title: [Test of Serum Free Light Chain and Its Clinical Significance in Light Chain Multiple Myeloma].
abstract: OBJECTIVE
  To investigate the clinical significance of serum free light chain (sFLC) detection in light chain multiple myeloma (LCMM).
  
  
  METHODS
  A total of 37 newly diagnosed LCMM patients were enrolled in this study, including 17 patients with k light chain type and 20 patients with λ light chain type, the sFLC and 24 hours urine light chain (ULC) were measured before and after chemotherapy. The correlation of sFLC level with ULC and renal impairment was analyzed.
  
  
  RESULTS
  All the patients displayed an abnormally increased level of sFLC at diagnosis wtih median value of 105.44 mg/L and 146.39 mg/L for k and λ light chain types, respectively. The sFLC did not correlate with ULC before and after chemotherapy. Among the 12 patients with very good partial remission and normal ULC level, the sFLC still was abnormally increased in 8 patients. Renal impairment was associated with the urine λ-type light chain, and the area under the ROC curve of urine λ light chain at diagnosis is 0.792 (P = 0.031).
  
  
  CONCLUSIONS
  All patients with LCMM show an abnormally increased level of sFLC at diagnosis. sFLC can be used to monitor the response to chemotherapy because it is more sensitive for analysis of therapeutic effect than urine λ light chain.
authors.affiliation: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, Chinese PLA, Nanjing 210002, Jiangsu Province, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Song
authors.affiliation: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, Chinese PLA, Nanjing 210002, Jiangsu Province, China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: An
authors.affiliation: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, Chinese PLA, Nanjing 210002, Jiangsu Province, China.
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Zhou
authors.affiliation: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, Chinese PLA, Nanjing 210002, Jiangsu Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, Chinese PLA, Nanjing 210002, Jiangsu Province, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Wang
authors.affiliation: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, Chinese PLA, Nanjing 210002, Jiangsu Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, Chinese PLA, Nanjing 210002, Jiangsu Province, China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Yu
authors.affiliation: Department of Hematology, Nanjing General Hospital of Nanjing Military Command, Chinese PLA, Nanjing 210002, Jiangsu Province, China. E-mail: ypzhaicn@yahoo.com.cn.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Zhai
mesh_terms: D006801:Humans; D007147:Immunoglobulin Light Chains / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000097:blood; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy; D051437:Renal Insufficiency
chemical_list: D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains