title: Primary HPV test screening in cervical cancer: a two-year experience of a single screening center in Latina (Italy).
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect and performance of the new algorithm in cervical cancer screening program in two years' experience of Latina (Italy). MATERIALS AND MTHODS: The female population was divided into two groups, the first group was referred to PAP test and the second one to hr-HPV test according to national guidelines.
  
  
  RESULTS
  In two years the participation mean rate increased among women aged 35-64 compared to women aged 25-34. The primary PAP test positive rate and hr-HPV test positive rate were 4.0% and 5.2%, respectively. The PAP test positive rate among hr-HPV+ women decreased from 2012 to 2013. Women with hr-HPV+/PAP+ were referred immediately to colposcopy and this rate was 1.2%. The predictive positive value for CIN2+ to colposcopy was 10.9% in 2012 and 9.1% in 2013, while the detection rate for CIN2+ was 1.6% in 2012 and 1.4% in 2013.
  
  
  CONCLUSIONS
  The stratification of the female population leads to a decreased inappropriate therapeutic path while the combination of hr-HPV test with PAP test in woman aged 35-64 lets obtain high levels specificity and sensitivity results.
authors.forename: C
authors.initials: C
authors.lastname: Chiappetta
authors.forename: E
authors.initials: E
authors.lastname: Lendaro
authors.forename: J
authors.initials: J
authors.lastname: Cacciotti
authors.forename: R
authors.initials: R
authors.lastname: Zaralli
authors.forename: C
authors.initials: C
authors.lastname: Puggioni
authors.forename: G
authors.initials: G
authors.lastname: Migliore
authors.forename: P
authors.initials: P
authors.lastname: Bellardini
authors.forename: N
authors.initials: N
authors.lastname: Porta
authors.forename: V
authors.initials: V
authors.lastname: Petrozza
authors.forename: C
authors.initials: C
authors.lastname: Della Rocca
authors.forename: C
authors.initials: C
authors.lastname: Di Cristofano
mesh_terms: D000328:Adult; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D007558:Italy; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000821:virology*