title: Predictors of limph node metastasis in endometrial cancer.
abstract: BACKGROUND
  Endometrial cancer is the most common gynecologic malignancy in developed countries. The adequate surgical staging proposed by FIGO (International Federation for Gynaecology and Obstetrics) advocates lymphadenectomy; however, it does not establish the indications, the type and the extent of lymphadenectomy, thus generating multiple controversies.
  
  
  METHODS
  Retrospective, analytical study of patients treated surgically for endometrial adenocarcinoma in the Oncological Institute "Prof. Dr. Ion Chiricuţă" Cluj-Napoca (IOCN) between January 2008 and December 2012 - 709 cases eligible for the study.
  
  
  RESULTS
  206 pelvic and/or paraaortic lymphadenectomies were performed, the average number of excised lymph nodes being 15.6. Overall in 4.4% of patients the lymph nodes were affected by metastases. The presence of each risk factor analysed was statistically significantly associated with lymph node metastasis (p<0.05). Age above 55 years was statistically significantly associated (p<0.05) with the presence of negative prognostic factors in the study.
  
  
  CONCLUSIONS
  The analysed histopathological and clinical prognostic factors were statistically significantly associated with lymphatic dissemination in endometrial cancer. We recommend treating endometrial cancer in tertiary centres by surgeons or gynaecologists-oncologists with experience in extensive peritoneal and retroperitoneal surgery.
authors.affiliation: "Ion Chiricuta" Oncological Institute Cluj Napoca ; "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj Napoca, Oncology Department.
authors.forename: Florin Laurentiu
authors.initials: FL
authors.lastname: Ignat
authors.affiliation: "Ion Chiricuta" Oncological Institute Cluj Napoca ; "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj Napoca, Oncology Department.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Irimie
authors.affiliation: "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj Napoca, Oncology Department.
authors.forename: Nicolae
authors.initials: N
authors.lastname: Costin
authors.affiliation: "Ion Chiricuta" Oncological Institute Cluj Napoca ; "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj Napoca, Oncology Department.
authors.forename: Patriciu
authors.initials: P
authors.lastname: Achimas-Cadariu
authors.affiliation: "Ion Chiricuta" Oncological Institute Cluj Napoca.
authors.forename: Ioan Cosmin
authors.initials: IC
authors.lastname: Lisencu
keywords: endometrial cancer; lymphadenectomy; prognosis