title: Inflammatory Myofibroblastic Tumor of the Left Sphenoid and Cavernous Sinus Successfully Treated with Partial Resection and High Dose Radiotherapy: Case Report and Review of the Literature.
abstract: Inflammatory myofibroblastic tumors, also known as plasma cell granulomas or inflammatory pseudotumors, are uncommon lesions that are known to arise in many areas of the body. They are uncommonly found in the skull base region where effective treatment can be difficult. Steroids and radiation therapy with gross total excision when possible remain the treatments of choice. However, the dosing of radiation remains controversial and many patients develop relapse despite medical management. We present the case of a patient who had an inflammatory myofibroblastic tumor of the sphenoid bone and cavernous sinus. He underwent partial surgical resection and transient steroid therapy. This was followed by high-dose fractionated radiotherapy. The patient demonstrated significant resolution in symptomatology and evidence of disease-free progression on repeat imaging.
authors.affiliation: Department of Neurosurgery, University of California, San Diego.
authors.forename: Brandon C
authors.initials: BC
authors.lastname: Gabel
authors.affiliation: Department of Pathology, University of California, San Diego.
authors.forename: Mary
authors.initials: M
authors.lastname: Goolsby
authors.affiliation: Department of Pathology, University of California, San Diego.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Hansen
authors.affiliation: Department of Neurosurgery, University of California, San Diego.
authors.forename: Hoi Sang
authors.initials: HS
authors.lastname: U
keywords: cavernous sinus; fractionated radiotherapy; mri; myofibroblastic tumor; plasma cell granuloma; steroids; tolosa-hunt syndrome