title: The influence of oxidative stress induced by iron on telomere length.
abstract: Oxidative stress can be induced by increased concentrations of iron in the body and consequently can cause shortening of telomeres. Telomeres, called mitotic clocks, are non-coding fragments at the end of chromosomes. During the replication of genetic material they are shortened, playing the role of ageing biomarkers in eukaryotes. In human endothelial cells, oxidative stress causes a decrease in telomerase activity. Shortening of chromosomes in telomeric parts was found in patients with primary hemochromatosis and in patients taking supplements containing iron. Increased level of transferrin saturation is associated with the presence of shorter telomeres in the chromosomes of leukocytes. The relationship between iron status and telomere length is still not fully understood.
authors.affiliation: Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland. Electronic address: zalewska.m@gmail.com.
authors.forename: Marta
authors.initials: M
authors.lastname: Kepinska
authors.affiliation: Students Scientific Society at the Department of Biomedical Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.
authors.forename: Jakub
authors.initials: J
authors.lastname: Szyller
authors.affiliation: Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.
authors.forename: Halina
authors.initials: H
authors.lastname: Milnerowicz
mesh_terms: D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006432:Hemochromatosis / Q000235:genetics; D006801:Humans; D007501:Iron / Q000009:adverse effects*; D018384:Oxidative Stress; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000187:drug effects*; D059506:Telomere Shortening; D014168:Transferrin / Q000378:metabolism
chemical_list: D014168:Transferrin; D007501:Iron; D019098:Telomerase
keywords: Iron; Oxidative stress; Telomere shortening