A novel technique for guided bone regeneration using platelet-rich plasma and osteogenic progenitor cells: Literature-based rationale and case report.
Achieving predictable guided bone regeneration in critical size defects for future endosseous dental implant therapy poses a great challenge to clinicians. A novel technique utilizing autogenous osteogenic progenitor cells, calcium sulfate activated platelet-rich plasma in addition to particulate allograft was successfully used to augment a severely deficient maxillary anterior edentulous ridge. After 6 months of healing, satisfactory radiographic and clinical bone gain was noted with significant increase in alveolar ridge width. Endosseous implants were placed and restored successfully. The techniques with underlying clinical and biologic rationales are presented and discussed in this report.
TaeHyun
T
Kwon
Peter C
PC
Grieco
Liran
L
Levin
Giuseppe
G
Intini
D000328:Adult; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001861:Bone Regeneration / Q000502:physiology*; D016025:Bone Transplantation / Q000379:methods; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008297:Male; D008437:Maxilla / Q000601:surgery; D010012:Osteogenesis / Q000502:physiology*; D010518:Periodontitis / Q000150:complications / Q000628:therapy; D053657:Platelet-Rich Plasma; D013234:Stem Cells / Q000502:physiology*