title: ATAD2 is overexpressed in gastric cancer and serves as an independent poor prognostic biomarker.
abstract: OBJECTIVE
  ATPase family, AAA domain containing 2 (ATAD2) has been found overexpressed in various cancer types and correlated with malignant status and poor prognosis. However, little is known about the clinical significance of ATAD2 in gastric cancer patients. The aim of this study was to explore the clinical and prognostic significance of ATAD2 in gastric cancer.
  
  
  METHODS
  The mRNA and protein levels expression of ATAD2 were detected in clinical tissue samples by qRT-PCR and immunohistochemistry, respectively. We examined the ATAD2 protein expression by immunohistochemistry. Furthermore, we analyzed the association between ATAD2 expression and clinicopathological features including prognosis in 166 gastric cancer samples.
  
  
  RESULTS
  In our results, ATAD2 mRNA and protein were highly expressed in gastric cancer samples. ATAD2 overexpression was correlated with advanced clinical stage, tumor depth, lymph node metastasis, and distant metastasis. According to the survival analysis, ATAD2 protein overexpression was a poor independent prognostic factor for gastric cancer patients.
  
  
  CONCLUSIONS
  In summary, ATAD2 could serve as a prognostic biomarker for gastric cancer patients.
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, No.16766 Jingshi Road, Jinan, 250014, China.
authors.forename: M- J
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, No.16766 Jingshi Road, Jinan, 250014, China.
authors.forename: C- Z
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, No.16766 Jingshi Road, Jinan, 250014, China.
authors.forename: W- J
authors.initials: W
authors.lastname: Du
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, No.16766 Jingshi Road, Jinan, 250014, China.
authors.forename: X- Z
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Shandong University, No.16766 Jingshi Road, Jinan, 250014, China. chenziping1966@126.com.
authors.forename: Z- P
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology*; D000251:Adenosine Triphosphatases / Q000032:analysis / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D004268:DNA-Binding Proteins / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000251:Adenosine Triphosphatases; C544857:ATAD2 protein, human; D000074183:ATPases Associated with Diverse Cellular Activities
keywords: ATAD2; Biomarker; Gastric cancer; Prognosis