title: A New Way to Accelerate the Distraction of the Transpalatal Suture in Growing Dogs Using Recombinant Human Bone Morphogenetic Protein-2.
abstract: The purpose of this study was to evaluate the administration of recombinant human bone morphogenetic protein-2 (rhBMP-2) on trans-sutural distraction osteogenesis (TSDO) of the transverse palatal suture in growing dogs.
  
  
  
  A total of 36 growing dogs were used in this study. The experimental animals were treated with different elastic force and rhBMP-2. The bone regeneration was determined with X-ray, histology, and clinical evaluation. The computed values underwent statistical analyses using analysis of variance.
  
  
  
  The maxillary complex was most noticeably advanced with an applied elastic force of 600 g (22.4 ± 5.0 mm) and 800 g + rhBMP-2 (24 ± 5.1 mm). Immunohistochemical staining showed that the expression of bone morphogenetic protein-2 and bone morphogenetic protein-4 varied with different elastic force. These changes were statistically significant when 600 g and 800 g + rhBMP-2 were applied within 2 weeks of distraction when compared with controls (P < .05).
  
  
  
  The results of this study suggest that TSDO in the growing dog should be safe and well tolerated when inducing bony lengthening of the maxilla. rhBMP-2 plays an important role in bone regeneration using TSDO.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Guiran
authors.forename: Wang
authors.initials: W
authors.lastname: Ying
authors.forename: Wang
authors.initials: W
authors.lastname: Guijun
authors.forename: Wang
authors.initials: W
authors.lastname: Chengyue
authors.forename: Yao
authors.initials: Y
authors.lastname: Yusheng
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology*; D003393:Cranial Sutures / Q000601:surgery*; D004285:Dogs; D007150:Immunohistochemistry; D019857:Osteogenesis, Distraction / Q000379:methods*; D010155:Palatal Expansion Technique; D011994:Recombinant Proteins / Q000494:pharmacology; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
chemical_list: D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2
keywords: bone regeneration; recombinant human bone morphogenetic protein-2; trans-sutural distraction osteogenesis