Self-assembly of the anti-fungal polyene amphotericin B into giant helically-twisted nanotapes.
The amphiphilic polyene amphotericin B, a powerful treatment for systemic fungal infections, is shown to exhibit a critical aggregation concentration, and to form giant helically-twisted nanostructures via self-assembly in basic aqueous solution.
School of Chemistry, Pharmacy and Food Biosciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AD, UK. i.w.hamley@reading.ac.uk.
Ian William
IW
Hamley
School of Chemistry, Pharmacy and Food Biosciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AD, UK. i.w.hamley@reading.ac.uk.
Steven
S
Kirkham
School of Chemistry, Pharmacy and Food Biosciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AD, UK. i.w.hamley@reading.ac.uk.
Radoslaw M
RM
Kowalczyk
School of Chemistry, Pharmacy and Food Biosciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AD, UK. i.w.hamley@reading.ac.uk.
Valeria
V
Castelletto
Dept. of Applied Physics, Aalto University School of Science, P. O. Box 15100, FI-00076, Finland.
Mehedi
M
Reza
Dept. of Applied Physics, Aalto University School of Science, P. O. Box 15100, FI-00076, Finland.
Janne
J
Ruokolainen
D000666:Amphotericin B / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D002942:Circular Dichroism; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D046911:Macromolecular Substances / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D013237:Stereoisomerism; D014961:X-Ray Diffraction
D000935:Antifungal Agents; D046911:Macromolecular Substances; D000666:Amphotericin B