title: Synthesis and Antiviral Evaluation of Some C(3)-Symmetrical Trialkoxy-Substituted 1,3,5-Triazines and Their Molecular Geometry.
abstract: As one of our projects, we here report some new molecular modifications of 2,4,6-trichloro-1,3,5-triazine (TCTAZ: 1) to symmetrical 2,4,6-trialkoxy- or 2,4,6-triaryloxy-substituted 1,3,5-triazine (TAZ) molecules, as well as the results of anti-herpes simplex virus type 1 (anti-HSV-1) activity evaluation of synthesized 2,4,6-trisubstituted TAZ derivatives. Among the tested 2,4,6-trisubstituted TAZ derivatives, we reconfirmed that a C3-symmetrical TAZ derivative, 4e, shows the highest level of anti-HSV-1 activity with a good selectivity index. In this paper, we also report the results of the preparation of newly targeted TAZ derivatives and the structure-activity relationships (SARs) of these trialkoxy-substituted TAZ derivatives and related compounds. The sugar recognition properties of C3-symmetrical TAZ derivative 4e are also described.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Mibu
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yokomizo
authors.forename: Hatsumi
authors.initials: H
authors.lastname: Aki
authors.forename: Norimasa
authors.initials: N
authors.lastname: Ota
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujii
authors.forename: Ai
authors.initials: A
authors.lastname: Yuzuriha
authors.forename: Shiori
authors.initials: S
authors.lastname: Saneyoshi
authors.forename: Aoi
authors.initials: A
authors.lastname: Tanaka
authors.forename: Airi
authors.initials: A
authors.lastname: Koga
authors.forename: Jianrong
authors.initials: J
authors.lastname: Zhou
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miyata
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Sumoto
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006561:Herpes Simplex / Q000188:drug therapy*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D014227:Triazines