Radiotherapy in Gorlin Syndrome: Can It Be Safe and Effective in Adult Patients?
Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant disorder with multiple manifestations including early onset of cutaneous basal cell carcinomas (BCCs). Radiotherapy has traditionally been contraindicated due to reports of BCC induction. We describe here a patient treated successfully with radiotherapy with no tumour induction at 57 months of follow-up. A comprehensive literature review of radiotherapy outcomes in patients with Gorlin syndrome suggests radiotherapy may be a feasible treatment option for adult patients with treatment refractory lesions or surgical contraindication.
Division of Radiation Oncology, Department of Oncology, University of Alberta & Cross Cancer Institute, Edmonton, Canada baker2@ualberta.ca.
Sarah
S
Baker
Division of Radiation Oncology, Department of Oncology, University of Alberta & Cross Cancer Institute, Edmonton, Canada.
Kurian
K
Joseph
Department of Radiation Oncology, University of Saskatchewan & Allan Blair Cancer Center, Regina, Canada.
Patricia
P
Tai
D000368:Aged; D001478:Basal Cell Nevus Syndrome / Q000473:pathology / Q000532:radiotherapy*; D005153:Facial Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy*
Gorlin syndrome; basal cell carcinoma; nevoid basal cell carcinoma syndrome; radiotherapy; secondary malignancy