title: Neuronal oscillations: A physiological correlate for targeting mitochondrial dysfunction in neurodegenerative diseases?
abstract: Increasingly in the realm of neurological disorders, particularly those involving neurodegeneration, mitochondrial dysfunction is emerging at the core of their pathogenic processes. Most of these diseases still lack effective treatment and are hampered by a shortfall in the development of novel medicines. Clearly new targets that translate well to the clinic are required. Physiological parameters in the form of neuronal network activity are increasingly being used as a therapeutic screening approach in drug development and disorders with mitochondrial dysfunction generally display neuronal network activity disturbance. However research directly linking the disturbances in neuronal network activity with mitochondrial dysfunction is only just starting to emerge. This review will summarize the breadth of knowledge linking neuronal network activity to mitochondrial dysfunction in neurodegenerative diseases and suggest potential avenues for exploration in respect to future drug development.
authors.affiliation: Institute of Neuroscience, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Felix
authors.initials: F
authors.lastname: Chan
authors.affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
authors.forename: Nichola Z
authors.initials: NZ
authors.lastname: Lax
authors.affiliation: Neural Pathways DPU, GSK, 11 Biopolis Way, 138667, Singapore.
authors.forename: Ceri H
authors.initials: CH
authors.lastname: Davies
authors.affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
authors.forename: Douglass M
authors.initials: DM
authors.lastname: Turnbull
authors.affiliation: Institute of Neuroscience, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, UK. Electronic address: mark.cunningham@ncl.ac.uk.
authors.forename: Mark O
authors.initials: MO
authors.lastname: Cunningham
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology*; D028361:Mitochondrial Diseases / Q000188:drug therapy / Q000503:physiopathology*; D009415:Nerve Net / Q000187:drug effects / Q000503:physiopathology*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000503:physiopathology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*
keywords: Biomarker; Mitochondrial dysfunction; Neurodegenerative diseases; Neuronal oscillation; Physiological correlate