Long-term survival in a patient with head and neck paraganglioma treated with tailored modalities for 20 years: a case report.
OBJECTIVE
Primary paragangliomas of nasal cavity and paranasal sinus are rare conditions that could show aggressive behavior with local recurrence and metastasis development. The diagnosis of malignancy is challenging because there are no available histopathologic criteria. In these cases, the prognosis is usually poor.


METHODS
We report a case of a woman with malignant paranasal sinus paragangliomas.


RESULTS
The patient was treated with several surgical approaches, radiotherapy, and medical therapy for different recurrences.


CONCLUSIONS
Despite the malignant behavior of the disease, this patient is still alive many years after first diagnosis.
Division of Radiation Oncology, AOU IRCCS San Martino-IST National Cancer Research Institute and University, Genoa - Italy.
Liliana
L
Belgioia
Division of Medical Physics, AOU IRCCS San Martino-IST National Cancer Research Institute and University, Genoa - Italy.
Francesco
F
Pupillo
Division of Radiation Oncology, AOU IRCCS San Martino-IST National Cancer Research Institute and University, Genoa - Italy.
Almalina
A
Bacigalupo
Division of Radiation Oncology, AOU IRCCS San Martino-IST National Cancer Research Institute and University, Genoa - Italy.
Renzo
R
Corvò
D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010235:Paraganglioma / Q000175:diagnosis / Q000628:therapy*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000628:therapy; D017741:Survivors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome