The paradox of the serrated sickle erythrocyte: The importance of the red blood cell membrane topography.
Red blood cell rheology and adhesiveness play a key role in the occurrence of vaso-occlusive like events in sickle cell anemia. The present paper reviews counter-intuitive findings supporting that rigid and serrated sickle red blood cells do not initiate vaso-occlusion. Instead, the less rigid red blood cells could initiate vaso-occlusion because of their increased adhesiveness to the vascular wall. We suspect that stiffness of sickle erythrocytes and the topography of RBC membrane are factors affecting adhesion to the endothelium.
Cardeza Foundation for hematologic Research, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Samir K
SK
Ballas
Laboratory CRIS-EA 647 -Section "Vascular Biology and Red Blood Cell", University Claude Bernard Lyon 1, Villeurbanne, France.
Philippe
P
Connes
D000755:Anemia, Sickle Cell / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D004913:Erythrocytes, Abnormal / Q000378:metabolism*; D006801:Humans; D012212:Rheology
Sickle; serrated sickle; topography