[Association of prognosis with insulin-like growth factor receptor type I expression in gastric cancer patients: a meta-analysis].
OBJECTIVE
To systemically evaluate the relationship between the expression of insulin-like growth factor receptor type I (IGF-1R) and prognosis in gastric cancer (GC) patients.


METHODS
A literature search was conducted from PubMed, EMBASE, Web of Science, CNKI, Wanfang and VIP databases to retrieve the clinical studies relevant to IGF-1R expression and its prognostic value in GC patients. Meta-analysis was performed using STATA 12.0 software. The methodology was assessed according to the European Lung Cancer Working Party Quality Scale for Biological Prognostic Factors for Lung Cancer. The quality of studies was assessed using the Newcastle-Ottawa scale.


RESULTS
Four eligible studies including 685 patients were enrolled for this meta-analysis. Analysis results suggested that up-regulation of IGF-1R in GC patients was significantly associated with TNM staging (OR=5.20, 95%CI:1.12 to 24.15, P=0.035), lymph node metastasis(OR=8.24, 95%CI:2.68 to 25.34, P=0.000) and distant metastasis(OR=17.34, 95%CI:6.52 to 46.15, P=0.000). Moreover, up-regulated IGF-1R expression was significantly associated with poor overall survival of gastric cancer patients(HR=2.63, 95% CI:1.29 to 5.40, Z=2.64, P=0.008).


CONCLUSIONS
High IGF-1R expression may be an adverse prognostic factor in gastric cancer patients.
Department of General Surgery, Chinese's Liberation Army General Hospital, 28 Fuxing Road, Beijing 100853, China. chenlinbj@vip.sina.com.
Yunhe
Y
Gao
Jianxin
J
Cui
Hongqing
H
Xi
Weisong
W
Shen
Kecheng
K
Zhang
Jiyang
J
Li
Wenquan
W
Liang
Chong
C
Hu
Bo
B
Wei
Lin
L
Chen
D014408:Biomarkers, Tumor; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D017526:Receptor, IGF Type 1; D017451:Receptors, Somatomedin / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; C000597236:IGF1R protein, human; D017451:Receptors, Somatomedin; D017526:Receptor, IGF Type 1