Flare-up reactions in severe drug hypersensitivity: infection or ongoing T-cell hyperresponsiveness.
"Flare-up" reactions are late manifestations of severe T-cell-mediated drug hypersensitivity reactions. Management is anti-inflammatory treatment and avoiding unnecessary medicines. Symptoms like fever, lymph node swelling, and blood count abnormalities may lead to confusion with bacterial infections. For prompt recognition it is important to keep the differential diagnosis in mind.
Department of Rheumatology, Immunology and Allergology, Inselspital, University Hospital of Bern Bern, Switzerland.
Lukas
L
Jörg-Walther
Department of Rheumatology, Immunology and Allergology, Inselspital, University Hospital of Bern Bern, Switzerland.
Benno
B
Schnyder
Department of Rheumatology, Immunology and Allergology, Inselspital, University Hospital of Bern Bern, Switzerland.
Arthur
A
Helbling
Department of Visceral Surgery and Medicine, Inselspital, University Hospital of Bern Bern, Switzerland.
Karin
K
Helsing
Department of Visceral Surgery and Medicine, Inselspital, University Hospital of Bern Bern, Switzerland.
Alexandra
A
Schüller
Department of Visceral Surgery and Medicine, Inselspital, University Hospital of Bern Bern, Switzerland.
Annette
A
Wochner
ADR-AC GmbH, Adverse Drug Reactions, Analysis and Consulting Bern, Switzerland.
Werner
W
Pichler
Drug hypersensitivity; T cell; drug rash with eosinophilia and systemic symptoms (DRESS); flare-up reaction; infection; relapse