The association between Metabolic Syndrome and serum levels of lipid peroxidation and interleukin-6 in Gorgan.
BACKGROUND
There are limited studies on the relationship between inflammatory marker such as IL-6 and lipid peroxidation and metabolic syndrome.


OBJECTIVE
The aim of present study was to assess IL-6 and lipid peroxidation in subjects with and without the metabolic syndrome and their association with metabolic syndrome components.


METHODS
Age and gender matched 40 subjects with metabolic syndrome and 40 control groups took part in this study.


RESULTS
The mean malondialdehyde level was significantly higher in overweight and obese subjects with metabolic syndrome than control groups (P<0.05). The mean level of IL-6 in men and the mean level of malondialdehyde in women with metabolic syndrome was significantly higher than control groups (p<0.05). There were significant positive correlation between malondialdehyde and fasting blood glucose, triglyceride and systolic blood pressure (p<0.05).


CONCLUSIONS
Our results suggest that higher levels of IL-6 and malondialdehyde may cause insulin resistance and metabolic disorders in all subjects with metabolic syndrome. Malondialdehyde level shows strong association with some metabolic syndrome components. This means the greater risk of metabolic syndrome.
Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan province, Iran.
Hamide Mojaz
HM
Sarbijani
Golestan Research Center of Gastroenterology and Hepatology, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan province, Iran.
Masoud
M
Khoshnia
Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan province, Iran. Electronic address: abdoljalal@yahoo.com.
Abdoljalal
A
Marjani
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007492:Iran; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D012307:Risk Factors
D001786:Blood Glucose; C508600:IL6 protein, human; D015850:Interleukin-6; D008315:Malondialdehyde
Gorgan; Interleukin-6; Lipid peroxidation; Metabolic syndrome