title: Sunitinib loaded chitosan nanoparticles formulation and its evaluation.
abstract: The nano-polymeric pharmaceutical excipient such as chitosan nanoparticles (CS-NPs) were synthesized for formulating the anticancer drug Sunitinib (STB). The formulation was done through the simple ionic cross linking method. The prepared formulation was characterized by DLS, SEM, FT-IR and XRD. The DLS study reveals that the Sunitinib loaded chitosan nanoparticles (SNB-CS-NPs) were in the size range of < 200 nm. Encapsulation of Sunitinib and validation for the formulation was done using UV spectrophotometry. In vitro drug release and its cytotoxic studies were performed for STB-CS-NPs. This study implies the novel drug delivery system for Sunitinib for the effective sustained delivery.
authors.affiliation: Environmental & Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, Tamil Nadu, India. Electronic address: tgjosephsargunam@gmail.com.
authors.forename: Jayapal John
authors.initials: JJ
authors.lastname: Joseph
authors.affiliation: Environmental & Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, Tamil Nadu, India. Electronic address: dsangeetha@vit.ac.in.
authors.forename: D
authors.initials: D
authors.lastname: Sangeetha
authors.affiliation: Department of Chemistry, D.K.M. College for Women, Vellore 632 001, Tamil Nadu, India. Electronic address: chemist.goms@gmail.com.
authors.forename: Thandapani
authors.initials: T
authors.lastname: Gomathi
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D007211:Indoles / Q000008:administration & dosage* / Q000737:chemistry*; D007700:Kinetics; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011758:Pyrroles / Q000008:administration & dosage* / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D000077210:Sunitinib; D014961:X-Ray Diffraction
chemical_list: D020533:Angiogenesis Inhibitors; D004337:Drug Carriers; D007211:Indoles; D011758:Pyrroles; D048271:Chitosan; D000077210:Sunitinib
keywords: Chitosan nanoparticles; Ionic crosslinking; Sunitinib