title: Photocrosslinking of styrene-butadiene-styrene (SBS) networks formed by thiol-ene reactions and their influence on cell survival.
abstract: Styrene-butadiene-styrene (SBS) triblock copolymer has been conventionally used as synthetic rubber. However, the potential of SBS for biomedical applications has only been considered in limited earlier reports. Here, we demonstrate an effective approach to designing a photocrosslinked SBS network. Rheological analysis has been conducted for the investigation of the storage modulus of the resultant network. Crosslinked SBS networks were synthesized and characterized through optical and electron microscope imaging. The crosslink density of the network, calculated from swelling experiments, was 643 mol m(-3), where higher swelling in a hydrophobic medium was observed compared to the swelling measured in water. Cell survival analysis with HeLa cells and NIH/3T3 fibroblasts revealed that these networks are non-toxic, and that they could be considered for a variety of biomedical applications.
authors.forename: Dogan
authors.initials: D
authors.lastname: Gidon
authors.forename: Derya
authors.initials: D
authors.lastname: Aydin
authors.forename: Seda
authors.initials: S
authors.lastname: Kizilel
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000633:toxicity*; D002070:Butadienes / Q000737:chemistry* / Q000528:radiation effects / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects*; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000528:radiation effects / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D006801:Humans; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D013343:Styrenes / Q000737:chemistry* / Q000633:toxicity*; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000528:radiation effects
chemical_list: D001672:Biocompatible Materials; D002070:Butadienes; D003432:Cross-Linking Reagents; D013343:Styrenes; D013438:Sulfhydryl Compounds