title: Diagnostic Significance of Reduced IgA in Children.
abstract: BACKGROUND
  The finding of reduced value of immunoglobulin A (IgA) in children is frequent in daily medical practice. It is important to correctly interpret the findings as adequate further diagnostic evaluation of the patient in order to make the determination on the significance of such findings. In children younger than 4 years always consider the transient impairment of immunoglobulins, maturation of child and his immune system can lead to an improvement in the clinical picture. In older children decreased IgA may lead to serious illnesses that need to be recognize and acknowledge through the appropriate diagnostic methods. At the University Clinical Center Tuzla, children with suspected deficient immune response due to reduced values of IgA, goes through further diagnostic evaluation at the Polyclinic for Laboratory Medicine, Department of Immunology and Department of Microbiology, as well as the Clinic of Radiology.
  
  
  METHODS
  Our study followed 91 patients, for the year 2013, through their medical charts and made evaluation of diagnostic and screening tests.
  
  
  CONCLUSIONS
  The significance of this paper is to draw attention to the importance of diagnostic approach to IgA deficient pediatric patient and relevance of knowledge of individual diagnostic methods as well as to the proper interpretation of the results thereof.
authors.affiliation: Policlinic for laboratory diagnostic. University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Nurkic
authors.affiliation: Policlinic for laboratory diagnostic. University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Fatima
authors.initials: F
authors.lastname: Numanovic
authors.affiliation: Clinic for Radiology. University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Lejla
authors.initials: L
authors.lastname: Arnautalic
authors.affiliation: Policlinic for laboratory diagnostic. University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Nijaz
authors.initials: N
authors.lastname: Tihic
authors.affiliation: Clinic for Pulmonary Disease. University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Dzenan
authors.initials: D
authors.lastname: Halilovic
authors.affiliation: Policlinic for laboratory diagnostic. University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Mahira
authors.initials: M
authors.lastname: Jahic
mesh_terms: D000367:Age Factors; D017522:Bosnia and Herzegovina; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000175:diagnosis*; D007070:Immunoglobulin A / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D012016:Reference Values; D012737:Sex Factors
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E
keywords: IgA deficiency; children; diagnostic evaluation