Platinum(IV) Carboxylate Prodrug Complexes as Versatile Platforms for Targeted Chemotherapy.
Kinetically-inert Pt(IV) carboxylate complexes have emerged in recent years as candidates for the development of next-generation platinum anticancer drugs. Being native prodrugs of clinically-important Pt(II) chemotherapeutic agents, the Pt(IV) scaffold can be exploited to incorporate additional functionalities while keeping the Pt(II) pharmacophore intact. This mini-review examines recent work performed to illuminate the mechanism of Pt(IV) prodrug activation and their use as versatile platforms for targeted chemotherapy.
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Jun Xiang
JX
Ong
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Siew Qi
SQ
Yap
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Daniel Yuan Qiang
DY
Wong
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Chee Fei
CF
Chin
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543; NUS Graduate School of Integrative Sciences and Engineering, Centre for Life Sciences (CeLS), 28 Medical Drive, Singapore 117456. chmawh@nus.edu.sg.
Wee Han
WH
Ang