Progress in Understanding the Genetic Information and Biosynthetic Pathways behind Amycolatopsis Antibiotics, with Implications for the Continued Discovery of Novel Drugs.
Species of Amycolatopsis, well recognized as producers of both vancomycin and rifamycin, are also known for producing other secondary metabolites, with wide usage in medicine and agriculture. The molecular genetics of natural antibiotics produced by this genus have been well studied. Since the rise of antibiotic resistance, finding new drugs to fight infection has become an urgent priority. Progress in understanding the biosynthesis of metabolites greatly helps the rational manipulation of biosynthetic pathways, and thus to achieve the goal of generating novel natural antibiotics. The efforts made in exploiting Amycolatopsis genome sequences for the discovery of novel natural products and biosynthetic pathways are summarized.
College of Pharmaceutical Science, Zhejiang University of Technology, Chaowang Road No.18, Xiacheng District, Hangzhou, 310014, Zhejiang, China.
Su
S
Chen
College of Pharmaceutical Science, Zhejiang University of Technology, Chaowang Road No.18, Xiacheng District, Hangzhou, 310014, Zhejiang, China.
Qihao
Q
Wu
College of Pharmaceutical Science, Zhejiang University of Technology, Chaowang Road No.18, Xiacheng District, Hangzhou, 310014, Zhejiang, China.
Qingqing
Q
Shen
College of Pharmaceutical Science, Zhejiang University of Technology, Chaowang Road No.18, Xiacheng District, Hangzhou, 310014, Zhejiang, China. hongw@zjut.edu.cn.
Hong
H
Wang
D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D053898:Biosynthetic Pathways; D055808:Drug Discovery; D012293:Rifampin / Q000737:chemistry; D014640:Vancomycin / Q000737:chemistry
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D012293:Rifampin
Amycolatopsis; antibiotics; biosynthesis; chemical structures; genome sequences