title: Acne in Klinefelter Syndrome-46XY/47XXY Mosaicism?
abstract: Klinefelter syndrome (KFS) is the most common non-heritable sex chromosome anomaly caused by nondisjunction during cell division and contains two or more X chromosomes. More than two third of all cases are homogenous (47XXY) and the remaining are mosaic (46XY/47XXY). Lower limb ulcers are frequently observed and attributed to impaired fibrinolysis. A case of KFS with post acne scars and leg ulcers is presented. The rarity of acne in this syndrome is explained by the phenomenon of mosaicism.
authors.affiliation: Department of Dermatology, PSG Hospitals and PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
authors.forename: Chembolli
authors.initials: C
authors.lastname: Lakshmi
authors.affiliation: Department of Dermatology, PSG Hospitals and PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
authors.forename: Selvaraj
authors.initials: S
authors.lastname: Swarnalakshimi
keywords: Acne; Klinefelter syndrome; mosaicism