Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations.
We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007).
Hematology, Hospital Arnau de Vilanova, Valencia, Spain.
Aurelio
A
Lopez
Hematology, Hospital Universitario de Salamanca, Salamanca, Spain.
Maria-Victoria
MV
Mateos
Hematology, Hospital Germans Trias i Pujol, Barcelona, Spain.
Albert
A
Oriol
Hematology, Hospital Arnau de Vilanova, Valencia, Spain.
Marta
M
Valero
Hematology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Joaquín
J
Martínez
Hematology, Hospital Universitario La Fe, Valencia, Spain.
Jose Ignacio
JI
Lorenzo
Haematology, Hospital Virgen de la Concha, Zamora, Spain.
Montserrat
M
Perez
Hematology, Hospital Clínico Universitario San Carlos, Madrid, Spain.
Rafael
R
Martinez
Hematology, Hospital Universitario La Paz, Madrid, Spain.
Raquel
R
de Paz
Hematology, Hospital Santa Creu i Sant Pau, Barcelona, Spain.
Miguel
M
Granell
Hematology, Hospital Morales Meseguer, Murcia, Spain.
Felipe
F
De Arriba
Hematology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
M Jesús
MJ
Blanchard
Hematology, Hospital de Alcorcón, Madrid, Spain.
Francisco Javier
FJ
Peñalver
Hematology, Complejo Universitario, Santiago de Compostela, Spain.
Jose Luis
JL
Bello
Hematology, Hospital San Pedro de Alcántara, Caceres, Spain.
Maria Luisa
ML
Martin
Hematology, Hospital Sont Llatzer, Palma de Mallorca, Spain.
Joan
J
Bargay
Hematology, IDIBAPS, Hospital Clinic de Barcelona, Barcelona, Spain.
Joan
J
Blade
Hematology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Juan Jose
JJ
Lahuerta
Hematology, Clínica Universitaria de Navarra / CIMA, Pamplona, Spain.
Jesús F
JF
San Miguel
Hematology Service, University Hospital Doctor Peset, Avda. Gaspar Aguilar, 90, 46017 Valencia, Spain ; Universidad Católica "San Vicente Mártir", Valencia, Spain.
Javier
J
de la Rubia
Elderly patients; Patterns of relapse; Relapsed myeloma