title: Liraglutide and DPP-4 inhibitors - side effects comparative clinical study.
abstract: The objective of this study was to monitor the side effects of the GLP-1 receptor agonist liraglutide in comparison to those of DPP-4 inhibitors (sitagliptin and vildagliptin), in order to determine their safety, tolerability and therapeutic efficiency. The study was carried out in the "Heart and Diabetes Center NRW" and included overweight patients with type 2 diabetes whose therapeutic regimen was switched to liraglutide or DPP-4 inhibitors. A validated questionnaire method was used to monitor the side effects during the hospitalization period, then again at 3, and 6 months after the beginning of the therapy. The therapy with liraglutide was associated with more side effects than the one with DPP-4 inhibitors. In general, side effects were declining with time, thus only few patients stopped therapy. The incretin therapy turned out to be a safe and effective therapeutic option for patients with type 2 diabetes mellitus.
authors.affiliation: Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, Germany ; Faculty of Pharmacy, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Luminiţa
authors.initials: L
authors.lastname: Timofte
authors.affiliation: Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Stratmann
authors.affiliation: Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, Germany.
authors.forename: Wulf
authors.initials: W
authors.lastname: Quester
authors.affiliation: Faculty of Pharmacy, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Marius Traian
authors.initials: MT
authors.lastname: Bojiţă
authors.affiliation: Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, Germany.
authors.forename: Diethelm
authors.initials: D
authors.lastname: Tschoepe
keywords: DPP-4 inhibitors; liraglutide; side effects