Altered neural activation during prepotent response inhibition in breast cancer survivors treated with chemotherapy: an fMRI study.
While impairments in executive functions have been reported in breast cancer survivors (BCS) who have undergone adjuvant chemotherapy, only a limited number of functional neuroimaging studies have associated alterations in cerebral activity with executive functions deficits in BCS. Using fMRI, the current study assessed the neural basis underlying a specific facet of executive function, namely prepotent response inhibition. 12 BCS who self-reported cognitive problems up to 3 years following cancer treatment and 12 female healthy comparisons (HC) performed the Stroop task. We compared their neural activation between the incongruent and neutral experimental conditions. Relative to the HC group, BCS showed lower blood-oxygen level dependent signal in several frontal regions, including the anterior cingulate cortex, a region critical for response inhibition. Our data indicates reduced neural activation in BCS during a prepotent response inhibition task, providing support for the prevailing notion of neural alterations observed in BCS treated with chemotherapy.
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada, V6T 1Z4.
Julia W Y
JW
Kam
Department of Physical Therapy, University of British Columbia, 212, 2177 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3.
Lara A
LA
Boyd
Department of Physical Therapy, University of British Columbia, 212, 2177 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3.|Center for Brain Health, University of British Columbia, Vancouver Coastal Health Research Institute, 2215 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3.
Chun L
CL
Hsu
Department of Physical Therapy, University of British Columbia, 212, 2177 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3.|Center for Brain Health, University of British Columbia, Vancouver Coastal Health Research Institute, 2215 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3.
Teresa
T
Liu-Ambrose
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada, V6T 1Z4.
Todd C
TC
Handy
Department of Medicine, University of British Columbia, 2775 Laurel Street, Vancouver, BC, Canada, V5Z 1M9.|Medical Oncology, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, BC, Canada, V5Z 4E6.
Howard J
HJ
Lim
Department of Medicine, University of British Columbia, 2775 Laurel Street, Vancouver, BC, Canada, V5Z 1M9.
Sherri
S
Hayden
Department of Physical Therapy, University of British Columbia, 212, 2177 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3. kristin.campbell@ubc.ca.
Kristin L
KL
Campbell
D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D001931:Brain Mapping; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D017024:Chemotherapy, Adjuvant; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D056344:Executive Function / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011930:Reaction Time; D057190:Stroop Test; D017741:Survivors; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D010100:Oxygen
Breast cancer survivors; Chemotherapy; Cognitive deficits; Functional MRI; Prepotent response inhibition