Intracranial EEG analysis in tumor-related epilepsy: Evidence of distant epileptic abnormalities.
OBJECTIVE
In patients with tumor-related epilepsy (TRE), surgery traditionally focuses on tumor resection; but identification and removal of associated epileptogenic zone may improve seizure outcome. Here, we study spatial relationship of tumor and seizure onset and early spread zone (SOSz). We also perform quantitative analysis of interictal epileptiform activities in patients with both TRE and non-lesional epilepsy in order to better understand the electrophysiological basis of epileptogenesis.


METHODS
Twenty-five patients (11 with TRE and 14 with non-lesional epilepsy) underwent staged surgery using intracranial electrodes. Tumors were outlined on MRI and images were coregistered with post-implantation CT images. For each electrode, distance to the nearest tumor margin was measured. Electrodes were categorized based on distance from tumor and involvement in seizure. Quantitative EEG analysis studying frequency, amplitude, power, duration and slope of interictal spikes was performed.


RESULTS
At least part of the SOSz was located beyond 1.5 cm from the tumor margin in 10/11 patients. Interictally, spike frequency and power were higher in the SOSz and spikes near tumor were smaller and less sharp. Interestingly, peritumoral electrodes had the highest spike frequencies and sharpest spikes, indicating greatest degree of epileptic synchrony. A complete resection of the SOSz resulted in excellent seizure outcome.


CONCLUSIONS
Seizure onset and early spread often involves brain areas distant from the tumor.


CONCLUSIONS
Utilization of epilepsy surgery approach for TRE may provide better seizure outcome and study of the intracranial EEG may provide insight into pathophysiology of TRE.
Department of Neurosurgery, Wayne State University, Detroit, MI, USA; Department of Oncology, Wayne State University, Detroit, MI, USA; Comprehensive Epilepsy Center, Detroit Medical Center, Wayne State University, Detroit, MI, USA; Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
S
S
Mittal
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA.
D
D
Barkmeier
Department of Computer Science, Wayne State University, Detroit, MI, USA.
J
J
Hua
Department of Computer Science, Wayne State University, Detroit, MI, USA.
D S
DS
Pai
Department of Neurology, Wayne State University, Detroit, MI, USA.
D
D
Fuerst
Comprehensive Epilepsy Center, Detroit Medical Center, Wayne State University, Detroit, MI, USA; Department of Neurology, Wayne State University, Detroit, MI, USA.
M
M
Basha
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA; Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL, USA.
J A
JA
Loeb
Comprehensive Epilepsy Center, Detroit Medical Center, Wayne State University, Detroit, MI, USA; Department of Neurology, Wayne State University, Detroit, MI, USA. Electronic address: ashah@med.wayne.edu.
A K
AK
Shah
D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery; D000069280:Electrocorticography / Q000295:instrumentation / Q000379:methods*; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods*; D055815:Young Adult
Brain tumor; Epileptogenic zone; Interictal spikes; Invasive EEG monitoring; Medically-refractory epilepsy; Quantitative EEG analysis