Control of Cell Survival in Adult Mammalian Neurogenesis.
The fact that continuous proliferation of stem cells and progenitors, as well as the production of new neurons, occurs in the adult mammalian central nervous system (CNS) raises several basic questions concerning the number of neurons required in a particular system. Can we observe continued growth of brain regions that sustain neurogenesis? Or does an elimination mechanism exist to maintain a constant number of cells? If so, are old neurons replaced, or are the new neurons competing for limited network access among each other? What signals support their survival and integration and what factors are responsible for their elimination? This review will address these and other questions regarding regulatory mechanisms that control cell-death and cell-survival mechanisms during neurogenesis in the intact adult mammalian brain.
Center for Brain Repair and Rehabilitation, Department of Neuroscience and Physiology, University of Gothenburg, Gothenburg 413 90, Sweden.
H Georg
HG
Kuhn
D017209:Apoptosis; D049109:Cell Proliferation; D002470:Cell Survival; D002490:Central Nervous System / Q000166:cytology*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000502:physiology; D017628:Microglia / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism / Q000502:physiology; D055495:Neurogenesis; D015398:Signal Transduction
D036341:Intercellular Signaling Peptides and Proteins; D009414:Nerve Growth Factors