Performance Assessment of Internal Quality Control (IQC) Products in Blood Transfusion Compatibility Testing in China.
Internal quality control (IQC) is a critical component of laboratory quality management, and IQC products can determine the reliability of testing results. In China, given the fact that most blood transfusion compatibility laboratories do not employ IQC products or do so minimally, there is a lack of uniform and standardized IQC methods. To explore the reliability of IQC products and methods, we studied 697 results from IQC samples in our laboratory from 2012 to 2014. The results showed that the sensitivity and specificity of the IQCs in anti-B testing were 100% and 99.7%, respectively. The sensitivity and specificity of the IQCs in forward blood typing, anti-A testing, irregular antibody screening, and cross-matching were all 100%. The reliability analysis indicated that 97% of anti-B testing results were at a 99% confidence level, and 99.9% of forward blood typing, anti-A testing, irregular antibody screening, and cross-matching results were at a 99% confidence level. Therefore, our IQC products and methods are highly sensitive, specific, and reliable. Our study paves the way for the establishment of a uniform and standardized IQC method for pre-transfusion compatibility testing in China and other parts of the world.
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Gui-Ping
GP
Xu
The Department of Laboratory Medicine, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Li-Fang
LF
Wu
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Jing-Jing
JJ
Li
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Qi
Q
Gao
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Zhi-Dong
ZD
Liu
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Qiong-Hua
QH
Kang
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Yi-Jun
YJ
Hou
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Luo-Chuan
LC
Zhang
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Xiao-Mei
XM
Hu
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Jie
J
Li
Transfusion Department, the Second Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Juan
J
Zhang
D001773:Blood Cells / Q000166:cytology; D001803:Blood Transfusion / Q000592:standards*; D002681:China; D006403:Hematologic Tests / Q000639:trends*; D006801:Humans; D007753:Laboratories / Q000592:standards*; D011786:Quality Control; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity