Association analysis of IL-17A and IL-17F polymorphisms in Chinese women with cervical cancer.
We selected six tagged single nucleotide polymorphisms (SNPs) in the interleukin 17A (IL-17A) and IL-17F genes, and evaluated the relationship between the six common SNPs and environmental factors in cervical cancer patients. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the IL-17A (rs2275913, rs3748067, and rs3819025) and IL-17F (rs763780, rs9382084, and rs1266828) SNPs. The associations between IL-17A and IL-17F gene polymorphisms and risk of cervical cancer were estimated by conditional logistic regression. Compared with the control subjects, the cervical cancer patients had a lower age at first live birth, a habit of smoking, a family history of cancer, and a greater incidence of human papillomavirus-16 or 18 infections. The logistic regression analysis showed that the variant AA genotype of rs2275913 was associated with a significantly higher risk of cervical cancer than the wild-type GG genotype (OR = 1.99, 95%CI = 1.12-3.50). However, no evidence of the association was observed between rs3748067, rs3819025, rs763780, rs9382084, and rs1266828 polymorphisms and the risk of cervical cancer. We suggest that rs2275913 may play a role in the etiology of cervical cancer. These findings could be helpful in identifying individuals at increased risk of developing cervical cancer.
Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University, Jinan, Shandong, China.
L
L
Li
Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University, Jinan, Shandong, China.
Y L
YL
Tian
Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University, Jinan, Shandong, China.
X M
XM
Lv
Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University, Jinan, Shandong, China.
H F
HF
Yu
Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University, Jinan, Shandong, China.
Y Y
YY
Xie
Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University, Jinan, Shandong, China.
J D
JD
Wang
Department of Obstetrics and Gynecology, Jinan Central Hospital, Shandong University, Jinan, Shandong, China.
W
W
Shi
D002681:China; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17