Core-shell of FePt@SiO2-Au magnetic nanoparticles for rapid SERS detection.
In this study, multifunctional hybrid nanoparticles composed of iron platinum (FePt), silica (SiO2), and gold nanoparticles (AuNPs) had been developed for surface-enhanced Raman scattering (SERS) application. Core-shell structure of SiO2 and FePt nanoparticles (FePt@SiO2) was fabricated through sol-gel process and then immobilized gold nanoparticles onto the surface of FePt@SiO2, which displays huge Raman enhancement effect and magnetic separation capability. The resulting core-shell nanoparticles were subject to evaluation by transmission electron microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDX), zeta potential measurement, and X-ray photoelectron spectroscopy (XPS). TEM observation revealed that the particle size of resultant nanoparticles displayed spherical structure with the size ~30 nm and further proved the successful immobilization of Au onto the surface of FePt@SiO2. Zeta potential measurement exhibited the successful reaction between FePt@SiO2 and AuNPs. The rapid SERS detection and identification of small biomolecules (adenine) and microorganisms (gram-positive bacteria, Staphylococcus aureus) was conducted through Raman spectroscopy. In summary, the novel core-shell magnetic nanoparticles could be anticipated to apply in the rapid magnetic separation under the external magnetic field due to the core of the FePt superparamagnetic nanoparticles and label-free SERS bio-sensing of biomolecules and bacteria.
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan. d10004810@mail.ntust.edu.tw.
Andri
A
Hardiansyah
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan. naruto800203@hotmail.com.
An-Yu
AY
Chen
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan. firstoneayu@hotmail.com.
Hung-Liang
HL
Liao
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan. myang@mail.ntust.edu.tw.
Ming-Chien
MC
Yang
Department of Materials Engineering, Ming Chi University of Technology, New Taipei City, 24301, Taiwan. tyliu0322@gmail.com.
Ting-Yu
TY
Liu
Department of Materials Engineering, Ming Chi University of Technology, New Taipei City, 24301, Taiwan. u01187039@mail2.mcut.edu.tw.
Tzu-Yi
TY
Chan
Department of Materials Engineering, Ming Chi University of Technology, New Taipei City, 24301, Taiwan. u01187135@mail2.mcut.edu.tw.
Hui-Ming
HM
Tsou
Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 10617, Taiwan. F99549022@ntu.edu.tw.
Chih-Yu
CY
Kuo
Center for Condensed Matter Sciences, National Taiwan University, Taipei, 10617, Taiwan. jkwang@ntu.edu.tw.|Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 10617, Taiwan. jkwang@ntu.edu.tw.
Juen-Kai
JK
Wang
Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, 10617, Taiwan. ylwang@pub.iams.sinica.edu.tw.|Department of Physics, National Taiwan University, Taipei, 10617, Taiwan. ylwang@pub.iams.sinica.edu.tw.
Yuh-Lin
YL
Wang
Bio-detection; Core-shell nanoparticles; Magnetic separation; Surface-enhanced Raman scattering