Larvicidal and acetylcholinesterase inhibitory activities of apiaceae plant essential oils and their constituents against aedes albopictus and formulation development.
This study evaluated the larvicidal activity of 12 Apiaceae plant essential oils and their components against the Asian tiger mosquito, Aedes albopictus, and the inhibition of acetylcholine esterase with their components. Of the 12 plant essential oils tested, ajowan (Trachyspermum ammi), caraway seed (Carum carvi), carrot seed (Daucus carota), celery (Apium graveolens), cumin (Cuminum cyminum), dill (Anethum graveolens), and parsley (Petroselinum sativum) resulted in >90% larval mortality when used at 0.1 mg/mL. Of the compounds identified, α-phellandrene, α-terpinene, p-cymene, (-)-limonene, (+)-limonene, γ-terpinene, cuminaldehyde, neral, (S)-+-carvone, trans-anethole, thymol, carvacrol, myristicin, apiol, and carotol resulted in >80% larval mortality when used at 0.1 mg/mL. Two days after treatment, 24.69, 3.64, and 12.43% of the original amounts of the celery, cumin, and parsley oils, respectively, remained in the water. Less than 50% of the original amounts of α-phellandrene, 1,8-cineole, terpinen-4-ol, cuminaldehyde, and trans-antheole were detected in the water at 2 days after treatment. Carvacrol, α-pinene, and β-pinene inhibited the activity of Ae. albopictus acetylcholinesterase with IC50 values of 0.057, 0.062, and 0.190 mg/mL, respectively. A spherical microemulsion of parsley essential oil-loaded poly(vinyl alcohol) (PVA) was prepared, and the larvicidal activity of this formulation was shown to be similar to that of parsley oil.
Lifetree Biotech Company, Ltd., Maesonggosaek-ro, Kwonsun-gu, Suwon, Gyeonggido 441-813, Republic of Korea.
Seon-Mi
SM
Seo
Division of Forest Insect Pests and Diseases, Korea Forest Research Institute , Seoul 130-712, Republic of Korea.
Chan-Sik
CS
Jung
Gyeongnam Department of Environmental Toxicology and Chemistry, Korea Institute of Toxicology , Jin-Ju 660-844, Gyeongnam, Republic of Korea.
Jaesoon
J
Kang
Hyo-Rim
HR
Lee
Division of Forest Insect Pests and Diseases, Korea Forest Research Institute , Seoul 130-712, Republic of Korea.
Sung-Woong
SW
Kim
Jinho
J
Hyun
Il-Kwon
IK
Park
D000110:Acetylcholinesterase / Q000378:metabolism; D000330:Aedes / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D019476:Insect Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D008297:Male; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D019476:Insect Proteins; D007306:Insecticides; D009822:Oils, Volatile; D000110:Acetylcholinesterase
Apiaceae plant essential oils; Asian tiger mosquito; acetylchholine esterase inhibition; larvicidal activity; residue in water