Modulation of CD4+ and CD8+ T-Cell Function by Interleukin 19 and Interleukin 24 During Filarial Infections.
Interleukin 19 (IL-19) and interleukin 24 (IL-24) are cytokines that are highly expressed in filarial infections. To study the role of IL-19 and IL-24 in regulating T-cell responses, we examined the frequency of T-helper type 1 (Th1)/Tc1, Th2/Tc2, Th9/Tc9, Th17/Tc17, Th22/Tc22, and Tr1 cells in 26 filariae-infected individuals stimulated with filarial antigen following IL-19 or IL-24 neutralization. IL-19 or IL-24 neutralization resulted in significantly enhanced frequencies of Th1/Tc1 and/or Th17/Tc17 cells and significantly reduced frequencies of Th2/Tc2, Tr1, and/or Th9/Tc9 cells. Thus, we demonstrate that IL-19 and IL-24 are associated with the modulation of T-cell responses in filarial infections.
National Institutes of Health (NIH)-National Institute for Research in Tuberculosis (NIRT)-International Center for Excellence in Research.
Rajamanickam
R
Anuradha
National Institutes of Health (NIH)-National Institute for Research in Tuberculosis (NIRT)-International Center for Excellence in Research.
Saravanan
S
Munisankar
NIRT, Chennai, India.
Chandrakumar
C
Dolla
NIRT, Chennai, India.
Paul
P
Kumaran
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland.
Thomas B
TB
Nutman
National Institutes of Health (NIH)-National Institute for Research in Tuberculosis (NIRT)-International Center for Excellence in Research.
Subash
S
Babu
D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D005368:Filariasis / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism; D007378:Interleukins / Q000235:genetics / Q000378:metabolism*; D016176:T-Lymphocyte Subsets; D000099180:Interleukin-24
D016753:Interleukin-10; D007378:Interleukins; D000099180:Interleukin-24; C508609:IL10 protein, human; C421250:IL19 protein, human
IL-10; IL-19; IL-24; T cells; cytokines; filarial infections