title: Natural Conception May Be an Acceptable Option in HIV-Serodiscordant Couples in Resource Limited Settings.
abstract: Many HIV serodiscordant couples have a strong desire to have their own biological children. Natural conception may be the only choice in some resource limited settings but data about natural conception is limited. Here, we reported our findings of natural conception in HIV serodiscordant couples. Between January 2008 and June 2014, we retrospectively collected data on 91 HIV serodiscordant couples presenting to Beijing Youan Hospital with childbearing desires. HIV counseling, effective ART on HIV infected partners, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) in negative female partners and timed intercourse were used to maximally reduce the risk of HIV transmission. Of the 91 HIV serodiscordant couples, 43 were positive in male partners and 48 were positive in female partners. There were 196 unprotected vaginal intercourses, 100 natural conception and 97 newborns. There were no cases of HIV seroconversion in uninfected sexual partners. Natural conception may be an acceptable option in HIV-serodiscordant couples in resource limited settings if HIV-positive individuals have undetectable viremia on HAART, combined with HIV counseling, PrEP, PEP and timed intercourse.
authors.affiliation: Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Sun
authors.affiliation: National Center for Women and Children's Health, China CDC, Beijing, 100081, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
authors.forename: An
authors.initials: A
authors.lastname: Liu
authors.affiliation: Beijing Center for Preventive Medicine Research, Beijing, 100013, China.
authors.forename: Ruolei
authors.initials: R
authors.lastname: Xin
authors.affiliation: Department of Gynecology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Li
authors.affiliation: Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
authors.forename: Jiangzhu
authors.initials: J
authors.lastname: Ye
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang Province, China.
authors.forename: Danqing
authors.initials: D
authors.lastname: Chen
authors.affiliation: Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
authors.forename: Zaicun
authors.initials: Z
authors.lastname: Li
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D000068476:Beijing; D003376:Counseling / Q000379:methods; D005191:Family Characteristics; D005260:Female; D005306:Fertilization / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology*; D006679:HIV Seropositivity / Q000188:drug therapy / Q000503:physiopathology*; D006295:Health Resources; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008297:Male; D056990:Post-Exposure Prophylaxis / Q000379:methods; D065129:Pre-Exposure Prophylaxis / Q000379:methods; D012189:Retrospective Studies; D012747:Sexual Partners
chemical_list: D019380:Anti-HIV Agents