Soleus Muscle as a Surrogate for Health Status in Human Heart Failure.
We propose the hypothesis that soleus muscle function may provide a surrogate measure of functional capacity in patients with heart failure. We summarize literature pertaining to skeletal muscle as a locus of fatigue and present our recent findings, using in vivo imaging in combination with biomechanical experimentation and modeling, to reveal novel structure-function relationships in chronic heart failure skeletal muscle and gait.
1The School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia, Australia; 2Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom; 3Centre for Musculoskeletal Research, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia; 4Biomechanics Laboratory, Department of Kinesiology, Pennsylvania State University, University Park, PA; 5Advanced Heart Failure and Cardiac Transplant Service, Royal Perth Hospital, Perth, Western Australia, Australia; 6School of Physiotherapy and Exercise Science, Curtin University, Perth, Western Australia, Australia; and 7Allied Health Department, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Daniel J
DJ
Green
Fausto A
FA
Panizzolo
David G
DG
Lloyd
Jonas
J
Rubenson
Andrew J
AJ
Maiorana
D001696:Biomechanical Phenomena; D015444:Exercise / Q000502:physiology; D005221:Fatigue / Q000503:physiopathology; D005684:Gait / Q000502:physiology; D006305:Health Status Indicators; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000503:physiopathology*