Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial.
Autologous platelet concentrates represent promising innovative tools in the field of regenerative medicine and have been extensively used in oral surgery. Unlike platelet rich plasma (PRP) that is a gel or a suspension, Leukocyte-Platelet Rich Fibrin (L-PRF) is a solid 3D fibrin membrane generated chair-side from whole blood containing no anti-coagulant. The membrane has a dense three dimensional fibrin matrix with enriched platelets and abundant growth factors. L-PRF is a popular adjunct in surgeries because of its superior handling characteristics as well as its suturability to the wound bed. The goal of the study is to demonstrate generation as well as provide detailed characterization of relevant properties of L-PRF that underlie its clinical success.
Department of General Practice, School of Dentistry, Virginia Commonwealth University; madurantakap@vcu.edu.
Parthasarathy
P
Madurantakam
Department of Biomedical Engineering, Virginia Commonwealth University.
Suyog
S
Yoganarasimha
Department of Periodontics, School of Dentistry, Virginia Commonwealth University.
Fadi K
FK
Hasan
D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D001792:Blood Platelets / Q000737:chemistry* / Q000166:cytology; D005337:Fibrin / Q000737:chemistry*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry; D007962:Leukocytes / Q000737:chemistry* / Q000166:cytology; D053657:Platelet-Rich Plasma / Q000737:chemistry* / Q000166:cytology; D044968:Regenerative Medicine / Q000379:methods; D013537:Sutures; D013718:Tensile Strength
D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins; D005337:Fibrin