title: [Epidemiologic Survey of Blood Donors with HBsAg⁻/HBV DNA⁺ in Chinese Xiamen Area].
abstract: OBJECTIVE
  To understand the characteristics of infections from blood donors with HBsAg⁻/HBV DNA⁺ in Xiamen area.
  
  
  METHODS
  Donors in Xiamen area were assayed by routine ELISA and those with negative results were tested by nucleic acid amplification testing (NAT). HBsAg⁻/HBV DNA⁺ samples were tested by quantitative detection of HBV DNA. Epidemiological analysis and following up examination were conducted in HBsAg⁻/HBV DNA⁺ donors.
  
  
  RESULTS
  Out of 130659 samples 113 were tested as HBsAg⁻/HBV DNA⁺ and with a rate of 0.09%. Among those, 62 samples were tested by quantitative detection of HBV DNA. All of the quantitative results were less than 1 × 10³ IU/ml and 93.5% (58/62) of which were less than 100 IU/ml. The possitive rate of HBsAg⁻/HBV DNA⁺ donors rose with ages. The possitive rate in male donors was higher than that in female and was lower in highly educated ones. Students and public servants had a lower positive rate.
  
  
  CONCLUSIONS
  The possitive rate of HBsAg⁻/HBV DNA⁺ donors is higher in Xiamen and the distribution of possitive donors has certain epidemiological characteristics. It is necessary to mobilize and recruit more people with a lower rate of HBsAg⁻/HBV DNA⁺ infection.
authors.affiliation: Xiamen Blood Center, Xiamen 361004, Fujian Province, China.
authors.forename: Shan-Hai
authors.initials: SH
authors.lastname: Ou
authors.affiliation: Xiamen Blood Center, Xiamen 361004, Fujian Province, China.
authors.forename: Jin-Zhen
authors.initials: JZ
authors.lastname: Xia
authors.affiliation: Xiamen Blood Center, Xiamen 361004, Fujian Province, China.
authors.forename: Yong-Cai
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Xiamen Blood Center, Xiamen 361004, Fujian Province, China. E-mail: ccr1969@163.com.
authors.forename: Chang-Rong
authors.initials: CR
authors.lastname: Chen
mesh_terms: D044466:Asian People; D001782:Blood Donors; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus; D006801:Humans; D008297:Male; D021141:Nucleic Acid Amplification Techniques
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens