title: A loopy view of telomere evolution.
abstract: About a decade ago, I proposed that t-loops, the lariat structures adopted by many eukaryotic telomeres, could explain how the transition from circular to linear chromosomes was successfully negotiated by early eukaryotes. Here I reconsider this loopy hypothesis in the context of the idea that eukaryotes evolved through a period of genome invasion by Group II introns.
authors.affiliation: Laboratory for Cell Biology and Genetics, The Rockefeller University , New York, NY, USA.
authors.forename: Titia
authors.initials: T
authors.lastname: de Lange
keywords: DNA damage; Group II intron; eukaryote; replication; telomerase; telomere