Efficacy and Safety of Liposomal Amphotericin B for the Treatment of Mucosal Leishmaniasis from the New World: A Retrospective Study.
The standard treatment of mucosal leishmaniasis (ML) is pentavalent antimonials, agents with serious adverse effects. Alternative agents include amphotericin B deoxycholate and liposomal amphotericin B. We performed a retrospective study including 29 patients treated with liposomal amphotericin B, most of whom had comorbidities, history of previous treatment of ML, and contraindications to the use of antimonial pentavalent or amphotericin B deoxycholate. We observed a cure rate of 93.1%. Kidney failure was the most important side effect, reported in five patients (17.2%). This study showed a good efficacy and safety profile of liposomal amphotericin B in patients with ML and contraindications to the use of other agents.
Instituto de Infectologia Emílio Ribas, São Paulo, Brazil; Laboratório de Soroepidemiologia (LIM-38 HC-FMUSP), Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, Brazil.
Mirella A
MA
Cunha
Instituto de Infectologia Emílio Ribas, São Paulo, Brazil; Laboratório de Soroepidemiologia (LIM-38 HC-FMUSP), Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, Brazil.
Aline C Q
AC
Leão
Instituto de Infectologia Emílio Ribas, São Paulo, Brazil; Laboratório de Soroepidemiologia (LIM-38 HC-FMUSP), Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, Brazil.
Rita
R
de Cassia Soler
Instituto de Infectologia Emílio Ribas, São Paulo, Brazil; Laboratório de Soroepidemiologia (LIM-38 HC-FMUSP), Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, Brazil jlindoso@usp.br.
José Angelo L
JA
Lindoso
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000666:Amphotericin B / Q000009:adverse effects / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001938:Brazil; D005260:Female; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D007897:Leishmaniasis, Mucocutaneous / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000139:chemically induced; D012189:Retrospective Studies; D016896:Treatment Outcome
D000981:Antiprotozoal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B