Benign soft tissue lesions that may mimic malignancy.
Soft tissue lesions which mimic malignancy (pseudosarcomas), represent a significant diagnostic challenge for pathologists. Many features often associated with malignancy including rapid and infiltrative growth, increased cellularity and mitotic activity, and nuclear pleomorphism are present in benign and reactive conditions. This review highlights repair reactions including nodular fasciitis, proliferative fasciitis/myositis, intravascular papillary endothelial hyperplasia, and fat necrosis; lipoma and spindle cell/pleomorphic lipoma; fibroepithelial stromal (pseudosarcomatoid) polyp; phosphaturic mesenchymal tumor; and myxoma. While not inclusive of every pseudoneoplastic soft tissue lesion, this review emphasizes important diagnostic pitfalls and stresses the value of clinical, pathologic, and radiologic correlation.
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Ave MSC 908, Charleston, South Carolina 29425. Electronic address: forcucci@musc.edu.
Jessica A
JA
Forcucci
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Ave MSC 908, Charleston, South Carolina 29425.
Evelyn T
ET
Bruner
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Ave MSC 908, Charleston, South Carolina 29425.
Michael Timothy
MT
Smith
D003240:Connective Tissue Diseases / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D012983:Soft Tissue Neoplasms / Q000175:diagnosis*
Malignancy mimic; Pseudoneoplastic; Pseudosarcoma; Soft tissue