title: First-pass myocardial perfusion imaging with whole-heart coverage using L1-SPIRiT accelerated variable density spiral trajectories.
abstract: To design and evaluate two-dimensional (2D) L1-SPIRiT accelerated spiral pulse sequences for first-pass myocardial perfusion imaging with whole heart coverage capable of measuring eight slices at 2 mm in-plane resolution at heart rates up to 125 beats per minute (BPM).
  
  
  
  Combinations of five different spiral trajectories and four k-t sampling patterns were retrospectively simulated in 25 fully sampled datasets and reconstructed with L1-SPIRiT to determine the best combination of parameters. Two candidate sequences were prospectively evaluated in 34 human subjects to assess in vivo performance.
  
  
  
  A dual density broad transition spiral trajectory with either angularly uniform or golden angle in time k-t sampling pattern had the largest structural similarity and smallest root mean square error from the retrospective simulation, and the L1-SPIRiT reconstruction had well-preserved temporal dynamics. In vivo data demonstrated that both of the sampling patterns could produce high quality perfusion images with whole-heart coverage.
  
  
  
  First-pass myocardial perfusion imaging using accelerated spirals with optimized trajectory and k-t sampling pattern can produce high quality 2D perfusion images with whole-heart coverage at the heart rates up to 125 BPM. Magn Reson Med 76:1375-1387, 2016. © 2015 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA.|Department of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Kramer
authors.affiliation: Department of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Shaw
authors.affiliation: Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia, USA.|Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA.
authors.forename: Craig H
authors.initials: CH
authors.lastname: Meyer
authors.affiliation: Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, Virginia, USA. ms5pc@virginia.edu.|Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia, USA. ms5pc@virginia.edu.|Department of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia, USA. ms5pc@virginia.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Salerno
mesh_terms: D000465:Algorithms; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
keywords: L1-SPIRiT; cardiac MRI; compressed sensing; k-t sampling pattern; myocardial perfusion; spiral pulse sequences