The use of alvimopan for postoperative ileus in small and large bowel resections.
Transient ileus is a normal physiologic process after surgery. When prolonged, it is an important contributor to postoperative complications, increased length of stay and increased healthcare costs. Efforts have been made to prevent and manage postoperative ileus; alvimopan is an oral, peripheral μ-opioid receptor antagonist, and the only currently US FDA-approved medication to accelerate the return of gastrointestinal function postoperatively.
a University Hospitals Case Medical Center, Division of Colorectal Surgery, Cleveland, Ohio, USA.
Justin T
JT
Brady
a University Hospitals Case Medical Center, Division of Colorectal Surgery, Cleveland, Ohio, USA.
Eslam M G
EM
Dosokey
a University Hospitals Case Medical Center, Division of Colorectal Surgery, Cleveland, Ohio, USA.
Benjamin P
BP
Crawshaw
a University Hospitals Case Medical Center, Division of Colorectal Surgery, Cleveland, Ohio, USA.
Scott R
SR
Steele
a University Hospitals Case Medical Center, Division of Colorectal Surgery, Cleveland, Ohio, USA.
Conor P
CP
Delaney
D000284:Administration, Oral; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D045823:Ileus / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D007420:Intestine, Large / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism; D020127:Recovery of Function; D012307:Risk Factors; D016896:Treatment Outcome
D005765:Gastrointestinal Agents; D009292:Narcotic Antagonists; D010880:Piperidines; D017450:Receptors, Opioid, mu; C419502:alvimopan
alvimopan; bowel resection; laparoscopy; postoperative ileus; μ-opioid antagonist