title: Targeted polymer-drug conjugates: Current progress and future perspective.
abstract: The combination of polymer technology and targeted drug delivery may pave the way for more effective yet safer therapeutic options for cancer therapy. Polymer-drug conjugates belonging to polymer therapeutics represent an emerging approach for drug delivery. The development of smart targeted polymer-drug conjugates that can specifically deliver drugs at a sustained rate to tumor cells may substantially improve the therapeutic index of anticancer agents. In this update, we provide an overview of the most important targeting molecules, and systemically summarize the recent advances in the development of tumor-targeted polymer-drug conjugates. Additionally, several promising approaches for the future will also be presented.
authors.affiliation: Department of pharmacy, People's Hospital of Linzi District, Linzi, Shandong Province 255400, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of pharmacy, People's Hospital of Linzi District, Linzi, Shandong Province 255400, China. Electronic address: hfma0533@126.com.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of pharmacy, People's Hospital of Linzi District, Linzi, Shandong Province 255400, China.
authors.forename: Peimin
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of pharmacy, People's Hospital of Linzi District, Linzi, Shandong Province 255400, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of pharmacy, People's Hospital of Linzi District, Linzi, Shandong Province 255400, China.
authors.forename: Xiangxia
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of pharmacy, People's Hospital of Linzi District, Linzi, Shandong Province 255400, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Yin
authors.affiliation: Department of pharmacy, People's Hospital of Linzi District, Linzi, Shandong Province 255400, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of pharmacy, People's Hospital of Linzi District, Linzi, Shandong Province 255400, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Xu
mesh_terms: D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: Active targeting; Cancer therapy; Drug delivery; Passive targeting; Polymer-drug conjugates