The Hyaluronic Acid Fillers: Current Understanding of the Tissue Device Interface.
The article is a detailed update regarding cosmetic injectable fillers, specifically focusing on hyaluronic acid fillers. Hyaluronic acid-injectable fillers are used extensively for soft tissue volumizing and contouring. Many different hyaluronic acid-injectable fillers are available on the market and differ in terms of hyaluronic acid concentration, particle size, cross-linking density, requisite needle size, duration, stiffness, hydration, presence of lidocaine, type of cross-linking technology, and cost. Hyaluronic acid is a natural component of many soft tissues, is identical across species minimizing immunogenicity has been linked to wound healing and skin regeneration, and is currently actively being studied for tissue engineering purposes. The biomechanical and biochemical effects of HA on the local microenvironment of the injected site are key to its success as a soft tissue filler. Knowledge of the tissue-device interface will help guide the facial practitioner and lead to optimal outcomes for patients.
Department of Otolaryngology - Head and Neck Surgery, Northwestern University, 676 N. St. Clair, Suite 1325, Chicago, IL 60611, USA.
Jacqueline J
JJ
Greene
Department of Otolaryngology - Head and Neck Surgery, Northwestern University, 676 N. St. Clair, Suite 1325, Chicago, IL 60611, USA. Electronic address: dsidle@nm.org.
Douglas M
DM
Sidle
D001672:Biocompatible Materials / Q000627:therapeutic use*; D001707:Biopsy, Needle; D003357:Cosmetic Techniques; D000067548:Dermal Fillers / Q000494:pharmacology / Q000627:therapeutic use*; D004954:Esthetics; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D007150:Immunohistochemistry; D007279:Injections, Subcutaneous; D008297:Male; D061214:Patient Safety; D012060:Rejuvenation / Q000502:physiology; D012867:Skin / Q000187:drug effects / Q000473:pathology; D015595:Skin Aging / Q000187:drug effects*; D023822:Tissue Engineering / Q000379:methods; D014481:United States
D001672:Biocompatible Materials; D000067548:Dermal Fillers; D006820:Hyaluronic Acid
Cosmetic injectables; HA fillers; Hyaluronic acid; Injectable fillers; Tissue device interface