Adult-onset Kawasaki disease (mucocutaneous lymph node syndrome) and concurrent Coxsackievirus A4 infection: a case report.
BACKGROUND
Kawasaki disease (KD) most commonly develops in infants, although its specific cause is still unclear. We report here a rare case of adult-onset KD which revealed to be concurrently infected by Coxsackievirus A4.


METHODS
The patient was a 37-year-old Japanese man who presented with fever, exanthema, changes in the peripheral extremities, bilateral non-exudative conjunctival injection, and changes in the oropharynx, signs that meet the diagnostic criteria for KD defined by the Centers for Disease Control and Prevention. In this case, the patient had a significantly high antibody titer for Coxsackievirus A4, which led us to presume that the occurrence of KD was concurrent Coxsackievirus A4 infection.


CONCLUSIONS
We reported a very rare case of KD which suggests that the disease can be concurrent Coxsackievirus A4 infection. Although KD is an acute childhood disease, with fever as one of the principal features, KD should also be considered in the differential diagnosis when adult patients present with a fever of unknown cause associated with a rash.
Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Japan.
Yuki
Y
Ueda
Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Japan ; Division of Community Medicine and Career Development, Kobe University Graduate School of Medicine, Japan.
Tsuneaki
T
Kenzaka
Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Japan.
Ayako
A
Noda
Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Japan.
Yu
Y
Yamamoto
Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Japan.
Masami
M
Matsumura
Coxsackievirus A4; Kawasaki disease; adult-onset; mucocutaneous lymph node syndrome; skin rash