title: Advances in high-density lipoprotein physiology: surprises, overturns, and promises.
abstract: Emerging evidence strongly supports that changes in the HDL metabolic pathway, which result in changes in HDL proteome and function, appear to have a causative impact on a number of metabolic disorders. Here, we provide a critical review of the most recent and novel findings correlating HDL properties and functionality with various pathophysiological processes and disease states, such as obesity, type 2 diabetes mellitus, nonalcoholic fatty liver disease, inflammation and sepsis, bone and obstructive pulmonary diseases, and brain disorders.
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Caterina
authors.initials: C
authors.lastname: Constantinou
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Eleni A
authors.initials: EA
authors.lastname: Karavia
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Eva
authors.initials: E
authors.lastname: Xepapadaki
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Peristera-Ioanna
authors.initials: PI
authors.lastname: Petropoulou
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Papakosta
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Marilena
authors.initials: M
authors.lastname: Karavyraki
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Zvintzou
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Theodoropoulos
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Serafoula
authors.initials: S
authors.lastname: Filou
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Hatziri
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Kalogeropoulou
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Panayiotakopoulos
authors.affiliation: Pharmacology Department, University of Patras Medical School, Rio Achaias, Greece kkypreos@med.upatras.gr.
authors.forename: Kyriakos E
authors.initials: KE
authors.lastname: Kypreos
mesh_terms: D001842:Bone and Bones / Q000502:physiology; D018149:Glucose Intolerance / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000502:physiology; D008075:Lipoproteins, HDL / Q000097:blood / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008659:Metabolic Diseases / Q000097:blood*; D009765:Obesity / Q000378:metabolism; D018805:Sepsis / Q000378:metabolism
chemical_list: D008075:Lipoproteins, HDL
keywords: HDL; bone; brain; disease; inflammation; obesity; obstructive pulmonary; type 2 diabetes mellitus