Dorsal medial prefrontal cortex contributes to conditioned taste aversion memory consolidation and retrieval.
The medial prefrontal cortex (mPFC) is known for its role in decision making and memory processing, including the participation in the formation of extinction memories. However, little is known regarding its contribution to aversive memory consolidation. Here we demonstrate that neural activity and protein synthesis are required in the dorsal mPFC for memory formation of a conditioned taste aversion (CTA) task and that this region is involved in the retrieval of recent and remote long-term CTA memory. In addition, both NMDA receptor and CaMKII activity in dorsal mPFC are needed for CTA memory consolidation, highlighting the complexity of mPFC functions.
Laboratorio de Memoria, IBCN, UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.
Maria Carolina
MC
Gonzalez
Laboratorio de Memoria, IBCN, UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.
Maria Eugenia
ME
Villar
Grupo de Neurociencias de Sistemas, IFIBIO Houssay, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.
Lionel M
LM
Igaz
Laboratorio de Memoria, IBCN, UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.
Haydée
H
Viola
Laboratorio de Memoria, IBCN, UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina; Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina. Electronic address: jmedina@fmed.uba.ar.
Jorge H
JH
Medina
D000818:Animals; D001596:Benzylamines / Q000008:administration & dosage; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000502:physiology; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D004640:Emetine / Q000008:administration & dosage; D058785:GABA-A Receptor Agonists / Q000008:administration & dosage; D008297:Male; D000069077:Memory Consolidation / Q000187:drug effects / Q000502:physiology*; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology*; D009118:Muscimol / Q000008:administration & dosage; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects; D013449:Sulfonamides / Q000008:administration & dosage; D055697:Taste Perception / Q000187:drug effects / Q000502:physiology*; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000096926:Benzenesulfonamides
D001596:Benzylamines; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D004640:Emetine; D058785:GABA-A Receptor Agonists; D009118:Muscimol; D011500:Protein Synthesis Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate; D013449:Sulfonamides; D014633:Valine; C072105:KN 93; D000096926:Benzenesulfonamides; C056639:2-amino-5-phosphopentanoic acid
APV; Muscimol; NMDA receptor; Neural activity; Protein synthesis