Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis.
Sepsis is a devastating disease that can affect humans at any time between neonates and the elderly and is associated with mortality rates that range from 30 to 80%. Despite intensive efforts, its treatment has remained the same over the last few decades. Fc receptors regulate multiple immune responses and have been investigated in diverse complex diseases. FcγRIIA (CD32A) is an immunoreceptor, tyrosine-based activation motif-bearing receptor that binds immunoglobulin G and C-reactive protein, important opsonins in host defense. We conducted a study of 702 patients (184 healthy individuals, 171 non-infected critically ill patients, and 347 sepsis patients) to investigate if genetic polymorphisms in the CD32A coding region affect the risk of septic shock. All individuals were genotyped for a variant at position 131 of the FcγRIIA gene. We found that allele G, associated with the R131 genotype, was significantly more frequent in septic patients than in the other groups (p = 0.05). Our data indicate that FcγRIIA genotyping can be used as a marker of genetic susceptibility to sepsis.
Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil.
Jaqueline
J
Beppler
Proteins and Molecular Analysis Unit, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Patrícia
P
Koehler-Santos
Gene Therapy Unit, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.|Postgraduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Gabriela
G
Pasqualim
Gene Therapy Unit, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Ursula
U
Matte
School of Biosciences and Hospital São Lucas, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Clarice Sampaio
CS
Alho
School of Biosciences and Hospital São Lucas, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Fernando Suparregui
FS
Dias
Postgraduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Thayne Woycinck
TW
Kowalski
Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil.
Irineu Tadeu
IT
Velasco
Inserm Unit 1149 and ERL Cnrs 8252, Center for Research on Inflammation, University Paris Diderot, Paris, France.
Renato C
RC
Monteiro
Emergency Medicine Department, University of Sao Paulo, Sao Paulo, Brazil. pinheirofabiano@hotmail.com.|Laboratório de Emergências Clínicas (LIM-51), Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455 sala 3189, CEP 01246-000, São Paulo, SP, Brazil. pinheirofabiano@hotmail.com.
Fabiano
F
Pinheiro da Silva
D016638:Critical Illness; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017452:Receptors, IgG / Q000235:genetics*; D018805:Sepsis / Q000235:genetics* / Q000382:microbiology
C445323:FCGR2A protein, human; C080568:Fc gamma receptor IIA; D005819:Genetic Markers; D017452:Receptors, IgG
biomarkers; critical care; genetic susceptibility; infection; inflammation