title: Selective Alkenylation and Hydroalkenylation of Enol Phosphates through Direct C-H Functionalization.
abstract: An efficient and selective Rh-catalyzed direct CH functionalization reaction of enol phosphates was developed. The method is applicable to a variety of coupling partners, including activated alkenes, alkynes, and allenes, and leads to the formation of various valuable alkenylated and hydroalkenylated enol phosphates through the action of the phosphate directing group. The versatility and utility of the coupling products were demonstrated through further transformations into synthetically useful building blocks.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore).
authors.forename: Xu-Hong
authors.initials: XH
authors.lastname: Hu
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore).
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Yang
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China). teckpeng@ntu.edu.sg.|Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore). teckpeng@ntu.edu.sg.
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh
keywords: CH activation; alkenylation; enol phosphates; hydroalkenylation; rhodium