title: Critical analysis of experimental model for study of adhesions after incisional hernias induced in rats' and repair of abdominal wall with different biomaterials.
abstract: BACKGROUND
  Adhesions induced by biomaterials experimentally implanted in the abdominal cavity are basically studied by primary repair of different abdominal wall defects or by the correction of incisional hernias previously performed with no precise definition of the most appropriate model.
  
  
  OBJECTIVE
  To describe the adhesions which occur after the development of incisional hernias, before the prosthesis implantation, in an experimental model to study the changes induced by different meshes.
  
  
  METHODS
  Incisional hernias were performed in 10 rats with hernia orifices of standardized dimensions, obtained by the median incision of the abdominal wall and eversion of the defect edges. Ten days after the procedure adhesions of abdominal structures were found when hernias were repaired with different meshes.
  
  
  RESULTS
  The results showed hernia sac well defined in all rats ten days after the initial procedure. Adhesions of the greater omentum occurred in five animals of which two also showed adhesions of small bowel loops besides the omentum, and another two showed liver adhesions as well as the greater omentum, numbers with statistical significance by Student's t test (p<0.05).
  
  
  CONCLUSIONS
  Although it reproduces the real clinical situation, the choice of experimental model of incisional hernia repair previously induced implies important adhesions, with possible repercussions in the evaluation of the second operation, when different implants of synthetic materials are used.
authors.affiliation: University Nove de Julho, University Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Leonardo Carvalho
authors.initials: LC
authors.lastname: Serigiolle
authors.affiliation: University Nove de Julho, University Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Renato Lamounier
authors.initials: RL
authors.lastname: Barbieri
authors.affiliation: University Nove de Julho, University Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Helbert Minuncio Pereira
authors.initials: HM
authors.lastname: Gomes
authors.affiliation: University Nove de Julho, University Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Daren Athiê Boy
authors.initials: DA
authors.lastname: Rodrigues
authors.affiliation: University Nove de Julho, University Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Sarah do Valle
authors.initials: Sdo V
authors.lastname: Studart
authors.affiliation: University Nove de Julho, University Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Pedro Luiz Squilacci
authors.initials: PL
authors.lastname: Leme
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D004195:Disease Models, Animal; D000069290:Incisional Hernia / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials