Targeted anticancer drug delivery through anthracycline antibiotic bearing functionalized quantum dots.
We herein first report a method for the synthesis of chitosan (CHI)-folate conjugated colloidal ZnO-Mn(+2) quantum dots (QDs) bearing doxorubicin through chemical method (DOX/FA-CHI-QDs) for cancer therapy as well imaging purpose. The entrapment efficiency was determined to be 99.98 ± 0.012% (DOX/FA-CHI-QDs) and 92.0 ± 2.62% (DOX-QDs). The developed DOX/FA-CHI-QDs formulations depict the sustained release pattern at the lysosomal pH (pH 5.0). The DOX/FA-CHI-QDs showed enhanced cytotoxicity, cellular uptake and were most preferentially taken up by the cancerous cells via receptor-mediated endocytosis (RME) mechanism. Hence, the QD-based formulation is capable of targeting drug delivery and imaging the delivery process.
a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India.
Neha
N
Bajwa
a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India.
Neelesh
N
Kumar Mehra
a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India.
Keerti
K
Jain
a Pharmaceutical Nanotechnology Research Laboratory , ISF College of Pharmacy , Moga , Punjab , India.
Narendra
N
Kumar Jain
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D045663:Quantum Dots / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin
Chitosan; doxorubicin HCL; folic acid; imaging; quantum dots; targeting