title: Overcoming drug resistance for tuberculosis.
abstract: Despite enormous progress, tuberculosis (TB) is still a major global health problem. Poor patients' adherence to the current treatment leads to the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) strains. While increased numbers of MDR-TB cases can be ascribed to difficulties in treating TB-HIV coinfected patients, many studies demonstrated that the emergence of drug-resistant TB is clearly linked to misdiagnosis and mismanagement of drug-susceptible TB. Therefore, rapid detection and proper treatment are needed globally to both cure TB patients and prevent wide spreading of the disease. This paper provides a survey of the major strategies that have been explored for overcoming drug resistance in TB.
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, piazzale Aldo Moro 5, I-00185 Roma, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Poce
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, piazzale Aldo Moro 5, I-00185 Roma, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Biava
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003955:Diagnostic Tests, Routine / Q000379:methods / Q000592:standards; D024881:Drug Resistance, Bacterial; D004358:Drug Therapy / Q000379:methods / Q000592:standards; D006801:Humans; D055118:Medication Adherence; D009161:Mycobacterium / Q000187:drug effects*; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents
keywords: MDR-TB; XDR-TB; drug resistance; tuberculosis