Optical Biosensors for the Detection of Pathogenic Microorganisms.
Pathogenic microorganisms are causative agents of various infectious diseases that are becoming increasingly serious worldwide. For the successful treatment of pathogenic infection, the rapid and accurate detection of multiple pathogenic microorganisms is of great importance in all areas related to health and safety. Among various sensor systems, optical biosensors allow easy-to-use, rapid, portable, multiplexed, and cost-effective diagnosis. Here, we review current trends and advances in pathogen-diagnostic optical biosensors. The technological and methodological approaches underlying diverse optical-sensing platforms and methods for detecting pathogenic microorganisms are reviewed, together with the strengths and drawbacks of each technique. Finally, challenges in developing efficient optical biosensor systems and future perspectives are discussed.
Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 plus Program), BioProcess Engineering Research Center, KAIST, Daejeon 34141, Republic of Korea.
Seung Min
SM
Yoo
Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 plus Program), BioProcess Engineering Research Center, KAIST, Daejeon 34141, Republic of Korea. Electronic address: leesy@kaist.ac.kr.
Sang Yup
SY
Lee
D001419:Bacteria / Q000302:isolation & purification* / Q000472:pathogenicity; D015374:Biosensing Techniques; D001709:Biotechnology; D015169:Colony Count, Microbial; D003124:Colorimetry; D061848:Optical Imaging; D013059:Spectrum Analysis, Raman
diagnosis; infectious disease; nanobiotechnology; optical biosensor; pathogenic microorganism