Erythroferrone: the missing link in β-thalassemia?
In this issue of Blood, Kautz et al show that the ablation of the erythroid-derived factor erythroferrone (ERFE), which has been shown to be highly expressed in β-thalassemic mice, restores hepcidin levels and corrects iron overload. However, correction of hepcidin levels in those mice does not improve anemia of β-thalassemia.
IMAGINE INSTITUTE.
Ivan C
http://orcid.org/0000-0002-8418-2803
IC
Moura
IMAGINE INSTITUTE.
Olivier
O
Hermine
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D064451:Hepcidins / Q000378:metabolism*; D019190:Iron Overload / Q000209:etiology*; D008297:Male; D009124:Muscle Proteins / Q000502:physiology*; D017086:beta-Thalassemia / Q000150:complications* / Q000473:pathology*
D016207:Cytokines; D064451:Hepcidins; D009124:Muscle Proteins