Noninvasive Fractional Flow Reserve Derived From Coronary CT Angiography: Clinical Data and Scientific Principles.
Fractional flow reserve derived from coronary computed tomography angiography enables noninvasive assessment of the hemodynamic significance of coronary artery lesions and coupling of the anatomic severity of a coronary stenosis with its physiological effects. Since its initial demonstration of feasibility of use in humans in 2011, a significant body of clinical evidence has developed to evaluate the diagnostic performance of coronary computed tomography angiography-derived fractional flow reserve compared with an invasive fractional flow reserve reference standard. The purpose of this paper was to describe the scientific principles and to review the clinical data of this technology recently approved by the U.S. Food and Drug Administration.
Departments of Radiology and Medicine, Weill Cornell Medical College, New York, New York; Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, New York, New York. Electronic address: jkm2001@med.cornell.edu.
James K
JK
Min
HeartFlow, Inc., Redwood City, California; Department of Bioengineering, Stanford University, Stanford, California.
Charles A
CA
Taylor
Department of Cardiology, Erlangen University Hospital, Erlangen, Germany.
Stephan
S
Achenbach
Department of Medicine, Seoul National University Hospital, Seoul, South Korea.
Bon Kwon
BK
Koo
Department of Radiology, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Jonathon
J
Leipsic
Department of Medicine, Weill Cornell Medical Center, New York, New York; Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark.
Bjarne L
BL
Nørgaard
Catharina Hospital, Eindhoven, the Netherlands.
Nico J
NJ
Pijls
Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium.
Bernard
B
De Bruyne
D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D053805:Fractional Flow Reserve, Myocardial; D006439:Hemodynamics; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed
FFR(CT); coronary CTA; coronary artery disease; fractional flow reserve; ischemia