title: SeqSIMLA2_exact: simulate multiple disease sites in large pedigrees with given disease status for diseases with low prevalence.
abstract: It is difficult for current simulation tools to simulate sequence data in a pre-specified pedigree structure and pre-specified affection status. Previously, we developed a flexible tool, SeqSIMLA2, for simulating sequence data in either unrelated case-control or family samples with different disease and quantitative trait models. Here we extended the tool to efficiently simulate sequences with multiple disease sites in large pedigrees with a given disease status for each pedigree member, assuming that the disease prevalence is low.
  
  
  METHODS
  SeqSIMLA2_exact is implemented with C++ and is available at http://seqsimla.sourceforge.net.
authors.affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
authors.forename: Po-Ju
authors.initials: PJ
authors.lastname: Yao
authors.affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
authors.forename: Ren-Hua
authors.initials: RH
authors.lastname: Chung
mesh_terms: D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D004194:Disease / Q000235:genetics*; D056726:Genetic Association Studies; D005828:Genetics, Population; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D015995:Prevalence; D019655:Quantitative Trait, Heritable; D012984:Software