Phosphoric acid-catalyzed asymmetric classic Passerini reaction.
An efficient enantioselective classic three-component Passerini reaction with a broad substrate scope in the presence of a chiral phosphoric acid catalyst has been developed. This represents the general example for classic three-component Passerini reaction with good to excellent enantioselectivies involving aromatic aldehydes and the bulky pivalaldehyde under mild reaction conditions. The feature of this method is highlighted by using a chiral phosphoric acid to activate carboxylic acid, aldehyde, and isocyanide for the facile construction of widely useful complex compounds.
Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
Jian
J
Zhang
Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
Shao-Xia
SX
Lin
Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
Dao-Juan
DJ
Cheng
Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
Xin-Yuan
XY
Liu
Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, China.
Bin
B
Tan