Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region.
Modulation of the rhythmic activity of local field potentials (LFP) in neuronal networks could be a mechanism of deep brain stimulation (DBS). However, exact changes of LFP during the periods of high-frequency stimulation (HFS) of DBS are unclear because of the interference of dense stimulation artifacts with high amplitudes. In the present study, we investigated LFP changes induced by HFS of afferent axons in the hippocampal CA1 region of urethane-anesthetized rats by using a proper algorithm of artifact removal. Afterward, the LFP changes in the frequency bands of [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] rhythms were studied by power spectrum analysis and coherence analysis for the recorded signals collected in the pyramidal layer and in the stratum radiatum of CA1 region before, during and after 1-min long 100 and 200[Formula: see text]Hz HFS. Results showed that the power of LFP rhythms in higher-frequency band ([Formula: see text] rhythm) increased in the pyramidal layer and the power of LFP rhythms in lower-frequency bands ([Formula: see text], [Formula: see text] and [Formula: see text] rhythms) decreased in the stratum radiatum during HFS. The synchronization of [Formula: see text] rhythm decreased and the synchronization of [Formula: see text] rhythm increased during HFS in the stratum radiatum. These results suggest that axonal HFS could modulate LFP rhythms in the downstream brain areas with a plausible underlying mechanism of partial axonal blockage induced by HFS. The study provides new evidence to support the mechanism of DBS modulating rhythmic activity of neuronal populations.
* Ministry of Education Key Lab of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
Ying
Y
Yu
* Ministry of Education Key Lab of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
Zhouyan
Z
Feng
* Ministry of Education Key Lab of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
Jiayue
J
Cao
* Ministry of Education Key Lab of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
Zheshan
Z
Guo
* Ministry of Education Key Lab of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
Zhaoxiang
Z
Wang
* Ministry of Education Key Lab of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
Na
N
Hu
† Department of Biomedical Engineering, The College of New Jersey, Ewing NJ 08628, USA.
Xuefeng
X
Wei
D000465:Algorithms; D000818:Animals; D001369:Axons / Q000502:physiology*; D055592:Biophysical Phenomena / Q000502:physiology*; D056547:CA1 Region, Hippocampal / Q000166:cytology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000502:physiology*; D008297:Male; D009415:Nerve Net / Q000502:physiology; D010507:Periodicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013057:Spectrum Analysis
High-frequency stimulation; artifact removal; local field potential; power spectrum density; rhythm modulation; synchronization