Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914).
We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, in 2013. The MIC50, MIC90, and MIC range for ETX0914 were 0.03 μg/ml, 0.06 μg/ml, and ≤0.002 to 0.125 μg/ml, respectively. All isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. Of the isolates, 46.5% were penicillinase-producing N. gonorrhoeae (PPNG), 36% were tetracycline-resistant N. gonorrhoeae (TRNG), and 13% (24 isolates) had an MIC of 0.125 μg/ml for ceftriaxone. ETX0914 may be an effective treatment option for gonorrhea.
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Xiao-Hong
XH
Su
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China wangbx@ncstdlc.org.
Bao-Xi
BX
Wang
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Wen-Jing
WJ
Le
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Yu-Rong
YR
Liu
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Chuan
C
Wan
National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Sai
S
Li
Macrolide Pharmaceuticals, Lexington, Massachusetts, USA.
Richard A
RA
Alm
Entasis Therapeutics, Waltham, Massachusetts, USA.
John P
JP
Mueller
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Peter A
PA
Rice
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D001463:Barbiturates / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D027081:DNA Gyrase / Q000235:genetics* / Q000378:metabolism; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000235:genetics; D015870:Gene Expression; D006069:Gonorrhea / Q000382:microbiology; D006801:Humans; D007555:Isoxazoles; D008297:Male; D008826:Microbial Sensitivity Tests; D009025:Morpholines; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D023303:Oxazolidinones; D013141:Spiro Compounds / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors / Q000494:pharmacology*; D014526:Urethritis / Q000382:microbiology
D000900:Anti-Bacterial Agents; D001463:Barbiturates; D007555:Isoxazoles; D009025:Morpholines; D023303:Oxazolidinones; D013141:Spiro Compounds; D059005:Topoisomerase II Inhibitors; D002939:Ciprofloxacin; D002443:Ceftriaxone; D017963:Azithromycin; D027081:DNA Gyrase; D013752:Tetracycline; C000599190:zoliflodacin