Umbilical Granuloma in a 2-Month-Old Patient: Histopathology of a Common Clinical Entity.
Umbilical granulomas are the most common anomaly of the umbilicus in neonates and infants. These lesions are characterized by an overgrowth of granulation tissue that persists at the base of the umbilical cord after its separation. Histologically, they consist of granulation tissue, which is composed of fibroblasts, inflammatory cells, and vascular endothelial cells set in an edematous stroma. Although umbilical granulomas are commonly seen clinically, there are no reports of their histopathology in the literature. The authors present the histology of this clinical finding in a 2-month-old infant, as it is important for the pathologist to be aware of this benign entity and distinguish it from other umbilical anomalies that may be of greater clinical significance.
*Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA; †Department of Pathology and Dermatology, Penn State/Hershey Medical Center, Hershey, PA; and ‡Dermatology and Pediatrics, Penn State/Hershey Medical Center, Hershey, PA.
Mary
M
Brady
Andrea B
AB
Conway
Andrea L
AL
Zaenglein
Klaus F
KF
Helm
D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D011237:Predictive Value of Tests; D014470:Umbilical Cord / Q000473:pathology* / Q000601:surgery