"Graft to" Synthesis and Ibuprofen-Loading Performance of pH-Sensitive PMAA-Silica Hybrid Nanoparticles with Controlled Bimodal Mesopores.
Bimodal mesoporous silicas (BMMs) have been proved to be a good drug-loaded carrier. However, it did not provide stimuli sensitivity or controlled release performance yet. In the present work, a "smart" mesoporous silica-based pH-dependent [poly(methacrylic acid)]-silica hybrid nanoparticles (P/NN-BMMs) drug delivery system was developed and evaluated with ibuprofen (IBU) as a model drug. P/NN-BMMs were prepared by coating poly(methacrylic acid) (PMAA) onto amino-modified surface of BMMs via the "graft to" strategy. The structure and texture of resultant hybrid nanoparticles were determined with X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared, thermogravimetric analysis, N2 sorption isotherms, and elemental analysis. The PMAA acts as a molecular switch to achieve controlled drug release and the amount of grafted-PMAA can remarkably affect its performance. The drug-loading rate is decreased markedly with the increasing of the amount of grafted-PMAA, meanwhile, the drug-loading kinetics on P/NN-BMMs fits Korsmeyer-Peppas model. In addition, the drug-release amount from drug-loaded P/NN-BMMs is pH dependent, showing an increasing tendency with the increase of pH value.
Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, People's Republic of China.
Jing
J
Han
Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, People's Republic of China. Electronic address: jhsun@bjut.edu.cn.
Jihong
J
Sun
Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, People's Republic of China.
Shiyang
S
Bai
Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, People's Republic of China.
Hamida
H
Panezai
Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, People's Republic of China.
Xiaoqi
X
Jin
Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, People's Republic of China.
Xia
X
Wu
D000327:Adsorption; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D046529:Microscopy, Electron, Transmission / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D014961:X-Ray Diffraction / Q000379:methods
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D012822:Silicon Dioxide; D007052:Ibuprofen
controlled release; inclusion compounds; kinetics; mesoporous silica; nanoparticles; pH sensitive carriers; poly(methacrylic acid); polymer