Liver resection for metastatic colorectal leiomyosarcoma: a single center experience.
BACKGROUND
Leiomyosarcoma arising in the colorectum is a rare malignancy of the smooth muscles accounting for less than 1% of gastrointestinal tumors. Surgery remains the most accepted modality for the treatment of this entity however management of liver metastases remains controversial.


RESULTS
From 1998 to 2009, five patients diagnosed with primary leiomyosarcoma of colorectal origin with metastatic liver disease, underwent liver resections at the American University of Beirut Medical Center. The median overall survival was 47 months (range, 7-135 months).


CONCLUSIONS
Leiomyosarcoma of colorectal origin with liver metastasis is a very rare entity. Long-term survival can be achieved after surgical resection and should be considered for all patients.
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Walid
W
Faraj
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Jessica
J
El-Kehdy
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Ghina El
GE
Nounou
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Samer
S
Deeba
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Hawraa
H
Fakih
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Mark
M
Jabbour
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Ali
A
Haydar
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Abdallah Abou
AA
El Naaj
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Ghassan K
GK
Abou-Alfa
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Eileen M
EM
O'Reilly
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Ali
A
Shamseddine
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Mohamad
M
Khalife
1 Liver Transplantation and Hepatopancreaticobiliary Surgery, Department of General Surgery, 2 Department of Surgery, 3 Division of Hematology and Oncology, Department of Internal Medicine, 4 Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon ; 5 Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Deborah
D
Mukherji
Leiomyosarcoma; colon; liver; metastasis; rectum