[THE ROLE OF ADIPOCYTOKINES IN THE FORMATION OF INSULIN RESISTANCE IN PATIENTS WITH PRIMARY HYPOTHYROIDISM].
The aim of the study was to investigate the levels of adiponectin and indexes of insulin resistance in patients with primary hypothyroidism. In this article published data and personal data about the role of adiponectin in formation insulin resistance in patients with primary hypothyroidism are shown. The study involved 72 patients with primary hypothyroidism. arising on the background of endemic goiter, including 42 women and 30 men. A direct linear correlation between indexes HOMA IR and TSH was established. We found significantly lower levels of adiponectin in all patients with manifest and subclinical hypothyroidism compared with the control group. Low levels of adiponectin may be an independent factor in the development of insulin resistance in hypothyroidism, cardiovascular diseases and can be considered to be the marker of hypothyroidism with components of metabolic syndrome.
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Vatseba
D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood; D055105:Waist Circumference
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D013972:Thyrotropin