title: From prospective biobanking to precision medicine: BIO-RAIDs - an EU study protocol in cervical cancer.
abstract: BACKGROUND
  Cervical cancer (CC) is -second to breast cancer- a dominant cause of gynecological cancer-related deaths worldwide. CC tumor biopsies and blood samples are of easy access and vital for the development of future precision medicine strategies.
  
  
  METHODS
  BIO-RAIDs is a prospective multicenter European study, presently recruiting patients in 6 EU countries. Tumor and liquid biopsies from patients with previously non-treated cervical cancer (stages IB2-IV) are collected at defined time points. Patients receive standard primary treatment according to the stage of their disease. 700 patients are planned to be enrolled. The main objectives are the discovery of -dominant molecular alterations, -signalling pathway activation, and -tumor micro-environment patterns that may predict response or resistance to treatment. An exhaustive molecular analysis is performed using 1° Next generation sequencing, 2° Reverse phase protein arrays and 3° Immuno-histochemistry.
  
  
  CONCLUSIONS
  The clinical study BIO-RAIDs is activated in all planned countries, 170 patients have been recruited till now. This study will make an important contribution towards precision medicine treatments in cervical cancer. The results will support the development of clinical practice guidelines for cervical cancer patients to improve their prognosis and their quality of life.
  
  
  BACKGROUND
  Clinicaltrials.gov: NCT02428842 , registered 10 February 2015.
authors.affiliation: Department of Medical Oncology, Institut Curie, 25 Rue d'Ulm, Paris, 75005, France.|Present address: Department of gynecological and breast oncological surgery, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015, Paris, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Ngo
authors.affiliation: Department of Gynecology, Netherlands Cancer Institute - Antoni van Leeuwenhoek (NKI-AVL), P.O. Box 90203, 1006 BE, Amsterdam, The Netherlands.
authors.forename: Sanne
authors.initials: S
authors.lastname: Samuels
authors.affiliation: Department of Medical Oncology, Institut Curie, 25 Rue d'Ulm, Paris, 75005, France.
authors.forename: Ksenia
authors.initials: K
authors.lastname: Bagrintseva
authors.affiliation: Department of Radiation Oncology, Institut Gustave Roussy (IGR), 114 Rue Edouard-Vaillant, 94805, Villejuif Cedex, France.
authors.forename: Andrea
authors.initials: A
authors.lastname: Slocker
authors.affiliation: Department of Medical Oncology, Institut Curie, 25 Rue d'Ulm, Paris, 75005, France.|INSERM U900, Paris, France.|Mines ParisTech, Fontainebleau, France.|CNRS UMR 144, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Hupé
authors.affiliation: Department of Gynecology, Netherlands Cancer Institute - Antoni van Leeuwenhoek (NKI-AVL), P.O. Box 90203, 1006 BE, Amsterdam, The Netherlands.
authors.forename: Gemma
authors.initials: G
authors.lastname: Kenter
authors.affiliation: Department of Gynecology, Institut of Oncology of Vojvodina (IOV), Put Doktora Goldmana 4, 21204, Sremska Kamenica, Serbia.
authors.forename: Marina
authors.initials: M
authors.lastname: Popovic
authors.affiliation: Department of Radiology Gynecology, Institute of Oncology of Republic of Moldova, str. N. Testemiţanu 30, MD-2025, Chişinău, Republica Moldova.
authors.forename: Nina
authors.initials: N
authors.lastname: Samet
authors.affiliation: Department of Medical Oncology, Institut Curie, 25 Rue d'Ulm, Paris, 75005, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Tresca
authors.affiliation: Hannover Clinical Trial Center (HCTC) GmbH, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
authors.forename: Heiko
authors.initials: H
authors.lastname: von der Leyen
authors.affiliation: Department of Radiation Oncology, Institut Gustave Roussy (IGR), 114 Rue Edouard-Vaillant, 94805, Villejuif Cedex, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Deutsch
authors.affiliation: Department of Medical Oncology, Institut Curie, 25 Rue d'Ulm, Paris, 75005, France.
authors.forename: Roman
authors.initials: R
authors.lastname: Rouzier
authors.affiliation: Department of Medical Oncology, Institut Curie, 25 Rue d'Ulm, Paris, 75005, France.
authors.forename: Lisa
authors.initials: L
authors.lastname: Belin
authors.affiliation: Department of Medical Oncology, Institut Curie, 25 Rue d'Ulm, Paris, 75005, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Kamal
authors.affiliation: Department of Medical Oncology, Institut Curie, 25 Rue d'Ulm, Paris, 75005, France. suzy.scholl@curie.fr.|Institut Curie, 26 rue d'Ulm 75248, Paris, Cedex 05, France. suzy.scholl@curie.fr.
authors.forename: Suzy
authors.initials: S
authors.lastname: Scholl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D005260:Female; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D057285:Precision Medicine; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor