title: No Promoter Left Behind (NPLB): learn de novo promoter architectures from genome-wide transcription start sites.
abstract: Promoters have diverse regulatory architectures and thus activate genes differently. For example, some have a TATA-box, many others do not. Even the ones with it can differ in its position relative to the transcription start site (TSS). No Promoter Left Behind (NPLB) is an efficient, organism-independent method for characterizing such diverse architectures directly from experimentally identified genome-wide TSSs, without relying on known promoter elements. As a test case, we show its application in identifying novel architectures in the fly genome.
  
  
  
  Web-server at http://nplb.ncl.res.in Standalone also at https://github.com/computationalBiology/NPLB/ (Mac OSX/Linux).
  
  
  
  l.narlikar@ncl.res.in
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Chemical Engineering Division, CSIR-National Chemical Laboratory, Pune 411008, India.
authors.forename: Sneha
authors.initials: S
authors.lastname: Mitra
authors.affiliation: Chemical Engineering Division, CSIR-National Chemical Laboratory, Pune 411008, India.
authors.forename: Leelavati
authors.initials: L
authors.lastname: Narlikar
mesh_terms: D016678:Genome; D011401:Promoter Regions, Genetic; D024363:Transcription Initiation Site