Past, Present, and Future of Nerve Conduits in the Treatment of Peripheral Nerve Injury.
With significant advances in the research and application of nerve conduits, they have been used to repair peripheral nerve injury for several decades. Nerve conduits range from biological tubes to synthetic tubes, and from nondegradable tubes to biodegradable tubes. Researchers have explored hollow tubes, tubes filled with scaffolds containing neurotrophic factors, and those seeded with Schwann cells or stem cells. The therapeutic effect of nerve conduits is improving with increasing choice of conduit material, new construction of conduits, and the inclusion of neurotrophic factors and support cells in the conduits. Improvements in functional outcomes are expected when these are optimized for use in clinical practice.
Medical Center, Tsinghua University, Beijing 8610084, China ; Department of Orthopedics, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 86838010, China ; Institute of Tissue Engineering, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 86110122, China.
Aikeremujiang
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Muheremu
Institute of Tissue Engineering, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 86110122, China.
Qiang
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Ao
D000818:Animals; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D059348:Peripheral Nerve Injuries / Q000473:pathology / Q000628:therapy*; D019736:Prostheses and Implants