title: Prognostic Role of Tumor-Infiltrating Lymphocytes in Lung Cancer: a Meta-Analysis.
abstract: OBJECTIVE
  The role of Tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with lung cancer is still controversial. We performed a meta-analysis to evaluate the prognostic role of TILs in lung cancer.
  
  
  METHODS
  Studies were recruited by searching PubMed, Embase and the Cochrane Library and assessed by further quality evaluation. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to investigate the association between TIL subsets and lung cancer patients' outcome.
  
  
  RESULTS
  A total of 29 articles including 8,600 patients were enrolled into the meta-analysis. Our results indicated that high level of CD8+ cells infiltration in tumor stroma (TS) or tumor nest (TN) was associated with better OS in lung cancer patients (HR = 0.76, 95% CI 0.62-0.93, P = 0.006; HR = 0.80, 95% CI 0.67-0.96; P = 0.018, respectively). Similar results could be also observed in CD3+ T cells infiltration. High CD4+ T lymphocytes infiltration in TS was explicitly accompanied by better OS (HR = 0.65, 95% CI 0.46-0.91; P = 0.013), rather than in TN. In contrast, high density of FOXP3+ T cells infiltration in TS showed a poor PFS (HR = 2.67, 95% CI, 1.74-4.08, P < 0.001).
  
  
  CONCLUSIONS
  This meta-analysis clarified that high level of CD8+ and CD3+ T cells infiltration in TS or TN, and high CD4+ T lymphocytes infiltration in TS showed better OS in lung cancer patients, whereas high density of FOXP3+ T cells infiltration in TS could be recognized as a negative prognostic factor.
authors.forename: Yiting
authors.initials: Y
authors.lastname: Geng
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Shao
authors.forename: Wenting
authors.initials: W
authors.lastname: He
authors.forename: Wenwei
authors.initials: W
authors.lastname: Hu
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Changping
authors.initials: C
authors.lastname: Wu
authors.forename: Jingting
authors.initials: J
authors.lastname: Jiang
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D016208:Databases, Factual; D018572:Disease-Free Survival; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D016017:Odds Ratio; D011379:Prognosis
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors