title: Pancreaticoduodenectomy with venous reconstruction using cold-stored vein allografts: long-term results of a single center experience.
abstract: BACKGROUND
  The use of cadaveric vein allografts was first described by our group as a feasible option for venous reconstruction. The aim of this study was to report long-term results of this innovative technique.
  
  
  METHODS
  Cold-stored veins harvested from donor cadavers were used as homologous grafts for venous reconstruction after vascular resection during pancreaticoduodenectomy. Surgical technique included patch closure or segmental interposition. Graft patency was assessed by computed tomography postoperatively and during follow-up. Postoperative morbidity and mortality were also analyzed.
  
  
  RESULTS
  Eleven patients underwent venous resection and reconstruction by using fresh vein allografts for patch closure in four cases, conduit interposition in six cases and a Y-shaped graft interposition in one case. Median clamping time, operative time and estimated blood loss were 30 min, 6.6 h, and 337 ml, respectively. One patient, who had preoperative SMV thrombus, developed early portal vein thrombosis and died. Among the remaining 10 patients, there were no cases of graft thrombosis or stenosis during active follow-up (median 9, range 1-23, months).
  
  
  CONCLUSIONS
  Our experience with cold-stored vein allografts suggests that this technique is a useful option for treating major vascular resections during pancreaticoduodenectomy with good results on follow-up.
authors.affiliation: Division of General Surgery and Organ Transplantation, San Camillo-Forlanini Hospital, 87 Circonvallazione Gianicolense, 00152 Rome, Italy.
authors.forename: Roberto L
authors.initials: RL
authors.lastname: Meniconi
authors.affiliation: Division of General Surgery and Organ Transplantation, San Camillo-Forlanini Hospital, 87 Circonvallazione Gianicolense, 00152 Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Santoro
authors.affiliation: Division of General Surgery and Organ Transplantation, San Camillo-Forlanini Hospital, 87 Circonvallazione Gianicolense, 00152 Rome, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Guglielmo
authors.affiliation: Division of General Surgery and Organ Transplantation, San Camillo-Forlanini Hospital, 87 Circonvallazione Gianicolense, 00152 Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vennarecci
authors.affiliation: Division of General Surgery and Organ Transplantation, San Camillo-Forlanini Hospital, 87 Circonvallazione Gianicolense, 00152 Rome, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Lepiane
authors.affiliation: Division of General Surgery and Organ Transplantation, San Camillo-Forlanini Hospital, 87 Circonvallazione Gianicolense, 00152 Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Colasanti
authors.affiliation: Division of General Surgery and Organ Transplantation, San Camillo-Forlanini Hospital, 87 Circonvallazione Gianicolense, 00152 Rome, Italy. gmettorre@scamilloforlanini.rm.it.
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Ettorre
mesh_terms: D064591:Allografts; D016063:Blood Loss, Surgical; D002102:Cadaver; D003080:Cold Temperature; D006801:Humans; D061646:Operative Time; D016577:Pancreaticoduodenectomy / Q000379:methods*; D011183:Postoperative Complications; D014021:Tissue Preservation / Q000379:methods; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014680:Veins / Q000637:transplantation*
keywords: Allograft; Homologous graft; Pancreaticoduodenectomy; Vein resection; Venous reconstruction