Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity.
Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963-966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830-1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the complex molecular mechanisms that underlie intergenerational transmission of obesity.
Asbestos Diseases Research Institute, NSW, 2139 Sydney, Australia ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW 2052, Australia.
Ruby C Y
RC
Lin
Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia ; Department of Pharmacology, School of Medical Sciences, University New South Wales, NSW 2052, Australia.
Sheau-Fang
SF
Ng
Department of Pharmacology, School of Medical Sciences, University New South Wales, NSW 2052, Australia.
Margaret J
MJ
Morris
Gene signatures; High fat diet; Intergenerational transmission; Islet dysfunction; Paternal transmission