The hyper-fluorescent transitional bands in ultra-late phase of indocyanine green angiography in chronic central serous chorioretinopathy.
OBJECTIVE
Chronic central serous chorioretinopathy (CSCR) is regarded as a type of severe diffuse retinal pigment epitheliopathy. There is an atrophic tract at level of retinal pigment epithelium (RPE) due to hyper-permeability of choroidal vessels, along with photoreceptor (PR) atrophy. Indocyanine green angiography (ICGA) is considered a gold standard for diagnosis. The purpose of this work is to investigate the hyper-fluorescent transitional bands (HFTB) between hypo-fluorescent and normal regions of the retina in the ultra-late phase of ICGA in CSCR.


METHODS
26 chronic CSCR eyes and 12 relative normal eyes received spectral domain optical coherence tomography (SD-OCT), and ICGA at the 24th hour after indocyanine green (ICG) intravenous injection.


RESULTS
In the ultra-late phase, images showed homogenous fluorescence in all normal eyes. On the contrary, geographical hypofluorescent lesions with atrophy of RPE was noted in 26 chronic CSCR eyes. Moreover, HFTB with intact RPE and disrupted PR was detected in 20 out of 26 chronic CSCR eyes (76.9%).


CONCLUSIONS
The HFTB may indicate the early damage in chronic CSCR. Ultra-late ICGA can monitor not only metabolic status by endogenous melanin, but also membrane function in RPE by exogenous ICG molecule.
Department of Ophthalmology, First Hospital of China Medical University, Shenyang, China.
Rui
R
Hua
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510.
Kai
K
Yao
Department of Ophthalmology, Shenyang The Fourth Hospital of People, Shenyang, China.
Fan
F
Xia
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510.
Jun
J
Li
Ophthalmology and optometry center, First Hospital of China Medical University, Shenyang, China.
Lei
L
Guo
Department of Ophthalmology, Hebei Provincial Eye Hospital, Xingtai, China.
Guoxing
G
Yang
Department of Ophthalmology, Shenyang The Fourth Hospital of People, Shenyang, China.
Jun
J
Tao
D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000000981:diagnostic imaging*; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D061848:Optical Imaging / Q000379:methods*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods
D005456:Fluorescent Dyes; D007208:Indocyanine Green
chronic central serous chorioretinopathy; hyper-fluorescent transitional bands; indocyanine green angiography; spectral domain optical coherence tomography; ultra-late phase