Integrated physiologic assessment of ischemic heart disease in real-world practice using index of microcirculatory resistance and fractional flow reserve: insights from the International Index of Microcirculatory Resistance Registry.
BACKGROUND
The index of microcirculatory resistance (IMR) is a quantitative and specific index for coronary microcirculation. However, the distribution and determinants of IMR have not been fully investigated in patients with ischemic heart disease (IHD).


RESULTS
Consecutive patients who underwent elective measurement of both fractional flow reserve (FFR) and IMR were enrolled from 8 centers in 5 countries. Patients with acute myocardial infarction were excluded. To adjust for the influence of collateral flow, IMR values were corrected with Yong's formula (IMRcorr). High IMR was defined as greater than the 75th percentile in each of the major coronary arteries. FFR≤0.80 was defined as an ischemic value. 1096 patients with 1452 coronary arteries were analyzed (mean age 61.1, male 71.2%). Mean FFR was 0.84 and median IMRcorr was 16.6 U (Q1, Q3 12.4 U, 23.0 U). There was no correlation between IMRcorr and FFR values (r=0.01, P=0.62), and the categorical agreement of FFR and IMRcorr was low (kappa value=-0.04, P=0.10). There was no correlation between IMRcorr and angiographic % diameter stenosis (r=-0.03, P=0.25). Determinants of high IMR were previous myocardial infarction (odds ratio [OR] 2.16, 95% confidence interval [CI] 1.24-3.74, P=0.01), right coronary artery (OR 2.09, 95% CI 1.54-2.84, P<0.01), female (OR 1.67, 95% CI 1.18-2.38, P<0.01), and obesity (OR 1.80, 95% CI 1.31-2.49, P<0.01). Determinants of FFR ≤0.80 were left anterior descending coronary artery (OR 4.31, 95% CI 2.92-6.36, P<0.01), angiographic diameter stenosis ≥50% (OR 5.16, 95% CI 3.66-7.28, P<0.01), male (OR 2.15, 95% CI 1.38-3.35, P<0.01), and age (per 10 years, OR 1.21, 95% CI 1.01-1.46, P=0.04).


CONCLUSIONS
IMR showed no correlation with FFR and angiographic lesion severity, and the predictors of high IMR value were different from those for ischemic FFR value. Therefore, integration of IMR into FFR measurement may provide additional insights regarding the relative contribution of macro- and microvascular disease in patients with ischemic heart disease.


BACKGROUND
URL: http://www.clinicaltrials.gov. Unique identifier: NCT02186093.
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Joo Myung
JM
Lee
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Jamie
J
Layland
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Ji-Hyun
JH
Jung
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Hyun-Jung
HJ
Lee
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Mauro
M
Echavarria-Pinto
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Stuart
S
Watkins
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Andy S
AS
Yong
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Joon-Hyung
JH
Doh
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Chang-Wook
CW
Nam
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Eun-Seok
ES
Shin
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.). bkkoo@snu.ac.kr.
Bon-Kwon
BK
Koo
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Martin K
MK
Ng
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Javier
J
Escaned
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
William F
WF
Fearon
From the Department of Medicine, Seoul National University Hospital, Seoul, South Korea (J.M.L., J.-H.J., H.-J.L., B.-K.K.); Department of Cardiology, West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, United Kingdom (J.L., S.W., K.G.O.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.W., K.G.O.); Servicio de Cardiología, Hospital Clinico San Carlos, Faculty of Medicine Complutense University of Madrid, Madrid, Spain (M.E.-P., J.E.); Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.E.-P., J.E.); Department of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA (A.S.Y., W.F.F.); Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.); Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (C.-W.N.); Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea (E.-S.S.); Institute on Aging, Seoul National University, Seoul, South Korea (B.K.K.); and Departments of Cardiology, Royal Prince Alfred and Concord Hospitals and University of Sydney, Sydney, Australia (M.K.N.).
Keith G
KG
Oldroyd
D000368:Aged; D003097:Collateral Circulation; D003251:Constriction, Pathologic / Q000175:diagnosis*; D003331:Coronary Vessels / Q000378:metabolism* / Q000473:pathology; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D014655:Vascular Resistance
coronary artery disease; fractional flow reserve; ischemic heart disease; microcirculation; physiology