title: Osthole promotes neuronal differentiation and inhibits apoptosis via Wnt/β-catenin signaling in an Alzheimer's disease model.
abstract: Neurogenesis is the process by which neural stem cells (NSCs) proliferate and differentiate into neurons. This is diminished in several neurodegenerative disorders such as Alzheimer's disease (AD), which is characterized by the deposition of amyloid (A)β peptides and neuronal loss. Stimulating NSCs to replace lost neurons is therefore a promising approach for AD treatment. Our previous study demonstrated that osthole modulates NSC proliferation and differentiation, and may reduce Aβ protein expression in nerve cells. Here we investigated the mechanism underlying the effects of osthole on NSCs. We found that osthole enhances NSC proliferation and neuronal differentiation while suppressing apoptosis, effects that were exerted via activation of Wnt/β-catenin signaling. These results provide evidence that osthole can potentially be used as a therapeutic agent in the treatment of AD and other neurodegenerative disorders.
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine; Dalian 116600, China.
authors.forename: Yingjia
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Interventional Therapy, Dalian Municipal Central Hospital, Dalian 116033, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Medical College of Dalian University, Dalian 116600, Liaoning, China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Liang
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine; Dalian 116600, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Kong
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine; Dalian 116600, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine; Dalian 116600, China.
authors.forename: Shaoheng
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine; Dalian 116600, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Tao
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine; Dalian 116600, China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Yan
authors.affiliation: School of Pharmacy, Liaoning University of Traditional Chinese Medicine; Dalian 116600, China. Electronic address: jingxianyang@yahoo.com.
authors.forename: Jingxian
authors.initials: J
authors.lastname: Yang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003374:Coumarins / Q000494:pharmacology*; D004195:Disease Models, Animal; D051379:Mice; D008810:Mice, Inbred C57BL; D058953:Neural Stem Cells / Q000187:drug effects / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000187:drug effects*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D003374:Coumarins; D051176:beta Catenin; C046627:osthol
keywords: Alzheimer's disease; Differentiation; Neural stem cells; Neurons; Osthole; Proliferation; Wnt/β-catenin signaling