title: [Effects of moxa smoke with different concentrations on expression of SOD and MDA in lung and serum of rats].
abstract: OBJECTIVE
  To observe the effects of intervention of moxa smoke with different concentrations on superoxide dismutase (SOD) and malondialdehyde (MDA) in serum and lung of male rats, so as to explore the safety concentration of moxa smoke.
  
  
  METHODS
  A total of 32 Wistar male rats were randomly divided into a control group, a low-concentration group, a moderate-concentration group and a high-concentration group, 8 rats in each one. All the rats were exposed in the full-automatic toxicant exposure cabinet, and the overshadow of moxa smoke was set at 0%, 10%, 40% and 70%, respectively. Each rat was exposed for 20 min per day. After 26 weeks, the activities of SOD and content of MDA in serum, lung organ and bronchoalveolar lavage fluid were tested.
  
  
  RESULTS
  Compared with the control group, the activities of serum SOD in the high-concentration group were reduced (P< 0. 05), but those in the low-concentration group and moderate-concentration group were not significantly different (both P>0. 05). Compared with the control group, the content of serum MDA in the low-concentration group, moderate-concentration group and high-concentration group was increased insignificantly (all P>0. 05). There were no significant differences regarding activities of SOD and content of MDA in lung organ and bronchoalveolar lavage fluid among each moxa smoke group (all P>0. 05).
  
  
  CONCLUSIONS
  There is no obvious toxic reaction in the low-concentration group and moderate-concentration group; in the high-concentration group the antioxidant ability is damaged due to long-term exposure.
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Baixiao
authors.initials: B
authors.lastname: Zhao
authors.forename: Tonghua
authors.initials: T
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Hai
authors.initials: H
authors.lastname: Hu
authors.forename: Jia
authors.initials: J
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Cai
authors.forename: Maoxiang
authors.initials: M
authors.lastname: Zhu
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Yang
authors.forename: Xiujie
authors.initials: X
authors.lastname: Pan
authors.forename: Hua
authors.initials: H
authors.lastname: Bai
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Juntian
authors.initials: J
authors.lastname: Liu
authors.forename: Chang
authors.initials: C
authors.lastname: Huang
authors.forename: Yaomeng
authors.initials: Y
authors.lastname: Liu
authors.forename: Lue
authors.initials: L
authors.lastname: Ha
mesh_terms: D000818:Animals; D019306:Artemisia / Q000737:chemistry; D008168:Lung / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism*; D009071:Moxibustion; D051381:Rats; D017208:Rats, Wistar; D012906:Smoke / Q000032:analysis*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*
chemical_list: D012906:Smoke; D008315:Malondialdehyde; D013482:Superoxide Dismutase