An Arresting Story about Basement Membrane Invasion.
In this issue of Developmental Cell, Matus et al. (2015) reveal that to invade past basement membrane, the C. elegans anchor cell must cease dividing before differentiating and expressing pro-invasion genes. This demonstration of invasion and proliferation as mutually incompatible cell states has implications for our understanding of cancer metastasis.
Departments of Cell Biology, Oncology, and Biomedical Engineering, School of Medicine, Johns Hopkins University, 855 N. Wolfe Street, Rangos 452, Baltimore, MD 21205, USA. Electronic address: andrew.ewald@jhmi.edu.
Andrew J
AJ
Ewald
D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000096:biosynthesis*; D002454:Cell Differentiation / Q000235:genetics*; D059585:G1 Phase Cell Cycle Checkpoints / Q000235:genetics*; D006655:Histone Deacetylases / Q000096:biosynthesis*; D009361:Neoplasm Invasiveness / Q000235:genetics*
D029742:Caenorhabditis elegans Proteins; D006655:Histone Deacetylases