Case report of primary splenic angiosarcoma with hepatic metastases.
Primary splenic angiosarcoma (PSA) is the most unusual type of malignancy with early multifocal metastasis through hematogenous spread. PSA is generally believed to originate from splenic sinusoidal vascular endothelium with a high rate of metastasis and to have a poor prognosis. Its etiology and pathogenetic mechanisms have not yet been clearly described. Thus far, only approximately 200 cases have been reported. PSA has variable symptomatology with the potential to present with life-threatening complications. The diagnosis of PSA is challenging; and often late. PSA should be considered in the differential diagnosis of patients with splenomegaly and anemia of unknown etiology. Surgical treatment with splenectomy is considered the only curative intervention for potential long-term disease-free survival. Early diagnosis and treatment are very important. It is important that clinical doctors improve the understanding of PSA. Herein, we report one rare case of PSA with hepatic metastases, along with a review of the current literature.
Fang Chen, Hai-Feng Jin, Yi-Hong Fan, Li-Jun Cai, Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China.
Fang
F
Chen
Fang Chen, Hai-Feng Jin, Yi-Hong Fan, Li-Jun Cai, Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China.
Hai-Feng
HF
Jin
Fang Chen, Hai-Feng Jin, Yi-Hong Fan, Li-Jun Cai, Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China.
Yi-Hong
YH
Fan
Fang Chen, Hai-Feng Jin, Yi-Hong Fan, Li-Jun Cai, Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China.
Li-Jun
LJ
Cai
Fang Chen, Hai-Feng Jin, Yi-Hong Fan, Li-Jun Cai, Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China.
Zhuo-Yi
ZY
Zhang
Fang Chen, Hai-Feng Jin, Yi-Hong Fan, Li-Jun Cai, Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China.
Bin
B
Lv
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood; D001706:Biopsy; D049448:Cholangiopancreatography, Magnetic Resonance; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006394:Hemangiosarcoma / Q000097:blood / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000097:blood / Q000737:chemistry / Q000556:secondary*; D011237:Predictive Value of Tests; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000097:blood / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor
Case report; Hepatic metastases; Primary splenic angiosarcoma; Rupture; Splenectomy