A rare case of hyperoxaluria presenting with acute liver injury and stone-free kidney injury.
A 49-year-old woman visited the clinic because of acute hepatitis and acute kidney injury with decreased urine output presenting microscopic hematuria and proteinuria. An abdominal computed tomography revealed a localized, hypoattenuated lesion in a hepatic lateral segment, and kidney biopsy showed oxalate crystal deposition with tubular necrosis. In addition, the patient׳s 24-hour urinary excretion of oxalate was increased. Her kidney and liver injury improved after sessions of hemodialysis, and urinary oxalate excretion was normalized. Major mutations in primary hyperoxaluria have not been proven. A full sequencing of target genes may be helpful to diagnose a rare form of primary hyperoxaluria.
Department of Internal Medicine, National Medical Center, Seoul, Korea.
Si-Eun
SE
Kim
Department of Internal Medicine, National Medical Center, Seoul, Korea.
Seon-Jae
SJ
Kim
Department of Internal Medicine, National Medical Center, Seoul, Korea.
Seong Taek
ST
Chu
Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Seung Hee
SH
Yang
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Yon Su
YS
Kim
Division of Nephrology, Department of Internal Medicine, National Medical Center, Seoul, Korea.
Ran-Hui
RH
Cha
Acute kidney injury; Acute liver injury; Oxalate nephropathy