Synthesis and Fluorescence Properties of new Monastrol Analogs  Conjugated Fluorescent Coumarin Scaffolds.
A mild and efficient method has been used for the synthesis of ethyl 4-(3-hydroxphenyl)-6-methyl-2-thioxo-1,3-dihydroprimidine-5-carboxylate (monastrol) (2), via Biginelli reaction. Alkylation of 2 with the fluorescent coumarin 3 afforded the new thioether analog 4. Similarly, ethyl 4-(6,8-dichloro-2-oxo-2 H-chromen-3-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate (6) was prepared. The synthesized compounds are fluorescent active and show wavelength of maximum absorption (λmax) in UV or visible region in MeOH at room temperature.
Najim A
NA
Al-Masoudi
Niran J
NJ
Al-Salihi
Yossra A
YA
Marich
Timo
T
Markus
D003374:Coumarins / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*; D013871:Thiones / Q000138:chemical synthesis / Q000737:chemistry*
D003374:Coumarins; D005456:Fluorescent Dyes; D011743:Pyrimidines; D013871:Thiones; C400223:monastrol