Moderate exercise training attenuates aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts.
Aging is the most important risk factor in cardiovascular disease (CVD), which is the leading causes of death worldwide and the second major cause of death in Taiwan. The major factor in heart failure during aging is heart remodeling, including long-term stress-induced cardiac hypertrophy and fibrosis. Exercise is good for aging heart health, but the impact of exercise training on aging is not defined. This study used 3-, 12- and 18-month-old rats and randomly divided each age group into no exercise training control groups (C3, A12 and A18) and moderate gentle swimming exercise training groups (E3, AE12 and AE18). The protocol of exercise training was swimming five times weekly with gradual increases from the first week from 20 to 60 min for 12 weeks. Analyses of protein from rat heart tissues and sections revealed cardiac inflammation, hypertrophy and fibrosis pathway increases in aged rat groups (A12 and A18), which were improved in exercise training groups (AE12 and AE18). There were no heart injuries in young rat hearts in exercise group E3. These data suggest that moderate swimming exercise training attenuated aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts.
Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Po-Hsiang
PH
Liao
School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Dennis Jine-Yuan
DJ
Hsieh
Laboratory of Exercise Biochemistry, Department of Sports Sciences, University of Taipei, Taipei, Taiwan.
Chia-Hua
CH
Kuo
Department of Nursing, Mei Ho University, Pingguang Road, Pingtung, Taiwan.
Cecilia-Hsuan
CH
Day
Department of Nursing, Mei Ho University, Pingguang Road, Pingtung, Taiwan.
Chia-Yao
CY
Shen
Division of Cardiology, Department of Internal Medicine, Armed Force Taichung General Hospital, Taichung, Taiwan.
Chao-Hung
CH
Lai
Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ray-Jade
RJ
Chen
Department of Biotechnology, Bharathiar University, Coimbatore, India.
V Vijaya
VV
Padma
Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Wei-Wen
WW
Kuo
Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.|Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.|Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
Chih-Yang
CY
Huang
D000367:Age Factors; D000818:Animals; D006332:Cardiomegaly / Q000473:pathology*; D005355:Fibrosis; D006333:Heart Failure / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D012307:Risk Factors; D015398:Signal Transduction
Gerotarget; aging; cardiovascular disease; heart failure; moderate exercise training