title: A Simple Low-dose X-ray CT Simulation from High-dose Scan.
abstract: Low-dose X-ray computed tomography (CT) simulation from high-dose scan is required in optimizing radiation dose to patients. In this study, we propose a simple low-dose CT simulation strategy in sinogram domain using the raw data from high-dose scan. Specially, a relationship between the incident fluxes of low- and high- dose scans is first determined according to the repeated projection measurements and analysis. Second, the incident flux level of the simulated low-dose scan is generated by properly scaling the incident flux level of high-dose scan via the determined relationship in the first step. Third, the low-dose CT transmission data by energy integrating detection is simulated by adding a statistically independent Poisson noise distribution plus a statistically independent Gaussian noise distribution. Finally, a filtered back-projection (FBP) algorithm is implemented to reconstruct the resultant low-dose CT images. The present low-dose simulation strategy is verified on the simulations and real scans by comparing it with the existing low-dose CT simulation tool. Experimental results demonstrated that the present low-dose CT simulation strategy can generate accurate low-dose CT sinogram data from high-dose scan in terms of qualitative and quantitative measurements.
authors.affiliation: School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zeng
authors.affiliation: School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
authors.forename: Zhaoying
authors.initials: Z
authors.lastname: Bian
authors.affiliation: School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
authors.forename: Shanzhou
authors.initials: S
authors.lastname: Niu
authors.affiliation: School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Feng
authors.affiliation: Department of Radiology, State University of New York, Stony Brook, NY 11794, USA.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Liang
authors.affiliation: School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ma
keywords: X-ray CT; high-dose; low-dose; simulation