Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death.
Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.
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Florey
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Kim
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. overhom1@mskcc.org.
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Overholtzer
D000818:Animals; D017209:Apoptosis; D016923:Cell Death / Q000502:physiology*; D057691:Entosis / Q000502:physiology*; D006801:Humans