Platelet-Derived Growth Factor Inhibitors: A Potential Therapeutic Approach for Ocular Neovascularization.
Retinochoroidal vascular diseases are the leading causes of blindness in the developed world. They include diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity, age-related macular degeneration (AMD), and pathological myopia, among many others. Several different therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factors (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF play an important role in the angiogenesis cascade that is activated in retinochoroidal vascular diseases. The mechanism of action, side effects, efficacy, and the potential synergistic role of these agents in combination with other treatment options is discussed. The future of treatment of retinochoroidal vascular diseases, particularly neovascular AMD, has become more exciting due to agents like PDGF antagonists.
Mohammad Ali
MA
Sadiq
Mostafa
M
Hanout
Salman
S
Sarwar
Muhammad
M
Hassan
Aniruddha
A
Agarwal
Yasir Jamal
YJ
Sepah
Diana V
DV
Do
Quan Dong
QD
Nguyen
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D020256:Choroidal Neovascularization / Q000188:drug therapy*; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors*; D015861:Retinal Neovascularization / Q000188:drug therapy*
D020533:Angiogenesis Inhibitors; D010982:Platelet-Derived Growth Factor