title: Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?
abstract: Glioblastoma Multiforme, the most common and aggressive primary brain tumor, remains incurable despite of the advent of modern surgical and medical treatments. This poor prognosis depends by the recurrence after surgery and intrinsic or acquired resistance to chemotherapy and radiotherapy. Nitric oxide is a small molecule that plays a key roles in glioma pathophysiology. Many researches showing that NO is involved in induction of apoptosis, radiosensitization and chemosensitization. Therefore, NO role, if clarified, may improve the knowledge about this unsolved puzzle called GBM.
authors.affiliation: Department of Neurosurgery, University of Turin, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Altieri
authors.affiliation: Department of Neurosurgery of Brescia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fontanella
authors.affiliation: Department of Neurosurgery, University of Turin, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Agnoletti
authors.affiliation: Department of Neurosurgery of Brescia, Italy.
authors.forename: P P
authors.initials: PP
authors.lastname: Panciani
authors.affiliation: Department of Neurosurgery of Brescia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Spena
authors.affiliation: Department of Neurosurgery, University of Turin, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Crobeddu
authors.affiliation: Department of Neurosurgery, University of Turin, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pilloni
authors.affiliation: Department of Neurosurgery, University of Turin, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Tardivo
authors.affiliation: Department of Neurosurgery, University of Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Lanotte
authors.affiliation: Department of Neurosurgery, University of Turin, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Zenga
authors.affiliation: Department of Neurosurgery, University of Turin, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ducati
authors.affiliation: Department of Neurosurgery, University of Turin, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Garbossa
keywords: Chemotherapy; Glioblastoma; Glioma; NO synthases; Nitric Oxide; Radiotheraypy