Carcinosarcoma with Choriocarcinomatous and Osteosarcomatous Differentiation in a Patient with Juvenile Polyposis Syndrome.
Juvenile polyposis syndrome (JPS) is an infrequent autosomal dominant hereditary predisposition to the occurrence of hamartomatous polyps in the colon and rectum. We describe the case of a 12-year-old boy with JPS associated with an abdominal tumor. Histological sections of the abdominal tumor showed components of adenocarcinoma, osteosarcoma, and choriocarcinoma. Immunohistochemistry was AE1/AE3, CK7, HCG and SALL4 positive. Juvenile polyposis syndrome patients are at increased risk of colorectal adenocarcinoma. However, we present a case of an adenocarcinoma associated with other unusual components. This association has not been reported before.
Department of Pathology, Hospital Infantil de San José , Bogotá, Colombia ; Fundación Universitaria de Ciencias de la Salud , Bogotá, Colombia.
Rafael
R
Parra-Medina
Department of Pathology, Hospital Infantil de San José , Bogotá, Colombia ; Fundación Universitaria de Ciencias de la Salud , Bogotá, Colombia.
Patricia López
PL
Correa
Fundación Universitaria de Ciencias de la Salud , Bogotá, Colombia.
Julian Jiménez
JJ
Moreno
Fundación Universitaria de Ciencias de la Salud , Bogotá, Colombia.
Paula Moreno
PM
Lucero
Department of Pathology, Hospital Infantil de San José , Bogotá, Colombia ; Fundación Universitaria de Ciencias de la Salud , Bogotá, Colombia.
Edgardo
E
Yaspe
Department of Pathology, Hospital Infantil de San José , Bogotá, Colombia ; Fundación Universitaria de Ciencias de la Salud , Bogotá, Colombia.
Fernando
F
Polo
Juvenile polyposis syndrome; adenocarcinoma; choriocarcinoma; osteosarcoma