Future Prospects for Periodontal Bioengineering Using Growth Factors.
Polypeptide growth factors have demonstrated strong potential to repair defects associated with teeth and dental implants. Over the past two decades, intense research efforts have led to the clinical development of several growth factors or biologic agents, including bone morphogenetic proteins, platelet-derived growth factor, fibroblast growth factors, and enamel matrix proteins. Several of these growth factors are now being used clinically for a variety of applications, such as the promotion of periodontal regeneration, sinus floor augmentation, and root coverage procedures. Although clinical results have been promising and growth factors add another dimension to clinical care, optimization of growth factor targeting approaches to periodontal wounds remains a challenge. Enhancement of growth factor local application to improve bioavailability, bioactivity, and allowance of three-dimensional reconstruction of complex anatomic defects is a goal. This article will highlight developments for growth factor delivery to better stimulate the wound healing response for periodontal and bone regeneration in the maxillofacial region.
Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, School of Dentistry, University of Michigan, Ann Arbor, MI.|Department of Biomedical Engineering, College of Engineering, University of Michigan.
William V
WV
Giannobile
Department of Biomedical Engineering, College of Engineering, University of Michigan.|Department of Surgery, School of Medicine, University of Michigan.
Scott J
SJ
Hollister
Department of Biomedical Engineering, College of Engineering, University of Michigan.|Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan.
Peter X
PX
Ma
Bone morphogenetic proteins; fibroblast growth factors; platelet-derived growth factor; regeneration; regenerative medicine; tissue engineering