Four Synchronous Primary Malignancies of the Breast, Lung, Colon and Esophagus.
The literature contains few reports of patients with four more or more synchronous primary malignancies. We report the case of a 74-year-old woman who presented with synchronous primary malignant neoplasms of the breast (metaplastic carcinoma), lung (squamous cell carcinoma), esophagus (adenocarcinoma), and colon (adenocarcinoma). She was treated with multimodality therapy and demonstrated a favorable response at early follow-up. To our knowledge, this combination of synchronous primary malignancies has not been previously reported. The management of patients with multiple synchronous primary malignancies introduces a number of unique challenges which necessitate highly individualized treatment plans that may not strictly adhere to standard practices in the setting of a single malignancy.
Department of General Surgery; Rush University Medical Center, Chicago, IL, U.S.A.
Matthew
M
Klairmont
Department of General Surgery; Rush University Medical Center, Chicago, IL, U.S.A.
Katherine
K
Kopkash
Department of General Surgery; Rush University Medical Center, Chicago, IL, U.S.A.
Joanne
J
Favuzza
Department of Medicine; Rush University Medical Center, Chicago, IL, U.S.A.
Marisa
M
Hill
Department of Medicine; Rush University Medical Center, Chicago, IL, U.S.A.
Ruta
R
Rao
Department of Pathology; Rush University Medical Center, Chicago, IL, U.S.A.
Brett
B
Mahon
Department of Cardiovascular and Thoracic Surgery; Rush University Medical Center, Chicago, IL, U.S.A.
Christopher W
CW
Seder
D000230:Adenocarcinoma / Q000556:secondary* / Q000628:therapy; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000628:therapy; D003110:Colonic Neoplasms / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D011379:Prognosis
Synchronous primary malignant neoplasms; individualized treatment; multiple primary malignant neoplasms