title: Review of seizure outcomes after surgical resection of dysembryoplastic neuroepithelial tumors.
abstract: Dysembryoplastic neuroepithelial tumors (DNETs) are rare tumors that present with seizures in the majority of cases. We report the results of a review of seizure freedom rates following resection of these benign lesions. We searched the English literature using PubMed for articles presenting seizure freedom rates for DNETs as a unique entity. Patient demographics, tumor characteristics, and operative variables were assessed across selected studies. Twenty-nine articles were included in the analysis. The mean age at surgery across studies was a median of 18 years (interquartile range 11-25 years). The mean duration of epilepsy pre-operatively was a median 7 years (interquartile range 3-11 years). Median reported gross-total resection rate across studies was 79% (interquartile range 62-92%). Authors variously chose lesionectomy or extended lesionectomy operations within and across studies. The median seizure freedom rate was 86% (interquartile range 77-93%) with only one study reporting fewer than 60% of patients seizure free. Seizure outcomes were either reported at 1 year of follow-up or at last follow-up, which occurred at a median of 4 years (interquartile range 3-7 years). The number of seizure-free patients who discontinued anti-epileptic drugs varied widely from zero to all patients. Greater extent of resection was associated with seizure freedom in four studies.
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd., Suite 4000, Oklahoma City, OK, 73104, USA.
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Bonney
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd., Suite 4000, Oklahoma City, OK, 73104, USA.
authors.forename: Lillian B
authors.initials: LB
authors.lastname: Boettcher
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd., Suite 4000, Oklahoma City, OK, 73104, USA.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Conner
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd., Suite 4000, Oklahoma City, OK, 73104, USA.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Glenn
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd., Suite 4000, Oklahoma City, OK, 73104, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Briggs
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd., Suite 4000, Oklahoma City, OK, 73104, USA.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Santucci
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd., Suite 4000, Oklahoma City, OK, 73104, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Bellew
authors.affiliation: Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: James D
authors.initials: JD
authors.lastname: Battiste
authors.affiliation: Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd., Suite 4000, Oklahoma City, OK, 73104, USA. mes261@columbia.edu.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Sughrue
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000150:complications* / Q000601:surgery; D019635:Neurosurgical Procedures / Q000379:methods*; D039781:PubMed / Q000706:statistics & numerical data; D012640:Seizures / Q000209:etiology* / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Dysembryoplastic neuroepithelial tumor; Glioneuronal tumor; Resection; Review; Seizure; Surgery