title: Oncogenic PI3Kα promotes multipotency in breast epithelial cells.
abstract: The phosphoinositide 3-kinase (PI3K) signaling pathway is among the most frequently altered in cancer. Now, two studies show that a mutated oncogenic PI3Kα, commonly found in breast cancer, leads to dedifferentiation or destabilization of luminal and basal epithelial lineages, which in turn leads to increased cancer cell heterogeneity.
authors.affiliation: Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK. klaus.okkenhaug@babraham.ac.uk rahul.roychoudhuri@babraham.ac.uk.
authors.forename: Klaus
authors.initials: K
authors.lastname: Okkenhaug
authors.affiliation: Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK. klaus.okkenhaug@babraham.ac.uk rahul.roychoudhuri@babraham.ac.uk.
authors.forename: Rahul
authors.initials: R
authors.lastname: Roychoudhuri
mesh_terms: D001940:Breast / Q000201:enzymology* / Q000473:pathology; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics; D004847:Epithelial Cells / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D039902:Multipotent Stem Cells / Q000201:enzymology* / Q000473:pathology; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000201:enzymology / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; D019869:Phosphatidylinositol 3-Kinases