Impact of IL-8-251A/T gene polymorphism on severity of disease caused by enterovirus 71 infection.
The study was performed in EV71-infected patients, with 97 mild cases and 80 severe cases. IL-8251A/T genotypes were determined by the polymerase chain reaction restriction fragment length polymorphism technique. Severe cases had a significantly higher frequency of the IL8-251 AT and TT genotypes than mild cases (52.5 % vs. 49.5 % and 42.5 % vs. 30.9 %, respectively; p = 0.024). The frequency of IL-8-251T alleles among the severe cases was also significantly higher than that of mild cases (68.7 % vs. 55.7 %, OR = 1.8, 95 % CI = 1.1-2.7, p = 0.012). There were significant differences in gender, age, fever days, WBC, CRP and BG concentration, and IL-8 levels among genotypes of IL-8251A/T in EV71-infected patients, but there were no significant differences in ALT, AST, CK-MB and EV71 loads. These findings suggested that the IL-8-251T allele is associated with susceptibility to severe disease in Chinese patients infected with EV71.
Infectious Diseases Department, Qilu Children's Hospital of Shandong University, No. 23976 Jingshi Road, Jinan, 250022, People's Republic of China.
Daoyan
D
Xu
Infectious Diseases Department, Qilu Children's Hospital of Shandong University, No. 23976 Jingshi Road, Jinan, 250022, People's Republic of China. hpylijian@hotmail.com.
Jian
J
Li
Shandong Medical College, Jinan, 250002, Shandong, People's Republic of China.
Xiangjuan
X
Huang
Infectious Diseases Department, Qilu Children's Hospital of Shandong University, No. 23976 Jingshi Road, Jinan, 250022, People's Republic of China.
Aiwei
A
Lin
Infectious Diseases Department, Qilu Children's Hospital of Shandong University, No. 23976 Jingshi Road, Jinan, 250022, People's Republic of China.
Zhongtao
Z
Gai
Pediatric Department of the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266003, People's Republic of China.
Zongbo
Z
Chen
D044466:Asian People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D029821:Enterovirus A, Human / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000235:genetics* / Q000821:virology; D006801:Humans; D007223:Infant; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
D016209:Interleukin-8