title: [Serum levels of B7-H3 and IFN-γ in patients with hepatitis B and clinical implications].
abstract: OBJECTIVE
  To detect the serum levels of soluble B7-H3 (sB7-H3) and interferon γ (IFN-γ) in patients with hepatitis B and related clinical implications.
  
  
  METHODS
  The levels of sB7-H3 and IFN-γ were detected by ELISA in 87 cases of hepatitis B including 16 cases of acute hepatitis, 25 cases of chronic moderate to severe hepatitis, 24 cases of liver cirrhosis, 22 cases of decompensated cirrhosis, and 24 healthy subjects. Their correlations with the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), α-fetoprotein (AFP), white blood cells (WBCs), hepatitis virus B (HBV) DNA were analyzed statistically.
  
  
  RESULTS
  The serum levels of sB7-H3 and IFN-γ in patients with hepatitis B were (202.17 ± 58.14) ng/mL and (3436.11 ± 1605.01) pg/mL, respectively, which were significantly higher than those in the healthy subjects. SB7-H3 was closely related to IFN-γ. AST, ALT, AFP, WBCs, and HBV DNA had no correlations with sB7-H3 and IFN-γ. SB7-H3 was the highest in the patients with acute hepatitis, while IFN-γ was the highest in the patients with chronic hepatitis B.
  
  
  CONCLUSIONS
  The levels of sB7-H3 and IFN-γ in the patients with hepatitis B are higher than those in the healthy subjects. Continuous monitoring of serum sB7-H3 and IFN-γ may helpful in predicting disease outcomes for patients with hepatitis B.
authors.affiliation: Department of Clinical Laboratory, First People's Hospital of Zhaoqing City, Zhaoqing 526020, China.
authors.forename: Chengde
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, First People's Hospital of Zhaoqing City, Zhaoqing 526020, China.
authors.forename: Jianmei
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Clinical Laboratory, First People's Hospital of Zhaoqing City, Zhaoqing 526020, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Clinical Laboratory, First People's Hospital of Zhaoqing City, Zhaoqing 526020, China.
authors.forename: Xueji
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Gastroenterology, First People's Hospital of Zhaoqing City, Zhaoqing 526020, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D060887:B7 Antigens / Q000097:blood*; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D060887:B7 Antigens; C423237:CD276 protein, human; D007371:Interferon-gamma