Dengue epidemiology and pathogenesis: images of the future viewed through a mirror of the past.
Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs.
Bio-Resources Technology and Industrial Biotechnology Laboratory, Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka, 1342, Bangladesh.
Rashedul
R
Islam
Bio-Resources Technology and Industrial Biotechnology Laboratory, Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka, 1342, Bangladesh.
Mohammed
M
Salahuddin
Bio-Resources Technology and Industrial Biotechnology Laboratory, Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka, 1342, Bangladesh.
Md Salahuddin
MS
Ayubi
Bio-Resources Technology and Industrial Biotechnology Laboratory, Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka, 1342, Bangladesh.
Tahmina
T
Hossain
Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, 9100, Bangladesh.
Apurba
A
Majumder
School of Medical & Applied Sciences, Central Queensland University, Rockhampton, 4701, Australia.
Andrew W
AW
Taylor-Robinson
Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, 9100, Bangladesh. mahmud0907@gmail.com.|Research and Development (R&D) Department, Incepta Vaccine Limited, Zirabo, Savar, Dhaka, 1341, Bangladesh. mahmud0907@gmail.com.
Abdullah
A
Mahmud-Al-Rafat
D000818:Animals; D003715:Dengue / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control; D053059:Dengue Vaccines / Q000008:administration & dosage; D003716:Dengue Virus / Q000472:pathogenicity; D004195:Disease Models, Animal; D006801:Humans; D008018:Life Cycle Stages; D051379:Mice
D053059:Dengue Vaccines
animal model; anti-viral; dengue; dengue vaccine; epidemiology; pathogenesis; vector control