First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States.
Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous azole exposure have been reported in Europe, Asia, the Middle East, Africa, and Australia. Here, we report the detection of both the TR34 L98H and TR46 Y121F T289A mutations in confirmed A. fumigatus isolates collected in institutions in the United States. These mutations, other mutations known to cause azole resistance, and azole MICs are reported here.
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA wiederholdn@uthscsa.edu.
Nathan P
NP
Wiederhold
Hospital Universitario La Paz, Madrid, Spain.
Veronica Garcia
VG
Gil
Phoenix VA Healthcare, Phoenix, Arizona, USA University of Arizona College of Medicine, Phoenix, Arizona, USA.
Felipe
F
Gutierrez
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Jonathan R
JR
Lindner
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Mohammad T
MT
Albataineh
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Dora I
DI
McCarthy
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Carmita
C
Sanders
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Hongxin
H
Fan
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Annette W
AW
Fothergill
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Deanna A
DA
Sutton
D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D001393:Azoles / Q000494:pharmacology*; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D020125:Mutation, Missense; D058886:Sterol 14-Demethylase / Q000235:genetics*; D014481:United States
D000935:Antifungal Agents; D001393:Azoles; D058886:Sterol 14-Demethylase