title: Association between the interleukin-6-174 G/C polymorphism and risk of ischemic stroke: a meta-analysis.
abstract: Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase databases were retrieved. Pooled ORs with 95%CIs were calculated using fixed- or random-effect models. A total of seven case-control studies containing 2025 patients and 2174 controls were enrolled into this meta-analysis. In combined analysis, the results showed no significant association between the IL6 -174 G/C polymorphism and ischemic stroke risk in the overall population (GG vs CC: OR = 1.22, 95%CI = 0.50-3.01; TT vs TC: OR = 0.97, 95%CI = 0.81-1.15; dominant: OR = 0.98, 95%CI = 0.70-1.38; or recessive: OR = 1.24, 95%CI = 0.57-2.70) models. In the subgroup analysis by race, no significant associations between the -174 G/C polymorphism in the IL6 gene and ischemic stroke risk were found in Caucasians or Asians. No publication bias was found in the present study (all P > 0.05). Overall, the meta-analysis results suggested that the IL6 -174 G/C polymorphism was not associated with an increased risk of ischemic stroke. Further large and well-designed studies are needed to confirm this conclusion.
authors.affiliation: Shandong University Hospital of Traditional Chinese Medicine, Jinan, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Jin
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
authors.forename: D L
authors.initials: DL
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
authors.forename: H
authors.initials: H
authors.lastname: Xiong
mesh_terms: D000483:Alleles; D002545:Brain Ischemia / Q000150:complications*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D020521:Stroke / Q000209:etiology*
chemical_list: D015850:Interleukin-6