Mass spectrometry-guided isolation of two new benzoquinoline alkaloids from Macleaya cordata.
Two new alkaloids, named 2,3-methylenedioxy-7,10-dimethyl-7,8,9,10-tetrahydro-benzoquinoline (1) and 2,3-methylenedioxy-7,10-dimethyl-8-carboxyl-benzoquinoline (2), were detected primarily from the fruits of Macleaya cordata by their different fragmentation pathways. And then isolation of the two compounds was performed by column chromatography and preparative HPLC under the guiding of mass spectrometry. Finally, their structures were determined by spectroscopic analysis.
a School of Pharmacy , Hunan University of Chinese Medicine , Changsha , China.|c Hunan Engineering Research Center of Botanical Extraction , Changsha , China.
Zhi-Xing
ZX
Qing
a School of Pharmacy , Hunan University of Chinese Medicine , Changsha , China.
Yu-Qin
YQ
Xu
a School of Pharmacy , Hunan University of Chinese Medicine , Changsha , China.|c Hunan Engineering Research Center of Botanical Extraction , Changsha , China.
Peng
P
Yang
a School of Pharmacy , Hunan University of Chinese Medicine , Changsha , China.|c Hunan Engineering Research Center of Botanical Extraction , Changsha , China.
Kun
K
Yu
b Hunan Co-Innovation Center for Utilization of Botanicals Functional Ingredients (Hunan) , Hunan Agricultural University , Changsha , China.|c Hunan Engineering Research Center of Botanical Extraction , Changsha , China.
Pi
P
Cheng
a School of Pharmacy , Hunan University of Chinese Medicine , Changsha , China.|b Hunan Co-Innovation Center for Utilization of Botanicals Functional Ingredients (Hunan) , Hunan Agricultural University , Changsha , China.|c Hunan Engineering Research Center of Botanical Extraction , Changsha , China.
Jian-Guo
JG
Zeng
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005638:Fruit / Q000737:chemistry; D013058:Mass Spectrometry; D008516:Medicine, Chinese Traditional; D028101:Papaveraceae / Q000737:chemistry*; D011804:Quinolines; D013056:Spectrophotometry, Ultraviolet
C000611784:2,3-methylenedioxy-7,10-dimethyl-7,8,9,10-tetrahydro-benzoquinoline; D000470:Alkaloids; D011804:Quinolines
2,3-methylenedioxy-7,10- dimethyl-7,8,9,10-tetrahydrobenzoquinoline; 2,3-methylenedioxy-7,10-dimethyl-8-carboxyl-benzoquinoline; Macleaya cordata; benzoquinoline alkaloids; mass spectrometry-guided isolation