title: Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate.
abstract: Fate determination in the mammalian telencephalon, with its diversity of neuronal subtypes and relevance to neuropsychiatric disease, remains a critical area of study in neuroscience. Most studies investigating this topic focus on the diversity of neural progenitors within spatial and temporal domains along the lateral ventricles. Often overlooked is whether the location of neurogenesis within a fate-restricted domain is associated with, or instructive for, distinct neuronal fates. Here, we use in vivo fate mapping and the manipulation of neurogenic location to demonstrate that apical versus basal neurogenesis influences the fate determination of major subgroups of cortical interneurons derived from the subcortical telencephalon. Somatostatin-expressing interneurons arise mainly from apical divisions along the ventricular surface, whereas parvalbumin-expressing interneurons originate predominantly from basal divisions in the subventricular zone. As manipulations that shift neurogenic location alter interneuron subclass fate, these results add an additional dimension to the spatial-temporal determinants of neuronal fate determination.
authors.affiliation: Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA; NYU Neuroscience Institute, Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Petros
authors.affiliation: Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.
authors.forename: Ronald S
authors.initials: RS
authors.lastname: Bultje
authors.affiliation: Center for Neurogenetics, Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA.
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Ross
authors.affiliation: NYU Neuroscience Institute, Department of Neuroscience and Physiology, Smilow Research Center, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Gord
authors.initials: G
authors.lastname: Fishell
authors.affiliation: Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA; Department of Psychiatry, Children's Hospital of Philadelphia and UPenn School of Medicine, Philadelphia, PA 19104, USA. Electronic address: sande@mail.med.upenn.edu.
authors.forename: Stewart A
authors.initials: SA
authors.lastname: Anderson
mesh_terms: D000818:Animals; D019070:Cell Lineage; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology; D007395:Interneurons / Q000145:classification / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D055495:Neurogenesis; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism; D013004:Somatostatin / Q000235:genetics / Q000378:metabolism; D013687:Telencephalon / Q000166:cytology / Q000196:embryology
chemical_list: D010320:Parvalbumins; D013004:Somatostatin