title: Prognostic Value of 18-Fluorodeoxyglucose-Positron Emission Tomography After Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma Undergoing Orthotopic Liver Transplantation.
abstract: BACKGROUND
  The aim of this study was to analyze the correlation between 18-FDG positron emission tomography (PET)/computed tomography (CT), histological necrosis, and prognosis after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) patients undergoing orthotopic liver transplantation (OLT).
  
  
  METHODS
  From January 2007 through December 2013, 81 patients with HCC and liver cirrhosis were included in our liver transplantation program. For this study we selected patients who underwent 18-FDG PET/CT pre-TACE and post-TACE. All patients underwent liver transplantation within 8 weeks after PET/CT.
  
  
  RESULTS
  Twenty patients with a median age of 58 years (range, 46-69 years) underwent an 18-FDG PET/CT before and after TACE. The median Standardized Uptake Value (SUV) before TACE was 3.8 (range, 2.6-8.7), with a median post-TACE SUV of 0% (range, 0-4). Among patients whose post-TACE SUV decreased to <3, >70% necrosis was observed upon study of a hepatectomy sample, with a survival rate of 100% and 80% at 1 and 3 years, respectively.
  
  
  CONCLUSIONS
  In conclusion, performance of an 18-FDG PET/CT before and after TACE with comparison of SUV values among patients with HCC awaiting OLT provided valuable information regarding the effectiveness of TACE.
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: P A
authors.initials: PA
authors.lastname: Cascales-Campos
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain. Electronic address: ramirezp@um.es.
authors.forename: P
authors.initials: P
authors.lastname: Ramírez
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Lopez
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Gonzalez
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Saenz-Mateos
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Llacer
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Sánchez Bueno
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Robles
authors.affiliation: Department of Hepatology, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Pons
authors.affiliation: Department of Radiology, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Capel
authors.affiliation: Department of Nuclear Medicine, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Frutos
authors.affiliation: Department of Nuclear Medicine, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Navarro
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Muñoz-Ramon
authors.affiliation: Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Parrilla
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D003131:Combined Modality Therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000628:therapy*; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009336:Necrosis; D049268:Positron-Emission Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18