A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines.
Palladium catalysed three component cascade process, involving coupling of 2-iodobenzoates, -benzaldehydes, or acetophenones with substituted allenes and ammonium tartrate as an ammonium surrogate, provides a novel and facile route to substituted functionalised isoquinolinones and isoquinolines in good yields.
School of Chemistry, University of Leeds, Leeds, LS6 9JT, UK. r.grigg@leeds.ac.uk c.w.g.fishwick@leeds.ac.uk.
Ronald
R
Grigg
School of Chemistry, University of Leeds, Leeds, LS6 9JT, UK. r.grigg@leeds.ac.uk c.w.g.fishwick@leeds.ac.uk and Department of Chemistry, Faculty of Science at Qena, South Valley University, Qena, Egypt.
Elghareeb E
EE
Elboray
School of Chemistry, University of Leeds, Leeds, LS6 9JT, UK. r.grigg@leeds.ac.uk c.w.g.fishwick@leeds.ac.uk and Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Sunisa
S
Akkarasamiyo
School of Chemistry, University of Leeds, Leeds, LS6 9JT, UK. r.grigg@leeds.ac.uk c.w.g.fishwick@leeds.ac.uk and Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Nutthawat
N
Chuanopparat
Department of Chemistry, Faculty of Pharmacy, Mersin University, 33342, Mersin, Turkey.
H Ali
HA
Dondas
Department of Chemistry, Faculty of Science at Qena, South Valley University, Qena, Egypt.
Hussien H
HH
Abbas-Temirek
School of Chemistry, University of Leeds, Leeds, LS6 9JT, UK. r.grigg@leeds.ac.uk c.w.g.fishwick@leeds.ac.uk.
Colin W G
CW
Fishwick
Department of Chemistry, Faculty of Science at Qena, South Valley University, Qena, Egypt.
Moustafa F
MF
Aly
Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Boonsong
B
Kongkathip
Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Ngampong
N
Kongkathip