title: [DEVELOPMENT PROGRESS OF MESENCHYMAL STEM CELLS SENESCENCE].
abstract: OBJECTIVE
  TO summarize the researcn situation or mesenchymal stem cells (MSCs) senescence, including the characteristics and mechanisms of senescence.
  
  
  METHODS
  The original articles in recent years about MSCs senescence were extensively reviewed, and comprehensively analyzed.
  
  
  RESULTS
  The senescence of MSCs which manifests as morphological senescence, reduced proliferation and differentiation potential, altered immunoregulation are found during the cultivation in experiment, which profoundly affects clinical application of MSCs. The research about the mechanisms of MSCs senescence includes telomere and telomerase, and stress-mediated injury etc, involving regulation of telomerase, and regulation of signal pathways of p53/p21, P13K/Akt, and Wnt/β-catenin etc.
  
  
  CONCLUSIONS
  The further study of senescence mechanisms will help to accelerate the clinical application of MSCs in the future.
authors.forename: Houyi
authors.initials: H
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Yuntao
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000375:Aging; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D016922:Cellular Senescence; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D018384:Oxidative Stress; D015398:Signal Transduction; D019098:Telomerase / Q000378:metabolism*; D023822:Tissue Engineering / Q000639:trends*; D051176:beta Catenin
chemical_list: D051176:beta Catenin; D019098:Telomerase