Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium.
Potential environmental hazards of radionuclides are often studied at the individual level. Sufficient toxicogenomics data at the molecular/cellular level for understanding the effects and modes of toxic action (MoAs) of radionuclide is still lacking. The current article introduces transcriptomic data generated from a recent ecotoxicological study, with the aims to characterize the MoAs of a metallic radionuclide, deplete uranium (DU) in an ecologically and commercially important fish species, Atlantic salmon (Salmo salar). Salmon were exposed to three concentrations (0.25, 0.5 and 1.0 mg/L) of DU for 48 h. Short-term global transcriptional responses were studied using Agilent custom-designed high density 60,000-feature (60 k) salmonid oligonucleotide microarrays (oligoarray). The microarray datasets deposited at Gene Expression Omnibus (GEO ID: GSE58824) were associated with a recently published study by Song et al. (2014) in BMC Genomics. The authors describe the experimental data herein to build a platform for better understanding the toxic mechanisms and ecological hazard of radionuclides such as DU in fish.
Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CERAD), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), P.O. Box 5003, N-1432 Ås, Norway ; Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway.
You
Y
Song
Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CERAD), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), P.O. Box 5003, N-1432 Ås, Norway.
Brit
B
Salbu
Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CERAD), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), P.O. Box 5003, N-1432 Ås, Norway.
Hans-Christian
HC
Teien
Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CERAD), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), P.O. Box 5003, N-1432 Ås, Norway.
Lene Sørlie
LS
Heier
Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CERAD), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), P.O. Box 5003, N-1432 Ås, Norway ; Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Ecology and Natural Resource Management, P.O. Box 5003, N-1432 Ås, Norway.
Bjørn Olav
BO
Rosseland
Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway.
Tore
T
Høgåsen
Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CERAD), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), P.O. Box 5003, N-1432 Ås, Norway ; Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway.
Knut Erik
KE
Tollefsen
Atlantic salmon; Depleted uranium; Gene expression; Microarray; Stress response