title: Hypercapnia-Induced Changes in Cerebral Blood Flow Against the Background of Experimental Cerebral Circulatory Failure.
abstract: The peculiarities of hypercapnia-induced blood circulatory changes in the local cortical and subcortical regions of the brain and the character of disturbances of the adequate (vasodilator) responses to CO2 were examined on rabbits with experimental chronic cerebral circulatory failure. The study revealed moderation of local vasodilator effect of CO2 and reversal of the circulatory reactions to CO2 manifested in a decrease of local blood fl ow instead of its elevation. The data argue for individual use of carbogen therapy in relation to initial state of the functional organism systems.
authors.affiliation: Department of Development and Translation of Novel Non-Pharmacological Therapies, I. M. Sechenov First Moscow State Medical University, Moskva, Russia. lum8@yandex.ru.
authors.forename: L M
authors.initials: LM
authors.lastname: Kudaeva
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D002545:Brain Ischemia / Q000097:blood / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood / Q000494:pharmacology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D006935:Hypercapnia / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D011817:Rabbits; D014665:Vasodilator Agents / Q000097:blood / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D002245:Carbon Dioxide
keywords: carbogen therapy; cerebral circulation; cerebral circulatory failure; hypercapnia