Association of Periodontitis With Urinary Albumin Excretion in Korean Adults With Diabetes: The 2012 Korea National Health and Nutrition Examination Survey.
Albuminuria and periodontitis are both commonly associated with systemic inflammation. However, the association between urinary albumin excretion (UAE) and periodontitis in patients with type 2 diabetes has not been fully investigated. This study aimed to investigate the association between UAE and periodontitis in Korean adults with type 2 diabetes.This study performed a cross-sectional analysis and used hierarchical multivariable logistic regression analysis models. Data from the 2012 Korean National Health and Nutrition Examination Survey were analyzed. A total of 547 patients, with type 2 diabetes without renal impairment, were included in this study. UAE was assessed using the urinary albumin to creatinine ratio (UACR). A community periodontal index greater than or equal to code 3 was used to define periodontitis.The risk of periodontitis tended to increase as UACR increased even after adjustment for potential confounders (P for trend in the odds ratios = 0.05 in model 1; 0.02 in model 2; and 0.01 in model 3). In a subgroup analysis, the prevalence of periodontitis was significantly higher in the patients with albuminuria (UACR >30 mg/g) than in those without albuminuria among patients younger than 65 years (P = 0.03), those with newly diagnosed diabetes (P = 0.04), or those without obesity (P = .04).UAE was positively associated with the risk of periodontitis in Korean adults with type 2 diabetes. In the patients who were younger, were newly diagnosed with diabetes, or had normal body mass index, individuals with albuminuria were more likely to have a higher prevalence of periodontitis. Early identification of periodontitis may be helpful in Korean diabetic adults with increased UAE.
From the Department of Biostatistics, College of Medicine, The Catholic University of Korea (KH, YGP), Department of Family Medicine, Korea University Hospital, College of Medicine, Korea University (GEN, DHK, KHC), Department of Periodontics, College of Medicine, The Catholic University of Korea (J-BP, YK); and Department of Family Medicine, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea (YKR).
Kyungdo
K
Han
Ga Eun
GE
Nam
Do Hoon
DH
Kim
Jun-Beom
JB
Park
Youngkyung
Y
Ko
Yong Kyun
YK
Roh
Kyung Hwan
KH
Cho
Yong Gyu
YG
Park
D000419:Albuminuria / Q000209:etiology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D009749:Nutrition Surveys; D010518:Periodontitis / Q000150:complications* / Q000652:urine*; D015995:Prevalence; D056910:Republic of Korea