title: Association between exonic polymorphism (rs629849, Gly1619Arg) of IGF2R gene and obesity in Korean population.
abstract: The aim of this study is to investigate the relationship between single nucleotide polymorphisms (SNPs) and susceptibility to obesity. A previous study suggested that insulin-like growth factors (IGFs) may affect obesity and that IGFs regulate cellular signals by receptors that include the insulin-like growth factor 1 receptor (IGF1R) and the insulin-like growth factor 2 receptor (IGF2R). In this research, the rs3743262 and rs2229765 SNPs of IGF1R gene and rs629849 and rs1805075 SNPs of IG-F2R gene were genotyped in 120 overweight and obese patients with a BMI≥23 kg/m2 (Body Mass Index) and 123 healthy controls with a BMI of 18.5-23.0 kg/m2. Genotyping of each SNP was performed by direct sequencing. Among tested SNPs in IGF1R and IGF2R genes, rs629849 SNP of IGF2R gene showed significant association with obesity (OR=1.86, 95% CI=1.02-3.40, P=0.044 in codominant1 model; OR=1.99, 95% CI=1.10-3.57, P=0.020 in dominant model; OR=1.93, 95% CI=1.13-3.31, P=0.013 in log-additive model). And allele distribution between the control group and overweight/obese group also showed significant difference (OR=1.93, 95% CI=1.14-3.28, P=0.015). In conclusion, these results indicate that rs629849 SNP of IGF2R might be contributed to development of obesity in the Korean population.
authors.affiliation: College of Nursing, Sungshin Women's University, Seoul, Korea.
authors.forename: Seung-Ae
authors.initials: SA
authors.lastname: Yang
keywords: IGF1R; IGF2R; Obesity; Overweight; Single nucleotide polymorphism