title: Transplantation of mesenchymal stem cells in a laryngeal carcinoma patient with radiation myelitis.
abstract: Radiation myelitis is a rather rare but devastating complication following therapeutic irradiation to neoplasms when the spinal cord is included within the radiation field. Symptoms of radiation myelitis with the therapeutic doses of radiation commonly employed are usually delayed and most often appear about 6 to 24 months following irradiation. So far, no treatment has proved satisfactory.Transplantation of allogeneic mesenchymal stem cells has been a promising therapy strategy for many disorders in the central nervous system, such as multiple sclerosis, neuromyelitis optica, and autoimmune encephalomyelitis. The cell-base therapy has shown to act to limit inflammation of central nervous system, stimulate neurogenesis, protect axons and promote remyelination. But it has not been established as a therapeutic option for radiation myelitis.In this report, we describe the outcome of allogeneic umbilical cord-derived mesenchymal stem cell transplantation in a patient with laryngeal carcinoma who developed radiation-induced myelitis of his spinal cord with characteristic magnetic resonance imaging changes.
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, CN, 210008, P. R. China. liangjunlzk@hotmail.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, CN, 210008, P. R. China. 270043834@qq.com.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, CN, 210008, P. R. China. dandanwang2007@yahoo.com.cn.
authors.forename: Dandan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, CN, 210008, P. R. China. 13770560567@163.com.
authors.forename: Huayong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, CN, 210008, P. R. China. zhaochengjs@sina.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, CN, 210008, P. R. China. shuiyeziying@163.com.
authors.forename: Shiying
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, CN, 210008, P. R. China. lingyunsun2012@163.com.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Sun
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D009187:Myelitis / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects
chemical_list: D000305:Adrenal Cortex Hormones