title: Formulation and in-vitro evaluation of directly compressed controlled release matrices of Losartan Potassium using Ethocel Grade 100 as rate retarding agent.
abstract: Current study was aimed to develop 200mg controlled release matrix tablets of Losartan Potassium using Ethocel 100 Premium and Ethocel 100 FP Premium as rate controlling polymer. In-vitro studies were performed according to USP Method-I in phosphate buffer (PH 6.8) using pharma test dissolution apparatus. The temperature of the dissolution medium was kept constant at 37±0.5°C at 100rpm. Flow properties, physical quality control tests, effect of polymer size and drug-to-polymers ratios were studied using different kinetics models such as 1st-order, zero-order, Hixon Crowell model, Highuchi model and Power law. Difference factor f1 and similarity factor f2 were applied for dissolution profiles against Cardaktin® tablets used as a reference formulation. The matrices with polymer ethocel 100 FP Premiums have prolonged the drug release rate as compared to polymer ethocel 100 Premiums. The n values matrices with polymer ethocel grade 100 ranged from 0.603 to 0.857 indicating that the drug release occurred by anomalous non fickian diffusion kinetics while then value of reference Cardaktin® tablet was measured as 0.125 indicating that these tablets do not follow power law. The dissolution profiles of test formulations were different than that of reference Cardaktin®. This suggests the polymer Ethocel grade 100 can be proficiently incorporated in fabrication and development of once a day controlled release matrix tablets.
authors.affiliation: Faculty of Pharmacy, Gomal University, DI Khan, KPK, Pakistan.
authors.forename: Kamran Ahmad
authors.initials: KA
authors.lastname: Khan
authors.affiliation: Faculty of Pharmacy, Gomal University, DI Khan, KPK, Pakistan; Department of Pharmacy, Quaid-i- Azam University, Islamabad, Pakistan.
authors.forename: Gul Majid
authors.initials: GM
authors.lastname: Khan
authors.affiliation: University College of Pharmacy, University of the Punjab, Lahore, Pakistan. Electronic address: pfarmacist@hotmail.com.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zeeshan Danish
authors.affiliation: Faculty of Pharmacy, Gomal University, DI Khan, KPK, Pakistan.
authors.lastname: Akhlaq
authors.affiliation: Faculty of Pharmacy, Gomal University, DI Khan, KPK, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: Faculty of Pharmacy, Gomal University, DI Khan, KPK, Pakistan.
authors.forename: Fazal
authors.initials: F
authors.lastname: Rehman
authors.affiliation: Department of Pharmacy, Hazara University, Havelian Campus, KPK Pakistan.
authors.forename: Saifullah
authors.initials: S
authors.lastname: Mehsud
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D019808:Losartan / Q000737:chemistry*; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; D002482:Cellulose; D019808:Losartan
keywords: Controlled release; Ethocel grade 100; Losartan Potassium; Matrix tablets