Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?
Innate immunity serves as the frontline defence against invading pathogens. Despite decades of research, new insights are constantly challenging our understanding of host-elicited immunity during microbial infections. Recently, two families of humoral innate immune proteins, pentraxins and collectins, have become a major focus of research in the field of innate immunity. Pentraxins and collectins are key players in activating the humoral arm of innate immunity, taking centre stage in immunoregulation and disease modulation. However, increasing evidence suggests that pentraxins and collectins can also mediate pathogenic effects during some infections. Herein, we discuss the protective and pathogenic effects of pentraxins and collectins, as well as their therapeutic significance.
Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia.
Suan-Sin
SS
Foo
WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.
Patrick C
PC
Reading
Humanitas Clinical and Research Center, Department of Inflammation and Immunology, 20089, Rozzano, Milano, Italy.
Sébastien
S
Jaillon
Humanitas Clinical and Research Center, Department of Inflammation and Immunology, 20089, Rozzano, Milano, Italy; Humanitas University, 20089, Rozzano, Milano, Italy.
Alberto
A
Mantovani
Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia. Electronic address: s.mahalingam@griffith.edu.au.
Suresh
S
Mahalingam
D001424:Bacterial Infections / Q000276:immunology; D002097:C-Reactive Protein / Q000276:immunology* / Q000627:therapeutic use; D037222:Collectins / Q000276:immunology* / Q000627:therapeutic use; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D056724:Immunity, Humoral; D007113:Immunity, Innate / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D037102:Lectins / Q000276:immunology; D037601:Mannose-Binding Lectin / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D008954:Models, Biological; D037662:Pulmonary Surfactant-Associated Protein A / Q000276:immunology; D037663:Pulmonary Surfactant-Associated Protein D / Q000276:immunology; D000683:Serum Amyloid P-Component / Q000276:immunology / Q000627:therapeutic use; D000097604:Ficolins; D000099153:Pentraxins
D002097:C-Reactive Protein; D037222:Collectins; D037102:Lectins; D037601:Mannose-Binding Lectin; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D; D000683:Serum Amyloid P-Component; D000097604:Ficolins; D000099153:Pentraxins
collectins; humoral innate immunity; mannose-binding lectin; pathogens; pentraxin 3; pentraxins