title: Good's Syndrome: Successful Management of Thymoma With Hypoimmunoglobulinemia.
abstract: We report a case of Good's syndrome managed with surgery and immunotherapy in a 58-year-old man who presented with a left arm skin infection and cough for 2 months. Imaging and laboratory studies revealed a large anterior mediastinal mass and panhypoimmunoglobulinemia, respectively. A biopsy was consistent with thymoma, and a diagnosis of Good's syndrome was established. Thymectomy was followed by intravenous immunoglobulin G and filgrastim with complete recovery through 9 months after discharge. Good's syndrome remains a rare entity often associated with poor prognosis. Adequate surgical resection remains key to outcomes, whereas immunotherapy aids in reducing postoperative complications and may improve survival.
authors.affiliation: Departments of Surgery and Cardiothoracic Surgery, Santa Barbara Cottage Hospital, Santa Barbara, California. Electronic address: zachdeboard@gmail.com.
authors.forename: Zachary M
authors.initials: ZM
authors.lastname: DeBoard
authors.affiliation: Departments of Surgery and Cardiothoracic Surgery, Santa Barbara Cottage Hospital, Santa Barbara, California.
authors.forename: Benedict J W
authors.initials: BJ
authors.lastname: Taylor
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications*; D003131:Combined Modality Therapy; D000069585:Filgrastim / Q000627:therapeutic use; D006401:Hematologic Agents / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000601:surgery*; D013953:Thymus Neoplasms / Q000150:complications / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D006401:Hematologic Agents; D016756:Immunoglobulins, Intravenous; D000069585:Filgrastim