Quantitative profiling of tissue drug distribution by MS imaging.
This article highlights recent advancements in the quantitative measurement of drug distribution by MS imaging (MSI). Quantitation by MSI was recently considering the primary disadvantage of MSI approaches particularly when compared with widely used autoradiography techniques. These approaches show significant progress in the area of quantitative MSI and have been used in numerous drug and metabolite distribution measurements. As quantitative limitations are overcome, the use of MSI in drug development should increase significantly providing key insights into both tissue-target validation as well as identifying off tissue-target issues with drug delivery.
Agios Pharmaceuticals, Cell Metabolism, 88 Sidney Street, Cambridge, MA 02139-4169, USA.
David
D
Pirman
D000818:Animals; D001345:Autoradiography; D001569:Benzodiazepines / Q000032:analysis / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D000077152:Olanzapine; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014018:Tissue Distribution; D051598:Whole Body Imaging
D004364:Pharmaceutical Preparations; D001569:Benzodiazepines; D000077152:Olanzapine