title: Instructable Nanoparticles Using Dynamic Combinatorial Chemistry.
abstract: The application of nanoparticles to the multivalent recognition of biomacromolecules or programmed self-assembly requires control over the relative placement of chemical groups on their surface. We have developed a method to direct the functionalization of surfaces of aldehyde-equipped gold nanoparticles using a DNA template. An error-correction mechanism is built into the functionalization process thanks to the thermodynamic control enabled by the hydrazone exchange reaction. This reversible reaction can be conveniently switched off by removing the catalyst, preserving the functionalization.
authors.affiliation: Centre for Systems Chemistry, Stratingh Institute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.affiliation: Centre for Systems Chemistry, Stratingh Institute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Piotr
authors.initials: P
authors.lastname: Nowak
authors.affiliation: Centre for Systems Chemistry, Stratingh Institute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Colomb-Delsuc
authors.affiliation: Centre for Systems Chemistry, Stratingh Institute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Manuel Pernia
authors.initials: MP
authors.lastname: Leal
authors.affiliation: Centre for Systems Chemistry, Stratingh Institute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Sijbren
authors.initials: S
authors.lastname: Otto