[Analgesic effect of fentanyl in neonates during mechanical ventilation].
OBJECTIVE
To study the analgesic effect and safety of fentanyl in neonates receiving mechanical ventilation.


METHODS
Thirty neonates receiving mechanical ventilation between December 2010 and February 2011 were randomized into drug intervention group and control group (n=15 each). In addition to the conventional treatment for both groups, the drug intervention group received fentanyl as the analgesic treatment. Heart rate, respiratory rate, blood pressure changes, and premature infant pain profile (PIPP) score before treatment and at 30 minutes, 2 hours, and 4 hours after treatment were recorded in both groups. Follow-up visits were performed for these infants after discharge, and the CDCC intellectual development scale for infants was applied to measure mental development index (MDI) and psychomotor development index (PDI) at 3, 6, 9, and 12 months of age.


RESULTS
The respiratory rate and heart rate decreased in the drug intervention group after fentanyl treatment compared with the control group (P<0.05), and the PIPP scores in the drug intervention group was significantly lower than in the control group (P<0.05). The results of follow-up visits showed no significant differences in MDI and PDI at 3, 6, 9 and 12 months of age between the drug intervention and control groups (P>0.05).


CONCLUSIONS
Fentanyl can relieve the pain response in neonates receiving mechanical ventilation, with no long-term adverse effects on neurodevelopment.
Department of Neonatology, Guiyang Maternity and Child Care Hospital, Guiyang 550003, China. liulingped@sina.com.
Shu-Shu
SS
Chen
Ling
L
Liu
Pin
P
Hu
Bi-Zhen
BZ
Shi
Yi-Kang
YK
Fu
Rui
R
Luo
Cai
C
Xie
D000701:Analgesics, Opioid / Q000494:pharmacology*; D002657:Child Development / Q000187:drug effects; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012119:Respiration / Q000187:drug effects; D012121:Respiration, Artificial
D000701:Analgesics, Opioid; D005283:Fentanyl