title: Atrial fibrillation in patients with diabetes: molecular mechanisms and therapeutic perspectives.
abstract: Atrial fibrillation (AF) remains the most frequent sustained cardiac arrhythmia worldwide and its incidence increases with ageing, cardiovascular risk factors and comorbidities. Prevalence of diabetes mellitus (DM) is growing fast and is assuming pandemic proportions mostly due to overnutrition and sedentary habits. Experimental and clinical evidences suggest that DM and AF are strongly interconnected. The present review addresses in detail new molecular pathways implicated in the etiology of AF and their relevance for mechanism-based therapeutic strategies in this setting. Advances in risk stratification, drug therapy (i.e., novel anticoagulants) and catheter ablation are also described.
authors.affiliation: 1 Arrhythmia Unit, Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 2 Arrhythmia Unit, Department of Cardiology, OLV Hospital, Aalst, Belgium ; 3 Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 4 Department of Cardiovascular Medicine, University Hospital, Münster, Germany.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Sensi
authors.affiliation: 1 Arrhythmia Unit, Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 2 Arrhythmia Unit, Department of Cardiology, OLV Hospital, Aalst, Belgium ; 3 Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 4 Department of Cardiovascular Medicine, University Hospital, Münster, Germany.
authors.forename: Tom
authors.initials: T
authors.lastname: De Potter
authors.affiliation: 1 Arrhythmia Unit, Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 2 Arrhythmia Unit, Department of Cardiology, OLV Hospital, Aalst, Belgium ; 3 Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 4 Department of Cardiovascular Medicine, University Hospital, Münster, Germany.
authors.forename: Alberto
authors.initials: A
authors.lastname: Cresti
authors.affiliation: 1 Arrhythmia Unit, Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 2 Arrhythmia Unit, Department of Cardiology, OLV Hospital, Aalst, Belgium ; 3 Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 4 Department of Cardiovascular Medicine, University Hospital, Münster, Germany.
authors.forename: Silva
authors.initials: S
authors.lastname: Severi
authors.affiliation: 1 Arrhythmia Unit, Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 2 Arrhythmia Unit, Department of Cardiology, OLV Hospital, Aalst, Belgium ; 3 Department of Cardiology, Misericordia Hospital, Grosseto, Italy ; 4 Department of Cardiovascular Medicine, University Hospital, Münster, Germany.
authors.forename: Günter
authors.initials: G
authors.lastname: Breithardt
keywords: Atrial fibrillation (AF); anticoagulants; catheter ablation; diabetes mellitus (DM)