Evaluation of maternal serum progranulin levels in normotensive pregnancies, and pregnancies with early- and late-onset preeclampsia.
OBJECTIVE
To investigate the possible pathophysiological associations between progranulin (PGRN) and preeclampsia (PE), early-onset PE (EOPE) and late-onset PE (LOPE).


METHODS
A cross-sectional study was designed to include consecutive patients with uncomplicated pregnancy (n = 28), EOPE (n = 30) and LOPE (n = 22). Maternal levels of serum PGRN were measured with the use of an enzyme-linked immunosorbent assay kit.


RESULTS
The mean serum PGRN level was significantly higher in women with PE compared to the control group (54.17 ± 4.20 pg/ml versus 42.37 ± 5.64 pg/ml, p < 0.001), in the LOPE group compared to the control group (51.63 ± 4.61 pg/ml versus 42.37 ± 5.64 pg/ml, p < 0.001) and also in women with EOPE compared to women with LOPE (56.03 ± 2.68 pg/ml versus 51.63 ± 4.61 pg/ml, p < 0.001). Serum PGRN was negatively correlated with gestational age at birth (r = -0.669, p = 0.001) and birth weight (r = -0.653, p = 0.001); and positively correlated with systolic (r = 0.653, p = 0.001) and diastolic blood pressure (r = 0.601, p = 0.001), C-reactive protein (r = 0.519, p = 0.001), uterine artery pulsatility (r = 0.441, p = 0.001) and resistance indices (r = 0.441, p = 0.001).


CONCLUSIONS
Serum PGRN levels increase significantly in women with PE as an indirect sign of placental dysfunction. This increase is even more prominent in women with EOPE. The serum PGRN in the third trimester is positively correlated with gestational age at birth and birth weight.
a Department of Gynecology and Obstetrics , Cerrahpasa Faculty of Medicine, Istanbul University , Istanbul , Turkey .
Abdullah
A
Serdar Açıkgöz
a Department of Gynecology and Obstetrics , Cerrahpasa Faculty of Medicine, Istanbul University , Istanbul , Turkey .
Abdullah
A
Tüten
a Department of Gynecology and Obstetrics , Cerrahpasa Faculty of Medicine, Istanbul University , Istanbul , Turkey .
Mahmut
M
Öncül
a Department of Gynecology and Obstetrics , Cerrahpasa Faculty of Medicine, Istanbul University , Istanbul , Turkey .
Şerife
Ş
Eskalen
a Department of Gynecology and Obstetrics , Cerrahpasa Faculty of Medicine, Istanbul University , Istanbul , Turkey .
Burcu
B
Çakmak Dinçgez
b Department of General Surgery , Cerrahpasa Faculty of Medicine, Istanbul University , Istanbul , Turkey .
Arife
A
Şimşek
c Sanliurfa Gynecology and Obstetrics Hospital , Sanlıurfa , Turkey , and.
Mehmet
M
Aytaç Yüksel
d Department of Obstetrics and Gynecology , Klinikum Oldenburg University Hospital , Oldenburg , Germany.
Onur
O
Guralp
D000328:Adult; D001724:Birth Weight; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D000077153:Progranulins; D011673:Pulsatile Flow; D055988:Uterine Artery / Q000503:physiopathology
C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins; D002097:C-Reactive Protein
Early-onset preeclampsia; late-onset preeclampsia; progranulin