[Acquired A hemophilia and lymphoproliferative diseases: A literature review].
Acquired A haemophilia is a rare but severe autoimmune disease. It is caused by autoantibodies against the coagulation factor VIII. These autoantibodies could have different consequences: no effect, inhibition of factor VIII or factor VIII activity hydrolyzing. In about half of the cases, no cause is associated with the disorder [idiopathic acquired A haemophilia]. But in remaining 50% of the patients, some circumstances could be associated with acquired hemophilia: post-partum, autoimmune disorders, cancer and sometimes malignant blood disorders. The objective of this article was to review the literature about acquired A hemophilia associated with lymphoproliferative diseases.
Unité d'hémostase, hématologie biologique, institut de biologie clinique, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France; Inserm U1096, UFR médecine, 22, boulevard Gambetta, 76183 Rouen cedex, France. Electronic address: veronique.le-cam-duchez@chu-rouen.fr.
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Le Cam-Duchez
D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000150:complications*
Acquired haemophilia; Anti-factor VIII antibodies; Anticorps anti-facteur VIII; Hémopathies lymphoïdes; Hémophilie acquise; Lymphoproliferative diseases; Pathogenesis; Physiopathologie