title: High-grade urothelial carcinoma with squamous differentiation metastasizing to the tongue.
abstract: Tumors metastasizing to the head and neck region are uncommon. Metastasis of urothelial carcinoma to the maxillofacial region is exceedingly rare and mostly involves the jaw. We present a case of urothelial carcinoma metastasizing to the tongue. Immunohistochemistry in conjunction with fluorescent in situ hybridization was used to confirm the relation between the primary and metastatic lesions, making it the first such reported case employing the UroVysion (Catalogue number 02 J27-025, Abbott Molecular Inc., Des Plaines, IL, USA) fluorescent in situ hybridization probe in a metastatic lesion in the head and neck region.
authors.affiliation: Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, 19 Claremont Crescent, Sheffield, UK. Electronic address: s.a.khurram@sheffield.ac.uk.
authors.forename: Syed A
authors.initials: SA
authors.lastname: Khurram
authors.affiliation: Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, 19 Claremont Crescent, Sheffield, UK.
authors.forename: Paula M
authors.initials: PM
authors.lastname: Farthing
authors.affiliation: Sheffield Diagnostic Genetics Service, Sheffield Children's Hospital NHS Foundation Trust, Western Bank, Sheffield, UK.
authors.forename: Abigail
authors.initials: A
authors.lastname: Whitworth
authors.affiliation: Department of Oral and Maxillofacial Surgery, Charles Clifford Dental Hospital, Wellesley Road, Sheffield, UK.
authors.forename: Alasdair J
authors.initials: AJ
authors.lastname: McKechnie
authors.affiliation: Department of Histopathology, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK.
authors.forename: Malee
authors.initials: M
authors.lastname: Fernando
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000556:secondary*; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D014062:Tongue Neoplasms / Q000556:secondary*; D001749:Urinary Bladder Neoplasms / Q000473:pathology*