title: The relationship between essential tremor and Parkinson's disease.
abstract: Essential tremor (ET) and Parkinson's disease (PD) are the two most common tremor disorders encountered in a movement disorders clinic. Although distinct clinical-pathological entities, both disorders may share overlapping features in addition to rest and postural tremor, such as bradykinesia, rigidity, gait and balance impairment and some non-motor signs. A subset of patients may have a combination of long-standing ET with subsequent PD (ET-PD). There are several lines of evidence from clinical, epidemiologic, imaging, genetic and pathologic studies supporting a link between ET and PD, greater than by chance alone. In this review we will discuss the latest data supporting a relationship between ET and PD and the implications for possible pathogenic link and treatment.
authors.affiliation: Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Thenganatt
authors.affiliation: Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA. Electronic address: josephj@bcm.edu.
authors.forename: Joseph
authors.initials: J
authors.lastname: Jankovic
mesh_terms: D000818:Animals; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D020329:Essential Tremor / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009127:Muscle Rigidity / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D010300:Parkinson Disease / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D011187:Posture / Q000502:physiology; D012146:Rest / Q000502:physiology
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins
keywords: Essential tremor; Parkinson's disease; Tremor