title: Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents.
abstract: Besides acting as antimicrobial compounds, dendrimers can be considered as agents that improve the therapeutic effectiveness of existing antibiotics. In this work we present a new approach to using amoxicillin (AMX) against reference strains of common Gram-negative pathogens, alone and in combination with poly(propylene imine) (PPI) dendrimers, or derivatives thereof, in which 100% of the available hydrogen atoms are substituted with maltose (PPI 100%malG3). The concentrations of dendrimers used remained in the range non-toxic to eukaryotic cells. The results indicate that PPI dendrimers significantly enhance the antibacterial effect of amoxicillin alone, allowing antibiotic doses to be reduced. It is important to reduce doses of amoxicillin because its widespread use in medicine could lead to the development of bacterial resistance and environmental pollution. This is the first report on the combined antibacterial activity of PPI surface-modified maltose dendrimers and amoxicillin.
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland. nwronska@biol.uni.lodz.pl.
authors.forename: Natalia
authors.initials: N
authors.lastname: Wrońska
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland. afrycie@biol.uni.lodz.pl.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Felczak
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland. zawadzka@biol.uni.lodz.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Zawadzka
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland. n37@o2.pl.
authors.forename: Martyna
authors.initials: M
authors.lastname: Poszepczyńska
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland. rozalska@biol.uni.lodz.pl.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Różalska
authors.affiliation: Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143, Pomorska Street, 90-236 Lodz, Poland. marbrys@biol.uni.lodz.pl.
authors.forename: Maria
authors.initials: M
authors.lastname: Bryszewska
authors.affiliation: Leibniz Institute of Polymer Research Dresden, Hohe Street 6, 01069 Dresden, Germany. applhans@ipfdd.de.
authors.forename: Dietmar
authors.initials: D
authors.lastname: Appelhans
authors.affiliation: Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland. katalis@biol.uni.lodz.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Lisowska
mesh_terms: D000658:Amoxicillin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D050091:Dendrimers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011126:Polypropylenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D050091:Dendrimers; D011126:Polypropylenes; C443641:poly(propyleneimine); D000658:Amoxicillin
keywords: amoxicillin; antibacterial activity; poly(propylene imine) dendrimers