title: [The assessed value of 64 slice spiral CT perfusion imaging in laryngeal squamous cell carcinoma after chemotherapy and radiotherapy].
abstract: OBJECTIVE
  To study the assessed value of 64 slice spiral CT perfusion imaging (CTPI) in laryngeal squamous cell carcinoma after chemotherapy and radiotherapy.
  
  
  METHODS
  Forty five patients diagnosed with local advanced laryngeal squamous cell carcinoma were selected. Conventional CT and CTPI were performed before treatment and at the time of radiation dose up to 40 Gy. Blood flow, blood volume, mean transit time and surface permeability were measured at the same time. According to the decrease of tumor volume in final examination, patients were divided into sensitive group and insensitive group. The tumor perfusion indexes were compared between groups.
  
  
  RESULTS
  Blood flow, blood volume, surface permeability after 40Gy treatment were lower than before treatment in both sensitive group and the insensitive group ascended(P<0. 05). The AUC of ROC of blood flow, blood volume, mean transit time and surface permeability were 0. 804, 0. 843, 0. 852 and 0. 826. The sensitivity, specificity and accuracy of blood flow was 89. 7%, 86.8% and 90. 9%. There were 100. 0%, 91. 4% and 93. 7% in blood volume; 100. 0%, 67. 7% and 88. 3% in mean transit time; 91. 2%, 69. 4% and 90. 6% in surface permeability(P<0. 01).
  
  
  CONCLUSIONS
  Sixty-four slice spiral CT perfusion imaging is able to assess tumor status of laryngeal squamous cell carcinoma after chemotherapy and radiotherapy effectively.
authors.forename: Maosheng
authors.initials: M
authors.lastname: Yan
authors.forename: Xianming
authors.initials: X
authors.lastname: Li
authors.forename: Hang
authors.initials: H
authors.lastname: Yin
authors.forename: Dong
authors.initials: D
authors.lastname: Wu
authors.forename: Dong
authors.initials: D
authors.lastname: Yang
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D055420:Perfusion Imaging; D012680:Sensitivity and Specificity; D000077195:Squamous Cell Carcinoma of Head and Neck; D036542:Tomography, Spiral Computed; D047368:Tumor Burden