title: The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers.
abstract: A normal evolution of the cell-cycle phases consists of multiple consecutive events, which makes it a highly complex process. Its preservation is regulated by Cyclin-Cdks (cyclin-dependent kinases) interactions and protein degradation, which is often controlled by the ubiquitin-mediated proteolysis. The goal of this review is to emphasize the most important features of the regulation of the cell-cycle involved in cancerogenesis, by presenting the involvement of E3 ubiquitin ligases SCF (Skp1-Cul1-F-box protein) and APC/C (Anaphase-promoting complex/cyclosome) in human malignancies. Also, we discuss the importance of the ubiquitin proteasome pathway blockade in cancer treatment. We know that a better understanding of the regulatory biology of the cell cycle can lead to the development of new target therapies for cancer.
authors.affiliation: Department of Medical Oncology, "Prof. Dr. Ion Chiricuta" Institute of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Ovidiu Vasile
authors.initials: OV
authors.lastname: Bochis
authors.affiliation: Department of Pathology, "Prof. Dr. Ion Chiricuta" Institute of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Fetica
authors.affiliation: Department of Surgery, "Prof. Dr. Ion Chiricuta" Institute of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Catalin
authors.initials: C
authors.lastname: Vlad
authors.affiliation: Department of Surgery, "Prof. Dr. Ion Chiricuta" Institute of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Patriciu
authors.initials: P
authors.lastname: Achimas-Cadariu
authors.affiliation: Department of Surgery, "Prof. Dr. Ion Chiricuta" Institute of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Irimie
keywords: SCF; cancer; cell cycle; ubiquitin