title: Quantitative Analysis of Enlarged Cervical Lymph Nodes with Ultrasound Elastography.
abstract: PURPSOE: To investigate the diagnostic value of quantitative analysis of a tissue diffusion and virtual touch tissue imaging quantification (VTIQ) technique with acoustic radiation force impulse (ARFI) elastography for assessing enlarged cervical lymph nodes.
  
  
  METHODS
  Fifty-six enlarged cervical lymph nodes confirmed by pathologic diagnoses were covered in the study. According to the results of pathologic diagnosis, patients were classified into benign and malignant groups. All the patients were examined by both conventional ultrasonography and elastography. AREA% and shear wave velocity (SWV) in ROI of different groups were calculated and compared using ROC curves. Cut-off points of AREA% and SWV were determined with receiver operating characteristic curves.
  
  
  RESULTS
  Final histopathological results revealed 21 cases of benign and 35 cases of malignant lymph nodes. The mean values of AREA% and SWV in benign and malignant groups were 45.0 ± 17.9% and 2.32 ± 0.57 m/s, and 61.3 ± 21.29% and 4.36 ± 1.25)m/s, respectively. For the parameters of elastography, "AREA%"and SWV demonstrated significant differences between groups (p=0.002). AREA% was positively correlated with SWV with a correlation coefficient of 0.809 (P<0.001).
  
  
  CONCLUSIONS
  Stiffness of different lymph node diseases in patients may differ. Elastography can evaluate changes sensitively and provide valuable information to doctors. The study proved that the VTIQ elastography technique can play an important role in differential diagnosis of lymph nodes.
authors.affiliation: Department of Ultrasonography, the Affiliated Hospital of Qingdao University, Qingdao, China E-mail : zjp11_01@163.com.
authors.forename: Jun-Peng
authors.initials: JP
authors.lastname: Zhang
authors.forename: Hua-Yan
authors.initials: HY
authors.lastname: Liu
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Ning
authors.forename: Jing
authors.initials: J
authors.lastname: Chong
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Sun
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D002291:Carcinoma, Papillary; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D055815:Young Adult