Differentiation of high-grade-astrocytomas from solitary-brain-metastases: Comparing diffusion kurtosis imaging and diffusion tensor imaging.
OBJECTIVE
To compare the value of MRI diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) in differentiating high-grade-astrocytomas from solitary-brain-metastases.


METHODS
Thirty-one high-grade-astrocytomas and twenty solitary-brain-metastases were retrospectively identified. DKI parameters [mean kurtosis (MK), radial kurtosis (Kr), and axial kurtosis (Ka)] and DTI parameters [fractional anisotropy (FA) and mean diffusivity (MD)] values with and without correction by contralateral normal-appearing white matter (NAWM) in the tumoral solid part and peritumoral edema, were compared using the t-test. Receiver operating characteristic (ROC) curves were used to test for the best parameters.


RESULTS
The DKI values (MK, Kr, and Ka) and DTI values (FA and MD) in tumoral solid parts did not show significant differences between the two groups. Corrected and uncorrected MK, Kr, and Ka values in peritumoral edema were significantly higher in high-grade-astrocytomas than solitary-brain-metastases, and MD values without correction were lower in high-grade astrocytomas than solitary-brain-metastases. The areas under curve (AUC) of corrected Ka (1.000), MK (0.889), and Kr (0.880) values were significantly higher than those of MD (0.793) and FA (0.472) values. The optimal thresholds for corrected MK, Kr, Ka, and MD were 0.369, 0.405, 0.483, and 2.067, respectively.


CONCLUSIONS
DKI and directional analysis could lead to improved differentiation with better sensitivity and directional specificity than DTI.
Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 Shanxi Province, China.
Yan
Y
Tan
Department of Medical Imaging, Shanxi Medical University, Taiyuan, 030001 Shanxi Province, China.
Xiao-Chun
XC
Wang
Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 Shanxi Province, China. Electronic address: zhanghui_mr@163.com.
Hui
H
Zhang
Department of Medical Imaging, Shanxi Medical University, Taiyuan, 030001 Shanxi Province, China. Electronic address: cjr.wangjun@vip.163.com.
Jun
J
Wang
Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 Shanxi Province, China.
Jiang-Bo
JB
Qin
Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 Shanxi Province, China.
Xiao-Feng
XF
Wu
Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 Shanxi Province, China.
Lei
L
Zhang
Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, 030001 Shanxi Province, China.
Le
L
Wang
D000328:Adult; D000368:Aged; D016880:Anisotropy; D019540:Area Under Curve; D001254:Astrocytoma / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D003937:Diagnosis, Differential; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
Diffusion kurtosis imaging; Diffusion tensor imaging; High-grade astrocytomas; Solitary brain metastases