title: Human pain and genetics: some basics.
abstract: Human pain causes untold misery and suffering, with major impact on functioning and resources. Recent advances in genetics have revealed that subtle changes in DNA could partly explain the variation in individual differences in pain. Various genes encoding for receptors are now known to play a major role in the sensitivity, perception and expression of pain. The fields of epigenetics and proteomics hold promises in the way pain could be treated and managed in future.
authors.affiliation: Department of Anaesthesia, Monklands Hospital, Airdrie, UK.
authors.forename: Sabu
authors.initials: S
authors.lastname: James
keywords: Chronic pain; congenital; fibromyalgia; genetics; hereditary sensory and autonomic neuropathies; musculoskeletal pain; nociceptive pain; pain; pain insensitivity; pain perception; post-operative; temporomandibular joint dysfunction syndrome