Healthcare utilization and costs associated with tyrosine kinase inhibitor switching in patients with chronic myeloid leukemia.
Differences in healthcare utilization and costs were examined in chronic myeloid leukemia (CML) patients experiencing first-, second- and third-line tyrosine kinase inhibitor (TKI) therapy. Three CML cohorts were identified from the Truven Health MarketScan® database: No-Switch Cohort (NSc) = did not switch from first-line; One-Switch Cohort (OSc) = switched from first- to second-line only; Two-Switch Cohort (TSc) = switched to second- and then third-line. A total of 3510 patients were identified (mean = 54%; age = 55.8 years). NSc comprised 81% of the sample, OSc comprised 15% and 4% were in the TSc. First-line utilization/costs were significantly higher in the OSc/TSc compared to the NSc. Second-line hospital/outpatient visits and costs were higher in TSc compared to OSc. TSc experienced a significant cost increase from first- to second-line ($4226.46), twice that of OSc ($2488.03). TKI switching is associated with a substantial increase in healthcare utilization and costs, particularly for patients who switch twice.
a Fox Chase Cancer Center , Philadelphia , PA , USA ;
Patricia
P
Kropf
b Global Health Economics & Outcomes Research , Teva Pharmaceuticals , Frazer , PA , USA ;
Gisoo
G
Barnes
b Global Health Economics & Outcomes Research , Teva Pharmaceuticals , Frazer , PA , USA ;
Boxiong
B
Tang
b Global Health Economics & Outcomes Research , Teva Pharmaceuticals , Frazer , PA , USA ;
Ashutosh
A
Pathak
c Fels Institute for Cancer Research , Temple University School of Medicine , Philadelphia , PA , USA.
Jean-Pierre J
JP
Issa
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000191:economics*; D016208:Databases, Factual; D057915:Drug Substitution; D005260:Female; D017048:Health Care Costs; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D047428:Protein Kinase Inhibitors / Q000191:economics*; D019233:Retreatment; D017211:Treatment Failure
D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors
Tyrosine kinase inhibitors; burden; chronic myeloid leukemia; costs; healthcare resource utilization; switching; treatment failure