title: Effect of endometrial biopsy on intrauterine insemination outcome in controlled ovarian stimulation cycle.
abstract: OBJECTIVE
  The objective was to evaluate the effect of endometrial biopsy (EB) on intrauterine insemination (IUI) outcome in controlled ovarian stimulation (COS) cycle.
  
  
  METHODS
  Prospective randomized control study.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  A total of 251 subjects were enrolled in the study. Subjects undergoing COS with IUI were randomly allocated into three groups. Group A: EB was taken between D19 and 24 of the spontaneous menstrual cycles that precedes the fertility treatment and IUI, which was done in next cycle (n = 86). Group B: EB was taken before D6 of the menstrual cycle, and fertility treatment and IUI was done in the same cycle (n = 90). Group C: (control group) no EB in previous 3 cycle (n = 75).
  
  
  METHODS
  Clinical pregnancy rate (CPR).
  
  
  RESULTS
  Clinical pregnancy rate was 19.77%, 31.11%, and 9.3% for Group A, Group B, and Group C, respectively. The results show a highly significant value for the paired t-test of intervention Group B and control Group C of the cases (P = 0.000957). CPR was maximum after first cycle of ovulation induction and IUI following EB scratch in both Groups A and in Group B (P < 0.001).
  
  
  CONCLUSIONS
  Endometrial biopsy done in early follicular phase in the same cycle of stimulation with IUI gives better CPR as compared with EB done in the luteal phase of the previous cycle.
authors.affiliation: Department of Obstetrics and Gynecology, ESI-Post Graduate Institute of Medical Science and Research, Basaidarapur, New Delhi, India.
authors.forename: Leena
authors.initials: L
authors.lastname: Wadhwa
authors.affiliation: Department of Obstetrics and Gynecology, ESI-Post Graduate Institute of Medical Science and Research, Basaidarapur, New Delhi, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Pritam
authors.affiliation: Department of Obstetrics and Gynecology, ESI-Post Graduate Institute of Medical Science and Research, Basaidarapur, New Delhi, India.
authors.forename: Taru
authors.initials: T
authors.lastname: Gupta
authors.affiliation: Department of Obstetrics and Gynecology, ESI-Post Graduate Institute of Medical Science and Research, Basaidarapur, New Delhi, India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Department of Biochemistry, ESI-Post Graduate Institute of Medical Science and Research, Basaidarapur, New Delhi, India.
authors.forename: Sarika
authors.initials: S
authors.lastname: Arora
authors.affiliation: Department of Pathology, ESI-Post Graduate Institute of Medical Science and Research, Basaidarapur, New Delhi, India.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Chandoke
keywords: Assisted reproductive technology; controlled ovarian stimulation; endometrial biopsy; intrauterine insemination