Clinicopathological Variation of Lauren Classification in Gastric Cancer.
The investigation of prognostic factor for gastric cancer is still desirable because of dismal prognosis in gastric cancer. Lauren's classification is currently a useful histological classification. There are few large series evaluating the prognostic significance of Lauren's classification in gastric cancer. From January 1987 to December 2013, a total of 3071 patients received gastrectomy for gastric cancer. According Lauren's classification, 1423(46.3%) patients were intestinal type, 1000 patients (32.6%) were diffuse type, and 648 patients (21.1%) were mixed type. The clinicopathological characteristics and prognosis in Lauren's classification were analyzed in these patients. Our results showed that patients with intestinal type gastric cancer (57.7%) had a better 5-year overall survival than diffuse type (45.6%) and mixed type (43.4%, P < 0.001). The clinicopathological characteristics showed that gastric cancer patients with intestinal type were older (P < 0.001), male predominant (P < 0.001), smaller tumor size (P < 0.001), distal stomach predominant (P < 0.001), relative well differentiated (P < 0.001), less advanced Borrmann type (P < 0.001), less scirrhous type stromal reaction(P < 0.001), less infiltrating type of Ming's histology type(P < 0.001), less tumor invasion depth and less lymphovascular invasion (P < 0.001). Multivariate analysis with overall survival as an endpoint showed that age (P = 0.005), Borrmann classification (P < 0.001), pathological T category (P = 0.023), pathological N category (P < 0.001) and Lauren's classification (P = 0.003) were significant correlated in gastric cancer. Lauren's classification is an independent prognostic factor in gastric cancer patient undergoing gastrectomy. Lauren's classification can serve as a prognostic marker for gastric cancer patient receiving gastrectomy. The clinicopathological appearance and prognosis of mixed type gastric cancer is similar to diffuse type gastric cancer.
Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Yun-Chi
YC
Chen
Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Wen-Liang
WL
Fang
Department of Emergency Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.|School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
Ruei-Fang
RF
Wang
School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.
Chien-An
CA
Liu
Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Division of Hematology-Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Muh-Hwa
MH
Yang
School of Medicine, National Yang-Ming University, Taipei, Taiwan.|National Yang-Ming University Hospital, Yilan, Taiwan.
Shu-Shun
SS
Lo
Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Chew-Wen
CW
Wu
School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan.
Anna Fen-Yau
AF
Li
Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.|School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Yi-Ming
YM
Shyr
Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China. khhuang@vghtpe.gov.tw.|Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. khhuang@vghtpe.gov.tw.
Kuo-Hung
KH
Huang
D000230:Adenocarcinoma / Q000145:classification* / Q000473:pathology / Q000601:surgery; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D007414:Intestinal Neoplasms / Q000145:classification* / Q000473:pathology / Q000601:surgery; D008297:Male; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000145:classification* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate
Gastrecotomy; Gastric cancer; Lauren’s classification