title: [A tribute to the memory of the illustrious maestro and academic Dr. Rafael Méndez Martínez, pioneer in the pharmacological studies of digitalis and digitalis glycosides].
abstract: Since the end of the XVIII century, digitalis glycosides were employed in heart failure. They were considered initially as diuretics and later as cardiotonic agents or as positive inotropics. At the present time there are varied groups of positive inotropic agents, which have a beneficial action on the failing human myocardium. For example, the beta adrenergics, the phosphodiesterase III inhibitors such as milrinone, or the sensibilizers of myocardial proteins to Ca++ such as levosimendan and omecamtiv mecarbil. However, following the opinion of distinguished cardiologists, in the case of heart failure associated to atrial fibrillation, digitalis cannot be substituted.
authors.affiliation: Departamento de Farmacología, Instituto Nacional de Cardiología «Ignacio Chávez», México, D.F., México.
authors.forename: Alfredo
authors.initials: A
authors.lastname: de Micheli Serra
authors.affiliation: Departamento de Farmacología, Instituto Nacional de Cardiología «Ignacio Chávez», México, D.F., México.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Pastelín Hernández
mesh_terms: D004070:Digitalis; D004071:Digitalis Glycosides / Q000266:history*; D049669:History, 16th Century; D049671:History, 18th Century; D049672:History, 19th Century; D006801:Humans; D008800:Mexico; D010600:Pharmacology / Q000266:history*
chemical_list: D004071:Digitalis Glycosides