GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma.
GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. However, the role of GALNT7 in the development and progression of nasopharyngeal carcinoma (NPC) remains unclear. Our previous study showed that GALNT7 was a putative target of miR-494, which was confirmed by luciferase reporter assay. In the present study, we demonstrated that in vitro knockdown of GALNT7 significantly inhibited the proliferation, colony formation, migration, and invasion of NPC-derived cells. In vivo tumorigenicity assay showed that miR-494 and GALNT7-small interfering RNA (siRNA) reduced tumor growth in nude mice. Taken together, our results provided new evidence for an oncogenic role of GALNT7 in NPC.
Department of Otolaryngological, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China. nghui@21cn.com.
Guo-Hui
GH
Nie
Department of Otolaryngological, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.|Guangzhou Medical University, Guangzhou, 510000, Guangdong, China.
Liang
L
Luo
Department of Otolaryngological, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.
Hong-Fang
HF
Duan
Department of Otolaryngological, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.
Xiao-Qing
XQ
Li
Department of Otolaryngological, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.
Mei-Jun
MJ
Yin
Department of Otolaryngological, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.|Guangzhou Medical University, Guangzhou, 510000, Guangdong, China.
Zhao
Z
Li
Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong, China. zhangweispace@yeah.net.
Wei
W
Zhang
D000818:Animals; D017209:Apoptosis; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D002277:Carcinoma; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics*; D017350:N-Acetylgalactosaminyltransferases / Q000235:genetics* / Q000378:metabolism; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009368:Neoplasm Transplantation; D034622:RNA Interference; D047368:Tumor Burden; D000097763:Polypeptide N-acetylgalactosaminyltransferase
D035683:MicroRNAs; D017350:N-Acetylgalactosaminyltransferases; D000097763:Polypeptide N-acetylgalactosaminyltransferase; C547168:MIRN494 microRNA, human
GALNT7; Nasopharyngeal carcinoma; Oncogenicity; Tumor suppressor; miR-494