Purple potato (Solanum tuberosum L.) anthocyanins attenuate alcohol-induced hepatic injury by enhancing antioxidant defense.
Alcoholic liver disease (ALD) is a serious and challenging health issue. In the past decade, natural components possessing hepatoprotective properties have gained more attention for ALD intervention. In this study, the phytochemical components of anthocyanins from purple potato were assessed using UPLC-MS/MS, and the hepatoprotective effects of purple potato anthocyanins (PPAs) were investigated in the ALD mouse model. Serum and liver biochemical parameters were determined, along with histopathological changes in liver tissue. In addition, the major contributors to alcohol-induced oxidative stress were assessed. The results indicated that the levels of aspartate transaminase and alanine transaminase were lower in the serum of the PPA-treated group than the alcohol-treated group. PPAs significantly inhibited the reduction of total cholesterol and triglycerides. Higher levels of superoxide dismutase and reduced glutathione enzymes as well as a reduction in the formation of malondialdehyde occurred in mice fed with PPAs. In addition, PPAs protected against increased alcohol-induced levels and activity of cytochrome P450 2E1 (CYP2E1), which demonstrates the effects of PPAs against alcohol-induced oxidative stress and liver injury. This study suggests that PPAs could be an effective therapeutic agent in alcohol-induced liver injuries by inhibiting CYP2E1 expression and thereby strengthening antioxidant defenses.
Zhihui
Z
Jiang
Chen
C
Chen
Jian
J
Wang
Wenyan
W
Xie
Meng
M
Wang
Xinsheng
X
Li
Xiaoying
X
Zhang
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000872:Anthocyanins / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D002784:Cholesterol / Q000378:metabolism; D002853:Chromatography, Liquid; D019392:Cytochrome P-450 CYP2E1 / Q000096:biosynthesis / Q000378:metabolism*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D013058:Mass Spectrometry; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D011897:Random Allocation; D011198:Solanum tuberosum / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D053719:Tandem Mass Spectrometry; D014280:Triglycerides / Q000378:metabolism
D000872:Anthocyanins; D000975:Antioxidants; D014280:Triglycerides; D000431:Ethanol; D008315:Malondialdehyde; D002784:Cholesterol; D019392:Cytochrome P-450 CYP2E1; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione