title: Structure, Function, and Drug Interactions of Neurotransmitter Transporters in the Postgenomic Era.
abstract: Vesicular neurotransmitter transporters are responsible for the accumulation of neurotransmitters in secretory vesicles and play essential roles in chemical transmission. The SLC17 family contributes to sequestration of anionic neurotransmitters such as glutamate, aspartate, and nucleotides. Identification and subsequent cellular and molecular biological studies of SLC17 transporters unveiled the principles underlying the actions of these transporters. Recent progress in reconstitution methods in combination with postgenomic approaches has advanced studies on neurotransmitter transporters. This review summarizes the molecular properties of SLC17-type transporters and recent findings regarding the novel SLC18 transporter.
authors.affiliation: Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan; email: moriyama@pheasant.pharm.okayama-u.ac.jp , omote@pheasant.pharm.okayama-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Omote
authors.affiliation: Advanced Science Research Center, Okayama University, Okayama 700-8530, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Miyaji
authors.affiliation: Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan; email: moriyama@pheasant.pharm.okayama-u.ac.jp , omote@pheasant.pharm.okayama-u.ac.jp.
authors.forename: Miki
authors.initials: M
authors.lastname: Hiasa
authors.affiliation: Advanced Science Research Center, Okayama University, Okayama 700-8530, Japan.
authors.forename: Narinobu
authors.initials: N
authors.lastname: Juge
authors.affiliation: Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan; email: moriyama@pheasant.pharm.okayama-u.ac.jp , omote@pheasant.pharm.okayama-u.ac.jp.|Advanced Science Research Center, Okayama University, Okayama 700-8530, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Moriyama
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D004347:Drug Interactions / Q000502:physiology*; D006801:Humans; D050481:Vesicular Neurotransmitter Transport Proteins / Q000378:metabolism*
chemical_list: D050481:Vesicular Neurotransmitter Transport Proteins
keywords: SLC17; purification; reconstitution; transporter; vesicular neurotransmitter transporter