title: Role of Interleukin-4, Interleukin-10, and Tumor Necrosis Factor-α Polymorphic Genes in the Pathogenesis of Occupational Allergic Dermatoses.
abstract: Study of polymorphic genes of pro- and anti-inflammatory cytokines (IL-4, IL-10, TNF-α) in patients with occupational allergic dermatoses showed significantly higher frequency of polymorphic variants of cytokine genes IL4 C589T, IL10 C819T, IL10 G1082A, IL10 C592A, and TNF G308A in comparison with the population control. The presence of homozygous variant IL10 G1082A--AA in 80% cases characterizes early disease development, i.e. within 3 years after the first exposure to the occupational factor.
authors.affiliation: Research Institute of Labor Medicine, Moscow, Russia. lpkuzmina@mail.ru.
authors.forename: L P
authors.initials: LP
authors.lastname: Kuz'mina
authors.affiliation: Research Institute of Labor Medicine, Moscow, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Izmerova
authors.affiliation: Research Institute of Labor Medicine, Moscow, Russia.
authors.forename: M M
authors.initials: MM
authors.lastname: Kolyaskina
mesh_terms: D019943:Amino Acid Substitution; D001249:Asthma / Q000453:epidemiology / Q000235:genetics; D016022:Case-Control Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics*; D004485:Eczema / Q000453:epidemiology / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D009784:Occupational Diseases / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: C508609:IL10 protein, human; C508598:IL4 protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4
keywords: cytokines; individual liability; occupational allergic dermatoses