Evaluation of Salivary Levels of Pyridinoline Cross Linked Carboxyterminal Telopeptide of Type I Collagen (ICTP) in Periodontal Health and Disease.
BACKGROUND
Traditional parameters (Pocket depth, bleeding on probing, clinical attachment loss, radiographic findings) have been used for a long time for the assessment of periodontal disease conditions. However, these parameters only indicate towards the periodontal damage that has already taken place but do not give any idea regarding the current status of the periodontal health or disease. Hence, the present study is aimed at evaluating the concentration of the bone biomarker ICTP in saliva, which can give a better real time assessment of periodontal health and disease.


METHODS
Forty three patients were selected and divided into three groups based on the recorded clinical parameters of probing pocket depth, attachment loss and bleeding on probing. Group I (Healthy, n = 11), Group II (Gingivitis, n = 17), Group III (Periodontitis. n = 15). Salivary samples were collected before scaling and root planning to avoid contamination by blood. ICTP levels were evaluated in the salivary samples by using enzyme linked immunosorbent assay (ELISA).


METHODS
Kruskal Wallis test was used to compare the mean ICTP level of the three groups.


RESULTS
ICTP was detected in all the samples. Highest mean ICTP concentrations in saliva were obtained for group III (periodontitis group) and the lowest mean ICTP concentrations were seen in group I (healthy group). This suggests that the level of ICTP in saliva increases proportionally from periodontal health to diseased conditions (gingivitis & periodontitis).


CONCLUSIONS
There is a substantial increase in the salivary concentration of ICTP in chronic periodontitis patients than in gingivitis and healthy patients. Salivary ICTP levels were the maximum in chronic periodontitis patients followed by gingivitis patients and the least in healthy individuals. ICTP may be considered as a biomarker in periodontal disease progression.
Senior Resident, Department of Periodontics, SCB Dental College & Hospital , Cuttack, Odisha, India .
Debasish
D
Mishra
Professor, Department of Periodontics, Ragas Dental College & Hospital , Chennai, Tamil Nadu, India .
Sivaram
S
Gopalakrishnan
Professor, Department of Periodontics, Ragas Dental College & Hospital , Chennai, Tamil Nadu, India .
K V
KV
Arun
Professor, Department of Periodontics, Ragas Dental College & Hospital , Chennai, Tamil Nadu, India .
Tirunveli Saravanan Subu
TS
Kumar
Lecturer, Department of Periodontics, Ragas Dental College & Hospital , Chennai, Tamil Nadu, India .
Santosh
S
Devanathan
Reader, Department of Oral Medicine & Radiology, Institute of Dental Sciences , Bhubaneswar, Odisha, India .
Satya Ranjan
SR
Misra
Bone biomarkers; Periodontal disease; Salivary biomarkers