Bacterial backstabbing: EF-Tu, brute?
Bacterial type VI secretion is an offensive and defensive weapon that utilizes a molecular warhead to inject toxins into neighboring cells. In this issue of Cell, Whitney et al. report a new class of toxin that disrupts the core metabolism of recipient cells and uncover a surprising requirement for EF-Tu.
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Matthew T
MT
Cabeen
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: losick@mcb.harvard.edu.
Richard
R
Losick
D001427:Bacterial Toxins / Q000378:metabolism*; D009244:NAD+ Nucleosidase / Q000378:metabolism*; D010444:Peptide Elongation Factor Tu / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D000069376:Type VI Secretion Systems / Q000737:chemistry*
D001427:Bacterial Toxins; D000069376:Type VI Secretion Systems; D009244:NAD+ Nucleosidase; D010444:Peptide Elongation Factor Tu