Expression of Stem Cell Markers in Preinvasive Tubal Lesions of Ovarian Carcinoma.
In order to better understand the ovarian serous carcinogenic process with tubal origin, we investigated the expression of stem cell markers in premalignant tubal lesions (serous tubal intraepithelial carcinoma or STIC). We found an increased stem cell marker density in the normal fallopian tube followed by a high CD117 and a low ALDH and CD44 expression in STICs raising the question of the role of the stem cell markers in the serous carcinogenic process.
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H2X 0A9 ; Institut du Cancer de Montréal, Montreal, QC, Canada H2X 0A9 ; Department of Gynecology, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France ; Université Claude Bernard Lyon 1, EMR 3738, 69000 Lyon, France.
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Chene
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H2X 0A9 ; Institut du Cancer de Montréal, Montreal, QC, Canada H2X 0A9.
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Ouellet
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H2X 0A9 ; Institut du Cancer de Montréal, Montreal, QC, Canada H2X 0A9 ; Department of Pathology, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montreal, QC, Canada H2X 0A9.
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Rahimi
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H2X 0A9 ; Institut du Cancer de Montréal, Montreal, QC, Canada H2X 0A9.
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Barres
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H2X 0A9 ; Institut du Cancer de Montréal, Montreal, QC, Canada H2X 0A9.
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Meunier
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H2X 0A9 ; Institut du Cancer de Montréal, Montreal, QC, Canada H2X 0A9.
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De Ladurantaye
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H2X 0A9 ; Institut du Cancer de Montréal, Montreal, QC, Canada H2X 0A9 ; Division of Gynecologic Oncology, Université de Montréal, Montreal, QC, Canada H2X 0A9.
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Provencher
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H2X 0A9 ; Institut du Cancer de Montréal, Montreal, QC, Canada H2X 0A9 ; Department of Medicine, Université de Montréal, Montreal, QC, Canada H2X 0A9.
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Mes-Masson
D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D005185:Fallopian Tube Neoplasms / Q000737:chemistry* / Q000378:metabolism; D005187:Fallopian Tubes / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis / Q000378:metabolism; D046888:Tissue Array Analysis
D014408:Biomarkers, Tumor; C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D019009:Proto-Oncogene Proteins c-kit