Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease.
We present a test-retest dataset of resting-state fMRI data obtained in 80 cognitively normal elderly volunteers enrolled in the "Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer's Disease" (PREVENT-AD) Cohort. Subjects with a family history of Alzheimer's disease in first-degree relatives were recruited as part of an on-going double blind randomized clinical trial of Naproxen or placebo. Two pairs of scans were acquired ~3 months apart, allowing the assessment of both intra- and inter-session reliability, with the possible caveat of treatment effects as a source of inter-session variation. Using the NeuroImaging Analysis Kit (NIAK), we report on the standard quality of co-registration and motion parameters of the data, and assess their validity based on the spatial distribution of seed-based connectivity maps as well as intra- and inter-session reliability metrics in the default-mode network. This resource, released publicly as sample UM1 of the Consortium for Reliability and Reproducibility (CoRR), will benefit future studies focusing on the preclinical period preceding the appearance of dementia in Alzheimer's disease.
StoP-AD Centre, Centre for Studies on Prevention of Alzheimer's disease, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, 4545 Queen Mary , Montreal, QC H3W 1W5, Canada ; Université de Montréal, 2900 Boulevard Edouard-Montpetit , Montreal, QC H3T 1J4, Canada.
Pierre
P
Orban
StoP-AD Centre, Centre for Studies on Prevention of Alzheimer's disease, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; Douglas Mental Health University Institute Research Centre, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada.
Cécile
C
Madjar
StoP-AD Centre, Centre for Studies on Prevention of Alzheimer's disease, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; Douglas Mental Health University Institute Research Centre, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada.
Mélissa
M
Savard
Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, 4545 Queen Mary , Montreal, QC H3W 1W5, Canada ; Université de Montréal, 2900 Boulevard Edouard-Montpetit , Montreal, QC H3T 1J4, Canada.
Christian
C
Dansereau
StoP-AD Centre, Centre for Studies on Prevention of Alzheimer's disease, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; Douglas Mental Health University Institute Research Centre, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; McGill University, 845 Sherbrooke W , Montreal, QC H3A 0G4, Canada.
Angela
A
Tam
McGill University, 845 Sherbrooke W , Montreal, QC H3A 0G4, Canada ; McConnell Brain Imaging Center, Montreal Neurological Institute, 3801 University , Montreal, QC H3A 2B4, Canada.
Samir
S
Das
McGill University, 845 Sherbrooke W , Montreal, QC H3A 0G4, Canada ; McConnell Brain Imaging Center, Montreal Neurological Institute, 3801 University , Montreal, QC H3A 2B4, Canada.
Alan C
AC
Evans
StoP-AD Centre, Centre for Studies on Prevention of Alzheimer's disease, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; Douglas Mental Health University Institute Research Centre, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; McGill University, 845 Sherbrooke W , Montreal, QC H3A 0G4, Canada ; McGill University Research Centre for Studies in Aging, 6825 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada.
Pedro
P
Rosa-Neto
StoP-AD Centre, Centre for Studies on Prevention of Alzheimer's disease, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; Douglas Mental Health University Institute Research Centre, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; McGill University, 845 Sherbrooke W , Montreal, QC H3A 0G4, Canada.
John C S
JC
Breitner
StoP-AD Centre, Centre for Studies on Prevention of Alzheimer's disease, 6875 LaSalle Boulevard , Montreal, QC H4H 1R3, Canada ; Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, 4545 Queen Mary , Montreal, QC H3W 1W5, Canada ; Université de Montréal, 2900 Boulevard Edouard-Montpetit , Montreal, QC H3T 1J4, Canada.
Pierre
P
Bellec
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D015331:Cohort Studies; D003704:Dementia / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results