Clinical presentation of intraocular retinoblastoma; 5-year hospital-based registry in Egypt.
OBJECTIVE
To study the presenting signs of Retinoblastoma in Egypt at Egypt's main pediatric oncology referral center.


METHODS
This is a prospective descriptive study (hospital-based registry) conducted at Children's Cancer Hospital Egypt between July 2007 and December 2012.


RESULTS
Out of 262 patients diagnosed with retinoblastoma, 244 were suffering from intra-ocular disease at presentation. One hundred thirty-nine (57%) patients presented with unilateral disease, while 105 (43%) suffered bilateral disease. The mean age at presentation was 20.6 ± 17 months, averaging 18.87 ± 11.76 months for bilateral and 25.72 ± 18.78 months for unilateral disease. The most common clinical presentation was leukocoria in 180 (73.8%) patients, strabismus in 32 (13.1%) patients and decreased visual acuity in 12 (4.9%) patients. Group D and E disease represented 62% of all affected eyes. Patients with advanced disease (Group C-E) had longer duration of symptoms.


CONCLUSIONS
In Egypt, retinoblastoma patients present more frequently with advanced disease. There is an ever-increasing need to develop a national team dedicated to studying disease significance and formulating a national awareness program.
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Egyptian National Cancer Institute, Cairo University, Cairo, Egypt.
Hossam
H
El Zomor
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt.
Radwa
R
Nour
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Research Institute of Ophthalmology, Cairo, Egypt.
Adel
A
Alieldin
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Egyptian National Cancer Institute, Cairo University, Cairo, Egypt.
Hala
H
Taha
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Tanta University Medical School, Egypt.
Mohamed M
MM
Montasr
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Faculty of Medicine, Menofeyia University, Shebin Elkom, Egypt.
Emad
E
Moussa
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Beni sweif University Medical School, Beni sweif, Egypt.
Enas
E
El Nadi
National Liver Institute, Menofeyia University, Shebin Elkom, Egypt.
Sameera
S
Ezzat
Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Cairo University School of Medicine, Cairo, Egypt. Electronic address: ahmadsfar@gmail.com.
Ahmad S
AS
Alfaar
D002675:Child, Preschool; D004534:Egypt / Q000453:epidemiology; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012042:Registries; D012175:Retinoblastoma / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D047368:Tumor Burden
Developing countries; Egypt; Incidence; Retinoblastoma