title: Efficacy of 2% mepivacaine and 2% lignocaine in the surgical extraction of mesioangular angulated bilaterally impacted third molars: A double-blind, randomized, clinical trial.
abstract: OBJECTIVE
  The purpose of this prospective, randomized, double-blind study was to compare the anesthetic efficacy of 2% mepivacaine and 2% lidocaine (both with 1:80,000 epinephrine) for inferior alveolar nerve block in mesioangular bilaterally impacted third molar extraction.
  
  
  METHODS
  Forty patients with mesioangular bilaterally impacted third molars were taken for the study; either 2% mepivacaine or 2% lidocaine is given in a double-blind manner. Surgery started 5 min after solution deposition. Success was defined as no or mild discomfort (visual analog scale [VAS] recordings) during the surgical procedure.
  
  
  RESULTS
  The mean time for onset period 4.2 min and 4.6 min (P = 0.018). The mean duration anesthesia 177.17 min 166.71 min (P = 0.085). No significant difference between the scores of pain reported by the patients by VAS and venovenous bypass treated with mepivacaine and lidocaine (P = 0.000). Slight increased postoperative analgesics required for mepivacaine group (4.000 tablets) and lidocaine group (4.170 tablets) (P = 0.335). The sharp increase of pulse rate with respect to both the solutions at 5 min after postinjection of local anesthetics. However, there was no statically significant difference in systolic and diastolic blood (P = 0.681) and (P = 0.270).
  
  
  CONCLUSIONS
  Lidocaine and mepivacaine with the same vasoconstrictor have similar action and both solutions are effective in surgical procedures. There were also no significant differences between them in relation to the intensity of postoperative pain.
authors.affiliation: Department of Periodontics, Lenora Institute of Dental Sciences, Rajanagaram, Rajamundry, Andhra Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Barath
authors.affiliation: Department of Periodontics, Lenora Institute of Dental Sciences, Rajanagaram, Rajamundry, Andhra Pradesh, India.
authors.forename: V S S
authors.initials: VS
authors.lastname: Triveni
authors.affiliation: Department of Periodontics, Lenora Institute of Dental Sciences, Rajanagaram, Rajamundry, Andhra Pradesh, India.
authors.forename: G V Naga
authors.initials: GV
authors.lastname: Sai Sujai
authors.affiliation: Department of Periodontics, Lenora Institute of Dental Sciences, Rajanagaram, Rajamundry, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Harikishan
keywords: Mepivacaine; lignocaine; local anesthetics