Dementia priority setting partnership with the James Lind Alliance: using patient and public involvement and the evidence base to inform the research agenda.
BACKGROUND
The James Lind Alliance (JLA) created an approach to elicit the views of those under-represented in research priority exercises. Building on this, the JLA Dementia Priority Setting Partnership was set up as an independent and evidence-based project to identify and prioritise unanswered questions ('uncertainties') about prevention, diagnosis, treatment and care relating to dementia.


METHODS
A survey was widely disseminated to stakeholders with an interest in the needs of the older population. Thematic analysis was used to identify themes from the large amount of questions collected from which research questions were developed using PICO framework (Population, Intervention, Comparator, Outcome). Each question was checked against an extensive evidence base of high-quality systematic reviews to verify whether they were true uncertainties.


RESULTS
One thousand five hundred and sixty-three questionnaires were received, from people with dementia, carers/relatives, and health and care professionals; 85 uncertainties were identified from other sources. Questions were refined and formatted iteratively into 146 unique uncertainties. An interim prioritisation process involving diverse organisations identified the top 25 ranked questions. At a final face-to-face prioritisation workshop, 18 people representing the above constituencies arrived by consensus at the top 10 priority questions. The impact of patient and public involvement on the priorities is discussed.


CONCLUSIONS
The long (146 questions) and top 10 lists of dementia research priorities provide a focus for researchers, funders and commissioners. They highlight a need for more research into care for people with dementia and carers, and a need for high-quality effectiveness trials in all aspects of dementia research.
Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SR, UK.
Sarah
S
Kelly
Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SR, UK.
Louise
L
Lafortune
Alzheimer's Society, London, UK.
Nicola
N
Hart
James Lind Alliance, Southampton, UK.
Katherine
K
Cowan
UK Database of Uncertainties about the Effects of Treatment, National Institute for Health Care and Excellence, Manchester, UK.
Mark
M
Fenton
Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SR, UK.
Carol
C
Brayne
D000368:Aged; D035843:Biomedical Research / Q000592:standards; D003704:Dementia / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy*; D004493:Education; D006292:Health Priorities / Q000458:organization & administration / Q000706:statistics & numerical data; D006801:Humans; D011795:Surveys and Questionnaires
James Lind Alliance; PPI; care; carer; dementia; diagnosis; older people; patient and public involvement; prevention; priority setting; public health; survey; treatment