title: Bioactivity of noble metal nanoparticles decorated with biopolymers and their application in drug delivery.
abstract: The unique properties of nanomaterials can be applied to solve different problems including new ways of drug delivery. Noble metal nanoparticles are most promising because they have been used for medicinal purposes since ancient time. It is evident from the past studies that the metallic nanoparticles are much more effective against various microorganisms when compared to their conventional counterparts. However, decoration of such nanoparticles with biomaterials add more advantages to their antimicrobial activity. Decoration of metal nanoparticles with biopolymers is a quite new area of research. Studies performed hitherto shown that nanoparticles of noble metals like silver, gold and platinum demonstrated better antibacterial, antifungal and antiviral activities when conjugated with biopolymers. The development of such technology has potential to develop materials that are more effective in the field of health science. Considering the importance and uniqueness of this concept, the present review aims to discuss the use of biopolymer-decorated metal nanoparticles for combating various diseases caused by microbial pathogens. Moreover, the nanotoxicity aspect has also been discussed.
authors.affiliation: Nanobiotechnology Laboratory, Department of Biotechnology, S.G.B. Amravati University, Amravati 444602, Maharashtra, India. Electronic address: mahendrarai@sgbau.ac.in.
authors.forename: Mahendra
authors.initials: M
authors.lastname: Rai
authors.affiliation: Nanobiotechnology Laboratory, Department of Biotechnology, S.G.B. Amravati University, Amravati 444602, Maharashtra, India.
authors.forename: Avinash P
authors.initials: AP
authors.lastname: Ingle
authors.affiliation: Nanobiotechnology Laboratory, Department of Biotechnology, S.G.B. Amravati University, Amravati 444602, Maharashtra, India; Department of Biotechnology, Institute of Science, Nipat Niranjan Nagar, Caves Road, Aurangabad 431004, Maharashtra, India.
authors.forename: Indarchand
authors.initials: I
authors.lastname: Gupta
authors.affiliation: Laboratório de Bioquímica e Microbiologia Aplicada, Departamento de Ciência de Alimentos, Universidade Federal do Rio Grande do Sul, 901501-970 Porto Alegre, Brazil.
authors.forename: Adriano
authors.initials: A
authors.lastname: Brandelli
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D001704:Biopolymers / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D006046:Gold / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D012834:Silver / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D001704:Biopolymers; D012834:Silver; D006046:Gold
keywords: Biopolymers; Drug delivery; Gold nanoparticles; Platinum nanoparticles; Silver nanoparticles; Toxicity