title: Cardiac computed tomography assessment of the near term impact of percutaneous ventricular restoration therapy (parachute(®) ) on mitral valve geometry.
abstract: OBJECTIVE
  The aim of current study is to assess the near term impact of percutaneous ventricular restoration therapy (PVR), Parachute(®) on mitral valve (MV) geometry by cardiac computed tomography (CCT).
  
  
  BACKGROUND
  Recent data demonstrates the feasibility of PVR for treatment of post anterior myocardial infarction (MI) heart failure. Little is known, however, about the interaction of the device and left ventricular structures, particularly the MV apparatus.
  
  
  METHODS
  This is a retrospective Core Laboratory analysis of Parachute Trials' CCT data. Patients with paired (before and after Parachute implant) CCT acquisitions were included into analysis. MV geometric parameters were measured.
  
  
  RESULTS
  Thirty-three patients were included in the analysis. The mean time of follow-up CCT post procedure was 188 ± 52 days. There were significant reduction in tenting height (A1P1: -1.70 ± 1.89 mm, -17.40 ± 20.20%; A2P2: -1.43 ± 1.89 mm, -12.10 ± 15.00%; A3P3: -1.54 ± 1.58 mm, -15.50 ± 15.20%, P < 0.001), tenting volume (-0.93 ± 0.60 mm3, -22.00 ± 11.40%, P < 0.001), systolic interpapillary muscle distance (-2.22 ± 2.11 mm, -7.51 ± 7.23%, P < 0.001) and diastolic interpapillary muscle distance (-3.14 ± 2.20 mm, -8.46 ± 5.73%, P < 0.001) post PVR.
  
  
  CONCLUSIONS
  In post anterior MI heart failure patients, PVR has favorable near term impact on MV geometry as assessed by CCT. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Harrington Heart and Vascular Institute, University Hospitals, Case Medical Center, Cleveland, Ohio.
authors.forename: Chor Cheung
authors.initials: CC
authors.lastname: Tam
authors.affiliation: Harrington Heart and Vascular Institute, University Hospitals, Case Medical Center, Cleveland, Ohio.
authors.forename: Anas
authors.initials: A
authors.lastname: Fares
authors.affiliation: Harrington Heart and Vascular Institute, University Hospitals, Case Medical Center, Cleveland, Ohio.
authors.forename: Amer
authors.initials: A
authors.lastname: Alaiti
authors.affiliation: Harrington Heart and Vascular Institute, University Hospitals, Case Medical Center, Cleveland, Ohio.
authors.forename: Kashif
authors.initials: K
authors.lastname: Shaikh
authors.affiliation: Department of Cardiology, Vivantes Klinikum Im Friedrichshain Und Am Urban, Berlin, Germany.|Rostock University Medical Center, Rostock, Germany.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ince
authors.affiliation: Institute of Cardiology, University of Latvia, Pauls Stradins Clinical University Hospita, Riga, Latvia.
authors.forename: Andrejs
authors.initials: A
authors.lastname: Erglis
authors.affiliation: Harrington Heart and Vascular Institute, University Hospitals, Case Medical Center, Cleveland, Ohio.
authors.forename: Hiram G
authors.initials: HG
authors.lastname: Bezerra
authors.affiliation: Division of Cardiovascular Medicine, the Ohio State University, Columbus, Ohio.
authors.forename: William T
authors.initials: WT
authors.lastname: Abraham
authors.affiliation: Harrington Heart and Vascular Institute, University Hospitals, Case Medical Center, Cleveland, Ohio.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Costa
authors.affiliation: Harrington Heart and Vascular Institute, University Hospitals, Case Medical Center, Cleveland, Ohio.
authors.forename: Guilherme F
authors.initials: GF
authors.lastname: Attizzani
mesh_terms: D000368:Aged; D056988:Anterior Wall Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D002986:Clinical Trials as Topic; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology; D061330:Multidetector Computed Tomography; D011237:Predictive Value of Tests; D020127:Recovery of Function; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
keywords: computer tomography; mitral valve; percutaneous ventricular restoration