title: Quantitative cancer risk assessment for occupational exposures to asphalt fumes during built-up roofing asphalt (BURA) operations.
abstract: The International Agency for Research on Cancer qualitatively characterized occupational exposure to oxidized bitumen emissions during roofing as probably carcinogenic to humans (Group 2A). We examine chemistry, exposure, epidemiology and animal toxicity data to explore quantitative risks for roofing workers applying built-up roofing asphalt (BURA). Epidemiology studies do not consistently report elevated risks, and generally do not have sufficient exposure information or adequately control for confounders, precluding their use for dose-response analysis. Dermal carcinogenicity bioassays using mice report increased tumor incidence with single high doses. In order to quantify potential cancer risks, we develop time-to-tumor model methods [consistent with U.S. Environmental Protection Agency (EPA) dose-response analysis and mixtures guidelines] using the dose-time-response shape of concurrent exposures to benzo[a]pyrene (B[a]P) as concurrent controls (which had several exposure levels) to infer presumed parallel dose-time-response curves for BURA-fume condensate. We compare EPA relative potency factor approaches, based on observed relative potency of BURA to B[a]P in similar experiments, and direct observation of the inferred BURA dose-time-response (scaled to humans) as means for characterizing a dermal unit risk factor. We apply similar approaches to limited data on asphalt-fume inhalation and respiratory cancers in rats. We also develop a method for adjusting potency estimates for asphalts that vary in composition using measured fluorescence. Overall, the various methods indicate that cancer risks to roofers from both dermal and inhalation exposure to BURA are within a range typically deemed acceptable within regulatory frameworks. The approaches developed may be useful in assessing carcinogenic potency of other complex mixtures of polycyclic aromatic compounds.
authors.affiliation: a Gradient , Cambridge , MA , USA and.
authors.forename: Lorenz R
authors.initials: LR
authors.lastname: Rhomberg
authors.affiliation: b Gradient , Seattle , WA , USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Mayfield
authors.affiliation: a Gradient , Cambridge , MA , USA and.
authors.forename: Julie E
authors.initials: JE
authors.lastname: Goodman
authors.affiliation: a Gradient , Cambridge , MA , USA and.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Butler
authors.affiliation: a Gradient , Cambridge , MA , USA and.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Nascarella
authors.affiliation: a Gradient , Cambridge , MA , USA and.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Williams
mesh_terms: D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000818:Animals; D015197:Carcinogenicity Tests; D003252:Construction Materials; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006801:Humans; D006838:Hydrocarbons / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D018570:Risk Assessment; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects; D012878:Skin Neoplasms / Q000139:chemically induced / Q000453:epidemiology
chemical_list: D000395:Air Pollutants, Occupational; D006838:Hydrocarbons; D011084:Polycyclic Aromatic Hydrocarbons; C006647:asphalt
keywords: Asphalt; benzo[a]pyrene; carcinogenicity; epidemiology; polycyclic aromatic hydrocarbon; relative potency factor; risk assessment; time to tumor