title: Microbial signatures in post-infectious irritable bowel syndrome--toward patient stratification for improved diagnostics and treatment.
abstract: Irritable bowel syndrome (IBS) is a multifactorial and heterogeneous disorder estimated to affect over 10% of the Western population. A subset of the patients reports the start of the disease after an episode of gastroenteritis. The alterations in the intestinal microbiota of the post-infectious IBS (PI-IBS) patients were recently investigated in a British cohort and shown to differentiate from the healthy controls and resemble that of diarrhea-predominant IBS (IBS-D) patients. The altered 27 genus-like groups created a microbial signature, which could be used to objectively stratify patients and healthy controls. In this addendum, we combine the microbiota data derived from the British cohort with that of a recently reported Swedish PI-IBS cohort. Remarkably, robust and reproducible microbiota signatures were observed in these PI-IBS patients. We discuss these results with attention on the emerging role of microbiota in the classification, development and treatment of PI-IBS.
authors.affiliation: a Department of Veterinary Biosciences ; Microbiology; University of Helsinki ; Helsinki , Finland.
authors.forename: Jonna
authors.initials: J
authors.lastname: Jalanka
authors.affiliation: b Department of Bacteriology and Immunology ; Immunobiology Research Program; University of Helsinki ; Helsinki , Finland.
authors.forename: Anne
authors.initials: A
authors.lastname: Salonen
authors.affiliation: c Laboratory of Microbiology; Wageningen University ; Wageningen , The Netherlands.
authors.forename: Susana
authors.initials: S
authors.lastname: Fuentes
authors.affiliation: a Department of Veterinary Biosciences ; Microbiology; University of Helsinki ; Helsinki , Finland.|b Department of Bacteriology and Immunology ; Immunobiology Research Program; University of Helsinki ; Helsinki , Finland.|c Laboratory of Microbiology; Wageningen University ; Wageningen , The Netherlands.
authors.forename: Willem M
authors.initials: WM
authors.lastname: de Vos
mesh_terms: D005243:Feces / Q000382:microbiology; D015870:Gene Expression; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000235:genetics / Q000382:microbiology* / Q000628:therapy; D064307:Microbiota
keywords: IMD; PI-IBS; irritable bowel syndrome; microbiota