title: Are there any new insights for G-CSF and/or AMD3100 in chemotherapy of haematological malignants?
abstract: AML is a common life-threatening blood system malignancy. The treatment of AML continues to face greater challenges. An abnormal haematopoietic niche with high adhesion and proliferation might be the root cause of resistance and relapse. Most leukaemia cells are stored in the endosteal niche and recess in the G0 phase, and they are not sensitive to varieties of radiotherapies and chemotherapies. G-CSF and AMD3100 are increasingly used in priming chemotherapy. G-CSF can promote leukaemia cells to the cell cycle, which improves the complete remission rate of leukaemia patients. AMD3100, the novel CXCR4 antagonist, could also potentially promote leukaemia cells to cell cycle and improve the susceptibility of leukaemia cells to chemotherapeutic agents. The combination of them enhances anti-leukaemia effect. So in this review, we explore the function of G-CSF and/or AMD3100 in the priming chemotherapy of haematological malignants.
authors.affiliation: Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing, 400037, People's Republic of China.
authors.forename: Zhao-Hua
authors.initials: ZH
authors.lastname: Shen
authors.affiliation: Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing, 400037, People's Republic of China.
authors.forename: Dong-Feng
authors.initials: DF
authors.lastname: Zeng
authors.affiliation: Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing, 400037, People's Republic of China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Ma
authors.affiliation: Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing, 400037, People's Republic of China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing, 400037, People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing, 400037, People's Republic of China. peiyankong@aliyun.com.
authors.forename: Pei-Yan
authors.initials: PY
authors.lastname: Kong
mesh_terms: D000970:Antineoplastic Agents; D001596:Benzylamines; D000080027:Cyclams; D016179:Granulocyte Colony-Stimulating Factor; D006412:Hematopoietic Stem Cells; D006571:Heterocyclic Compounds; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D055153:Stem Cell Niche
chemical_list: D000970:Antineoplastic Agents; D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor
keywords: AMD3100; Granulocyte colony-stimulating factor; Leukaemia; Priming; SDF-1/CXCR4