title: Game of 'Somes: Protein Destruction for Mycobacterium tuberculosis Pathogenesis.
abstract: The proteasome system of Mycobacterium tuberculosis is required for causing disease. Proteasomes are multisubunit chambered proteases and, until recently, were only known to participate in adenosine triphosphate (ATP)-dependent proteolysis in bacteria. In this review, we discuss the latest advances in understanding how both ATP-dependent and ATP-independent proteasome-regulated pathways contribute to M. tuberculosis virulence.
authors.affiliation: New York University School of Medicine, Department of Microbiology, 550 First Avenue, MSB 236 New York, NY 10016, USA.
authors.forename: Marie I
authors.initials: MI
authors.lastname: Samanovic
authors.affiliation: New York University School of Medicine, Department of Microbiology, 550 First Avenue, MSB 236 New York, NY 10016, USA. Electronic address: heran.darwin@med.nyu.edu.
authors.forename: K Heran
authors.initials: KH
authors.lastname: Darwin
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000378:metabolism* / Q000472:pathogenicity*; D014376:Tuberculosis / Q000382:microbiology*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins
keywords: Mycobacterium tuberculosis; pathogenesis; proteasome; pupylation