title: Spontaneous early-onset glomerulonephritis in a 8-week-old male Crj:CD1 (ICR) mouse.
abstract: Glomerular lesions including membranoproliferative glomerulonephritis occur spontaneously in aged mice, but they are rare in young animals. In our laboratory, spontaneous glomerulonephritis was observed in an 8-week-old male Crj:CD1 (ICR) mouse. Macroscopically, the bilateral kidneys were discolored, but no edema or ascites was observed. Glomerular lesions were characterized by a thickening of capillary walls, a double-contoured basement membrane and mesangial expansion due to increased amounts of matrix. Ultrastructurally, mesangial interposition in the capillary wall and subendothelial deposition of basement membrane-like material were observed. No evidence of immune complex deposition or amyloid was found. On the basis of the observed clinical pathology and histopathology, a secondary form of glomerular lesion was excluded. The glomerular lesion was compatible with glomerulonephritis in a young Crj:CD1 (ICR) mouse.
authors.affiliation: Toxicology Laboratory, Pharmaceutical Research Center, Meiji Seika Pharma Co., Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama, Kanagawa 222-8567, Japan.
authors.forename: Kyohei
authors.initials: K
authors.lastname: Ago
authors.affiliation: Research Institute of Biosciences, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan.
authors.forename: Go
authors.initials: G
authors.lastname: Sugahara
authors.affiliation: Research Institute of Biosciences, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan ; Laboratory of Veterinary Pathology, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan.
authors.forename: Kinji
authors.initials: K
authors.lastname: Shirota
authors.affiliation: Toxicology Laboratory, Pharmaceutical Research Center, Meiji Seika Pharma Co., Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama, Kanagawa 222-8567, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kurata
keywords: CD-1; glomerulonephritis; kidney; mouse; spontaneous