Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome.
This study was aimed to compare serum urocortin-3 (UCN3) levels in women with polycystic ovary syndrome (PCOS) and healthy women, and establish what role UCN3 levels play in PCOS. Fifty-two patients with PCOS and 55 healthy women were included in the study, matched for age and body mass index. Fasting blood glucose (FBG), insulin, hs-CRP, UCN3 and free-testosterone levels of the all participants were measured. HOMA-IR was used to calculate the insulin resistance. Circulating UCN3 levels were significantly increased in women with PCOS than in control subjects (54.49 ± 5.77 versus 51.28 ± 5.86 pmol/l, p = 0.005). Serum insulin, hs-CRP and HOMA-IR levels were higher in women with PCOS than in control group. UCN3 levels positively correlated with hs-CRP in PCOS group (r = 0.391, p = 0.004). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curves were 0.732 (95% CI 0.634-0.830, p < 0.001) for UCN3 levels. The optimal cut-off value of UCN3 for detecting PCOS was ≥51.46 pmol/l, at which the sensitivity was 75% and specificity was 68%. Our results suggest that there is a potential link between PCOS and UCN3 levels. The results of this study support the presence of increased UCN3 levels for the association of inflammation with PCOS.
a Department of Obstetrics and Gynecology , Manisa Merkezefendi State Hospital , Manisa , Turkey .
Muzaffer
M
Temur
b Department of Obstetrics and Gynecology , Manisa Merkezefendi State Hospital and Manisa Akhisar State Hospital , Manisa , Turkey .
Özgür
Ö
Yilmaz
c Department of Medical Biochemistry , İzmir Katipcelebi University Medical School , İzmir , Turkey .
Saliha
S
Aksun
d Department of Obstetrics and Gynecology , Aydın Obstetrics and Pediatrics Hospital , Aydın , Turkey .
Pelin
P
Özün Özbay
e Department of Endocrinology , İzmir Bozyaka Education and Research Hospital , İzmir , Turkey .
Mehmet
M
Calan
f Department of Medical Biochemistry , Dokuz Eylul University Medical School , Izmir , Turkey .
Tuncay
T
Küme
g Department of Obstetrics and Gynecology , Silivri State Hospital , İstanbul , Turkey , and.
Murat
M
Karakulak
h Division of Pediatric Endocrinology , Dr Behçet Uz Children Research and Training Hospital , İzmir , Turkey.
Hüseyin Anıl
HA
Korkmaz
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003346:Corticotropin-Releasing Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012372:ROC Curve; D054832:Urocortins / Q000097:blood*; D055815:Young Adult
C426704:UCN3 protein, human; D054832:Urocortins; D003346:Corticotropin-Releasing Hormone
PCOS; hs-CRP; insulin; urocortin-3