title: Use of functional genomics to understand replication deficient poxvirus-host interactions.
abstract: High-throughput genomics technologies are currently being used to study a wide variety of viral infections, providing insight into which cellular genes and pathways are regulated after infection, and how these changes are related, or not, to efficient elimination of the pathogen. This article will focus on how gene expression studies of infections with non-replicative poxviruses currently used as vaccine vectors provide a global perspective of the molecular events associated with the viral infection in human cells. These high-throughput genomics approaches have the potential to lead to the identification of specific new properties of the viral vector or novel cellular targets that may aid in the development of more effective pox-derived vaccines and antivirals.
authors.affiliation: Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma, E-28029 Madrid, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Fernández-Escobar
authors.affiliation: Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma, E-28029 Madrid, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Baldanta
authors.affiliation: Department of Immunology and Oncology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus Universidad Autónoma, E-28049 Madrid, Spain.
authors.forename: Hugh
authors.initials: H
authors.lastname: Reyburn
authors.affiliation: Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma, E-28029 Madrid, Spain. Electronic address: susana.guerra@uam.es.
authors.forename: Susana
authors.initials: S
authors.lastname: Guerra
mesh_terms: D000818:Animals; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D054884:Host-Pathogen Interactions; D006801:Humans; D011212:Poxviridae / Q000235:genetics* / Q000502:physiology; D011213:Poxviridae Infections / Q000235:genetics* / Q000378:metabolism / Q000821:virology*; D014779:Virus Replication
keywords: Genomic; Microarrays; Poxvirus; Vaccines