LOW BONE MINERAL DENSITY IN BRAZILIAN PATIENTS AT DIAGNOSIS OF CELIAC DISEASE.
BACKGROUND
Low bone mineral density is considered an extra-intestinal manifestation of celiac disease with reduced bone mass, increased bone fragility, and risk of fractures. Celiac disease is considered a condition at high risk for secondary osteoporosis and the evaluation of bone density is very important in the clinical management of these patients.


OBJECTIVE
The present study aimed to investigate bone alterations in celiac patients from Curitiba, South Region of Brazil at diagnosis, correlating the findings with age and gender.


METHODS
Patients who were included in the study were attended to in a private office of the same physician from January 2009 to December 2013. The diagnosis of celiac disease was done through clinical, serological and histological findings. All data were collected from the medical charts of the patients. After the diagnosis of celiac disease, evaluation for low bone mineral density was requested by dual-energy X-ray absorptiometry (DEXA). DEXA bone densitometer was used to estimate low bone mineral density at the lumbar spine and femur.


RESULTS
A total of 101 patients, 82 (81.2%) female and 19 (18.8%) male subjects, with mean age of 39.0±3.03 years were included. At celiac disease diagnosis, 36 (35.6%) were younger than 30 years, 41 (40.6%) were between 31 and 50 years, and 24 (23.8%) were older than 50 years. Among the evaluated patients, 69 (68.3%) presented low bone mineral density, being 47% with osteopenia and 32% with osteoporosis. Patients who were older than 51 years and diagnosed with celiac disease presented low bone mineral density in 83.3% (20/24) of the cases. As expected, age influenced significantly the low bone mineral density findings. Among women, low bone mineral density was present with high frequency (60%) from 30 to 50 years. In patients diagnosed older than 60 years (n=8), all the women (n=5) and two of the three men had osteoporosis.


CONCLUSIONS
This study demonstrated that 69% of Brazilian patients with celiac disease at diagnosis had low bone mineral density, being more frequent in women older than 50 years.
Serviço de Gastroenterologia, Hospital Cajuru, Pontifícia Universidade Católica do Paraná, Curitiba, PR, BR.
Joyce Timmermans Pires da
JT
Silva
Departamento de Medicina, Universidade Positivo, Curitiba, PR, BR.
Renato M
RM
Nisihara
Serviço de Gastroenterologia, Hospital Cajuru, Pontifícia Universidade Católica do Paraná, Curitiba, PR, BR.
Luís Roberto
LR
Kotze
Serviço de Gastroenterologia, Hospital Cajuru, Pontifícia Universidade Católica do Paraná, Curitiba, PR, BR.
Márcia
M
Olandoski
Serviço de Gastroenterologia, Hospital Cajuru, Pontifícia Universidade Católica do Paraná, Curitiba, PR, BR.
Lorete Maria da Silva
LM
Kotze
D015502:Absorptiometry, Photon; D000328:Adult; D000367:Age Factors; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000209:etiology*; D001938:Brazil; D002446:Celiac Disease / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D005269:Femur; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000209:etiology*; D012307:Risk Factors; D012737:Sex Factors