title: Synthesis and antiproliferativeactivity of new vinca alkaloids containing an α,β-unsaturated aromatic side chain.
abstract: A new series of vinca-alkaloids derivatives containing various α,β-unsaturated aromatic side chains was synthesized. Four new vinca-alkaloids derivatives showed selective cytotoxicities against KB tumor cell lines with IC50 value below 0.1 μM, thus comparable with vinblastine.
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi, Viet Nam. Electronic address: ngoquocanh74m@yahoo.com.
authors.forename: Quoc Anh
authors.initials: QA
authors.lastname: Ngo
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi, Viet Nam.
authors.forename: Le Anh
authors.initials: le A
authors.lastname: Nguyen
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi, Viet Nam.
authors.forename: Ngoc Binh
authors.initials: NB
authors.lastname: Vo
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi, Viet Nam.
authors.forename: Thuy Hang
authors.initials: TH
authors.lastname: Nguyen
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, UPR 2301 du CNRS, Université Paris Sud, 1 avenue de la terrasse, 91198 Gif sur Yvette Cedex, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Roussi
authors.affiliation: Ministry of Science and Technology, Viet Nam.
authors.forename: The Hung
authors.initials: TH
authors.lastname: Nguyen
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi, Viet Nam.
authors.forename: Van Tuyen
authors.initials: VT
authors.lastname: Nguyen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000737:chemistry / Q000627:therapeutic use*; D014748:Vinca Alkaloids / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014748:Vinca Alkaloids; D014747:Vinblastine
keywords: Cytotoxicity; Sarcodictyins; Tubulin; Vinca alkaloids