[Role of infection in the pathogenesis of age-related macular degeneration].
OBJECTIVE
to study the role of infectious agents in the development and progression of AMD by means of serodiagnostic assay for a complex of ophthalmotropic and opportunistic infections.


METHODS
The study enrolled 61 patients (23 men, 38 women) aged 43-68 years and diagnosed in accordance with AREDS classification of AMD. Serodiagnostic tests were performed for 11 infections with the purpose of identifying antigen-specific antibodies in the serum.


RESULTS
Activation markers of one or several infections were detected in most of the patients with AMD.


CONCLUSIONS
Herpes viruses (HSV1 and CMV) along with some opportunistic pathogens are important factors in the pathogenesis of AMD, thereby, specific treatment should be performed in these patients.
Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
O S
OS
Slepova
Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
E A
EA
Eremeeva
Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
M V
MV
Ryabina
Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
E S
ES
Sorozhkina
D000328:Adult; D000368:Aged; D015817:Eye Infections / Q000150:complications / Q000382:microbiology; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests / Q000379:methods; D013223:Statistics as Topic