Effective, Facile, and Selective Hydrolysis of the Chemical Warfare Agent VX Using Zr6-Based Metal-Organic Frameworks.
The nerve agent VX is among the most toxic chemicals known to mankind, and robust solutions are needed to rapidly and selectively deactivate it. Herein, we demonstrate that three Zr6-based metal-organic frameworks (MOFs), namely, UiO-67, UiO-67-NH2, and UiO-67-N(Me)2, are selective and highly active catalysts for the hydrolysis of VX. Utilizing UiO-67, UiO-67-NH2, and UiO-67-N(Me)2 in a pH 10 buffered solution of N-ethylmorpholine, selective hydrolysis of the P-S bond in VX was observed. In addition, UiO-67-N(Me)2 was found to catalyze VX hydrolysis with an initial half-life of 1.8 min. This half-life is nearly 3 orders of magnitude shorter than that of the only other MOF tested to date for hydrolysis of VX and rivals the activity of the best nonenzymatic materials. Hydrolysis utilizing Zr-based MOFs is also selective and facile in the absence of pH 10 buffer (just water) and for the destruction of the toxic byproduct EA-2192.
Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Su-Young
SY
Moon
Edgewood Chemical Biological Center, U.S. Army Research, Development, and Engineering Command , 5183 Blackhawk Road, Aberdeen Proving Ground, Maryland 21010, United States.
George W
GW
Wagner
Department of Chemistry, University of Wisconsin-Stevens Point , 2001 Fourth Avenue, Stevens Point, Wisconsin 54482, United States.
Joseph E
JE
Mondloch
Edgewood Chemical Biological Center, U.S. Army Research, Development, and Engineering Command , 5183 Blackhawk Road, Aberdeen Proving Ground, Maryland 21010, United States.
Gregory W
GW
Peterson
Edgewood Chemical Biological Center, U.S. Army Research, Development, and Engineering Command , 5183 Blackhawk Road, Aberdeen Proving Ground, Maryland 21010, United States.|Leidos, Inc. , P.O. Box 68, Gunpower, Maryland 21010, United States.
Jared B
JB
DeCoste
Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Joseph T
JT
Hupp
Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.|Department of Chemistry, Faculty of Science, King Abdulaziz University , Jeddah, Saudi Arabia.
Omar K
OK
Farha
D002619:Chemical Warfare Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D004785:Environmental Pollutants / Q000737:chemistry*; D052918:Environmental Restoration and Remediation; D006868:Hydrolysis; D063065:Organophosphonates / Q000737:chemistry*; D009946:Organothiophosphorus Compounds / Q000737:chemistry*; D011437:Propylamines / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
D002619:Chemical Warfare Agents; D056831:Coordination Complexes; D004785:Environmental Pollutants; D063065:Organophosphonates; D009946:Organothiophosphorus Compounds; D011437:Propylamines; D015040:Zirconium; C000608852:S-2-(diisopropylamino)ethyl O-hydrogen methylphosphonothioate; C009680:VX-agent