title: Association of Cytokine Production with Hormone Level and Sensory Responses during the Formation of Psychoactive Drug Addiction in Men.
abstract: We performed immunophysiological examination of 144 men aged 17-25 years, patients with psychoactive substance dependence, episodic psychoactive drug users, and conditionally healthy individuals. Associations of proinflammatory cytokine production with age, sex, hormone levels, and olfactory and nociceptive indices were revealed in cases of psychoactive drug use and formation of addiction. Predictive models based on the use of androstenone aversion, pressure algometry testing, and immunological parameters were proposed.
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia. nevidimova@yandex.ru.
authors.forename: T I
authors.initials: TI
authors.lastname: Nevidimova
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Batukhtina
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: T P
authors.initials: TP
authors.lastname: Vetlugina
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: D N
authors.initials: DN
authors.lastname: Savochkina
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: V B
authors.initials: VB
authors.lastname: Nikitina
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Lobacheva
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Bokhan
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D006728:Hormones / Q000097:blood*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D059225:Nociception / Q000502:physiology*; D011619:Psychotropic Drugs; D012903:Smell / Q000502:physiology*; D019966:Substance-Related Disorders / Q000097:blood* / Q000523:psychology*; D055815:Young Adult
chemical_list: D016207:Cytokines; D006728:Hormones; D018836:Inflammation Mediators; D011619:Psychotropic Drugs
keywords: addiction; androstenone; cytokines; pain