title: Responses of Spermatogenous Tissue and Mechanisms of Their Development Upon Cytostatic Exposure.
abstract: A decrease in the total number of sperm cells and reduction of spermatogonium population were observed upon cytostatic damage of spermatogenous tissue caused by single paclitaxel administration. It was established that the paclitaxel-induced damage to the testicular tissue is underlain by reduction of its regenerative potential consisting in depletion of regional precursor pool. Changes in functional activity of progenitor cells were caused not only by direct action of paclitaxel, but also by suppression of the secretory function of the tissue microenvironment.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. thav_pharm@mail.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Borovskaya
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: M E
authors.initials: ME
authors.lastname: Poluektova
mesh_terms: D000818:Animals; D060833:Cellular Microenvironment / Q000187:drug effects; D054697:Cytostatic Agents / Q000494:pharmacology*; D008297:Male; D017239:Paclitaxel / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects; D012708:Sertoli Cells / Q000187:drug effects* / Q000502:physiology; D013091:Spermatogenesis / Q000187:drug effects / Q000502:physiology; D013093:Spermatogonia / Q000187:drug effects* / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D013737:Testis / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology
chemical_list: D054697:Cytostatic Agents; D017239:Paclitaxel
keywords: Sertoli cells; paclitaxel; progenitor cells; regenerative medicine; spermatogenous tissue