The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan-Anseong) cohort.
BACKGROUND
Dietary antioxidants have been suggested to have protective role against chronic obstructive pulmonary disease (COPD), but few prospective studies examined this relationship. The prospective study was conducted to evaluate the effect of dietary antioxidants on COPD risk and lung function in the Korean population.


METHODS
The data were collected from the community-based Korean Genome Epidemiology Study (KoGES) cohort. To diagnose COPD, forced expiratory volume (FEV1) and forced vital capacity (FVC) were measured by spirometry. The dietary intake of antioxidant vitamins was estimated from validated Food-Frequency Questionnaire. For the analysis, 325 COPD patients and 6,781 at risk subjects were selected from the cohort of 10,038 subjects. Multiple logistic regression models were used to examine the odds ratio (OR) after adjusting for age, sex, marital status, income, history of asthma, history of tuberculosis, and smoking.


RESULTS
The risk of COPD was positively associated with aging, low education, low household income, lower body mass index, and cigarette smoking. The risk of COPD decreased with increase in the dietary vitamin C (ORQ1 vs Q5=0.66, P trend=0.03) and vitamin E (ORQ1 vs Q5=0.56, P trend=0.05) intake, predominantly, in men (P trend=0.01 and 0.05 for vitamins C and E, respectively). In addition, the lung function was significantly improved with increase in vitamins C (FEV1, P=0.04; FVC, P=0.03) and E (FEV1, P=0.03; FVC, P=0.04) intake. No statistically significant interactions were observed between smoking and vitamin C or E intake in relation to COPD risk among men.


CONCLUSIONS
Our results suggest the independent beneficial effect of antioxidants, particularly vitamins C and E, on COPD risk and lung function in men.
Department of Preventive Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea ; BIT Medical Convergence Graduate Program, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea.
Pankaj
P
Joshi
Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea ; Environmental Health Center, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea.
Woo Jin
WJ
Kim
Department of Preventive Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea ; BIT Medical Convergence Graduate Program, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea ; Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea.
Sang-Ah
SA
Lee
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology*; D005247:Feeding Behavior / Q000502:physiology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065840:Protective Factors; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control / Q000523:psychology; D056910:Republic of Korea / Q000453:epidemiology; D012129:Respiratory Function Tests / Q000379:methods; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D014815:Vitamins / Q000494:pharmacology*
D000975:Antioxidants; D014815:Vitamins
antioxidant vitamins intake; chronic obstructive pulmonary disease (COPD); lung function; smoking; the combined effect of smoking and antioxidant vitamins