title: Metal-free tandem oxidative C(sp(3))-H bond functionalization of alkanes and dearomatization of N-phenyl-cinnamamides: access to alkylated 1-azaspiro[4.5]decanes.
abstract: The TBPB promoted tandem oxidative C(sp(3))-H bond functionalization of simple alkanes/alkylation-initiated dearomatization of N-phenyl-cinnamamides is reported, providing a direct method for the synthesis of alkylated 1-azaspiro[4.5]decanes with excellent regioselectivity and diastereoselectivity. The formation of two C(sp(3))-C(sp(3)) bonds and construction of a spirodienone motif are involved in one step.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. cjzhu@nju.edu.cn.
authors.forename: Honglin
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhangxi
authors.initials: Z
authors.lastname: Gu
authors.forename: Pan
authors.initials: P
authors.lastname: Xu
authors.forename: Hongwen
authors.initials: H
authors.lastname: Hu
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu