Association of Interleukin-1 Gene Cluster and Interleukin-1 Receptor Polymorphisms With Febrile Seizures.
Interleukin-1 (IL-1) plays a key role in inflammation, has an effect on a wide variety of cells, and often leads to tissue destruction. While the ratio between IL-1 and IL-1Ra could influence the development of different diseases of the central nervous system, its gene polymorphisms were investigated in a group of patients with febrile seizures. Ninety patients with febrile seizures were enrolled and compared with 140 controls. The allele and genotype frequency of single nucleotide polymorphisms within the IL-1α, β, IL-1 R and IL-1Ra gene were determined. The frequency of the IL-1Ra/C allele at position Mspa-I 11100 was decreased significantly (P= .002) and the IL-1Ra/T frequency was significantly increased in patients (P= .002). In addition, the CT genotype frequency at the same position was significantly overrepresented in controls compared to patients (P= .001). Certain alleles and genotypes in the IL-1 gene were overrepresented in patients with febrile seizures, which possibly could predispose individuals to this disease.
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Samaneh
S
Soltani
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Ameneh
A
Zare-Shahabadi
Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Amin
A
Shahrokhi
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Arezou
A
Rezaei
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Samaneh
S
Zoghi
Division of Pediatric Neurology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Gholam Reza
GR
Zamani
Division of Pediatric Neurology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Mahmoud
M
Mohammadi
Division of Pediatric Neurology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Mahmoud Reza
MR
Ashrafi
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran rezaei_nima@tums.ac.ir.
Nima
N
Rezaei
D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007223:Infant; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D003294:Seizures, Febrile / Q000235:genetics*
D007375:Interleukin-1; D017472:Receptors, Interleukin-1
febrile seizure; gene polymorphisms; interleukin-1 receptor agonist; interleukin-1receptor; interleukin-1α; interleukin-1β