Magnesium Corrosion Triggered Spontaneous Generation of H2O2 on Oxidized Titanium for Promoting Angiogenesis.
Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H2O2 without any external light or voltage. The corrosion of Mg transfers electrons to Au-decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H2O2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H2O2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated.
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).
Jimin
J
Park
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).
Ping
P
Du
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).|Korea University of Science and Technology, Daejeon 34113 (South Korea).
Jin-Kyung
JK
Jeon
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).
Gun Hyuk
GH
Jang
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).
Mintai Peter
MP
Hwang
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).
Hyung-Seop
HS
Han
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).|Korea University of Science and Technology, Daejeon 34113 (South Korea).
Kwideok
K
Park
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).|Korea University of Science and Technology, Daejeon 34113 (South Korea).
Kwan Hyi
KH
Lee
School of Advanced Materials Engineering, Kookmin University, Seoul 136-702 (South Korea).
Jee-Wook
JW
Lee
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).|Korea University of Science and Technology, Daejeon 34113 (South Korea).
Hojeong
H
Jeon
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).|Korea University of Science and Technology, Daejeon 34113 (South Korea).
Yu-Chan
YC
Kim
Department of Orthopedic Surgery, School of Medicine, Korea University, Seoul (South Korea).
Jong Woong
JW
Park
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea).|Korea University of Science and Technology, Daejeon 34113 (South Korea).
Hyun-Kwang
HK
Seok
Center for Biomaterials, Korea Institute of Science & Technology, Seoul 136-650 (South Korea). omr2da@kist.re.kr.
Myoung-Ryul
MR
Ok
D043925:Angiogenesis Inducing Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D055664:Electrochemical Techniques; D006861:Hydrogen Peroxide / Q000138:chemical synthesis* / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D010084:Oxidation-Reduction; D010316:Particle Size; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
D043925:Angiogenesis Inducing Agents; D001672:Biocompatible Materials; D006861:Hydrogen Peroxide; D014025:Titanium; D008274:Magnesium
angiogenesis; catalysis; corrosion; magnesium; oxygen reduction reaction