Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides.
A regio- and stereoselective synthesis of highly substituted α-haloenamides was described via the zinc halide mediated direct addition of benzhydryl halides to ynamides under mild conditions. The products α-haloenamides were further transformed into multisubstituted enamides via Suzuki and Sonogashira cross-coupling reactions.
Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, No. 1378, Wenyi West Road, Science Park of HZNU, Hangzhou, P.R. China. caojian@hznu.edu.cn.
Ling
L
Chen
Lian
L
Yu
Yuan
Y
Deng
Yuming
Y
Cui
Gaofeng
G
Bian
Jian
J
Cao