Perceived age is associated with bone status in women aged 25-93 years.
Higher perceived age (PA) is reported to be associated with age-related diseases. Because osteoporosis is considered an age-related disease, we hypothesized that age perceived from photographs is associated with bone mineral density (BMD)/trabecular bone score (TBS) when controlled for chronological age. This is a cross-sectional study of 460 women aged 25-93 years. BMD/TBS was measured. Twenty physicians assessed age from facial and whole-body photographs. Residual PA (R(PACA)) was calculated from the regression of PA on chronological age. Participants were divided into "looking old" (LO) or "looking young" (LY). Linear mixed models and general linear models fitted with BMD/TBS as outcome and either R(PACA) or LO/LY as an independent variable, considering chronological age. Estimates of R(PACA) were all negative; i.e., an increase in R(PAC) is associated with lower BMD, consistent with the hypothesis (e.g., β -0.29%; 95% confidence interval (CI) 0.55, 0.03). Statistical significance of the association of age-adjusted facial R(PACA) with BMD was found. Adjusted for body mass index (BMI), menopause, and hormone replacement therapy, higher R(PACA) from all photographic presentations were significantly associated with lower BMD based on statistical significance. BMD/TBS was in all analyses higher in the group LY compared with LO, when adjusted for age and BMI (e.g., β 4.37%; 95 CI 0.62, 8.26), but statistical significance was obtained only from the BMD analyses. A higher PA was significantly associated with a lower BMD/TBD, and the size of association in older women indicates that it might have value as part of the clinical assessment of osteoporotic risk.
Research Centre of Ageing and Osteoporosis, Departments of Endocrinology PE and Clinical Biochemistry, Rigshospitalet, Blegdamsvej and Glostrup, Copenhagen, Denmark. Barbara.rubek.nielsen@regionh.dk.|Department of Medicine, Geriatrics, Amager and Hvidovre Hospital Glostrup, Ndr. Ringvej 69 (North), 2600, Glostrup, Denmark. Barbara.rubek.nielsen@regionh.dk.
Barbara Rubek
BR
Nielsen
Research Centre for Prevention and Health, the Capital Region of Denmark, Copenhagen, Denmark.|Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.|Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Allan
A
Linneberg
Danish Research Centre of Ageing, University of Southern Denmark, Odense, Denmark.|Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.|Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Kaare
K
Christensen
Research Centre of Ageing and Osteoporosis, Departments of Endocrinology PE and Clinical Biochemistry, Rigshospitalet, Blegdamsvej and Glostrup, Copenhagen, Denmark.|Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Peter
P
Schwarz
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015519:Bone Density; D003430:Cross-Sectional Studies; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis*; D010781:Photography; D018570:Risk Assessment
Aging; Bone mineral density; Osteoporosis; Perceived age; Posture