Prognostic nutritional index before adjuvant chemotherapy predicts chemotherapy compliance and survival among patients with non-small-cell lung cancer.
BACKGROUND
Adjuvant chemotherapy after the complete resection of non-small-cell lung cancer (NSCLC) is now the standard of care. To improve survival, it is important to identify risk factors for the continuation of adjuvant chemotherapy. In this study, we analyzed chemotherapy compliance and magnitude of the prognostic impact of the prognostic nutritional index (PNI) before adjuvant chemotherapy.


METHODS
We conducted a retrospective review of data from 106 patients who had received adjuvant chemotherapy. The adjuvant chemotherapy consisted of an oral tegafur agent (OT) or platinum-based chemotherapy (PB). The correlations between the PNI values and recurrence-free survival (RFS) were then evaluated.


RESULTS
In the PB group, the percentage of patients who completed the four planned cycles of chemotherapy was not correlated with the PNI. In the OT group, however, a significant difference was observed in the percentage of patients who completed the planned chemotherapy according to the PNI before adjuvant chemotherapy. The RFS of patients with a PNI <50 before adjuvant chemotherapy was significantly poorer than that of the patients with a PNI ≥50. A multivariate analysis showed that nodal metastasis and PNI before chemotherapy were independent predictors of the RFS. However, PNI before surgery was not a predictor of the RFS. In the subgroup analysis, PNI before chemotherapy was independent predictor of the RFS in the OT group (P=0.019), but not in the PB group (P=0.095).


CONCLUSIONS
The PNI before adjuvant chemotherapy influenced the treatment compliance with the planned chemotherapy in the OT group, but not the PB group. In addition, a low PNI before adjuvant chemotherapy was associated with a poor RFS in a multivariate analysis, especially in the OT group.
Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan.
Katsuhiko
K
Shimizu
Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan.
Riki
R
Okita
Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan.
Shinsuke
S
Saisho
Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan.
Takuro
T
Yukawa
Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan.
Ai
A
Maeda
Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan.
Yuji
Y
Nojima
Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan.
Masao
M
Nakata
adjuvant chemotherapy; non-small-cell lung cancer; prognostic nutritional index; treatment compliance