Diagnosis of hepatitis C virus genotype 2k/1b needs NS5B sequencing.
Hepatitis C virus (HCV) is probably the most common cause of liver cirrhosis and hepatocellular carcinoma worldwide. The correct identification of HCV genotype has important clinical implications as a marker of responsiveness to antiviral therapy and serves as a guideline for the duration of treatment. The VERSANT HCV Genotype 2.0 Assay failed to detect HCV genotype 2k/1b. HCV genotype 2k/1b detection requires NS5B sequencing.
Department of Laboratory Medicine, Clinical Microbiology, AZ St-Jan Bruges-Ostend, Ruddershove 10, 8000 Bruges, Belgium.
Steven
S
De Keukeleire
Department of Laboratory Medicine, Clinical Microbiology, AZ St-Jan Bruges-Ostend, Ruddershove 10, 8000 Bruges, Belgium.
Patrick
P
Descheemaeker
Department of Laboratory Medicine, Clinical Microbiology, AZ St-Jan Bruges-Ostend, Ruddershove 10, 8000 Bruges, Belgium. Electronic address: marijke.reynders@azsintjan.be.
Marijke
M
Reynders
D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000627:therapeutic use; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*; D012324:RNA-Dependent RNA Polymerase
D000998:Antiviral Agents; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase
Belgium; HCV 2K/1b; Hepatitis C virus