title: Activation of P-450-Dependent Monooxygenases Modulates the Diuretic Effect of Histochrome in Rats.
abstract: We studied the role of the liver monooxygenase system in pharmacological activity of histochrome, a pharmaceutical form of echinochrome A. In experiments on rats, benzonal, an inductor of the monooxygenase system of phenobarbytal type, significantly potentiated the diuretic effect of histochrome. Benzonal withdrawal was followed by a natriuretic reaction. In view of the known inverse relation between the biological effect of the drug and the rate of its metabolism, our findings suggest that the effects of echinochrome A on some kidney excretory function parameters are produced not by native agent, but one of its metabolites.
authors.affiliation: Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia. talalaeva_olga@mail.ru.
authors.forename: O S
authors.initials: OS
authors.lastname: Talalaeva
authors.affiliation: Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Bryukhanov
authors.affiliation: Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
authors.forename: Ya F
authors.initials: YF
authors.lastname: Zverev
authors.affiliation: Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Lampatov
authors.affiliation: Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Zharikov
authors.affiliation: Pacific Institute of Bioorganic Chemistry, Far-East Division of the Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Mischenko
authors.affiliation: Department of Psychiatry and Narcology, Altay State Medical University, Barnaul, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Sheremet'eva
mesh_terms: D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D005260:Female; D008099:Liver / Q000187:drug effects / Q000502:physiology; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism / Q000502:physiology*; D009285:Naphthoquinones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001463:Barbiturates; D004232:Diuretics; D009285:Naphthoquinones; C103614:histochrome; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C002915:benzobarbital
keywords: benzonal; histochrome; microsomal oxidation