title: Human papillomavirus infection in male patients with STI-related symptoms in Hanoi, Vietnam.
abstract: This cross-sectional study investigated the prevalence, genotypes, and risk factors for human papillomavirus (HPV) infection in Hanoi, Vietnam. The study included 192 males (mean age, 32.9 years) with symptoms related to sexually transmitted infections (STI). Urinary, penile, and urethral samples were collected in April and May, 2014. HPV DNA was detected with PCR, performed with modified and/or original GP5(+)/GP6(+) primers. HPV genotypes were determined with a gene array assay. Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) DNA were detected with loop-mediated isothermal amplification. HPV DNA, NG, and CT were detected in 48 (25.0%), 23 (12.0%), and 41 (21.4%) patients, respectively. HPV DNA appeared in penile samples (21.0%, 39/186) more frequently than in urinary (3.1%, 6/191, P < 0.001) and urethral (9.4%, 18/192, P = 0.002) samples. Among patients with HPV, genotype prevalence was: HPV81 (22.9%),  HPV52 (18.8%), HPV18 (16.7%), and HPV16 (6.3%). Multiple-type and high risk-type HPV infections were determined in 33.3% and 64.6%, respectively. Multivariate analysis showed a significant association of HPV infection in urethra with younger sexual debut age. HPV52 was the most prevalent high-risk HPV genotype, whereas HPV16 was less common in the male Vietnamese patients with STI-related symptoms. Younger sexual-debut age was a risk factor for HPV infection in urethra.
authors.affiliation: Department of Viral Infection and International Health, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Hai Ha Long
authors.initials: HH
authors.lastname: Le
authors.affiliation: Department of Viral Infection and International Health, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Xiuqiong
authors.initials: X
authors.lastname: Bi
authors.affiliation: Department of Viral Infection and International Health, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Azumi
authors.initials: A
authors.lastname: Ishizaki
authors.affiliation: Hanoi Medical University, Hanoi, Vietnam.|National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
authors.forename: Hung
authors.initials: H
authors.lastname: Van Le
authors.affiliation: Hanoi Medical University, Hanoi, Vietnam.
authors.forename: Trung Vu
authors.initials: TV
authors.lastname: Nguyen
authors.affiliation: Eiken Chemical Co., Ohtawara, Tochigi, Japan.
authors.forename: Norimitsu
authors.initials: N
authors.lastname: Hosaka
authors.affiliation: Department of Viral Infection and International Health, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ichimura
mesh_terms: D000328:Adult; D000368:Aged; D002690:Chlamydia Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D060085:Coinfection / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005838:Genotype; D006069:Gonorrhea / Q000150:complications / Q000453:epidemiology / Q000382:microbiology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D010413:Penis / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior; D012749:Sexually Transmitted Diseases / Q000453:epidemiology* / Q000821:virology; D014521:Urethra / Q000821:virology; D014526:Urethritis / Q000453:epidemiology / Q000821:virology; D014556:Urine / Q000821:virology; D014744:Vietnam / Q000453:epidemiology; D055815:Young Adult
keywords: HPV; STI; Vietnam; male