Increased Causal Connectivity Related to Anatomical Alterations as Potential Endophenotypes for Schizophrenia.
Anatomical and functional abnormalities in the cortico-cerebellar-thalamo-cortical circuit have been observed in schizophrenia patients and their unaffected siblings. However, it remains unclear to the relationship between anatomical and functional abnormalities within this circuit in schizophrenia patients and their unaffected siblings, which may serve as potential endophenotypes for schizophrenia.Anatomical and resting-state functional magnetic resonance imaging data were acquired from 49 first-episode, drug-naive schizophrenia patients, 46 unaffected siblings, and 46 healthy controls. Data were analyzed by using voxel-based morphometry and Granger causality analysis.The patients and the siblings shared anatomical deficits in the left middle temporal gyrus (MTG) and increased left MTG-left angular gyrus (AG) connectivity. Moreover, the left MTG-left AG connectivity negatively correlates to the duration of untreated psychosis in the patients.The findings indicate that anatomical deficits in the left MTG and its increased causal connectivity with the left AG may serve as potential endophenotypes for schizophrenia with clinical implications.
From the Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan (GW, ZJ); Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan (LF); and Mental Health Center, The First Affiliated Hospital, Guangxi Medical University; Nanning, Guangxi, China (XC, YM, ZZ, LJ, ZJ).
Wenbin
W
Guo
Feng
F
Liu
Changqing
C
Xiao
Miaoyu
M
Yu
Zhikun
Z
Zhang
Jianrong
J
Liu
Jian
J
Zhang
Jingping
J
Zhao
D001921:Brain / Q000002:abnormalities*; D058068:Endophenotypes; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult