Efficacy of Compound Kushen Injection in Relieving Cancer-Related Pain: A Systematic Review and Meta-Analysis.
Despite widespread popular use of complementary and alternative medicine (CAM) therapies, a rigorous evidence based on the efficacy of compound kushen injection (CKI) for cancer-related pain is lacking. In this study, we evaluated the efficacy and safety of compound kushen injection and provided information for current or future research and clinical application. Sixteen trials were identified with a total of 1564 patients. The total pain relief rate of CKI plus chemotherapy is better than chemotherapy except for colorectal cancer. The treatment groups achieved a reduction in the incidences of leukopenia and gastrointestinal, hepatic, and renal functional lesion. However, there is paucity of multi-institutional RCTs evaluating compound kushen injection for cancer pain with adequate power, duration, and sham control. The quantity and quality of RCTs are lower so that we still have to boost the research level through scientific design and normative report.
China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China.
Yu-Ming
YM
Guo
China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China.
Yi-Xue
YX
Huang
China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China.
Hong-Hui
HH
Shen
China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China.
Xiu-Xiu
XX
Sang
China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China.
Xiao
X
Ma
China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China.
Yan-Ling
YL
Zhao
China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China ; Integrative Medicine Center, 302 Military Hospital, Beijing 100039, China.
Xiao-He
XH
Xiao