title: All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care through the Global Alliance for Genomics and Health.
abstract: The recent explosion of genetic and clinical data generated from tumor genome analysis presents an unparalleled opportunity to enhance our understanding of cancer, but this opportunity is compromised by the reluctance of many in the scientific community to share datasets and the lack of interoperability between different data platforms. The Global Alliance for Genomics and Health is addressing these barriers and challenges through a cooperative framework that encourages "team science" and responsible data sharing, complemented by the development of a series of application program interfaces that link different data platforms, thus breaking down traditional silos and liberating the data to enable new discoveries and ultimately benefit patients.
authors.affiliation: Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom. mark.lawler@qub.ac.uk.
authors.forename: Mark
authors.initials: M
authors.lastname: Lawler
authors.affiliation: University Health Network, Toronto, Canada.
authors.forename: Lillian L
authors.initials: LL
authors.lastname: Siu
authors.affiliation: Harvard Medical School, Boston, Massachusetts.
authors.forename: Heidi L
authors.initials: HL
authors.lastname: Rehm
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Washington, DC.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.affiliation: Harvard Medical School, Boston, Massachusetts.
authors.forename: Gil
authors.initials: G
authors.lastname: Alterovitz
authors.affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Burn
authors.affiliation: Cancer Core Europe and Institute Gustave Roussy Cancer Campus, Grand Paris, Villejuif, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Calvo
authors.affiliation: European Organisation for the Research and Treatment of Cancer, Brussels, Belgium.
authors.forename: Denis
authors.initials: D
authors.lastname: Lacombe
authors.affiliation: National Cancer Centre Singapore, Singapore.
authors.forename: Bin Tean
authors.initials: BT
authors.lastname: Teh
authors.affiliation: Murdoch Children's Research Institute, Melbourne, Australia.
authors.forename: Kathryn N
authors.initials: KN
authors.lastname: North
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Charles L
authors.initials: CL
authors.lastname: Sawyers
mesh_terms: D003299:Cooperative Behavior; D030541:Databases, Genetic; D055808:Drug Discovery / Q000379:methods; D023281:Genomics / Q000379:methods; D014943:Global Health; D006801:Humans; D033181:Information Dissemination; D008495:Medical Oncology; D057285:Precision Medicine / Q000379:methods; D012106:Research