A comparative study of dydrogesterone and micronized progesterone for luteal phase support during in vitro fertilization (IVF) cycles.
The aim of the present study was to compare the efficacy, tolerability and patients' satisfaction after the use of oral dydrogesterone with vaginal micronized progesterone for luteal-phase support (LPS) among infertile women undergoing in vitro fertilization (IVF). A total of 210 women (aged 20-40 years old) with a history of infertility, who underwent controlled ovarian stimulation for fresh intra-cytoplasmic sperm injection-embryo transfer cycles, were included in the study. Consequently, they were randomized to receive LPS with dydrogesterone 20 mg twice daily (n = 96) or micronized progesterone 400 mg twice daily at the day of oocyte retrieval (n = 114). The clinical success rate (31% versus 33%; p = 0.888), miscarriage rate (5.0% versus 3.0%; p = 0.721), ongoing pregnancy rate (30.0% versus 30.0%; p = 1.000), implantation (22.0% versus 24.0%; p = 0.254) and multiple pregnancy rate (5.30% versus 7.20%; p = 0.394) were comparable among the two groups. Serum progesterone levels were significantly lower among the patients receiving dydrogesterone than the control group (13.62 ± 13.83 ng/ml versus 20.66 ± 18.09 ng/ml; p = 0.001). However, there was no statistically significant difference regarding the patients' satisfaction (p = 0.825) and tolerability (0.790) between the two groups. Our results showed that oral dydrogesterone (40 mg/day) is as effective as vaginal micronized progesterone considering its clinical outcomes and patients' satisfaction and tolerability, for LPS among women undergoing IVF.
a Preventive Gynecology Research Center (PGRC) , Shahid Beheshti University of Medical Sciences , Tehran , Iran .
Nasrin
N
Saharkhiz
a Preventive Gynecology Research Center (PGRC) , Shahid Beheshti University of Medical Sciences , Tehran , Iran .
Marzieh
M
Zamaniyan
a Preventive Gynecology Research Center (PGRC) , Shahid Beheshti University of Medical Sciences , Tehran , Iran .
Saghar
S
Salehpour
a Preventive Gynecology Research Center (PGRC) , Shahid Beheshti University of Medical Sciences , Tehran , Iran .
Shahrzad
S
Zadehmodarres
a Preventive Gynecology Research Center (PGRC) , Shahid Beheshti University of Medical Sciences , Tehran , Iran .
Sedighe
S
Hoseini
b Research Institute for Endocrine Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran .
Leila
L
Cheraghi
c Department of Veterinary Theriogenology and Obstetric , Tehran University of Medical Sciences , Tehran , Iran , and.
Samira
S
Seif
d Department of Anatomy , Faculty of Medical Sciences, Tarbiat Modares University , Tehran , Iran.
Nafiseh
N
Baheiraei
D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D004394:Dydrogesterone / Q000008:administration & dosage*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage*; D011372:Progestins / Q000008:administration & dosage*; D011446:Prospective Studies; D055815:Young Adult
D011372:Progestins; D011374:Progesterone; D004394:Dydrogesterone
Dydrogesterone; in vitro fertilization; luteal-phase support; micronized progesterone; progesterone