title: Pre exchange Albumin Administration in Neonates with Hyperbilirubinemia: A Randomized Controlled Trial.
abstract: OBJECTIVE
  To evaluate the efficacy of pre-exchange transfusion albumin priming in neonates with non-hemolytic hyperbilirubinemia.
  
  
  METHODS
  Single center, randomized controlled trial.
  
  
  METHODS
  Level III Neonatal unit.
  
  
  METHODS
  Fifty healthy term and late preterm neonates with non-hemolytic hyperbilirubinemia requiring exchange transfusion.
  
  
  METHODS
  5 mL/kg of either 20% human albumin (n=23) or 0.9% saline (n=27) infusion one hour prior to exchange transfusion.
  
  
  METHODS
  Post-exchange transfusion phototherapy duration.
  
  
  RESULTS
  The post-exchange transfusion phototherapy duration was not different between albumin and saline groups [Median (IQR): 29 (24-48) h vs. 33 (24-43) h; P=0.76]. The total amount of bilirubin removed during exchange transfusion was also similar [Median (IQR): 34 (28-46) mg vs. 33 (27-38) mg; P=0.46]. Serial changes in total serum bilirubin following exchange transfusion and need for repeat exchange transfusion were comparable between the groups.
  
  
  CONCLUSIONS
  In healthy late preterm and term neonates with non-hemolytic hyperbilirubinemia, priming with 1 g/kg of 20% albumin prior to exchange transfusion is not superior to equi-volume 0.9% saline in reducing post- exchange transfusion phototherapy duration or amount of bilirubin mass removed.
authors.affiliation: Department of Pediatrics, Advanced Pediatrics Centre, PGIMER, Chandigarh, India. Correspondence to: Dr Praveen Kumar, Professor, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India. drpkumarpgi@gmail.com.
authors.forename: Nabaneeta
authors.initials: N
authors.lastname: Dash
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar
authors.forename: Venkataseshan
authors.initials: V
authors.lastname: Sundaram
authors.forename: Savita Verma
authors.initials: SV
authors.lastname: Attri
mesh_terms: D000418:Albumins / Q000008:administration & dosage* / Q000627:therapeutic use; D005078:Exchange Transfusion, Whole Blood / Q000379:methods*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000628:therapy*; D007231:Infant, Newborn; D008517:Phytotherapy
chemical_list: D000418:Albumins