Association of circulating adipokines with metabolic dyslipidemia in obese versus non-obese individuals.
OBJECTIVE
Previous studies have shown that circulating adipokines may play an important role in the pathogenesis of some obesity related chronic disease such as dyslipidemia and type2 diabetes mellitus. The aim of the present study was to investigate the association between vaspin, omentin-1 and retinol binding protein-4 levels with metabolic dyslipidemia (MD) criteria in obese and non-obese individuals.


METHODS
The study was conducted on 170 obese and 81 non-obese individuals. After collecting the blood samples, serum levels metabolic parameters as well as three circulating adipokines and body composition were measured.


RESULTS
No significant difference was noted regarding the mean serum levels of omentin-1 and vaspin between the obese and non-obese groups, while, serum level of RBP4 was significantly higher in the non-obese group. We found the 0.22 increased risk of MD in obese individuals with higher RBP4 concentration. After the adjustment for confounding factors, this association was still significant. No significant association was noted between MD and its components relative risks with omentin-1 and vaspin levels.


CONCLUSIONS
Our study demonstrated that circulating RBP4 was significantly higher in the obese individuals which may increase the risk of MD in them. Further researches are needed to address this association.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Mehran
M
Rahimlou
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: mirzaei_kh@tums.ac.ir.
Khadijeh
K
Mirzaei
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Seyed Ali
SA
Keshavarz
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA.
Arash
A
Hossein-Nezhad
D054392:Adipokines / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications* / Q000378:metabolism; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D056865:Ideal Body Weight; D037102:Lectins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications* / Q000378:metabolism; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism; D015843:Serpins / Q000097:blood; D055815:Young Adult
D054392:Adipokines; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; C507339:SERPINA12 protein, human; D015843:Serpins
Metabolic dyslipidemia; Obesity; Omentin-1; RBP4; Vaspin