title: Dopamine D1 Binding Potential Predicts Fusiform BOLD Activity during Face-Recognition Performance.
abstract: The importance of face memory in humans and primates is well established, but little is known about the neurotransmitter systems involved in face recognition. We tested the hypothesis that face recognition is linked to dopamine (DA) activity in fusiform gyrus (FFG). DA availability was assessed by measuring D1 binding potential (BP) during rest using PET. We further assessed blood-oxygen-level-dependent (BOLD) signal change while subjects performed a face-recognition task during fMRI scanning. There was a strong association between D1 BP and BOLD activity in FFG, whereas D1 BP in striatal and other extrastriatal regions were unrelated to neural activity in FFG. These results suggest that D1 BP locally modulates FFG function during face recognition. Observed relationships among D1 BP, BOLD activity, and face-recognition performance further suggest that D1 receptors place constraints on the responsiveness of FFG neurons.
  
  
  CONCLUSIONS
  The importance of face memory in humans and primates is well established, but little is known about the neurotransmitter systems involved in face recognition. Our work shows a role for a specific neurotransmitter system in face memory.
authors.affiliation: School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, bart.rypma@utdallas.edu.
authors.forename: Bart
authors.initials: B
authors.lastname: Rypma
authors.affiliation: Department of Psychology, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Håkan
authors.initials: H
authors.lastname: Fischer
authors.affiliation: Aging Research Center, Karolinska Institutet, SE-113 30 Stockholm, Sweden, and.
authors.forename: Anna
authors.initials: A
authors.lastname: Rieckmann
authors.affiliation: School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Hubbard
authors.affiliation: Departments of Radiation Sciences and Integrative Medical Biology, Umeå Center for Functional Brain Imaging, Umeå University, SE-901 87 Umeå, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Nyberg
authors.affiliation: Aging Research Center, Karolinska Institutet, SE-113 30 Stockholm, Sweden, and.
authors.forename: Lars
authors.initials: L
authors.lastname: Bäckman
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D000066499:Facial Recognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*; D055815:Young Adult
chemical_list: D017447:Receptors, Dopamine D1
keywords: Dopamine; FMRI; PET; face recognition; fusiform gyrus; multimodal imaging