The Role of Reelin Signaling in Alzheimer's Disease.
Alzheimer's disease (AD) is the most common causes of age-related dementia. It is characterized by the deposition of amyloid-beta peptide and neurofibrillary tangles, as well as neuronal death and synaptic loss. Reelin is an extracellular glycoprotein which performs diverse roles in the developing and adult brain, including regulation of neuronal migration, dendritogenesis, synapse development, hippocampal synaptic plasticity, and learning and memory. Altered expression and glycosylation patterns of Reelin in cerebrospinal and cortical extracts have been reported in AD. Accumulating studies have investigated the molecular mechanism by which Reelin, its receptors, and downstream signaling proteins may contribute to the pathophysiology of AD. However, the molecular mechanisms by which Reelin and its downstream signal transduction contribute to the pathogenesis of AD remain still largely unknown. In the present review, we briefly summarize the current knowledge and recent findings related to the molecular link between Reelin dysfunction and AD-related neuropathology.
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
Nan-Nan
NN
Yu
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
Meng-Shan
MS
Tan
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.|Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Jin-Tai
JT
Yu
Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China. xieanmu@163.com.
An-Mu
AM
Xie
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China. dr.tanlan@163.com.
Lan
L
Tan
D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000378:metabolism*; D015398:Signal Transduction; D016875:tau Proteins / Q000378:metabolism
D016229:Amyloid beta-Peptides; D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D016875:tau Proteins; C000717127:RELN protein, human; D012697:Serine Endopeptidases
Alzheimer’s disease; Amyloid-beta peptide; Neurofibrillary tangles; Reelin