title: The first 50 live births after autologous oocyte vitrification in France.
abstract: OBJECTIVE
  The study aims to describe the newborn health parameters of the 50 first children conceived after autologous oocyte vitrification in France.
  
  
  METHODS
  The 50 children born after autologous oocyte vitrification/warming cycle (VAO children) have been retrospectively compared with 364 children conceived by micromanipulation using freshly recovered non-vitrified oocytes (ICSI children). Children included in the study were born between 2011 and 2015. Maternal characteristics (age, body mass index, smoking habits), obstetric outcomes (diabetes, hypertension, placenta previa, parity, mode of delivery), and perinatal outcome (twinning, sex, birth weight, macrosomia, birth defects) were analyzed. The generalized estimating equation for correlated data was performed to evaluate perinatal outcomes and caesarean section.
  
  
  RESULTS
  No statistically significant difference was found between VAO children and ICSI children, even after adjusting confounding factors (low birth weigh odds ratio (OR) 0.8, 95 % confident interval (CI) 0.3-2.2, adjusted (AOR) 0.5, 95 % CI 0.2-1.7; large for gestational age OR 1.5, 95 % CI 0.3-7.0, AOR 1.6, 95 % CI 0.3-7.5; birth defects OR 0.4, 95 % CI 0.1-3.2, AOR 0.5, 95 % CI 0.1-3.7; caesarean section OR 1.8, 95 % CI 0.9-3.4, AOR 1.8, 95 % CI 0.9-3.7).
  
  
  CONCLUSIONS
  According to our results, newborn health parameters of children conceived in our center by micromanipulation using vitrified/warmed autologous oocytes seem not to be different from children born after micromanipulation on freshly recovered oocytes.
authors.affiliation: Service de Médecine et Biologie de la Reproduction, Hôpital Saint Joseph, 13008, Marseille, France. beltran_any@yahoo.com.|Département de Santé Publique et Maladies Chroniques, Aix-Marseille Université, Faculté de médecine, Unité de recherche EA 3279, 13005, Marseille, France. beltran_any@yahoo.com.
authors.forename: Any Beltran
authors.initials: AB
authors.lastname: Anzola
authors.affiliation: Département de Santé Publique et Maladies Chroniques, Aix-Marseille Université, Faculté de médecine, Unité de recherche EA 3279, 13005, Marseille, France.|Service d'information médicale, Assistance Publique Hôpitaux de Marseille, 13009, Marseille, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Pauly
authors.affiliation: Service de Médecine et Biologie de la Reproduction, Hôpital Saint Joseph, 13008, Marseille, France.
authors.forename: Cendrine
authors.initials: C
authors.lastname: Geoffroy-Siraudin
authors.affiliation: Service de Médecine et Biologie de la Reproduction, Hôpital Saint Joseph, 13008, Marseille, France.
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: Gervoise-Boyer
authors.affiliation: Service de Médecine et Biologie de la Reproduction, Hôpital Saint Joseph, 13008, Marseille, France.
authors.forename: Debbie
authors.initials: D
authors.lastname: Montjean
authors.affiliation: Service de Médecine et Biologie de la Reproduction, Hôpital Saint Joseph, 13008, Marseille, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Boyer
mesh_terms: D015925:Cryopreservation / Q000379:methods*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D050498:Live Birth; D009865:Oocytes; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D058989:Vitrification
keywords: Autologous oocytes; Children health; Retrospective study; Vitrification