Periarticular Injection After Total Knee Arthroplasty Using Liposomal Bupivacaine vs a Modified Ranawat Suspension: A Prospective, Randomized Study.
BACKGROUND
The purpose of this study is to compare liposomal bupivacaine to a modified (Ranawat) local injection for total knee arthroplasty (TKA).


METHODS
This is a prospective, randomized study of 105 consecutive patients undergoing primary TKA. Group A patients received a periarticular injection with liposomal bupivacaine and group B with a mixture of ropivacaine, epinephrine, ketorolac, and clonidine. There were 54 patients in the group A (liposomal bupivacaine) and 51 in group B.


RESULTS
There were no differences in the groups with respect to age, sex, and preoperative knee scores. There were no differences with respect to postoperative narcotic usage and knee range of motion.


CONCLUSIONS
Liposomal bupivacaine as a periarticular injection after TKA demonstrated similar pain levels, narcotic usage, and range of motion compared to a modified Ranawat suspension but improved walking distance.
Department of Orthopaedic Surgery, University of Louisville, Louisville, Kentucky.
Philip N
PN
Collis
Department of Orthopaedic Surgery, University of Louisville, Louisville, Kentucky.
Allison M
AM
Hunter
Department of Orthopaedic Surgery, University of Louisville, Louisville, Kentucky.
Michael D Derek
MD
Vaughn
Norton Leatherman Spine Center, Louisville, Kentucky.
Leah Y
LY
Carreon
Jewish Hospital, Louisville, Kentucky.
Jiapeng
J
Huang
University of Louisville Adult Reconstruction Program, Louisville, Kentucky.
Arthur L
AL
Malkani
D000368:Aged; D000577:Amides / Q000008:administration & dosage; D000700:Analgesics / Q000008:administration & dosage*; D019645:Arthroplasty, Replacement, Knee; D002045:Bupivacaine / Q000008:administration & dosage*; D003000:Clonidine / Q000008:administration & dosage; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007267:Injections; D020910:Ketorolac / Q000008:administration & dosage; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies; D000077212:Ropivacaine
D000577:Amides; D000700:Analgesics; D008081:Liposomes; D000077212:Ropivacaine; D003000:Clonidine; D002045:Bupivacaine; D004837:Epinephrine; D020910:Ketorolac
TKA; liposomal bupivacaine; postop pain; ranawat suspension