Quantitative study of optical and mechanical bone status using multispectral photoacoustics.
Osteoporosis is a major public health problem worldwide. Here, we present a quantitative multispectral photoacoustic method for the evaluation of bone pathologies which has significant advantages over pure ultrasonic or pure optical methods as it provides both molecular information and bone mechanical status. This is enabled via a simultaneous measurement of the bone's optical properties as well as the speed of sound and ultrasonic attenuation in the bone. To test the method's quantitative predictions, a combined ultrasonic and photoacoustic system was developed. Excitation was performed optically via a portable triple laser-diode system and acoustically via a single element transducer. Additional dual transducers were used for detecting the acoustic waves that were generated by the two modalities. Both temporal and spectral parameters were compared between different excitation wavelengths and measurement modalities. Short photoacoustic excitation wavelengths allowed sensing of the cortical layer while longer wavelengths produced results which were compatible with the quantitative ultrasound measurements.
The Laboratory for Optics and Lasers in Medicine, Dept. of BME, Tel-Aviv University, Israel, Haim Levanon St., Tel Aviv, P.O. Box 39040, Tel Aviv, 6997801, Israel. idanstei@gmail.com.|The Laboratory for Optics and Photonics, School of EE, Tel-Aviv University, Israel, Haim Levanon St., Tel Aviv, P.O. Box 39040, Tel Aviv, 6997801, Israel. idanstei@gmail.com.
Idan
I
Steinberg
The Biomedical Optical Microscopy, Nanoscopy and Interferometry Research Group, Dept. of BME, Tel-Aviv University, Israel, Haim Levanon St., Tel Aviv, P.O. Box 39040, Tel Aviv, 6997801, Israel.
Nir
N
Turko
The Laboratory for Optics and Photonics, School of EE, Tel-Aviv University, Israel, Haim Levanon St., Tel Aviv, P.O. Box 39040, Tel Aviv, 6997801, Israel.
Omri
O
Levi
The Laboratory for Optics and Lasers in Medicine, Dept. of BME, Tel-Aviv University, Israel, Haim Levanon St., Tel Aviv, P.O. Box 39040, Tel Aviv, 6997801, Israel.|Dept. of ECE, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Israel
I
Gannot
The Laboratory for Optics and Photonics, School of EE, Tel-Aviv University, Israel, Haim Levanon St., Tel Aviv, P.O. Box 39040, Tel Aviv, 6997801, Israel.
Avishay
A
Eyal
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002645:Chickens; D061088:Photoacoustic Techniques; D013057:Spectrum Analysis; D014159:Transducers; D014463:Ultrasonography
broadband ultrasonic attenuation; osteoporosis; photoacoustics; quantitative ultrasound; speed of sound