title: Prognostic value of clinicopathological characteristics in patients with pancreatic cancer.
abstract: BACKGROUND
  The purpose of this study was to analyze the effects of all clinical characteristics on the overall survival time, in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer.
  
  
  METHODS
  A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital, Shanghai Jiaotong University School of Medicine, between January 2002 and December 2012. There were 68 men and 35 women; the median age was 62 years. Diagnoses of pancreatic cancer in all patients were confirmed by histopathology, cytology, or clinical diagnosis. The Kaplan-Meier method was performed to calculate the overall survival rate. The log-rank method was used to examine the univariate analysis. The Cox regression model was performed for multivariate analysis.
  
  
  RESULTS
  The median survival time was 293 days, the 1-, 2-, and 3-year survival rates were 27.18%, 5.83%, and 1.94%, respectively. Cox regression analysis revealed that age (P=0.015), Karnofsky performance status (PS) (P=0.002), surgical types (P<0.001), and platelet counts (P<0.001) were independent prognostic factors affecting the overall survival of patients with pancreatic cancer.
  
  
  CONCLUSIONS
  Pancreatic cancer had a poor prognosis, the general physical condition, age, the availability of radical surgery, and platelet counts were factors influencing the overall survival of patients with pancreatic cancer.
authors.affiliation: 1 Department of Oncology, 2 Department of Radiation Oncology, Ruijin Hosptial, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Geng
authors.affiliation: 1 Department of Oncology, 2 Department of Radiation Oncology, Ruijin Hosptial, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Haoping
authors.initials: H
authors.lastname: Xu
authors.affiliation: 1 Department of Oncology, 2 Department of Radiation Oncology, Ruijin Hosptial, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Ruobing
authors.initials: R
authors.lastname: Ren
authors.affiliation: 1 Department of Oncology, 2 Department of Radiation Oncology, Ruijin Hosptial, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Qu
authors.affiliation: 1 Department of Oncology, 2 Department of Radiation Oncology, Ruijin Hosptial, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Chengfang
authors.initials: C
authors.lastname: Shangguan
authors.affiliation: 1 Department of Oncology, 2 Department of Radiation Oncology, Ruijin Hosptial, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Wu
authors.affiliation: 1 Department of Oncology, 2 Department of Radiation Oncology, Ruijin Hosptial, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Jiang
authors.affiliation: 1 Department of Oncology, 2 Department of Radiation Oncology, Ruijin Hosptial, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: 1 Department of Oncology, 2 Department of Radiation Oncology, Ruijin Hosptial, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Cao
keywords: Pancreatic neoplasm; prognosis; survival; treatment