title: Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008-2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry.
abstract: OBJECTIVE
  To examine the effect of recipient body mass index (BMI) on IVF outcomes in fresh donor oocyte cycles.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  A total of 22,317 donor oocyte cycles from the 2008-2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry were stratified into cohorts based on World Health Organization BMI guidelines. Cycles reporting normal recipient BMI (18.5-24.9) were used as the reference group.
  
  
  METHODS
  None.
  
  
  METHODS
  Implantation rate, clinical pregnancy rate (PR), pregnancy loss rate, live birth rate.
  
  
  RESULTS
  Success rates and adjusted odds ratios with 95% confidence intervals for all pregnancy outcomes were most favorable in cohorts of recipients with low and normal BMI, but progressively worsened as BMI increased.
  
  
  CONCLUSIONS
  Success rates in recipient cycles are highest in those with low and normal BMI. Furthermore, there is a progressive and statistically significant worsening of outcomes in groups with higher BMI with respect to clinical pregnancy and live birth rate.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
authors.forename: Meredith P
authors.initials: MP
authors.lastname: Provost
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
authors.forename: Kelly S
authors.initials: KS
authors.lastname: Acharya
authors.affiliation: Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina.
authors.forename: Chaitanya R
authors.initials: CR
authors.lastname: Acharya
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Yeh
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
authors.forename: Ryan G
authors.initials: RG
authors.lastname: Steward
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Eaton
authors.affiliation: University Hospitals Fertility Center, Beachwood, Ohio.
authors.forename: James M
authors.initials: JM
authors.lastname: Goldfarb
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina. Electronic address: muashersj@gmail.com.
authors.forename: Suheil J
authors.initials: SJ
authors.lastname: Muasher
mesh_terms: D015992:Body Mass Index; D010064:Embryo Implantation; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D016015:Logistic Models; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D016017:Odds Ratio; D018587:Oocyte Donation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D018873:Pregnancy Rate; D012042:Registries; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
keywords: BMI; IVF; Obesity; donor; recipient; success rates