Gut-Busters: IL-17 Ain't Afraid of No IL-23.
Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. In this issue, Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, helping explain this dichotomy (Lee et al., 2015; Maxwell et al., 2015).
Kennedy Institute of Rheumatology, University of Oxford, Oxford, OX3 7FY, UK.
Natasha
N
Whibley
Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh PA 15261, USA. Electronic address: sarah.gaffen@pitt.edu.
Sarah L
SL
Gaffen
D000818:Animals; D003092:Colitis / Q000276:immunology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000502:physiology*; D053759:Interleukin-23 / Q000502:physiology*; D007413:Intestinal Mucosa / Q000503:physiopathology*; D053722:Receptors, Interleukin-17 / Q000502:physiology*
D020381:Interleukin-17; D053759:Interleukin-23; D053722:Receptors, Interleukin-17