Undiscovered regions on the molecular landscape of flagellar assembly.
The bacterial flagellum is a motility structure and one of the most complicated motors in the biosphere. A flagellum consists of several dozens of building blocks in different stoichiometries and extends from the cytoplasm to the extracellular space. Flagellar biogenesis follows a strict spatio-temporal regime that is guided by a plethora of flagellar assembly factors and chaperones. The goal of this review is to summarize our current structural and mechanistic knowledge of this intricate process and to identify the undiscovered regions on the molecular landscape of flagellar assembly.
LOEWE Center for Synthetic Microbiology & Department of Chemistry, Philipps University Marburg, Hans-Meerwein-Strasse, C7, 35043 Marburg, Germany.
Florian
F
Altegoer
LOEWE Center for Synthetic Microbiology & Department of Chemistry, Philipps University Marburg, Hans-Meerwein-Strasse, C7, 35043 Marburg, Germany. Electronic address: gert.bange@synmikro.uni-marburg.de.
Gert
G
Bange
D000595:Amino Acid Sequence; D001419:Bacteria / Q000378:metabolism* / Q000648:ultrastructure*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D005407:Flagella / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure*; D015964:Gene Expression Regulation, Bacterial; D018832:Molecular Chaperones / Q000378:metabolism
D001426:Bacterial Proteins; D018832:Molecular Chaperones