Pontemazines A and B, phenazine derivatives containing a methylamine linkage from Streptomyces sp. UT1123 and their protective effect to HT-22 neuronal cells.
New phenazine derivatives with a methylamine linker, Pontemazines A (1) and B (2), were isolated from the culture broth of Streptomyces sp. UT1123. The structures of compounds 1 and 2 were determined by NMR spectroscopy and high-resolution mass spectrometry. These compounds consist of a 9-mehoxyphenazine connected to a benzamide functional group by a unique methylamine linker instead of the more common methyl ether. Pontemazines A and B possess a neuronal cell protective effect on glutamate-induced mouse hippocampal HT-22 cell damage.
Natural Product Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do 210-340, Republic of Korea.
Jin Wook
JW
Cha
Natural Product Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do 210-340, Republic of Korea.
Seung Il
SI
Lee
Natural Product Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do 210-340, Republic of Korea.
Min Cheol
MC
Kim
Natural Product Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do 210-340, Republic of Korea.
Mya
M
Thida
Natural Product Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do 210-340, Republic of Korea; Department of Biological Chemistry, University of Science and Technology, Daejun 305-350, Republic of Korea.
Jae Wook
JW
Lee
Natural Product Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do 210-340, Republic of Korea.
Jin-Soo
JS
Park
Natural Product Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do 210-340, Republic of Korea. Electronic address: hkwon@kist.re.kr.
Hak Cheol
HC
Kwon
D000818:Animals; D002460:Cell Line; D018698:Glutamic Acid / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010619:Phenazines / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*
D018696:Neuroprotective Agents; D010619:Phenazines; C000609662:pontemazine A; C000609663:pontemazine B; D018698:Glutamic Acid
Methylamine linkage; Neuroprotection; Phenazine; Pontemazines; Streptomyces