title: Intake of dietary antioxidants is inversely associated with biomarkers of oxidative stress among men with prostate cancer.
abstract: Prostate cancer is the most common non-cutaneous cancer and the second leading cause of cancer-related mortality among men in the USA. Growing evidence suggests that oxidative stress is involved in the development and progression of prostate cancer. In this study, the association between antioxidants from diet and supplements and biomarkers of oxidative stress in blood (n 278), urine (n 298) and prostate tissue (n 55) were determined among men from the North Carolina-Louisiana Prostate Cancer Project. The association between antioxidant intake and oxidative stress biomarkers in blood and urine was determined using linear regression, adjusting for age, race, prostate cancer aggressiveness and smoking status. Greater antioxidant intake was found to be associated with lower urinary 8-isoprostane concentrations, with a 10% increase in antioxidant intake corresponding to an unadjusted 1·1% decrease in urinary 8-isoprostane levels (95% CI -1·7, -0·3%; P value<0·01) and an adjusted 0·6% decrease (95% CI -1·4, 0·2%; P value=0·16). In benign prostate tissue, thioredoxin 1 was inversely associated with antioxidant intake (P=0·02). No significant associations were found for other blood or urinary biomarkers or for malignant prostate tissue. These results indicate that antioxidant intake may be associated with less oxidative stress among men diagnosed with prostate cancer.
authors.affiliation: 1Department of Nutritional Sciences,University of Connecticut,Storrs,CT 06269-4017,USA.
authors.forename: Terrence M
authors.initials: TM
authors.lastname: Vance
authors.affiliation: 2Roswell Park Cancer Institute,Buffalo,NY 14263,USA.
authors.forename: Gissou
authors.initials: G
authors.lastname: Azabdaftari
authors.affiliation: 2Roswell Park Cancer Institute,Buffalo,NY 14263,USA.
authors.forename: Elena A
authors.initials: EA
authors.lastname: Pop
authors.affiliation: 1Department of Nutritional Sciences,University of Connecticut,Storrs,CT 06269-4017,USA.
authors.forename: Sang Gil
authors.initials: SG
authors.lastname: Lee
authors.affiliation: 3Epidemiology and Genomics Research Program,Division of Cancer Control and Population Sciences,National Cancer Institute,Bethesda,MD 20892,USA.
authors.forename: L Joseph
authors.initials: LJ
authors.lastname: Su
authors.affiliation: 4School of Public Health,Louisiana State University Health Sciences Center,New Orleans,LA 70112,USA.
authors.forename: Elizabeth T H
authors.initials: ET
authors.lastname: Fontham
authors.affiliation: 5School of Public Health,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599,USA.
authors.forename: Jeannette T
authors.initials: JT
authors.lastname: Bensen
authors.affiliation: 6Department of Epidemiology and Biostatistics,Cancer Prevention and Control Program,University of South Carolina,Columbia,SC 29208,USA.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Steck
authors.affiliation: 7David Geffen School of Medicine,University of California,Los Angeles,CA 90095,USA.
authors.forename: Lenore
authors.initials: L
authors.lastname: Arab
authors.affiliation: 2Roswell Park Cancer Institute,Buffalo,NY 14263,USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Mohler
authors.affiliation: 8Department of Statistics,University of Connecticut,Storrs,CT 06269,USA.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Chen
authors.affiliation: 1Department of Nutritional Sciences,University of Connecticut,Storrs,CT 06269-4017,USA.
authors.forename: Sung I
authors.initials: SI
authors.lastname: Koo
authors.affiliation: 1Department of Nutritional Sciences,University of Connecticut,Storrs,CT 06269-4017,USA.
authors.forename: Ock K
authors.initials: OK
authors.lastname: Chun
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D004032:Diet; D019587:Dietary Supplements; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000652:urine; D005247:Feeding Behavior; D006801:Humans; D008145:Louisiana; D008297:Male; D008875:Middle Aged; D009657:North Carolina; D018384:Oxidative Stress / Q000187:drug effects*; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism*; D013879:Thioredoxins / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; C075750:8-epi-prostaglandin F2alpha; D013879:Thioredoxins; D015237:Dinoprost
keywords: Antioxidants; Diets; Oxidative stress; PCaP North Carolina-Louisiana Prostate Cancer Project; Prostate cancer; Trx1 thioredoxin 1