Ionization sources and mass analyzers in MS imaging.
Drug absorption, distribution, metabolism, excretion and toxicology study is one important step in drug discovery and development. MS imaging has become one of the popular methods in this field. Here, selected ionization methods such as matrix-assisted laser desorption/ionization, secondary ion MS and desorption electrospray ionization have been briefly discussed. To differentiate drug and drug metabolites from endogenous compounds present in the biological system, exact mass and/or tandem MS is necessary. As a result, mass analyzers such as time-of-flight, Fourier transform ion cyclotron resonance or Orbitrap are often the method of choice and are briefly introduced.
University of Florida, 1395 Center Dr, Gainesville, FL 32610, USA.
Yu-Hsuan
YH
Tsai
University of Florida, 1395 Center Dr, Gainesville, FL 32610, USA.
Robert F
RF
Menger
University of Florida, 1395 Center Dr, Gainesville, FL 32610, USA.
Dieter M
DM
Drexler
University of Florida, 1395 Center Dr, Gainesville, FL 32610, USA.
Richard A
RA
Yost
University of Florida, 1395 Center Dr, Gainesville, FL 32610, USA.
Timothy J
TJ
Garrett
D005583:Fourier Analysis; D007477:Ions / Q000737:chemistry; D007834:Lasers; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation*
D007477:Ions; D004364:Pharmaceutical Preparations