IFN-γ Priming Effects on the Maintenance of Effector Memory CD4(+) T Cells and on Phagocyte Function: Evidences from Infectious Diseases.
Although it has been established that effector memory CD4(+) T cells play an important role in the protective immunity against chronic infections, little is known about the exact mechanisms responsible for their functioning and maintenance, as well as their effects on innate immune cells. Here we review recent data on the role of IFN-γ priming as a mechanism affecting both innate immune cells and effector memory CD4(+) T cells. Suboptimal concentrations of IFN-γ are seemingly crucial for the optimization of innate immune cell functions (including phagocytosis and destruction of reminiscent pathogens), as well as for the survival and functioning of effector memory CD4(+) T cells. Thus, IFN-γ priming can thus be considered an important bridge between innate and adaptive immunity.
Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Prof. Lineu Prestes 1730, 05508-000 São Paulo, SP, Brazil ; Department of Laboratory Medicine and Pathology, University of Minnesota, 2101 6th Street SE, Room 2-280, Minneapolis, MN 55414, USA.
Henrique
H
Borges da Silva
Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Prof. Lineu Prestes 1730, 05508-000 São Paulo, SP, Brazil.
Raíssa
R
Fonseca
Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Prof. Lineu Prestes 1730, 05508-000 São Paulo, SP, Brazil.
José M
JM
Alvarez
Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Prof. Lineu Prestes 1730, 05508-000 São Paulo, SP, Brazil.
Maria Regina
MR
D'Império Lima
D056704:Adaptive Immunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003141:Communicable Diseases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology*
D007371:Interferon-gamma