BALB/c and SWR inbred mice differ in post-oral fructose appetition as revealed by sugar versus non-nutritive sweetener tests.
Recent studies indicate that C57BL/6J (B6) and FVB inbred mouse strains differ in post-oral fructose conditioning. This was demonstrated by their differential flavor conditioning response to intragastric fructose and their preference for fructose versus a non-nutritive sweetener. The present study extended this analysis to SWR and BALB/c inbred strains which are of interest because they both show robust flavor conditioning responses to fructose. In the first experiment, ad-libitum fed mice were given a series of 2-day, two-bottle preference tests between 8% fructose and a more preferred, but non-nutritive 0.1% sucralose +0.1% saccharin (S+S) solution (tests 1 & 4), and fructose or S+S versus water (tests 2 and 3). In test 1, SWR mice preferred S+S to fructose, and in tests 2 and 3, they preferred both sweeteners to water. In test 4, SWR mice switched their preference and consumed more fructose than S+S. In contrast, ad-libitum fed BALB/c mice strongly preferred S+S to fructose in both tests 1 and 4, although they preferred both sweeteners to water in tests 2 and 3. Food-restricted BALB/c mice also preferred the non-nutritive S+S to fructose in tests 1 and 4. The experience-induced fructose preference reversal observed in SWR, but not BALB/c mice indicates that fructose has a post-oral reinforcing effect in SWR mice as in FVB mice. Because B6 and FVB mice prefer glucose to fructose based on the post-oral actions of the two sugars, the second experiment compared the preferences of SWR and BALB/c mice for 8% glucose and fructose solutions. Ad-libitum fed and food-restricted SWR mice strongly preferred glucose to fructose. In contrast, ad-libitum fed BALB/c mice were indifferent to the sugars, perhaps because of their overall low intakes. Food-restricted BALB/c mice, however, strongly preferred glucose. These findings indicate that SWR and BALB/c mice differ in their preference response to the post-oral actions of fructose.
Behavioral and Cognitive Neuroscience Cluster of the Psychology Doctoral Program, The Graduate Center, City University of New York, New York, NY, USA.
Tamar T
TT
Kraft
Department of Psychology, Queens College, City University of New York, New York, NY, USA.
Donald
D
Huang
Department of Psychology, Queens College, City University of New York, New York, NY, USA.
Melanie
M
Lolier
Department of Psychology, Queens College, City University of New York, New York, NY, USA.
Deena
D
Warshaw
Department of Psychology, Queens College, City University of New York, New York, NY, USA.
Sam
S
LaMagna
Department of Psychology, Queens College, City University of New York, New York, NY, USA.
Elona
E
Natanova
Behavioral and Cognitive Neuroscience Cluster of the Psychology Doctoral Program, The Graduate Center, City University of New York, New York, NY, USA; Department of Psychology, Brooklyn College, City University of New York, New York, NY, USA.
Anthony
A
Sclafani
Behavioral and Cognitive Neuroscience Cluster of the Psychology Doctoral Program, The Graduate Center, City University of New York, New York, NY, USA; Department of Psychology, Queens College, City University of New York, New York, NY, USA. Electronic address: richard.bodnar@qc.cuny.edu.
Richard J
RJ
Bodnar
D000818:Animals; D004338:Drug Combinations; D005508:Food Deprivation; D005518:Food Preferences / Q000187:drug effects*; D005632:Fructose / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D012054:Reinforcement, Psychology; D012439:Saccharin / Q000008:administration & dosage / Q000494:pharmacology*; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D004338:Drug Combinations; D005632:Fructose; D013395:Sucrose; C026285:trichlorosucrose; D012439:Saccharin; D005947:Glucose
Fructose; Glucose; Learning; Saccharin; Sucralose