title: Bisphenol-A promotes antiproliferative effects during neonatal prostate development in male and female gerbils.
abstract: The aim of this study was to evaluate the development of male and female neonatal gerbil prostate under normal conditions and exposed to bisphenol-A (BPA). Normal postnatal development of the female gerbil prostate occurs earlier than and is morphologically distinct from that occurring in males. In BPA-exposed PND8 gerbils, we have not observed evidence of alterations in the ductal branching in either gender. However, the exposure to BPA alters the immunolabeling pattern of AR, ERα, and PCNA. In males, the exposure to high dosages of BPA resulted in a decrease in the proliferative status of the developing ventral prostate. In females, both high and low dosages were sufficient to decrease the proliferation of paraurethral buds in the branching process by more than 50%. Therefore, the obtained data indicate that BPA promotes antiproliferative effects during the neonatal development of the gerbil prostate, with more sensitivity to this endocrine disruptor in females.
authors.affiliation: Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil.
authors.forename: Rodrigo Fernandes
authors.initials: RF
authors.lastname: de Lima
authors.affiliation: Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil.
authors.forename: Daniel Andrés Osório
authors.initials: DA
authors.lastname: Rodriguez
authors.affiliation: São Paulo State University - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, 2265, São José do Rio Preto, São Paulo 15054000, Brazil.
authors.forename: Mônica Souza
authors.initials: MS
authors.lastname: Campos
authors.affiliation: Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil.
authors.forename: Manoel Francisco
authors.initials: MF
authors.lastname: Biancardi
authors.affiliation: Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil.
authors.forename: Iana Figueiredo Ferreira Roriz
authors.initials: IF
authors.lastname: dos Santos
authors.affiliation: Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil.
authors.forename: Wendyson Duarte
authors.initials: WD
authors.lastname: de Oliveira
authors.affiliation: Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil.
authors.forename: Gláucia Maria
authors.initials: GM
authors.lastname: Cavasin
authors.affiliation: Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil.
authors.forename: Mara Rubia
authors.initials: MR
authors.lastname: Marques
authors.affiliation: São Paulo State University - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, 2265, São José do Rio Preto, São Paulo 15054000, Brazil.
authors.forename: Sebastião Roberto
authors.initials: SR
authors.lastname: Taboga
authors.affiliation: Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil. Electronic address: fernanda_alcantara@ufg.br.
authors.forename: Fernanda Cristina Alcantara
authors.initials: FC
authors.lastname: Santos
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001559:Benzhydryl Compounds / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D052244:Endocrine Disruptors / Q000633:toxicity*; D047628:Estrogen Receptor alpha / Q000378:metabolism; D005260:Female; D005849:Gerbillinae; D021621:Imaging, Three-Dimensional; D007150:Immunohistochemistry; D008297:Male; D010636:Phenols / Q000633:toxicity*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011467:Prostate / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D012737:Sex Factors; D000098826:Bisphenol A Compounds
chemical_list: D000199:Actins; D001559:Benzhydryl Compounds; D015415:Biomarkers; D052244:Endocrine Disruptors; D047628:Estrogen Receptor alpha; D010636:Phenols; D018809:Proliferating Cell Nuclear Antigen; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: AR antagonists; Endocrine-disrupting chemicals; Gerbil; Prostatic morphogenesis