Twelve-Month Results of a Single or Multiple Dexamethasone Intravitreal Implant for Macular Edema following Uncomplicated Phacoemulsification.
The clinical efficacy of one or two intravitreal injections of a continued deliverance dexamethasone 700 μg implant in ten patients with persistent macular edema following uncomplicated phacoemulsification was evaluated. Complete ophthalmological examination and spectral domain optical coherence tomography were carried out. Follow-up was at day 7 and months 1, 2, 4, 6, 8, and 12. At baseline mean best corrected visual acuity was 62 Early Treatment Diabetic Retinopathy Study Chart letters, which showed statistically significant improvement at each follow-up, except at month 6, to reach 79 letters at month 12 (P = 0.018). Prior to treatment mean central foveal thickness was 622 μm, which showed statistically significant improvement at each follow-up to reach a mean value of 282 μm (P = 0.012) at month 12. Five patients received a second dexamethasone implant at month 7. Two patients were excluded from the study at months 4 and 8. Intraocular pressure remained stable during the study period with the exception of mild increase in two patients requiring topical therapy. In conclusion there was statistically significant improvement of best corrected visual acuity and mean central foveal thickness with one or two intravitreal dexamethasone implants over 12 months.
Ophthalmology Unit, DAI Testa/Collo, Azienda Policlinico Umberto I, University of Rome "Sapienza", Viale del Policlinico 155, 00161 Rome, Italy.
Solmaz
S
Abdolrahimzadeh
Ophthalmology Unit, Sant'Andrea Hospital, NESMOS Department, University of Rome "Sapienza", Via di Grottarossa 1035-1039, 00189 Rome, Italy.
Vito
V
Fenicia
Ophthalmology Unit, Sant'Andrea Hospital, NESMOS Department, University of Rome "Sapienza", Via di Grottarossa 1035-1039, 00189 Rome, Italy.
Maurizio
M
Maurizi Enrici
Ophthalmology Unit, Sant'Andrea Hospital, NESMOS Department, University of Rome "Sapienza", Via di Grottarossa 1035-1039, 00189 Rome, Italy.
Pasquale
P
Plateroti
Ophthalmology Unit, Sant'Andrea Hospital, NESMOS Department, University of Rome "Sapienza", Via di Grottarossa 1035-1039, 00189 Rome, Italy.
Dora
D
Cianfrone
Ophthalmology Unit, Sant'Andrea Hospital, NESMOS Department, University of Rome "Sapienza", Via di Grottarossa 1035-1039, 00189 Rome, Italy.
Santi Maria
SM
Recupero
D000368:Aged; D000369:Aged, 80 and over; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D007429:Intraocular Pressure; D058449:Intravitreal Injections / Q000379:methods*; D008269:Macular Edema / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
D005938:Glucocorticoids; D003907:Dexamethasone