Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy.
Designing a multifunctional nanomedicine for integration of precise diagnosis and effective treatment of tumors is desirable but remains a great challenge. Here, we report a multifunctional nanomedicine based on WS2 quantum dots (QDs), which was prepared by a facile and "green" method through physical grinding and ultrasonication. The as-obtained WS2 QDs with small size (3 nm) possess not only significant X-ray computed tomography (CT)/photoaccoustic (PA) imaging signal enhancement but also remarkable photothermal therapy (PTT)/radiotherapy (RT) synergistic effect for tumor treatment. With CT/PA imaging and the synergistic effect between PTT and RT, the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of WS2 QDs. Moreover, hematoxylin and eosin staining, blood hematology, and biochemistry analysis revealed no noticeable toxicity of WS2 QDs in vitro and in vivo, which confirmed that WS2 QDs possess good biocompatibility. This multifunctional nanoparticle could play an important role in facilitating simultaneously multimodal imaging and synergistic therapy between PTT and RT to achieve better therapeutic efficacy.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience Technology of China, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Yuan
Y
Yong
Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Jiangsu Provincial Key Lab of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences, Soochow University , Suzhou 215123, People's Republic of China.
Xiaju
X
Cheng
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience Technology of China, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Tao
T
Bao
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience Technology of China, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Mian
M
Zu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience Technology of China, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Liang
L
Yan
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience Technology of China, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Wenyan
W
Yin
Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Jiangsu Provincial Key Lab of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences, Soochow University , Suzhou 215123, People's Republic of China.
Cuicui
C
Ge
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience Technology of China, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Dongliang
D
Wang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience Technology of China, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Zhanjun
Z
Gu
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience Technology of China, Chinese Academy of Sciences , Beijing 100049, People's Republic of China.|Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Jiangsu Provincial Key Lab of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences, Soochow University , Suzhou 215123, People's Republic of China.
Yuliang
Y
Zhao
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D061088:Photoacoustic Techniques; D045663:Quantum Dots / Q000737:chemistry* / Q000633:toxicity; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D013440:Sulfides / Q000737:chemistry*; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014414:Tungsten / Q000737:chemistry*
D013440:Sulfides; D014414:Tungsten
WS2 quantum dots; X-ray computed tomography; photoaccoustic imaging; photothermal therapy; radiotherapy therapy; synergistic therapy