title: TRIBBLES: A Twist in the Pseudokinase Tail.
abstract: TRIB1, a homolog of Drosophila Tribbles, regulates the stability of transcription factors through physical interaction with the ubiquitin E3 ligase COP1. In this issue of Structure, Murphy et al. (2015) report the first X-ray analysis of the TRIB1 pseudokinase domain and its C-terminal COP1-binding extension.
authors.affiliation: Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK. Electronic address: patrick.eyers@liverpool.ac.uk.
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Eyers
mesh_terms: D000818:Animals; D047908:Intracellular Signaling Peptides and Proteins; D008958:Models, Molecular; D011485:Protein Binding; D014157:Transcription Factors / Q000737:chemistry; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D014157:Transcription Factors; D044767:Ubiquitin-Protein Ligases