Branch-Selective Alkene Hydroarylation by Cooperative Destabilization: Iridium-Catalyzed ortho-Alkylation of Acetanilides.
An iridium(I) catalyst system, modified with the wide-bite-angle and electron-deficient bisphosphine d(F) ppb (1,4-bis(di(pentafluorophenyl)phosphino)butane) promotes highly branch-selective hydroarylation reactions between diverse acetanilides and aryl- or alkyl-substituted alkenes. This provides direct and ortho-selective access to synthetically challenging anilines, and addresses long-standing issues associated with related Friedel-Crafts alkylations.
School of Chemistry, University of Bristol, Bristol, BS8 1TS (United Kingdom).
Giacomo E M
GE
Crisenza
School of Chemistry, University of Bristol, Bristol, BS8 1TS (United Kingdom).
Olga O
OO
Sokolova
School of Chemistry, University of Bristol, Bristol, BS8 1TS (United Kingdom). john.bower@bris.ac.uk.
John F
JF
Bower
acetanilides; branch selectivity; hydroarylation; iridium; phosphine ligands