Involvement of Membrane Blebbing in Immunological Disorders and Cancer.
Cellular blebbing is a unique form of dynamic protrusion emanating from the plasma membrane which can be either apoptotic or nonapoptotic in nature. Blebs have been observed in a wide variety of cell types and in response to multiple mechanical and chemical stimuli. They have been linked to various physiological and pathological processes including tumor motility and invasion, as well as to various immunological disorders. They can form and retract extremely rapidly in seconds or minutes, or slowly over hours or days. This review focuses on recent evidence regarding the role of blebbing in cell locomotion with particular emphasis on its role in tumor metastasis, indicating the role of specific causative molecules. The phenomenon of blebbing has been observed in endocrine-resistant breast cancer cells in response to brief exposure to extracellular alkaline pH, which leads to enhanced invasive capacity. Genetic or pharmacological targeting of cellular blebs could serve as a potential therapeutic option to control tumor metastasis.
Departments of Pharmacology and Therapeutics, Kuwait University, Safat, Kuwait.
Maitham A
MA
Khajah
Yunus A
YA
Luqmani
D000818:Animals; D017209:Apoptosis; D001768:Blister; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology*; D002465:Cell Movement; D064550:Death-Associated Protein Kinases; D005260:Female; D006801:Humans; D007154:Immune System Diseases; D009362:Neoplasm Metastasis / Q000517:prevention & control; D011519:Proto-Oncogenes; D020742:rhoA GTP-Binding Protein; D019061:src-Family Kinases
D019061:src-Family Kinases; C579096:DAPK1 protein, human; D064550:Death-Associated Protein Kinases; D020742:rhoA GTP-Binding Protein