title: [Radiation injury of interstitial implantation 125I seeds on normal trachea tissue of rabbits].
abstract: OBJECTIVE
  To study the radition injury of tracheal mucous membrane tissue after interstitial implanted radioactive 125I in normal rabbit,improve the safety of clinical application.
  
  
  METHODS
  Sixty New Zealand rabbits, weighing 2.15-2.30 kg, were randomly divided into 1 w, 1 m, 2 m, 4 m and the control group, the control group was further divided into four subgroups. The 0.8mCi 125I seeds were implanted into the tissue by the first tracheal ring in the treatment groups and nonradioactive seeds were implanted in the control group. Taking the tracheal mucous membrane tissue for pathological examination by HE staining to observe the mucosal injury and VEGF, Pan-Cadherin immunohistochemical staining to observe the expression in differernt time.
  
  
  RESULTS
  Immunohistochemical staining: VEGF and Pan-Cadherin have statistically significant differences in the expression on different time, the expression is dynamic.
  
  
  CONCLUSIONS
  The expression of VEGF and Pan-Cadherin reflect the radioactive 125I seed has little influence on normal trachea tissue and the damage can be repaired by the regeneration of the basal cell.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.forename: Hongxin
authors.initials: H
authors.lastname: Chen
authors.forename: Haiying
authors.initials: H
authors.lastname: Jia
authors.forename: Dongxiu
authors.initials: D
authors.lastname: Rong
authors.forename: Xiuxian
authors.initials: X
authors.lastname: Lin
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000009:adverse effects; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D011817:Rabbits; D011832:Radiation Injuries / Q000473:pathology*; D014132:Trachea / Q000473:pathology* / Q000528:radiation effects*
chemical_list: D007457:Iodine Radioisotopes