Managing patients with side effects and adverse events to immunoglobulin therapy.
Immunoglobulin therapy has not only served as a lifesaving approach for the prevention and treatment of infections in primary and secondary immunodeficiency diseases, but has also been used as an immunomodulatory agent for autoimmune and inflammatory disorders and to provide passive immunity for some infectious diseases. Most of the adverse effects associated with immunoglobulin therapy are mild, transient and self-limiting. However, serious side effects also occur. Therefore, to minimize the adverse events of immunoglobulin therapy, specialist review of patient clinical status and immunoglobulin products, in addition to selection of appropriate treatment strategy for the management of patients with associated side effects and adverse events, are crucial.
a Imam Hassan Mojtaba Hospital , Alborz University of Medical Sciences , Karaj , Iran.|b Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
Gholamreza
G
Azizi
b Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.|c Division of Clinical Immunology, Department of Laboratory Medicine , Karolinska Institute at Karolinska University Hospital Huddinge , Stockholm , Sweden.
Hassan
H
Abolhassani
b Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
Mohammad Hossein
MH
Asgardoon
b Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.|d Faculty of Medicine , Guilan University of Medical Sciences , Rasht , Iran.
Shiva
S
Shaghaghi
e School of Advanced Technologies in Medicine, Department of Medical Biotechnology, Tehran University of Medical Sciences , Tehran , Iran.
Babak
B
Negahdari
f Department of Biomedical Engineering, Faculty of New Sciences and Technologies, University of Tehran , Tehran , Iran.
Javad
J
Mohammadi
b Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
Nima
N
Rezaei
b Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
Asghar
A
Aghamohammadi
D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D006801:Humans; D007116:Immunization, Passive / Q000009:adverse effects* / Q000379:methods; D007136:Immunoglobulins / Q000009:adverse effects* / Q000627:therapeutic use; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy; D007155:Immunologic Factors / Q000009:adverse effects* / Q000627:therapeutic use; D007249:Inflammation / Q000276:immunology / Q000628:therapy
D007136:Immunoglobulins; D007155:Immunologic Factors
Immunoglobulin therapy; adverse events; high dose immunomodulation; routes of administration; side effects