New guanidine-containing nanocomposites impeding the growth of Staphylococcus epidermidis 33 and the biofilm formation.
New water-soluble nanocomposites (AgNCs) based on Ag and copolymers of 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride with N-vinylpyrrolidone [poly(AGC-VP)] and vinylacetate [poly(AGC-VA)] have been developed. Antibacterial action of new silver nanocomposites on S. epidermidis 33 (planctonic cells and biofilms) is reported in this study. AgNCs strongly inhibited biofilms formation of S. epidermidis 33. The viability of S. epidermidis 33 cells in biofilms was considerably reduced by new AgNCs. It has been shown that S. epidermidis 33 inactivation in biofilms occurs at AgNC concentrations > 5 times higher as compared to those inhibiting completely the planktonic cells. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 630-638, 2016.
Institute of Technical Chemistry, Ural Branch of Russian Academy of Sciences, Laboratory of Biologically Active Compounds, Korolev Str. 3, Perm, 614013, Russia.
Marina
M
Gorbunova
Institute of Ecology and Genetics of Microorganisms, Ural Branch of Russian Academy of Sciences, Lenin Str. 11, Perm, 614090, Russia.
Larisa
L
Lemkina
D000818:Animals; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D019791:Guanidine / Q000494:pharmacology*; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D051379:Mice; D008826:Microbial Sensitivity Tests; D018625:Microscopy, Atomic Force; D053761:Nanocomposites / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012834:Silver / Q000494:pharmacology; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development*; D023382:Toxicity Tests, Acute
D011108:Polymers; D012834:Silver; D019791:Guanidine
S. epidermidis 33 planktonic cells; biofilms; guanidinium salt; nanocomposites