title: Unusual case of drug-induced cholestasis due to glucosamine and chondroitin sulfate.
abstract: Glucosamine (GS) and chondroitin sulfate (CS) are common over-the-counter (OTC) supplements used in the treatment of osteoarthritis. These medications are seemingly safe, but there are increasing reports of hepatotoxicity with these supplements. We reported a unique case of drug-induced cholestasis caused by GS and CS in a combination tablet. The etiology of the jaundice was overlooked despite extensive investigations over a three-month period. Unlike drug-induced hepatocellular injury, drug-induced cholestatic jaundice with GS and CS has only been reported twice before. This case emphasizes the importance of a complete medication history, especially OTC supplements, in the assessment of cholestasis.
authors.affiliation: Stephen Ip, Eric M Yoshida, Division of Gastroenterology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Ip
authors.affiliation: Stephen Ip, Eric M Yoshida, Division of Gastroenterology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
authors.forename: Rachel
authors.initials: R
authors.lastname: Jeong
authors.affiliation: Stephen Ip, Eric M Yoshida, Division of Gastroenterology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
authors.forename: David F
authors.initials: DF
authors.lastname: Schaeffer
authors.affiliation: Stephen Ip, Eric M Yoshida, Division of Gastroenterology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Yoshida
keywords: Cholestasis; Chondroitin; Glucosamine; Hepatotoxicity; Jaundice