Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis.
Plaque rupture, usually of a precursor lesion known as a 'vulnerable plaque' or 'thin-cap fibroatheroma', is the leading cause of thrombosis. Less-frequent aetiologies of coronary thrombosis are erosion, observed with greatest incidence in women aged <50 years, and eruptive calcified nodules, which are occasionally identified in older individuals. Various treatments for patients with coronary artery disease, such as CABG surgery and interventional therapies, have led to accelerated atherosclerosis. These processes occur within months to years, compared with the decades that it generally takes for native disease to develop. Morphological identifiers of accelerated atherosclerosis include macrophage-derived foam cells, intraplaque haemorrhage, and thin fibrous cap. Foam-cell infiltration can be observed within 1 year of a saphenous vein graft implantation, with subsequent necrotic core formation and rupture ensuing after 7 years in over one-third of patients. Neoatherosclerosis occurs early and with greater prevalence in drug-eluting stents than in bare-metal stents and, although rare, complications of late stent thrombosis from rupture are associated with high mortality. Comparison of lesion progression in native atherosclerotic disease, atherosclerosis in saphenous vein grafts, and in-stent neoatherosclerosis provides insight into the pathogenesis of atheroma formation in natural and iatrogenic settings.
CVPath Institute, Inc., 19 Firstfield Road, Gaithersburg, MD 20878, USA.
Kazuyuki
K
Yahagi
CVPath Institute, Inc., 19 Firstfield Road, Gaithersburg, MD 20878, USA.
Frank D
FD
Kolodgie
CVPath Institute, Inc., 19 Firstfield Road, Gaithersburg, MD 20878, USA.
Fumiyuki
F
Otsuka
Department of Medicine, Emory University Hospital, 550 Peachtree Street, Nebraska, Atlanta, GA 30308, USA.
Aloke V
AV
Finn
CVPath Institute, Inc., 19 Firstfield Road, Gaithersburg, MD 20878, USA.
Harry R
HR
Davis
CVPath Institute, Inc., 19 Firstfield Road, Gaithersburg, MD 20878, USA.
Michael
M
Joner
CVPath Institute, Inc., 19 Firstfield Road, Gaithersburg, MD 20878, USA.
Renu
R
Virmani
D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000209:etiology / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology*; D023903:Coronary Restenosis / Q000209:etiology / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology*; D018450:Disease Progression; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D058226:Plaque, Atherosclerotic / Q000473:pathology* / Q000503:physiopathology*; D015995:Prevalence; D012501:Saphenous Vein / Q000473:pathology*; D015996:Survival Rate; D014481:United States / Q000453:epidemiology