title: Roles of LIM kinases in central nervous system function and dysfunction.
abstract: LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synaptic plasticity. We also review the involvement of LIMKs in neuronal diseases and emphasize the differences in the regulation of LIMKs expression and mode of action. We finally present the existence of a cofilin-independent pathway also involved in neuronal function. A better understanding of the differences between both LIMKs and of the precise molecular mechanisms involved in their mode of action and regulation is now required to improve our understanding of the physiopathology of the neuronal diseases associated with LIMKs.
authors.affiliation: CNRS UPR 4301, CBM, Orléans, France; UMR INSERM U930, Université François-Rabelais, Tours, France.
authors.forename: H
authors.initials: H
authors.lastname: Cuberos
authors.affiliation: CNRS UPR 4301, CBM, Orléans, France.
authors.forename: B
authors.initials: B
authors.lastname: Vallée
authors.affiliation: UMR INSERM U930, Université François-Rabelais, Tours, France; CHRU de Tours, Service de Biochimie et de Biologie Moléculaire, Tours, France.
authors.forename: P
authors.initials: P
authors.lastname: Vourc'h
authors.affiliation: University Medical Center Utrecht, Brain Center Rudolf Magnus, Utrecht, Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Tastet
authors.affiliation: UMR INSERM U930, Université François-Rabelais, Tours, France; CHRU de Tours, Service de Biochimie et de Biologie Moléculaire, Tours, France.
authors.forename: C R
authors.initials: CR
authors.lastname: Andres
authors.affiliation: CNRS UPR 4301, CBM, Orléans, France.
authors.forename: H
authors.initials: H
authors.lastname: Bénédetti
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000201:enzymology* / Q000502:physiology* / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D054461:Lim Kinases / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology
chemical_list: D054461:Lim Kinases
keywords: LIM kinase 1; LIM kinase 2; Neurodegenerative disease; Neurodevelopmental disease; Neuronal function