A multivariate model exploring the predictive value of demographic, adolescent, and family factors on glycemic control in adolescents with type 1 diabetes.
The current study examined how a comprehensive set of variables from multiple domains, including at the adolescent and family level, were predictive of glycemic control in adolescents with type 1 diabetes (T1D).



Participants included 100 adolescents with T1D ages 10-16 yrs and their parents. Participants were enrolled in a longitudinal study about youth decision-making involvement in chronic illness management of which the baseline data were available for analysis. Bivariate associations with glycemic control (HbA1C) were tested. Hierarchical linear regression was implemented to inform the predictive model.



In bivariate analyses, race, family structure, household income, insulin regimen, adolescent-reported adherence to diabetes self-management, cognitive development, adolescent responsibility for T1D management, and parent behavior during the illness management discussion were associated with HbA1c. In the multivariate model, the only significant predictors of HbA1c were race and insulin regimen, accounting for 17% of the variance. Caucasians had better glycemic control than other racial groups. Participants using pre-mixed insulin therapy and basal-bolus insulin had worse glycemic control than those on insulin pumps.



This study shows that despite associations of adolescent and family-level variables with glycemic control at the bivariate level, only race and insulin regimen are predictive of glycemic control in hierarchical multivariate analyses. This model offers an alternative way to examine the relationship of demographic and psychosocial factors on glycemic control in adolescents with T1D.
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.|Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shivani
S
Agarwal
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.|Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Abbas F
AF
Jawad
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. millerv@email.chop.edu.|Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. millerv@email.chop.edu.
Victoria A
VA
Miller
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D002648:Child; D003710:Demography; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy*; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012648:Self Care / Q000592:standards* / Q000706:statistics & numerical data; D012931:Social Environment; D016896:Treatment Outcome; D016903:Drug Monitoring
D001786:Blood Glucose
adolescent; diabetes mellitus; psychology; type 1