The circadian system as an organizer of metabolism.
The regulation of metabolism by circadian systems is believed to be a key reason for the extensive representation of circadian rhythms within the tree of life. Despite this, surprisingly little work has focused on the link between metabolism and the clock in Neurospora, a key model system in circadian research. The analysis that has been performed has focused on the unidirectional control from the clock to metabolism and largely ignored the feedback from metabolism on the clock. Recent efforts to understand these links have broken new ground, revealing bidirectional control from the clock to metabolism and vise-versa, showing just how strongly interconnected these two cellular systems can be in fungi. This review describes both well understood and emerging links between the clock and metabolic output of fungi as well as the role that metabolism plays in influencing the rhythm set by the clock.
Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. Electronic address: hurlej2@rpi.edu.
Jennifer M
JM
Hurley
Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Jennifer J
JJ
Loros
Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Jay C
JC
Dunlap
D056926:CLOCK Proteins / Q000502:physiology*; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D025461:Feedback, Physiological; D005656:Fungal Proteins / Q000378:metabolism; D005658:Fungi / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D053858:Metabolic Networks and Pathways
D005656:Fungal Proteins; D056926:CLOCK Proteins
Circadian; Clock-controlled genes; Metabolism; Neurospora; Output