Vascular responsiveness determined by near-infrared spectroscopy measures of oxygen saturation.
Vascular impairments at the macro- and microcirculatory levels are associated with increased risk for cardiovascular disease. Flow-mediated dilation (FMD) is currently the most widely used method for non-invasive assessment of vascular endothelial function. Recently, near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2) have been used to characterize the dynamic response of local tissue perfusion to a brief period of ischaemia. The purpose of the present study was to establish correlations between the reperfusion rate of StO2 and FMD. Ultrasound-derived FMD was quantified after 5 min of distal cuff occlusion of the popliteal artery in 20 healthy young men (26 ± 3 years old). Triplicate measurements of end-diastolic arterial diameter were made every 15 s after cuff release, and FMD response was calculated as the greatest percentage change in diameter from baseline (%FMD). The StO2 was measured using NIRS throughout the duration of each test. Two consecutive FMD tests were performed, separated by 30 min of rest, and were averaged for %FMD and StO2. The %FMD was significantly correlated with the reperfusion slope of StO2 after cuff release (slope 2 StO2; r = 0.63, P = 0.003). In conclusion, the present study established a correlation between slope 2 StO2 and %FMD in healthy young men. These data suggest that NIRS-derived slope 2 StO2 can be used as a measure of vascular endothelial function.
Canadian Centre for Activity and Aging, The University of Western Ontario, London, ON, Canada.|School of Kinesiology, The University of Western Ontario, London, ON, Canada.
Kaitlin M
KM
McLay
Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
Federico Y
FY
Fontana
Canadian Centre for Activity and Aging, The University of Western Ontario, London, ON, Canada.|School of Kinesiology, The University of Western Ontario, London, ON, Canada.
Josh P
JP
Nederveen
Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
Federico F
FF
Guida
Canadian Centre for Activity and Aging, The University of Western Ontario, London, ON, Canada.|School of Kinesiology, The University of Western Ontario, London, ON, Canada.
Donald H
DH
Paterson
Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
Silvia
S
Pogliaghi
Canadian Centre for Activity and Aging, The University of Western Ontario, London, ON, Canada.|School of Kinesiology, The University of Western Ontario, London, ON, Canada.|Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada.
Juan M
JM
Murias
D000328:Adult; D001808:Blood Vessels / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology; D010100:Oxygen / Q000032:analysis; D010101:Oxygen Consumption / Q000502:physiology*; D011150:Popliteal Artery / Q000378:metabolism; D015424:Reperfusion; D019265:Spectroscopy, Near-Infrared; D014664:Vasodilation / Q000502:physiology; D055815:Young Adult
D010100:Oxygen