Expression of cholecystokinin receptors in colon cancer and the clinical correlation in Taiwan.
Cholecystokinin and gastrin receptors are upregulated in many human digestive malignancies; however, the correlation of their expressions with severity of colon carcinoma remains sketchy. Here, we determined the expression of cholecystokinin-1 and cholecystokinin-2 receptor, CCK1R and CCK2R, in colon carcinomas and investigated their correlations with clinicopathological characteristics and 1-year survival rate. Expression of CCK1R and CCK2R was determined by immunohistochemical assay in tissue samples obtained from 97 surgical specimens. Clinicopathological character analysis revealed that higher expression of cytoplasmic CCK1R and CCK2R was significantly associated with several variables including the depth of tumor invasion (P = 0.001), venous invasion (P = 0.023), and progression stage (P = 0.013). In addition, immunohistochemical staining revealed statistically significant associations of nuclear CCK1R expression with higher lymphatic invasion (P = 0.042), progression stage (P = 0.025), and unfavorable survival (P = 0.025). Interestingly, we found no link between nuclear CCK2R expression and all the clinicopathological characteristics examined. Taken these, our findings indicate that nuclear CCK1R represents a potential biomarker for poor prognosis, and CCK1R may play a role differing from CCK2R in colon carcinogenesis.
Department of Pathology, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.
Bee-Piao
BP
Huang
Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Road, Taichung, 402, Taiwan.
Chun-Hsiang
CH
Lin
Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Road, Taichung, 402, Taiwan.
Yi-Ching
YC
Chen
Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Road, Taichung, 402, Taiwan. kaosh@csmu.edu.tw.|Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan. kaosh@csmu.edu.tw.
Shao-Hsuan
SH
Kao
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D043886:Receptor, Cholecystokinin A / Q000378:metabolism*; D043887:Receptor, Cholecystokinin B / Q000378:metabolism*; D016019:Survival Analysis; D013624:Taiwan
D014408:Biomarkers, Tumor; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B
Cholecystokinin; Cholecystokinin-1 receptor; Cholecystokinin-2 receptor; Colon cancer; One-year survival