title: Perspectives in Intraoperative Diagnostics of Human Gliomas.
abstract: Amongst large a variety of oncological diseases, malignant gliomas represent one of the most severe types of tumors. They are also the most common type of the brain tumors and account for over half of the astrocytic tumors. According to different sources, the average life expectancy of patients with various glioblastomas varies between 10 and 12 months and that of patients with anaplastic astrocytic tumors between 20 and 24 months. Therefore, studies of the physiology of transformed glial cells are critical for the development of treatment methods. Modern medical approaches offer complex procedures, including the microsurgical tumor removal, radiotherapy, and chemotherapy, supplemented with photodynamic therapy and immunotherapy. The most radical of them is surgical resection, which allows removing the largest part of the tumor, reduces the intracranial hypertension, and minimizes the degree of neurological deficit. However, complete removal of the tumor remains impossible. The main limitations are insufficient visualization of glioma boundaries, due to its infiltrative growth, and the necessity to preserve healthy tissue. This review is devoted to the description of advantages and disadvantages of modern intraoperative diagnostics of human gliomas and highlights potential perspectives for development of their treatment.
authors.affiliation: Lobachevsky State University of Nizhni Novgorod, Institute of Biology and Biomedicine, Russia.
authors.forename: O
authors.initials: O
authors.lastname: Tyurikova
authors.affiliation: Lobachevsky State University of Nizhni Novgorod, Institute of Biology and Biomedicine, Russia.
authors.forename: Y
authors.initials: Y
authors.lastname: Dembitskaya
authors.affiliation: Federal State Budgetary Institution, "Privolzhsky Federal Research Medical Centre" of the Ministry of Health of the Russian Federation, Russia.
authors.forename: K
authors.initials: K
authors.lastname: Yashin
authors.affiliation: Lobachevsky State University of Nizhni Novgorod, Institute of Biology and Biomedicine, Russia.
authors.forename: M
authors.initials: M
authors.lastname: Mishchenko
authors.affiliation: Lobachevsky State University of Nizhni Novgorod, Institute of Biology and Biomedicine, Russia ; Nizhny Novgorod State Medical Academy, Russia.
authors.forename: M
authors.initials: M
authors.lastname: Vedunova
authors.affiliation: Federal State Budgetary Institution, "Privolzhsky Federal Research Medical Centre" of the Ministry of Health of the Russian Federation, Russia.
authors.forename: I
authors.initials: I
authors.lastname: Medyanik
authors.affiliation: Lobachevsky State University of Nizhni Novgorod, Institute of Biology and Biomedicine, Russia.
authors.forename: V
authors.initials: V
authors.lastname: Kazantsev
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery*; D002465:Cell Movement; D019295:Computational Biology; D005910:Glioma / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D061705:Image-Guided Biopsy; D007432:Intraoperative Period; D008279:Magnetic Resonance Imaging; D061848:Optical Imaging; D025321:Surgery, Computer-Assisted; D014463:Ultrasonography
chemical_list: D018698:Glutamic Acid