Oral clindamycin causing acute cholestatic hepatitis without ductopenia: a brief review of idiosyncratic drug-induced liver injury and a case report.
Clindamycin is a lincosamide antibiotic active against most of the anaerobes, protozoans, and Gram-positive bacteria, including community-acquired methicillin-resistant Staphylococcus aureus. Its use has increased greatly in the recent past due to wide spectrum of activity and good bioavailability in oral form. Close to 20% of the patients taking clindamycin experience diarrhea as the most common side effect. Hepatotoxicity is a rare side effect. Systemic clindamycin therapy has been linked to two forms of hepatotoxicity: transient serum aminotransferase elevation and an acute idiosyncratic liver injury that occurs 1-3 weeks after starting therapy. This article is a case report of oral clindamycin induced acute symptomatic cholestatic hepatitis and a brief review of the topic.
Division of General Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA; harsha1778@yahoo.co.in.
Harsha
H
Moole
Division of General Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.
Zohair
Z
Ahmed
Division of Pathology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.
Nibha
N
Saxena
Division of Gastroenterology and Hepatology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.
Srinivas R
SR
Puli
Division of Gastroenterology and Hepatology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.
Sonu
S
Dhillon
acute cholestatic hepatitis; acute liver failure; clindamycin; drug-induced liver injury; hepatotoxicity