Adverse food-drug interactions.
Food supplements and herbal products are increasingly popular amongst consumers. This leads to increased risks of interactions between prescribed drugs and these products containing bioactive ingredients. From 1991 up to 2014, 55 cases of suspected adverse drug reactions due to concomitant intake of health-enhancing products and drugs were reported to Lareb, the Netherlands Pharmacovigilance Centre. An overview of these suspected interactions is presented and their potential mechanisms of action are described. Mainly during the metabolism of xenobiotics and due to the pharmacodynamics effects interactions seem to occur, which may result in adverse drug reactions. Where legislation is seen to distinct food and medicine, legislation concerning these different bioactive products is less clear-cut. This can only be resolved by increasing the molecular knowledge on bioactive substances and their potential interactions. Thereby potential interactions can be better understood and prevented on an individual level. By considering the dietary pattern and use of bioactive substances with prescribed medication, both health professionals and consumers will be increasingly aware of interactions and these interactive adverse effects can be prevented.
Department of Pharmacology and Toxicology, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. Electronic address: a.deboer@maastrichtuniversity.nl.
Alie
A
de Boer
Netherlands Pharmacovigilance Centre Lareb, Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 's-Hertogenbosch, The Netherlands.
Florence
F
van Hunsel
Department of Pharmacology and Toxicology, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Aalt
A
Bast
D016907:Adverse Drug Reaction Reporting Systems / Q000331:legislation & jurisprudence; D001711:Biotransformation; D003257:Consumer Product Safety / Q000331:legislation & jurisprudence*; D019587:Dietary Supplements / Q000009:adverse effects*; D018565:Food-Drug Interactions; D006291:Health Policy / Q000331:legislation & jurisprudence*; D041743:Herb-Drug Interactions; D006801:Humans; D060735:Pharmacovigilance; D028321:Plant Preparations / Q000009:adverse effects*; D011050:Policy Making; D018570:Risk Assessment; D012307:Risk Factors
D028321:Plant Preparations
Adverse interactions; Bioactives; European legislation; Food law; Food supplements; Health enhancing products; Medicinal products; Wellness