title: [SAFETY AND EFFICACY OF ONE-YEAR RUSH SUBCUTANEOUS IMMUNOTHERAPY IN JAPANESE CHILDREN, USING HOUSE DUST EXTRACT].
abstract: BACKGROUND
  In recent years there have been few reports on the effects of immunotherapy on bronchial asthma (BA) and allergic rhinitis (AR) in Japanese children.
  
  
  OBJECTIVE
  To investigate the safety and efficacy of house dust extract immunotherapy for one year.
  
  
  METHODS
  Thirty-five children with AR and BA were subjected to rush immunotherapy with house dust extract. Systemic reactions were counted to evaluate safety. BA medication score and AR symptom-medication score were recorded.
  
  
  RESULTS
  Three patients (8.3% of all patients) experienced 6 systemic reactions (0.15% of doses). BA medication score decreased from 567 to 325 (a reduction rate of 43%). AR symptom-medication score improved from 5.1 to 2.9 (a reduction rate of 43%).
  
  
  CONCLUSIONS
  Rush immunotherapy with house dust extract is safe and effective for Japanese children.
authors.affiliation: Department of Pediatrics, Kobe City Medical Center General Hospital.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Ikuo
authors.initials: I
authors.lastname: Okafuji
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Narabayashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Tsuruta
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic / Q000379:methods*; D004391:Dust / Q000276:immunology*; D006801:Humans; D008297:Male; D065631:Rhinitis, Allergic / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D004391:Dust