title: Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior.
abstract: Fatty acid desaturase genes (FADS1-FADS2) encode desaturases participating in the biosynthesis of long-chain polyunsaturated fatty acids. As long-chain polyunsaturated fatty acids are implicated in major depressive disorder (MDD) and suicide risk, and as both are partly heritable, we studied the association of FADS1-FADS2 polymorphisms with MDD (635 cases, 480 controls) and suicide attempt status (291 attempters, 344 MDD nonattempters). Eighteen FADS-related single-nucleotide polymorphisms were genotyped from Caucasians enrolled in Madrid (n=791) or New York City (n=324) and entered as predictors into logistic regression analyses with diagnostic group or suicide attempt history as outcomes and location and sex as covariates. No associations were observed between any single-nucleotide polymorphisms and diagnosis or attempt status. As statistical power was adequate, we conclude that FADS1-FADS2 genetic variants may not be a common determinant of MDD.
authors.affiliation: Departments of aPsychiatry bRadiology, Columbia University cDepartment of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, New York, New York, USA dDepartment of Psychiatry, IIS Fundación Jiménez-Díaz Madrid eDepartment of Psychiatry, Universidad Autonoma de Madrid fCIBERSAM (Centro de Investigación en Salud Mental), Institute of Health Carlos III of Madrid, Madrid, Spain.
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Sublette
authors.forename: Concepcion
authors.initials: C
authors.lastname: Vaquero
authors.forename: Enrique
authors.initials: E
authors.lastname: Baca-Garcia
authors.forename: Gabriela
authors.initials: G
authors.lastname: Pachano
authors.forename: Yung-Yu
authors.initials: YY
authors.lastname: Huang
authors.forename: Maria A
authors.initials: MA
authors.lastname: Oquendo
authors.forename: J John
authors.initials: JJ
authors.lastname: Mann
mesh_terms: D000328:Adult; D000090943:Delta-5 Fatty Acid Desaturase; D003865:Major Depressive Disorder / Q000235:genetics*; D044943:Fatty Acid Desaturases / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D009518:New York; D020641:Polymorphism, Single Nucleotide; D016728:Self-Injurious Behavior / Q000235:genetics*; D013030:Spain; D013406:Suicide, Attempted; D044465:White People; D055815:Young Adult
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human; C533241:FADS2 protein, human