title: Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh.
abstract: OBJECTIVE
  To determine the effect of prenatal maternal vitamin D supplementation on infant vitamin D status in a tropical region where vitamin D supplementation is not routine.
  
  
  METHODS
  A prospective observational follow-up of a randomized trial.
  
  
  METHODS
  Maternal-child health facility in Dhaka, Bangladesh (23°N).
  
  
  METHODS
  Infants born to pregnant women (n 160) randomized to receive 875 µg (35 000 IU) cholecalciferol (vitamin D3) per week (VD) or placebo (PL) during the third trimester were followed from birth until 6 months of age (n 115). Infant serum 25-hydroxyvitamin D concentration (25(OH)D) was measured at <1, 2, 4 and 6 months of age.
  
  
  RESULTS
  Mean infant 25(OH)D was higher in the VD v. PL group at <1 month of age (mean (sd): 80 (20) nmol/l v. 22 (18) nmol/l; P<0·001), but the difference was attenuated by 2 months (52 (19) nmol/l v. 40 (23) nmol/l; P=0·05). Groups were similar at 4 months (P=0·40) and 6 months (n 72; P=0·26). In the PL group, mean infant 25(OH)D increased to 78 (95 % CI 67, 88) nmol/l by 6 months of age (n 34). 25(OH)D was higher with infant formula-feeding and higher in summer v. winter.
  
  
  CONCLUSIONS
  Prenatal third-trimester vitamin D supplementation (875 µg (35 000 IU)/week) significantly ameliorated infant vitamin D status during the neonatal period when the risk of vitamin D deficiency is greatest. Further research is warranted to determine factors that contribute to the rise in 25(OH)D during the first 6 months of life among breast-fed infants in this setting.
authors.affiliation: 1Centre for Global Child Health,The Hospital for Sick Children,686 Bay Street,Toronto,ON,Canada,M5G 0A4.
authors.forename: Nandita
authors.initials: N
authors.lastname: Perumal
authors.affiliation: 3Centre for Child and Adolescent Health,International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b),Mohakhali,Dhaka,Bangladesh.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Al Mahmud
authors.affiliation: 3Centre for Child and Adolescent Health,International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b),Mohakhali,Dhaka,Bangladesh.
authors.forename: Abdullah H
authors.initials: AH
authors.lastname: Baqui
authors.affiliation: 1Centre for Global Child Health,The Hospital for Sick Children,686 Bay Street,Toronto,ON,Canada,M5G 0A4.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Roth
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D001459:Bangladesh; D019587:Dietary Supplements; D007227:Infant Nutritional Physiological Phenomena / Q000502:physiology; D009035:Mothers; D011263:Pregnancy Trimester, Third; D039401:Prenatal Nutritional Physiological Phenomena / Q000502:physiology; D011446:Prospective Studies; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic
chemical_list: D014807:Vitamin D
keywords: 25-Hydroxyvitamin D; Bangladesh; Cholecalciferol; Developing countries; Infant; Nutrition; Paediatrics; Pregnancy