Gelation Landscape Engineering Using a Multi-Reaction Supramolecular Hydrogelator System.
Simultaneous control of the kinetics and thermodynamics of two different types of covalent chemistry allows pathway selectivity in the formation of hydrogelating molecules from a complex reaction network. This can lead to a range of hydrogel materials with vastly different properties, starting from a set of simple starting compounds and reaction conditions. Chemical reaction between a trialdehyde and the tuberculosis drug isoniazid can form one, two, or three hydrazone connectivity products, meaning kinetic gelation pathways can be addressed. Simultaneously, thermodynamics control the formation of either a keto or an enol tautomer of the products, again resulting in vastly different materials. Overall, this shows that careful navigation of a reaction landscape using both kinetic and thermodynamic selectivity can be used to control material selection from a complex reaction network.
Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University , Edinburgh, Scotland, United Kingdom EH14 4AS.
Jamie S
JS
Foster
Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University , Edinburgh, Scotland, United Kingdom EH14 4AS.
Justyna M
JM
Żurek
Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University , Edinburgh, Scotland, United Kingdom EH14 4AS.
Nuno M S
NM
Almeida
Advanced Soft Matter Group, Department of Chemical Engineering, Delft University of Technology , 2628BL Delft, The Netherlands.
Wouter E
WE
Hendriksen
Advanced Soft Matter Group, Department of Chemical Engineering, Delft University of Technology , 2628BL Delft, The Netherlands.
Vincent A A
VA
le Sage
Advanced Soft Matter Group, Department of Chemical Engineering, Delft University of Technology , 2628BL Delft, The Netherlands.
Vasudevan
V
Lakshminarayanan
Chemical Crystallography, Chemistry Research Laboratory, Oxford University , Oxford, United Kingdom OX1 3TA.
Amber L
AL
Thompson
Polymers and Advanced Materials Laboratory, National Chemical Laboratory , Pune 411008, India.
Rahul
R
Banerjee
Advanced Soft Matter Group, Department of Chemical Engineering, Delft University of Technology , 2628BL Delft, The Netherlands.
Rienk
R
Eelkema
School of Engineering, University of Glasgow , Glasgow, Scotland, United Kingdom G12 8QQ.
Helen
H
Mulvana
Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University , Edinburgh, Scotland, United Kingdom EH14 4AS.
Martin J
MJ
Paterson
Advanced Soft Matter Group, Department of Chemical Engineering, Delft University of Technology , 2628BL Delft, The Netherlands.
Jan H
JH
van Esch
Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University , Edinburgh, Scotland, United Kingdom EH14 4AS.
Gareth O
GO
Lloyd