title: Update on mesenchymal stem cell-based therapy in lupus and scleroderma.
abstract: Current systemic therapies are rarely curative for patients with severe life-threatening forms of autoimmune diseases (ADs). During the past 15 years, autologous hematopoietic stem cell transplantation has been demonstrated to cure some patients with severe AD refractory to all other available therapies. As a consequence, ADs such as lupus and scleroderma have become an emerging indication for cell therapy. Multipotent mesenchymal stem cells (MSCs), isolated from bone marrow and other sites, display specific immunomodulation and anti-inflammatory properties and appear as ideal tools to treat such diseases. The present update aims at summarizing recent knowledge acquired in the field of MSC-based therapies for lupus and scleroderma.
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Cell Therapy Unit, Cord blood Bank and CIC-BT501, 1 avenue Claude Vellefaux, 75010, Paris, France. audrey.cras@sls.aphp.fr.|INSERM UMRS 1140, Paris Descartes, Faculté de Pharmacie, 4 avenue de l'observatoire, 75004, Paris, France. audrey.cras@sls.aphp.fr.
authors.forename: Audrey
authors.initials: A
authors.lastname: Cras
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Internal Medicine and Vascular Disease Unit, CIC-BT501, INSERM UMRS 1160, Paris 7 Diderot University, Sorbonne Paris Cité, 1 avenue Claude Vellefaux, 75010, Paris, France. dominique.farge-bancel@sls.aphp.fr.
authors.forename: Dominique
authors.initials: D
authors.lastname: Farge
authors.affiliation: Hôpital du Val de Grace, Internal Medecine Unit, 74 boulevard de Port Royal, 75005, Paris, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Carmoi
authors.affiliation: Percy Military Hospital, Department of Research and Cell Therapy, 101 Avenue Henri Barbusse, 92140, Clamart, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Lataillade
authors.affiliation: Department of Immunology, The affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhong Shan Road, Nanjing, 210008, China.
authors.forename: Dan Dan
authors.initials: DD
authors.lastname: Wang
authors.affiliation: Department of Immunology, The affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhong Shan Road, Nanjing, 210008, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Sun
mesh_terms: D000818:Animals; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D051379:Mice; D039902:Multipotent Stem Cells / Q000276:immunology*; D012074:Remission Induction; D012595:Scleroderma, Systemic / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome