High levels of impulsivity in rats are not accompanied by sensorimotor gating deficits and locomotor hyperactivity.
High levels of impulsivity have been linked to a number of psychiatric disorders, including attention-deficit/hyperactivity disorder, drug abuse and schizophrenia. Additionally, schizophrenia patients commonly show deficits in another rather preattentive form of response inhibition, called sensorimotor gating. Given that higher-order functions, such as impulse control, are protected by early and preattentive processes, disturbed gating mechanisms may hamper more complex cognitive-executive functions. In the present study, we therefore tested whether high levels of impulsivity are accompanied by impaired sensorimotor gating in rats. High (HI) and low impulsive (LI) rats were identified based on the number of premature responses in the 5-choice serial reaction time task. Here, LI rats showed higher numbers of omission errors which may suggest attentional deficits while HI rats completed significantly less trials which could indicate a decrease in motivation. However, HI and LI rats did not differ in terms of impulsive decision-making in a delay-based decision-making T-maze task, prepulse inhibition of the acoustic startle response (a measure of sensorimotor gating mechanisms) or locomotor activity levels. Overall, our data indicate that high motor impulsivity is not a suitable predictor of deficient sensorimotor gating and is further not necessarily associated with attentional deficits and/or locomotor hyperactivity in rats.
Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
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Feja
Department of Neuropharmacology, Center for Cognitive Science, University of Bremen, Bremen, Germany.
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Lang
Department of Neuropharmacology, Center for Cognitive Science, University of Bremen, Bremen, Germany.
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Deppermann
Department of Neuropharmacology, Center for Cognitive Science, University of Bremen, Bremen, Germany.
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Yüksel
Department of Neuropharmacology, Center for Cognitive Science, University of Bremen, Bremen, Germany. Electronic address: wischhof@uni-bremen.de.
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Wischhof
D000161:Acoustic Stimulation; D000818:Animals; D002755:Choice Behavior / Q000502:physiology; D006948:Hyperkinesis / Q000473:pathology; D007175:Impulsive Behavior / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D065808:Prepulse Inhibition / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology; D013216:Reflex, Startle / Q000502:physiology; D055139:Sensory Gating / Q000502:physiology*
Attention; Impulsivity; Locomotor activity; Rat; Sensorimotor gating