Reverse Remodeling and Prognosis Following Kidney Transplantation in Contemporary Patients With Cardiac Dysfunction.
BACKGROUND
Cardiac dysfunction influences candidate selection for kidney transplantation. There is a paucity of data regarding predictors of myocardial recovery following kidney transplantation and long-term outcomes.


OBJECTIVE
The purpose of this study was to identify the extent of reverse remodeling in our kidney transplant population and the predictors of such changes, and to assess outcomes in these patients.


METHODS
We reviewed 232 patients who underwent kidney transplantation at the Cleveland Clinic from 2003 to 2013 and who had baseline and post-transplant echocardiograms; patients with simultaneous heart transplantation were excluded.


RESULTS
Post-transplantation mean left ventricular ejection fraction (LVEF) improved in those with LV dysfunction (increased from 41% to 50%; p < 0.0001; n = 66). There was significant improvement in other parameters, including diastolic function, LV end-diastolic dimension, LV mass, and right ventricular systolic pressure. After adjusting for multiple clinical variables, increased hemoglobin following transplantation was associated with an improved LVEF (odds ratio: 1.50; 95% confidence interval [CI]: 1.07 to 2.14; p = 0.016) and reduced mortality (hazard ratio [HR]: 0.65; 95% CI: 0.49 to 0.87; p = 0.004). An improved LVEF ≥10% predicted survival independently of a pre-transplantation LVEF (HR: 0.46; 95% CI: 0.21 to 0.93; p = 0.031).


CONCLUSIONS
Kidney transplantation is associated with improved cardiac structure and function. A rise in post-transplantation hemoglobin was a significant factor associated with such changes, in addition to conferring a survival advantage.
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio.
Nael
N
Hawwa
Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio.
Kevin
K
Shrestha
Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio.
Muhammad
M
Hammadah
Apex Heart Clinic, Gleneagles Hospital, Singapore.
Poh Shuan Daniel
PSD
Yeo
Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio.
Richard
R
Fatica
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio. Electronic address: tangw@ccf.org.
W H Wilson
WHW
Tang
D000328:Adult; D000368:Aged; D015897:Comorbidity; D005260:Female; D006333:Heart Failure / Q000453:epidemiology* / Q000503:physiopathology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D020257:Ventricular Remodeling
D006454:Hemoglobins
anemia; cardiorenal syndrome; heart failure; reverse remodeling