title: Circular dichroism sensor based on cadmium sulfide quantum dots for chiral identification and detection of penicillamine.
abstract: A new chemical sensor based on the measuring of circular dichroism signal (CD) was fabricated from cysteamine capped cadmium sulfide quantum dots (Cys-CdS QDs). The chiral-thiol molecules, d-penicillamine (DPA) and l-penicillamine (LPA), were used to evaluate potentials of this sensor. Basically, DPA and LPA provide very low CD signals. However, the CD signals of DPA and LPA can be enhanced in the presence of Cys-CdS QDs. The CD spectra of DPA and LPA exhibited a mirror image profile. Parameters affecting the determination of DPA and LPA were thoroughly investigated in details. Under the optimized condition, the CD signals of DPA and LPA displayed a linear relationship with the concentrations of both enantiomers, ranging from 1 to 35 μM. Detection limits of this sensor were 0.49 and 0.74 μM for DPA and LPA, respectively. To demonstrate a potential application of this sensor, the proposed sensor was used to determine DPA and LPA in real urine samples. It was confirmed that the proposed detection technique was reliable and could be utilized in a broad range of applications.
authors.affiliation: Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
authors.forename: Kessarin
authors.initials: K
authors.lastname: Ngamdee
authors.affiliation: Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
authors.forename: Theerapong
authors.initials: T
authors.lastname: Puangmali
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
authors.forename: Thawatchai
authors.initials: T
authors.lastname: Tuntulani
authors.affiliation: Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand. Electronic address: wittayange@kku.ac.th.
authors.forename: Wittaya
authors.initials: W
authors.lastname: Ngeontae
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D002942:Circular Dichroism / Q000295:instrumentation*; D010396:Penicillamine / Q000032:analysis*; D045663:Quantum Dots; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D013440:Sulfides; C034939:cadmium sulfide; D010396:Penicillamine
keywords: Chemical sensors; Chiral identification; Circular dichroism; Penicillamine; Quantum dots