title: Optic Nerve Sheath Melanoma Presenting as a Central Retinal Vein Occlusion.
abstract: A 64-year-old woman, with a history of diabetes and melanoma, developed a central retinal vein occlusion (CRVO) in her left eye. On exam, she had severe disc edema with retinal nerve fiber layer thickening, and anterior deformation of the peripapillary retinal pigment epithelium (RPE)/Bruch membrane layer (ppRPE/BM) toward the vitreous on spectral domain optical coherence tomography (SD-OCT) suggesting an optic nerve sheath (ONS) meningioma. Magnetic resonance imaging findings and ONS biopsy later confirmed a metastatic melanoma. This case demonstrates that the shape of the RPE/BM on SD-OCT may aid in the decision to consider imaging in patients with isolated CRVO.
authors.affiliation: Department of Ophthalmology (AB, PS, NB), Pathology (JED), and School of Medicine (NS), State University of New York at Stony Brook, Stony Brook, New York.
authors.forename: Alexander
authors.initials: A
authors.lastname: Barash
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Sibony
authors.forename: Nigel A
authors.initials: NA
authors.lastname: Stippa
authors.forename: Nariman S
authors.initials: NS
authors.lastname: Boyle
authors.forename: James E
authors.initials: JE
authors.lastname: Davis
mesh_terms: D016570:Bruch Membrane / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000556:secondary*; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D019574:Optic Nerve Neoplasms / Q000556:secondary*; D010211:Papilledema / Q000175:diagnosis; D012165:Retinal Ganglion Cells / Q000473:pathology; D012170:Retinal Vein Occlusion / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000473:pathology*; D041623:Tomography, Optical Coherence