title: Subclassification of Barcelona Clinic Liver Cancer B and C hepatocellular carcinoma: A cohort study of the multicenter registry database.
abstract: We aimed to subclassify hepatocellular carcinoma (HCC) using Barcelona Clinic Liver Cancer intermediate and advanced stages, which include a highly heterogeneous population.
  
  
  
  From two registries ("random" and "voluntary" cohorts in the Korean Liver Cancer Study Group), patients who were newly diagnosed as HCC with intermediate or advanced stage between 2003 and 2005 were considered eligible. Overall survival (OS) was analyzed using Kaplan-Meier method with comparison by log-rank test.
  
  
  
  Patients with intermediate-stage HCC (n = 994) were subclassified according to tumor size and Child-Pugh class. Patients with tumor size < 5 cm (B1), those with tumor size ≥ 5 cm and Child-Pugh A (B2), and those with tumor size ≥ 5 cm and Child-Pugh B (B3) had median OS of 30.73, 20.60, and 9.23 months, respectively (P < 0.001 by log-rank test). Among patients with advanced stage HCC (n = 1746), patients were subclassified according to presence of significant portal vein invasion (sPVI; defined as portal vein invasion in lobar, main, or contralateral branch) and extrahepatic spread (EHS). Patients with neither sPVI nor EHS (C1), those with either sPVI or EHS (C2), and those with both sPVI and EHS (C3) had median OS of 8.43, 4.63, and 3.63 months, respectively (P < 0.001 by log-rank test).
  
  
  
  Subclassification of Barcelona Clinic Liver Cancer intermediate and advanced stages might be useful for determining patient prognosis and guiding treatment strategies for HCC.
authors.affiliation: The Korean Liver Cancer Study Group, Yonsei University College of Medicine, Seoul, Korea.|Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon Metropolitan City, Korea.|Institute for Integrative Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon Metropolitan City, Korea.
authors.forename: Sangheun
authors.initials: S
authors.lastname: Lee
authors.affiliation: The Korean Liver Cancer Study Group, Yonsei University College of Medicine, Seoul, Korea.|Departments ofInternal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Beom Kyung
authors.initials: BK
authors.lastname: Kim
authors.affiliation: Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kijun
authors.initials: K
authors.lastname: Song
authors.affiliation: The Korean Liver Cancer Study Group, Yonsei University College of Medicine, Seoul, Korea.|Departments ofInternal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Park
authors.affiliation: The Korean Liver Cancer Study Group, Yonsei University College of Medicine, Seoul, Korea.|Departments ofInternal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Ahn
authors.affiliation: The Korean Liver Cancer Study Group, Yonsei University College of Medicine, Seoul, Korea.|Departments ofInternal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Seung Up
authors.initials: SU
authors.lastname: Kim
authors.affiliation: The Korean Liver Cancer Study Group, Yonsei University College of Medicine, Seoul, Korea.|Departments ofInternal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kwang-Hyub
authors.initials: KH
authors.lastname: Han
authors.affiliation: The Korean Liver Cancer Study Group, Yonsei University College of Medicine, Seoul, Korea.|Departments ofInternal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Do Young
authors.initials: DY
authors.lastname: Kim
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000145:classification* / Q000401:mortality / Q000473:pathology*; D015331:Cohort Studies; D019992:Databases as Topic; D005260:Female; D005544:Forecasting; D006801:Humans; D008113:Liver Neoplasms / Q000145:classification* / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009367:Neoplasm Staging; D011379:Prognosis; D012042:Registries; D015996:Survival Rate
keywords: Barcelona Clinic Liver Cancer stage; hepatocellular carcinoma; overall survival; prognosis; subclassification