title: Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program.
abstract: OBJECTIVE
  We examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations.
  
  
  METHODS
  The study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1.
  
  
  RESULTS
  In cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % [95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (p < 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight.
  
  
  CONCLUSIONS
  Our study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Box 268, 800, Washington Street, #268, Boston, MA, 02111, USA. lisa.ceglia@tufts.edu.|Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. lisa.ceglia@tufts.edu.
authors.forename: Lisa
authors.initials: L
authors.lastname: Ceglia
authors.affiliation: Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Nelson
authors.affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
authors.forename: James
authors.initials: J
authors.lastname: Ware
authors.affiliation: Division of Neurology, Boston University Medical Center, Boston, MA, USA.
authors.forename: Konstantinos-Dionysios
authors.initials: KD
authors.lastname: Alysandratos
authors.affiliation: Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
authors.forename: George A
authors.initials: GA
authors.lastname: Bray
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainsville, FL, USA.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Garganta
authors.affiliation: Diabetes Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Nathan
authors.affiliation: Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA.|Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Box 268, 800, Washington Street, #268, Boston, MA, 02111, USA.|Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: Bess
authors.initials: B
authors.lastname: Dawson-Hughes
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Box 268, 800, Washington Street, #268, Boston, MA, 02111, USA.
authors.forename: Anastassios G
authors.initials: AG
authors.lastname: Pittas
mesh_terms: D050154:Adiposity; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008019:Life Style; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D011236:Prediabetic State / Q000097:blood / Q000188:drug therapy; D012621:Seasons; D050507:Subcutaneous Fat, Abdominal / Q000378:metabolism; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055105:Waist Circumference
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Adipose tissue; Body composition; Body weight; Diabetes Prevention Program; Obesity; Vitamin D