title: Hormonal Regulation of Response to Oxidative Stress in Insects-An Update.
abstract: Insects, like other organisms, must deal with a wide variety of potentially challenging environmental factors during the course of their life. An important example of such a challenge is the phenomenon of oxidative stress. This review summarizes the current knowledge on the role of adipokinetic hormones (AKH) as principal stress responsive hormones in insects involved in activation of anti-oxidative stress response pathways. Emphasis is placed on an analysis of oxidative stress experimentally induced by various stressors and monitored by suitable biomarkers, and on detailed characterization of AKH's role in the anti-stress reactions. These reactions are characterized by a significant increase of AKH levels in the insect body, and by effective reversal of the markers-disturbed by the stressors-after co-application of the stressor with AKH. A plausible mechanism of AKH action in the anti-oxidative stress response is discussed as well: this probably involves simultaneous employment of both protein kinase C and cyclic adenosine 3',5'-monophosphate pathways in the presence of extra and intra-cellular Ca(2+) stores, with the possible involvement of the FoxO transcription factors. The role of other insect hormones in the anti-oxidative defense reactions is also discussed.
authors.affiliation: Institute of Entomology, Biology Centre, Academy of Sciences, Branišovská 31, 370 05 České Budějovice, Czech Republic. kodrik@entu.cas.cz.|Faculty of Science, University of South Bohemia, Branišovská 31, 370 05 České Budějovice, Czech Republic. kodrik@entu.cas.cz.
authors.forename: Dalibor
authors.initials: D
authors.lastname: Kodrík
authors.affiliation: Institute of Entomology, Biology Centre, Academy of Sciences, Branišovská 31, 370 05 České Budějovice, Czech Republic. nkrishnan@entomology.msstate.edu.|Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi State, MS 39762, USA. nkrishnan@entomology.msstate.edu.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bednářová
authors.affiliation: Institute of Entomology, Biology Centre, Academy of Sciences, Branišovská 31, 370 05 České Budějovice, Czech Republic. milada.zemanova@prf.jcu.cz.|Faculty of Science, University of South Bohemia, Branišovská 31, 370 05 České Budějovice, Czech Republic. milada.zemanova@prf.jcu.cz.
authors.forename: Milada
authors.initials: M
authors.lastname: Zemanová
authors.affiliation: Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi State, MS 39762, USA. nkrishnan@entomology.msstate.edu.
authors.forename: Natraj
authors.initials: N
authors.lastname: Krishnan
mesh_terms: D000818:Animals; D007301:Insect Hormones / Q000378:metabolism*; D007313:Insecta / Q000378:metabolism*; D009842:Oligopeptides / Q000378:metabolism*; D018384:Oxidative Stress; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D007301:Insect Hormones; D009842:Oligopeptides; C044833:adipokinetic hormone; D011761:Pyrrolidonecarboxylic Acid
keywords: AKH gene; FoxO; adipokinetic hormones (AKH); anti-oxidative mechanisms; free radicals; insect endocrine system; insecticide; oxidative stress; signaling pathway