title: Primary Cardiac Angiosarcoma Treated With Positron Emission Tomography/Magnetic Resonance Imaging-Guided Adaptive Radiotherapy.
abstract: Radiotherapy (RT) for inoperable patients with primary cardiac sarcomas or residual tumor is often limited by the sensitivity of the heart and lung to radiation injury. We describe a novel treatment modality with adaptive radiotherapy (ART) using tumor volume tracking in a 37-year-old woman who presented with unresectable primary cardiac angiosarcoma. The patient was treated using positron emission tomography/magnetic resonance imaging-guided ART with 55.8 Gy concomitant with paclitaxel chemotherapy. In conclusion, the treatment was well tolerated, and a significant tumor volume reduction of ∼ 57% was achieved during radiotherapy, suggesting the effectiveness and tolerability of ART in combination with paclitaxel-based chemotherapy.
authors.affiliation: Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany. Electronic address: khaled.elsayad@uni-muenster.de.
authors.forename: Khaled
authors.initials: K
authors.lastname: Elsayad
authors.affiliation: Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Lehrich
authors.affiliation: Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
authors.forename: Heidi
authors.initials: H
authors.lastname: Yppaerilae-Wolters
authors.affiliation: Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
authors.forename: Chantal
authors.initials: C
authors.lastname: Dieckmann
authors.affiliation: Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Kriz
authors.affiliation: Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Haverkamp
authors.affiliation: Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
authors.forename: Hans Theodor
authors.initials: HT
authors.lastname: Eich
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D059248:Chemoradiotherapy / Q000379:methods; D005260:Female; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D017239:Paclitaxel / Q000627:therapeutic use; D049268:Positron-Emission Tomography / Q000379:methods; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D017239:Paclitaxel