title: Enhancing Effect of Intermittent Parathyroid Hormone Administration on Bone Formation After Titanium Implant Placement in an Ovariectomized Rat Maxilla.
abstract: OBJECTIVE
  This study examined the effect of intermittent parathyroid hormone (PTH) administration on the bone response around implant on the maxilla of rats with ovariectomy-induced osteoporosis.
  
  
  METHODS
  A total of 27 female Sprague-Dawley rats were divided into 3 groups (n = 9) and were ovariectomized (OVX). Eight weeks after, upper right molar was extracted and an implant was placed at 4 weeks after extraction. The PTH group received PTH, and the OVX group and the control group received vehicle only. Beginning after implant placement, 30 μg/kg of PTH was subcutaneously administered in the dorsum 3 times a week. Three rats in each group were killed at 1, 2, and 4 weeks and histologic sections were evaluated.
  
  
  RESULTS
  After 4 weeks, the amount of newly formed bone around implants in the PTH group was comparable with the control group, with bone covering the implant surface in both groups. However, the OVX group displayed relatively small amount of new bone.
  
  
  CONCLUSIONS
  Intermittent PTH has the potential to increase new bone formation around implant. These findings have clinical implications in prosthetic restoration by implants with poor bone quality.
authors.affiliation: *Assistant Professor, Department of Oral and Maxillofacial Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea. †Assistant Professor, Department of Oral and Maxillofacial Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea. ‡Graduate Student, Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dental Science, The Catholic University of Korea, Seoul, Korea. §Professor, Department of Oral and Maxillofacial Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Hyun-A
authors.initials: HA
authors.lastname: Heo
authors.forename: Su-hyun
authors.initials: SH
authors.lastname: Park
authors.forename: Yoon-sik
authors.initials: YS
authors.lastname: Jeon
authors.forename: Sung-woon
authors.initials: SW
authors.lastname: Pyo
mesh_terms: D000818:Animals; D000069343:Bone-Implant Interface / Q000254:growth & development / Q000503:physiopathology; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D005260:Female; D008437:Maxilla / Q000601:surgery; D016348:Osseointegration / Q000187:drug effects* / Q000502:physiology; D010052:Ovariectomy; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014025:Titanium
chemical_list: D015921:Dental Implants; D010281:Parathyroid Hormone; D014025:Titanium