title: Influences of keratinocyte growth factor - mesenchymal stem cells on chronic liver injury in rats.
abstract: To study the effects of keratinocyte growth factor (KGF) modified umbilical cord mesenchymal stem cells (MSC) on chronic liver injury in rats, adenovirus carrying human KGF gene (Ad-KGF) was used. Rat liver injury model was established by subcutaneous injection of CCl4- olive oil solution; 56 male Wistar rats were randomly divided into normal control, model, MSC, KGF, and KGF/MSC groups. Of all three treatments, KGF/MSC had the most obvious therapeutic effects on liver injury, and cell injections did not cause adverse reaction. The experiment provides new data for clinical research of KGF/MSC and possible methods for liver injury treatment.
authors.affiliation: a Anhui Huien Biotech Co., Ltd. , Anhui , China.|b Institute of Advanced Technology, University of Science and Technology of China , Anhui , China.
authors.forename: Zhengliang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: c Cancer Epigenetics Program, Anhui Cancer Hospital , Anhui , China.
authors.forename: Youguang
authors.initials: Y
authors.lastname: Pu
authors.affiliation: b Institute of Advanced Technology, University of Science and Technology of China , Anhui , China.
authors.forename: Qingsong
authors.initials: Q
authors.lastname: Pan
authors.affiliation: b Institute of Advanced Technology, University of Science and Technology of China , Anhui , China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Xu
authors.affiliation: b Institute of Advanced Technology, University of Science and Technology of China , Anhui , China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Yan
mesh_terms: D000256:Adenoviridae; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism / Q000628:therapy; D002908:Chronic Disease; D051523:Fibroblast Growth Factor 7 / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014161:Transduction, Genetic
chemical_list: C496453:FGF7 protein, human; D051523:Fibroblast Growth Factor 7
keywords: CCl4; chronic liver injury; keratinocyte growth factor; mesenchymal stem cell