title: Staged laryngeal reconstruction with a prefabricated flap for radiation recurrent glottic carcinoma.
abstract: Although salvage total laryngectomy remains the definitive approach to recurrent/persistent glottic cancer following failed radiation therapy for favorable early-stage disease, it comes at the price of a permanent laryngostome and an impact on quality of life. We describe a three-stage method of laryngeal reconstruction for salvage partial laryngectomy to address the unique challenges of operating on radiation recurrent/persistent cancer.
  
  
  
  This was a single-surgeon retrospective case series of patients who underwent a three-stage laryngeal reconstruction for salvage partial laryngectomy.
  
  
  
  We performed a comprehensive review of the clinical, pathologic, and radiologic files of all patients who underwent a three-stage laryngeal reconstruction for salvage partial laryngectomy.
  
  
  
  Seven male patients underwent a three-stage laryngeal reconstruction following open partial salvage laryngectomy. The average follow-up time since salvage surgery was 55 months. All patients were without evidence of recurrence and demonstrated satisfactory functional outcomes.
  
  
  
  Staged reconstruction provides a more controlled assessment of wound healing and valuable pathologic information regarding the specific disease virulence and adequacy of the margins.
  
  
  
  4. Laryngoscope, 126:1061-1070, 2016.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Beth Israel, New York, New York, U.S.A.
authors.forename: Moustafa W
authors.initials: MW
authors.lastname: Mourad
authors.affiliation: the Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, U.S.A.
authors.forename: Henry K
authors.initials: HK
authors.lastname: Su
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Beth Israel, New York, New York, U.S.A.|the Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, U.S.A.
authors.forename: Jerry R
authors.initials: JR
authors.lastname: Castro
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Beth Israel, New York, New York, U.S.A.|the Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, U.S.A.|Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York, U.S.A.
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Lazarus
authors.affiliation: the Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, U.S.A.
authors.forename: Jason B
authors.initials: JB
authors.lastname: Clain
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Beth Israel, New York, New York, U.S.A.|the Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, U.S.A.
authors.forename: Jacqueline S
authors.initials: JS
authors.lastname: Mojica
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Beth Israel, New York, New York, U.S.A.|the Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, U.S.A.|Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York, U.S.A.
authors.forename: Mark L
authors.initials: ML
authors.lastname: Urken
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000532:radiotherapy / Q000601:surgery*; D005500:Follow-Up Studies; D005931:Glottis / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D058753:Laryngoplasty / Q000379:methods; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000601:surgery*; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D013524:Surgical Flaps; D016896:Treatment Outcome
keywords: Head and neck surgery; laryngeal cancer; reconstruction