title: Total Synthesis and Determination of the Absolute Configuration of Vinylamycin.
abstract: The absolute configurations of the three unknown chiral centers in vinylamycin were predicted according to the structural comparison with microtermolide A and rakicidin A, and then total syntheses of vinylamycin were applied to determine the three unknown chiral centers as 14R, 15R, and 16S.
authors.affiliation: The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Zhantao
authors.initials: Z
authors.lastname: Yang
authors.affiliation: The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Meiyan
authors.initials: M
authors.lastname: Ma
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin, 300072, People's Republic of China.
authors.forename: Jiangnan
authors.initials: J
authors.lastname: Li
authors.affiliation: The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Liu
authors.affiliation: The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Jinghan
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin, 300072, People's Republic of China.
authors.forename: Shende
authors.initials: S
authors.lastname: Jiang
authors.affiliation: The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
mesh_terms: D001426:Bacterial Proteins / Q000138:chemical synthesis* / Q000737:chemistry*; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D055666:Lipopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001426:Bacterial Proteins; D047630:Depsipeptides; D055666:Lipopeptides; D010456:Peptides, Cyclic; C574709:microtermolide A; C402693:vinylamycin; C000723972:rakicidins