Maternal antibodies and developing blood-brain barrier.
We briefly review the protective role of maternal antibodies during fetal development and at early postnatal stages. We describe antibody delivery to fetuses, particularly in the context of the developing blood-brain barrier (BBB), and present the essential concepts regarding the adult BBB, together with existing information on the prenatal developing BBB. We focus on maternal antibody transfer to the developing brain and the consequences of the presence of pathogenic antibodies at early stages of brain development on subsequent brain dysfunction.
The Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA. Czhkowal@gmail.com.
Czeslawa
C
Kowal
The Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Andrew
A
Athanassiou
The Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Huiyi
H
Chen
The Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.|Hofstra North Shore-LIJ School of Medicine, 500 Hofstra University, Hempstead, NY, 11549, USA.
Betty
B
Diamond
D000328:Adult; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000378:metabolism*; D000920:Antibody-Dependent Cell Cytotoxicity; D001812:Blood-Brain Barrier / Q000276:immunology*; D001921:Brain / Q000196:embryology / Q000276:immunology*; D001927:Brain Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy
D000906:Antibodies
Autoimmunity; Developing blood–brain barrier; Maternal antibodies; Neuroimmunology