title: 3D Printing and Biofabrication for Load Bearing Tissue Engineering.
abstract: Cell-based direct biofabrication and 3D bioprinting is becoming a dominant technological platform and is suggested as a new paradigm for twenty-first century tissue engineering. These techniques may be our next step in surpassing the hurdles and limitations of conventional scaffold-based tissue engineering, and may offer the industrial potential of tissue engineered products especially for load bearing tissues. Here we present a topically focused review regarding the fundamental concepts, state of the art, and perspectives of this new technology and field of biofabrication and 3D bioprinting, specifically focused on tissue engineering of load bearing tissues such as bone, cartilage, osteochondral and dental tissue engineering.
authors.affiliation: Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
authors.forename: Claire G
authors.initials: CG
authors.lastname: Jeong
authors.affiliation: Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA. aatala@wakehealth.edu.
authors.forename: Anthony
authors.initials: A
authors.lastname: Atala
mesh_terms: D001672:Biocompatible Materials / Q000378:metabolism*; D001842:Bone and Bones / Q000166:cytology / Q000502:physiology; D002356:Cartilage / Q000166:cytology / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D066330:Printing, Three-Dimensional; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014070:Tooth / Q000166:cytology / Q000502:physiology; D016474:Weight-Bearing
chemical_list: D001672:Biocompatible Materials
keywords: 3D printing; Biofabrication; Bone; Cartilage; Tissue engineering