[Synthesis and Anticancer Activity of Betulonic Acid Imidazolides].
Synthesis of lupane C28-imidazolides, contained 3-oxo-, 3-oximino- and 2-cyano-2,3-seco-4(23)-en-frag ments in cycle A was carried out. The most antitumor activity at. in vitro testing showed 3-oximino-lup- 20(29)-en-28-yl-1H-imidazole-1-carboxylate; which inhibited the growth or induced apoptosis of non-small lung cancer, colon cancer, breast cancer, CNS cancer, ovarian cancer, prostate cancer, leucosis, melanoma cells. In experiments in mice its moderate antitumor activity against grafted breast adenocarcinoma Ca 755 and adenocarcinima of colon was observed.
O B
OB
Kazakova
N I
NI
Medvedeva
T V
TV
Lopatina
G N
GN
Apryshko
R B
RB
Pugacheva
N P
NP
Yavorskaya
I S
IS
Golubeva
G A
GA
Tolstikov
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D008297:Male; D051379:Mice; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy; D014315:Triterpenes / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays; D000094062:Betulinic Acid; D053978:Pentacyclic Triterpenes
D000970:Antineoplastic Agents; D007093:Imidazoles; D009828:Oleanolic Acid; D014315:Triterpenes; C118308:betulonic acid; D000094062:Betulinic Acid; C480546:lupane; D053978:Pentacyclic Triterpenes