[Gaba and its Receptors in Pathogenesis of Epilepsy].
This review presents summarizes data on the structural and functional organization of the GABAergic system of the brain, mechanisms of GABAergic transmission, about the characteristics of GABA-receptors and GABAergic inhibition forms. Reviewed issues of involvement of GABA inhibitory neurotransmitter and various types of GABA-receptors in epileptogenesis. The experimental and clinical data testifying to an important role of GABA and its receptors in an epileptogenesis are presented.
M N
MN
Karpova
L V
LV
Kuznetzova
N Yu
NY
Klishina
D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D004827:Epilepsy / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D011963:Receptors, GABA-A / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid