title: NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans.
abstract: Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal. Statistical analysis of data extracted from the selected high quality studies was performed using the Version 12.0 STATA software. A total of 13 case-control studies met our stringent inclusion and exclusion criteria for the present meta-analysis. These 13 high quality studies contained relevant information on 7719 patients with various diseases and 7094 healthy controls. Our meta-analysis results showed that the NLRP3 gene rs35829419 C>A polymorphism was associated with a significantly increased risk of developing multiple diseases in humans under 5 genetic models (all P < 0.05). Data stratification and subgroup analysis based on the disease type revealed that rs35829419 C>A carriers displayed a markedly increase susceptibility to leprosy, colorectal cancer, HIV-1 infection, rheumatoid arthritis, abdominal aortic aneurysms, inflammatory bowel disease, ulcerative colitis, and atopic dermatitis. In summary, our meta-analysis results revealed the first identified strong correlation between the NLRP3 rs35829419 polymorphism and increased susceptibility to various diseases in humans.
authors.affiliation: Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: H W
authors.initials: HW
authors.lastname: Fan
authors.affiliation: Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, China Japan Union Hospital of Jilin University, Changchun, China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Xing
mesh_terms: D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: D002352:Carrier Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human