Malnutrition and Gut Flora Dysbiosis: Specific Therapies for Emerging Comorbidities in Heart Failure.
Chronic heart failure is a complicated multifactorial disease with wide-spread social-economic consequences. In spite of the recent development of new drugs and therapeutic strategies, CHF-related mortality and morbidity remain high. Recent evidence suggests that changes in organs such as skeletal muscle and gut flora may play an important and independent role in CHF prognosis. This paper illustrates these phenomena, proposing how to identify them and presenting current therapies which treat organs all too often underestimated but which have a fundamental role in worsening CHF.
"S. Maugeri Foundation" IRCCS, Medical Centre, Lumezzane, 25065 Brescia, Italy.
Evasio
E
Pasini
Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.
Roberto
R
Aquilani
Division of Human Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, 25124 Brescia, Italy.
Giovanni
G
Corsetti
Department of Internal Medicine, University of Milan, 20100 Milan, Italy.
Francesco S
FS
Dioguardi
D000818:Animals; D002908:Chronic Disease; D064806:Dysbiosis / Q000150:complications / Q000382:microbiology / Q000628:therapy; D000069196:Gastrointestinal Microbiome; D006333:Heart Failure / Q000150:complications / Q000382:microbiology / Q000628:therapy; D006801:Humans; D044342:Malnutrition / Q000150:complications / Q000382:microbiology / Q000628:therapy