title: Sex differences between APPswePS1dE9 mice in A-beta accumulation and pancreatic islet function during the development of Alzheimer's disease.
abstract: The pathogenesis of Alzheimer's disease (AD), a type of neurodegenerative disease characterized by learning and memory impairment, is often associated with pathological features, such as amyloid-beta (Aβ) accumulation and insulin resistance. The transgenic mouse, APPswePS1dE9 (APP/PS1), is one of the most commonly used animal models in pathogenesis studies of AD. The purpose of this study is to investigate the sex differences between APP/PS1 mice in the pathogenesis of AD. The impairment of glucose and insulin tolerance was found to develop earlier in male APP/PS1 mice than in females. Plasma insulin levels were significantly decreased in male APP/PS1 mice, while total cholesterol levels in male APP/PS1 mice were higher than those in females. Triglyceride levels in male mice in both the wild-type (WT) and APP/PS1 groups were higher than in their female littermates. Soluble and insoluble Aβ levels in female APP/PS1 mouse brains were higher than those in males. And the learning and memorizing abilities of female APP/PS1 mice were poorer than those of males. Our results concluded that there were sex differences in Aβ formation, pancreatic islet function and insulin sensitivity between male and female APP/PS1 mice during the pathogenesis of AD.
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Feng
authors.affiliation: West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhao
authors.affiliation: West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Fu
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yangnan
authors.initials: Y
authors.lastname: Ding
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Binghuo
authors.initials: B
authors.lastname: Wu
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yanju
authors.initials: Y
authors.lastname: Gong
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Guizhi
authors.initials: G
authors.lastname: Yang
authors.affiliation: West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China zhouxue7239@163.com ygzxky@163.com.
authors.forename: Xue
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008297:Male; D008568:Memory; D051379:Mice; D008822:Mice, Transgenic; D012727:Sex Characteristics; D065853:Spatial Learning
chemical_list: D016229:Amyloid beta-Peptides; D007328:Insulin; D008055:Lipids
keywords: APPswePS1dE9 mouse; Alzheimer’s disease; sex difference