title: Gray and White Matter Degenerations in Subjective Memory Impairment: Comparisons with Normal Controls and Mild Cognitive Impairment.
abstract: Subjective memory impairment (SMI) is now increasingly recognized as a risk factor of progression to dementia. This study investigated gray and white matter changes in the brains of SMI patients compared with normal controls and mild cognitive impairment (MCI) patients. We recruited 28 normal controls, 28 subjects with SMI, and 29 patients with MCI aged 60 or older. We analyzed gray and white matter changes using a voxel-based morphometry (VBM), hippocampal volumetry and regions of interest in diffusion tensor imaging (DTI). DTI parameters of corpus callosum and cingulum in SMI showed more white matter changes compared with those in normal controls, they were similar to those in MCI except in the hippocampus, which showed more degenerations in MCI. In VBM, SMI showed atrophy in the frontal, temporal, and parietal lobes compared with normal controls although it was not as extensive as that in MCI. Patients with SMI showed gray and white matter degenerations, the changes were distinct in white matter structures. SMI might be the first presenting symptom within the Alzheimer's disease continuum when combined with additional risk factors and neurodegenerative changes.
authors.affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Yun Jeong
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Department of Neurology, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Bora
authors.initials: B
authors.lastname: Yoon
authors.affiliation: Department of Neurology, Catholic University of Korea, Seoul, Korea.
authors.forename: Yong S
authors.initials: YS
authors.lastname: Shim
authors.affiliation: Department of Radiology, Catholic University of Korea, Seoul, Korea.
authors.forename: Kook Jin
authors.initials: KJ
authors.lastname: Ahn
authors.affiliation: Department of Neurology, Catholic University of Korea, Seoul, Korea.
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Yang
authors.affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology; D019636:Neurodegenerative Diseases / Q000150:complications / Q000473:pathology*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D066127:White Matter / Q000473:pathology*
keywords: Diffusion Tensor Imaging; Mild Cognitive Impairment; Subjective Memory Impairment; Voxel-based Morphometry