[Effect of Natural Killer Cell Infiltration on the Growth of Breast Cancer Patient-Derived Tumor Xenografts].
Natural killer (NK) cells, a component of the innate immunity, play important roles in tumor suppression. In this study, three human breast cancer patient-derived tumor xenografts (PDXs), established by the transplantation of surgical specimens, were passaged in immunodeficient NOD/SCID mice or NSG mice, that further lacks NK cell activity. The intensity of the relative growth suppression between NOD/SCID and NSG mice was clearly different depending on the PDX lines, and it was associated with the intensities of the CD49b-positive NK cell infiltration in the PDX tumor tissues. However, no obvious association was observed between the mRNA expression levels of the NK cell ligands in the PDX tumor cells and the intensity of NK cell infiltration into the PDX tumors. These results suggest that the suppressive effect of NK cells on the growth of breast cancer PDX is highly variable depending on the PDX lines. Further studies are needed to elucidate the molecular mechanism of NK cell infiltration in PDX tumors.
Division of Gastro-Intestinal Surgery, Dept. of Surgery, Kobe University Graduate School of Medicine.
Junko
J
Mukohyama
Yohei
Y
Shimono
Yohei
Y
Funakoshi
Seishi
S
Kono
Kimihiro
K
Yamashita
Toru
T
Mukohara
Shintaro
S
Takao
Hironobu
H
Minami
Yoshihiro
Y
Kakeji
D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008024:Ligands; D051379:Mice; D009368:Neoplasm Transplantation
D008024:Ligands