Amino Catalytic Oxidative Thioesterification Approach to α-Ketothioesters.
An efficient metal-free method for the synthesis of α-ketothioesters is described for the first time. This reaction features the ability of pyrrolidine to fine-tune the reaction between 2-oxoaldehyde and thiols through iminium to the desired product in moderate to good yields. As an advantage, no external oxidants or metal catalysts are required in our method. Reactions performed under modified conditions lead to an apparent balance in reactivity of secondary amine and thiols toward 2-oxoaldehydes.
Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-18001, India.|Academy of Scientific and Innovative Research , Canal Road, Jammu-18001, India.
Nagaraju
N
Mupparapu
Quality Control and Quality Assurance, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-18001, India.
Manoj
M
Khushwaha
Quality Control and Quality Assurance, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-18001, India.
Ajai Prakash
AP
Gupta
Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-18001, India.
Parvinder Pal
PP
Singh
Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-18001, India.|Academy of Scientific and Innovative Research , Canal Road, Jammu-18001, India.
Qazi Naveed
QN
Ahmed