Two-dimensional speckle tracking for the assessment of coronary artery disease during dobutamine stress echo: clinical tool or merely research method.
BACKGROUND
Two-dimensional speckle tracking provides valuable information for regional wall motion abnormalities. The purpose of this study was to determine the diagnostic value of left ventricular longitudinal strain and torsion to diagnose coronary artery disease during dobutamine stress echocardiography.


METHODS
We studied 100 patients (mean age 60.8 ± 10.7 years, 72 male) with known or suspected coronary artery disease, excluding those with prior history of transmural infraction. All of them underwent dobutamine stress echo and coronary angiography within one month. Wall-motion score index, left ventricular global longitudinal strain and torsion were measured at rest and peak stress. Additionally, the respective differences between rest and stress were also calculated. Optimal cut-offs were derived from receiver operating characteristic curves for strain and torsion values.


RESULTS
Mean left ventricular ejection fraction was 55 ± 5.4 %. Coronary angiography revealed significant lesions in 67 patients. Values regarding sensitivity, and specificity for wall motion score index difference were 78 % and 88 % respectively (area under curve 0.84). Global longitudinal strain difference (median 0.5 %) illustrated 81 % sensitivity and 72 % specificity for disease detection (area under curve 0.80, cut-off value ≤0 %). The respective values for torsion difference (median 4.7°) were 81 % and 82 % (area under curve 0.76, cut-off value ≤6.5°). Combination of wall motion score index difference and torsion difference for disease detection showed 91 % sensitivity and 79 % specificity (area under curve 0.85).


CONCLUSIONS
The implementation of speckle tracking during dobutamine stress echo could serve as an adjunct method for coronary artery disease assessment, providing quantitative diagnostic information.
1st Cardiology Department, Hippokration Hospital, Athens Medical School, 114 Vas. Sophias Ave, Athens, Greece. dina.aggeli@gmail.com.
Constantina
C
Aggeli
1st Cardiology Department, Hippokration Hospital, Athens Medical School, 114 Vas. Sophias Ave, Athens, Greece.
Stauroula
S
Lagoudakou
1st Cardiology Department, Hippokration Hospital, Athens Medical School, 114 Vas. Sophias Ave, Athens, Greece.
Ioannis
I
Felekos
1st Cardiology Department, Hippokration Hospital, Athens Medical School, 114 Vas. Sophias Ave, Athens, Greece.
Vasiliki
V
Panagopoulou
1st Cardiology Department, Hippokration Hospital, Athens Medical School, 114 Vas. Sophias Ave, Athens, Greece.
Stellios
S
Kastellanos
1st Cardiology Department, Hippokration Hospital, Athens Medical School, 114 Vas. Sophias Ave, Athens, Greece.
Konstantinos
K
Toutouzas
1st Cardiology Department, Hippokration Hospital, Athens Medical School, 114 Vas. Sophias Ave, Athens, Greece.
George
G
Roussakis
1st Cardiology Department, Hippokration Hospital, Athens Medical School, 114 Vas. Sophias Ave, Athens, Greece.
Dimitris
D
Tousoulis
D003324:Coronary Artery Disease / Q000150:complications* / Q000000981:diagnostic imaging*; D004452:Echocardiography / Q000379:methods*; D025401:Echocardiography, Stress / Q000379:methods*; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012107:Research Design; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology*