The prognostic value of CXC-chemokine receptor 2 (CXCR2) in gastric cancer patients.
BACKGROUND
CXC chemokine receptor 2 (CXCR2) has been reported to play an important role in the proliferation and invasion of gastric cancer cells. The present study aims to investigate the impact of CXCR2 expression on the overall survival (OS) of gastric cancer patients after radical resection.


METHODS
Intratumoral CXCR2 expression was evaluated with immunohistochemistry on tissue microarrays containing tumor samples of 357 gastric cancer patients from a single center. CXCR2 expression levels were correlated to clinicopathological variables and OS.


RESULTS
CXCR2 expression was mainly located in the cytoplasm of gastric carcinoma cells. High CXCR2 expression was associated with poor tumor differentiation (p = 0.021), increased tumor depth (p < 0.001), lymph node metastasis (p < 0.001), advanced TNM stage (p < 0.001) and short OS (p = 0.001). CXCR2 expression was an independent prognostic factor for OS (p = 0.001) in multivariate analysis, and could be combined with TNM stage to generate a predictive nomogram for clinical outcome in patients with gastric cancer.


CONCLUSIONS
Intratumoral CXCR2 expression is a novel independent predictor for survival in gastric cancer patients. CXCR2 might be a promising therapeutic target of postoperative adjuvant treatment.
Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. wzl7623@163.com.|Department of Gastroenterological Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. wzl7623@163.com.
Zhenglin
Z
Wang
Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. 15921120057@163.com.
Hao
H
Liu
Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. shen.zhenbin@zs-hospital.sh.cn.
Zhenbin
Z
Shen
Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. wang.xuefei@zs-hospital.sh.cn.
Xuefei
X
Wang
Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. hellboy747@sina.com.
Heng
H
Zhang
Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. qin.jing@zs-hospital.sh.cn.
Jing
J
Qin
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, PO Box 103, 138 Yi Xue Yuan Road, Shanghai, 200032, China. jjxufdu@fudan.edu.cn.
Jiejie
J
Xu
Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. sun.yihong@zs-hospital.sh.cn.
Yihong
Y
Sun
Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. qin.xinyu@zs-hospital.sh.cn.
Xinyu
X
Qin
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D023063:Receptors, Interleukin-8B / Q000378:metabolism*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
D014408:Biomarkers, Tumor; D023063:Receptors, Interleukin-8B