Fluconazole exposure during pregnancy.
OBJECTIVE
One of my patients has just learned that she is 8 weeks pregnant. She took a 150-mg dose of fluconazole 2 weeks ago for the treatment of vaginal candidiasis and she is worried about the effect on her child and pregnancy. Can I reassure her?


CONCLUSIONS
Short-term and low-dose fluconazole exposure, such as that indicated in the treatment of vaginal candidiasis, is not expected to increase the overall risk of major congenital malformations.
Yusuf Cem
YC
Kaplan
Gideon
G
Koren
Pina
P
Bozzo
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology* / Q000209:etiology; D000935:Antifungal Agents / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000453:epidemiology*
D000935:Antifungal Agents; D015725:Fluconazole