From actomyosin oscillations to tissue-level deformations.
Pulsatile actomyosin contractility driving cell shape oscillations is a common feature of actomyosin networks present in a variety of tissues undergoing morphogenetic processes. The origin of this oscillatory dynamics, how it is stabilized over time to give rise to net cell shape changes and how it is spatially coordinated across a tissue, are questions that have being extensively investigated in recent years. In this work, I review how genetics, cell biology, and quantitative and theoretical approaches have started to give a comprehensive understanding of these problems revealing that both biochemical and mechanical regulation play an important role in the emergence, coordination and stabilization of this activity.
Centro de Biología Molecular "Severo Ochoa," CSIC-UAM, Madrid, Spain.
Nicole
N
Gorfinkiel
D000205:Actomyosin / Q000378:metabolism*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D006801:Humans; D009024:Morphogenesis / Q000502:physiology*
D000205:Actomyosin
actomyosin oscillations; adhesion; apical contraction; mechanics; morphogenesis; myosin phosphorylation