title: Revisiting HELLP syndrome.
abstract: HELLP syndrome was first described in 1982 by Weinstein et al. and the term HELLP refers to an acronym used to describe the clinical condition that leads to hemolysis, elevated liver enzymes and low platelets. The syndrome frequency varies from 0.5 to 0.9% pregnancies and manifests preferentially between the 27th and 37th week of gestation. Approximately 30% of cases occur after delivery. Although the etiopathogenesis of this syndrome remains unclear, histopathologic findings in the liver include intravascular fibrin deposits that presumably may lead to hepatic sinusoidal obstruction, intrahepatic vascular congestion, and increased intrahepatic pressure with ensuing hepatic necrosis, intraparenchymal and subcapsular hemorrhage, and eventually capsular rupture. Typical clinical symptoms of HELLP syndrome are pain in the right upper quadrant abdomen or epigastric pain, nausea and vomiting. However, this syndrome can present nonspecific symptoms and the diagnosis may be difficult to be established. Laboratory tests and imaging exams are essential for differential diagnosis with other clinical conditions. Treatment of HELLP syndrome with corticosteroids, targeting both lung maturation of the fetus is still an uncertain clinical value. In conclusion, three decades after the tireless efforts of Dr. Weinstein to characterize HELLP syndrome, it remains a challenge to the scientific community and several questions need to be answered for the benefit of pregnant women.
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Brazil. Electronic address: lucidusse@gmail.com.
authors.forename: Luci Maria
authors.initials: LM
authors.lastname: Dusse
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Patrícia Nessralla
authors.initials: PN
authors.lastname: Alpoim
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Juliano Teixeira
authors.initials: JT
authors.lastname: Silva
authors.affiliation: Campus Centro Oeste Dona Lindu, Universidade Federal de São João Del-Rei, Brazil.
authors.forename: Danyelle Romana Alves
authors.initials: DR
authors.lastname: Rios
authors.affiliation: Centro de Medicina Fetal - Hospital das Clínicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Augusto Henriques
authors.initials: AH
authors.lastname: Brandão
authors.affiliation: Centro de Medicina Fetal - Hospital das Clínicas, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Antônio Carlos Vieira
authors.initials: AC
authors.lastname: Cabral
mesh_terms: D005260:Female; D017359:HELLP Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D011247:Pregnancy
keywords: Differential diagnosis; Glycemia; HELLP syndrome; Laboratorial tests; Preeclampsia; Treatment