Idiopathic pulmonary hemosiderosis complicated by Down syndrome.
We report the case of a 9-year-old girl with Down syndrome (DS) diagnosed with idiopathic pulmonary hemosiderosis (IPH). Although acute pneumonia complicated by hemolytic anemia was suspected, IPH was finally diagnosed on bronchoscopy. Treatment with prednisolone achieved good clinical response. An association between IPH and DS was not able to be identified, but immunological issues in DS may contribute to the onset of IPH. Recurrent and intractable respiratory symptoms with marked infiltrative shadows in the bilateral lungs and complicated by severe anemia in patients with DS should suggest IPH.
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Hirofumi
H
Watanabe
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Mamoru
M
Ayusawa
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Masataka
M
Kato
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Ami
A
Chou
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Akiko
A
Komori
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Yuriko
Y
Abe
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Masaharu
M
Matsumura
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Hiroshi
H
Kamiyama
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.|Itabashi Medical Association Hospital, Itabashi, Tokyo, Japan.
Hiroyuki
H
Izumi
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Shori
S
Takahashi
D001706:Biopsy; D001999:Bronchoscopy; D002648:Child; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006486:Hemosiderosis / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008171:Lung Diseases / Q000175:diagnosis* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D000097545:Hemosiderosis, Pulmonary
D005938:Glucocorticoids; D011239:Prednisolone
Down syndrome; hemolytic anemia; hemoptysis; idiopathic pulmonary hemosiderosis; prednisolone