title: Renal function assessment in atrial fibrillation: Usefulness of chronic kidney disease epidemiology collaboration vs re-expressed 4 variable modification of diet in renal disease.
abstract: OBJECTIVE
  To compare the performance of the re-expressed Modification of Diet in Renal Disease equation vs the new Chronic Kidney Disease Epidemiology Collaboration equation in patients with non-valvular atrial fibrillation.
  
  
  METHODS
  We studied 911 consecutive patients with non-valvular atrial fibrillation on vitamin-K antagonist. The performance of the re-expressed Modification of Diet in Renal Disease equation vs the new Chronic Kidney Disease Epidemiology Collaboration equation in patients with non-valvular atrial fibrillation with respect to either a composite endpoint of major bleeding, thromboembolic events and all-cause mortality or each individual component of the composite endpoint was assessed using continuous and categorical ≥ 60, 59-30, and < 30 mL/min per 1.73 m(2) estimated glomerular filtration rate.
  
  
  RESULTS
  During 10 ± 3 mo, the composite endpoint occurred in 98 (10.8%) patients: 30 patients developed major bleeding, 18 had thromboembolic events, and 60 died. The new equation provided lower prevalence of renal dysfunction < 60 mL/min per 1.73 m(2) (32.9%), compared with the re-expressed equation (34.1%). Estimated glomerular filtration rate from both equations was independent predictor of composite endpoint (HR = 0.98 and 0.97 for the re-expressed and the new equation, respectively; P < 0.0001) and all-cause mortality (HR = 0.98 for both equations, P < 0.01). Strong association with thromboembolic events was observed only when estimated glomerular filtration rate was < 30 mL/min per 1.73 m(2): HR is 5.1 for the re-expressed equation, and HR = 5.0 for the new equation. No significant association with major bleeding was observed for both equations.
  
  
  CONCLUSIONS
  The new equation reduced the prevalence of renal dysfunction. Both equations performed similarly in predicting major adverse outcomes.
authors.affiliation: Rami Riziq-Yousef Abumuaileq, Emad Abu-Assi, Andrea López-López, Sergio Raposeiras-Roubin, Moisés Rodríguez-Mañero, Luis Martínez-Sande, Francisco Javier García-Seara, Xesus Alberte Fernandez-López, Jose Ramón González-Juanatey, Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Rami Riziq-Yousef
authors.initials: RR
authors.lastname: Abumuaileq
authors.affiliation: Rami Riziq-Yousef Abumuaileq, Emad Abu-Assi, Andrea López-López, Sergio Raposeiras-Roubin, Moisés Rodríguez-Mañero, Luis Martínez-Sande, Francisco Javier García-Seara, Xesus Alberte Fernandez-López, Jose Ramón González-Juanatey, Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Emad
authors.initials: E
authors.lastname: Abu-Assi
authors.affiliation: Rami Riziq-Yousef Abumuaileq, Emad Abu-Assi, Andrea López-López, Sergio Raposeiras-Roubin, Moisés Rodríguez-Mañero, Luis Martínez-Sande, Francisco Javier García-Seara, Xesus Alberte Fernandez-López, Jose Ramón González-Juanatey, Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Andrea
authors.initials: A
authors.lastname: López-López
authors.affiliation: Rami Riziq-Yousef Abumuaileq, Emad Abu-Assi, Andrea López-López, Sergio Raposeiras-Roubin, Moisés Rodríguez-Mañero, Luis Martínez-Sande, Francisco Javier García-Seara, Xesus Alberte Fernandez-López, Jose Ramón González-Juanatey, Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Raposeiras-Roubin
authors.affiliation: Rami Riziq-Yousef Abumuaileq, Emad Abu-Assi, Andrea López-López, Sergio Raposeiras-Roubin, Moisés Rodríguez-Mañero, Luis Martínez-Sande, Francisco Javier García-Seara, Xesus Alberte Fernandez-López, Jose Ramón González-Juanatey, Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Moisés
authors.initials: M
authors.lastname: Rodríguez-Mañero
authors.affiliation: Rami Riziq-Yousef Abumuaileq, Emad Abu-Assi, Andrea López-López, Sergio Raposeiras-Roubin, Moisés Rodríguez-Mañero, Luis Martínez-Sande, Francisco Javier García-Seara, Xesus Alberte Fernandez-López, Jose Ramón González-Juanatey, Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Martínez-Sande
authors.affiliation: Rami Riziq-Yousef Abumuaileq, Emad Abu-Assi, Andrea López-López, Sergio Raposeiras-Roubin, Moisés Rodríguez-Mañero, Luis Martínez-Sande, Francisco Javier García-Seara, Xesus Alberte Fernandez-López, Jose Ramón González-Juanatey, Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: García-Seara
authors.affiliation: Rami Riziq-Yousef Abumuaileq, Emad Abu-Assi, Andrea López-López, Sergio Raposeiras-Roubin, Moisés Rodríguez-Mañero, Luis Martínez-Sande, Francisco Javier García-Seara, Xesus Alberte Fernandez-López, Jose Ramón González-Juanatey, Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Xesus Alberte
authors.initials: XA
authors.lastname: Fernandez-López
authors.affiliation: Rami Riziq-Yousef Abumuaileq, Emad Abu-Assi, Andrea López-López, Sergio Raposeiras-Roubin, Moisés Rodríguez-Mañero, Luis Martínez-Sande, Francisco Javier García-Seara, Xesus Alberte Fernandez-López, Jose Ramón González-Juanatey, Cardiology Department, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
authors.forename: Jose Ramón
authors.initials: JR
authors.lastname: González-Juanatey
keywords: Anticoagulants; Atrial fibrillation; Follow-up studies; Kidney; Prognosis