title: Influence of Periodontal Therapy on Systemic Lipopolysaccharides in Children with Localized Aggressive Periodontitis.
abstract: OBJECTIVE
  A previous study has shown that children with localized aggressive periodontitis (LAP) demonstrate a lipopolysaccharide (LPS) hyper-responsiveness in addition to elevated levels of systemic LPS when compared to periodontally healthy children. The purpose of this study was to evaluate whether periodontal therapy modulates systemic lipopolysaccharide levels and whether these levels may influence clinical outcomes.
  
  
  METHODS
  Peripheral blood samples and clinical parameters (probing depth [PD], clinical attachment levels [CAL], percent sites greater than four mm, bleeding on probing [BoP], and visible plaque [P]) were collected from 29 LAP patients prior to and at three, six, and 12 months following scaling and root planning and systemic antibiotics. Serum LPS levels were quantified using a chromogenic assay.
  
  
  RESULTS
  Twenty-five patients were compliant with the prescribed antibiotic treatment and demonstrated a significant reduction in LPS as well as overall PD, CAL, and plaque at all time points post-therapy. Additionally LPS reductions correlated with reductions in PD, CAL, and plaque.
  
  
  CONCLUSIONS
  Localized aggressive periodontitis therapy with antibiotics plays an important role in reducing systemic lipopolysaccharide levels. Since LPS is a key mediator of the LAP hyperinflammatory response, its systemic reduction is especially important for the successful management of these children.
authors.affiliation: Department of Periodontology, the College of Dentistry, University of Florida, Gainesville, Fla., USA.
authors.forename: D
authors.initials: D
authors.lastname: Kalash
authors.affiliation: Department of Periodontology, the College of Dentistry, University of Florida, Gainesville, Fla., USA.
authors.forename: A
authors.initials: A
authors.lastname: Vovk
authors.affiliation: Department of Periodontology, the College of Dentistry, University of Florida, Gainesville, Fla., USA.
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Periodontology, the College of Dentistry, University of Florida, Gainesville, Fla., USA.
authors.forename: I
authors.initials: I
authors.lastname: Aukhil
authors.affiliation: Department of Periodontology and Department of Oral Biology, the College of Dentistry, University of Florida, Gainesville, Fla., USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Wallet
authors.affiliation: Department of Periodontology and Department of Oral Biology, the College of Dentistry, University of Florida, Gainesville, Fla., USA. lshaddox@dental.ufl.edu.
authors.forename: L M
authors.initials: LM
authors.lastname: Shaddox
mesh_terms: D000293:Adolescent; D010520:Aggressive Periodontitis / Q000628:therapy*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D012534:Dental Scaling; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides / Q000097:blood*; D008297:Male; D016745:Root Planing
chemical_list: D000900:Anti-Bacterial Agents; D008070:Lipopolysaccharides