Four pestalpolyols from a mycoparasite Pestalotipsis sp. PG52.
A mycoparasite PG52 isolated from aeciospore piles of Aecidium pourthiaea was identified as Pestalotipsis sp. The chemical constituents of Pestalotipsis sp. PG52 were investigated. Four novel polyketides, named pestalpolyols E-H (1-4), were isolated from solid fermentations of Pestalotiopsis sp. PG52. Their structures were elucidated by interpretation of extensive spectroscopic methods, including 1D and 2D NMR, HR-MS experiments; and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis using the anomalous scattering of Cu Kα radiation. Compounds 2-4 showed cytotoxic activities against human tumor cell lines.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.|Life Science College, Southwest Forestry University, Kunming, 650224, China.
Jin
J
Xie
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.|Life Science College, Southwest Forestry University, Kunming, 650224, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
Jing
J
Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
Yin-He
YH
Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
Xiao-Nian
XN
Li
Life Science College, Southwest Forestry University, Kunming, 650224, China.
Yu-Hui
YH
Chen
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. pjzhao@outlook.com.
Pei-Ji
PJ
Zhao
Cytotoxic activity; Pestalotiopsis sp. PG52; Pestalpolyol; Polyketide