title: The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases.
abstract: Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank.
authors.affiliation: Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center , Maastricht , Netherlands.
authors.forename: Babette L R
authors.initials: BL
authors.lastname: Reijs
authors.affiliation: Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, VU University Medical Center , Amsterdam , Netherlands.
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: Teunissen
authors.affiliation: Integrated Biobank of Luxembourg , Luxembourg , Luxembourg.
authors.forename: Nikolai
authors.initials: N
authors.lastname: Goncharenko
authors.affiliation: Integrated Biobank of Luxembourg , Luxembourg , Luxembourg.
authors.forename: Fay
authors.initials: F
authors.lastname: Betsou
authors.affiliation: Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, The Sahlgrenska Academy at University of Gothenburg , Mölndal , Sweden.
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.affiliation: Center for Neuroscience and Cell Biology, Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra , Coimbra , Portugal.
authors.forename: Inês
authors.initials: I
authors.lastname: Baldeiras
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE) e.V. Clinical Neuroscience and Biomarkers , Bonn , Germany.
authors.forename: Frederic
authors.initials: F
authors.lastname: Brosseron
authors.affiliation: Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Fatebenefratelli , Brescia , Italy.
authors.forename: Enrica
authors.initials: E
authors.lastname: Cavedo
authors.affiliation: Department of Neurology, Akershus University Hospital , Lørenskog , Norway ; Institute of Clinical Medicine, University of Oslo , Oslo , Norway.
authors.forename: Tormod
authors.initials: T
authors.lastname: Fladby
authors.affiliation: Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg , Mannheim , Germany.
authors.forename: Lutz
authors.initials: L
authors.lastname: Froelich
authors.affiliation: Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences , Warsaw , Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gabryelewicz
authors.affiliation: Behavioural Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University , Istanbul , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Gurvit
authors.affiliation: Neurochemistry Unit, Division of Cognitive and Movement Disorders, 1st Department of Neurology, National and Kapodistrian University of Athens , Athens , Greece.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Kapaki
authors.affiliation: Department of Neurology, Slovak Medical University, University Hospital Bratislava , Bratislava , Slovakia ; Institute of Neuroimmunology, Slovak Academy of Sciences , Bratislava , Slovakia.
authors.forename: Peter
authors.initials: P
authors.lastname: Koson
authors.affiliation: Division of Psychiatry Research, University of Zurich , Schlieren , Switzerland.
authors.forename: Luka
authors.initials: L
authors.lastname: Kulic
authors.affiliation: Laboratoire de Biochimie Protéomique Clinique, INSERM U1183, Institut de Médecine Régénérative et Biothérapies, CHRU de Montpellier, Université de Montpellier , Montpellier , France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lehmann
authors.affiliation: Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany ; Department of Neurodegeneration Diagnostics, Medical University of Bialystok , Bialystok , Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewczuk
authors.affiliation: Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Sant Pau , Barcelona , Spain ; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) , Madrid , Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Lleó
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen , Tübingen , Germany ; German Center for Neurodegenerative Diseases (DZNE), University of Tübingen , Tübingen , Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
authors.affiliation: Faculty of Medicine, University of Lisbon , Lisbon , Portugal.
authors.forename: Alexandre
authors.initials: A
authors.lastname: de Mendonça
authors.affiliation: Medical Gerontology, School of Medicine, Trinity College Dublin , Dublin , Ireland.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Miller
authors.affiliation: ICN Hospital Clinic i Universitari, Institut d'Investigacions Biomèdiques August Pi i Sunyer , Barcelona , Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Molinuevo
authors.affiliation: Paracelsus-Elena-Klinik , Kassel , Germany ; Department of Neurosurgery and Institute of Neuropathology, University Medical Center Göttingen , Göttingen , Germany.
authors.forename: Brit
authors.initials: B
authors.lastname: Mollenhauer
authors.affiliation: Section of Neurology, Centre for Memory Disturbances, University of Perugia , Perugia , Italy.
authors.forename: Lucilla
authors.initials: L
authors.lastname: Parnetti
authors.affiliation: Laboratory for CSF Diagnostics, Department of Neurology, University Medical Centre , Ljubljana , Slovenia.
authors.forename: Uros
authors.initials: U
authors.lastname: Rot
authors.affiliation: Department of Psychiatry and Psychotherapy, University Medical Center Göttingen and Translational Dementia Research Group, German Center for Neurodegenerative Diseases (DZNE) , Göttingen , Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Schneider
authors.affiliation: Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen , Denmark.
authors.forename: Anja Hviid
authors.initials: AH
authors.lastname: Simonsen
authors.affiliation: Unit of Neuropathology, Department of Diagnostics and Technology, IRCCS Foundation "Carlo Besta" Neurological Institute , Milan , Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Tagliavini
authors.affiliation: 3rd Department of Neurology, Aristotle University of Thessaloniki , Thessaloniki , Greece.
authors.forename: Magda
authors.initials: M
authors.lastname: Tsolaki
authors.affiliation: Department of Neurology, Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre , Nijmegen , Netherlands ; Department of Laboratory Medicine, Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre , Nijmegen , Netherlands.
authors.forename: Marcel M
authors.initials: MM
authors.lastname: Verbeek
authors.affiliation: Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center , Maastricht , Netherlands.
authors.forename: Frans R J
authors.initials: FR
authors.lastname: Verhey
authors.affiliation: Research-Scientific-Didactic Centre of Dementia-Related Diseases, Wrocław Medical University , Scinawa , Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Zboch
authors.affiliation: Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet , Huddinge , Sweden.
authors.forename: Bengt
authors.initials: B
authors.lastname: Winblad
authors.affiliation: Department of Neurology, Alzheimer Center, VU University Medical Center , Amsterdam , Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.affiliation: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg , Mölndal , Sweden ; UCL Institute of Neurology , London , UK.
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.affiliation: Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center , Maastricht , Netherlands ; Department of Neurology, Alzheimer Center, VU University Medical Center , Amsterdam , Netherlands.
authors.forename: Pieter Jelle
authors.initials: PJ
authors.lastname: Visser
keywords: Alzheimer’s disease; Parkinson’s disease; biobank; body fluids; cerebrospinal fluid; dementia; neurodegenerative disorders