Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System.
The blood-brain barrier is a serious impediment to the delivery of pharmaceutical treatments for brain diseases, including cancer, neurodegenerative and neuropsychatric diseases. Focused ultrasound, when combined with microbubbles, has emerged as an effective method to transiently and locally open the blood-brain barrier to promote drug delivery to the brain. Focused ultrasound has been used to successfully deliver a wide variety of therapeutic agents to pre-clinical disease models. The requirement for clinical translation of focused ultrasound technology is considered.
Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Alison
A
Burgess
Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada. khynynen@sri.utoronto.ca.|Medical Biophysics, University of Toronto, Toronto, ON, Canada. khynynen@sri.utoronto.ca.
Kullervo
K
Hynynen
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D016503:Drug Delivery Systems; D006801:Humans; D045423:Microbubbles; D014465:Ultrasonics
Alzheimer’s disease; Blood-brain barrier; Drug delivery; Focused ultrasound; Glioblastoma