Long-term clinical results and MRI changes after autologous chondrocyte implantation in the knee of young and active middle aged patients.
BACKGROUND
Autologous chondrocyte implantation (ACI) represents a valid surgical option for symptomatic full-thickness chondral lesions of the knee. Here we report long-term clinical and MRI results of first-generation ACI.


METHODS
Fifteen patients (mean age 21.3 years) underwent first-generation ACI for symptomatic chondral defects of the knee between 1997 and 2001. The mean size of the lesions was 5.08 cm(2) (range 2-9 cm(2)). Patients were evaluated using the International Knee Documentation Committee (IKDC) Knee Examination Form, the Tegner Activity Scale, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). High-resolution MRI was used to analyze the repair tissue with nine variables (the MOCART scoring system).


RESULTS
The mean follow-up period was 148 months (range 125-177 months). ACI resulted in substantial improvements in all clinical outcome parameters, even as much as 12 years after implantation. A significant decrease in the MOCART score was recorded at final measurement. Reoperation was required in 2 patients; failure was caused by partial detachment of the graft in both cases.


CONCLUSIONS
Autologous chondrocyte implantation is an effective and durable solution for the treatment of large, full-thickness cartilage and osteochondral lesions, even in young and active middle-aged patients. High-resolution MRI is a useful and noninvasive method for evaluating the repaired tissue.


METHODS
IV.
Department of Public Health, School of Medicine, Federico II University, Via S. Pansini 5, Bl. 12, 80131, Naples, Italy.
Donato
D
Rosa
Department of Public Health, School of Medicine, Federico II University, Via S. Pansini 5, Bl. 12, 80131, Naples, Italy. giovannibalato@gmail.com.
Giovanni
G
Balato
Department of Public Health, School of Medicine, Federico II University, Via S. Pansini 5, Bl. 12, 80131, Naples, Italy.
Giovanni
G
Ciaramella
Institute of Biostructure and Bioimaging, National Research Council, Via S. Pansini 5, 80131, Naples, Italy.
Ernesto
E
Soscia
Department of Public Health, School of Medicine, Federico II University, Via S. Pansini 5, Bl. 12, 80131, Naples, Italy.
Giovanni
G
Improta
Department of Public Health, School of Medicine, Federico II University, Via S. Pansini 5, Bl. 12, 80131, Naples, Italy.
Maria
M
Triassi
D000293:Adolescent; D000328:Adult; D001182:Arthroscopy; D002358:Cartilage, Articular / Q000000981:diagnostic imaging; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007718:Knee Injuries / Q000175:diagnosis / Q000601:surgery*; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000601:surgery*; D013997:Time Factors; D054457:Tissue Scaffolds; D055815:Young Adult
Autologous chondrocyte implantation; Chondral lesion; Knee; Magnetic resonance imaging; Osteochondritis dissecans