title: [VITAMIN D AND CHRONIC LUNG COLONIZATION IN PEDIATRIC AND YOUNG ADULTS CYSTIC FIBROSIS PATIENTS].
abstract: OBJECTIVE
  evaluate vitamin D status and its association with chronic lung colonisation in Cystic Fibrosis patients.
  
  
  METHODS
  descriptive cross-sectional multicenter study. From November 2012 to April 2014, at 12 national hospitals, 377 patients with Cystic Fibrosis were included. Vitamin D levels < 30 ng/ml were classified as insufficient. Chronic colonisation was considered if they had at least two positive cultures in the past year.
  
  
  RESULTS
  the median age was 8.9 years (2 months to 20 years). 65% had insufficient levels of vitamin D. There was an inverse correlation between age and vitamin D levels (r = -0.20 p < 0.001). Those diagnosed by screening, were younger and had higher levels of vitamin D. There was an inverse correlation between the number of colonisations and vitamin D levels (r = -0.16 p = 0.0015). Adjusting for age, pancreatic status and diagnosis by screening, colonization by S. aureus in 6 years, increased the risk of insufficient levels of vitamin D: OR 3.17 (95% CI 1.32 to 7.61) (p = 0.010) and OR 3.77 (95% CI 1.37 to 10 , 37) (p = 0.010), respectively.
  
  
  CONCLUSIONS
  despite adequate supplementation, more than half of our patients did not achieve optimal levels of vitamin D. Regardless of age, diagnosis by screening or pancreatic status, chronic colonization by Pseudomonas sp. in children and adolescents and S. Aureus in infants and preschoolars increases the risk of developing vitamin D deficiency in these patients.
authors.affiliation: Gastroenterología y Nutrición Pediátrica. Hospital Universitario Central de Asturias, Oviedo.. domixixon@gmail.com.
authors.forename: David
authors.initials: D
authors.lastname: González Jiménez
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Infantil Universitario Niño Jesús, Madrid.. rosana.munozcodoceo@gmail.com.
authors.forename: Rosana
authors.initials: R
authors.lastname: Muñoz Codoceo
authors.affiliation: Unidad de Fibrosis Quística. Hospital Universitario Ramón y Cajal, Madrid.. maria.garriga@salud.madrid.org.
authors.forename: María
authors.initials: M
authors.lastname: Garriga García
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Universitario La Paz, Madrid.. Manuel.Molina@salud.madrid.org.
authors.forename: Manuel
authors.initials: M
authors.lastname: Molina Arias
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Universitario Vall d'Hebron, Barcelona.. alvarezbeltran@hotmail.com.
authors.forename: Marina
authors.initials: M
authors.lastname: Alvarez Beltran
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Universitario Miguel Servet, Zaragoza.. ruthgarciaromero@yahoo.es.
authors.forename: Ruth
authors.initials: R
authors.lastname: García Romero
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Clínico Universitario de Valencia.. cecilia.martinez@uv.es.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Martínez Costa
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Sant Joan de Deu, Barcelona.. smeavilla@hsjdbcn.org.
authors.forename: Silvia María
authors.initials: SM
authors.lastname: Meavilla Olivas
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Universitario Materno-Infantil de Canarias, Las Palmas de Gran Canaria.. lpena@dcc.ulpgc.es.
authors.forename: Luis
authors.initials: L
authors.lastname: Peña Quintana
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Regional Universitario Carlos Haya de Málaga.. sgallegog@hotmail.com.
authors.forename: Silvia
authors.initials: S
authors.lastname: Gallego Gutierrez
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Clínico Universitario de Valladolid.. jmmarugan@telefonica.net.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Marugan de Miguelsanz
authors.affiliation: Unidad de Fibrosis Quística. Hospital Universitario Ramón y Cajal, Madrid.. lucrecia.suarez@salud.madrid.org.
authors.forename: Lucrecia
authors.initials: L
authors.lastname: Suarez Cortina
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Sant Joan de Deu, Barcelona.. ecastejon@hsjdbcn.org.
authors.forename: Esperanza Natividad
authors.initials: EN
authors.lastname: Castejón Ponce
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Clínico Universitario de Santiago de Compostela. España.. mariarosaura.leis@usc.es.
authors.forename: Rosaura
authors.initials: R
authors.lastname: Leis Trabazo
authors.affiliation: Gastroenterología y nutrición pediátrica. Hospital Universitario Materno-Infantil de Canarias, Las Palmas de Gran Canaria.. faynamc87@gmail.com.
authors.forename: Fayna
authors.initials: F
authors.lastname: Martín Cruz
authors.affiliation: Gastroenterología y Nutrición Pediátrica. Hospital Universitario Central de Asturias, Oviedo.. juanjo.diazmartin@gmail.com.
authors.forename: Juan Jose
authors.initials: JJ
authors.lastname: Díaz Martín
authors.affiliation: Gastroenterología y Nutrición Pediátrica. Hospital Universitario Central de Asturias, Oviedo.. ringerbou@yahoo.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: Bousoño García
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D008168:Lung / Q000382:microbiology*; D008297:Male; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications; D014815:Vitamins / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D014815:Vitamins; D014807:Vitamin D