title: Cell-free DNA as a prognostic marker in stage I non-small-cell lung cancer patients undergoing stereotactic body radiotherapy.
abstract: OBJECTIVE
  To evaluate whether plasma cell-free DNA (cfDNA) was related to clinical outcome in inoperable stage I non-small cell lung cancer (NSCLC) patients undergoing stereotactic body radiotherapy (SBRT).
  
  
  METHODS
  Plasma cfDNA was assessed at baseline, before the last day and 45 days after the end of SBRT, in 22 NSCLC patients. Twenty-two healthy controls were also evaluated.
  
  
  RESULTS
  Plasma cfDNA was higher in patients than in controls. An association with unfavourable disease-free survival was found for continuous baseline cfDNA increments (HR = 5.9, 95%CI: 1.7-19.8, p = 0.04).
  
  
  CONCLUSIONS
  Plasma cfDNA may be a promising prognostic biomarker in high-risk NSCLC patients.
authors.affiliation: a Microbiology-Immunology and Virology Unit, Oncology Reference Center, IRCCS , Aviano (PN) , Italy .
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Bortolin
authors.affiliation: a Microbiology-Immunology and Virology Unit, Oncology Reference Center, IRCCS , Aviano (PN) , Italy .
authors.forename: Rosamaria
authors.initials: R
authors.lastname: Tedeschi
authors.affiliation: b Epidemiology and Biostatistic Unit, Oncology Reference Center, IRCCS , Aviano (PN) , Italy .
authors.forename: Ettore
authors.initials: E
authors.lastname: Bidoli
authors.affiliation: c Medical Radiotherapy Department, Oncology Reference Center, IRCCS , Aviano (PN) , Italy , and.
authors.forename: Carlo
authors.initials: C
authors.lastname: Furlan
authors.affiliation: a Microbiology-Immunology and Virology Unit, Oncology Reference Center, IRCCS , Aviano (PN) , Italy .
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Basaglia
authors.affiliation: c Medical Radiotherapy Department, Oncology Reference Center, IRCCS , Aviano (PN) , Italy , and.
authors.forename: Emilio
authors.initials: E
authors.lastname: Minatel
authors.affiliation: c Medical Radiotherapy Department, Oncology Reference Center, IRCCS , Aviano (PN) , Italy , and.
authors.forename: Carlo
authors.initials: C
authors.lastname: Gobitti
authors.affiliation: c Medical Radiotherapy Department, Oncology Reference Center, IRCCS , Aviano (PN) , Italy , and.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Franchin
authors.affiliation: c Medical Radiotherapy Department, Oncology Reference Center, IRCCS , Aviano (PN) , Italy , and.
authors.forename: Marco
authors.initials: M
authors.lastname: Trovò
authors.affiliation: d Scientific Directorate, Oncology Reference Center, IRCCS , Aviano (PN) , Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: De Paoli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000235:genetics / Q000601:surgery*; D004273:DNA, Neoplasm / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000235:genetics / Q000601:surgery*; D008297:Male; D011379:Prognosis; D016634:Radiosurgery / Q000379:methods; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
keywords: Biomarker; cell-free DNA; early stage; lung cancer; stereotactic body radiotherapy