The amount and duration of smoking is associated with aggravation of hormone and biochemical profile in women with PCOS.
We investigated the association between the amount and duration of smoking on biochemical, clinical parameters and the ovarian morphology in women with polycystic ovary syndrome (PCOS). That was a retrospective study. These women were divided into two groups, non-smokers (217) and smokers (92). The amount of cigarettes and duration of smoking was measured in pack-years. Both groups underwent clinical evaluation, biochemical and hormone analysis, transvaginal ultrasound and oral glucose tolerance tests (OGTT). The mean value of the number of cigarettes was 14.8 (±8.8) and the median value of pack-years in the smokers group was 4.0 (1.5-7.5). Smokers group has significantly higher free testosterone (F-T), 17-hydroxyprogesterone (17-OHP), delta 4 androstenedione (Δ4-A), T4, low-density lipoprotein (LDL), and white blood cells (WBC). During correlation of all the above parameters and pack-years, there has been significant positive correlation in F-T and Δ4-A. The participants with more pack-years showed statistically higher values of F-T and Δ4-A. There was also a significant positive correlation between total cholesterol, triglycerides, WBC and pack-years of the participants. Prolactin (PRL) has been inversely associated with pack-years. We concluded that the increase of pack-years aggravated lipid profile, WBC and decreased PRL levels, in PCOS patients.
a 3rd Department of Obstetrics and Gynecology and.
Dimitrios
D
Xirofotos
a 3rd Department of Obstetrics and Gynecology and.
Eftihios
E
Trakakis
b 2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital , Athens , Greece.
Moli
M
Peppa
a 3rd Department of Obstetrics and Gynecology and.
Charalambos
C
Chrelias
a 3rd Department of Obstetrics and Gynecology and.
Pericles
P
Panagopoulos
a 3rd Department of Obstetrics and Gynecology and.
Chrysi
C
Christodoulaki
a 3rd Department of Obstetrics and Gynecology and.
Dimos
D
Sioutis
a 3rd Department of Obstetrics and Gynecology and.
Dimitrios
D
Kassanos
D000328:Adult; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects*; D055815:Young Adult
Biochemical profile; PCOS women; hormones; smoking