title: Cellular Defense and Sensory Cell Survival Require Distinct Functions of ebi in Drosophila.
abstract: The innate immune response and stress-induced apoptosis are well-established signaling pathways related to cellular defense. NF-κB and AP-1 are redox-sensitive transcription factors that play important roles in those pathways. Here we show that Ebi, a Drosophila homolog of the mammalian co-repressor molecule transducin β-like 1 (TBL1), variously regulates the expression of specific genes that are targets of redox-sensitive transcription factors. In response to different stimuli, Ebi activated gene expression to support the acute immune response in fat bodies, whereas Ebi repressed genes that are involved in apoptosis in photoreceptor cells. Thus, Ebi seems to act as a regulatory switch for genes that are activated or repressed in response to different external stimuli. Our results offer clear in vivo evidence that the Ebi-containing co-repressor complex acts in a distinct manner to regulate transcription that is required for modulating the output of various processes during Drosophila development.
authors.affiliation: Animal Models of Aging Project Team, Center for Development of Advanced Medicine for Dementia (CAMD), National Center for Geriatrics and Gerontology (NCGG), Obu, Aichi, Japan.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Lim
authors.affiliation: Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Aichi, 464-8602, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Yagi
authors.affiliation: Animal Models of Aging Project Team, Center for Development of Advanced Medicine for Dementia (CAMD), National Center for Geriatrics and Gerontology (NCGG), Obu, Aichi, Japan.
authors.forename: Leo
authors.initials: L
authors.lastname: Tsuda
mesh_terms: D000818:Animals; D017209:Apoptosis; D018797:Cell Cycle Proteins / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000276:immunology*; D005216:Fat Body / Q000276:immunology*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D007113:Immunity, Innate; D010084:Oxidation-Reduction; D017956:Photoreceptor Cells, Invertebrate / Q000166:cytology; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; C119014:ebi protein, Drosophila; D019204:GTP-Binding Proteins