Natural Killer Cell Memory.
Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of T and B cells. In this review, we discuss evidence of NK cell memory and the mechanisms involved in the generation and survival of these innate lymphocytes.
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Timothy E
TE
O'Sullivan
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: sunj@mskcc.org.
Joseph C
JC
Sun
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: lewis.lanier@ucsf.edu.
Lewis L
LL
Lanier
D056704:Adaptive Immunity; D019264:Adoptive Transfer; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D017209:Apoptosis / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003877:Dermatitis, Contact / Q000276:immunology; D006241:Haptens / Q000276:immunology; D018398:Homeodomain Proteins / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D007249:Inflammation / Q000276:immunology; D007694:Killer Cells, Natural / Q000145:classification / Q000276:immunology* / Q000637:transplantation; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology; D008214:Lymphocytes / Q000145:classification / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D055607:Receptors, Natural Killer Cell / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology
D000956:Antigens, Viral; D016207:Cytokines; D006241:Haptens; D018398:Homeodomain Proteins; D055607:Receptors, Natural Killer Cell; C064658:RAG-1 protein
cytomegalovirus; immunological memory; natural killer cells