Multidisciplinary approach of lumbo-sacral chordoma: From oncological treatment to reconstructive surgery.
Lumbo-sacral chordoma is a rare, slow-growing tumor, arising from embryonic nothocordal remnants. Wide en bloc excision with clear margins remains mandatory to achieve satisfactory recurrence rates and disease-free survival. No chemotherapy has been demonstrated to be effective and radiotherapy is only marginally effective. Tyrosine kinase receptor inhibitors have showed encouraging results in locally advanced and metastatic chordoma. Reconstructive surgery may become very complex. Multidisciplinary approach in tertiary hospitals is always necessary.
Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Fabio
F
Garofalo
Department of Plastic and Reconstructive Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Pietro G
PG
di Summa
Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.|Department of Surgery, Hospital Civico, Lugano, Switzerland.
Dimitrios
D
Christoforidis
Department of Oncology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Marc
M
Pracht
Department of Orthopedics, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Pietro
P
Laudato
Department of Orthopedics, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Stéphane
S
Cherix
Department of Radio-Oncology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Hanan
H
Bouchaab
Department of Plastic and Reconstructive Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Wassim
W
Raffoul
Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Nicolas
N
Demartines
Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Maurice
M
Matter
D002817:Chordoma / Q000601:surgery* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D011183:Postoperative Complications; D011379:Prognosis; D019651:Plastic Surgery Procedures; D012447:Sacrum / Q000601:surgery*; D013125:Spinal Neoplasms / Q000601:surgery* / Q000628:therapy
chordoma; sacrum; spine