[Effect of Three Typical Disinfection Byproducts on Bacterial Antibiotic Resistance].
The effect of typical disinfection byproducts (DBPs) on bacterial antibiotic resistance was investigated in this study. chlorodibromomethane (CDBM), iodoacetic acid (IAA) and chloral hydrate (CH) were selected, which belong to trihalomethanes (THMs), haloacetic acids (HAAs) and aldehydes, respectively. After exposure to the selected DBPs, the resistance change of the tested strains to antibiotics was determined. As a result, all of the three DBPs induced Pseudomonas aeruginosa PAO1 to gain increased resistance to the five antibiotics tested, and the DBPs ranked as IAA > CH > CDBM according to their enhancement effects. Multidrug resistance could also be enhanced by treatment with IAA. The same result was observed in Escherichia coli K12, suggesting that the effect of DBPs on antibiotic resistance was a common phenomenon. The mechanism was probably that DBPs stimulated oxidative stress, which induced mutagenesis. And the antibiotic resistance mutation frequency could be increased along with mutagenesis. This study revealed that the acquisition of bacterial antibiotic resistance might be related to DBPs in drinking water systems. Besides the genotoxicological risks, the epidemiological risks of DBPs should not be overlooked.
Lu
L
Lü
Meng-lu
ML
Zhang
Chun-ming
CM
Wang
Hui-rong
HR
Lin
Xin
X
Yu
D000900:Anti-Bacterial Agents; D002697:Chloral Hydrate / Q000737:chemistry; D004202:Disinfectants / Q000737:chemistry*; D004203:Disinfection; D060766:Drinking Water; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D019807:Iodoacetic Acid / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics; D022882:Trihalomethanes / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000737:chemistry*; D018508:Water Purification
D000900:Anti-Bacterial Agents; D004202:Disinfectants; D060766:Drinking Water; D022882:Trihalomethanes; D014874:Water Pollutants, Chemical; C032707:chlorodibromomethane; D002697:Chloral Hydrate; D019807:Iodoacetic Acid