Rare and curable renin-mediated hypertension: a series of six cases and a literature review.
BACKGROUND
Reninoma is an extremely rare renal tumor characterized by excessive renin secretion causing secondary hypertension and hypokalemia. Reninoma is a benign and highly manageable lesion if it is discovered early and removed surgically.


METHODS
We report six cases of reninoma and provide a literature review on this rare disease, highlighting the diagnostic evaluation and follow-up of each patient.


CONCLUSIONS
Reninoma should be considered in young adults with elevated renin activity and refractory hypertension. Imaging studies and selective venous catheterization are often helpful in identifying the lesion. In most cases of reninoma presenting with renin-mediated hypertension, conservative surgical treatment should be considered to remove the small, superficial lesion.
Wei-Jun
WJ
Gu
Lin-Xi
LX
Zhang
Nan
N
Jin
Jian-Ming
JM
Ba
Jun
J
Dong
Dian-Jun
DJ
Wang
Jie
J
Li
Xian-Ling
XL
Wang
Guo-Qing
GQ
Yang
Zhao-Hui
ZH
Lu
Jing-Tao
JT
Dou
Ju-Ming
JM
Lu
Yi-Ming
YM
Mu
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D012083:Renin / Q000502:physiology*; D055815:Young Adult
D012083:Renin