title: Years of life lost due to metastatic melanoma in 12 countries.
abstract: BACKGROUND
  Regionally or distantly metastatic melanoma (stages IIIB/C and IV) place a high burden on society. To quantify this burden, this study estimated years of life lost (YLL) per patient for adults with metastatic melanoma in 12 countries in 2014.
  
  
  METHODS
  General population growth and life expectancy were estimated from the Organization for Economic Co-operation and Development data and life tables for each country. Incidence of melanoma and mortality rates for the disease were based on GLOBOCAN and US registry data. The prevalence of metastatic melanoma was calculated using mortality rates and survival data from patients with melanoma. YLL per patient was estimated by the difference between the disease-free life expectancy and the life expectancy with metastatic melanoma.
  
  
  RESULTS
  YLL per patient were as follows: Australia, men = 19.9 years, women = 22.7 years; Brazil, 16.3, 19.8; Canada, 19.4, 22.3; France, 18.8, 23.1; Germany, 18.3, 20.8; Italy, 19.3, 22.7; Mexico, 17.2, 19.0; the Netherlands, 18.5, 21.5; Spain, 19.2, 23.1; Sweden 19.4, 22.0; the UK, 18.7, 21.2; and the US, 17.9, 20.6.
  
  
  CONCLUSIONS
  The burden of metastatic melanoma as measured by YLL is substantial in all 12 countries; although there is variation across countries and between men and women.
authors.affiliation: a a PRMA Consulting Ltd , Fleet, Hampshire , UK.
authors.forename: Aminata
authors.initials: A
authors.lastname: Thiam
authors.affiliation: b b Amgen, Global Health Economics , Thousand Oaks , CA , USA.
authors.forename: Zhongyun
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: a a PRMA Consulting Ltd , Fleet, Hampshire , UK.
authors.forename: Casey
authors.initials: C
authors.lastname: Quinn
authors.affiliation: b b Amgen, Global Health Economics , Thousand Oaks , CA , USA.
authors.forename: Beth
authors.initials: B
authors.lastname: Barber
mesh_terms: D005260:Female; D006801:Humans; D015994:Incidence; D008017:Life Expectancy; D015993:Life Tables; D008297:Male; D008545:Melanoma / Q000401:mortality* / Q000473:pathology; D009367:Neoplasm Staging; D015995:Prevalence; D012042:Registries
keywords: Disease burden; Life expectancy; Metastatic melanoma; Mortality; YLL