[Prevalence, indication and compliance with the recommendations of prescription of low molecular weight heparin in oncology].
BACKGROUND
Venous thromboembolism is a common complication in cancer and is the second cause of death below infection. Low molecular weight heparin is the gold standard in venous thromboembolism during cancer. This work aimed to evaluate the prevalence of prescription of low molecular weight heparin used at curative dose and the compliance of our practices with the recommendations.


METHODS
A retrospective study was led over a 3-month period, on adult patients suffering from venous thromboembolism who had received low molecular weight heparin at curative dose.


RESULTS
A 4% prevalence of prescription of low molecular weight heparin at curative doses has been reported. The results showed an incidental discovery of venous thromboembolism on routine restaging scans in 64% cases. The most found indication was the treatment of deep vein thrombosis (51% cases). According to the dosage, overall compliance of prescription is estimated at 55%.


CONCLUSIONS
The incidental discovery rate (64%) is consistent with the literature that confirms the high incidence of asymptomatic thrombosis. The rate of non-compliant prescriptions could result from a lack of re-evaluation and adjustment of dosages. These results confirm the need to educate practitioners in diagnosing and managing venous thromboembolism.
Centre Oscar-Lambret, département d'anesthésie, réanimation et algologie, 3, rue Combemale, 59020 Lille cedex, France.
Jérôme
J
Danklou
Centre Oscar-Lambret, service de pharmacie, 3, rue Frédéric-Combemale, BP 307, 59020 Lille cedex, France.
Geoffrey
G
Strobbe
Centre Oscar-Lambret, service de pharmacie, 3, rue Frédéric-Combemale, BP 307, 59020 Lille cedex, France.
Stéphanie
S
Delbey
Centre Oscar-Lambret, département d'anesthésie, réanimation et algologie, 3, rue Combemale, 59020 Lille cedex, France.
Danièle
D
Lefebvre-Kuntz
Centre Oscar-Lambret, service de pharmacie, 3, rue Frédéric-Combemale, BP 307, 59020 Lille cedex, France. Electronic address: g-marliot@o-lambret.fr.
Guillaume
G
Marliot
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D058070:Asymptomatic Diseases / Q000453:epidemiology / Q000628:therapy; D011307:Drug Prescriptions / Q000592:standards* / Q000706:statistics & numerical data; D005260:Female; D019983:Guideline Adherence; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D012189:Retrospective Studies; D054556:Venous Thromboembolism / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D020246:Venous Thrombosis / Q000188:drug therapy
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight
Cancer; Héparine de bas poids moléculaire; Low molecular weight heparin; Thrombose; Thrombosis