Acute onset anterior uveitis after darbepoetin alfa infusion.
A 79-year-old female with a 2-month history of newly diagnosed myelodysplastic syndrome for which she received blood transfusion with darbepoetin alfa presented with bilateral anterior uveitis 1 day after her fourth transfusion. On exam, visual acuity was 20/20 in both eyes with biomicroscopy notable for conjunctival injection and anterior chamber cell and flare consistent with anterior uveitis. She had no systemic symptoms, no history of eye trauma, and no known infections. This case, along with prior reports in the literature, suggests that anterior uveitis may be an idiosyncratic complication of darbepoetin alfa therapy.
Department of Ophthalmology, Scheie Eye Institute, 51 N 39th St, Philadelphia, PA, 19104, USA. jonli@mail.med.upenn.edu.
Jonathan
J
Li
Department of Ophthalmology, Scheie Eye Institute, 51 N 39th St, Philadelphia, PA, 19104, USA. stephen.orlin@uphs.upenn.edu.
Stephen E
SE
Orlin
Department of Ophthalmology, Scheie Eye Institute, 51 N 39th St, Philadelphia, PA, 19104, USA. krevere@mail.med.upenn.edu.
Karen E
KE
Revere
Department of Ophthalmology, Scheie Eye Institute, 51 N 39th St, Philadelphia, PA, 19104, USA. john.kempen@uphs.upenn.edu.|Department of Biostatistics and Epidemiology, Philadelphia, PA, USA. john.kempen@uphs.upenn.edu.|Center for Clinical Epidemiology and Biostatistics, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. john.kempen@uphs.upenn.edu.
John H
JH
Kempen
Anterior uveitis; Darbepoetin; Erythropoietin; Iritis