title: [Safety Evaluation of Rare Sugar Syrup: Single-dose Oral Toxicity in Rats, Reverse Mutation Assay, Chromosome Aberration Assay, and Acute Non-Effect Level for Diarrhea of a Single Dose in Humans].
abstract: The safety of rare sugar syrup obtained from high-fructose corn syrup under slightly alkaline conditions was studied. Mutagenicity of rare sugar syrup was assessed by a reverse mutation assay using Salmonella typhimurium and Escherichia coli, and an in vitro chromosomal aberration assay using Chinese hamster lung cell line (CHL/IU). No mutagenicity of rare sugar syrup was detected under these experimental conditions. Oral administration of single dose (15,000 mg/kg) of rare sugar syrup to rats caused no abnormalities, suggesting no adverse effect of rare sugar syrup. In humans, the acute non-effect level of rare sugar syrup for causing diarrhea was estimated as 0.9 g/kg body weight as dry solid base in both males and females.
authors.affiliation: Matsutani Chemical Industry Co., Ltd., Research & Development.
authors.forename: Takako
authors.initials: T
authors.lastname: Yamada
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Iida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takamine
authors.forename: Noriko
authors.initials: N
authors.lastname: Hayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okuma
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000139:chemically induced*; D006224:Cricetinae; D003412:Cricetulus; D003967:Diarrhea / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D005260:Female; D059022:Food Safety; D066248:High Fructose Corn Syrup / Q000008:administration & dosage / Q000009:adverse effects* / Q000633:toxicity*; D006801:Humans; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods*; D009154:Mutation / Q000187:drug effects*; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics*
chemical_list: D066248:High Fructose Corn Syrup