Preparation of highly stable fullerene C60 decorated graphene oxide nanocomposite and its sensitive electrochemical detection of dopamine in rat brain and pharmaceutical samples.
The research community has continuously paid much attention on the preparation of hybrid of carbon nanomaterials owing to combine their unique properties. Herein, we report the preparation of highly stable fullerene C60 (C60) wrapped graphene oxide (GO) nanocomposite by using a simple sonication method. The fabricated GO-C60 nanocomposite modified glassy carbon electrode shows a good sensitivity and lower oxidation overpotential towards dopamine (DA) than that of pristine GO and C60. The fabricated sensor detects the DA in the linear response range of 0.02-73.5μM. The limit of detection is estimated to be 0.008μM based on 3σ with a sensitivity of 4.23μAμM(-1)cm(-2). The fabricated sensor also exhibits other features such as good selectivity, stability, reproducibility and repeatability. The proposed sensor exhibits good practicality towards the detection of DA in rat brain and commercial DA injection samples.
Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan.
Balamurugan
B
Thirumalraj
Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan.
Selvakumar
S
Palanisamy
Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan. Electronic address: smchen78@ms15.hinet.net.
Shen-Ming
SM
Chen
Chemistry Division, Center for General Education, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan. Electronic address: blou@mail.cgu.edu.tw.
Bih-Show
BS
Lou
D000818:Animals; D001923:Brain Chemistry; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques; D004566:Electrodes; D037741:Fullerenes / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D051381:Rats; D013499:Surface Properties
D037741:Fullerenes; D010087:Oxides; D004364:Pharmaceutical Preparations; D006108:Graphite; C069837:fullerene C60; D004298:Dopamine
Differential pulse voltammetry; Dopamine; Electrochemical sensor; Fullerene C60; Graphene oxide; Nanocomposite