title: Involvement of periostin-sclerostin-Wnt/β-catenin signaling pathway in the prevention of neurectomy-induced bone loss by naringin.
abstract: Periostin has an essential role in mechanotransduction in bone. Naringin, a natural flavonoid, has been evidenced for its osteoprotective role in osteoporosis, while its mechanism is far from clear. Here we show that down-regulation of periostin, and up-regulation of its downstream sclerostin and inactivation of Wnt/β-catenin signaling were implicated in neurectomy-induced bone loss. Naringin could up-regulate periostin and prevent neurectomy-induced deterioration of BMD, trabecular microstructure and bone mechanical characteristics. In conclusion, naringin could prevent progress of disuse osteoporosis in rats, which may be mediated by increased periostin expression and subsequently inhibition of sclerostin and activation of Wnt/β-catenin signaling pathways.
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China; Graduate School of Tianjin Medical University, No. 22, Qixiangtai Street, Heping District, Tianjin TJ 300070, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Lv
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Sun
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Ma
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China; Graduate School of Tianjin Medical University, No. 22, Qixiangtai Street, Heping District, Tianjin TJ 300070, China. Electronic address: gengxiao502@163.com.
authors.forename: Xinlong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Xing
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China.
authors.forename: Jianbao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China.
authors.forename: Fengbo
authors.initials: F
authors.lastname: Li
authors.affiliation: Institute of Orthopedics, Tianjin Hospital, No. 122, Munan Road, Heping District, Tianjin TJ 300050, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D044950:Flavanones / Q000008:administration & dosage*; D005819:Genetic Markers; D008297:Male; D019635:Neurosurgical Procedures / Q000009:adverse effects; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000601:surgery; D016896:Treatment Outcome; D060449:Wnt Signaling Pathway / Q000187:drug effects*
chemical_list: D019485:Bone Morphogenetic Proteins; D015815:Cell Adhesion Molecules; D044950:Flavanones; D005819:Genetic Markers; C512836:Postn protein, rat; C486031:Sost protein, rat; C005274:naringin
keywords: Disuse osteoporosis; Naringin; Periostin; Sclerostin; β-catenin