Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder.
OBJECTIVE
We tested for association of the catechol-O-methyltransferase (COMT) Val(158)-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios.


METHODS
A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios.


RESULTS
In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ(2)=4.21, p=0.040).


CONCLUSIONS
These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.
Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea.
Subin
S
Park
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Jong-Eun
JE
Park
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Hee Jeong
HJ
Yoo
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Jae-Won
JW
Kim
Uimyung Research Institute for Neuroscience, Sahmyook University, Seoul, Republic of Korea.
Jae Hoon
JH
Cheong
Department of Psychiatry, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Doug Hyun
DH
Han
Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea.
Yeni
Y
Kim
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Bung-Nyun
BN
Kim
Attention-deficit hyperactivity disorder; COMT