title: Association analysis of APOA5 rs662799 and rs3135506 polymorphisms with obesity in Moroccan patients.
abstract: The aim of the present study is to explore the association between the APOA5 polymorphisms and haplotypes with obesity in Moroccan patients. The study was performed in 459 subjects, Obese (n=164) and non-obese (n=295). All subjects were genotyped for the APOA5 -1131T>C (rs662799) and c.56C>G (rs3135506) polymorphisms. The contribution of APOA5 polymorphisms and haplotypes in the increased risk of obesity were explored using logistic regression analyses. The -1131T>C and c.56C>G polymorphisms were significantly associated with obesity. Both polymorphisms were strongly associated with increased BMI. Analysis of constructed haplotypes showed a significant association between CG haplotype and susceptibility to obesity (OR [95%CI]=3.09 [1.93-4.97]; P<0.001). These results support a potential role for APOA5 common variants and related haplotypes as risk factors for obesity.
authors.affiliation: Institut Pasteur, laboratoire de génétique moléculaire humaine, Casablanca, Morocco; Équipe d'anthropogénétique et biotechnologies, faculté des sciences, université Chouaïb Doukkali, El Jadida, Morocco.
authors.forename: F
authors.initials: F
authors.lastname: Lakbakbi El Yaagoubi
authors.affiliation: Institut Pasteur, laboratoire de génétique moléculaire humaine, Casablanca, Morocco.
authors.forename: H
authors.initials: H
authors.lastname: Charoute
authors.affiliation: Institut Pasteur, laboratoire de génétique moléculaire humaine, Casablanca, Morocco.
authors.forename: A
authors.initials: A
authors.lastname: Bakhchane
authors.affiliation: Institut Pasteur, laboratoire de génétique moléculaire humaine, Casablanca, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Ajjemami
authors.affiliation: Institut Pasteur, laboratoire de génétique moléculaire humaine, Casablanca, Morocco.
authors.forename: H
authors.initials: H
authors.lastname: Benrahma
authors.affiliation: Institut Pasteur, laboratoire de génétique moléculaire humaine, Casablanca, Morocco.
authors.forename: A
authors.initials: A
authors.lastname: Errouagui
authors.affiliation: Équipe d'anthropogénétique et biotechnologies, faculté des sciences, université Chouaïb Doukkali, El Jadida, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Kandil
authors.affiliation: Institut Pasteur, laboratoire de génétique moléculaire humaine, Casablanca, Morocco.
authors.forename: H
authors.initials: H
authors.lastname: Rouba
authors.affiliation: Institut Pasteur, laboratoire de génétique moléculaire humaine, Casablanca, Morocco. Electronic address: hamid.barakat@pasteur.ma.
authors.forename: A
authors.initials: A
authors.lastname: Barakat
mesh_terms: D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A
keywords: APOA5; Haplotypes; Maroc; Morocco; Obesity; Obésité; Polymorphismes; Polymorphisms