title: Emergent treatments based on the pathophysiology of bipolar disorder: A selective review.
abstract: Bipolar disorder is a chronic psychiatric disorder that is a cause of significant symptomatology even in the setting of optimal treatment. Most current treatments are developed from serendipity, and not based on known pathophysiology. In this review we examine a number of somatic and pharmacologic therapies that are poised to become part of the armamentarium of interventions to treat bipolar illness. As a group, these interventions are derived from a growing understanding of the biological underpinnings of bipolar disorders. We will look at emergent treatments based on our understanding of the molecular biology, neuroanatomy, and the genetics of bipolar disorder.
authors.affiliation: Department of Psychiatry, Beth-Israel Deaconess Medical Center, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States. Electronic address: robrady@bidmc.harvard.edu.
authors.forename: Roscoe O
authors.initials: RO
authors.lastname: Brady
authors.affiliation: Department of Psychiatry, Beth-Israel Deaconess Medical Center, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.
authors.forename: Matcheri
authors.initials: M
authors.lastname: Keshavan
mesh_terms: D001526:Behavioral Symptoms / Q000175:diagnosis / Q000628:therapy*; D001714:Bipolar Disorder / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D020746:Calcium Channels, L-Type / Q000235:genetics; D006801:Humans; D010597:Pharmacogenetics; D011611:Psychosomatic Medicine / Q000379:methods; D011619:Psychotropic Drugs / Q000378:metabolism / Q000494:pharmacology
chemical_list: C079146:CACNA1C protein, human; D020746:Calcium Channels, L-Type; D011619:Psychotropic Drugs
keywords: Bipolar disorder; Depression; Genetics; Mania; TMS