Hypoglycaemia, Abnormal Lipids, and Cardiovascular Disease among Chinese with Type 2 Diabetes.
We recruited a group of 6713 consecutive Chinese patients with T2D but normal renal and liver function who were admitted to one of 81 top tertiary care hospitals in China. Mild hypoglycaemia was defined as having symptomatic hypoglycaemia in one month before hospitalization. Severe hypoglycaemia was defined as having hypoglycaemia that needed assistance from other people in three months before hospitalization. Prior cardiovascular disease (CVD) was defined as having coronary heart disease, stroke, or peripheral arterial disease. Of 6713 patients, 80 and 304 had severe and mild hypoglycaemia episodes, respectively, and 561 had CVD. Patients with severe and mild hypoglycaemia episodes were more likely to have prior CVD (32.5% versus 16.5% versus 7.7%, P < 0.0001). Both mild and severe hypoglycaemia were associated with increased risk of CVD (adjusted odds ratios (ORs): 2.64, 95% CI: 1.85-3.76 for mild hypoglycaemia; 6.59, 95% CI: 3.79-11.45 for sever hypoglycaemia) than those patients free of hypoglycaemia. Further adjustment for lipid profile did not change these two ORs. In the same way, the ORs of lipid profile for CVD were similar before and after adjustment for hypoglycaemia. We concluded that hypoglycaemia and lipid profile were independently associated with increased risk of CVD.
Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
Yijun
Y
Li
Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
Yiming
Y
Mu
Department of Endocrinology, Xijing Hospital, 4th Military Medical University, Xi'an, Shaanxi 710032, China.
Qiuhe
Q
Ji
Department of Endocrinology, Changhai Hospital of Shanghai, Shanghai 200433, China.
Qin
Q
Huang
Department of Endocrinology, The Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
Hongyu
H
Kuang
Department of Endocrinology, Peking University People's Hospital, Beijing 100096, China.
Linong
L
Ji
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Xilin
X
Yang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications* / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000453:epidemiology; D007003:Hypoglycemia / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D055815:Young Adult