title: IL-22: a promising candidate to inhibit viral-induced liver disease progression and hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is a growing concern all over the world. With the number of patients rising exponentially with each passing day, HCC is a problem that needs immediate attention. Currently, available treatment strategies focus on controlling the damage after the development of HCC. The options available from chemo- and radio-embolization to surgical resection and transplantation are not efficacious as required due to the complex nature of the disease. Liver regeneration and tissue healing are the subject of great interest today. Interleukin-22 (IL-22) is a cytokine with the ability to regenerate and therefore reverse the injuries caused by a wide range of agents. IL-22 acts via STAT molecule and controls the activity of a wide variety of cell survival and proliferation genes. Experimental data has given a positive insight into the role of IL-22 in inhibition of viral and alcohol-induced hepatocellular carcinoma. A further insight into the nature of IL-22 and the factors that can be manipulated in controlling the activity of IL-22 can help to counter the menace caused by the devastating effects of HCC.
authors.affiliation: Atta-ur-Rahman School of Applied Bio-Sciences, Department of Healthcare Biotechnology, National University of Sciences and Technology, Islamabad, 44000, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saalim
authors.affiliation: Atta-ur-Rahman School of Applied Bio-Sciences, Department of Healthcare Biotechnology, National University of Sciences and Technology, Islamabad, 44000, Pakistan.
authors.forename: Saleha
authors.initials: S
authors.lastname: Resham
authors.affiliation: Atta-ur-Rahman School of Applied Bio-Sciences, Department of Healthcare Biotechnology, National University of Sciences and Technology, Islamabad, 44000, Pakistan. lcianunique@yahoo.com.
authors.forename: Sobia
authors.initials: S
authors.lastname: Manzoor
authors.affiliation: Hepatopancreatobiliary Liver Transplant Unit, Shaikh Zayd Hospital, Lahore, 54000, Punjab, Pakistan.
authors.forename: Hassam
authors.initials: H
authors.lastname: Ahmad
authors.affiliation: Department of Histopathology, Shaikh Zayd Hospital, Lahore, 54000, Punjab, Pakistan.
authors.forename: Shahla
authors.initials: S
authors.lastname: Jaleel
authors.affiliation: Islam Dental College, Sialkot, 51310, Punjab, Pakistan.
authors.forename: Javed
authors.initials: J
authors.lastname: Ashraf
authors.affiliation: Atta-ur-Rahman School of Applied Bio-Sciences, Department of Healthcare Biotechnology, National University of Sciences and Technology, Islamabad, 44000, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Imran
authors.affiliation: Atta-ur-Rahman School of Applied Bio-Sciences, Department of Healthcare Biotechnology, National University of Sciences and Technology, Islamabad, 44000, Pakistan.
authors.forename: Sidrah
authors.initials: S
authors.lastname: Naseem
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000628:therapy / Q000821:virology; D049109:Cell Proliferation; D002470:Cell Survival; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D016174:Hepacivirus; D006515:Hepatitis B virus; D006801:Humans; D007249:Inflammation; D007378:Interleukins / Q000378:metabolism*; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis; D008113:Liver Neoplasms / Q000378:metabolism* / Q000628:therapy / Q000821:virology; D008115:Liver Regeneration; D008954:Models, Biological; D012038:Regeneration; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D000097043:Interleukin-22
chemical_list: D016207:Cytokines; D007378:Interleukins; D050796:STAT3 Transcription Factor; D000097043:Interleukin-22; C494086:STAT3 protein, human
keywords: Hepatocellular carcinoma; IL-22; Liver regeneration