Effect of plasma NOx values on cardiac function in obese hypertensive and normotensive pediatric patients.
BACKGROUND
Hypertension (HT) is a major comorbidity of obesity that is associated with an increased risk of cardiovascular disease and higher mortality. The aim of our study was to evaluate cardiac function in obese hypertensive (OHT) and obese normotensive (ONT) pediatric patients and determine the effects of plasma nitric oxide (NOx) values on cardiac function, while demonstrating the role of plasma NOx in HT in obese pediatric patients.


METHODS
The study population consisted of 62 patients (27 boys, 35 girls), aged 13-18 years and 21 age-matched healthy controls. All subjects enrolled in the study underwent echocardiography (Echo) evaluation and ambulatory blood pressure monitoring for HT. Plasma NOx and biochemical values were studied in both patient groups separately.


RESULTS
Plasma NOx levels were found to be lower in the OHT group than in the ONT and control groups (p < 0.001) and to be negatively correlated with left ventricular mass index values (p < 0.05). Both the OHT and ONT groups had concentric hypertrophy of the heart.


CONCLUSIONS
Plasma NOx plays an essential role in obesity-induced HT. Concentric hypertrophy of the left ventricle was found in both the OHT and ONT groups, indicating structural deformation of the heart.
Department of Pediatric Nephrology, Gazi University School of Medicine, Konya yolu, 06500, Besevler, Ankara, Turkey. meltemileri@yahoo.com.
Meltem
M
Akcaboy
Department of Pediatric Cardiology, Gazi University School of Medicine, Ankara, Turkey.
Serdar
S
Kula
Department of Physiology, Gazi University School of Medicine, Ankara, Turkey.
Tayfun
T
Göktas
Department of Neurology, Gazi University School of Medicine, Ankara, Turkey.
Bijen
B
Nazlıel
Department of Pediatric Cardiology, Gazi University School of Medicine, Ankara, Turkey.
Semiha
S
Terlemez
Department of Pediatric Endocrinology, Gazi University School of Medicine, Ankara, Turkey.
Nurullah
N
Celik
Faculty of Science, Department of Biostatistics, Gazi University, Ankara, Turkey.
Bülent
B
Celik
Department of Pediatric Nephrology, Gazi University School of Medicine, Konya yolu, 06500, Besevler, Ankara, Turkey.
Necla
N
Buyan
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood; D063766:Pediatric Obesity / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide
Children; Echocardiography; Hypertension; Obese; Plasma NOx