The protective role of the opioid antagonist LY255582 in the management of high fat diet-induced obesity in adult male albino rats.
OBJECTIVE
The involvement of the opioid system in energy balance has been known for several decades but many questions remain unanswered. Therefore, this study was designed to investigate the effect of the non-selective opioid receptor antagonist (LY255582) on high fat diet (HFD)-induced obesity.


METHODS
Twenty-four adult male albino rats were divided into 4 groups: Control, HFD non-treated, HFD+LY255582 treated during the first 4 weeks and Obese-LY255582- treated groups during the following 4 weeks after the induction of obesity. LY255582 (0.31 mg/kg, s.c.) was administrated daily with HFD feeding. Blood samples were collected for measurement of lipid profile, glucose, insulin, and leptin. Body weight, body mass index (BMI), and food intake were also measured.


RESULTS
Consumption of HFD resulted in a significant increase in body weight, body mass index (BMI), glucose, insulin, leptin levels, and induced a state of dyslipideamia. Opioid antagonist LY255582 administration with HFD decreased food intake, body weight and BMI, in addition to the improvement of HFD related metabolic abnormalities (dyslipidemia and insulin resistance) during the dynamic phase of obesity development than in animals with already developed dietary obesity.


CONCLUSIONS
The use of opioid antagonist may be a promising approach in treatment of HFD-induced obesity.
I Y
IY
Ibrahim
H M
HM
Ibrahim
N M
NM
Aziz
D M
DM
Rahman
D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D015992:Body Mass Index; D003510:Cyclohexanes / Q000494:pharmacology*; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009765:Obesity / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D010880:Piperidines / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D019440:Anti-Obesity Agents; D015415:Biomarkers; D001786:Blood Glucose; D003510:Cyclohexanes; D007328:Insulin; D020738:Leptin; D008055:Lipids; D009292:Narcotic Antagonists; D010880:Piperidines; D011957:Receptors, Opioid; C070736:LY 243670
glucose; high fat diet; insulin; leptin; obesity; opioid receptors.