Polymorphisms of RAD50, IL33 and IL1RL1 are associated with atopic asthma in Chinese population.
Genetic architecture of asthma remains obscure. This study aimed to investigate whether the genetic polymorphisms of CDHR3 (rs6967330), GSDMB (rs2305480), IL33 rs928413, RAD50 (rs6871536) and IL1RL1 (rs1558641) are associated with the development of atopic asthma in Chinese population. Genotype and allele frequencies were compared between 516 patients and 552 controls by Chi-square test. Patients were found to have significantly higher allele G of rs928413 and allele C of rs6871536 (9.5% vs 6.2%, P = 0.004 for rs928413; 26.1% vs 19.9%, P < 0.001 for rs6871536). Besides, patients were found to have significantly lower frequency of allele A of rs1558641 (17.2% vs 21.7%, P = 0.007). This is the first study validating that IL33, IL1R1, and RAD50 genes are associated with the risk of asthma in Chinese population.
Department of Paediatrics, Jiangsu Taizhou People's Hospital, Taizhou, China.
J
J
Chen
Department of Gastroenterology, Jiangsu Taizhou People's Hospital, Taizhou, China.
J
J
Zhang
Department of Paediatrics, Jiangsu Taizhou People's Hospital, Taizhou, China.
H
H
Hu
Department of Paediatrics, Jiangsu Taizhou People's Hospital, Taizhou, China.
Y
Y
Jin
Department of Paediatrics, Jiangsu Taizhou People's Hospital, Taizhou, China.
M
M
Xue
D017766:Acid Anhydride Hydrolases; D000293:Adolescent; D000483:Alleles; D000485:Allergens / Q000009:adverse effects; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D000070585:Cadherin Related Proteins; D015820:Cadherins / Q000235:genetics*; D002648:Child; D002681:China / Q000453:epidemiology; D045643:DNA Repair Enzymes / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005541:Forced Expiratory Volume; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33 / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics*; D000094524:Gasdermins
D017766:Acid Anhydride Hydrolases; D000485:Allergens; D000070585:Cadherin Related Proteins; D015820:Cadherins; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins; D007073:Immunoglobulin E; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface; C586717:CDHR3 protein, human; C527978:GSDMB protein, human; D000094524:Gasdermins; C079241:IL1RL1 protein, human; C506536:IL33 protein, human; C112158:RAD50 protein, human
Chinese population; asthma; polymorphism