title: Fertility biomarkers to estimate metabolic risks in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  We sought to evaluate the relationship between the polycystic ovary syndrome (PCOS)-defining characteristics and the risk of developing metabolic complications in women presenting with complaints of infertility and/or menstrual irregularities and subsequently diagnosed with PCOS.
  
  
  METHODS
  This was a cross-sectional study. Women presenting with complaints of infertility and/or irregular menses and diagnosed with PCOS by the Rotterdam criteria, underwent endocrine, metabolic, and ultrasound assessment in the early follicular phase. Reproductive and metabolic parameters were included in regression analysis models with the PCOS-defining characteristics; ROC curves were calculated for the significant predictors.
  
  
  RESULTS
  Three hundred and seventy-four women with PCOS were included in our study. Oligo-anovulation, menstrual irregularities, and hirsutism were not predictive of any of the variables. Ovarian volume, follicle count, and biochemical hyperandrogenism were predictors for hormonal, metabolic, and endometrial complications. The relationships were independent of age and body mass index. ROC curves identified lower cut-off values of the PCOS-defining characteristics to predict patients' risks of hyperinsulinemia, dyslipidemia, and glucose intolerance.
  
  
  CONCLUSIONS
  Adverse metabolic effects of PCOS are already present in women at the time they present complaining of infertility and/or irregular menses. Hyperandrogenism and ultrasound can assist in predicting the patients' concomitant metabolic abnormalities and can aid physicians in tailoring counseling for effective preventive strategies.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Tennessee Health Science Center, Rout Center, 853 Jefferson Ave, Rm E102, Memphis, TN, 38163, USA. ldetti@uthsc.edu.
authors.forename: Laura
authors.initials: L
authors.lastname: Detti
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Tennessee Health Science Center, Rout Center, 853 Jefferson Ave, Rm E102, Memphis, TN, 38163, USA.
authors.forename: Heather E
authors.initials: HE
authors.lastname: Jeffries-Boyd
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Tennessee Health Science Center, Rout Center, 853 Jefferson Ave, Rm E102, Memphis, TN, 38163, USA.
authors.forename: Lucy J
authors.initials: LJ
authors.lastname: Williams
authors.affiliation: Department of Obstetrics and Gynecology, Georgia Regents University, Augusta, GA, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Diamond
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Tennessee Health Science Center, Rout Center, 853 Jefferson Ave, Rm E102, Memphis, TN, 38163, USA.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Uhlmann
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000378:metabolism; D016015:Logistic Models; D008659:Metabolic Diseases / Q000150:complications / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D015415:Biomarkers
keywords: Cross-sectional; Glucose intolerance; Hyperandrogenism; Hyperinsulinemia; Metabolic; PCOS