Vitamin D status in psychotic disorder patients and healthy controls--The influence of ethnic background.
Vitamin D deficiency is common among patients with psychotic disorders and could be due to unknown disease mechanisms or contingent factors. However most studies are performed in chronic patients and have often failed to address the influence of ethnicity on vitamin D levels in clinical samples. We investigated serum concentrations of 25-hydroxy vitamin D (S-25 OH D) in first episode patients compared to patients with multi episodes and healthy controls; with a specific focus on differences between visible ethnic minorities and participants from the majority population. A total of 284 participants were included in this cross-sectional study. First episode patients with a DSM-IV psychotic disorder were matched on age, gender and ethnicity to participants from a multi episode patient sample (1:1) and healthy controls (1:2). We did not find any differences between either patient groups or the healthy controls, but participants from visible ethnic minorities had significantly lower S-25 OH D than participants from the majority population. This implies that S-25 OH D should be routinely measured in persons from visible ethnic minorities since low levels are associated with higher levels of depressive symptoms.
NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Ullevaal Hospital, Building 49, P.O.Box 4956 Nydalen, N-0424 Oslo, Norway. Electronic address: mari.nerhus@medisin.uio.no.
Mari
M
Nerhus
NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Ullevaal Hospital, Building 49, P.O.Box 4956 Nydalen, N-0424 Oslo, Norway.
Akiah Ottesen
AO
Berg
Hormone Laboratory, Oslo University Hospital HF, Aker Hospital, P.O.Box 4956 Nydalen, N-0424 Oslo, Norway.
Sandra Rinne
SR
Dahl
Division of Epidemiology, Norwegian Institute of Public Health, P.O.Box 4404, N-0403 Oslo, Norway.
Kristin
K
Holvik
NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Ullevaal Hospital, Building 49, P.O.Box 4956 Nydalen, N-0424 Oslo, Norway.
Erlend Strand
ES
Gardsjord
Psychiatric Division, Regional Centre for Clinical Research in Psychosis, Stavanger University Hospital HF, P-O-Box 8100, N-4068 Stavanger, Norway.
Melissa Authen
MA
Weibell
NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Ullevaal Hospital, Building 49, P.O.Box 4956 Nydalen, N-0424 Oslo, Norway.
Thomas Doug
TD
Bjella
NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Ullevaal Hospital, Building 49, P.O.Box 4956 Nydalen, N-0424 Oslo, Norway.
Ole A
OA
Andreassen
NORMENT, KG Jebsen Center for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Ullevaal Hospital, Building 49, P.O.Box 4956 Nydalen, N-0424 Oslo, Norway.
Ingrid
I
Melle
D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005006:Ethnicity / Q000523:psychology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008913:Minority Groups / Q000523:psychology*; D011618:Psychotic Disorders / Q000097:blood / Q000208:ethnology*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000208:ethnology* / Q000523:psychology; D055815:Young Adult
D014807:Vitamin D; C104450:25-hydroxyvitamin D
Calcitriol; Case-control studies; Early diagnosis; Ethnicity; Schizophrenia; Seasons