title: Nab-paclitaxel in patients with metastatic melanoma.
abstract: Cutaneous melanoma is one of the most aggressive and resistant malignancies in humans. Until recently, progress in the treatment of metastatic melanoma remained dormant for nearly two decades. However, recent advances in immune and targeted therapeutic approaches have led to dramatic and paradigm-shifting advances in the management of metastatic melanoma, that are now leading the way for other malignancies. With the advent of these new therapeutic options, chemotherapy is no longer favored as a first line strategy in metastatic melanoma, but continues to play a role in the salvage treatment of patients that have become refractory to immune-based or targeted therapies. Nab-paclitaxel, a solvent-free alternative to solvent-based paclitaxel, has shown in several trials to be active in metastatic melanoma. Herein, we summarize the role of nab-paclitaxel in the management of patients with advanced melanoma.
authors.affiliation: a Department of Oncology , Mayo Clinic , Rochester , MN , USA.
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Leon-Ferre
authors.affiliation: a Department of Oncology , Mayo Clinic , Rochester , MN , USA.
authors.forename: Svetomir N
authors.initials: SN
authors.lastname: Markovic
mesh_terms: D000418:Albumins / Q000008:administration & dosage* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D009362:Neoplasm Metastasis; D017239:Paclitaxel / Q000008:administration & dosage* / Q000627:therapeutic use; D016879:Salvage Therapy / Q000379:methods; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel
keywords: Melanoma; albumin-bound paclitaxel; cremophore-free paclitaxel; nab-paclitaxel; solvent-free paclitaxel; taxanes