Correlation between myeloid-derived suppressor cells and S100A8/A9 in tumor and autoimmune diseases.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that constitute an important component of immune regulatory system. Two calcium-binding proteins S100A8 and S100A9 act as important mediators in acute and chronic inflammation. In recent years, many researchers have found that MDSCs and S100A8/A9 operated with one another through a positive feedback loop to promote tumor development and metastasis. However, the correlation between MDSCs and S100A8/A9 in autoimmune diseases (AIDs) remains unknown. In this review, we discussed the co-operation of MDSCs and S100A8/A9 in tumor environment, and also, the role of these two components in AIDs.
Department of Endocrinology and Rheumatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, China.
Ruoting
R
Zheng
Department of Endocrinology and Rheumatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, China.
Shiyi
S
Chen
Department of Endocrinology and Rheumatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, China. Electronic address: chen-shenren@163.com.
Shenren
S
Chen
D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism*; D040501:Calgranulin A / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism*; D022423:Myeloid Cells / Q000276:immunology* / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism*
D040501:Calgranulin A
Autoimmune diseases (AIDs); Myeloid-derived suppressor cells (MDSCs); S100A8/A9; Tumor