title: The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment.
abstract: Subcortical vascular cognitive impairment (SVCI) refers to cognitive impairment associated with small vessel disease. Motor intentional disorders (MID) have been reported in patients with SVCI. However, there are no studies exploring the neuroanatomical regions related to MID in SVCI patients. The aim of this study, therefore, was to investigate the neural correlates of MID in SVCI patients. Thirty-one patients with SVCI as well as 10 healthy match control participants were included. A "Pinch-Grip" apparatus was used to quantify the force control capabilities of the index finger in four different movement phases including initiation, development, maintenance, and termination. All participants underwent magnetic resonance imaging (MRI). Topographical cortical areas and white matter tracts correlated with the performances of the four different movement phases were assessed by the surface-based morphometry and tract-based spatial statistics analyses. Poorer performance in the maintenance task was related to cortical thinning in bilateral dorsolateral prefrontal, orbitofrontal and parietal cortices, while poorer performance in the termination task was associated with the disruption of fronto-parietal cortical areas as well as the white matter tracts including splenium and association fibers such as superior longitudinal fasciculus. Our study demonstrates that cortical areas and underlying white matter tracts associated with fronto-parietal attentional system play an important role in motor impersistence and perseveration in SVCI patients.
authors.affiliation: Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.|Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.|Ewha Brain Institute, Ewha Womans University, Seoul, Korea.
authors.forename: Geon Ha
authors.initials: GH
authors.lastname: Kim
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.|Neuroscience Center, Samsung Medical Center, Seoul, Korea.|Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
authors.affiliation: School of Industrial Engineering, University of Ulsan, Ulsan, Korea.
authors.forename: Kihyo
authors.initials: K
authors.lastname: Jung
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
authors.forename: Oh-Hun
authors.initials: OH
authors.lastname: Kwon
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
authors.forename: Hunki
authors.initials: H
authors.lastname: Kwon
authors.affiliation: Department of Neurology, National Health Insurance Corporation, Ilsan Hospital, Goyang, Korea.
authors.forename: Jong Hun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jee Hoon
authors.initials: JH
authors.lastname: Roh
authors.affiliation: Department of Neurology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.|Neuroscience Center, Samsung Medical Center, Seoul, Korea.
authors.forename: Byung Hwa
authors.initials: BH
authors.lastname: Lee
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.|Neuroscience Center, Samsung Medical Center, Seoul, Korea.
authors.forename: Doo Sang
authors.initials: DS
authors.lastname: Yoon
authors.affiliation: Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea.
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Hwang
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.
authors.forename: Jee Hyang
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Industrial and Management Engineering, Pohang University of Science and Technology, Pohang, Korea.
authors.forename: Heecheon
authors.initials: H
authors.lastname: You
authors.affiliation: Department of Neurology, University of Florida College of Medicine, and the Veterans Affairs Medical Center, Gainesville, FL, USA.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Heilman
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dukna@skku.edu.|Neuroscience Center, Samsung Medical Center, Seoul, Korea. dukna@skku.edu.|Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea. dukna@skku.edu.
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002540:Cerebral Cortex / Q000473:pathology*; D059345:Cerebral Small Vessel Diseases / Q000150:complications*; D060825:Cognitive Dysfunction / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D003337:Corpus Callosum / Q000473:pathology; D005260:Female; D005385:Fingers / Q000503:physiopathology; D006801:Humans; D033182:Intention; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009434:Neural Pathways / Q000473:pathology; D066127:White Matter / Q000473:pathology*
keywords: Cortical thickness; Motor intentional disorder; Subcortical vascular cognitive impairment; Tract-based spatial statistics