title: Chemoselection combined with alternating chemoradiotherapy or surgery for hypopharyngeal cancer.
abstract: In order to make possible organ preservation, since 2007 our hospital has performed induction chemotherapy (ICT) with cisplatin and 5-fluorouracil (PF) for hypopharyngeal cancer as chemoselection, followed by alternating chemoradiotherapy (ACRT) with docetaxel, cisplatin, and 5-fluorouracil in (TPF) good responders and curative surgery was used in poor responders.
  
  
  
  Twenty-six patients with stage III to stage IVB hypopharyngeal cancer received ICT. Eleven of the patients were classified as poor responders and received curative surgery. The remaining 15 patients were classified as good responders. Three of these patients underwent curative surgery, and the remaining 12 underwent ACRT.
  
  
  
  The primary lesions in the 12 ACRT patients responded completely to treatment without severe late toxicities. The estimated 3-year laryngectomy-free rate for all 26 patients was 23%. The estimated 3-year overall survival rates for all 26 patients, 12 patients treated with ACRT, and 14 patients who underwent curative surgery, were 79%, 75%, and 84%, respectively.
  
  
  
  The patients who underwent ACRT showed no significant difference in overall survival compared with the patients who underwent curative surgery. All the patients were able to proceed with this series of therapy, indicating that ICT with PF could be a feasible tool for choosing good responders. Because ACRT with TPF had a high response rate and fewer severe toxicities, this treatment could be safe and have enough impact to control hypopharyngeal cancer in good responders.
  
  
  
  4. Laryngoscope, 126:1349-1353, 2016.
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuzuka
authors.affiliation: Department of Radiation Oncology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sato
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Suzuki
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Saijoh
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ikeda
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Nakaegawa
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Tani
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Imaizumi
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Takamichi
authors.initials: T
authors.lastname: Matsui
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nomoto
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Nomoto
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tada
authors.affiliation: Department of Radiation Oncology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Omori
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D024221:Antineoplastic Protocols; D059248:Chemoradiotherapy / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D000077143:Docetaxel; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D060828:Induction Chemotherapy / Q000379:methods / Q000401:mortality*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010611:Pharyngectomy / Q000379:methods / Q000401:mortality*; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil
keywords: Hypopharyngeal cancer; alternating chemoradiotherapy; induction chemotherapy; larynx preservation; surgery