title: Acute kidney injury in hematological patients.
abstract: OBJECTIVE
  The present article reviews the recent literature on the main aspects of acute kidney injury (AKI) developing in patients with hematological malignancies admitted to ICU.
  
  
  RESULTS
  Up to two thirds of critically ill patients with hematological malignancies develop AKI. Current mortality rates range from 40 to 60% for most patients with hematological malignancies, except for recipients of allogeneic hematopoietic stem cell transplantation in whom outcomes remain very poor. Renal function recovery occurs in most patients with AKI, but is dependent on the underlying causes. AKI is usually multifactorial, resulting from causes common to other ICU patients and related to the underlying malignancy or its treatment. New targeted therapies and treatment strategies are potentially associated with AKI. Management of these patients requires a high degree of suspicion, close monitoring of metabolic parameters, and use of preventive strategies to limit risk of AKI or to mitigate its severity.
  
  
  CONCLUSIONS
  AKI is a frequent and severe complication in critically ill patients with hematological malignancies. As the clinical management is complex, close collaboration with hematologists is paramount.
authors.affiliation: aMedical Intensive Care Unit, Saint-Louis University Hospital, Paris bMedical-Surgical Intensive Care Unit, Intercommunal Hospital Le Raincy-Montfermeil, Montfermeil cMedical-Surgical Intensive Care Unit, Saint-Etienne University Hospital, Saint-Priest-En-Jarez and Jean Monnet Medical School, Saint-Etienne, France dDepartment of Critical Care, D'Or Institute for Research and Education ePost-Graduation Program, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Canet
authors.forename: François
authors.initials: F
authors.lastname: Vincent
authors.forename: Michael
authors.initials: M
authors.lastname: Darmon
authors.forename: Marcio
authors.initials: M
authors.lastname: Soares
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D000970:Antineoplastic Agents / Q000633:toxicity; D016638:Critical Illness; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D011379:Prognosis; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents