title: The Influence of Root-End Filling Materials on Bone Healing - An Experimental Study.
abstract: OBJECTIVE
  The aim of this experimental study is to assess the bone healing phenomenon produced in the presence of several dental materials: a polycarboxylate cement, a glass-ionomer cement, a composite resin and MTA (mineral trioxide aggregate) based cement.
  
  
  METHODS
  The biocompatibility of four root-end fillings materials, used in periapical surgery was investigated after intra-osseous implantation of the materials in rats' calvaria. Tissue reaction was studied at 2, 4, 6, 8, 10 and 12 weeks after implantation. We took into consideration the presence of inflammatory cells (polymorphonuclear leukocytes, macrophages, plasma cells, lymphocytes and giant cells) and classified the aspects of the histological samples according to the following scale: 0 - no inflammation, 1 - mild, isolated inflammation, 2 - moderate, localized inflammatory reaction, 3 - severe, diffuse and intense inflammatory reaction.
  
  
  RESULTS
  The inflammatory reaction was present at the six intervals for all the tested materials, but at 12 week interval, the reaction was minimal in all cases. Also, a dissolution reaction was observed for all the materials, less intense for glass-ionomer cement and polycarboxilate cement.
  
  
  CONCLUSIONS
  At the end of the experimental period, glass-ionomer cement and polycarboxilate cement suffered a lesser dissolution reaction as compared to the second group of tested materials.
authors.affiliation: Department of Prosthodontics, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
authors.forename: Andreea Gulie
authors.initials: AG
authors.lastname: Kui
authors.affiliation: Department of Prosthodontics, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
authors.forename: Antonela
authors.initials: A
authors.lastname: Berar
authors.affiliation: Department of Prosthodontics, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
authors.forename: Liana
authors.initials: L
authors.lastname: Lascu
authors.affiliation: Pathology Department, University of Agricultural Sciences and Veterinary Medicine, Cluj Napoca, Romania ; Department of Biomedical Sciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, St. Kitts and Nevis Federation, West Indies.
authors.forename: Pompei
authors.initials: P
authors.lastname: Bolfa
authors.affiliation: Department of Histology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
authors.forename: Bianca
authors.initials: B
authors.lastname: Bosca
authors.affiliation: Department of Histology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
authors.forename: Carmen
authors.initials: C
authors.lastname: Mihu
authors.affiliation: Department of Surgery and Implantology, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Baciut
authors.affiliation: Department of Dental Prevention, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
authors.forename: Ramona
authors.initials: R
authors.lastname: Avram
authors.affiliation: Department of Dental Prevention, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.
authors.forename: Mândra
authors.initials: M
authors.lastname: Badea
keywords: MTA; composite resin; inflammation; polycarboxilate cement; root-end filling material