title: Primary renal neuroblastoma with metastasis and matrix metalloproteinase-14 expression.
abstract: We herein report the rare case of a 4-year-5-month-old boy who presented with primary renal neuroblastoma. The patient developed repeated lung and liver metastatic recurrences, but, following a combination of chemotherapy, radiation therapy and aggressive surgical resection, the patient is now in remission. To investigate the pathogenesis of lung metastasis, immunohistochemistry was performed for matrix metalloproteinase-9 and -14 (MMP-9 and MMP-14), molecular markers of invasion, metastasis and angiogenesis in neuroblastoma. In the present case, MMP-9 expression was not observed, but MMP-14 expression was detected in the primary lesion and was more highly expressed in the metastatic lesion compared with the primary one. Given the MMP-14 staining in other cases, expression of MMP-14 may be associated with the aggressiveness of the tumor. This suggests that selected clones with high MMP-14 expression in the primary tumor might metastasize and form MMP-14-rich lesions.
authors.affiliation: Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Zenitani
authors.affiliation: Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Uehara
authors.affiliation: Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Miyashita
authors.affiliation: Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Hashii
authors.affiliation: Department of Pediatric Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
authors.forename: Takaharu
authors.initials: T
authors.lastname: Oue
authors.affiliation: Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Hiroomi
authors.initials: H
authors.lastname: Okuyama
mesh_terms: D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D009392:Nephrectomy; D009447:Neuroblastoma / Q000378:metabolism / Q000473:pathology*
chemical_list: C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14
keywords: lung metastasis; matrix metalloproteinase-14; matrix metalloproteinase-9; renal neuroblastoma