Percutaneous nerve field stimulation (PENS) of the occipital region as a possible predictor for occipital nerve stimulation (ONS) responsiveness in refractory headache disorders? A feasibility study.
BACKGROUND
Occipital nerve stimulation (ONS) has been reported to diminish pain levels in intractable chronic headache syndromes of different origin. No reliable objective markers exist to predict ONS responsiveness. This study investigated the predictive value of occipital percutaneous nerve field stimulation (PENS) prior to ONS.


METHODS
This trial included 12 patients (CCH, CM, PTH, CH) with chronic refractory headache syndromes eligible for ONS. Repetitive PENS (3 × /10 days) was performed and the headache severity/frequency monitored over four weeks before ONS implantation. Further assessment of PENS/ONS outcomes were stimulation-related complications, perception/tolerance stimulation threshold, the Migraine Disability Scale (MIDAS) and the Beck Depression Inventory (BDI).


RESULTS
All PENS responders benefited from ONS. Of the seven PENS-nonresponders with VAS 6.1(±1.1), six experienced significant pain relief from ONS after three months and one patient failed the PENS/ONS trial (VAS 3.7 (±1.6)); (95% CI 3.6 to 5.7, p < 0.001). The VAS baseline was 8.4 (±0.5) and decreased significantly (50% reduction in severity/frequency) in five patients after PENS, while seven failed to improve (VAS 4.9 (±1.1); (95% CI 2.5 to 4.5, p < 0.001). BDI baseline (from 22.6 (±4.2) to 10.6 (±5.9) (95% CI 7.4 to 16.6, p < 0.001)) and MIDAS baseline (from 143.9 (±14.5) to 72.8 (±28.7) (95% CI 1.17 to 2.3, p < 0.001)) significantly declined after ONS. No PENS/ONS-related complications occurred.


CONCLUSIONS
Presurgical applied occipital PENS failed to identify ONS responders sufficiently according to our study protocol, thus requiring further specific investigations to determine its predictive usefulness.
Division of Functional Neurosurgery, Stereotaxy and Neuromodulation, Department of Neurosurgery, University of Bonn Medical Center, Germany Thomas.Kinfe@ukb.uni-bonn.de.
T M
TM
Kinfe
Department of Neurosurgery, University Hospital, RFW University, Germany.
B
B
Pintea
DZNE, German Center for Neurodegenerative Disease, Bonn, Germany.
S
S
Roeske
Department of Neurosurgery, University Hospital, RFW University, Germany.
Á
Á
Güresir
Department of Neurosurgery, University Hospital, RFW University, Germany.
E
E
Güresir
Department of Neurosurgery, University Hospital, RFW University, Germany.
H
H
Vatter
D000328:Adult; D000368:Aged; D004599:Electric Stimulation Therapy / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D020773:Headache Disorders / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe; D059408:Pain Management / Q000379:methods; D011237:Predictive Value of Tests; D055815:Young Adult
Occipital nerve stimulation; percutaneous nerve field stimulation; presurgical predictive factor; refractory chronic headache disorders