Ursodeoxycholic Acid for Treatment of Enlarged Polycystic Liver.
Patients with autosomal dominant polycystic kidney disease and polycystic liver disease (PLD) often have elevated serum levels of alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT). Ursodeoxycholic acid (UDCA) is used to treat biliary tract diseases, but its effect on PLD remains unclear. UDCA was administered for 1 year at a dose of 300 mg daily to seven PLD patients with elevated ALP or GGT levels who were selected for this treatment by experienced clinicians. Laboratory data and liver volumes were compared among three time points: 1 year before UDCA treatment, at the start of UDCA therapy, and 1 year after the start of therapy. Median GGT did not show a significant change between 1 year before UDCA (180 IU/L) and the start of UDCA therapy (209 IU/L), but it decreased significantly to 98 IU/L after 1 year of UDCA therapy (P = 0.015 vs. the start of therapy). ALP showed a significant increase from 1 year before UDCA (456 IU/L) to the start of UDCA therapy (561 IU/L), and then decreased significantly after 1 year of UDCA therapy (364 IU/L). Median liver volume did not show any significant changes among these three time points of assessment. UDCA may be effective for reducing biliary enzyme levels and inhibiting the growth of liver cysts in patients with PLD.
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Takashi
T
Iijima
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Junichi
J
Hoshino
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Tatsuya
T
Suwabe
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Keiichi
K
Sumida
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Koki
K
Mise
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Masahiro
M
Kawada
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Aya
A
Imafuku
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Noriko
N
Hayami
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Rikako
R
Hiramatsu
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Eiko
E
Hasegawa
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.
Naoki
N
Sawa
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.|Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Kajigaya, Japan.
Kenmei
K
Takaichi
Nephrology Center, Toranomon Hospital, Kajigaya, Japan.|Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Kajigaya, Japan.
Yoshifumi
Y
Ubara
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D002756:Cholagogues and Choleretics / Q000008:administration & dosage; D003560:Cysts / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D007690:Polycystic Kidney Diseases / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D006435:Renal Dialysis / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage*; D005723:gamma-Glutamyltransferase / Q000097:blood
D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase
Autosomal dominant polycystic kidney disease; Biliary enzymes; Polycystic liver disease; Ursodeoxycholic acid