[Targeting and role of α4β7 integrin in the pathophysiology of IBD and HIV infection].
Integrins are a large family of heterodimeric cell adhesion molecules that are key regulators in multiple biological functions. They orchestrate cell-cell and cell-extracellular matrix (ECM) adhesive interactions from embryonic development to mature tissue function, and are thus involved in cell migration, proliferation, differentiation, and survival. As such, they are also involved in human diseases, such as thrombotic diseases, inflammation, cancer, fibrosis and infectious diseases. Integrins are exciting pharmacological targets because they are exposed on the cell surface. Indeed, several compounds have been developed that block integrins function, and five have been approved as therapeutic drugs for use in clinic. This review will detail the role of α4β7, an integrin of particular relevance for mucosal diseases such as IBD (inflammatory bowel disease) and also, as reported more recently, HIV infection.
Groupe immunité des muqueuses et agents pathogènes - GIMAP EA 3064, CIC 1408, Université de Saint-Étienne, Université de Lyon, Faculté de médecine Jacques Lisfranc, 15, rue Ambroise Paré, 42023 Saint-Étienne Cedex 2, France.
Alexandre
A
Girard
Groupe immunité des muqueuses et agents pathogènes - GIMAP EA 3064, CIC 1408, Université de Saint-Étienne, Université de Lyon, Faculté de médecine Jacques Lisfranc, 15, rue Ambroise Paré, 42023 Saint-Étienne Cedex 2, France.
Nicolas
N
Rochereau
Groupe immunité des muqueuses et agents pathogènes - GIMAP EA 3064, CIC 1408, Université de Saint-Étienne, Université de Lyon, Faculté de médecine Jacques Lisfranc, 15, rue Ambroise Paré, 42023 Saint-Étienne Cedex 2, France.
Xavier
X
Roblin
Groupe immunité des muqueuses et agents pathogènes - GIMAP EA 3064, CIC 1408, Université de Saint-Étienne, Université de Lyon, Faculté de médecine Jacques Lisfranc, 15, rue Ambroise Paré, 42023 Saint-Étienne Cedex 2, France.
Christian
C
Genin
Groupe immunité des muqueuses et agents pathogènes - GIMAP EA 3064, CIC 1408, Université de Saint-Étienne, Université de Lyon, Faculté de médecine Jacques Lisfranc, 15, rue Ambroise Paré, 42023 Saint-Étienne Cedex 2, France.
Stéphane
S
Paul
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D015658:HIV Infections / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D016023:Integrins / Q000037:antagonists & inhibitors* / Q000502:physiology*; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D016201:Receptors, Lymphocyte Homing / Q000502:physiology
D016023:Integrins; D016201:Receptors, Lymphocyte Homing; C071777:integrin alpha4beta7