title: Clinical significance of CD44 expression in children with hepatoblastoma.
abstract: The aim of this study was to investigate the expression of CD44 and its clinical significance in children suffering from hepatoblastoma (HB). CD44 expression was detected with immunohistochemistry staining in 30 samples from hepatoblastoma children and 10 normal liver tissue samples from normal children. The data obtained was statistically analyzed using the chi-square test, using the SPSS (v.11.0) software. The rate of CD44 expression was significantly higher (66.7%) in hepatoblastoma tissues than in normal liver tissues (χ(2) = 4.848, P < 0.05). The rate of CD44 expression was significantly higher in children with stage III or IV hepatoblastoma (83.3%) than that in children with stage I and II hepatoblastoma (χ(2) ＝ 5.625, P < 0.05) (41.7%). Therefore, CD44 expression might play an important role in the pathogenesis, progression, and prognosis of HB in children.
authors.affiliation: Department of General Surgery, General Hospital of Beijing Military Region, Beijing, China.
authors.forename: H-Y
authors.initials: HY
authors.lastname: Cai
authors.affiliation: Department of General Surgery, General Hospital of Beijing Military Region, Beijing, China.
authors.forename: B
authors.initials: B
authors.lastname: Yu
authors.affiliation: Ba Yi Children's Hospital Affiliated Beijing Military General Hospital, No. 5 Nan Men Cang, East District, Beijing, China.
authors.forename: Z-C
authors.initials: ZC
authors.lastname: Feng
authors.affiliation: Department of General Surgery, General Hospital of Beijing Military Region, Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of General Surgery, General Hospital of Beijing Military Region, Beijing, China.
authors.forename: X-J
authors.initials: XJ
authors.lastname: Wei
mesh_terms: D002648:Child; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D018197:Hepatoblastoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics / Q000378:metabolism*; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D018960:Hyaluronan Receptors