title: Impact of Plasmodium falciparum Coinfection on Longitudinal Epstein-Barr Virus Kinetics in Kenyan Children.
abstract: Endemic Burkitt lymphoma is associated with Epstein-Barr virus (EBV) and Plasmodium falciparum coinfection, although how P. falciparum exposure affects the dynamics of EBV infection is unclear. We have used a modeling approach to study EBV infection kinetics in a longitudinal cohort of children living in regions of high and low malaria transmission in Kenya. Residence in an area of high malaria transmission was associated with a higher rate of EBV expansion during primary EBV infection in infants and during subsequent episodes of EBV DNA detection, as well as with longer episodes of EBV DNA detection and shorter intervals between subsequent episodes of EBV DNA detection. In addition, we found that concurrent P. falciparum parasitemia also increases the likelihood of the first and subsequent peaks of EBV in peripheral blood. This suggests that P. falciparum infection is associated with increased EBV growth and contributes to endemic Burkitt lymphoma pathogenesis.
authors.affiliation: Kirby Institute for Infection and Immunity, UNSW Australia.
authors.forename: Arnold
authors.initials: A
authors.lastname: Reynaldi
authors.affiliation: Sydney School of Public Health, Sydney University, Australia.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Schlub
authors.affiliation: Kenya Medical Research Institute, Kisumu.
authors.forename: Kiprotich
authors.initials: K
authors.lastname: Chelimo
authors.affiliation: Kenya Medical Research Institute, Kisumu.
authors.forename: Peter Odada
authors.initials: PO
authors.lastname: Sumba
authors.affiliation: SUNY Upstate Medical University, Syracuse, New York.
authors.forename: Erwan
authors.initials: E
authors.lastname: Piriou
authors.affiliation: Kenya Medical Research Institute, Kisumu.
authors.forename: Sidney
authors.initials: S
authors.lastname: Ogolla
authors.affiliation: University of Massachusetts Medical School, Worcester.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Moormann
authors.affiliation: SUNY Upstate Medical University, Syracuse, New York.
authors.forename: Rosemary
authors.initials: R
authors.lastname: Rochford
authors.affiliation: Kirby Institute for Infection and Immunity, UNSW Australia.
authors.forename: Miles P
authors.initials: MP
authors.lastname: Davenport
mesh_terms: D019540:Area Under Curve; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007630:Kenya / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000150:complications* / Q000453:epidemiology; D010963:Plasmodium falciparum; D016016:Proportional Hazards Models; D019562:Viral Load; D014779:Virus Replication / Q000502:physiology*
keywords: Burkitt lymphoma; Epstein-Barr virus; P. falciparum malaria; chronic infection; co-infection; infection dynamics