C-N Coupling of Amides with Alcohols Catalyzed by N-Heterocyclic Carbene-Phosphine Iridium Complexes.
N-Heterocyclic carbene-phosphine iridium complexes (NHC-Ir) were developed/found to be a highly reactive catalyst for N-monoalkylation of amides with alcohols via hydrogen transfer. The reaction produced the desired product in high isolated yields using a wide range of substrates with low catalyst loading and short reaction times.
Department of Organic Chemistry, Stockholm University , S-10691, Stockholm, Sweden.
Sutthichat
S
Kerdphon
Department of Organic Chemistry, Stockholm University , S-10691, Stockholm, Sweden.
Xu
X
Quan
Department of Chemistry, S. P. Pune University , Pune 411007, India.
Vijay Singh
VS
Parihar
Department of Organic Chemistry, Stockholm University , S-10691, Stockholm, Sweden.
Pher G
PG
Andersson