title: Vaccination Against Dengue: Challenges and Current Developments.
abstract: Dengue is a growing threat worldwide, and the development of a vaccine is a public health priority. The completion of the active phase of two pivotal efficacy studies conducted in Asia and Latin America by Sanofi Pasteur has constituted an important step. Several other approaches are under development, and whichever technology is used, vaccine developers face several challenges linked to the particular nature and etiology of dengue disease. We start our review by defining questions and potential issues linked to dengue pathology and presenting the main types of vaccine approaches that have explored these questions; some of these candidates are in a late stage of clinical development. In the second part of the review, we focus on the Sanofi Pasteur dengue vaccine candidate, describing the steps from research to phase III efficacy studies. Finally, we discuss what could be the next steps, before and after vaccine introduction, to ensure that the vaccine will provide the best benefit with an acceptable safety profile to the identified target populations.
authors.affiliation: Research and Development, Sanofi Pasteur, 69007 Lyon, France; email: bruno.guy@sanofipasteur.com.
authors.forename: Bruno
authors.initials: B
authors.lastname: Guy
authors.affiliation: Research and Development, Sanofi Pasteur, 69007 Lyon, France; email: bruno.guy@sanofipasteur.com.
authors.forename: Jean
authors.initials: J
authors.lastname: Lang
authors.affiliation: Research and Development, Sanofi Pasteur, 69007 Lyon, France; email: bruno.guy@sanofipasteur.com.
authors.forename: Melanie
authors.initials: M
authors.lastname: Saville
authors.affiliation: Research and Development, Sanofi Pasteur, 69007 Lyon, France; email: bruno.guy@sanofipasteur.com.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Jackson
mesh_terms: D002986:Clinical Trials as Topic; D003715:Dengue / Q000276:immunology* / Q000517:prevention & control*; D053059:Dengue Vaccines / Q000009:adverse effects / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D055808:Drug Discovery; D006801:Humans; D018581:Technology Transfer; D014613:Vaccines, Attenuated
chemical_list: D053059:Dengue Vaccines; D014613:Vaccines, Attenuated
keywords: clinical trials; flavivirus; human; immunology; safety; vaccine