Expression profiling of wild type and β-catenin gene disrupted human BxPC-3 pancreatic adenocarcinoma cells.
To study the role of WNT/β-catenin signaling in pancreatic adenocarcinoma, human BxPC-3 cell lines deficient of the central canonical WNT signaling protein β-catenin were established by using zinc-finger nuclease mediated targeted genomic disruption of the β-catenin gene (CTNNB1). Comparison of the global transcription levels in wild type cells with two β-catenin gene disrupted clones identified 85 transcripts that were the most differentially regulated. Gene ontology (GO) term enrichment analysis of these transcripts identified "cell adhesion" as the most significantly enriched GO term. Here we describe the data from the transcription profiling analysis published in the article "Implications of Targeted Genomic Disruption of β-Catenin in BxPC-3 Pancreatic Adenocarcinoma Cells" [1]. Data have been deposited to the Gene Expression Omnibus (GEO) database repository with the dataset identifier GSE63072.
Oslo University Hospital-Rikshospitalet, Dep. of Microbiology, Section for Cell Signaling, Gaustadalleen 34, 0373 Oslo, Norway.
Petter Angell
PA
Olsen
Oslo University Hospital-Rikshospitalet, Dep. of Microbiology, Section for Cell Signaling, Gaustadalleen 34, 0373 Oslo, Norway.
Kaja
K
Lund
Oslo University Hospital-Rikshospitalet, Dep. of Microbiology, Section for Cell Signaling, Gaustadalleen 34, 0373 Oslo, Norway.
Stefan
S
Krauss
Beta-catenin; Pancreatic cancer; WNT