology Laboratory, Atal-Medial Medical Diagnostic Centre, Amsterdam, Netherlands.
Joke
J
Spaargaren
D000293:Adolescent; D000328:Adult; D002175:Candida / Q000145:classification / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D003430:Cross-Sectional Studies; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006094:Gram-Positive Bacteria / Q000145:classification / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D006801:Humans; D064307:Microbiota; D012749:Sexually Transmitted Diseases / Q000382:microbiology*; D014621:Vagina / Q000382:microbiology; D016585:Vaginosis, Bacterial / Q000382:microbiology*; D055815:Young Adult
Bacterial vaginosis; Epidemiology; Nucleic acid amplification tests; Perianal flora; Sexually transmitted infections