Redox regulation of vascular remodeling.
Vascular remodeling is a dynamic process of structural and functional changes in response to biochemical and biomechanical signals in a complex in vivo milieu. While inherently adaptive, dysregulation leads to maladaptive remodeling. Reactive oxygen species participate in homeostatic cell signaling in tightly regulated- and compartmentalized cellular circuits. It is well established that perturbations in oxidation-reduction (redox) homeostasis can lead to a state of oxidative-, and more recently, reductive stress. We provide an overview of the redox signaling in the vasculature and review the role of oxidative- and reductive stress in maladaptive vascular remodeling. Particular emphasis has been placed on essential processes that determine phenotype modulation, migration and fate of the main cell types in the vessel wall. Recent advances in systems biology and the translational opportunities they may provide to specifically target the redox pathways driving pathological vascular remodeling are discussed.
Division of Cardiology, Center for Interventional Vascular Therapy, New York Presbyterian Hospital and Columbia University, New York, NY, USA. kk3102@cumc.columbia.edu.|Sydney Medical School Foundation, University of Sydney, Sydney, Australia. kk3102@cumc.columbia.edu.
Keyvan
K
Karimi Galougahi
Division of Cardiology, Stanford University, Stanford, CA, USA.
Euan A
EA
Ashley
Division of Cardiology, Center for Interventional Vascular Therapy, New York Presbyterian Hospital and Columbia University, New York, NY, USA.|Cardiovascular Research Foundation, New York, NY, USA.
Ziad A
ZA
Ali
D000818:Animals; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D006706:Homeostasis; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D066253:Vascular Remodeling
D017382:Reactive Oxygen Species; D052250:Nitric Oxide Synthase Type III
Reactive oxygen species; Redox stress; Signal transduction; Vascular remodeling