Association of serum cotinine levels and the parameters of vascular structure and function in never-smoking adults.
Passive smoking is now recognized to be associated with early arterial damage. The aim of this study was to assess the relationship between secondhand smoke (SHS) exposure, measured objectively by serum cotinine level, and the parameters used to assess vascular structure and function among never smokers in North China. From January 2008 to August 2008, 652 adults aged 20-70 years were enrolled. Brachial-ankle pulse wave velocity (baPWV), ankle-brachial index, and carotid intima-media thickness measurements were performed in all patients. All participants were required to respond to an interviewer-led questionnaire including medical histories and demographic data and to receive blood tests on biochemical indicators. We found that in nonsmokers, higher levels of serum cotinine were positively associated with higher baPWV and brachial pulse pressure after adjusting for heart rate, body mass index, and other confounders. Tests for linear trends for this association were statistically significant. In contrast, no association was present with ankle-brachial index and carotid intima-media thickness. In never smokers, higher SHS exposure measured objectively by serum cotinine levels was found to be associated with brachial pulse pressure and baPWV after adjusting for confounders.
Department of Community Health and Prevention, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, People's Republic of China. Electronic address: wang-jin-wen@163.com.
Jin-Wen
JW
Wang
Department of Cardiology, People's Hospital of Peking University, Beijing, People's Republic of China.
Da-Yi
DY
Hu
D000328:Adult; D000367:Age Factors; D055109:Ankle Brachial Index; D001783:Blood Flow Velocity; D015992:Body Mass Index; D059168:Carotid Intima-Media Thickness / Q000706:statistics & numerical data*; D003367:Cotinine / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D018570:Risk Assessment; D012737:Sex Factors; D011795:Surveys and Questionnaires; D013624:Taiwan; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D018084:Ultrasonography, Interventional; D055815:Young Adult
D014028:Tobacco Smoke Pollution; D003367:Cotinine
Arterial stiffness; risk factor; secondhand smoke