title: Galactosylated Polymer Nano-objects by Polymerization-Induced Self-Assembly, Potential Drug Nanocarriers.
abstract: Glycopolymer-based nanostructures are invaluable tools to both study biological phenomena and to design future targeted drug delivery systems. Polymerization-induced self-assembly, especially RAFT aqueous dispersion polymerization is a unique method to prepare such polymer nanostructures, as it enables the preparation of very-well-defined morphologies at very high concentrations. Here we describe the implementation of PISA to the synthesis of galactosylated spheres, wormlike micelles and vesicles, and the preliminary results of cell toxicity, cell uptake, and cargo delivering capacity of galactose-decorated vesicles.
authors.affiliation: IEM (Institut Européen des Membranes), UMR 5635 (CNRS-ENSCM-UM), Université de Montpellier, CC047, Place E. Bataillon, 34095, Montpellier, France.
authors.forename: Mona
authors.initials: M
authors.lastname: Semsarilar
authors.affiliation: The Centre for Stem Cell Biology (CSCB), The University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.|The Centre for Membrane Interactions and Dynamics (CMIAD), Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, S10 2TN, Uk.
authors.forename: Irene
authors.initials: I
authors.lastname: Canton
authors.affiliation: ICGM (Institut Charles Gerhardt) UMR 5253 (CNRS-ENSCM-UM), Université de Montpellier, CC047, Place E. Bataillon, 34095, Montpellier, France. vincent.ladmiral@enscm.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Ladmiral
mesh_terms: D002460:Cell Line; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D005690:Galactose / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D006001:Glycoconjugates; D011109:Polymethacrylic Acids; D005690:Galactose
keywords: Cell uptake; Glycopolymers; Polymerization-induced self-assembly; RAFT polymerization