MicroRNAs in Parasitic Helminthiases: Current Status and Future Perspectives.
MicroRNAs (miRNAs) play a variety of roles in diverse biological processes at the post-transcriptional regulatory level. Although numerous miRNAs have been identified in parasitic helminths, we still know little about their biological functions. As molecular signatures that can be stably detectable in serum and plasma, worm-derived miRNAs have shown promise as markers for the early detection of particular helminth infections. In addition, host miRNAs are dysregulated during the development of pathology associated with helminthiases and show potential as therapeutic intervention targets. This review discusses the possible biological roles of helminth miRNAs, the prediction of their specific targets, their application in diagnosis and anti-pathology therapy interventions, and the potential functions of miRNAs in extracellular vesicle cargo, such as exosomes, in helminth-host interplay.
Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Queensland, Australia. Electronic address: Pengfei.Cai@qimrberghofer.edu.au.
Pengfei
P
Cai
Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Queensland, Australia.
Geoffrey N
GN
Gobert
Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Queensland, Australia.
Donald P
DP
McManus
D000818:Animals; D005786:Gene Expression Regulation; D006373:Helminthiasis / Q000175:diagnosis* / Q000628:therapy; D006376:Helminths / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D018510:RNA, Helminth / Q000097:blood* / Q000235:genetics*
D035683:MicroRNAs; D018510:RNA, Helminth
circulating miRNAs; diagnosis; extracellular vesicles; microRNA; parasitic helminth; therapeutic intervention