Shigella Infections in Household Contacts of Pediatric Shigellosis Patients in Rural Bangladesh.
To examine rates of Shigella infections in household contacts of pediatric shigellosis patients, we followed contacts and controls prospectively for 1 week after the index patient obtained care. Household contacts of patients were 44 times more likely to develop a Shigella infection than were control contacts (odds ratio 44.7, 95% CI 5.5-361.6); 29 (94%) household contacts of shigellosis patients were infected with the same species and serotype as the index patient's. Pulsed-field gel electrophoresis showed that 14 (88%) of 16 with infected contacts had strains that were indistinguishable from or closely related to the index patient's strain. Latrine area fly counts were higher in patient households compared with control households, and 2 patient household water samples were positive for Shigella. We show high susceptibility of household contacts of shigellosis patients to Shigella infections and found environmental risk factors to be targeted in future interventions.
Christine Marie
CM
George
Shahnawaz
S
Ahmed
Kaisar A
KA
Talukder
Ishrat J
IJ
Azmi
Jamie
J
Perin
R Bradley
RB
Sack
David A
DA
Sack
O Colin
OC
Stine
Lauren
L
Oldja
Mohammad
M
Shahnaij
Subhra
S
Chakraborty
Tahmina
T
Parvin
Sazzadul Islam
SI
Bhuyian
Edward
E
Bouwer
Xiaotong
X
Zhang
Trisheeta N
TN
Hasan
Sharmin J
SJ
Luna
Fatema
F
Akter
Abu S G
AS
Faruque
D001459:Bangladesh / Q000453:epidemiology; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D004405:Dysentery, Bacillary / Q000453:epidemiology / Q000635:transmission*; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data*; D012760:Shigella / Q000821:virology*
Bangladesh; Shigella; antibacterial drugs; bacteria; child; dysentery; enteric infections; houseflies; households; hygiene; insect vectors; sanitation; shigellosis; vector-borne infections; water quality