title: Effect of Selective Blockade of α2C-Adrenoceptors on Cardiac Activity in Growing Rats.
abstract: Selective blockade of α2C-adrenoceptors had different effects on the cardiovascular system in rats of various age groups. Blockade of α2C-adrenoceptors in adult rats and 3-week-old animals produced the positive and negative chronotropic effects, respectively. HR in 1-week-old and 6-week-old rats did not change during α2C-adrenoceptor blockade. Selective blockade of α2C-adrenoceptors in adult rats and 3-week-old animals was followed by the increase in BP. BP in 6-week-old rats was shown to decrease under these conditions.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan State Medical University, Kazan, Republic of Tatarstan, Russia. zefirovtl@mail.ru.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan State Medical University, Kazan, Republic of Tatarstan, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Khisamieva
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan State Medical University, Kazan, Republic of Tatarstan, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Ziyatdinova
authors.affiliation: Department of Normal Physiology, Kazan State Medical University, Kazan, Republic of Tatarstan, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D021461:Animals, Outbred Strains; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism; D048788:Growth and Development / Q000187:drug effects*; D006321:Heart / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism / Q000502:physiology
chemical_list: D058669:Adrenergic alpha-2 Receptor Antagonists; D018341:Receptors, Adrenergic, alpha-2
keywords: cardiovascular system; chronotropism; rat; α-adrenoceptors