Process of Hypertrophic Scar Formation: Expression of Eukaryotic Initiation Factor 6.
BACKGROUND
Hypertrophic scar is one of the most common complications and often causes the disfigurement or deformity in burn or trauma patients. Therapeutic methods on hypertrophic scar treatment have limitations due to the poor understanding of mechanisms of hypertrophic scar formation. To throw light on the molecular mechanism of hypertrophic scar formation will definitely improve the outcome of the treatment. This study aimed to illustrate the negative role of eukaryotic initiation factor 6 (eIF6) in the process of human hypertrophic scar formation, and provide a possible indicator of hypertrophic scar treatment and a potential target molecule for hypertrophic scar.


METHODS
In the present study, we investigated the protein expression of eIF6 in the human hypertrophic scar of different periods by immunohistochemistry and Western blot analysis.


RESULTS
In the hypertrophic scar tissue, eIF6 expression was significantly decreased and absent in the basal layer of epidermis in the early period, and increased slowly and began to appear in the basal layer of epidermis by the scar formation time.


CONCLUSIONS
This study confirmed that eIF6 expression was significantly related to the development of hypertrophic scar, and the eIF6 may be a target molecule for hypertrophic scar control or could be an indicator of the outcomes for other treatment modalities.
Qing-Qing
QQ
Yang
Si-Si
SS
Yang
Jiang-Lin
JL
Tan
Gao-Xing
GX
Luo
Wei-Feng
WF
He
Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, The Third Military Medical University, Chongqing 400038; Chongqing Key Laboratory for Disease Proteomics, The Third Military Medical University, Chongqing 400038, China.
Jun
J
Wu
D000328:Adult; D015153:Blotting, Western; D017439:Cicatrix, Hypertrophic / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010448:Peptide Initiation Factors / Q000378:metabolism*; D011247:Pregnancy; D012189:Retrospective Studies; D055815:Young Adult
D010448:Peptide Initiation Factors; C021019:eIF-6