title: Exposure-response modeling of non-cancer effects in humans exposed to Libby Amphibole Asbestos; update.
abstract: The United States Environmental Protection Agency (EPA) developed a quantitative exposure-response model for the non-cancer effects of Libby Amphibole Asbestos (LAA) (EPA, 2014). The model is based on the prevalence of localized pleural thickening (LPT) in workers exposed to LAA at a workplace in Marysville, Ohio (Lockey et al., 1984; Rohs et al., 2008). Recently, Lockey et al. (2015a) published a follow-up study of surviving Marysville workers. The data from this study increases the number of cases of LPT and extends the observation period for a number of workers, thereby providing a strengthened data set to define and constrain the optimal exposure-response model for non-cancer effects from inhalation exposure to LAA. The new data were combined with the previous data to update the exposure-response modeling for LPT. The results indicate that a bivariate model using cumulative exposure and time since first exposure is appropriate, and the benchmark concentration is similar to the findings previously reported by EPA (2014). In addition, the data were also used to develop initial exposure-response models for diffuse pleural thickening (DPT) and small interstitial opacities (SIO).
authors.affiliation: Environmental Protection Agency, 1595 Wynkoop St, Denver, CO, 80202, United States. Electronic address: Benson.Bob@epa.gov.
authors.forename: Robert
authors.initials: R
authors.lastname: Benson
authors.affiliation: Environmental Protection Agency, 1595 Wynkoop St, Denver, CO, 80202, United States.
authors.forename: David
authors.initials: D
authors.lastname: Berry
authors.affiliation: University of Cincinnati, Department of Environmental Health, 160 Panzeca Way, Cincinnati, OH, 45267, United States; University of Cincinnati, Department of Internal Medicine, Pulmonary Division, 160 Panzeca Way, Cincinnati, OH 45267, United States.
authors.forename: James
authors.initials: J
authors.lastname: Lockey
authors.affiliation: SRC Inc., Suite 1380, 999 18th St, Denver, CO, 80202, United States.
authors.forename: William
authors.initials: W
authors.lastname: Brattin
authors.affiliation: University of Cincinnati, Department of Environmental Health, 160 Panzeca Way, Cincinnati, OH, 45267, United States.
authors.forename: Timothy
authors.initials: T
authors.lastname: Hilbert
authors.affiliation: University of Cincinnati, Department of Environmental Health, 160 Panzeca Way, Cincinnati, OH, 45267, United States.
authors.forename: Grace
authors.initials: G
authors.lastname: LeMasters
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017636:Asbestos, Amphibole / Q000009:adverse effects*; D019985:Benchmarking; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015233:Models, Statistical; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects*; D016272:Occupational Health; D009820:Ohio; D010994:Pleura / Q000187:drug effects* / Q000473:pathology; D018570:Risk Assessment; D013997:Time Factors; D035501:Uncertainty; D055815:Young Adult
chemical_list: D017636:Asbestos, Amphibole
keywords: Asbestos; DPT; LAA; LPT; Libby amphibole; Pleural thickening; SIO