An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels.
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials. Voltage-gated sodium channels expression, localisation and function are regulated by a range of transcriptional and post-translational mechanisms. Here, we review our understanding of regulation of brain voltage-gated sodium channels, in particular SCN1A (NaV1.1), SCN2A (NaV1.2), SCN3A (NaV1.3) and SCN8A (NaV1.6), by transcription factors, by alternative splicing, and by post-translational modifications. Our focus is strongly centred on recent research lines, and newly generated knowledge.
School of Biological, Biomedical and Environmental Sciences, University of Hull, Hardy Building Cottingham Road, Hull, HU6 7RX, UK.
Donatus O
DO
Onwuli
School of Biological, Biomedical and Environmental Sciences, University of Hull, Hardy Building Cottingham Road, Hull, HU6 7RX, UK. p.beltran-alvarez@hull.ac.uk.
Pedro
P
Beltran-Alvarez
D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic; D061566:Voltage-Gated Sodium Channels / Q000235:genetics* / Q000378:metabolism
D061566:Voltage-Gated Sodium Channels
Alternative splicing; Post-translational modification; Regulation; Transcription factor; Voltage-gated sodium channel