title: The Functions of BMP3 in Rabbit Articular Cartilage Repair.
abstract: Bone morphogenetic proteins (BMPs) play important roles in skeletal development and repair. Previously, we found fibroblast growth factor 2 (FGF2) induced up-regulation of BMP2, 3, 4 in the process of rabbit articular cartilage repair, which resulted in satisfactory repair effects. As BMP2/4 show a clearly positive effect for cartilage repair, we investigated the functions of BMP3 in rabbit articular cartilage repair. In this paper, we find that BMP3 inhibits the repair of partial-thickness defect of articular cartilage in rabbit by inducing the degradation of extracellular matrix, interfering with the survival of chondrocytes surrounding the defect, and directly inhibiting the expression of BMP2 and BMP4. Meanwhile BMP3 suppress the repair of full-thickness cartilage defect by destroying the subchondral bone through modulating the proliferation and differentiation of bone marrow stem cells (BMSCs), and directly increasing the expression of BMP4. Although BMP3 has different functions in the repair of partial and full-thickness defects of articular cartilage in rabbit, the regulation of BMP expression is involved in both of them. Together with our previous findings, we suggest the regulation of the BMP signaling pathway by BMP3 is essential in articular cartilage repair.
authors.affiliation: The Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College,Tianjin300192, China. zhangzhe523575127@163.com.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College,Tianjin300192, China. Yang_eve@163.com.
authors.forename: Wenyu
authors.initials: W
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College,Tianjin300192, China. 15933766189@163.com.
authors.forename: Yiting
authors.initials: Y
authors.lastname: Cao
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China. yanpingshi@126.com.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Shi
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China. leichen788@163.com.
authors.forename: Chen
authors.initials: C
authors.lastname: Lei
authors.affiliation: The Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College,Tianjin300192, China. dubojlu@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Du
authors.affiliation: The Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College,Tianjin300192, China. lixuemin-7205@vip.sina.com.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Li
authors.affiliation: The Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College,Tianjin300192, China. zhangqiq@126.com.
authors.forename: Qiqing
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D055398:Bone Morphogenetic Protein 3 / Q000235:genetics* / Q000378:metabolism*; D002358:Cartilage, Articular / Q000502:physiology* / Q000601:surgery; D002454:Cell Differentiation; D049109:Cell Proliferation; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D015870:Gene Expression; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D011817:Rabbits; D015398:Signal Transduction; D014945:Wound Healing
chemical_list: D055398:Bone Morphogenetic Protein 3
keywords: articular cartilage; bone morphogenetic protein 3; repair; subchondral bone