Application of Mesenchymal Stem Cells in the Targeted Gene Therapy for Gastric Cancer.
The incidence of gastric cancer is third most prevalent among all malignant tumors in China. The conventional therapies for advanced gastric cancer are futile. Targeted gene therapy has become a promising alternative approach. Mesenchymal stem cells (MSCs) can be used as potential cellular vehicles for cancer therapy in vivo. This review will summarize the published data about the application of MSC-based targeted therapy for gastric cancer, and discuss some of the challenges associated with this method.
Ya-Li
YL
Zhou
Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, 82 Cuiyingmen, Lanzhou, Gansu Province, 730030, China. liym@lzu.edu.cn.
Yu-Min
YM
Li
Wen-Ting
WT
He
D000818:Animals; D015316:Genetic Therapy; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D058990:Molecular Targeted Therapy; D013274:Stomach Neoplasms / Q000628:therapy*