title: The Colorado Longitudinal Twin Study of Reading Difficulties and ADHD: Etiologies of Comorbidity and Stability.
abstract: Approximately 60% of children with reading difficulties (RD) meet criteria for at least one co-occurring disorder. The most common of these, attention deficit-hyperactivity disorder (ADHD), occurs in 20-40% of individuals with RD. Recent studies have suggested that genetic influences are responsible. To assess the genetic etiologies of RD and the comorbidity of RD and two ADHD symptom dimensions -- inattention (IN) and hyperactivity/impulsivity (H/I) -- we are conducting the first longitudinal twin study of RD and ADHD. Data from twin pairs in which at least one member of the pair met criteria for proband status for RD at initial assessment, and were reassessed 5 years later, were subjected to DeFries-Fulker (DF) analysis. Analyses of reading composite data indicated that over 60% of the proband deficit at initial assessment was due to genetic influences, and that reading deficits at follow-up were due substantially to the same genetic influences. When a bivariate DF model was fitted to reading performance and IN data, genetic influences accounted for 60% of contemporaneous comorbidity and over 60% of the longitudinal relationship. In contrast, analysis of the comorbidity between reading performance and H/I indicated that common genetic influences accounted for only about 20% of the contemporaneous and about 10% of the longitudinal relationships. Results indicate that (1) genetic influences on RD are substantial and highly stable; (2) the comorbidity between RD and IN is due largely to genetic influences, both contemporaneously and longitudinally; and (3) genetic influences contribute significantly less to the comorbidity between RD and H/I.
authors.affiliation: Institute for Behavioral Genetics,University of Colorado,Boulder,CO,USA.
authors.forename: Sally J
authors.initials: SJ
authors.lastname: Wadsworth
authors.affiliation: Institute for Behavioral Genetics,University of Colorado,Boulder,CO,USA.
authors.forename: John C
authors.initials: JC
authors.lastname: DeFries
authors.affiliation: Institute for Behavioral Genetics,University of Colorado,Boulder,CO,USA.
authors.forename: Erik G
authors.initials: EG
authors.lastname: Willcutt
authors.affiliation: Institute for Behavioral Genetics,University of Colorado,Boulder,CO,USA.
authors.forename: Bruce F
authors.initials: BF
authors.lastname: Pennington
authors.affiliation: Institute for Behavioral Genetics,University of Colorado,Boulder,CO,USA.
authors.forename: Richard K
authors.initials: RK
authors.lastname: Olson
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000235:genetics*; D002648:Child; D003120:Colorado; D004200:Diseases in Twins / Q000235:genetics*; D004410:Dyslexia / Q000150:complications / Q000235:genetics*; D042822:Genomic Instability; D006801:Humans; D008137:Longitudinal Studies; D055815:Young Adult
keywords: ADHD; DF analysis; genetic etiology; reading; twin studies