Buckysomes: New Nanocarriers for Anticancer Drugs.
Buckysomes, liposome-like vesicles comprised of dendritic C60 subunits that self-assemble into unilamellar vesicles, are unique nanovectors that have utility in drug delivery. We have prepared paclitaxel-embedded buckysomes (PEBs) and examined biodistriubition profiles with commercially available formulations of the drug. As compared to Abraxane, an albumin-bound formulation of paclitaxel, PEBs showed higher tissue accumulation in the liver and the kidney at 45 and 60 minutes and in the lungs at 30 minutes, making them suitable drug-delivery carriers for short-term therapy to the mentioned organs. These buckysomes can be further functionalized to specifically deliver paclitaxel to the tumor site.
Division of Cardiology, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 1881 East Road, Houston, TX 77054, USA.
Delia
D
Danila
Division of Cardiology, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 1881 East Road, Houston, TX 77054, USA.
Eva
E
Golunski
Biomatrica, 5627 Oberlin Drive, San Diego, CA 92121, USA.
Ranga
R
Partha
Graduate Schools of Biomedical Sciences, The University of Texas Health Science Center at Houston, 6767 Bertner Ave, Houston, TX 77030, USA.
Madonna
M
McManus
Department of Anesthesiology, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 7703, USA.
Tina
T
Little
Casscells & Associates, LLC, 7111 Davis Court, McLean, VA 22101, USA.
Jodie
J
Conyers