title: Alcohol consumption and the risk of Barrett's esophagus: a comprehensive meta-analysis.
abstract: Several studies have been proposed to investigate the association between alcohol consumption and risk of Barrett's esophagus (BE), but as of yet, no quantitative summary of the literature to clarify the relationship between them. In our study, twenty eligible cohort studies involving 42925 participants were identified. Combined relative risk (RR) ratios for the highest versus lowest alcohol consumption levels were calculated. The alcohol dose-response analysis was performed to investigate the association between the increment consumption of 10 g/d alcohol and the risk of developing BE. Subgroup analyses were used to examine heterogeneity across the studies. A combined RR of 0.98 (0.62-1.34) was found when comparing highest vs. lowest alcohol consumption levels for BE. An inverse association between alcohol and incidence of BE (RR 0.51; 95% CI: 0.055-0.96) was demonstrated in women. Moreover, Asian drinkers had a relative higher risk of BE (RR 1.34; 95% CI: 1.11-1.56) compared with Western drinkers. In conclusion, our results showed that overall alcohol consumption was not associated with increased BE incidence. The limited data available on alcohol consumption supports a tentative inversion of alcohol consumption with BE risk in women, while Asian drinkers tend to have a higher risk of BE.
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease. 145 Middle Shandong Rd, Shanghai, 200001, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease. 145 Middle Shandong Rd, Shanghai, 200001, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease. 145 Middle Shandong Rd, Shanghai, 200001, China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease. 145 Middle Shandong Rd, Shanghai, 200001, China.
authors.forename: Zhao-Lian
authors.initials: ZL
authors.lastname: Bian
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease. 145 Middle Shandong Rd, Shanghai, 200001, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease. 145 Middle Shandong Rd, Shanghai, 200001, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hong
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease. 145 Middle Shandong Rd, Shanghai, 200001, China.
authors.forename: Hao-Yan
authors.initials: HY
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease. 145 Middle Shandong Rd, Shanghai, 200001, China.
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Fang
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D001471:Barrett Esophagus / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors