title: A comprehensive study of interactions between lectins and glycoproteins for the development of effective theranostic nanoagents.
abstract: A comprehensive study of the interactions between lectins and glycoproteins possessing different glycosylation profiles in the composition of nanoparticles was carried out in order to find specifically interacting protein pairs for the creation of novel classes of multifunctional nanoagets that based on protein-assisted selfassembly. We obtained information about specific interactions of certain lectins with selected glycoproteins as well as about the ability of certain monosaccharides to competitively inhibit binding of glycoproteins with lectins. These protein-mediated interactions may be involved in the formulation of self-assembled nanoparticles for therapy and diagnostics of various diseases.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia. viktoriya.shipunova@phystech.edu.|Nizhny Novgorod State University, pr. Gagarina 23, Nizhny Novgorod, 603600, Russia. viktoriya.shipunova@phystech.edu.
authors.forename: V O
authors.initials: VO
authors.lastname: Shipunova
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.|Moscow Institute of Physics and Technology (State University), Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700, Russia.|Prokhorov Institute of General Physics, Russian Academy of Sciences, ul. Vavilova 38, Moscow, 119991, Russia.
authors.forename: M P
authors.initials: MP
authors.lastname: Nikitin
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.|Moscow Institute of Physics and Technology (State University), Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Zelepukin
authors.affiliation: Prokhorov Institute of General Physics, Russian Academy of Sciences, ul. Vavilova 38, Moscow, 119991, Russia.|National Research Nuclear University "Moscow Engineering Physics Institute,", Moscow, Russia.
authors.forename: P I
authors.initials: PI
authors.lastname: Nikitin
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.|Nizhny Novgorod State University, pr. Gagarina 23, Nizhny Novgorod, 603600, Russia.
authors.forename: S M
authors.initials: SM
authors.lastname: Deyev
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
authors.forename: R V
authors.initials: RV
authors.lastname: Petrov
mesh_terms: D000818:Animals; D032449:Canavalia; D002417:Cattle; D002645:Chickens; D002846:Chromatography, Affinity; D006023:Glycoproteins / Q000378:metabolism*; D006046:Gold; D006801:Humans; D027806:Lens Plant; D058185:Magnetite Nanoparticles; D053768:Metal Nanoparticles; D037121:Plant Lectins / Q000378:metabolism*; D013025:Glycine max; D013552:Swine; D000068936:Theranostic Nanomedicine / Q000379:methods; D014908:Triticum
chemical_list: D006023:Glycoproteins; D058185:Magnetite Nanoparticles; D037121:Plant Lectins; D006046:Gold