[Effect of Osteoking on Bone Mineral Density and Dickkopf-1 Protein Levels in Rabbits with Osteoporotic Fracture].
OBJECTIVE
To explore the effect of Osteoking on bone mineral density (BMD) and serum Dickkopf-1 (DKK-1) protein levels in rabbits with osteoporotic fracture (OPF).


METHODS
Totally 45 female Japanese big-ear rabbits were randomly divided into the treatment group, the model group, and the blank control group (as the control group), 15 in each group. Bilateral ovaries were ectomized for 24 weeks in the treatment group and the model group. Their left radial factures were induced after confirmed osteoporosis. Rabbits in the treatment group were administered with Osteoking by gastrogavage, once per two days. Equal volume of normal saline was given to rabbits in the model group. The general BMD and serum DKK-1 protein levels were detected before ovariectomy, at week 24 and 48 after ovariectomy.


RESULTS
There was significant difference in the general BMD at week 24 after ovariectomy between the model group and the control group, and it was lower in the model group. Compared with the model group, the general BMD significantly increased and serum DKK-1 protein levels significantly decreased in the treatment group after intervention. Serum DKK-1 protein levels were significantly lower after intervention than before intervention in the treatment group.


CONCLUSIONS
Osteoking could improve the BMD of OPF rabbits, and reduce their serum DKK-1 protein levels as well.
Su-bin
SB
Wang
Hong-bin
HB
Zhao
Min
M
Hu
Wei
W
Wei
Chuang-yun
CY
Qian
Gang
G
Jiang
Yang
Y
Zhang
Lin
L
Zhao
Lei
L
Guo
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D010024:Osteoporosis; D058866:Osteoporotic Fractures / Q000188:drug therapy* / Q000378:metabolism; D010052:Ovariectomy; D011817:Rabbits
C501126:DKK1 protein, human; D004365:Drugs, Chinese Herbal; D036341:Intercellular Signaling Peptides and Proteins; C510023:osteoking