Association of single nucleotide polymorphisms of ABCB1, OPRM1 and COMT with pain perception in cancer patients.
Pain perception is influenced by multiple factors. The single nucleotide polymorphisms (SNPs) of some genes were found associated with pain perception. This study aimed to examine the association of the genotypes of ABCB1 C3435T, OPRM1 A118G and COMT V108/158M (valine 108/158 methionine) with pain perception in cancer patients. We genotyped 146 cancer pain patients and 139 cancer patients without pain for ABCB1 C3435T (rs1045642), OPRM1 A118G (rs1799971) and COMT V108/158M (rs4680) by the fluorescent dye-terminator cycle sequencing method, and compared the genotype distribution between groups with different pain intensities by chi-square test and pain scores between groups with different genotypes by non-parametric test. The results showed that in these cancer patients, the frequency of variant T allele of ABCB1 C3435T was 40.5%; that of G allele of OPRM1 A118G was 38.5% and that of A allele of COMT V108/158M was 23.3%. No significant difference in the genotype distribution of ABCB1 C3435T (rs1045642) and OPRM1 A118G (rs1799971) was observed between cancer pain group and control group (P=0.364 and 0.578); however, significant difference occurred in the genotype distribution of COMT V108/158M (rs4680) between the two groups (P=0.001). And the difference could not be explained by any other confounding factors. Moreover, we found that the genotypes of COMT V108/158M and ABCB1 C3435T were associated with the intensities of pain in cancer patients. In conclusion, our results indicate that the SNPs of COMT V108/158M and ABCB1 C3435T significantly influence the pain perception in Chinese cancer patients.
Department of Oncology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, 430000, China.
Xu-Shi
XS
Wang
Department of Oncology, Huazhong University of Science and Technology, Wuhan, 430030, China.
Hai-Bin
HB
Song
Department of Oncology, Huazhong University of Science and Technology, Wuhan, 430030, China.
Si
S
Chen
Department of Oncology, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wei
W
Zhang
Department of Oncology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, 430000, China.
Jia-Qi
JQ
Liu
Department of Oncology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, 430000, China.
Chao
C
Huang
Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Hao-Ran
HR
Wang
Department of Oncology, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yuan
Y
Chen
Department of Oncology, Huazhong University of Science and Technology, Wuhan, 430030, China. qianchu@tjh.tjmu.edu.cn.
Qian
Q
Chu
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001943:Breast Neoplasms / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D015870:Gene Expression; D005787:Gene Frequency; D005833:Genital Neoplasms, Female / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D005834:Genital Neoplasms, Male / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D010147:Pain Measurement; D058748:Pain Perception; D020641:Polymorphism, Single Nucleotide; D017450:Receptors, Opioid, mu / Q000235:genetics*
C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
ABCB1; COMT; OPRM1; cancer pain; pain perception; single nucleotide polymorphisms (SNPs)