Soluble Receptor for Advanced Glycation End Product: A Biomarker for Acute Coronary Syndrome.
The receptor of advanced glycation end products (RAGE) and its ligands are linked to the pathogenesis of coronary artery disease (CAD), and circulating soluble receptor of advanced glycation end products (sRAGE), reflecting the RAGE activity, is suggested as a potential biomarker. Elevated sRAGE levels are reported in relation to acute ischemia and this review focuses on the role of sRAGE as a biomarker for the acute coronary syndrome (ACS). The current studies demonstrated that sRAGE levels are elevated in relation to ACS, however during a very narrow time period, indicating that the time of sampling needs attention. Interestingly, activation of RAGE may influence the pathogenesis and reflection in sRAGE levels in acute and stable CAD differently.
The Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.
Louise J N
LJ
Jensen
The Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.
Allan
A
Flyvbjerg
The Medical Research Laboratory, Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark.
Mette
M
Bjerre
D054058:Acute Coronary Syndrome / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D006801:Humans; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*; D012995:Solubility
C000593871:AGER protein, human; D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products