title: Glycocalyx Remodeling with Glycopolymer-Based Proteoglycan Mimetics.
abstract: The cellular glycocalyx controls many of the crucial signaling pathways involved in cellular development. Synthetic materials that can mimic the multivalency and three-dimensional architecture of native glycans serve as important tools for deciphering and exploiting the roles of these glycans. Here we describe a chemical approach for the engineering of growth-factor interactions at the surfaces of stem cells using synthetic glycomimetic materials, with an eye towards promoting their commitment towards specific cell lineages with therapeutic potential.
authors.affiliation: Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, 0358, La Jolla, CA, 92093-0358, USA.
authors.forename: Mia L
authors.initials: ML
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, 0358, La Jolla, CA, 92093-0358, USA.
authors.forename: Raymond A A
authors.initials: RA
authors.lastname: Smith
authors.affiliation: Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, 0358, La Jolla, CA, 92093-0358, USA.
authors.forename: Greg W
authors.initials: GW
authors.lastname: Trieger
authors.affiliation: Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, 0358, La Jolla, CA, 92093-0358, USA. kgodula@ucsd.edu.
authors.forename: Kamil
authors.initials: K
authors.lastname: Godula
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D019276:Glycocalyx / Q000737:chemistry*; D006001:Glycoconjugates / Q000737:chemistry*; D051379:Mice; D011108:Polymers / Q000737:chemistry*; D011509:Proteoglycans / Q000737:chemistry; D013234:Stem Cells / Q000737:chemistry*
chemical_list: D006001:Glycoconjugates; D011108:Polymers; D011509:Proteoglycans
keywords: Glycan microarrays; Glycopolymers; Glycosaminoglycans; Proteoglycans; Stem cell differentiation; Stem cell s