Silver(I)-Catalyzed Enantioselective Desymmetrization of Cyclopentenediones: Access to Highly Functionalized Bicyclic Pyrrolidines.
A highly enantioselective desymmetrization of prochiral cyclopentenediones via Ag(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylide has been developed successfully. The methodology performs well over a broad scope of substrates, which provides facile access to a series of highly functionalized bicyclic pyrrolidine/cyclopentane derivatives in good to high yields with excellent stereoselectivities.
College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072 China.
Hua-Chao
HC
Liu
College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072 China.
Kang
K
Liu
College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072 China.
Zhi-Yong
ZY
Xue
College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072 China.
Zhao-Lin
ZL
He
College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072 China.|State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin 300071, China.
Chun-Jiang
CJ
Wang