title: Progression of carotid-artery disease in type 2 diabetic patients: a cohort prospective study.
abstract: In order to assess the progression of carotid-artery disease in type 2 diabetic cohort (n=207 patients), the dynamic change in carotid intima-media thickness (CIMT) and the occurrence of plaques were followed for a period of 31.35±10.59 months. The mean CIMT at the beginning of the study was 0.9178±0.1447 mm, with a maximal value of 1.1210±0.2366 mm. The maximal value of CIMT changed by 0.07 mm/year. Progression of CIMT was noted in 86.8% and its regression in 7.8% of patients. The occurrence of carotid plaques was detected in 41.8% of patients. Multiple regression analysis revealed the maximal value of CIMT to be associated with diastolic blood pressure, despite mean CIMT being predicted by body mass index. The presence of peripheral arterial disease and hypo-high-density lipoproteinemia were found to be predictors for the occurrence of carotid plaques. Our data have clinical implications in predicting risk factors for the progression of carotid-artery disease in type 2 diabetic patients for their appropriate management.
authors.affiliation: Faculty of Medicine, University Cardiology Clinic, Skopje, Macedonia.
authors.forename: Marijan
authors.initials: M
authors.lastname: Bosevski
authors.affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia.
authors.forename: Lily
authors.initials: L
authors.lastname: Stojanovska
mesh_terms: D001794:Blood Pressure; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000175:diagnosis / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis; D018450:Disease Progression; D006801:Humans; D007009:Hypolipoproteinemias / Q000097:blood / Q000150:complications; D008075:Lipoproteins, HDL / Q000097:blood; D058729:Peripheral Arterial Disease / Q000150:complications / Q000503:physiopathology; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D008075:Lipoproteins, HDL
keywords: carotid IMT; progression of atherosclerosis; risk factors; type 2 diabetes