title: Genotypic anomaly in Ebola virus strains circulating in Magazine Wharf area, Freetown, Sierra Leone, 2015.
abstract: The Magazine Wharf area, Freetown, Sierra Leone was a focus of ongoing Ebola virus transmission from late June 2015. Viral genomes linked to this area contain a series of 13 T to C substitutions in a 150 base pair intergenic region downstream of viral protein 40 open reading frame, similar to the Ebolavirus/H.sapiens-wt/SLE/2014/Makona-J0169 strain (J0169) detected in the same town in November 2014. This suggests that recently circulating viruses from Freetown descend from a J0169-like virus.
authors.affiliation: Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Saskia L
authors.initials: SL
authors.lastname: Smits
authors.forename: Suzan D
authors.initials: SD
authors.lastname: Pas
authors.forename: Chantal B
authors.initials: CB
authors.lastname: Reusken
authors.forename: Bart L
authors.initials: BL
authors.lastname: Haagmans
authors.forename: Peirro
authors.initials: P
authors.lastname: Pertile
authors.forename: Corrado
authors.initials: C
authors.lastname: Cancedda
authors.forename: Kerry
authors.initials: K
authors.lastname: Dierberg
authors.forename: Isata
authors.initials: I
authors.lastname: Wurie
authors.forename: Abdul
authors.initials: A
authors.lastname: Kamara
authors.forename: David
authors.initials: D
authors.lastname: Kargbo
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Caddy
authors.forename: Armando
authors.initials: A
authors.lastname: Arias
authors.forename: Lucy
authors.initials: L
authors.lastname: Thorne
authors.forename: Jia
authors.initials: J
authors.lastname: Lu
authors.forename: Umaru
authors.initials: U
authors.lastname: Jah
authors.forename: Ian
authors.initials: I
authors.lastname: Goodfellow
authors.forename: Marion P
authors.initials: MP
authors.lastname: Koopmans
mesh_terms: D004196:Disease Outbreaks; D029043:Ebolavirus / Q000235:genetics* / Q000302:isolation & purification; D016679:Genome, Viral; D005838:Genotype; D019142:Hemorrhagic Fever, Ebola / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012807:Sierra Leone
keywords: Ebola virus; surveillance; viral infections