[Molecular biology and childhood leukemia: E2A-PBX1 and central nervous system relapse].
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. The inclusion of molecular biology techniques in the diagnosis and prognostic stratification of these patients has allowed major treatment achievements in developed countries. One of the best studied gene rearrangements is E2A-PBX1, which predicts isolated central nervous system relapse in patients with ALL. However, further research on the search for new molecular markers related to prognosis of patients with childhood leukemia is required. Such studies need the integration of different disciplines, including epidemiology. Epidemiological studies are needed not only to accelerate the discovery of new molecular markers and new biological signals as to the etiology and pathophysiology of cancer, but also to evaluate the clinical impact of these findings in well-defined populations.
Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. jcarlos_nu@hotmail.com.
Juan Carlos
JC
Núñez-Enríquez
Juan Manuel
JM
Mejía-Aranguré
D014408:Biomarkers, Tumor / Q000378:metabolism*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D002648:Child; D015321:Gene Rearrangement; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D015514:Oncogene Proteins, Fusion / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000378:metabolism*; D011379:Prognosis; D012008:Recurrence
D014408:Biomarkers, Tumor; D018398:Homeodomain Proteins; D015514:Oncogene Proteins, Fusion; C089847:E2A-Pbx1 fusion protein
Child; Fusion oncogene proteins; Gene rearrangement; Leukemia; Local neoplasm recurrence