title: Pretreatment or Posttreatment with Aripiprazole Attenuates Methamphetamine-induced Stereotyped Behavior in Mice.
abstract: Aripiprazole is a third-generation atypical antipsychotic and a dopamine D2 receptor partial agonist. In the present study, we investigated whether a single administration of aripiprazole to mice, either as a pretreatment or as a posttreatment, would affect stereotypy induced by methamphetamine (METH). Pretreatment of male ICR mice with aripiprazole (1 or 10 mg/kg, i.p.) attenuated the incidence of METH-induced stereotypical behavior in a dose-dependent manner. Pretreatment of mice with 1 mg/kg aripiprazole produced an increase in the locomotor activity in mice treated with METH compared with mice treated with vehicle plus METH and with 10 mg/kg aripiprazole plus METH. This increase in locomotion is indicative of a rightward shift in the dose-response curve for METH, consistent with a shift in the type of stereotypical behavior observed from biting to sniffing. Aripiprazole posttreatment, after METH-induced stereotypical behavior, was fully expressed and also significantly attenuated overall stereotypy in an aripiprazole dose-dependent manner. These data suggest that the antagonism of METH effects by aripiprazole should be investigated as a potential treatment for acute METH overdose.
authors.affiliation: Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Nobue
authors.initials: N
authors.lastname: Kitanaka
authors.affiliation: Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Kitanaka
authors.affiliation: Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA.
authors.forename: F Scott
authors.initials: FS
authors.lastname: Hall
authors.affiliation: Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kayama
authors.affiliation: Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sugimori
authors.affiliation: Research Service, New Mexico VA Healthcare System, Albuquerque, NM, USA.
authors.forename: George R
authors.initials: GR
authors.lastname: Uhl
authors.affiliation: Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Motohiko
authors.initials: M
authors.lastname: Takemura
keywords: aripiprazole; dopamine receptor; methamphetamine; stereotyped behavior