Acute Hepatocellular Drug-Induced Liver Injury From Bupropion and Doxycycline.
The management and diagnosis of drug-induced liver injury (DILI) is often challenging, particularly when patients are taking multiple medications. We present a 29-year-old African American man who presented with jaundice and malaise after starting bupropion and doxycycline 2 weeks prior. He was found to have acute hepatocellular drug-induced liver injury with autoimmune features, and made a complete recovery with prednisone. Although bupropion and doxycycline are both known to cause liver toxicity, a closer inspection of the signature of liver injury and a review of prior related DILI cases assigns causality more to bupropion than doxycycline.
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Derek M
DM
Tang
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD ; Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Christopher
C
Koh
Division of Pathology, University of Maryland School of Medicine, Baltimore, MD.
William S
WS
Twaddell
Veterans Affairs Maryland Health Center, Baltimore, MD ; Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD.
Erik C
EC
von Rosenvinge
Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD.
Hyosun
H
Han