title: The microbiome and its pharmacological targets: therapeutic avenues in cardiometabolic diseases.
abstract: Consisting of trillions of non-pathogenic bacteria living in a symbiotic relationship with their mammalian host, the gut microbiota has emerged in the past decades as one of the key drivers for cardiometabolic diseases (CMD). By degrading dietary substrates, the gut microbiota produces several metabolites that bind human pharmacological targets, impact subsequent signalling networks and in fine modulate host's metabolism. In this review, we revisit the pharmacological relevance of four classes of gut microbial metabolites in CMD: short-chain fatty acids (SCFA), bile acids, methylamines and indoles. Unravelling the signalling mechanisms of the microbial-mammalian metabolic axis adds one more layer of complexity to the physiopathology of CMD and opens new avenues for the development of microbiota-based pharmacological therapies.
authors.affiliation: Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
authors.forename: Ana Luisa
authors.initials: AL
authors.lastname: Neves
authors.affiliation: Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
authors.forename: Julien
authors.initials: J
authors.lastname: Chilloux
authors.affiliation: Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
authors.forename: Magali H
authors.initials: MH
authors.lastname: Sarafian
authors.affiliation: Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
authors.forename: Mohd Badrin Abdul
authors.initials: MB
authors.lastname: Rahim
authors.affiliation: Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
authors.forename: Claire L
authors.initials: CL
authors.lastname: Boulangé
authors.affiliation: Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, Exhibition Road, London SW7 2AZ, UK. Electronic address: m.dumas@imperial.ac.uk.
authors.forename: Marc-Emmanuel
authors.initials: ME
authors.lastname: Dumas
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D005232:Fatty Acids, Volatile / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007211:Indoles / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000178:diet therapy / Q000188:drug therapy* / Q000378:metabolism* / Q000382:microbiology; D008744:Methylamines / Q000378:metabolism*; D008954:Models, Biological; D056692:Prebiotics; D019936:Probiotics / Q000627:therapeutic use; D015398:Signal Transduction / Q000502:physiology
chemical_list: D001647:Bile Acids and Salts; D005232:Fatty Acids, Volatile; D007211:Indoles; D008744:Methylamines; D056692:Prebiotics
keywords: 3-indoxylsulfate (PubChem CID: 10258); Acetate (PubChem CID: 176); Butyrate (PubChem CID: 264); Chenodeoxycholic acid (PubChem CID: 10133); Cholic acid (PubChem CID: 221493); Deoxycholic acid (PubChem CID: 222528); Indole-3-propionate (PubChem CID: 3744); Propionate (PubChem CID: 1032); Trimethylamine (PubChem CID: 1146); Trimethylamine-N-oxide (PubChem CID: 1145)