title: Biologics in inflammatory bowel disease: what are the data?
abstract: BACKGROUND
  Over the last decade, biologics have gained an important place for the treatment of moderate to severe inflammatory bowel disease (IBD), and many randomized control trials have evaluated their efficacy.
  
  
  OBJECTIVE
  The goal of this review is to analyze the results of these trials and to highlight the evidence and indications emerging from these studies for their implementation in the management of IBD patients.
  
  
  METHODS
  A PubMed search was realized to screen high-quality clinical trials studying biologic agents currently available in clinics for the treatment of IBD. Words used were: "infliximab," "adalimumab," "certolizumab," "golimumab," "natalizumab," "vedolizumab," "ustekinumab," "azathioprine," "methotrexate," "Crohn's disease," and "ulcerative colitis."
  
  
  RESULTS
  In Crohn's disease, studies supporting induction and maintenance therapies were documented for infliximab, adalimumab, certolizumab, natalizumab, vedolizumab, and ustekinumab. Infliximab, adalimumab, and certolizumab have evidences for fistulizing Crohn's disease and only infliximab and adalimumab have evidences for mucosal healing. In ulcerative colitis, studies supporting induction, maintenance, and mucosal healing were found with infliximab, adalimumab, golimumab, and vedolizumab. Only infliximab was associated with evidences for combination therapy with thiopurine and acute severe colitis in ulcerative colitis.
  
  
  CONCLUSIONS
  Management with biologics in IBD patients is well validated by high-quality clinical trials.
authors.affiliation: Department of Gastroenterology, CHUM, Université de Montréal, Montreal, Canada ; The Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Côté-Daigneault
authors.affiliation: Department of Gastroenterology, CHUM, Université de Montréal, Montreal, Canada.
authors.forename: Mickael
authors.initials: M
authors.lastname: Bouin
authors.affiliation: Department of Gastroenterology, CHUM, Université de Montréal, Montreal, Canada.
authors.forename: Raymond
authors.initials: R
authors.lastname: Lahaie
authors.affiliation: The Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: Jean-Frédéric
authors.initials: JF
authors.lastname: Colombel
authors.affiliation: Department of Gastroenterology, CHUM, Université de Montréal, Montreal, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Poitras
keywords: Crohn's disease; Inflammatory bowel disease; biologics; clinical trials; ulcerative colitis