Capture of reactive monophosphine-ligated palladium(0) intermediates by mass spectrometry.
A long-sought-after reactive monophosphine-ligated palladium(0) intermediate, Pd(0)L (L = phosphine ligand), was detected for the first time from the activation of the Buchwald precatalyst with base. The detection was enabled using desorption electrospray ionization mass spectrometry (DESI-MS) in combination with online reaction monitoring. The subsequent oxidative addition of Pd(0)L with aryl halide and C-N coupling with amine via reductive elimination was also probed using DESI-MS.
Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Edison Biotechnology Institute, Ohio University , Athens, Ohio 45701, United States.
Qiuling
Q
Zheng
Department of Process and Analytical Chemistry and Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
Yong
Y
Liu
Department of Process and Analytical Chemistry and Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
Qinghao
Q
Chen
Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Edison Biotechnology Institute, Ohio University , Athens, Ohio 45701, United States.
Meihong
M
Hu
Department of Process and Analytical Chemistry and Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
Roy
R
Helmy
Department of Process and Analytical Chemistry and Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
Edward C
EC
Sherer
Department of Process and Analytical Chemistry and Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc. , Rahway, New Jersey 07065, United States.
Christopher J
CJ
Welch
Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Edison Biotechnology Institute, Ohio University , Athens, Ohio 45701, United States.
Hao
H
Chen