Genes, Genetics, and Environment in Type 2 Diabetes: Implication in Personalized Medicine.
Type 2 diabetes (T2D) is a multifactorial anomaly involving 57 genes located on 16 different chromosomes and 136 single nucleotide polymorphisms (SNPs). Ten genes are located on chromosome 1, followed by seven genes on chromosome 11 and six genes on chromosomes 3. Remaining chromosomes harbor two to five genes. Significantly, chromosomes 13, 14, 16, 18, 21, 22, X, and Y do not have any associated diabetogenic gene. Genetic components have their own pathways encompassing insulin secretion, resistance, signaling, and β-cell dysfunction. Environmental factors include epigenetic changes, nutrition, intrauterine surroundings, and obesity. In addition, ethnicity plays a role in conferring susceptibility to T2D. This scenario poses a challenge toward the development of biomarker for quick disease diagnosis or for generating a consensus to delineate different categories of T2D patients. We believe, before prescribing a generic drug, detailed genotypic information with the background of ethnicity and environmental factors may be taken into consideration. This nonconventional approach is envisaged to be more robust in the context of personalized medicine and perhaps would cause lot less burden on the patient ensuring better management of T2D.
Molecular Genetics Laboratory, National Institute of Immunology , New Delhi, India .
Nabodita
N
Kaul
Molecular Genetics Laboratory, National Institute of Immunology , New Delhi, India .
Sher
S
Ali
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism / Q000628:therapy*; D004777:Environment; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D053858:Metabolic Networks and Pathways / Q000235:genetics; D057285:Precision Medicine / Q000379:methods* / Q000639:trends
D007328:Insulin