title: Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease.
abstract: The effect of bromocriptine, a dopamine agonist, administered in the form of bromocriptine alginate nanocomposite (BANC) was studied on Parkinson's disease (PD) model flies. The synthesized BANC was subject to characterization and, at a final concentration of 0.5, 1.0 and 1.5 µM, was mixed in diet. The PD flies were allowed to feed on it for 24 days. A significant dose-dependent delay in the loss of climbing activity and activity pattern was observed in PD flies exposed to 0.5, 1.0 and 1.5 µM BANC. The PD flies exposed to BANC also showed a significant reduction in lipid peroxidation and glutathione-S-transferase activity, and an increase in glutathione content. However, no gross morphological changes were observed in the brains of PD flies compared with controls. The results suggest that BANC is effective in reducing the PD symptoms in these transgenic flies.
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India yasir_hasansiddique@rediffmail.com.
authors.forename: Yasir Hasan
authors.initials: YH
authors.lastname: Siddique
authors.affiliation: Centre of Excellence in Materials Sciences (Nanomaterials), Department of Applied Physics, Z. H. College of Engineering & Technology, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
authors.forename: Wasi
authors.initials: W
authors.lastname: Khan
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
authors.forename: Ambreen
authors.initials: A
authors.lastname: Fatima
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
authors.forename: Smita
authors.initials: S
authors.lastname: Jyoti
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
authors.forename: Saba
authors.initials: S
authors.lastname: Khanam
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
authors.forename: Falaq
authors.initials: F
authors.lastname: Naz
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
authors.lastname: Rahul
authors.affiliation: Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
authors.forename: Fahad
authors.initials: F
authors.lastname: Ali
authors.affiliation: Centre of Excellence in Materials Sciences (Nanomaterials), Department of Applied Physics, Z. H. College of Engineering & Technology, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
authors.forename: Braj Raj
authors.initials: BR
authors.lastname: Singh
authors.affiliation: Centre of Excellence in Materials Sciences (Nanomaterials), Department of Applied Physics, Z. H. College of Engineering & Technology, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
authors.forename: Alim Hussain
authors.initials: AH
authors.lastname: Naqvi
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D030801:Animals, Genetically Modified; D001921:Brain / Q000502:physiology; D001971:Bromocriptine / Q000737:chemistry*; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005978:Glutathione / Q000737:chemistry; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D053761:Nanocomposites / Q000737:chemistry*; D010300:Parkinson Disease / Q000235:genetics* / Q000628:therapy; D010539:Permeability; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000464:Alginates; D001971:Bromocriptine; D005982:Glutathione Transferase; D005978:Glutathione
keywords: Bromocriptine; Nanocomposite; Parkinson's disease