Transcriptional ontogeny of first trimester human fetal and placental mesenchymal stem cells: Gestational age versus niche.
Early fetal and placental MSCs have translationally-advantageous characteristics compared to later pregnancy MSCs. During the first trimester, the fetus and placenta grow rapidly with divergent developmental requirements, but studies comparing mesenchymal stem cells (MSCs) from different origins have paid little attention to the effect of gestational age over this temporal window. Here we present the transcriptome through first trimester development of MSC isolated from fetal bone marrow (BM) or placental structures. Samples were collected weekly from 8 to 12 weeks. The raw microarray data are available on the ArrayExpress database (www.ebi.ac.uk/arrayexpress) under accession number E-TABM-1224. Additionally, the data have been integrated into the stem cell collaboration platform www.Stemformatics.org. These data provide a valuable resource for developmental biology and stem cell investigation.
The University of Queensland, UQ Centre for Clinical Research, Herston Campus, Herston QLD 4029, Australia.
Jennifer M
JM
Ryan
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane St. Lucia, QLD 4072, Australia ; Eskitis Institute for Cell and Molecular Therapies, National Centre for Adult Stem Cell Research, Griffith University, Brisbane, Australia.
Nicholas
N
Matigian
The University of Queensland, UQ Centre for Clinical Research, Herston Campus, Herston QLD 4029, Australia.
Rebecca A
RA
Pelekanos
The University of Queensland, UQ Centre for Clinical Research, Herston Campus, Herston QLD 4029, Australia.
Samuel
S
Jesuadian
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane St. Lucia, QLD 4072, Australia ; The Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, The University of Glasgow, Scotland G12 8TA, UK.
Christine A
CA
Wells
The University of Queensland, UQ Centre for Clinical Research, Herston Campus, Herston QLD 4029, Australia ; Centre for Advanced Prenatal Care, Royal Brisbane & Women's Hospital, Herston QLD 4029, Australia.
Nicholas M
NM
Fisk
Fetal; First trimester; Gestational age; Mesenchymal stem/stromal cells; Placental