Cross-Talk Between Ionic and Nanoribbon Current Signals in Graphene Nanoribbon-Nanopore Sensors for Single-Molecule Detection.
Nanopores are now being used not only as an ionic current sensor but also as a means to localize molecules near alternative sensors with higher sensitivity and/or selectivity. One example is a solid-state nanopore embedded in a graphene nanoribbon (GNR) transistor. Such a device possesses the high conductivity needed for higher bandwidth measurements and, because of its single-atomic-layer thickness, can improve the spatial resolution of the measurement. Here measurements of ionic current through the nanopore are shown during double-stranded DNA (dsDNA) translocation, along with the simultaneous response of the neighboring GNR due to changes in the surrounding electric potential. Cross-talk originating from capacitive coupling between the two measurement channels is observed, resulting in a transient response in the GNR during DNA translocation; however, a modulation in device conductivity is not observed via an electric-field-effect response during DNA translocation. A field-effect response would scale with GNR source-drain voltage (Vds), whereas the capacitive coupling does not scale with Vds . In order to take advantage of the high bandwidth potential of such sensors, the field-effect response must be enhanced. Potential field calculations are presented to outline a phase diagram for detection within the device parameter space, charting a roadmap for future optimization of such devices.
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA.|Department of Material Science and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Matthew
M
Puster
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Adrian
A
Balan
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Julio A
JA
Rodríguez-Manzo
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA.|Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Gopinath
G
Danda
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jae-Hyuk
JH
Ahn
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA.
William
W
Parkin
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Marija
M
Drndić
D004247:DNA / Q000737:chemistry; D004560:Electricity; D006108:Graphite / Q000737:chemistry*; D007477:Ions; D058608:Nanopores; D036103:Nanotechnology / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*
D007477:Ions; D037742:Nanotubes, Carbon; D006108:Graphite; D004247:DNA
DNA sequencing; TEM; graphene nanoribbons; nanopores; sensors; silicon nitrides