Acute BVDV-2 infection in beef calves delays humoral responses to a non-infectious antigen challenge.
Immunosuppressive effects of an intranasal challenge with non-cytopathic bovine viral diarrhea virus (BVDV) 2a (strain 1373) were assessed through acquired and innate immune system responses to ovalbumin (OVA). Concurrent BVDV infection was hypothesized to delay and reduce the humoral response to ovalbumin (administered on days 3 and 15 post-inoculation). Infected animals followed the expected clinical course. BVDV titers, and anti-BVDV antibodies confirmed the course of infection and were not affected by the administration of OVA. Both the T-helper (CD4(+)) and B-cell (CD20(+)) compartments were significantly (P < 0.05) reduced in infected animals, while the gamma-delta T-cell population (Workshop cluster 1+, WC1(+)) decreased slightly in numbers. Infection with BVDV delayed the increase in OVA IgG by approximately 3 d from day 12 through day 21 post-inoculation. Between days 25 and 37 post-inoculation following BVDV infection the IgM concentration in the BVDV- group decreased while the OVA IgM titer still was rising in the BVDV+ animals. Thus, active BVDV infection delays IgM and IgG responses to a novel, non-infectious antigen.
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Robert
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McCorkell
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Shawn R
SR
Horsman
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Katherine
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Wynne-Edwards
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Greg
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Muench
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Sylvia
S
van Drunen Littel-van den Hurk
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Regula
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Waeckerlin
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Michael
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Eschbaumer
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Rkia
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Dardari
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Mark
M
Chaiyakul
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Pawel
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Gajda
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Markus
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Czub
Faculty of Veterinary Medicine University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1 (McCorkell, Horsman, Wynne-Edwards, Muench, Waeckerlin, Eschbaumer, Dardari, Chaiyakul, Gajda, Czub, van der Meer); Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3 (van Drunen Littel-van den Hurk).
Frank
F
van der Meer
D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000821:virology*; D030242:Diarrhea Virus 2, Bovine Viral; D005260:Female; D007963:Leukocytes, Mononuclear; D008297:Male; D010047:Ovalbumin / Q000276:immunology*; D011897:Random Allocation
D010047:Ovalbumin