The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease.
OBJECTIVE
The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD.


METHODS
From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation.


RESULTS
The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin -384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35-5.85), p = 0.006; HR (95% CI) 2.63 (1.19-5.83), p = 0.017; eotaxin -384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease.


CONCLUSIONS
The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients.
Department of Internal Medicine/Cardioangiology and ICRC, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekařská 53, 656 91 Brno, Czech Republic.
Vladimír
V
Kincl
Department of Internal Medicine/Cardioangiology and ICRC, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekařská 53, 656 91 Brno, Czech Republic ; Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Jan
J
Máchal
Department of Internal Medicine/Cardioangiology and ICRC, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekařská 53, 656 91 Brno, Czech Republic.
Adéla
A
Drozdová
Department of Internal Medicine/Cardioangiology and ICRC, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekařská 53, 656 91 Brno, Czech Republic.
Roman
R
Panovský
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Anna
A
Vašků
D000368:Aged; D016022:Case-Control Studies; D054413:Chemokine CCL11 / Q000235:genetics*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D053509:Matrix Metalloproteinase 13 / Q000235:genetics*; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D054413:Chemokine CCL11; D052250:Nitric Oxide Synthase Type III; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13