Cross-validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease.
The frequency of executive disorders in mild-to-moderate Alzheimer disease (AD) has been demonstrated by the application of a comprehensive battery. The present study analyzed data from 2 recent multicenter studies based on the same executive battery. The objective was to derive a shortened battery by using the GREFEX population as a training dataset and by cross-validating the results in the REFLEX population. A total of 102 AD patients of the GREFEX study (MMSE=23.2±2.9) and 72 patients of the REFLEX study (MMSE=20.8±3.5) were included. Tests were selected and receiver operating characteristic curves were generated relative to the performance of 780 controls from the GREFEX study. Stepwise logistic regression identified 3 cognitive tests (Six Elements Task, categorical fluency and Trail Making Test B error) and behavioral disorders globally referred as global hypoactivity (P=0.0001, all). This shortened battery was as accurate as the entire GREFEX battery in diagnosing dysexecutive disorders in both training group and the validation group. Bootstrap procedure confirmed the stability of AUC. A shortened battery based on 3 cognitive tests and 3 behavioral domains provides a high diagnosis accuracy of executive disorders in mild-to-moderate AD.
Departments of *Neurology, Laboratory of Functional Neurosciences#Biostatistics, University Hospital of Amiens, Amiens†Department of Neurology, Rouen University Hospital, Rouen‡Geriatric Center, CMRR, Pitié-Salpêtrière University Hospital (AP-HP and UPMC)∥Department of Gerontology, Research Team EA4468, Broca Hospital**Novartis Pharma SAS, Paris§Department of Neurology, CMRR, University Hospital of Grenoble, Grenoble¶Department of Neurology, General Hospital of Cholet, Cholet††Department of Neurology, University Hospital of Reims, Reims‡‡Office of Neurology, Bergerac, France.
Olivier
O
Godefroy
Olivier
O
Martinaud
Marc
M
Verny
Chrystèle
C
Mosca
Hermine
H
Lenoir
Eric
E
Bretault
Agnès
A
Devendeville
Momar
M
Diouf
Jean-Jacques
JJ
Pere
Serge
S
Bakchine
Jean-Philippe
JP
Delabrousse-Mayoux
Martine
M
Roussel
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D015233:Models, Statistical; D009483:Neuropsychological Tests / Q000592:standards / Q000706:statistics & numerical data; D015203:Reproducibility of Results