title: [Analysis of Megakaryocytes and Platelet Parameters of ITP Patients].
abstract: OBJECTIVE
  To investigate the value of bone marrow megakaryocyte (BMK) and peripheral platelet parameter changes in differential diagnosis of idiopathic thrombocytopenic purpura (ITP).
  
  
  METHODS
  The 91 patients were divided into 2 groups: ITP group (46 cases) and non-ITP group (45 cases), while 48 healthy volunteers were used as healthy controls. The parameters of BMK and peripheral platelets of ITP and non-ITP patients, and parameters of peripheral platelets of healthy controls were detected and compared.
  
  
  RESULTS
  As compared with non-ITP group, the BMK count in ITP group obviously increased, including the gramlar MK and proo-MK, while the MK producing platelets obviously dicreased with statistical difference (P < 0.01); the platelet parameters in 2 groups did not show significant difference (P > 0.05). As compared with healthy control group, the platelet level and PCT of peripheral blood in ITP group significantly decreased (P < 0.01).
  
  
  CONCLUSIONS
  The BMK level and platelet parameters, especially the platelet count and PCT have clinical value for differential diagnosis of ITP to a certain degree.
authors.affiliation: Department of Laboratorial Examination, Kaifeng Municipal Hospital of Traditioncal Chinese Medicine, Kaifeng 475000, Henan Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Laboratorial Examination, Maternal and Child Health Hospital of Dongguan City, Dongguan 523000, Guangdong Province, China. E-mail: liuliang71215@163.com.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Liu
mesh_terms: D001792:Blood Platelets; D001854:Bone Marrow Cells; D016022:Case-Control Studies; D002452:Cell Count; D003937:Diagnosis, Differential; D006801:Humans; D008533:Megakaryocytes; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis*