Laboratory-Acquired Infection with Salmonella enterica Serovar Typhimurium Exposed by Whole-Genome Sequencing.
Despite advances in laboratory design, professional training, and workplace biosafety guidelines, laboratory-acquired infections continue to occur. Effective tools are required to investigate cases and prevent future illness. Here, we demonstrate the value of whole-genome sequencing as a tool for the identification and source attribution of laboratory-acquired salmonellosis.
Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada University of Regina, Department of Biology, Regina, Saskatchewan, Canada dc.alexander1@gmail.com.
David C
DC
Alexander
University of Regina, Department of Biology, Regina, Saskatchewan, Canada.
Stephen F
SF
Fitzgerald
Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada Public Health Agency of Canada, Laboratory Surveillance Integration and Coordination Section, Winnipeg, Manitoba, Canada.
Rachel
R
DePaulo
Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada.
Rosanne
R
Kitzul
Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada.
Dawn
D
Daku
Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada University of Regina, Department of Biology, Regina, Saskatchewan, Canada.
Paul N
PN
Levett
University of Regina, Department of Biology, Regina, Saskatchewan, Canada.
Andrew D S
AD
Cameron
D000328:Adult; D000368:Aged; D002675:Child, Preschool; D005260:Female; D016680:Genome, Bacterial; D005838:Genotype; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D020641:Polymorphism, Single Nucleotide; D012480:Salmonella Infections / Q000175:diagnosis* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA