Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens.
For a number of years, sirtuin enzymes have been appreciated as effective "sensors" of the cellular environment to rapidly transmit information to diverse cellular pathways. Much effort was placed into exploring their roles in human cancers and aging. However, a growing body of literature brings these enzymes to the spotlight in the field of virology. Here, we discuss sirtuin functions in the context of viral infection, which provide regulatory points for therapeutic intervention against pathogens.
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Hanna G
HG
Budayeva
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Elizabeth A
EA
Rowland
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA icristea@princeton.edu.
Ileana M
IM
Cristea
D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D037761:Sirtuins / Q000378:metabolism*; D014777:Virus Diseases / Q000276:immunology*
D037761:Sirtuins