title: Successful use of pregabalin by the rectal route to treat chronic neuropathic pain in a patient with complete intestinal failure.
abstract: Pregabalin is widely used for treatment of neuropathic pain and is only approved for oral use. This is the first reported case of using pregabalin by the rectal route for treatment in a 70-year-old patient with chronic neuropathic pain and complete intestinal failure. Therapies used in an attempt to manage his chronic pain have included a variety of doses and strengths of opioid preparations and cannabinoids, plus topical and alternative therapies. These were not effective, so it was decided to start a trial of pregabalin administered by the rectal route. Serum levels were measured to assess absorption. Within a few weeks of starting the treatment, the patient had improved pain control and appeared more comfortable and calm.
authors.affiliation: University of Manchester, Manchester, UK.
authors.forename: Charlotte
authors.identifier: http://orcid.org/0000-0003-0721-2885
authors.initials: C
authors.lastname: Doddrell
authors.affiliation: Department of Anaesthetics, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.
authors.forename: Shiva Shankar
authors.initials: SS
authors.lastname: Tripathi
mesh_terms: D000285:Administration, Rectal; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D002186:Cannabinoids / Q000627:therapeutic use; D005283:Fentanyl / Q000627:therapeutic use; D006801:Humans; D007415:Intestinal Obstruction / Q000503:physiopathology*; D008297:Male; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology; D000069583:Pregabalin / Q000008:administration & dosage*; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000503:physiopathology
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D002186:Cannabinoids; D000069583:Pregabalin; D005283:Fentanyl