title: Antimicrobial Assessment of Resins from Calophyllum Antillanum and Calophyllum Inophyllum.
abstract: The Calophyllum genus is well-known for its antimicrobial and cytotoxic activities, and therefore, we analyzed these biological activities for resins of Calophyllum antillanum and Calophyllum inophyllum growing in Cuba. C. antillanum resins showed a potent activity against Plasmodium falciparum (IC50  = 0.3 ± 0.1 µg/mL), while its cytotoxicity against MRC-5 cells was much lower (IC50  = 21.6 ± 1.1 µg/mL). In contrary, the resin of C. inophyllum showed an unspecific activity. The presence of apetalic acid, isoapetalic acid, calolongic acid, pinetoric acid I, pinetoric acid II, isocalolongic acid, pinetoric acid III, and isopinetoric acid III in C. antillanum resins was also confirmed. These results demonstrated for the first time the potential activity of C. antillanum resins against P. falciparum.
authors.affiliation: Academic Unit of Chemical Sciences and Health, Technical University of Machala, Machala, Ecuador.
authors.forename: Osmany
authors.initials: O
authors.lastname: Cuesta-Rubio
authors.affiliation: Institute of pharmacy and Food, Havana University, Havana, Cuba.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Oubada
authors.affiliation: University of Guayaquil, Guayaquil, Ecuador.
authors.forename: Adonis
authors.initials: A
authors.lastname: Bello
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium.
authors.forename: Louis
authors.initials: L
authors.lastname: Maes
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium.
authors.forename: Paul
authors.initials: P
authors.lastname: Cos
authors.affiliation: Department of Parasitology, Institute of Tropical Medicine "Pedro Kouri", Havana, Cuba.
authors.forename: Lianet
authors.initials: L
authors.lastname: Monzote
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D029759:Calophyllum / Q000737:chemistry* / Q000145:classification; D002176:Candida albicans / Q000187:drug effects; D002460:Cell Line; D002867:Chromones / Q000302:isolation & purification / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology; D018314:Leishmania infantum / Q000187:drug effects; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D012116:Resins, Plant / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects; D014345:Trypanosoma / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D002867:Chromones; D007529:Isoflavones; D012116:Resins, Plant; C570384:apetalic acid; C531873:pinetoric acid I; C531874:pinetoric acid II
keywords: Calophyllum antillanum; Calophyllum inophyllum; Plasmodium falciparum; antimicrobial