Simultaneous inference of haplotypes and alleles at a causal gene.
We present a methodology which jointly infers haplotypes and the causal alleles at a gene influencing a given trait. Often in human genetic studies, the available data consists of genotypes (series of genetic markers along the chromosomes) and a phenotype. However, for many genetic analyses, one needs haplotypes instead of genotypes. Our methodology is not only able to estimate haplotypes conditionally on the disease status, but is also able to infer the alleles at the unknown disease locus. Some applications of our methodology are in genetic mapping and in genetic counseling.
Département de Mathématiques, Université du Québec à Montréal Montréal, QC, Canada.
Fabrice
F
Larribe
Département d'informatique et de recherche opérationnelle, Université de Montréal Montréal, QC, Canada.
Mathieu J
MJ
Dupont
Montreal Heart Institute Montréal, QC, Canada.
Gabrielle
G
Boucher
EM algorithm; causal allele inference; haplotype estimation; linkage disequilibrium