Amenorrhea, ptosis and high insulin requirement in a young girl.
Lipodystrophy is an uncommon condition leading to excessive insulin requirement and menstrual abnormalities in young girls with diabetes. Neurological symptoms are uncommon in patients of generalized or partial lipodystrophy. We recently encountered a young girl, who presented with high insulin requirement, amenorrhea and neurological symptoms. Detailed evaluation led to the diagnosis of congenital lipodystrophy and we describe the same in this report. We also highlight the atypical features of the congenital lipodystrophy and the reasons for the excessive insulin requirement in patients with diabetes mellitus.
Department of Endocrinology, Command Hospital, Chandimandir, Haryana, India. Electronic address: hariendo@rediffmail.com.
K V S
KV
Hari Kumar
Department of Medicine, AFMC, Pune 411040, India.
Sandeep
S
Kumar
D000293:Adolescent; D000568:Amenorrhea / Q000150:complications / Q000473:pathology*; D001763:Blepharoptosis / Q000150:complications / Q000473:pathology*; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D052497:Lipodystrophy, Congenital Generalized / Q000175:diagnosis
D007328:Insulin
Berardinelli-Seip syndrome; Diabetes; Insulin resistance; Lipodystrophy; Puberty