BEND3 mediates transcriptional repression and heterochromatin organization.
Transcription repression plays a central role in gene regulation. Transcription repressors utilize diverse strategies to mediate transcriptional repression. We have recently demonstrated that BEND3 (BANP, E5R and Nac1 domain) protein represses rDNA transcription by stabilizing a NoRC component. We discuss the role of BEND3 as a global regulator of gene expression and propose a model whereby BEND3 associates with chromatin remodeling complexes to modulate gene expression and heterochromatin organization.
a Department of Cell and Developmental Biology ; University of Illinois at Urbana-Champaign ; Urbana , IL USA.
Abid
A
Khan
a Department of Cell and Developmental Biology ; University of Illinois at Urbana-Champaign ; Urbana , IL USA.
Supriya G
SG
Prasanth
D002460:Cell Line; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D004275:DNA, Ribosomal / Q000378:metabolism; D005786:Gene Expression Regulation; D006570:Heterochromatin / Q000378:metabolism*; D006801:Humans; D012097:Repressor Proteins / Q000378:metabolism*; D014158:Transcription, Genetic
C569909:BEND3 protein, human; D002868:Chromosomal Proteins, Non-Histone; D004275:DNA, Ribosomal; D006570:Heterochromatin; D012097:Repressor Proteins
BEND3; NoRC; NuRD; rDNA; telomeres; transcription repression