title: Redox-Triggered Gatekeeper-Enveloped Starlike Hollow Silica Nanoparticles for Intelligent Delivery Systems.
abstract: The design and development of multifunctional carriers for drug delivery based on hollow nanoparticles (HNPs) have attracted intense interests. Ordinary spherical HNPs are demonstrated to be promising candidates. However, the application of HNPs with special morphologies has rarely been reported. HNPs with sharp horns are expected to own higher endocytosis efficiencies than spherical counterparts. In this work, novel starlike hollow silica nanoparticles (SHNPs) with different sizes are proposed as platforms for the fabrication of redox-triggered multifunctional systems for synergy of gene therapy and chemotherapy. The CD-PGEA gene vectors (consisting of β-CD cores and ethanolamine-functionalized poly(glycidyl methacrylate) (denoted BUCT-PGEA) arms) are introduced ingeniously onto the surfaces of SHNPs with plentiful disulfide bond-linked adamantine guests. The resulting supramolecular assemblies (SHNP-PGEAs) possess redox-responsive gatekeepers for loaded drugs in the cavities of SHNPs. Meanwhile, they also demonstrate excellent performances to deliver genes. The gene transfection efficiencies, controlled drug release behaviors, and synergistic antitumor effect of hollow silica-based carriers with different morphologies are investigated in detail. Compared with ordinary spherical HNP-based counterparts, SHNP-PGEA carriers with six sharp horns are proven to be superior gene vectors and possess better efficacy for cellular uptake and antitumor effects. The present multifunctional carriers based on SHNPs will have promising applications in drug/gene codelivery and cancer treatment.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, USA.
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Ji
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
authors.forename: Fu-Jian
authors.initials: FJ
authors.lastname: Xu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D019556:COS Cells; D002166:Camptothecin / Q000494:pharmacology; D016923:Cell Death; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D043525:Cytosine Deaminase / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D004705:Endocytosis / Q000187:drug effects; D004926:Escherichia coli / Q000201:enzymology; D005437:Flucytosine / Q000494:pharmacology; D005453:Fluorescence; D041722:Genes, Transgenic, Suicide; D015316:Genetic Therapy; D049452:Green Fluorescent Proteins / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D008156:Luciferases / Q000235:genetics; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010316:Particle Size; D010957:Plasmids / Q000378:metabolism; D011109:Polymethacrylic Acids / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D000970:Antineoplastic Agents; D011109:Polymethacrylic Acids; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; C042535:polyglycidyl methacrylate; D012822:Silicon Dioxide; D004247:DNA; D005437:Flucytosine; D008156:Luciferases; D043525:Cytosine Deaminase; D002166:Camptothecin
keywords: hollow nanoparticle; morphology; multifunctional; redox-responsive; supramolecular