title: Anxiolytic and Antidepressant Effects of Divaza and Brizantin.
abstract: The anxiolytic and antidepressant activities of complex preparations divaza and brizantin containing antibodies to brain-specific protein S100 were estimated using Vogel conflict test and Nomura forced swimming test. Course treatment (5 days) of brizantin in a dose of 2.5 ml/kg and divaza in a dose of 7.5 ml/kg significantly increased punished drinking in the Vogel conflict test in comparison with the control. Both drugs also improved general emotional behavior during training prior to the test procedure. Brizantin and divaza in a dose of 7.5 ml/kg increased the number of wheel revolutions in the Nomura forced swimming test in comparison with the control; the effect of divaza was more pronounced. High correlation coefficients between the number of wheel revolutions during the first and second 5-min sessions are also indicative of antidepressant action of divaza and brizantin.
authors.affiliation: Materia Medica Holding, Moscow, Russia. guryanovann@materiamedica.ru.
authors.forename: N N
authors.initials: NN
authors.lastname: Yakovleva
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Ertuzun
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: G M
authors.initials: GM
authors.lastname: Molodavkin
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Poseva
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Andreeva
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: Yu L
authors.initials: YL
authors.lastname: Dugina
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Putilovskii
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Epshtein
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000906:Antibodies / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013315:Stress, Psychological / Q000473:pathology; D013550:Swimming / Q000523:psychology
chemical_list: D014151:Anti-Anxiety Agents; D000906:Antibodies; D000928:Antidepressive Agents; C583479:Brizantin; D004338:Drug Combinations; C000610361:divaza; D003975:Diazepam
keywords: S100; antidepressant effect; anxiolytic effect; brizantin; divaza