Nanoparticle based insulin delivery system: the next generation efficient therapy for Type 1 diabetes.
Diabetic cases have increased rapidly in recent years throughout the world. Currently, for type-1 diabetes mellitus (T1DM), multiple daily insulin (MDI) injections is the most popular treatment throughout the world. At this juncture, researchers are trying to develop different insulin delivery systems, especially through oral and pulmonary route using nanocarrier based delivery system. This next generation efficient therapy for T1DM may help to improve the quality of life of diabetic patients who routinely employ insulin by the subcutaneous route. In this paper, we have depicted various next generation nanocarrier based insulin delivery systems such as chitosan-insulin nanoparticles, PLGA-insulin nanoparticles, dextran-insulin nanoparticles, polyalkylcyanoacrylated-insulin nanoparticles and solid lipid-insulin nanoparticles. Modulation of these insulin nanocarriers may lead to successful oral or pulmonary insulin nanoformulations in future clinical settings. Therefore, applications and limitations of these nanoparticles in delivering insulin to the targeted site have been thoroughly discussed.
Institute For Skeletal Aging, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea. microbio.garima@gmail.com.|Amity Institute of Nanotechnology, Amity University, Noida, Uttar Pradesh, India. microbio.garima@gmail.com.
Garima
G
Sharma
Institute For Skeletal Aging, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea. boneresearch@hallym.ac.kr.
Ashish Ranjan
AR
Sharma
Institute For Skeletal Aging, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea. jsnam88@hallym.ac.kr.
Ju-Suk
JS
Nam
Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India. georgecp77@yahoo.co.in.
George Priya C
GP
Doss
Institute For Skeletal Aging, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea. totalhip@hallym.ac.kr.
Sang-Soo
SS
Lee
Institute For Skeletal Aging, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea. drchiranjib@yahoo.com.|Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida, India. drchiranjib@yahoo.com.
Chiranjib
C
Chakraborty
D000284:Administration, Oral; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D053758:Nanoparticles / Q000737:chemistry*
D004337:Drug Carriers; D007328:Insulin