title: Electrochemical behavior of palmatine and its sensitive determination based on an electrochemically reduced L-methionine functionalized graphene oxide modified electrode.
abstract: A new and sensitive voltammetric sensor for palmatine, based on an electrochemically reduced L-methionine functionalized graphene oxide modified glassy carbon electrode (L-Met-ERGO/GCE), is reported. The electrochemical characteristics of palmatine at the proposed sensor were studied systematically and some dynamic parameters were calculated for the first time. A reasonable reaction mechanism for palmatine on the L-Met-ERGO/GCE electrode was proposed and discussed, and this could be a reference for the pharmacological action of palmatine in clinical study. Under optimized conditions, the peak current had a linear relationship with palmatine concentration in the range of 1 × 10(-7) to 5 × 10(-5) mol L(-1) with a detection limit of 6 × 10(-8) mol L(-1). Additionally, the proposed method was also used to detect palmatine in human urine samples, medicinal tablets and the Chinese herb Fibraurea recisa Pierre with satisfactory results.
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, PR China. yebx@zzu.edu.cn.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Qiao
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Baoxian
authors.initials: B
authors.lastname: Ye
authors.forename: Gaiping
authors.initials: G
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D001600:Berberine Alkaloids / Q000032:analysis* / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods*; D055664:Electrochemical Techniques; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D057230:Limit of Detection; D008715:Methionine / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D001600:Berberine Alkaloids; D006108:Graphite; D008715:Methionine; C005413:palmatine