title: Novel Dammarane-Type Triterpene Saponins from Panax ginseng Root.
abstract: Four phytochemical constituents were isolated from Panax ginseng root by repeated column chromatography (CC), medium pressure liquid chromatography (MPLC), high-speed counter current chromatography (HSCCC), and semi-preparative HPLC. Their structures were elucidated as the dammarane-type triterpene saponins ginsenoside-Rg18 (1), 6-acetyl ginsenoside-Rg3 (2), ginsenoside-Rs11 (3), and ginsenoside-Re7 (4) based on spectral data. Compounds 1-4 from P. ginseng root were new compounds from nature. They showed good hydroxyl radical scavenging activity and anti-bacterial activity against Escherichia coli and Staphylococcus aureus. However, they did not show any anti-inflammatory activity. In addition, they inhibited the growth of adenocarcinoma gastric stomach cells. Among them, ginsenoside-Rs11 (3) showed the best anti-oxidative, anti-bacterial, and anti-cancer activities.
authors.affiliation: Department of Integrative Plant Science, Chung-Ang University.
authors.forename: Dong Gu
authors.initials: DG
authors.lastname: Lee
authors.forename: Ah Young
authors.initials: AY
authors.lastname: Lee
authors.forename: Kyung-Tack
authors.initials: KT
authors.lastname: Kim
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Cho
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy; D036145:Ginsenosides / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D005894:Panax / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D013274:Stomach Neoplasms / Q000188:drug therapy; D014315:Triterpenes / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D000097669:Dammaranes
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D036145:Ginsenosides; D014315:Triterpenes; D000097669:Dammaranes