Lipid profile in acute stroke: A prospective study.
The dramatic decline in the risk of stroke is most likely secondary to a better control of risk factors, especially hypertension. An increase in low-density lipoprotein (LDL) cholesterol or a decrease in high-density lipoprotein (HDL) cholesterol may be additional risk factors for cerebrovascular diseases. In this study, we prospectively evaluated patients with ischemic stroke (except for cardioembolic) and age-matched controls for serum cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, very low-density lipoprotein cholesterol, and apoprotein A and B. Blood levels were determined at least 8 weeks after the acute stroke or transient ischemic attack. Between September 1989 and September 1990,59 patients and 60 controls were investigated. There were no differences among total cholesterol, triglycerides, LDL cholesterol, and apoproteins in the two groups. HDL cholesterol, however, was significantly higher in patients with stroke. In stroke patients, total cholesterol (p < 0.05), LDL cholesterol (p < 0.05), and apolipoprotein B (p < 0.05) were significantly higher in female patients compared to male patients. This study confirms that low HDL cholesterol may be a risk factor for stroke. Additionally, ally, we show that lipid abnormalities may appear to be more significant in women.
From the Department Medicine, Royal University Hospital and College of Medicine, Saskatoon, Saskatchewan, Canada S7N 0X0.; The Department the Saskatchewan Stroke Research Centre, Royal University Hospital and College of Medicine, Saskatoon, Saskatchewan, Canada S7N 0X0.
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Shuaib
The Department Pathology, Royal University Hospital and College of Medicine, Saskatoon, Saskatchewan, Canada S7N 0X0.; The Department the Saskatchewan Stroke Research Centre, Royal University Hospital and College of Medicine, Saskatoon, Saskatchewan, Canada S7N 0X0.
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Kalra
The Department Pathology, Royal University Hospital and College of Medicine, Saskatoon, Saskatchewan, Canada S7N 0X0.
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Prasad
The Department Pathology, Royal University Hospital and College of Medicine, Saskatoon, Saskatchewan, Canada S7N 0X0.
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Mantha
The Department Radiology, Royal University Hospital and College of Medicine, Saskatoon, Saskatchewan, Canada S7N 0X0.
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Wallace