title: Communication of bone cells with hematopoiesis, immunity and energy metabolism.
abstract: The bone contains the bone marrow. The functional communication between bone cells and hematopoiesis has been extensively studied in the past decade or so. Osteolineage cells and their modulators, such as the sympathetic nervous system, macrophages and osteoclasts, form a complex unit to maintain the homeostasis of hematopoiesis, called the 'microenvironment'. Recently, bone-embedded osteocytes, the sensors of gravity and mechanical stress, have joined the microenvironment, and they are demonstrated to contribute to whole body homeostasis through the control of immunity and energy metabolism. The inter-organ communication orchestrated by the bone is summarized in this article.
authors.affiliation: Division of Hematology, Department of Medicine, Kobe University Graduate School of Medicine , Kobe, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Asada
authors.affiliation: Division of Hematology, Department of Medicine, Kobe University Graduate School of Medicine , Kobe, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Sato
authors.affiliation: Division of Hematology, Department of Medicine, Kobe University Graduate School of Medicine , Kobe, Japan ; Department of Hematology, Kobe University Hospital , Kobe, Japan ; PRESTO, Japan Science and Technology Agency , Kawaguchi, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Katayama