title: Oral transmucosal administration of dexmedetomidine for sedation in 4 dogs.
abstract: Injectable dexmedetomidine (DM) is widely used for sedation, restraint, anxiolysis, and analgesia in veterinary medicine. Oral transmucosal dexmedetomidine (OTM DM) has been evaluated in horses, cats, and humans, but not in dogs. In this case series, OTM DM (mean dose of 32.6 μg/kg body weight) was given in the buccal pouch to 4 aggressive dogs in a hospital setting. Two of the dogs were subsequently euthanized, and in the other 2, sedation was reversed with atipamezole. Satisfactory sedation was achieved in all cases.
authors.affiliation: Animal Hospital Emergency Department (Cohen), Animal Hospital Behavior Department (Bennett), VCA Berwyn Animal Hospital, 2845 S. Harlem Ave, Berwyn, Illinois 60402, USA.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Cohen
authors.affiliation: Animal Hospital Emergency Department (Cohen), Animal Hospital Behavior Department (Bennett), VCA Berwyn Animal Hospital, 2845 S. Harlem Ave, Berwyn, Illinois 60402, USA.
authors.forename: Sara L
authors.initials: SL
authors.lastname: Bennett
mesh_terms: D058956:Administration, Mucosal; D000284:Administration, Oral; D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects; D000818:Animals; D016292:Procedural Sedation / Q000662:veterinary*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D008297:Male
chemical_list: D058669:Adrenergic alpha-2 Receptor Antagonists; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C050701:atipamezole; D020927:Dexmedetomidine