title: Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke.
abstract: In this study to identify prognostic biomarkers for ischemic stroke (IS) outcome, we monitored monocyte number and monocyte chemoattractant protein (MCP-1) concentration in peripheral blood of 44 patients with IS during the week following IS. According to the severity of IS, patients were allocated to three groups: patients with transient ischemic attack (TIA), patients with National Institute of Health Stroke Scale (NIHSS) score ≤ 12, and patients with NIHSS > 12. In patients with NIHSS > 12 statistically significant increased number of monocytes was observed on day 7. MCP-1 plasma concentration initially increased, decreased at day 3 in patients with NIHSS > 12 and increased and restored on day 7. A negative correlation between the number of monocytes and MCP-1 concentration was observed on day 3 after IS. Higher day-7 MCP-1 level was associated with higher modified Rankin Scale (mRS) value (indicating worse outcome) at 90 days post-IS in patients with NIHSS > 12. Our findings suggest that number of monocytes and plasma MCP-1 level could be clinical prognostic biomarkers as early predictors of disease outcome in patients with IS.
authors.affiliation: Clinic of Neurology, Clinical Hospital Center Rijeka, Krešimirova 42, Rijeka, Croatia.
authors.forename: David
authors.initials: D
authors.lastname: Bonifačić
authors.affiliation: Students of integrated undergraduate and graduate university study of medicine, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, Rijeka, Croatia.
authors.forename: Adrian
authors.initials: A
authors.lastname: Toplak
authors.affiliation: Students of integrated undergraduate and graduate university study of medicine, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, Rijeka, Croatia.
authors.forename: Indira
authors.initials: I
authors.lastname: Benjak
authors.affiliation: Department of Anestesiology, Reanimatology and Intensive Care, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, 51000, Rijeka, Croatia. vlatkast@medri.uniri.hr.
authors.forename: Vlatka Sotošek
authors.initials: VS
authors.lastname: Tokmadžić
authors.affiliation: Department of Physics, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, Rijeka, Croatia.
authors.forename: Andrica
authors.initials: A
authors.lastname: Lekić
authors.affiliation: Department of Physiology and Immunology, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, Rijeka, Croatia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Kučić
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000706:statistics & numerical data; D008297:Male; D009000:Monocytes / Q000473:pathology*; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2
keywords: Cerebral ischemic stroke; Monocyte chemoattractant protein 1; National Institute of Health Stroke Scale score; Prognostic biomarkers; Proinflammatory cytokines