The challenge of antibiotic resistance in haematology patients.
Bacterial infections were once a major obstacle to the treatment of acute leukaemia. Improvement in management strategies, including the use of broad-spectrum antibacterial drugs targeting Gram-negative bacteria, has reduced the mortality in neutropenic patients developing blood stream infections and other severe infections. In many countries these achievements are threatened by development of multi-resistant bacteria, such as Klebsiella pneumoniae, Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. This review addresses the epidemiology, clinical importance and possible management of these multi-resistant organisms.
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.|Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Ola
O
Blennow
Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.|Department of Haematology and Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden.
Per
P
Ljungman
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial; D005544:Forecasting; D014943:Global Health; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology*; D006402:Hematologic Diseases / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D058990:Molecular Targeted Therapy / Q000379:methods; D055815:Young Adult
D000900:Anti-Bacterial Agents
Leukaemia; antimicrobial therapy; bacterial infections; neutropenia; stem cell transplantation