Tendon Reconstruction with Tissue Engineering Approach--A Review.
Tendon injuries are a common and rising occurrence, associated with significant impairment to quality of life and financial burden to the healthcare system. Clinically, they represent an unresolved problem, due to poor natural tendon healing and the inability of current treatment strategies to restore the tendon to its native state. Tissue engineering offers a promising alternative, with the incorporation of scaffolds, cells and growth factors to support the complete regeneration of the tendon. The materials used in tendon engineering to date have provided significant advances in structural integrity and biological compatibility and in many cases the results obtained are superior to those observed in natural healing. However, grafts fail to reproduce the qualities of the pre-injured tendon and each has weaknesses subject to its constituent parts. Furthermore, many materials and cell types are being investigated concurrently, with seemingly little association or comparison between research results. In this review the properties of the most-investigated and effective components have been appraised in light of the surrounding literature, with research from early in-vitro experiments to clinical trials being discussed. Extensive comparisons have been made between scaffolds, cell types and growth factors used, listing strengths and weaknesses to provide a stable platform for future research. Promising future endeavours are also described in the field of nanocomposite material science, stem cell sources and growth factors, which may bypass weaknesses found in individual elements. The future of tendon engineering looks bright, with growing understanding in material technology, cell and growth factor application and encouraging recent advances bringing us ever closer to regenerating the native tendon.
Gunay
G
Verdiyeva
Kiron
K
Koshy
Natalia
N
Glibbery
Haroon
H
Mann
Alexander M
AM
Seifalian
D000818:Animals; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006801:Humans; D036103:Nanotechnology / Q000379:methods*; D011474:Prosthesis Design; D019651:Plastic Surgery Procedures / Q000295:instrumentation*; D013708:Tendon Injuries / Q000628:therapy*; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds