title: Liver disease in pregnancy.
abstract: Deranged liver function tests are encountered in 3% of pregnancies. The potential causes are classified as those unique to and those just incidental to pregnancy. Pregnancy-related diseases are the most frequent causes of liver dysfunction during pregnancy and exhibit a trimester-specific occurrence during pregnancy. Differentiation of liver dysfunction as that related to and just incidental to pregnancy is the key to management, especially when liver dysfunction is encountered after 28 weeks of pregnancy. It can be judged from the fact that delivery remains the cornerstone of management of pregnancy-related diseases except hyperemesis gravidarum. This is an overview of the causes of liver dysfunction during pregnancy; an update on the underlying mechanisms of their occurrence, especially liver diseases unique to pregnancy; and a methodological approach to their diagnosis and management.
authors.affiliation: Department of Obstetrics & Gynecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India. Electronic address: longshanks28@gmail.com.
authors.forename: Shashank
authors.initials: S
authors.lastname: Shekhar
authors.affiliation: Department of Gastroenterology, Max Superspeciality Hospital, Mohali, Punjab, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Diddi
mesh_terms: D019468:Disease Management; D005260:Female; D014943:Global Health; D006801:Humans; D015994:Incidence; D008107:Liver Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D008111:Liver Function Tests; D011247:Pregnancy; D011248:Pregnancy Complications; D011379:Prognosis
keywords: HELLP; Liver diseases; cholestasis pregnancy; pregnancy