Correlation of Single Nucleotide Polymorphism 35-Kb Upstream of HLA-C and Clinical Profile of Multidrug-Resistant Tuberculosis.
BACKGROUND
The SNP HLA-C-35 kb (rs9264942) may contribute to the host immune defense mechanism by affecting the cell surface expression pattern of HLA-C and antigen presentation to CD8+ cytotoxic cells. Thus, this SNP may contribute to intracellular multidrug-resistant (MDR)-tuberculosis (TB) infection.


OBJECTIVE
To examine the association between the SNP HLA-C-35 kb (rs9264942) and the clinical profile of MDR-TB infection.


METHODS
MDR-TB-positive patients were followed from May 2012 to December 2013 to observe the progression of MDR-TB infection. Non-TB individuals and non-MDR-TB individuals were also recruited as controls.


METHODS
The patients' HLA-C-35 kb (rs9264942) status was determined by PCR.


RESULTS
The C allele was slightly more frequent in the MDR-TB patients than in the non-MDR TB patients (OR= 1.28; 95% CI: 0.701 - 2.328). The C allele was found to be more frequent in the MDR-TB patients exhibiting pulmonary fibrosis (OR= 2.13; 95% CI: 0.606 - 7.480) or pulmonary infiltrates (OR= 3.17; 95% CI: 0.690 - 14.598) and among the MDR-TB patients who were classified as underweight (OR= 8.00; 95% CI: 1.261 - 50.770). The CC genotype was associated with the treatment after failure of category II group (OR= 4.17; 95% CI: 1.301 - 13.346).


CONCLUSIONS
The C allele SNP HLA-C-35 kb (rs9264942) may contribute to the clinical profile in MDR-TB infection.
A-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia; Department of Microbiology Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia .
Marwoto
A-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia .
Umi Hani' Vismayanti
UH
Lismana
A-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia; Department of Microbiology Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia; Center of Biotechnology and Biodiversity Research and Development, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia .
Afiono Agung
AA
Prasetyo
Department of Pulmonology Faculty of Medicine, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia .
Suradi
A-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia; Department of Pulmonology Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia .
Reviono
A-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia; Department of Pulmonology, Dr. Moewardi General Hospital, Jl. Kolonel Sutarto 132, Surakarta, Indonesia; Doctoral Program of Medical Sciences Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia .
Harsini
Human leukocyte antigen C; Major histocompatibility complex class I; Rs9264942