title: A flow injection chemiluminescence method for determination of nalidixic acid based on KMnO₄-morin sensitized with CdS quantum dots.
abstract: A simple and sensitive flow injection chemiluminescence (CL) method was developed for determination of nalidixic acid by application of CdS quantum dots (QDs) in KMnO4-morin CL system in acidic medium. Optical and structural features of L-cysteine capped CdS quantum dots which were synthesized via hydrothermal approach were investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM), photoluminescence (PL), and ultraviolet-visible (UV-Vis) spectroscopy. Moreover, the potential mechanism of the proposed CL method was described using the results of the kinetic curves of CL systems, the spectra of CL, PL and UV-Vis analyses. The CL intensity of the KMnO4-morin-CdS QDs system was considerably increased in the presence of nalidixic acid. Under the optimum condition, the enhanced CL intensity was linearly proportional to the concentration of nalidixic acid in the range of 0.0013 to 21.0 mg L(-1), with a detection limit of (3σ) 0.003 mg L(-1). Also, the proposed CL method was utilized for determination of nalidixic acid in environmental water samples, and commercial pharmaceutical formulation to approve its applicability. Furthermore, corona discharge ionization ion mobility spectrometry (CD-IMS) method was utilized for determination of nalidixic acid and the results of real sample analysis by two proposed methods were compared. Comparison the analytical features of these methods represented that the proposed CL method is preferable to CD-IMS method for determination of nalidixic acid due to its high sensitivity and precision.
authors.affiliation: Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran. Electronic address: a_khataee@tabrizu.ac.ir.
authors.forename: Alireza
authors.initials: A
authors.lastname: Khataee
authors.affiliation: Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Lotfi
authors.affiliation: Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, 51666-16471 Tabriz, Iran.
authors.forename: Aliyeh
authors.initials: A
authors.lastname: Hasanzadeh
authors.affiliation: Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111 Maragheh, Iran.
authors.forename: Mortaza
authors.initials: M
authors.lastname: Iranifam
authors.affiliation: School of Mechanical Engineering, Yeungnam University, 712-749 Gyeongsan, South Korea. Electronic address: swjoo@yu.ac.kr.
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Joo
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D019187:Cadmium Compounds / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry; D004784:Environmental Monitoring / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D005419:Flavonoids / Q000737:chemistry*; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods; D060587:Groundwater / Q000032:analysis; D057230:Limit of Detection; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D009268:Nalidixic Acid / Q000032:analysis*; D011196:Potassium Permanganate / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry* / Q000648:ultrastructure; D013440:Sulfides / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis*; D047309:Flavones
chemical_list: D000900:Anti-Bacterial Agents; D019187:Cadmium Compounds; D003545:Cysteine; D005419:Flavonoids; D009268:Nalidixic Acid; D011196:Potassium Permanganate; D013440:Sulfides; D014874:Water Pollutants, Chemical; C034939:cadmium sulfide; C008548:morin; D047309:Flavones
keywords: CdS quantum dots; Chemiluminescence; Flow injection; Nalidixic acid