title: Yellow fever impact on brown howler monkeys (Alouatta guariba clamitans) in Argentina: a metamodelling approach based on population viability analysis and epidemiological dynamics.
abstract: In South America, yellow fever (YF) is an established infectious disease that has been identified outside of its traditional endemic areas, affecting human and nonhuman primate (NHP) populations. In the epidemics that occurred in Argentina between 2007-2009, several outbreaks affecting humans and howler monkeys (Alouatta spp) were reported, highlighting the importance of this disease in the context of conservation medicine and public health policies. Considering the lack of information about YF dynamics in New World NHP, our main goal was to apply modelling tools to better understand YF transmission dynamics among endangered brown howler monkey (Alouatta guariba clamitans) populations in northeastern Argentina. Two complementary modelling tools were used to evaluate brown howler population dynamics in the presence of the disease: Vortex, a stochastic demographic simulation model, and Outbreak, a stochastic disease epidemiology simulation. The baseline model of YF disease epidemiology predicted a very high probability of population decline over the next 100 years. We believe the modelling approach discussed here is a reasonable description of the disease and its effects on the howler monkey population and can be useful to support evidence-based decision-making to guide actions at a regional level.
authors.affiliation: Universidade Federal do Oeste do Pará, Santarém, PA, Brasil.
authors.forename: Eduardo S
authors.initials: ES
authors.lastname: Moreno
authors.affiliation: Instituto de Biología Subtropical, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Misiones, Puerto Iguazú, Misiones, Argentina.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Agostini
authors.affiliation: Instituto de Biología Subtropical, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Misiones, Puerto Iguazú, Misiones, Argentina.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Holzmann
authors.affiliation: Instituto de Biología Subtropical, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Misiones, Puerto Iguazú, Misiones, Argentina.
authors.forename: Mario S
authors.initials: MS
authors.lastname: Di Bitetti
authors.affiliation: Instituto de Biología Subtropical, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Misiones, Puerto Iguazú, Misiones, Argentina.
authors.forename: Luciana I
authors.initials: LI
authors.lastname: Oklander
authors.affiliation: Estación Biológica de Corrientes, Consejo Nacional de Investigaciones Científicas y Técnicas, Museo Argentino de Ciencias Naturales Bernardino Rivadavia, San Cayetano, Corrientes, Argentina.
authors.forename: Martín M
authors.initials: MM
authors.lastname: Kowalewski
authors.affiliation: Instituto de Ciencias Veterinarias del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional del Litoral, Esperanza, Santa Fe, Argentina.
authors.forename: Pablo M
authors.initials: PM
authors.lastname: Beldomenico
authors.affiliation: Instituto Nacional de Enfermedades Virales Humanas Dr Julio I Maiztegui, Buenos Aires, Argentina.
authors.forename: Silvina
authors.initials: S
authors.lastname: Goenaga
authors.affiliation: Instituto de Biología Subtropical, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Misiones, Puerto Iguazú, Misiones, Argentina.
authors.forename: Mariela
authors.initials: M
authors.lastname: Martínez
authors.affiliation: Instituto Nacional de Medicina Tropical, Puerto Iguazú, Misiones, Argentina.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lestani
authors.affiliation: Royal Zoological Society of Scotland, Edinburgh, Scotland, UK.
authors.forename: Arnaud L J
authors.initials: AL
authors.lastname: Desbiez
authors.affiliation: International Union for Conservation of Nature, Apple Valley, MN, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Miller
mesh_terms: D000508:Alouatta / Q000821:virology*; D000818:Animals; D001118:Argentina / Q000453:epidemiology; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D008297:Male; D008992:Monkey Diseases / Q000453:epidemiology* / Q000821:virology; D011157:Population Dynamics; D015004:Yellow Fever / Q000453:epidemiology / Q000662:veterinary*