title: Contrast-enhanced ultrasound in ovarian tumors - diagnostic parameters: method presentation and initial experience.
abstract: The aim of this paper is to discuss and illustrate the use of contrast-enhanced ultrasound in evaluating ovarian tumors compared to conventional ultrasound, Doppler ultrasound and the histopathological analysis and suggest how this technique may best be used to distinguish benign from malignant ovarian masses. We present the method and initial experience of our center by analyzing the parameters used in contrast-enhanced ultrasound in 6 patients with ovarian tumors of uncertain etiology. For examination we used a Siemens ultrasound machine with dedicated contrast software and the contrast agent SonoVue, Bracco. The patients underwent conventional ultrasound, Doppler ultrasound and i.v. administration of the contrast agent. The parameters studied were: inflow of contrast (rise time), time to peak enhancement, mean transit time. The series of patients is part of an extensive prospective PhD study aimed at elaborating a differential diagnosis protocol for benign versus malignant ovarian tumors, by validating specific parameters for contrast-enhanced ultrasound. Although the method is currently used with great success in gastroenterology, urology and senology, its validation in gynecology is still in the early phases. Taking into consideration that the method is minimally invasive and much less costly that CT/MRI imaging, demonstrating its utility in oncologic gynecology would be a big step in preoperative evaluation of these cases.
authors.affiliation: Department of Obstetrics and Gynaecology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, "Dominic Stanca" Clinic Cluj-Napoca, Romania.
authors.forename: Anita-Roxana
authors.initials: AR
authors.lastname: Maxim
authors.affiliation: Department of Medical Imaging, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Regional Gastroenterology and Hepatology Institute "Prof. Dr. Octavian Fodor" Cluj-Napoca, Romania.
authors.forename: Radu
authors.initials: R
authors.lastname: Badea
authors.affiliation: Department of Medical Imaging, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Regional Gastroenterology and Hepatology Institute "Prof. Dr. Octavian Fodor" Cluj-Napoca, Romania.
authors.forename: Atilla
authors.initials: A
authors.lastname: Tamas
authors.affiliation: Department of Oncologic Surgery, Oncology Institute "Prof. Dr. I. Chiricuţă" Cluj-Napoca, Romania.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Traila
keywords: contrast parameters; contrast-enhanced ultrasound; ovarian tumor