Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc.
We investigate the deformation characteristics of red blood cells (RBCs) on a rotating compact disc platform. Our study brings out the interplay between haemoglobin content and RBC deformability in a centrifugally actuated microfluidic environment. We reveal that RBC deformations follow the similar trend of principal stress distributed throughout the radial direction, rendering an insight into the mechano-physical processes involved. This study can be used as a diagnostic marker to determine haematological disorders in diseased blood samples tested on compact disc based microfluidic platforms.
Advanced Technology Development Centre, Indian Institute of Technology Kharagpur, Kharagpur-721302, India. suman@mech.iitkgp.ernet.in.
Shantimoy
S
Kar
Uddipta
U
Ghosh
Tapas Kumar
TK
Maiti
Suman
S
Chakraborty
D016250:Compact Disks; D004867:Equipment Design; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000737:chemistry / Q000166:cytology*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*
D006454:Hemoglobins