title: Modulation of C-reactive protein and plasma omega-6 fatty acid levels by phospholipase A2 gene polymorphisms following a 6-week supplementation with fish oil.
abstract: This clinical trial investigated the impact of a six-week supplementation with fish oil and single nucleotide polymorphisms (SNPs) in PLA2G4A and PLA2G6 genes on total omega-6 fatty acid (n-6 FA) levels in plasma phospholipids (PL) and plasma C-reactive protein (CRP) levels in 191 subjects. Interaction effects between SNPs and supplementation modulated total n-6 FAs and CRP levels in both men and women. Associations between SNPs and total n-6 FA levels and between SNPs and CRP levels were identified in men, independently of supplementation. Supplementation decreased total n-6 FAs without affecting plasma CRP levels. Changes in CRP levels correlated positively with changes in total n-6 FAs in men (r=0.25 p=0.01), but not in women. In conclusion, total n-6 FA levels in plasma PL and plasma CRP levels are modulated by SNPs within PLA2G4A and PLA2G6 genes alone or in combination with fish oil supplementation.
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd, Quebec, Qc, Canada G1V 0A6.
authors.forename: B L
authors.initials: BL
authors.lastname: Tremblay
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd, Quebec, Qc, Canada G1V 0A6; CHU de Québec Research Center - Endocrinology and Nephrology, 2705 Laurier Blvd, Quebec, Qc, Canada G1V 4G2.
authors.forename: I
authors.initials: I
authors.lastname: Rudkowska
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd, Quebec, Qc, Canada G1V 0A6.
authors.forename: P
authors.initials: P
authors.lastname: Couture
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd, Quebec, Qc, Canada G1V 0A6.
authors.forename: S
authors.initials: S
authors.lastname: Lemieux
authors.affiliation: CHU de Québec Research Center - Endocrinology and Nephrology, 2705 Laurier Blvd, Quebec, Qc, Canada G1V 4G2.
authors.forename: P
authors.initials: P
authors.lastname: Julien
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd, Quebec, Qc, Canada G1V 0A6; CHU de Québec Research Center - Endocrinology and Nephrology, 2705 Laurier Blvd, Quebec, Qc, Canada G1V 4G2. Electronic address: marie-claude.vohl@fsaa.ulaval.ca.
authors.forename: M C
authors.initials: MC
authors.lastname: Vohl
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D019587:Dietary Supplements; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage / Q000032:analysis / Q000037:antagonists & inhibitors / Q000097:blood*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage* / Q000378:metabolism; D056726:Genetic Association Studies; D054513:Group IV Phospholipases A2 / Q000235:genetics* / Q000378:metabolism; D054522:Group VI Phospholipases A2 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D054647:Nutrigenomics / Q000379:methods; D050177:Overweight / Q000097:blood / Q000235:genetics / Q000378:metabolism; D010743:Phospholipids / Q000097:blood / Q000737:chemistry; D020641:Polymorphism, Single Nucleotide; D011792:Quebec; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D043371:Fatty Acids, Omega-6; D005395:Fish Oils; D010743:Phospholipids; D002097:C-Reactive Protein; D054513:Group IV Phospholipases A2; D054522:Group VI Phospholipases A2; C516389:PLA2G4A protein, human; C516475:PLA2G6 protein, human
keywords: C-reactive protein; Gene-diet interaction; Inflammation; Omega-3 fatty acid; Omega-6 fatty acid; Phospholipase A2