title: The intervention composed of aerobic training and non-exercise physical activity (I-CAN) study: Rationale, design and methods.
abstract: Recent data has suggested that prolonged sedentary behavior is independent risk factor for cardiovascular and all-cause mortality independent of adequate amounts of moderate to vigorous physical activity. However, few studies have prospectively evaluated if exercise training and increasing non-exercise physical activity leads to greater reduction in cardiometabolic risk compared to aerobic training alone. The purpose of the Intervention Composed of Aerobic Training and Non-Exercise Physical Activity (I-CAN) study is to determine whether a physical activity program composed of both aerobic training (consistent with public health recommendations) and increasing non-exercise physical activity (3000 steps above baseline levels) leads to enhanced improvements in waist circumference, oral glucose tolerance, systemic inflammation, body composition, and fitness compared to aerobic training alone in obese adults (N=45). Commercially available accelerometers (Fitbits) will be used to monitor physical activity levels and behavioral coaching will be used to develop strategies of how to increase non-exercise physical activity levels. In this manuscript, we describe the design, rationale, and methodology associated with the I-CAN study.
authors.affiliation: Department of Kinesiology, East Carolina University, Greenville, NC 27858, United States; Human Performance Laboratory, East Carolina University, Greenville, NC 27858, United States; Center for Health Disparities, East Carolina University, Greenville, NC 27858, United States. Electronic address: swiftd@ecu.edu.
authors.forename: Damon L
authors.initials: DL
authors.lastname: Swift
authors.affiliation: Department of Kinesiology, East Carolina University, Greenville, NC 27858, United States; Human Performance Laboratory, East Carolina University, Greenville, NC 27858, United States.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Dover
authors.affiliation: Department of Kinesiology, East Carolina University, Greenville, NC 27858, United States; Human Performance Laboratory, East Carolina University, Greenville, NC 27858, United States.
authors.forename: Tyara R
authors.initials: TR
authors.lastname: Nevels
authors.affiliation: Department of Psychology, East Carolina University, Greenville, NC 27858, United States.
authors.forename: Chelsey A
authors.initials: CA
authors.lastname: Solar
authors.affiliation: East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27858, United States.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Brophy
authors.affiliation: Department of Kinesiology, East Carolina University, Greenville, NC 27858, United States; Activity Promotion Laboratory, East Carolina University, Greenville, NC 27858, United States.
authors.forename: Tyler R
authors.initials: TR
authors.lastname: Hall
authors.affiliation: Department of Kinesiology, East Carolina University, Greenville, NC 27858, United States; Human Performance Laboratory, East Carolina University, Greenville, NC 27858, United States; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27858, United States.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Houmard
authors.affiliation: Department of Psychology, East Carolina University, Greenville, NC 27858, United States.
authors.forename: Lesley D
authors.initials: LD
authors.lastname: Lutes
mesh_terms: D061725:Accelerometry; D000328:Adult; D001521:Behavior Therapy / Q000379:methods; D001823:Body Composition; D015992:Body Mass Index; D015444:Exercise / Q000502:physiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009765:Obesity / Q000628:therapy*; D010809:Physical Fitness / Q000502:physiology*; D011446:Prospective Studies; D012307:Risk Factors; D055105:Waist Circumference; D061217:Weight Reduction Programs / Q000379:methods*
chemical_list: D018836:Inflammation Mediators
keywords: Exercise training; Fitbit; Methodology; Non-exercise physical activity; Obesity