title: CHOROIDAL THICKENING IN PATIENTS WITH CUTICULAR DRUSEN COMBINED WITH VITELLIFORM MACULAR DETACHMENT.
abstract: OBJECTIVE
  To analyze the subfoveal choroidal thickness (SFCT) in patients with cuticular drusen.
  
  
  METHODS
  Retrospective, monocentric, study of consecutive patients examined with enhanced depth imaging spectral domain optical coherence tomography (EDI SD-OCT, Cirrus, Zeiss) between 2009 and 2014 in a tertiary care center. Measurements of the height of the subfoveal vitelliform detachment and SFCT were manually performed.
  
  
  RESULTS
  Thirteen patients, 3 men and 10 women, aged from 35 to 73 (mean: 53.6 years) were selected. For the 24 eyes without macular atrophy at first visit, SFCT ranged from 195 to 559 µm (mean ± SD = 317.5 ± 93). The SFCT was significantly thicker in 12 eyes with vitelliform macular detachment at presentation (369 ± 96, median = 368.5) than in 12 eyes without (266 ± 58, median = 257.5) (P = 0.007), whereas the 2 groups did not differ in age (P = 0.35) or refractive error (P = 0.56). No correlation was observed between SFCT and the height of the foveal detachment. For 10 eyes followed up longer than 24 months (mean: 38.9 months), the SFCT significantly decreased over time, from 375 ± 96 (median = 368.5) to 303 ± 138 (median = 319) µm (P = 0.022).
  
  
  CONCLUSIONS
  Eyes with cuticular drusen combined with vitelliform macular detachment present with choroidal thickening, suggesting that the choroidal vasculature may play a role in the occurrence of macular detachments in patients with cuticular drusen. The life cycle of these vitelliform lesions evolves from translucent subretinal fluid to the accumulation of yellowish material eventually resolving and leading to atrophy with marked and rapid thinning of the choroid.
authors.affiliation: Ophthalmic Center for Imaging and Laser, Paris, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Mrejen-Uretsky
authors.forename: Sandrine
authors.initials: S
authors.lastname: Ayrault
authors.forename: Sylvia
authors.initials: S
authors.lastname: Nghiem-Buffet
authors.forename: Gabriel
authors.initials: G
authors.lastname: Quentel
authors.forename: Salomon Y
authors.initials: SY
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000368:Aged; D016570:Bruch Membrane / Q000000981:diagnostic imaging / Q000473:pathology*; D002829:Choroid / Q000000981:diagnostic imaging / Q000473:pathology*; D015785:Eye Diseases, Hereditary / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009929:Organ Size; D012163:Retinal Detachment / Q000150:complications* / Q000000981:diagnostic imaging; D015593:Retinal Drusen / Q000150:complications* / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D058471:Subretinal Fluid; D062606:Tertiary Care Centers; D041623:Tomography, Optical Coherence; D057826:Vitelliform Macular Dystrophy / Q000150:complications* / Q000000981:diagnostic imaging