title: Novel potential for the management of Alzheimer disease.
abstract: Pathologic characteristics of Alzheimer disease (AD) are β-amyloid (Aβ) plaques, neurofibrillary tangles (NFT) and neurodegeneration. Currently, there is no cure for AD. Cilostazol, a selective inhibitor of type 3 phosphodiesterase, is likely to be a promising agent for AD. In the brain of the experimental animals it significantly reduced the Aβ amyloid plaques. Initial clinical reports on the effect of Cilostazol in AD patients are promising. In mice, stem cells favourably influence the pathogenetic process critical in AD, by reducing deposits of Aβ plaques. Clinical trials of the drug, called Betablock, are already underway in Britain. Successful management and resolution of AD in man will still require further intensive research (Fig. 4, Ref. 11).
authors.forename: E
authors.initials: E
authors.lastname: Ginter
authors.forename: V
authors.initials: V
authors.lastname: Simko
authors.forename: D
authors.initials: D
authors.lastname: Weinrebova
authors.forename: Z
authors.initials: Z
authors.lastname: Ladecka
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D000818:Animals; D019468:Disease Management; D014943:Global Health; D006801:Humans; D009017:Morbidity
keywords: Alzheimer disease; Cilostazol; stem cells.; β-amyloid plaques