Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese.
OBJECTIVE
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Although idiopathic PD accounts for most of the cases, several genetic mutations have been found to cause PD. Mutations in the eukaryotic translation initiation factor 4-γ, 1 (EIF4G1) gene have been identified since 2011, which were reported to be associated with PD among Caucasians in subsequent research. However, this observation was not consistent. The contribution to other ethnic groups remains limited, with < 1% of sporadic cases. We conducted a case-control study to analyze if EIF4G1 is a risk factor for PD patients in Taiwan.


METHODS
There were 595 PD patients and 600 controls without neurological diseases enrolled in this study. Four reported mutations-A502V (c.1505C>T), G686C (c.2056 G>T), R1197W (c.3589C>T), and R1205H (c.3614G>A)-were analyzed.


RESULTS
There were no mutations found in either PD patients or controls.


CONCLUSIONS
This study indicates that the EIF4G1 mutation is rare in Taiwan, which is consistent with other reports from Asia. Ethnicity could have a great influence on EIF4G1 in PD. Further large scale studies are warranted to evaluate the association of PD and EIF4G1 gene.
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan.
Yi Ching
YC
Weng
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan.
Chiung Mei
CM
Chen
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan.
Yi Chun
YC
Chen
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan.
Hon Chung
HC
Fung
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan.
Chia Wen
CW
Chang
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan.
Kuo Hsuan
KH
Chang
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan. Electronic address: yihruwu@adm.cgmh.org.tw.
Yih Ru
YR
Wu
D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D039603:Eukaryotic Initiation Factor-4G / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D013624:Taiwan
C113920:EIF4G1 protein, human; D039603:Eukaryotic Initiation Factor-4G
Parkinson's disease; eukaryotic translation initiation factor 4-γ, 1; mutations