title: Bridging small interfering RNA with giant therapeutic outcomes using nanometric liposomes.
abstract: The scope of RNAi based therapeutics is unquestionable. However, if we dissect the current trend of clinical trials for afore mentioned drug class, some stark trends appear: 1) naked siRNA only exerts influence in topical mode whilst systemic delivery requires a carrier and 2) even after two decades of extensive efforts, not even a single siRNA containing product is commercially available. It was therefore felt that a perspective simplifying the unique intricacies of working with a merger of siRNA and liposomes from a pharmaceutical viewpoint could draw the attention of a wider array of interested researchers. We begin from the beginning and attempt to conduit the gap between theoretical logic and experimental/actual constraints. This, in turn could stimulate the next generation of investigators, gearing them to tackle the conundrum, which is siRNA delivery.
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Yuvraj
authors.initials: Y
authors.lastname: Singh
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Tomar
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Shariq
authors.initials: S
authors.lastname: Khan
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Jaya Gopal
authors.initials: JG
authors.lastname: Meher
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Pawar
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Kavit
authors.initials: K
authors.lastname: Raval
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Komal
authors.initials: K
authors.lastname: Sharma
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Pankaj K
authors.initials: PK
authors.lastname: Singh
authors.affiliation: Amity Institute of Pharmacy, Amity University, Lucknow, UP 226028, India.
authors.forename: Mohini
authors.initials: M
authors.lastname: Chaurasia
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: B
authors.initials: B
authors.lastname: Surendar Reddy
authors.affiliation: Pharmaceutics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India. Electronic address: manish_chourasia@cdri.res.in.
authors.forename: Manish K
authors.initials: MK
authors.lastname: Chourasia
mesh_terms: D000818:Animals; D011992:Endosomes / Q000378:metabolism; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D006801:Humans; D008055:Lipids / Q000737:chemistry* / Q000276:immunology; D008081:Liposomes; D053758:Nanoparticles; D034622:RNA Interference; D020871:RNA Stability; D034741:RNA, Small Interfering / Q000737:chemistry / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D000067492:RNAi Therapeutics / Q000379:methods*
chemical_list: D008055:Lipids; D008081:Liposomes; D034741:RNA, Small Interfering
keywords: Cationic lipids; Clinical trials; Endosomal escape; Lipoplexes; Liposomes; siRNA; siRNA delivery; siRNA selection