Celiac Disease: Diagnosis.
Historically the diagnosis of celiac disease has relied upon clinical, serological, and histological evidence. In recent years the use of sensitive serological methods has meant an increase in the diagnosis of celiac disease. The heterogeneous nature of the disorder presents a challenge in the study and diagnosis of the disease with patients varying from subclinical or latent disease to patients with overt symptoms. Furthermore the related gluten-sensitive disease dermatitis herpetiformis, while distinct in some respects, shares clinical and serological features with celiac disease. Here we summarize current best practice for the diagnosis of celiac disease and briefly discuss newer approaches. The advent of next-generation assays for diagnosis and newer clinical protocols may result in more sensitive screening and ultimately the possible replacement of the intestinal biopsy as the gold standard for celiac disease diagnosis.
School of Biological Sciences, Dublin Institute of Technology, Kevin St., Dublin, 8, Ireland. greg.byrne@dit.ie.
Greg
G
Byrne
Immunology Department, Trinity College, Dublin, Ireland.|Immunology Department, St. James's Hospital, Dublin, Ireland.
Conleth F
CF
Feighery
D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans
D015415:Biomarkers; D006680:HLA Antigens
Autoantibodies; Celiac; Diagnosis; Symptoms