title: Human papillomavirus infection among Uyghur women with cervical intraepithelial neoplasia in Xinjiang area.
abstract: OBJECTIVE
  To obtain the baseline data of Uyghur women for human papillomavirus (HPV) vaccination in Xinjiang.
  
  
  METHODS
  The authors analyzed the infection and distribution characteristics of HPV genotypes in genital tracts among Uyghur women with cervical intraepithelial neoplasia (CIN) in Urumqi of Xinjiang. A total of 1,431 eligible cases involved in this trial. All cervical samples from these patients were detected for HPV genotype.
  
  
  RESULTS
  High-risk HPV was identified in 24.7% of 979 histologically confirmed normal samples and 89.2% of 452 samples with CIN (p < 0.05). The prevalence of one single high-risk type, low-risk type, and multiple HPV types were 74.6%, 10.4%, and 4.2%, respectively. A single high risk HPV infection progressively increased with the severity of cervical lesions significantly (chi2 = 31.53, p < 0.01). While interestingly multiple infection and single low risk HPV infection were decreased with the severity of cervical lesions, and there was significant difference chi2 = 6.44, p <0.05; chi2 = 4.85, p < 0.05). The major prevalent high-risk HPV genotypes in 346 samples of CIN II-III were HPV-16, -58, -31, -33, -68,-18,-45, and -39. The comparison of HPV genotype distributions between normal cytology and CIN II-III was analyzed. The estimated risks for progression from viral infection to CIN II-III was highest in HPV-33 (prevalence ratio (PR), 2.62), followed by HPV-31 (2.27), HPV-16 (1.92), HPV-58 (1.62), HPV-18 (1.51), HPV-68 (1.05), and HPV-39 (1.05), suggesting that the six genotypes of HPV-31, -16, -58, -18, -68, and -39 (PR > 1) are higher-risk HPV types in Uyghur women with CIN in Urumqi of Xinjiang. There was no association between multiple infection and cervical lesion progression (0.31, PR < 1).
  
  
  CONCLUSIONS
  Except for the common HPV-16, -58, -31, -33, -18 in Xinjiang, HPV-68 and HPV-39 may be the oncogenic subtypes to Uyghur female with CIN in Xinjiang. Distinguishing these HPV subtypes may have implications for future cervical screening strategies and vaccine implementation. Multiple infections were not association with an increased risk of high-grade cervical neoplasia.
authors.forename: R
authors.initials: R
authors.lastname: Du
authors.forename: Z F
authors.initials: ZF
authors.lastname: Chen
authors.forename: X H
authors.initials: XH
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics; D030361:Papillomavirus Infections / Q000453:epidemiology*; D002578:Uterine Cervical Dysplasia / Q000209:etiology / Q000473:pathology / Q000821:virology*