Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats: An Experimental Study With Histopathological Evaluations.
Rosa canina L. (Rosaceae) has been traditionally used as a medicinal plant. This study was undertaken to evaluate the antidiabetic and antihyperlipidemic effects of Rosa canina fruit extract in streptozotocin induced diabetic rats. The results showed oral administration of Rosa canina fruit extract significantly ameliorated the high levels of blood glucose compared with the control group. Serum triglyceride levels significantly decreased by the administration of Rosa canina extract compared with control. Histopathological examinations showed that the Rosa canina extract improved islets necrotic and regenerated pancreatic islet cells. Rosa canina extract has the antihyperglycemic and antihyperlipidemic effects in streptozotocin-induced diabetic rats.
Kashan University of Medical Sciences, Kashan, I.R.Iran.
Mohsen
M
Taghizadeh
Fasa University of Medical Sciences, Fasa, Iran rashidi_al@yahoo.com.
Ali Akbar
AA
Rashidi
Kashan University of Medical Sciences, Kashan, I.R.Iran rashidi_al@yahoo.com.
Ali Akbar
AA
Taherian
Kashan University of Medical Sciences, Kashan, I.R.Iran.
Zarichehr
Z
Vakili
Kashan University of Medical Sciences, Kashan, I.R.Iran.
Mohammad
M
Sajad Sajadian
Kashan University of Medical Sciences, Kashan, I.R.Iran.
Mostafa
M
Ghardashi
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005638:Fruit / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027826:Rosa / Q000737:chemistry*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts
diabetes mellitus; hyperglycemia; lipids; medicinal plants