title: Successful Engraftment and Durable Graft-versus-host Disease Control with Haploidentical Peripheral Blood and a Short-term Conditioning Regimen for Primary Graft Failure.
abstract: Primary graft failure occurred after cord blood transplantation for a patient with acute lymphoblastic leukemia. The second transplantation was performed using haploidentical peripheral blood. The conditioning regimen consisted of fludarabine (day -1; 30 mg/m(2)), cyclophosphamide (day -1; 2,000 mg/m(2)), and total body irradiation (day -1; 2 Gy). The immunosuppressants contained tacrolimus, prednisolone, and rabbit anti-thymocyte globulin (day -3 to -2; total dose: 3.75 mg/kg). The engraftment was confirmed on day 9. Both acute and chronic graft-versus-host disease were controllable. The present regimen appears to be suitable for immediate management, fast engraftment, and the durable control of complications.
authors.affiliation: Department of Hematology, Yokohama City University Medical Center, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tachibana
authors.forename: Eri
authors.initials: E
authors.lastname: Yamamoto
authors.forename: Rika
authors.initials: R
authors.lastname: Kawasaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Koharazawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishibashi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: Shin
authors.initials: S
authors.lastname: Fujisawa
mesh_terms: D006086:Graft vs Host Disease / Q000188:drug therapy*; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D016559:Tacrolimus / Q000008:administration & dosage; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D007166:Immunosuppressive Agents; D014740:Vidarabine; C024352:fludarabine; D008558:Melphalan; D016559:Tacrolimus