title: Preliminary results of proton beam therapy combined with weekly cisplatin intra-arterial infusion via a superficial temporal artery for treatment of maxillary sinus carcinoma.
abstract: OBJECTIVE
  This study aimed to evaluate the efficacy and toxicity of proton beam therapy combined with cisplatin intra-arterial infusion via a superficial temporal artery as treatment for maxillary sinus carcinoma.
  
  
  METHODS
  Twenty-six patients with confirmed maxillary sinus carcinoma were enrolled in this study from May 2009 to April 2011. Patients underwent proton beam therapy and intra-arterial infusion chemotherapy with cisplatin.
  
  
  RESULTS
  The median total dose was 70.4 GyE per 32 fractions, and the median dose of cisplatin was 300 mg/body for six cycles of intra-arterial infusion. The 3-year overall survival rate was 58% for all patients (n = 26), 58% for patients with stage T4 disease (n = 12), 57% for patients with <Stage T3 disease (n = 14), 66% for patients with squamous cell carcinoma (n = 15) and 45% for patients with non-squamous cell carcinoma (n = 11). Two patients developed non-hematologic side effects such as Grade 3 radiation dermatitis, one developed osteonecrosis and one developed brain necrosis. Ocular/visual problems occurred in three patients, which included Grade 4 retinopathy and Grade 3 cataract in one and two patients, respectively.
  
  
  CONCLUSIONS
  Proton beam therapy combined with cisplatin intra-arterial infusion administered via a superficial temporal artery appears to be safe and effective for maxillary sinus carcinoma.
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama tatsuya.nakamura@nifty.com.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Azami
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ono
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamaguchi
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama.
authors.forename: Motohisa
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama.
authors.forename: Yoshiomi
authors.initials: Y
authors.lastname: Hatayama
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama.
authors.forename: Iwao
authors.initials: I
authors.lastname: Tsukiyama
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama.
authors.forename: Masato
authors.initials: M
authors.lastname: Hareyama
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kikuchi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama.
authors.forename: Kanako
authors.initials: K
authors.lastname: Takayama
authors.affiliation: Department of Radiation Oncology, Hyogo Ion Beam Medical Center, Tatsuno, Japan.
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Fuwa
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D059248:Chemoradiotherapy / Q000379:methods; D002945:Cisplatin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D061766:Proton Therapy; D016019:Survival Analysis; D013699:Temporal Arteries; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: cisplatin; intra-arterial infusion; maxillary sinus carcinoma; proton beam therapy; superficial artery