Correlation of serum uric acid with heart rate variability in hypertension.
BACKGROUND
Autonomic dysfunction with dominant sympathetic tone is a common finding among hypertensives and prehypertensives. Uric acid is one of the independent predictors of hypertension. There are very few studies which have shown a relationship between the autonomic tone and uric acid generation pathway among prehypertensives and hypertensives. Aim of the study was to estimate and correlate serum uric acid levels with autonomic function as measured by heart rate variability (HRV) among prehypertensives and hypertensives.


METHODS
Cross-sectional study of three groups, prehypertensives, hypertensives and normotensives, classified according to Joint National Committee VII criteria, with 35 subjects in each group were included in this study. Serum uric acid levels were estimated by using colorimetric assay kit. HRV was analyzed after recording lead II Electrocardiogram using RMS Vagus HRV software (RMS, India). One-way ANOVA and Pearson's correlation was done using SPSS 18.0 software.


RESULTS
Mean uric acid levels were 5.62±2.21mg/dL in normal subjects, 7.06±2.87mg/dL in prehypertensives and 9.77±2.04mg/dL in hypertensives. There was statistically significant negative correlation between uric acid and time domain parameters of HRV in the whole sample and among prehypertensives and positive correlation with low frequency power (LF) in ms(2) and n.u.


CONCLUSIONS
Serum uric acid levels were high in prehypertensives and hypertensives as compared to normal subjects. Further, there was statistically significant correlation seen between uric acid levels and sympathetic domain parameters particularly among prehypertensives.
Department of Physiology, M. S. Ramaiah Medical College, Bengaluru, Karnataka 560072, India. Electronic address: kirthanaku@gmail.com.
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Kunikullaya
Department of Physiology, M. S. Ramaiah Medical College, Bengaluru, Karnataka 560072, India. Electronic address: navya.purushotham@gmail.com.
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Purushottam
Department of Physiology, M. S. Ramaiah Medical College, Bengaluru, Karnataka 560072, India. Electronic address: vaishnavi_prakash@yahoo.co.in.
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Prakash
Department of Physiology, M. S. Ramaiah Medical College, Bengaluru, Karnataka 560072, India. Electronic address: sushma.4493@gmail.com.
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Mohan
Department of Physiology, M. S. Ramaiah Medical College, Bengaluru, Karnataka 560072, India. Electronic address: ramyasee@yahoo.com.
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Chinnaswamy
D001341:Autonomic Nervous System; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D006339:Heart Rate; D006801:Humans; D006973:Hypertension; D058246:Prehypertension; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid
Heart rate variability; Hipertensión; Hypertension; Prehipertensión; Prehypertension; Uric acid; Variabilidad de la frecuencia cardíaca; Ácido úrico