title: Association of the GSTM1 null polymorphism with breast cancer in a Mexican population.
abstract: The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion in the mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotypes of 276 healthy Mexican women with those of 558 Mexican women with breast cancer (BC). The genotype frequencies observed in the controls and patients with BC were 38 and 45% for the null GSTM1 genotype, respectively. The obtained odds ratio (OR) was 1.36, with a 95% confidence interval (95%CI) of 1.02-1.8, P = 0.04. The protective association was also evident upon analysis of the distributions of the null GSTM1 genotype in patients with positive chemotherapy response who had high plasma levels of glucose (OR 0.56, 95%CI = 0.33-0.94, P = 0.03). This study suggested that the null GSTM1 genotype is associated with BC susceptibility in the Mexican population analyzed.
authors.affiliation: Molecular Genetics Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: O
authors.initials: O
authors.lastname: Soto-Quintana
authors.affiliation: Mutagenesis Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: G M
authors.initials: GM
authors.lastname: Zúñiga-González
authors.affiliation: Molecular Genetics Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Ramírez-Patiño
authors.affiliation: Molecular Genetics Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Ramos-Silva
authors.affiliation: Genetics Division, Western Biomedical Research Center, Western National Medical Center, Guadalajara, Jalisco, México.
authors.forename: L E
authors.initials: LE
authors.lastname: Figuera
authors.affiliation: Molecular Genetics Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: D I
authors.initials: DI
authors.lastname: Carrillo-Moreno
authors.affiliation: Molecular Genetics Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: I A
authors.initials: IA
authors.lastname: Gutiérrez-Hurtado
authors.affiliation: Immunopharmacology Laboratory, Exact Science and Engineer University Center, University of Guadalajara, Guadalajara, Jalisco, México.
authors.forename: A M
authors.initials: AM
authors.lastname: Puebla-Pérez
authors.affiliation: Highly Specialized Medical Unit of Gynecology-Obstetrics Hospital, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
authors.forename: B
authors.initials: B
authors.lastname: Sánchez-Llamas
authors.affiliation: Molecular Genetics Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico marthapatriciagallegos08@gmail.com.
authors.forename: M P
authors.initials: MP
authors.lastname: Gallegos-Arreola
mesh_terms: D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D012307:Risk Factors
chemical_list: D005982:Glutathione Transferase