Visceral adiposity index as a predictor of clinical severity and therapeutic outcome of PCOS.
Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disease which often accompany with abnormal fat distribution. Visceral adiposity has association with abnormal lipid metabolic, pro-inflammatory activity, insulin resistance (IR) and hyperandrogenism. Increased visceral adiposity raises the risk of metabolic syndrome, type 2 diabetes and cardiovascular (CV) events, and aggravates ovulatory dysfunction and hyperandrogenism in PCOS women. Visceral adiposity index (VAI), a simple surrogate maker of visceral adipose dysfunction and visceral adiposity, is a predictor of IR, and link hyperinsulinemia, hyperandrogenism and anovulation. This review aims to discuss the visceral adiposity situation in PCOS women, and suggests that VAI may be a useful predictor of clinical severity and therapeutic outcome of PCOS.
a Department of Gynecology , Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai OB/GYN Hospital, Shanghai Medical College, Fudan University , Shanghai , People's Republic of China.
Sai-Hua
SH
Zheng
a Department of Gynecology , Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai OB/GYN Hospital, Shanghai Medical College, Fudan University , Shanghai , People's Republic of China.
Xue-Lian
XL
Li
D002318:Cardiovascular Diseases / Q000150:complications; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D007249:Inflammation / Q000150:complications; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000503:physiopathology*; D008599:Menstruation Disturbances / Q000209:etiology; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000503:physiopathology*; D012720:Severity of Illness Index
Adipose tissue dysfunction; insulin resistance; polycystic ovary syndrome; visceral adiposity index; visceral obesity