title: Antioxidant properties of HDL.
abstract: High-density lipoprotein (HDL) provides a pathway for the passage of lipid peroxides and lysophospholipids to the liver via hepatic scavenger receptors. Perhaps more importantly, HDL actually metabolizes lipid hydroperoxides preventing their accumulation on low-density lipoprotein (LDL), thus impeding its atherogenic structural modification. A number of candidates have been suggested to be responsible for HDL's antioxidant function, with paraoxonase-1 (PON1) perhaps the most prominent. Here we review the evidence for HDL anti-oxidative function and the potential contributions of apolipoproteins, lipid transfer proteins, paraoxonases and other enzymes associated with HDL.
authors.affiliation: Cardiovascular Research Group, Core Technology Facility, University of Manchester Manchester, UK ; Cardiovascular Trials Unit, Central Manchester University Hospitals NHS Foundation Trust Manchester, UK.
authors.forename: Handrean
authors.initials: H
authors.lastname: Soran
authors.affiliation: Cardiovascular Research Group, Core Technology Facility, University of Manchester Manchester, UK ; Cardiovascular Trials Unit, Central Manchester University Hospitals NHS Foundation Trust Manchester, UK.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Schofield
authors.affiliation: Cardiovascular Research Group, Core Technology Facility, University of Manchester Manchester, UK.
authors.forename: Paul N
authors.initials: PN
authors.lastname: Durrington
keywords: apolipoprotein A1; glycated low-density lipoprotein; high-density lipoprotein; oxidized low-density lipoprotein; paraoxonase 1