Germinal center selection and the antibody response to influenza.
In this Minireview, we discuss basic aspects of germinal center biology in the context of immunity to influenza infection and speculate on how the simultaneous evolutionary races of virus and antibody may impact our efforts to design a universal influenza vaccine.
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Electronic address: victora@wi.mit.edu.
Gabriel D
GD
Victora
Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA. Electronic address: wilsonp@uchicago.edu.
Patrick C
PC
Wilson
D000818:Animals; D000917:Antibody Formation; D018858:Germinal Center / Q000276:immunology*; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control
D007252:Influenza Vaccines