Second messenger - Sensing riboswitches in bacteria.
Signal sensing in bacteria has traditionally been attributed to protein-based factors. It is however becoming increasingly clear that bacteria also exploit RNAs to serve this role. This review discusses how key developmental processes in bacteria, such as community formation, choice of a sessile versus motile lifestyle, or vegetative growth versus dormant spore formation may be governed by signal sensing RNAs. The signaling molecules that affect these processes, the RNAs that sense these molecules and the underlying molecular basis for specific signal-response are discussed here.
National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore 560065, India. Electronic address: arati@ncbs.res.in.
Arati
A
Ramesh
D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D001665:Binding Sites; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D015226:Dinucleoside Phosphates / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D012329:RNA, Bacterial / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D058928:Riboswitch / Q000235:genetics*; D015290:Second Messenger Systems; D015398:Signal Transduction
D015226:Dinucleoside Phosphates; D012329:RNA, Bacterial; D058928:Riboswitch; C528998:cyclic diadenosine phosphate; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP
Biofilms; Differentiation; Riboswitch; Second messenger; Sporulation