Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones.
An improved domino hydroformylation/benzoin condensation to give α-hydroxy ketones has been developed. Easily available olefins are smoothly converted into the corresponding α-hydroxy ketones in high yields with excellent regioselectivities. Key to success is the use of a specific catalytic system consisting of a rhodium/phosphine complex and the CO2 adduct of an N-heterocyclic carbene.
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
Kaiwu
K
Dong
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock (Germany).|Institut Sciences Chimiques de Rennes, UMR 6226, CNRS-Université de Rennes "Organométalliques: Matériaux et Catalyse", Campus de Beaulieu, 35042 Rennes (France).
Rui
R
Sang
Institut Sciences Chimiques de Rennes, UMR 6226, CNRS-Université de Rennes "Organométalliques: Matériaux et Catalyse", Campus de Beaulieu, 35042 Rennes (France).
Jean-Francois
JF
Soule
Institut Sciences Chimiques de Rennes, UMR 6226, CNRS-Université de Rennes "Organométalliques: Matériaux et Catalyse", Campus de Beaulieu, 35042 Rennes (France).
Christian
C
Bruneau
Evonik Performance Materials GmbH, Paul-Baumann-Str. 1, 45772 Marl (Germany).|Lehrstuhl für Theoretische Chemie, Ruhr-Universität Bochum, 44780 Bochum (Germany).
Robert
R
Franke
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
Ralf
R
Jackstell
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock (Germany). Matthias.Beller@catalysis.de.
Matthias
M
Beller
benzoin condensation; catalysis; domino reactions; hydroformylation; olefins