Adult Onset of BRAF(V600E)-Mutated Langerhans Cell Histiocytosis with Cutaneous Involvement Successfully Diagnosed by Immunohistochemical Staining.
Langerhans cell histiocytosis (LCH) is characterized by the clonal proliferation of Langerhans cells; it is categorized as a single-system disease with single or multifocal lesions, and as a multi-system disease with or without the risk of organ involvement. Although the skin is not categorized as a risk organ, the precise diagnosis of skin lesions is necessary to determine the protocol for the treatment of LCH. In this report, we describe a 28-year-old Japanese man with adult onset of BRAF(V600E)-mutated LCH with cutaneous involvement successfully diagnosed by immunohistochemical staining. Our report suggests that immunohistochemical staining for the BRAF(V600E) gene could be a diagnostic tool to determine the clinical type of LCH.
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hisayuki
H
Tono
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Taku
T
Fujimura
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Aya
A
Kakizaki
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Sadanori
S
Furudate
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masaya
M
Ishibashi
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Setsuya
S
Aiba
Adult onset of Langerhans cell histiocytosis; BRAFV600E; Chemotherapy; Clinical type