title: Huge Pulmonary Arteriovenous Malformation, Venous Thromboembolism and Anticoagulation Treatment in a Patient with Hereditary Hemorrhagic Telangiectasia.
abstract: Hereditary hemorrhagic telangiectasia (HHT) usually presents in association with pulmonary arteriovenous malformations (PAVMs). In addition, the incidence of venous thromboembolism tends to be increased in these patients. A 74-year-old female with HHT presented with cyanosis and hypoxemia. Contrast-enhanced multislice computed tomography (MSCT) revealed two left PAVMs and one in the right upper lobe. Both left PAVMs were treated with embolotherapy. Follow-up MSCT revealed an incidental pulmonary embolism in the right pulmonary branches. Deep venous thrombosis was confirmed and anticoagulation was initiated. Follow-up MSCT revealed the resolution of thromboembolism. Finally, embolotherapy was performed. This case illustrates the chronic adaptation to hypoxemia and adds further evidence to the relative safety of anticoagulation treatment in these patients.
authors.affiliation: Internal Medicine Department, Italian Hospital of Buenos Aires, Buenos Aires University, Argentina.
authors.forename: Marcelo M
authors.initials: MM
authors.lastname: Serra
authors.forename: Bruno L
authors.initials: BL
authors.lastname: Ferreyro
authors.forename: Oscar
authors.initials: O
authors.lastname: Peralta
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Levy Yeyati
authors.forename: Natalia
authors.initials: N
authors.lastname: Causada Calo
authors.forename: Teresa
authors.initials: T
authors.lastname: Garcia-Botta
authors.forename: Diego
authors.initials: D
authors.lastname: Andresik
authors.forename: Martín
authors.initials: M
authors.lastname: Rabellino
authors.forename: Ricardo
authors.initials: R
authors.lastname: Garcia-Mónaco
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D001165:Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D003490:Cyanosis / Q000209:etiology; D004621:Embolization, Therapeutic / Q000379:methods; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D015994:Incidence; D061330:Multidetector Computed Tomography; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy
chemical_list: D000925:Anticoagulants