title: First-Trimester Maternal Abdominal Adiposity Predicts Dysglycemia and Gestational Diabetes Mellitus in Midpregnancy.
abstract: OBJECTIVE
  This study assessed the association between first-trimester abdominal adiposity and dysglycemia and gestational diabetes mellitus (GDM) in midpregnancy.
  
  
  METHODS
  In a prospective cohort of 485 women, we measured subcutaneous (SAT), visceral (VAT), and total (TAT) adipose tissue depth, using ultrasound at 11-14 weeks' gestation. Logistic regression analysis assessed the relation between quartiles of SAT, VAT, or TAT depth and the composite outcome of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or GDM, based on a 75-g oral glucose tolerance test at 24-28 weeks.
  
  
  RESULTS
  Adjusting for maternal age, ethnicity, family history of diabetes, and BMI, quartile 4 versus quartile 1 VAT (adjusted odds ratio [aOR] 3.1, 95% CI 1.1-9.5) and TAT (aOR 2.7, 95% CI 1.1-7.8) were significantly associated with the composite outcome, but SAT was not (aOR 1.8, 95% CI 0.70-4.8). The same was seen for GDM alone.
  
  
  CONCLUSIONS
  Elevated first-trimester VAT and TAT depth independently predicted the risk of dysglycemia later in pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
authors.forename: Leanne R
authors.initials: LR
authors.lastname: De Souza
authors.affiliation: Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, ON, Canada Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: Howard
authors.initials: H
authors.lastname: Berger
authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada Department of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Ravi
authors.initials: R
authors.lastname: Retnakaran
authors.affiliation: Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: Jonathon L
authors.initials: JL
authors.lastname: Maguire
authors.affiliation: Institute of Medical Science, University of Toronto, Toronto, ON, Canada Department of Surgery, Sunnybrook Health Sciences Center, Toronto, ON, Canada.
authors.forename: Avery B
authors.initials: AB
authors.lastname: Nathens
authors.affiliation: Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: Philip W
authors.initials: PW
authors.lastname: Connelly
authors.affiliation: Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada Department of Medicine, University of Toronto, Toronto, ON, Canada rayj@smh.ca.
authors.forename: Joel G
authors.initials: JG
authors.lastname: Ray
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005865:Gestational Age; D018149:Glucose Intolerance / Q000175:diagnosis / Q000453:epidemiology; D005951:Glucose Tolerance Test; D006801:Humans; D050152:Intra-Abdominal Fat / Q000503:physiopathology*; D008423:Maternal Age; D056128:Obesity, Abdominal / Q000503:physiopathology*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies