title: Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited.
abstract: Oral ulcers are a common symptom in clinical practice. Among various causative factors, different types of ulcers in oral cavity exist. Among this, traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) appears to be quite neglected by the clinicians due to the limited knowledge and awareness. On reviewing with a detailed approach to titles and abstracts of articles eliminating duplicates, 40 relevant articles were considered. Randomized studies, review articles, case reports and abstracts were included while conference papers and posters were excluded. Of importance, TUGSE cases been reported only to a minimal extent in the literature. Lack of its awareness tends to lead clinicians to a misconception of cancer. Thus, this particular lesion needs to be differentiated from other malignant lesions to provide a proper mode of treatment. The present article reviews various aspects of the TUGSE with emphasis on the clinical manifestation, pathogenesis, histological, and immunohistochemical study. This study provides the clinician contemporaries, a humble expansion to their knowledge of the disease, based on the searched literature, enabling a more comprehensive management of this rare occurrence.
authors.affiliation: Department of Oral Pathology, Madha Dental College and Hospital, Kundrathur, India.
authors.forename: R
authors.initials: R
authors.lastname: Sarangarajan
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Asian Institute of Medicine Science and Technology (AIMST) University, Malaysia.
authors.forename: V K
authors.initials: VK
authors.lastname: Vaishnavi Vedam
authors.affiliation: Department of Pedodontics, Faculty of Dentistry, Asian Institute of Medicine Science and Technology (AIMST) University, Malaysia.
authors.forename: G
authors.initials: G
authors.lastname: Sivadas
authors.affiliation: Private Dental Practitioner, Sai Raghav Dental Clinic, West Mambalam, Chennai, Tamil Nadu, India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Sarangarajan
authors.affiliation: Private Dental Practitioner, Sree Sai Dental Care, Kolapakkam, Chennai, Tamil Nadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Meera
keywords: CD30+; Riga-Fede disease; lymphoproliferative disorders; oral ulcer; traumatic ulcerative granuloma with stromal eosinophilia; ulcerative granuloma