title: Differential Effect of the Ratio of Right Ventricular Volume to Left Ventricular Volume in Children with Repaired Tetralogy of Fallot.
abstract: We aimed to compare the diagnostic value of indexed right ventricular end-diastolic volume (RVEDVi) and the ratio of right ventricle volume to left ventricle volume (RV/LV ratio) in prediction of the severity of pulmonary regurgitation (PR) expressed as the PR fraction (PRF) after surgery of tetralogy of Fallot (TOF). Forty-one patients with repaired TOF were included in the study. RVEDVi, LVEDVi, RV/LV ratio, PRF and ejection fraction were measured with magnetic resonance imaging. A PRF of more than 20% was considered significant. The predictive capability of two markers (RVEDVi and RV/LV ratio) for significant PR was compared using multivariate linear regression analysis and receiver operating characteristic (ROC) analysis. Both the RV/LV ratio and RVEDVi showed a correlation with PRF (r = 0.526/0.321, p = 0.001/0.041) in the correlation analysis, but in multivariate regression analysis the only independent predictor of PRF was the RV/LV ratio (F = 14.890, p = 0.001). ROC analysis revealed that a better discrimination of significant PR (>20%) from slight types (=20%) PR can be reached with the RV/LV ratio than RVEDVi (AUC = 0.805/0.709, p = 0.01). The RV/LV ratio was better than RVEDVi at differentiating mild from moderate PR (p = 0.006 vs. p = 0.153), and proved superior over RVEDVi in predicting PR based on the PRF criterion.
authors.affiliation: Department of Radiology, Children's Hospital of Fudan University, Shanghai, PR China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yao
authors.forename: Xi-Hong
authors.initials: XH
authors.lastname: Hu
authors.forename: Quan-Li
authors.initials: QL
authors.lastname: Shen
authors.forename: Zhong-Wei
authors.initials: ZW
authors.lastname: Qiao
authors.forename: Mi-Er
authors.initials: ME
authors.lastname: Pa
authors.forename: Bin
authors.initials: B
authors.lastname: Qian
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Yan
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Huang
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006801:Humans; D007223:Infant; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D011665:Pulmonary Valve Insufficiency / Q000503:physiopathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013771:Tetralogy of Fallot / Q000503:physiopathology* / Q000601:surgery; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology*; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right