Gasdermin D: the long-awaited executioner of pyroptosis.
Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.
Department of Immunology, St. Jude Children's Research Hospital, MS #351, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Si Ming
SM
Man
Department of Immunology, St. Jude Children's Research Hospital, MS #351, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Thirumala-Devi
TD
Kanneganti
D000818:Animals; D020169:Caspases / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D028044:Phosphate-Binding Proteins; D000069292:Pyroptosis; D000094524:Gasdermins
D020169:Caspases; D047908:Intracellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides; D009363:Neoplasm Proteins; D028044:Phosphate-Binding Proteins; C498366:GSDMD protein, human; D000094524:Gasdermins; C413482:Gsdma protein, mouse