The role of Fc receptors in HIV prevention and therapy.
Over the past decade, a wealth of experimental evidence has accumulated supporting the importance of Fc receptor (FcR) ligation in antibody-mediated pathology and protection in many disease states. Here we present the diverse evidence base that has accumulated as to the importance of antibody effector functions in the setting of HIV prevention and therapy, including clinical correlates, genetic associations, viral evasion strategies, and a rapidly growing number of compelling animal model experiments. Collectively, this work identifies antibody interactions with FcR as important to both therapeutic and prophylactic strategies involving both passive and active immunity. These findings mirror those in other fields as investigators continue to work toward identifying the right antibodies and the right effectors to be present at the right sites at the right time.
Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Austin W
AW
Boesch
Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Eric P
EP
Brown
Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.|Molecular and Cellular Biology Program, Dartmouth College, Hanover, NH, USA.|Department of Microbiology and Immunology, Geisel School of Medicine, Lebanon, NH, USA.
Margaret E
ME
Ackerman
D016915:AIDS Vaccines / Q000276:immunology; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology; D004195:Disease Models, Animal; D014644:Genetic Variation; D015483:HIV Antibodies / Q000276:immunology* / Q000378:metabolism*; D015658:HIV Infections / Q000378:metabolism* / Q000517:prevention & control* / Q000628:therapy* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D057131:Immune Evasion; D007116:Immunization, Passive; D007070:Immunoglobulin A / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding; D011961:Receptors, Fc / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D016915:AIDS Vaccines; D015483:HIV Antibodies; D007070:Immunoglobulin A; D011961:Receptors, Fc
Fc receptor; HIV; IgA; IgG; antibody; effector function