Hepatoprotective iridoid glucosides from Callicarpa nudiflora.
Two new iridoid glucosides, callicoside A (1) and callicoside B (2), were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated by means of spectroscopic methods and chemical evidences. In an in vitro bioassay, compound 1 showed pronounced hepatoprotective activity against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
a Jiangxi Provincial Institute for Drug Control, Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality , Nanchang 330029 , China.
Yue-Hua
YH
Luo
a Jiangxi Provincial Institute for Drug Control, Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality , Nanchang 330029 , China.
Hui-Zheng
HZ
Fu
a Jiangxi Provincial Institute for Drug Control, Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality , Nanchang 330029 , China.
Bo
B
Huang
a Jiangxi Provincial Institute for Drug Control, Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality , Nanchang 330029 , China.
Wei-Kang
WK
Chen
b National Institutes for Food and Drug Control , Beijing 100050 , China.
Shuang-Cheng
SC
Ma
D000818:Animals; D032408:Callicarpa / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005688:Galactosamine / Q000494:pharmacology; D057888:Iridoid Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D011916:Rats, Inbred F344
D004365:Drugs, Chinese Herbal; D057888:Iridoid Glucosides; C000609938:callicoside A; C000609939:callicoside B; D005688:Galactosamine
Callicarpa nudiflora; Verbenacase; hepatoprotective activity; iridoid glucosides