title: Neuropharmacology of Poststroke Motor and Speech Recovery.
abstract: Almost 7 million adult Americans have had a stroke. There is a growing need for more effective treatment options as add-ons to conventional therapies. This article summarizes the published literature for pharmacologic agents used for the enhancement of motor and speech recovery after stroke. Amphetamine, levodopa, selective serotonin reuptake inhibitors, and piracetam were the most commonly used drugs. Pharmacologic augmentation of stroke motor and speech recovery seems promising but systematic, adequately powered, randomized, and double-blind clinical trials are needed. At this point, the use of these pharmacologic agents is not supported by class I evidence.
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center (UTHealth), The NeuroRecovery Research Center Houston, TIRR Memorial Hermann, Houston, 1333B Moursund Street, Room 126, Houston, TX 77030, USA.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Keser
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center (UTHealth), The NeuroRecovery Research Center Houston, TIRR Memorial Hermann, Houston, 1333 Moursund Street, Suite E-108, Houston, TX 77030, USA. Electronic address: Gerard.E.Francisco@uth.tmc.edu.
authors.forename: Gerard E
authors.initials: GE
authors.lastname: Francisco
mesh_terms: D006801:Humans; D000068079:Motor Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D020127:Recovery of Function / Q000187:drug effects*; D013064:Speech Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D020521:Stroke / Q000188:drug therapy* / Q000503:physiopathology
keywords: Motor; Neuropharmacology; Recovery; Speech; Stroke