title: Cyclodextrin-based Polymeric Nanoparticles as Efficient Carriers for Anticancer Drugs.
abstract: Among the difficulties encountered in the treatment of cancer are the physico-chemical properties of the chemotherapeutic agents; in particular low water solubility and low stability, resulting in poor efficacy. Due to their capability to form molecular inclusions with apolar molecules (or part of them) cyclodextrins constitute a powerful tool to prepare more efficient chemotherapeutic delivery systems such as nanoparticles. This review focuses on polymeric nanoparticles for cancer therapy prepared from either cyclodextrin molecules, or polymer and cyclodextrins.
authors.affiliation: Galien Institute, UMR CNRS 8612, Faculty of Pharmacy, University Paris-South, 5 rue Jean Baptiste Clément, 92290 Chatenay Malabry, France. dominique.duchene@u-psud.fr.
authors.forename: Dominique
authors.initials: D
authors.lastname: Duchene
authors.forename: Roberta
authors.initials: R
authors.lastname: Cavalli
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Gref
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D011108:Polymers