title: The Association in Elderly Hospitalized Patients, Between Psychotropic Drugs and Hip Fractures Resulting from Falls.
abstract: OBJECTIVE
  Psychotropic drug treatment has been associated with increased risk for falls and hip fractures in elderly patients. The authors examined the association between drug treatment and hip fractures resulting from falls in elderly hospitalized patients, focusing on the medications' anticholinergic properties.
  
  
  METHODS
  This retrospective case-control study was conducted in an acute geriatric ward in a general medical center. Medical records, including demographic, clinical, biochemical, and pharmacological variables, of elderly patients with hip fractures from falls (N = 185), admitted during a 2-year period, were reviewed and compared with a control group (N = 187) of patients matched for age and gender and without hip fractures.
  
  
  RESULTS
  The usage rates of antipsychotics, antidepressants, mood stabilizers, and various nonpsychiatric medications were similar in the two groups, except for hypnotics-anxiolytics (higher rates in hip-fracture patients). The Cumulative Illness Rating Scale for Geriatrics (CIRS-G) and diastolic blood pressure constituted very modest predictors of falls (R(2) = .038, p = .004). There were no significant differences in the anticholinergic burden values, clinical dementia ratings, and comorbidity burden between the two groups.
  
  
  CONCLUSIONS
  The rate of psychotropic drug use in general and their anticholinergic burden are similar in acutely admitted elderly patients with or without hip fractures. However, higher usage rate of anxiolytics found in the patients with hip fractures may indicate that this is a risk factor for hip fractures related to falls in elderly patients living in the community.
authors.affiliation: a Psychogeriatric Department , Geha Mental Health Center , Petah Tikva , Israel.|b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: Dov
authors.initials: D
authors.lastname: Aizenberg
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|c Research Unit , Geha Mental Health Center , Petah Tikva , Israel.|d The Felsenstein Medical Research Center, Rabin Medical Center , Petah Tikva , Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|e Department of Geriatrics , Beilinson Hospital, Rabin Medical Center , Petah Tikva , Israel.
authors.forename: Avraham
authors.initials: A
authors.lastname: Weiss
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|e Department of Geriatrics , Beilinson Hospital, Rabin Medical Center , Petah Tikva , Israel.
authors.forename: Maria
authors.initials: M
authors.lastname: Akopian
authors.affiliation: a Psychogeriatric Department , Geha Mental Health Center , Petah Tikva , Israel.|b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Amitai
authors.affiliation: b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.|e Department of Geriatrics , Beilinson Hospital, Rabin Medical Center , Petah Tikva , Israel.
authors.forename: Yichayaou
authors.initials: Y
authors.lastname: Beloosesky
mesh_terms: D000058:Accidental Falls / Q000706:statistics & numerical data*; D000369:Aged, 80 and over; D000375:Aging; D016022:Case-Control Studies; D015984:Causality; D005260:Female; D006620:Hip Fractures / Q000453:epidemiology*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007297:Inpatients / Q000523:psychology* / Q000706:statistics & numerical data; D007557:Israel / Q000453:epidemiology; D008297:Male; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D011619:Psychotropic Drugs