Spinal cord involvement in Behçet's disease.
Spinal cord involvement in Behçet's disease is not well studied.



To evaluate the clinical, laboratory and magnetic resonance imaging characteristics of spinal cord involvement in Behçet's disease.



We retrospectively reviewed 10 spinal cord involvements in seven patients with Behçet's disease.



The median age of onset for spinal cord involvement was 32 (23-45 years). Two patients showed a secondary progressive course. Cerebrospinal fluid findings revealed mild to moderate pleocytosis and/or elevated protein levels. In eight spinal cord involvements, the lesion was longer than three vertebrae. Serum anti-aquaporin-4 antibody was negative in all four patients tested.



Longitudinally extensive transverse myelitis is a characteristic manifestation of spinal cord involvement in Behçet's disease.
Department of Neurology, Yonsei University College of Medicine, Republic of Korea.
Hyung Seok
HS
Lee
Department of Dermatology, Yonsei University College of Medicine, Republic of Korea.
Do Young
do Y
Kim
Department of Neurology, Yonsei University College of Medicine, Republic of Korea hayshin@yuhs.ac.
Ha Young
HY
Shin
Department of Neurology, Yonsei University College of Medicine, Republic of Korea.
Young-Chul
YC
Choi
Department of Neurology, Yonsei University College of Medicine, Republic of Korea.
Seung Min
SM
Kim
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000134:cerebrospinal fluid; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009188:Myelitis, Transverse / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D012042:Registries; D012189:Retrospective Studies; D013116:Spinal Cord / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers; D007166:Immunosuppressive Agents
Behçet’s disease; longitudinally extensive transverse myelitis; neuro-Behçet’s disease; neuromyelitis optica; serum anti-aquaporin-4 antibody; spinal cord