Exploring miRNA based approaches in cancer diagnostics and therapeutics.
MicroRNAs (miRNAs), a highly conserved class of tissue specific, small non-protein coding RNAs maintain cell homeostasis by negative gene regulation. Proper controlling of miRNA expression is required for a balanced physiological environment, as these small molecules influence almost every genetic pathway from cell cycle checkpoint, cell proliferation to apoptosis, with a wide range of target genes. Deregulation in miRNAs expression correlates with various cancers by acting as tumor suppressors and oncogenes. Although promising therapies exist to control tumor development and progression, there is a lack of efficient diagnostic and therapeutic approaches for delineating various types of cancer. The molecularly different tumors can be differentiated by specific miRNA profiling as their phenotypic signatures, which can hence be exploited to surmount the diagnostic and therapeutic challenges. Present review discusses the involvement of miRNAs in oncogenesis with the analysis of patented research available on miRNAs.
Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida 201307, Uttar Pradesh, India.
Shivangi
S
Mishra
Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida 201307, Uttar Pradesh, India.
Tanuja
T
Yadav
Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida 201307, Uttar Pradesh, India. Electronic address: vibha.rani@jiit.ac.in.
Vibha
V
Rani
D063646:Carcinogenesis; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology*; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D009857:Oncogenes
D035683:MicroRNAs
Cancer; MicroRNAs; Oncogenes; Patents; Therapeutics; Tumor suppressors