title: Comparative usefulness of inflammatory markers to indicate bacterial infection-analyzed according to blood culture results and related clinical factors.
abstract: To assess relationships of inflammatory markers and 2 related clinical factors with blood culture results, we retrospectively investigated inpatients' blood culture and blood chemistry findings that were recorded from January to December 2014 using electronic medical records and analyzed the data of 852 subjects (426 culture-positive and 426 culture-negative). Results suggested that the risk of positive blood culture statistically increased as inflammatory marker levels and the number of related factors increased. Concerning the effectiveness of inflammatory markers, when the outcome definition was also changed for C-reactive protein (CRP), the odds ratio had a similar value, whereas when the outcome definition of blood culture positivity was used for procalcitonin (PCT), the greatest effectiveness of that was detected. Therefore, the current results suggest that PCT is more useful than CRP as an auxiliary indication of bacterial infection.
authors.affiliation: Department of Clinical Laboratory, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan. Electronic address: n-h@gaia.eonet.ne.jp.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nishikawa
authors.affiliation: Department of Infectious Diseases, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
authors.forename: Michinori
authors.initials: M
authors.lastname: Shirano
authors.affiliation: Department of Infectious Diseases, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Kasamatsu
authors.affiliation: Department of Infectious Diseases, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Morimura
authors.affiliation: Department of Infectious Diseases, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
authors.forename: Ko
authors.initials: K
authors.lastname: Iida
authors.affiliation: Department of Infectious Diseases, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kishi
authors.affiliation: Department of Infectious Diseases, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Goto
authors.affiliation: Department of Clinical Laboratory, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Okamoto
authors.affiliation: Department of Clinical Laboratory, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan; Department of Pediatric Cardiology, Osaka City General Hospital, 2-13-22, Miyakojimahondoori, Miyakojima-ku, Osaka-shi, Osaka, 534-0021, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Ehara
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide
keywords: Bacterial infection; C-reactive protein; Organ failure; Procalcitonin; Systemic inflammatory response syndrome