title: Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women.
abstract: A reduction in exercise efficiency with aging limits daily living activities. We examined whether 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) increased exercise efficiency and voluntary achievement of interval walking training (IWT) in older women. Ten women [65 ± 3(SD) yr] who had performed IWT for >12 mo and were currently performing IWT participated in this study. The study was conducted in a placebo-controlled, double-blind crossover design. All subjects underwent two trials for 7 days each in which they performed IWT with ALA+SFC (100 and 115 mg/day, respectively) or placebo supplement intake (CNT), intermittently with a 2-wk washout period. Before and after each trial, subjects underwent a graded cycling test at 27.0 °C atmospheric temperature and 50% relative humidity, and oxygen consumption rate, carbon dioxide production rate, and lactate concentration in plasma were measured. Furthermore, for the first 6 days of each trial, exercise intensity for IWT was measured by accelerometry. We found that, in the ALA+SFC trial, oxygen consumption rate and carbon dioxide production rate during graded cycling decreased by 12% (P < 0.001) and 11% (P = 0.001) at every workload, respectively, accompanied by a 16% reduction in lactate concentration in plasma (P < 0.001), although all remained unchanged in the CNT trial (P > 0.2). All of the reductions were significantly greater in the ALA+SFC than the CNT trial (P < 0.05). Furthermore, the training days, impulse, and time at fast walking were 42% (P = 0.028), 102% (P = 0.027), and 69% (P = 0.039) higher during the ALA+SFC than the CNT intake period, respectively. Thus ALA+SFC supplementation augmented exercise efficiency and thereby improved IWT achievement in older women.
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan; and.
authors.forename: Shizue
authors.initials: S
authors.lastname: Masuki
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan;
authors.forename: Atsumi
authors.initials: A
authors.lastname: Morita
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan; and.
authors.forename: Yoshi-ichiro
authors.initials: Y
authors.lastname: Kamijo
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan;
authors.forename: Shigeki
authors.initials: S
authors.lastname: Ikegawa
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan;
authors.forename: Yufuko
authors.initials: Y
authors.lastname: Kataoka
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan;
authors.forename: Yu
authors.initials: Y
authors.lastname: Ogawa
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan;
authors.forename: Eri
authors.initials: E
authors.lastname: Sumiyoshi
authors.affiliation: Department of R&D, SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of R&D, SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of R&D, SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
authors.forename: Motowo
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan; and nosehir@shinshu-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nose
mesh_terms: D061725:Accelerometry; D000368:Aged; D000622:Aminolevulinic Acid / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D019343:Citric Acid; D018592:Cross-Over Studies; D004032:Diet; D019587:Dietary Supplements; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005260:Female; D005296:Ferrous Compounds / Q000627:therapeutic use*; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D064797:Physical Conditioning, Human / Q000502:physiology*; D016138:Walking / Q000502:physiology*
chemical_list: D005296:Ferrous Compounds; D002245:Carbon Dioxide; D019343:Citric Acid; C016600:ferrous citrate; D019344:Lactic Acid; D000622:Aminolevulinic Acid
keywords: 5-aminolevulinic acid; exercise efficiency; home-based walking training achievement; respiratory response