Local Control Rates of Metastatic Renal Cell Carcinoma (RCC) to Thoracic, Abdominal, and Soft Tissue Lesions Using Stereotactic Body Radiotherapy (SBRT).
OBJECTIVE
We report the radiographic response rate of SBRT compared to conventional fractionated radiotherapy (CF-EBRT) for thoracic, abdominal, skin and soft tissue RCC lesions treated at our institution.


METHODS
Fifty three lesions where included in the study (36 SBRT, 17 CF-EBRT), treated from 2004 to 2014 at our institution. We included patients that had thoracic, skin & soft tissue (SST), and abdominal metastases of histologically confirmed RCC. The most common SBRT fractionation was 50 Gy in 5 fractions.


RESULTS
The median time of follow-up was 16 months (range 3-97 months). Median BED was 216.67 (range 66.67-460.0) for SBRT, and 60 (range 46.67-100.83) for CF-EBRT. Median radiographic local control rates at 12, 24, and 36 months were 100, 93.41, and 93.41 % for lesions treated with SBRT versus 62.02, 35.27 and 35.27 % for those treated with CF-EBRT (p < 0.001). Predictive factors for radiographic local control under univariate analysis included BED ≥ 100 Gy (HR, 0.048; 95 % CI, 0.006-0.382; p = 0.005), dose per fraction ≥ 9 Gy (HR, 0.631; 95 % CI, 0.429-0.931; p = 0.021), and gender (HR, 0.254; 95 % CI, 0.066-0.978; p = 0.048). Under multivariate analysis, there were no significant predictors for local control. Toxicity rates were low and equivalent in both groups, with no grade 4 or 5 side effects reported.


CONCLUSIONS
SBRT is safe and effective for the treatment of RCC metastases to thoracic, abdominal and integumentary soft tissues. Radiographic response rates were greater and more durable using SBRT compared to CF-EBRT. Further prospective trials are needed to evaluate efficacy and safety of SBRT for RCC metastases.
Department of Radiation Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Room 1032, Aurora, CO, 80045, USA.
Basel
B
Altoos
Department of Radiation Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Room 1032, Aurora, CO, 80045, USA.
Arya
A
Amini
University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Muthanna
M
Yacoub
Medical Oncology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Maria T
MT
Bourlon
Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Elizabeth E
EE
Kessler
Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Thomas W
TW
Flaig
Department of Radiation Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Room 1032, Aurora, CO, 80045, USA.
Christine M
CM
Fisher
Department of Radiation Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Room 1032, Aurora, CO, 80045, USA.
Brian D
BD
Kavanagh
Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Elaine T
ET
Lam
Department of Radiation Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Room 1032, Aurora, CO, 80045, USA. sana.karam@ucdenver.edu.
Sana D
SD
Karam
D000008:Abdominal Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D016634:Radiosurgery / Q000379:methods*; D011878:Radiotherapy; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D013899:Thoracic Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery