Daclatasvir and asunaprevir for recurrent hepatitis C following living donor liver transplantation with HIV co-infection.
Antiviral treatment in liver transplant recipients co-infected with hepatitis C virus (HCV) and HIV remains a challenge. We herein report a case of HCV recurrence that was successfully treated using interferon-free anti-HCV therapy with daclatasvir and asunaprevir. A 48-year-old man underwent antiviral therapy with a 24-week course of daclatasvir and asunaprevir for biopsy-proven recurrent HCV 15 months after living donor liver transplantation, following non-response to pre-emptive antiviral treatment with pegylated interferon plus ribavirin. Anti-HIV and immunosuppressive regimens were modified safely. Renal function was feasibly preserved. The anti-HCV effect was remarkable with an undetectable viral load confirmed within 2 weeks, and this patient achieved a sustained virological response after 12 weeks of post-transplantation treatment. No serious adverse events were observed. This case indicates that daclatasvir and asunaprevir for recurrent HCV in a HIV co-infected recipient after liver transplantation is safe and effective.
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Tomohiro
T
Tanaka
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Nobuhisa
N
Akamatsu
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Junichi
J
Kaneko
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Junichi
J
Arita
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Sumihito
S
Tamura
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Kiyoshi
K
Hasegawa
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Yoshihiro
Y
Sakamoto
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Norihiro
N
Kokudo
HIV; asunaprevir; co-infection; daclatasvir; living donor liver transplantation