Aging-related Increase in Rho Kinase Activity in the Nigral Region Is Counteracted by Physical Exercise.
Abnormal activation of the RhoA/Rho kinase (ROCK) pathway plays a pivotal role in neuroinflammatory and pro-oxidative responses, axonal retraction, and apoptosis. We observed increased expression of RhoA, ROCK II, and ROCK activity in the brain of aged rats, particularly in the substantia nigra. Increased ROCK activity may enhance major mechanisms responsible for aging-related neurodegeneration, thus representing a major factor in the vulnerability of dopaminergic neurons to damage. We also observed that physical exercise decreased ROCK activation in aged rats. This suggests that decreased ROCK activation plays an important role in the neuroprotective effects of exercise observed in several previous studies. Furthermore, the present results suggest that ROCK inhibitors may constitute an effective neuroprotective strategy against aging-related risk of dopaminergic degeneration and possibly against other aging-related neurodegenerative processes.
Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, CIMUS. University of Santiago de Compostela, Spain. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Spain.
Ana
A
Muñoz
Faculty of Medicine; Master Program of Physical Education - Universidade Federal do Rio de Janeiro, Brazil.
Clynton L
CL
Corrêa
Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, CIMUS. University of Santiago de Compostela, Spain. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Spain.
Begoña
B
Villar-Cheda
Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, CIMUS. University of Santiago de Compostela, Spain. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Spain.
Maria A
MA
Costa-Besada
Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, CIMUS. University of Santiago de Compostela, Spain. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Spain. joseluis.labandeira@usc.es.
Jose L
JL
Labandeira-Garcia
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015153:Blotting, Western; D059290:Dopaminergic Neurons / Q000201:enzymology; D008297:Male; D000066829:Neuroprotection / Q000502:physiology*; D010805:Physical Conditioning, Animal; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra / Q000201:enzymology*; D054460:rho-Associated Kinases / Q000378:metabolism*
D054460:rho-Associated Kinases
Aged; Neuroinflammation; Neuroprotection; Parkinson; ROCK