Different applications of virus-like particles in biology and medicine: Vaccination and delivery systems.
Virus-like particles (VLPs) mimic the whole construct of virus particles devoid of viral genome as used in subunit vaccine design. VLPs can elicit efficient protective immunity as direct immunogens compared to soluble antigens co-administered with adjuvants in several booster injections. Up to now, several prokaryotic and eukaryotic systems such as insect, yeast, plant, and E. coli were used to express recombinant proteins, especially for VLP production. Recent studies are also generating VLPs in plants using different transient expression vectors for edible vaccines. VLPs and viral particles have been applied for different functions such as gene therapy, vaccination, nanotechnology, and diagnostics. Herein, we describe VLP production in different systems as well as its applications in biology and medicine.
Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.|Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Zeinab
Z
Shirbaghaee
Azam
A
Bolhassani
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D004926:Escherichia coli / Q000235:genetics; D007313:Insecta / Q000235:genetics; D010944:Plants / Q000235:genetics; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000235:genetics; D014771:Virion / Q000276:immunology; D015003:Yeasts / Q000235:genetics
D000276:Adjuvants, Immunologic; D014614:Vaccines, Synthetic
clinical trials; delivery system; prokaryotic and eukaryotic systems; vaccination; virus-like particles