title: Haploidentical Bone Marrow Transplantation With Clofarabine and Busulfan Conditioning for a Child With Multiple Recurrent Acute Lymphoblastic Leukemia.
abstract: Outcome of children with acute lymphoblastic leukemia (ALL) has improved over the years, but not for those with multiple recurrences because of high therapy resistance and heavily pretreated history that potentially cause physical damages. We describe the case of an 11-year-old boy with a third relapse of ALL and a history of 2 allogeneic bone marrow transplantations. He was successfully treated with clofarabine combination chemotherapy and achieved a fourth remission at 16 months following haploidentical bone marrow transplantation with conditioning regimen of clofarabine and busulfan. Clofarabine/busulfan conditioning might be a preferable option for children with multiple recurrent ALL, and warrants further investigation.
authors.affiliation: Departments of *Pediatrics ‡Transfusion Medicine §Pharmacy, Tokyo Medical and Dental University (TMDU) ∥Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo †Department of Pediatrics, Uwajima City Hospital, Uwajima, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Aoki
authors.forename: Reiji
authors.initials: R
authors.lastname: Miyawaki
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Imai
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takagi
authors.forename: Michiko
authors.initials: M
authors.lastname: Kajiwara
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Ishiwata
authors.forename: Masato
authors.initials: M
authors.lastname: Yasuhara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Morio
authors.forename: Shuki
authors.initials: S
authors.lastname: Mizutani
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tomizawa
mesh_terms: D000227:Adenine Nucleotides / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001087:Arabinonucleosides / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000379:methods*; D002066:Busulfan / Q000627:therapeutic use; D002675:Child, Preschool; D000077866:Clofarabine; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods
chemical_list: D000227:Adenine Nucleotides; D000964:Antimetabolites, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D001087:Arabinonucleosides; D000077866:Clofarabine; D002066:Busulfan