title: Kinetics of Highly Sensitive Troponin T after Cardiac Surgery.
abstract: Perioperative myocardial infarction (PMI) confers a considerable risk in cardiac surgery settings; finding the ideal biomarker seems to be an ideal goal. Our aim was to assess the diagnostic accuracy of highly sensitive troponin T (hsTnT) in cardiac surgery settings and to define a diagnostic level for PMI diagnosis. This was a single-center prospective observational study analyzing data from all patients who underwent cardiac surgeries. The primary outcome was the diagnosis of PMI through a specific level. The secondary outcome measures were the lengths of mechanical ventilation (LOV), stay in the intensive care unit (LOSICU), and hospitalization. Based on the third universal definition of PMI, patients were divided into two groups: no PMI (Group I) and PMI (Group II). Data from 413 patients were analyzed. Nine patients fulfilled the diagnostic criteria of PMI, while 41 patients were identified with a 5-fold increase in their CK-MB (≥ 120 U/L). Using ROC analysis, a hsTnT level of 3,466 ng/L or above showed 90% sensitivity and 90% specificity for the diagnosis of PMI. Secondary outcome measures in patients with PMI were significantly prolonged. In conclusion, the hsTnT levels detected here paralleled those of CK-MB and a cut-off level of 3466 ng/L could be diagnostic of PMI.
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar ; Department of Critical Care Medicine, Beni Suef University, Beni-Suef 62511, Egypt.
authors.forename: Amr S
authors.initials: AS
authors.lastname: Omar
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
authors.forename: Suraj
authors.initials: S
authors.lastname: Sudarsanan
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar ; Department of Anesthesia, Al-Azhar University, Cairo 11651, Egypt.
authors.forename: Samy
authors.initials: S
authors.lastname: Hanoura
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar ; Department of Anesthesia, Al-Azhar University, Cairo 11651, Egypt.
authors.forename: Hany
authors.initials: H
authors.lastname: Osman
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
authors.forename: Praveen C
authors.initials: PC
authors.lastname: Sivadasan
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Shouman
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
authors.forename: Alejandro Kohn
authors.initials: AK
authors.lastname: Tuli
authors.affiliation: Department of Medical Research, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
authors.forename: Rajvir
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
authors.forename: Abdulaziz
authors.initials: A
authors.lastname: Al Khulaifi
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D059035:Perioperative Period / Q000009:adverse effects; D011183:Postoperative Complications; D012372:ROC Curve; D013903:Thoracic Surgery; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T