Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis.
The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hypertension. Published literature was retrieved from PubMed. Pooled odd's ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effect models. A total of 10 case-control studies containing 3653 cases and 3457 controls were enrolled to this meta-analysis. In a combined analysis, the results showed a significant association between the AGT A-20C polymorphism and risk of essential hypertension (AA vs CC: OR = 0.62, 95%CI = 0.46-0.84; recessive model: OR = 0.66, 95%CI = 0.49-0.88). In the subgroup analysis stratified by race, significant associations were found between the AGT A-20C polymorphism and essential hypertension risk in Asians (AA vs CC: OR = 0.59, 95%CI = 0.43-0.80; recessive model: OR = 0.63, 95%CI = 0.46-0.85). In conclusion, the results of this meta-analysis suggested that the AGT A-20C polymorphism was associated with risk of essential hypertension in Asians.
Department of Cardiovascular Surgery Intensive Care Unit, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangzhou, China.
R
R
Zeng
Department of Anesthesiology, Tianjin First Center Hospital, Tianjin, China.
Q P
QP
Wang
Department of Cardiovascular Surgery Intensive Care Unit, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangzhou, China.
M X
MX
Fang
Department of Cardiovascular Surgery, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangzhou, China.
J
J
Zhuang
Department of Cardiovascular Surgery, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangzhou, China fanrxme@163.com.
R X
RX
Fan
D000808:Angiotensinogen / Q000235:genetics*; D044466:Asian People; D000075222:Essential Hypertension; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D000808:Angiotensinogen