title: Palladium-Catalyzed Nucleophilic Substitution/C-H Activation/Aromatization Cascade Reaction: One Approach To Construct 6-Unsubstituted Phenanthridines.
abstract: A facile and practical palladium-catalyzed nucleophilic substitution/C-H activation/aromatization cascade reaction has been developed. A range of 6-unsubstituted phenanthridines could be obtained in moderate to good yields (31-85%) with readily prepared N-Ms arylamines and commercially available 2-bromobenzyl bromide derivatives as starting materials. The potential application of the protocol was also demonstrated by the expeditious synthesis of the natural alkaloid trisphaeridine.
authors.affiliation: School of Pharmacy, Zunyi Medical University , Zunyi, 563000, P. R. China.
authors.forename: Wenyong
authors.initials: W
authors.lastname: Han
authors.affiliation: School of Pharmacy, Zunyi Medical University , Zunyi, 563000, P. R. China.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Zhou
authors.affiliation: School of Pharmacy, Zunyi Medical University , Zunyi, 563000, P. R. China.
authors.forename: Siyi
authors.initials: S
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Zunyi Medical University , Zunyi, 563000, P. R. China.
authors.forename: Guangyan
authors.initials: G
authors.lastname: Xiang
authors.affiliation: School of Pharmacy, Zunyi Medical University , Zunyi, 563000, P. R. China.
authors.forename: Baodong
authors.initials: B
authors.lastname: Cui
authors.affiliation: School of Pharmacy, Zunyi Medical University , Zunyi, 563000, P. R. China.
authors.forename: Yongzheng
authors.initials: Y
authors.lastname: Chen