Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson's disease.
Parkinson's disease (PD) impairs the control of movement and cognition, including the planning of action and its consequences. This provides the opportunity to study the dopaminergic influences on the perception and awareness of action. Here we examined the perception of the outcome of a goal-directed action made by medicated patients with PD. A visuomotor task probed the integration of sensorimotor signals with the positive expectations of outcomes (Self priors), which in healthy adults bias perception toward success in proportion to trait optimism. We tested the hypotheses that (i) the priors on the perception of the consequences of one's own actions differ between patients and age- and sex-matched controls, and (ii) that these priors are modulated by the levodopa dose equivalent (LDEs) in patients. There was no overall difference between patients and controls in the perceptual priors used. However, the precision of patient priors was inversely related to their LDE. Patients with high LDE showed more accurate priors, representing predictions that were closer to the true distribution of performance. Such accuracy has previously been demonstrated when observing the actions of others, suggesting abnormal awareness of action in these patients. These results confirm a link between dopamine and the positive expectation of the outcome of one's own actions, and may have implications for the management of PD.
Department of Clinical Neurosciences, University of Cambridge Cambridge, UK ; Medical Research Council Cognition and Brain Sciences Unit Cambridge, UK.
Noham
N
Wolpe
Department of Clinical Neurosciences, University of Cambridge Cambridge, UK ; Medical Research Council Cognition and Brain Sciences Unit Cambridge, UK.
Cristina
C
Nombela
Department of Clinical Neurosciences, University of Cambridge Cambridge, UK ; Medical Research Council Cognition and Brain Sciences Unit Cambridge, UK ; Behavioural and Clinical Neuroscience Institute, University of Cambridge Cambridge, UK.
James B
JB
Rowe
Bayesian; Parkinson’s disease; agency; dopamine; inverted U-shaped function; placebo; positive expectation; voluntary action