title: Outcomes of Monoclonal Gammopathy of Undetermined Significance in Patients Who Underwent Kidney Transplantation.
abstract: BACKGROUND
  There are few reports about the clinical course and prognosis of monoclonal gammopathy of undetermined significance (MGUS) in long-term immunosuppressed patients. Our aim was to study the association and evolution of MGUS and renal transplantation.
  
  
  METHODS
  Subjects submitted to renal transplantation between 1996 and 2011 who presented MGUS before or after immunosuppressive treatment was established were selected.
  
  
  RESULTS
  Patients (N = 587) underwent kidney transplantation in our center during the selected period. MGUS was detected in 17 (2.9%) patients (10 men and 7 women with a mean age of 69.9 ± 10.07 years), with a median follow-up of 6 years. All patients had a functioning graft. Nine had MGUS before transplantation. One patient had multiple myeloma, and 8 remained stable. Eight patients had development of MGUS after transplantation. Six patients remained stable, 1 showed no MGUS, and 1 displayed an increased monoclonal component in further controls.
  
  
  CONCLUSIONS
  In our study, renal transplantation is not a risk factor for the development of malignant processes in patients with MGUS before transplantation. There is a group of patients who tend to have MGUS after transplantation; nevertheless, they had a benign evolution during a 6-year follow-up.
authors.affiliation: Department of Nephrology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Bancu
authors.affiliation: Department of Nephrology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; REDinREN 12/0021/0027, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Cañas
authors.affiliation: Department of Nephrology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Juega
authors.affiliation: Department of Nephrology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pérez
authors.affiliation: Department of Biochemistry, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Malumbres
authors.affiliation: Department of Nephrology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; REDinREN 12/0021/0027, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Bonet
authors.affiliation: Department of Nephrology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; REDinREN 12/0021/0027, Spain. Electronic address: rlauzurica.germanstrias@gencat.cat.
authors.forename: R
authors.initials: R
authors.lastname: Lauzurica
mesh_terms: D000368:Aged; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000453:epidemiology*; D009101:Multiple Myeloma / Q000453:epidemiology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D019737:Transplants
chemical_list: D007166:Immunosuppressive Agents