title: The Relationship between Galectin-3 and Different Patterns of Ventricular Geometry Remodelling in Aortic Valve Stenosis.
abstract: BACKGROUND
  This study was conducted to assess expression of Galectin-3 (Gal-3) in patients with different types of left ventricle (LV) hypertrophy geometry, and the relationship between Gal-3 expression and LV remodelling in patients with aortic valve stenosis (AS).
  
  
  METHODS
  Galectin-3 expression was measured in the plasma and myocardia of AS patients who underwent an aortic valve replacement procedure.
  
  
  RESULTS
  The study enrolled 77 consecutive patients with severe AS. Fifty-five (71.43%) of the enrolled patients had concentric hypertrophy (CH group), and had the highest degree of fibrosis (27.10±5.25%; p<0.001) and expression of Gal-3 in both plasma (19.11±2.06 ng/mL) and myocardial tissue (3.01±0.79). There was a strong positive correlation between the levels of fibrosis and Gal-3 expression in both plasma (r=0.584, p<0.001) and myocardium (r=0.522, p<0.001). Relative wall thickness (RWT) was strongly correlated with Gal-3 expression in both myocardium (r=0.594, p<0.001) and plasma (r=0.323, p=0.005). Additionally, N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were positively correlated with both fibrosis (r=0.313, p=0.036) and LV mass index (r=0.559, p<0.001).
  
  
  CONCLUSIONS
  Concentric hypertrophy geometry was the most common type of myocardium remodelling, and AS patients with CH geometry showed the highest levels of Gal-3 expression. Galectin-3 levels were positively correlated with fibrosis and RWT, both of which are crucial indicators of geometric remodelling. Galectin-3 and NT-proBNP levels may be valuable prognostic predictors in AS patients with myocardial remodelling.
authors.affiliation: The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Zhou
authors.affiliation: The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
authors.forename: Yangzhao
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
authors.forename: Changming
authors.initials: C
authors.lastname: Tan
authors.affiliation: The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
authors.forename: Zhaoshun
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Li
authors.affiliation: The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Liao
authors.affiliation: The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Gu
authors.affiliation: The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China. Electronic address: mark090103@163.com.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000328:Adult; D001024:Aortic Valve Stenosis / Q000097:blood* / Q000473:pathology*; D001798:Blood Proteins; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D037161:Galectins; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D020257:Ventricular Remodeling
chemical_list: D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Aortic stenosis; Fibrosis; Galectin-3; Myocardial hypertrophy; Myocardial remodelling