DARA: a web server for rapid search of structural neighbours using solution small angle X-ray scattering data.
BACKGROUND
Small angle X-ray scattering (SAXS) is an established method for studying biological macromolecules in solution, whereby the experimental scattering patterns relate to the quaternary and tertiary structure of the macromolecule. Here we present DARA, a web-server, that queries over 150 000 scattering profiles pre-computed from the high resolution models of macromolecules and biological assemblies in the Protein Data Bank, to rapidly find nearest neighbours of a given experimental or theoretical SAXS pattern. Identification of the best scattering equivalents provides a straightforward and automated way of structural assessment of macromolecules based on a SAXS profile. DARA results are useful e.g. for fold recognition and finding of biologically active oligomers.


METHODS
http://dara.embl-hamburg.de/.
European Molecular Biology Laboratory, Hamburg Outstation, EMBL c/o DESY, 22607 Hamburg, Germany and.
Alexey G
AG
Kikhney
European Molecular Biology Laboratory, Hamburg Outstation, EMBL c/o DESY, 22607 Hamburg, Germany and.
Alejandro
A
Panjkovich
Bragg Institute, ANSTO, Lucas Heights, 2234 NSW Australia.
Anna V
AV
Sokolova
European Molecular Biology Laboratory, Hamburg Outstation, EMBL c/o DESY, 22607 Hamburg, Germany and.
Dmitri I
DI
Svergun
D030562:Databases, Protein; D020407:Internet; D046911:Macromolecular Substances / Q000737:chemistry*; D053838:Scattering, Small Angle; D012984:Software; D014961:X-Ray Diffraction
D046911:Macromolecular Substances