Toll-like receptor-2 and -4 are associated with hyperlipidemia.
Recent studies have suggested that toll-like receptors (TLRs) contribute to insulin resistance, and that fatty acids have a role in TLR activation. Other studies have found that TLR2 and TLR4 upregulation is consistent with an increase in serum lipid. Therefore, it was hypothesized that TLRs are associated with hyperlipidemia. The aim of the present study was to investigate whether TLR2 or TLR4 was associated with hyperlipidemia and to provide novel targets for hyperlipidemia therapy. Volunteers were selected at the Medical Examination Center of Hebei General Hospital (Shijiazhuang, China), including 43 patients with high triglyceride (TG) levels, 84 with high total cholesterol (TC) levels and 55 with high TG and high TC levels. In addition, 68 healthy volunteers were selected as a control group. For the animal study, the TLR gene and protein levels were assessed in the skeletal muscle of rats fed a high‑fat diet. As expected, TLR2 and TLR4 gene expression were upregulated when TC increased, TG increased, or TC and TG increased. In rats fed a high‑fat diet, the levels of gene and protein expression in the skeletal muscle of the two TLRs were all increased compared with the control group, this was consistent with an increase in TC and TG. In addition, in drug treatment groups the mRNA and protein expression levels of TLR in the skeletal muscle of rats fed a high fat diet were decreased, as were the TC and TG levels. In conclusion, these findings suggest that TLR2 and TLR4 are associated with hyperlipidemia.
Postgraduate Department, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
Ya-Jun
YJ
Zhu
Department of Clinical Medical Research Center, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Chao
C
Wang
Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
Guangyao
G
Song
Postgraduate Department, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
Sha-Sha
SS
Zang
Postgraduate Department, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
Yi-Xuan
YX
Liu
Postgraduate Department, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
Ling
L
Li
D000818:Animals; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D005786:Gene Expression Regulation; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014280:Triglycerides / Q000097:blood
C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D014280:Triglycerides; D002784:Cholesterol