[Research progress of TRPV4 and cerebral ischemic reperfusion injury].
Transient receptor potential vanilloid 4 (TRPV4) channel is a member of transient receptor potential superfamily. TRPV4 is selectively permeable to calcium. Activation of the TRPV4 channel induces an increase in intracellular calcium concentration and plays an important role under physiological and pathological conditions. Especially, there is evidence showing that TRPV4 is involved in cerebral ischemic reperfusion injury. The present paper reviewed some research progress about the role of TRPV4 in cerebral ischemic reperfusion injury.
Class 4 Grade 2012, Seven-year Program of Clinical Medicine, Nanjing Medical University, Nanjing 210029, China.
Hao
H
Ding
Class 4 Grade 2012, Seven-year Program of Clinical Medicine, Nanjing Medical University, Nanjing 210029, China.
Ye-Xin
YX
Lin
Class 4 Grade 2012, Seven-year Program of Clinical Medicine, Nanjing Medical University, Nanjing 210029, China.
Qi-Wen
QW
Shen
Class 4 Grade 2012, Seven-year Program of Clinical Medicine, Nanjing Medical University, Nanjing 210029, China.
Zhi
Z
Pan
Class 4 Grade 2012, Seven-year Program of Clinical Medicine, Nanjing Medical University, Nanjing 210029, China.
Zhen-Chao
ZC
Wang
Department of Physiology, Nanjing Medical University, Nanjing 210029, China. chenl@njmu.edu.cn.
Lei
L
Chen
D002545:Brain Ischemia; D002118:Calcium / Q000502:physiology*; D006801:Humans; D015427:Reperfusion Injury; D050916:TRPV Cation Channels / Q000502:physiology*
D050916:TRPV Cation Channels; C416986:TRPV4 protein, human; D002118:Calcium