title: Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.
abstract: Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Volkan
authors.initials: V
authors.lastname: Yesilyurt
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Webber
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Appel
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Colin
authors.initials: C
authors.lastname: Godwin
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.|Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.|Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Anderson
mesh_terms: D001897:Boronic Acids / Q000737:chemistry; D015195:Drug Design; D005947:Glucose / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007267:Injections; D055595:Mechanical Phenomena; D011092:Polyethylene Glycols / Q000737:chemistry*; D014783:Viscosity
chemical_list: D001897:Boronic Acids; D020100:Hydrogels; D011092:Polyethylene Glycols; D005947:Glucose; C010686:benzeneboronic acid
keywords: boronic acids; dynamic covalent bonds; hydrogels; rheology; self-healing