Agents in the preclinical development stage for non-small cell lung cancer.
Despite recent advancements in identifying distinct molecular subtypes with driver oncogenes and advances in developing targeted treatments such as epidermal growth factor receptor and anaplastic lymphoma kinase inhibitors, current therapeutic approaches for tumors with no driver mutation have achieved a plateau of effectiveness. Thus, the overall outlook of lung cancer survival for most patients remains dismal. Moreover, the inevitable acquisition of resistance to targeted therapies has prompted significant efforts to develop second-generation inhibitors. In recent years, several agents for targeted therapy of lung cancers are rapidly migrating from bench to bedside and multiple small molecule inhibitors with activity against distinct receptors, genes or molecular pathways have been developed.
a ¹ Division of Medical Oncology, S. G. Moscati Hospital, Avellino, Italy.
Paola Claudia
PC
Sacco
b ² Department of Clinical and Experimental Medicine, Second University of Naples, Napoli, Italy.
Assunta
A
Sgambato
b ² Department of Clinical and Experimental Medicine, Second University of Naples, Napoli, Italy.
Francesca
F
Casaluce
a ¹ Division of Medical Oncology, S. G. Moscati Hospital, Avellino, Italy.
Paolo
P
Maione
a ¹ Division of Medical Oncology, S. G. Moscati Hospital, Avellino, Italy.
Antonio
A
Rossi
c ³ USLL5, Cittadella, Italy.
Giovanni
G
Palazzolo
d 4 Division of Pharmacy, S. G. Moscati Hospital, Avellino, Italy.
Alba
A
Napolitano
a ¹ Division of Medical Oncology, S. G. Moscati Hospital, Avellino, Italy.
Cesare
C
Gridelli
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D058990:Molecular Targeted Therapy; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D013534:Survival
D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors
molecular agents; non-small cell lung cancer; preclinical compounds; targeted therapy