title: Functional neural correlates of social approval in schizophrenia.
abstract: Social approval is a reward that uses abstract social reinforcers to guide interpersonal interactions. Few studies have specifically explored social reward processing and its related neural substrates in schizophrenia. Fifteen patients with schizophrenia and fifteen healthy controls participated in a two-part study to explore the functional neural correlates of social approval. In the first session, participants were led to believe their personality would be assessed based on their results from various questionnaires and an interview. Participants were then presented with the results of their supposed evaluation in the scanner, while engaging in a relevant fMRI social approval task. Subjects provided subjective reports of pleasure associated with receiving self-directed positive or negative feedback. Higher activation of the right parietal lobe was found in controls compared with individuals with schizophrenia. Both groups rated traits from the high social reward condition as more pleasurable than the low social reward condition, while intergroup differences emerged in the low social reward condition. Positive correlations were found in patients only between subjective ratings of positive feedback and right insula activation, and a relevant behavioural measure. Evidence suggests potential neural substrates underlying the cognitive representation of social reputation in schizophrenia.
authors.affiliation: Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada H3A 0G4 Douglas Mental Health University Institute, Montréal, QC, Canada H4H 1R3 philippe-olivier.harvey@douglas.mcgill.ca.
authors.forename: Carolina S
authors.initials: CS
authors.lastname: Makowski
authors.affiliation: Douglas Mental Health University Institute, Montréal, QC, Canada H4H 1R3 Department of Psychiatry, McGill University, Montreal, QC, Canada H3A 0G4.
authors.forename: Martin
authors.initials: M
authors.lastname: Lepage
authors.affiliation: Douglas Mental Health University Institute, Montréal, QC, Canada H4H 1R3 philippe-olivier.harvey@douglas.mcgill.ca.
authors.forename: Philippe-Olivier
authors.initials: PO
authors.lastname: Harvey
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003071:Cognition; D030141:Feedback, Psychological; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000503:physiopathology; D010551:Personality; D012201:Reward; D012559:Schizophrenia / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012919:Social Behavior; D055815:Young Adult
keywords: fMRI; schizophrenia; self-processing; social cognition; social reward