Mini-review: regulation of the renal NaCl cotransporter by hormones.
The renal thiazide-sensitive NaCl cotransporter, NCC, is the major pathway for salt reabsorption in the distal convoluted tubule. The activity of this cotransporter is critical for regulation of several physiological variables such as blood pressure, serum potassium, acid base metabolism, and urinary calcium excretion. Therefore, it is not surprising that numerous hormone-signaling pathways regulate NCC activity to maintain homeostasis. In this review, we will provide an overview of the most recent evidence on NCC modulation by aldosterone, angiotensin II, vasopressin, glucocorticoids, insulin, norepinephrine, estradiol, progesterone, prolactin, and parathyroid hormone.
Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico; and Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Lorena
L
Rojas-Vega
Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico; and Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico gamba@biomedicas.unam.mx.
Gerardo
G
Gamba
D000818:Animals; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006728:Hormones / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007686:Kidney Tubules, Distal / Q000187:drug effects / Q000378:metabolism*; D018000:Receptors, Peptide / Q000187:drug effects / Q000378:metabolism; D012084:Renin-Angiotensin System; D064486:Solute Carrier Family 12, Member 3 / Q000187:drug effects / Q000378:metabolism*
D012739:Gonadal Steroid Hormones; D006728:Hormones; D018000:Receptors, Peptide; D064486:Solute Carrier Family 12, Member 3
NCC; PTH; angiotensin II; norepinephrine; prolactin