title: Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells.
abstract: Several mechanisms are associated with brain dysfunction during sepsis; one of the most important are activation of microglia and astrocytes. Activation of glial cells induces changes in permeability of the blood-brain barrier, secretion of inflammatory cytokines, and these alterations could induce neuronal dysfunction. Furthermore, blood-borne leukocytes can also reach the brain and participate in inflammatory response. Mechanisms involved in sepsis-associated brain dysfunction were revised here, focusing in neuroinflammation and involvement of blood-borne leukocytes and glial cells in this process.
authors.affiliation: Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, 88806-000, Brazil. moniquemichels@hotmail.com.
authors.forename: Monique
authors.initials: M
authors.lastname: Michels
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil. amandasteckert@yahoo.com.br.
authors.forename: Amanda V
authors.initials: AV
authors.lastname: Steckert
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil. Joao.L.DeQuevedo@uth.tmc.edu.|Center for Translational Psychiatry, Department of Psychiatry and Behavioral Sciences, Medical School, The University of Texas at Houston, Houston, TX, USA. Joao.L.DeQuevedo@uth.tmc.edu.
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil. Tatiana.Barichello@uth.tmc.edu.|Center for Translational Psychiatry, Department of Psychiatry and Behavioral Sciences, Medical School, The University of Texas at Houston, Houston, TX, USA. Tatiana.Barichello@uth.tmc.edu.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Barichello
authors.affiliation: Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, 88806-000, Brazil. fdpizzol@gmail.com.
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
keywords: Blood-borne leukocytes; Glial cells; Long-term cognitive dysfunction; Neuroinflammation; Sepsis