Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia.
Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by a subacute course and favorable prognosis with corticosteroids. However, some patients show resistance to steroids. Macrolides have been used with success in those patients showing resistance to steroids. A few reports showed treatment failure with macrolides in patients with COP who were resistant to steroids. In this report, we described two cases of COP who showed different responses to clarithromycin. One recovered completely, but the other gradually showed lung fibrosis with clarithromycin.
Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
Ji Hyun
JH
Oh
Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
Dong Jun
DJ
Oh
Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
So-My
SM
Koo
Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
Yang Ki
YK
Kim
Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
Ki Up
KU
Kim
Department of Thoracic Surgery, Soonchunhyang University Hospital, Seoul, Korea.
Hyun Jo
HJ
Kim
Department of Pathology, Soonchunhyang University Hospital, Seoul, Korea.
Dong Won
DW
Kim
Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
Soo-Taek
ST
Uh
Adrenal Cortex Hormones; Clarithromycin; Cryptogenic Organizing Pneumonia; Macrolides