[CARDIOVASCULAR DISEASES AS A RISK FACTOR OF CHRONIC GLOMERULONEPHRITIS PROGRESS].
The study was aimed at studying progression of chronic glomerulonephritis (CGN) associated with cardiovascular diseases (CVD).


METHODS
The clinical course of CGN with and without concomitant CVD was followed up in 75 men and 44 women aged 17-66 (mean 37.6 ± 12.9) years. Duration of the disease varied from 1 to 17 years. The appearance of persistent proteinuria and/or hematuria was regarded as the onset of the disease. The following laboratory parameters were recorded: hemoglobin level, packed cell volume, erythrocyte number daily proteinuria, glomerular filtration rate. CVD were diagnosed using electro- and echocardiography, veloergometry, and 24 hr Holter monitoring.


RESULTS
Patients with CGN and CVD showed a significantly increased serum creatinine level] 110 (180-181) vs 87 (64-134) mcmol/l, p = 0.01], reduced glomerular filtration rate [79.1 (41.1-104.5) vs 103.1 (67.2-146.8) ml/min, p = 0.0I] compared to the patients with CGN without CVD. Combination of CGN and CVD significantly decreased the 5 and 7 year survival rate.


CONCLUSIONS
Combination of CGN and SVD at the pre-dialysis stage deteriorates nitrogen excretion by the liver and reduces the liver survival rate.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications / Q000175:diagnosis*; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult