title: Nasopharyngeal Capillary Arteriovenous Malformation with Ancient/Symplastic Change: A Simulator of Malignancy.
abstract: There are only 8 published cases of symplastic hemangioma (SH), a relatively recently described, distinct benign entity characterized by pleomorphic vascular smooth muscle and interstitial cells in a pre-existing, long-standing vascular lesion. Seven of these cases were of SH in cutaneous locations, and 1 case was described in the mediastinum. We report the case of the 12-year-old girl with a nasopharyngeal tumor mass with prominent symplastic changes arising in the background of a combined capillary arteriovenous malformation. After critical analysis of all published cases of SH, it is clear that these lesions commonly represent capillary arteriovenous malformations (CAVM) with ancient/symplastic changes according to current terminology proposed in the classification required by the International Society for the Study of Vascular Anomalies (ISSVA). This is the first such lesion reported in a mucosal location and presenting in the pediatric age group. CAVM with ancient/symplastic change follows a benign clinical course, but it can simulate a malignant vascular tumor.
authors.affiliation: 1 Department of Clinical Pathology, Mother and Child Health Care Institute of Serbia Dr Vukan Cupic, Belgrade, Serbia.
authors.forename: Gordana
authors.initials: G
authors.lastname: Samardzija
authors.affiliation: 1 Department of Clinical Pathology, Mother and Child Health Care Institute of Serbia Dr Vukan Cupic, Belgrade, Serbia.|2 Banjaluka University School of Medicine, Banjaluka, Bosnia and Herzegovina.
authors.forename: Slavisa M
authors.initials: SM
authors.lastname: Djuricic
authors.affiliation: 3 Department of Otorhinolaryngology, Mother and Child Health Care Institute of Serbia Dr Vukan Cupic, Belgrade, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Baljosevic
authors.affiliation: 4 Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, United Kingdom.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Calonje
mesh_terms: D001165:Arteriovenous Malformations / Q000473:pathology*; D002196:Capillaries / Q000002:abnormalities*; D002648:Child; D005260:Female; D006801:Humans; D009302:Nasopharyngeal Diseases / Q000473:pathology*
keywords: diagnosis; nasopharynx; pathogenesis; symplastic hemangioma; vascular malformation