title: Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.|College of Life Sciences, Nankai University, Tianjin, 300071, China.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Tashiro
authors.affiliation: Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Nagatoishi
authors.affiliation: Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Onna-son, Kunigami, Okinawa, 904-0412, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.|College of Life Sciences, Nankai University, Tianjin, 300071, China.
authors.forename: Dongke
authors.initials: D
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.|College of Life Sciences, Nankai University, Tianjin, 300071, China.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Liu
authors.affiliation: Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. tsumoto@ims.u-tokyo.ac.jp.
authors.forename: Kouhei
authors.initials: K
authors.lastname: Tsumoto
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. bartlam@nankai.edu.cn.|College of Life Sciences, Nankai University, Tianjin, 300071, China. bartlam@nankai.edu.cn.
authors.forename: Mark
authors.initials: M
authors.lastname: Bartlam
authors.affiliation: Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Onna-son, Kunigami, Okinawa, 904-0412, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology*; D014157:Transcription Factors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D054852:Small Molecule Libraries; C098669:TOB1 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins