title: [The efficacy of sulpiride in patients with anxiety disorders depending on the serum serotonin concentrations].
abstract: OBJECTIVE
  The efficacy of sulpiride in patients with anxiety disorders depending on the serum serotonin concentrations was evaluated.
  
  
  METHODS
  We examined 132 patients with anxiety disorders. The higher levels of serotonin were found in 81 (61.3%) of patients, normal levels in 24 (25.8%) and lower levels in 27 (20.5%). Sulpiride was used in doses from 50 to 400 mg. Average treatment duration was >90 days.
  
  
  RESULTS
  The positive effect of sulpiride monotherapy was identified in patients with higher and normal levels of serotonin. No clinical effect of sulpiride was noted in patients with lower serotonin concentrations.
  
  
  CONCLUSIONS
  The efficacy of sulpiride depends on serum concentrations of serotonin. It can be assumed that serotonin concentration is a marker of sulpiride treatment efficacy in patients with anxiety disorders.
authors.affiliation: Scientific Centre of Personalized Psychiatry, Ltd, Moscow.
authors.forename: V B
authors.initials: VB
authors.lastname: Vil'yanov
authors.affiliation: Scientific Centre of Personalized Psychiatry, Ltd, Moscow.
authors.forename: S A
authors.initials: SA
authors.lastname: Kremenitskaya
authors.affiliation: Scientific Centre of Personalized Psychiatry, Ltd, Moscow.
authors.forename: N V
authors.initials: NV
authors.lastname: Solov'eva
mesh_terms: D000293:Adolescent; D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000097:blood* / Q000188:drug therapy*; D015415:Biomarkers / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood*; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D013469:Sulpiride / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018687:Antidepressive Agents, Second-Generation; D015415:Biomarkers; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors; D012701:Serotonin; D013469:Sulpiride