Mechanism of failure of the Cabrol procedure: A computational fluid dynamic analysis.
Sudden failure of the Cabrol graft is common and frequently fatal. We utilised the technique of computational fluid dynamic (CFD) analysis to evaluate the mechanism of failure and potentially improve on the design of the Cabrol procedure. CFD analysis of the classic Cabrol procedure and a number of its variants was performed. Results from this analysis was utilised to generate further improved geometric options for the Cabrol procedure. These were also subjected to CFD analysis. All current Cabrol and variations of the Cabrol procedure are predicated by CFD analysis to be prone to graft thrombosis, secondary to stasis around the right coronary artery button. The right coronary artery flow characteristics were found to be the dominant reason for Cabrol graft failure. A simple modification of the Cabrol geometry is predicated to virtually eliminate any areas of blood stasis, and graft failure. Modification of the Cabrol graft geometry, due to CFD analysis may help reduce the incidence of graft thrombosis. A C shaped Cabrol graft with the right coronary button anastomosed to its side along its course from the aorta to the left coronary button is predicted to have the least thrombotic tendency. Clinical correlation is needed.
Department of Cardiac Surgery, Liverpool Heart and Chest Hospital, Liverpool, England, United Kingdom. Electronic address: mpoullis@hotmail.com.
M
M
Poullis
Department of Cardiac Surgery, Liverpool Heart and Chest Hospital, Liverpool, England, United Kingdom.
M
M
Pullan
D001011:Aorta / Q000503:physiopathology* / Q000601:surgery*; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006084:Graft Rejection / Q000209:etiology / Q000503:physiopathology*; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D012212:Rheology / Q000379:methods; D033081:Shear Strength; D017211:Treatment Failure; D016896:Treatment Outcome; D058017:Vascular Grafting / Q000009:adverse effects*