Short-course postpartum (6-h) magnesium sulfate therapy in severe preeclampsia.
OBJECTIVE
To assess the efficacy of short-course postpartum (6-h) magnesium sulfate therapy versus 24-h conventional magnesium sulfate therapy in severe preeclampsia.


METHODS
Cases of severe preeclampsia were randomly allocated to group A (n = 76) and group B (n = 43). Group A and group B received magnesium sulfate loading dose (4 g) followed by infusion for 6 and 24 h postpartum (1 gm/h), respectively. Cases in both the groups were monitored closely after the initiation of therapy. t test and Chi-square test were used for data analysis.


RESULTS
No occurrence of convulsions was noted in both group A and group B. The mean amount of magnesium sulfate used in the study group was 15.1 ± 5.4 g as against 42.3 ± 7.3 g in controls. The duration of Foley catheterization and monitoring was significantly less in group A (mean 11.3 ± 5.1 and 11.1 ± 4.9 h, respectively) as compared to group B (mean 38.3 ± 7.3 and 38.4 ± 7.2 h, respectively). The mean duration of hospital stay was 2.7 ± 0.7 days in cases delivered vaginally and 7.5 ± 1.6 days in those who underwent cesarean section in group A, while it was 4.04 ± 1.47 and 11.11 ± 3.14 days, respectively, in group B.


CONCLUSIONS
Short-course, i.e., 6-h, postpartum magnesium sulfate therapy is as effective as conventional 24-h postpartum magnesium sulfate therapy in preventing convulsions in severe preeclampsia.
Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India. shahanjum73@gmail.com.
Shaheen
S
Anjum
Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
Gade Pramod
GP
Rajaram
Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
Imam
I
Bano
D000284:Administration, Oral; D000328:Adult; D002585:Cesarean Section; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000473:pathology; D011247:Pregnancy; D012720:Severity of Illness Index; D013997:Time Factors; D015149:Tocolytic Agents / Q000008:administration & dosage*; D016896:Treatment Outcome
D015149:Tocolytic Agents; D008278:Magnesium Sulfate
Magnesium sulfate; Occurrence of convulsion; Severe preeclampsia; Zuspan’s regimen