title: Association of NOTCH with different microRNAs in head and neck cancer.
abstract: Head and neck cancer is the sixth most common cancer worldwide with an alarming increase in Asian countries. Overwhelmingly increasing cell culture and preclinical studies are identifying wide ranging mechanisms which are instrumental in disease development, progression and resistance against different therapeutics. The scientists are unable to differentiate whether expressional mutation is a cause or a consequence of some other alterations occurring in the body. We partition this review into how NOTCH1 and p16 contribute in cancer development and how microRNAs quantitatively control NOTCH1 expression. Future studies must converge on identification of miRNAs which negatively regulate p16 and targeted inhibition of p16 targeting miRNAs will be helpful in inhibiting tumor growth, cell proliferation and induction of apoptosis. Detailed mechanistic insights related to miRNA mediated Notch regulation will also be useful in delivery of tumor suppressor miRNAs or mimics to effectively inhibit cancer.
authors.affiliation: Fatima Jinnah Women University Environmental Sciences Department Rawalpindi Pakistan nosheenmasood&commat;hotmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Masood
authors.affiliation: GCU Department of Chemistry Lahore Pakistan.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Qureshi
authors.affiliation: Fatima Jinnah Women University Environmental Sciences Department Rawalpindi Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Yasmin
mesh_terms: D000818:Animals; D019941:Cyclin-Dependent Kinase Inhibitor p16; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D051881:Receptor, Notch1 / Q000235:genetics / Q000378:metabolism*
chemical_list: C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D035683:MicroRNAs; C497761:NOTCH1 protein, human; D009363:Neoplasm Proteins; D051881:Receptor, Notch1