title: Genetic variation in V gene of class II Newcastle disease virus.
abstract: The genetic variation and molecular evolution of the V gene of the class II Newcastle disease virus (NDV) isolates with genotypes I-XVIII were determined using bioinformatics. Results indicated that low homology existed in different genotype viruses, whereas high homology often for the same genotypes, exception may be existed within genotypes I, V, VI, and XII. Sequence analysis showed that the genetic variation of V protein was consistent with virus genotype, and specific signatures on the V protein for nine genotypes were identified. Phylogenetic analysis demonstrated that the phylogenetic trees were highly consistent between the V and F genes, with slight discrepancies in the sub-genotypes. Evolutionary rate analyses based on V and F genes revealed the evolution rates varied in genotypes. These data indicate that the genetic variation of V protein is genotype-related and will help in elucidating the molecular evolution of NDV.
authors.affiliation: College of Veterinary Medicine, Northwest A & F University, Yangling, 712100, Shaanxi, China.
authors.forename: Huafang
authors.initials: H
authors.lastname: Hao
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, 730046, Gansu, People's Republic of China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Chen
authors.affiliation: College of Veterinary Medicine, Northwest A & F University, Yangling, 712100, Shaanxi, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Northwest A & F University, Yangling, 712100, Shaanxi, China.
authors.forename: Shanhui
authors.initials: S
authors.lastname: Ren
authors.affiliation: College of Veterinary Medicine, Northwest A & F University, Yangling, 712100, Shaanxi, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Gao
authors.affiliation: College of Veterinary Medicine, Northwest A & F University, Yangling, 712100, Shaanxi, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Veterinary Medicine, Northwest A & F University, Yangling, 712100, Shaanxi, China.
authors.forename: Xinglong
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Veterinary Medicine, Northwest A & F University, Yangling, 712100, Shaanxi, China.
authors.forename: Shuxia
authors.initials: S
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Northwest A & F University, Yangling, 712100, Shaanxi, China. Electronic address: yzq8162@163.com.
authors.forename: Zengqi
authors.initials: Z
authors.lastname: Yang
mesh_terms: D019295:Computational Biology / Q000379:methods; D019143:Evolution, Molecular; D005838:Genotype; D009522:Newcastle disease virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D017423:Sequence Analysis, RNA / Q000379:methods; D014764:Viral Proteins / Q000235:genetics*
chemical_list: C070065:36 kDa V protein, Newcastle disease virus; D014764:Viral Proteins
keywords: Genetic variation; Newcastle disease virus; Phylogenetic analysis; Specific signature; V protein