Plasma acyl-ghrelin increases after meal initiation: a new insight.
Plasma ghrelin secretion over time in humans is characterized by pre-prandial increases and by post-prandial decreases all day long. However, some authors who measured ghrelin concentrations around meals showed a rise in plasma ghrelin concentration after meal initiation followed by the typical post-prandial decrease. In order to confirm this observation that has never been discussed, we described ghrelin profiles around four eating episodes in the morning in adult men.



Twenty normal-weight and 17 obese men were instructed to eat four fixed meals (706 kJ) 10 min long at 0800 h, 0900 h, 1000 h and 1100 h. Using frequent blood sampling, we determined plasma acyl-ghrelin concentrations around those eating episodes. Glucose, insulin and GLP-1 concentrations were also measured.



The meals consumption induced a significant increase in plasma acyl-ghrelin concentrations 10 min after meal initiation (P<0.0001): +20.9±5.8 and +10.7±3.3 pg/ml in normal-weight and obese subjects for the first meal; +10.4±3.0 and +5.5±3.9 pg/ml in normal-weight and obese subjects for the second meal; +12.4±3.6 and +4.2±2.1 pg/ml in normal-weight and obese subjects for the third meal; and +4.4±4.1 and +3.3±2.61 pg/ml in normal-weight and obese subjects for the fourth meal.



This study is the first to describe and discuss the post-meal initiation ghrelin increase. This finding is consistent in normal-weight and obese individuals.
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Centre Européen Pour la Nutrition et la Santé, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, Faculté de Médecine de Maïeutique Lyon Sud, Pierre-Bénite, France.
K
K
Seyssel
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Centre de Recherche de l'Institut Paul Bocuse, Château du Vivier, Ecully, France.
X
X
Allirot
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Centre Européen Pour la Nutrition et la Santé, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, Faculté de Médecine de Maïeutique Lyon Sud, Pierre-Bénite, France.
J-A
JA
Nazare
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Poôe Recherche, CHU Grenoble, INSERM U1055-Bioénergétique, Université Grenoble Alpes, Grenoble, France.
H
H
Roth
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Centre Européen Pour la Nutrition et la Santé, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Laboratoire de Biochimie du Centre Hospitalier Lyon Sud HCL, Pierre-Bénite, France.
E
E
Blond
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Centre Européen Pour la Nutrition et la Santé, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, Faculté de Médecine de Maïeutique Lyon Sud, Pierre-Bénite, France.|Laboratoire de Biochimie du Centre Hospitalier Lyon Sud HCL, Pierre-Bénite, France.
A
A
Charrié
Laboratoire de Biochimie du Centre Hospitalier Lyon Sud HCL, Pierre-Bénite, France.
A
A
Mialon
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Centre Européen Pour la Nutrition et la Santé, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, Faculté de Médecine de Maïeutique Lyon Sud, Pierre-Bénite, France.|Laboratoire de Biochimie du Centre Hospitalier Lyon Sud HCL, Pierre-Bénite, France.
J
J
Drai
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Centre Européen Pour la Nutrition et la Santé, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, Faculté de Médecine de Maïeutique Lyon Sud, Pierre-Bénite, France.
M
M
Laville
Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|Centre Européen Pour la Nutrition et la Santé, Centre Hospitalier Lyon Sud, Pierre Bénite, France.|CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, Faculté de Médecine de Maïeutique Lyon Sud, Pierre-Bénite, France.
E
E
Disse
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004435:Eating / Q000502:physiology*; D005215:Fasting / Q000502:physiology*; D054439:Ghrelin / Q000097:blood*; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D062407:Meals / Q000502:physiology*; D009765:Obesity / Q000097:blood; D019518:Postprandial Period; D012016:Reference Values
D001786:Blood Glucose; D054439:Ghrelin; D007328:Insulin; D052216:Glucagon-Like Peptide 1