Exposure to Metals Can Be Therapeutic.
Because of the widespread epigenetic changes ensuing from carcinogenesis, structural and chemical features of chromatin provide unique targets for developing safer and more effective anticancer drugs. Metal-based agents have a potential advantage over other small molecular species in that characteristics of coordination geometry, redox state and ligand exchange allow one to fine-tune reactivity and affinity properties in a distinct fashion. This intersection of chromatin biology and bioinorganic medicinal chemistry is the subject of multiple collaborations in and between Switzerland and Singapore.
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551. davey@ntu.edu.sg.
Curt A
CA
Davey
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000266:history / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000266:history* / Q000295:instrumentation / Q000379:methods; D002843:Chromatin / Q000187:drug effects / Q000648:ultrastructure; D002945:Cisplatin / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry / Q000266:history / Q000494:pharmacology; D018360:Crystallography, X-Ray; D018736:DNA Adducts / Q000737:chemistry* / Q000648:ultrastructure; D049674:History, 21st Century; D006801:Humans; D007391:International Cooperation; D008670:Metals / Q000737:chemistry*; D009369:Neoplasms / Q000737:chemistry* / Q000188:drug therapy; D010084:Oxidation-Reduction; D012846:Singapore; D013557:Switzerland
D000970:Antineoplastic Agents; D002843:Chromatin; D056831:Coordination Complexes; D018736:DNA Adducts; D008670:Metals; D002945:Cisplatin