title: Comparative study of quality of life of adult survivors of childhood acute lymphocytic leukemia and Wilms' tumor.
abstract: OBJECTIVE
  To analyze and compare the health-related quality of life of adult survivors of acute lymphocytic leukemia and Wilms' tumor amongst themselves and in relation to healthy participants.
  
  
  METHODS
  Ninety participants aged above 18 years were selected and divided into three groups, each comprising 30 individuals. The Control Group was composed of physically healthy subjects, with no cancer history; and there were two experimental groups: those diagnosed as acute lymphocytic leukemia, and those as Wilms' Tumor. Quality of life was assessed over the telephone, using the Medical Outcomes Study 36-Item Short Form Health Survey.
  
  
  RESULTS
  Male survivors presented with better results as compared to female survivors and controls in the Vitality domain, for acute lymphocytic leukemia (p=0.042) and Wilms' tumor (p=0.013). For acute lymphocytic leukemia survivors, in Social aspects (p=0.031), Mental health (p=0.041), and Emotional aspects (p=0.040), the latter also for survivors of Wilms' tumor (p=0.040). The best results related to the Functional capacity domain were recorded for the experimental group that had a late diagnosis of acute lymphocytic leukemia. There were significant differences between groups except for the Social and Emotional domains for self-perceived health, with positive responses that characterized their health as good, very good, and excellent.
  
  
  CONCLUSIONS
  Survivors of acute lymphocytic leukemia showed no evidence of relevant impairment of health-related quality of life. The Medical Outcomes Study 36-Item Short Form Health Survey (via telephone) can be a resource to access and evaluate survivors.
authors.affiliation: Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Clélia Marta Casellato de
authors.initials: CM
authors.lastname: Souza
authors.affiliation: Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Lilian Maria
authors.initials: LM
authors.lastname: Cristofani
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Ana Lucia Beltrati
authors.initials: AL
authors.lastname: Cornacchioni
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Vicente
authors.initials: V
authors.lastname: Odone Filho
authors.affiliation: Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Kuczynski
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000704:Analysis of Variance; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006305:Health Status Indicators; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000523:psychology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000523:psychology; D011788:Quality of Life; D057566:Self Report; D012737:Sex Factors; D012959:Socioeconomic Factors; D015996:Survival Rate; D017741:Survivors / Q000523:psychology*; D013689:Telephone; D009396:Wilms Tumor / Q000453:epidemiology* / Q000523:psychology; D055815:Young Adult