title: The prevalence of HLA DQ2 and DQ8 in patients with celiac disease, in family and in general population.
abstract: BACKGROUND
  Celiac disease is an enteropathy characterized by gluten sensitivity and broad clinical aspect. Has a multifactorial cause and depends on genetic, immunological and environmental factors for its development. The genetic influence is given mostly by the human leukocyte antigens HLA DQ2 and DQ8.
  
  
  OBJECTIVE
  To evaluate the prevalence of human leukocyte antigens DQ2 and DQ8 in three different groups: patients with celiac disease, first-degree relatives and the general population.
  
  
  METHODS
  Retrospective analysis that evaluated serologic and endoscopic data of 74 patients with celiac disease and 109 non-celiac, which were subdivided into two subgroups: non-celiac who had first-degree relatives with celiac and non-celiac who did not. All patients underwent laboratory examination for screening genetic sensitivity given by HLA DQ2 and HLA DQ8 by.
  
  
  RESULTS
  The presence of HLA DQ2 and DQ8 was identified in 98,4% of 74 celiac patients, of which 79,7% had only HLA DQ2; 8,1% had only HLA DQ8 and 10,8% had both antigens histocompatibility. In the group of relatives of celiac patients, were included 29 patients; among them, 89,6% had HLA DQ2 and/or DQ8; 76% only the HLA DQ2, 10,3% only HLA DQ8 and 3,4% presented both human leukocyte antigens (HLA).
  
  
  CONCLUSIONS
  HLA DQ2/DQ8 was present in 98,4% of celiac patients; 89,6% relatives of celiac family and in 55,4% of people from the general population without family celiac.
authors.affiliation: School of Medicine, Faculdade Assis Gurgacz, Cascavel, PR, Brazil.
authors.forename: Lucila Arantes
authors.initials: LA
authors.lastname: Cecilio
authors.affiliation: aff1, Brazil.
authors.forename: Mauro W
authors.initials: MW
authors.lastname: Bonatto
mesh_terms: D002446:Celiac Disease / Q000097:blood* / Q000235:genetics; D006683:HLA-DQ Antigens / Q000097:blood* / Q000235:genetics; D006801:Humans; D012189:Retrospective Studies
chemical_list: D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; C109756:HLA-DQ8 antigen