Screening of Glaucoma or Cataract Prevalence in Vitiligo Patients and Its Relationship With Periorbital Steroid Use.
OBJECTIVE
There is scarce literature connecting vitiligo and primary open angle glaucoma (POAG). Most literature reports that secondary complications are a direct consequence of corticosteroid treatment of vitiligo. In this study, we aimed to investigate the prevalence of ocular problems in patients with vitiligo and to determine its association with periorbital topical corticosteroid use.


METHODS
A cross-sectional study was carried out on 90 patients with vitiligo. The Vitiligo European Task Force questionnaire was completed for each patient. A control group comprising 90 healthy individuals who did not have vitiligo and who were matched on age and gender was used for comparison. A complete ophthalmologic examination was performed. A family history of glaucoma and the use of topical steroids were recorded.


RESULTS
Two (2/90, 2.2%) of the patients with vitiligo had glaucoma compared with none of the individuals in the control group (P = .25). Nineteen of the 90 patients with vitiligo used periorbital steroids, and of these patients, 10.5% (2/19) developed glaucoma. The duration of periorbital corticosteroid use was 4.50 ± 2.1 years. Eighty-nine percent (17/19) of the vitiligo patients who applied the potent topical corticosteroid (class I) clobetasol propionate to the periorbital area did not develop glaucoma. In contrast, glaucoma was not observed in 79% (71/90) of the vitiligo patients who did not use steroids. Cataract, uveitis, or fundus problems were not observed in either group.


CONCLUSIONS
The study suggests that patients who have vitiligo and use topical steroids periorbitally do not have an increased risk of glaucoma or cataracts. Future studies that have a larger sample size and use a detailed steroid use protocol are needed.
Vitiligo Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Huma
H
Khurrum
Vitiligo Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia Dermatology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia khalid@dralghamdi.net.
Khalid M
KM
AlGhamdi
Ophthalmology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Essam
E
Osman
D000328:Adult; D002386:Cataract / Q000453:epidemiology* / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000453:epidemiology* / Q000209:etiology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D007267:Injections; D008297:Male; D008403:Mass Screening / Q000379:methods*; D009915:Orbit; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012529:Saudi Arabia / Q000453:epidemiology; D014820:Vitiligo / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*
D005938:Glucocorticoids
cataract; glaucoma; periorbital; topical steroids; vitiligo