Caerulomycin A inhibits Th2 cell activity: a possible role in the management of asthma.
We have recently demonstrated that Caerulomycin A induces regulatory T cells differentiation by suppressing Th1 cells activity. The role of regulatory T cells is well established in suppressing the function of Th2 cells. Th2 cells are known to inflict the induction of the activation of asthma. Consequently, in the present study, we monitored the influence of Caerulomycin A in inhibiting the activity of Th2 cells and its impact in recuperating asthma symptoms. Interestingly, we observed that Caerulomycin A significantly suppressed the differentiation of Th2 cells, as evidenced by downregulation in the GATA-3 expression. Further, decline in the levels of IL-4, IL-5 and IL-13 cytokines and IgE was noted in the animals suffering from asthma. Furthermore, we noticed substantial suppression in the inflammatory response and number of eosinophils in the lungs. In essence, this study signifies an important therapeutic role of Caerulomycin A in asthma.
Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh-160036, INDIA.
Weshely
W
Kujur
Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh-160036, INDIA.
Rama Krishna
RK
Gurram
Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh-160036, INDIA.
Nazia
N
Haleem
Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh-160036, INDIA.
Sudeep K
SK
Maurya
Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh-160036, INDIA.
Javed N
JN
Agrewala
D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005260:Female; D050990:GATA3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007958:Leukocyte Count; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000276:immunology*; D051379:Mice; D011725:Pyridines / Q000494:pharmacology*; D012720:Severity of Illness Index; D018418:Th2 Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D050990:GATA3 Transcription Factor; D011725:Pyridines; C544423:caerulomycin A; D007073:Immunoglobulin E