title: [Oncological principles for local control of primary tumor].
abstract: OBJECTIVE
  Review of the databases of carcinogenesis and the principles of local control of the primary tumor in order to decrease the risk of tumor progression and predict metastatic behavior.
  
  
  METHODS
  Review of the literature using Medline databases based on scientific relevance. Research was centered on the characteristics of solid tumor development, the basics of local control of the primary tumor, latest advance in genomics and the oncological principles applied on prostate cancer surgery.
  
  
  RESULTS
  The cornerstone in order to cure a local or locally advanced cancer is to eradicate the primary tumor. This should be done using effective methods that can assure local control, decrease the risk of progression and metastasis. The oncological surgery is the most important step in order to have this tumor control, beside radiotherapy and systemic therapy associated. In localized prostate cancer, surgery remains the gold standard between the multiple therapeutic modalities proposed.
  
  
  CONCLUSIONS
  The local control of solid malignant tumor is primordial in order to change the natural history of the disease and decrease its risk of progression. This is the goal of oncological surgery, and starting from these principles radical prostatectomy was favored.
authors.affiliation: Département d'urologie-andrologie-transplantation rénale, CHU Rangueil, 1, avenue Jean-Poulhès, 31059 Toulouse cedex 9, France. Electronic address: soulie.m@chu-toulouse.fr.
authors.forename: M
authors.initials: M
authors.lastname: Soulié
authors.affiliation: Service de chirurgie digestive, CHU Purpan, place Baylac, 31059 Toulouse cedex 9, France.
authors.forename: G
authors.initials: G
authors.lastname: Portier
authors.affiliation: Service d'urologie et de transplantation rénale et pancréatique, CHU Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Salomon
mesh_terms: D018450:Disease Progression; D006801:Humans; D008495:Medical Oncology; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*
keywords: Cancer; Cancer de la prostate; Cancer du rectum; Cancer du rein; Chirurgie oncologique; Contrôle local; Genomic; Génomique; Local control; Local recurrence; Metastasis; Métastases; Oncologic surgery; Prostate cancer; Rectal cancer; Renal cell carcinoma; Récidive locale