title: Effect of Regular Exercise on Inflammation Induced by Drug-resistant Staphylococcus aureus 3089 in ICR mice.
abstract: Obesity is often associated with irregular dietary habits and reduced physical activity. Regular exercise induces a metabolic response that includes increased expression of various cytokines, signaling proteins and hormones, and reduced adipocyte size. In this study, mice performed a swimming exercise for 10 min/day, 5 days/week for 3 weeks. We then investigated the effect of this exercise regimen on inflammation induced by infection with drug-resistant Staphylococcus aureus strain 3089 (DRSA). In humans, DRSA causes dermatitis and pneumonitis. Similarly, DRSA induced inflammatory pneumonitis in both no-exercise (No-EX) and swim-trained (SW-EX) ICR mice. Regular exercise increased levels of the pro-inflammatory cytokines TNF-α and IL-1β and nitric oxide in both serum and whole lung tissue in SW-EX, as compared to No-EX control mice. Moreover, levels of the antimicrobial peptide cathelicidin were significantly increased in visceral adipose tissue and whole lung tissue in the SW-EX group, and this was accompanied by a reduction in the size of visceral adipocytes. In addition, levels of the inflammation marker peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) were not increased in the lung tissue of SW-EX mice. These findings suggest that in these model mice, regular exercise strengthens immune system responses, potentially preventing or mitigating infectious disease.
authors.affiliation: Research Center for Proteinaceous Materials (RCPM), Chosun University, Gwangju, Korea.
authors.forename: Jong-Kook
authors.initials: JK
authors.lastname: Lee
authors.affiliation: Department of Physics, Alexandru I. Cuza University, Iasi, Romania.
authors.forename: Tudor
authors.initials: T
authors.lastname: Luchian
authors.affiliation: Department of Biotechnology &BK21-Plus Research Team for Bioactive Control Technology, Chosun University, Gwangju, Republic of Korea.
authors.forename: Yoonkyung
authors.initials: Y
authors.lastname: Park
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood; D024881:Drug Resistance, Bacterial; D007249:Inflammation / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D010805:Physical Conditioning, Animal; D013211:Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity*
chemical_list: D016207:Cytokines