Panobinostat for the treatment of multiple myeloma: the evidence to date.
Multiple myeloma is a malignancy involving plasma cell proliferation within the bone marrow. Survival of patients diagnosed with myeloma has significantly improved in the last decade, following the approval of novel agents. Despite great strides achieved in the management of multiple myeloma, it is still considered an incurable disease as the majority of patients relapse after initiation of therapy. Additionally, the duration of response generally decreases with an increasing number of therapy lines. The need to overcome resistance to therapy dictates research into more potent agents and those with novel mechanisms of action. A therapeutic option for relapsed/refractory myeloma includes histone deacetylase inhibition. Various histone deacetylase inhibitors, including the newly approved panobinostat, are currently under evaluation in this setting. Panobinostat for multiple myeloma is used in combination with other potent therapeutic agents, such as proteasome inhibitors and steroids. Ongoing research evaluating other panobinostat-containing regimens will provide additional insight into its place in myeloma management.
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Hanna
H
Bailey
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA ; Department of Pharmacotherapy, Pharmacotherapy Outcomes Research Center, University of Utah, Salt Lake City, UT, USA.
David D
DD
Stenehjem
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Sunil
S
Sharma
HDAC inhibitor; LBH589; multiple myeloma; panobinostat; relapsed