title: A Cross-Sectional Investigation of Fatigue, Mucositis, Hand-Foot Syndrome and Dysgeusia in Advanced Renal Cell Carcinoma Treatment: Final Results From the FAMOUS Study.
abstract: Treatment of metastatic renal cell carcinoma can be associated with adverse symptoms. The perception of fatigue, mucositis, hand-foot syndrome, and dysgeusia, and quality of life (QOL) was assessed in 63 oncologists and their patients receiving first-line treatment. Physicians underestimated the severity of the symptoms and the severity correlated with a lower QOL. A consistent assessment of symptoms in routine practice might improve QOL, adherence to treatment, and outcome.
  
  
  BACKGROUND
  The management of symptoms associated with treatment of metastatic renal cell carcinoma (mRCC) is crucial to ensure treatment adherence and outcome. The perception of symptoms can vary between the treating physician and patient, leading to assumptions and subsequent changes in treatment, potentially affecting treatment effectiveness. The aim of the present cross-sectional study was to evaluate the perception of the common symptoms of fatigue, mucositis, hand-foot syndrome, and dysgeusia in patients with mRCC receiving systemic therapies in routine practice.
  
  
  METHODS
  German patients receiving first-line systemic treatment for mRCC and their physicians were independently queried about the incidence and severity of fatigue, mucositis, hand-foot syndrome, and dysgeusia. Patients also completed the Functional Assessment of Cancer Therapy-General questionnaire to assess their quality of life (QOL). The effect of the 4 symptoms on QOL was analyzed using linear regression modeling.
  
  
  RESULTS
  A total of 63 matching questionnaires were completed by both physicians and patients with first-line treatment. The incidence and severity of symptoms differed between the patients and physicians. Patients rated the severity of symptoms significantly higher than did the physicians. A greater severity of symptoms correlated with a lower QOL. In multivariate regression analysis, fatigue adversely affected overall QOL.
  
  
  CONCLUSIONS
  Physicians underestimated the severity of common symptoms in patients with mRCC. The incorporation of patient-reported outcome measures into routine practice might increase awareness of patients' overall QOL and thereby potentially improve treatment adherence. A thorough evaluation of fatigue, its potential underlying causes, and active measures to manage fatigue could potentially improve patients' QOL.
authors.affiliation: Department of Urology, Friedrich-Alexander University, Erlangen, Germany.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Goebell
authors.affiliation: Oncology Outpatient-Centre, Leer, Germany.
authors.forename: Lothar
authors.initials: L
authors.lastname: Müller
authors.affiliation: Group Practice for Oncology, Halle, Saale, Germany.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Hurtz
authors.affiliation: iOMEDICO, Freiburg, Germany.
authors.forename: Michaela
authors.initials: M
authors.lastname: Koska
authors.affiliation: iOMEDICO, Freiburg, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Busies
authors.affiliation: Outpatient-Centre for Interdisciplinary Oncology and Haematology, Freiburg, Germany. Electronic address: marschner@onkologie-freiburg.de.
authors.forename: Norbert
authors.initials: N
authors.lastname: Marschner
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary; D003430:Cross-Sectional Studies; D004408:Dysgeusia / Q000139:chemically induced*; D005221:Fatigue / Q000139:chemically induced*; D005260:Female; D060831:Hand-Foot Syndrome; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D052016:Mucositis / Q000139:chemically induced*; D009367:Neoplasm Staging; D011788:Quality of Life; D057566:Self Report; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: Fatigue; Quality of life; Questionnaires; Registries; Self-report