Cognitive screening in Parkinson's disease: Comparison of the Parkinson Neuropsychometric Dementia Assessment (PANDA) with 3 other short scales.
BACKGROUND
Cognitive screening is crucial in Parkinson's disease (PD). However, there is still a lack of short tools in French. In this study, we aimed to compare the Parkinson Neuropsychometric Dementia Assessment (PANDA) with the Mini Mental Parkinson (MMP), the Mini Mental State Examination (MMSE) and the Clock Test in French-speaking patients. We also aimed to propose cut-off scores for cognitive impairment and dementia for the French language version of the PANDA.


METHODS
Fifty-one patients with PD took the PANDA, the MMSE, the MMP, and the Clock Test. They also underwent extensive neuropsychological testing by a neuropsychologist who was blinded to the above-mentioned screening test results. Patients were classified as either having normal cognition (n=15), mild cognitive impairment (n=20) or dementia (n=16).


RESULTS
When compared with the three other screening tools, the PANDA exhibited the highest area under the curve (AUC) for both cognitive disorders and dementia. Using the cut-off scores proposed for the German version, the PANDA had 94% specificity and 100% sensitivity for dementia and 100% and 72%, respectively for cognitive disorders.


CONCLUSIONS
In our study, the PANDA exhibited a higher discriminative power than the three other tests in detecting cognitive disorders and dementia. In PD patients, the PANDA should thus be considered for the detection of cognitive impairment in routine clinical practice.
Rehabilitation unit, hôpital fribourgeois Billens, 1, rue de l'Hôpital, 1681 Billens, Switzerland. Electronic address: anne-isabelle.gasser@h-fr.ch.
A-I
AI
Gasser
University of Basel, Basel, Switzerland.
P
P
Calabrese
Institute of Gerontology & Center for Neuropsychological Diagnostics and Intervention (CeNDI), University of Vechta, Vechta, Germany; Department of Neurology, University Clinic Cologne, Cologne, Germany.
E
E
Kalbe
Department of Neurology, University Clinic Cologne, Cologne, Germany.
J
J
Kessler
Rehabilitation unit, hôpital fribourgeois Billens, 1, rue de l'Hôpital, 1681 Billens, Switzerland.
P
P
Rossier
D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000209:etiology; D003704:Dementia / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000379:methods; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics / Q000379:methods
Cognition; Cognitive impairment; Dementia; Démence; Dépistage; Maladie de Parkinson; Neuropsychological assessment; Parkinson's disease; Screening test; Troubles cognitifs