Association between a functional genetic polymorphism (rs2230199) and age-related macular degeneration risk: a meta-analysis.
The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies. The aim of this study was to perform a meta-analysis of all available studies on this SNP in relation to AMD. The comprehensive databases of PubMed, Medline, Web of Knowledge, CNKI, and Google Scholar were searched for case-control studies investigating the association between the rs2230199 polymorphism and AMD susceptibility. ORs with 95%CIs were estimated to assess the association. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed. A total of 15 published studies including 5593 cases and 5181 controls were used in this meta-analysis. Overall, the rs2230299 SNP was significantly associated with the risk of AMD in the overall population under the additive model (OR = 1.571, 95%CI = 1.414-1.745, P = 0.000), dominant model (OR = 1.681, 95%CI = 1.521-1.858, P = 0.000), and allelic model (OR = 1.597, 95%CI = 1.470-1.734, P = 0.000). In the subgroup analysis by ethnicity, the same results were found in Caucasian populations, while no significant correlations were found in Asian populations for all comparison models. In conclusion, our meta-analysis provides evidence that the rs2230199 polymorphism contributes to the development of AMD. Further large-scale multicenter epidemiological studies are warranted to confirm this finding.
School of Life Sciences, Northwest University, Xi'an, China.
M X
MX
Zhang
The Military Area General Armed Police Hospital, Beijing, China.
X F
XF
Zhao
School of Life Sciences, Northwest University, Xi'an, China.
Y C
YC
Ren
National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.
T T
TT
Geng
School of Life Sciences, Northwest University, Xi'an, China.
H
H
Yang
National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.
T
T
Feng
School of Life Sciences, Northwest University, Xi'an, China tianbojin1975@163.com.
T B
TB
Jin
School of Life Sciences, Northwest University, Xi'an, China.
C
C
Chen
D000483:Alleles; D016022:Case-Control Studies; D003176:Complement C3 / Q000235:genetics*; D030541:Databases, Genetic; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D003176:Complement C3