title: L-Amino Acid Based Urea-Tertiary Amine-Catalyzed Chemoselective and Asymmetric Stereoablative Carboxylation of 3-Bromooxindoles with Malonic Acid Half Thioesters.
abstract: An L-amino acid based urea-tertiary amine-catalyzed enantioselective stereoablative carboxylation of 3-bromooxindoles with malonic acid half thioesters (MAHTs) and diverse commercially available carboxylic acids has been developed. A series of valuable 3-substituted 3-hydroxy-2-oxindoles were obtained in high enantioselectivities (up to 93% ee). This chemoselective reaction represents the first example of MAHTs as carboxylating agents.
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, P. R. China , 475004.
authors.forename: Xiangbin
authors.initials: X
authors.lastname: Bai
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, P. R. China , 475004.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Division of Chemistry and Biological Chemistry, Nanyang Technological University , 21 Nanyang Link, 637371, Singapore.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Division of Chemistry and Biological Chemistry, Nanyang Technological University , 21 Nanyang Link, 637371, Singapore.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Ye
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, P. R. China , 475004.
authors.forename: Gao
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, P. R. China , 475004.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, P. R. China , 475004.|Division of Chemistry and Biological Chemistry, Nanyang Technological University , 21 Nanyang Link, 637371, Singapore.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Jiang