A Highly Similar Mathematical Model for Cerebral Blood Flow Velocity in Geriatric Patients with Suspected Cerebrovascular Disease.
Cerebral blood flow velocity(CBFV) is an important parameter for study of cerebral hemodynamics. However, a simple and highly similar mathematical model has not yet been established for analyzing CBFV. To alleviate this issue, through TCD examination in 100 geriatric patients with suspected cerebrovascular disease (46 males and 54 females), we established a representative eighth-order Fourier function Vx(t) that simulates the CBFV. The measured TCD waveforms were compared to those derived from Vx(t), an illustrative Kolmogorov-Smirnov test was employed to determine the validity. The results showed that the TCD waves could been reconstructed for patients with different CBFVs by implementing their variable heart rates and the formulated maximum/minimum of Vx(t). Comparisons between derived and measured TCD waveforms suggest that the two waveforms are very similar. The results confirm that CBFV can be well-modeled through an eighth-order Fourier function. This function Vx(t) can be used extensively for a prospective study of cerebral hemodynamics in geriatric patients with suspected cerebrovascular disease.
Department of Neurology, The Third Hospital of Mianyang, Mianyang, Sichuan 621000, China.|Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China.|Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China.|Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.
Bo
B
Liu
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.|Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China.|Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.
Qi
Q
Li
Department of Neurology, The Third Hospital of Mianyang, Mianyang, Sichuan 621000, China.
Jisheng
J
Wang
Department of Neurology, The Third Hospital of Mianyang, Mianyang, Sichuan 621000, China.
Hu
H
Xiang
Department of Neurology, The Third Hospital of Mianyang, Mianyang, Sichuan 621000, China.
Hong
H
Ge
Department of Neurology, The Third Hospital of Mianyang, Mianyang, Sichuan 621000, China.
Hui
H
Wang
Department of Neurology, The Third Hospital of Mianyang, Mianyang, Sichuan 621000, China.|Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China.|Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.|Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China.|Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.
Peng
P
Xie
D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000502:physiology*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D017585:Ultrasonography, Doppler, Transcranial