[A Case of Extranodal Nasal Type, NK／T Cell Lymphoma in the Ileum with Perforated Peritonitis during Chemotherapy].
A 65-year-old woman complaining of melena and a high fever was admitted to our hospital. Colonoscopy revealed a large tumor with a wide ulcer in the terminal ileum, and nasal type, extranodal NK/T cell lymphoma was suspected via biopsy. Owing to rapid progression of hepatocellular damage with hepatomegaly and splenomegaly, chemotherapy with CHOP was initiated immediately. Two days later, the patient developed panperitonitis, and emergency laparotomy was performed. The tumor in the terminal ileum widely adhered to the bladder, where a deep perforated ulcer was found, for which palliative ileocecal resection was performed. Enlargement of the residual tumor caused an abdominal abscess, intestinal obstruction, and hepatic failure, and the patient died 75 days after surgery. In summary, we initiated chemotherapy to control the deteriorating systemic condition of the patient. However, nasal type, extranodal NK/T cell lymphoma is a rapidly progressing lymphoma occasionally accompanied by perforation of the tumor. Surgery preceding chemotherapy should be considered an alternative treatment.
Dept. of Surgery, Aomori Prefectural Central Hospital.
Tomohisa
T
Tokura
Shinsuke
S
Nishikawa
Takafumi
T
Yachi
Minoru
M
Umehara
Yutaka
Y
Umehara
Akihiko
A
Murata
Kenichi
K
Takahashi
Takayuki
T
Morita
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D054391:Lymphoma, Extranodal NK-T-Cell / Q000188:drug therapy* / Q000601:surgery; D064847:Multimodal Imaging; D010538:Peritonitis / Q000209:etiology*; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000009:adverse effects
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone