Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis.
Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.
Department of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan; Department of Pharmacy, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan.
Hsing-Fang
HF
Lu
Department of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Kuo-Sheng
KS
Hung
Department of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan.
Yu-Wen
YW
Hsu
Department of Anesthesiology, Taipei Medical University, Taipei, Taiwan.
Yu-Ting
YT
Tai
Department of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan.
Lin-Shan
LS
Huang
Department of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan.
Yu-Jia
YJ
Wang
Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Henry Sung-Ching
HS
Wong
Broad Institute of MIT and Harvard, Cambridge, MA, United States of America; Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, MA, United States of America.
Yi-Hsiang
YH
Hsu
Department of Clinical Pharmacy, Taipei Medical University, Taipei, Taiwan; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Wei-Chiao
WC
Chang
D000368:Aged; D015519:Bone Density / Q000235:genetics; D001842:Bone and Bones / Q000473:pathology; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D019877:Hydroxymethyl and Formyl Transferases / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D010024:Osteoporosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
C560598:FTCDNL1 protein, human; D019877:Hydroxymethyl and Formyl Transferases