Diagnosis of intrachromosomal amplification of chromosome 21 (iAMP21) by molecular cytogenetics in pediatric acute lymphoblastic leukemia.
Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with poor prognosis that should be investigated in routine practice. Single-nucleotide polymorphism (SNP)-array provides a useful method to detect such cases showing a highly characteristic profile.
Medical Cytogenetics Institute, Jeanne de Flandre Hospital Lille, France ; Laboratory of Hematology, Biology and Pathology Center Lille, France ; INSERM UMR-S 1172, Cancer Research Institute Lille, France.
Nicolas
N
Duployez
Medical Cytogenetics Institute, Jeanne de Flandre Hospital Lille, France ; INSERM UMR-S 1172, Cancer Research Institute Lille, France.
Elise
E
Boudry-Labis
Laboratory of Hematology, Biology and Pathology Center Lille, France.
Gauthier
G
Decool
Laboratory of Hematology, Biology and Pathology Center Lille, France.
Guillaume
G
Grzych
Laboratory of Hematology, Biology and Pathology Center Lille, France.
Nathalie
N
Grardel
Pediatric Hematology Department, Jeanne de Flandre Hospital Lille, France.
Wadih
W
Abou Chahla
Laboratory of Hematology, Biology and Pathology Center Lille, France ; INSERM UMR-S 1172, Cancer Research Institute Lille, France.
Claude
C
Preudhomme
Medical Cytogenetics Institute, Jeanne de Flandre Hospital Lille, France ; INSERM UMR-S 1172, Cancer Research Institute Lille, France.
Catherine
C
Roche-Lestienne
BCP-ALL; RUNX1; SNP-array; cytogenetics; iAMP21