title: UniProtKB/Swiss-Prot, the Manually Annotated Section of the UniProt KnowledgeBase: How to Use the Entry View.
abstract: The Universal Protein Resource (UniProt, http://www.uniprot.org ) consortium is an initiative of the SIB Swiss Institute of Bioinformatics (SIB), the European Bioinformatics Institute (EBI) and the Protein Information Resource (PIR) to provide the scientific community with a central resource for protein sequences and functional information. The UniProt consortium maintains the UniProt KnowledgeBase (UniProtKB), updated every 4 weeks, and several supplementary databases including the UniProt Reference Clusters (UniRef) and the UniProt Archive (UniParc).The Swiss-Prot section of the UniProt KnowledgeBase (UniProtKB/Swiss-Prot) contains publicly available expertly manually annotated protein sequences obtained from a broad spectrum of organisms. Plant protein entries are produced in the frame of the Plant Proteome Annotation Program (PPAP), with an emphasis on characterized proteins of Arabidopsis thaliana and Oryza sativa. High level annotations provided by UniProtKB/Swiss-Prot are widely used to predict annotation of newly available proteins through automatic pipelines.The purpose of this chapter is to present a guided tour of a UniProtKB/Swiss-Prot entry. We will also present some of the tools and databases that are linked to each entry.
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, rue Michel Servet 1, CH-1211, Geneva 4, Switzerland. emmanuel.boutet@isb-sib.ch.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Boutet
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, rue Michel Servet 1, CH-1211, Geneva 4, Switzerland.
authors.forename: Damien
authors.initials: D
authors.lastname: Lieberherr
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, rue Michel Servet 1, CH-1211, Geneva 4, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Tognolli
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, rue Michel Servet 1, CH-1211, Geneva 4, Switzerland.
authors.forename: Michel
authors.initials: M
authors.lastname: Schneider
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, rue Michel Servet 1, CH-1211, Geneva 4, Switzerland.
authors.forename: Parit
authors.initials: P
authors.lastname: Bansal
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, rue Michel Servet 1, CH-1211, Geneva 4, Switzerland.
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Bridge
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, rue Michel Servet 1, CH-1211, Geneva 4, Switzerland.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Poux
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, rue Michel Servet 1, CH-1211, Geneva 4, Switzerland.
authors.forename: Lydie
authors.initials: L
authors.lastname: Bougueleret
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, rue Michel Servet 1, CH-1211, Geneva 4, Switzerland.|University of Lausanne, CIG, Lausanne, 1015, Switzerland.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Xenarios
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D006801:Humans; D064878:Web Browser
keywords: Amino-acid sequence; Manual annotation; Protein database; Swiss-Prot; TrEMBL; UniProt