title: ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases.
abstract: Chronic musculoskeletal pain is debilitating and affects ∼ 20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa.
authors.forename: Ramy E
authors.initials: RE
authors.lastname: Abdelhamid
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa kathleen-sluka@uiowa.edu.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Sluka
mesh_terms: D062565:Acid Sensing Ion Channels / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018482:Muscle, Skeletal / Q000294:innervation / Q000378:metabolism*; D059352:Musculoskeletal Pain / Q000378:metabolism* / Q000503:physiopathology; D009220:Myositis / Q000378:metabolism* / Q000503:physiopathology; D059225:Nociception; D017288:Pain Threshold; D015398:Signal Transduction
chemical_list: D062565:Acid Sensing Ion Channels