Aspergillus Mediastinitis after Orthotopic Heart Transplantation: A Case Report.
A 55-year-old woman was admitted for orthotopic heart transplantation. Her medical history was notable for multiple cardiovascular problems, including ischemic cardiomyopathy that necessitated circulatory support with a left ventricular assist device. Five weeks after undergoing orthotopic heart transplantation, she developed Aspergillus calidoustus mediastinitis, for which she underwent a prolonged course of antifungal treatment that comprised (in sequence) posaconazole for 11 days, voriconazole for 10 days, and amphotericin B for 42 days. During this period, she also underwent repeated mediastinal drainage and sternal débridement, followed by sternal wiring and coverage with bilateral pectoralis advancement flaps. Four months postoperatively, she was discharged from the hospital with a successfully controlled infection and a healed sternum. To our knowledge, only 3 previous cases of Aspergillus mediastinitis after orthotopic heart transplantation have been reported in the literature, none of which was Aspergillus calidoustus.
Magdy M
MM
El-Sayed Ahmed
Abdelkader
A
Almanfi
Muhammad
M
Aftab
Steve K
SK
Singh
Hari R
HR
Mallidi
O H
OH
Frazier
D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001228:Aspergillosis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D001230:Aspergillus / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D003131:Combined Modality Therapy; D003646:Debridement; D004322:Drainage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008480:Mediastinitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D008875:Middle Aged; D012086:Reoperation; D013524:Surgical Flaps; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage; D065819:Voriconazole / Q000008:administration & dosage
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B; D065819:Voriconazole
Amphotericin B/therapeutic use; Aspergillus calidoustus; antifungal agents; aspergillosis/therapy; heart transplantation, orthotopic; mediastinitis, postoperative; surgical wound infection/complications