title: Renal Interstitial Arteriosclerotic Lesions in Lupus Nephritis Patients: A Cohort Study from China.
abstract: OBJECTIVE
  The aim of this study was to evaluate renal arteriosclerotic lesions in patients with lupus nephritis and investigate their associations with clinical and pathological characteristics, especially cardio-vascular features.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  Seventy-nine patients with renal biopsy-proven lupus nephritis, diagnosed between January 2000 and June 2008 from Peking University First Hospital.
  
  
  RESULTS
  In clinico-pathological data, patients with arteriosclerosis had higher ratio of hypertension and more severe renal injury indices compared with patients with no renal vascular lesions. More importantly, patients with renal arteriosclerosis had worse cardiac structure and function under transthoracic echocardiographic examination. Patients with renal arteriosclerosis tend to have higher ratios of combined endpoints compared with those of no renal vascular lesions, although the difference didn't reach statistical meanings (P = 0.104).
  
  
  CONCLUSIONS
  Renal arteriosclerotic lesion was common and associated with vascular immune complex deposits in lupus nephritis. It might have a certain degree of association with poor outcomes and cardiovascular events, which needs further explorations.
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034 PR China.|Institute of Nephrology, Peking University, Beijing, 100034, PR China.|Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, 100034, PR China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034 PR China.|Institute of Nephrology, Peking University, Beijing, 100034, PR China.|Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, 100034, PR China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, PR China.
authors.forename: Sha-sha
authors.initials: SS
authors.lastname: Han
authors.affiliation: Department of Nephrology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150000, PR China.
authors.forename: Dan-dan
authors.initials: DD
authors.lastname: Qin
authors.affiliation: Department of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China.
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Wu
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of Chinese PLA General Hospital, 51 Fucheng Road, Beijing, 100048, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034 PR China.|Institute of Nephrology, Peking University, Beijing, 100034, PR China.|Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, 100034, PR China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034 PR China.|Institute of Nephrology, Peking University, Beijing, 100034, PR China.|Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, 100034, PR China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, PR China.
authors.forename: Su-xia
authors.initials: SX
authors.lastname: Wang
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034 PR China.|Institute of Nephrology, Peking University, Beijing, 100034, PR China.|Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, 100034, PR China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034 PR China.|Institute of Nephrology, Peking University, Beijing, 100034, PR China.|Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, 100034, PR China.|Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, PR China.|Peking-Tsinghua Center for Life Sciences, Beijing, PR China.
authors.forename: Ming-hui
authors.initials: MH
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000150:complications*; D000068476:Beijing; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D008181:Lupus Nephritis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012306:Risk; D055815:Young Adult