title: Surgical and Anesthetic Management of a Mediastinal Fatty Tumor: Lipoblastoma.
abstract: Lipoblastoma is a rare fatty tumor that is diagnosed almost exclusively in children. Presentation often consists of respiratory symptoms; chest computed tomography shows a hypodense, low, attenuated mediastinal mass. Surgical approach and anesthetic management are dependent on the location of the tumor and the degree of airway compression; in most cases, a thoracotomy is performed, although a sternotomy is used in selected cases. Final diagnosis can be confirmed using molecular genetic analysis; a genetic hallmark of lipoblastoma is the rearrangement of chromosomal region 8q12 and the PLAG1 gene. Tumor recurrence is rare when a complete resection is performed.
authors.affiliation: Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Ghada
authors.initials: G
authors.lastname: Al-Mubarak
authors.affiliation: Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: abryant@uab.edu.
authors.forename: Ayesha S
authors.initials: AS
authors.lastname: Bryant
authors.affiliation: Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Jack H
authors.initials: JH
authors.lastname: Crawford
authors.affiliation: Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Dukes
authors.affiliation: Department of Pathology, Children's of Alabama, Birmingham, Alabama.
authors.forename: David R
authors.initials: DR
authors.lastname: Kelly
authors.affiliation: Department of Radiology, Children's of Alabama, Birmingham, Alabama.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Young
authors.affiliation: Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: David C
authors.initials: DC
authors.lastname: Cleveland
mesh_terms: D000768:Anesthesia, General / Q000379:methods*; D001706:Biopsy; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D006801:Humans; D007223:Infant; D062689:Lipoblastoma / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D056346:Sternotomy / Q000379:methods*; D014057:Tomography, X-Ray Computed