title: Association between the CYP1A2 rs762551 Polymorphism and Bladder Cancer Susceptibility: a Meta-Analysis Based on Case-Control Studies.
abstract: BACKGROUND
  Previous studies evaluated associations between the CYP1A2 rs762551 polymorphism and bladder cancer risk. However, the results were inconsistent. We therefore performed a meta-analysis of the published case-control studies to assess in detail the association between CYP1A2 rs762551 polymorphism and bladder cancer risk.
  
  
  METHODS
  PubMed, Embase and Web of Science were searched to identify relevant studies and the pooled odds ratio (OR) and 95 % confidence interval (95%CI) were calculated.
  
  
  RESULTS
  A total of seven articles including 3,013 cases and 2,771 controls were finally included. Overall, a significant association was found between the CYP1A2 rs762551 polymorphism and bladder cancer susceptibility for CC vs AA (OR=0.82, 95% CI=0.69~0.99), but no significant associations were found for the other three models (AC vs AA: OR=0.91, 95% CI=0.81~1.02; the dominant model: OR=0.90, 95% CI=0.80~1.00; the recessive model: OR=0.84, 95% CI =0.72~1.00). In the subgroup analysis by ethnicity, we detected significant associations between the CYP1A2 rs762551 polymorphism and bladder cancer susceptibility for GA vs GG (OR = 0.78, 95% CI =0.64~0.96) and for the recessive model (OR=0.80, 95% CI=0.66~0.96) in Caucasians, but not for Asians.
  
  
  CONCLUSIONS
  The results from the meta-analysis suggested that the CYP1A2 rs762551 polymorphism is a protective factor for bladder cancer, especially in Caucasians.
authors.affiliation: Department of Cardiothoracic Surgery, Shaoxing People's Hospital , Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang Province, China E-mail : chuanliu2005@163.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.forename: Hua-Yong
authors.initials: HY
authors.lastname: Jiang
authors.forename: Li
authors.initials: L
authors.lastname: Wei
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Xu
authors.forename: Ya-Jie
authors.initials: YJ
authors.lastname: Wang
authors.forename: Ya-Di
authors.initials: YD
authors.lastname: Wang
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
mesh_terms: D016022:Case-Control Studies; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2