title: Designing Drug Conjugates Based on Sugar Decorated V-Shape and Star Polymethacrylates: Influence of Composition and Architecture of Polymeric Carrier.
abstract: Amphiphilic ethylenediamine (EDA)-functionalized V-shape and star copolymers with centrally placed methyl-α,D-glucopyranoside were designed as nanocarriers. Anticancer doxorubicin (DOX) was conjugated in water via amine groups in copolymers to form ketimine linkers. Variations of arm length and number (40-65 units per arm and 2 vs 3 vs 4 arms), DOX feed amount, and conjugation site content (50-160 units of EDA groups), as responsible for efficiency of drug attachment (10-60 units of conjugated DOX) and its release at various pH (5.0 vs 7.4), were studied to demonstrate potential for drug delivery. Size of conjugate particles (10-195 nm) formed in aqueous solution was strongly dependent on the polymer composition and topology. The broad range of drug amounts (25-95%) were detected by the precipitation method, showing pH sensitivity by some polymeric conjugates with faster DOX release in acidic conditions.
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology , M. Strzody 9, 44-100 Gliwice, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Mielańczyk
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology , M. Strzody 9, 44-100 Gliwice, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Neugebauer
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D065546:Drug Liberation; D005029:Ethylenediamines / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D005029:Ethylenediamines; D011109:Polymethacrylic Acids; D013501:Surface-Active Agents; C030613:polymethacrylic acid; C031234:ethylenediamine; D004317:Doxorubicin