Retinopathy of prematurity: Risk factors and variability in Canadian neonatal intensive care units.
OBJECTIVE
To identify predictors of severe retinopathy of prematurity (ROP) in a large population-based cohort and to examine risk-adjusted variations across units.


METHODS
Retrospective analysis of Canadian Neonatal Network data on neonates with birth weight <1500 g who were screened for ROP between 2003 and 2010. Characteristics of infants with and without ROP were compared and a risk-adjusted model for severe ROP was developed. Rates of severe ROP were compared between sites.


RESULTS
1163 of 9187 (12.7%) infants developed severe ROP. Lower gestational age, male sex, small for gestational age, patent ductus arteriosus, late onset sepsis, more than two blood transfusions, inotrope use, and outborn status were associated with an increased risk of severe ROP. Severe ROP rates varied significantly between units.


CONCLUSIONS
Younger, smaller and sicker male infants had higher adjusted risks of severe ROP and rates varied significantly among sites.
Department of Pediatrics, Kingston General Hospital, Kingston, Ontario, Canada.
K
K
Thomas
Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
P S
PS
Shah
Department of Pediatrics, Moncton Hospital, Moncton, New Brunswick, Canada.
R
R
Canning
Department of Pediatrics, Victoria General Hospital, Victoria, British Columbia, Canada.
A
A
Harrison
Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
S K
SK
Lee
Department of Pediatrics, Kingston General Hospital, Kingston, Ontario, Canada.
K E
KE
Dow
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002170:Canada / Q000453:epidemiology; D015331:Cohort Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015931:Intensive Care, Neonatal / Q000706:statistics & numerical data*; D008403:Mass Screening / Q000706:statistics & numerical data; D012178:Retinopathy of Prematurity / Q000175:diagnosis* / Q000453:epidemiology* / Q000517:prevention & control; D012189:Retrospective Studies; D012307:Risk Factors
D000900:Anti-Bacterial Agents
Retinopathy of prematurity; incidence; infant; premature