Immune cell interplay in colorectal cancer prognosis.
The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, particularly the interactions between tumour-associated cells and cells of the innate and adaptive immune system. This review will discuss the relationship between cancer associated fibroblasts and macrophages, as well as between macrophages and T cells, and demonstrate how each population may support or prevent tumour growth in a different immune environment.
Samuel E Norton, Kirsten A Ward-Hartstonge, Edward S Taylor, Roslyn A Kemp, Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand.
Samuel E
SE
Norton
Samuel E Norton, Kirsten A Ward-Hartstonge, Edward S Taylor, Roslyn A Kemp, Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand.
Kirsten A
KA
Ward-Hartstonge
Samuel E Norton, Kirsten A Ward-Hartstonge, Edward S Taylor, Roslyn A Kemp, Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand.
Edward S
ES
Taylor
Samuel E Norton, Kirsten A Ward-Hartstonge, Edward S Taylor, Roslyn A Kemp, Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand.
Roslyn A
RA
Kemp
Colorectal cancer neoplasms; Fibroblasts; Immune system processes; Macrophages; T lymphocytes