[Diagnosis and Treatment of Leptomeningeal Metastasis in Non-small Cell Lung Cancer].
Leptomeningeal metastasis (LM) is one of the disastrous events in managing advanced non-small cell lung cancer (NSCLC) due to severe clinical symptoms and a grave prognosis. Although intrathecal (IT) chemotherapy show some effects for LM in advanced NSCLC, the prognosis is still poor (12 wk-14 wk). A large majority (84%-97%) of the patients were found to have adenocarcinoma histology. Epidermal growth factor receptor (EGFR) senstive mutations were detected in 43.0%-70.5% adenocarcinoma patients with LM. EGFR tyrosine kinase inhibitors (TKIs) showed to be effective for LM in selected NSCLC patients in some reseaches, and confer a survival benefit. Furthermore, future trials need be done to determine the effect of EGFR-TKIs treatment in NSCLC-LM patients.
Department of Respiratory Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Science  ＆ Peking Union Medical College, Beijing 100730, China.
Yan
Y
Xu
Department of Respiratory Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Science  ＆ Peking Union Medical College, Beijing 100730, China.
Longyun
L
Li
Department of Respiratory Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Science  ＆ Peking Union Medical College, Beijing 100730, China.
Mengzhao
M
Wang
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary; D009362:Neoplasm Metastasis
D000970:Antineoplastic Agents