Regulation of sister chromatid cohesion during the mitotic cell cycle.
Orderly execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids during DNA replication in a process termed sister chromatid cohesion. Timely establishment and dissolution of sister chromatid cohesion is a prerequisite for accurate chromosome segregation, and is tight regulated by the cell cycle machinery and cohesin-associated proteins. In this review, we discuss recent progress in the molecular understanding of sister chromatid cohesion during the mitotic cell cycle.
Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Ge
G
Zheng
Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Hongtao.Yu@utsouthwestern.edu.
HongTao
H
Yu
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D002842:Chromatids / Q000502:physiology*; D020090:Chromosome Segregation / Q000502:physiology*; D004261:DNA Replication / Q000235:genetics; D006801:Humans; D018386:Kinetochores / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological
D018797:Cell Cycle Proteins
DNA replication; cell cycle; cohesin; cohesin loading; cohesin release; cohesion establishment; mitosis; sister chromatid cohesion