title: Genetic polymorphisms in MMP 2, 3, 7, and 9 genes and the susceptibility and clinical outcome of cervical cancer in a Chinese Han population.
abstract: Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of tumor progression, including the invasion and metastasis. However, there are no data about the role of MMP polymorphism in the development of cervical cancer. A hospital-based case-control study was conducted in 230 patients with cervical cancer and 230 healthy controls to investigate the possible association between the MMP2 rs243865, MMP3 rs3025058, MMP7 rs11568818, and MMP9 rs3918242 polymorphisms, respectively, and the risk of cervical cancer. Our results suggested that the MMP2 rs243865-1306 C/T was significantly associated with an increased risk of cervical cancer (CT vs. CC, OR = 1.46; 95 % CI 1.18-3.55; P = 0.032; TT vs. CC, OR = 1.72; 95 % CI 1.28-4.02; P = 0.031; CT + TT vs. CC, OR = 1.43; 95 % CI 1.21-3.44; P = 0.029). Similarly, the MMP7 rs11568818-181A/G genotypes can also elevate the risk of cervical cancer in all genetic models. However, the genotype and allele frequencies of MMP3 rs3025058 and MMP9 rs3918242 polymorphisms in cervical cancer patients were not significantly different from controls. Further analysis showed MMP2 rs243865 and MMP7 rs11568818 genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the MMP2 rs243865 and MMP7 rs11568818 genotype was statistically significantly associated with a poor survival in cervical cancer patients. Our results showed that the MMP2 rs243865 and MMP7 rs11568818 genotypes e were associated with increased susceptibility and development of cervical cancer in Chinese Han population.
authors.affiliation: Department of Gynecology, Qilu Hospital, Shandong University, Jinan, 250021, Shandong, China.|Department of Gynecology, Linyi People's Hospital, 27 Jiefang Road, Linyi, 276003, Shandong, China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Xie
authors.affiliation: Department of Gynecology, Linyi People's Hospital, 27 Jiefang Road, Linyi, 276003, Shandong, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Gynecology, Linyi People's Hospital, 27 Jiefang Road, Linyi, 276003, Shandong, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Gynecology, Linyi People's Hospital, 27 Jiefang Road, Linyi, 276003, Shandong, China.
authors.forename: Zhaojie
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Gynecology, Linyi People's Hospital, 27 Jiefang Road, Linyi, 276003, Shandong, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Neuroscience Research Australia, Sydney, NSW, 2031, Australia.
authors.forename: Huazheng
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Gynecology, Linyi People's Hospital, 27 Jiefang Road, Linyi, 276003, Shandong, China.
authors.forename: Gaoyuan
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Gynecology, Qilu Hospital, Shandong University, Jinan, 250021, Shandong, China.
authors.forename: Xingsheng
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Gynecology, Linyi People's Hospital, 27 Jiefang Road, Linyi, 276003, Shandong, China. haiyanzhang_9999@sina.com.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000368:Aged; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D020783:Matrix Metalloproteinase 7 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
keywords: Cervical cancer; MMPs; Single-nucleotide polymorphism; Susceptibility