Loss of CD47 Makes Dendritic Cells See Red.
Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation.
Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, the Netherlands. Electronic address: t.k.vandenberg@sanquin.nl.
Timo K
TK
van den Berg
Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, the Netherlands. Electronic address: r.vanbruggen@sanquin.nl.
Robin
R
van Bruggen
D056704:Adaptive Immunity; D000818:Animals; D051928:CD47 Antigen / Q000097:blood*; D003713:Dendritic Cells / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology*; D017634:Self Tolerance / Q000276:immunology*; D013154:Spleen / Q000276:immunology*
D051928:CD47 Antigen; D011971:Receptors, Immunologic