title: Tribbles in normal and malignant haematopoiesis.
abstract: The tribbles protein family, an evolutionarily conserved group of pseudokinases, have been shown to regulate multiple cellular events including those involved in normal and malignant haematopoiesis. The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ligase-binding domain. In this review, we focus on the role of Trib (mammalian Tribbles homologues) proteins in mammalian haematopoiesis and leukaemia. The Trib proteins show divergent expression in haematopoietic cells, probably indicating cell-specific functions. The roles of the Trib proteins in oncogenesis are also varied and appear to be tissue-specific. Finally, we discuss the potential mechanisms by which the Trib proteins preferentially regulate these processes in multiple cell types.
authors.affiliation: Department of Pathology and Laboratory Medicine, Institute for Immunology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Stein
authors.affiliation: Department of Pathology and Laboratory Medicine, Institute for Immunology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
authors.forename: Ethan A
authors.initials: EA
authors.lastname: Mack
authors.affiliation: Department of Pathology and Laboratory Medicine, Institute for Immunology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
authors.forename: Kelly S
authors.initials: KS
authors.lastname: Rome
authors.affiliation: Department of Pathology and Laboratory Medicine, Institute for Immunology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A. wpear@mail.med.upenn.edu.
authors.forename: Warren S
authors.initials: WS
authors.lastname: Pear
mesh_terms: D000208:Acute Disease; D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics*; D015973:Gene Expression Regulation, Leukemic; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics*; D008957:Models, Genetic; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C493170:TRIB1 protein, human; D017346:Protein Serine-Threonine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C489044:TRIB2 protein, human
keywords: haematopoiesis; leukaemia; tribbles