title: AMPK Function in Aging Process.
abstract: Aging involves the progressive deterioration of physiological functions, diminishing the individual's capacity for survival. Indeed, aging is the main risk factor for cancer, diabetes, cardiovascular disorders and neurodegenerative diseases. The discovery that the rate of aging is controlled by conserved genetic and biochemical pathways represented an unprecedented advance in aging research. The AMPK protein is a metabolic sensor that acts as a qualified cellular housekeeper, as well as controlling energy homeostasis and resistance to stress. Thus, the correct regulation of this factor enhances health and survival. In this manuscript we will review the molecular pathways regulated by AMPK that are related to the aging process, paying special attention to mitochondrial dysfunction, metabolic deregulation, cell senescence and autophagy.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Calle Profesor García González 2, 41012 Sevilla, Spain. rruizlaza@us.es.
authors.forename: Rocío
authors.initials: R
authors.lastname: Ruiz
authors.forename: Eva María
authors.initials: EM
authors.lastname: Pérez-Villegas
authors.affiliation: Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Ctra de Utrera Km 1, 41013 Sevilla, Spain. amancar@upo.es.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Manuel Carrión
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000375:Aging / Q000502:physiology*; D000818:Animals; D001343:Autophagy; D016922:Cellular Senescence; D015971:Gene Expression Regulation, Enzymologic; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D010766:Phosphorylation; D015398:Signal Transduction
chemical_list: D055372:AMP-Activated Protein Kinases