title: miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function.
abstract: It has become clear that tumor stroma components are engaged in an active and complex molecular cross-talk that has serious implications for immunological recognition of tumor cells in shaping the microenvironment. Hypoxia which is a major component of tumor microenvironment influences the characteristics of neoplasia by favoring heterogeneity, invasiveness, metastatic potency and tumor progression. In this regard, an important mode of communication between carcinoma cells and immune cells may involve tumor-derived microvesicles, which are able to carry lipids, proteins, mRNAs and miRNAs. This review covers new evidence indicating that the efficacy of the cell-mediated cytotoxicity (CTLs and NK) may be dependent on hypoxia induced miRNA and microvesicles in the tumor microenvironment by inhibiting the efficacy of natural host anti-tumor immune response and improving the ability of tumors to avoid immunosurveillance. This emphasizes that hypoxic tumors actively develop additional mechanisms to suppress the sensing of the immunologic danger signals in order to survive and propagate without inciting anti-tumor immunity.
authors.affiliation: INSERM U1186, Equipe Labellisée Par La Ligue Contre Le Cancer, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94805 Villejuif, France.
authors.forename: Muhammad Zaeem
authors.initials: MZ
authors.lastname: Noman
authors.affiliation: Laboratory of Experimental Cancer Research, Luxembourg Institute of Health, 84, Val Fleuri, L-1526 Luxembourg, Luxembourg.
authors.forename: Bassam
authors.initials: B
authors.lastname: Janji
authors.affiliation: Laboratory of Experimental Cancer Research, Luxembourg Institute of Health, 84, Val Fleuri, L-1526 Luxembourg, Luxembourg.
authors.forename: Guy
authors.initials: G
authors.lastname: Berchem
authors.affiliation: INSERM U1186, Equipe Labellisée Par La Ligue Contre Le Cancer, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94805 Villejuif, France. Electronic address: salem.chouaib@gustaveroussy.fr.
authors.forename: Salem
authors.initials: S
authors.lastname: Chouaib
mesh_terms: D000818:Animals; D002450:Cell Communication; D055252:Cell-Derived Microparticles / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism*; D019139:Tumor Escape; D000072258:Tumor Hypoxia; D059016:Tumor Microenvironment
chemical_list: C543800:MIRN210 microRNA, human; D035683:MicroRNAs
keywords: HIF; Hypoxia; Immunosuppression and antitumor-immune response; MVs; Tumor microenvironment; miR-210