[Successful treatment with fondaparinux in heparin-induced thrombocytopenia and thrombosis].
Heparin induced thrombocytopenia (HIT) is an immune-mediated adverse reaction characterized by thrombocytopenia and paradoxical arterial or venous thrombosis, due to the formation IgG antibodies directed to a multimolecular complex of heparin-platelet factor 4 (PF4). Fondaparinux is a selective factor Xa inhibitor with little affinity for PF4 and thus less likely to induce an immune response, making fondaparinux a potentially useful drug for the treatment of HIT. Herein we report the case of a 73 years old woman with HIT associated with arterial and venous thrombosis that was successfully treated with fondaparinux, with normalization of the platelet countand without progression of thrombosis.
Servicio de Clínica Médica, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina. E-mail: cari_seculini@hotmail.com.
Carina E
CE
Seculini Patiño
María Florencia
MF
Pascualini
Aldo H
AH
Tabares
D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D000077425:Fondaparinux; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D009336:Necrosis; D010976:Platelet Count; D010978:Platelet Factor 4 / Q000276:immunology; D011134:Polysaccharides / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000139:chemically induced / Q000188:drug therapy*
D000925:Anticoagulants; D011134:Polysaccharides; D010978:Platelet Factor 4; D006493:Heparin; D000077425:Fondaparinux
anti PF4 antibodies; fondaparinux; heparin induced thrombocytopenia; thrombosis