Lung protective ventilation and hospital survival of cardiac intensive care patients.
OBJECTIVE
To detect connections between parameters of ventilation and outcomes of cardiac intensive care patients.


METHODS
Noninterventional study. Between 05/11 and 05/12 all patients with acute heart failure and post cardiopulmonary resuscitation were registered. Lung protective ventilation was defined as peak inspiratory pressure (PIP) < 30 mmHg and tidal volume (Vt) < = 6 ml/kg.


RESULTS
In total, 129 patients were included in the study, 68.2 % male, age 67.9 ± 13.4 years, weight 71.4 ± 37.2 kg, predictive body weight 66.9 ± 8.8 kg, mortality 47.3 %. Lung protective ventilated patients at day 1: 17.3 % with a significant difference between surviving and nonsurviving patients (24.1 % vs. 9.6 %; p < 0.05). Logistic regression models showed a strong connection between PIP and survival (odds ratio 1.13; p < 0.05). Vt showed no significant influence on survival.


CONCLUSIONS
Our data recommends a strict observance of a low PIP for cardiac intensive care patients, whereas Vt seems to be of secondary importance.
Department of Medicine III, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany. Michael.Schneck@uk-halle.de.
M
M
Schneck
Department of Medicine III, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany.
K
K
Holder
Department of Medicine III, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany.
S
S
Gielen
Department of Medicine III, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany.
S
S
Nuding
Department of Medicine III, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany.
J
J
Schröder
Department of Medicine III, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany.
A R
AR
Tamm
Department of Medicine III, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany.
K
K
Werdan
Department of Medicine III, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany.
H
H
Ebelt
D000368:Aged; D003422:Critical Care; D005260:Female; D006801:Humans; D008168:Lung; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome; D013990:Tidal Volume
Acute heart failure; Cardiopulmonary resuscitation; Lung protection; Lung protective ventilation; Peak inspiratory pressure; Tidal volume