Tissue patterning and cellular mechanics.
In development, cells organize into biological tissues through cell growth, migration, and differentiation. Globally, this process is dictated by a genetically encoded program in which secreted morphogens and cell-cell interactions prompt the adoption of unique cell fates. Yet, at its lowest level, development is achieved through the modification of cell-cell adhesion and actomyosin-based contractility, which set the level of tension within cells and dictate how they pack together into tissues. The regulation of tension within individual cells and across large groups of cells is a major driving force of tissue organization and the basis of all cell shape change and cell movement in development.
Howard Hughes Medical Institute, Robin Neustein Chemers Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065.
Evan
E
Heller
Howard Hughes Medical Institute, Robin Neustein Chemers Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065 fuchslb@rockefeller.edu.
Elaine
E
Fuchs
D019521:Body Patterning / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D048430:Cell Shape / Q000502:physiology*; D006801:Humans; D055595:Mechanical Phenomena; D040542:Mechanotransduction, Cellular