Current approach for detection of sub-clinical left ventricular dysfunction associated with chemotherapy.
The article describes the current knowledge concerning approaches for detection of sub-clinical left ventricular dysfunction associated with chemotherapy. The authors focused on the problem of defining cardiotoxicity as well as diagnostic methods, which may be useful in predicting the occurrence of such complications. Currently, cardiac biomarkers measurement (troponin, NT-proBNP), tissue Doppler-based strain imaging and peak systolic longitudinal strain rate are most useful for detection of early myocardial changes during therapy, whereas speckle tracking echocardiography (STE) and peak systolic global longitudinal strain (GLS) appear to be the best measure. The problem of cardiotoxicity requires close cooperation between oncologists and cardiologists, particularly in light of the growing number of cancer cases.
Poznan University of Medical Sciences, Poznań, Poland.
Katarzyna
K
Korzeniowska
Poznan University of Medical Sciences, Poznań, Poland. Electronic address: jerzyjankowski@wp.pl.
Jerzy
J
Jankowski
Poznan University of Medical Sciences, Poznań, Poland.
Artur
A
Cieślewicz
Poznan University of Medical Sciences, Poznań, Poland.
Anna
A
Jabłecka
D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D003935:Diagnostic Techniques, Cardiovascular; D004452:Echocardiography; D006801:Humans; D062706:Prodromal Symptoms; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology
D000970:Antineoplastic Agents; D015415:Biomarkers
Cardiotoxicity; Echocardiography; Global longitudinal strain; Left ventricular dysfunction; Troponin