title: Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure.
abstract: We present our recent advancements in developing a viable manufacturing process for printed medicine. Our approach involves using a non-contact printing system that incorporates both piezoelectric- and solenoid valve-based inkjet printing technologies, to deliver both active and inactive pharmaceutical materials onto medical-graded orodispersible films. By using two complimentary inkjet technologies, we were able to dispense an extensive range of fluids, from aqueous drug solutions to viscous polymer coating materials. Essentially, we demonstrate printing of a wide range of formulations for patient-ready, orodispersible drug dosage forms, without the risk of drug degradation by ink heating and of substrate damages (by contact printing). In addition, our printing process has been optimized to ensure that the drug doses can be loaded onto the orally dissolvable films without introducing defects, such as holes or tears, while retaining a smooth surface texture that promotes patient adherence and allows for uniform post-coatings. Results show that our platform technology can address key issues in manufacturing orodispersible drug dosage forms and bring us closer to delivering personalized and precision medicine to targeted patient populations.
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria; University of Technology, Institute of Fluid Mechanics and Heat Transfer, Graz, Austria. Electronic address: carole.planchette@tugraz.at.
authors.forename: C
authors.initials: C
authors.lastname: Planchette
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Pichler
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Wimmer-Teubenbacher
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Gruber
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria; University of Technology, Institute of Process and Particle Technology, Graz, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Gruber-Woelfler
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Mohr
authors.affiliation: Karl-Franzens University, Institute of Pharmaceutical Sciences, Department Pharmaceutical Technology, Graz, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Tetyczka
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
authors.forename: W-K
authors.initials: WK
authors.lastname: Hsiao
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Paudel
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria; Karl-Franzens University, Institute of Pharmaceutical Sciences, Department Pharmaceutical Technology, Graz, Austria.
authors.forename: E
authors.initials: E
authors.lastname: Roblegg
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, Graz, Austria; University of Technology, Institute of Process and Particle Technology, Graz, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Khinast
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004304:Dosage Forms; D016503:Drug Delivery Systems / Q000379:methods; D005079:Excipients / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D019999:Pharmaceutical Solutions / Q000737:chemistry; D057285:Precision Medicine / Q000379:methods; D011327:Printing / Q000379:methods*; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods*; D014783:Viscosity
chemical_list: D004304:Dosage Forms; D005079:Excipients; D004364:Pharmaceutical Preparations; D019999:Pharmaceutical Solutions
keywords: Coating; Doses combination; Geriatric; Ink formulation; Inkjet printing; Nanosuspension; Orodispersible dosage form; Patient adherence; Pediatric; Personalized medicine; Precision medicine; Printed medicine