title: Lipid A as a Drug Target and Therapeutic Molecule.
abstract: In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.
authors.affiliation: Laboratory of Biochemistry, College of Pharmacy, Catholic University of Daegu, Gyeongbuk 38430, Republic of Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Joo
keywords: Adjuvant; Antibacterial; Drug target; Endotoxin; Lipid A