title: Role of Indocyanine Green in Sentinel Node Mapping in Gynecologic Cancer: Is Fluorescence Imaging the New Standard?
abstract: Sentinel lymph node biopsy has proven safe and feasible in a number of gynecologic cancers such as vulvar cancer, cervical cancer, and endometrial cancer. The proposed aim of lymphatic mapping and sentinel node identification is to decrease the associated morbidity of a complete lymphadenectomy, particularly the rate of lymphedema, while also increasing the detection of small tumor deposits in the node. Different tracers have been shown to be useful, including technetium-99 and blue dye, with a detection reported in 66% to 86%. Recently, there has been increasing interest in the use of fluorescent dies such as indocyanine green (ICG). In this report we provide a review of the existing literature regarding the use of ICG in cervical or endometrial cancer with the goal to provide details on its utility and compare it with other tracers.
authors.affiliation: Department of Gynecology, British Hospital of Buenos Aires, Buenos Aires, Argentina.
authors.forename: María Cecilia
authors.initials: MC
authors.lastname: Darin
authors.affiliation: Department of Obstetrics and Gynecology, Universitary Hospital of Móstoles, Madrid, Spain.
authors.forename: Natalia Rodriguez
authors.initials: NR
authors.lastname: Gómez-Hidalgo
authors.affiliation: Division of Surgery, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Shannon N
authors.initials: SN
authors.lastname: Westin
authors.affiliation: Division of Surgery, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Pamela T
authors.initials: PT
authors.lastname: Soliman
authors.affiliation: Division of Surgery, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Pedro F
authors.initials: PF
authors.lastname: Escobar
authors.affiliation: Division of Surgery, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Michael
authors.initials: M
authors.lastname: Frumovitz
authors.affiliation: Division of Surgery, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: peramire@mdanderson.org.
authors.forename: Pedro T
authors.initials: PT
authors.lastname: Ramirez
mesh_terms: D004396:Coloring Agents; D016889:Endometrial Neoplasms / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology*; D006801:Humans; D007208:Indocyanine Green; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D061848:Optical Imaging; D021701:Sentinel Lymph Node Biopsy / Q000379:methods* / Q000592:standards*; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D014594:Uterine Neoplasms / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green
keywords: Indocyanine green; Laparoscopy; Lymphatic mapping; Robotics