Multipotent human stromal cells isolated from cord blood, term placenta and adult bone marrow show distinct differences in gene expression pattern.
Multipotent mesenchymal stromal cells derived from human placenta (pMSCs), and unrestricted somatic stem cells (USSCs) derived from cord blood share many properties with human bone marrow-derived mesenchymal stromal cells (bmMSCs) and are currently in clinical trials for a wide range of clinical settings. Here we present gene expression profiles of human cord blood-derived unrestricted somatic stem cells (USSCs), human placental-derived mesenchymal stem cells (hpMSCs), and human bone marrow-derived mesenchymal stromal cells (bmMSCs), all derived from four different donors. The microarray data are available on the ArrayExpress database (www.ebi.ac.uk/arrayexpress) under accession number E-TABM-880. Additionally, the data has been integrated into a public portal, www.stemformatics.org. Our data provide a resource for understanding the differences in MSCs derived from different tissues.
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, 4072, Australia ; Eskitis Institute for Drug Discovery, National Centre for Adult Stem Cell Research, Griffith University, Brisbane, 4111, Australia.
Nicholas
N
Matigian
Mater Medical Research Institute, University of Queensland, Woolloongabba, Brisbane, 4102, Australia.
Gary
G
Brooke
Murdoch Children's Research Institute, The University of Melbourne, Royal Children's Hospital, Parkville, Victoria, 3052, Australia.
Faten
F
Zaibak
Mater Medical Research Institute, University of Queensland, Woolloongabba, Brisbane, 4102, Australia.
Tony
T
Rossetti
Mater Medical Research Institute, University of Queensland, Woolloongabba, Brisbane, 4102, Australia.
Katarina
K
Kollar
Mater Medical Research Institute, University of Queensland, Woolloongabba, Brisbane, 4102, Australia.
Rebecca
R
Pelekanos
Mater Medical Research Institute, University of Queensland, Woolloongabba, Brisbane, 4102, Australia.
Celena
C
Heazlewood
Eskitis Institute for Drug Discovery, National Centre for Adult Stem Cell Research, Griffith University, Brisbane, 4111, Australia.
Alan
A
Mackay-Sim
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, 4072, Australia ; Eskitis Institute for Drug Discovery, National Centre for Adult Stem Cell Research, Griffith University, Brisbane, 4111, Australia ; The Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, The University of Glasgow, Scotland, G12 8TA, UK.
Christine A
CA
Wells
Mater Medical Research Institute, University of Queensland, Woolloongabba, Brisbane, 4102, Australia.
Kerry
K
Atkinson
Mesenchymal stem cells; Mesenchymal stromal cells; Multipotent human stromal cells