title: Streptococcus pneumoniae proteomics: determinants of pathogenesis and vaccine development.
abstract: Streptococcus pneumoniae is a major pathogen that is responsible for a variety of invasive diseases. The bacteria gain entry initially by establishing a carriage state in the nasopharynx from where they migrate to other sites in the body. The worldwide distribution of the bacteria and the severity of the diseases have led to a significant level of interest in the development of vaccines against the bacteria. Current vaccines, based on the bacterial polysaccharide, have a number of limitations including poor immunogenicity and limited effectiveness against all pneumococcal serotypes. There are many challenges in developing vaccines that will be effective against the diverse range of isolates and serotypes for this highly variable bacterial pathogen. This review considers how proteomic technologies have extended our understanding of the pathogenic mechanisms of nasopharyngeal colonization and disease development as well as the critical areas in developing protein-based vaccines.
authors.affiliation: a Division of Applied Medicine , University of Aberdeen , Aberdeen , Scotland.
authors.forename: Mustapha
authors.initials: M
authors.lastname: Bittaye
authors.affiliation: a Division of Applied Medicine , University of Aberdeen , Aberdeen , Scotland.
authors.forename: Phil
authors.initials: P
authors.lastname: Cash
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000276:immunology; D002473:Cell Wall / Q000737:chemistry / Q000276:immunology; D020543:Proteome / Q000737:chemistry / Q000276:immunology*; D022541:Streptococcal Vaccines / Q000737:chemistry / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000737:chemistry / Q000276:immunology* / Q000472:pathogenicity
chemical_list: D001426:Bacterial Proteins; D020543:Proteome; D022541:Streptococcal Vaccines
keywords: Cell wall proteins; Streptococcus pneumoniae; pathogenesis; proteome; vaccines