Cancer 2015: a longitudinal whole-of-system study of genomic cancer medicine.
Genomic cancer medicine promises revolutionary change in oncology. The impacts of 'personalized medicine', based upon a molecular classification of cancer and linked to targeted therapies, will extend from individual patient outcomes to the health economy at large. To address the 'whole-of-system' impact of genomic cancer medicine, we have established a prospective cohort of patients with newly diagnosed cancer in the state of Victoria, Australia, about whom we have collected a broad range of clinical, demographic, molecular, and patient-reported data, as well as data on health resource utilization. Our goal is to create a model for investigating public investment in genomic medicine that maximizes the cost:benefit ratio for the Australian community at large.
The Kinghorn Cancer Centre and Cancer Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. Electronic address: d.thomas@garvan.org.au.
David M
DM
Thomas
Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia; Department of Pathology, University of Melbourne, Melbourne, VIC, Australia; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Stephen
S
Fox
Centre for Health Economics, Monash School of Business, Monash University, Clayton, VIC, Australia.
Paula K
PK
Lorgelly
Andrew Love Cancer Centre, Barwon Health, School of Medicine, Deakin University, Geelong, VIC, Australia.
David
D
Ashley
Cabrini Institute, Malvern, Melbourne, VIC, Australia.
Gary
G
Richardson
Royal Melbourne Hospital, Parkville, VIC, Australia.
Lara
L
Lipton
Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia; Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
John P
JP
Parisot
School of Public Health & Preventive Medicine, Department of Epidemiology & Preventive Medicine, Monash Faculty of Medicine Nursing & Health Sciences, Alfred Hospital, Prahran,, Melbourne, VIC, Australia.
Mark
M
Lucas
School of Public Health & Preventive Medicine, Department of Epidemiology & Preventive Medicine, Monash Faculty of Medicine Nursing & Health Sciences, Alfred Hospital, Prahran,, Melbourne, VIC, Australia.
John
J
McNeil
Michael
M
Wright
D001315:Australia; D023281:Genomics / Q000379:methods; D006801:Humans; D008137:Longitudinal Studies; D008511:Medicine / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D057285:Precision Medicine / Q000379:methods; D011446:Prospective Studies