title: [Treatments around surgery of prostate cancer and surgery of recurrence].
abstract: OBJECTIVE
  To describe neoadjuvant and adjuvant treatments to surgery and the place of surgery in the recurrence after primary treatments.
  
  
  METHODS
  Bibliography search was performed from the database Medline (National Library of Medicine, Pubmed), selected according to the scientific relevance. The research was focused on treatments before and after surgery, biological recurrence and surgery as the procedure in case of failure of other treatments of non-metastatic prostate cancer.
  
  
  RESULTS
  Main oncological objectif of surgery is to decrease positive surgical margins by good adequation between technics and tumor and patient status. Neoadjuvant treatments are today disappointing; however, adjuvant radiotherapy and hormonotherapy demonstrated their interest in case of extracapsular extension, positive margins or invasion of lymph nodes. Nevertheless, superiority of adjuvant treatment to salvage treatment is still debated. Radical prostatectomy is still the only curative treatment in case of failure of another localized treatment.
  
  
  CONCLUSIONS
  Radical prostatectomy has to be one of the main references of localized prostate cancer treatments especially in case of multimodal approach. Pathological exam of specimen and postoperative PSA value should precise the optimal management of prostate cancer.
authors.affiliation: Service d'urologie et de transplantation rénale et pancréatique, CHU Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France. Electronic address: laurent.salomon@aphp.fr.
authors.forename: L
authors.initials: L
authors.lastname: Salomon
authors.affiliation: Clinique Saint-Jean du Languedoc, route de Revel, 31400 Toulouse, France.
authors.forename: G
authors.initials: G
authors.lastname: Ploussard
authors.affiliation: Service de radiothérapie, hôpital Saint-Louis, 42, rue Bichat, 75010 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
authors.affiliation: Institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Richaud
authors.affiliation: Département d'urologie-andrologie-transplantation rénale, CHU Rangueil, 1, avenue Jean-Poulhès, 31059 Toulouse cedex 9, France.
authors.forename: M
authors.initials: M
authors.lastname: Soulié
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery* / Q000628:therapy; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000601:surgery* / Q000628:therapy
keywords: Active surveillance; Adjuvant radiotherapy; Adjuvant treatment; Biological recurrence; Cancer de la prostate; Chemotherapy; Chimiothérapie; Chirurgie; Cryotherapy; Cryothérapie; Curage ganglionnaire; HIFU; Hormonotherapy; Hormonothérapie; Lymph node excision; Marges chirurgicales; Neoadjuvant treatment; Prostate cancer; Prostatectomie totale; Radical prostatectomy; Radiothérapie adjuvante; Radiothérapie de sauvetage; Récidive biologique; Salvage radiotherapy; Surgery; Surgical margins; Surveillance active; Traitement néoadjuvant; Traitements adjuvants