title: Large-Scale Drug Screens Support Precision Medicine.
abstract: The major challenge underlying the emerging precision medicine initiative is to make links between cancer subsets and drugs that can be used to guide treatment of individual patients, leading to improved outcomes and decreased toxicity. Seashore-Ludlow and colleagues support this effort by reporting measurements of responses of 664 adherent cancer cell lines to 70 FDA-approved drugs, 100 experimental compounds, and 311 small-molecule probes. They use a novel Annotated Cluster Multidimensional Enrichment algorithm to identify drug mechanisms of action, molecular markers of response, responsive cancer subtypes, and compounds that produce synergistic cell inhibition.
authors.affiliation: Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon. grayjo@ohsu.edu.
authors.forename: Joe W
authors.initials: JW
authors.lastname: Gray
authors.affiliation: The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Gordon B
authors.initials: GB
authors.lastname: Mills
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D019295:Computational Biology / Q000379:methods; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000379:methods; D006801:Humans; D057285:Precision Medicine / Q000379:methods
chemical_list: D000970:Antineoplastic Agents