title: Chemical sporulation and germination: cytoprotective nanocoating of individual mammalian cells with a degradable tannic acid-FeIII complex.
abstract: Individual mammalian cells were coated with cytoprotective and degradable films by cytocompatible processes maintaining the cell viability. Three types of mammalian cells (HeLa, NIH 3T3, and Jurkat cells) were coated with a metal-organic complex of tannic acid (TA) and ferric ion, and the TA-Fe(III) nanocoat effectively protected the coated mammalian cells against UV-C irradiation and a toxic compound. More importantly, the cell proliferation was controlled by programmed formation and degradation of the TA-Fe(III) nanocoat, mimicking the sporulation and germination processes found in nature.
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 34141, Korea. ischoi@kaist.ac.kr.
authors.forename: Juno
authors.initials: J
authors.lastname: Lee
authors.forename: Hyeoncheol
authors.initials: H
authors.lastname: Cho
authors.forename: Jinsu
authors.initials: J
authors.lastname: Choi
authors.forename: Doyeon
authors.initials: D
authors.lastname: Kim
authors.forename: Daewha
authors.initials: D
authors.lastname: Hong
authors.forename: Ji Hun
authors.initials: JH
authors.lastname: Park
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Yang
authors.forename: Insung S
authors.initials: IS
authors.lastname: Choi
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D005290:Ferric Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D051379:Mice; D041681:NIH 3T3 Cells; D013473:Sunscreening Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D013634:Tannins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D005290:Ferric Compounds; D013473:Sunscreening Agents; D013634:Tannins