title: NUTRITIONAL AND METABOLIC ASSESSMENT IN OVERWEIGHT PATIENTS WITH AND WITHOUT HYPERPROLACTINEMIA CAUSED BY PROLACTINOMA.
abstract: BACKGROUND
  prolactinomas are pituitary adenomas that express and secrete prolactin. These patients are overweight and the mechanisms are being studied.
  
  
  OBJECTIVE
  assess nutritional and metabolic status of overweight patients with and without hyperprolactinemia caused by prolactinoma and compare them.
  
  
  METHODS
  cross-sectional study, patients with body mass index (BMI) ≥ 25 kg/m2 with and without prolactinoma: 1) 20 normoprolactinemic (NPrl) with prolactinoma; 2) 23 hyperprolactinemic (HPrl) with prolactinoma; 3) 28 controls without prolactinoma or alterations in prolactin levels. Evaluated through anthropometric, dietetics, and biochemical assessment.
  
  
  RESULTS
  of the 71 patients evaluated, most were obese women with macroprolactinomas. All three groups had diets with low caloric and monounsaturated fatty acid (MUFA) intake, the NPrl group had low carbohydrate (CHO) intake and high lipid (LIP) and saturated fatty acid (SFA) intake, and the NPrl and HPrl groups had appropriate intake of polyunsaturated fatty acids (PUFA). The HPrl group had elevated total cholesterol. HDL cholesterol was below the recommended threshold for most patients. No statistically significant differences were found in anthropometric and biochemical variables among the groups.
  
  
  CONCLUSIONS
  most patients with prolactinomas and controls are obese and metabolically similar regardless of prolactin levels. All groups presented low caloric and MUFA intake. Protein, LIP, SFA, and cholesterol were significantly different among the groups, the NPrl group ingested less amount of protein and greater of fat. Snacking between meals and changes of food consumption on weekends was reported by most patients. This is the first study comparing patients with prolactinomas and controls, both with overweight, regarding food consumption and feeding behavior.
authors.affiliation: Federal University of Health Sciences of Porto Alegre (UFCSPA).. brunabreyer@hotmail.com.
authors.forename: Bruna
authors.initials: B
authors.lastname: Breyer Freitas
authors.affiliation: Federal University of Health Sciences of Porto Alegre (UFCSPA).. renataer@hotmail.com.
authors.forename: Renata Elisabeth
authors.initials: RE
authors.lastname: Rothen
authors.affiliation: Neuroendocrinology Center of Santa Casa of Porto Alegre, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre.. debora_zeni@hotmail.com.
authors.forename: Débora
authors.initials: D
authors.lastname: Zeni
authors.affiliation: Neuroendocrinology Center of Santa Casa of Porto Alegre, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre.. carolinagsleaes@gmail.com.
authors.forename: Carolina
authors.initials: C
authors.lastname: Garcia Soares Leães
authors.affiliation: Federal University of Health Sciences of Porto Alegre (UFCSPA). Neuroendocrinology Center of Santa Casa of Porto Alegre, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre.. mco@ufcspa.com.br.
authors.forename: Miriam
authors.initials: M
authors.lastname: Costa Oliveira
authors.affiliation: Department of Nutrition, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil.. fernandab@ufcspa.edu.br.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Michielin Busnello
authors.affiliation: Federal University of Health Sciences of Porto Alegre (UFCSPA). Neuroendocrinology Center of Santa Casa of Porto Alegre, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre.. jpereiralima@terra.com.br.
authors.forename: Júlia
authors.initials: J
authors.lastname: Fernanda Semmelmann Pereira-Lima
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004032:Diet; D004435:Eating; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000209:etiology* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D009765:Obesity / Q000209:etiology / Q000378:metabolism; D050177:Overweight / Q000150:complications* / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism*; D015175:Prolactinoma / Q000150:complications* / Q000378:metabolism*