Not fibrin(ogen), but fibrinogen or fibrin.
In this issue of Blood, Prasad et al describe a mouse model with a mutation in the Aα chain of fibrinogen such that no fibrin polymer is formed in vivo, allowing for the first time the differentiation of the role of fibrinogen vs fibrin oligomer or polymer in antimicrobial host defense and in hemostasis/thrombosis.
UNIVERSITY OF PENNSYLVANIA.
Rustem I
http://orcid.org/0000-0003-0643-1496
RI
Litvinov
UNIVERSITY OF PENNSYLVANIA.
John W
http://orcid.org/0000-0002-9628-257X
JW
Weisel
D000818:Animals; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000502:physiology*; D054884:Host-Pathogen Interactions; D009154:Mutation / Q000235:genetics*; D010538:Peritonitis / Q000209:etiology*; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*
D005337:Fibrin; D005340:Fibrinogen