title: Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country.
abstract: BACKGROUND
  The authors aimed to compare TST with QuantiFERON-TB Gold In-Tube (QFT) for detecting latent tuberculosis infection (LTBI) in HIV-infected patients in Iran as a TB-medium endemic country.
  
  
  METHODS
  In a cross-sectional design,130 HIV-positive patients in HIV clinic of Tehran University were studied. Patients screened for LTBI with QFT and TST simultaneously. Concordance between 2 tests results and variables associated with tests discordance were assessed.
  
  
  RESULTS
  Positive results found in 24.6% for TST and 7.7% for QFT. Overall agreement between them was 73.85% (Kappa = 0.083). History of imprisonment was associated with more positive TST (P = 0.014) and QFT (P = 0.01). Patients with intravenous drug use (IDU) history had significant discordant results (0.018).
  
  
  CONCLUSIONS
  The authors recommend QFT for all negative cases of TST in HIV-positive patients especially who had history of IDU.
authors.affiliation: Department of Infectious Disease, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamideh
authors.initials: H
authors.lastname: Khazraiyan
authors.affiliation: Department of Infectious Disease, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra Abdi
authors.initials: ZA
authors.lastname: Liaei
authors.affiliation: Department of Infectious Disease, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid Emadi
authors.initials: HE
authors.lastname: Koochak
authors.affiliation: Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Farid Azmoudeh
authors.initials: FA
authors.lastname: Ardalan
authors.affiliation: Department of Infectious Disease, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ahmadinejad
authors.affiliation: Department of Disaster Public Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran a_soltani@razi.tums.ac.ir.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Soltani
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007492:Iran; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000302:isolation & purification; D014374:Tuberculin Test / Q000295:instrumentation / Q000379:methods*; D055815:Young Adult
keywords: HIV; QuantiFERON; diagnosis; latent tuberculosis; tuberculosis