title: Association of Flavin Monooxygenase Gene E158K Polymorphism with Chronic Heart Disease Risk.
abstract: We studied the relationship between the risk of chronic heart disease and FMO3 gene polymorphism E158K analyzed by PCR and restriction fragment length polymorphism (RFLP) analysis. The homozygous 158KK genotype of FMO3 gene is associated with high risk of chronic heart disease in women, but not in men. FMO3 gene polymorphism E158K is a significant predictor of predisposition to chronic heart disease in women.
authors.affiliation: Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Kursk, Russia. olga.bushueva@inbox.ru.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Bushueva
authors.affiliation: Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Kursk, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Bulgakova
authors.affiliation: Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Kursk, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Ivanov
authors.affiliation: Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Kursk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Polonikov
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006331:Heart Diseases / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010105:Oxygenases / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming)
keywords: association; chronic heart disease; flavin-containing monooxygenase 3