Arrhythmias in Adult Congenital Patients With Bodily Isomerism.
There are an increasing number of adults with congenital heart disease, some of whom have bodily isomerism. Bodily isomerism or heterotaxy is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of arrhythmias in adults with bodily isomerism. We utilized the 2012 iteration of the Nationwide Inpatient Sample to identify adult inpatient admissions associated with arrhythmias in patients with isomerism. Data regarding demographics, comorbidities, and various procedures were collected and compared between those with and without isomerism. A total of 6,907,109 admissions were analyzed with a total of 861 being associated isomerism. The frequency of arrhythmias was greater in those with isomerism (20.8 vs. 15.4 %). Those with isomerism were also more five times more likely to undergo invasive electrophysiology studies. Length and cost of hospitalization for patients with arrhythmias also tended to be greater in those with isomerism. Mortality did not differ between the two groups. Arrhythmias are more prevalent in those with isomerism, with a majority of arrhythmias in isomerism being atrial. Those with isomerism and arrhythmias also tended to have greater length and cost of hospitalization.
Medical College of Wisconsin, Milwaukee, WI, USA. rloomba@mcw.edu.
Rohit S
RS
Loomba
Creighton University Medical Center, Omaha, NE, USA.
Saurabh
S
Aggarwal
Medical College of Wisconsin, Milwaukee, WI, USA.
Navdeep
N
Gupta
Medical College of Wisconsin, Milwaukee, WI, USA.
Matthew
M
Buelow
Creighton University Medical Center, Omaha, NE, USA.
Venkata
V
Alla
Chicago Medical School, North Chicago, IL, USA.
Rohit R
RR
Arora
Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Robert H
RH
Anderson
D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000145:classification* / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology*; D059446:Heterotaxy Syndrome / Q000150:complications*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D014481:United States; D055815:Young Adult
Arrhythmias; Atrioventricular block; Conduction; Heterotaxy; Isomerism; Supraventricular tachycardia