Sleep disorders: A review of the interface between restless legs syndrome and iron metabolism.
Restless legs syndrome (RLS) is characterized by unpleasant sensations mainly in the legs. 43% of RLS-associated conditions have also been associated with systemic iron deficiency. The objective of this study was to review in the literature the relationship between iron metabolism and RLS. With an initial search using the keywords combination "Iron Metabolism OR Iron Deficiency AND Restless Legs Syndrome," 145 articles were screened, and 20 articles were selected. Few studies were found for this review in the period of 2001-2014, however, the correlation between RLS and iron was evident.
Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Brazil.
Paulo
P
Daubian-Nosé
Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Brazil.
Miriam K
MK
Frank
Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Brazil.
Andrea Maculano
AM
Esteves
Attention Deficit Hyperactivity Disorder; Iron Deficiency Anemia; Iron Genes; Pregnancy; Restless Legs Syndrome; Supplementation