Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls.
OBJECTIVE
The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect the early stages of autoimmune gastrointestinal diseases, such as Crohn's disease, ulcerative colitis and coeliac disease in patients with psoriasis.


METHODS
This was a hospital-based case-control study. Patients with chronic plaque psoriasis were included as cases. The control group consisted of patients with other skin diseases and who complied with the same selection criteria as cases. Two controls were selected per one case. We analysed the following antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, tTG, AGA) and non-specific signs of gastrointestinal diseases.


RESULTS
There were significant differences between cases and controls in several parameters. Leucocyte count, CRP, total protein, transglutaminase IgA antibodies and p-ANCA were statistically significant between groups (P < 0.05). In the binary logistic model, leucocyte count and p-ANCA (for all parameters included in the logistic model P ≤ 0.001) were associated with psoriasis.


CONCLUSIONS
Patients with psoriasis should be regularly screened for coeliac and inflammatory bowel disease. Early diagnosis of gastrointestinal diseases and risk factors may prevent complications and greatly improve the patient's quality of life.
Department of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic.|Department of Epidemiology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic.
Katerina
K
Juzlova
Department of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic.|Department of Epidemiology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic.
Jana
J
Votrubova
Department of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic.|Department of Epidemiology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic.
Martina
M
Dzambova
Department of Epidemiology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic.
Dana
D
Gopfertova
Department of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic.
Jana
J
Hercogova
Department of Epidemiology, 2nd Faculty of Medicine, Charles University in Prague, Czech Republic.
Zdenek
Z
Smerhovsky
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D018153:Czech Republic / Q000453:epidemiology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007958:Leukocyte Count; D008297:Male; D011565:Psoriasis / Q000150:complications* / Q000453:epidemiology; D011788:Quality of Life; D011503:Transglutaminases / Q000378:metabolism
D019268:Antibodies, Antineutrophil Cytoplasmic; D007070:Immunoglobulin A; D002097:C-Reactive Protein; D011503:Transglutaminases
coeliac disease; inflammatory bowel diseases; psoriasis