title: Cough in interstitial lung disease.
abstract: Cough in the context of interstitial lung disease (ILD) has not been the focus of many studies. However, chronic cough has a major impact on quality of life in a significant proportion of patients with ILD. For the purpose of this review, we have chosen to highlight some of the more frequently encountered diffuse lung diseases including idiopathic pulmonary fibrosis, sarcoidosis, hypersensitivity pneumonitis and systemic sclerosis associated ILD. Many of the underlying mechanisms remain speculative and further research is now required to elucidate the complex pathways involved in the pathogenesis of chronic cough in ILD. This will hopefully pave the way for the identification of new therapeutic agents to alleviate this distressing and often intractable symptom.
authors.affiliation: Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Trust, United Kingdom. Electronic address: Justingrnr@googlemail.com.
authors.forename: Justin
authors.initials: J
authors.lastname: Garner
authors.affiliation: Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Trust, United Kingdom; National Heart and Lung Institute, Imperial College London, United Kingdom.
authors.forename: Peter M
authors.initials: PM
authors.lastname: George
authors.affiliation: Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Trust, United Kingdom; National Heart and Lung Institute, Imperial College London, United Kingdom.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Renzoni
mesh_terms: D000818:Animals; D003371:Cough / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D012018:Reflex
keywords: Cough; Interstitial lung disease; Lung fibrosis; Mechanisms