PEGylated Cu3BiS3 hollow nanospheres as a new photothermal agent for 980 nm-laser-driven photothermochemotherapy and a contrast agent for X-ray computed tomography imaging.
Developing multifunctional near-infrared (NIR) light-driven photothermal agents is in high demand for efficient cancer therapy. Herein, PEGylated Cu3BiS3 hollow nanospheres (HNSs) with an average diameter of 80 nm were synthesized through a facile ethylene glycol-mediated solvothermal route. The obtained PEGylated Cu3BiS3 HNSs exhibited strong NIR optical absorption with a large molar extinction coefficient of 4.1 × 10(9) cm(-1) M(-1) at 980 nm. Under the irradiation of a 980 nm laser with a safe power density of 0.72 W cm(-2), Cu3BiS3 HNSs produced significant photothermal heating with a photothermal transduction efficiency of 27.5%. The Cu3BiS3 HNSs also showed a good antitumoral drug doxorubicin (DOX) loading capacity and pH- and NIR-responsive DOX release behaviors. At a low dosage of 10 μg mL(-1), HeLa cells could be efficiently killed through a synergistic effect of chemo- and photothermo-therapy respectively based on the DOX release and the photothermal effect of Cu3BiS3 HNSs. In addition, Cu3BiS3 HNSs displayed a good X-ray computed tomography (CT) imaging capability. Furthermore, Cu3BiS3 HNSs could be used for efficient in vivo photothermochemotherapy and X-ray CT imaging of mice bearing melanoma skin cancer. This multifunctional theranostic nanomaterial shows potential promise for cancer therapy.
Nanomaterials and Chemistry Key Laboratory, Wenzhou University, Wenzhou, Zhejiang 325027, P. R. China. dkma@wzu.edu.cn yukang62@126.com smhuang@wzu.edu.cn.
Shu-Mei
SM
Zhou
Nanomaterials and Chemistry Key Laboratory, Wenzhou University, Wenzhou, Zhejiang 325027, P. R. China. dkma@wzu.edu.cn yukang62@126.com smhuang@wzu.edu.cn.
De-Kun
DK
Ma
Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P. R. China.
Sheng-Hui
SH
Zhang
Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P. R. China.
Wei
W
Wang
Nanomaterials and Chemistry Key Laboratory, Wenzhou University, Wenzhou, Zhejiang 325027, P. R. China. dkma@wzu.edu.cn yukang62@126.com smhuang@wzu.edu.cn.
Wei
W
Chen
Nanomaterials and Chemistry Key Laboratory, Wenzhou University, Wenzhou, Zhejiang 325027, P. R. China. dkma@wzu.edu.cn yukang62@126.com smhuang@wzu.edu.cn.
Shao-Ming
SM
Huang
Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P. R. China.
Kang
K
Yu
D000818:Animals; D001729:Bismuth / Q000737:chemistry / Q000494:pharmacology; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D006979:Hyperthermia, Induced; D028022:Low-Level Light Therapy; D008545:Melanoma / Q000000981:diagnostic imaging / Q000628:therapy; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry / Q000494:pharmacology; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D004337:Drug Carriers; D013440:Sulfides; D003300:Copper; D004317:Doxorubicin; D001729:Bismuth