Trifunctional Polymeric Nanocomposites Incorporated with Fe₃O₄/Iodine-Containing Rare Earth Complex for Computed X-ray Tomography, Magnetic Resonance, and Optical Imaging.
In this study, a novel polymerizable CT contrast agent integrating iodine with europium(III) has been developed by a facile and universal coordination chemistry method. The Fe3O4 nanoparticles are then incorporated into this iodine-containing europium complex by seed-emulsifier-free polymerization. The nanocomposites combining the difunctional complex and superparamagnetic Fe3O4 nanoparticles, which have uniform size dispersion and high encapsulation rate, are suitable for computed X-ray tomography (CT), magnetic resonance imaging (MRI), and optical imaging. They possess good paramagnetic properties with a maximum saturation magnetization of 2.16 emu/g and a transverse relaxivity rate of 260 mM(-1) s(-1), and they exhibit obvious contrast effects with an iodine payload less than 4.8 mg I/mL. In the in vivo optical imaging assessment, vivid fluorescent dots can be observed in the liver and spleen by two-photon confocal scanning laser microscopy (CLSM). All the results showed that nanocomposites as polymeric trifunctional contrast agents have great clinical potential in CT, MR, and optical imaging.
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Materials, Hubei University , Wuhan, Hubei 430062, China.
Xin
X
Wang
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei 430030, China.
Mengqi
M
Tu
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Materials, Hubei University , Wuhan, Hubei 430062, China.
Kai
K
Yan
Department of Physics and Materials Science, City University of Hong Kong , Tat Chee Avenue, Kowloon, Hong Kong, China.
Penghui
P
Li
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Materials, Hubei University , Wuhan, Hubei 430062, China.
Long
L
Pang
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Materials, Hubei University , Wuhan, Hubei 430062, China.
Ying
Y
Gong
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Materials, Hubei University , Wuhan, Hubei 430062, China.
Qing
Q
Li
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Materials, Hubei University , Wuhan, Hubei 430062, China.
Ruiqing
R
Liu
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Materials, Hubei University , Wuhan, Hubei 430062, China.
Zushun
Z
Xu
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, Hubei 430030, China.
Haibo
H
Xu
Department of Physics and Materials Science, City University of Hong Kong , Tat Chee Avenue, Kowloon, Hong Kong, China.
Paul K
PK
Chu
D002470:Cell Survival; D018920:Coculture Techniques; D003287:Contrast Media / Q000737:chemistry; D005063:Europium / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007455:Iodine / Q000737:chemistry*; D007462:Iodobenzenes / Q000737:chemistry; D007477:Ions; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D061848:Optical Imaging / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014961:X-Ray Diffraction
D003287:Contrast Media; D007462:Iodobenzenes; D007477:Ions; D011108:Polymers; D005063:Europium; D007455:Iodine; D052203:Ferrosoferric Oxide
computed X-ray tomography imaging; iodine-containing contrast agents; magnetic resonance imaging; polymeric nanocomposites; rare-earth fluorescent