Fosfomycin Resistance in Escherichia coli, Pennsylvania, USA.
Fosfomycin resistance in Escherichia coli is rare in the United States. An extended-spectrum β-lactamase-producing E. coli clinical strain identified in Pennsylvania, USA, showed high-level fosfomycin resistance caused by the fosA3 gene. The IncFII plasmid carrying this gene had a structure similar to those found in China, where fosfomycin resistance is commonly described.
Hind
H
Alrowais
Christi L
CL
McElheny
Caressa N
CN
Spychala
Sangeeta
S
Sastry
Qinglan
Q
Guo
Adeel A
AA
Butt
Yohei
Y
Doi
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics / Q000276:immunology*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D005578:Fosfomycin / Q000276:immunology* / Q000494:pharmacology*; D006801:Humans; D010414:Pennsylvania / Q000453:epidemiology; D017422:Sequence Analysis, DNA / Q000706:statistics & numerical data
D000900:Anti-Bacterial Agents; D005578:Fosfomycin
16S rRNA methyltransferase; ESBL; Escherichia coli; Pennsylvania; United States; antimicrobial resistance; bacteria; extended-spectrum β-lactamase; fosA3 gene; fosfomycin resistance; glutathione S-transferase; plasmids