Sonoclot(®)-based method to detect iron enhanced coagulation.
Thrombelastographic methods have been recently introduced to detect iron mediated hypercoagulability in settings such as sickle cell disease, hemodialysis, mechanical circulatory support, and neuroinflammation. However, these inflammatory situations may have heme oxygenase-derived, coexistent carbon monoxide present, which also enhances coagulation as assessed by the same thrombelastographic variables that are affected by iron. This brief report presents a novel, Sonoclot-based method to detect iron enhanced coagulation that is independent of carbon monoxide influence. Future investigation will be required to assess the sensitivity of this new method to detect iron mediated hypercoagulability in clinical settings compared to results obtained with thrombelastographic techniques.
Department of Anesthesiology, The University of Arizona College of Medicine, 1501 North Campbell Avenue, P.O. Box 245114, Tucson, AZ, 85724-5114, USA. vgnielsen333@gmail.com.
Vance G
VG
Nielsen
Sienco, Inc., Boulder, CO, USA.
Jon
J
Henderson
D001777:Blood Coagulation; D002248:Carbon Monoxide / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood / Q000502:physiology*; D012680:Sensitivity and Specificity; D013916:Thrombelastography / Q000379:methods*; D019851:Thrombophilia / Q000097:blood* / Q000175:diagnosis
D002248:Carbon Monoxide; D007501:Iron
Carbon monoxide; Hypercoagulability; Iron; Viscoelasticity; Viscosity