title: Surface Modification of Polydivinylbenzene Microspheres with a Fluorinated Glycopolymer Using Thiol-Halogen Click Chemistry.
abstract: Distillation-precipitation polymerization of divinylbenzene was applied to obtain uniform-sized polymeric microspheres. The microspheres were then modified with polypentafluorostyrene chains utilizing surface-initiated atom transfer radical polymerization techniques. The hydrophobic fluoropolymer-coated microsphere was then converted to a hydrophilic biopolymer by performing thiol-halogen click chemistry between polypentafluorostyrene and 1-thio-β-D-glucose sodium salt. The semi-fluorinated glycopolymer showed good binding ability with Concanavalin A as determined by confocal microscopy and turbidity experiments.
authors.affiliation: Centre for Advanced Macromolecular Design, School of Chemical Engineering, The University of New South Wales, Sydney, NSW, Australia, 2052.
authors.forename: Wentao
authors.initials: W
authors.lastname: Song
authors.affiliation: Centre for Advanced Macromolecular Design, School of Chemical Engineering, The University of New South Wales, Sydney, NSW, Australia, 2052. a.granville@unsw.edu.au.
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Granville
mesh_terms: D057930:Click Chemistry; D003208:Concanavalin A / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry; D005947:Glucose / Q000031:analogs & derivatives* / Q000737:chemistry; D006001:Glycoconjugates / Q000138:chemical synthesis*; D008863:Microspheres; D011108:Polymers / Q000138:chemical synthesis*; D011137:Polystyrenes / Q000737:chemistry; D013343:Styrenes / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D006001:Glycoconjugates; D011108:Polymers; D011137:Polystyrenes; D013343:Styrenes; D003208:Concanavalin A; D005461:Fluorine; C018399:1-thioglucose; C056745:poly(divinylbenzene); D005947:Glucose
keywords: Atom transfer radical polymerization; Glycopolymers; Polymeric microspheres; Protein binding; Surface modification