Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles.
Self-assembled cholesterol-asplatin-incorporated nanoparticles (SCANs) were prepared for oral delivery of a Pt(IV) prodrug. SCANs exhibit high gastrointestinal stability, sustained drug release and enhanced cell uptake. The oral bioavailability of SCANs was 4.32-fold higher than that of free Pt(IV) prodrugs. The oral administration of SCANs efficaciously inhibits tumor growth with negligible toxicity.
CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Qinqin
Q
Cheng
CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Hongdong
H
Shi
CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Hai
H
Huang
School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China. jwang699@ustc.edu.cn.
Zhiting
Z
Cao
School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China. jwang699@ustc.edu.cn.
Jun
J
Wang
CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. liuyz@ustc.edu.cn.
Yangzhong
Y
Liu
D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D017671:Platinum Compounds / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
D000970:Antineoplastic Agents; D008055:Lipids; D017671:Platinum Compounds; D011108:Polymers