title: Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK.
abstract: BACKGROUND
  Gestational diabetes mellitus (GDM) is a disease often manifests in mid to late pregnancy with symptoms including hyperglycemia, insulin resistance and fetal mal-development. The C57BL/KsJ-Lep (db/+) (db/+) mouse is a genetic GDM model that closely mimicked human GDM symptoms. Resveratrol (RV) is a naturally existing compound that has been reported to exhibit beneficial effects in treating type-2 diabetes.
  
  
  METHODS
  In this study, we investigated the effect of RV on the pregnant db/+ GDM mouse model, and the underlying molecular mechanism.
  
  
  RESULTS
  RV greatly improved glucose metabolism, insulin tolerance and reproductive outcome of the pregnant db/+ females. Moreover, we found that RV relieved GDM symptoms through enhancing AMPK activation, which in turn reduced production and activity of glucose-6-phosphatase in both pregnant db/+ females and their offspring.
  
  
  CONCLUSIONS
  Our findings further supported the potential therapeutic effect of RV on not only diabetes, but also alleviating GDM.
authors.affiliation: Department of Obstetrics, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, 250021, Shandong, China.
authors.forename: Liangqi
authors.initials: L
authors.lastname: Yao
authors.affiliation: Department of Gynaecology, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, 250021, Shandong, China.
authors.forename: Jipeng
authors.initials: J
authors.lastname: Wan
authors.affiliation: Department of Obstetrics, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, 250021, Shandong, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.affiliation: Maternal and Child Health Hospital of Shandong Province, Jinan, Shandong, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Obstetrics, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, 250021, Shandong, China.
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Obstetrics, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, 250021, Shandong, China. wangxietong@outlook.com.
authors.forename: Xietong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Obstetrics, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, 250021, Shandong, China. limingjiang@outlook.com.
authors.forename: Mingjiang
authors.initials: M
authors.lastname: Li
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D016640:Diabetes, Gestational / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D007333:Insulin Resistance; D051379:Mice; D011247:Pregnancy; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects*; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D013267:Stilbenes; D000263:Adenylate Kinase; D000077185:Resveratrol