Volume depletion provided by blood donation alters twist mechanics of the heart: Preload dependency of left ventricular torsion.
OBJECTIVE
The crucial role of twisting motion on both left ventricular (LV) contraction and relaxation has been clearly identified. However, the reports studying the association between LV torsion and loading conditions have revealed conflicting outcomes. Previously normal saline infusion was shown to increase LV rotation. Our aim was to test this phenomenon after volume depletion in healthy volunteer blood donors.


METHODS
A total of 26 healthy male volunteers were included in the study. LV end-diastolic and end-systolic diameter, LV ejection fraction, LV diastolic parameters, LV apical and basal rotation and peak systolic LV torsion were measured by speckle-tracking echocardiography before and after 450 mL blood donation.


RESULTS
Blood donation led to a significant decrease in end-diastolic LV internal diameter (48.7 ± 0.4 versus 46.4 ± 0.4 mm; p < 0.001) and cardiac output (6.2 ± 1.0 versus 5.1 ± 0.7 L/min; p < 0.001). There was a significant decrease in the magnitude of peak systolic apical rotation (4.4 ± 1.9° versus 2.9 ± 1.5°; p < 0.001) but no change in basal rotation (2.6 ± 1.4° versus 2.7 ± 1.6°; p = 0.81). Peak systolic LV Torsion decreased after blood donation (6.9 ± 1.9° versus 5.7 ± 2.1°; p = 0.028).


CONCLUSIONS
LV apical rotation and peak systolic LV torsion seem to be preload dependent. Preload reduction provided by 450-mL blood donation decreased LV torsion in healthy male volunteers. Volume dynamics should be taken into account in the evaluation of LV torsion.
a Department of Cardiology , Giresun State Hospital , Giresun , Turkey ;
Uğur
U
Saygısunar
b Department of Cardiology, Faculty of Medicine , Sakarya University , Sakarya , Turkey ;
Harun
H
Kılıç
c Department of Cardiology , Keçiören Education and Research Hospital , Ankara , Turkey ;
Mehmet
M
Aytürk
d Department of Cardiology, Faculty of Medicine , Giresun University , Giresun , Turkey ;
Ahmet
A
Karagöz
e Department of Cardiology, Faculty of Medicine , Sakarya University , Sakarya , Turkey ;
Mustafa
M
Gökhan Vural
e Department of Cardiology, Faculty of Medicine , Sakarya University , Sakarya , Turkey ;
Murat
M
Aksoy
f Department of Cardiology , Dışkapı Yıldırım Beyazıt Education and Research Hospital , Ankara , Turkey.
Ekrem
E
Yeter
D000222:Adaptation, Physiological; D000328:Adult; D001696:Biomechanical Phenomena; D001782:Blood Donors; D001810:Blood Volume; D003971:Diastole; D018619:Echocardiography, Doppler, Pulsed; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D009200:Myocardial Contraction; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors; D054159:Torsion, Mechanical; D016277:Ventricular Function, Left
Left ventricular torsion; blood donation; preload