Targets to treat metabolic syndrome in polycystic ovary syndrome.
BACKGROUND
Metabolic syndrome is comprised of a combination of the following states: increased insulin resistance, dyslipidemia, cardiovascular disease, and increased abdominal obesity. Women with polycystic ovary syndrome (PCOS) have an increased risk of developing metabolic syndrome over the course of their lives. Metabolic syndrome increases risk of major cardiovascular events, morbidity, quality of life, and overall health care costs. Though metabolic syndrome in women with PCOS is an area of great concern, there is no effective individual medical therapeutic to adequately treat this issue.


METHODS
This article will review key aspects of metabolic syndrome in PCOS. We will discuss classic and novel therapeutics to address metabolic syndrome in women with PCOS. We will conclude with the importance of developing strategic interventions to increase the compliance to lifestyle and dietary modification, in addition to appreciation of the emerging pharmaceutical therapeutics available.


CONCLUSIONS
Innovation in lifestyle modification, including diet, exercise, with and without dedicated stress reduction techniques is the future in treatment of metabolic syndrome in PCOS. Application of novel interventions, such as group medical care, may improve future adherence to lifestyle modification recommendations, in addition to or in combination with pharmaceutical therapeutics.
a Department of Obstetrics and Gynecology , Boston University School of Medicine , Boston , MA 02118 , USA.
Shruthi
S
Mahalingaiah
b Department of Endocrinology, Diabetes & Metabolism , University of Athens Medical School , Athens 11521 , Greece.
Evanthia
E
Diamanti-Kandarakis
D000818:Animals; D015195:Drug Design; D005260:Female; D006801:Humans; D008019:Life Style; D024821:Metabolic Syndrome / Q000150:complications / Q000209:etiology / Q000628:therapy*; D058990:Molecular Targeted Therapy; D010349:Patient Compliance; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011788:Quality of Life
group care; lifestyle modification; metabolic syndrome; polycystic ovary syndrome