title: Modeling TMS-induced I-waves in human motor cortex.
abstract: Despite many years of research, it is still unknown how exactly transcranial magnetic stimulation activates cortical circuits. A recent computational model by Rusu et al. (2014) has attempted to shed light on potential underlying mechanisms and has successfully explained key experimental findings on I-wave physiology. Here, we critically discuss this model, point out some of its shortcomings, and suggest a number of extensions that may be necessary for it to capture additional existing and emerging data on the physiology of I-waves.
authors.affiliation: Frankfurt Institute for Advanced Studies, Goethe University, Frankfurt, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Triesch
authors.affiliation: Department of Neurology & Stroke, Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Zrenner
authors.affiliation: Department of Neurology & Stroke, Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Germany. Electronic address: ulf.ziemann@uni-tuebingen.de.
authors.forename: Ulf
authors.initials: U
authors.lastname: Ziemann
mesh_terms: D058256:Brain Waves / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009044:Motor Cortex / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
keywords: Computational modeling; Corticospinal neuron; I-waves; Motor cortex; Transcranial magnetic stimulation