Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population.
OBJECTIVE
To investigate whether the apurinic/apyrimidinic endonuclease 1 (APE1) 1349 T>G and -656 T>G polymorphisms were associated with the risk of noise-induced hearing loss (NIHL) in a Chinese population.


METHODS
The two APE1 polymorphisms were analyzed among 613 NIHL workers and 613 normal hearing workers using the minor groove binder TaqMan probe assay.


RESULTS
We found that the APE1 -656 TT genotype was associated with a increased risk of NIHL [adjusted odds ratio (OR) 1.46, 95% confidence interval (CI) 1.05-2.06]. This increased risk was more pronounced in the stratification analysis. Furthermore, we found that subjects with two risk genotypes (hOGG1 Cys/Cys, APE1 -656 TT) had a significantly increased risk of NIHL (adjusted OR 1.91, 95% CI 1.27-2.88).


CONCLUSIONS
Our study identified that the APE1 -656 T>G polymorphism may contribute to the susceptibility of NIHL.
Kunshan Municipal Center for Disease Prevention and Control, Kunshan, China.|Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China.
Huanxi
H
Shen
Yangzhou Center for Disease Prevention and Control, Yangzhou, China.
Jianrui
J
Dou
Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China.|Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, Nanjing, 210009, China.
Lei
L
Han
Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, Nanjing, 210009, China.
Ying
Y
Bai
The First People's Hospital of Kunshan, Kunshan, China.
Qian
Q
Li
Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, Nanjing, 210009, China.
Zhiqiang
Z
Hong
Kunshan Municipal Center for Disease Prevention and Control, Kunshan, China.
Jian
J
Shi
Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, Nanjing, 210009, China.
Hengdong
H
Zhang
Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, Nanjing, 210009, China.
Feng
F
Zhang
Kunshan Municipal Center for Disease Prevention and Control, Kunshan, China.
Cheng
C
Du
Kunshan Municipal Center for Disease Prevention and Control, Kunshan, China.
Zhimin
Z
Tong
Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China. zhubl@jscdc.cn.|Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, Nanjing, 210009, China. zhubl@jscdc.cn.
Baoli
B
Zhu
D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006317:Hearing Loss, Noise-Induced / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009623:Noise, Occupational / Q000009:adverse effects; D009784:Occupational Diseases / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors
C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase
APE1; Noise-induced hearing loss susceptibility; Polymorphisms