Carotid Anatomy Does Not Predict the Risk of New Ischaemic Brain Lesions on Diffusion-Weighted Imaging after Carotid Artery Stenting in the ICSS-MRI Substudy.
BACKGROUND
The International Carotid Stenting Study (ICSS, ISRCTN25337470) randomized patients with recently symptomatic carotid artery stenosis > 50% to carotid artery stenting (CAS) or endarterectomy. CAS increased the risk of new brain lesions visible on diffusion-weighted magnetic resonance imaging (DWI-MRI) more than endarterectomy in the ICSS-MRI Substudy. The predictors of new post-stenting DWI lesions were assessed in these patients.


METHODS
ICSS-MRI Substudy patients allocated to CAS were studied. Baseline or pre-stenting catheter angiograms were rated to determine carotid anatomy. Baseline patient demographics and the influence of plaque length, plaque morphology, internal carotid angulation, and external or common carotid atheroma were examined in negative binomial regression models.


RESULTS
A total of 115 patients (70% male, average age 70.4) were included; 50.4% had at least one new DWI-MRI-positive lesion following CAS. Independent risk factors increasing the number of new lesions were a left-sided stenosis (incidence risk ratio [IRR] 1.59, 95% CI 1.04-2.44, p = .03), age (IRR 2.10 per 10-year increase in age, 95% CI 1.61-2.74, p < .01), male sex (IRR 2.83, 95% CI 1.72-4.67, p < .01), hypertension (IRR 2.04, 95% CI 1.25-3.33, p < .01) and absence of cardiac failure (IRR 6.58, 95% CI 1.23-35.07, p = .03). None of the carotid anatomical features significantly influenced the number of post-procedure lesions.


CONCLUSIONS
Carotid anatomy seen on pre-stenting catheter angiography did not predict of the number of ischaemic brain lesions following CAS.
Institute of Neurology, University College London, UK.
D
D
Doig
University College London Medical School, UK.
B M
BM
Hobson
University of Basel, Basel, Switzerland.
M
M
Müller
Institute of Neurology, University College London, UK.
H R
HR
Jäger
Institute of Neurology, University College London, UK.
R L
RL
Featherstone
Institute of Neurology, University College London, UK. Electronic address: martin.brown@ucl.ac.uk.
M M
MM
Brown
Institute of Neurology, University College London, UK; Department of Neurology and Stroke Unit, University Hospital Basel, Basel, Switzerland.
L H
LH
Bonati
Division of Surgery and Interventional Science, University College London, UK.
T
T
Richards
D000367:Age Factors; D000368:Aged; D017130:Angioplasty / Q000009:adverse effects* / Q000295:instrumentation*; D002545:Brain Ischemia / Q000175:diagnosis* / Q000209:etiology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D016893:Carotid Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D015897:Comorbidity; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011859:Radiography; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D015607:Stents; D016896:Treatment Outcome
Brain ischaemia; Carotid artery stenosis; Carotid artery ulcerating plaque; Carotid atherosclerosis; Stents