title: Dentin Matrix Proteins in Bone Tissue Engineering.
abstract: Dentin and bone are mineralized tissue matrices comprised of collagen fibrils and reinforced with oriented crystalline hydroxyapatite. Although both tissues perform different functionalities, they are assembled and orchestrated by mesenchymal cells that synthesize both collagenous and noncollagenous proteins albeit in different proportions. The dentin matrix proteins (DMPs) have been studied in great detail in recent years due to its inherent calcium binding properties in the extracellular matrix resulting in tissue calcification. Recent studies have shown that these proteins can serve both as intracellular signaling proteins leading to induction of stem cell differentiation and also function as nucleating proteins in the extracellular matrix. These properties make the DMPs attractive candidates for bone and dentin tissue regeneration. This chapter will provide an overview of the DMPs, their functionality and their proven and possible applications with respect to bone tissue engineering.
authors.affiliation: Brodie Tooth Development Genetics & Regenerative Medicine Research Laboratory Department of Oral Biology, University of Illinois at Chicago, Chicago, IL, 60612, USA.
authors.forename: Sriram
authors.initials: S
authors.lastname: Ravindran
authors.affiliation: Brodie Tooth Development Genetics & Regenerative Medicine Research Laboratory Department of Oral Biology, University of Illinois at Chicago, Chicago, IL, 60612, USA. anneg@uic.edu.
authors.forename: Anne
authors.initials: A
authors.lastname: George
mesh_terms: D001842:Bone and Bones / Q000378:metabolism* / Q000502:physiology; D002113:Calcification, Physiologic / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D003804:Dentin / Q000378:metabolism* / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D012038:Regeneration / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D016326:Extracellular Matrix Proteins; D010750:Phosphoproteins; D020033:Protein Isoforms; D002118:Calcium
keywords: Bone regeneration; DMP1; DMP4; DPP; DSP; Dentin matrix proteins; FAM20C; Tissue engineering