title: [The use of hybrid revascularization procedures for the therapy of multilevel lower extremity arterial disease--analysis of single center experience].
abstract: BACKGROUND
  The goal of this study was to evaluate our experience and results of single staged hybrid procedures for revascularization of lower extremities affected by multilevel arterial occlusive disease. We analysed the effect of the indication and type of reconstruction on patency.
  
  
  METHODS
  Patients were retrospectively reviewed. Data collection was conducted prospectively. Patients were divided into 5 groups based on the type of hybrid reconstruction. Group "1" included patients who underwent transluminal angioplasty (TA)±stenting of iliac arteries with endarterectomy (EA) and patch arterioplasty of the femoral bifurcation (35 patients; 27.6 %). Group "2" included patients who underwent TA±stenting of iliac arteries with infrainguinal bypass (15 patients; 11.8 %). Group "3" consisted of patients who underwent TA±stenting of outflow lower extremity arteries: superficial femoral artery±popliteal artery±crural arteries in combination with EA and patch arterioplasty of the femoral bifurcation (52 patients; 40.9 %). Group "4" represented patients who underwent infrainguinal bypass surgery in combination with TA distal to the site of open reconstruction (3 patients; 2.4%). Group "5" represented a heterogenous population of patients who underwent a hybrid reconstruction which did not belong to any of the 4 previously mentioned groups (22 patients; 17.3 %). The patients were divided into 3 groups based on the indication criteria of the intervention: Patients with acute limb ischemia (ALI) were put into group "ALI". Patients with critical limb ischemia (CLI) were put into group "CLI". Patients with claudications were put into group "II". Patency analyses were performed using Kaplan-Meier life tables. Differences in patency rates between the different groups of patients were determined using the log-rank test. Statistical analysis was performed using the software IBM SPSS Statistics 21.0.
  
  
  RESULTS
  The study included 127 patients who underwent 127 hybrid arterial procedures. Technical and clinical success rates were 96.9% and 98.4%. 30-day perioperative mortality rate was 3.1%. The primary (PP), assisted-primary (APP) and secondary patency (SP) results at 2 years were the best amongst the patients from groups "1" and "3". These patients underwent patch arterioplasty±EA of the femoral bifurcation in combination with transluminal angioplasty of inflow or outflow arteries of the lower extremity. The resulting PP, APP and SP rates at 2 years in group "1" were 80.6%, 84.3% and 84.3%. Patency rates in group "3" in the same order at 2 years were 81.1 %, 82.8% and 86.3%. Significantly lower patency rates were achieved in patients from groups "2" and "5". The resulting PP, APP and SP rates in group "2" at 2 years were 39.4%, 59.1% and 59.1%; in group "5" at 2 years they were 30.4%, 49.2% and 70.7%. Taking into account the effect of the indication on patency rates, we found that patients from group "CLI" had the best APP and SP rates at 2 years: 81.6% and 86.2%. Only the PP rate at 2 years was the best in group "II" (patients with claudications): 71.1%. Patients who underwent their operations because of acute limb ischemia (group "ALI") achieved the worst results among these 3 groups. Their PP, APP and SP rates at 2 years were 33.7%, 46.2% and 45.5%. Patients from the group "CLI" had the best amputation-free survival at 2 years: 89.1% amongst the 3 groups subdivided according to the indication for the intervention ("II" 81.9%; "ALI" 61.4%). Overall survival and amputation-free survival at 2 years were 93.2% and 82.3%, respectively, for the whole studied population.
  
  
  CONCLUSIONS
  The hybrid procedure is an intervention which combines endovascular and open reconstruction performed at the same time. Hybrid procedures provide effective therapy for patients with multilevel lower extremity arterial disease. They have low complication rates, periprocedural morbidity and mortality. Using these procedures, we are able to achieve good limb salvage rates and patency rates irrespective of the form of chronic limb ischemia (claudications, critical limb ischemia). Results for patients with acute limb ischemia are inferior. The combination of patch arterioplasty±endarterectomy of the femoral bifurcation with transluminal angioplasty of inflow or outflow limb arteries is our hybrid procedure of choice with the most favourable results.
authors.forename: E
authors.initials: E
authors.lastname: Biroš
authors.forename: R
authors.initials: R
authors.lastname: Staffa
authors.forename: R
authors.initials: R
authors.lastname: Vlachovský
authors.forename: M
authors.initials: M
authors.lastname: Trnová-Chudárková
authors.forename: B
authors.initials: B
authors.lastname: Vojtíšek
authors.forename: I
authors.initials: I
authors.lastname: Suškevič
authors.forename: E
authors.initials: E
authors.lastname: Janoušová
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000628:therapy*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000628:therapy; D035002:Lower Extremity / Q000098:blood supply* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015607:Stents; D014654:Vascular Patency; D014656:Vascular Surgical Procedures