Propolis aqueous extract preserves functional integrity of murine intestinal mucosa after exposure to ionizing radiation.
The ability of a specially prepared water propolis extract (PWE) to preserve the functional activity of the intestinal mucosa after radiation exposure was studied. PWE was given orally (650 mg/kg) to rats five days prior to irradiation by 6 Gy and continued for further two days. Rats were sacrificed 24h later, intestinal segments were examined histologically and homogenates were used to assess relevant biochemical parameters reflecting intestinal injury. Irradiation led to a rise in the histological damage score, a rise in tissue TNF-α and TBARS, and a decrease in sucrase, alkaline phosphatase, GSH and cholecystokinin as well as a decrease in plasma citrulline. The findings reflect a decrease in intestinal functional activity. PWE preserved the intestinal integrity and largely protected against the changes induced in the histology damage score and all parameters measured, possibly as a result of the antioxidant and anti-inflammatory action of its caffeic acid content.
Department of Pharmacology, Faculty of Pharmacy, Cairo University, Egypt. Electronic address: mtkhayyal@gmail.com.
Mohamed T
MT
Khayyal
Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
Rania M
RM
El-Hazek
Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
Mona A
MA
El-Ghazaly
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000528:radiation effects; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D011429:Propolis / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D011837:Radiation-Protective Agents; D002110:Caffeine; D011429:Propolis
Anti-inflammatory; Gamma irradiation; Intestinal function; Oxidative stress; Propolis