Much ado about zero.
LINE retrotransposons actively shape mammalian genomes. Denli et al. reveal a new open reading frame, ORF0, on the antisense strand of human LINE-1 encoding a small regulatory protein. This finding may represent the birth of an emerging retrotransposon gene that can adopt various fates, as it can be fused to adjacent host sequences.
Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA. Electronic address: jef.boeke@nyumc.org.
Jef D
JD
Boeke
Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, New York University Langone School of Medicine, New York, NY 10016, USA.
David
D
Fenyo
D000818:Animals; D006801:Humans; D002679:Pan troglodytes / Q000235:genetics*; D018626:Retroelements
D018626:Retroelements