Pathway Distribution Model for Solute Transport in Stratum Corneum.
One of the main functions of the skin is to reduce the amount of water evaporating from the surface of a human body with outermost layer of the epidermis, stratum corneum (SC), forming a barrier, which protects underlying tissue from dehydration. Empirical data obtained for water penetration in SC are normally analysed using mathematical models, among which the homogeneous membrane (HM) model is commonly employed to describe transport kinetics in SC. However, the HM model failed to fit simultaneously the experimental data for water permeation and desorption (Anissimov YG, Roberts MS. 2009. J Pharm Sci 98:772-781), as the model does not account for a complex structure of SC and irregular distribution of corneocytes. Our previous work (Anissimov YG, Roberts MS. 2009. J Pharm Sci 98:772-781) introduced a slow binding (SB) model that is more aligned with the true biological structure of SC. This report provides an alternative/additional model to both the HM and SB models and takes into account the distribution of effective pathways across SC for water transport.
School of Natural Sciences, Griffith University, Nathan, Queensland 4111, Australia; Department of Experimental Physics, Tomsk Polytechnic University, Tomsk 634050, Russian Federation.
Danila G
DG
Petlin
School of Engineering, Griffith University, Southport, Queensland 4222, Australia; Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, Queensland 4111, Australia.
Maksym
M
Rybachuk
School of Natural Sciences, Griffith University, Nathan, Queensland 4111, Australia; Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, Queensland 4111, Australia. Electronic address: y.anissimov@griffith.edu.au.
Yuri G
YG
Anissimov
D001692:Biological Transport / Q000502:physiology*; D004817:Epidermis / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D008962:Models, Theoretical; D010539:Permeability; D012869:Skin Absorption / Q000502:physiology; D012996:Solutions / Q000378:metabolism*; D014867:Water / Q000378:metabolism
D012996:Solutions; D014867:Water
Diffusion; Mathematical model; Percutaneous; Skin; Transdermal; diffusion modelling; pathway distribution; skin reservoir effect; stratum corneum; water transport