title: Anxiolytic effects of ACE inhibitory peptides on the behavior of rats in an elevated plus-maze.
abstract: Three novel egg white-derived peptides were demonstrated to display in vitro activities against the angiotensin converting enzyme (ACE). A further study was conducted to assess their anxiolytic-like effects upon spontaneously hypertensive rats (SHRs) after an oral administration of the peptides, which showed the same behavioral performance as that using an elevated plus maze (EPM). In the EPM experiment, the behavioral effects of peptides TNGIIR, RVPSL, and QIGLF were investigated at doses ranging from 5 to 50 mg kg(-1), with records of the number of entries by the rats into the open arms, the time the rats spent in the open arms, and the total amount of entries into the open + closed arms. The results showed that the peptides TNGIIR and RVPSL, in a range of 5-50 mg kg(-1), exerted an anxiolytic effect on the SHRs. These results suggested that the egg white derived peptides TNGIIR and RVPSL could be considered as possible functional food or food ingredients due to their in vivo anti-stress and anti-anxiety effects on the SHRs.
authors.affiliation: College of Food Science and Engineering, Bohai University, Jinzhou 121013, P.R. China. zhaowenzhu777@163.com.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Yu
authors.affiliation: College of Food Science and Engineering, Bohai University, Jinzhou 121013, P.R. China. zhaowenzhu777@163.com.
authors.forename: Wenzhu
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Lab of Nutrition and Functional Food, Jilin University, Changchun 130062, P.R. China. ljb168@sohu.com.
authors.forename: Long
authors.initials: L
authors.lastname: Ding
authors.affiliation: Lab of Nutrition and Functional Food, Jilin University, Changchun 130062, P.R. China. ljb168@sohu.com.
authors.forename: Yiding
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Lab of Nutrition and Functional Food, Jilin University, Changchun 130062, P.R. China. ljb168@sohu.com.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Liu
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004527:Egg Proteins / Q000737:chemistry*; D018782:Maze Learning / Q000187:drug effects*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011487:Protein Conformation; D051381:Rats
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D014151:Anti-Anxiety Agents; D004527:Egg Proteins; D010455:Peptides