Reversible improvement in severe freezing of gait from Parkinson's disease with unilateral interleaved subthalamic brain stimulation.
Freezing of gait causes considerable morbidity in patients with Parkinson's disease and is often refractory to conventional treatments. In this double-blind, randomized evaluation, unilateral interleaved deep brain stimulation in the subthalamic nucleus/substantia nigra pars reticulata region significantly improved freezing of gait in a patient with advanced Parkinson's disease.
Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL 35294-0017, USA.
Stephanie N
SN
Brosius
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294-0017, USA.
Christopher L
CL
Gonzalez
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294-0017, USA.
Joshita
J
Shuresh
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294-0017, USA; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294-0017, USA. Electronic address: hcwalker@uab.edu.
Harrison C
HC
Walker
D046690:Deep Brain Stimulation / Q000379:methods*; D004311:Double-Blind Method; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D013378:Substantia Nigra / Q000503:physiopathology*; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D014743:Videotape Recording
Freezing of gait; Interleaved deep brain stimulation; Parkinson's disease; Substantia nigra pars reticulata; Subthalamic nucleus