title: An Individual-Centered Framework For Unravelling Genotype-Phenotype Interactions.
abstract: A new framework in which the multiple levels of molecular variations contribute to phenotypic variations in a complex, nonlinear and interactive way, challenges the hierarchical nature of the relationships between the genotypic and phenotypic spaces. This individual-centered framework provides new insights on the evolutionary mechanisms involved in the production of phenotypes. We propose to move this research agenda forward by combining selection experiments and functional genetics.
authors.affiliation: Station d'Ecologie Expérimentale, CNRS USR 2936, F-09200 Moulis, France; Muséum National d'Histoire Naturelle, UMR 7205 ISYEB, F-75005, Paris, France. Electronic address: baguette@mnhn.fr.
authors.forename: Michel
authors.initials: M
authors.lastname: Baguette
authors.affiliation: Station d'Ecologie Expérimentale, CNRS USR 2936, F-09200 Moulis, France; Earth and Life Institute, UCL BRC, B-1348, Louvain-la-Neuve, Belgium.
authors.forename: Delphine
authors.initials: D
authors.lastname: Legrand
authors.affiliation: Station d'Ecologie Expérimentale, CNRS USR 2936, F-09200 Moulis, France.
authors.forename: Virginie M
authors.initials: VM
authors.lastname: Stevens
mesh_terms: D003627:Data Interpretation, Statistical; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D040582:Inheritance Patterns / Q000502:physiology*; D008954:Models, Biological; D010641:Phenotype; D049490:Systems Biology / Q000379:methods*
keywords: Genome; epigenome; molecular pedigree of evolutionary changes; phenome; proteome; syndrome