Optical monitoring of stress-related changes in the brain tissues and vessels associated with hemorrhagic stroke in newborn rats.
Stress is a major factor for a risk of cerebrovascular catastrophes. Studying of mechanisms underlying stress-related brain-injures in neonates is crucial for development of strategy to prevent of neonatal stroke. Here, using a model of sound-stress-induced intracranial hemorrhages in newborn rats and optical methods, we found that cerebral veins are more sensitive to the deleterious effect of stress than arteries and microvessels. The development of venous insufficiency with decreased blood outflow from the brain accompanied by hypoxia, reduction of complexity of venous blood flow and high production of beta-arrestin-1 are possible mechanisms responsible for a risk of neonatal hemorrhagic stroke.
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia ; Huazhong University of Science and Technology, Wuhan 430074, China.
Oxana
O
Semyachkina-Glushkovskaya
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Alexey
A
Pavlov
Huazhong University of Science and Technology, Wuhan 430074, China ; Potsdam Institute for Climate Impact Research, Telegrafenberg A31, 14473 Potsdam, Germany.
Jürgen
J
Kurths
Institute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee 72, Sofia 1784, Bulgaria.
Ekaterina
E
Borisova
Institute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee 72, Sofia 1784, Bulgaria.
Alexander
A
Gisbrecht
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Olga
O
Sindeeva
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Arkady
A
Abdurashitov
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Entusiastov Str.13, Saratov 410049, Russia.
Alexander
A
Shirokov
Saratov State Medical University, Saratov 410010, Russia.
Nikita
N
Navolokin
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Ekaterina
E
Zinchenko
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Artem
A
Gekalyuk
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia.
Maria
M
Ulanova
Huazhong University of Science and Technology, Wuhan 430074, China.
Dan
D
Zhu
Huazhong University of Science and Technology, Wuhan 430074, China.
Qingming
Q
Luo
Saratov State University, Astrakhanskaya Str. 83, Saratov 410012, Russia ; Huazhong University of Science and Technology, Wuhan 430074, China ; Laboratory of Biophotonics, Tomsk State University, Tomsk 634050, Russia.
Valery
V
Tuchin
(170.0170) Medical optics and biotechnology; (170.1470) Blood or tissue constituent monitoring; (170.2655) Functional monitoring and imaging; (170.3880) Medical and biological imaging