title: [Keloid scars (part I): Clinical presentation, epidemiology, histology and pathogenesis].
abstract: Keloid scars are a dysregulated response to cutaneous wound healing and are characterized by excessive deposition of collagen. Clinical and histological aspects are typical but they are often confused with hypertrophic scars. Principal pathogenesis is abnormal regulation of the collagen equilibrium because of TGFβ. In this first part, clinical characteristics, physiopathology and histology of keloid scars are explained.
authors.affiliation: Service de chirurgie plastique et réparatrice, hôpital Nord, AP-HM, CHU de Marseille, chemin des Bourrely, 13915 Marseille cedex 20, France. Electronic address: cecphil@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Philandrianos
authors.affiliation: Service de chirurgie plastique, CHRU La Cavale Blanche, boulevard Tanguy-Prigent, 29609 Brest, France.
authors.forename: N
authors.initials: N
authors.lastname: Kerfant
authors.affiliation: Service de chirurgie plastique et réparatrice, hôpital Nord, AP-HM, CHU de Marseille, chemin des Bourrely, 13915 Marseille cedex 20, France.
authors.forename: C
authors.initials: C
authors.lastname: Jaloux
authors.affiliation: Clinique Jules-Vernes, 2, route de Paris, 44300 Nantes, France.
authors.forename: L
authors.initials: L
authors.lastname: Martinet
authors.affiliation: Service de chirurgie plastique et réparatrice, hôpital Nord, AP-HM, CHU de Marseille, chemin des Bourrely, 13915 Marseille cedex 20, France.
authors.forename: B
authors.initials: B
authors.lastname: Bertrand
authors.affiliation: Service de chirurgie plastique et réparatrice, hôpital Nord, AP-HM, CHU de Marseille, chemin des Bourrely, 13915 Marseille cedex 20, France.
authors.forename: D
authors.initials: D
authors.lastname: Casanova
mesh_terms: D017209:Apoptosis; D003094:Collagen / Q000378:metabolism; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007627:Keloid / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D012307:Risk Factors; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016212:Transforming Growth Factor beta; D003094:Collagen
keywords: Chéloïde; Cicatrice; Collagen bundle; Collagène hyalin; Fibroblast; Fibroblaste; Fibrose; Fibrosis; Keloid; Scar; TGFβ