title: Molecular Mechanisms and Novel Therapeutic Approaches to Rhabdomyolysis-Induced Acute Kidney Injury.
abstract: Rhabdomyolysis is a syndrome caused by injury to skeletal muscle that usually leads to acute kidney injury (AKI). Rhabdomyolysis has been linked to different conditions, including severe trauma and intense physical exercise. Myoglobin-induced renal toxicity plays a key role in rhabdomyolysis-associated kidney damage by increasing oxidative stress, inflammation, endothelial dysfunction, vasoconstriction, and apoptosis. New drugs that target the harmful effects of myoglobin have been recently developed, and some have been proven to be successful in animal models of acute renal failure secondary to rhabdomyolysis. This review aims to provide a comprehensive and updated overview of the pathological mechanisms of renal damage and describes new therapeutic approaches to this condition based on novel compounds that target key pathways involved in myoglobin-mediated kidney damage.
authors.affiliation: Nefrovall, B-BRAUN Avitum. La Vall d' Uixx00F3;, Castellx00F3;n, Spain.
authors.forename: Nayara
authors.initials: N
authors.lastname: Panizo
authors.forename: Alfonso
authors.initials: A
authors.lastname: Rubio-Navarro
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Amaro-Villalobos
authors.forename: Jesús
authors.initials: J
authors.lastname: Egido
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Moreno
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007502:Iron Chelating Agents / Q000494:pharmacology / Q000627:therapeutic use; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D009211:Myoglobin / Q000037:antagonists & inhibitors / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D012206:Rhabdomyolysis / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D007502:Iron Chelating Agents; D009211:Myoglobin