The impact of an experimentally induced increase in arterial blood pressure on left ventricular twist mechanics.
The effects of isometric hand-grip exercise (IHG) coupled with a period of postexercise circulatory occlusion (OCC; known to sustain exercise-induced increases in blood pressure while facilitating a decrease in heart rate) on left ventricular (LV) twist mechanics was examined. Two-dimensional speckle-tracking echocardiography was used to assess LV apical and basal rotation and LV twist in 19 healthy participants (23 ± 2 years old) at rest, during 3 min of IHG (performed at 40% maximal voluntary contraction) and 3 min of OCC immediately following IHG. The IHG elicited significant (P < 0.001) increases in mean arterial pressure (rest, 91 ± 1 mmHg; IHG, 122 ± 2 mmHg) and heart rate (rest, 65 ± 2 beats min(-1); IHG, 91 ± 4 beats min(-1)). Mean arterial pressure remained elevated during OCC (116 ± 2 mmHg; P < 0.001 versus rest), whereas heart rate returned to resting levels (68 ± 3 beats min(-1); P = 0.159 versus rest). Apical rotation decreased significantly (P < 0.01) by 10 ± 5% during IHG and 21 ± 4% during OCC, whereas basal rotation remained unchanged from rest. Left ventricular twist decreased from rest to IHG (12 ± 5%; P = 0.015) and OCC (21 ± 4%; P = 0.001), whereas a decrease in LV untwist rate was observed only during OCC. An increase in blood pressure generated by IHG, and maintained by a period of OCC, impairs aspects of LV twist mechanics. Postexercise circulatory occlusion isolated the effect of the arterial blood pressure rise (from heart rate), magnifying the impairment of LV twist mechanics when compared with IHG, whilst also negatively impacting LV relaxation. We propose that a protocol using isometric exercise followed by circulatory occlusion provides a method for studying the effects of blood pressure changes on LV twist mechanics.
Menzies Health Institute Queensland, Gold Coast Campus, Griffith University, Queensland, Australia.
B
B
Balmain
Menzies Health Institute Queensland, Gold Coast Campus, Griffith University, Queensland, Australia.
G M
GM
Stewart
Menzies Health Institute Queensland, Gold Coast Campus, Griffith University, Queensland, Australia.
A
A
Yamada
Menzies Health Institute Queensland, Gold Coast Campus, Griffith University, Queensland, Australia.|Cardiology Division, The Prince Charles Hospital, Brisbane, Queensland, Australia.
J
J
Chan
Menzies Health Institute Queensland, Gold Coast Campus, Griffith University, Queensland, Australia.
L J
LJ
Haseler
Menzies Health Institute Queensland, Gold Coast Campus, Griffith University, Queensland, Australia.
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S
Sabapathy
D000293:Adolescent; D000328:Adult; D062186:Arterial Pressure; D003331:Coronary Vessels / Q000502:physiology; D005542:Forearm / Q000098:blood supply; D018737:Hand Strength; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007537:Isometric Contraction; D008297:Male; D012039:Regional Blood Flow; D012399:Rotation; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology; D055815:Young Adult