New cytotoxic clerodane diterpenes from the leaves of Premna tomentosa.
Bio-activity directed investigation of hexane extract from the leaves of Premna tomentosa led to the isolation of three new clerodane diterpenes (1-3) along with four known compounds (4-7). The structures of new compounds were established using IR, MS, 1D, and 2D NMR techniques. The in vitro cytotoxicity of the crude hexane extract and the isolated compounds were evaluated against seven human cancer cell lines and results indicated that compounds 2 and 4 depicted significant cytotoxicity against hepatocellular carcinoma cell line.
a Division of Natural Product Chemistry, CSIR - Indian Institute of Chemical Technology , Tarnaka , Hyderabad 500607 , India.
K
K
Rekha
a Division of Natural Product Chemistry, CSIR - Indian Institute of Chemical Technology , Tarnaka , Hyderabad 500607 , India.
Pandey
P
Richa
a Division of Natural Product Chemistry, CSIR - Indian Institute of Chemical Technology , Tarnaka , Hyderabad 500607 , India.
A
A
Hymavathy
a Division of Natural Product Chemistry, CSIR - Indian Institute of Chemical Technology , Tarnaka , Hyderabad 500607 , India.
K
K
Suresh Babu
a Division of Natural Product Chemistry, CSIR - Indian Institute of Chemical Technology , Tarnaka , Hyderabad 500607 , India.
J
J
Madhusudana Rao
b Center for Chemical Biology, CSIR - Indian Institute of Chemical Technology , Tarnaka , Hyderabad 500607 , India.|c Academy of Scientific & Innovative Research (AcSIR) , NewDelhi 110001 , India.
Dhoke
D
Neha R
b Center for Chemical Biology, CSIR - Indian Institute of Chemical Technology , Tarnaka , Hyderabad 500607 , India.|c Academy of Scientific & Innovative Research (AcSIR) , NewDelhi 110001 , India.
Das
D
Amitava
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007194:India; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane
Premna tomentosa; Verbenaceae; clerodane diterpenes; cytotoxicity