title: Angiosuppressive properties of marine-derived compounds-a mini review.
abstract: Angiogenesis, formation of new blood vessels from preexisting one, is a critical step of tumorgenesis of solid tumors. Therefore, antiangiogenic therapy is one of the promising approaches to control tumor growth. In the past 20 years, a lot of compounds have been tested for their antiangiogenic properties. Bevacizumab, Avastin®, the first antiangiogenic drug approved by the US FDA, has been widely used in clinic for treating cancer. Indeed, many synthetic compounds are highly toxic and exert side effects even though they are effective in inhibiting neovessel formation and cancer cell growth. Using natural compounds or their derivatives is one of the ways to solve these problems. Sinomenine and ginsenosides are common antiangiogenic and anticancer compounds that are extracted from herbal medicines. Recent findings suggested that marine algae-derived natural pigments also possess similar activities. It has been reported that fucoxanthin from Undaria pinnatifida, Siphonaxanthin from Codium fragile, can inhibit angiogenesis and cancer growth effectively. In conclusion, natural compounds derived from marine algae could provide a novel and safe source for new drug development in anticancer and antiangiogenic properties in the future.
authors.affiliation: Department of Biology, Faculty of Science, Hong Kong Baptist University, HKSAR, Kowloon Tong, Hong Kong. patrick@hkbu.edu.hk.
authors.forename: Patrick Y K
authors.initials: PY
authors.lastname: Yue
authors.affiliation: Department of Biology, Faculty of Science, Hong Kong Baptist University, HKSAR, Kowloon Tong, Hong Kong.
authors.forename: H M
authors.initials: HM
authors.lastname: Leung
authors.affiliation: Department of Chemistry, Faculty of Science, Hong Kong Baptist University, HKSAR, Kowloon Tong, Hong Kong.
authors.forename: Adela J
authors.initials: AJ
authors.lastname: Li
authors.affiliation: Department of Biology, Faculty of Science, Hong Kong Baptist University, HKSAR, Kowloon Tong, Hong Kong.
authors.forename: Tracy N C
authors.initials: TN
authors.lastname: Chan
authors.affiliation: Department of Chemistry, Faculty of Science, Hong Kong Baptist University, HKSAR, Kowloon Tong, Hong Kong.
authors.forename: T S
authors.initials: TS
authors.lastname: Lum
authors.affiliation: Department of Biology, Faculty of Science, Hong Kong Baptist University, HKSAR, Kowloon Tong, Hong Kong.
authors.forename: Y L
authors.initials: YL
authors.lastname: Chung
authors.affiliation: Department of Biology, Faculty of Science, Hong Kong Baptist University, HKSAR, Kowloon Tong, Hong Kong.
authors.forename: Y H
authors.initials: YH
authors.lastname: Sung
authors.affiliation: Department of Science and Environmental Studies, Hong Kong Institute of Education, HKSAR, Kowloon Tong, Hong Kong.
authors.forename: M H
authors.initials: MH
authors.lastname: Wong
authors.affiliation: Department of Chemistry, Faculty of Science, Hong Kong Baptist University, HKSAR, Kowloon Tong, Hong Kong.
authors.forename: Kelvin S Y
authors.initials: KS
authors.lastname: Leung
authors.affiliation: School of Environment and Guangzhou Key Laboratory of Environmental Exposure and Health, Jinan University, Guangzhou, China.
authors.forename: Eddy Y
authors.initials: EY
authors.lastname: Zeng
mesh_terms: D020533:Angiogenesis Inhibitors; D006801:Humans; D009369:Neoplasms; D009389:Neovascularization, Pathologic
chemical_list: D020533:Angiogenesis Inhibitors
keywords: Angiogenesis; Angiosuppression; Marine-derived compound