title: Proteomic Profiling of Serum-Derived Exosomes from Ethnically Diverse Prostate Cancer Patients.
abstract: Prostate cancer (PCa) remains the most frequently diagnosed male malignancy in Western countries and the second most common cause of male cancer death in the United States. The relatively elevated PCa incidence and mortality among African American men makes this cancer type a challenging health disparity disease. To increase the chance for successful trea tment, earlier detection and prediction of tumor aggress iveness will be important and need to be resolved. This study demonstrates that small membrane-bound vesicles shed from the tumor called exosomes contain ethnically and tumor-specific biomarkers, and could be exploited for their diagnostic and therapeutic potential.
authors.affiliation: a Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.|b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
authors.forename: David
authors.initials: D
authors.lastname: Turay
authors.affiliation: a Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.|b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
authors.forename: Salma
authors.initials: S
authors.lastname: Khan
authors.affiliation: a Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.|b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Diaz Osterman
authors.affiliation: b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Curtis
authors.affiliation: b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
authors.forename: Balreet
authors.initials: B
authors.lastname: Khaira
authors.affiliation: b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Neidigh
authors.affiliation: c Department of Basic Science and Division of Microbiology and Molecular Genetics , Loma Linda University School of Medicine , Loma Linda , California , USA.|d Cancer Center & Biospecimen Laboratory , Loma Linda University School of Medicine , Loma Linda , California , USA.
authors.forename: Saied
authors.initials: S
authors.lastname: Mirshahidi
authors.affiliation: a Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.|c Department of Basic Science and Division of Microbiology and Molecular Genetics , Loma Linda University School of Medicine , Loma Linda , California , USA.|e Department of Medicine, Division of Rheumatology , Loma Linda University School of Medicine , Loma Linda , California , USA.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Casiano
authors.affiliation: a Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.|b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Wall
mesh_terms: D014408:Biomarkers, Tumor; D016022:Case-Control Studies; D019295:Computational Biology; D005006:Ethnicity; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000097:blood / Q000378:metabolism*; D020543:Proteome; D040901:Proteomics / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D020543:Proteome
keywords: Biomarker; Early detection; Exosome; Health disparity; Prostate cancer; Proteome