Rapid and Efficient Conversion of (11) CO2 to (11) CO through Silacarboxylic Acids: Applications in Pd-Mediated Carbonylations.
Herein, we present a new rapid, efficient, and low-cost radiosynthetic protocol for the conversion of (11) CO2 to (11) CO and its subsequent application in Pd-mediated reactions of importance for PET applications. This room-temperature methodology, using readily available chemical reagents, is carried out in simple glass vials, thus eliminating the need for expensive and specialized high-temperature equipment to access (11) CO. With this fast and near-quantitative conversion of (11) CO2 into (11) CO, aryl and heteroaryl iodides were easily converted into a broad selection of biologically active amides in radiochemical yields ranging from 29-84 %.
Platform for Preclinical PET, Department of Medicinal Chemistry, Uppsala University, P.O Box 574, 751 23, Uppsala (Sweden), Fax: (+46) 184714474.
Patrik
P
Nordeman
Carbon Dioxide Activation Center (CADIAC), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 86196199.
Stig D
SD
Friis
Carbon Dioxide Activation Center (CADIAC), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 86196199.
Thomas L
TL
Andersen
Carbon Dioxide Activation Center (CADIAC), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 86196199.
Hélène
H
Audrain
Science for Life Laboratory, Department of Medicinal Chemistry, BMC, Uppsala University, P.O. Box 574, 751 23 Uppsala (Sweden).
Mats
M
Larhed
Carbon Dioxide Activation Center (CADIAC), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 86196199. ts@chem.au.dk.
Troels
T
Skrydstrup
Platform for Preclinical PET, Department of Medicinal Chemistry, Uppsala University, P.O Box 574, 751 23, Uppsala (Sweden), Fax: (+46) 184714474. gunnar.antoni@pet.medchem.uu.se.
Gunnar
G
Antoni
carbon dioxide fixation; carbon monoxide; carbon-11; positron emission tomography; radiochemistry