title: HER3 over-expression and overall survival in gastrointestinal cancers.
abstract: Published studies on the association between human epidermal factor receptor 3 (HER3) expression and overall survival (OS) in gastrointestinal cancers have yielded conflicting results. The aim of this study was to explore the association of HER3 over-expression with OS in gastrointestinal cancers. A systematic search was performed through Medline/PubMed, Embase, Science Direct and Elsevier. The summary odds ratio (OR) with 95% confidence interval (CI) was calculated to estimate the strength of the association. Overall, we observed that HER3 over-expression was associated with worse OS at five years (OR = 1.38, 95% CI: 1.04-1.82); however, HER3 over-expression was not associated with worse OS at three years (OR = 1.33, 95% CI: 0.97-1.84). The cumulative meta-analysis showed similar results. In subgroup analyses by tumor type, HER3 over-expression in gastric cancers was associated with worse OS at both three years (OR = 1.69, 95% CI: 1.28-2.25) and five years (OR = 1.74, 95% CI: 1.26-2.41). In conclusion, our results suggest that HER3 over-expression may be associated with worse overall survival in gastric cancers. Well-designed studies with a large sample size are required to further confirm our findings.
authors.affiliation: Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.|Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Yang
authors.affiliation: Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China.
authors.forename: Guangcai
authors.initials: G
authors.lastname: Duan
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D005770:Gastrointestinal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D006801:Humans; D016017:Odds Ratio; D011379:Prognosis; D020893:Receptor, ErbB-3 / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; C581292:ERBB3 protein, human; D020893:Receptor, ErbB-3
keywords: HER3; gastrointestinal cancers; overall survival