Patterns of Performance on the Modified Cued Recall Test in Spanish Adults With Down Syndrome With and Without Dementia.
The assessment of memory decline in people with intellectual disability (ID) is more difficult than in the general population, due to a lack of appropriate instruments and to preexisting cognitive impairment. The aim of this study was to describe performance of healthy adults with Down syndrome (healthy-DS; prospectively cohort) on a Spanish version of the modified Cued Recall Test (mCRT). We also recruited retrospectively a cohort of DS subjects with Dementia of the Alzheimer's Type (DS-DAT). Healthy-DS obtained higher scores on free recall and total score than DS-DAT. Age was the main factor associated with decreasing mCRT scores. The mCRT was useful in DS subjects with ID at the upper end of the spectrum or ID in the middle range of the spectrum, and discriminated well between DS subjects with and without DAT.
Bessy Benejam, Down Medical Centre (CMD), Catalan Down Syndrome Foundation (FCSD), Barcelona, Spain;
Bessy
B
Benejam
Juan Fortea, Down Medical Centre (CMD), Catalan Down Syndrome Foundation (FCSD), Barcelona, Spain; Memory Unit, Neurology Department, Hospital de la Santa Creu I Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona;
Juan
J
Fortea
Rafael Molina-López, Clinical Research, Catalan Down Syndrome Foundation, Barcelona, Spain; and.
Rafael
R
Molina-López
Sebastià Videla, Clinical Research, Catalan Down Syndrome Foundation (FCSD), Barcelona, Spain; Department of Experimental and Health Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra.
Sebastià
S
Videla
D000328:Adult; D000367:Age Factors; D000544:Alzheimer Disease / Q000453:epidemiology / Q000503:physiopathology*; D015897:Comorbidity; D004314:Down Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D013030:Spain
Cued Recall Test; Down syndrome; dementia; intellectual disability; memory; neuropsychological assessment