title: Tribbles in inflammation.
abstract: Inflammation is part of the physiological innate immune response to invading pathogens and tissue injury. However, unresolved inflammation leads to human disease. The tribbles (TRIB) family of pseudokinase proteins has been shown to modulate key inflammatory signalling pathways, including the MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinase) networks. This review summarizes our current knowledge on TRIBs in the context of inflammation, both at the level of molecular mechanisms and in disease development.
authors.affiliation: Department of Cardiovascular Science, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, U.K.
authors.forename: Jessica
authors.initials: J
authors.lastname: Johnston
authors.affiliation: Academic Unit of Reproductive and Developmental Medicine, Department of Human Metabolism, Medical School, University of Sheffield, Level 4, The Jessop Wing, Tree Root Walk, Sheffield S 10 2SF, U.K.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Basatvat
authors.affiliation: Department of Cardiovascular Science, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, U.K.
authors.forename: Zabran
authors.initials: Z
authors.lastname: Ilyas
authors.affiliation: Department of Cardiovascular Science, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, U.K.
authors.forename: Sheila
authors.initials: S
authors.lastname: Francis
authors.affiliation: Department of Cardiovascular Science, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, U.K. e.kiss-toth@sheffield.ac.uk.
authors.forename: Endre
authors.initials: E
authors.lastname: Kiss-Toth
mesh_terms: D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; D012097:Repressor Proteins; C493170:TRIB1 protein, human; C474831:TRIB3 protein, human; D017346:Protein Serine-Threonine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C489044:TRIB2 protein, human
keywords: chronic inflammation; disease; mitogen-activated protein kinase (MAPK); tribbles