title: Simulation-Based Evaluation of the Performances of an Algorithm for Detecting Abnormal Disease-Related Features in Cattle Mortality Records.
abstract: We performed a simulation study to evaluate the performances of an anomaly detection algorithm considered in the frame of an automated surveillance system of cattle mortality. The method consisted in a combination of temporal regression and spatial cluster detection which allows identifying, for a given week, clusters of spatial units showing an excess of deaths in comparison with their own historical fluctuations. First, we simulated 1,000 outbreaks of a disease causing extra deaths in the French cattle population (about 200,000 herds and 20 million cattle) according to a model mimicking the spreading patterns of an infectious disease and injected these disease-related extra deaths in an authentic mortality dataset, spanning from January 2005 to January 2010. Second, we applied our algorithm on each of the 1,000 semi-synthetic datasets to identify clusters of spatial units showing an excess of deaths considering their own historical fluctuations. Third, we verified if the clusters identified by the algorithm did contain simulated extra deaths in order to evaluate the ability of the algorithm to identify unusual mortality clusters caused by an outbreak. Among the 1,000 simulations, the median duration of simulated outbreaks was 8 weeks, with a median number of 5,627 simulated deaths and 441 infected herds. Within the 12-week trial period, 73% of the simulated outbreaks were detected, with a median timeliness of 1 week, and a mean of 1.4 weeks. The proportion of outbreak weeks flagged by an alarm was 61% (i.e. sensitivity) whereas one in three alarms was a true alarm (i.e. positive predictive value). The performances of the detection algorithm were evaluated for alternative combination of epidemiologic parameters. The results of our study confirmed that in certain conditions automated algorithms could help identifying abnormal cattle mortality increases possibly related to unidentified health events.
authors.affiliation: Unité Epidémiologie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail-Laboratoire de Lyon, Lyon, France.|Unité Epidémiologie animale, UR346, INRA, St Genès Champanelle, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Perrin
authors.affiliation: Unité Epidémiologie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail-Laboratoire de Santé Animale, Maisons-Alfort, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Durand
authors.affiliation: Unité Epidémiologie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail-Laboratoire de Lyon, Lyon, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Gay
authors.affiliation: Unité Epidémiologie animale, UR346, INRA, St Genès Champanelle, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Ducrot
authors.affiliation: Unité Coordination et appui à la surveillance, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail-Laboratoire de Lyon, Lyon, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Hendrikx
authors.affiliation: Unité Epidémiologie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail-Laboratoire de Lyon, Lyon, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Calavas
authors.affiliation: Unité Epidémiologie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail-Laboratoire de Lyon, Lyon, France.
authors.forename: Viviane
authors.initials: V
authors.lastname: Hénaux
mesh_terms: D000465:Algorithms; D000818:Animals; D002417:Cattle; D003141:Communicable Diseases / Q000401:mortality* / Q000662:veterinary; D003198:Computer Simulation; D004196:Disease Outbreaks / Q000517:prevention & control* / Q000662:veterinary*; D058872:Epidemics / Q000706:statistics & numerical data*; D009026:Mortality / Q000639:trends*; D011159:Population Surveillance / Q000379:methods*