title: Predictors of Symptom Development in Intermediate Carotid Artery Stenosis: Mean Platelet Volume and Platelet Distribution Width.
abstract: Platelets play an important role in the pathogenesis of atherothrombosis. Platelet activation is associated with increased mean platelet volume (MPV) and platelet distribution width (PDW). In this study, we investigated the relation of MPV and PDW with the risk of stroke in patients with intermediate (50%-70%) carotid artery stenosis. A total of 254 patients (115 symptomatic and 139 asymptomatic) with intermediate carotid artery stenosis were enrolled in this study. Symptomatic and asymptomatic patients were compared in regard to MPV and PDW. Mean platelet volume was significantly greater in the symptomatic group compared with the asymptomatic group (11.1 and 9.4 fL, respectively; P < .001). Platelet distribution width was significantly greater in the symptomatic group compared with the asymptomatic group (15.0% and 11.9%, respectively; P < .001). Multivariate regression analysis showed that an MPV ≥10.2 fL and a PDW ≥14.3% were independent predictors of developing symptomatic carotid artery stenosis. Mean platelet volume and PDW are increased in the presence of symptomatic intermediate carotid artery stenosis. Increased MPV and PDW may be independent predictors of developing symptomatic carotid artery plaque.
authors.affiliation: Cardiology Clinic, Antalya Training and Research Hospital, Antalya, Turkey drerkankoklu@gmail.com.
authors.forename: Erkan
authors.initials: E
authors.lastname: Koklu
authors.affiliation: Cardiology Clinic, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Isa Oner
authors.initials: IO
authors.lastname: Yuksel
authors.affiliation: Cardiology Clinic, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Sakir
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Cardiology Clinic, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Goksel
authors.initials: G
authors.lastname: Cagirci
authors.affiliation: Neurology Clinic, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Elif Sarionder
authors.initials: ES
authors.lastname: Gencer
authors.affiliation: Radiology Clinic, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Koc
authors.affiliation: Cardiology Clinic, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Cay
authors.affiliation: Department of Cardiology, Medipol University Faculty of Medicine, Istanbul, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Kizilirmak
authors.affiliation: Cardiology Clinic, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Esin
mesh_terms: D000368:Aged; D019540:Area Under Curve; D058070:Asymptomatic Diseases; D001792:Blood Platelets; D016893:Carotid Stenosis / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D016009:Chi-Square Distribution; D000072226:Computed Tomography Angiography; D018450:Disease Progression; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D018608:Ultrasonography, Doppler
keywords: carotid artery stenosis; mean platelet volume; platelet distribution width; stroke