title: The L-type voltage-dependent calcium channel long-term potentiation is higher in the dorsal compared with the ventral associational/commissural CA3 hippocampal synapses.
abstract: The diversification between dorsal (DH) and ventral (VH) hippocampus includes the different ability to support NMDA receptor-dependent long-term synaptic potentiation (LTP). In this study, we assessed the ability of associational/commissural connections in the CA3 hippocampal field to show NMDA receptor-independent LTP. We found that high-frequency stimulation under blockade of NMDA receptors induced greater LTP in DH (40.7±8.5%) than in VH (17.1±4.6%). The blocker of L-type voltage-dependent calcium channels (VDCC) nifedipine prevented the induction of LTP. We hypothesize that the different ability for VDCC-LTP between DH and VH might have important implications in the memory-related information processing performed by the circuits of the two hippocampal segments.
authors.affiliation: Laboratory of Physiology, Medical School, University of Patras, 26504 Rion, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Moschovos
authors.affiliation: Laboratory of Physiology, Medical School, University of Patras, 26504 Rion, Greece. Electronic address: cepapath@upatras.gr.
authors.forename: Costas
authors.initials: C
authors.lastname: Papatheodoropoulos
mesh_terms: D000818:Animals; D056654:CA3 Region, Hippocampal / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D020712:Fornix, Brain / Q000502:physiology*; D017774:Long-Term Potentiation; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013569:Synapses / Q000502:physiology*
chemical_list: D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D016194:Receptors, N-Methyl-D-Aspartate; D009543:Nifedipine
keywords: CA3; Dorsoventral; Facilitation; Hippocampus; Long-term potentiation; Memory; Septotemporal; Voltage-dependent calcium channel