Tardive dyskinesia occurring in a young woman after withdrawal of an atypical antipsychotic drug.
Tardive dyskinesia (TD) is one of the most serious and disturbing side-effects of dopamine receptor antagonists. It affects 20-50% of patients on long-term antipsychotic therapy. The pathophysiology of TD remains poorly understood, and treatment is often challenging. Here, we present a 32-year-old woman presenting with a 9-month history of TD occurring after risperidone withdrawal, and characterized almost exclusively by tongue protrusion. After being seen by different specialties and undergoing multiple investigations, she was eventually correctly diagnosed with TD by a specialist team and successfully treated with amantadine. Vigilance and awareness of this condition and its risk factors are required to make the correct diagnosis, especially in cases with unusual presentations caused by atypical antipsychotics, and treatment can be challenging.
Psychiatry Department, King Khalid University Hospital, King Saud University, PO Box 7805, Riyadh 11472, Kingdom of Saudi Arabia. Tel. +966 (11) 4671717. Fax. +966 (11) 4672571. E-mail: malblowi@ksu.edu.sa.
Mohammed A
MA
Alblowi
Fahad D
FD
Alosaimi
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009069:Movement Disorders / Q000209:etiology*; D011618:Psychotic Disorders / Q000188:drug therapy; D018967:Risperidone / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D014059:Tongue
D014150:Antipsychotic Agents; D018967:Risperidone