Adenovirus necrotizing hepatitis complicating atypical teratoid rhabdoid tumor.
Adenovirus-induced fulminant hepatitis is rare. It has been reported in children with primary immunodeficiency, following transplantation or while receiving chemotherapy for hematological malignancy. We present the case of an infant recovering from chemotherapy for atypical teratoid rhabdoid tumor (ATRT) in whom a diagnosis of hepatic necrosis due to adenovirus was made.
Divisions of Immunology, Hematology, Oncology, Palliative Care and Environmental Health, University of Alberta, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Sarah J
SJ
McKillop
Divisions of Immunology, Hematology, Oncology, Palliative Care and Environmental Health, University of Alberta, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Mark J
MJ
Belletrutti
Infectious Disease, University of Alberta, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Bonita E
BE
Lee
Gastroenterology and Nutrition, University of Alberta, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Jason Y
JY
Yap
Departments of Radiology, University of Alberta, Edmonton, Alberta, Canada.
Michelle L
ML
Noga
Divisions of Immunology, Hematology, Oncology, Palliative Care and Environmental Health, University of Alberta, Edmonton, Alberta, Canada.|Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Sunil J
SJ
Desai
Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Consolato
C
Sergi
D000256:Adenoviridae / Q000235:genetics / Q000302:isolation & purification*; D001706:Biopsy; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology* / Q000821:virology; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis; D016133:Polymerase Chain Reaction; D018335:Rhabdoid Tumor / Q000150:complications* / Q000175:diagnosis; D013724:Teratoma / Q000150:complications* / Q000175:diagnosis
D004279:DNA, Viral
adenovirus; atypical teratoid/rhabdoid tumor; cidofovir; hepatic necrosis