title: Methylenetetrahydrofolate reductase gene polymorphism in endometrial cancer: A systematic review and meta-analysis.
abstract: OBJECTIVE
  We conducted a meta-analysis of case-controlled prospective or retrospective studies to assess the effect of MTHFR polymorphisms on the risk of developing endometrial cancer.
  
  
  METHODS
  PubMed, Cochrane, EMBASE, and ISI Web of Knowledge were searched (up to March 2014) for prospective or retrospective case-controlled studies that investigated the association of three MTHFR polymorphisms (rs180113 [C677T], rs1801131 [A1289C], and rs2274976 [G1793A]) with endometrial cancer.
  
  
  RESULTS
  The patient population included subjects from three separate countries: China, Spain, and the USA. Only one study reported quantitative findings for MTHFR G1793A and, consequently, this polymorphism was not evaluated in our analysis. There were no significant associations of any MTHFR C677T or MTHFR A1298C alleles or genotypes with endometrial cancer (all p > 0.300).
  
  
  CONCLUSIONS
  This meta-analysis does not support the association of endometrial cancer with two common MTHFR polymorphisms from this patient population.
authors.affiliation: Department of Laboratory Medicine, Hangzhou First People's Hospital, Hangzhou, China. Electronic address: wangxj0525@126.com.
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, Hangzhou First People's Hospital, Hangzhou, China.
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Xu
authors.affiliation: Department of Laboratory Medicine, Hangzhou First People's Hospital, Hangzhou, China.
authors.forename: Yue-Ming
authors.initials: YM
authors.lastname: Chen
authors.affiliation: School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Laboratory Medicine, Hangzhou First People's Hospital, Hangzhou, China.
authors.forename: Qiao-Feng
authors.initials: QF
authors.lastname: Tu
authors.affiliation: Department of Obstetrics/Gynaecology and Genetics, Hangzhou First People's Hospital, Hangzhou, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Mei
mesh_terms: D000483:Alleles; D016889:Endometrial Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D014943:Global Health; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics* / Q000378:metabolism; D009017:Morbidity / Q000639:trends; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: MTHFR; endometrial cancer; methylenetetrahydrofolate reductase; polymorphisms; risk