Preparation, Evaluation and Optimization of Multiparticulate System of Mebendazole for Colon Targeted Drug Delivery by Using Natural Polysaccharides.
OBJECTIVE
A Multiparticulate system of Mebendazole was developed for colon targeted drug delivery by using natural polysaccharides like Chitosan and Sodium-alginate beads.


METHODS
Chitosan microspheres were formulated by using Emulsion crosslinking method using Glutaraldehyde as crosslinking agent. Sodium-alginate beads were formulated by using Calcium chloride as gelling agent. Optimization for Chitosan microspheres was carried out by using 2(3) full factorial design. 3(2) full factorial design was used for the optimization of Sodium-alginate beads. The formulated batches were evaluated for percentage yield, particle size measurement, flow properties, percent entrapment efficiency, Swelling studies. The formulations were subjected to Stability studies and In-vitro release study (with and without rat caecal content). Release kinetics data was subjected to different dissolution models.


RESULTS
The formulated batches showed acceptable particle size range as well as excellent flow properties. Entrapment efficiency for optimized batches of Chitosan microspheres and sodium alginate beads was found to be 74.18% and 88.48% respectively. In-vitro release of drug for the optimized batches was found to be increased in presence of rat caecal content. The best-fit models were koresmeyer-peppas for Chitosan microspheres and zero order for sodium-alginate beads.


CONCLUSIONS
Chitosan and Sodium-alginate was used successfully for the formulation of Colon targeted Multiparticulate system.
Faculty of Pharmaceutics, PES's Modern College Of Pharmacy (For Ladies), Moshi, Savitribai Phule Pune University, Maharashtra, India.
Kuldeep
K
Hemraj Ramteke
Faculty of Pharmaceutics, PES's Modern College Of Pharmacy (For Ladies), Moshi, Savitribai Phule Pune University, Maharashtra, India.
Varsha
V
Balaji Jadhav
Faculty of Pharmaceutics, PES's Modern College Of Pharmacy (For Ladies), Moshi, Savitribai Phule Pune University, Maharashtra, India.
Nilesh Shrikant
NS
Kulkarni
Faculty of Pharmaceutics, PES's Modern College Of Pharmacy (For Ladies), Moshi, Savitribai Phule Pune University, Maharashtra, India.
Amol Rameshrao
AR
Kharat
Faculty of Pharmaceutics, PES's Modern College Of Pharmacy (For Ladies), Moshi, Savitribai Phule Pune University, Maharashtra, India.
Sonali Bhima
SB
Diwate
Colon targeted drug delivery; Mebendazole; Multiparticulate system; Natural Polysaccharides