Hybrid aerogel preparations as drug delivery matrices for low water-solubility drugs.
A comprehensive study of 14 hybrid aerogels of different composition with applications in drug delivery has been carried out. The overall objective was to modulate the release behavior of drug-impregnated aerogels, from an almost instantaneous release to a semi-retarded delivery prolonged during several hours, through internal surface functionalization. The designed hybrid aerogels were composed of silica and gelatin and functionalized with either phenyl, long (16) hydrocarbon chain or methyl moiety. As model systems, three class II active agents (pKa<5.5), ibuprofen, ketoprofen and triflusal, were chosen to impregnate the aerogels. The work relied on the use of supercritical fluid technology for both the synthesis and functionalization of the hybrid aerogels, as well as for the impregnation with an active agent using supercritical CO2 as a solvent. For the impregnated aerogels, in vitro release profiles were recorded under gastric and intestinal pH-conditions using HPLC techniques. The release behavior observed for the three studied drugs was explained considering the measured dissolution profiles of the crystalline drugs, the aerogel composition and its functionalization. Such features are considered of great interest to tailor the bioavailability of drugs with low water solubility.
Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, 4032 Debrecen, Hungary; Institut de Ciència de Materials de Barcelona (CSIC), Campus de la UAB, 08193 Bellaterra, Spain.
Peter
P
Veres
Institut de Ciència de Materials de Barcelona (CSIC), Campus de la UAB, 08193 Bellaterra, Spain.
Ana M
AM
López-Periago
Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, 4032 Debrecen, Hungary.
István
I
Lázár
Department of Analytical Chemistry, University of Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain.
Javier
J
Saurina
Institut de Ciència de Materials de Barcelona (CSIC), Campus de la UAB, 08193 Bellaterra, Spain. Electronic address: conchi@icmab.es.
Concepción
C
Domingo
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis*; D016503:Drug Delivery Systems / Q000379:methods*; D005782:Gels / Q000008:administration & dosage / Q000138:chemical synthesis*; D007052:Ibuprofen / Q000008:administration & dosage / Q000138:chemical synthesis; D012995:Solubility; D014961:X-Ray Diffraction / Q000379:methods
D004337:Drug Carriers; D005782:Gels; D007052:Ibuprofen
Acid drugs; Gelatin; Hybrid aerogel; Silica; Supercritical CO(2)