title: Dihydroagarofuranoid Sesquiterpenes as Acetylcholinesterase Inhibitors from Celastraceae Plants: Maytenus disticha and Euonymus japonicus.
abstract: Natural cholinesterase inhibitors have been found in many biological sources. Nine compounds with agarofuran (epoxyeudesmane) skeletons were isolated from seeds and aerial parts of Maytenus disticha and Euonymus japonicus. The identification and structural elucidation of compounds were based on spectroscopic data analyses. All compounds had inhibitory acetylcholinesterase (AChE) activity. These natural compounds, which possessed mixed or uncompetitive mechanisms of inhibitory activity against AChE, may be considered as models for the design and development of new naturally occurring drugs for management strategies for neurodegenerative diseases. This is the first report of these chemical structures for seeds of M. disticha.
authors.affiliation: Laboratorio de Sı́ntesis y Biotransformación de Productos Naturales, Facultad de Ciencias, Universidad del Bı́o-Bı́o , Avenida Andrés Bello s/n, Casilla 447, CP 3780000, Chillán, Chile.
authors.forename: Julio
authors.initials: J
authors.lastname: Alarcón
authors.affiliation: Laboratorio de Sı́ntesis y Biotransformación de Productos Naturales, Facultad de Ciencias, Universidad del Bı́o-Bı́o , Avenida Andrés Bello s/n, Casilla 447, CP 3780000, Chillán, Chile.
authors.forename: Carlos L
authors.initials: CL
authors.lastname: Cespedes
authors.affiliation: Laboratorio de Sı́ntesis y Biotransformación de Productos Naturales, Facultad de Ciencias, Universidad del Bı́o-Bı́o , Avenida Andrés Bello s/n, Casilla 447, CP 3780000, Chillán, Chile.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Muñoz
authors.affiliation: Laboratorio de Sı́ntesis y Biotransformación de Productos Naturales, Facultad de Ciencias, Universidad del Bı́o-Bı́o , Avenida Andrés Bello s/n, Casilla 447, CP 3780000, Chillán, Chile.
authors.forename: Cristian
authors.initials: C
authors.lastname: Balbontin
authors.affiliation: Instituto de Quı́mica, Universidad de Talca , Talca, Chile.
authors.forename: Francisco
authors.initials: F
authors.lastname: Valdes
authors.affiliation: Instituto de Quı́mica, Universidad de Talca , Talca, Chile.
authors.forename: Margarita
authors.initials: M
authors.lastname: Gutierrez
authors.affiliation: Instituto de Quı́mica, Universidad de Talca , Talca, Chile.
authors.forename: Luis
authors.initials: L
authors.lastname: Astudillo
authors.affiliation: Department of Plant Biology, Herbarium, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
authors.forename: David S
authors.initials: DS
authors.lastname: Seigler
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D029756:Euonymus / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D012717:Sesquiterpenes; D000110:Acetylcholinesterase
keywords: Celastraceae; Eudesmanolides; Euonimus japonicus; Maytenus disticha; acetylcholinesterase; dihydroagarofurans