title: Food Restriction Ameliorates the Development of Polycystic Kidney Disease.
abstract: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the accumulation of kidney cysts that ultimately leads to loss of renal function and kidney failure. At present, the treatment for ADPKD is largely supportive. Multiple studies have focused on pharmacologic approaches to slow the development of the cystic disease; however, little is known about the role of nutrition and dietary manipulation in PKD. Here, we show that food restriction (FR) effectively slows the course of the disease in mouse models of ADPKD. Mild to moderate (10%-40%) FR reduced cyst area, renal fibrosis, inflammation, and injury in a dose-dependent manner. Molecular and biochemical studies in these mice indicate that FR ameliorates ADPKD through a mechanism involving suppression of the mammalian target of the rapamycin pathway and activation of the liver kinase B1/AMP-activated protein kinase pathway. Our data suggest that dietary interventions such as FR, or treatment that mimics the effects of such interventions, may be potential and novel preventive and therapeutic options for patients with ADPKD.
authors.affiliation: Department of Anesthesiology, Robert and Arlene Kogod Center on Aging, and.
authors.forename: Gina
authors.initials: G
authors.lastname: Warner
authors.affiliation: Department of Anesthesiology, Robert and Arlene Kogod Center on Aging, and.
authors.forename: Kyaw Zaw
authors.initials: KZ
authors.lastname: Hein
authors.affiliation: Department of Anesthesiology, Robert and Arlene Kogod Center on Aging, and.
authors.forename: Veronica
authors.initials: V
authors.lastname: Nin
authors.affiliation: Department of Anesthesiology, Robert and Arlene Kogod Center on Aging, and.
authors.forename: Marika
authors.initials: M
authors.lastname: Edwards
authors.affiliation: Department of Anesthesiology, Robert and Arlene Kogod Center on Aging, and chini.eduardo@mayo.edu.
authors.forename: Claudia C S
authors.initials: CC
authors.lastname: Chini
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
authors.forename: Katharina
authors.initials: K
authors.lastname: Hopp
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Harris
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
authors.forename: Vicente E
authors.initials: VE
authors.lastname: Torres
authors.affiliation: Department of Anesthesiology, Robert and Arlene Kogod Center on Aging, and chini.eduardo@mayo.edu.
authors.forename: Eduardo N
authors.initials: EN
authors.lastname: Chini
mesh_terms: D000818:Animals; D015415:Biomarkers; D004195:Disease Models, Animal; D005260:Female; D005502:Food; D008297:Male; D051379:Mice; D016891:Polycystic Kidney, Autosomal Dominant / Q000178:diet therapy* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015415:Biomarkers
keywords: ADPKD; AMPK; mTOR; metabolism; nutrition; polycystic kidney disease