In vivo evaluation of a Ti-based bulk metallic glass alloy bar.
Ti-based bulk metallic glasses are reported with high strength, low Young modulus and high corrosion resistance, suggesting their potentials in biomedical applications. However a thorough in vivo evaluation of its biocompatibilities has not been conducted yet. In this study, we implanted bars of Ti-based bulk metallic glass in the femoral bone of rats, followed up local tissue reaction as well as its component ions' diffusion in local area and whole body. The Ti-based BMG (Ti40Zr10Cu34Pd14Sn2) alloy exhibited favorable features of both high strength and high elasticity. In vivo implant evaluation showed that it has a good tissue compatibility, equivalent bone integration and bonding ability with Ti sample. No component ion diffusion was detected up to 3 months post implantation. The possibility and efficacy of its use for bone implant is confirmed. Thus further long term implant study is recommended.
Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Ryo
R
Kokubun
Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Wei
W
Wang
Institute for Materials Research, Tohoku University, Sendai, Japan.
Shengli
S
Zhu
Institute for Materials Research, Tohoku University, Sendai, Japan.
Guoqiang
G
Xie
Department of Instrumental Analysis Research Center, Tokyo Medical and Dental University, Tokyo, Japan.
Shizuko
S
Ichinose
Department of Orthopaedic Surgery, Kawakita General Hospital, Tokyo, Japan.
Soichiro
S
Itoh
Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Kazuo
K
Takakuda
D000497:Alloys / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry* / Q000633:toxicity*; D002448:Cell Adhesion / Q000187:drug effects; D019245:Compressive Strength; D055119:Elastic Modulus; D005269:Femur / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology*; D005898:Glass / Q000737:chemistry; D006244:Hardness; D008297:Male; D008422:Materials Testing; D010012:Osteogenesis / Q000187:drug effects; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry* / Q000633:toxicity*
D000497:Alloys; D018786:Bone Substitutes; D014025:Titanium
Bulk metallic glass; Ti-based alloy; in vivo