title: Hypofractionated Radiotherapy for Children With Diffuse Intrinsic Pontine Gliomas.
abstract: Children with diffuse intrinsic pontine gliomas have very poor outcomes, with nearly all children dying from disease. Standard therapy includes 6 weeks of radiation. There have been descriptions of using a shortened course of radiation. We describe our experience with a hypofractionated radiotherapy approach delivered over five treatments. In seven children, hypofractionated radiotherapy was well tolerated, but symptomatic radiation necrosis was seen in three of the children. Overall survival was slightly shorter than previously described in the literature. We are developing a prospective dose-finding protocol with the goal of tolerable short-course radiation treatment with outcomes comparable to conventional radiation.
authors.affiliation: Department of Pediatric Neurosurgery, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Hankinson
authors.affiliation: Department of Pediatric Neurosurgery, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Mohana Rao
authors.initials: MR
authors.lastname: Patibandla
authors.affiliation: Department of Pediatrics, Center for Cancer and Blood Disorders, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Adam
authors.initials: A
authors.lastname: Green
authors.affiliation: Department of Pediatrics, Center for Cancer and Blood Disorders, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Molly
authors.initials: M
authors.lastname: Hemenway
authors.affiliation: Department of Pediatrics, Center for Cancer and Blood Disorders, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Foreman
authors.affiliation: Department of Pediatric Neurosurgery, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Michael
authors.initials: M
authors.lastname: Handler
authors.affiliation: Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Arthur K
authors.initials: AK
authors.lastname: Liu
mesh_terms: D020295:Brain Stem Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D011149:Pons / Q000473:pathology* / Q000528:radiation effects; D000069473:Radiation Dose Hypofractionation; D012189:Retrospective Studies
keywords: diffuse intrinsic pontine glioma; hypofractionated radiotherapy; pediatric