title: Reduction of Total Antioxidant Capacity after Femoral Fracture.
abstract: OBJECTIVE
  The aim of this study was to determine the changes in total antioxidant capacity (TAC) during the fracture healing process.
  
  
  METHODS
  Twenty patients with isolated closed femoral fracture, between the ages 18 and 60 years, were included in the study. The control group was formed with healthy volunteers. Venous blood was drawn from the healthy volunteers once, and from the patients five times during 14 days after fracture. TAC was measured in the sera of these samples.
  
  
  RESULTS
  In the patient group, the serum TAC was the highest in the first 6 hours, whereas there was a decreasing trend on the 3rd, 7th and 14th days, and an increasing trend on the 5th day. The mean serum TAC in all measurements of the patient group were lower than those in the control group.
  
  
  CONCLUSIONS
  The present study suggests that TAC may be decreased in considerable amounts during the first 2 weeks of fracture healing.
authors.affiliation: Department of Orthopaedics and Traumatology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Keskin
authors.forename: A
authors.initials: A
authors.lastname: Kiziltunc
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism* / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D005264:Femoral Fractures / Q000097:blood* / Q000188:drug therapy; D017102:Fracture Healing / Q000502:physiology; D006801:Humans; D007511:Ischemia / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000097:blood
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D008315:Malondialdehyde