Association between serum uric acid and bone health in general population: a large and multicentre study.
Previous studies proposed that serum uric acid (UA), an endogenous antioxidant, could be a protective factor against bone loss. However, recently, a study with a population of US adults did not note the protective effects of serum UA. Therefore, the exact association between serum UA and bone health remains unclear. We performed a retrospective consecutive cohort study in a Chinese population to examine the association between serum UA and bone health. This cross-sectional study included 17,735 individuals who underwent lumbar spine bone mineral density (BMD) measurements as part of a health examination. In covariance analyses (multivariable-adjusted), a high serum UA level was associated with a high BMD, T-score, and Z-score. In binary logistic regression analyses (multivariable-adjusted), a high serum UA level was associated with low odds ratios (ORs) for at least osteopenia and osteoporosis in male (age ≥50 years) (OR = 0.72-0.60 and OR = 0.49-0.39, respectively) and postmenopausal female participants (OR = 0.61-0.51 and OR = 0.66-0.49, respectively). In conclusion, serum UA is associated with BMD, the T-score, and the Z-score, and has a strong protective effect against at least osteopenia and osteoporosis.
Department of Orthopedics Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
Xianfeng
X
Lin
Department of Orthopedics Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
Chenchen
C
Zhao
Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
An
A
Qin
Department of Orthopedics Surgery, Taizhou Hospital of Wenzhou Medical University, Linhai, China.
Dun
D
Hong
Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wenyue
W
Liu
Department of Orthopedics Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
Kangmao
K
Huang
Department of Orthopedics Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
Jian
J
Mo
Department of Orthopedics Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
Hejun
H
Yu
Department of Cardiology, The Key Laboratory of Cardiovascular Disease of Wenzhou, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Shengjie
S
Wu
Department of Orthopedics Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
Shunwu
S
Fan
D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid
DXA; Gerotarget; bone health; bone mass loss; bone mineral density; serum uric acid