In vivo antimalarial evaluation of some 2,3-disubstituted-4(3H)-quinazolinone derivatives.
BACKGROUND
Malaria is a neglected tropical parasitic disease affecting billons of people around the globe. Though the number of cases and deaths associated with malaria are decreasing in recent years, it is the most deadly disease in the world. This study aimed at investigating the in vivo antimalarial activities of some 2,3-disubstituted-4(3H)-quinazolinone derivatives.


RESULTS
The in vivo antimalarial activities of the test compounds (6-9 and 11-13) were investigated using the 4-day suppressive standard test in mice infected with chloroquine-sensitive Plasmodium berghei ANKA strain. The tested compounds showed significant antimalarial activities with mean percentage suppression of 43.71-72.86 % which is significantly higher than the negative control group (p < 0.05). Compounds 12 and 13 displayed better antimalarial activities from the group with mean percentage suppression of 67.60 and 72.86 % respectively.


CONCLUSIONS
The tested compounds showed significant in vivo antimalarial activities in mice infected with P. berghi ANKA strain. Thus, 3-aryl-2-(substitutedstyryl)-4(3H)-quinazolinones represent a possible scaffold for the development of antimalarial agents.
Department of Chemistry, Natural and Computational Sciences College, Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia. yihenews@gmail.com.
Yihenew Simegniew
YS
Birhan
Department of Pharmaceutical Chemistry, Alexandria University, Alexandria, 21215, Egypt. adnbekhit@yahoo.com.
Adnan Ahmed
AA
Bekhit
Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia. hymete@yahoo.com.
Ariaya
A
Hymete
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D052999:Quinazolinones / Q000737:chemistry / Q000494:pharmacology*; D023382:Toxicity Tests, Acute
D000962:Antimalarials; D052999:Quinazolinones; C061339:4-hydroxyquinazoline