Implications of Renal Denervation Therapy in Patients with Sleep Apnea.
Obstructive sleep apnea (OSA) syndrome is a prevalent condition characterized by repeated episodes of obstruction of the upper airway, leading to intermittent hypoxemia and important endothelial and anatomical dysfunctions that cause cardiovascular and cerebrovascular disease. The finding of the relationship between OSA and hypertension, especially resistant hypertension (RHT), has increased the interest in therapeutic strategies that affect renal sympathetic activity in these patients. The observational studies published until now demonstrated that renal denervation therapy can reduce the severity of OSA syndrome. Renal sympathetic denervation (RDN) could be a future therapeutic possibility for conditions other than RHT, such as atrial fibrillation, heart failure, obesity, and OSA syndrome, where renal sympathetic system plays an important physiological role. The aim of this review was to elucidate the implications of renal sympathetic activity in OSA syndrome.
Cardiovascular Risk Unit, Department of Internal Medicine, University Hospital Complex City of Granada, Avenida Fuerzas Armadas 2, 18014 Granada, Spain.
Fernando
F
Jaén-Águila
Cardiovascular Risk Unit, Department of Internal Medicine, University Hospital Complex City of Granada, Avenida Fuerzas Armadas 2, 18014 Granada, Spain.
José Antonio
JA
Vargas-Hitos
Cardiovascular Risk Unit, Department of Internal Medicine, University Hospital Complex City of Granada, Avenida Fuerzas Armadas 2, 18014 Granada, Spain.
Juan Diego
JD
Mediavilla-García