title: Chemotherapy Induced Acute Pericarditis in a Child.
abstract: A9 years boy diagnosed with nasopharyngeal carcinoma was started on chemotherapy protocol including 5-fluorouracil. After 90 hours of 5-fluorouracil infusion, he developed severe retrosternal chest pain. Electrocardiography showed signs of acute pericarditis and was managed with ibuprofen and 5-fluorouracil was discontinued. The 5-fluorouracil rarely causes cardiac complications such as angina pectoris and pericarditis in adult patients. We report acute myopericarditis in a child caused by 5-fluorouracil, which is a very rare complication of 5-fluorouracil in pediatric age group.
authors.affiliation: Department of Pediatric Cardiology, King Salman Heart Centre, King Fahad Medical City, Riyadh, KSA.
authors.forename: Muhammad Arif
authors.initials: MA
authors.lastname: Khan
authors.affiliation: Department of Pediatric Cardiology, King Salman Heart Centre, King Fahad Medical City, Riyadh, KSA.
authors.forename: Abdul
authors.initials: A
authors.lastname: Rahman
authors.affiliation: Department of Pediatric Cardiology, King Salman Heart Centre, King Fahad Medical City, Riyadh, KSA.
authors.forename: S
authors.initials: S
authors.lastname: Almoukirish
authors.affiliation: Department of Pediatric Cardiology, King Salman Heart Centre, King Fahad Medical City, Riyadh, KSA.
authors.forename: Shehla
authors.initials: S
authors.lastname: Jadoon
authors.affiliation: Department of Pediatric Cardiology, King Salman Heart Centre, King Fahad Medical City, Riyadh, KSA.
authors.forename: Tarek S
authors.initials: TS
authors.lastname: Momenah
mesh_terms: D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001706:Biopsy; D002277:Carcinoma; D002637:Chest Pain / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D002648:Child; D004562:Electrocardiography; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D007260:Infusion Pumps; D008279:Magnetic Resonance Imaging; D008297:Male; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D010493:Pericarditis / Q000139:chemically induced* / Q000188:drug therapy; D013616:Tachycardia, Sinus; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005472:Fluorouracil; D007052:Ibuprofen