Multi-institutional retrospective analysis of learning curves on dosimetry and operation time before and after introduction of intraoperatively built custom-linked seeds in prostate brachytherapy.
This multi-institutional retrospective analysis examined learning curves for dosimetric parameters and operation time after introduction of intraoperatively built custom-linked (IBCL) seeds. Data from consecutive patients treated with seed implantation before and after introduction of IBCL seeds (loose seed, n = 428; IBCL seed, n = 426) were collected from 13 centers. Dose-volume histogram parameters, operation times, and seed migration rates were compared before and after introduction of IBCL seeds. At the 1-month CT analysis, no significant differences were seen in dose to 90% of prostate volume between before and after IBCL seed introduction. No learning curve for dosimetry was seen. Prostate and rectal volume receiving at least 150% of prescription dose (V150 and RV150) were higher in the loose-seed group than in the IBCL-seed group. Operation time was extended by up to 10 min when IBCL seeds were used, although there was a short learning curve of about five patients. The percentage of patients with seed migration in the IBCL-seed group was one-tenth that in the loose-seed group. Our study revealed no dosimetric demerits, no learning curve for dosimetry, and a slightly extended operation time for IBCL seeds. A significant reduction in the rate of seed migration was identified in the IBCL-seed group.
Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara 252-0329, Japan hishiyam@kitasato-u.ac.jp.
Hiromichi
H
Ishiyama
Department of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara 252-0329, Japan.
Takefumi
T
Satoh
Department of Radiology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan.
Atsunori
A
Yorozu
Department of Urology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan.
Shiro
S
Saito
Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Kou-160, Minamiumemoto-Machi, Matsuyama, Ehime 791-0280, Japan.
Masaaki
M
Kataoka
Department of Urology, National Hospital Organization Shikoku Cancer Center, Kou-160, Minamiumemoto-Machi, Matsuyama, Ehime 791-0280, Japan.
Katsuyoshi
K
Hashine
Department of Radiology, Iwate Medical University School of Medicine, Uchimaru 19-1, Morioka 020-8505, Japan.
Ryuji
R
Nakamura
Department of Urology, Iwate Medical University School of Medicine, Uchimaru 19-1, Morioka 020-8505, Japan.
Susumu
S
Tanji
Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi-Hirokoji, Kamigyoku, Kyoto 602-8566, Japan.
Koji
K
Masui
Department of Urology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi-Hirokoji, Kamigyoku, Kyoto 602-8566, Japan.
Koji
K
Okihara
Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Toshio
T
Ohashi
Department of Urology, National Hospital Organization Saitama National Hospital, 2-1 Suwa, Wakho City, Saitama 351-0102, Japan.
Tetsuo
T
Momma
Department of Radiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo 105-8461, Japan.
Manabu
M
Aoki
Department of Urology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo 105-8461, Japan.
Kenta
K
Miki
Department of Radiology, Showa University School of Medicine, Showa University Koto Toyosu Hospital, 5-1-38 Toyosu Koto-ku, Tokyo 135-0061, Japan.
Masako
M
Kato
Department of Urology, Showa University Koto Toyosu Hospital, 5-1-38 Toyosu Koto-ku, Tokyo 135-0061, Japan.
Masashi
M
Morita
Department of Radiology, Okayama University School of Medicine, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Norihisa
N
Katayama
Department of Urology, Okayama University School of Medicine, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Yasutomo
Y
Nasu
Department of Radiology, Tokushima University School of Medicine, 3-18-15 Tokushima, Kuramoto-cho, Tokushima 770-8503, Japan.
Takashi
T
Kawanaka
Department of Urology, Tokushima University School of Medicine, 3-18-15 Tokushima, Kuramoto-cho, Tokushima 770-8503, Japan.
Tomoharu
T
Fukumori
Department of Radiology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Fumitaka
F
Ito
Department of Urology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Ryoichi
R
Shiroki
Department of Radiology, Japanese Red Cross Kumamoto Hospital, 2-1-1 Higashiku Nagamine Minami, Kumamoto City 861-8520, Japan.
Yuji
Y
Baba
Department of Urology, Japanese Red Cross Kumamoto Hospital, 2-1-1 Higashiku Nagamine Minami, Kumamoto City 861-8520, Japan.
Akito
A
Inadome
Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yasuo
Y
Yoshioka
Department of Urology, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Hitoshi
H
Takayama
Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara 252-0329, Japan.
Kazushige
K
Hayakawa
D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D006801:Humans; D007430:Intraoperative Care; D059032:Learning Curve; D008297:Male; D061646:Operative Time; D011467:Prostate / Q000473:pathology / Q000528:radiation effects; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
125I; brachytherapy; intraoperatively built custom-linked seed; loose seed; low dose rate; prostate cancer