title: Ethyl-³H analogues of plant natural products: Biologically active proxy radioligands via vinyl group tritiation.
abstract: Methods are presented to tritiate the plant natural product analogues dihydrocolforsin and dihydroquinidine.
authors.affiliation: PerkinElmer Health Sciences, Inc., 940 Winter St, Waltham, MA 02451, United States.
authors.forename: Demetri
authors.initials: D
authors.lastname: Orphanos
authors.affiliation: PerkinElmer Health Sciences, Inc., 940 Winter St, Waltham, MA 02451, United States. Electronic address: crist.filer@perkinelmer.com.
authors.forename: Crist N
authors.initials: CN
authors.lastname: Filer
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D005576:Colforsin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D007553:Isotope Labeling / Q000379:methods*; D028321:Plant Preparations / Q000737:chemistry; D011802:Quinidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D011869:Radioligand Assay; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry; D014316:Tritium / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D001688:Biological Products; D028321:Plant Preparations; D019275:Radiopharmaceuticals; D014753:Vinyl Compounds; D014316:Tritium; D005576:Colforsin; C014486:hydroquinidine; D011802:Quinidine
keywords: Dihydrocolforsin; Dihydroquinidine; Tritium; Tritium NMR