Rheological Analysis of Polymer Interactions and Ageing of Poly(Methylvinylether-Co-Maleic Anhydride)/Poly(Vinyl Alcohol) Binary Networks and Their Effects on Mucoadhesion.
Polymer blends of poly(vinylalcohol, PVA) and poly(methylvinylether-co-maleic anhydride, PMVE/MA) were formulated and their viscoelastic and mucoadhesive properties characterised. The viscoelastic and mucoadhesive properties were dependent on polymer concentration, molecular weight of PVA and PVA:PMVE/MA ratio. Alteration of these properties allowed platforms to be designed to offer defined rheological and mucoadhesive properties, properties that could not be achieved using monopolymeric platforms. A strong correlation was noted between the modulus of the polymeric blends and mucoadhesion. After storage, the polymeric blends underwent rheological structuring (ageing) with an attendant enhancement of mucoadhesion. In certain blends containing the highest molecular weight of PVA (146-186 kDa), storage ultimately resulted in an increase and then a significant decrease in the rheological and mucoadhesive properties, the latter phenomenon being accredited to polymer recrystallisation. Ageing of the rheological and mucoadhesive properties was modelled using an exponential growth model, allowing predictions of the storage period associated with the maxima in viscoelastic and mucoadhesive properties. These observations highlight the possible implications whenever interactive polymeric blends are employed in drug delivery. Caution is therefore urged whenever a formulation strategy based on interactive polymer blends is employed to ensure that ageing is fully understood and mathematically characterised.
School of Pharmacy, Queen's University of Belfast, Medical Biology Centre, Belfast BT9 7BL, Northern Ireland.
Gavin P
GP
Andrews
School of Pharmacy, Queen's University of Belfast, Medical Biology Centre, Belfast BT9 7BL, Northern Ireland.
Thomas P
TP
Laverty
School of Pharmacy, Queen's University of Belfast, Medical Biology Centre, Belfast BT9 7BL, Northern Ireland. Electronic address: d.jones@qub.ac.uk.
David S
DS
Jones
D000268:Adhesiveness; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003460:Crystallization; D016503:Drug Delivery Systems / Q000379:methods; D008298:Maleates / Q000737:chemistry*; D011095:Polyethylenes / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012212:Rheology
D008298:Maleates; D011095:Polyethylenes; D011108:Polymers; D011142:Polyvinyl Alcohol; C043105:poly(methyl vinyl ether-co-maleic anhydride)
biomaterials; formulation; gels; materials science; mucoadhesive; polymers; rheology