A definitive haplotype map of structural variations determined by microarray analysis of duplicated haploid genomes.
Complete hydatidiform moles (CHMs) are tissues carrying duplicated haploid genomes derived from single sperms, and detecting copy number variations (CNVs) in CHMs is assumed to be sensitive and straightforward methods. We genotyped 108 CHM genomes using Affymetrix SNP 6.0 (GEO#: GSE18642) and Illumina 1 M-duo (GEO#: GSE54948). After quality control, we obtained 84 definitive haplotype consisting of 1.7 million SNPs and 2339 CNV regions. The results are presented in the database of our web site (http://orca.gen.kyushu-u.ac.jp/cgi-bin/gbrowse/humanBuild37D4_1/).
Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Tomoko
T
Tahira
Biostatistics Center, Kurume University, Kurume, Japan.
Koji
K
Yahara
Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan ; Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Yoji
Y
Kukita
Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan ; Center for Genomic Medicine, Kyoto University, Kyoto, Japan.
Koichiro
K
Higasa
Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kiyoko
K
Kato
Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Norio
N
Wake
Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Kenshi
K
Hayashi
Complete hydatidiform moles; Copy Number Variation; Definitive haplotypes; LD-bin; Single nucleotide polymorphism