title: Soft tissue regeneration using leukocyte-platelet rich fibrin after exeresis of hyperplastic gingival lesions: two case reports.
abstract: BACKGROUND
  Leukocyte-platelet rich fibrin belongs to a second generation of platelet concentrates that does not need biochemical blood manipulation. It is used for tissue healing and regeneration in periodontal and oral-maxillofacial surgery. We report two cases of hyperplastic gingival lesions treated by exeresis and application of leukocyte-platelet rich fibrin membranes in order to improve and accelerate tissue healing.
  
  
  METHODS
  Two patients (a 78-year-old Caucasian woman and a 30-year-old Caucasian man) were treated for hyperplastic gingival lesions. They underwent to exeresis of lesions and application of leukocyte-platelet rich fibrin membranes. Tissue healing was clinically evaluated after 1, 3, 7, 14 and 30 postoperative days. No recurrences were observed after 2 years of semi-annual follow up.
  
  
  CONCLUSIONS
  We obtained rapid and good healing of soft tissues probably due to the elevated content of leukocytes, platelets and growth factors in the leukocyte-platelet rich fibrin. Based on our results we suggest the use of leukocyte-platelet rich fibrin to cover wounds after exeresis of oral neoformations such as hyperplastic gingival lesions.
authors.affiliation: Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Via Pansini 5, Naples, 80131, Italy. alessandroespedito.dilauro@unina.it.
authors.forename: A E
authors.initials: AE
authors.lastname: di Lauro
authors.affiliation: Private Practice, Oral Surgery Specialist, Naples, Italy. abbate-domenico82@libero.it.
authors.forename: D
authors.initials: D
authors.lastname: Abbate
authors.affiliation: Private Practice, Oral Surgery Specialist, Naples, Italy. bdellangelo@hotmail.it.
authors.forename: B
authors.initials: B
authors.lastname: Dell'Angelo
authors.affiliation: Private Practice, Oral Surgery Specialist, Naples, Italy. gianalfredo79@hotmail.com.
authors.forename: G A
authors.initials: GA
authors.lastname: Iannaccone
authors.affiliation: Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Via Pansini 5, Naples, 80131, Italy. fabioscotto89@hotmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Scotto
authors.affiliation: Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Via Pansini 5, Naples, 80131, Italy. gilberto.sammartino@unina.it.
authors.forename: G
authors.initials: G
authors.lastname: Sammartino
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006101:Granuloma, Giant Cell / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D011862:Radiography, Panoramic; D012038:Regeneration / Q000187:drug effects*
chemical_list: D005337:Fibrin