title: Application of hypersensitivity skin testing in chemotherapy-induced pneumonitis.
abstract: Skin testing has been utilised to determine the culprit allergenic agent in drug reactions. Its application in the setting of hypersensitivity reaction relating to combination chemotherapeutic regimens may help identify the causative drug, allowing drug that is safe to be continued and avoiding limiting treatment options for patients. We report what we believe to be the first published case of hypersensitivity skin testing for gemcitabine-induced pneumonitis in a patient with metastatic leiomyosarcoma and another case of docetaxel-induced pneumonitis in a patient with metastatic HER2-positive breast cancer.
authors.affiliation: Department of Medical Oncology, The Canberra Hospital, Garran ACT 2605, Australia.
authors.forename: James C
authors.initials: JC
authors.lastname: Kuo
authors.affiliation: Department of Immunology, The Canberra Hospital, Garran ACT 2605, Australia. ; ANU Medical School, Australian National University, Canberra ACT 0200, Australia.
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Hawkins
authors.affiliation: Department of Medical Oncology, The Canberra Hospital, Garran ACT 2605, Australia. ; ANU Medical School, Australian National University, Canberra ACT 0200, Australia.
authors.forename: Desmond
authors.initials: D
authors.lastname: Yip
keywords: Antibodies, Monoclonal; Antineoplastic Agents; Hypersensitivity; Lung Diseases, Interstitial; Skin Tests