Recurrent Rhino-Ocular-Cerebral Mucormycosis in a Leukemic Child: A Case Report and Review of Pediatric Literature.
Mucormycosis is an uncommon but severe fungal infection, typically observed in immunocompromized patients. We report a case of acute lymphoblastic leukemia complicated by rhino-oculo-cerebral mucormycosis in a pediatric patient. Combination lipid polyene-echinocandin therapy, along with surgical debridement appeared to be effective. Nevertheless, a severe relapse occurred during posaconazole prophylaxis; antifungal therapy, hemimaxillectomy and suspension of chemotherapy were performed. Although mucormycosis is a frequently lethal infection, prompt diagnosis and aggressive treatment can be successful even in cases of relapse.
Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Bari , Italy.
Francesco
F
De Leonardis
Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Bari , Italy.
Teresa
T
Perillo
Division of Plastic Surgery, University of Bari , Italy.
Giuseppe
G
Giudice
Division of Otorinolaryngology, University of Bari , Italy.
Gianfranco
G
Favia
Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Bari , Italy.
Nicola
N
Santoro
Mucormycosis; leukemia; pediatrics