Cochrane Corner: Colchicine in acute and recurrent pericarditis.
The potential anti-inflammatory effect of colchicine has been explored in many conditions, including pericarditis. The Cochrane Collaboration Systematic Review included four randomized controlled trials enrolling 564 patients with acute pericarditis (two studies) or recurrent pericarditis (two studies), followed for a period of 20-24 months. Colchicine was associated with a significant reduction in short-term persistence of chest pain and in long-term risk of recurrence of pericarditis. No significant increase in overall adverse events was observed. Despite the available evidence, the use of colchicine in this context remains strictly off-label.
Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina da Universidade de Lisboa, Portugal; Unidade de Farmacologia Clínica, Instituto de Medicina Molecular, Lisboa, Portugal; Serviço de Cardiologia, Hospital Garcia de Orta, Almada, Portugal. Electronic address: dgcaldeira@hotmail.com.
Daniel
D
Caldeira
Centro de Estudos de Medicina Baseada na Evidência, Faculdade de Medicina da Universidade de Lisboa, Portugal; Centro Colaborador Português da Rede Cochrane Iberoamericana, Lisboa, Portugal.
António
A
Vaz-Carneiro
Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina da Universidade de Lisboa, Portugal; Unidade de Farmacologia Clínica, Instituto de Medicina Molecular, Lisboa, Portugal; Centro de Estudos de Medicina Baseada na Evidência, Faculdade de Medicina da Universidade de Lisboa, Portugal; Centro Colaborador Português da Rede Cochrane Iberoamericana, Lisboa, Portugal.
João
J
Costa
D003078:Colchicine / Q000627:therapeutic use*; D006801:Humans; D010493:Pericarditis / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012196:Review Literature as Topic; D050257:Tubulin Modulators / Q000627:therapeutic use*
D050257:Tubulin Modulators; D003078:Colchicine
Chest pain; Colchicina; Colchicine; Dor torácica; Pericardite; Pericarditis