title: Predictive factors of splanchnic vein thrombosis in acute pancreatitis: A 6-year single-center experience.
abstract: OBJECTIVE
  Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single-center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors.
  
  
  METHODS
  All consecutive patients with acute pancreatitis (AP) managed in our hospital were included. The primary outcome was the occurrence of SVT and data was collected in accordance with Ranson's criteria.
  
  
  RESULTS
  A total of 318 patients were included, of whom 124 (39.0%) were women. Biliary lithiasis was the main cause of pancreatitis (n = 156, 49.1%). A total of 19 (6.0%) SVT were identified. In univariate analysis, alcohol intake, smoking and male gender were associated with SVT (P = 0.005, 0.003 and 0.007, respectively). Biological parameters significantly associated with thrombosis were lactate dehydrogenase (LDH) < 500 U/L and hyperglycemia (≥ 10 mmol/L) (P = 0.009 and 0.016, respectively). In multivariate analysis, prothrombin time >75% was a protective factor against thrombosis (OR 0.148, P = 0.019). Leukocytes >10 × 10(9)/L (OR 6.397, P = 0.034), hyperglycemia (≥ 10 mmol/L) (OR 6.845, P = 0.023), LDH < 500 U/L ((OR 22.61, P = 0.001) and alcoholic etiology (OR 8.960, P = 0.041) were risk factors for SVT.
  
  
  CONCLUSIONS
  Alcohol intake, male gender and smoking should focus the physician's attention on the risk of SVT. When further associated with certain biological parameters, the physicians should consider therapeutic anticoagulation to prevent SVT.
authors.affiliation: Visceral and Endocrinal Surgery Department, University Hospital of Angers, Angers, France.|LUNAM, University of Angers, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Toqué
authors.affiliation: Visceral and Endocrinal Surgery Department, University Hospital of Angers, Angers, France.|LUNAM, University of Angers, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Hamy
authors.affiliation: LUNAM, University of Angers, France.|Department of Biostatistics and Methodology, University Hospital of Angers, France.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Hamel
authors.affiliation: Department of Hepato-gastroenterology, University Hospital of Angers, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Cesbron
authors.affiliation: LUNAM, University of Angers, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Hulo
authors.affiliation: LUNAM, University of Angers, France.
authors.forename: Solen
authors.initials: S
authors.lastname: Robert
authors.affiliation: Visceral and Endocrinal Surgery Department, University Hospital of Angers, Angers, France.|Department of Medical Imaging, University of Angers, Angers, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Aube
authors.affiliation: Visceral and Endocrinal Surgery Department, University Hospital of Angers, Angers, France.|LUNAM, University of Angers, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Lermite
authors.affiliation: Visceral and Endocrinal Surgery Department, University Hospital of Angers, Angers, France.|LUNAM, University of Angers, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Venara
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D015994:Incidence; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008642:Mesenteric Veins; D008875:Middle Aged; D015999:Multivariate Analysis; D010195:Pancreatitis / Q000097:blood / Q000150:complications*; D011169:Portal Vein; D011517:Prothrombin Time; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013162:Splenic Vein; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology*
chemical_list: D007770:L-Lactate Dehydrogenase
keywords: pancreatitis; risk factor; splanchnic vein; thrombosis