title: The Association Between Primary Open Angle Glaucoma and Clustered Components of Metabolic Syndrome.
abstract: OBJECTIVE
  There is conflicting evidence whether components of metabolic syndrome (MetS) increase or decrease the risk of primary open-angle glaucoma (POAG). The aim of the present study was to determine the association between metabolic syndrome and primary open-angle glaucoma.
  
  
  METHODS
  A total of 200 participants comprising 100 controls and 100 patients with POAG documented by clinical tests and examined by an experienced ophthalmologist using standard ophthalmologic equipment were included in the study. MetS was defined and based on ATP III criteria and POAG was defined by the criteria of the International Society of Geographic and Epidemiological Ophthalmology (ISGEO). The data were entered into the SPSS software and analyzed.
  
  
  RESULTS
  The prevalence of MetS in the glaucoma group was 53% in comparison to 38% in the control group (p=0.037). MetS was associated with an increased odds ratio for an IOP higher than 21 mmHg (OR: 1.72; 95% CI 1.03-2.79; p=0.034). The mean IOP was 24.91±4.29 mmHg in the patients without MetS, and 27.23±4.81 mmHg in those with MetS (p=0.027). The mean values of CCT were 603.64±63.16 µm in MetS patients and 579.27±72.87 µm in controls (p=0.018).
  
  
  CONCLUSIONS
  Data showed an increased prevalence of components of metabolic syndrome in patients with glaucoma. The mechanisms underlying these associations need to be established in future studies. Our results support the recommendation that patients with metabolic syndrome undergo regular ophthalmological exams to monitor for the onset or progression of glaucoma.
authors.affiliation: Department of Ophthalmology, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Seyed Ahmad
authors.initials: SA
authors.lastname: Rasoulinejad
authors.affiliation: Department of Ophthalmology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Kasiri
authors.affiliation: Department of Cardiology, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Montazeri
authors.affiliation: Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Negin
authors.initials: N
authors.lastname: Rashidi
authors.affiliation: Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Montazeri
authors.affiliation: Young Researchers Club, Islamic Azad University, Babol Branch, Babol, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Montazeri
authors.affiliation: Department of Ophthalmology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Hesam
authors.initials: H
authors.lastname: Hedayati
keywords: Central corneal thickness; intraocular pressure; metabolic syndrome; open-angle glaucoma