Breast MR biopsy: Pathological and radiological correlation.
OBJECTIVE
To identify pathological features for sample analysis of magnetic resonance imaging-guided vaccum-assisted breast biopsy (MRIgVaBB) to optimize radio pathological correlation and identify discordant benign result.


METHODS
Databases of two centres were queried to identify MRIgVaBB performed between January 2009 and February 2013. A cohort of 197 women (mean age: 54.5 years (24-77)) with 208 lesions was identified. We retrospectively analyzed all prebiopsy MRI examinations according to the new BI-RADS lexicon, and all biopsy samples to describe the lesion of interest, its interface with the surrounding breast tissue and other associated features.


RESULTS
The malignancy rate was 26.0 % (54/208) with an underestimation rate of 15.67 % (5/32). A visible interface at pathology between a biopsied lesion and the surrounding breast tissue was more frequently identified in mass enhancement compared to NME or focus (p = 0.0003). Regional NME was correlated with a high degree of fibrosis (p = 0.001) and the presence of PASH (p = 0.0007). Linear or segmental NME was correlated with the presence of periductal mastitis (p = 0.0003).


CONCLUSIONS
The description of a visible interface between the target lesion and the surrounding tissue is crucial to confirm the correct targeting of an MR mass or a NME.


CONCLUSIONS
• Pathological interface correlated with magnetic resonance mass and focal non-mass enhancement (NME). • Linear or segmental NME correlated with mastitis or ductal carcinoma in situ. • Fibrosis and pseudoangiomatous stromal hyperplasia (PASH) are correlated with regional NME.
Department of Radiology, AP-HP, Hôpital Tenon, 75020, Paris, France. chloedratwa@gmail.com.
Chloé
C
Dratwa
Department of Radiology, Institut Paoli-Calmettes, 13009, Marseille, France.
Aurélie
A
Jalaguier-Coudray
Biopathology Department, Institut Paoli-Calmettes, 13009, Marseille, France.
Jeanne
J
Thomassin-Piana
Department of Pathology, AP-HP, Hôpital Tenon, 75020, Paris, France.
Julie
J
Gonin
Department of Radiology, AP-HP, Hôpital Tenon, 75020, Paris, France.
Jocelyne
J
Chopier
Department of Pathology, AP-HP, Hôpital Tenon, 75020, Paris, France.
Martine
M
Antoine
Department of Radiology, Hôtel-Dieu de Montréal, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada, H2W 1T8.
Isabelle
I
Trop
Department of Gynaecology and Obstetrics, AP-HP, Hôpital Tenon, 75020, Paris, France.|UPMC Univ Paris 06, IUC, Sorbonne Universités, 75005, Paris, France.
Emile
E
Darai
Department of Radiology, AP-HP, Hôpital Tenon, 75020, Paris, France.|UPMC Univ Paris 06, IUC, Sorbonne Universités, 75005, Paris, France.|INSERM, UMR970, Equipe 2, Imagerie de l'angiogenèse, 75005, Paris, France.
Isabelle
I
Thomassin-Naggara
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D001940:Breast / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000175:diagnosis*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis*; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
Biopsy; Breast; Magnetic Resonance Imaging; Neoplasms; Pathology