Right-Sizing Adjuvant and Neoadjuvant Clinical Trials in Breast Cancer.
I describe a simple and intuitive method for finding sample size for clinical trials in primary breast cancer based on neoadjuvant trial results and using the FDA's patient-level meta-analysis. Then I explain a problem with this method and how the problem can be remedied.
Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas. dberry@mdanderson.org.
Donald A
DA
Berry
D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D020360:Neoadjuvant Therapy