Use of Daptomycin in Critically Ill Children With Bloodstream Infections and Complicated Skin and Soft-tissue Infections.
We report our clinical experience with the use of daptomycin, administered in the dosage of 8 mg/kg/d in 3 minutes, in treating 12 critically ill children younger than 12 years, with bloodstream infections (n = 9) and complicated skin and soft-tissue infections (n = 3). Mean treatment duration was 14 ± 5 days; microbiologic eradication was achieved in all patients, and no drug related adverse events occurred.
From the *Department of Medical and Surgical Sciences, Infectious Diseases Unit, Teaching Hospital S. Orsola-Malpighi, University of Bologna, Bologna, Italy; and †Department of Haematology, Oncology, and Laboratory Medicine, Central Laboratory, Teaching Hospital S. Orsola-Malpighi, Bologna, Italy.
Sara
S
Tedeschi
Fabio
F
Tumietto
Matteo
M
Conti
Maddalena
M
Giannella
Pierluigi
P
Viale
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D017576:Daptomycin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D011446:Prospective Studies; D018805:Sepsis / Q000188:drug therapy*; D017192:Skin Diseases, Bacterial / Q000188:drug therapy*; D018461:Soft Tissue Infections / Q000188:drug therapy*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D017576:Daptomycin