title: Expression of Aquaporin-6 in Rat Retinal Ganglion Cells.
abstract: Several aquaporins (AQPs) have been identified to be present in the eyes, and it has been suggested that they are involved in the movement of water and small solutes. AQP6, which has low water permeability and transports mainly anions, was recently discovered in the eyes. In the present study, we investigate the localization of AQP6 in the rat retina and show that AQP6 is selectively localized to the ganglion cell layer and the outer plexiform layer. Along with the gradual decrease in retinal ganglion cells after a crushing injury of optic nerve, immunofluorescence signals of AQP6 gradually decreased. Confocal microscope images confirmed AQP6 expression in retinal ganglion cells and Müller cells in vitro. Therefore, AQP6 might participate in water and anion transport in these cells.
authors.affiliation: Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 420-767, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Jang
authors.affiliation: Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 420-767, Korea.
authors.forename: Eung Suk
authors.initials: ES
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 420-767, Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Ohn
authors.affiliation: Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 420-767, Korea. tkpark@schmc.ac.kr.|Laboratory for Translational Research on Retinal and Macular Degeneration, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. tkpark@schmc.ac.kr.
authors.forename: Tae Kwann
authors.initials: TK
authors.lastname: Park
mesh_terms: D000818:Animals; D051403:Aquaporin 6 / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D063928:Ependymoglial Cells / Q000378:metabolism*; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism*
chemical_list: C496043:Aqp6 protein, rat; D051403:Aquaporin 6
keywords: Aquaporin-6; Ganglion cells; Müller cells; Rat; Retina