The overweight: a rare presentation of celiac disease.
We describe the nutritional status of a cohort of celiac disease (CD) children at presentation and during follow-up on gluten-free diet (GFD). Two Italian centers (Rome and Bari) prospectively enrolled 445 biopsy-confirmed CD children, diagnosed between 2009 and 2013. Body Mass Index was used as a measure of nutritional status according to Italian growth charts of Cacciari. The overweight/obese subject was 7.8% at onset and did not significantly increase during follow-up (9.8% at final assessment). The prevalence of overweight/obesity was significantly higher among males than females. Furthermore, overweight/obesity children as compared with those with normal weight were significantly older and had significantly lower levels of tTG antibodies. This study shows that some CD children are obese/overweight at diagnosis; therefore, overweight/obesity can be considered a rare but a possible mode of CD presentation. Thus, CD diagnosis must be considered even in overweight/obese children where this diagnosis can be easily missed.
Gastroenterology-Hepatology and Nutrition Unit, 'Bambino Gesù' Children's Hospital, Rome, Italy.
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Capriati
Gastroenterology Unit, Pediatric Clinic of University, Bari, Italy.
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Francavilla
Hepato-Metabolic Diseases Unit, 'Bambino Gesù' Children's Hospital, Rome, Italy.
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Ferretti
Department of Pediatrics, San Paolo Hospital, Bari, Italy.
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Castellaneta
Gastroenterology-Hepatology and Nutrition Unit, 'Bambino Gesù' Children's Hospital, Rome, Italy.
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Ancinelli
Gastroenterology-Hepatology and Nutrition Unit, 'Bambino Gesù' Children's Hospital, Rome, Italy.
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Diamanti
D015992:Body Mass Index; D002446:Celiac Disease / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D009752:Nutritional Status; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D050177:Overweight / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors