Cobalt(III)-Catalyzed C-H Alkynylation with Bromoalkynes under Mild Conditions.
Expedient cobalt-catalyzed C-H alkynylation was achieved under exceedingly mild reaction conditions. Thus, chelation-assisted direct alkynylations of heteroarenes occurred with 1-bromoalkynes and ample substrate scope. The optimized catalytic system allowed for step-economical C-H functionalizations with a mild base K2CO3 at reaction temperatures as low as 25 °C.
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität , Tammannstraße 2, 37077 Göttingen, Germany.
Nicolas
N
Sauermann
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität , Tammannstraße 2, 37077 Göttingen, Germany.
María J
MJ
González
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität , Tammannstraße 2, 37077 Göttingen, Germany.
Lutz
L
Ackermann