title: Locoregional treatment for hepatocellular carcinoma: The best is yet to come.
abstract: Hepatocellular carcinoma (HCC) is the sixth-most common type of cancer worldwide. The only definitive treatment modalities capable of achieving a cure are hepatic resection and hepatic transplantation. However, most patients are not candidates for these therapies. Overall, treatment options are driven by the stage of HCC. Early-stage disease is treated with ablative therapies, with radiofrequency ablation the ablative therapy of choice. Microwave ablation and irreversible electroporation are the other upcoming alternatives. Intermediate-stage disease is managed with transarterial chemoembolization (TACE), while advanced-stage disease is managed by sorafenib, with TACE and radioembolization as other alternatives.
authors.affiliation: Naveen Kalra, Pankaj Gupta, Niranjan Khandelwal, Deparment of Radiodiagnosis and Imaging, PGIMER, Chandigarh 160012, India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Kalra
authors.affiliation: Naveen Kalra, Pankaj Gupta, Niranjan Khandelwal, Deparment of Radiodiagnosis and Imaging, PGIMER, Chandigarh 160012, India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Gupta
authors.affiliation: Naveen Kalra, Pankaj Gupta, Niranjan Khandelwal, Deparment of Radiodiagnosis and Imaging, PGIMER, Chandigarh 160012, India.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Chawla
authors.affiliation: Naveen Kalra, Pankaj Gupta, Niranjan Khandelwal, Deparment of Radiodiagnosis and Imaging, PGIMER, Chandigarh 160012, India.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Khandelwal
keywords: Hepatocellular carcinoma; High intensity focussed ultrasound; Irreversible electroporation; Microwave ablation; Radiofrequency ablation