title: Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
abstract: BACKGROUND
  There may be differences in the antitumor immunity induced by dendritic cells (DCs) during the development of squamous cell carcinoma (SCC) located in the lip rather than in the oral cavity. The aim of this study was to evaluate the number of immature and mature DCs in SCC and potentially malignant disorders of the oral cavity and lip.
  
  
  METHODS
  Immunohistochemistry was used to identify the number (cells/mm(2) ) of immature (CD1a(+) ) or mature (CD83(+) ) DCs in samples of oral cavity SCC (OCSCC) (n = 39), lip SCC (LSCC) (n = 23), leukoplakia (LK) (n = 21), actinic cheilitis (AC) (n = 13), and normal mucosa of the oral cavity (OC control, n = 12) and the lip (lip control, n = 11).
  
  
  RESULTS
  The number of CD1a(+) cells tended to be higher in the OC control samples compared with the LK (P = 0.04) and OCSCC (P = 0.21). Unlike, this cell population was lower in the lip control than in AC or LSCC (P < 0.05). The number of CD83(+) cells was increased in the LSCC samples compared with the AC and lip control (P = 0.0001) and in OCSCC compared with both the LK (P = 0.001) and OC control (P = 0.0001) samples. LSCC showed an elevated number of CD1a(+) and CD83(+) cells compared with OCSCC (P = 0.03). The population of mature DCs was lower than the population of immature DCs in all of the tested groups (P < 0.05).
  
  
  CONCLUSIONS
  There were a greater number of both mature and immature DC populations in the LSCC samples than in the OCSCC, which could contribute to establishing a more effective immune antitumor response for this neoplasm.
authors.affiliation: Department of Oral Medicine (Oral Pathology, Stomatology and Radiology), School of Dentistry, Federal University of Goiás, Goiânia, Brazil.
authors.forename: Nádia Lago
authors.initials: NL
authors.lastname: Costa
authors.affiliation: Department of Oral Medicine (Oral Pathology, Stomatology and Radiology), School of Dentistry, Federal University of Goiás, Goiânia, Brazil.
authors.forename: Andréia Souza
authors.initials: AS
authors.lastname: Gonçalves
authors.affiliation: Department of Oral Medicine (Oral Pathology, Stomatology and Radiology), School of Dentistry, Federal University of Goiás, Goiânia, Brazil.
authors.forename: Allisson Filipe Lopes
authors.initials: AF
authors.lastname: Martins
authors.affiliation: Department of Oral Medicine (Oral Pathology, Stomatology and Radiology), School of Dentistry, Federal University of Goiás, Goiânia, Brazil.
authors.forename: Diego Antônio Costa
authors.initials: DA
authors.lastname: Arantes
authors.affiliation: Department of Oral Surgery and Pathology, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Tarcília Aparecida
authors.initials: TA
authors.lastname: Silva
authors.affiliation: Department of Oral Medicine (Oral Pathology, Stomatology and Radiology), School of Dentistry, Federal University of Goiás, Goiânia, Brazil.
authors.forename: Aline Carvalho
authors.initials: AC
authors.lastname: Batista
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D018949:Antigens, CD1 / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D002613:Cheilitis / Q000378:metabolism / Q000473:pathology; D003430:Cross-Sectional Studies; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007971:Leukoplakia / Q000378:metabolism / Q000473:pathology; D008048:Lip Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate; D000097802:CD83 Antigen
chemical_list: D015703:Antigens, CD; D018949:Antigens, CD1; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D000097802:CD83 Antigen; C419393:CD1a antigen
keywords: dendritic cell; lip cancer; oral cancer; potentially malignant disorders; squamous cell carcinoma