Function analysis of rs9589207 polymorphism in miR-92a in gastric cancer.
MiR-92a was identified as an essential oncogene by promoting the cell proliferation through FBXW7 in gastric cancer (GC). The function of the single nucleotide polymorphism (SNP) located in the mature region of miR-92a (rs9589207) has not been investigated. We found that rs9589207 in miR-92a was involved in the occurrence of GC by acting as a tumor protective factor and was highly associated with tumor size in GC patients instead of tumor number or metastasis in 554 GC patients and 531 cancer-free controls. Besides, the AA genotype in miR-92a could attenuate the promoting function of miR-92a in cell proliferation with an incapacitation in downregulating the expression of FBXW7. In conclusion, rs9589207 in miR-92a was highly associated with a decreased risk of GC in Chinese Han population and might serve as a novel biomarker for the disease.
Department of Clinical Laboratory, Kunshan Hospital Affiliated to Nanjing University of Chinese Medicine, Kunshan, Jiangsu, China. liuchangming313@sina.com.
Changming
C
Liu
Department of Clinical Laboratory, Kunshan Hospital Affiliated to Nanjing University of Chinese Medicine, Kunshan, Jiangsu, China.
Ying
Y
Zhang
Department of Oncological Surgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu, China.
Haijun
H
Chen
Department of Clinical Laboratory, Wujin Hospital Affiliated to Jiangsu University, Changzhou, China.|Department of General Surgery, Wujin Hospital Affiliated to Jiangsu University, Changzhou, China.
Lixing
L
Jiang
Department of Clinical Laboratory, The 359th Hospital of PLA, Zhengjiang, China.
Daping
D
Xiao
D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D044783:F-Box Proteins / Q000235:genetics / Q000378:metabolism; D000073979:F-Box-WD Repeat-Containing Protein 7; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D034622:RNA Interference; D013274:Stomach Neoplasms / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins; D044783:F-Box Proteins; D000073979:F-Box-WD Repeat-Containing Protein 7; C513273:FBXW7 protein, human; C541874:MIRN92 microRNA, human; D035683:MicroRNAs; D044767:Ubiquitin-Protein Ligases
FBXW7; Genotype; MiR-92a; SNP; Tumor growth