Renal-type clear cell carcinoma of the prostate: a diagnostic challenge.
A 72-year-old male presented with urinary symptoms. His serum prostate specific antigen level was 65.2 ng/ml. His radical prostatectomy specimen showed clear cell lesion reminiscent of the clear cell renal cell carcinoma along with acinar type of prostatic adenocarcinoma, Gleason score 4 + 4. The lesional clear cells were positive for pancytokeratin, epithelial membrane antigen, CD10, vimentin, and AMACR while negative for 34βE12, CK7, prostate specific antigen, and PAX8. The final diagnosis was renal-type clear cell carcinoma of the prostate. A follow-up of 20 months did not show metastasis. We herein report fifth case of renal-type clear cell carcinoma of the prostate.
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, UP, India. scupatne@gmail.com.
Shashikant C U
SC
Patne
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, UP, India. johri.nidhi2712@gmail.com.
Nidhi
N
Johri
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, UP, India. drrichakati@gmail.com.
Richa
R
Katiyar
Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, UP, India. drsameertrivedi@gmail.com.
Sameer
S
Trivedi
Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, UP, India. hodurology@gmail.com.
Uday Shankar
US
Dwivedi
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000601:surgery; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen