title: Dynamic disconnection of the supplementary motor area after processing of dismissive biographic narratives.
abstract: BACKGROUND
  To understand the interplay between affective social information processing and its influence on mental states we investigated changes in functional connectivity (FC) patterns after audio exposure to emotional biographic narratives.
  
  
  METHODS
  While lying in the 7T MR scanner, 23 male participants listened to narratives of early childhood experiences of three persons, each having either a secure, dismissing, or preoccupied attachment representation. Directly after having listened to each of the prototypical narratives, participants underwent a 10-minute resting-state fMRI scan. To study changes in FC patterns between experimental conditions, three post-task conditions were compared to a baseline condition. Specific local alterations, as well as differences in connectivity patterns between distributed brain regions, were quantified using Network-based statistics (NBS) and graph metrics.
  
  
  RESULTS
  Using NBS, a nine-region subnetwork showing reduced FC after having listened to the dismissing narrative was identified. Of this subnetwork, only the left Supplementary Motor Area (SMA) exhibited a decrease in the nodal graph metrics degree and strength exclusively after listening to the dismissing narrative. No other region showed post-task changes in nodal metrics. A post hoc analysis of dynamic characteristics of FC of the left SMA showed a significant decrease in the dismissing condition when compared with the other conditions in the first three minutes of the scan, but faded away in the two subsequent intervals the differences.
  
  
  CONCLUSIONS
  Nodal metrics and NBS converge on reduced connectivity measures exclusively in left SMA in the dismissing condition, which may specifically reflect ongoing network changes underlying prolonged emotional reactivity to attachment-related processing.
authors.affiliation: Leibniz Institute for Neurobiology Magdeburg Germany ; Clinical Affective Neuroimaging Laboratory Magdeburg Germany.
authors.forename: Viola
authors.initials: V
authors.lastname: Borchardt
authors.affiliation: Clinical Affective Neuroimaging Laboratory Magdeburg Germany ; Department of Psychiatry and Psychotherapy Otto von Guericke University Magdeburg Germany.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Krause
authors.affiliation: Clinical Affective Neuroimaging Laboratory Magdeburg Germany ; Department of Neurology Otto von Guericke University Magdeburg Germany.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: University of Groningen University Medical Center Groningen Neuroimaging Center Groningen the Netherlands.
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: van Tol
authors.affiliation: Clinical Affective Neuroimaging Laboratory Magdeburg Germany ; Department of Neurology Otto von Guericke University Magdeburg Germany.
authors.forename: Liliana Ramona
authors.initials: LR
authors.lastname: Demenescu
authors.affiliation: Institute of Psychology University of Innsbruck Innsbruck Austria.
authors.forename: Anna
authors.initials: A
authors.lastname: Buchheim
authors.affiliation: Leibniz Institute for Neurobiology Magdeburg Germany ; Department of Psychiatry and Psychotherapy Otto von Guericke University Magdeburg Germany ; Institute for Cognitive Neurology and Dementia Research (IKND) Magdeburg Germany ; German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany.
authors.forename: Coraline D
authors.initials: CD
authors.lastname: Metzger
authors.affiliation: Department of Neurology Otto von Guericke University Magdeburg Germany ; Neurocybernetics and Rehabilitation Department for Neurology and Stereotactic Neurosurgery Otto von Guericke University Magdeburg Germany.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Sweeney-Reed
authors.affiliation: Anna Freud Centre London UK ; Wellcome Trust Centre for Neuroimaging University College of London London UK.
authors.forename: Tobias
authors.initials: T
authors.lastname: Nolte
authors.affiliation: Leibniz Institute for Neurobiology Magdeburg Germany ; Clinical Affective Neuroimaging Laboratory Magdeburg Germany.
authors.forename: Anton R
authors.initials: AR
authors.lastname: Lord
authors.affiliation: Leibniz Institute for Neurobiology Magdeburg Germany ; Clinical Affective Neuroimaging Laboratory Magdeburg Germany ; Department of Psychiatry and Psychotherapy Otto von Guericke University Magdeburg Germany ; Center for Behavioral Brain Sciences (CBBS) Magdeburg Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Walter
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000465:Algorithms; D001931:Brain Mapping / Q000379:methods; D003071:Cognition / Q000502:physiology; D063132:Connectome / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*
keywords: Acoustic stimulation; adult attachment representation; cognitive affective neuroscience; fMRI; functional connectivity; graph theory; human social interactions; resting‐state