title: Hepatitis C Seroprevalence Among HIV-Infected Childbearing Women in New York State in 2006.
abstract: OBJECTIVE
  To identify factors associated with maternal hepatitis C virus (HCV) seroprevalence and transmission of HCV as identified by qualitative HCV ribonucleic acid (RNA) in the infants of human immunodeficiency virus (HIV) infected women delivering in New York State (NYS) in 2006.
  
  
  METHODS
  In this retrospective cohort study of HIV-exposed infants born in NYS, leftover infant plasma from HIV diagnostic testing was de-identified and tested for HCV. If HCV antibodies were detected, a second specimen collected when the infant was >2 months old was tested for HCV qualitative RNA. Multivariate logistic regression was used to identify factors associated with HCV seropositivity.
  
  
  RESULTS
  In a final sample of 553 live birth events with perinatal HIV exposure, 21 (3.8 %) of tested infant specimens had HCV antibodies indicative of maternal HCV seropositivity. Maternal age at delivery of >35 years, Hispanic ethnicity, white race and injection drug use (IDU) were significantly associated with HCV seropositivity in multivariate analysis. No cases of HCV vertical transmission were identified among HCV exposed infant specimens.
  
  
  CONCLUSIONS
  This statewide population-based study of HIV-infected childbearing women shows HCV seroprevalence of 3.8 %. Maternal age of >35 years and IDU are the strongest predictors of HCV seropositivity. Although no viral transmission was documented, more comprehensive longitudinal testing would be required to conclude that HCV transmission did not occur.
authors.affiliation: Surveillance and Special Projects Unit, Bureau of STD Prevention and Epidemiology, AIDS Institute, New York State Department of Health, ESP, Corning Tower, Albany, NY, 12237, USA. lusine.ghazaryan@health.ny.gov.
authors.forename: L
authors.initials: L
authors.lastname: Ghazaryan
authors.affiliation: Division of Epidemiology, Evaluation and Research, New York State Department of Health, Corning Tower, ESP, Albany, NY, 12237, USA. lou.smith@health.ny.gov.
authors.forename: L
authors.initials: L
authors.lastname: Smith
authors.affiliation: Bloodborne Viruses Laboratory, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY, 12208, USA. monica.parker@health.ny.gov.
authors.forename: M
authors.initials: M
authors.lastname: Parker
authors.affiliation: Viral Hepatitis Section, AIDS Institute, New York State Department of Health, ESP, Corning Tower Room 429, Albany, NY, 12237, USA. colleen.flanigan@health.ny.gov.
authors.forename: C
authors.initials: C
authors.lastname: Flanigan
authors.affiliation: Division of Epidemiology, Evaluation and Research, New York State Department of Health, Corning Tower, ESP, Albany, NY, 12237, USA. wendy.pulver@health.ny.gov.
authors.forename: W
authors.initials: W
authors.lastname: Pulver
authors.affiliation: Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY, 12208, USA. timothy.sullivan@health.ny.gov.
authors.forename: T
authors.initials: T
authors.lastname: Sullivan
authors.affiliation: Cancer Control, American Cancer Society, Eastern Division, One Penny Lane, Latham, NY, 12110, USA. alvaro.carrascal@cancer.org.
authors.forename: A
authors.initials: A
authors.lastname: Carrascal
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000635:transmission / Q000821:virology; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology* / Q000821:virology; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D008423:Maternal Age; D015999:Multivariate Analysis; D009518:New York / Q000453:epidemiology; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000821:virology; D012189:Retrospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000453:epidemiology; D055815:Young Adult
chemical_list: D018937:Hepatitis C Antibodies
keywords: HIV; Hepatitis C; New York State; Pregnant; Seroprevalence