Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review.
Nowadays, S53P4 bioactive glass is indicated as a bone graft substitute in various clinical applications. This review provides an overview of the current published clinical results on indications such as craniofacial procedures, grafting of benign bone tumour defects, instrumental spondylodesis, and the treatment of osteomyelitis. Given the reported results that are based on examinations, such as clinical examinations by the surgeons, radiographs, CT, and MRI images, S53P4 bioactive glass may be beneficial in the various reported applications. Especially in craniofacial reconstructions like mastoid obliteration and orbital floor reconstructions, in grafting bone tumour defects, and in the treatment of osteomyelitis very promising results are obtained. Randomized clinical trials need to be performed in order to determine whether bioactive glass would be able to replace the current golden standard of autologous bone usage or with the use of antibiotic containing PMMA beads (in the case of osteomyelitis).
Orthopaedic Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.
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van Gestel
Department of Orthopaedic Surgery, CAPHRI Research School, Maastricht University Medical Centre, P.O. Box 5800, 6229 HX Maastricht, Netherlands.
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Geurts
Department of Orthopaedic Surgery, CAPHRI Research School, Maastricht University Medical Centre, P.O. Box 5800, 6229 HX Maastricht, Netherlands.
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Hulsen
Orthopaedic Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.
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van Rietbergen
Orthopaedic Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands ; Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands ; Institute for Biomechanics, Swiss Federal Institute of Technology Zürich (ETHZ), Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland.
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Hofmann
Orthopaedic Biomechanics Group, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands ; Department of Orthopaedic Surgery, CAPHRI Research School, Maastricht University Medical Centre, P.O. Box 5800, 6229 HX Maastricht, Netherlands.
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Arts
D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D017102:Fracture Healing / Q000187:drug effects*; D005898:Glass; D006801:Humans; D010019:Osteomyelitis / Q000188:drug therapy*
D018786:Bone Substitutes; C403922:bioactive glass S53P4