title: γ- and δ-Lactams from the Leaves of Clausena lansium.
abstract: Eight new clausenamides, including three γ-lactams (1-3), four δ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compound 2 (50 μM) protected 22.24% of cortical neurons against Aβ25-35-induced cell death.
authors.forename: De-Yang
authors.initials: DY
authors.lastname: Shen
authors.affiliation: Department of Chemistry, Vinh University , Vinh City, Vietnam.
authors.forename: Thi Ngan
authors.initials: TN
authors.lastname: Nguyen
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology , Tainan 71703, Taiwan.
authors.forename: Shwu-Jen
authors.initials: SJ
authors.lastname: Wu
authors.affiliation: Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine , Taipei 112, Taiwan.
authors.forename: Young-Ji
authors.initials: YJ
authors.lastname: Shiao
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Hung
authors.affiliation: Department of Biotechnology, National Formosa University , Yunlin 63201, Taiwan.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.affiliation: Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University , Pingtung 90741, Taiwan.
authors.forename: Daih-Huang
authors.initials: DH
authors.lastname: Kuo
authors.affiliation: Department of Chemistry, Vinh University , Vinh City, Vietnam.
authors.forename: Tran Dinh
authors.initials: TD
authors.lastname: Thang
authors.affiliation: Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University , Pingtung 90741, Taiwan.
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D016229:Amyloid beta-Peptides / Q000494:pharmacology; D002227:Carbazoles; D054700:Clausena / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010446:Peptide Fragments / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013237:Stereoisomerism; D014744:Vietnam
chemical_list: D016229:Amyloid beta-Peptides; D002227:Carbazoles; D007769:Lactams; D017705:Lignans; D018696:Neuroprotective Agents; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35); C053048:clausenamide