Factoring the brain signatures of anesthesia concentration and level of arousal across individuals.
Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.
Universidad Torcuato di Tella, Almirante Juan Saenz Valiente 1010, Buenos Aires C1428BIJ, Argentina ; Cognitive Neuroimaging Unit, CEA DSV/I2BM, INSERM, Université Paris-Sud, Université Paris-Saclay, NeuroSpin center, 91191 Gif/Yvette, France.
Pablo
P
Barttfeld
Cognition and Brain Sciences Unit, Medical Research Council, Cambridge CB2 7EF, UK ; Department of Psychology, University of Cambridge, Cambridge, UK.
Tristan A
TA
Bekinschtein
Universidad Torcuato di Tella, Almirante Juan Saenz Valiente 1010, Buenos Aires C1428BIJ, Argentina ; Instituto de Cálculo, FCEN, Universidad de Buenos Aires and CONICET, Argentina.
Alejo
A
Salles
Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Emmanuel A
EA
Stamatakis
Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Ram
R
Adapa
Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
David K
DK
Menon
Universidad Torcuato di Tella, Almirante Juan Saenz Valiente 1010, Buenos Aires C1428BIJ, Argentina.
Mariano
M
Sigman
D000328:Adult; D001143:Arousal / Q000187:drug effects*; D001921:Brain / Q000098:blood supply / Q000187:drug effects*; D001931:Brain Mapping; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood / Q000494:pharmacology*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D015742:Propofol / Q000097:blood / Q000494:pharmacology*; D012044:Regression Analysis; D055815:Young Adult
D006993:Hypnotics and Sedatives; D010100:Oxygen; D015742:Propofol