title: Shape-controlled gold nanoparticles supported on MoS₂ nanosheets: synergistic effect of thionine and MoS₂ and their application for electrochemical label-free immunosensing.
abstract: Herein, a facile approach for shape-controlled gold nanoparticle (AuNP) decorated thionine-MoS2 nanocomposites (AuNP-Thi-MoS2) had been reported by using the synergistic effect of MoS2 and Thi. Thi was not only used as an electrochemical indicator, but also as a reducing agent to tune the resulting morphologies of AuNPs. With the ratio of MoS2/Thi decreasing, the shapes of AuNPs changed from spherical, triangle, clover-like to flower-like nanostructures. TEM, XRD and XPS were employed to characterize the formation and chemical composition of AuNP-Thi-MoS2 nanocomposites. On the basis of synthesis, a MoS2-based label-free electrochemical immunosensor had been designed to detect carcino-embryonic antigen (CEA). The proposed immunosensor could detect as low as 0.52 pg mL(-1) CEA with excellent selectivity. Moreover, the expected immunosensor showed high stability and excellent reproducibility, which could detect CEA in human serum with satisfactory results. Therefore, the AuNP-Thi-MoS2 nanocomposites may be considered as a candidate sensing platform for fabrication of simple, label-free and ultrasensitive electrochemical sensors.
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM), National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamssu@njupt.edu.cn iamlhwang@njupt.edu.cn.
authors.forename: Shao
authors.initials: S
authors.lastname: Su
authors.forename: Min
authors.initials: M
authors.lastname: Zou
authors.forename: He
authors.initials: H
authors.lastname: Zhao
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Yuan
authors.forename: Yanan
authors.initials: Y
authors.lastname: Xu
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
mesh_terms: D002272:Carcinoembryonic Antigen / Q000032:analysis* / Q000378:metabolism; D004220:Disulfides / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007118:Immunoassay; D053768:Metal Nanoparticles / Q000737:chemistry*; D008982:Molybdenum / Q000737:chemistry*; D010084:Oxidation-Reduction; D010640:Phenothiazines / Q000737:chemistry*
chemical_list: D002272:Carcinoembryonic Antigen; D004220:Disulfides; D010640:Phenothiazines; D006046:Gold; D008982:Molybdenum; C009469:thionine; C082964:molybdenum disulfide