title: CCR 20th Anniversary Commentary: Gene-Expression Signature in Breast Cancer--Where Did It Start and Where Are We Now?
abstract: Desmedt and colleagues published two articles, one in the June 1, 2007 issue, and the other in the August 15, 2008, issue of Clinical Cancer Research, that showed gene-expression signatures to be proliferation driven and time dependent, with their prognostic power decreasing with increasing follow-up years. Moreover, the articles showed that immune response is a crucial determinant of prognosis in the HER2-positive and estrogen receptor-negative/HER2-negative subtypes, providing a rationale to further explore the role of the antitumor immune response in these breast cancer subtypes.
authors.affiliation: Departement de Medecine, BrEAST Data Centre, Institut Jules Bordet, Université libre de Bruxelles, Brussels, Belgium.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gingras
authors.affiliation: Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université libre de Bruxelles, Brussels, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Desmedt
authors.affiliation: Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université libre de Bruxelles, Brussels, Belgium. Department of Medical Oncology, Institut Jules Bordet, Université libre de Bruxelles, Brussels, Belgium.
authors.forename: Michail
authors.initials: M
authors.lastname: Ignatiadis
authors.affiliation: Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université libre de Bruxelles, Brussels, Belgium. Department of Medical Oncology, Institut Jules Bordet, Université libre de Bruxelles, Brussels, Belgium. christos.sotiriou@bordet.be.
authors.forename: Christos
authors.initials: C
authors.lastname: Sotiriou
mesh_terms: D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D015398:Signal Transduction; D059467:Transcriptome
chemical_list: D014408:Biomarkers, Tumor