[Pregnancy and delivery with transfer of vitrified blastocysts following trophectoderm biopsy].
Application of preimplantation genetic diagnosis makes it possible to transfer only embryos unaffected by a certain genetic disorder. The authors have applied the combination of trophectoderm biopsy and vitrification in order to detect a monogenic disorder. Previously diagnosed type 1 neurofibromatosis of the woman was the indication for genetic examination. In vitro fertilisation and embryo culture was performed using sequential culture mediums. Seven blastocysts could be sampled on the fifth day and were vitrified subsequently. Two blastocysts turned out to be genetically normal based on the result of genetic examination using polimerase chain reaction. A healthy boy was delivered following the transfer of warmed blastocysts and an uneventful singleton pregnancy.
Kaáli Intézet Budapest, Istenhegyi út 54/A, 1125.
Szabolcs
S
Mátyás
Istenhegyi Géndiagnosztikai, Nőgyógyászati és Családtervezési Centrum Budapest.
Tünde
T
Varga
Kaáli Intézet Budapest, Istenhegyi út 54/A, 1125.
Péter
P
Kovács
Istenhegyi Géndiagnosztikai, Nőgyógyászati és Családtervezési Centrum Budapest.
Márton
M
Kónya
Kaáli Intézet Budapest, Istenhegyi út 54/A, 1125.
Klára
K
Rajczy
Kaáli Intézet Budapest, Istenhegyi út 54/A, 1125.
Éva
É
Babenko
Kaáli Intézet Budapest, Istenhegyi út 54/A, 1125.
Barbara
B
Szabó
Kaáli Intézet Budapest, Istenhegyi út 54/A, 1125.
G Steven
GS
Kaali
Istenhegyi Géndiagnosztikai, Nőgyógyászati és Családtervezési Centrum Budapest.
Zoltán
Z
Szentirmay
D000328:Adult; D001706:Biopsy; D001755:Blastocyst; D036861:Delivery, Obstetric; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000235:genetics; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D014327:Trophoblasts; D058989:Vitrification
embriótranszfer; in vitro fertilization; in vitro fertilizáció; láncreakció; polimeráz; polymerase chain reaction; preimplantation genetic diagnosis; preimplantációs genetikai diagnosztika; vitrification; vitrifikáció