title: Phenytoin Induced Cutaneous B Cell Pseudolymphoma.
abstract: Cutaneous pseudolymphomas are benign lymphoproliferative processes mimicking lymphomas clinically and histologically. One of the precipitating factors for pseudolymphoma is drugs like anticonvulsants, antidepressants and angiotensin-converting enzyme inhibitors. According to existing literature phenytoin-induced cutaneous pseudolymphomas are usually T-cell predominant. Most often withdrawal of the drug with or without short-course systemic steroids can attain a cure. Rarely malignant transformation has been reported years later despite withdrawal of the offending drug, which necessitates a long-term follow up of the affected. We report an 80-year-old male patient who was receiving phenytoin sodium and who presented with diffuse erythema and infiltrated skin lesions which histologically resembled cutaneous B-cell lymphoma. Substituting phenytoin with levetiracetam achieved resolution of symptoms. Further evaluation was suggestive of a reactive process. A detailed drug history is of paramount importance in differentiating drug-induced pseudolymphoma from lymphoma. Searching literature we could not find any previous reports of phenytoin-induced cutaneous B-cell pseudolymphoma.
authors.affiliation: Department of Dermatology and Venereology, Govt Medical College, Kozhikode, Kerala, India.
authors.forename: Najeeba
authors.initials: N
authors.lastname: Riyaz
authors.affiliation: Department of Dermatology and Venereology, Govt Medical College, Kozhikode, Kerala, India.
authors.forename: Sarita
authors.initials: S
authors.lastname: Sasidharanpillai
authors.affiliation: Department of Pathology, Govt Medical College, Kozhikode, Kerala, India.
authors.forename: Karumathil P
authors.initials: KP
authors.lastname: Aravindan
authors.affiliation: Department of Pathology, Govt Medical College, Kozhikode, Kerala, India.
authors.forename: Babu K
authors.initials: BK
authors.lastname: Nobin
authors.affiliation: Department of Pathology, Govt Medical College, Kozhikode, Kerala, India.
authors.forename: Nisha T
authors.initials: NT
authors.lastname: Raghavan
authors.affiliation: Department of Dermatology and Venereology, Govt Medical College, Kozhikode, Kerala, India.
authors.forename: Pappinissery K
authors.initials: PK
authors.lastname: Nikhila
keywords: Cutaneous B-cell pseudolymphoma; histology; phenytoin