Propofol requirement for induction of unconsciousness is reduced in patients with Parkinson's disease: a case control study.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, but whether the neurodegenerative process influences the pharmacodynamics of propofol remains unclear. We aimed to evaluate the effect of PD on pharmacodynamics of propofol. A total of 31 PD patients undergoing surgical treatment (PD group) and 31 pair-controlled non-PD patients undergoing intracranial surgery (NPD group) were recruited to investigate the propofol requirement for unconsciousness induction. Unconsciousness was induced in all patients with target-controlled infusion of propofol. The propofol concentration at which unconsciousness was induced was compared between the two groups. EC50 and EC95 were calculated as well. Demographic data, bispectral index, and hemodynamic values were comparable between PD and NPD groups. The mean target concentration of propofol when unconsciousness was achieved was 2.32 ± 0.38 μg/mL in PD group, which was significantly lower than that in NPD group (2.90 ± 0.35 μg/mL). The EC50 was 2.05 μg/mL (95% CI: 1.85-2.19 μg/mL) in PD group, much lower than the 2.72 μg/mL (95% CI: 2.53-2.88 μg/mL) in NPD group. In conclusion, the effective propofol concentration needed for induction of unconsciousness in 50% of patients is reduced in PD patients. (This trial is registered with NCT01998204.).
Department of Anesthesiology and Intensive Care Medicine, The Second Military Medical University, 168 Changhai Road, Shanghai 200433, China ; Department of Anesthesiology, Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian 350001, China.
Xiao-ping
XP
Xu
Department of Anesthesiology and Intensive Care Medicine, The Second Military Medical University, 168 Changhai Road, Shanghai 200433, China.
Xi-ya
XY
Yu
Department of Neurosurgery, Changhai Hospital, The Second Military Medical University, 168 Changhai Road, Shanghai 200433, China.
Xi
X
Wu
Department of Neurosurgery, Changhai Hospital, The Second Military Medical University, 168 Changhai Road, Shanghai 200433, China.
Xiao-wu
XW
Hu
Department of Neurosurgery, Changhai Hospital, The Second Military Medical University, 168 Changhai Road, Shanghai 200433, China.
Jian-chun
JC
Chen
Department of Anesthesiology and Intensive Care Medicine, The Second Military Medical University, 168 Changhai Road, Shanghai 200433, China.
Jin-bao
JB
Li
Department of Anesthesiology and Intensive Care Medicine, The Second Military Medical University, 168 Changhai Road, Shanghai 200433, China.
Jia-Feng
JF
Wang
Department of Anesthesiology and Intensive Care Medicine, The Second Military Medical University, 168 Changhai Road, Shanghai 200433, China.
Xiao-ming
XM
Deng
D018681:Anesthetics, General / Q000008:administration & dosage; D016022:Case-Control Studies; D003243:Consciousness / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology; D015742:Propofol / Q000008:administration & dosage*; D016896:Treatment Outcome
D018681:Anesthetics, General; D015742:Propofol