title: Feeding response following central administration of mesotocin and arginine-vasotocin receptor agonists in chicks (Gallus gallus).
abstract: Mesotocin (MT) and arginine-vasotocin (AVT) are posterior pituitary derived hormones in birds and are homologous to mammalian oxytocin (OT) and vasopressin (VP), respectively. We previously reported that intracerebroventricular (ICV) injection of both MT and AVT inhibit feeding and induce wing-flapping in chicks (Gallus gallus). Because both peptides cause similar effects suggests that they might act via common receptors. However, the specific receptors of MT and AVT which mediate their anorexigenic effect have not been clarified in chicks. Thus, the purpose of the present study was to identify the receptor subtypes involved in MT- and AVT-induced anorexia and behavioral patterns by using several agonists. ICV injection of vasopressin-1 receptor agonist (V1R) (homologous to chicken AVT receptor-2 and -4 [VT2R and VT4R, respectively]), significantly decreased food intake while agonists of vasopressin-2 receptor (V2R) and OT receptor (OTR) (homologues of chicken AVT receptor-1 and MT receptor respectively) had no effect. In addition, V1R agonist induced wing-flapping although this was not affected by V2R or OTR agonists. Since VT2R has not been found in the brain of chicks, the present study suggested that VT4R might be related to the anorexigenic effect and wing-flapping induced by MT and AVT in chicks.
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Masunari
authors.affiliation: Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Cline
authors.affiliation: Laboratory of Animal Production, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
authors.forename: Sakirul Islam
authors.initials: SI
authors.lastname: Khan
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States. Electronic address: tetsu@agr.ehime-u.ac.jp.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tachibana
mesh_terms: D000818:Animals; D002645:Chickens; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage / Q000819:agonists / Q000031:analogs & derivatives* / Q000494:pharmacology; D011979:Receptors, Pituitary Hormone / Q000819:agonists*; D017483:Receptors, Vasopressin / Q000819:agonists*; D014921:Wings, Animal / Q000187:drug effects / Q000502:physiology
chemical_list: D011979:Receptors, Pituitary Hormone; D017483:Receptors, Vasopressin; C116046:mesotocin receptor; C034862:vasotocin receptor; C047063:oxytocin, Phe(2)-Orn(8)-; C001713:mesotocin; D010121:Oxytocin; C045427:oxytocin, Thr(4)-Gly(7)-; D003894:Deamino Arginine Vasopressin
keywords: Agonist; Arginine-vasotocin; Behavior; Feeding; Intracerebroventricular injection; Mesotocin