title: [STUDIES IN VITRO INHIBITION OF THE ANGIOTENSIN-CONVERTING ENZYME-I, HYPOTENSIVE AND ANTIHYPERTENSIVE EFFECTS OF PEPTIDE FRACTIONS OF V. UNGUICULATA].
abstract: Inhibition of angiotensin-converting enzyme I (ACE-I) in vitro and in vivo from peptide fractions by enzymatic hydrolysis of the Vigna unguiculata protein concentrate was evaluated. Hydrolysis was done with Pepsin-Pancreatin and Flavourzima in two separate systems. The resulting hidrolysates were ultrafiltrated to obtain fractions with different molecular weight. The fractions with better inhibition Flavourzima were size > 1 kDa (> 1 kDa-F) and < 1 kDa (< 1 kDa-F), with an IC50 of 1222.84 and 1098.6 μg/ml respectively. Pepsin-Pancreatin fraction.
authors.affiliation: Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida (Yucatán), México.. cguerrer@correo.uady.mx.
authors.forename: Trinidad
authors.initials: T
authors.lastname: Cú-Cañetas
authors.affiliation: Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida (Yucatán), México.. cguerrer@correo.uady.mx.
authors.forename: David
authors.initials: D
authors.lastname: Betancur Ancona
authors.affiliation: Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida (Yucatán), México.. cguerrer@correo.uady.mx.
authors.forename: Santiago
authors.initials: S
authors.lastname: Gallegos Tintoré
authors.affiliation: Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida (Yucatán), México.. cguerrer@correo.uady.mx.
authors.forename: Mukthar
authors.initials: M
authors.lastname: Sandoval Peraza
authors.affiliation: Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida (Yucatán), México.. cguerrer@correo.uady.mx.
authors.forename: Luis
authors.initials: L
authors.lastname: Chel Guerrero
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D006868:Hydrolysis; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010940:Plant Proteins / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010455:Peptides; D010940:Plant Proteins