title: [Radical surgery after successful chemotherapy in a case of primary small cell carcinoma of the liver].
abstract: A 52-year-old woman was admitted to our hospital with right upper quadrant pain with gallbladder wall thickening and multiple liver tumors. Endoscopic ultrasound-guided biopsy revealed small cell carcinomas of both the gallbladder and liver. After 10 cycles of chemotherapy with etoposide and cisplatin, marked shrinkage of the tumors was evident on computed tomography. The patient subsequently underwent hepatectomy and resection of the extrahepatic bile duct and gallbladder with curative intent. Although no viable tumor cells were found in the resected specimens, we confirmed phagocytosis of tumor cells killed by chemotherapy in the resected liver specimen. Therefore, we suspected that the patient had primary small cell carcinoma of the liver that had been successfully treated. This is a rare case of primary small cell carcinoma of the liver that showed pathological complete response to chemotherapy with etoposide and cisplatin.
authors.affiliation: Department of Gastroenterology, Okayama University Hospital.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tsutsumi
authors.forename: Hironari
authors.initials: H
authors.lastname: Kato
authors.forename: Hidenori
authors.initials: H
authors.lastname: Hata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakae
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uchida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tomoda
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Noma
authors.forename: Naoki
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Shigeru
authors.initials: S
authors.lastname: Horiguchi
authors.forename: Ryo
authors.initials: R
authors.lastname: Harada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yanai
authors.forename: Takahito
authors.initials: T
authors.lastname: Yagi
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D002945:Cisplatin