title: [Expression level and significance of IL-17 and IL-23 in serum and nasal secretion of patients with allergic rhinitis and non-allergrie rhinitis].
abstract: OBJECTIVE
  To investigate the effect of IL-17 and IL-23 in the pathogenesis of allergic rhinitis(AR) and non. allergic rhinitis(NAR).
  
  
  METHODS
  Selected 156 cases of patients with allergic rhinitis (AR group) and 59 cases of patients with non-allergic rhinitis (NAR group), 60 cases of healthy people (control group). All cases in AR group and NAR groups were evaluated by a visual analog scale (VAS) score of nasal symptoms. Collected peripheral blood and nasal secretions in all cases and then detected IL-17 and IL-23 expression levels.
  
  
  RESULTS
  There was no significant difference in VAS score of AR group and NAR group (P>0. 05). IL-17 and IL-23 levels of serum and nasal secretions in AR group and NAR group were both higher than control group, with a highly significant difference (P <0. 05). The research showed a clear correlation between expression of IL-17 and IL-23 both in serum and nasal secretions of AR group and NAR(P<0. 05).
  
  
  CONCLUSIONS
  IL-17 and IL-23 may be important cytokines and IL-23/IL-17 pathway may play a significant role in the pathogenesis of allergic rhinitis and non-allergic rhinitis.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Guoxi
authors.initials: G
authors.lastname: Zheng
authors.forename: Luyao
authors.initials: L
authors.lastname: Zhang
authors.forename: Kang
authors.initials: K
authors.lastname: Zhu
authors.forename: Wenjun
authors.initials: W
authors.lastname: Xin
authors.forename: Junrong
authors.initials: J
authors.lastname: Wei
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D053759:Interleukin-23 / Q000097:blood / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism; D012220:Rhinitis / Q000097:blood / Q000378:metabolism*; D065631:Rhinitis, Allergic / Q000097:blood / Q000378:metabolism*
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17; D053759:Interleukin-23