Comparison between procalcitonin, brain natriuretic peptide, and uric acid in children with cardiomyopathy and controls.
OBJECTIVE
This study was performed to determine the level of procalcitonin, Brain Natriuretic Peptide (BNP), and uric acid in children with cardiomyopathy in comparison with controls and the association with echocardiographic findings.


METHODS
The levels of BNP, procalcitonin, and serum uric acid were measured and the amounts of biomarkers compared with echocardiographic findings.


RESULTS
In this study mean age of participants was the same (p=0.321). The majority of echocardiographic indices in left and right heart have different means in case and controls (p<0.05). Means of BNP, procalcitonin, and uric acid were 213.814 ± 309.601, 9.326 ± 3.881, and 6.846 ± 1.814 for case group and 2.76 ± 1.013, 1.851 ± 1.466, and 3.317 ± 0.924 for control (p<0.001), respectively. In the patients group there was relationship of Ross classification with BNP (χ (2) = 15.845, p<0.05) and with age (χ (2) = 8.946, p<0.05). For uric acid and procalcitonin no significant relationships were observed.


CONCLUSIONS
Procalcitonin, uric acid, and BNP had significant relationship with many echocardiographic findings in participants. For patients, procalcitonin did not show correlation. The severity of illness based on the Ross classification showed significant correlation with BNP level and age in patients.
Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran.
Noor Mohammad
NM
Noori
Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran.
Maziar
M
Mahjoubifard
Department of Pediatrics, Faculty of Medicine, Zabol University of Medical Sciences, Zahedan 9816743111, Iran.
Iraj
I
Shahramian
Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran.
Alireza
A
Teimouri
Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.
Alireza
A
Jahangirifard
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007492:Iran; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D020097:Natriuretic Peptide, Brain; D014527:Uric Acid; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide