Infective endocarditis associated with acute leukemia: Report of two cases.
There have been few reports regarding infective endocarditis (IE) in patients with leukemia. In the first case, a 15-year-old girl with Down syndrome was diagnosed with acute lymphoblastic leukemia. On admission, methicillin-sensitive Staphylococcus aureus (MSSA) was detected on blood culture. Echocardiography was performed because MSSA was detected repeatedly even after treatment. Vegetation in all of the atria and ventricles met the Duke criteria defining IE. She died of multiple organ failure 21 days after diagnosis. In the second case, an 11-year-old boy with acute myeloid leukemia underwent peripheral blood stem cell transplantation (PBSCT). He had fever 68 days after PBSCT, and methicillin-resistant S. aureus (MRSA) was detected on blood culture. Echocardiography showed vegetation in the right atrium and ventricle. Daptomycin was administered for 7 weeks, and recurrence was not observed. IE should be considered when S. aureus bacteremia is documented even in patients with leukemia.
Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan.
Dai
D
Keino
Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan.
Yoshimitsu
Y
Tsuzuki
Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan.
Takashi
T
Mori
Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan.
Shiori
S
Kakuage
Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan.
Marie
M
Nakano
Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan.
Kentaro
K
Asoh
Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan.
Tetsuya
T
Mori
Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan.
Akitoshi
A
Kinoshita
Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan.
Hitoshi
H
Yamamoto
D000293:Adolescent; D002648:Child; D003937:Diagnosis, Differential; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000209:etiology*
Staphylococcus aureus; acute leukemia; daptomycin; infective endocarditis