title: TM4SF5-CTD-2354A18.1-miR-4697-3P may play a key role in the pathogenesis of gastric cancer.
abstract: OBJECTIVE
  Our aim is to identify important lncRNAs and mRNAs which may play a key role in contributing to pathogenesis of gastric cancer.
  
  
  METHODS
  Different LncRNAs and mRNAs are identified by microarray in gastric cancer tissue and corresponding normal tissues. The function and relationship of different LncRNAs and mRNAs is performed by GO analysis and Pathway analysis and made code-non-code network (CNC) by Pearson correlation coefficients (PCC). Then mRNA-miRNA relationship is predicted through mRNA-miRNA relationship software (http://www.targetscan.org). Lastly, mRNA-miRNA-LncRNA network is established for further research.
  
  
  RESULTS
  The expression proﬁles of 3732 lncRNAs showed different expression (fold change (FC)≥2.0, p<0.05) in gastric cancer tissue and normal tissue and expression proﬁles of 3994 mRNAs also showed different expression (FC≥2.0, p<0.05) in gastric cancer and corresponding normal tissue.
  
  
  CONCLUSIONS
  The expression of TM4SF5, CTD-2354A18.1 and miR-4697-3P is in balance at physiological conditions, however, the balance is disrupted by some situations, which may contribute to gastric cancer. GO analysis and Pathway analysis also showed TM4SF5 played an important role in proliferation, differentiation and apoptosis. Therefore, TM4SF5-miR-4697-3P- CTD-2354A18.1 may play a key role in the pathogenesis of gastric cancer (Tab. 2, Fig. 4, Ref. 30).
authors.forename: D F
authors.initials: DF
authors.lastname: Li
authors.forename: M F
authors.initials: MF
authors.lastname: Yang
authors.forename: S L
authors.initials: SL
authors.lastname: Shi
authors.forename: Y L
authors.initials: YL
authors.lastname: Du
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: Y L
authors.initials: YL
authors.lastname: Zhou
authors.forename: Y L
authors.initials: YL
authors.lastname: Luo
authors.forename: L L
authors.initials: LL
authors.lastname: Ren
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Nie
mesh_terms: D017209:Apoptosis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D008565:Membrane Proteins; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm; C111029:TM4SF5 protein, human
keywords: CTD-2354A18; TM4SF5; gastric cancer.; miR-4697-3P; microarray