title: Editor's Choice - Treatment of Aortic Prosthesis Infections by Graft Removal and In Situ Replacement with Autologous Femoral Veins and Fascial Strengthening.
abstract: BACKGROUND
  Aortic prosthetic graft infection (AGI) is a major challenge in vascular surgery. Eradicating the infection requires prosthetic material removal, debridement, and lower limb revascularization. For the past 15 years, we have used femoral veins for aorto-iliac reconstruction and tensor fascia lata to strengthen the upper anastomosis.
  
  
  OBJECTIVE
  The purpose of this single institution retrospective study is to present results regarding in situ replacement of infected aortic grafts with autologous femoral veins (FVs).
  
  
  METHODS
  From October 2000 to March 2013, patients treated for AGI with graft removal and autologous FV reconstruction at Helsinki University Hospital were included. Primary outcome measures were 30 day mortality, long-term treatment related mortality, and re-infection rate. Secondary outcome measures were long-term all cause mortality and event free survival (graft rupture, re-intervention, major amputation).
  
  
  RESULTS
  During a 13 year period 55 patients (42 male, 13 female) were operated on using a venous neo-aorto-iliac system for AGI. The mean follow up was 32 months (1-157 months). The 30 day mortality rate was 9% (5) and overall treatment related mortality 18% (10). All cause mortality during follow up was 22 (40%) and overall Kaplan-Meier survival was 90.7% at 30 days, 81.5% at 1 year, and 59.3% at 5 years. Graft rupture occurred in three (5%) cases, two of which were caused by graft re-infection (4%). Four patients required major amputation, one of them on arrival and three (5%) during the post-operative period. Nine (16%) patients needed interventions for the vein graft, and two graft limbs occluded during follow up.
  
  
  CONCLUSIONS
  In situ reconstruction for aortic graft infection with autologous FV presents acceptable rates of morbidity and mortality, and remains the treatment of choice for AGI at Helsinki University Hospital.
authors.affiliation: Department of Vascular Surgery, Helsinki University Hospital, Helsinki, Finland. Electronic address: ivika.heinola@hus.fi.
authors.forename: I
authors.initials: I
authors.lastname: Heinola
authors.affiliation: Department of Vascular Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: I
authors.initials: I
authors.lastname: Kantonen
authors.affiliation: Department of Vascular Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Jaroma
authors.affiliation: Department of Vascular Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Albäck
authors.affiliation: Department of Vascular Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Vikatmaa
authors.affiliation: Department of Vascular Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Aho
authors.affiliation: Department of Vascular Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Venermo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D001011:Aorta / Q000382:microbiology / Q000601:surgery*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation / Q000401:mortality; D016009:Chi-Square Distribution; D020878:Device Removal / Q000009:adverse effects / Q000401:mortality; D018572:Disease-Free Survival; D000071938:Fasciotomy; D005260:Female; D005268:Femoral Vein / Q000637:transplantation*; D005387:Finland; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality / Q000601:surgery*; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome
keywords: Aortic graft; Aortoenteric fistula; Femoral vein; Graft rupture; Infection