Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C.
Sofosbuvir and simeprevir are used for the treatment of chronic hepatitis C (HCV) genotype 1. Both drugs have been well-tolerated, with diarrhea noted in 6% cases with sofosbuvir, 16% with sofosbuvir plus simeprevir, and 0% with simeprevir. No prior reports exist of colitis secondary to either drug or their combination. We report a patient with no prior history of inflammatory bowel disease who developed significant bloody diarrhea within 2 weeks of sofosbuvir/simeprevir initiation. Colonoscopy and biopsy confirmed pancolitis, which responded to mesalamine and completion of sofosbuvir/simeprevir.
Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT.
Souvik
S
Sarkar
Department of Pathology, Yale University School of Medicine, New Haven, CT.
Kisha A
KA
Mitchell
Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT.
Joseph K
JK
Lim
IBD Center, Mount Sinai Beth Israel, New York, NY.
Ioannis
I
Oikonomou
Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT.
Simona
S
Jakab