title: Towards structural classification of long non-coding RNAs.
abstract: While long non-coding RNAs play key roles in disease and development, few structural studies have been performed to date for this emerging class of RNAs. Previous structural studies are reviewed, and a pipeline is presented to determine secondary structures of long non-coding RNAs. Similar to riboswitches, experimentally determined secondary structures of long non-coding RNAs for one species, may be used to improve sequence/structure alignments for other species. As riboswitches have been classified according to their secondary structure, a similar scheme could be used to classify long non-coding RNAs. This article is part of a Special Issue titled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.
authors.affiliation: Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Electronic address: kys@lanl.gov.
authors.forename: Karissa Y
authors.initials: KY
authors.lastname: Sanbonmatsu
mesh_terms: D001483:Base Sequence; D006801:Humans; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D016415:Sequence Alignment
chemical_list: D062085:RNA, Long Noncoding; C405423:steroid receptor RNA activator; D012313:RNA
keywords: Long non-coding RNA; Non-coding RNA; RNA; RNA biochemistry; RNA structure