Donor-derived tuberculosis after solid organ transplantation in two patients and a staff member.
Because of global mobility and migration resulting in a growing diversity of the donor pool, the risk for donor-derived tuberculosis in solid organ transplant recipients becomes more and more relevant, even in countries with a low overall tuberculosis incidence. Here, we describe a case series of donor-derived tuberculosis in 2 of 3 solid organ transplant recipients and one medical staff member in Germany resulting in the death of one recipient. This case series highlights the relevance of this topic to clinicians. It advocates for a better communication between organ procurement organizations and transplant centers regarding donor information and transplant recipient outcome. Furthermore, it underpins the necessity for a standardized critical incident reporting system in the german transplant system to improve short- and long-term recipient's safety, health and survival.
Department for General, Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital Munich, Campus Großhadern, Ludwig-Maximilian-University Munich, Munich, Germany.
J N
JN
Bucher
Department for General, Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital Munich, Campus Großhadern, Ludwig-Maximilian-University Munich, Munich, Germany. markus.schoenberg@med.uni-muenchen.de.
M B
http://orcid.org/0000-0002-5806-8249
MB
Schoenberg
Department for Anesthesiology, University Hospital Munich, Campus Großhadern, Ludwig-Maximilian-University Munich, Munich, Germany.
I
I
Freytag
Department for General, Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital Leipzig, Leipzig, Germany.
U
U
Lange
Supranational Reference Laboratory of Tuberculosis, IML red GmbH, Gauting, Germany.|Synlab MVZ Gauting, Gauting, Germany.
S
S
Hofmann-Thiel
Department for General, Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital Munich, Campus Großhadern, Ludwig-Maximilian-University Munich, Munich, Germany.
M O
MO
Guba
Department for General, Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital Munich, Campus Großhadern, Ludwig-Maximilian-University Munich, Munich, Germany.
J
J
Werner
Deutsche Stiftung Organtransplantation, Munich, Germany.
A
A
Eder
Department for Anesthesiology, University Hospital Munich, Campus Großhadern, Ludwig-Maximilian-University Munich, Munich, Germany.
G
G
Schelling
Department for General, Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital Munich, Campus Großhadern, Ludwig-Maximilian-University Munich, Munich, Germany.
M
M
Stangl
D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006282:Health Personnel; D006801:Humans; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D014019:Tissue Donors; D066027:Transplant Recipients; D019737:Transplants / Q000382:microbiology*; D014376:Tuberculosis / Q000188:drug therapy / Q000382:microbiology / Q000635:transmission
D000995:Antitubercular Agents
Diagnosis; Health politics; Transplantation; Tuberculosis