1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus.
Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3-8) were isolated from the marine-derived Streptomyces spinoverrucosus strain SNB-048. Their structures including the absolute configurations were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Compounds 1 and 2 possess a γ-lactam moiety and a 1,3-oxazin-6-one system.
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas , Dallas, Texas 75390, United States.
Peng
P
Fu
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas , Dallas, Texas 75390, United States.
Scott
S
La
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas , Dallas, Texas 75390, United States.
John B
JB
MacMillan
D007769:Lactams / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification*; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry*
D007769:Lactams; D010078:Oxazines; D011763:Pyrrolizidine Alkaloids; C000609815:spinoxazine A; C000609816:spinoxazine B; C025548:bohemamine