SIRT1 Polymorphisms Associate with Seasonal Weight Variation, Depressive Disorders, and Diastolic Blood Pressure in the General Population.
SIRT1 polymorphisms have previously been associated with depressive and anxiety disorders. We aimed at confirming these earlier findings and extending the analyses to seasonal variations in mood and behavior. Three tag single-nucleotide polymorphisms (SNPs) were selected to capture the common variation in the SIRT1 gene. 5910 individuals (with blood sample, diagnostic interview, self-report of on seasonal changes in mood and behavior) were selected from a representative Finnish nationwide population-based sample. Logistic and linear regression models were used to analyze the associations between the SNPs and depressive and anxiety disorders, metabolic syndrome (EGIR criteria) and its components, and health examination measurements, Homeostasis Model Assessments, and diagnoses of type 2 and type 1 diabetes. SIRT1 rs2273773 showed evidence of association with seasonal variation in weight (C-allele, OR = 0.85, 95% CI = 0.76-0.95, p = 0.005). In addition, our study gave further support for the association of SIRT1 gene with depressive disorders (rs3758391) and diastolic blood pressure (rs2273773).
Department of Health, Mental Health Unit, National Institute for Health and Welfare (THL), Helsinki, Finland.
Leena
L
Kovanen
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Kati
K
Donner
Department of Health, Mental Health Unit, National Institute for Health and Welfare (THL), Helsinki, Finland.
Timo
T
Partonen
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000235:genetics* / Q000502:physiology*; D003866:Depressive Disorder / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012621:Seasons; D056564:Sirtuin 1 / Q000235:genetics*
C447939:SIRT1 protein, human; D056564:Sirtuin 1