Structural and magnetic properties of cobalt-doped iron oxide nanoparticles prepared by solution combustion method for biomedical applications.
Cobalt-doped iron oxide nanoparticles were prepared by solution combustion technique. The structural and magnetic properties of the prepared samples were also investigated. The average crystallite size of cobalt ferrite (CoFe2O4) magnetic nanoparticle was calculated using Scherrer equation, and it was found to be 16±5 nm. The particle size was measured by transmission electron microscope. This value was found to match with the crystallite size calculated by Scherrer equation corresponding to the prominent intensity peak (311) of X-ray diffraction. The high-resolution transmission electron microscope image shows clear lattice fringes and high crystallinity of cobalt ferrite magnetic nanoparticles. The synthesized magnetic nanoparticles exhibited the saturation magnetization value of 47 emu/g and coercivity of 947 Oe. The anti-microbial activity of cobalt ferrite nanoparticles showed better results as an anti-bacterial agent. The affinity constant was determined for the nanoparticles, and the cytotoxicity studies were conducted for the cobalt ferrite nanoparticles at different concentrations and the results are discussed.
School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, India.
Kaliyamoorthy
K
Venkatesan
School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, India.
Dhanakotti
D
Rajan Babu
School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India.
Mane Prabhu
MP
Kavya Bai
School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India.
Ravi
R
Supriya
School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India.
Radhakrishnan
R
Vidya
School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, India.
Saminathan
S
Madeswaran
Research Institute of Electronics, Shizuoka University, Hamamatsu, Japan.
Pandurangan
P
Anandan
Research Institute of Electronics, Shizuoka University, Hamamatsu, Japan.
Mukannan
M
Arivanandhan
Research Institute of Electronics, Shizuoka University, Hamamatsu, Japan.
Yasuhiro
Y
Hayakawa
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D003035:Cobalt / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012996:Solutions; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D005290:Ferric Compounds; D012996:Solutions; C001215:ferrite; C000499:ferric oxide; D003035:Cobalt
HR-TEM; VSM; cytotoxicity; magnetic nanoparticles