Aβ1-40 and Aβ1-42 Plasmatic Levels In Stroke: Influence of Pre-Existing Cognitive Status and Stroke Characteristics.
Many stroke patients have pre-existing cognitive impairment. Plasma amyloid β peptides (Aβ) - possible biomarkers of Alzheimer's pathology - induce vascular dysfunction. Our objective was to evaluate factors influencing plasma Aβ1-40 and Aβ1-42 peptides in a cohort of stroke patients. In the Biostroke study (ClinicalTrials.gov Identifier: NCT00763217), we collected vascular risk factors, neuroimaging features and biological tests including Aβ1-40 and Aβ1-42. We used the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) to systematically assess the pre-existing cognitive status. Of 403 patients (371 ischemia), 25 met criteria for pre-existing dementia, 142 for pre-existing cognitive decline-no-dementia, and 236 had no PCoI. Aβ1-42 was independently associated with PCoI (odds ratio 0.973; 95% confidence interval: 0.950-0.996; p=0.024). Factors associated with plasma Aβ1- 40 were age, smoking and diabetes mellitus. After exclusion of hemorrhagic strokes, the results remained unchanged, but blood samples taken less than 12 hours after onset were associated with lower plasma Aβ1-40. Our results support a dissociated response of the 2 plasma Aβ peptides in stroke patients, plasma Aβ1-40 being involved in vascular aspects whereas Aβ1-42 might be involved in neurodegenerative processes.
Department of Neurology, Stroke Unit, Roger Salengro Hospital, Rue Emile Laine, F-59037 Lille, France.
Solene
S
Moulin
Department of Neurology, Stroke Unit, Roger Salengro Hospital, Rue Emile Laine, F-59037 Lille, France.
Didier
D
Leys
Susanna
S
Schraen-Maschke
Department of Neurology, Stroke Unit, Roger Salengro Hospital, Rue Emile Laine, F-59037 Lille, France.
Stephanie
S
Bombois
Anne-Marie
AM
Mendyk
Anne
A
Muhr-Tailleux
Department of Neurology, Stroke Unit, Roger Salengro Hospital, Rue Emile Laine, F-59037 Lille, France.
Charlotte
C
Cordonnier
Luc
L
Buee
Department of Neurology, Stroke Unit, Roger Salengro Hospital, Rue Emile Laine, F-59037 Lille, France.
Florence
F
Pasquier
Department of Neurology, Stroke Unit, Roger Salengro Hospital, Rue Emile Laine, F-59037 Lille, France.
Regis
R
Bordet
D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000097:blood*; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000097:blood*; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood* / Q000150:complications*
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)
Stroke; cerebral hemorrhage; cerebral infarction; cerebral ischemia; cognitive decline; cohort studies; dementia; plasma amyloid
beta peptides