title: Persistent clonal chromosomal abnormalities in a chronic myeloid leukemia patient.
abstract: Clonal cytogenetic abnormalities (CCA) in Philadelphia chromosome (Ph)-negative cells have been reported in a small population of adult chronic myelogenous leukemia (CML) patients during the clinical course, but CCA in pediatric CML patients are rarely reported. We herein report the case of an 8-year-old boy from the onset of CML. Although he had relapse after unrelated bone marrow transplantation when 9 years old, he has since been in complete molecular response on imatinib mesylate treatment. Surprisingly, various CCA have been observed in this patient, including several reciprocal chromosomal translocations in Ph-negative cells for >12 years. Although dysplasia in the bone marrow cells was identified, no overt transformation to myelodysplastic syndrome or acute myeloid leukemia has been observed. The cause of the CCA remains unknown in this patient, and careful observation is required.
authors.affiliation: Department of Pediatrics, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Muraoka
authors.affiliation: Department of Pediatrics, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Washio
authors.affiliation: Department of Pediatrics, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Kanamitu
authors.affiliation: Department of Pediatrics, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Yui
authors.initials: Y
authors.lastname: Kanazawa
authors.affiliation: Department of Hematology/Oncology, Hyogo Children's Hospital, Kobe, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ishida
authors.affiliation: Department of Pediatrics, Osaka University Hospital, Osaka, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Miyamura
authors.affiliation: Department of Pediatrics, Toyonaka Municipal Hospital, Osaka, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Chayama
authors.affiliation: Department of Pediatrics, Kochi Health Sciences Center, Kochi, Japan.
authors.forename: Ritsuo
authors.initials: R
authors.lastname: Nishiuchi
authors.affiliation: Department of Pediatric Hematology and Oncology, Okayama University Hospital, Okayama, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Oda
authors.affiliation: Department of Pediatrics, Okayama University Graduate School of Medicine, Okayama, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
mesh_terms: D002648:Child; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005500:Follow-Up Studies; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics*; D008297:Male
keywords: chromosome instability; chronic myelogenous leukemia; clonal chromosome abnormality; imatinib