Identifying the role of cytochrome c in post-resuscitation pathophysiology.
Cytochrome c, an electron carrier that normally resides in the mitochondrial intermembrane space, may translocate to the cytosol under ischemic and hypoxic conditions and contribute to mitochondrial permeability transition pore opening. In addition, reperfusion of brain tissue following ischemia initiates a cell death cascade that includes cytochrome c-mediated induction of apoptosis. Further studies are needed to determine the contribution of cytochrome c in the regulation of cell death, as well as its value as an in vivo prognostic marker after cardiac arrest and resuscitation.
National and Kapodistrian University of Athens, Medical School, MSc "Cardiopulmonary Resuscitation", Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece. Electronic address: thanoschalkias@yahoo.gr.
Athanasios
A
Chalkias
V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russian Federation.
Artem
A
Kuzovlev
Department of Public Health, Clinical and Molecular Medicine, Forensic Science Unit, University of Cagliari, Cagliari, Italy.
Antonio
A
Noto
Department of Public Health, Clinical and Molecular Medicine, Forensic Science Unit, University of Cagliari, Cagliari, Italy.
Ernesto
E
d'Aloja
Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; European University of Cyprus, School of Medicine, Nicosia, Cyprus.
Theodoros
T
Xanthos
D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers; D003574:Cytochrome c Group / Q000502:physiology*; D006323:Heart Arrest / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology* / Q000628:therapy; D007511:Ischemia / Q000503:physiopathology* / Q000628:therapy; D033681:Mitochondrial Membrane Transport Proteins / Q000502:physiology; D000083162:Mitochondrial Permeability Transition Pore; D012151:Resuscitation
D015415:Biomarkers; D003574:Cytochrome c Group; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore