title: Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment.
abstract: Computational exposure science represents a frontier of environmental science that is emerging and quickly evolving.
  
  
  
  In this commentary, we define this burgeoning discipline, describe a framework for implementation, and review some key ongoing research elements that are advancing the science with respect to exposure to chemicals in consumer products.
  
  
  
  The fundamental elements of computational exposure science include the development of reliable, computationally efficient predictive exposure models; the identification, acquisition, and application of data to support and evaluate these models; and generation of improved methods for extrapolating across chemicals. We describe our efforts in each of these areas and provide examples that demonstrate both progress and potential.
  
  
  
  Computational exposure science, linked with comparable efforts in toxicology, is ushering in a new era of risk assessment that greatly expands our ability to evaluate chemical safety and sustainability and to protect public health.
  
  
  
  Egeghy PP, Sheldon LS, Isaacs KK, Özkaynak H, Goldsmith M-R, Wambaugh JF, Judson RS, Buckley TJ. 2016. Computational exposure science: an emerging discipline to support 21st-century risk assessment. Environ Health Perspect 124:697-702; http://dx.doi.org/10.1289/ehp.1509748.
authors.affiliation: Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Egeghy
authors.forename: Linda S
authors.initials: LS
authors.lastname: Sheldon
authors.forename: Kristin K
authors.initials: KK
authors.lastname: Isaacs
authors.forename: Halûk
authors.initials: H
authors.lastname: Özkaynak
authors.forename: Michael-Rock
authors.initials: MR
authors.lastname: Goldsmith
authors.forename: John F
authors.initials: JF
authors.lastname: Wambaugh
authors.forename: Richard S
authors.initials: RS
authors.lastname: Judson
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Buckley
mesh_terms: D019295:Computational Biology; D003198:Computer Simulation; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D004785:Environmental Pollutants; D004787:Environmental Pollution / Q000706:statistics & numerical data; D006801:Humans; D018570:Risk Assessment / Q000379:methods; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D004785:Environmental Pollutants