Selective Heterogeneous C-H Activation/Halogenation Reactions Catalyzed by Pd@MOF Nanocomposites.
A directed heterogeneous C-H activation/halogenation reaction catalyzed by readily synthesized Pd@MOF nanocatalysts was developed. The heterogeneous Pd catalysts used were a novel and environmentally benign Fe-based metal-organic framework (MOF)(Pd@MIL-88B-NH2(Fe)) and the previously developed Pd@MIL-101-NH2(Cr). Very high conversions and selectivities were achieved under very mild reaction conditions and in short reaction times. A wide variety of directing groups, halogen sources, and substitution patterns were well tolerated, and valuable polyhalogenated compounds were synthesized in a controlled manner. The synthesis of the Pd-functionalized Fe-based MOF and the recyclability of the two catalysts are also presented.
Department of Organic Chemistry, Stockholm University, Stockholm, 10691, Sweden.|Berzelii Center EXSELENT on Porous Materials, Stockholm University, Stockholm, 10691, Sweden.
Vlad
V
Pascanu
Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, 10691, Sweden.|Berzelii Center EXSELENT on Porous Materials, Stockholm University, Stockholm, 10691, Sweden.
Fabian
F
Carson
Department of Organic Chemistry, Stockholm University, Stockholm, 10691, Sweden.|Berzelii Center EXSELENT on Porous Materials, Stockholm University, Stockholm, 10691, Sweden.
Marta Vico
MV
Solano
Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, 10691, Sweden.|Berzelii Center EXSELENT on Porous Materials, Stockholm University, Stockholm, 10691, Sweden.
Jie
J
Su
Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, 10691, Sweden.|Berzelii Center EXSELENT on Porous Materials, Stockholm University, Stockholm, 10691, Sweden.
Xiaodong
X
Zou
CVMD iMed, Medicinal Chemistry, AstraZeneca R&D, Mölndal, 43183, Sweden.
Magnus J
MJ
Johansson
Department of Organic Chemistry, Stockholm University, Stockholm, 10691, Sweden. belen.martin.matute@su.se.|Berzelii Center EXSELENT on Porous Materials, Stockholm University, Stockholm, 10691, Sweden. belen.martin.matute@su.se.
Belén
B
Martín-Matute
C−H activation; halogenation; heterogeneous catalysis; metal-organic frameworks; nanocatalysts