Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum.
The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B (Compounds 1 and 2) were isolated from the EtOAc crude extract of the aerial parts ofArtemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.
College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China. Electronic address: wqh693@163.com.
Qing-Hu
QH
Wang
College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
Na-Ren-Chao-Ke-Tu
NR
Han
College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
Na-Yin-Tai
NY
Dai
College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
Rong-Jun
RJ
Wu
College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
Jie-Si
JS
Wu
D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006358:Hot Temperature; D008297:Male; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011312:Pressure; D017208:Rats, Wistar
C000609397:7-methoxyapigenin-C-6-glucopyranosyl-(1-6 )-O-glucopyranoside; C000609396:7-methoxyapigenin-C-6-glucopyranosyl-(1-6)-O-arabopyranoside; D000700:Analgesics; D004187:Disaccharides; D044950:Flavanones; D047309:Flavones; D010936:Plant Extracts
Analgesic effect; Artemisa sacrorum Ledeb; Sacroroside A; Sacroroside B