title: Association of EBV and HPV co-infection with the development of cervical cancer in ethnic Uyghur women.
abstract: OBJECTIVE
  Study on the role of Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in the development of cervical cancer.
  
  
  METHODS
  We collected 178 cases of cervical tissue specimens of Uyghur women with cervicitis, cervical intraepithelial neoplasia (CIN I, CIN II-III), and cervical squamous cell carcinoma (CSCC). EBV- and HPV-DNA were detected by PCR of tissue DNA. EBV protein expression was checked by immunohistochemistry.
  
  
  RESULTS
  HPV-DNA was detectable in 2.5, 12.5, 68.0, and 96.4% of cases of cervicitis, CIN I, CIN II-III, and cervical cancer, respectively. For EBV-DNA, these numbers were 0, 3.1, 28.0, and 69.6%. There was a significant difference between the groups of cervicitis, CIN II-III, and cancer with respect to both HPV and EBV positivity rates (p < 0.05). Further analysis indicated that cervical lesion pathogenesis was not only accompanied by a gradually increasing rate of HPV or EBV-DNA alone, but also by an increasing rate of HPV-EBV dual infection (r = 0.46; p < 0.0 1). EBV protein expression was positive in 89.7% of EBV-DNA positive cases (34/39) and 6% of EBV-DNA negative cases (1/17).
  
  
  CONCLUSIONS
  Cervical cancer development and progression may be closely associated with the dual-infection by HPV and EBV.
authors.forename: A
authors.initials: A
authors.lastname: Abudoukadeer
authors.forename: M
authors.initials: M
authors.lastname: Niyazi
authors.forename: A
authors.initials: A
authors.lastname: Aikula
authors.forename: M
authors.initials: M
authors.lastname: Kamilijian
authors.forename: X
authors.initials: X
authors.lastname: Sulaiman
authors.forename: A
authors.initials: A
authors.lastname: Mutailipu
authors.forename: A
authors.initials: A
authors.lastname: Abudula
mesh_terms: D000328:Adult; D002681:China / Q000208:ethnology; D060085:Coinfection / Q000150:complications*; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications*; D002583:Uterine Cervical Neoplasms / Q000209:etiology*
chemical_list: D004279:DNA, Viral