Relationships Between Fasting Serum Amylase and Ghrelin or Peptide YY3-36 Levels in Healthy Men.
OBJECTIVE
Appetite and carbohydrate metabolism are important contributors to the development of obesity. Recently, low serum amylase was shown to be associated with obesity and metabolic disorder. We investigated the relationship between amylase and ghrelin or peptide YY (PYY) levels in healthy men.


METHODS
Twenty-one men were enrolled in this cross-sectional study; all subjects were asymptomatic with no medical history. Fasting serum amylase, ghrelin, PYY3-36, anthropometry, and nutritional intake were measured. Linear regression analyses were performed to examine associations between amylase and ghrelin or PYY3-36.


RESULTS
The mean (SD) age and waist circumference of the subjects were 51.5 (10.9) years and 87.0 (4.4) cm, respectively. Amylase was found to be correlated with waist circumference (r = -0.438, P = 0.054), ghrelin (r = 0.533, P = 0.015), and PYY3-36 (r = -0.511, P = 0.021). Multivariate linear regression analysis revealed a negative association between amylase and PYY3-36 (β = -0.428, P = 0.045) but a nonsignificantly positive association between amylase and ghrelin (β = 0.260, P = 0.146).


CONCLUSIONS
Amylase levels were found to be associated with ghrelin and PYY3-36 in healthy men. Amylase, ghrelin, and PYY3-36 may play a role in obesity; further research is required to identify the underlying mechanism.
From the *Department of Family Medicine, Pusan National University School of Medicine, Yangsan, South Korea; †Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea; ‡Medical Education Unit, Pusan National University School of Medicine, Yangsan, South Korea; §Obesity, Nutrition and Metabolism Clinic, Department of Family Medicine, Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea; and ∥Biomedical Research Institute, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Young Jin
YJ
Tak
Yu Hyeon
YH
Yi
Sang Yeoup
SY
Lee
Yun Jin
YJ
Kim
Jeong Gyu
JG
Lee
Young Hye
YH
Cho
D000328:Adult; D000681:Amylases / Q000097:blood*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004435:Eating; D005215:Fasting / Q000097:blood*; D054439:Ghrelin / Q000097:blood*; D064368:Healthy Volunteers; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010446:Peptide Fragments / Q000097:blood*; D019894:Peptide YY / Q000097:blood*; D055105:Waist Circumference
D054439:Ghrelin; D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36); D000681:Amylases