title: Pituitary metastasis: is there still a place for neurosurgical treatment?
abstract: Pituitary metastases are uncommon, ranging from 1 to 5 % of all metastases. Between 10 and 30 % of pituitary lesions are symptomatic responsible for diabetes insipidus, visual field defect or cranial nerve palsy. Primary sites are lung or breast in two-thirds of cases. There is no current reference concerning treatment of such lesions. Overall survival is poor and depends on primary site. Although the role of surgery is currently limited, discussion is warranted in several indications for diagnostic or symptomatic purposes. We report two cases of symptomatic pituitary metastases in a context of breast cancer and review the litterature concerning the role of surgery and other treatment modalities.
authors.affiliation: Department of Neurosurgery, Rouen University Hospital, 1, rue de Germont, 76031, Rouen Cedex, France. vianneygilard@hotmail.fr.
authors.forename: V
authors.identifier: http://orcid.org/0000-0001-6040-665X
authors.initials: V
authors.lastname: Gilard
authors.affiliation: Department of Oncology, Henri Becquerel Cancer Center, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Alexandru
authors.affiliation: Department of Neurosurgery, Strasbourg University Hospital, Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: Proust
authors.affiliation: Department of Neurosurgery, Rouen University Hospital, 1, rue de Germont, 76031, Rouen Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Derrey
authors.affiliation: Department of Neurosurgery, Rouen University Hospital, 1, rue de Germont, 76031, Rouen Cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Hannequin
authors.affiliation: Department of Neurosurgery, Rouen University Hospital, 1, rue de Germont, 76031, Rouen Cedex, France.
authors.forename: O
authors.initials: O
authors.lastname: Langlois
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D016896:Treatment Outcome
keywords: Pituitary gland- metastases; Surgical treatment