Secondhand Tobacco Smoke Exposure and Lung Adenocarcinoma In Situ/Minimally Invasive Adenocarcinoma (AIS/MIA).
The aim of this study was to estimate the effect of exposure to secondhand tobacco smoke on the incidence of lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA). Data from seven case-control studies participating in the International Lung Cancer Consortium (ILCCO) were pooled, resulting in 625 cases of AIS/MIA and 7,403 controls, of whom 170 cases and 3,035 controls were never smokers. Unconditional logistic regression was used to estimate adjusted ORs (ORadj) and 95% confidence intervals (CI), controlling for age, sex, race, smoking status (ever/never), and pack-years of smoking. Study center was included in the models as a random-effects intercept term. Ever versus never exposure to secondhand tobacco smoke was positively associated with AIS/MIA incidence in all subjects (ORadj = 1.48; 95% CI, 1.14-1.93) and in never smokers (ORadj = 1.45; 95% CI, 1.00-2.12). There was, however, appreciable heterogeneity of ORadj across studies (P = 0.01), and the pooled estimates were largely influenced by one large study (40% of all cases and 30% of all controls). These findings provide weak evidence for an effect of secondhand tobacco smoke exposure on AIS/MIA incidence. Further studies are needed to assess the impact of secondhand tobacco smoke exposure using the newly recommended classification of subtypes of lung adenocarcinoma.
Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles (UCLA), Los Angeles, California.
Claire H
CH
Kim
Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah.
Yuan-Chin Amy
YC
Lee
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.
Rayjean J
RJ
Hung
The Tisch Cancer Institute and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York.
Paolo
P
Boffetta
Department of Thoracic Surgery, ShangHai Pulmonary Hospital, ShangHai, China. Mayo Clinic Cancer Center, Rochester, Minnesota.
Dong
D
Xie
Mayo Clinic Cancer Center, Rochester, Minnesota.
Jason A
JA
Wampfler
Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Michele L
ML
Cote
Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles (UCLA), Los Angeles, California.
Shen-Chih
SC
Chang
Internal Medicine, University of Genoa, Genoa, Italy. Unit of Epidemiology, Biostatistics, and Clinical Trials, IRCSS Azienda Ospedaliera Universitaria San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Donatella
D
Ugolini
Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Rome, Italy.
Monica
M
Neri
Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Loic
L
Le Marchand
Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Ann G
AG
Schwartz
Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan.
Hal
H
Morgenstern
Department of Environmental Health, Harvard University School of Public Health, Boston, Massachusetts.
David C
DC
Christiani
Mayo Clinic Cancer Center, Rochester, Minnesota.
Ping
P
Yang
Department of Epidemiology, Fielding School of Public Health, University of California at Los Angeles (UCLA), Los Angeles, California. zfzhang@ucla.edu.
Zuo-Feng
ZF
Zhang
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects / Q000706:statistics & numerical data*
D014028:Tobacco Smoke Pollution