title: A New Absorbable Synthetic Substitute With Biomimetic Design for Dural Tissue Repair.
abstract: Dural repair products are evolving from animal tissue-derived materials to synthetic materials as well as from inert to absorbable features; most of them lack functional and structural characteristics compared with the natural dura mater. In the present study, we evaluated the properties and tissue repair performance of a new dural repair product with biomimetic design. The biomimetic patch exhibits unique three-dimensional nonwoven microfiber structure with good mechanical strength and biocompatibility. The animal study showed that the biomimetic patch and commercially synthetic material group presented new subdural regeneration at 90 days, with low level inflammatory response and minimal to no adhesion formation detected at each stage. In the biological material group, no new subdural regeneration was observed and severe adhesion between the implant and the cortex occurred at each stage. In clinical case study, there was no cerebrospinal fluid leakage, and all the postoperation observations were normal. The biomimetic structure and proper rate of degradation of the new absorbable dura substitute can guide the meaningful reconstruction of the dura mater, which may provide a novel approach for dural defect repair.
authors.affiliation: Department of Neurosurgery, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Bio-Manufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, China.
authors.forename: Tao
authors.identifier: http://orcid.org/0000-0001-5362-8588
authors.initials: T
authors.lastname: Xu
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou, China.
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Bio-Manufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, China.
authors.forename: Kunxue
authors.initials: K
authors.lastname: Deng
authors.affiliation: School of Bioscience & Bioengineering, South China University of Technology, Guangzhou, China.
authors.forename: Man
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Zhujiang Hospital, South Medical University, Guangzhou, China.
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Ke
authors.affiliation: Department of Neurosurgery, Zhujiang Hospital, South Medical University, Guangzhou, China.
authors.forename: Chengyi
authors.initials: C
authors.lastname: Luo
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
authors.forename: Tun
authors.initials: T
authors.lastname: Yuan
authors.affiliation: Department of Neurosurgery, University Medical Centre Mainz, Johannes Gutenberg University of Mainz, Mainz, Germany.
authors.forename: Ali
authors.initials: A
authors.lastname: Ayyad
mesh_terms: D001672:Biocompatible Materials; D032701:Biomimetics; D004388:Dura Mater / Q000502:physiology*; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials
keywords: Absorbable; Biomimetic; Dural repair; Synthetic