title: γ-PARCEL: Control of Molecular Release Using γ-Rays.
abstract: We previously have developed the photoresponsive tetra-gel and nanoparticles for controlling the function of the encapsulated substance by UV irradiation. However, the penetration ability of the UV is not high enough. Here, we developed a radiation-responsive tetra-gel and nanoparticle based on γ-ray-responsive X-shaped polyethylene glycol (PEG) linker with a disulfide bond. The nanoparticle could retain small molecules and biomacromolecules. γ-Rays were used as a trigger signal because of their higher penetrating ability. This allowed a spatiotemporal release and control of the encapsulated substances from the nanoparticle in the deeper region, which is impossible by using light exposure (ultraviolet, visible, and near-infrared).
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Murayama
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Jo
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Arai
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Nishikido
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Rumiana
authors.initials: R
authors.lastname: Bakalova
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Taiga
authors.initials: T
authors.lastname: Yamaya
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Saga
authors.affiliation: Graduate School of Pharmaceutical Sciences and GPLLI Program, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kato
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Ichio
authors.initials: I
authors.lastname: Aoki
mesh_terms: D000818:Animals; D004220:Disulfides / Q000737:chemistry; D005720:Gamma Rays; D005782:Gels / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013552:Swine
chemical_list: D004220:Disulfides; D005782:Gels; D011506:Proteins; D011092:Polyethylene Glycols