Poly-α,β-Polyasparthydrazide-Based Nanogels for Potential Oral Delivery of Paclitaxel: In Vitro and In Vivo Properties.
A family of nanogel drug carriers has been designed to enhance the oral absorption of paclitaxel (PTX). The PAHy-based nanogels were prepared by the interpenetration of poly-α,β-polyasparthydrazide (PAHy) chains and dicarboxyl-poly (ethylene glycol) (CPEG), forming a smart chain network. The PAHy-based nanogels were characterized by Fourier Transform Infrared Spectroscopy (FT-IR), dynamic light scattering (DLS), X-ray diffraction (XRD) and high performance liquid chromatography (HPLC). The adhesion and retention properties of fluorescein isothiocyanate (FITC)-nanogels in vivo were investigated using an in vivo imaging system and confocal laser scanning microscopy (CLSM). The smart nanogels had a particle size of -200 nm, increased the degree and rate of release, and spent over 12 h in the gastrointestinal tract. They also produced excellent adhesion, permeability and retention (APR) effects and increased oral absorption, confirming their use as potential sustained-release carriers for the oral delivery of the hydrophobic anticancer agent PTX.
Jingwen
J
Guo
Mingxin
M
Ma
Di
D
Chang
Qiang
Q
Zhang
Chen
C
Zhang
Yang
Y
Yue
Jia
J
Liu
Siling
S
Wang
Tongying
T
Jiang
D000284:Administration, Oral; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005782:Gels; D006834:Hydrazines / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007408:Intestinal Absorption; D008297:Male; D049329:Nanostructures / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D004337:Drug Carriers; D005782:Gels; D006834:Hydrazines; D009757:Nylons; C114303:alpha,beta-polyasparthydrazide; D011092:Polyethylene Glycols; D017239:Paclitaxel