title: Selective Halogen-Lithium Exchange of 1,2-Dihaloarenes for Successive [2+4] Cycloadditions of Arynes and Isobenzofurans.
abstract: Successive [2+4] cycloadditions of arynes and isobenzofurans by site-selective halogen-lithium exchange of 1,2-dihaloarenes were developed, allowing the rapid construction of polycyclic compounds which serve as a useful synthetic intermediates for the preparation of various polyacene derivatives.
authors.affiliation: Department of Applied Chemistry for Environment, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337, Japan. shoheie816@gmail.com.
authors.forename: Shohei
authors.initials: S
authors.lastname: Eda
authors.affiliation: Department of Applied Chemistry for Environment, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337, Japan. thamura@kwansei.ac.jp.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hamura
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction; D007454:Iodides / Q000737:chemistry; D008094:Lithium / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis*
chemical_list: D001572:Benzofurans; D001965:Bromides; D007454:Iodides; D011083:Polycyclic Compounds; D008094:Lithium; C054509:iodobromine; C105430:benzofuran
keywords: 1,2-dihaloarenes; [2+4] cycloaddition; aryne; halogen-lithium exchange; isobenzofuran; polyacene