Monosodium glutamate-induced oxidative kidney damage and possible mechanisms: a mini-review.
Animal studies suggest that chronic monosodium glutamate (MSG) intake induces kidney damage by oxidative stress. However, the underlying mechanisms are still unclear, despite the growing evidence and consensus that α-ketoglutarate dehydrogenase, glutamate receptors and cystine-glutamate antiporter play an important role in up-regulation of oxidative stress in MSG-induced renal toxicity. This review summaries evidence from studies into MSG-induced renal oxidative damage, possible mechanisms and their importance from a toxicological viewpoint.
Department of Physiology, Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand. amod.sha@mahidol.ac.th.|Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. amod.sha@mahidol.ac.th.
Amod
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Sharma
D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D012970:Sodium Glutamate / Q000009:adverse effects*
D012970:Sodium Glutamate