title: Systemic Teriparatide Administration Promotes Osseous Regeneration of an Intrabony Defect: A Case Report.
abstract: BACKGROUND
  Teriparatide comprises the first 34 amino acids of parathyroid hormone and is a systemic anabolic agent that is Food and Drug Administration approved for the treatment of osteoporosis but not for periodontitis. To our knowledge, this is the first clinical case report to document the treatment of a patient with severe periodontitis using an open-flap debridement procedure in conjunction with teriparatide.
  
  
  METHODS
  A 45-year-old female patient was diagnosed with severe chronic periodontitis, including the presence of an intrabony defect on tooth #6. She received open-flap debridement surgery in conjunction with daily systemic administration of 20 μg teriparatide, oral vitamin D, and calcium supplements for 6 weeks. Radiographic, clinical, gingival crevicular fluid (pyridinoline cross-linked carboxy-terminal propeptide of type I procollagen, procollagen type 1 N-propeptide, and osteocalcin), and serum parameters (parathyroid hormone, bone alkaline phosphatase, calcium, and 25-hydroxyvitamin D) were assessed. Treatment outcomes were evaluated over 4 years, with successful radiographic and clinical results throughout the follow-up period.
  
  
  CONCLUSIONS
  Teriparatide administration in conjunction with traditional open-flap debridement surgery offers potential for the treatment of severe intrabony defects resulting from chronic periodontitis.
authors.affiliation: Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.
authors.forename: Jill D
authors.initials: JD
authors.lastname: Bashutski
authors.affiliation: Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.
authors.forename: Janet S
authors.initials: JS
authors.lastname: Kinney
authors.affiliation: Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.
authors.forename: Erika
authors.initials: E
authors.lastname: Benavides
authors.affiliation: Department of Biostatistics, School of Public Health, University of Michigan.
authors.forename: Samopriyo
authors.initials: S
authors.lastname: Maitra
authors.affiliation: Department of Biostatistics, School of Public Health, University of Michigan.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Braun
authors.affiliation: Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.|Biomedical Engineering, College of Engineering, University of Michigan.
authors.forename: William V
authors.initials: WV
authors.lastname: Giannobile
authors.affiliation: Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.|Department of Pathology, Medical School, University of Michigan.
authors.forename: Laurie K
authors.initials: LK
authors.lastname: McCauley
authors.affiliation: Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Eber
keywords: Bone regeneration; guided tissue regeneration; parathyroid hormone; periodontal attachment loss; periodontal bone loss; teriparatide