title: Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases.
abstract: Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy. It continues to be an important health problem worldwide. Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, hepatosplenomegaly, cytopenias, high serum levels of ferritin and triglycerides, low serum fibrinogen levels, and hemophagocytosis in bone marrow, lymph nodes, spleen, or liver. Hemophagocytic lymphohistiocytosis associated with brucellosis is a very rare condition in the pediatric age group. Here, three pediatric cases of secondary HLH associated with brucellosis are reported. Hemophagocytic lymphohistiocytosis should be considered in patients with brucellosis having cytopenias. Hemophagocytosis in brucellosis seems to be cured with appropriate antibiotics and intravenous immunoglobulin.
authors.affiliation: Sütçü Imam University Medical School, Kahramanmaraş, Turkey. yontemyaman@gmail.com.
authors.forename: Yöntem
authors.initials: Y
authors.lastname: Yaman
authors.forename: Salih
authors.initials: S
authors.lastname: Gözmen
authors.forename: Ahmet Kağan
authors.initials: AK
authors.lastname: Özkaya
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Oymak
authors.forename: Hurşit
authors.initials: H
authors.lastname: Apa
authors.forename: Canan
authors.initials: C
authors.lastname: Vergin
authors.forename: İlker
authors.initials: İ
authors.lastname: Devrim
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002006:Brucellosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D016756:Immunoglobulins, Intravenous