Interleukin 10 gene -1082A/G polymorphism is associated with osteosarcoma risk and poor outcomes in the Chinese population.
Interleukin-10 (IL-10) is a multifunctional cytokine that participates in the development and progression of various malignant tumors. However, data regarding the role of IL-10 polymorphisms in osteosarcoma development are not available. A case-control study was conducted in 260 patients with osteosarcoma and 260 healthy controls to investigate the possible association between IL-10 polymorphisms and the risk of osteosarcoma. Our results indicate the IL-10 -1082A/G (rs1800896) polymorphism is significantly associated with an increased risk of osteosarcoma in all genetic models (AG vs. AA, odds ratio (OR) = 1.56; 95 % confidence interval (CI) = 1.28-2.32, P = 0.017; GG vs. AA, OR = 1.62, 95 % CI 1.24-2.61, P = 0.013; AG + GG vs. CC, OR = 1.76, 95 % CI = 1.31-3.01, P = 0.019). However, the genotype and allele frequencies of IL-10 -819C/T (rs1800871) and -592A/C (rs1800872) polymorphisms in osteosarcoma patients did not significantly differ from controls. Further analyses revealed that the IL-10 -1082A/G (rs1800896) genotypes were associated with advanced tumor stages and metastasis in osteosarcoma patients. Additionally, a statistically significant association between the IL-10 -1082A/G (rs1800896) genotype and poor survival in osteosarcoma patients was observed. Our results demonstrate that the IL-10 -1082A/G (rs1800896) genotype is associated with an increased susceptibility and worse outcome for osteosarcoma patients in the Chinese Han population.
Department of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, 4# Chongshandong Road, Shenyang, 110000, Liaoning Province, China.
Yan
Y
Cui
Department of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, 4# Chongshandong Road, Shenyang, 110000, Liaoning Province, China.
Jia-Jun
JJ
Zhu
Department of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, 4# Chongshandong Road, Shenyang, 110000, Liaoning Province, China.
Cheng-Bin
CB
Ma
Department of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, 4# Chongshandong Road, Shenyang, 110000, Liaoning Province, China.
Kai
K
Cui
Department of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, 4# Chongshandong Road, Shenyang, 110000, Liaoning Province, China.
Feng
F
Wang
Department of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, 4# Chongshandong Road, Shenyang, 110000, Liaoning Province, China.
Sheng-Hui
SH
Ni
Department of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, 4# Chongshandong Road, Shenyang, 110000, Liaoning Province, China. zhangzhiyu_1972@163.com.
Zhi-Yu
ZY
Zhang
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D012516:Osteosarcoma / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
C508609:IL10 protein, human; D016753:Interleukin-10
IL-10; Osteosarcoma; Outcome; Single-nucleotide polymorphism; Susceptibility