title: The separate and combined effects of monoamine oxidase A inhibition and nicotine on resting state EEG.
abstract: While nicotine is often associated with the neuropsychological effects of tobacco smoke, the robust monoamine oxidase (MAO) inhibition observed in chronic smokers is also likely to play a role. Electroencephalographically-indexed alterations in baseline neural oscillations by nicotine have previously been reported in both smokers and non-smokers, however, little is known about the effects of MAO inhibition in combination with nicotine on resting state EEG. In a sample of 24 healthy non-smoking males, the effects of 6 mg nicotine gum, as well as MAO-A inhibition via 75 mg moclobemide, were investigated in separate and combined conditions over four separate test sessions. Drug effects were observed in the alpha2, beta2, and theta band frequencies. Nicotine increased alpha2 power, and moclobemide decreased beta2 power. Theta power was decreased most robustly by the combination of both drugs. Therefore, this study demonstrated that the nicotinic and MAO inhibiting properties of tobacco may differentially influence fast-wave oscillations (alpha2 and beta2), while acting in synergy to influence theta oscillations.
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada dylan.m.smith@gmail.com.
authors.forename: Dylan M
authors.initials: DM
authors.lastname: Smith
authors.affiliation: Department of Psychology, Mount Saint Vincent University, Halifax, NS, Canada.
authors.forename: Derek
authors.initials: D
authors.lastname: Fisher
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada Royal Ottawa Mental Health Centre, Ottawa, ON, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Blier
authors.affiliation: Royal Ottawa Mental Health Centre, Ottawa, ON, Canada.
authors.forename: Vadim
authors.initials: V
authors.lastname: Ilivitsky
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada Royal Ottawa Mental Health Centre, Ottawa, ON, Canada.
authors.forename: Verner
authors.initials: V
authors.lastname: Knott
mesh_terms: D018592:Cross-Over Studies; D004311:Double-Blind Method; D004347:Drug Interactions; D004357:Drug Synergism; D004569:Electroencephalography; D006801:Humans; D008297:Male; D020912:Moclobemide / Q000008:administration & dosage / Q000494:pharmacology*; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D061485:Tobacco Use Cessation Devices
chemical_list: D008996:Monoamine Oxidase Inhibitors; D018722:Nicotinic Agonists; D009538:Nicotine; D020912:Moclobemide
keywords: EEG; Nicotine; monoamine oxidase inhibition; smoking