Prevention of Capsular Contracture Using Leukotriene Antagonists.
BACKGROUND
Capsular contracture is a common occurrence in plastic surgery, with a prevalence varying from 0.5 percent up to 30 percent. Although the standard treatment is capsulectomy, alternative treatments have been studied, such as the use of leukotriene inhibitors. These drugs have recently been evaluated in the prophylaxis of contracture. The authors aimed to assess the efficacy of montelukast (Singulair) in the prevention of capsular contracture in patients undergoing mammaplasty with textured silicone prostheses.


METHODS
The authors followed 82 patients (164 breasts) for a minimum of 2 years. Of these, 37 were administered montelukast.


RESULTS
The number of affected patients and the severity were higher among the 45 patients who did not use montelukast.


CONCLUSIONS
The prophylactic use of Singulair was, in this sample, shown to be effective in helping to reduce the incidence of capsular contracture.


METHODS
Therapeutic, III.
Curitiba, Paraná, Brazil From the Division of Plastic and Reconstructive Surgery, Hospital de Clínicas, Federal University of Paraná.
Ruth
R
Graf
Adriana S K
ASK
Ascenço
Renato da S
RDS
Freitas
Priscilla
P
Balbinot
Carolina
C
Peressutti
Diogo F B
DFB
Costa
Fábio de H C R
FHCR
Dos Santos
Marco A S
MAS
Ratti
Rodrigo M
RM
Kulchetscki
D000085:Acetates / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D001938:Brazil; D018427:Breast Implants / Q000009:adverse effects*; D015331:Cohort Studies; D003521:Cyclopropanes; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D057910:Implant Capsular Contracture / Q000517:prevention & control*; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D016015:Logistic Models; D016462:Mammaplasty / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D015999:Multivariate Analysis; D011322:Primary Prevention / Q000379:methods; D011804:Quinolines / Q000627:therapeutic use*; D012189:Retrospective Studies; D018570:Risk Assessment; D013440:Sulfides; D016896:Treatment Outcome; D055815:Young Adult
D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast