Simple route for nano-hydroxyapatite properties expansion.
Simple surface modification of nano-hydroxyapatite, through acid-basic reactions, allows expanding the properties of this material. Introduction of organic groups such as hydrophobic alkyl chains, carboxylic acid, and amide or amine basic groups on the hydroxyapatite surface systematically change the polarity, surface area, and reactivity of hydroxyapatite without modifying its phase. Physical and chemical properties of the new derivative particles were analyzed. The biocompatibility of modified Nano-Hap on Raw 264.7 cells was also assessed.
Escuela de Química, Universidad de Costa Rica, San José, Costa Rica. Centro de Electroquímica y Energía Química (CELEQ), Universidad de Costa Rica, San José, Costa Rica.
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L
Rojas
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H
Olmedo
A J
AJ
García-Piñeres
C
C
Silveira
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L
Tasic
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F
Fraga
M L
ML
Montero
D000818:Animals; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D017886:Durapatite / Q000138:chemical synthesis* / Q000633:toxicity*; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure*; D010316:Particle Size; D044367:Phase Transition; D000067996:RAW 264.7 Cells; D013499:Surface Properties
D018786:Bone Substitutes; D017886:Durapatite