Animal and cellular models of human disease.
In this eighteenth (2016) Annual Review Issue of The Journal of Pathology, we present a collection of 19 invited review articles that cover different aspects of cellular and animal models of disease. These include genetically-engineered models, chemically-induced models, naturally-occurring models, and combinations thereof, with the focus on recent methodological and conceptual developments across a wide range of human diseases.
Centre for Comparative Pathology, University of Edinburgh, Edinburgh, UK.
Mark J
MJ
Arends
Division of Pulmonary & Critical Care Medicine, Department of Medicine, University of Michigan Medical School, Ann Arbor, USA.
Eric S
ES
White
The Roslin Institute, University of Edinburgh, Edinburgh, UK.
C Bruce A
CB
Whitelaw
D000818:Animals; D004195:Disease Models, Animal; D005355:Fibrosis; D030342:Genetic Diseases, Inborn; D006801:Humans; D007154:Immune System Diseases; D007249:Inflammation; D008954:Models, Biological; D009369:Neoplasms; D017410:Practice Guidelines as Topic; D012107:Research Design
3D xenografts; CRISPR/Cas9; HPV; MINPEPA; Wnt signalling; animal pathology reporting guidelines; atherosclerosis; behavioural testing; clear cell carcinoma; cone dystrophy; cystic fibrosis; diabetes; endometrioid carcinoma; endometriosis; epigenetic mutation; fibrosis; gasotransmitter; hydrogen sulphide; idiopathic pulmonary fibrosis; immunotherapy; incretin; inflammatory bowel disease; invasion; macular degeneration; melanoma; neurodegenerative disease; non-invasive bio-imaging; obesity; organoid culture; ovarian serous carcinoma; pancreatic ductal adenocarcinoma; patient-derived tumour xenografts; regeneration; tumour microenvironment; tumourigenesis; viral oncogenesis; xenotransplantation