Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles.
Nanoparticles are widely used for targeted drug delivery applications. Surface modification with appropriate polymer and ligands is carried out to target the drug to the affected area. Toxicity analysis is carried out to evaluate the safety of the surface modified nanoparticles. In this study, paclitaxel attached, folic acid functionalized, polyethylene glycol modified hydroxyapatite and titanium dioxide nanoparticles were used for targeted drug delivery system. The toxicological behavior of the system was studied in vivo in rats and mice. Acute and subchronic studies were carried out. Biochemical, hematological, and histopathological analysis was also done. There were no significant alterations in the biochemical parameters at a low dosage. There was a small change in alkaline phosphatase (ALP) level at a high dosage. The results indicate a safe toxicological profile.
Department of Biotechnology, University of Madras, Chennai, Tamil Nadu, India.
Gopinath Devanand
GD
Venkatasubbu
Crystal Growth Centre, Anna University, Chennai, Tamil Nadu, India.
S
S
Ramasamy
Department of Pharmacology, Siddha Central Research Institute, Chennai, Tamil Nadu, India.
Pramod Reddy
PR
Gaddam
Crystal Growth Centre, Anna University, Chennai, Tamil Nadu, India.
J
J
Kumar
D000818:Animals; D001774:Blood Chemical Analysis; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D007150:Immunohistochemistry; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry; D051381:Rats; D014025:Titanium / Q000737:chemistry*
D011108:Polymers; C009495:titanium dioxide; D017886:Durapatite; D014025:Titanium; D017239:Paclitaxel
acute and subchronic toxicology; biochemical analysis; hematological analysis; histopathology