title: Verbal Learning Processes in Patients with Glioma of the Left and Right Temporal Lobes.
abstract: Recent research supports the utility of process variables in understanding mechanisms underlying memory impairments. The Hopkins Verbal Learning Test-Revised (HVLT-R) was administered to 84 patients with left (LTL, n = 58) or right temporal lobe glioma (RTL, n = 26) prior to surgical resection. Primary HVLT-R measures of learning and memory and numerous learning process indices were computed. Both groups exhibited frequent memory impairment (>30%), with greater severity in the LTL group. Patients with LTL glioma also exhibited lower semantic clustering scores than RTL patients, which were highly associated with Total Recall (ρ = 0.83) and Delayed Recall (ρ = 0.68). Learning slope and a novel measure of learning efficiency were also significantly associated with primary memory measures, though scores were similar across the LTL and RTL groups. While lesions to either temporal lobe impact verbal memory, semantic encoding appears to depend upon the integrity of LTL structures in particular.
authors.affiliation: Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Kyle R
authors.initials: KR
authors.lastname: Noll
authors.affiliation: Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Weinberg
authors.affiliation: Brain and Spine Institute, Seton Hospital, Austin, TX, USA.
authors.forename: Mateo
authors.initials: M
authors.lastname: Ziu
authors.affiliation: Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA jwefel@mdanderson.org.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Wefel
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D007839:Functional Laterality; D005910:Glioma / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D012660:Semantics; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology; D014706:Verbal Learning; D055815:Young Adult
keywords: Brain tumor; Cognition; Lateralization; Learning and memory; Neoplasm; Temporal lobe