title: Early rescue of interneuron disease trajectory in developmental epilepsies.
abstract: The discovery of over 150 monogenic epilepsies and advances in early genetic diagnoses have launched a search for molecular strategies and developmental timetables to reverse or even prevent the course of these debilitating brain disorders. Orthologous rodent models of key disease genes are providing important examples of the range of targets, and serve as valuable test systems for perinatal therapeutic approaches. While gene-specific analyses of single rare 'orphan' diseases are each narrow in scope, they illuminate downstream pathways converging onto interneurons, and treatments that strengthen inhibition during cortical maturation may provide broad protection against these seemingly disparate gene errors. Several genes, even those linked to malformations, show promise for postnatal correction before the onset of their clinical phenotype.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Meagan S
authors.initials: MS
authors.lastname: Siehr
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: jnoebels@bcm.edu.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Noebels
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002454:Cell Differentiation / Q000235:genetics; D002465:Cell Movement / Q000235:genetics*; D004195:Disease Models, Animal; D018450:Disease Progression; D004827:Epilepsy / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D018507:Gene Expression Regulation, Developmental; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007395:Interneurons / Q000378:metabolism* / Q000502:physiology; D055495:Neurogenesis / Q000235:genetics*; D018377:Neurotransmitter Agents; D010641:Phenotype; D014158:Transcription, Genetic; D019737:Transplants
chemical_list: D006728:Hormones; D018377:Neurotransmitter Agents