Back to sinus rhythm from atrial flutter or fibrillation: dabigatran is safe without transoesophageal control.
OBJECTIVE
To assess the safety of dabigatran in converting persistent atrial fibrillation (PAF) and atrial flutter (AFL) to sinus rhythm (SR) without transoesophageal echocardiography (TEE) evaluation.


METHODS
Consecutive patients with PAF or AFL were included between 2012 and 2015. Dabigatran was used for three weeks before and six months after cardioversion. Left atrium area (LAA) and left atrium volume (LAV) were assessed in all patients. Follow-up visits for major cardiac events occurred at 1, 3, 6, and 12 months.


RESULTS
The study included 82 patients (56 male, mean age 63.1 ± 10.4 years), of which 45 had PAF and 37 AFL. In patients with PAF, mean LAA was 30.3 ± 5.3 cm2 and LAV 114.4 ± 31.5 mL; in those with AFL mean LAA was 26.5 ± 4.2 cm2 and LAV 97 ± 24.9 mL at baseline. Forty-nine patients underwent uncomplicated electric cardioversion (38 with PAF and 11 with AFL), 11 patients were pharmacologically converted to SR (7 with PAF and 4 with AFL), and 22 patients with AFL underwent successful radiofrequency ablation. The mean CHA2DS2-VASc score was 2.96 ± 1.39 (score > 3, 58.6%). No major cardiac events occurred during the follow-up period of 19.4 ± 9.5 months.


CONCLUSIONS
Safe cardioversion using dabigatran was achieved in this small group of patients without the need for TEE.
Dragos
D
Cozma
Universitatea de Medicina si Farmacie "Victor Babes" Timisoara, Romania. cstreian@cardiologie.ro.
Caius Glad
CG
Streian
Cristina
C
Vacarescu
Cristian
C
Mornos
D000368:Aged; D001281:Atrial Fibrillation / Q000188:drug therapy*; D001282:Atrial Flutter / Q000188:drug therapy*; D000069604:Dabigatran / Q000627:therapeutic use*; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061214:Patient Safety; D012189:Retrospective Studies; D016896:Treatment Outcome
D000069604:Dabigatran
atrial flutter or fibrillation; dabigatran; transoesophageal echocardiography