Inflammasome/IL-1β Responses to Streptococcal Pathogens.
Inflammation mediated by the inflammasome and the cytokine IL-1β are some of the earliest and most important alarms to infection. These pathways are responsive to the virulence factors that pathogens use to subvert immune processes, and thus are typically activated only by microbes with potential to cause severe disease. Among the most serious human infections are those caused by the pathogenic streptococci, in part because these species numerous strategies for immune evasion. Since the virulence factor armament of each pathogen is unique, the role of IL-1β and the pathways leading to its activation varies for each infection. This review summarizes the role of IL-1β during infections caused by streptococcal pathogens, with emphasis on emergent mechanisms and concepts countering paradigms determined for other organisms.
Department of Pediatrics, University of California San Diego , La Jolla, CA , USA.
Christopher N
CN
LaRock
Department of Pediatrics, University of California San Diego , La Jolla, CA , USA ; Skaggs School of Medicine and Pharmaceutical Sciences, University of California San Diego , La Jolla, CA , USA.
Victor
V
Nizet
IL-1β; Streptococcus; caspase-1; inflammasome; pyroptosis