title: Outcome analysis of 215 patients with parotid gland tumors: a retrospective cohort analysis.
abstract: BACKGROUND
  To identify prognostic factors in patients with parotid gland carcinomas who were treated at the Princess Margaret Hospital.
  
  
  METHODS
  Clinical outcome of two hundred fifteen patients with malignancies of the parotid gland was evaluated over a 16-year period.
  
  
  RESULTS
  Two-hundred-fifteen patients with adenoid cystic carcinoma (n = 20), adenocarcinoma (n = 19), acinic cell carcinoma (n = 62), basal cell adenocarcinoma (n = 7), carcinoma-ex-pleomorphic adenoma (n = 18), mucoepidermoid carcinoma (n = 70) and salivary duct carcinoma (n = 19) have been included. The 5- and 10-year overall and disease-free survivals were 80.62%/69.48% and 74.37%/62.42%, respectively. Multivariable analysis showed that age greater than 60 years, advanced pN classification, histopathological grade and the presence of lymphovascular invasion significantly worsened overall and disease-free survival. Univariable analysis revealed periparotid lymph node involvement was associated with decreased overall (p < 0.0001) and disease-free survival (p < 0.0001).
  
  
  CONCLUSIONS
  In addition to age, pN classification, histopathological grade, perineural invasion, and lymphovascular involvement, periparotid lymph node metastasis appears to be an important prognosticator in parotid gland malignancy.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. boban.erovic@meduniwien.ac.at.
authors.forename: Boban M
authors.initials: BM
authors.lastname: Erovic
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. Manish.Shah@utoronto.ca.
authors.forename: Manish D
authors.initials: MD
authors.lastname: Shah
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. guillembruch@yahoo.co.uk.
authors.forename: Guillem
authors.initials: G
authors.lastname: Bruch
authors.affiliation: Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. Meredith.johnston@petermac.org.
authors.forename: Meredith
authors.initials: M
authors.lastname: Johnston
authors.affiliation: Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. Meredith.johnston@petermac.org.
authors.forename: U
authors.initials: U
authors.lastname: Johnston
authors.affiliation: Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. john.kim@rmp.uhn.on.ca.
authors.forename: John
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. brian.osullivan@rmp.uhn.on.ca.
authors.forename: Brian
authors.initials: B
authors.lastname: O'Sullivan
authors.affiliation: Department of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. Bayardo.perez-ordonez@uhn.ca.
authors.forename: Bayardo
authors.initials: B
authors.lastname: Perez-Ordonez
authors.affiliation: Department of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. ilan.weinreb@uhn.ca.
authors.forename: Ilan
authors.initials: I
authors.lastname: Weinreb
authors.affiliation: Department of Biostatistics, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. eatenafu@uhnresearch.ca.
authors.forename: Eshetu G
authors.initials: EG
authors.lastname: Atenafu
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. john.dealmeida@uhn.ca.
authors.forename: John R
authors.initials: JR
authors.lastname: de Almeida
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. patrick.gullane@uhn.ca.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Gullane
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. dale.brown@uhn.ca.
authors.forename: Dale
authors.initials: D
authors.lastname: Brown
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. ralph.gilbert@uhn.ca.
authors.forename: Ralph W
authors.initials: RW
authors.lastname: Gilbert
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. jonathan.irish@uhn.ca.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Irish
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. david.goldstein@uhn.ca.|Princess Margaret Hospital, Wharton Head and Neck Centre, 610 University Avenue, 3rd Floor, Toronto, ON, M5G 2 M9, Canada. david.goldstein@uhn.ca.
authors.forename: David P
authors.initials: DP
authors.lastname: Goldstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D010306:Parotid Gland / Q000473:pathology*; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000556:secondary; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D055815:Young Adult