Association of Serum Ferritin Levels with Metabolic Syndrome and Insulin Resistance.
BACKGROUND
The impact of CVDs and Type II DM is increasing over the last decade. It has been estimated that by 2025 their incidence will double. Ferritin is one of the key proteins regulating iron homeostasis and is a widely available clinical biomarker of iron status. Some studies suggest that prevalence of atherosclerosis and insulin resistance increases significantly with increasing serum ferritin. Metabolic syndrome is known to be associated with increased risk of atherosclerosis as well as insulin resistance.


OBJECTIVE
The present study was designed to explore the association of serum ferritin levels with metabolic syndrome and insulin resistance.


METHODS
The present study was prospective, cross sectional. The study protocol was approved by IEC. The study group consisted of 90 participants (50 cases of metabolic syndrome and 40 age and sex matched controls). Diagnosis of metabolic syndrome was done as per NCEP ATP III criteria. Estimation of serum Ferritin and Insulin was done by Chemiluminescence Immunoassay (CLIA) while Glucose by Glucose Oxidase and Peroxidase (GOD-POD) method. Insulin Resistance was calculated by HOMA IR score.


METHODS
Data obtained was statistically analysed by using student t-test.


RESULTS
We found statistically significant rise in the levels of serum ferritin (p=<0.001), glucose (p=<0.001), insulin (p=<0.001) and HOMA IR score (p=<0.0001) in cases of metabolic syndrome as compared with controls.


CONCLUSIONS
High serum ferritin levels though within normal range are significantly associated with both metabolic syndrome and insulin resistance.
Professor, Department of Biochemistry, Bharati Vidyapeeth University Medical College , Pune, India .
Meghana K
MK
Padwal
Student, Bharati Vidyapeeth University Medical College , Pune, India .
Mohsin
M
Murshid
Junior Resident, Department of Biochemistry, Bharati Vidyapeeth University Medical College , Pune, India .
Prachee
P
Nirmale
Professor and Head, Department of Biochemistry, Bharati Vidyapeeth University Medical College , Pune, India .
R R
RR
Melinkeri
HOMA-IR; Iron overload; Type II DM