title: The Clinicopathologic Characteristics and 5-year Survival Rate of Epithelial Ovarian Cancer in Yazd, Iran.
abstract: BACKGROUND
  Ovarian cancer is the second most common malignancy in women, the most common cause of gynecologic cancer deaths, and most patients have advanced stage disease at the time of diagnosis. The purpose of this study was to estimate the 5-year survival of patients with epithelial ovarian cancer based on age, tumor histology, stage of disease, and type of treatment.
  
  
  METHODS
  This study was conducted on 120 patients with epithelial ovarian cancer referred to Shahid Sadoughi hospital and Shah Vali oncology clinic of Yazd from 2006 to 2012. Demographic data and patient records were studied to evaluate the treatment outcome, pathology of the tumor, and stage of disease. Finally, the overall survival rate and tumor-free survival of patients was assessed.
  
  
  RESULTS
  The mean patient age was 53.87± 14.11 years. Most participants had stage I (36.7%) or stage II (35%) disease. Serous adenocarcinoma (57.6%) was the most common pathology found in patients with epithelial ovarian cancer. The overall survival of patients in this study was significantly associated with the histological tumor type (p = 0.000) and disease stage (p = 0.0377). Stage I (84.18%) and serous adenocarcinoma (72.81%) demonstrated the best survival. The tumor-free survival rates were not associated with histology types (p = 0.079), surgical procedure (p = 0.18), or chemotherapy (p = 0.18).
  
  
  CONCLUSIONS
  The survival of patients with epithelial ovarian cancer was significantly associated with disease stage. Serous adenocarcinoma also had the best prognosis among the pathologies studied. Therefore, early detection of ovarian cancer can substantially increase the survival rate.
authors.affiliation: Gynecology Oncology Fellowship, Assistant Professor, Gynecology Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Karimi-Zarchi
authors.affiliation: Oncologist, Associate Professor, Department of Oncology and Hematology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Seyed Mohammad Reza
authors.initials: SM
authors.lastname: Mortazavizadeh
authors.affiliation: Epidemiologist, Professor, Epidemiology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Bashardust
authors.affiliation: Medical Student, Student Research Committee, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Zakerian
authors.affiliation: M.Sc. of Health Education, Faculty of Hygiene, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mahbube
authors.initials: M
authors.lastname: Zaidabadi
authors.affiliation: Medical Student, Student Research Committee, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Pouria
authors.initials: P
authors.lastname: Yazdian-Anari
authors.affiliation: Medical Student, Young Researchers and Elites Club, Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran.
authors.forename: Soraya
authors.initials: S
authors.lastname: Teimoori
keywords: Epithelial ovarian cancer; epidemiologic points; survival rate; tumor pathology