title: [Sinonasal polyposis associated with a deficiency subclass immunoglobulin G: Place of substitution immunoglobulins].
abstract: OBJECTIVE
  To study the effect of the introduction of a substitution by intravenous Immunoglobulins (Ig IV) at patients with immunoglobulins G (IgG) subclasses deficiency and nasal polyposis.
  
  
  METHODS
  Prospective study concerning five patients with IgG subclasses deficiency and nasal polyposis treated by Ig IV. Rhinologic, otologic and pulmonary symptoms, exacerbations of nasal polyposis, chronic otitis and asthma as well as the number of antibiotics and corticoids treatments were counted during the Ig IV substitution.
  
  
  OBJECTIVE
  To study the association between IgIV substitution and the number of exacerbations of nasal polyposis, chronic otitis, asthma and the number of antibiotics and corticoids treatments in patients with IgG subclasses deficiency and nasal polyposis.
  
  
  RESULTS
  Five patients with a IgG subclass deficiency and nasal polyposis were substituted. The number of antibiotics and corticoids cures increased at one patient and remained stable at four others. The number of sinus, ear and lung infections as well as the global rhinologic score of symptoms and the endoscopic stage of the nasal polyposis remained stable. In the absence of efficiency of the treatment, this one was interrupted at the end of 6 months for patients n° 1 and n° 3, 24 months for patient n° 4 and 42 months for patient n° 5.
  
  
  CONCLUSIONS
  The current study failed to highlight clinical improvement in patients wih IgG subclasses deficiency and nasal polyposis treated by Ig IV. A previous study had not allowed to find a link between IgG subclasses deficiency and severity of nasal polyposis, what seems to be confirmed by the absence of improvement brought during the substitution of this deficit in the current study.
authors.forename: Nhung Tran Khai
authors.initials: NT
authors.lastname: Hoan
authors.forename: M
authors.initials: M
authors.lastname: Karmochkine
authors.forename: O
authors.initials: O
authors.lastname: Laccourreye
authors.forename: P
authors.initials: P
authors.lastname: Bonfils
mesh_terms: D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D007074:Immunoglobulin G / Q000145:classification; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications* / Q000628:therapy; D011446:Prospective Studies; D012307:Risk Factors; D012852:Sinusitis / Q000150:complications* / Q000628:therapy; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors