A microsimulation model for the development and progression of chronic obstructive pulmonary disease.
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that is thought to affect over one million people in Great Britain. The main factor contributing to the development of COPD is tobacco smoke. This paper presents a microsimulation model for the development of COPD, incorporating population dynamics and trends in smoking. The model simulates a population longitudinally throughout their lifetimes, providing projections of future COPD prevalence and evaluation of the effects of changes in risk factor prevalence such as smoking. Sensitivity analysis provides information on the most influential model parameters. The model-predicted prevalence of COPD in 2040 was 17% in males over the age of 35 years (13% amongst non-smokers and 22% amongst smokers), and a modest decline over the next 25 years due to recent trends in smoking rates. The simulation model provides us with valuable information on current and future trends in COPD in Great Britain. It was developed primarily to enable easy extension to evaluate the effects of occupational and environmental exposures on lung function and the prevalence of COPD and to allow evaluation of interventions, such as introducing health surveillance or policy changes. As longitudinal studies for investigating COPD are difficult due to the lengthy follow-up time required and the potentially large number of drop-outs, we anticipate that the model will provide a valuable tool for health impact assessment. An extended model for occupational exposures is under development and will be presented in a subsequent paper.
Health and Safety Laboratory, Buxton SK17 9JN, United Kingdom. Electronic address: emma.tan@hsl.gsi.gov.uk.
Emma
E
Tan
TNO, P.O. Box 360, 3700 AJ Zeist, Netherlands.
Ruud
R
Boessen
Health and Safety Laboratory, Buxton SK17 9JN, United Kingdom; University of Sheffield, Sheffield, United Kingdom.
David
D
Fishwick
TNO, P.O. Box 360, 3700 AJ Zeist, Netherlands.
Rinke
R
Klein Entink
Shell, Netherlands.
Tim
T
Meijster
TNO, P.O. Box 360, 3700 AJ Zeist, Netherlands.
Anjoeka
A
Pronk
TNO, P.O. Box 360, 3700 AJ Zeist, Netherlands.
Birgit
B
van Duuren-Stuurman
Health and Safety Laboratory, Buxton SK17 9JN, United Kingdom.
Nick
N
Warren
D000328:Adult; D017677:Age Distribution; D000368:Aged; D018450:Disease Progression; D004781:Environmental Exposure / Q000009:adverse effects / Q000706:statistics & numerical data; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D062489:Health Impact Assessment; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D016273:Occupational Exposure / Q000009:adverse effects / Q000706:statistics & numerical data; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology; D014797:Vital Capacity / Q000502:physiology
Chronic obstructive pulmonary disease; Disease model; Microsimulation; Smoking