Carbapenem-Resistant Enterobacteriaceae in Children, United States, 1999-2012.
The prevalence of carbapenem-resistant Enterobacteriaceae (CRE) infections is increasing in the United States. However, few studies have addressed their epidemiology in children. To phenotypically identify CRE isolates cultured from patients 1-17 years of age, we used antimicrobial susceptibilities of Enterobacteriaceae reported to 300 laboratories participating in The Surveillance Network-USA database during January 1999-July 2012. Of 316,253 isolates analyzed, 266 (0.08%) were identified as CRE. CRE infection rate increases were highest for Enterobacter species, blood culture isolates, and isolates from intensive care units, increasing from 0.0% in 1999-2000 to 5.2%, 4.5%, and 3.2%, respectively, in 2011-2012. CRE occurrence in children is increasing but remains low and is less common than that for extended-spectrum β-lactamase-producing Enterobacteriaceae. The molecular characterization of CRE isolates from children and clinical epidemiology of infection are essential for development of effective prevention strategies.
Latania K
LK
Logan
John P
JP
Renschler
Sumanth
S
Gandra
Robert A
RA
Weinstein
Ramanan
R
Laxminarayan
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000276:immunology / Q000627:therapeutic use*; D015780:Carbapenems / Q000276:immunology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology; D004755:Enterobacteriaceae / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D006801:Humans; D007223:Infant; D007362:Intensive Care Units; D015995:Prevalence; D014481:United States
D000900:Anti-Bacterial Agents; D015780:Carbapenems
CRE; Surveillance Network–USA database; United States; antibacterial agents; antimicrobial resistance; bacteria; carbapenem-resistant Enterobacteriaceae; children; epidemiology; infections; β-lactamases