title: Early application of related SCT might improve clinical outcome in adult T-cell leukemia/lymphoma.
abstract: Allogeneic hematopoietic SCT (allo-HSCT) is a curative treatment for aggressive adult T-cell leukemia/lymphoma (ATLL). Considering the dismal prognosis associated with conventional chemotherapies, early application of allo-HSCT might be beneficial for patients with ATLL. However, no previous study has addressed the optimal timing of allo-HSCT from related donors. Hence, to evaluate the impact of timing of allo-HSCT for patients with ATLL, we retrospectively analyzed data from patients with ATLL who received an allo-HSCT from a related donor. The median age was 52 years. Patients were grouped according to the interval from diagnosis to allo-HSCT: early transplant group, <100 days, n=72; late transplant group, ⩾100 days, n=428. The corresponding constituents of disease status were not statistically different between the two groups (P=0.11). The probability of OS in the early transplant group was significantly higher than that in the late transplant group (4-year OS, 49.3% vs 31.2%). Multivariate analysis revealed that late allo-HSCT was an unfavorable prognostic factor for OS (hazard ratio, 1.46; 95% confidence interval (CI), 1.01-2.11; P=0.04). Despite the limitations of a retrospective study, it might be acceptable to consider early application of allo-HSCT for ATLL.
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fuji
authors.affiliation: First Department of Internal Medicine, Ehime University Hospital, Ehime, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fujiwara
authors.affiliation: Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Nakano
authors.affiliation: Department of Hematology, Toranomon Hospital Kajigaya, Kanagawa, Japan.
authors.forename: A
authors.identifier: http://orcid.org/0000-0002-9653-6170
authors.initials: A
authors.lastname: Wake
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.affiliation: Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hidaka
authors.affiliation: Department of Hematology, Sasebo City General Hospital, Nagasaki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Moriuchi
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.affiliation: Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Uike
authors.affiliation: Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Nagasaki University Hospital, Nagasaki, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Taguchi
authors.affiliation: Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Eto
authors.affiliation: Second Department of Internal Medicine, Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, University Hospital, University of the Ryukyus, Okinawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tomoyose
authors.affiliation: Department of Hematology/Oncology, Kyoto University Hospital, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Department of Haematology, Heart-Life Hospital, Okinawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Yamanoha
authors.affiliation: Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ichinohe
authors.affiliation: Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.|Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Atsuta
authors.affiliation: Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Utsunomiya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D064591:Allografts; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D013997:Time Factors