Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd.
Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1), a new sesquiterpene: 4,9(α)-dihydroxy-nardosin-6-en (2) and an already known labdane-type diterpene: 15-hydroxy-8(17),13(E)-labdadiene-19-carboxilic acid (3). Compounds 1-3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines.
a Department of Pharmacology , Shahrekord University of Medical Sciences , Shahrekord , Iran.
Mahmood
M
Rafieian-Kopaei
b Chemistry Department , Yasouj University , Yasouj , Iran.
Ibrahim
I
Suleimani Dehkordi
c Isfahan Pharmaceutical Sciences Research Center , Isfahan University of Medical Sciences , Isfahan , Iran.|d Isfahan Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmacognosy , Isfahan University of Medical Sciences , Isfahan , Iran.
Mustafa
M
Ghanadian
b Chemistry Department , Yasouj University , Yasouj , Iran.
Ardeshir
A
Shokrollahi
c Isfahan Pharmaceutical Sciences Research Center , Isfahan University of Medical Sciences , Isfahan , Iran.
Mahmoud
M
Aghaei
e Phytochemistry Research Center and School of Pharmacy , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Ayatollahi
A
Syed Majid
f Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.|g Faculty of Science, Department of Biochemistry , King Abdulaziz University , Jeddah , Saudi Arabia, Isfahan.
M Iqbal
MI
Choudhary
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D018653:Juniperus / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis; D018515:Plant Leaves / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
Cupressaceae; Juniperus foetidissima; bladder cancer cell; cytotoxicity; ovary cancer cell