title: SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction.
abstract: Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform to enable a high-throughput optimization of a traceless Petasis reaction is described. More than 1800 unique reactions were conducted simultaneously on an array of self-assembled monolayers of alkanethiolates on gold to arrive at optimized conditions, which were then successfully transferred to the solution phase. The utility of this reaction was validated by the efficient synthesis of a variety of di- and trisubstituted allenes.
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Abdallah B
authors.initials: AB
authors.lastname: Diagne
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Shuheng
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Perkowski
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Milan
authors.initials: M
authors.lastname: Mrksich
authors.affiliation: Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
authors.forename: Regan J
authors.initials: RJ
authors.lastname: Thomson
mesh_terms: D000466:Alkadienes / Q000138:chemical synthesis* / Q000737:chemistry; D000473:Alkanes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D006046:Gold / Q000737:chemistry*; D057166:High-Throughput Screening Assays; D015394:Molecular Structure; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000466:Alkadienes; D000473:Alkanes; D013438:Sulfhydryl Compounds; D006046:Gold
keywords: allenes; high-throughput experimentation; mass spectrometry; reaction optimization; self-assembled monolayers