title: Correlation between expression and significance of δ-catenin, CD31, and VEGF of non-small cell lung cancer.
abstract: We analyzed the expression and clinical significance of δ-catenin in non-small cell lung cancer (NSCLC) and investigated prognosis using human lung cancer samples. Eighty-nine NSCLC patients underwent operation between January and March 2009. There were 53 cases of squamous cell carcinoma, 31 adenocarcinoma, and 5 large cell carcinoma. δ-Catenin in NSCLC patients was detected by immunohistochemistry and analyzed in combination with the clinicopathological characteristics of lung cancer. The relationship between δ-catenin and CD31, D2-40, and vascular endothelial growth factor (VEGF) was compared by immunohistochemistry and the χ(2) test. δ-Catenin appeared in the cytoplasm of adjacent bronchial epithelial cells, indicating negative expression. Positive δ-catenin expression in the cytoplasm of lung cancer tissues was 66.67% (52/78), which was significantly higher than in normal lung tissues. Kaplan-Meier survival analysis suggested that the mean survival time of patients with δ-catenin-positive expression was significantly shorter than in those with negative expression, indicating that positive expression was closely related to poor prognosis of NSCLC. δ-Catenin was highly expressed in NSCLC mainly in the cytoplasm of lung cancer tissues. δ-Catenin-positive expression may be related to poor prognosis of NSCLC. High δ-catenin expression in NSCLC was positively correlated with high CD31 and VEGF expression, but not correlated with D2-40, suggesting that δ-catenin may be related to angiogenesis and not lymphangiogenesis.
authors.affiliation: Thoracic Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Anesthesiology, Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: L D
authors.initials: LD
authors.lastname: Liu
authors.affiliation: Thoracic Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: S G
authors.initials: SG
authors.lastname: Zhang
authors.affiliation: Department of Pathology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: S D
authors.initials: SD
authors.lastname: Dai
authors.affiliation: Thoracic Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Li
authors.affiliation: Thoracic Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D051177:Catenins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D000095002:Delta Catenin
chemical_list: D051177:Catenins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D042461:Vascular Endothelial Growth Factor A; D000095002:Delta Catenin