title: Survival advantage associated with multimodal therapy in women with node-positive (stage-IIIC) uterine papillary serous carcinoma: a National Cancer Database study.
abstract: OBJECTIVE
  Uterine papillary serous carcinoma (UPSC) is an aggressive subtype of endometrial cancer. Adjuvant chemotherapy (CT) has become standard care in treatment of women with advanced-stage UPSC, but the role of consolidative radiotherapy (RT) is unclear. This study aims to evaluate survival outcomes of multimodal therapy.
  
  
  METHODS
  Retrospective cohort study using a National Cancer Database (NCDB).
  
  
  METHODS
  United States of America.
  
  
  METHODS
  A total of 1816 women diagnosed with UPSC.
  
  
  METHODS
  All women diagnosed with surgically staged FIGO (International Federation of Gynecology and Obstetrics) stage-IIIC UPSC were identified in the NCDB from January 1998 to December 2010. Overall survival (OS) was estimated using the Kaplan-Meier method. Univariate and multivariable analyses were performed to identify and control for prognostic factors.
  
  
  METHODS
  Overall survival.
  
  
  RESULTS
  A total of 398 057 cases of uterine cancer were identified, 22 106 of which were UPSC. Of these women, 14 093 underwent lymph-node examination, 2902 (20.6%) were found to have stage-IIIC disease, and 1816 received chemotherapy. Younger age and higher number of total lymph nodes examined were independently predictive of receiving multimodality (CT + RT) therapy, compared with CT only. Median OS was 33.6 and 42.6 months, for the CT and CT + RT groups, respectively (P < 0.0005). Exploratory univariate analyses found age, comorbidity index, tumour size, and number of dissected and positive lymph nodes to be also associated with survival. Multivariable analysis controlling for the above found the use of consolidative radiotherapy to be independently predictive of improved OS, with a hazard ratio of 0.69 (95% confidence interval, 95% CI 0.56-0.84).
  
  
  CONCLUSIONS
  Patients with stage-IIIC UPSC may benefit from multimodal treatment that includes adjuvant radiotherapy in addition to chemotherapy.
  
  
  CONCLUSIONS
  In this study of 1816 women with uterine papillary serous cancer, adjuvant radiotherapy increased survival.
authors.affiliation: Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Lin
authors.affiliation: Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA.
authors.forename: K
authors.initials: K
authors.lastname: Muñiz
authors.affiliation: Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA.
authors.forename: P
authors.initials: P
authors.lastname: Sukumvanich
authors.affiliation: University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: P
authors.initials: P
authors.lastname: Gehrig
authors.affiliation: Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Beriwal
authors.affiliation: Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Kelley
authors.affiliation: Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Edwards
authors.affiliation: Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA. olawaiyea@mail.magee.edu.
authors.forename: A B
authors.initials: AB
authors.lastname: Olawaiye
mesh_terms: D000368:Aged; D002291:Carcinoma, Papillary / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant / Q000379:methods / Q000401:mortality*; D003131:Combined Modality Therapy; D016208:Databases, Factual; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant / Q000379:methods / Q000401:mortality*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014481:United States; D014594:Uterine Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy
keywords: Chemotherapy; UPSC; radiotherapy