title: MTA1 Is Up-regulated in Colorectal Cancer and Is Inversely Correlated with Lymphatic Metastasis.
abstract: BACKGROUND
  Metastasis-associated protein 1 (MTA1) plays an important role in tumourigenesis and progression of certain cancer types. In the current study, we analyzed the relationship between MTA1 expression and disease progression of colorectal cancer (CRC).
  
  
  METHODS
  CRC tissues (n=93) and adjacent normal colorectal tissues (n=70) were analyzed by quantitative real-time polymerase chain reaction. MTA1 knockdown was established in RKO and HT115 cells using MTA1 siRNA.
  
  
  RESULTS
  The expression of MTA1 was significantly increased in CRC tissues compared to paired normal colorectal tissues, but decreased expression of MTA1 was correlated with poor prognosis (higher lymph node involvement stage, TNM stage, local invasion and recurrence) that was associated with increased expression of VEGFC and -D and the receptor VEGFR3.
  
  
  CONCLUSIONS
  MTA1 is up-regulated in CRC. MTA1 expression is inversely associated with lymphatic metastases and the expression of VEGFC, VEGFD and VEGFR3.
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K. Department of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: Ping-Hui
authors.initials: PH
authors.lastname: Sun
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: Lucy
authors.initials: L
authors.lastname: Satherley
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: Rachel
authors.initials: R
authors.lastname: Hargest
authors.affiliation: Department of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. China.
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K. Department of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. China Cardiff University-Capital Medical University Joint Centre for Biomedical Research & Cancer Institute, Capital Medical University, Beijing, P.R. China JiangW@cf.ac.uk.
authors.forename: Wen G
authors.initials: WG
authors.lastname: Jiang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D018938:Caco-2 Cells; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism*; D018450:Disease Progression; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D034741:RNA, Small Interfering / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D012097:Repressor Proteins / Q000378:metabolism*; D015534:Trans-Activators; D015854:Up-Regulation; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism; D042643:Vascular Endothelial Growth Factor D / Q000378:metabolism; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000378:metabolism; D014945:Wound Healing
chemical_list: D014408:Biomarkers, Tumor; C089320:MTA1 protein, human; D034741:RNA, Small Interfering; D012097:Repressor Proteins; D015534:Trans-Activators; C467486:VEGFC protein, human; C579459:VEGFD protein, human; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D; C581309:FLT4 protein, human; D040321:Vascular Endothelial Growth Factor Receptor-3; D006655:Histone Deacetylases
keywords: MTA1; VEGFC; colorectal carcinoma; lymphatic metastasis