Acute Liver Failure in a Pediatric Patient with Congenital Dysery-Thropoietic Anemia Type I Treated with Deferasirox.
Congenital dyserythropoietic anemias (CDA) represent a heterogeneous group of disorders characterized by morphological abnormalities of erythroid precursor cells and various degrees of hemolysis. Iron overload is a result of continuous hemolysis and recurrent transfusions. It is treated with iron chelators, including deferasirox. We present here a case of acute liver failure in a 12 years old girl with CDA type I treated with deferasirox and discuss the approach to treatment.
Pediatric Gastroenterology and Nutrition Unit.
Galina
G
Ling
Pediatric Gastroenterology and Nutrition Unit.
Vered
V
Pinsk
Pediatrics Department B, Saban Pediatric Medical Center for Israel, Soroka University Medical Center , Beer Sheva, Israel.
Inbal
I
Golan-Tripto
Pediatrics Department B, Saban Pediatric Medical Center for Israel, Soroka University Medical Center , Beer Sheva, Israel.
Eduard
E
Ling
Congenital dyserythropoietic anemia; N-acetylcysteine; acute liver failure; deferasirox