Anti-rheumatoid arthritic effects of Saussurea involucrata on type II collagen-induced arthritis in rats.
Saussurea involucrata (SI) has long been used under the herbal name "snow lotus" for treatment of inflammation and pain-related diseases in traditional Chinese medicine. The present study aimed to evaluate the pharmacological effects of SI on collagen II (CII)-induced arthritis in rats. Rats with collagen II (CII)-induced arthritis were orally administered SI (420 mg kg(-1)) for 40 consecutive days. Histopathological examination indicated that SI alleviates infiltration of inflammatory cells and synovial hyperplasia and slows joint destruction. SI intervention reduced the serum levels of RF, COMP, CRP and anti-CII IgG. Results also showed that SI is a potential therapeutic agent for alleviating the severity of the disease based on the reduced arthritic index. It was concluded that SI can ameliorate inflammation and joint destruction in CIA rats.
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China. bmuwjbxy@bjmu.edu.cn and Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing, PR China.
Meihong
M
Xu
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China. bmuwjbxy@bjmu.edu.cn and Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing, PR China.
Qianying
Q
Guo
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China. bmuwjbxy@bjmu.edu.cn and Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing, PR China.
Shuangjia
S
Wang
R&D Center of TIENS Ltd, Tianjin, PR China.
Na
N
Wang
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China. bmuwjbxy@bjmu.edu.cn and Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing, PR China.
Liren
L
Wei
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China. bmuwjbxy@bjmu.edu.cn and Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing, PR China.
Junbo
J
Wang
D000818:Animals; D018501:Antirheumatic Agents / Q000008:administration & dosage*; D001169:Arthritis, Experimental; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D002097:C-Reactive Protein / Q000276:immunology; D024043:Collagen Type II / Q000009:adverse effects* / Q000276:immunology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D030441:Saussurea / Q000737:chemistry*
D018501:Antirheumatic Agents; D024043:Collagen Type II; D004365:Drugs, Chinese Herbal; D002097:C-Reactive Protein