A Survey of Attitudes towards the Clinical Application of Systemic Inflammation Based Prognostic Scores in Cancer.
BACKGROUND
The systemic inflammatory response (SIR) plays a key role in determining nutritional status and survival of patients with cancer. A number of objective scoring systems have been shown to have prognostic value; however, their application in routine clinical practice is not clear. The aim of the present survey was to examine the range of opinions internationally on the routine use of these scoring systems.


METHODS
An online survey was distributed to a target group consisting of individuals worldwide who have reported an interest in systemic inflammation in patients with cancer.


RESULTS
Of those invited by the survey (n = 238), 65% routinely measured the SIR, mainly for research and prognostication purposes and clinically for allocation of adjuvant therapy or palliative chemotherapy. 40% reported that they currently used the Glasgow Prognostic Score/modified Glasgow Prognostic Score (GPS/mGPS) and 81% reported that a measure of systemic inflammation should be incorporated into clinical guidelines, such as the definition of cachexia.


CONCLUSIONS
The majority of respondents routinely measured the SIR in patients with cancer, mainly using the GPS/mGPS for research and prognostication purposes. The majority reported that a measure of the SIR should be adopted into clinical guidelines.
Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.
David G
DG
Watt
Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.
Campbell S
CS
Roxburgh
University of Glasgow, Glasgow Medical School, University Avenue, Glasgow G12 8QQ, UK.
Mark
M
White
University of Glasgow, Glasgow Medical School, University Avenue, Glasgow G12 8QQ, UK.
Juen Zhik
JZ
Chan
Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.
Paul G
PG
Horgan
Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.
Donald C
DC
McMillan
D000970:Antineoplastic Agents / Q000737:chemistry; D001291:Attitude of Health Personnel; D002100:Cachexia / Q000150:complications / Q000473:pathology*; D015331:Cohort Studies; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007391:International Cooperation; D020407:Internet; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D010166:Palliative Care; D011379:Prognosis; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
D000970:Antineoplastic Agents