title: Protective effect of ellagic acid on oxidative stress and antioxidant status in Cyprinus carpio during malathion exposure.
abstract: This study aims to determine protective efficiency of ellagic acid (EA) on malathion toxicity in carp. The fish were exposed to two sublethal concentrations of malathion (0.5 and 1 mg/L), and EA (100 mg per kg of fish weight) was simultaneously administered for 14 days. Malondialdehyde (MDA) level and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH&mdash;Px), and glutathione&mdash;S&mdash;transferase (GST) activities were evaluated in liver, kidney and gills, which were collected at the end of the experiment. In conclusion, the findings of this study demonstrated that malathion caused oxidative stress and negative alterations on the antioxidant enzyme activities of the fish. However, this toxic effect was neutralised by the administration of EA. Thus, the present results suggest that simultaneous treatment with EA (100 mg per kg of fish weight) may alleviate malathion&mdash;induced oxidative stress.
authors.affiliation: Firat University College of Keban, Fisheries Programme Elazig Turkey.
authors.forename: M Ş
authors.initials: MŞ
authors.lastname: Ural
authors.affiliation: Firat University Fisheries Faculty, Department of Aquaculture and Fish Diseases Elazig Turkey meyonar&commat;gmail.com.
authors.forename: M E
authors.initials: ME
authors.lastname: Yonar
authors.affiliation: Firat University Fisheries Faculty, Department of Aquaculture and Fish Diseases Elazig Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Mişe Yonar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002347:Carps / Q000502:physiology*; D002374:Catalase / Q000378:metabolism; D004610:Ellagic Acid / Q000494:pharmacology*; D005880:Gills / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008294:Malathion / Q000633:toxicity*; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D007306:Insecticides; D004610:Ellagic Acid; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione; D008294:Malathion