title: One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere.
abstract: A facile one-pot synthesis of N-(α-peroxy)indole and N-(α-peroxy)carbazole has been developed using metal-free, organo-acid-catalyzed three-component condensation reactions of indole/carbazole, aldehyde, and peroxide. Based on the reaction discovered, a new synthetic proposal for Fumitremorgin A and Verruculogen is introduced. Such a protocol could be easily handled and scaled up in an open atmosphere with a wide substrate scope, enabling the construction of a new molecule library.
authors.affiliation: Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST) , Thuwal, 23955-6900, Kingdom of Saudi Arabia.|Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University , Shenzhen 518055, China.
authors.forename: Xinbo
authors.initials: X
authors.lastname: Wang
authors.affiliation: Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST) , Thuwal, 23955-6900, Kingdom of Saudi Arabia.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST) , Thuwal, 23955-6900, Kingdom of Saudi Arabia.
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Huang
authors.affiliation: Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST) , Thuwal, 23955-6900, Kingdom of Saudi Arabia.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Lai