Piperazine derivatives as iron chelators: a potential  application in neurobiology.
Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects.
Univ Paris Diderot, Sorbonne Paris Cite, ITODYS, UMR 7086, CNRS, 15 rue Jean-Antoine de Baıf, 75205 Paris Cedex 13, France
S
S
Abdelsayed
N T Ha
NT
Duong
C
C
Bureau
P P
PP
Michel
E C
EC
Hirsch
J M El Hage
JM
Chahine
N
N
Serradji
D000818:Animals; D002712:Chlorides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D059290:Dopaminergic Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004622:Embryo, Mammalian; D005290:Ferric Compounds / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007502:Iron Chelating Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007700:Kinetics; D008636:Mesencephalon / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology*; D061251:Primary Cell Culture; D051381:Rats; D017208:Rats, Wistar; D013816:Thermodynamics
D002712:Chlorides; D005290:Ferric Compounds; D007502:Iron Chelating Agents; D018696:Neuroprotective Agents; D010879:Piperazines; C024555:ferric chloride