title: Estimation of Pyruvic acid in serum and saliva among healthy and potentially malignant disorder subjects - a stepping stone for cancer screening?
abstract: BACKGROUND
  According to Warburg's effect, the rate of glycolysis increases in cancerous cells. This will increase overall levels of pyruvic acid. The present on-going study was conducted to estimate the levels of pyruvic acid in saliva and serum in normal, oral PMD subjects.
  
  
  METHODS
  A total of 50 subjects in healthy, PMD of the oral cavity individuals were selected based on clinical and histological criteria. Collected saliva and serum samples were subjected to pyruvic acid level estimation using biochemical analysis.
  
  
  RESULTS
  Of the 50 participants 25 (13: Males; 12: Females) & 25 (16: Males; 9: Females) were PMD group. Independent samples t test showed statistically significant difference in serum & salivary pyruvic acid level in between 2 groups (p < 0.001 respectively).
  
  
  CONCLUSIONS
  Estimation of pyruvic acid showed sequential increase in the level in PMD group compared to healthy. Hence the study results open new direction in cancer screening.
  
  
  BACKGROUND
  Pyruvic acid, glycolysis, warburg's effect.
authors.affiliation: MBBS, Post Graduate, Department of Radiology, S.D.M. College of Medical Sciences & Hospital, Sattur, Dharwad-580009, India.
authors.forename: Anithraj
authors.initials: A
authors.lastname: Bhat
authors.affiliation: MDS, Asst. Professor, Department of Public Health Dentistry, KVG Dental College and Hospital, Sullia, D.K.
authors.forename: Manohara
authors.initials: M
authors.lastname: Bhat
authors.affiliation: Professor & Head, Department of Public Health Dentistry, S.D.M. College of Dental Sciences & Hospital, Sattur, Dharwad-580009, India.
authors.forename: Kakarla
authors.initials: K
authors.lastname: Prasad
authors.affiliation: Professor & Head, Department of Biochemistry, S.D.M. College of Dental Sciences & Hospital, Sattur, Dharwad-580009, India.
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Trivedi
authors.affiliation: Post Graduate, Department of Pharmacology, Vijayanagara Institute of Medical Sciences, Bellary, India.
authors.forename: Swathi
authors.initials: S
authors.lastname: Acharya