title: Design and Evaluation of a Robust PID Controller for a Fully Implantable Artificial Pancreas.
abstract: Treatment of type 1 diabetes mellitus could be greatly improved by applying a closed-loop control strategy to insulin delivery, also known as an artificial pancreas (AP). In this work, we outline the design of a fully implantable AP using intraperitoneal (IP) insulin delivery and glucose sensing. The design process utilizes the rapid glucose sensing and insulin action offered by the IP space to tune a PID controller with insulin feedback to provide safe and effective insulin delivery. The controller was tuned to meet robust performance and stability specifications. An anti-reset windup strategy was introduced to prevent dangerous undershoot toward hypoglycemia after a large meal disturbance. The final controller design achieved 78% of time within the tight glycemic range of 80-140 mg/dL, with no time spent in hypoglycemia. The next step is to test this controller design in an animal model to evaluate thein vivoperformance.
authors.affiliation: Department of Chemical Engineering, University of California Santa Barbara , Santa Barbara, California 93106-5080, United States.
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Huyett
authors.affiliation: Department of Chemical Engineering, University of California Santa Barbara , Santa Barbara, California 93106-5080, United States.
authors.forename: Eyal
authors.initials: E
authors.lastname: Dassau
authors.affiliation: Department of Chemical Engineering, University of California Santa Barbara , Santa Barbara, California 93106-5080, United States.
authors.forename: Howard C
authors.initials: HC
authors.lastname: Zisser
authors.affiliation: Department of Chemical Engineering, University of California Santa Barbara , Santa Barbara, California 93106-5080, United States.
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Doyle