title: Peroxisomes Get Loud: A Redox Antidote to Hearing Loss.
abstract: Pejvakin (PJVK), a protein originally identified in Persian families with sensorineural hearing loss, regulates peroxisomal dynamics and the antioxidant defense triggered by noise exposure in hair cells and auditory neurons of the inner ear. These findings bring peroxisomes to the forefront of noise-induced hearing loss research.
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: Mardones
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile; FONDAP Center for Geroscience, Brain Health and Metabolism, University of Chile, Santiago, Chile; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA 02115, USA. Electronic address: chetz@hsph.harvard.edu.
authors.forename: Claudio
authors.initials: C
authors.lastname: Hetz
mesh_terms: D000818:Animals; D006317:Hearing Loss, Noise-Induced / Q000378:metabolism*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D020675:Peroxisomes / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D000094524:Gasdermins
chemical_list: D009419:Nerve Tissue Proteins; D011506:Proteins; C519847:PJVK protein, human; D000094524:Gasdermins; C000605138:pejvakin protein, mouse