title: Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by deposition of amyloid plaques and neurofibrillary tangles, as well as microglial and astroglial activation, and, finally, leading to neuronal dysfunction and death. Current treatments for AD primarily focus on enhancement of cholinergic transmission. However, these treatments are only symptomatic, and no disease-modifying drug is available for the treatment of AD patients. This review will provide an overview of the antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of a variety of nutraceuticals including curcumin, apigenin, docosahexaenoic acid, epigallocatechin gallate, α-lipoic acid and resveratrol and their potential for AD prevention and treatment. We suggest that therapeutic use of these compounds might lead to a safe strategy to delay the onset of AD or slow down its progression. The continuing investigation of the potential of these substances is necessary as they are promising compounds to yield a possible remedy for this pervasive disease.
authors.affiliation: Dept of Pharmacology, School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Venigalla
authors.affiliation: Dept of Pharmacology, School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Sonego
authors.affiliation: Dept of Pharmacology, School of Medicine, Western Sydney University, Campbelltown, NSW, Australia; Molecular Medicine Research Group, Western Sydney University, Campbelltown, NSW, Australia.
authors.forename: Erika
authors.initials: E
authors.lastname: Gyengesi
authors.affiliation: School of Health Sciences, University of Tasmania, Australia.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Sharman
authors.affiliation: Dept of Pharmacology, School of Medicine, Western Sydney University, Campbelltown, NSW, Australia; National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW, Australia; Molecular Medicine Research Group, Western Sydney University, Campbelltown, NSW, Australia. Electronic address: g.muench@uws.edu.au.
authors.forename: Gerald
authors.initials: G
authors.lastname: Münch
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000627:therapeutic use*; D001688:Biological Products / Q000302:isolation & purification / Q000627:therapeutic use*; D002908:Chronic Disease; D003474:Curcumin / Q000302:isolation & purification / Q000627:therapeutic use; D005395:Fish Oils / Q000302:isolation & purification / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D016874:Neurofibrillary Tangles / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D000077185:Resveratrol; D013267:Stilbenes / Q000302:isolation & purification / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D001688:Biological Products; D005395:Fish Oils; D018696:Neuroprotective Agents; D013267:Stilbenes; D003474:Curcumin; D000077185:Resveratrol
keywords: Alzheimer's disease; Apigenin; Curcumin; Fish oil; Green tea; Lipoic acid; Neuroinflammation