title: Opsoclonus-myoclonus syndrome after adenovirus infection.
abstract: Autoimmune and paraneoplastic movement disorders are rare in childhood. Diagnosis often relies on clinical manifestations and clinicians' recognition. A 22-month-old girl at onset of opsoclonus-myoclonus syndrome (OMS) was followed for 8 years. Adenovirus (type C subtype 3) infection coincided with manifestation. Data on treatment, imaging and follow-up are provided. In the spinal fluid, elevated anti-rubella antibodies and oligoclonal bands were detected. An autoimmune process affecting mainly cerebellar neurons was revealed immunohistochemically. Moderately intense long-term immunosuppressive therapy resulted in a favorable clinical outcome. A video demonstrated severe OMS manifestations at onset, followed by nearly complete recovery after treatment. We describe the association of a parainfectious OMS and adenovirus infection; laboratory results indicate a non-specific humoral process affecting mainly cerebellar neurons. Our video documentation will aid to recognize this rare movement disorder and to initiate early treatment.
authors.affiliation: Department of Women and Child Health, Hospital for Children and Adolescents, University Hospitals, University of Leipzig, Liebigstr 20a, 04103 Leipzig, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Syrbe
authors.affiliation: Department of Women and Child Health, Hospital for Children and Adolescents, University Hospitals, University of Leipzig, Liebigstr 20a, 04103 Leipzig, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Merkenschlager
authors.affiliation: Department of Women and Child Health, Hospital for Children and Adolescents, University Hospitals, University of Leipzig, Liebigstr 20a, 04103 Leipzig, Germany.
authors.forename: Matthias K
authors.initials: MK
authors.lastname: Bernhard
authors.affiliation: Paul Flechsig Institute for Brain Research, University of Leipzig, Liebigstr. 19, 04103 Leipzig, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Grosche
authors.affiliation: Institute of Virology, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany.
authors.forename: Uwe Gerd
authors.initials: UG
authors.lastname: Liebert
authors.affiliation: Section Paediatric Radiology, Department of Imaging and Radiotherapy, University of Leipzig, 04103 Leipzig, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hirsch
authors.affiliation: Paul Flechsig Institute for Brain Research, University of Leipzig, Liebigstr. 19, 04103 Leipzig, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Härtig
keywords: Ataxia; Autoimmune; Children; Encephalopathy; Movement disorder