Necrotizing fasciitis due to Serratia marcescens: case report and review of the literature.
BACKGROUND
Necrotizing fasciitis is a severe, life-threatening infection.  Serratia marcescens, a Gram-negative bacterium, is an extremely rare cause of necrotizing fasciitis.


METHODS
A case of S. marcescens necrotizing fasciitis is described, and a comprehensive review of the literature (1966-2015) of monomicrobial cases due to this organism performed.


RESULTS
We report the first case of S. marcescens necrotizing fasciitis in the setting of calciphylaxis associated with end-stage renal disease.  A comprehensive review of the literature of S. marcescens necrotizing fasciitis is provided to enhance the awareness of this increasingly recognized infection, and to provide a concise summary of risk factors, treatment, and outcome.


CONCLUSIONS
Our case and review highlight the potential risk factors for S. marcescens necrotizing fasciitis, including underlying renal disease and open wounds, and demonstrate the emergence of this organism as a cause of severe, life-threatening soft tissue infections.
Infectious Diseases Department, Scripps Mercy Hospital, 4077 Fifth Ave, San Diego, CA, 92103, USA. rohitmajumdar5@gmail.com.
Rohit
R
Majumdar
Infectious Diseases Department, Scripps Mercy Hospital, 4077 Fifth Ave, San Diego, CA, 92103, USA. nancy32red@yahoo.com.
Nancy F
NF
Crum-Cianflone
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D019115:Fasciitis, Necrotizing; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D016868:Serratia Infections; D012706:Serratia marcescens
D000900:Anti-Bacterial Agents
Necrotizing fasciitis; Review; Septic shock; Serratia marcescens; Soft tissue infection