title: Comparison of subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia.
abstract: OBJECTIVE
  Pregnancy is a known predisposing factor for central serous chorioretinopathy (CSC). Choroidal thickness (CT) increases in patients with CSC. This study was designed to evaluate CT in pregnant women.Patients and methodsThis was a prospective study. Fourteen healthy pregnant women and seven patients with pre-eclampsia were included. Twenty-one normal subjects were also recruited. CT was measured using enhanced-depth imaging optical coherence tomography.
  
  
  RESULTS
  The mean CT of normal subjects, healthy pregnant women and patients with pre-eclampsia were 264.95±21.03, 274.23±29.30 and 389.79±25.13 μm, respectively (normal subjects vs healthy gravidas: P>0.05; normal subjects vs pre-eclampsia: P<0.001; healthy gravidas vs pre-eclampsia: P<0.001). CT decreased from 381.05±22.96 μm to 335.17±9.97 μm 1 week after delivery in patients with pre-eclampsia.
  
  
  CONCLUSIONS
  Pregnancy itself did not increase CT, whereas pre-eclampsia did appear to result in increased CT. This suggests that additional unknown factors induce hyperpermeability in pregnant women.
authors.affiliation: Department of Ophthalmology, Ewha Womans University, School of Medicine, Seoul, South Korea.
authors.forename: J W
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Ewha Womans University, School of Medicine, Seoul, Korea.
authors.forename: M H
authors.initials: MH
authors.lastname: Park
authors.affiliation: Department of Obstetrics and Gynecology, Ewha Womans University, School of Medicine, Seoul, Korea.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Ewha Womans University, School of Medicine, Seoul, South Korea.|Global Top 5 Research Program, Ewha Womans University, School of Medicine, Seoul, Korea.
authors.forename: Y T
authors.initials: YT
authors.lastname: Kim
mesh_terms: D000328:Adult; D002829:Choroid / Q000033:anatomy & histology* / Q000473:pathology*; D005260:Female; D005584:Fovea Centralis; D005865:Gestational Age; D064368:Healthy Volunteers; D006801:Humans; D009929:Organ Size; D011225:Pre-Eclampsia / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D011446:Prospective Studies; D041623:Tomography, Optical Coherence