title: [Endocrine disorders and osteoporosis].
abstract: Secondary osteoporosis is a bone disease characterized by decreased bone mass that predisposes fractures due to underlying disorders or medication. Disorders of the endocrine system, such as primary hyperparathyroidism, hyperthyroidism, hypogonadism, growth hormone deficiency, Cushing's syndrome, and anorexia nervosa frequently cause secondary osteoporosis. In those diseases, hormone excess or deficiency affects functions of osteoblasts, osteocyte, and osteoclasts, leading to aberrant bone remodeling. Bisphosphonates are the first-choice pharmacological agents for fracture prevention in most patients with secondary osteoporosis along with treatment of the underlying disease.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D016723:Bone Remodeling; D004164:Diphosphonates / Q000627:therapeutic use; D004700:Endocrine System Diseases / Q000150:complications*; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology; D015431:Weight Loss
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates