[Randomness and cell fate].
Thermal fluctuations at the molecular scale cause random fluctuations of gene expression, which, in association with differentiation circuits, can lead to phenotypic diversification in cell populations. In this synthesis article, we detail the mechanisms that generate this diversification and illustrate their consequences in various organisms. In bacteria, random phenotypic diversification allows to anticipate environmental changes that are otherwise unpredictable, in particular during metabolic transitions and stress responses, for example inducing a transient form of antibiotic resistance. In multi-cellular organisms, similar mechanisms allow the maintenance of healthy tissues, such as intestinal crypts, epidermis and retina, but also seem to play a role in establishment and renewal of tumoral heterogeneity.
École supérieure de physique et chimie industrielle (ESPCI), laboratoire de biochimie, 10, rue Vauquelin, 75005 Paris, France.
Philippe
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D000818:Animals; D001419:Bacteria / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics*; D060833:Cellular Microenvironment / Q000235:genetics; D015870:Gene Expression / Q000502:physiology*; D059647:Gene-Environment Interaction; D014644:Genetic Variation; D006801:Humans; D010641:Phenotype; D011336:Probability; D013696:Temperature