DISTRIBUTION OF GLIAL FIBRILLARY ACIDIC PROTEIN IN DIFFERENT PARTS OF THE RAT BRAIN UNDER CADMIUM EXPOSURE.
The chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein (GFAP) and their polypeptide fragments in different parts of the rat brain were investigated. Obtained results showed dose-dependent effect of cadmium on the soluble form of GFAP and more pronounced effect on the filament form and composition of the polypeptide fragments of the protein in the rat brain. Prolonged intoxication by cadmium ions in a dose of 1.0 μg/kg of body weight induced a significant decrease in soluble GFAP and an increase in the filament form in the rat brain, pointing to the development of reactive astrogliosis and the risk of neurodegeneration.
Yu P
YP
Kovalchuk
I V
IV
Prischepa
U
U
Si
V S
VS
Nedzvetsky
Y G
YG
Kot
E E
EE
Persky
G A
GA
Ushakova
D000284:Administration, Oral; D000818:Animals; D019256:Cadmium Chloride / Q000633:toxicity*; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism; D017208:Rats, Wistar; D013788:Thalamus / Q000187:drug effects* / Q000378:metabolism
D004785:Environmental Pollutants; D005904:Glial Fibrillary Acidic Protein; D010446:Peptide Fragments; D019256:Cadmium Chloride