Association of multiple genetic variants with chronic obstructive pulmonary disease susceptibility in Hainan region.
OBJECTIVE
Recent genome-wide association studies have shown associations between variants in loci (4q28.1, 6p21.32, 6p21.1, 6q16.1, 10q22.1 and 10q22.3) and chronic obstructive pulmonary disease (COPD) or smoking behaviors. The objective of this study was to look for associations between 16 single nucleotide polymorphisms (SNP) at these six loci and COPD susceptibility in Hainan region.


METHODS
A case-control cohort was composed of 200 COPD cases and 401 controls that were genotyped and analyzed statistically. Odds ratios (OR) and 95% confidence intervals (CIs) were computed by chi-square (χ2) test and genetic models by unconditional logistic regression.


RESULTS
After Hardy-Weinberg equilibrium (HWE) P value screening, we excluded the SNP rs12220777 with P < 0.001. By χ2test only rs9296092 which located on 6p21.32 was provided the strongest evidence of an increasing risk of COPD with an OR of 3.28 (95% CI = 1.03 - 2.32; P = 0.003) between cases and controls. By genetic models analysis, we not only found rs9296092 increased COPD risk, but also found in the over-dominant model the genotype 'C/T' (OR = 0.55; 95% CI = 0.33 - 0.93; P = 0.023) of rs950063 was proved to be associated with decreased COPD risk.


CONCLUSIONS
This study is the first to provide evidence of importance of rs9296092 and rs950063 for risk of COPD in Hainan Province. Further studies are needed to characterize the functional sequences that cause COPD.
Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, 570311, China.
Yipeng
Y
Ding
Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, 570311, China.
Huan
H
Niu
School of Life Sciences, Northwest University, Xi'an, 710069, China.
Long
L
Zhou
School of Life Sciences, Northwest University, Xi'an, 710069, China.
Wenjing
W
Zhou
Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, 570311, China.
Jiannan
J
Chen
Department of Respiration, People's Hospital of Lingao, Lingao, Hainan, 571400, China.
Shiliang
S
Xie
National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China.
Tingting
T
Geng
Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, 570311, China.
Yanhong
Y
Ouyang
Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, 570311, China.
Ping
P
He
Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, 570311, China.
Pei
P
Sun
National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China.
Tian
T
Feng
School of Life Sciences, Northwest University, Xi'an, 710069, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China.
Tianbo
T
Jin
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D015994:Incidence; D008019:Life Style / Q000208:ethnology; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D012306:Risk; D012907:Smoking / Q000235:genetics
case-control study - chronic obstructive pulmonary disease - genetic association - Hainan region - single nucleotide polymorphisms