title: The GNAQ in the haystack: intramedullary meningeal melanocytoma of intermediate grade at T9-10 in a 58-year-old woman.
abstract: Meningeal melanocytomas are rare tumors. They are derived from leptomeningeal melanocytes and predominantly occur along the spine and the posterior fossa. Here, the authors report a case of intramedullary melanocytoma of intermediate grade in a 58-year-old female patient who was initially misdiagnosed with malignant melanoma until mutational analyses of a panel of genes associated with melanotic tumors led to reclassification.
authors.affiliation: Departments of 1 Radiation Oncology.
authors.forename: Michael
authors.initials: M
authors.lastname: Hoffmann
authors.affiliation: Department of Neuropathology, Ruprecht-Karls-University Heidelberg, and Clinical Cooperation Unit Neuropathology, and DKTK, DKFZ, Heidelberg; and.
authors.forename: Christian
authors.initials: C
authors.lastname: Koelsche
authors.affiliation: Neurosurgery, and.
authors.forename: Marcel
authors.initials: M
authors.lastname: Seiz-Rosenhagen
authors.affiliation: Departments of 1 Radiation Oncology.
authors.forename: Sabine
authors.initials: S
authors.lastname: Mai
authors.affiliation: Departments of 1 Radiation Oncology.
authors.forename: Frank
authors.initials: F
authors.lastname: Lohr
authors.affiliation: Department of Neuropathology, Ruprecht-Karls-University Heidelberg, and Clinical Cooperation Unit Neuropathology, and DKTK, DKFZ, Heidelberg; and.
authors.forename: David
authors.initials: D
authors.lastname: Reuss
authors.affiliation: Departments of 1 Radiation Oncology.
authors.forename: Frederik
authors.initials: F
authors.lastname: Wenz
authors.affiliation: Dermatology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim;|Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Christoffer
authors.initials: C
authors.lastname: Gebhardt
authors.affiliation: Departments of 1 Radiation Oncology.
authors.forename: Frank A
authors.initials: FA
authors.lastname: Giordano
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000235:genetics*; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000473:pathology*; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D013904:Thoracic Vertebrae
chemical_list: C554061:GNAQ protein, human; D043802:GTP-Binding Protein alpha Subunits, Gq-G11
keywords: CNS tumors; GNAQ mutation; meningeal melanocytoma; oncology