title: Study of the radiotherapy sensitizea-tion of retroperitoneal lymph node metastasis in patients by sodium glycididazole.
abstract: To observe the radiotherapy sensitization effect of retroperitoneal lymph node metastasis in patients by sodium glycididazole in recent clinical efficacy and toxicity. A total of 42 patients admitted with metastasis and recurrence of retroperitoneal lymph node from September 2006 to December 2009 were classified with the method of case-control. After three dimensional conformal radiation therapy with or without sodium glycididazole (800 mg/m²) for sensitization, the results of recent clinical efficacy, relief of pain, and Karnofsky score were obtained. Tumor remission rate of patients in sensitization group (with sodium glycididazole) at post-radiotherapy 3 months was significant higher than that in control group (without sodium glycididazole) (52% vs. 24%; P<0.05). Oral dose of morphine daily, and Karnofsky score in anterior-posterior radiotherapy of patients in the sensitization group were significant different with those in the control group (93 ± 12 and 42 ± 6 mg vs. 94 ± 12 and 20 ± 5 mg and (65 ± 4) and (90 ± 9) vs. (64 ± 5) and (80 ± 10), respectively; P<0.01). Sodium glycididazole has positive radiotherapy sensitization to the metastasis or recurrence of retroperitoneal lymph node for digestive tract cancer, which could obviously improve the life quality or release the pain for patients.
authors.affiliation: Radiotherapy department of PLA 404 Hospital, Weihai, Shandong, China.
authors.forename: Gui-Zhi
authors.initials: GZ
authors.lastname: Dong
authors.affiliation: Radiotherapy department of PLA 404 Hospital, Weihai, Shandong, China.
authors.forename: De-Guang
authors.initials: DG
authors.lastname: Wang
authors.affiliation: Radiotherapy department of PLA 404 Hospital, Weihai, Shandong, China.
authors.forename: Hui-Quan
authors.initials: HQ
authors.lastname: Gao
authors.affiliation: Radiotherapy department of PLA 404 Hospital, Weihai, Shandong, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Radiotherapy department of PLA 404 Hospital, Weihai, Shandong, China.
authors.forename: Jing-Jun
authors.initials: JJ
authors.lastname: Liu
authors.affiliation: Radiotherapy department of PLA 404 Hospital, Weihai, Shandong, China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Du
mesh_terms: D016022:Case-Control Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008207:Lymphatic Metastasis / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D010147:Pain Measurement / Q000187:drug effects; D011788:Quality of Life; D011838:Radiation-Sensitizing Agents / Q000009:adverse effects / Q000627:therapeutic use*; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000556:secondary; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D007093:Imidazoles; D011838:Radiation-Sensitizing Agents; C000603632:sodium glycididazole