title: Activated Regulatory T Cells Expressing CD4(+)CD25(high)CD45RO(+)CD62L(+) Biomarkers Could Be a Risk Factor in Liver Allograft Rejection.
abstract: Activated regulatory T cells (aTregs) are nowadays a hot topic in organ transplantation to establish their role during acute rejection (AR) episodes. The aim of this multi-center study was to monitor the frequency of aTregs within the first year after transplantation in a cohort of first-time liver transplant recipients enrolled from 2010 to 2012. aTregs frequency was analyzed by means of flow cytometry. Patients who had AR showed higher levels of aTregs during first year after transplantation in comparison with patients who did not have higher levels. High levels of aTregs in liver recipients might be used as a biomarker of AR; however, further studies must be done to address the potential role of aTregs as biomarkers of AR in liver transplantation.
authors.affiliation: Immunology Service and Digestive Service, University Clinical Hospital Virgen Arrixaca-IMIB, Murcia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Boix
authors.affiliation: Pharmacology Laboratory (CDB) and Liver Unit, Clinic Hospital, IDIBAPS, CIBERehd, Barcelona, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Millan
authors.affiliation: Immunology Service and Digestive Unit, University Hospital Marqués de Valdecilla-IFIMAV, Santander, Spain.
authors.forename: D
authors.initials: D
authors.lastname: San Segundo
authors.affiliation: Immunology Service, University Hospital 12 de Octubre, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Mancebo
authors.affiliation: Immunology Service and Digestive Service, University Clinical Hospital Virgen Arrixaca-IMIB, Murcia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Miras
authors.affiliation: Pharmacology Laboratory (CDB) and Liver Unit, Clinic Hospital, IDIBAPS, CIBERehd, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rimola
authors.affiliation: Immunology Service and Digestive Unit, University Hospital Marqués de Valdecilla-IFIMAV, Santander, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Fábrega
authors.affiliation: Immunology Service, University Hospital 12 de Octubre, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Allende
authors.affiliation: Immunology Service and Digestive Service, University Clinical Hospital Virgen Arrixaca-IMIB, Murcia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Minguela
authors.affiliation: Immunology Service, University Hospital 12 de Octubre, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Paz-Artal
authors.affiliation: Immunology Service and Digestive Unit, University Hospital Marqués de Valdecilla-IFIMAV, Santander, Spain.
authors.forename: M
authors.initials: M
authors.lastname: López-Hoyos
authors.affiliation: Pharmacology Laboratory (CDB) and Liver Unit, Clinic Hospital, IDIBAPS, CIBERehd, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Brunet
authors.affiliation: Immunology Service and Digestive Service, University Clinical Hospital Virgen Arrixaca-IMIB, Murcia, Spain. Electronic address: manuel.muro@carm.es.
authors.forename: M
authors.initials: M
authors.lastname: Muro
mesh_terms: D000328:Adult; D064591:Allografts / Q000276:immunology; D015415:Biomarkers; D015704:CD4 Antigens / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D005260:Female; D005434:Flow Cytometry; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D019041:L-Selectin / Q000276:immunology; D017493:Leukocyte Common Antigens / Q000276:immunology; D008099:Liver / Q000276:immunology; D017093:Liver Failure / Q000601:surgery*; D008113:Liver Neoplasms / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D015415:Biomarkers; D015704:CD4 Antigens; D007166:Immunosuppressive Agents; D053645:Interleukin-2 Receptor alpha Subunit; D019041:L-Selectin; D017493:Leukocyte Common Antigens