title: Interventional Ischemic Stroke Treatment--A (R)evolution.
abstract: In recent years ischemic stroke caused by an intracranial vessel occlusion has become a treatable disease. Over decades intravenous thrombolysis by recombinant tissue plasminogen activator was the only accepted causal treatment of ischemic stroke supported by the results of randomized, controlled trials. However, there has been continuous development of endovascular treatment strategies over recent years. Today there are 5 prospective, randomized multicenter studies showing the highly significant superiority of endovascular, mechanical recanalization over intravenous thrombolysis in cases of acute occlusion of an intracranial vessel of the anterior circulation. In all those studies endovascular treatment resulted in a tremendous increase in functional independence together with a reduction of mortality without a significant increase in complications. This article reviews the developments resulting in the current data and gives an overview of the present studies focusing on endovascular stroke treatment.
  
  
  CONCLUSIONS
  • In the last 20 years ischemic stroke due to an main stem occlusion has become a potentially treatable disease. • Several in 2015 published randomized Multicenter trials could prove the superiority of endovascular, mechanical recanalization over i.v. thrombolysis alone. • Acute ischemic stroke due to a main stem occlusion should be treated with swift endovascular stent-retriever based recanalization in specialized neurovascular centers.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Friedrich
authors.affiliation: Department of Neuroradiology, University Hospital Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Gawlitza
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Fahnert
authors.affiliation: Department of Neuroradiology, University Hospital Leipzig, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Quäschling
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Kahn
authors.affiliation: Department of Neuroradiology, University Hospital Leipzig, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Lobsien
authors.affiliation: Department of Neuroradiology, University Hospital Leipzig, Germany.
authors.forename: K-T
authors.initials: KT
authors.lastname: Hoffmann
mesh_terms: D001807:Blood Vessel Prosthesis; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000628:therapy*; D057510:Endovascular Procedures / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D015641:Radiography, Interventional / Q000379:methods*; D015607:Stents; D020521:Stroke / Q000000981:diagnostic imaging / Q000628:therapy*; D016896:Treatment Outcome