Dyslipidaemia: Lysosomal acid lipase deficiency-a cautious leap forward.
Lysosomal acid lipase deficiency can lead to liver failure and early death. A recently published placebo-controlled trial shows that enzyme-replacement therapy improves plasma levels of lipids and aminotransferases, and reduces liver fat content. However, the effect on clinical end points and an appropriate indication for treatment remain to be established.
Department of Internal Medicine, Division of Endocrinology and Metabolism, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam 16:35, Netherlands.
Carla E M
CE
Hollak
Department of Internal Medicine, Division of Vascular Medicine, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam 16:35, Netherlands.
G Kees
GK
Hovingh
D005260:Female; D006801:Humans; D008297:Male; D002787:Sterol Esterase / Q000627:therapeutic use*; D015223:Wolman Disease / Q000188:drug therapy*
D002787:Sterol Esterase