Sialic acids in biological and therapeutic processes: opportunities and challenges.
It is now well documented that carbohydrates play multiple roles in biological processes, and hence are interesting targets for chemical biology and medicinal chemistry programs. This review focuses on a subset of carbohydrates, specifically sialic acid containing carbohydrates. It highlights their occurrence and diversity, and presents evidence for their roles in a range of biological pathways. It illustrates that they are targets for novel medicinal chemistry strategies for a range of therapeutic areas, including cancer and immunity. Case studies highlight opportunities and challenges in this area, and sialic acid-based drugs that have entered clinical practice and are promising candidates for future disease intervention schemes, are discussed. The review concludes by highlighting perspectives and emerging roles for these targets.
Reading School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
Julia
J
Bauer
Reading School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
Helen M I
HM
Osborn
D000818:Animals; D002241:Carbohydrates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D055808:Drug Discovery; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism* / Q000627:therapeutic use*
D002241:Carbohydrates; D012794:Sialic Acids