title: Empty follicle syndrome: Successful pregnancy following dual trigger.
abstract: Empty follicle syndrome (EFS) is an uncommon, but the frustrating complication of assisted reproductive technology with failure to obtain oocytes after an adequate ovarian response to stimulation. Most of the reported cases of EFS are drug-related problems which are actually avoidable and do not represent any potential pathology and that the risk of genuine EFS (GEFS) is much smaller than was once thought. Our case is the first report of a pregnancy obtained after management of GEFS with dual trigger in a gonadotropin-releasing hormone (GnRH) antagonist cycle. In this report, we present a patient who underwent two oocyte retrievals, in which no oocytes were obtained. In the third in-vitro fertilization cycle, a dual trigger with the combination of GnRH agonist and human chorionic gonadotropin yielded 11 oocytes, which led to the transfer of 2 blastocysts resulting in a live birth. Changing the treatment protocol with dual trigger brought about a successful outcome.
authors.affiliation: Department of Reproductive Medicine, Milann - The Fertility Center, Bengaluru, Karnataka, India.
authors.forename: K
authors.initials: K
authors.lastname: Deepika
authors.affiliation: Department of Reproductive Medicine, Milann - The Fertility Center, Bengaluru, Karnataka, India.
authors.forename: Suvarna
authors.initials: S
authors.lastname: Rathore
authors.affiliation: Department of Reproductive Medicine, Milann - The Fertility Center, Bengaluru, Karnataka, India.
authors.forename: Nupur
authors.initials: N
authors.lastname: Garg
authors.affiliation: Department of Reproductive Medicine, Milann - The Fertility Center, Bengaluru, Karnataka, India.
authors.forename: Kamini
authors.initials: K
authors.lastname: Rao
keywords: Dual trigger; empty follicle syndrome; genuine empty follicle syndrome; gonadotropin-releasing hormone antagonist