title: The preventive effect of vaccine prophylaxis on severe respiratory syncytial virus infection: A meta-analysis.
abstract: Respiratory syncytial virus (RSV) is the key underlying cause of acute lower respiratory tract infection in infants; however, no licensed vaccine against RSV infection is currently available. This study was undertaken to assess the preventive effect of vaccine on RSV infection. In this metaanalysis, 1,792 published randomized clinical trials of RSV vaccines from Jan 1973 to Sep 2015 were examined. Among thirteen studies that met the inclusion criteria, eleven studies estimated the impact of RSV vaccines and four studies estimated the effect of adjuvants. The odds ratios (ORs) were 0.31 (95% CI, 0.15-0.67) and 0.62 (95% CI, 0.29-1.34), respectively. We found that RSV subunit vaccines can significantly reduce the incidence of RSV infection and that whether vaccination with adjuvant therapy was an effective strategy still remained to be studied. This analysis of the preventive effect of vaccines on RSV infection has direct applications for the prevention of RSV infections.
authors.affiliation: Department of Microbiology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, China.
authors.forename: Tongna
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Department of Pediatrics, the People's Hospital of Lu'an City, Lu'an, 237005, China.
authors.forename: Chuanlong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Microbiology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Microbiology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, China.|Department of Pathology and Cell Biology, Columbia University, New York, 10032, USA.
authors.forename: Jingxian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Microbiology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Department of Microbiology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Lyu
authors.affiliation: Department of Microbiology, School of Basic Medicine, Anhui Medical University, Hefei, 230032, China. shenghaihuang1@gmail.com.|School of Life Science, Anhui Medical University, Hefei, 230032, China. shenghaihuang1@gmail.com.
authors.forename: Shenghai
authors.initials: S
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D016017:Odds Ratio; D016032:Randomized Controlled Trials as Topic; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000517:prevention & control*; D022261:Respiratory Syncytial Virus Vaccines / Q000008:administration & dosage*; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology; D055815:Young Adult
chemical_list: D022261:Respiratory Syncytial Virus Vaccines
keywords: meta-analysis; respiratory syncytial virus (RSV); vaccine prophylaxis