title: [Analysis and prognostic factors of the specimen of radical prostatectomy in prostate cancer].
abstract: OBJECTIVE
  Handling and pathologic analysis of radical prostatectomy specimens are crucial to confirm the diagnosis of prostate cancer and evaluate prognostic criteria.
  
  
  METHODS
  A systematic review of the scientific literature was performed in the Medline database (PubMed), using different associations of the following keywords: prostate cancer; prostatectomy; specimen; handling; pathology; tumor staging; Gleason score; surgical margin; prognosis; frozen section; lymph node; biomarkers. A particular search was done on specimen management and characterization of tissue prognostic factors.
  
  
  RESULTS
  Handling of both radical prostatectomy specimen and lymph node dissection is standardized according to international criteria. Although the main histoprognostic factors are still Gleason score, pathologic staging and margin status, these criteria have been refined these last 10 years, allowing to improve the prediction of relapse after surgical treatment.
  
  
  CONCLUSIONS
  The standardization of handling and pathology reporting of radical prostatectomy specimens will be mandatory for treatment uniformization according to risk stratification in prostate cancer and personalization of therapeutic approaches.
authors.affiliation: Service d'anatomie et cytologie pathologique, CHU Bretonneau, 2, boulevard Tonnellé, 37000 Tours, France.
authors.forename: G
authors.initials: G
authors.lastname: Fromont
authors.affiliation: Service d'anatomie et cytologie pathologique, CHU de Fort-de-France, Fort-de-France, Martinique.
authors.forename: V
authors.initials: V
authors.lastname: Molinié
authors.affiliation: Département d'urologie-andrologie-transplantation rénale, CHU Rangueil, 1, avenue Jean-Poulhès, 31059 Toulouse cedex 9, France. Electronic address: soulie.m@chu-toulouse.fr.
authors.forename: M
authors.initials: M
authors.lastname: Soulié
authors.affiliation: Service d'urologie et de transplantation rénale et pancréatique, CHU Mondor, 51, avenue Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Salomon
mesh_terms: D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D017410:Practice Guidelines as Topic; D011379:Prognosis; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*
keywords: Anatomopathologie; Cancer de la prostate; Curage ganglionnaire; Facteurs pronostiques; Lymphadenectomy; Pathology; Prognostic factors; Prostate cancer; Prostatectomie totale; Radical prostatectomy