Qualitative grading of aortic regurgitation: a pilot study  comparing CMR 4D flow and echocardiography.
Over the past 10 years there has been intense research in the development of volumetric visualization of intracardiac flow by cardiac magnetic resonance (CMR).This volumetric time resolved technique called CMR 4D flow imaging has several advantages over standard CMR. It offers anatomical, functional and flow information in a single free-breathing, ten-minute acquisition. However, the data obtained is large and its processing requires dedicated software. We evaluated a cloud-based application package that combines volumetric data correction and visualization of CMR 4D flow data, and assessed its accuracy for the detection and grading of aortic valve regurgitation using transthoracic echocardiography as reference. Between June 2014 and January 2015, patients planned for clinical CMR were consecutively approached to undergo the supplementary CMR 4D flow acquisition. Fifty four patients(median age 39 years, 32 males) were included. Detection and grading of the aortic valve regurgitation using CMR4D flow imaging were evaluated against transthoracic echocardiography. The agreement between 4D flow CMR and transthoracic echocardiography for grading of aortic valve regurgitation was good (j = 0.73). To identify relevant,more than mild aortic valve regurgitation, CMR 4D flow imaging had a sensitivity of 100 % and specificity of 98 %. Aortic regurgitation can be well visualized, in a similar manner as transthoracic echocardiography, when using CMR 4D flow imaging.
Department of Radiology, Erasmus MC, 's-Gravendijkwal 230, Room: Ca-207a, 3015 CE, Rotterdam, The Netherlands. ralucachelu@hotmail.com.|Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands. ralucachelu@hotmail.com.
Raluca G
RG
Chelu
Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
Annemien E
AE
van den Bosch
Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
Matthijs
M
van Kranenburg
Department of Radiology, University of California, San Diego, San Diego, CA, USA.
Albert
A
Hsiao
Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
Allard T
AT
van den Hoven
Department of Radiology, Erasmus MC, 's-Gravendijkwal 230, Room: Ca-207a, 3015 CE, Rotterdam, The Netherlands.
Mohamed
M
Ouhlous
Department of Radiology, Erasmus MC, 's-Gravendijkwal 230, Room: Ca-207a, 3015 CE, Rotterdam, The Netherlands.|Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
Ricardo P J
RPJ
Budde
Department of Radiology, Erasmus MC, 's-Gravendijkwal 230, Room: Ca-207a, 3015 CE, Rotterdam, The Netherlands.
Kirsten M
KM
Beniest
Department of Radiology, Erasmus MC, 's-Gravendijkwal 230, Room: Ca-207a, 3015 CE, Rotterdam, The Netherlands.|Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
Laurens E
LE
Swart
Department of Radiology, Erasmus MC, 's-Gravendijkwal 230, Room: Ca-207a, 3015 CE, Rotterdam, The Netherlands.|Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
Adriaan
A
Coenen
Department of Radiology, Erasmus MC, 's-Gravendijkwal 230, Room: Ca-207a, 3015 CE, Rotterdam, The Netherlands.|Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
Marisa M
MM
Lubbers
Department of Radiology, Erasmus MC, 's-Gravendijkwal 230, Room: Ca-207a, 3015 CE, Rotterdam, The Netherlands.
Piotr A
PA
Wielopolski
Department of Radiology, Stanford University, Stanford, CA, USA.
Shreyas S
SS
Vasanawala
Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
Jolien W
JW
Roos-Hesselink
Department of Radiology, Erasmus MC, 's-Gravendijkwal 230, Room: Ca-207a, 3015 CE, Rotterdam, The Netherlands.|Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.
Koen
K
Nieman
D000328:Adult; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000473:pathology; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index