The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration.
Crk adaptor proteins are key players in signal transduction from a variety of cell surface receptors. They are involved in early steps of lymphocyte activation through their SH2-mediated transient interaction with signal transducing effector molecules, such as Cbl, ZAP-70, CasL, and STAT5. In addition, they constitutively associate, via their SH3 domain, with effector molecules, such as C3G, that mediate cell adhesion and regulate lymphocyte extravasation and recruitment to sites of inflammation. Recent studies demonstrated that the conformation and function of CrkII is subjected to a regulation by immunophilins, which also affect CrkII-dependent T-cell adhesion to fibronectin and migration toward chemokines. This article addresses mechanisms that regulate CrkII conformation and function, in general, and emphasizes the role of Crk proteins in receptor-coupled signaling pathways that control T-lymphocyte adhesion and migration to inflammatory sites.
The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, The Cancer Research Center, Ben Gurion University of the Negev , Beer Sheva , Israel.
Alex
A
Braiman
The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, The Cancer Research Center, Ben Gurion University of the Negev , Beer Sheva , Israel ; School of Pharmacy, University of Otago , Dunedin , New Zealand.
Noah
N
Isakov
Crk adaptor proteins; T lymphocytes; cell adhesion; cell migration; cyclophilin A; cyclosporin A; immunophilins; signal transduction