Gold(III) complexes with hydroxyquinoline, aminoquinoline and quinoline ligands: Synthesis, cytotoxicity, DNA and protein binding studies.
In this article, we report on the synthesis and the chemical and biological characterization of novel gold(III) complexes based on hydroxyl- or amino-quinoline ligands that are evaluated as prospective anticancer agents. To gain further insight into their reactivity and possible mode of action, their interactions with model proteins and standard nucleic acid molecules were investigated.
Departamento de Química Inorgánica (Módulo 7), Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain.
Cecilia
C
Martín-Santos
Mass Spectrometry Center (CISM), University of Florence, via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
Elena
E
Michelucci
Laboratory of Metals in Medicine (MET MED), Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
Tiziano
T
Marzo
Laboratory of Metals in Medicine (MET MED), Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
Luigi
L
Messori
Pharmazeutische/Medizinische Chemie, Institut für Pharmazie, Ernst-Moritz-Arndt Universität Greifswald, 17487 Greifswald, Germany.
Piotr
P
Szumlas
Pharmazeutische/Medizinische Chemie, Institut für Pharmazie, Ernst-Moritz-Arndt Universität Greifswald, 17487 Greifswald, Germany.
Patrick J
PJ
Bednarski
Departamento de Química Inorgánica (Módulo 7), Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain.
Rubén
R
Mas-Ballesté
Departamento de Química Inorgánica (Módulo 7), Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain.
Carmen
C
Navarro-Ranninger
Departamento de Química Inorgánica (Módulo 7), Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain. Electronic address: silvia.cabrera@uam.es.
Silvia
S
Cabrera
Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain. Electronic address: jose.aleman@uam.es.
José
J
Alemán
D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry*; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D050607:Organogold Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D011485:Protein Binding; D011804:Quinolines / Q000737:chemistry*
D000970:Antineoplastic Agents; D008024:Ligands; D050607:Organogold Compounds; D011804:Quinolines; D004247:DNA; D003576:Electron Transport Complex IV
Cytochrome c interaction; Gold(III) complexes; Quinoline derivatives