title: Diastereoselective Total Synthesis of (-)-Galiellalactone.
abstract: An enantioselective total synthesis of (-)-galiellalactone has been accomplished. The key features of the synthesis involve the highly stereoselective construction of the cis-trisubstituted cyclopentane intermediate by a Pd(0)-catalyzed cyclization, the stereospecific introduction of an angular hydroxyl group by Riley oxidation, and the efficient construction of the tricyclic system of (-)-galiellalactone via a combination of diastereoselective Hosomi-Sakurai crotylation and ring-closing metathesis (RCM).
authors.affiliation: College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
authors.forename: Taewoo
authors.initials: T
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Dankook University , 119 Dandae-ro, Dongnam-gu, Cheonan 330-714, Korea.
authors.forename: Young Taek
authors.initials: YT
authors.lastname: Han
authors.affiliation: College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
authors.forename: Hongchan
authors.initials: H
authors.lastname: An
authors.affiliation: College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
authors.forename: Kyeojin
authors.initials: K
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
authors.forename: Jeeyeon
authors.initials: J
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh