The effect of histamine on changes in mental energy and fatigue after a single bout of exercise.
The purpose of this research was to determine if histamine, acting on brain H1 receptors, influences changes in feelings of energy and fatigue or cognitive test performance after acute exercise. Women (n=20) with low vigor and high fatigue were administered the H1 antagonist drug doxepin hydrocholoride (6 mg) in tomato juice and tomato juice alone (placebo) in a randomized, double-blinded, cross-over experiment before performing 30 min of light intensity cycling exercise and completing energy, fatigue, sleepiness, and motivation scales, and cognitive tasks. After exercise, mental fatigue increased for the doxepin condition (p=0.014) but not placebo (p=0.700), while mental energy decreased for both PLA and DOX (p<0.001) and cognitive task performance was unaffected. It is inferred that histamine binding to H1 receptors in the brain has a role in exercise-induced reductions in mental fatigue, but not increases in energy.
Department of Kinesiology, University of Georgia, Athens, Georgia. Electronic address: bloy@uga.edu.
Bryan D
BD
Loy
Department of Kinesiology, University of Georgia, Athens, Georgia.
Patrick J
PJ
O'Connor
D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004311:Double-Blind Method; D004316:Doxepin / Q000494:pharmacology; D015444:Exercise / Q000502:physiology*; D005221:Fatigue / Q000503:physiopathology*; D005260:Female; D005425:Flicker Fusion / Q000502:physiology; D006632:Histamine / Q000502:physiology*; D006633:Histamine Antagonists / Q000494:pharmacology; D006801:Humans; D009042:Motivation / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects; D055815:Young Adult
D006633:Histamine Antagonists; D004316:Doxepin; D006632:Histamine
Attention; Cognition; Doxepin; Motivation; Sleep; Vigor