Drinking water toxicity study of the environmental contaminant--Bromate.
Bromate is a byproduct of water disinfection that is produced when waters contain bromide treated with ozone. To investigate the level of the toxicity of bromate and find the most sensitive indicators in a short time, a series of toxicological assessments were conducted including the acute toxicity, cumulative toxicity, genetic toxicity and subacute toxicity of bromate (using Potassium Bromate to represent bromate). The LD50 of orally administered Potassium Bromate was 215 mg/kg in Wistar rats and 464 mg/kg in ICR mice. The cumulative toxicity of Potassium Bromate was not obvious. The Ames test, mouse bone marrow cell micronucleus test and mouse sperm abnormality test did not indicate mutagenicity. The results of the subacute study did not exhibit significant differences in most of the parameters, except the white blood cell count, which was significantly decreased in male rats. In addition, Potassium Bromate influenced the albumin, creatinine, total cholesterol, triglycerides and glucose levels in male rats to various extents. A thorough analysis of the above tests clearly demonstrates that bromate has toxicity, not obvious cumulative toxicity and the white blood cell count can be used as an indicator to reflect the toxicity of bromate and investigate bromate's toxic mechanism.
State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, PR China. Electronic address: mei18@hit.edu.cn.
Liu
L
Dongmei
State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, PR China.
Wang
W
Zhiwei
Key Laboratory of Chemical Engineering Process & Technology for High-efficiency Conversion, School of Chemistry and Material Sciences, Heilongjiang University, Harbin 150080, PR China.
Zhu
Z
Qi
State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, PR China. Electronic address: hit_cuifuyi@hotmail.com.
Cui
C
Fuyi
School of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, PR China.
Shan
S
Yujuan
Shenzhen Water (Group) Co., Ltd., Shenzhen 518031, PR China.
Liu
L
Xiaodong
D000284:Administration, Oral; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D001959:Bromates / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D004435:Eating / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D008813:Mice, Inbred ICR; D015162:Micronucleus Tests; D017208:Rats, Wistar; D018570:Risk Assessment; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D023382:Toxicity Tests, Acute / Q000379:methods; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000633:toxicity*; D018508:Water Purification
D015415:Biomarkers; D001959:Bromates; D014874:Water Pollutants, Chemical; C019536:potassium bromate
Bromate; Contamination; Drinking water; Mice; Rats; Toxicology