title: Metabolic roles of endocrine fibroblast growth factors.
abstract: Considerable effort is currently being devoted to understanding the physiological and pharmacological action of the endocrine fibroblast growth factors (FGFs). These three proteins (FGF15/19, FGF21 and FGF23) act in a tissue-specific manner through a membrane-complex consisting of an FGF-receptor and α/βKlotho. FGF15/19 is produced in the intestine and regulates postprandial liver metabolism and gallbladder filling. FGF21 is largely liver-derived and co-ordinates adaptive changes in response to nutritional and physiological stresses. FGF23 signals from the bone to the kidney to maintain phosphate homeostasis. In pharmacological settings, FGF15/19, FGF21, and the prototypical FGF1, potentially represent novel treatments for obesity and diabetes. This review summarises the recent advances in our understanding of the biology of these important metabolic regulators.
authors.affiliation: Division of Diabetes Endocrinology and Metabolism, Hammersmith Hospital Campus, Imperial College, London W12 0NN, UK.
authors.forename: Isabel
authors.initials: I
authors.lastname: Fernandes-Freitas
authors.affiliation: Division of Diabetes Endocrinology and Metabolism, Hammersmith Hospital Campus, Imperial College, London W12 0NN, UK. Electronic address: bryn.owen05@imperial.ac.uk.
authors.forename: Bryn M
authors.initials: BM
authors.lastname: Owen
mesh_terms: D000818:Animals; D016220:Fibroblast Growth Factor 1 / Q000378:metabolism* / Q000494:pharmacology; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism* / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D008660:Metabolism / Q000187:drug effects; D008954:Models, Biological
chemical_list: C117476:FGF19 protein, human; C000717427:FGF23 protein, human; C414620:fibroblast growth factor 21; D016220:Fibroblast Growth Factor 1; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23