title: Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.
abstract: Rapid activation of memory CD4(+) T helper 2 (TH2) cells during allergic inflammation requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate lymphoid (ILC2) cells have a crucial role in memory TH2 cell responses, with targeted depletion of ILC2 cells profoundly impairing TH2 cell localization to the lungs and skin of sensitized mice after allergen re-challenge. ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell-attracting chemokine CCL17 by IRF4(+)CD11b(+)CD103(-) dendritic cells (DCs). Consequently, the sentinel function of DCs is contingent on ILC2 cells for the generation of an efficient memory TH2 cell response. These results elucidate a key innate mechanism in the regulation of the immune memory response to allergens.
authors.affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, Cambridgeshire, UK.
authors.forename: Timotheus Y F
authors.initials: TY
authors.lastname: Halim
authors.affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, Cambridgeshire, UK.
authors.forename: You Yi
authors.initials: YY
authors.lastname: Hwang
authors.affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, Cambridgeshire, UK.
authors.forename: Seth T
authors.initials: ST
authors.lastname: Scanlon
authors.affiliation: Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.
authors.forename: Habib
authors.initials: H
authors.lastname: Zaghouani
authors.affiliation: Department of Molecular Immunology, Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, Germany.
authors.forename: Natalio
authors.initials: N
authors.lastname: Garbi
authors.affiliation: Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.|National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland.|Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.
authors.forename: Padraic G
authors.initials: PG
authors.lastname: Fallon
authors.affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, Cambridgeshire, UK.
authors.forename: Andrew N J
authors.initials: AN
authors.lastname: McKenzie
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D004195:Disease Models, Animal; D005434:Flow Cytometry; D006967:Hypersensitivity / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D020411:Oligonucleotide Array Sequence Analysis; D018418:Th2 Cells / Q000276:immunology*