title: Heterofunctional Glycopolypeptides by Combination of Thiol-Ene Chemistry and NCA Polymerization.
abstract: Glycopolypeptides are prepared either by the polymerization of glycosylated amino acid N-carboxyanhydrides (NCAs) or by the post-polymerization functionalization of polypeptides with suitable functional groups. Here we present a method for the in-situ functionalization and (co-) polymerization of allylglycine N-carboxyanhydride in a facile one-pot procedure, combining radical thiol-ene photochemistry and nucleophilic ring-opening polymerization techniques, to yield well-defined heterofunctional glycopolypeptides.
authors.affiliation: Department of Colloid Chemistry, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, 14424, Potsdam, Germany.
authors.forename: Kai-Steffen
authors.initials: KS
authors.lastname: Krannig
authors.affiliation: Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam, Germany. schlaad@uni-potsdam.de.
authors.forename: Helmut
authors.initials: H
authors.lastname: Schlaad
mesh_terms: D000812:Anhydrides / Q000737:chemistry; D006020:Glycopeptides / Q000138:chemical synthesis*; D010777:Photochemistry; D058105:Polymerization
chemical_list: D000812:Anhydrides; D006020:Glycopeptides
keywords: Amino acid N-carboxyanhydride; Glyco; Photochemistry; Polypeptides; Thiol-ene