title: The Circadian Clock in the Regulation of Renal Rhythms.
abstract: Since the kidney is integral to maintenance of fluid and ion homeostasis, and therefore blood pressure regulation, its proper function is paramount. Circadian fluctuations in blood pressure, renal blood flow, glomerular filtration rate, and sodium and water excretion have been documented for decades, if not longer. Recent studies on the role of circadian clock proteins in the regulation of a variety of renal transport genes suggest that the molecular clock in the kidney controls circadian fluctuations in renal function. The circadian clock appears to be a critical regulator of renal function with important implications for the treatment of renal pathologies, which include chronic kidney disease and hypertension. The development, regulation, and mechanism of the kidney clock are reviewed here.
authors.affiliation: Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FloridaDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida.
authors.forename: Kristen
authors.initials: K
authors.lastname: Solocinski
authors.affiliation: Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FloridaDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida Michelle.Gumz@medicine.ufl.edu.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Gumz
mesh_terms: D000818:Animals; D056926:CLOCK Proteins / Q000235:genetics*; D057906:Circadian Clocks / Q000235:genetics* / Q000502:physiology; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D017136:Ion Transport / Q000235:genetics*; D007668:Kidney / Q000166:cytology / Q000502:physiology*
chemical_list: D056926:CLOCK Proteins
keywords: clock; electrolyte; hypertension; ion transport; kidney; potassium; sodium