title: Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C>A mutation.
authors.affiliation: Unité d'Hémostase Clinique - Laboratoire d'Hémostase, CHU de Lyon, University Lyon I, Lyon, France. ydargaud@univ-lyon1.fr.
authors.forename: Yesim
authors.initials: Y
authors.lastname: Dargaud
authors.affiliation: Unité d'Hémostase Clinique - Laboratoire d'Hémostase, CHU de Lyon, University Lyon I, Lyon, France.
authors.forename: Yohann
authors.initials: Y
authors.lastname: Jourdy
authors.affiliation: Unité d'Hémostase Clinique - Laboratoire d'Hémostase, CHU de Lyon, University Lyon I, Lyon, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Le Quellec
authors.affiliation: Cardiovascular Research Institute Maastricht, Synapse BV, Maastricht, The Netherlands.
authors.forename: Coenraad H
authors.initials: CH
authors.lastname: Hemker
authors.affiliation: Cardiovascular Research Institute Maastricht, Synapse BV, Maastricht, The Netherlands.
authors.forename: Theo
authors.initials: T
authors.lastname: Lindhout
authors.affiliation: Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Castoldi
authors.affiliation: Unité d'Hémostase Clinique - Laboratoire d'Hémostase, CHU de Lyon, University Lyon I, Lyon, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Negrier
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D009154:Mutation; D018180:Thrombomodulin / Q000235:genetics*
chemical_list: D006490:Hemostatics; D018180:Thrombomodulin
keywords: activated prothrombin complex concentrate; bleeding; factor VIII; platelets; thrombomodulin