title: New Developments in the Genetics of Hypertension: What Should Clinicians Know?
abstract: It has long been known that genetic factors play a major role in determining an individual's propensity to hypertension. In recent years, there has been major progress towards realizing the goal of identifying the specific genetic factors that lead to alterations in blood pressure. Of particular note, new genes regulating renal sodium handling and aldosterone regulation have been discovered via the study of rare Mendelian disorders. Similarly, a number of large genome-wide association studies have been completed, which have added to our understanding as well. Here, recent progress in the genetics of hypertension will be reviewed, with an emphasis towards highlighting specific areas where clinical practice has already or will soon be affected.
authors.affiliation: Section of Nephrology, Department of Medicine, Yale University School of Medicine, 330 Cedar Street, PO Box 208029, New Haven, CT, 06520-8029, USA. david.geller@yale.edu.|West Haven VA Medical Center, West Haven, CT, 06516, USA. david.geller@yale.edu.
authors.forename: David S
authors.initials: DS
authors.lastname: Geller
mesh_terms: D002874:Chromosome Mapping; D004252:DNA Mutational Analysis; D019317:Evidence-Based Medicine; D008040:Genetic Linkage; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
keywords: Genetics; Genome-wide association studies; Hypertension; Hypertension with brachydactyly type E; Hypertension with hyperkalemia; Primary aldosteronism