Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases.
Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro- and anti-inflammatory mediators in the liver. These mediators are the driving force of many inflammatory liver disorders, which often result in fibrosis, cirrhosis, and liver tumorigenesis. c-Myc is involved in many cellular events such as cell growth, proliferation, and differentiation. c-Myc upregulates IL-8, IL-10, TNF-α, and TGF-β, while IL-1, IL-2, IL-4, TNF-α, and TGF-β promote c-Myc expression. Their interactions play a central role in fibrosis, cirrhosis, and liver cancer. Molecular interference of their interactions offers possible therapeutic potential for CLDs. In this review, current knowledge of the molecular interactions between c-Myc and various well known inflammatory mediators is discussed.
Department of Gastroenterology, Xiangya Hospital Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
Ting
T
Liu
GI Liver Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Yu
Y
Zhou
Department of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul 150-750, Republic of Korea.
Kwang Suk
KS
Ko
Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Davis Building 2094A, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Heping
H
Yang
D000818:Animals; D063646:Carcinogenesis; D002454:Cell Differentiation; D049109:Cell Proliferation; D002908:Chronic Disease; D005355:Fibrosis / Q000473:pathology; D006519:Hepatitis, Alcoholic / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism; D008099:Liver / Q000293:injuries; D008103:Liver Cirrhosis / Q000473:pathology; D008107:Liver Diseases / Q000276:immunology / Q000628:therapy*; D008113:Liver Neoplasms / Q000473:pathology; D051379:Mice; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D018808:Transcription Factor AP-1 / Q000378:metabolism
D007378:Interleukins; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D018808:Transcription Factor AP-1