Quercitrin offers protection against brain injury in mice by inhibiting oxidative stress and inflammation.
Quercitrin is one of the primary flavonoid compounds present in vegetables and fruits. The aim of the present study was to evaluate the effects of quercitrin against carbon tetrachloride (CCl4) induced brain injury and further to elucidate its probable mechanisms. ICR mice received CCl4 intraperitoneally with or without quercitrin co-administration for 4 weeks. Our data showed that quercitrin significantly suppressed the elevation of reactive oxygen species (ROS) production and malondialdehyde (MDA) content, reduced tissue plasminogen activator (t-PA) activity, enhanced the antioxidant enzyme activities and abrogated cytochrome P450 2E1 (CYP2E1) induction in mouse brains. Quercitrin also prevented CCl4 induced cerebral function disorders associated with its ability to inhibit the activities of monoamine oxidase (MAO), acetylcholine esterase (AChE) and the N-methyl-d-aspartate receptor 2B subunit (NR2B). In addition, western blot analysis showed that quercitrin suppressed the release of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). Taken together, our findings suggested that quercitrin may be a potential candidate to be developed as a neuroprotective agent.
School of Chemistry and Pharmaceutical Engineering, Sichuan University of Science and Engineering, No. 180, Huixing Road, 643000 Zigong City, Sichuan Province, PR China. a1032042419@126.com.
Jie-Qiong
JQ
Ma
School of Chemistry and Pharmaceutical Engineering, Sichuan University of Science and Engineering, No. 180, Huixing Road, 643000 Zigong City, Sichuan Province, PR China. a1032042419@126.com.
Rong-Zhen
RZ
Luo
School of Chemistry and Pharmaceutical Engineering, Sichuan University of Science and Engineering, No. 180, Huixing Road, 643000 Zigong City, Sichuan Province, PR China. a1032042419@126.com.
Hai-Xia
HX
Jiang
School of Life Science, Jiangsu Normal University, No. 101, Shanghai Road, Tongshan New Area, Xuzhou City 221116, Xuzhou City, Jiangsu Province, PR China.
Chan-Min
CM
Liu
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001930:Brain Injuries / Q000139:chemically induced* / Q000517:prevention & control; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D007249:Inflammation / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
C012526:quercitrin; D011794:Quercetin