title: The role of CK2 protein kinase in stress response of RAW 264.7 macrophages.
abstract: The role of casein kinase 2 (CK2) in the activation of the key NF-κB signaling cascade and other signaling and stress proteins during stress induced by exposure to nonthermal low-intensity electromagnetic radiation has been investigated. The ability of CK2 to regulate the activation of the NF-κB signaling cascade and upregulate the proinflammatory cytokine production and TLR4 receptor expression has been demonstrated. The existence of an alternative signaling pathway for NF-κB cascade activation directly involving protein kinase CK2 has been demonstrated using inhibition analysis in cells stressed by microwave irradiation.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia. elenanov_06@mail.ru.
authors.forename: O V
authors.initials: OV
authors.lastname: Glushkova
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
authors.forename: M O
authors.initials: MO
authors.lastname: Khrenov
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Novoselova
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
authors.forename: S M
authors.initials: SM
authors.lastname: Lunin
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Fesenko
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Novoselova
mesh_terms: D000818:Animals; D047390:Casein Kinase II / Q000378:metabolism*; D002460:Cell Line; D004574:Electromagnetic Fields; D008264:Macrophages / Q000378:metabolism* / Q000528:radiation effects; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction; D013312:Stress, Physiological; D051197:Toll-Like Receptor 4 / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D051197:Toll-Like Receptor 4; D047390:Casein Kinase II