title: SATPdb: a database of structurally annotated therapeutic peptides.
abstract: SATPdb (http://crdd.osdd.net/raghava/satpdb/) is a database of structurally annotated therapeutic peptides, curated from 22 public domain peptide databases/datasets including 9 of our own. The current version holds 19192 unique experimentally validated therapeutic peptide sequences having length between 2 and 50 amino acids. It covers peptides having natural, non-natural and modified residues. These peptides were systematically grouped into 10 categories based on their major function or therapeutic property like 1099 anticancer, 10585 antimicrobial, 1642 drug delivery and 1698 antihypertensive peptides. We assigned or annotated structure of these therapeutic peptides using structural databases (Protein Data Bank) and state-of-the-art structure prediction methods like I-TASSER, HHsearch and PEPstrMOD. In addition, SATPdb facilitates users in performing various tasks that include: (i) structure and sequence similarity search, (ii) peptide browsing based on their function and properties, (iii) identification of moonlighting peptides and (iv) searching of peptides having desired structure and therapeutic activities. We hope this database will be useful for researchers working in the field of peptide-based therapeutics.
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singh
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors.forename: Kumardeep
authors.initials: K
authors.lastname: Chaudhary
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors.forename: Sandeep Kumar
authors.initials: SK
authors.lastname: Dhanda
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors.forename: Sherry
authors.initials: S
authors.lastname: Bhalla
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors.forename: Salman Sadullah
authors.initials: SS
authors.lastname: Usmani
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Gautam
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Tuknait
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors.forename: Piyush
authors.initials: P
authors.lastname: Agrawal
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Mathur
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India raghava@imtech.res.in.
authors.forename: Gajendra P S
authors.initials: GP
authors.lastname: Raghava
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D062313:Databases, Pharmaceutical; D058977:Molecular Sequence Annotation; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D010455:Peptides