title: Traffic aerosol lobar doses deposited in the human respiratory system.
abstract: Aerosol pollution in urban environments has been recognized to be responsible for important pathologies of the cardiovascular and respiratory systems. In this perspective, great attention has been addressed to Ultra Fine Particles (UFPs < 100 nm), because they efficiently penetrate into the respiratory system and are capable of translocating from the airways into the blood circulation. This paper describes the aerosol regional doses deposited in the human respiratory system in a high-traffic urban area. The aerosol measurements were carried out on a curbside in downtown Rome, on a street characterized by a high density of autovehicular traffic. Aerosol number-size distributions were measured by means of a Fast Mobility Particle Sizer in the range from 5.6 to 560 nm with a 1 s time resolution. Dosimetry estimates were performed with the Multiple-Path Particle Dosimetry model by means of the stochastic lung model. The exposure scenario close to traffic is represented by a sequence of short-term peak exposures: about 6.6 × 1010particles are deposited hourly into the respiratory system. After 1 h of exposure in proximity of traffic, 1.29 × 1010, 1.88 × 1010, and 3.45 × 1010particles are deposited in the head, tracheobronchial, and alveolar regions. More than 95 % of such doses are represented by UFPs. Finally, according to the greater dose estimated, the right lung lobes are expected to be more susceptible to respiratory pathologies than the left lobes.
authors.affiliation: DIT, INAIL Research Area, via IV Novembre 144, I-00187, Rome, Italy. m.manigrasso@inail.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Manigrasso
authors.affiliation: DIT, INAIL Research Area, via IV Novembre 144, I-00187, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Vernale
authors.affiliation: DIT, INAIL Research Area, via IV Novembre 144, I-00187, Rome, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Avino
mesh_terms: D000336:Aerosols / Q000493:pharmacokinetics*; D000393:Air Pollutants; D006801:Humans; D008168:Lung / Q000737:chemistry*; D010316:Particle Size; D012137:Respiratory System; D001335:Vehicle Emissions
chemical_list: D000336:Aerosols; D000393:Air Pollutants; D001335:Vehicle Emissions
keywords: Deposition doses; FMPS; Lung lobes; MPPD; Ultrafine particles; Urban air