Effect of Obesity and Leptin Level on Migraineurs.
BACKGROUND
The aim of this study was to analyze the effects of obesity and leptin levels on patients with migraine, and to observe the change of leptin levels in migraineurs.


METHODS
We enrolled 52 migraine patients from the Headache Clinic in Shandong Provincial Hospital into a randomized controlled trial with another 52 age-, sex-, and BMI-matched healthy subjects as controls. Leptin levels in all subjects were determined by radioimmunoassay.


RESULTS
Compared with the control group, the migraineurs revealed no significant change in leptin levels (P>0.05). Multivariate Logistic regression analysis showed that neither abdominal obesity nor leptin had significant impact on migraine clinical features. Total body obesity had a significant effect on the frequency (OR=4.248), duration (OR=3.167), and intensity (OR=5.225) of the headache.


CONCLUSIONS
Total body obesity affected headache frequency, intensity, and duration, while leptin levels did not.
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
Zhang
Z
Ligong
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
Qin
Q
Jinjin
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
Chen
C
Chunfu
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
Li
L
Congcong
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
Diao
D
Xiaojun
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000150:complications; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood* / Q000150:complications; D056128:Obesity, Abdominal / Q000097:blood; D016017:Odds Ratio; D011863:Radioimmunoassay; D055815:Young Adult
D020738:Leptin