title: The influence of female age on the cumulative live-birth rate of fresh cycles and subsequent frozen cycles using vitrified blastocysts in hyper-responders.
abstract: OBJECTIVE
  The aim of this research was to study the influence of female age on the cumulative live-birth rate of fresh and subsequent frozen cycles using vitrified blastocysts of the same cohort in hyper-responders.
  
  
  METHODS
  This was a retrospective study of 1137 infertile women undergoing their first in vitro fertilization treatment between 2006 and 2013. The main outcome measure was cumulative live births among the fresh and all vitrified blastocyst transfers combined after the same stimulation cycle. The results were also analyzed according to age (i.e., <35 years, 35-39 years, and ≥ 40 years).
  
  
  RESULTS
  The mean number of retrieved oocytes was 19.9 ± 8.5 oocytes. The cumulative pregnancy rate was 89.2% and the cumulative live-birth rate was 73.3%. The cumulative live-birth rate declined from 73.9% for women younger than 35 years old to 67.3% for women 35-39 years old to 57.9% for women 40 years or older.
  
  
  CONCLUSIONS
  Combined fresh and vitrified blastocyst transfer cycles can result in a high cumulative live-birth rate. The cumulative live-birth rates among older women are lower than the rates among younger women when autologous oocytes are used.
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Cheng-Hsuan
authors.initials: CH
authors.lastname: Wu
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Lee
authors.affiliation: Department of Life Sciences, College of Life Sciences, National Chung Hsing University, Taichung, Taiwan; Division of Infertility Clinic, Lee Womens' Hospital, Taichung, Taiwan.
authors.forename: Hsiu-Hui
authors.initials: HH
authors.lastname: Chen
authors.affiliation: Division of Infertility Clinic, Lee Womens' Hospital, Taichung, Taiwan.
authors.forename: Chung-I
authors.initials: CI
authors.lastname: Chen
authors.affiliation: Division of Infertility Clinic, Lee Womens' Hospital, Taichung, Taiwan.
authors.forename: Chun-Chia
authors.initials: CC
authors.lastname: Huang
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan; Division of Infertility Clinic, Lee Womens' Hospital, Taichung, Taiwan. Electronic address: msleephd@gmail.com.
authors.forename: Maw-Sheng
authors.initials: MS
authors.lastname: Lee
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D001723:Birth Rate; D001755:Blastocyst / Q000166:cytology*; D015925:Cryopreservation; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000453:epidemiology / Q000628:therapy*; D050498:Live Birth; D009865:Oocytes; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013624:Taiwan / Q000453:epidemiology; D058989:Vitrification
keywords: cumulative live-birth rate; female age; vitrified blastocyst