title: Non-allergic asthma as a CFTR-related disorder.
abstract: CFTR dysfunction can be involved in CBAVD, pancreatitis or bronchiectasis.
  
  
  
  Subjects with cystic fibrosis-like disease, equivocal sweat chloride concentrations and no or one disease-causing CFTR mutation were investigated by intestinal current and/or nasal potential difference measurements.
  
  
  
  A subgroup of female patients who had been diagnosed to suffer from non-allergic asthma showed intermediary chloride concentrations in sweat test, normal chloride secretory responses in the intestine and an abnormal nasal potential difference with Sermet scores in the cystic fibrosis range.
  
  
  
  Non-allergic asthma is a clinical entity that may be associated with CFTR dysfunction of the respiratory epithelium.
authors.affiliation: Clinic for Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany. Electronic address: schulz.angela@mh-hannover.de.
authors.forename: Angela
authors.initials: A
authors.lastname: Schulz
authors.affiliation: Clinic for Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany. Electronic address: tuemmler.burkhard@mh-hannover.de.
authors.forename: Burkhard
authors.initials: B
authors.lastname: Tümmler
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D002648:Child; D002712:Chlorides / Q000032:analysis; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D005260:Female; D005858:Germany; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000503:physiopathology; D008564:Membrane Potentials; D008875:Middle Aged; D009154:Mutation; D009297:Nasal Mucosa / Q000737:chemistry / Q000378:metabolism / Q000503:physiopathology; D013223:Statistics as Topic; D013542:Sweat / Q000737:chemistry / Q000502:physiology
chemical_list: D002712:Chlorides; D019005:Cystic Fibrosis Transmembrane Conductance Regulator
keywords: Asthma; Bronchiectasis; CFTR; Intestinal current measurement; Nasal transepithelial potential difference