title: The effect of kisspeptin on the functional characteristics of isolated NK cells.
abstract: The effect of kisspeptin at concentrations typical of pregnancy on the functional activity of isolated cytokine-primed NK cells has been investigated. The hormone has been shown to promote an increase in the proportion of CD56(bright) NK cells, as well as an increase in the L-selectin expression on the cell surface. Assessment of cytokine levels has shown that kisspeptin suppresses the production of IL-4, IL-10, and IFN-γ while stimulating the production of TGF-β by isolated NK cells. The overall effect of the hormone investigated consisted in the formation of a phenotype and a cytokine spectrum characteristic of the regulatory NK3 subpopulation of NK cells in pregnancy.
authors.affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia. olia15_77@mail.ru.
authors.forename: S V
authors.initials: SV
authors.lastname: Shirshev
authors.affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Nekrasova
authors.affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia.
authors.forename: O L
authors.initials: OL
authors.lastname: Gorbunova
authors.affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Orlova
authors.affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia.
authors.forename: I L
authors.initials: IL
authors.lastname: Maslennikova
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics / Q000378:metabolism; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism; D015847:Interleukin-4 / Q000235:genetics / Q000378:metabolism; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000378:metabolism; D059648:Kisspeptins / Q000494:pharmacology*; D019041:L-Selectin / Q000235:genetics / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism
chemical_list: D059648:Kisspeptins; D016212:Transforming Growth Factor beta; D019041:L-Selectin; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma