TADDOL-based phosphorus(III)-ligands in enantioselective Pd(0)-catalysed C-H functionalisations.
Monodentate TADDOL-derived phosphoramidites and phosphonites are versatile chiral ligands for enantioselective Pd(0)-catalysed C-H functionalisations. They enable highly selective cyclisations to access a wide range of chiral carbo- and heterocycles. The high attractiveness of this ligand class consists in their modular structure, allowing for a quick assembly of a library with variable steric properties. Asymmetric C-H functionalisation methods utilising catalytic systems based on Pd(0) complexes and TADDOL-type ligands are presented and aspects of selectivity are discussed.
Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC LCSA, BCH 4305, CH-1015 Lausanne, Switzerland. nicolai.cramer@epfl.ch.
Julia
J
Pedroni
Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC LCSA, BCH 4305, CH-1015 Lausanne, Switzerland. nicolai.cramer@epfl.ch.
Nicolai
N
Cramer