title: Treatment of Gastrin-Secreting Tumor With Sustained-Release Octreotide Acetate in a Dog.
abstract: An 8 yr old, intact male Shiba Inu was presented with loose stool, polydipsia, hematuria, vomiting, and anorexia. On abdominal ultrasonography, numerous nodules were detected in the hepatic parenchyma distributed diffusely throughout all lobes. Excisional biopsy of one of the nodules was performed via exploratory laparotomy. A histopathological diagnosis of the lesion was carcinoid, and the tumor cells stained positive to chromogranin A and gastrin. The serum gastrin level of the dog was 45,613 pg/mL (reference range: 160-284). In addition to medical treatment with omeprazole(c) and famotidine(e), suppression of gastrin secretion was attempted with octreotide acetate. A test dose of octreotide acetate significantly decreased the serum gastrin level to approximately one third of the baseline in 2 hr and the effect lasted approximately for 6 hr. On day 21, treatment with sustained-release formulation of octreotide acetate(a) (5 mg intramuscular, q 4 wk) was initiated. The serum gastrin concentration gradually decreased over 32 days and then progressively increased in parallel with the progression of the hepatic nodules. The dog gradually developed recurrence of initial clinical signs, and was lost to follow-up on day 510.
authors.affiliation: Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.
authors.forename: Sangho
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hosoya
authors.affiliation: Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takagi
authors.affiliation: Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okumura
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D015738:Famotidine / Q000627:therapeutic use; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy / Q000662:veterinary*; D008297:Male; D015282:Octreotide / Q000008:administration & dosage / Q000627:therapeutic use*; D009853:Omeprazole / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D018931:Antineoplastic Agents, Hormonal; D003692:Delayed-Action Preparations; D005755:Gastrins; D015738:Famotidine; D009853:Omeprazole; D015282:Octreotide