title: Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation.
abstract: Innate lymphoid cells (ILCs) 'preferentially' localize into barrier tissues, where they function in tissue protection but can also contribute to inflammatory diseases. The mechanisms that regulate the establishment of ILCs in barrier tissues are poorly understood. Here we found that under steady-state conditions, ILCs in skin-draining lymph nodes (sLNs) were continuously activated to acquire regulatory properties and high expression of the chemokine receptor CCR10 for localization into the skin. CCR10(+) ILCs promoted the homeostasis of skin-resident T cells and, reciprocally, their establishment in the skin required T cell-regulated homeostatic environments. CD207(+) dendritic cells expressing the transcription factor Foxn1 were required for the proper generation of CCR10(+) ILCs. These observations reveal mechanisms that underlie the specific programming and priming of skin-homing CCR10(+) ILCs in the sLNs.
authors.affiliation: Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Shaomin
authors.initials: S
authors.lastname: Hu
authors.affiliation: Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Luming
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Kaplan
authors.affiliation: Center for Molecular Toxicology &Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Gary H
authors.initials: GH
authors.lastname: Perdew
authors.affiliation: Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Na
authors.initials: N
authors.lastname: Xiong
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D005434:Flow Cytometry; D006706:Homeostasis / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D054447:Receptors, CCR10 / Q000276:immunology*; D012867:Skin / Q000276:immunology*
chemical_list: C515707:Ccr10 protein, mouse; D054447:Receptors, CCR10