title: Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease.
abstract: Behçet's disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gamma delta (γδ) T cells are reported to have a role. γδ T cells are atypical T cells, which represent a small proportion of total lymphocytes. They have features of both innate and adaptive immunity and express characteristics of conventional T cells, natural killer cells, and myeloid antigen presenting cells. These unconventional T cells are found in the inflammatory BD lesions and have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of the disease. Over the last 20 years there has been much interest in the role of γδ T cells in BD. We review the literature and discuss the roles that γδ T cells may play in BD pathogenesis.
authors.affiliation: Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Blizard Building, 4 Newark Street, London E1 2AT, UK.
authors.forename: Md Samiul
authors.initials: MS
authors.lastname: Hasan
authors.affiliation: Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Blizard Building, 4 Newark Street, London E1 2AT, UK.
authors.forename: Lesley Ann
authors.initials: LA
authors.lastname: Bergmeier
authors.affiliation: Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Blizard Building, 4 Newark Street, London E1 2AT, UK.
authors.forename: Harry
authors.initials: H
authors.lastname: Petrushkin
authors.affiliation: Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Blizard Building, 4 Newark Street, London E1 2AT, UK.
authors.forename: Farida
authors.initials: F
authors.lastname: Fortune
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D001528:Behcet Syndrome / Q000209:etiology* / Q000378:metabolism*; D006801:Humans; D056747:Immunomodulation; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*
chemical_list: D000941:Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta