title: Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates.
abstract: To date, most antibodies from combinatorial libraries have been selected purely on the basis of binding. However, new methods now allow selection on the basis of function in animal cells. These selected agonist antibodies have given new insights into the important problem of signal transduction. Remarkably, when some antibodies bind to a given receptor they induce a cell fate that is different than that induced by the natural agonist to the same receptor. The fact that receptors can be functionally pleiotropic may yield new insights into the important problem of signal transduction.
authors.affiliation: Department of Cell and Molecular Biology,The Scripps Research Institute,La Jolla,CA 92037,USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lerner
authors.affiliation: Department of Cell and Molecular Biology,The Scripps Research Institute,La Jolla,CA 92037,USA.
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Grover
authors.affiliation: Department of Cell and Molecular Biology,The Scripps Research Institute,La Jolla,CA 92037,USA.
authors.forename: Hongkai
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Cell and Molecular Biology,The Scripps Research Institute,La Jolla,CA 92037,USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Cell and Molecular Biology,The Scripps Research Institute,La Jolla,CA 92037,USA.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Han
authors.affiliation: Department of Cell and Molecular Biology,The Scripps Research Institute,La Jolla,CA 92037,USA.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Shanghai Institute for Advance Immunological Studies,ShanghaiTech University,Shanghai 200031,China.
authors.forename: Kyungmoo
authors.initials: K
authors.lastname: Yea
mesh_terms: D000068879:Adalimumab / Q000737:chemistry; D000818:Animals; D000906:Antibodies / Q000737:chemistry*; D018952:Antigens, CD34 / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology; D017104:Bacteriophage M13; D002454:Cell Differentiation; D019070:Cell Lineage; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003593:Cytoplasm / Q000378:metabolism; D004277:DNA, Single-Stranded / Q000737:chemistry; D006801:Humans; D007107:Immune System; D016086:Lentivirus / Q000235:genetics; D010641:Phenotype; D012270:Ribosomes / Q000737:chemistry; D015398:Signal Transduction
chemical_list: D000906:Antibodies; D018952:Antigens, CD34; D004277:DNA, Single-Stranded; D000068879:Adalimumab
keywords: Cell Fates Regulations; Combinatorial Libraries; Pleiotropism