Centrosomes and cancer: revisiting a long-standing relationship.
Over a century ago, centrosome aberrations were postulated to cause cancer by promoting genome instability. The mechanisms governing centrosome assembly and function are increasingly well understood, allowing for a timely reappraisal of this postulate. This Review discusses recent advances that shed new light on the relationship between centrosomes and cancer, and raise the possibility that centrosome aberrations contribute to this disease in different ways than initially envisaged.
Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland.
Pierre
P
Gönczy
D000818:Animals; D018385:Centrosome / Q000502:physiology*; D002869:Chromosome Aberrations; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*