title: Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels.
abstract: Coupling of peptide self-assembly to dynamic sequence exchange provides a useful approach for the discovery of self-assembling materials. In here, we demonstrate the discovery and optimization of aqueous, gel-phase nanostructures based on dynamically exchanging peptide sequences that self-select to maximize charge transfer of n-type semiconducting naphthalenediimide (NDI)-dipeptide bioconjugates with various π-electron-rich donors (dialkoxy/hydroxy/amino-naphthalene or pyrene derivatives). These gel-phase peptide libraries are characterized by spectroscopy (UV-vis and fluorescence), microscopy (TEM), HPLC, and oscillatory rheology and it is found that, of the various peptide sequences explored (tyrosine Y-NDI with tyrosine Y, phenylalanine F, leucine L, valine V, alanine A or glycine G-NH2), the optimum sequence is tyrosine-phenylalanine in each case; however, both its absolute and relative yield amplification is dictated by the properties of the donor component, indicating cooperativity of peptide sequence and donor/acceptor pairs in assembly. The methodology provides an in situ discovery tool for nanostructures that enable dynamic interfacing of supramolecular electronics with aqueous (biological) systems.
authors.affiliation: WestCHEM/Department of Pure and Applied Chemistry, University of Strathclyde , Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.|Departament de Química Inorgànica i Orgànica, Universitat Jaume I , Avda. Sos Baynat s/n, 12071 Castelló, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Berdugo
authors.affiliation: WestCHEM/Department of Pure and Applied Chemistry, University of Strathclyde , Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
authors.forename: Siva Krishna Mohan
authors.initials: SK
authors.lastname: Nalluri
authors.affiliation: WestCHEM/Department of Pure and Applied Chemistry, University of Strathclyde , Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.
authors.forename: Nadeem
authors.initials: N
authors.lastname: Javid
authors.affiliation: Departament de Química Inorgànica i Orgànica, Universitat Jaume I , Avda. Sos Baynat s/n, 12071 Castelló, Spain.
authors.forename: Beatriu
authors.initials: B
authors.lastname: Escuder
authors.affiliation: Departament de Química Inorgànica i Orgànica, Universitat Jaume I , Avda. Sos Baynat s/n, 12071 Castelló, Spain.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Miravet
authors.affiliation: WestCHEM/Department of Pure and Applied Chemistry, University of Strathclyde , Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.|Advanced Science Research Center (ASRC) and Hunter College, City University of New York (CUNY) , 85 St Nicholas Terrace, New York, New York 10031, United States.
authors.forename: Rein V
authors.initials: RV
authors.lastname: Ulijn
mesh_terms: D000595:Amino Acid Sequence; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D020100:Hydrogels / Q000737:chemistry*; D019151:Peptide Library; D013050:Spectrometry, Fluorescence; D013816:Thermodynamics; D013820:Thermolysin / Q000378:metabolism; D013997:Time Factors
chemical_list: D020100:Hydrogels; D019151:Peptide Library; D013820:Thermolysin
keywords: charge transfer interactions; dynamic combinatorial libraries; hydrogels; peptide derivatives; self-assembly; supramolecular electronics; thermolysin