title: Cancer Biomarkers Discovery and Validation: State of the Art, Problems and Future Perspectives.
abstract: Cancer is one of the major public health problems worldwide representing the leading cause of morbidity and mortality in industrialized countries. To reduce cancer morbidity and mortality as well as to facilitate the evolution from the traditional "one size fits all" strategy to a new "personalized" cancer therapy (i.e., the right drug to the right patient at the right time, using the right dose and schedule), there is an urgent need of reliable, robust, accurate and validated cancer biomarker tests.Unfortunately, despite the impressive advances in tumor biology research as well as in high-powerful "omics" technologies, the translation of candidate cancer biomarkers from bench to bedside is lengthy and challenging and only a few tumor marker tests have been adopted successfully into routine clinical care of oncologic patients.This chapter provides an updated background on biomarkers research in oncology, including biomarkers clinical uses, and discusses the problems of discovery pipeline, biomarkers failures and future perspectives.
authors.affiliation: Istituto di Biochimica e Biochimica Clinica, Università Cattolica del S. Cuore, Largo F. Vito 1, 00168, Roma, Italy. alvaro.mordente@rm.unicatt.it.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Mordente
authors.affiliation: Istituto di Biochimica e Biochimica Clinica, Università Cattolica del S. Cuore, Largo F. Vito 1, 00168, Roma, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Meucci
authors.affiliation: Istituto di Biochimica e Biochimica Clinica, Università Cattolica del S. Cuore, Largo F. Vito 1, 00168, Roma, Italy.
authors.forename: Giuseppe Ettore
authors.initials: GE
authors.lastname: Martorana
authors.affiliation: Istituto di Biochimica e Biochimica Clinica, Università Cattolica del S. Cuore, Largo F. Vito 1, 00168, Roma, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Silvestrini
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D055088:Early Detection of Cancer; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D011379:Prognosis; D018570:Risk Assessment
chemical_list: D014408:Biomarkers, Tumor
keywords: Biomarkers; Biomarkers failures; Cancer; Cancer biomarker: discovery and validation; Cancer control studies; Cancer therapy; Clinical assay development; Clinical uses; Discovery; Pharmacodynamic markers; Preclinical exploratory studies; Predictive markers; Prognostic markers; Prospective screening studies; Retrospective longitudinal repository studies; Risk assessment; Validation