title: Defective nuclear entry of hydrolases prevents neutrophil extracellular trap formation in patients with chronic granulomatous disease.
authors.affiliation: Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland; Division of Immunology, University Children's Hospital Zurich and Children's Research Center, Zurich, Switzerland.
authors.forename: Susana
authors.initials: S
authors.lastname: Romao
authors.affiliation: Division of Immunology, University Children's Hospital Zurich and Children's Research Center, Zurich, Switzerland.
authors.forename: Emilio
authors.initials: E
authors.lastname: Tejera
authors.affiliation: Division of Immunology, University Children's Hospital Zurich and Children's Research Center, Zurich, Switzerland.
authors.forename: Katarzyna J
authors.initials: KJ
authors.lastname: Nytko
authors.affiliation: Division of Immunology, University Children's Hospital Zurich and Children's Research Center, Zurich, Switzerland.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Siler
authors.affiliation: Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Münz
authors.affiliation: Division of Immunology, University Children's Hospital Zurich and Children's Research Center, Zurich, Switzerland. Electronic address: janine.reichenbach@kispi.uzh.ch.
authors.forename: Janine
authors.initials: J
authors.lastname: Reichenbach
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000730:Androstadienes / Q000494:pharmacology; D001596:Benzylamines / Q000494:pharmacology; D002176:Candida albicans; D002467:Cell Nucleus / Q000276:immunology / Q000378:metabolism; D065206:Extracellular Traps; D006105:Granulomatous Disease, Chronic / Q000276:immunology* / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000276:immunology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011799:Quinazolines / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000276:immunology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D000077191:Wortmannin
chemical_list: D000225:Adenine; D000730:Androstadienes; D001596:Benzylamines; D006657:Histones; D006867:Hydrolases; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011799:Quinazolines; D017382:Reactive Oxygen Species; D013755:Tetradecanoylphorbol Acetate; D000077191:Wortmannin; C000591235:spautin-1; C025946:3-methyladenine