title: ent-Kaurene Glycosides from Ageratina cylindrica.
abstract: The aqueous extract of the leaves of Ageratina cylindrica afforded six new ent-kaurenoic acid glycosides together with the known diterpenoid paniculoside V, the flavonoid astragalin, chlorogenic acid, and L-chiro-inositol. The structures were elucidated mainly by NMR and MS methods, and the absolute configuration was established by vibrational circular dichroism spectroscopy. The new compounds showed moderate antiprotozoal activity against Entamoeba histolytica and Giardia lamblia trophozoites.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , México, D.F. 04510, México.
authors.forename: Celia
authors.initials: C
authors.lastname: Bustos-Brito
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , México, D.F. 04510, México.
authors.forename: Mariano
authors.initials: M
authors.lastname: Sánchez-Castellanos
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , México, D.F. 04510, México.
authors.forename: Baldomero
authors.initials: B
authors.lastname: Esquivel
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , México, D.F. 04510, México.
authors.forename: José S
authors.initials: JS
authors.lastname: Calderón
authors.affiliation: Unidad de Investigación Médica en Farmacología, 2° Piso CORCE, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS , Avenida Cuauhtémoc 330, Col. Doctores, México, D.F. 06725, México.
authors.forename: Fernando
authors.initials: F
authors.lastname: Calzada
authors.affiliation: Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS , Avenida Cuauhtémoc 330, Col. Doctores, México, D.F. 06725, México.
authors.forename: Lilian
authors.initials: L
authors.lastname: Yépez-Mulia
authors.affiliation: Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional , Apartado 14-740, México, D.F. 07000, México.
authors.forename: Pedro
authors.initials: P
authors.lastname: Joseph-Nathan
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , México, D.F. 04510, México.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Cuevas
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria , México, D.F. 04510, México.
authors.forename: Leovigildo
authors.initials: L
authors.lastname: Quijano
mesh_terms: D036603:Ageratina / Q000737:chemistry*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004224:Diterpenes; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004748:Entamoeba histolytica / Q000187:drug effects; D016829:Giardia lamblia / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D018515:Plant Leaves / Q000187:drug effects; D053058:Trophozoites / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D006027:Glycosides; D044949:Kaempferols; C002627:kaurene; C051436:kaurenoic acid; C001579:astragalin