The Vascular Endothelium in Chronic Kidney Disease: A Novel Target for Aerobic Exercise.
Endothelial dysfunction occurs in chronic kidney disease (CKD) and increases the risk for cardiovascular disease. The mechanisms of endothelial dysfunction seem to evolve throughout kidney disease progression, culminating in reduced L-arginine transport and impaired nitric oxide bioavailability in advanced disease. This review examines the hypothesis that aerobic exercise may reverse endothelial dysfunction by improving endothelial cell L-arginine uptake in CKD.
1Department of Integrative Physiology, University of Colorado, Boulder, CO; and 2Department of Kinesiology and Applied Physiology, University of Delaware, Newark, DE.
Christopher R
CR
Martens
Danielle L
DL
Kirkman
David G
DG
Edwards
D001120:Arginine / Q000031:analogs & derivatives / Q000378:metabolism; D001682:Biological Availability; D001692:Biological Transport; D002318:Cardiovascular Diseases / Q000209:etiology; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D051436:Renal Insufficiency, Chronic / Q000378:metabolism / Q000503:physiopathology*; D012307:Risk Factors
C487735:dimethylarginine; D009569:Nitric Oxide; D001120:Arginine