Guided tissue regeneration in heart valve replacement: from preclinical research to first-in-human trials.
Heart valve tissue-guided regeneration aims to offer a functional and viable alternative to current prosthetic replacements. Not requiring previous cell seeding and conditioning in bioreactors, such exceptional tissue engineering approach is a very fascinating translational regenerative strategy. After in vivo implantation, decellularized heart valve scaffolds drive their same repopulation by recipient's cells for a prospective autologous-like tissue reconstruction, remodeling, and adaptation to the somatic growth of the patient. With such a viability, tissue-guided regenerated conduits can be delivered as off-the-shelf biodevices and possess all the potentialities for a long-lasting resolution of the dramatic inconvenience of heart valve diseases, both in children and in the elderly. A review on preclinical and clinical investigations of this therapeutic concept is provided with evaluation of the issues still to be well deliberated for an effective and safe in-human application.
Department of Cardiac, Thoracic and Vascular Sciences, University Hospital of Padua, Via Giustiniani 2, 35128 Padua, Italy.
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Department of Cardiac, Thoracic and Vascular Sciences, University Hospital of Padua, Via Giustiniani 2, 35128 Padua, Italy.
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D000818:Animals; D019544:Equipment Failure Analysis / Q000379:methods; D048091:Guided Tissue Regeneration / Q000295:instrumentation* / Q000379:methods / Q000639:trends; D006349:Heart Valve Diseases / Q000628:therapy*; D006350:Heart Valve Prosthesis / Q000639:trends*; D006801:Humans; D011474:Prosthesis Design / Q000379:methods / Q000639:trends; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods / Q000639:trends; D054457:Tissue Scaffolds / Q000639:trends*