title: The correct renal function evaluation in patients with thyroid dysfunction.
abstract: Thyroid dysfunction induces several renal derangements involving all nephron portions. Furthermore, dysthyroidism is a recognized risk factor associated with the development of chronic kidney disease. Current data, in fact, demonstrate that either subclinical or overt thyroid disease is associated with significant changes in creatinine, estimated glomerular filtration rate, measured glomerular filtration rate and Cystatin C. Herein, we systematically reviewed several relevant studies aiming at the identification of the most sensitive and specific parameter for the correct renal function evaluation in patients with thyroid dysfunction, that are usually treated as outpatients. Our systematic review indicates that estimated glomerular filtration rate, preferably with CKD-EPI equation, appears to be the most reliable and wieldy renal function parameter. Instead, Cystatin C should be better used in the grading of thyroid dysfunction severity.
authors.affiliation: Nephrology and Dialysis Unit, 'Magna Graecia' University, 88100, Catanzaro, CZ, Italy. adelina_simeoni@yahoo.it.|University Campus 'Magna Graecia', Viale Europa-Loc. Germaneto, 88100, Catanzaro, Italy. adelina_simeoni@yahoo.it.
authors.forename: Mariadelina
authors.initials: M
authors.lastname: Simeoni
authors.affiliation: Nephrology and Dialysis Unit, 'Magna Graecia' University, 88100, Catanzaro, CZ, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Cerantonio
authors.affiliation: Endocrinology Unit, 'Magna Graecia' University, 88100, Catanzaro, CZ, Italy.
authors.forename: Ida
authors.initials: I
authors.lastname: Pastore
authors.affiliation: Endocrinology Unit, 'Magna Graecia' University, 88100, Catanzaro, CZ, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Liguori
authors.affiliation: Clinical Pathology Unit, 'Magna Graecia' University, 88100, Catanzaro, CZ, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Greco
authors.affiliation: Clinical Pathology Unit, 'Magna Graecia' University, 88100, Catanzaro, CZ, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Foti
authors.affiliation: Clinical Pathology Unit, 'Magna Graecia' University, 88100, Catanzaro, CZ, Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Gulletta
authors.affiliation: Clinical Pathology Unit, 'Magna Graecia' University, 88100, Catanzaro, CZ, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Brunetti
authors.affiliation: Nephrology and Dialysis Unit, 'Magna Graecia' University, 88100, Catanzaro, CZ, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Fuiano
mesh_terms: D005069:Evaluation Studies as Topic; D005919:Glomerular Filtration Rate; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000453:epidemiology; D013959:Thyroid Diseases / Q000503:physiopathology*
keywords: Creatinine; Cystatin C; Renal physiology; Thyroid diseases; eGFR