New formulation of old aspirin for better delivery.
For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. shanta@uga.edu.
Akil A
AA
Kalathil
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. shanta@uga.edu.
Anil
A
Kumar
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. shanta@uga.edu.
Bhabatosh
B
Banik
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. shanta@uga.edu.
Timothy A
TA
Ruiter
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. shanta@uga.edu.
Rakesh K
RK
Pathak
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. shanta@uga.edu.
Shanta
S
Dhar
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D016753:Interleukin-10 / Q000097:blood / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000276:immunology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D015850:Interleukin-6; D011108:Polymers; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D001241:Aspirin