title: Comparison of amoxicillin + clavulanate with or without intranasal fluticasone for the treatment of uncomplicated acute rhinosinusitis in children.
abstract: OBJECTIVE
  Intranasal corticosteroids (INS) have been proven effective in controlling postnasal drip, decreasing inflammatory response, reducing nasal swelling, and increasing aeration of the sinuses such that INS are recommended as treatment of sinusitis.
  
  
  METHODS
  Fifty children with acute rhinosinusitis, 50 children with acute rhiniosinusitis and allergic rhinitis (AR), and 20 rhiniosinusitis children as control were selected for investigation. Each group had a single-blind treatment of three types: with coamoxiclav only, with coamoxiclav plus INS, and with matched placebo (without antibiotics and INS) for two weeks. Nasal symptoms were then evaluated. The outcome was measured by using major symptom score (MSS) after treatment for 14 days.
  
  
  RESULTS
  Therapeutic effectiveness was 92% in rhinosinusitis patients treated with co-amoxiclav and 84% in those treated with co-amoxiclav plus INS. Among patients with sinusitis combined with AR, therapeutic efficacy was 88% for those treated with co-amoxiclav and 96% for those treated with co-amoxiclav plus INS. Only 30% of the symptoms were reduced in the placebo group.
  
  
  CONCLUSIONS
  There are no statistical differences in the acute sinusitis group treated with co-amoxiclav with or without INS. In the sinusitis with AR group, the efficacy of co-amoxiclav with INS is higher than in children treated with co-amoxiclav alone.
authors.affiliation: Department of Pediatrics, Taipei City Hospital, Renai Branch, Taiwan - gwan1998@gmail.com.
authors.forename: K S
authors.initials: KS
authors.lastname: Wan
authors.forename: W F
authors.initials: WF
authors.lastname: Wu
authors.forename: T C
authors.initials: TC
authors.lastname: Chen
authors.forename: C S
authors.initials: CS
authors.lastname: Wu
authors.forename: C W
authors.initials: CW
authors.lastname: Hung
authors.forename: Y S
authors.initials: YS
authors.lastname: Chang
mesh_terms: D000208:Acute Disease; D000281:Administration, Intranasal; D000293:Adolescent; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage / Q000627:therapeutic use*; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D000068298:Fluticasone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012220:Rhinitis / Q000188:drug therapy*; D065631:Rhinitis, Allergic / Q000188:drug therapy; D016037:Single-Blind Method; D012852:Sinusitis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination; D000068298:Fluticasone