Sympathetic nerves: How do they affect angiogenesis, particularly during wound healing of soft tissues?
Angiogenesis is essential for wound healing, and angiogenesis impairment can result in chronic ulcers. Studies have shown that the sympathetic nervous system has an important role in angiogenesis. In recent years, researchers have focused on the roles of sympathetic nerves in tumor angiogenesis. In fact, sympathetic nerves can affect angiogenesis in the wound healing of soft tissues, and may have a similar mechanism of action as that seen in tumorigenesis. Sympathetic nerves act primarily through interactions between the neurotransmitters released from nerve endings and receptors present in target organs. Among this, activation or inhibition of adrenergic receptors (mainly β-adrenergic receptors) influence formation of new blood vessels considerably. As sympathetic nerves locate near pericytes in microvessel, go along the capillaries and there are adrenergic receptors present in endothelial cells and pericytes, sympathetic nerves may participate in angiogenesis by influencing the endothelial cells and pericytes of new capillaries. Studying the roles of sympathetic nerves on the angiogenesis of wound healing can contribute to understanding the mechanisms of tissue repair, tissue regeneration, and tumorigenesis, thereby providing new therapeutic perspectives.
Southern Medical University, Guangzhou, China.|Department of Plastic Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
Liangli
L
Pan
Department of Plastic Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
Jianbing
J
Tang
Department of Plastic Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Hongwei
H
Liu
Southern Medical University, Guangzhou, China.|Department of Plastic Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.|Center of Wound Treatment, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.|The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area, PLA, Guangzhou, China.
Biao
B
Cheng
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D001808:Blood Vessels / Q000294:innervation; D002196:Capillaries; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000166:cytology; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D018377:Neurotransmitter Agents / Q000378:metabolism; D020286:Pericytes / Q000166:cytology; D011941:Receptors, Adrenergic / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology*; D014945:Wound Healing
D018377:Neurotransmitter Agents; D011941:Receptors, Adrenergic
Sympathetic nerves; angiogenesis; endothelial cells; pericytes; wound healing