title: Insular Gray Matter Volume and Objective Quality of Life in Schizophrenia.
abstract: Improving quality of life has been recognized as an important outcome for schizophrenia treatment, although the fundamental determinants are not well understood. In this study, we investigated the association between brain structural abnormalities and objective quality of life in schizophrenia patients. Thirty-three schizophrenia patients and 42 age-, sex-, and education-matched healthy participants underwent magnetic resonance imaging. The Quality of Life Scale was used to measure objective quality of life in schizophrenia patients. Voxel-based morphometry was performed to identify regional brain alterations that correlate with Quality of Life Scale score in the patient group. Schizophrenia patients showed gray matter reductions in the frontal, temporal, limbic, and subcortical regions. We then performed voxel-based multiple regression analysis in these regions to identify any correlations between regional gray matter volume and Quality of Life Scale scores. We found that among four subcategories of the scale, the Instrumental Role category score correlated with gray matter volume in the right anterior insula in schizophrenia patients. In addition, this correlation was shown to be mediated by negative symptoms. Our findings suggest that the neural basis of objective quality of life might differ topographically from that of subjective QOL in schizophrenia.
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.|Kyoto University Health Service, Kyoto, Japan.
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Uwatoko
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Yoshizumi
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Miyata
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Shiho
authors.initials: S
authors.lastname: Ubukata
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.|Kyoto University Hospital Integrated Clinical Education Center, Kyoto, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Fujiwara
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Ryosaku
authors.initials: R
authors.lastname: Kawada
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.|Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kubota
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sasamoto
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Genichi
authors.initials: G
authors.lastname: Sugihara
authors.affiliation: Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Aso
authors.affiliation: Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Urayama
authors.affiliation: Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Murai
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008297:Male; D009929:Organ Size; D011788:Quality of Life; D012559:Schizophrenia / Q000473:pathology*