title: Periostin is critical for improving the therapeutic properties of adipocyte-derived stem cells.
abstract: Periostin is a matricellular protein that is reactivated during tissue damage and repair and has been shown to be a critical regulator of multiple biological pathways involved in the repair of tissue after myocardial infarction, peripheral vascular disease, and skin wounds. The tissue repair properties attributed to periostin make it an ideal candidate to enhance the therapeutic properties of donor cells such as mesenchymal stem cells from adipocyte tissue. In a recent article in Stem Cell Research & Therapy, Qin et al. demonstrated enhanced therapeutic properties of adipocyte-derived stem cells by genetically engineering them to express periostin.
authors.affiliation: Women's and Infants' Health, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, 60 Murray Street, Box 40, Toronto, M5T 3L9, ON, Canada.|Department of Physiology, Medical Sciences Building, University of Toronto, 3rd Floor, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada.
authors.forename: Theresa
authors.initials: T
authors.lastname: Chow
authors.affiliation: Women's and Infants' Health, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, 60 Murray Street, Box 40, Toronto, M5T 3L9, ON, Canada. rogers@lunenfeld.ca.|Department of Physiology, Medical Sciences Building, University of Toronto, 3rd Floor, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada. rogers@lunenfeld.ca.|Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, 123 Edward Street, Suite 1200, Toronto, M5G 1E2, ON, Canada. rogers@lunenfeld.ca.
authors.forename: Ian M
authors.initials: IM
authors.lastname: Rogers
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency*; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D015687:Cell Hypoxia / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D007511:Ischemia / Q000378:metabolism* / Q000628:therapy*; D023821:Limb Salvage
chemical_list: D001057:Apolipoproteins E; D015815:Cell Adhesion Molecules