Saphenous Vein Graft Disease Is Associated with a Low Serum Erythropoietin Level.
OBJECTIVE
To measure the serum erythropoietin (EPO) level in patients with saphenous vein grafts (SVGs) and to compare the EPO level in those with and without SVG disease.


METHODS
The study included 85 consecutive patients with a history of coronary artery bypass graft surgery that underwent elective coronary angiography. Patients with >30% stenosis (diseased grafts) in at least one saphenous graft were included in group 1 (diseased group: n = 40), and group 2 (nondiseased group: n = 45) consisted of patients without diseased SVGs. The EPO level was measured using enzyme-linked immunosorbent assay (ELISA) using a commercially available ELISA kit; x03C7;2 test and independent samples t test were used where appropriate. Logistic regression was used for multivariate analysis.


RESULTS
There were not any significant differences in age, gender, or cardiovascular risk factors between the two groups except for increased triglyceride and low high-density lipoprotein levels in group 2. The EPO level was significantly higher in the nondiseased SVG group than in the diseased SVG group (25.5 ± 9.6 vs. 17.8 ± 6.8 mU ml-1, p = 0.002). Multivariate logistic regression analysis showed that the serum EPO level was an independent predictor of SVG disease (OR 1.14, 95% CI 1.06-1.24, p = 0.001).


CONCLUSIONS
In this study, SVG disease was associated with a low serum EPO level, suggesting that a low EPO level could be predictive of and contributes to the pathophysiology of SVG disease.
Department of Cardiology at Aydx0131;n State Hospital, Aydx0131;n, Turkey.
İbrahim
İ
Kocaoğlu
Uğur
U
Arslan
Yavuzer
Y
Koza
Mustafa Mücahit
MM
Balcı
Gizem
G
Çelik
Sinan
S
Aydoğdu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003251:Constriction, Pathologic / Q000503:physiopathology*; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012501:Saphenous Vein / Q000503:physiopathology*
D004921:Erythropoietin