Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH.
Absorption of 808 nm laser light by liposomes containing a pH sensitive, near-infrared croconaine rotaxane dye increases dramatically in weak acid. A stealth liposome composition permits acid activated, photothermal heating and also acts as an effective nanoparticle probe for ratiometric photoacoustic imaging of acidic pH in deep sample locations, including a living mouse.
Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, IN 46556, USA. smith.115@nd.edu.
Samit
S
Guha
Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, IN 46556, USA. smith.115@nd.edu.
Gillian Karen
GK
Shaw
Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Trevor M
TM
Mitcham
Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Richard R
RR
Bouchard
Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, IN 46556, USA. smith.115@nd.edu.
Bradley D
BD
Smith
D000143:Acids / Q000737:chemistry; D000818:Animals; D004396:Coloring Agents / Q000737:chemistry*; D006361:Heating; D006863:Hydrogen-Ion Concentration; D008027:Light; D008081:Liposomes / Q000737:chemistry; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D061088:Photoacoustic Techniques / Q000379:methods*; D055668:Photochemical Processes; D043862:Rotaxanes / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000143:Acids; D004396:Coloring Agents; D008081:Liposomes; D043862:Rotaxanes