Treatment of pressure ulcers in patients with declining renal function using arginine, glutamine and ß-hydroxy-ß-methylbutyrate.
The aim of this study is to examine the efficacy on healing pressure ulcers (PU) of using a supplement combination containing arginine, glutamine and ß-hydroxy-ß-methylbutyrate, which was given to two elderly patients with renal dysfunction. The PU was surgically opened, decompressed and treated by drugs. A half quantity of the defined dose of the supplement combination, with an enteral nutrition product, was administered to the patients twice a day. This combination improved the PUs, with no effect on renal function. This novel finding may provide a nutritional rationale of arginine, glutamine and ß-hydroxy-ß-methylbutyrate for PUs associated with renal dysfunction.
Assistant Professor, Professor, Department of Nutritional Sciences Faculty of Human Ecology, Yasuda Women's University, Hiroshima, Japan.
Y
Y
Ogura
Certified Nutrition Support Team Dietitian of JSPEN, Registered Dietitian, Department of Nutrition, Hibino Hospital, Hiroshima, Japan.
N
N
Yuki
Certified Nutrition Support Team Occupational Therapist of JSPEN, Department of Rehabilitation, Hibino Hospital, Hiroshima, Japan.
A
A
Sukegane
Pharmacist, Certified Nutrition Support Team Nurse, Department of Nursing, Hibino Hospital, Hiroshima, Japan.
T
T
Nishi
Department of Pharmacy, Hibino Hospital, Hiroshima, Japan.
Y
Y
Miyake
Department of Neurosurgery, Hibino Hospital, Hiroshima, Japan.
H
H
Sato
Nurse, Department of Nursing, Sin-ai nursing home, Hiroshima, Japan.
C
C
Miyamoto
Assistant Professor, Professor, Department of Nutritional Sciences Faculty of Human Ecology, Yasuda Women's University, Hiroshima, Japan.
C
C
Mihara
D000369:Aged, 80 and over; D001120:Arginine / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D005527:Food, Fortified; D005973:Glutamine / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D003668:Pressure Ulcer / Q000150:complications / Q000178:diet therapy*; D016896:Treatment Outcome; D014631:Valerates / Q000627:therapeutic use*; D014945:Wound Healing
D014631:Valerates; D005973:Glutamine; C004961:beta-hydroxyisovaleric acid; D001120:Arginine
arginine; glutamine; pressure ulcer; renal dysfunction; ß-hydroxy-ß-methylbutyrate (HMB)