Three new compounds from Cinnamomum cassia.
Three new compounds, including two new diterpenoids, named epianhydrocinnzeylanol (1) and cinnacasiol H (2), and one hydroxylasiodiplodin, (3R,4S,6R)-4,6-dihydroxy-de-O-methyllasiodiplodin (3), together with five known diterpenoids (4-8) and two known phenolic glycosides (9-10) were isolated from the barks of Cinnamomum cassia. Their structures were elucidated by extensive spectroscopic analysis and comparison of the chemical shift values with those of related known compounds. The anti-inflammatory activities of the isolates were evaluated on nitric oxide production in lipopolysaccharide-induced BV-2 microglial cells and the compounds showed weak inhibition activities.
a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Beijing 100191 , China.
Shan
S
He
a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Beijing 100191 , China.
Yong
Y
Jiang
a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Beijing 100191 , China.
Peng-Fei
PF
Tu
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032904:Cinnamomum aromaticum / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry; D008070:Lipopolysaccharides / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008516:Medicine, Chinese Traditional; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D013237:Stereoisomerism
C000608884:(3R,4S,6R)-4,6-dihydroxy-de-O-methyllasiodiplodin; D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D006027:Glycosides; D008070:Lipopolysaccharides; D018942:Macrolides; C000608883:cinnacasiol H; C000608882:epianhydrocinnzeylanol; D009569:Nitric Oxide
Cinnamomum cassia; anti-inflammatory activity; chemical constituents; diterpenoids; hydroxylasiodiplodin