title: Quality and Safety of General Anesthesia with Propofol and Sevoflurane in Children Aged 1-14 Based on Laboratory Parameters.
abstract: BACKGROUND
  Knowledge of anatomic, physiological, biochemical and physical characteristics of children of all age groups, the existing illness and possible pathological response of the organism to the existing situation, require a pediatric anesthesiologist to participate in the preparation of a child for surgical treatment, to choose the best anesthesia technique and medications, and manipulative techniques to enable the scheduled surgical treatment with minimum anesthesia risks. The aim of this clinical study was to prove reliability and quality of propofol or sevoflurane general anesthesia in children in the age group of 1-14 years from the ASA I group and in the elective surgical treatments in duration of 60 minutes, based on preoperative and postoperative levels of laboratory findings (transaminases, blood sugar, urea and creatinine).
  
  
  METHODS
  the study included 160 patients randomized in two groups based on different approaches: total intravenous anesthesia was used for the propofol group (n=80) (TIVA) and the inhalation technique was used for the sevoflurane group (n=80).
  
  
  RESULTS
  statistical evaluation of the obtained results indicates stability of laboratory findings in the immediate postoperative course (after 24 hours) in respect to the preoperative period. Based on the Mann Whitney test (P), preoperative and postoperative blood sugar levels in the sevoflurane vs. propofol group were P=0.152 vs. 0.021; creatinine levels P=0.113 vs. 0.325; urea levels P= 0.016 vs. 0.900; AST levels P=0,031 vs. 0,268 and ALT levels P=0.021 vs. 0.058. Level of significance was P<0.5.
  
  
  CONCLUSIONS
  Analysis of the examined laboratory parameters show that propofol and sevoflurane provide full security and quality of general anesthesia in children age group 1-14 years, from the ASA I group. All analyzed laboratory levels in the postoperative course remained in their referential values in both groups of participants.
authors.affiliation: Clinic of Anesthesiology and Reanimation, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Selma
authors.initials: S
authors.lastname: Vanis-Vatrenjak
authors.affiliation: Clinic of Anesthesiology and Reanimation, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Amira
authors.initials: A
authors.lastname: Mesic
authors.affiliation: Clinic of Anesthesiology and Reanimation, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Ines
authors.initials: I
authors.lastname: Abdagic
authors.affiliation: Clinic of Anesthesiology and Reanimation, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Djenita
authors.initials: D
authors.lastname: Mujezinovic
authors.affiliation: Clinic of Pediatric Surgery, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Zlatan
authors.initials: Z
authors.lastname: Zvizdic
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General / Q000009:adverse effects / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000009:adverse effects; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects; D015742:Propofol / Q000009:adverse effects; D000077149:Sevoflurane; D014508:Urea / Q000097:blood
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D001786:Blood Glucose; D008738:Methyl Ethers; D000077149:Sevoflurane; D014508:Urea; D015742:Propofol
keywords: laboratory values; pediatric anesthesia; propofol; sevoflurane