Effect of topical propranolol gel on plasma renin, angiotensin II and vascular endothelial growth factor in superficial infantile hemangiomas.
The effect of topical propranolol gel on the levels of plasma renin, angiotensin II (ATII) and vascular endothelial growth factor (VEGF) in superficial infantile hemangiomas (IHs) was investigated. Thirty-three consecutive children with superficial IHs were observed pre-treatment, 1 and 3 months after application of topical propranolol gel for the levels of plasma renin, ATII and VEGF in Department of General Surgery of Dongfang Hospital from February 2013 to February 2014. The plasma results of IHs were compared with those of 30 healthy infants of the same age from out-patient department. The clinical efficiency of topical propranolol gel at 1st, and 3rd month after application was 45%, and 82% respectively. The levels of plasma renin, ATII and VEGF in patients pre-treatment were higher than those in healthy infants (565.86 ± 49.66 vs. 18.19 ± 3.56, 3.20 ± 0.39 vs 0.30 ± 0.03, and 362.16 ± 27.29 vs. 85.63 ± 8.14, P < 0.05). The concentrations of VEGF and renin at 1st and 3rd month after treatment were decreased obviously as compared with those pre-treatment (271.51 ± 18.59 vs. 362.16 ± 27.29, and 405.18 ± 42.52 vs. 565.86 ± 49.66 P < 0.05; 240.80 ± 19.89 vs. 362.16 ± 27.29, and 325.90 ± 35.78 vs. 565.86 ± 49.66, P < 0.05, respectively), but the levels of plasma ATII declined slightly (2.96 ± 0.37 vs. 3.20 ± 0.39, and 2.47 ± 0.27 vs. 3.20 ± 0.39, P > 0.05). It was indicated that the increased renin, ATII and VEGF might play a role in the onset or development of IHs. Propranolol gel may suppress the proliferation of IHs by reducing VEGF.
Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou, 350025, China.|Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, China.|Department of Vascular Surgery, Hubei Provincial Hospital of TCM, Wuhan, 430000, China.
Yu-Juan
YJ
Tang
Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou, 350025, China.|Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, China.|Department of General Surgery, Fuzhou Clinic Medical College, Fujian Medical University, Fuzhou, 350025, China.
Zai-Zhong
ZZ
Zhang
Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou, 350025, China.|Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, China.|Department of General Surgery, Fuzhou Clinic Medical College, Fujian Medical University, Fuzhou, 350025, China.
Shao-Quan
SQ
Chen
Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou, 350025, China.|Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, China.|Department of General Surgery, Fuzhou Clinic Medical College, Fujian Medical University, Fuzhou, 350025, China.
Shu-Ming
SM
Chen
Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou, 350025, China.|Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, China.|Department of General Surgery, Fuzhou Clinic Medical College, Fujian Medical University, Fuzhou, 350025, China.
Cheng-Jin
CJ
Li
Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou, 350025, China.|Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, China.|Department of General Surgery, Fuzhou Clinic Medical College, Fujian Medical University, Fuzhou, 350025, China.
Jian-Wei
JW
Chen
Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou, 350025, China.|Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, China.|Department of General Surgery, Fuzhou Clinic Medical College, Fujian Medical University, Fuzhou, 350025, China.
Bo
B
Yuan
Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou, 350025, China. xiayin1118@163.com.|Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, China. xiayin1118@163.com.|Department of General Surgery, Fuzhou Clinic Medical College, Fujian Medical University, Fuzhou, 350025, China. xiayin1118@163.com.
Yin
Y
Xia
Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou, 350025, China. fzptwk@126.com.|Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou, 350025, China. fzptwk@126.com.|Department of General Surgery, Fuzhou Clinic Medical College, Fujian Medical University, Fuzhou, 350025, China. fzptwk@126.com.
Lie
L
Wang
D000279:Administration, Cutaneous; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000804:Angiotensin II / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005782:Gels; D018324:Hemangioma, Capillary / Q000097:blood / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D012083:Renin / Q000097:blood*; D012878:Skin Neoplasms / Q000097:blood / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D005782:Gels; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000804:Angiotensin II; D011433:Propranolol; D012083:Renin
angiotensin II; infantile hemangiomas; propranolol gel; renin; vascular endothelial growth factor