Rh-Catalyzed Asymmetric Hydrogenation of Cyclic α-Dehydroamino Ketones.
Catalyzed by a rhodium complex of P-stereogenic diphosphine trichickenfootphos, five-membered cyclic α-dehydroamino ketones bearing endocyclic acyl and endocyclic vinyl groups were hydrogenated to give chiral α-amino ketones with quantitative conversions and excellent enantioselectivities.
School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, P. R. China.
Zhenfeng
Z
Zhang
School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, P. R. China.
Qiupeng
Q
Hu
School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, P. R. China.
Yingjie
Y
Wang
School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, P. R. China.
Jianzhong
J
Chen
School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, P. R. China.
Wanbin
W
Zhang