Minimally fibrotic stage 5 ROP: a clinical prognostic factor in eyes undergoing vitrectomy for stage 5 retinopathy of prematurity.
BACKGROUND
Minimally fibrotic Stage 5: A clinical prognostic factor in eyes undergoing vitrectomy for stage 5 retinopathy of prematurity (ROP).


OBJECTIVE
To define minimally fibrotic stage 5 ROP and to demonstrate better surgical outcomes in this subgroup.


METHODS
A cohort of eligible eyes with stage 5 ROP undergoing vitrectomy were further divided into those with minimally fibrotic stage 5 and others. Minimally fibrotic stage 5 ROP was defined as those stage 5 eyes having a translucent retrolental membrane with visibility of the underlying retinal vessels and absence of anteriorly rotated ciliary processes. We reported on anatomic and visual outcomes in eyes with defined characteristics of this subgroup identified before surgery and then observing them post vitrectomy over a period of time as compared to others.


RESULTS
Minimally fibrotic stage 5 eyes had better visual (p = .0068) and anatomical outcomes (p = .0001).


CONCLUSIONS
Minimally fibrotic stage 5 ROP shows ridge to ridge traction that has resulted in a traction retinal detachment with a retrolental membrane, but fibrotic change has just begun. This stage 5 ROP with limited fibrosis represents a subset of this stage 5 ROP with a positive anatomic and visual prognosis.
Department of Vitreoretina surgery, PBMA's H V Desai Eye Hospital, Hadapsar, Pune, 411060, India. drgadkari@gmail.com.
Salil S
SS
Gadkari
Department of Vitreoretina surgery, PBMA's H V Desai Eye Hospital, Hadapsar, Pune, 411060, India.
Madan
M
Deshpande
Department of Vitreoretina surgery, PBMA's H V Desai Eye Hospital, Hadapsar, Pune, 411060, India.
Sucheta
S
Kulkarni
D005260:Female; D005355:Fibrosis / Q000473:pathology; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012160:Retina / Q000473:pathology*; D012178:Retinopathy of Prematurity / Q000175:diagnosis / Q000601:surgery*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods*
Minimally fibrotic Stage 5 ROP; Stage 5 ROP; Vitrectomy for ROP