[THE EFFECT OF PLANT EXTRACTS ON THE CYCLOPHOSPHAMIDE INDUCTION OF MICRONUCLEUS IN RED BLOOD CELLS OF OUTBRED WHITE MICE].
Antimutagenic properties flavonoids extracts of the three plants Gratiola officinalis L., Helichrysum arenarium L., anthocyanin forms Zea mays L. were investigated. Analysis was performed by counting the micronucleus in peripheral blood erythrocytes outbred white mice; the mutagen was cyclophosphamide. Selected extracts reduce the number of micronucleus. Gratiola officinalis L. extract reduces the mutagenic action of cyclo- phosphamide at a dose of 200 mg/kg, Helichrysum arenarium L. extract--at doses of 100 and 200 mg/kg (maximum protective effect was observed at a dose of 200 mg/kg), anthocyanin forms Zea mays L. extract at doses of 50, 100 and 200 mg/kg (a dose of 50 mg/kg--maximum antimutagenic effect).
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Durnova
M N
MN
Kurchatova
D000818:Animals; D000872:Anthocyanins / Q000737:chemistry / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000494:pharmacology; D036562:Helichrysum / Q000737:chemistry; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced / Q000187:drug effects*; D009153:Mutagens / Q000009:adverse effects* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D003313:Zea mays / Q000737:chemistry
D000872:Anthocyanins; D016587:Antimutagenic Agents; D009153:Mutagens; D010936:Plant Extracts; D003520:Cyclophosphamide