title: Recent advances in superparamagnetic iron oxide nanoparticles (SPIONs) for in vitro and in vivo cancer nanotheranostics.
abstract: Recently superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used in cancer therapy and diagnosis (theranostics) via magnetic targeting, magnetic resonance imaging, etc. due to their remarkable magnetic properties, chemical stability, and biocompatibility. However, the magnetic properties of SPIONs are influenced by various physicochemical and synthesis parameters. So, this review mainly focuses on the influence of spin canting effects, introduced by the variations in size, shape, and organic/inorganic surface coatings, on the magnetic properties of SPIONs. This review also describes the several predominant chemical synthesis procedures and role of the synthesis parameters for monitoring the size, shape, crystallinity and composition of the SPIONs. Moreover, this review discusses about the latest developments of the inorganic materials and organic polymers for encapsulation of the SPIONs. Finally, the most recent advancements of the SPIONs and their nanopackages in combination with other imaging/therapeutic agents have been comprehensively discussed for their effective usage as in vitro and in vivo theranostic agents in cancer treatments.
authors.affiliation: Nanomaterials Lab, Department of Mechanical Engineering, Shiv Nadar University, Uttar Pradesh 201314, India.
authors.forename: Ganeshlenin
authors.initials: G
authors.lastname: Kandasamy
authors.affiliation: Nanomaterials Lab, Department of Mechanical Engineering, Shiv Nadar University, Uttar Pradesh 201314, India. Electronic address: dipak.maity@snu.edu.in.
authors.forename: Dipak
authors.initials: D
authors.lastname: Maity
mesh_terms: D000818:Animals; D005290:Ferric Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D013499:Surface Properties / Q000187:drug effects; D000068936:Theranostic Nanomedicine / Q000379:methods* / Q000639:trends
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide
keywords: Cancer theranostics; Hyperthermia; Magnetic nanoparticles; Magnetic resonance imaging; Spin canting; Superparamagnetic iron oxide; Synthesis and surface engineering