title: WEB Treatment of Intracranial Aneurysms: Clinical and Anatomic Results in the French Observatory.
abstract: OBJECTIVE
  Flow disruption with the WEB device is a new technique for the endovascular treatment of wide-neck bifurcation aneurysms. To obtain precise data regarding the safety and efficacy of this treatment with high-quality methodology, the prospective French Observatory study was conducted. Analysis of these data is presented, including 1-year follow-up.
  
  
  METHODS
  Patients with bifurcation aneurysms for which WEB treatment was indicated were included in this prospective, multicenter Good Clinical Practice study. Clinical data, including adverse events and clinical status at 1 month and 1 year, were collected and independently analyzed by a medical monitor. An independent core laboratory evaluated the anatomic results at 1 year following the procedure.
  
  
  RESULTS
  Ten French neurointerventional centers included 62 patients (39 women), 33-74 years of age (mean, 56.6 ± 9.80 years) with 63 aneurysms. Aneurysm locations were the middle cerebral artery in 32 aneurysms (50.8%), anterior communicating artery in 16 (25.4%), basilar artery in 9 (14.3%), and internal carotid artery terminus in 6 (9.5%). Morbidity and mortality at 1 month were, respectively, 3.2% (2/62 patients) and 0.0% (0/62). Morbidity and mortality (unrelated to the treatment) at 1 year were, respectively, 0.0% (0/59) and 3.4% (2/59 patients). At 1 year, complete occlusion was observed in 30/58 aneurysms (51.7%); neck remnant, in 16/58 aneurysms (27.6%); and aneurysm remnant, in 12/58 aneurysms (20.7%).
  
  
  CONCLUSIONS
  This prospective French Observatory study showed very good safety of aneurysm treatment with the WEB, with a high rate of adequate aneurysm occlusion at 1 year (79.3%).
authors.affiliation: From the Department of Neuroradiology (L.P.), Hôpital Maison-Blanche, Université Reims-Champagne-Ardenne, Reims, France lpierot@gmail.com.
authors.forename: L
authors.identifier: http://orcid.org/0000-0002-2523-4909
authors.initials: L
authors.lastname: Pierot
authors.affiliation: Hôpital Beaujon, (J.M., L.S.), Assistance Publique-Hôpitaux de Paris, Clichy, France.
authors.forename: J
authors.identifier: http://orcid.org/0000-0002-2086-2973
authors.initials: J
authors.lastname: Moret
authors.affiliation: Centre Hospitalier Universitaire de Lyon (F.T.), Lyon, France.
authors.forename: F
authors.identifier: http://orcid.org/0000-0001-5006-2320
authors.initials: F
authors.lastname: Turjman
authors.affiliation: Centre Hospitalier Universitaire de Tours (D.H.), Tours, France.
authors.forename: D
authors.identifier: http://orcid.org/0000-0002-4533-4296
authors.initials: D
authors.lastname: Herbreteau
authors.affiliation: Centre Hospitalier Universitaire de Rennes (H.R., J.-Y.G.), Rennes, France.
authors.forename: H
authors.identifier: http://orcid.org/0000-0002-0458-3309
authors.initials: H
authors.lastname: Raoult
authors.affiliation: Centre Hospitalier Universitaire de Bordeaux (X.B.), Bordeaux, France.
authors.forename: X
authors.identifier: http://orcid.org/0000-0002-4932-1484
authors.initials: X
authors.lastname: Barreau
authors.affiliation: Centre Hospitalier Universitaire de Poitiers (S.V.), Poitiers, France.
authors.forename: S
authors.identifier: http://orcid.org/0000-0002-3120-487X
authors.initials: S
authors.lastname: Velasco
authors.affiliation: Centre Hospitalier Universitaire de Nantes (H.D.), Nantes, France.
authors.forename: H
authors.identifier: http://orcid.org/0000-0002-4665-1461
authors.initials: H
authors.lastname: Desal
authors.affiliation: Centre Hospitalier Universitaire de Toulouse (A.-C.J., C.C.), Toulouse, France.
authors.forename: A-C
authors.identifier: http://orcid.org/0000-0003-4910-6386
authors.initials: AC
authors.lastname: Januel
authors.affiliation: Centre Hospitalier Universitaire de Caen (P.C.), Caen, France.
authors.forename: P
authors.identifier: http://orcid.org/0000-0002-6337-4208
authors.initials: P
authors.lastname: Courtheoux
authors.affiliation: Centre Hospitalier Universitaire de Rennes (H.R., J.-Y.G.), Rennes, France.
authors.forename: J-Y
authors.identifier: http://orcid.org/0000-0002-8057-6004
authors.initials: JY
authors.lastname: Gauvrit
authors.affiliation: Centre Hospitalier Universitaire de Toulouse (A.-C.J., C.C.), Toulouse, France.
authors.forename: C
authors.identifier: http://orcid.org/0000-0003-4287-2627
authors.initials: C
authors.lastname: Cognard
authors.affiliation: Oxford Neurovascular and Neuroradiology Research Unit (A.M., J.B.), Oxford Radcliffe Hospital, Oxford, UK.
authors.forename: A
authors.identifier: http://orcid.org/0000-0002-8757-9021
authors.initials: A
authors.lastname: Molyneux
authors.affiliation: From the Department of Neuroradiology (L.P.), Hôpital Maison-Blanche, Université Reims-Champagne-Ardenne, Reims, France.
authors.forename: J
authors.identifier: http://orcid.org/0000-0002-1268-3000
authors.initials: J
authors.lastname: Byrne
authors.affiliation: Hôpital Beaujon, (J.M., L.S.), Assistance Publique-Hôpitaux de Paris, Clichy, France.
authors.forename: L
authors.identifier: http://orcid.org/0000-0002-6748-8528
authors.initials: L
authors.lastname: Spelle
mesh_terms: D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000628:therapy; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D012008:Recurrence; D015607:Stents / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors