title: Clinical parameters predicting development of pulmonary malignancies in patients treated for head and neck squamous cell carcinoma.
abstract: As the locoregional control rates in head and neck squamous cell carcinoma (HNSCC) have increased, these patients may suffer distant metastasis in a higher proportion of cases. Clinicopathological characteristics allowing prediction of high-risk profile would allow adapting posttreatment surveillance to individual risk.
  
  
  
  A retrospective review of all patients with HNSCC treated at the Jewish General Hospital, McGill University, Montreal, Quebec, Canada, between 1999 and 2008 was conducted for this study.
  
  
  
  The study included 428 patients with a mean follow-up of 65 months (±SEM 1.7). Eighty patients (18.6%) developed pulmonary malignancy during follow-up. In multivariate Cox-regression analysis, locoregional failure and current smoking were associated with higher risk of pulmonary malignancy (p < .001 and p = .008, respectively).
  
  
  
  Locoregional failure and smoking persistence are predictors of pulmonary malignancy in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1277-E1280, 2016.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Wayne State University, Detroit, Michigan.
authors.forename: Jeevanandham
authors.initials: J
authors.lastname: Madana
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Grégoire B
authors.initials: GB
authors.lastname: Morand
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Abdulaziz
authors.initials: A
authors.lastname: Alrasheed
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Gabra
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Frédérick
authors.initials: F
authors.lastname: Laliberté
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Wayne State University, Detroit, Michigan.
authors.forename: Luz
authors.initials: L
authors.lastname: Barona-Lleó
authors.affiliation: Department of E.N.T, Darjeeling District Hospital, Darjeeling, India.
authors.forename: Deeke
authors.initials: D
authors.lastname: Yolmo
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Black
authors.affiliation: Department of Radiation Oncology, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Khalil
authors.initials: K
authors.lastname: Sultanem
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Hier
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011792:Quebec; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking
keywords: clinicopathological predictors; distant metastasis; head and neck squamous cell carcinoma; nodal disease