title: Chiral Sulfinamide Bisphosphine Catalysts: Design, Synthesis, and Application in Highly Enantioselective Intermolecular Cross-Rauhut-Currier Reactions.
abstract: A novel type of highly efficient chiral sulfinamide bisphosphine catalysts (Wei-Phos) were developed. These could be easily prepared from commercially available starting materials. Wei-Phos has shown good performance in the very challenging intermolecular cross-Rauhut-Currier reactions of vinyl ketones and 3-acyl acrylates or 2-ene-1,4-diones, leading to the R-C products in high yields with up to 99% ee under 2.5-5 mol% catalyst loading. The highly regio- and enantio-selective cross-Rauhut-Currier reactions of 2-ene-1,4-diones and vinyl ketone have yet reported so far.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 (P. R. China) http://faculty.ecnu.edu.cn/s/1811/main.jspy.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 (P. R. China) http://faculty.ecnu.edu.cn/s/1811/main.jspy.
authors.forename: Xiao
authors.initials: X
authors.lastname: Su
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 (P. R. China) http://faculty.ecnu.edu.cn/s/1811/main.jspy.
authors.forename: Mengna
authors.initials: M
authors.lastname: Tao
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 (P. R. China) http://faculty.ecnu.edu.cn/s/1811/main.jspy.
authors.forename: Chaoze
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 (P. R. China) http://faculty.ecnu.edu.cn/s/1811/main.jspy. qjzhao@smmu.edu.cn.|Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433 (P. R. China). qjzhao@smmu.edu.cn.
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 (P. R. China) http://faculty.ecnu.edu.cn/s/1811/main.jspy. jlzhang@chem.ecnu.edu.cn.
authors.forename: Junliang
authors.initials: J
authors.lastname: Zhang
keywords: Rauhut-Currier reaction; alkenes; asymmetric catalysis; chiral sulfinamidephosphines; organocatalysis