Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study.
This study was conducted to evaluate effects of rhBMP-2 applied at different concentrations to sandblasted and acid etched (SLA) implants on osseointegration and bone regeneration in a bone defect of beagle dogs as pilot study using split-mouth design. Methods. For experimental groups, SLA implants were coated with different concentrations of rhBMP-2 (0.1, 0.5, and 1 mg/mL). After assessment of surface characteristics and rhBMP-2 releasing profile, the experimental groups and untreated control groups (n = 6 in each group, two animals in each group) were placed in split-mouth designed animal models with buccal open defect. At 8 weeks after implant placement, implant stability quotients (ISQ) values were recorded and vertical bone height (VBH, mm), bone-to-implant contact ratio (BIC, %), and bone volume (BV, %) in the upper 3 mm defect areas were measured. Results. The ISQ values were highest in the 1.0 group. Mean values of VBH (mm), BIC (%), and BV (%) were greater in the 0.5 mg/mL and 1.0 mg/mL groups than those in 0.1 and control groups in buccal defect areas. Conclusion. In the open defect area surrounding the SLA implant, coating with 0.5 and 1.0 mg/mL concentrations of rhBMP-2 was more effective, compared with untreated group, in promoting bone regeneration and osseointegration.
Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705, Republic of Korea.
Nam-Ho
NH
Kim
Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Republic of Korea.
So-Hyoun
SH
Lee
Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705, Republic of Korea.
Jae-Jun
JJ
Ryu
Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Republic of Korea.
Kyung-Hee
KH
Choi
Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Republic of Korea.
Jung-Bo
JB
Huh
D000134:Acid Etching, Dental; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage*; D001861:Bone Regeneration / Q000187:drug effects*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D015921:Dental Implants; D004285:Dogs; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000187:drug effects*; D010865:Pilot Projects; D011994:Recombinant Proteins / Q000008:administration & dosage; D014025:Titanium
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D011994:Recombinant Proteins; D014025:Titanium