[Potential Mechanisms Underlying Acupuncture Regulation on Hypertensive Myocardial Hypertrophy and Cardiac Function Damage].
Long-lasting hypertension results in ventricular remodeling characteristic of myocardial hypertrophy including myocyte hypertrophy and myocardial fibrosis, a pathological process failed to be blocked by the current biomedical means and could eventually lead to heart failure. It has been shown that acupuncture can excite the parasympathetic nerve to counter the overtonic activity of sympathetic nerve, elicit antihypertensive effect and produce cardioprotection via the regulation of calcium signaling-related proteins in myocytes, suggesting its potential role in the management of these disorders. In this paper, the authors review relevant studies and propose, with respect to the autonomic nerve, endocrine system, cytokines and intracellular calcium signaling pathways, several novel ideas concerning the treatment of hypertensive myocardial hypertrophy and cardiac malfunction by acupuncture.
Juan-juan
JJ
Xin
Jun-hong
JH
Gao
Feng-yan
FY
Lu
Yu-xue
YX
Zhao
Xiang-hong
XH
Jing
Xiao-chun
XC
Yu
D015670:Acupuncture Therapy; D006332:Cardiomegaly / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*