title: A new lumazine peptide penilumamide E from the fungus Aspergillus terreus.
abstract: A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2-14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values of 2.83 μg/mL. Compounds 4 and 6 showed weak cytotoxicity against cholangiocarcinoma (CCA) cell lines. In addition, 4 and 11 exhibited weak cytotoxicity against human hepatoma cell line.
authors.affiliation: a Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Natural Products Research Unit, Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Boonyanoot
authors.initials: B
authors.lastname: Chaiyosang
authors.affiliation: a Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Natural Products Research Unit, Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
authors.affiliation: b Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Material Chemistry Research Center, Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Jaursup
authors.initials: J
authors.lastname: Boonmak
authors.affiliation: b Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Material Chemistry Research Center, Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Sujittra
authors.initials: S
authors.lastname: Youngme
authors.affiliation: c Faculty of Medicine, Department of Pharmacology , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Veerapol
authors.initials: V
authors.lastname: Kukongviriyapan
authors.affiliation: d Faculty of Agricultural Technology, Department of Plant Production Technology , King Mongkut's Institute of Technology Ladkrabang , Bangkok , Thailand.
authors.forename: Kasem
authors.initials: K
authors.lastname: Soytong
authors.affiliation: a Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry , Natural Products Research Unit, Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects; D011621:Pteridines / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization; D014961:X-Ray Diffraction
chemical_list: D000903:Antibiotics, Antineoplastic; D000962:Antimalarials; D009842:Oligopeptides; D011621:Pteridines; C000611782:penilumamide E; C008297:lumazine
keywords: Aspergillus terreus; antimalarial; butyrolactone; epi-aszonalenin A; lumazine peptide; penilumamide E