MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis.
Oral cancer, represented mainly by oral squamous cell carcinoma (OSCC), is the eighth most common type of human cancer worldwide. The number of new OSCC cases is increasing worldwide, especially in the low-income countries, and the prognosis remains poor in spite of recent advances in the diagnostic and therapeutic modalities. MicroRNAs (miRNAs), 18-25 nucleotides long noncoding RNA molecules, have recently gained significant attention as potential regulators and biomarkers for carcinogenesis. Recent data show that several miRNAs are deregulated in OSCC, and they have either a tumor suppressive or an oncogenic role in oral carcinogenesis. This review summarizes current knowledge on the role of miRNAs as tumor promotors or tumor suppressors in OSCC development and discusses their potential value as diagnostic and prognostic markers in OSCC.
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, China.
Anjie
A
Min
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, China ; School of Stomatology, Central South University, Changsha, China.
Chao
C
Zhu
Cancer Research Institute, Central South University, Changsha, China.
Shuping
S
Peng
The Gade Laboratory for Pathology, Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Centre for Cancer Biomarkers (CCBIO), Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway.
Saroj
S
Rajthala
The Gade Laboratory for Pathology, Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Centre for Cancer Biomarkers (CCBIO), Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway.
Daniela Elena
DE
Costea
The Gade Laboratory for Pathology, Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Centre for Cancer Biomarkers (CCBIO), Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway ; Department of Oncology and Medical Physics, Haukeland University Hospital, 5021 Bergen, Norway.
Dipak
D
Sapkota
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism*; D019317:Evidence-Based Medicine; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D000077195:Squamous Cell Carcinoma of Head and Neck
D014408:Biomarkers, Tumor; D035683:MicroRNAs