title: Social disruption alters pain and cognition in an animal model of multiple sclerosis.
abstract: Although pain and cognitive deficits are widespread and debilitating symptoms of multiple sclerosis (MS), they remain poorly understood. Theiler's murine encephalomyelitis virus (TMEV) infection is an animal model of MS where disease course is exacerbated by prior stressors. Here chronic infection coupled with prior social stress increased pain behavior and impaired hippocampal-dependent memory consolidation during the demyelinating phase of disease in SJL mice. These results suggest that the TMEV model may be useful in investigating pain and cognitive impairments in MS. However, in contrast to prior Balb/cJ studies, stress failed to consistently alter behavioral and physiological indicators of disease course.
authors.affiliation: Department of Psychology, Texas A&M University, College Station, TX, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, United States.
authors.forename: H R
authors.initials: HR
authors.lastname: Linsenbardt
authors.affiliation: Department of Psychology, Texas A&M University, College Station, TX, United States.
authors.forename: J L
authors.initials: JL
authors.lastname: Cook
authors.affiliation: Department of Psychology, Texas A&M University, College Station, TX, United States.
authors.forename: E E
authors.initials: EE
authors.lastname: Young
authors.affiliation: Department of Psychology, Texas A&M University, College Station, TX, United States.
authors.forename: E G
authors.initials: EG
authors.lastname: Vichaya
authors.affiliation: Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States.
authors.forename: C R
authors.initials: CR
authors.lastname: Young
authors.affiliation: Department of Psychology, Texas A&M University, College Station, TX, United States.
authors.forename: N M
authors.initials: NM
authors.lastname: Reusser
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, United States.
authors.forename: R
authors.initials: R
authors.lastname: Storts
authors.affiliation: Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, United States; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States.
authors.forename: C J
authors.initials: CJ
authors.lastname: Welsh
authors.affiliation: Department of Psychology, Texas A&M University, College Station, TX, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, United States. Electronic address: m-meagher@tamu.edu.
authors.forename: M W
authors.initials: MW
authors.lastname: Meagher
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D018188:Cardiovirus Infections / Q000150:complications / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009103:Multiple Sclerosis / Q000150:complications / Q000523:psychology; D010146:Pain / Q000209:etiology*; D013315:Stress, Psychological / Q000150:complications*; D017945:Theilovirus
keywords: Cognition; Multiple sclerosis; Pain; Pavlovian conditioning; Social stress; Theiler's murine encephalomyelitis virus