Significant Shrinkage of Multifocal Liver Metastases and Long-Term Survival in a Patient With Rectal Cancer, After Trans-Arterial Chemoembolization (TACE): A Case Report.
In this paper, we present the successful therapeutic approach of unresectable liver metastases in a patient with rectal cancer.A 63-year-old male underwent endoscopic polypectomy followed by rectosigmoid resection for an adenocarcinoma of the rectum diagnosed in pT2N0 stage. The angio-computed tomography (CT) revealed four metastatic hepatic nodules ranging from 12 to 130 mm in diameter. After one cure of trans-arterial chemoembolization (TACE) with lipiodol and 5-fluorouracil, combined with FOLFOX4 + capecitabine systemic chemotherapy, the diameter of all hepatic nodules decreased to half size, at 6 months after TACE. Further curative surgical hepatic metastasectomy was done and complete pathologic response was obtained. The patient is free of recurrences and metastases after 26 months of follow-up.This representative case shows that an efficient trans-disciplinary approach could lead to successful therapeutic management even in patients with advanced-staged colorectal carcinomas.
From the Department of Surgery, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania (BAS, CM); Department of Anatomy and Embryology, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania (BAS, IH, KB); Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania (SG, DM, IJ); and Department of Radiology, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania (LM, IH).
Bogdan Andrei
BA
Suciu
Simona
S
Gurzu
Lucian
L
Marginean
Doina
D
Milutin
Ioana
I
Halmaciu
Ioan
I
Jung
Klara
K
Branzaniuc
Calin
C
Molnar
D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods; D018572:Disease-Free Survival; D006499:Hepatic Artery; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology*; D012074:Remission Induction; D013997:Time Factors