Bioanalysis of ibrutinib and its active metabolite in human plasma: selectivity issue, impact assessment and resolution.
Ronald de Vries graduated in Organic and Analytical Chemistry at the Free University of Amsterdam, The Netherlands. After working in a Contract Laboratory (CRO) for 7 years, he joined Janssen R&D in 1998. At Janssen R&D, Belgium, Ronald worked in the bioanalytical department that supports both clinical and nonclinical bioanalysis. In this department he had several roles, such as providing the bioanalytical support for various drug development programs and leading the method establishment group. He has done numerous global assay transfers to/from Janssen from/to other laboratories and plays an important role in the introduction and application of new technologies and applied innovation in the department. In 2014 he started in the drug metabolism and pharmacokinetics department of Janssen R&D, where his main tasks are in vivo and in vitro metabolite identification using high resolution MS and Radiodetection.
Janssen Research & Development, Beerse, Belgium.
Ronald
R
de Vries
Janssen Research & Development, Spring House, PA, USA.
Mike
M
Huang
Janssen Research & Development, Beerse, Belgium.
Nini
N
Bode
Pharmacyclics, LLC, Sunnyvale, CA, USA.
Purvi
P
Jejurkar
Janssen Research & Development, San Diego, CA, USA.
Jan de
Jd
Jong
Pharmacyclics, LLC, Sunnyvale, CA, USA.
Juthamas
J
Sukbuntherng
Janssen Research & Development, Beerse, Belgium.
Luc
L
Sips
Janssen Research & Development, Spring House, PA, USA.
Naidong
N
Weng
Janssen Research & Development, Beerse, Belgium.
Philip
P
Timmerman
Janssen Research & Development, Beerse, Belgium.
Tom
T
Verhaeghe
D000225:Adenine / Q000031:analogs & derivatives; D000077329:Agammaglobulinaemia Tyrosine Kinase; D001647:Bile Acids and Salts / Q000737:chemistry; D001774:Blood Chemical Analysis / Q000379:methods* / Q000592:standards; D002138:Calibration; D002851:Chromatography, High Pressure Liquid / Q000592:standards; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D010880:Piperidines; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D011720:Pyrazoles / Q000097:blood* / Q000378:metabolism; D011743:Pyrimidines / Q000097:blood* / Q000378:metabolism; D011786:Quality Control; D053719:Tandem Mass Spectrometry / Q000592:standards; D013656:Taurocholic Acid / Q000737:chemistry
D001647:Bile Acids and Salts; D010880:Piperidines; D011720:Pyrazoles; D011743:Pyrimidines; C551803:ibrutinib; D013656:Taurocholic Acid; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; D000225:Adenine