title: Impact of miRNAs on cardiovascular aging.
abstract: Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs (miRNAs) have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggests that changes in miRNA expression profiles contribute to cellular senescence, aging and aging-related diseases. However, only a few miRNAs whose functions have been elucidated have been associated with aging and/or aging-related diseases. This article reviews the currently available findings regarding the roles of aging-related miRNAs, with a focus on cardiac and cardiovascular aging.
authors.affiliation: Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea ; Catholic Kwandong University International St. Mary's Hospital, Incheon Metropolitan City, South Korea.
authors.forename: Seahyoung
authors.initials: S
authors.lastname: Lee
authors.affiliation: Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea ; Catholic Kwandong University International St. Mary's Hospital, Incheon Metropolitan City, South Korea.
authors.forename: Eunhyun
authors.initials: E
authors.lastname: Choi
authors.affiliation: Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea ; Catholic Kwandong University International St. Mary's Hospital, Incheon Metropolitan City, South Korea.
authors.forename: Min-Ji
authors.initials: MJ
authors.lastname: Cha
authors.affiliation: Department of Healthcare Management, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwond-do, South Korea.
authors.forename: Ae-Jun
authors.initials: AJ
authors.lastname: Park
authors.affiliation: Department of Cardiovascular & Thoracic Surgery, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwond-do, South Korea.
authors.forename: Cheesoon
authors.initials: C
authors.lastname: Yoon
authors.affiliation: Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea ; Catholic Kwandong University International St. Mary's Hospital, Incheon Metropolitan City, South Korea.
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Hwang
keywords: Aging heart; Cardiovascular aging; Senescence; Vascular aging; miRNA