title: Design and synthesis of a new chromophore, 2-(4-nitrophenyl)benzofuran, for two-photon uncaging using near-IR light.
abstract: A new chromophore, 2-(4-nitrophenyl)benzofuran (NPBF), was designed for two-photon (TP) uncaging using near-IR light. The TP absorption (TPA) cross-sections of the newly designed NPBF chromophore were determined to be 18 GM at 720 nm and 54 GM at 740 nm in DMSO. The TP uncaging reaction of a caged benzoate with the NPBF chromophore quantitatively produced benzoic acid with an efficiency (δu) of ∼5.0 GM at 740 nm. The TP fragmentation of an EGTA unit was observed with δu = 16 GM. This behavior makes the new chromophore a promising TP photoremovable protecting group for physiological studies.
authors.affiliation: Department of Chemistry, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-hiroshima, Hiroshima 739-8526, Japan. mabe@hiroshima-u.ac.jp.
authors.forename: Naomitsu
authors.initials: N
authors.lastname: Komori
authors.forename: Satish
authors.initials: S
authors.lastname: Jakkampudi
authors.forename: Ryusei
authors.initials: R
authors.lastname: Motoishi
authors.forename: Manabu
authors.initials: M
authors.lastname: Abe
authors.forename: Kenji
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authors.lastname: Kamada
authors.forename: Ko
authors.initials: K
authors.lastname: Furukawa
authors.forename: Claudine
authors.initials: C
authors.lastname: Katan
authors.forename: Wakako
authors.initials: W
authors.lastname: Sawada
authors.forename: Noriko
authors.initials: N
authors.lastname: Takahashi
authors.forename: Haruo
authors.initials: H
authors.lastname: Kasai
authors.forename: Bing
authors.initials: B
authors.lastname: Xue
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Kobayashi