title: SERPINE1 rs1799768 polymorphism contributes to sepsis risk and mortality.
abstract: BACKGROUND
  The present meta-analysis aimed to investigate whether there is an association between SERPINE1 rs1799768 polymorphism and sepsis risk and mortality.
  
  
  METHODS
  Published reports were searched in PubMed, PubMed Central, Gene, PubChem and Google Scholar. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were assessed in a random-effects model.
  
  
  RESULTS
  The results of the overall meta-analysis indicated that an increased sepsis risk was evidently associated with SERPINE1 rs1799768 polymorphism (OR = 1.30; 95% CI 1.08-1.56; p = 0.006). When studies were stratified by ethnicity, no significant association was observed between SERPINE1 rs1799768 polymorphism and sepsis risk in the Asian group. As for the Caucasian population, overall OR was 1.24 (95% CI 1.02-1.51; p = 0.03). The results of the overall meta-analysis indicated that an increased sepsis mortality risk was evidently associated with SERPINE1 rs1799768 polymorphism (OR = 1.73; 95% CI 1.31-2.28; p < 0.0001). When studies were stratified by ethnicity, significant association was observed between SERPINE1 rs1799768 polymorphism and sepsis risk mortality in the Asian group and the Caucasian population.
  
  
  CONCLUSIONS
  In conclusion, the meta-analysis suggests that there are significant associations between SERPINE1 rs1799768 polymorphism and risk of sepsis and sepsis mortality.
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, China.
authors.forename: Qiankun
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: Mu
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Hong
authors.affiliation: Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, China zhenshuyunnj@163.com.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Zheng
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D018805:Sepsis / Q000235:genetics* / Q000401:mortality*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human
keywords: SERPINE1; Sepsis; meta-analysis; polymorphism