title: Verrucous Oesophageal Carcinoma: Single Case Report and Case Series Including 15 Patients - Issues for Consideration of Therapeutic Strategies.
abstract: BACKGROUND
  Verrucous carcinomas (VC) of the oesophagus are a rarity. Due to their histological resemblance to squamous cell carcinoma, the diagnostic and treatment standards applicable to the latter have so far also been applied to VC as a disease entity. Quite limited data are available including two case series of 5 or 11 patients. The present study reports on a single case treated by local endoscopic therapy and a series of 15 patients, 9 of whom received local endoscopic therapy.
  
  
  METHODS
  The data for patients diagnosed with VC of the oesophagus who had been treated from January 1999 to May 2011 were analysed retrospectively.
  
  
  RESULTS
  15 patients with the diagnosis of oesophageal VC were included. The male-female ratio was 3:1. 9 of 11 pT1-VC patients presented with the cardinal symptom dysphagia or odynophagia. For the majority of the patients, the growth pattern is one of extensive superficial expansion showing a median length of 9 cm (range: 2-22 cm). Surprisingly, none of the VC patients showed lymph node or distant metastasis. 9 of 15 VC patients received local endoscopic therapy; 4 were treated with curative intent and 5 were treated palliatively. 3 patients underwent oesophageal resection, and definitive chemoradiotherapy was administered in a further 3 patients. One severe complication, consisting of a postoperative anastomotic insufficiency with a fatal outcome, occurred in this group of patients.
  
  
  CONCLUSIONS
  This is the largest published study describing patients diagnosed with VC of the oesophagus so far. The option of local endoscopic therapy and its results in 9 patients are reported for the first time. The superficial growth pattern of the tumour and the frequent absence of lymph node or distant metastasis suggest that endoscopic resection can be carried out as a diagnostic and/or therapeutic approach. Due to the rarity of this entity, the case numbers are unfortunately so limited that evidence-based recommendations are unlikely to become available even in the future.
authors.affiliation: Internal Medicine, Vivantes Klinikum im Friedrichshain, University Teaching Hospital of the Humboldt University Berlin (Charité), Berlin, Germany.
authors.forename: Angelika
authors.initials: A
authors.lastname: Behrens
authors.affiliation: Institute of Pathology, Kulmbach Hospital, Kulmbach, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Stolte
authors.affiliation: Internal Medicine, St. John of God Hospital, Regensburg, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Pech
authors.affiliation: Internal Medicine II, Sana Klinikum Offenbach, Offenbach, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: May
authors.affiliation: Internal Medicine II, Sana Klinikum Offenbach, Offenbach, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Ell
keywords: Case series; Endoscopic therapy; Therapeutic strategy; Verrucous oesophageal carcinoma