Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication: A prospective single-center study from China.
OBJECTIVE
To investigate the effects of daily telephone-based re-education (TRE) before taking medicine for the eradication of Helicobacter pylori (H. pylori) on the compliance and the eradication rate in a Chinese patient population.


METHODS
A prospective, physician-blinded, randomized, controlled clinical study was conducted. The patients were randomly assigned to receive TRE every day before taking medicine (TRE group) or no TRE (control group). The patients in the TRE group received regular instructions before taking medicine for the eradication of H. pylori during the entire course of treatment through telephone calls. The patients in the control group received detailed instructions at the time of seeing a doctor for the guidance. The primary outcome was the H. pylori eradication rate after treatment. The secondary outcomes included the clinical remissions after treatment, adverse events, compliance, and patients' satisfaction.


RESULTS
A total of 140 patients were randomized, 70 to the TRE group and 70 to the control group. As the primary outcome, the H. pylori eradication rates in the TRE and control groups were 62.7% and 71.2% in per protocol analysis (P = 0.230), and 52.9% and 52.9% in intention-to-treat analysis (P = 0.567), respectively. As the secondary outcomes, there were no significant differences in the patients' satisfaction between the two groups (good, 79.7% vs 76.9%; fair, 13.6% vs 19.2%; poor, 6.7% vs 3.9%, for the TRE group and control group, respectively; P > 0.05 for all); the rates of adverse effects were 15.2% and 63.5% in the TRE and control groups, respectively (P < 0.001); the compliance rates in the TRE and control groups were 85.7% and 74.3%, respectively (P = 0.069).


CONCLUSIONS
Daily TRE before taking medicine had no significant impact on the patients' compliance, satisfaction, or H. pylori eradication, but reduced the rate of adverse events.
Chun-Hua Wang, Jun Yang, Chun-Xia Li, Ying-Ying Yang, Dong-Feng Chen, Chun-Hui Lan, Department of Gastroenterology, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Chun-Hua
CH
Wang
Chun-Hua Wang, Jun Yang, Chun-Xia Li, Ying-Ying Yang, Dong-Feng Chen, Chun-Hui Lan, Department of Gastroenterology, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Sheng-Tao
ST
Liao
Chun-Hua Wang, Jun Yang, Chun-Xia Li, Ying-Ying Yang, Dong-Feng Chen, Chun-Hui Lan, Department of Gastroenterology, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Jun
J
Yang
Chun-Hua Wang, Jun Yang, Chun-Xia Li, Ying-Ying Yang, Dong-Feng Chen, Chun-Hui Lan, Department of Gastroenterology, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Chun-Xia
CX
Li
Chun-Hua Wang, Jun Yang, Chun-Xia Li, Ying-Ying Yang, Dong-Feng Chen, Chun-Hui Lan, Department of Gastroenterology, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Ying-Ying
YY
Yang
Chun-Hua Wang, Jun Yang, Chun-Xia Li, Ying-Ying Yang, Dong-Feng Chen, Chun-Hui Lan, Department of Gastroenterology, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Ran
R
Han
Chun-Hua Wang, Jun Yang, Chun-Xia Li, Ying-Ying Yang, Dong-Feng Chen, Chun-Hui Lan, Department of Gastroenterology, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Dong-Feng
DF
Chen
Chun-Hua Wang, Jun Yang, Chun-Xia Li, Ying-Ying Yang, Dong-Feng Chen, Chun-Hui Lan, Department of Gastroenterology, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Chun-Hui
CH
Lan
D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002681:China; D017291:Clarithromycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D064098:Esomeprazole / Q000627:therapeutic use; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D057194:Intention to Treat Analysis; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010353:Patient Education as Topic / Q000379:methods*; D017060:Patient Satisfaction; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D012074:Remission Induction; D013689:Telephone; D013997:Time Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D000658:Amoxicillin; D017291:Clarithromycin; D064098:Esomeprazole
Adverse events; Compliance; Eradication; Helicobacter pylori; Telephone re-education