[THE ROLE OF HYDROGEN SULFIDE IN REGULATION OF CIRCULATION BLOOD LIVER].
It was shown in acute experiments on laboratory rats that intraportalinjectionof hydrogen sulfide's precursor L-cysteine (15 mg/kg)caused dilatation of the intrahepatic vessels. As a result, systemic blood pressure (SBP) and blood pressure in the portal vein (PVP) significantly decreased on 17,6 and 24,5%, respectively, and the rate of local blood flow in the liver (LF) and its blood filling (BF) increased on 28,2 and 24,4% respectively. Application of hydrogen sulfide donor NaHS (7 mg/kg) resulted in similarly directed changes: SBP and PVP decreased on 20,8% i 26,2% respectively,LF and BF increased on 16,4% and 30,9% respectively. Application of L-cysteine in the conditions of tsystationin-gamma-lyase blockade by LD-proparhilhlitsyn led to an increase in SBP on 20,4 % and PVP on 26,6% and a decrease of BF on 21,5% and LF in the liver on 11,7% comparing with baseline values of these parameters. So, blockade of tsystationin-gamma-lyase not only completely removed the effects of L-cysteine, but also inhibited synthesis of H2S from its endogenous predecessors,which led to vasoconstriction of liver's blood vessels and, consequently, to an increase of blood pressure and a decrease of liver blood flow rat's and volume of blood deposited in liver.
P I
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Yanchuk
L A
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Slobodianyk
D000480:Alkynes / Q000494:pharmacology; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003542:Cystathionine gamma-Lyase / Q000037:antagonists & inhibitors; D003545:Cysteine / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D006862:Hydrogen Sulfide / Q000378:metabolism*; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D008102:Liver Circulation / Q000187:drug effects* / Q000502:physiology; D017082:Portal Pressure / Q000187:drug effects* / Q000502:physiology; D011169:Portal Vein / Q000187:drug effects; D017208:Rats, Wistar; D013440:Sulfides / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D000480:Alkynes; D013440:Sulfides; C009055:propargylglycine; D003542:Cystathionine gamma-Lyase; C025451:sodium bisulfide; D003545:Cysteine; D005998:Glycine; D006862:Hydrogen Sulfide