title: Ipsilateral cortical motor desynchronisation is reduced in Benign Epilepsy with Centro-Temporal Spikes.
abstract: OBJECTIVE
  Magnetoencephalography (MEG) and a simple motor paradigm were used to study induced sensorimotor responses and their relationship to motor skills in children diagnosed with Benign Epilepsy with Centro-Temporal Spikes (BECTS).
  
  
  METHODS
  Twenty-one children with BECTS and 15 age-matched controls completed a finger abduction task in MEG; movement-related oscillatory responses were derived and contrasted between groups. A subset of children also completed psycho-behavioural assessments. Regression analyses explored the relationship of MEG responses to manual dexterity performance, and dependence upon clinical characteristics.
  
  
  RESULTS
  In children with BECTS, manual dexterity was below the population mean (p=.002) and three showed severe impairment. Our main significant finding was of reduced ipsilateral movement related beta desynchrony (MRBDi) in BECTS relative to the control group (p=.03) and predicted by epileptic seizure recency (p=.02), but not age, medication status, or duration of epilepsy. Laterality scores across the entire cohort indicated that less lateralised MRBD predicted better manual dexterity (p=.04).
  
  
  CONCLUSIONS
  Altered movement-related oscillatory responses in ipsilateral motor cortex were associated with motor skill deficits in children with BECTS. These changes were more marked in those with more recent seizures.
  
  
  CONCLUSIONS
  These findings may reflect differences in inter-hemispheric interactions during motor control in BECTS.
authors.affiliation: Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK. Electronic address: lisabrindley78@gmail.com.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Brindley
authors.affiliation: Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK.
authors.forename: Loes
authors.initials: L
authors.lastname: Koelewijn
authors.affiliation: Dyscovery Centre, University of South Wales, Newport, UK.
authors.forename: Amanda
authors.initials: A
authors.lastname: Kirby
authors.affiliation: Dyscovery Centre, University of South Wales, Newport, UK.
authors.forename: Natalie
authors.initials: N
authors.lastname: Williams
authors.affiliation: Dyscovery Centre, University of South Wales, Newport, UK.
authors.forename: Marie
authors.initials: M
authors.lastname: Thomas
authors.affiliation: Department of Child Health, University Hospital of Wales, Cardiff, UK.
authors.forename: Johann
authors.initials: J
authors.lastname: Te Water-Naudé
authors.affiliation: Department of Child Health, University Hospital of Wales, Cardiff, UK.
authors.forename: Frances
authors.initials: F
authors.lastname: Gibbon
authors.affiliation: Schools of Pharmacy and Psychology, University of Auckland, Auckland, New Zealand.
authors.forename: Suresh
authors.initials: S
authors.lastname: Muthukumaraswamy
authors.affiliation: Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK.
authors.forename: Krish D
authors.initials: KD
authors.lastname: Singh
authors.affiliation: Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK; Welsh Epilepsy Centre, University Hospital of Wales, Cardiff, UK.
authors.forename: Khalid
authors.initials: K
authors.lastname: Hamandi
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D058256:Brain Waves / Q000502:physiology*; D002648:Child; D015331:Cohort Studies; D003344:Cortical Synchronization / Q000502:physiology*; D019305:Epilepsy, Rolandic / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology*
keywords: BECTS; Development; MEG; Movement; Oscillations