Common and Rare Genetic Variants Associated With Alzheimer's Disease.
Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis of the disease before damaging of the brain, and the failure to explore its complex underlying molecular mechanisms. Recent technological advances in genome-wide association studies (GWAS) and high throughput next generation whole genome, and exome sequencing had deciphered many of AD-related loci, and discovered single nucleotide polymorphisms (SNPs) that are associated with altered AD molecular pathways. Highlighting altered molecular pathways linked to AD pathogenesis is crucial to identify novel diagnostic and therapeutic AD targets.
Biomedical Research Center, Qatar University, Doha, Qatar.
Hany E
HE
Marei
Biomedical Research Center, Qatar University, Doha, Qatar.|Department of Health Sciences, College of Arts and Science, Qatar University, Doha, Qatar.
Asmaa
A
Althani
Department of Neurology, Al-Ahli Hospital, Doha, Qatar.
Jaana
J
Suhonen
Biomedical Research Center, Qatar University, Doha, Qatar.
Mohamed E
ME
El Zowalaty
Department of Psychiatry, Hamad Medical Corporation, Doha, Qatar.
Mohammad A
MA
Albanna
CNR-Institute of Translational Pharmacology, Via Fosso del Cavaliere, Roma-Italy.
Carlo
C
Cenciarelli
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee.
Tengfei
T
Wang
Department of Biomedical Sciences, Virginia Tech Carilion School of Medicine, Roanoke, Virginia.
Thomas
T
Caceci
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D015398:Signal Transduction