title: Cytotoxicity of 1-dodecyl-3-methylimidazolium bromide on HepG2 cells.
abstract: We evaluated the cytotoxicity of 1-dodecyl-3-methylimidazo-lium bromide ([C12mim][Br]) on HepG2 cells and its influence on plasma membrane permeability. The results showed that [C12mim][Br] inhibited HepG2 cell growth and decreased cell viability in a concentration-depen-dent manner. The results also revealed that [C12mim][Br] exposure induced apoptosis in [C12mim][Br]-treated HepG2 cells. In addition, the results showed that [C12mim][Br] increased membrane permeability in HepG2 cells. These results suggest that plasma membrane permeability may be responsible for apoptosis induced by [C12mim][Br] in HepG2 cells.
authors.affiliation: College of Life Sciences and Technology, Xinxiang Medical University, Henan, China.
authors.forename: T H
authors.initials: TH
authors.lastname: Li
authors.affiliation: College of Life Sciences and Technology, Xinxiang Medical University, Henan, China.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Jing
authors.affiliation: College of Life Sciences and Technology, Xinxiang Medical University, Henan, China.
authors.forename: K L
authors.initials: KL
authors.lastname: Gao
authors.affiliation: College of Life Sciences and Technology, Xinxiang Medical University, Henan, China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Yue
authors.affiliation: Department of Neurology, the Third Affiliated Hospital, Xinxiang Medical University, Henan, China asd297108065@163.com.
authors.forename: S F
authors.initials: SF
authors.lastname: Li
mesh_terms: D001965:Bromides / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: C521425:1-dodecyl-3-methylimidazolium; D001965:Bromides; D007093:Imidazoles