title: [Development of Targets for Anti-influenza Virus Based on Nucleoprotein].
abstract: The influenza A is an acute respiratory infection persistently threatening human health and social stability, and has caused high morbidity and mortality. The development of novel anti-influenza drugs based on new targets is very significant because of high mutation and drug resistance of influenza virus. The nucleoprotein of influenza A virus identified high conservation, provides cross immune protection as a potential target of anti-influenza drugs and reports on relevant studies have been published at home and a- board. Herbal drug as a traditional Chinese medicine shows the distinct advantages in the aspect of prevention and treatment of influenza A. This paper analyzes the structure and function of influenza a virus, and reviews the advances in the research on anti-influenza targets based on the nucleoprotein of the influenza A virus.
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology; D007251:Influenza, Human / Q000188:drug therapy; D058990:Molecular Targeted Therapy / Q000379:methods*; D009698:Nucleoproteins / Q000737:chemistry / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D009698:Nucleoproteins