Incisional Recurrences After Endometrial Cancer Surgery.
OBJECTIVE
The aim of the present study was to estimate the incisional recurrence (IR) rate after endometrial cancer (EC) staging surgery and analyze characteristics of affected patients.


METHODS
We retrospectively searched for patients with EC at 2 institutions and analyzed the occurrence of IR after open, laparoscopic, or robotic surgery. Additionally, a review of the literature was performed.


RESULTS
Out of 2,636 patients with EC, 1,732 (65.7%), 461 (17.5%), and 443 (16.8%) had open, laparoscopic, and robotic surgery, respectively. Only 3 patients (0.11%) had IR, all after open surgery. Additionally, 38 cases of IR were identified from the literature. Patients with non-isolated IR had worse overall survival than patients with isolated IR (p=0.04). Among this latter group, combined treatments may be associated with improved survival outcome.


CONCLUSIONS
IR after EC surgery is rare and may occur after minimally-invasive or open operations. Combination of local and systemic treatments may provide favorable outcomes for patients with isolated IR.
Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, U.S.A.
Giorgio
G
Bogani
Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, U.S.A.
Sean C
SC
Dowdy
Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, U.S.A.
William A
WA
Cliby
Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, U.S.A.
Bobbie S
BS
Gostout
Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, U.S.A.
Sanjeev
S
Kumar
Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Varese, Italy.
Fabio
F
Ghezzi
Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, U.S.A.
Francesco
F
Multinu
Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, U.S.A. mariani.andrea@mayo.edu.
Andrea
A
Mariani
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000209:etiology*; D009367:Neoplasm Staging; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
Endometrial cancer; incisional recurrence; laparoscopy; open surgery; port site metastases