title: Primary salivary duct carcinoma of the lung, mucin-rich variant.
abstract: Primary salivary gland-type lung cancer is a heterogeneous group of neoplasms arising from the seromucinous glands of the respiratory tract. Histopathologically, they are identical to salivary gland neoplasms of the head and neck. While mucoepidermoid carcinoma and adenoid cystic carcinoma are overwhelmingly the most common subtypes found in the lung, reports of uncommon subtypes can be found in the literature. We report a case of a 73-year-old woman with primary lung salivary duct carcinoma, mucin-rich variant--an exceedingly rare subtype of an already rare malignant salivary-type neoplasm. One case of primary lung salivary duct carcinoma has been reported in the literature; however, the mucin-rich variant has never been described in the lung. Furthermore, the tumor in our case bears a rare BRAF G464V mutation. To our knowledge, this is the first reported case of a BRAF G464V mutation detected in a salivary duct carcinoma or any other salivary-type neoplasm.
authors.affiliation: David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: gfishbein@mednet.ucla.edu.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Fishbein
authors.affiliation: David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Brandon S
authors.initials: BS
authors.lastname: Grimes
authors.affiliation: David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Rena R
authors.initials: RR
authors.lastname: Xian
authors.affiliation: David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Jay M
authors.initials: JM
authors.lastname: Lee
authors.affiliation: David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Igor
authors.initials: I
authors.lastname: Barjaktarevic
authors.affiliation: David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Haodong
authors.initials: H
authors.lastname: Xu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008197:Lymph Node Excision; D009077:Mucins / Q000032:analysis*; D064847:Multimodal Imaging / Q000379:methods; D009154:Mutation; D011013:Pneumonectomy; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D018987:Salivary Ducts / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D009077:Mucins; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF; Lung cancer; Non-small cell lung cancer; Salivary duct carcinoma; Salivary gland tumor