5-Arylaminouracil Derivatives as Potential Dual-Action Agents.
Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5-40 μg/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without causing toxicity in vitro (MT-4 cells) and ex vivo (human tonsillar tissue).
Engelhardt Institute of Molecular Biology, Vavilova Str., 32, Moscow, 119991, Russia.
E S
ES
Matyugina
Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd, 400131, Russia.
M S
MS
Novikov
Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd, 400131, Russia.
D A
DA
Babkov
Engelhardt Institute of Molecular Biology, Vavilova Str., 32, Moscow, 119991, Russia.
V T
VT
Valuev-Elliston
Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
C
C
Vanpouille
Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
S
S
Zicari
Department of Life and Environmental Sciences, University of Cagliari, Monserrato, 09042, Italy.
A
A
Corona
Department of Life and Environmental Sciences, University of Cagliari, Monserrato, 09042, Italy.
E
E
Tramontano
Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
L B
LB
Margolis
Engelhardt Institute of Molecular Biology, Vavilova Str., 32, Moscow, 119991, Russia.
A L
AL
Khandazhinskaya
Engelhardt Institute of Molecular Biology, Vavilova Str., 32, Moscow, 119991, Russia.
S N
SN
Kochetkov
5-(phenylamino)uracil derivatives; 5’-norcarbocyclic nucleoside analogs; HIV and Mycobacterium tuberculosis co-infection; dual action