Relationship Between Myo-Inositol Supplementary and Gestational Diabetes Mellitus: A Meta-Analysis.
To determine whether myo-inositol supplement will increase the action of endogenous insulin, which is mainly measured by markers of insulin resistance such as homeostasis model assessment of insulin resistance.PubMed, Cochrane Library, Embase, and web of science were comprehensively searched using "gestational diabetes mellitus" and "myo-inositol" to identify relevant studies. Both subject headings and free texts were adopted. The methodological quality of the included studies were assessed and pooled analyzed by the methods recommended by the Cochrane collaboration.A total of 5 trials containing 513 participants were included. There was a significant reduction in aspects of gestational diabetes incidence (risk ratio [RR], 0.29; 95% confidence interval (95% CI), 0.19-0.44), birth weight (mean difference [MD], -116.98; 95% CI, -208.87 to -25.09), fasting glucose oral glucose tolerance test (OGTT) (MD, -0.36; 95% CI, -0.51 to -0.21), 1-h glucose OGTT (MD, -0.63; 95% CI, -1.01 to -0.26), 2-h glucose OGTT (MD, -0.45; 95% CI, -0.75 to -0.16), and related complications (odds ratio [OR], 0.28; 95% CI 0.14-0.58).On the basis of current evidence, myo-inositol supplementation reduces the development of gestational diabetes mellitus (GDM), although this conclusion requires further evaluation in large-scale, multicenter, blinded randomized controlled trials.
From the Daoshan road 18, Gulou District, Department of Obstetrics and Gynecology, Fujian Provincial Maternal and Child Health Hospital, Fujian Medical University Teaching Hospital, Fuzhou 350000, Fujian, China.
Xiangqin
X
Zheng
Zhaozhen
Z
Liu
Yulong
Y
Zhang
Yuan
Y
Lin
Jianrong
J
Song
Lianghui
L
Zheng
Sheng
S
Lin
D016640:Diabetes, Gestational / Q000188:drug therapy*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007294:Inositol / Q000627:therapeutic use*; D011247:Pregnancy; D014803:Vitamin B Complex / Q000627:therapeutic use*
D014803:Vitamin B Complex; D007294:Inositol