Time-averaged serum potassium levels and its fluctuation associate with 5-year survival of peritoneal dialysis patients: two-center based study.
The time-averaged serum potassium was more comprehensive to reflect the all-time changes of serum potassium levels during peritoneal dialysis (PD). However, the association of fluctuation of time-averaged serum potassium level with long-time survival of PD patients remains unknown. In this retrospective study, we included 357 incident PD patients in 2 centers from January 1, 2007 to October 31, 2012 with follow-up through October 31, 2014. Our data demonstrated that it was the lower time-averaged serum potassium level rather than baseline of serum potassium level that was associated with high risk of death. Patients with higher standard deviation (SD) had significantly poorer all-cause (p = 0.016) and cardiovascular mortality (p = 0.041). Among the patients with time-averaged serum potassium levels below 4.0 mEq/L, a lower mean value was more important than its SD to predict death risk. In contrast, the patients with time-averaged serum potassium levels above 4.0 mEq/L, those with serum potassium SD < 0.54 mEq/L, exhibited a higher 3-year and 5-year survival rate for both all-cause and cardiovascular mortality compared to the control groups. Our data clearly suggested both time-averaged serum potassium and its fluctuation contributed disproportionately to the high death risk in PD patients.
Division of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Shen-Heng
SH
Li
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical science, Guangzhou, 510080, China.
Jian-Teng
JT
Xie
Division of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Hai-Bo
HB
Long
Division of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Jun
J
Zhang
Division of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Wei-Dong
WD
Zhou
Division of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Hong-Xin
HX
Niu
Division of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Xun
X
Tang
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical science, Guangzhou, 510080, China.
Zhong-Lin
ZL
Feng
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical science, Guangzhou, 510080, China.
Zhi-Ming
ZM
Ye
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical science, Guangzhou, 510080, China.
Yang-Yang
YY
Zuo
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical science, Guangzhou, 510080, China.
Lei
L
Fu
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical science, Guangzhou, 510080, China.
Feng
F
Wen
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical science, Guangzhou, 510080, China.
Li-Ping
LP
Wang
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical science, Guangzhou, 510080, China.
Wen-Jian
WJ
Wang
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical science, Guangzhou, 510080, China.
Wei
W
Shi
D002318:Cardiovascular Diseases / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000401:mortality*; D011188:Potassium / Q000097:blood*; D012189:Retrospective Studies; D012306:Risk; D015996:Survival Rate
D011188:Potassium