title: Biotinylated Cubosomes: A Versatile Tool for Active Targeting and Codelivery of Paclitaxel and a Fluorescein-Based Lipid Dye.
abstract: The functionalization of cubosomes with biotin is reported here as an alternative method for the preparation of drug delivery systems capable of active targeting specific receptors that are (over)expressed by cancer cells. We describe the design, synthesis, assembly, and characterization of these novel cubosome nanoparticles by small-angle X-ray scattering (SAXS) and dynamic laser light scattering (DLS) and show their application to human adenocarcinoma cell line HeLa. These cubosomes are stabilized and functionalized with a novel, designed biotin-based block copolymer and are able to simultaneously transport paclitaxel, a potent anticancer drug, and a hydrophobic fluorescent dye in the active targeting of cancer cells. Such biotinylated cubosomes are potentially applicable in diagnosis, drug delivery, and monitoring of the therapeutic response for active targeting versus cancer cells.
authors.affiliation: Department of Chemistry, University of Zürich , Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
authors.forename: Simone
authors.initials: S
authors.lastname: Aleandri
authors.affiliation: Department of Chemistry, University of Zürich , Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
authors.forename: Davide
authors.initials: D
authors.lastname: Bandera
authors.affiliation: Department of Health Science & Technology, ETH Zurich , Schmelzbergstrasse 9, LFO, E23, 8092 Zürich, Switzerland.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Mezzenga
authors.affiliation: Department of Chemistry, University of Zürich , Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
authors.forename: Ehud M
authors.initials: EM
authors.lastname: Landau
mesh_terms: D001692:Biological Transport; D001710:Biotin / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D019793:Fluorescein / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D050866:Liquid Crystals / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D005456:Fluorescent Dyes; D008055:Lipids; D001710:Biotin; D017239:Paclitaxel; D019793:Fluorescein