title: [IN VIVO EFFECT OF RED WINE UNDILUTED, DILUTED (75%) AND ALCOHOL-FREE ON THE GENOTOXIC DAMAGE INDUCED BY POTENTIAL CARCINOGENIC METALS: CHROMIUM [VI]].
abstract: BACKGROUND
  the carcinogenesis may be initiated and promoted by the oxidative DNA damage. The compounds of chrome (Cr [VI]) cause oxidative stress (EOx) and are recognized as carcinogens in humans. In this sense, it is proposed that drinks with a high antioxidative potential, such as red wine, may have protective or modulatory effects on the oxidative DNA damage.
  
  
  OBJECTIVE
  to study the effects of the administration in vivo of undiluted, diluted (75%) and alcohol-free red wine on the genotoxic damage induced by carcinogenic metals (Cr [VI]), by evaluating the micronucleus (MN) in polychromatic erythrocytes (EPC) in mice (CD-1).
  
  
  METHODS
  it was randomly organized the follow groups: (i) control, (ii) undiluted, diluted and alcohol-free red wine (free access), (iii) CrO3 (20 mg/kg by intraperitoneal route) and (iv) CrO3-red wine. The evaluations were made in blood samples obtained from the caudal vein, in which it was identified the MN and EPC before, during and after treatments.
  
  
  CONCLUSIONS
  the red wine (diluted and alcohol-free) was capable of decreasing the averages of MN induced by CrO3, demonstrating its modular capacity in vivo in the oxidative DNA damage caused by EOx-induced carcinogens. The administration of only undiluted red wine presented toxic effects.
  
  
  CONCLUSIONS
  our results raises expectations on the use of substances like the red wine for the protection or modulation of genotoxic damage, encouraging its application in the carcinogenic and mutagenic processes.
authors.affiliation: Unidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Facultad de Estudios Superiores "Zaragoza", Universidad Nacional Autónoma de México (UNAM). México.. carmen.garcia@unam.mx.
authors.forename: María del Carmen
authors.initials: Mdel C
authors.lastname: García Rodríguez
authors.affiliation: Unidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Facultad de Estudios Superiores "Zaragoza", Universidad Nacional Autónoma de México (UNAM). México.. carmen.garcia@unam.mx.
authors.forename: Rodrigo Aníbal
authors.initials: RA
authors.lastname: Mateos Nava
authors.affiliation: Unidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Facultad de Estudios Superiores "Zaragoza", Universidad Nacional Autónoma de México (UNAM). México.. carmen.garcia@unam.mx.
authors.forename: Mario
authors.initials: M
authors.lastname: Altamirano Lozano
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002273:Carcinogens / Q000037:antagonists & inhibitors / Q000633:toxicity*; D017608:Chromium Compounds / Q000633:toxicity*; D004249:DNA Damage; D005260:Female; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D014920:Wine
chemical_list: D016587:Antimutagenic Agents; D002273:Carcinogens; D017608:Chromium Compounds; D009153:Mutagens; C053245:chromium dioxide