title: [Blood-brain barrier permeability in healthy rats and rats with experimental C6 glioma after fractionated radiotherapy of the brain].
abstract: To evaluate the effect of fractionated radiotherapy on permeability of the blood-brain barrier in healthy rats and rats with C6 glioma in vivo.
  
  
  
  An increase in BBB permeability in C6 glioma was assessed by dynamic MRI monitoring (glioma size before and after radiation therapy in combination with immunotherapy, n=30) and confocal microscopy (fluorescence imaging of tumor invasion boundaries in a dose-dependent experiment for the amount of injected antibodies). In healthy rats, BBB permeability to macromolecular substances (MMS) was assessed by ELISA (n=23, 192 plasma samples) and confocal microscopy (n=7).
  
  
  
  It was shown that BBB permeability to biological macromolecules in blood-brain and brain-blood directions was increased after fractionated radiotherapy.
  
  
  
  Drug delivery to the brain can be improved using therapeutic doses of radiation treatment that affects the BBB and minimizes the risk of serious side effects that are often associated with the drug dose.
authors.affiliation: V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology.
authors.forename: G M
authors.initials: GM
authors.lastname: Yusubalieva
authors.affiliation: N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology.
authors.forename: A B
authors.initials: AB
authors.lastname: Levinskiy
authors.affiliation: V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology.
authors.forename: Ya A
authors.initials: YA
authors.lastname: Zorkina
authors.affiliation: N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology.
authors.forename: V P
authors.initials: VP
authors.lastname: Baklaushev
authors.affiliation: Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences.
authors.forename: S A
authors.initials: SA
authors.lastname: Goryaynov
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences.
authors.forename: G V
authors.initials: GV
authors.lastname: Pavlova
authors.affiliation: N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology.
authors.forename: P A
authors.initials: PA
authors.lastname: Mel'nikov
authors.affiliation: V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology; Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences; Institute of Gene Biology, Russian Academy of Sciences.
authors.forename: G E
authors.initials: GE
authors.lastname: Gorlachev
authors.affiliation: V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology; Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences; Institute of Gene Biology, Russian Academy of Sciences.
authors.forename: A V
authors.initials: AV
authors.lastname: Golanov
authors.affiliation: Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences.
authors.forename: A A
authors.initials: AA
authors.lastname: Potapov
authors.affiliation: V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Department of Fundamental and Applied Neurobiology; N.I. Pirogov Russian State Medical University, Department of Medical Nano-biotechnology.
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002199:Capillary Permeability; D019583:Dose Fractionation, Radiation; D005910:Glioma / Q000532:radiotherapy*; D016499:Radioimmunotherapy; D051381:Rats; D017208:Rats, Wistar