Drug-Loaded Perfluorocarbon Nanodroplets for Ultrasound-Mediated Drug Delivery.
The interaction of nanoparticles with directed energy is a novel application in targeted drug delivery. This chapter focuses on perfluorocarbon nanoemulsions, whose action in drug delivery depends on the ultrasound-triggered phase shift from liquid to gaseous state. These nanoemulsions have great potential for unloading encapsulated drugs at a desired time and location in the body in response to directed ultrasound. In addition, they actively alter their nano-environment for enhancing drug transport through various biological barriers to sites of action, which significantly enhances therapeutic outcome.
Department of Bioengineering, University of Utah, 36 South Wasatch Drive, Room, 3100, Salt Lake City, UT, 84112, USA. natasha.rapoport@utah.edu.
Natalya
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Rapoport
D016503:Drug Delivery Systems; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage*; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage*; D014465:Ultrasonics
D004655:Emulsions; D005466:Fluorocarbons; D008823:Micelles
Drug delivery; Perfluorocarbon nanodroplet; Ultrasound