New tricks from an old dog: Another synaptotoxic fragment from APP.
In a surprising twist, a hitherto unrecognized cleavage of the amyloid precursor protein (APP) by η-secretase, followed by α- or β-secretase cleavage releases a novel APP proteolytic fragment, Aη, which causes synaptic injury.
Department of Medicine, National University of Singapore, Singapore.
Sheue-Houy
SH
Tyan
Department of Medicine, National University of Singapore, Singapore.|Department of Neurosciences, University of California San Diego, La Jolla, USA.
Edward H
EH
Koo
D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D005260:Female; D006624:Hippocampus / Q000166:cytology*; D006801:Humans; D008297:Male; D053504:Matrix Metalloproteinases, Membrane-Associated / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D059748:Proteolysis
D016564:Amyloid beta-Protein Precursor; D053829:Amyloid Precursor Protein Secretases; D053504:Matrix Metalloproteinases, Membrane-Associated