Paving the way to targeting HECT ubiquitin ligases.
Microbiology, Tumor and Cell Biology (MTC) Department, and Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Tomtebodavägen 23, Stockholm 171 65, Sweden.
Giovanna
G
Zinzalla
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D013329:Structure-Activity Relationship; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004791:Enzyme Inhibitors; D044767:Ubiquitin-Protein Ligases
HECT E3 ligases; HUWE1; ITCH; MYC; NEDD4; SMURF2; protein–protein interactions