Three new sativene sesquiterpenoids from cultures of endophytic fungus Bipolaris eleusines.
Three new sativene sesquiterpenoids, bipolenins A-C (1-3), together with two known analogs (4 and 5), were obtained from cultures of endophytic fungus Bipolaris eleusines. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound 2 showed weak inhibitory activities against lung cancer A-549 and breast cancer MCF-7 with IC50 values of 33.2 and 19.1 μmol, respectively.
a School of Agriculture and Biological Technic, Yunnan Agricultural University , Kunming 650201 , China.
Hong-Lian
HL
Ai
a School of Agriculture and Biological Technic, Yunnan Agricultural University , Kunming 650201 , China.
Man-Si
MS
Yang
a School of Agriculture and Biological Technic, Yunnan Agricultural University , Kunming 650201 , China.
Shu-Hui
SH
Zi
b Root and Tuber Crop Institute of Yunnan Agricultural University , Kunming 650201 , China.
Hua-Chun
HC
Guo
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C000604669:bipolenin A; C000604670:bipolenin B; C000604671:bipolenin C; C430146:sativene
Bipolaris eleusines; cytotoxicity; endophytic fungus; sativene sesquiterpenoids