Macro- and microglial responses in the fellow eyes contralateral to glaucomatous eyes.
Most studies employing experimental models of unilateral glaucoma have used the normotensive contralateral eye as the normal control. However, some studies have recently reported the activation of the retinal macroglia and microglia in the uninjured eye, suggesting that the eye contralateral to experimental glaucoma should not be used as a control. This review analyzes the studies describing the contralateral findings and discusses some of the routes through which the signals can reach the contralateral eye to initiate the glial reactivation.
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Facultad de Óptica y Optometría, Universidad Complutense de Madrid, Spain. Electronic address: airamirez@med.ucm.es.
Ana I
AI
Ramírez
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Facultad de Óptica y Optometría, Universidad Complutense de Madrid, Spain.
Juan J
JJ
Salazar
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Facultad de Óptica y Optometría, Universidad Complutense de Madrid, Spain.
Rosa
R
de Hoz
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Departamento de Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Blanca
B
Rojas
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, Spain.
Beatriz I
BI
Gallego
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, Spain.
Elena
E
Salobrar-García
Laboratorio de Oftalmología Experimental, Departamento de Oftalmología, Facultad de Medicina, Universidad de Murcia, Spain.
Francisco J
FJ
Valiente-Soriano
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Departamento de Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Alberto
A
Triviño
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Departamento de Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
José M
JM
Ramirez
D000818:Animals; D007839:Functional Laterality / Q000502:physiology*; D005901:Glaucoma / Q000473:pathology*; D006801:Humans; D009457:Neuroglia / Q000378:metabolism / Q000473:pathology*; D012160:Retina / Q000473:pathology*
ACAID; Astrocytes; Blood-retinal barrier; Contralateral eye; Experimental glaucoma; Immune system; Inflammation; Macroglia; Microglia; Müller cells; Retina