title: Prognostic Significance of NT-proBNP Levels in Patients over 65 Presenting Acute Myocardial Infarction Treated Invasively or Conservatively.
abstract: OBJECTIVE
  Assessment of prognostic significance of NT-proBNP level and the effects of invasive (I) and conservative (C) treatment of acute myocardial infarction (AMI) in patients over 65.
  
  
  METHODS
  One-year survival was assessed in 286 consecutive patients with AMI aged 65-100 (79 ± 8) subjected to I or C treatment (136 and 150 individuals), respectively.
  
  
  RESULTS
  245 (85%) patients survived in-hospital stay: 124 (91.1%) received I treatment and 121 (80.6%) received C treatment. Heart failure (HF) was diagnosed in 30 patients receiving I treatment (22.6%) and in 71 subjected to C treatment (47.3%), p < 0,0001. NT-proBNP levels in the latter group were significantly higher than in the 185 patients without HF (12311 ± 13560 pg/mL versus 4773 ± 8807 pg/mL, p < 0.0001). NT-proBNP levels after coronary angioplasty were lower than in patients receiving C treatment (5922 ± 10250 pg/mL versus 8718 ± 12024 pg/mL, p = 0.0002). Left ventricular ejection fraction was significantly higher in I patients than in C patients (47 ± 13% versus 42 ± 11.6%, p = 0.004). During the one-year follow-up, 82.3% of I patients and 61.2% of the C patients survived (p < 0.0003). There was a significantly lower probability of death at NT-proBNP below 8548.5 pg/mL.
  
  
  CONCLUSIONS
  The NT-proBNP level in the first day of AMI is a good prognosticator. One-year follow-up prognosis for patients who received I treatment in the AMI is better than that for C patients. I patients exhibit superior left ventricular function after angioplasty and in the follow-up.
authors.affiliation: Cardiology Clinic of Physiotherapy Division of The 2nd Faculty of Medicine, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80 Street, 02-903 Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Drewniak
authors.affiliation: Cardiology Clinic of Physiotherapy Division of The 2nd Faculty of Medicine, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80 Street, 02-903 Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Szybka
authors.affiliation: Cardiology Clinic of Physiotherapy Division of The 2nd Faculty of Medicine, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80 Street, 02-903 Warsaw, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Bielecki
authors.affiliation: Cardiology Clinic of Physiotherapy Division of The 2nd Faculty of Medicine, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80 Street, 02-903 Warsaw, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Malinowski
authors.affiliation: Cardiology Clinic of Physiotherapy Division of The 2nd Faculty of Medicine, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80 Street, 02-903 Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kotlarska
authors.affiliation: Cardiology Clinic of Physiotherapy Division of The 2nd Faculty of Medicine, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80 Street, 02-903 Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Krol-Jaskulska
authors.affiliation: Cardiology Clinic of Physiotherapy Division of The 2nd Faculty of Medicine, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80 Street, 02-903 Warsaw, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Popielarz-Grygalewicz
authors.affiliation: Cardiology Clinic of Physiotherapy Division of The 2nd Faculty of Medicine, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80 Street, 02-903 Warsaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Konwicka
authors.affiliation: Cardiology Clinic of Physiotherapy Division of The 2nd Faculty of Medicine, Medical University of Warsaw, Bielanski Hospital, Ceglowska 80 Street, 02-903 Warsaw, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Dąbrowski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain