Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum.
The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies.
School of Pharmacy, 97 Lisburn Road, Queens University Belfast, Belfast BT9 7BL, Northern Ireland, UK. azaidalkilani01@qub.ac.uk.|Faculty of Pharmacy, Zarqa University, Zarqa 132222, Jordan. azaidalkilani01@qub.ac.uk.
Ahlam Zaid
AZ
Alkilani
School of Pharmacy, 97 Lisburn Road, Queens University Belfast, Belfast BT9 7BL, Northern Ireland, UK. m.mccrudden@qub.ac.uk.
Maelíosa T C
MT
McCrudden
School of Pharmacy, 97 Lisburn Road, Queens University Belfast, Belfast BT9 7BL, Northern Ireland, UK. R.Donnelly@qub.ac.uk.
Ryan F
RF
Donnelly
drug delivery; mechanical and electrical approaches; microneedle; thermal ablation; transdermal; ultrasound; velocity based device