title: Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep.
abstract: Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 (Nf1) to regulate growth and associative learning in flies. We show that Alk mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of Alk on sleep to the mushroom body, a structure important for both sleep and memory. We also report that mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes.
authors.affiliation: Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
authors.forename: Lei
authors.initials: L
authors.lastname: Bai
authors.affiliation: Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.|Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
authors.forename: Amita
authors.initials: A
authors.lastname: Sehgal
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D000818:Animals; D004330:Drosophila / Q000502:physiology*; D024521:Mushroom Bodies / Q000201:enzymology*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D012890:Sleep / Q000502:physiology*
chemical_list: D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases