title: Ensuring Sample Quality for Biomarker Discovery Studies - Use of ICT Tools to Trace Biosample Life-cycle.
abstract: The growing demand of personalized medicine marked the transition from an empirical medicine to a molecular one, aimed at predicting safer and more effective medical treatment for every patient, while minimizing adverse effects. This passage has emphasized the importance of biomarker discovery studies, and has led sample availability to assume a crucial role in biomedical research. Accordingly, a great interest in Biological Bank science has grown concomitantly. In biobanks, biological material and its accompanying data are collected, handled and stored in accordance with standard operating procedures (SOPs) and existing legislation. Sample quality is ensured by adherence to SOPs and sample whole life-cycle can be recorded by innovative tracking systems employing information technology (IT) tools for monitoring storage conditions and characterization of vast amount of data. All the above will ensure proper sample exchangeability among research facilities and will represent the starting point of all future personalized medicine-based clinical trials.
authors.affiliation: BioBIM - Multidisciplinary Interinstitutional BioBank, IRCCS San Raffaele Pisana - Research Center, Rome, Italy Medical Oncology, Policlinico Tor Vergata Biospecimen Cancer Biorepository (IIV Bio. Ca. Re), Department of Internal Medicine, University of Rome "Tor Vergata", Tor Vergata Clinical Center, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Riondino
authors.affiliation: San Raffaele Rome University, IRCCS San Raffaele Pisana, Research Center, Rome, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Ferroni
authors.affiliation: BioBIM - Multidisciplinary Interinstitutional BioBank, IRCCS San Raffaele Pisana - Research Center, Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Spila
authors.affiliation: BioBIM - Multidisciplinary Interinstitutional BioBank, IRCCS San Raffaele Pisana - Research Center, Rome, Italy.
authors.forename: Jhessica
authors.initials: J
authors.lastname: Alessandroni
authors.affiliation: BioBIM - Multidisciplinary Interinstitutional BioBank, IRCCS San Raffaele Pisana - Research Center, Rome, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: D'Alessandro
authors.affiliation: Medical Oncology, Policlinico Tor Vergata Biospecimen Cancer Biorepository (IIV Bio. Ca. Re), Department of Internal Medicine, University of Rome "Tor Vergata", Tor Vergata Clinical Center, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Formica
authors.affiliation: BioBIM - Multidisciplinary Interinstitutional BioBank, IRCCS San Raffaele Pisana - Research Center, Rome, Italy Medical Oncology, Policlinico Tor Vergata Biospecimen Cancer Biorepository (IIV Bio. Ca. Re), Department of Internal Medicine, University of Rome "Tor Vergata", Tor Vergata Clinical Center, Rome, Italy.
authors.forename: David
authors.initials: D
authors.lastname: Della-Morte
authors.affiliation: San Raffaele Rome University, IRCCS San Raffaele Pisana, Research Center, Rome, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Palmirotta
authors.affiliation: Department of Computer, Control and Management Engineering "Antonio Ruberti", "Sapienza" University, Rome, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Nanni
authors.affiliation: Medical Oncology, Policlinico Tor Vergata Biospecimen Cancer Biorepository (IIV Bio. Ca. Re), Department of Internal Medicine, University of Rome "Tor Vergata", Tor Vergata Clinical Center, Rome, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Roselli
authors.affiliation: BioBIM - Multidisciplinary Interinstitutional BioBank, IRCCS San Raffaele Pisana - Research Center, Rome, Italy San Raffaele Rome University, IRCCS San Raffaele Pisana, Research Center, Rome, Italy fiorella.guadagni@sanraffaele.it.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Guadagni
mesh_terms: D018070:Biological Specimen Banks / Q000592:standards; D015415:Biomarkers / Q000032:analysis*; D002986:Clinical Trials as Topic / Q000592:standards; D019295:Computational Biology / Q000592:standards*; D016208:Databases, Factual; D020869:Gene Expression Profiling; D019983:Guideline Adherence; D006801:Humans; D062346:Molecular Medicine / Q000592:standards; D009369:Neoplasms / Q000628:therapy; D057285:Precision Medicine / Q000592:standards*; D011379:Prognosis; D011788:Quality of Life; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers
keywords: Biomarker discovery; ICT tools; biobanking; review; sample quality