title: Evaluation Frequency of Merkel Cell Polyoma, Epstein-Barr and Mouse Mammary Tumor Viruses in Patients with Breast Cancer in Kerman, Southeast of Iran.
abstract: Breast cancer is the most common cancer among women worldwide. Roles of the Epstein-Barr, Merkel cell polyoma and mouse mammary tumor viruses in breast carcinogenesis are still controversial although any relationship would clearly be important for breast cancer etiology, early detection and prevention. In the present study associations between EBV, MMTV and Merkel cell polyoma virus and breast cancer in 100 Iranian patients were evaluated using paraffin-embedded tissues. EBER RNA and expression of p53 and large T antigen were evaluated by real time PCR and CD34, p63, HER2, PR and ER markers were studied by immunohistochemistry. EBV was detected in 8/100 (8%), MMTV in 12/100 (12%), MPy in 3/100 (3%) and EBER RNA in 18/100 (18%) cases. None of the control samples demonstrated any of the viruses. p53 was suppressed in EBV, MPy and MMTV positive samples. The large T antigen rate was raised in MPy positive samples. Our results showed that EBV, MMTV and the Merkel cell polyoma virus are foundwith some proportion of breast cancers in our patients, suggesting that these viruses might have a significant role in breast cancer in Kerman, southeast of Iran.
authors.affiliation: Kerman University of Medical sciences, Afzalipour School of Medicine, Research Center of Infectious and Tropical Diseases, Kerman, Iran E-mail : hamid2008kmu@gmail.com.
authors.forename: Malekpour Afshar
authors.initials: MA
authors.lastname: Reza
authors.forename: Mollaie Hamid
authors.initials: MH
authors.lastname: Reza
authors.forename: Lashkarizadeh
authors.initials: L
authors.lastname: Mahdiyeh
authors.forename: Fazlalipour
authors.initials: F
authors.lastname: Mehdi
authors.forename: Zeinali Nejad
authors.initials: ZN
authors.lastname: Hamid
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology / Q000821:virology; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000473:pathology / Q000821:virology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000150:complications / Q000473:pathology / Q000821:virology; D015266:Carcinoma, Merkel Cell / Q000453:epidemiology* / Q000821:virology; D004279:DNA, Viral; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D006801:Humans; D008324:Mammary Tumor Virus, Mouse / Q000472:pathogenicity; D059965:Merkel cell polyomavirus / Q000472:pathogenicity; D051379:Mice; D008875:Middle Aged; D060787:Neoplasm Grading; D027601:Polyomavirus Infections / Q000453:epidemiology* / Q000821:virology; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D012189:Retrospective Studies; D012192:Retroviridae Infections / Q000453:epidemiology* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000821:virology
chemical_list: D004279:DNA, Viral; D012333:RNA, Messenger