title: Antibody Repertoires in Fish.
abstract: As in mammals, cartilaginous and teleost fishes possess adaptive immune systems based on antigen recognition by immunoglobulins (Ig), T cell receptors (TCR), and major histocompatibility complex molecules (MHC) I and MHC II molecules. Also it is well established that fish B cells and mammalian B cells share many similarities, including Ig gene rearrangements, and production of membrane Ig and secreted Ig forms. This chapter provides an overview of the IgH and IgL chains in cartilaginous and bony fish, including their gene organizations, expression, diversity of their isotypes, and development of the primary repertoire. Furthermore, when possible, we have included summaries of key studies on immune mechanisms such as allelic exclusion, somatic hypermutation, affinity maturation, class switching, and mucosal immune responses.
authors.affiliation: Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS, 39216-4505, USA. ebengten@umc.edu.
authors.forename: Eva
authors.initials: E
authors.lastname: Bengtén
authors.affiliation: Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS, 39216-4505, USA. mwilson@umc.edu.
authors.forename: Melanie
authors.initials: M
authors.lastname: Wilson
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics / Q000276:immunology; D000818:Animals; D000916:Antibody Diversity / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D005075:Biological Evolution; D005399:Fishes / Q000145:classification / Q000235:genetics / Q000276:immunology*; D014644:Genetic Variation / Q000235:genetics / Q000276:immunology; D007143:Immunoglobulin Heavy Chains / Q000235:genetics / Q000276:immunology*; D007147:Immunoglobulin Light Chains / Q000235:genetics / Q000276:immunology*
chemical_list: D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains
keywords: Antibody isotypes; Diversity; Elasmobranchs; Gene organization; Immunoglobulin; Primary repertoire; Teleosts