MicroRNA-107: a novel promoter of tumor progression that targets the CPEB3/EGFR axis in human hepatocellular carcinoma.
MicroRNAs (miRNAs) are dysregulated in many types of malignancies, including human hepatocellular carcinoma (HCC). MiR-107 has been implicated in several types of cancer regulation; however, relatively little is known about miR-107 in human HCC. In the present study, we showed that the overexpression of miR-107 accelerates the tumor progression of HCC in vitro and in vivo through its new target gene, CPEB3. Furthermore, our results demonstrated that CPEB3 is a newly discovered tumor suppressor that acts via the EGFR pathway. Therefore, our study demonstrates that the newly discovered miR-107/CPEB3/EGFR axis plays an important role in HCC progression and might represent a new potential therapeutic target for HCC treatment.
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
Chen-Dan
CD
Zou
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
Wei-Ming
WM
Zhao
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
Xiao-Na
XN
Wang
Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Qiang
Q
Li
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
Hui
H
Huang
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
Wan-Peng
WP
Cheng
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
Jian-Feng
JF
Jin
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
He
H
Zhang
Academy of Traditional Chinese Medicines, Harbin, China.
Ming-Juan
MJ
Wu
Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Sheng
S
Tai
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
Chao-Xia
CX
Zou
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.|Heilongjiang Academy of Medical Science, Harbin, China.
Xu
X
Gao
D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D018450:Disease Progression; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics*; D009362:Neoplasm Metastasis; D034622:RNA Interference; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014183:Transplantation, Heterologous; D047368:Tumor Burden / Q000235:genetics
D020413:3' Untranslated Regions; C513866:CPEB3 protein, human; C549045:MIRN107 microRNA, human; D035683:MicroRNAs; D016601:RNA-Binding Proteins; C512478:EGFR protein, human; D066246:ErbB Receptors
CPEB3; EGFR; hepatocellular carcinoma; microRNA; microRNA-107