title: Real-time automated EEG tracking of brain states using neural field theory.
abstract: A real-time fitting system is developed and used to fit the predictions of an established physiologically-based neural field model to electroencephalographic spectra, yielding a trajectory in a physiological parameter space that parametrizes intracortical, intrathalamic, and corticothalamic feedbacks as the arousal state evolves continuously over time. This avoids traditional sleep/wake staging (e.g., using Rechtschaffen-Kales stages), which is fundamentally limited because it forces classification of continuous dynamics into a few discrete categories that are neither physiologically informative nor individualized. The classification is also subject to substantial interobserver disagreement because traditional staging relies in part on subjective evaluations. The fitting routine objectively and robustly tracks arousal parameters over the course of a full night of sleep, and runs in real-time on a desktop computer. The system developed here supersedes discrete staging systems by representing arousal states in terms of physiology, and provides an objective measure of arousal state which solves the problem of interobserver disagreement. Discrete stages from traditional schemes can be expressed in terms of model parameters for backward compatibility with prior studies.
authors.affiliation: School of Physics, University of Sydney, New South Wales 2006, Australia; Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia; Neurosleep, 431 Glebe Point Rd, Glebe, New South Wales 2037, Australia; Brain Dynamics Center, Sydney Medical School - Western, University of Sydney, Westmead, New South Wales 2145, Australia. Electronic address: r.abeysuriya@physics.usyd.edu.au.
authors.forename: R G
authors.initials: RG
authors.lastname: Abeysuriya
authors.affiliation: School of Physics, University of Sydney, New South Wales 2006, Australia; Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia; Neurosleep, 431 Glebe Point Rd, Glebe, New South Wales 2037, Australia; Brain Dynamics Center, Sydney Medical School - Western, University of Sydney, Westmead, New South Wales 2145, Australia.
authors.forename: P A
authors.initials: PA
authors.lastname: Robinson
mesh_terms: D000465:Algorithms; D001143:Arousal / Q000502:physiology; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D008959:Models, Neurological; D012890:Sleep / Q000502:physiology*
keywords: EEG; Modeling; Neural field theory; Neurophysiology; Sleep