Regulation of neuronal migration, an emerging topic in autism spectrum disorders.
Autism spectrum disorders (ASD) encompass a group of neurodevelopmental diseases that demonstrate strong heritability, however, the inheritance is not simple and many genes have been associated with these disorders. ASD is regarded as a neurodevelopmental disorder, and abnormalities at different developmental stages are part of the disease etiology. This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration. We propose that neuronal migration impairment may be an important common pathophysiology in autism spectrum disorders (ASD). This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration.
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Orly
O
Reiner
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Eyal
E
Karzbrun
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Aditya
A
Kshirsagar
Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Showa, Nagoya, Japan.
Kozo
K
Kaibuchi
D000067877:Autism Spectrum Disorder / Q000235:genetics / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D055495:Neurogenesis / Q000235:genetics; D009474:Neurons / Q000502:physiology*
Astrotactin 2 ASTN2; Autism susceptibility candidate 2 AUTS2; Contactin-associated protein-like 2 CNTNAP2; Distal-less homeobox 1/2 DLX1/2; Neuronal migration; NudE nuclear distribution E homolog 1 NDE1