Does adenosine deaminase activity play a role in the early diagnosis of ectopic pregnancy?
Early diagnosis of ectopic pregnancy (EP) is important due to life-threatening consequences in the first trimester of pregnancy. In this study we aimed to investigate the role of adenosine deaminase (ADA) activity in the prediction of EP. Forty-one patients with unruptured ectopic pregnancy comprised the case group and forty-two first trimester pregnant women with shown foetal heart beating in ultrasound comprised the control group. The mean ADA level in EP (10.9 ± 3.0 IU/L) was higher than that in control group (9.2 ± 3.6 IU/L) (p = 0.018). Receiver operating characteristics or ROC curve identified ADA value of 10.95 IU/L as optimal threshold for the prediction of EP with 56% sensitivity and 67% specificity. High ADA levels are valuable in the early diagnosis of EP. However more comprehensive studies are required.
a Department of Gynecology and Obstetrics , Ankara Education and Research Hospital , Ankara , Turkey.
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Turkmen
a Department of Gynecology and Obstetrics , Ankara Education and Research Hospital , Ankara , Turkey.
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Karçaaltıncaba
a Department of Gynecology and Obstetrics , Ankara Education and Research Hospital , Ankara , Turkey.|b Department of Gynecology and Obstetrics , Bülent Ecevit University , Zonguldak , Turkey.
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Isık
c Department of Biochemistry , Ankara Education and Research Hospital , Ankara , Turkey.
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Fidancı
c Department of Biochemistry , Ankara Education and Research Hospital , Ankara , Turkey.
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Kaayalp
d Department of Gynecology and Obstetrics , Zekai Tahir Burak Women's Health and Research Hospital , Ankara , Turkey.
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Tımur
a Department of Gynecology and Obstetrics , Ankara Education and Research Hospital , Ankara , Turkey.
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Batıoglu
D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood / Q000175:diagnosis*; D055815:Young Adult
D015415:Biomarkers; D000243:Adenosine Deaminase
Adenosine deaminase; ectopic pregnancy; pregnancy complications