Failure to thrive and life-threatening complications due to inherited selective cobalamin malabsorption effectively managed in a juvenile Australian shepherd dog.
A juvenile Australian shepherd dog exhibited failure to grow, inappetence, weakness, nonregenerative anemia, neutropenia, and cobalamin deficiency. DNA testing confirmed homozygosity of an amnionless mutation (AMN c.3G > A). Clinical signs resolved with supportive care and parenteral cobalamin supplementation. Inherited selective intestinal cobalamin malabsorption requiring lifelong parenteral supplementation should be considered in Australian shepherds, giant schnauzers, border collies, and beagles that fail to thrive.
Department of Small Animal Clinical Sciences (Gold, Fyfe), Pathobiology and Diagnostic Investigation (Scott), Laboratory of Comparative Medical Genetics (Fyfe), College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA.
Ashley J
AJ
Gold
Department of Small Animal Clinical Sciences (Gold, Fyfe), Pathobiology and Diagnostic Investigation (Scott), Laboratory of Comparative Medical Genetics (Fyfe), College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA.
Michael A
MA
Scott
Department of Small Animal Clinical Sciences (Gold, Fyfe), Pathobiology and Diagnostic Investigation (Scott), Laboratory of Comparative Medical Genetics (Fyfe), College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA.
John C
JC
Fyfe
D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D004285:Dogs; D020022:Genetic Predisposition to Disease; D008286:Malabsorption Syndromes / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000627:therapeutic use*; D014806:Vitamin B 12 Deficiency / Q000473:pathology / Q000662:veterinary*
D014805:Vitamin B 12