title: Genetic association of GWAS-supported MAD1L1 gene polymorphism rs12666575 with schizophrenia susceptibility in a Chinese population.
abstract: Schizophrenia (SCZ) is a severe neuropsychiatric disorder with high heritability. A recent European genome-wide association study has reported that mitotic arrest deficient-like 1 (MAD1L1) polymorphism rs12666575 is associated with SCZ susceptibility. This study aims to test the association of MAD1L1 variant rs12666575 with SCZ susceptibility in a Chinese population. A total of 1400 participants, which include 700 SCZ patients and 700 sex- and age-matched controls (Zhuang: 300, Han: 400, respectively), were genotyped using the Sequenom MassARRAY iPLEX platform. 591 SCZ patients underwent positive and negative syndrome scale (PANSS) assessment. Genetic association analysis was performed using the PLINK program. The results showed MAD1L1 rs12666575 polymorphism was significantly associated with SCZ susceptibility in the recessive model (p(adj)=0.013). Also, rs12666575 was significantly associated with general psychopathology sub-scale score (p(adj)=0.043) and thought disturbance factor score (p(adj)=0.045). Our data suggested that MAD1L1 rs12666575 polymorphism may play a protective role against SCZ in the Chinese population. Furthermore, rs12666575 may be associated with general psychopathology and thought disturbance in SCZ patients.
authors.affiliation: School of Public Health of Guangxi Medical University, Nanning, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Nanning, Guangxi, China. Electronic address: suli2018@hotmail.com.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Shen
authors.affiliation: School of Public Health of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Guifeng
authors.initials: G
authors.lastname: Huang
authors.affiliation: School of Public Health of Guangxi Medical University, Nanning, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Nanning, Guangxi, China.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Long
authors.affiliation: Pre-Clinical Faculty of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Fan
authors.affiliation: School of Public Health of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Ling
authors.affiliation: School of Public Health of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
chemical_list: D018797:Cell Cycle Proteins; C501384:MAD1L1 protein, human; D009687:Nuclear Proteins
keywords: MAD1L1; Polymorphism; Schizophrenia; rs12666575