title: Parameters of Pro- and Antioxidant Status in Ejaculate of Men of Fertile Age.
abstract: Parameters of LPO reflecting primary and end stages of oxidation and total antioxidant activity were evaluated in the seminal fluid of young fertile men living in Novosibirsk. By the results of andrological examination and spermogram analysis, various reproductive disorders and abnormal spermogram (pathospermia) were found in 48 patients. Shifts towards activation of prooxidant processes in LPO-antioxidant defense metabolic system were observed in men with reproductive disorders and pathospermia. The results of individual estimation of coefficient of oxidative stress, an integral parameter reflecting the balance in the LPO-antioxidant defense system, attest to the development of oxidative stress in men with reproductive disorders and pathospermia.
authors.affiliation: Research Center of Health Problems of Family and Human Reproduction, Irkutsk, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Kolesnikova
authors.affiliation: Research Center of Health Problems of Family and Human Reproduction, Irkutsk, Russia. nakurashova@yandex.ru.
authors.forename: N A
authors.initials: NA
authors.lastname: Kurashova
authors.affiliation: Institute of Cytology and Genetic, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Osadchuk
authors.affiliation: Institute of Cytology and Genetic, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Osadchuk
authors.affiliation: Research Center of Health Problems of Family and Human Reproduction, Irkutsk, Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Dolgikh
authors.affiliation: Republican Perinatal Center, Ministry of Healthcare of the Russian Federation, Ulan-Ude, Republic of Buryatia, Russia.
authors.forename: B G
authors.initials: BG
authors.lastname: Dashiev
mesh_terms: D000328:Adult; D000367:Age Factors; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D004542:Ejaculation; D005298:Fertility / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D012661:Semen / Q000737:chemistry / Q000378:metabolism*; D055101:Semen Analysis
chemical_list: D000975:Antioxidants; D016877:Oxidants
keywords: antioxidants; lipid peroxidation; men; seminal fluid; spermatogenesis