title: Computed tomography findings of hepatic veno-occlusive disease caused by Sedum aizoon with histopathological correlation.
abstract: This study investigated the value of computed tomography (CT) in the diagnosis and treatment of hepatic veno-occlusive disease (HVOD) caused by Sedum aizoon (SA). The clinical manifestations, treatment results, imaging findings, and histological findings of the liver were analyzed in 39 patients with HVOD caused by SA. Hepatomegaly, liver dysfunction, abdominal effusion, and geographic density changes on liver CT scans were found in all 39 patients. The pathological findings of histological liver examination included swelling and point-like necrosis of liver cells, significant expansion and congestion of the sinuses, endothelial swelling, and wall thickening with incomplete lumen occlusion of small liver vessels. CT geographic density changes were confirmed by histological examination of the liver in 18 patients. Sixteen patients with small amounts of ascites that started within 4 weeks of treatment recovered completely or significantly improved after symptomatic and supportive treatment. However, only 43.75% of the patients with larger amounts of ascites improved following symptomatic and supportive treatment. In conclusion, liver CT examination is a valuable, safe, and noninvasive tool for the diagnosis of HVOD caused by SA. In selected cases, liver CT examination may replace liver biopsy and histological analysis.
authors.affiliation: Department of Infectious Diseases, Taizhou Hospital Affiliated to Wenzhou Medical College, Linhai, China.
authors.forename: H
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Infectious Diseases, Taizhou Hospital Affiliated to Wenzhou Medical College, Linhai, China.
authors.forename: H Z
authors.initials: HZ
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, Taizhou Hospital Affiliated to Wenzhou Medical College, Linhai, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Zhu
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: B
authors.initials: B
authors.lastname: Ruan
authors.affiliation: Department of Infectious Disease, Xianju Hospital of Traditional Chinese Medicine, Xianju, China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, Taizhou Hospital Affiliated to Wenzhou Medical College, Linhai, China.
authors.forename: X
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Infectious Diseases, Taizhou Hospital Affiliated to Wenzhou Medical College, Linhai, China.
authors.forename: M F
authors.initials: MF
authors.lastname: Gan
mesh_terms: D000328:Adult; D000368:Aged; D001201:Ascites / Q000209:etiology; D001706:Biopsy; D002681:China; D004365:Drugs, Chinese Herbal / Q000506:poisoning*; D005260:Female; D006504:Hepatic Veno-Occlusive Disease / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012189:Retrospective Studies; D031963:Sedum / Q000145:classification / Q000506:poisoning*; D014057:Tomography, X-Ray Computed
chemical_list: D004365:Drugs, Chinese Herbal