A Comparison of Structural Brain Imaging Findings in Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder.
ASD and ADHD are regarded as distinct disorders in the current DSM-5. However, recent research and the RDoC initiative are recognizing considerable overlap in the clinical presentation of ASD, ADHD, and other neurodevelopmental disorders. In spite of numerous neuroimaging findings in ASD and ADHD, the extent to which either of the above views are supported remains equivocal. Here we compare structural MRI and DTI literature in ASD and ADHD. Our main findings reveal both distinct and shared neural features. Distinct expressions were in total brain volume (ASD: increased volume, ADHD: decreased volume), amygdala (ASD: overgrowth, ADHD: normal), and internal capsule (ASD: unclear, ADHD: reduced FA in DTI). Considerable overlap was noted in the corpus callosum and cerebellum (lower volume in structural MRI and decreased FA in DTI), and superior longitudinal fasciculus (reduced FA in DTI). In addition, we identify brain regions which have not been studied in depth and require more research. We discuss relationships between brain features and symptomatology. We conclude by addressing limitations of current neuroimaging research and offer approaches that account for clinical heterogeneity to better distinguish brain-behavior relationships.
Autism and Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Lewisburg, PA, 17837, USA. ccdougherty@geisinger.edu.
Chase C
CC
Dougherty
Department of Psychology, Bucknell University, 701 Moore Avenue, Lewisburg, PA, 17837, USA. dwevans@bucknell.edu.
David W
DW
Evans
Autism and Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Lewisburg, PA, 17837, USA. smyers1@geisinger.edu.
Scott M
SM
Myers
Autism and Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Lewisburg, PA, 17837, USA. gjmoore@geisinger.edu.|Institute for Advanced Application, Geisinger Health System, 100 N Academy Ave, Danville, PA, 17822, USA. gjmoore@geisinger.edu.|Department of Radiology, Geisinger Health System, Danville, PA, 17822, USA. gjmoore@geisinger.edu.
Gregory J
GJ
Moore
Autism and Developmental Medicine Institute, Geisinger Health System, 120 Hamm Drive, Lewisburg, PA, 17837, USA. ammichael@geisinger.edu.|Institute for Advanced Application, Geisinger Health System, 100 N Academy Ave, Danville, PA, 17822, USA. ammichael@geisinger.edu.
Andrew M
AM
Michael
D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology*; D000067877:Autism Spectrum Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
Attention-deficit hyperactivity disorder; Autism spectrum disorder; Brain imaging; DTI; MRI; Neurodevelopmental disorders