title: mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment.
abstract: Metabolic reprogramming is a central hallmark of cancer, enabling tumor cells to obtain the macromolecular precursors and energy needed for rapid tumor growth. Understanding how oncogenes coordinate altered signaling with metabolic reprogramming and how cancer cells harness cellular metabolism and its metabolites for their survival may yield new insights into tumor pathogenesis. Here, we review the recently identified central regulatory role for mTORC2, a downstream effector of many cancer-causing mutations, in metabolic reprogramming and cancer drug resistance in glioblastoma. We further consider the emerging concept that mTORC2 may connect genetics with environmental alterations in brain cancer.
authors.affiliation: Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Masui
authors.affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA.
authors.forename: Webster K
authors.initials: WK
authors.lastname: Cavenee
authors.affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Mischel
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm / Q000235:genetics / Q000502:physiology; D005909:Glioblastoma / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D000076222:Mechanistic Target of Rapamycin Complex 1; D000076225:Mechanistic Target of Rapamycin Complex 2; D046912:Multiprotein Complexes / Q000235:genetics* / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D000076225:Mechanistic Target of Rapamycin Complex 2; D058570:TOR Serine-Threonine Kinases
keywords: drug resistance; glioblastoma; mTORC2; metabolic reprogramming; nutrient