The high-affinity receptor for IgG, FcγRI, of humans and non-human primates.
Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characterization of macaque Fc receptors so far has focused on the low-affinity Fc receptors, particularly FcγRIIIa. From these studies, it is clear that there are distinct differences between the human and macaque low-affinity receptors and their interaction with human IgG. Relatively little work has been performed on the high-affinity IgG receptor, FcγRI, especially in NHPs. This review will focus on what is currently known of how FcγRI interacts with IgG, from mutation studies and recent crystallographic studies of human FcγRI, and how amino acid sequence differences in the macaque FcγRI may affect this interaction. Additionally, this review will look at the functional consequences of differences in the amino acid sequences between humans and macaques.
Centre for Biomedicine, Burnet Institute, Melbourne, Vic., Australia.|Department of Immunology, Monash University, Melbourne, Vic., Australia.
Alicia M
AM
Chenoweth
Centre for Biomedicine, Burnet Institute, Melbourne, Vic., Australia.
Halina M
HM
Trist
Centre for Biomedicine, Burnet Institute, Melbourne, Vic., Australia.
Peck-Szee
PS
Tan
Centre for Biomedicine, Burnet Institute, Melbourne, Vic., Australia.|Department of Immunology, Monash University, Melbourne, Vic., Australia.|Department of Pathology, University of Melbourne, Melbourne, Vic., Australia.
Bruce D
BD
Wines
Centre for Biomedicine, Burnet Institute, Melbourne, Vic., Australia.|Department of Immunology, Monash University, Melbourne, Vic., Australia.|Department of Pathology, University of Melbourne, Melbourne, Vic., Australia.
P Mark
PM
Hogarth
D000595:Amino Acid Sequence; D000818:Animals; D000915:Antibody Affinity / Q000276:immunology; D001665:Binding Sites; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism; D051379:Mice; D011323:Primates; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D017452:Receptors, IgG / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
D007074:Immunoglobulin G; D017452:Receptors, IgG
Fc receptor; macaque; non-human primate; receptor recycling; therapeutic monoclonal antibody; vaccine