Conditional survival among patients with adrenal cortical carcinoma determined using a national population-based surveillance, epidemiology, and end results registry.
Surgical excision is essential for management of the rare and aggressive neoplasm adrenal cortical carcinoma (ACC). Five-year overall survival (OS) after surgery for ACC is dependent on disease stage, but for all stages the risk of death declines with time after surgery. We calculated the effect of post-surgical duration on conditional survival (CS) among ACC patients. A total of 641 patients with M0 ACC were selected from the Surveillance, Epidemiology, and End Results (SEER) registry (1988-2012). OS for the entire cohort at 1, 2, 3, 4, 5 and 6 years was 81.4%, 66.8%, 56.3%, 50.3%, 47.2% and 44.3%, respectively. CS for an additional year given prior survival for 0, 1, 2, 3, 4 or 5 years was 81.4%, 81.1%, 83.0%, 87.5%, 93.4% and 93.4%, respectively. Age, tumor stage, tumor grade and marital status affected OS and CS. Increases in 1-year CS over time were more pronounced in patients with poorer prognostic factors. With longer follow-up, tumor stage- and grade-dependent differences in CS decreased or even disappeared. CS may provide more meaningful life expectancy predictions for survivors of ACC than conventional survival analysis.
Department of Urology, Fudan University Shanghai Cancer Centre, Shanghai 200032, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Wen-jun
WJ
Xiao
Department of Urology, Fudan University Shanghai Cancer Centre, Shanghai 200032, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Yao
Y
Zhu
Department of Urology, Fudan University Shanghai Cancer Centre, Shanghai 200032, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Bo
B
Dai
Department of Urology, Fudan University Shanghai Cancer Centre, Shanghai 200032, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Hai-liang
HL
Zhang
Department of Urology, Fudan University Shanghai Cancer Centre, Shanghai 200032, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Guo-hai
GH
Shi
Department of Urology, Fudan University Shanghai Cancer Centre, Shanghai 200032, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Yi-jun
YJ
Shen
Department of Urology, Fudan University Shanghai Cancer Centre, Shanghai 200032, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Yi-ping
YP
Zhu
Department of Urology, Fudan University Shanghai Cancer Centre, Shanghai 200032, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
Ding-wei
DW
Ye
D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D000315:Adrenalectomy / Q000009:adverse effects / Q000401:mortality; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008017:Life Expectancy; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D018426:SEER Program; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D055815:Young Adult
adrenal cortical carcinoma; conditional survival; overall survival; surgical excision