[Preliminary data on the effectiveness of resveratrol in a new formulation in treatment of hot flushes].
OBJECTIVE
We conducted a pilot study to evaluate the effectiveness of resveratrol absorbed orally, conveyed through a new patented technology that increases the absorption through the oral mucosa in treatment of hot flushes (HF) during menopause.


METHODS
This is a randomized controlled double-blind study with crossover design. From October 2012 to July 2014 we considered the first 50 patients enrolled at the Center for Menopause Maggiore Hospital of Charity of Novara, with diagnosis of physiological or surgical menopause. Each woman received a diary in which she indicated the weekly number of HF and the perceived intensity, in a 0-10 Scale (Visual Analogue Scale, VAS).


RESULTS
Reduction of the monthly number of vasomotor episodes. Resveratrol 16/28 (57.1%); P2/22 placebo (9.1%) <0.001. The resveratrol group gets a positive result 6.28 times more compared to the placebo arm (95% CI: 1.61-24.49). Improvement of the intensity of symptoms and improving quality of life: resveratrol 22/28 (78.6%); placebo 4/22 P (18.2%) <0.001. Resveratrol group obtained a positive result 4:32 times more than the placebo arm (95% CI: 1.74-10.71).


CONCLUSIONS
Resveratrol is effective in reducing the number of episodes vasomotor and the intensity of HF, with the transition from moderate/severe to mild symptoms in 78.6% of patients. Resveratrol has the characteristics to be an alternative therapy in the treatment of HF in menopause.
Struttura Complessa di Ginecologia e Ostetricia, AUSL della Valle d'Aosta, Aosta, Italia - lleo@ausl.vda.it.
L
L
Leo
D
D
Surico
F
F
Deambrogio
A
A
Scatuzzi
P
P
Marzullo
R
R
Tinelli
C
C
Molinari
N
N
Surico
D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D007558:Italy; D008593:Menopause; D008875:Middle Aged; D010865:Pilot Projects; D011788:Quality of Life; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D016896:Treatment Outcome
D013267:Stilbenes; D000077185:Resveratrol