title: Elevated Vibration Perception Thresholds in CIDP Patients Indicate More Severe Neuropathy and Lower Treatment Response Rates.
abstract: BACKGROUND
  Vibration perception threshold (VPT) examination using a neurothesiometer provides objective, sensitive and specific information, and has been utilized mainly in patients with diabetic polyneropathy.
  
  
  OBJECTIVE
  Explore the utility of VPT examination in CIDP patients.
  
  
  METHODS
  CIDP subjects attending the Neuromuscular clinic between 01/2013 and 12/2014 were evaluated. Demographic data, clinical history, physical examination, VPT values, and electrophysiologic data from their charts were extracted.
  
  
  RESULTS
  70 charts were reviewed. 55 CIDP patients had elevated VPT, associated with higher frequency of abnormal sensory testing for various modalities (92.7% vs. 46.7%, p<0.0001), lower sensory and motor amplitudes and reduced conduction velocities on nerve conduction studies, and lower treatment response rates (54% vs. 93%, p = 0.01).
  
  
  CONCLUSIONS
  VPT examination is a simple tool, which is a reliable and sensitive measure not only for diabetic neuropathy, but also for CIDP. Moreover, in CIDP, elevated VPT values are also associated with lower treatment response rates.
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Alon
authors.initials: A
authors.lastname: Abraham
authors.affiliation: Department of Neurology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Hana
authors.initials: H
authors.lastname: Albulaihe
authors.affiliation: Department of Neurology, King Fahad Hospital of the University, University of Dammam, Dammam, Saudi Arabia.
authors.forename: Majed
authors.initials: M
authors.lastname: Alabdali
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Qrimli
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Ari
authors.initials: A
authors.lastname: Breiner
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Carolina
authors.initials: C
authors.lastname: Barnett
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Hans D
authors.initials: HD
authors.lastname: Katzberg
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai, Hospital and Lunenfeld Tanenbaum Research Institute, University of Toronto, Toronto, Canada.
authors.forename: Leif E
authors.initials: LE
authors.lastname: Lovblom
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai, Hospital and Lunenfeld Tanenbaum Research Institute, University of Toronto, Toronto, Canada.
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Perkins
authors.affiliation: Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
authors.forename: Vera
authors.initials: V
authors.lastname: Bril
mesh_terms: D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010465:Perception; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000150:complications*; D011379:Prognosis; D012684:Sensory Thresholds; D012720:Severity of Illness Index; D014732:Vibration