Translocation (1;5) in a Glomus Tumor.
Glomus tumor is a rare perivascular neoplasm that usually occurs in the distal extremities of young adults. Recent molecular studies have identified microRNA 143-NOTCH fusions or NOTCH1-3 rearrangements in benign and malignant glomus tumors. Herein, we describe the cytogenetic and molecular cytogenetic findings of a glomus tumor arising in the left wrist of a 45-year-old man. Physical examination showed a 1.3-cm, blue-red, tender nodule. Magnetic resonance imaging demonstrated a subcutaneous, well-circumscribed mass with low signal intensity on T1-weighted sequences and high signal intensity on T2-weighted sequences. Contrast-enhanced fat-suppressed T1-weighted sequences showed a homogeneous, strong enhancement. A marginal excision was performed and histopathological examination confirmed the diagnosis of a glomus tumor. Cytogenetic and spectral karyotypic analyses showed a novel rearrangement involving chromosome bands 1p13 and 5q32. There has been no evidence of local recurrence four months after surgery. To the best of our knowledge, this is the first case of sporadic glomus tumor with t(1;5).
Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan jnishio@cis.fukuoka-u.ac.jp.
Jun
J
Nishio
Department of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Kazuki
K
Nabeshima
Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Shun
S
Mori
Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Masatoshi
M
Naito
D000328:Adult; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D020732:Cytogenetic Analysis; D005918:Glomus Tumor / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014178:Translocation, Genetic / Q000235:genetics*
Glomus tumor; MIR143; NOTCH2; cytogenetics; t(1;5)