title: [Granulomatous inflammation in the bed of resected cerebral cavernoma in a child, caused by a hemostatic agent].
abstract: The study presents a clinical observation of foreign body granuloma, which is rare productive inflammation, developed on treatment with a hemostatic material upon removal of cerebral cavernoma.
  
  
  
  A 4-year-old boy operated on for left parietal lobe cavernoma was diagnosed with a mass lesion during a follow-up MRI examination 4 months after surgery. The patient was re-operated in connection with suspected abscess formation. The pathological tissue was subjected to the histological and immunohistochemical examination.
  
  
  
  Inflammation was accompanied by the formation of foreign body granulomas, and, in some areas, had immune nature with signs of focal destructive vasculitis, delayed maturation of the granulation tissue, and disturbance of the current organization and encapsulation processes. It is worth noting that granulomatous inflammation around a hemostatic material in the brain has no specific features during introscopy and mimics an abscess or tumor recurrence.
  
  
  
  The use of hemostatic materials upon resection of cerebral cavernous malformations may cause formation of granuloma mimicking disease relapse or abscess in the long term period. To prevent granulomatous inflammation, removal of a hemostatic material, if possible, from the surgical field is recommended when reliable hemostasis is achieved.
authors.affiliation: Polenov Russian Research Neurosurgical Institute, St. Petersburg, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Khachatryan
authors.affiliation: Polenov Russian Research Neurosurgical Institute, St. Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kim
authors.affiliation: Polenov Russian Research Neurosurgical Institute, St. Petersburg, Russia.
authors.forename: K A
authors.initials: KA
authors.lastname: Samochernykh
authors.affiliation: Polenov Russian Research Neurosurgical Institute, St. Petersburg, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Sidorin
authors.affiliation: Polenov Russian Research Neurosurgical Institute, St. Petersburg, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Sokolova
authors.affiliation: Polenov Russian Research Neurosurgical Institute, St. Petersburg, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Don
authors.affiliation: Polenov Russian Research Neurosurgical Institute, St. Petersburg, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Ivanov
mesh_terms: D002675:Child, Preschool; D015745:Granuloma, Foreign-Body / Q000209:etiology* / Q000473:pathology; D020786:Hemangioma, Cavernous, Central Nervous System / Q000601:surgery*; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans; D008297:Male; D019635:Neurosurgical Procedures / Q000009:adverse effects; D010296:Parietal Lobe / Q000601:surgery
chemical_list: D006490:Hemostatics