title: Differences in intestinal metaplasia in Barrett's esophagus patients in an ethnically diverse south London population.
abstract: Barrett's esophagus (BE) is the replacement of any portion of the normal distal squamous epithelial mucosa by metaplastic columnar epithelium and is the only known precursor for esophageal adenocarcinoma. We undertook a study to identify ethnic differences for the presence of intestinal metaplasia (IM) in BE in patients in an ethnically diverse south London population. Retrospective analysis was done using the endoscopy database of St George's Hospital NHS Trust, which serves a large ethnically diverse London population. Gastroscopy records between 2009 and 2012 were retrieved, and patients with an endoscopic diagnosis of BE were identified. Patients of Indian subcontinent Asian origin (ISCA) were further identified. The presence of IM was retrieved from hospital pathology databases and was the primary outcome measured. Multivariate logistic regression analysis was performed to determine the odds of having IM by ethnic origin. ISCAs were 70% less likely to have IM compared to non-ISCAs (OR 0.32, 95% CI: 0.16-0.61, p = 0.001). This is the first study to identify differences in histological findings in ISCAs with BE living in the UK. Our findings may be useful for the future risk stratification of BE patients. Identification of environmental factors responsible for this difference would be of great therapeutic value.
authors.affiliation: Department of Gastroenterology, St George's Hospital NHS Trust, Blackshaw Road, London, SW17 0QT, UK. rhyshewett@doctors.net.uk.
authors.forename: Rhys
authors.initials: R
authors.lastname: Hewett
authors.affiliation: Department of Gastroenterology, St George's Hospital NHS Trust, Blackshaw Road, London, SW17 0QT, UK.
authors.forename: Vivek
authors.initials: V
authors.lastname: Chhaya
authors.affiliation: Department of Gastroenterology, St George's Hospital NHS Trust, Blackshaw Road, London, SW17 0QT, UK.
authors.forename: Derek
authors.initials: D
authors.lastname: Chan
authors.affiliation: Department of Gastroenterology, St George's Hospital NHS Trust, Blackshaw Road, London, SW17 0QT, UK.
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Kang
authors.affiliation: Department of Gastroenterology, St George's Hospital NHS Trust, Blackshaw Road, London, SW17 0QT, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Poullis
mesh_terms: D000368:Aged; D001471:Barrett Esophagus / Q000208:ethnology* / Q000473:pathology*; D005260:Female; D005773:Gastroscopy; D006801:Humans; D007194:India / Q000208:ethnology; D007422:Intestines / Q000473:pathology*; D016015:Logistic Models; D008131:London; D008297:Male; D008679:Metaplasia / Q000208:ethnology; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012306:Risk
keywords: Barrett’s esophagus; Endoscopy; Ethnicity; Intestinal metaplasia; Risk stratification