title: [EFFICIENCY OF HAEMOGLOBIN REGENERATION IN THE NUTRITIONAL FERROPENIC ANAEMIA RECOVERY WITH GOAT MILK-BASED DIETS].
abstract: OBJECTIVE
  in spite of the high incidence/prevalence of iron deficiency anemia (IDA) and the beneficial effects derived from the consumption of goat milk, scarce is known about the recovery of the anemia following a balanced diet accompanied by the intake of goat milk of goat. The aim of the current study is to assess, in rats with experimentally induced nutritional iron deficiency anemia, the effects of goat or cow milk-based diets, supplied during 30 days, on the recovery of the anemia and the efficiency of regeneration of the hemoglobin.
  
  
  METHODS
  40 male Wistar albino rats newly weaned were divided at random in two experimental groups and they were fed ad libitum for 40 days with AIN-93G diet, either with normal iron content (control group, 45 mg/kg diet), or low iron content (anaemic group, 5 mg/kg diet). Samples of blood form the caudal vein were collected for the hematologic control of the anemia. Later, both experimental groups (control and iron deficient) were fed for 30 days with goat or cow milk- based diets. After finishing the experimental period and previous anesthesia the animals were withdrawn by canulation of the abdominal aorta, and the obtained blood was gathered in tubes with EDTA as anticoagulant for the later determination of hematologic parameters and the efficiency of regeneration of the hemoglobin.
  
  
  CONCLUSIONS
  after the consumption of a diet with low iron content during 40 days, the rats were anaemic, with a concentration of hemoglobin, hematocrit, serum iron, mean corpuscular volume (MCV), serum ferritin and low transferrin (p < 0.001), whereas the levels of platelets and the total iron binding capacity (TIBC) were raised (p < 0.001), findings consistent with the anemia induced experimentally in the animals. The efficiency of regeneration of the hemoglobin was higher in control and anaemic rats fed goat milk-based diet in comparison with those fed cow milk-based diet (p < 0.001) due to, partly, to the major levels of serum iron and hemoglobin, and to the best nutritive utilization of iron in the animals that consumed the goat milk-based diet thanks to the excellent nutritional characteristics of this type of milk.
  
  
  CONCLUSIONS
  the consumption during 30 days of goat or cow milk-based diets favors the recovery of the iron deficiency anemia, especially with the goat milk, due to the major efficiency of regeneration of the hemoglobin, index that shows the quantity of iron of the diet used for the synthesis of hemoglobin. Therefore, it would be recommendable the consumption of goat milk in the context of a balanced diet in healthy populations and, especially in those at risk of suffering iron deficiency.
authors.affiliation: Departamento de Fisiología, Facultad de Farmacia e Instituto de Nutrición y Tecnología de los Alimentos "José Mataix", Universidad de Granada, España.. milopez@ugr.es.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Serrano Reina
authors.affiliation: Departamento de Fisiología, Facultad de Farmacia e Instituto de Nutrición y Tecnología de los Alimentos "José Mataix", Universidad de Granada, España.. milopez@ugr.es.
authors.forename: Teresa
authors.initials: T
authors.lastname: Nestares Pleguezuelo
authors.affiliation: Departamento de Fisiología, Facultad de Farmacia e Instituto de Nutrición y Tecnología de los Alimentos "José Mataix", Universidad de Granada, España.. milopez@ugr.es.
authors.forename: Ma José
authors.initials: MJ
authors.lastname: Muñoz Alférez
authors.affiliation: Departamento de Fisiología, Facultad de Farmacia e Instituto de Nutrición y Tecnología de los Alimentos "José Mataix", Universidad de Granada, España.. milopez@ugr.es.
authors.forename: Javier
authors.initials: J
authors.lastname: Díaz Castro
authors.affiliation: Departamento de Fisiología, Facultad de Farmacia e Instituto de Nutrición y Tecnología de los Alimentos "José Mataix", Universidad de Granada, España.. milopez@ugr.es.
authors.forename: Ma Inmaculada
authors.initials: MI
authors.lastname: López Aliaga
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000178:diet therapy* / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D004032:Diet; D006041:Goats; D006454:Hemoglobins / Q000096:biosynthesis*; D008297:Male; D008892:Milk; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006454:Hemoglobins