[A Case of Concurrent Cancer of the Esophagus and Stomach with Severe Sepsis following Chemotherapy].
A 66-year-old man was diagnosed with synchronous early esophageal cancer and advanced gastric cancer. He received CDDP-based combination chemotherapy (docetaxcel, CDDP, and TS-1). During chemotherapy for gastric cancer, he suddenly developed septic shock, requiring intensive treatment with antibiotics, intravenous immunoglobulin, circulatory and respiratory care, and hemoperfusion with a polymyxin B column. He also had disseminated intravascular coagulation (DIC), complicated by sepsis. Recombinant human soluble thrombomodulin (rTM) was administered to treat DIC. The intensive treatments described above allowed the patient to recover from septic shock and DIC several days later. Early and adequate treatment could be used to rescue a compromised cancer-bearing patient from septic shock following chemotherapy.
Dept. of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Science, Kagoshima University.
Masahiko
M
Amatatsu
Hiroshi
H
Okumura
Yasuto
Y
Uchikado
Koichi
K
Megumi
Yoshiaki
Y
Kita
Yoshikazu
Y
Uenosono
Takaaki
T
Arigami
Shinichiro
S
Mori
Sumiya
S
Ishigami
Tetsuhiro
T
Owaki
Shoji
S
Natsugoe
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D018307:Neoplasms, Squamous Cell / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy / Q000209:etiology*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018180:Thrombomodulin / Q000627:therapeutic use
D011994:Recombinant Proteins; C546931:THBD protein, human; D018180:Thrombomodulin