Resistance integrons: class 1, 2 and 3 integrons.
As recently indiscriminate abuse of existing antibiotics in both clinical and veterinary treatment leads to proliferation of antibiotic resistance in microbes and poses a dilemma for the future treatment of such bacterial infection, antimicrobial resistance has been considered to be one of the currently leading concerns in global public health, and reported to widely spread and extended to a large variety of microorganisms. In China, as one of the currently worst areas for antibiotics abuse, the annual prescription of antibiotics, including both clinical and veterinary treatment, has approaching 140 gram per person and been roughly estimated to be 10 times higher than that in the United Kingdom, which is considered to be a potential area for the emergence of "Super Bugs". Based on the integrons surveillance in Guangzhou, China in the past decade, this review thus aimed at summarizing the role of integrons in the perspective of both clinical setting and environment, with the focus on the occurrence and prevalence of class 1, 2 and 3 integrons.
College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, 510640, China. 363065247@qq.com.
Yang
Y
Deng
College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, 510640, China. xuerui.bao@hotmail.com.
Xuerui
X
Bao
College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, 510640, China. robinbobo@qq.com.
Lili
L
Ji
Institute of Agro-products Processing, Anhui Academy of Agricultural Sciences, Hefei, 230031, China. 641379334@qq.com.
Lei
L
Chen
College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, 510640, China. yaner0722@hotmail.com.
Junyan
J
Liu
College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, 510640, China. harrymiao@qq.com.
Jian
J
Miao
Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, 510120, China. jyksys@126.com.
Dingqiang
D
Chen
The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China. z0rain@126.com.
Huawei
H
Bian
Guangzhou Women and Children's Medical Center, 9 Jinsui Road, Guangzhou, 510620, China. yanmeili@live.cn.
Yanmei
Y
Li
First Affiliated Hospital of Jinan University, Guangzhou, 510620, China. guangchaoyu@126.com.
Guangchao
G
Yu
D000383:Agriculture / Q000379:methods*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002681:China; D003141:Communicable Diseases / Q000188:drug therapy* / Q000662:veterinary*; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization; D006801:Humans; D032023:Integrons
D000900:Anti-Bacterial Agents