title: Graphene quantum dots for the inhibition of β amyloid aggregation.
abstract: The aggregation of Aβ peptides is a crucial factor leading to Alzheimer's disease (AD). Inhibiting the Aβ peptide aggregation has become one of the most essential strategies to treat AD. In this work, efficient and low-cytotoxicity inhibitors, graphene quantum dots (GQDs) are reported for their application in inhibiting the aggregation of Aβ peptides. Compared to other carbon materials, the low cytotoxicity and great biocompatibility of GQDs give an advantage to the clinical research for AD. In addition, the GQDs may cross the blood-brain barrier (BBB) because of the small size. It is believed that GQDs may be therapeutic agents against AD. This work provides a novel insight into the development of Alzheimer's drugs.
authors.affiliation: Research Center for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing 100083, P.R. China. xuliping@ustb.edu.cn zhangxueji@ustb.edu.cn.
authors.forename: Yibiao
authors.initials: Y
authors.lastname: Liu
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Xu
authors.forename: Wenhao
authors.initials: W
authors.lastname: Dai
authors.forename: Haifeng
authors.initials: H
authors.lastname: Dong
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Wen
authors.forename: Xueji
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism; D000682:Amyloid / Q000737:chemistry / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D016716:PC12 Cells; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D066263:Protein Aggregation, Pathological / Q000378:metabolism*; D045663:Quantum Dots / Q000737:chemistry*; D051381:Rats
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D006108:Graphite