Early psychosis research at Orygen, The National Centre of Excellence in Youth Mental Health.
BACKGROUND
Specialised early intervention (SEI) programs have offered individuals with psychotic disorders and their families new hope for improving illness trajectories and outcomes. The Early Psychosis Prevention and Intervention Centre (EPPIC) was one of the first SEI programs developed in the world, providing services for young people experiencing their first episode of psychosis.


METHODS
We conducted a narrative synthesis of controlled and uncontrolled studies that have been conducted at EPPIC.


CONCLUSIONS
The history of the EPPIC model is first described. This is followed by a discussion of clinical research emerging from EPPIC, including psychopharmacological, psychotherapeutic trials and outcome studies. Neurobiological studies are also described. Issues pertaining to the conduct of clinical research and future research directions are then described. Finally, the impact of the EPPIC model on the Australian environment is discussed.
S M
SM
Cotton
K M
KM
Filia
A
A
Ratheesh
K
K
Pennell
S
S
Goldstone
P D
PD
McGorry
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001315:Australia; D061345:Early Medical Intervention / Q000379:methods*; D006801:Humans; D017063:Outcome Assessment, Health Care; D011613:Psychotherapy / Q000379:methods*; D011618:Psychotic Disorders / Q000188:drug therapy / Q000628:therapy*; D055815:Young Adult
D014150:Antipsychotic Agents