The Regulatory T Cell: Jack-Of-All-Trades.
Foxp3(+) regulatory T (Treg) cells suppress auto-reactive and inflammatory T cells to maintain immune homeostasis. In a recent study, Rudensky and colleagues demonstrate the ability of Treg cells to facilitate tissue repair, a non-canonical Treg cell function accomplished by amphiregulin and mediated by cytokines interleukin (IL)-18 and IL-33.
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia; The Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3010, Australia.
Ajithkumar
A
Vasanthakumar
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia; The Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3010, Australia. Electronic address: kallies@wehi.edu.au.
Axel
A
Kallies
D000818:Animals; D006801:Humans; D007251:Influenza, Human / Q000276:immunology*; D008168:Lung / Q000166:cytology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000276:immunology*