title: [Current treatments for corneal neovascularization].
abstract: The extension of blood vessels into the normally avascular stroma defines corneal neovascularization. Though this phenomenon, pathophysiological and clinical features are well characterized, therapeutic modalities have been hindered by a lack of safe, efficacious and non-controversial treatments. In this literature review, we focus on available therapeutic options in light of recent evidence provided by animal and clinical studies. First, this review will focus on pharmacological treatments that target angiogenesis. The low cost and market availability of bevacizumab make it the first anti-angiogenic therapy choice, and it has demonstrable efficacy in reducing corneal neovascularization when administered topically or subconjunctivally. However, novel anti-angiogenic molecules targeting the intracellular pathways of angiogenesis (siRNA, antisense oligonucleotides) provide a promising alternative. Laser therapy (direct photocoagulation or photo-dynamic therapy) and fine needle diathermy also find a place in the treatment of stabilized corneal neovascularization alone or in association with anti-angiogenic therapy. Additionally, ocular surface reconstruction using amniotic membrane graft or limbal stem cell transplantation is essential when corneal neovascularization is secondary to primary or acquired limbal deficiency.
authors.affiliation: Clinique ophtalmologique François-Chénieux, 18, rue du Général-Catroux, 87039 Limoges cedex, France; Institut de recherche et d'innovation en sciences de la vision (IRIS-Vision), 18, rue du Général-Catroux, 87039 Limoges cedex, France. Electronic address: yohan.benayoun@gmail.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Benayoun
authors.affiliation: Clinique ophtalmologique François-Chénieux, 18, rue du Général-Catroux, 87039 Limoges cedex, France; Institut de recherche et d'innovation en sciences de la vision (IRIS-Vision), 18, rue du Général-Catroux, 87039 Limoges cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Petellat
authors.affiliation: Service d'ophtalmologie, hôpital Dupuytren, CHU de Limoges, 87042 Limoges cedex, France.
authors.forename: O
authors.initials: O
authors.lastname: Leclerc
authors.affiliation: Service d'ophtalmologie, hôpital Dupuytren, CHU de Limoges, 87042 Limoges cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Dost
authors.affiliation: Service de radiologie, hôpital Pellegrin, CHU de Bordeaux, 33000 Bordeaux, France.
authors.forename: B
authors.initials: B
authors.lastname: Dallaudière
authors.affiliation: Baylor Scott & White Memorial Hospital, Texas A&M University, Texas, États-Unis.
authors.forename: C
authors.initials: C
authors.lastname: Reddy
authors.affiliation: Service d'ophtalmologie, hôpital Dupuytren, CHU de Limoges, 87042 Limoges cedex, France.
authors.forename: P-Y
authors.initials: PY
authors.lastname: Robert
authors.affiliation: Clinique ophtalmologique François-Chénieux, 18, rue du Général-Catroux, 87039 Limoges cedex, France; Institut de recherche et d'innovation en sciences de la vision (IRIS-Vision), 18, rue du Général-Catroux, 87039 Limoges cedex, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Salomon
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016510:Corneal Neovascularization / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D016039:Corneal Transplantation; D004564:Electrocoagulation / Q000295:instrumentation; D015316:Genetic Therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017075:Laser Coagulation; D010778:Photochemotherapy; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D020533:Angiogenesis Inhibitors; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D047428:Protein Kinase Inhibitors
keywords: Angiogenesis; Angiogenèse; Anti-VEGF; Corneal grafts; Corneal neovascularization; Greffes de cornée; Herpetic keratitis; Kératite herpétique; Néovascularisation cornéenne