title: A comparison of Wharton's jelly and cord blood as a source of mesenchymal stem cells for diabetes cell therapy.
abstract: OBJECTIVE
  In this study, we investigated the differences between mesenchymal stem cells (MSCs), isolated from umbilical cord blood (UCB-MSCs) and Wharton's jelly (WJ-MSCs) as sources of diabetes mellitus cell therapy.
  
  
  METHODS
  After isolation, both cell types were induced to differentiate into insulin producing cells, then the differentiated cells were assessed genetically and functionally. UCB-MSCs and WJ-MSCs were transplanted in the tail veins of streptozotocin-induced diabetic rats. Blood glucose levels were monitored post-transplantation.
  
  
  CONCLUSIONS
  Wharton's jelly was more homogeneous, can better differentiate into insulin producing cells in vitro and better control hyperglycemia in diabetic rats in vivo, as compared with UCB. These results indicate that WJ-MSCs represent a potential source of cells in the field of diabetes mellitus cell therapy.
authors.affiliation: Pharmacology & Toxicology Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt, 44971.
authors.forename: Rasha F
authors.initials: RF
authors.lastname: El-Demerdash
authors.affiliation: Pharmacology & Toxicology Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt, 44971.
authors.forename: Lamiaa N
authors.initials: LN
authors.lastname: Hammad
authors.affiliation: Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt, 11566.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Kamal
authors.affiliation: Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt, 11566.
authors.forename: Hala O
authors.initials: HO
authors.lastname: El Mesallamy
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000628:therapy; D005312:Fetal Blood / Q000166:cytology / Q000378:metabolism; D064593:Heterografts; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D059631:Wharton Jelly / Q000166:cytology / Q000378:metabolism
keywords: Wharton's jelly; cell banking; cell therapy; diabetes mellitus; mesenchymal stem cells; umbilical cord blood