title: Multifunctional MRI/PET Nanobeacons Derived from the in Situ Self-Assembly of Translational Polymers and Clinical Cargo through Coalescent Intermolecular Forces.
abstract: Novel multifunctional platforms are needed for oncology in order to assist physicians during surgery and chemotherapy. In the present study, we show that polymeric nanobeacons, consisting of the glucose-based polymer dextran, can be used to guide surgery and improve drug delivery. For imaging, the nanobeacons stably retained the positron emitter 89-zirconium and the MRI contrast agent gadolinium, without the need of a chelator. In addition to using them for PET imaging, the (89)Zr-nanobeacons guided the surgical resection of sentinel lymph nodes, utilizing their inherent Cerenkov luminescence. Through weak electrostatic interactions, the nanoparticles carried combinations of chemotherapeutics for the simultaneous inhibition of oncogenic pathways, resulting in enhanced tumor regression. The nanobeacons also allowed monitoring of drug release via MRI, through the quenching of the gadolinium signal by the coloaded drug, making them a new multifunctional theranostic nanotechnology platform for the clinic.
authors.affiliation: Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital , 55 Fruit Street, Boston, Massachusetts 02114, United States.
authors.forename: Charalambos
authors.initials: C
authors.lastname: Kaittanis
authors.affiliation: Department of Chemistry, Hunter College and Graduate Center of the City University of New York , New York, New York 10065, United States.
authors.forename: Travis M
authors.initials: TM
authors.lastname: Shaffer
authors.forename: Alexander
authors.initials: A
authors.lastname: Bolaender
authors.forename: Zachary
authors.initials: Z
authors.lastname: Appelbaum
authors.forename: Jeremy
authors.initials: J
authors.lastname: Appelbaum
authors.forename: Gabriela
authors.initials: G
authors.lastname: Chiosis
authors.forename: Jan
authors.initials: J
authors.lastname: Grimm
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008819:Mice, Nude; D036103:Nanotechnology; D011108:Polymers / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D011108:Polymers
keywords: Cerenkov-guided surgery; Lymph node resection; combination therapy