Human papillomavirus-associated neoplasms of the sinonasal tract and nasopharynx.
It is now well established that human papillomavirus (HPV) is an important causative factor in a subgroup of head and neck cancer. In the head and neck, while HPV is strongly associated with squamous cell carcinoma arising in the oropharynx, there is a growing interest in HPV-associated neoplasms of non-oropharyngeal origin including those which arise within sinonasal and nasopharyngeal mucosa. This article reviews current literature on the association of HPV with Scheiderian papillomas, sinonasal squamous cell carcinoma, sinonasal undifferentiated carcinoma, carcinoma with adenoid cystic-like features, and nasopharyngeal carcinoma. Several clinical implications of HPV detection in sinonasal and nasopharyngeal carcinomas are briefly discussed.
Head and Neck Pathology, Guy׳s and St Thomas׳ NHS Foundation Trust, 4th Floor Tower Wing, Guy׳s Hospital, Great Maze Pond, London SE1 9RT, UK; Oral and Maxillofacial Pathology, King׳s College London, London, UK. Electronic address: selvam.thavaraj@kcl.ac.uk.
Selvam
S
Thavaraj
D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D004279:DNA, Viral / Q000235:genetics; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D007150:Immunohistochemistry; D009296:Nasal Cavity / Q000737:chemistry / Q000473:pathology / Q000821:virology*; D009669:Nose Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology / Q000821:virology*; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D010255:Paranasal Sinus Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology / Q000821:virology*; D011237:Predictive Value of Tests; D012307:Risk Factors
D014408:Biomarkers, Tumor; D004279:DNA, Viral
HPV; Human papillomavirus; nasopharyngeal; sinonasal