title: Biocompatible and biodegradable poly(Tannic Acid) hydrogel with antimicrobial and antioxidant properties.
abstract: A novel resourceful bulk poly(Tannic Acid) (p(TA)) hydrogel was prepared by crosslinking TA molecules with an epoxy crosslinker, trimethylolpropane triglycidyl ether (TMPGDE), in an autoclave at 90°C for 2h. The obtained p(TA) hydrogels were in disk form and have highly porous morphology. The swelling characteristics of p(TA) hydrogels were investigated in wound healing pH conditions of pH 5.4, 7.4, and 9 at 37.5°C, and the hydrogels showed good swelling and moisture content behavior. Especially, p(TA) hydrogels were found to be sensitive to pH 9 with 1669% maximum swelling. P(TA) hydrogels were completely degraded at pH 9 hydrolytically in 9 days. Total phenol contents and the effects of scavenging ABTS(+) radicals of degraded p(TA) hydrogels at pH 5.4, 7.4, and 9 were evaluated and calculated in terms of gallic acid equivalent and trolox equivalent antioxidant capacity, respectively, and found to be very effective. Moreover, degraded p(TA) hydrogels display strong antimicrobial behavior against gram positive Staphylococcus aureus, Bacillus subtilis, gram negative Pseudomonas aeruginosa bacteria strains and Candida albicans fungus strain. The WST-1 results indicated that bulk p(TA) hydrogels have no cyctotoxicity to the L929 fibroblast cell line in vitro.
authors.affiliation: Faculty of Science & Arts, Chemistry Department, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey; Nanoscience and Technology Research and Application Center (NANORAC), Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey. Electronic address: sahiner71@gmail.com.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Sahiner
authors.affiliation: Faculty of Science & Arts, Chemistry Department, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.
authors.forename: Selin
authors.initials: S
authors.lastname: Sagbas
authors.affiliation: Ege University, Engineering Faculty, Leather Engineering Department, Bornova, 35100 Izmir, Turkey.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Sahiner
authors.affiliation: School of Medicine, Department Pharmacology, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.
authors.forename: Coskun
authors.initials: C
authors.lastname: Silan
authors.affiliation: Chemical Engineering Department, Yuzuncu Yil University, Campus, Van 65080, Turkey.
authors.forename: Nahit
authors.initials: N
authors.lastname: Aktas
authors.affiliation: Bioengineering Department, Engineering Faculty, Kirikkale University, Yahsihan, Kırıkkale 71450, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Turk
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D001704:Biopolymers / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry*; D006868:Hydrolysis; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D013634:Tannins / Q000737:chemistry*; D013818:Thermogravimetry
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D001672:Biocompatible Materials; D001704:Biopolymers; D013634:Tannins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: Antimicrobial/antioxidant hydrogel; Biodegradable/biocompatible superporous film; Tannic acid