title: Altered functional interaction hub between affective network and cognitive control network in patients with major depressive disorder.
abstract: Emotional and cognitive dysregulation in major depressive disorder (MDD) have been consistently considered to be attributed to structural and functional abnormalities in affective network (AN) and cognitive control network (CCN). This study was to investigate the functional connectivity (FC) patterns and altered functional interactions between both networks in MDD. We investigated resting-state functional connectivity magnetic resonance imaging in the AN and the CCN in 25 MDD and 35 healthy controls (HC). The seeds were from voxel-based morphometry (VBM) analysis results. Then FC within the AN was assessed from a seed placed in the left amygdala (AMG) and FC within CCN was determined by placing seeds in the right dorsolateral prefrontal cortex (DLPFC). Compared with HC, MDD showed reduced FC between left AMG and bilateral precuneus and right anterior cingulated cortex (ACC) within AN and reduced FC between right DLPFC and left cuneus, left lingual gyrus, and right ACC within CCN. An interaction hub of altered FC in MDD between AN and CCN located in the right ACC. Interestingly, the altered FC between right ACC and left AMG was negatively correlated with depressive symptom score while the altered FC between right ACC and DLPFC was positively correlated the executive function in MDD. The right ACC not only supports the cognitive and emotional processes, but also is an altered functional interaction hub between AN and CCN in MDD. It further suggest multiple sources of dysregulation in AN and CCN implicate both top-down cognitive control and bottom-up emotional expression dysfunction in MDD.
authors.affiliation: The Third Psychiatric Department, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan Province, PR China.
authors.forename: Ya-li
authors.initials: YL
authors.lastname: Wang
authors.affiliation: The Seventh Psychiatric Department, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan Province, PR China.
authors.forename: Shu-zhen
authors.initials: SZ
authors.lastname: Yang
authors.affiliation: The Medical Department, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan Province, PR China.
authors.forename: Wei-li
authors.initials: WL
authors.lastname: Sun
authors.affiliation: The Third Psychiatric Department, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan Province, PR China. Electronic address: 13183105551@163.com.
authors.forename: Yu-zhong
authors.initials: YZ
authors.lastname: Shi
authors.affiliation: Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China. Electronic address: lixiang1110@163.com.
authors.forename: Hui-feng
authors.initials: HF
authors.lastname: Duan
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D003865:Major Depressive Disorder / Q000503:physiopathology*; D004644:Emotions / Q000502:physiology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D012146:Rest
keywords: ACC; AMG; AN; Affective network; Amygdala; Anterior cingulated cortex; CCN; Cognitive control network; DLPFC; Dorsolateral prefrontal cortex; FC; Functional connectivity; HAMD; Hamilton Depression Scale; MDD; Major depressive disorder; affective network; amygdale; anterior cingulated cortex; cognitive control network; dorsolateral prefrontal cortex; functional connectivity; major depressive disorder