title: Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease.
abstract: We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism assay was used to assess the polymorphisms PAR1 IVS-14 A/T rs168753 and -506 I/D rs11267092. The frequency of the AA genotype in PAR1 IVS-14 A/T rs168753 was significantly higher than in the controls (χ(2) = 7.23, P = 0.03). By logistic regression analysis, we found that the AA genotype of PAR1 IVS-14 A/T rs168753 was associated with increased risk of COPD compared with the GG genotype. The adjusted OR (95%CI) was 2.00 (1.15-3.50) for the AA genotype. In conclusion, we found that the PAR1 IVS-14 A/T rs168753 polymorphism was associated with the development of COPD.
authors.affiliation: Department of Senile Disease, Tai'an Central Hospital of Shandong Province, Tai'an, China chunmei_yy@163.com.
authors.forename: C M
authors.initials: CM
authors.lastname: Yun
authors.affiliation: Department of Senile Disease, Tai'an Central Hospital of Shandong Province, Tai'an, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Sang
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D044463:Receptor, PAR-1 / Q000235:genetics*; D012307:Risk Factors
chemical_list: D044463:Receptor, PAR-1