ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model.
The medicinal plants Artemisia iwayomogi (A. iwayomogi) and Curcuma longa (C. longa) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM). In this study we evaluated the effect of the water extract of a mixture of A. iwayomogi and C. longa (ACE) on high-fat diet-induced metabolic syndrome in a mouse model. Four groups of C57BL/6N male mice (except for the naive group) were fed a high-fat diet freely for 10 weeks. Among these, three groups (except the control group) were administered a high-fat diet supplemented with ACE (100 or 200 mg/kg) or curcumin (50 mg/kg). Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed. ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPARγ; fatty acid synthase, FAS; sterol regulatory element-binding transcription factor-1c, SREBP-1c; and peroxisome proliferator-activated receptor alpha, PPARα). The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model.
Internal Medicine of Cardiac Vascular System, Daejeon Oriental Hospital of Daejeon University, 176-75 Daedeok-daero, Seo-gu, Daejeon 302-869, Republic of Korea.
Seong-Jong
SJ
Lee
Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 301-724, Republic of Korea.
Jong-Min
JM
Han
Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 301-724, Republic of Korea.
Jin-Seok
JS
Lee
Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 301-724, Republic of Korea.
Chang-Gue
CG
Son
Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 176-9 Daeheung-ro, Jung-gu, Daejeon 301-724, Republic of Korea.
Hwi-Jin
HJ
Im
Internal Medicine of Cardiac Vascular System, Daejeon Oriental Hospital of Daejeon University, 176-75 Daedeok-daero, Seo-gu, Daejeon 302-869, Republic of Korea.
Hyun-Kyung
HK
Jo
Internal Medicine of Cardiac Vascular System, Daejeon Oriental Hospital of Daejeon University, 176-75 Daedeok-daero, Seo-gu, Daejeon 302-869, Republic of Korea.
Ho-Ryong
HR
Yoo
Internal Medicine of Cardiac Vascular System, Daejeon Oriental Hospital of Daejeon University, 176-75 Daedeok-daero, Seo-gu, Daejeon 302-869, Republic of Korea.
Yoon-Sik
YS
Kim
Internal Medicine of Cardiac Vascular System, Daejeon Oriental Hospital of Daejeon University, 176-75 Daedeok-daero, Seo-gu, Daejeon 302-869, Republic of Korea.
In-Chan
IC
Seol