A Metal-free Approach to 3-Aryl-3-hydroxy-2-oxindoles by Treatment of 3-Acyloxy-2-oxindoles with Diaryliodonium Salts.
A mild, metal-free approach has been realized for the facile construction of highly valuable 3-(hetero)aryl-3-hydroxy-2-oxindoles. Direct arylations of 3-acyloxy-2-oxindoles with diaryliodonium salts as arylation reagents are implemented in the presence of K2 CO3 at room temperature without using an organometallic promoter to deliver an array of 3-(hetero)aryl-3-hydroxy-2-oxindoles in good yields.
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Xiaokang
X
Li
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Wei
W
Ni
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Fei
F
Mao
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China. wwang@unm.edu.|Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM, 87131-0001, USA. wwang@unm.edu.
Wei
W
Wang
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China. jianli@ecust.edu.cn.
Jian
J
Li
D001713:Biphenyl Compounds / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*
D001713:Biphenyl Compounds; D007211:Indoles; D009861:Onium Compounds
3-acyloxy-2-oxindoles; 3-aryl-3-hydroxy-2-oxindole; arylation; diaryliodonium salt; metal-free