Features of children with positive celiac serology and type 1 diabetes mellitus.
Prior studies have reported disparate clinical presentations between children with celiac disease and type 1 diabetes mellitus and those with celiac disease alone. Studies focusing on differences in endoscopic and histopathological findings, however, are limited. We reviewed children aged 2-18 years, presenting for an initial evaluation between January 2000 and December 2010. Data on medical history, serologic markers, upper endoscopy, and histopathology were collected. Only the children with positive celiac serology who had upper endoscopy performed within 3 months of the initial visit were included. We identified 294 children who fulfilled the criteria, 21 of whom had diagnosed type 1 diabetes mellitus. Diabetic children were more likely to have absence of gastrointestinal symptoms. Erythematous duodenal and esophageal mucosa on endoscopy, and histopathology suggestive of reflux esophagitis were more common in the diabetes group. Diabetic children with positive celiac serology had different histopathological features as compared with their non-diabetic counterparts.
Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pornthep
P
Tanpowpong
Departments of Pediatrics, Boston University, Boston, Massachusetts, USA.
Sarabeth
S
Broder-Fingert
Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.
Aubrey J
AJ
Katz
Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Carlos A
CA
Camargo
D000293:Adolescent; D001706:Biopsy; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D005773:Gastroscopy; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D008297:Male; D012189:Retrospective Studies
child; enteropathy; esophagitis; gluten; reflux