Proteomic approach to nanotoxicity.
In recent years a large number of engineered nanomaterials (NMs) have been developed with promising technical benefits for consumers and medical appliances. In addition to already known potentially advantageous biological properties (antibiotic, antifungal and antiviral activity) of NMs, many new medical applications of NMs are foreseen, such as drug carriers, contrast agents, radiopharmaceuticals and many others. However, there is increasing concern about potential environmental and health effects due to NMs exposure. An increasing body of evidence suggests that NMs may trigger undesirable hazardous interactions with biological systems with potential to generate harmful effects. In this review we summarized a current state of knowledge on the proteomics approaches to nanotoxicity, including protein corona formation, in vitro and in vivo effects of exposure to NMs on proteome of different classes of organisms, from bacteria and plants to mammals. The effects of NMs on the proteome of environmentally relevant organisms are also described.


CONCLUSIONS
Despite the benefit that development of nanotechnology may bring to the society, there are still major gaps of knowledge on the influence of nanomaterials on human health and the environment. Thus, it seems necessary to conduct further interdisciplinary research to fill the knowledge gaps in NM toxicity, using more holistic approaches than offered by conventional biological techniques. “OMICS” techniques will certainly help researchers in this field. In this paper we summarized the current stage of knowledge of the effects of nanoparticles on the proteome of different organisms, including those commonly used as an environmentally relevant indicator organisms.
Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland.
Magdalena
M
Matysiak
Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland; Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Rzeszow, Poland.
Lucyna
L
Kapka-Skrzypczak
Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland.
Kamil
K
Brzóska
Environmental Research and Innovation Department, Luxembourg Institute of Science and Technology (LIST), Esch-sur-Alzette, Luxembourg.
Arno C
AC
Gutleb
Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland; Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Rzeszow, Poland; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland. Electronic address: m.kruszewski@ichtj.waw.pl.
Marcin
M
Kruszewski
D000818:Animals; D006801:Humans; D053758:Nanoparticles / Q000633:toxicity*; D040901:Proteomics / Q000379:methods*; D014116:Toxicology / Q000379:methods*
Nanomaterials; Nanoparticles; Nanotoxicology; Protein expression