Nanotechnology and bio-functionalisation for peripheral nerve regeneration.
There is a high clinical demand for new smart biomaterials, which stimulate neuronal cell proliferation, migration and increase cell-material interaction to facilitate nerve regeneration across these critical-sized defects. This article briefly reviews several up-to-date published studies using Arginine-Glycine-Aspartic acid peptide sequence, nanocomposite based on polyhedral oligomeric silsesquioxane nanoparticle and nanofibrous scaffolds as promising strategies to enhance peripheral nerve regeneration by influencing cellular behaviour such as attachment, spreading and proliferation. The aim is to establish the potent manipulations, which are simple and easy to employ in the clinical conditions for nerve regeneration and repair.
Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK.
Tina
T
Sedaghati
Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK ; Royal Free NHS Trust Foundation Hospital, London, UK ; NanoRegMed Ltd, London, UK.
Alexander M
AM
Seifalian
biomaterial; nanomaterial; nanotechnology; nerve regeneration; peptides; regenerative medicine; stem cells