Impaired Cytokine but Enhanced Cytotoxic Marker Expression in Mycobacterium tuberculosis-Induced CD8+ T Cells in Individuals With Type 2 Diabetes and Latent Mycobacterium tuberculosis Infection.
Type 2 diabetes mellitus (DM) is a risk factor for tuberculosis among individuals with latent Mycobacterium tuberculosis infection. To explore the influence of DM on CD8(+) T-cell responses during latent M. tuberculosis infection, we estimated the cytokine and cytotoxic marker expression pattern in individuals with latent M. tuberculosis infection with DM and those with latent M. tuberculosis infection without DM. Among individuals with latent M. tuberculosis infection, those with DM had diminished frequencies of CD8(+) T-helper type 1 (Th1), Th2, and Th17 cells following stimulation by M. tuberculosis antigen and enhanced frequencies of CD8(+) T cells expressing cytotoxic markers, compared with those without DM. Thus, our results suggest that coincident DM modulates CD8(+) T-cell function during latent M. tuberculosis infection.
National Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research.
Nathella Pavan
NP
Kumar
National Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research.
Kadar
K
Moideen
National Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research.
Parakkal Jovvian
PJ
George
National Institute for Research in Tuberculosis, Chennai, India.
Chandrakumar
C
Dolla
National Institute for Research in Tuberculosis, Chennai, India.
Paul
P
Kumaran
National Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research.
Subash
S
Babu
D015415:Biomarkers; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D016022:Case-Control Studies; D002478:Cells, Cultured; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D055985:Latent Tuberculosis / Q000378:metabolism* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000502:physiology*
D015415:Biomarkers; D016207:Cytokines
CD8+ T cells; cytokines; diabetes mellitus; latent M. tuberculosis infection