title: [Relation of MBL ExonI 54 and NFκB1-94ins/del ATTG Polymorphism with Fever during Neutropenia in Patients with Acute Leukaemia after Chemotherapy].
abstract: OBJECTIVE
  To explore the correlation between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia (AL) (except M3) after first chemotherapy in Chinese Han population.
  
  
  METHODS
  Blood samples obtained from 76 fever patients with AL during neutropenia episodes were detected to analyse single nucleotide polymorphism (SNP) in the MBL ExonI 54 and NFκB1-94ins/del ATTG gene, and analyse the correlation between above-mentioned 2 polymorphisms and fever during neutropenia of AL patients after chemotherapy.
  
  
  RESULTS
  In 76 patients, no correlation were found between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia after chemotherapy (P > 0.05). No significant relation were found in sex, age, underlying disease, disease status or degrees of neutropenia in febrile neutropenia between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism (P > 0.05). However, patients with MBL ExonI 54 mutation presented longer febrile duration with a median of 5 days compared to 3 days of patients with wildtype MBL ExonI 54 genotype (P < 0.05).
  
  
  CONCLUSIONS
  There is no clear correlation between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia after chemotherapy. However, the patients with MBL ExonI 54 mutation have been observed to present a longer febrile duration.
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.|Department of Hematology, The First People Hospital of Foshan Municipality, Guangdong Province, Foshan 528000, China.
authors.forename: Wen-Ning
authors.initials: WN
authors.lastname: Xu
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
authors.forename: Zu-Jun
authors.initials: ZJ
authors.lastname: Jiang
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
authors.forename: Hao-Wen
authors.initials: HW
authors.lastname: Xiao
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Pang
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ouyang
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
authors.forename: Zeng-Hui
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
authors.forename: Le-Qing
authors.initials: LQ
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China. E-mail: jdxiao111@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000208:Acute Disease; D005091:Exons; D005334:Fever; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics*; D037601:Mannose-Binding Lectin / Q000235:genetics*; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D009503:Neutropenia; D020641:Polymorphism, Single Nucleotide
chemical_list: D037601:Mannose-Binding Lectin; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human