Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe.
Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.
Discipline of Medicine, Memorial University of Newfoundland, St John's, Canada. Electronic address: ross.feldman@med.mun.ca.
Ross D
RD
Feldman
Department of Life and Physical Sciences, Fisk University, Nashville, TN, USA.
Lee E
LE
Limbird
D000450:Aldosterone / Q000378:metabolism*; D006801:Humans; D011960:Receptors, Estrogen / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
C109584:GPER1 protein, human; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled; D000450:Aldosterone
GPCR; GPER; aldosterone; estrogen