title: Endosomal integrin signals for survival.
abstract: The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.
authors.affiliation: Cancer Research UK, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
authors.forename: Elena
authors.initials: E
authors.lastname: Rainero
authors.affiliation: Cancer Research UK, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
authors.forename: Jim C
authors.initials: JC
authors.lastname: Norman
mesh_terms: D000818:Animals; D023102:Anoikis / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism*; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism*; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D019012:Integrin beta1; D051417:Focal Adhesion Kinase 1