title: Mini-review: diabetic renal complications, a potential stinky remedy.
abstract: Chronic kidney disease is associated with vasculitis and is also an independent risk factor for peripheral vascular and coronary artery disease in diabetic patients. Despite optimal management, a significant number of patients progress toward end-stage renal disease (ESRD), a suggestion that the disease mechanism is far from clear. A reduction in hydrogen sulfide (H2S) has been suggested to play a vital role in diabetic vascular complications including diabetic nephropathy (DN). This mini-review highlights the recent findings on the role of H2S in mitigating abnormal extracellular matrix metabolism in DN. A discussion on the development of the newer slow-releasing H2S compounds and its therapeutic potential is also included.
authors.affiliation: Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky u0sen001@louisville.edu.
authors.forename: Utpal
authors.initials: U
authors.lastname: Sen
authors.affiliation: Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky.
authors.forename: Sathnur
authors.initials: S
authors.lastname: Pushpakumar
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*
chemical_list: D006862:Hydrogen Sulfide
keywords: NMDA receptor; diabetic nephropathy; hydrogen sulfide; remodeling; signaling