Global gene expression profiling data analysis reveals key gene families and biological processes inhibited by Mithramycin in sarcoma cell lines.
The role of Mithramycin as an anticancer drug has been well studied. Sarcoma is a type of cancer arising from cells of mesenchymal origin. Though incidence of sarcoma is not of significant percentage, it becomes vital to understand the role of Mithramycin in controlling tumor progression of sarcoma. In this article, we have analyzed the global gene expression profile changes induced by Mithramycin in two different sarcoma lines from whole genome gene expression profiling microarray data. We have found that the primary mode of action of Mithramycin is by global repression of key cellular processes and gene families like phosphoproteins, kinases, alternative splicing, regulation of transcription, DNA binding, regulation of histone acetylation, negative regulation of gene expression, chromosome organization or chromatin assembly and cytoskeleton.
Genome Informatics Research Group, Bionivid Technology Pvt Ltd., Bangalore 560043, India.
Kirti K
KK
Kulkarni
Genome Informatics Research Group, Bionivid Technology Pvt Ltd., Bangalore 560043, India.
Kiran Gopinath
KG
Bankar
Genome Informatics Research Group, Bionivid Technology Pvt Ltd., Bangalore 560043, India.
Rohit Nandan
RN
Shukla
Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata 700064, India.
Chandrima
C
Das
Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata 700064, India.
Amrita
A
Banerjee
Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata 700064, India.
Dipak
D
Dasgupta
Genome Informatics Research Group, Bionivid Technology Pvt Ltd., Bangalore 560043, India.
Madavan
M
Vasudevan
Global gene expression; Microarray; Mithramycin; Sarcoma