Bilateral uveal melanomas with different gene expression detected with 7 years interval.
OBJECTIVE
To report a bilateral uveal melanoma detected in a micrometastasis study.


METHODS
Case report.


RESULTS
At enucleation of a circumpapillary amelanotic mixed melanoma in a patient with ocular melanocytosis, a pigmented lesion in the other eye was detected, thought to be a naevus. BAP1 was positive showing nuclear staining of the tumour cells. Seven years later the naevus showed growth and development of a retinal detachment. FNAB disclosed monosomy 3 in the spindle tumour cells.


CONCLUSIONS
A case of bilateral melanoma with long-term survival without metastatic diseases is reported. Different gene expressions in the two eyes were revealed. The case is a reminder that follow-up over years is essential in patients with a uveal melanoma, especially with ocular melanocytosis.
Eye Department, Oslo University Hospital HF, Oslo, Norway.
Nils
N
Eide
Division of Pathology, Oslo University Hospital HF, Oslo, Norway.
Øystein
Ø
Garred
Division of Pathology, Oslo University Hospital HF, Oslo, Norway.
Klaus
K
Beiske
Department of Tumor Biology, Oslo University Hospital HF and University of Oslo, Oslo, Norway.
Øystein
Ø
Fodstad
D000368:Aged; D002830:Choroid Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005451:Fluorescein Angiography; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D018328:Melanoma, Amelanotic / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D008548:Melanosis / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D009006:Monosomy / Q000235:genetics*; D009367:Neoplasm Staging; D009508:Nevus, Pigmented / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D043222:Ubiquitin Thiolesterase / Q000235:genetics*; D014463:Ultrasonography
C400134:BAP1 protein, human; D025521:Tumor Suppressor Proteins; D043222:Ubiquitin Thiolesterase
FISH monosomy-BAP1; bilateral uveal melanoma; melanocytosis; micrometastasis