title: The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats.
abstract: OBJECTIVE
  The purpose of this study was to determine the interaction effects of aerobic exercise training and vitamin D supplementation on indices of obesity and plasma lipid profiles in ovariectomized (OVX) rats.
  
  
  METHODS
  Forty female Wistar rats were divided into 5 groups: aerobic training (3 days/week for 8 weeks; AT; n = 8), aerobic training and vitamin D supplementation (OVX + AT + Vit D; n = 8), vitamin D supplementation (OVX + Vit D; n = 8), ovariectomized control (OVX + C, n = 8) and SHAM (n = 8). After blood sampling, visceral fat was taken from the abdominal cavity and weighed immediately. Data was statistically analyzed by One-way ANOVA and Repeated measure ANOVA tests with a 0.05 significance level.
  
  
  RESULTS
  Body weight, visceral fat, BMI and food intake decreased significantly in OVX + AT + Vit D (P < 0.001); whereas these variables increased significantly in OVX + C (P < 0.001) and SHAM (P < 0.023) groups. At the end of two-months of follow-up, we observed significant differences in TC, TG, HDL-C, LDL-C, glucose, insulin, and HOMA-IR in all groups.
  
  
  CONCLUSIONS
  It seems that aerobic training with vitamin D, due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles, increased energy expenditure, stimulated insulin exudation and glucose homeostasis, decreased insulin resistance and improved the lipid profile in ovariectomized rats.
authors.affiliation: Department of Physiology, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Parvin
authors.initials: P
authors.lastname: Babaei
authors.affiliation: Department of Sport Physiology, Faculty of physical education and sport sciences, University of Guilan, Rasht, Iran.
authors.forename: Arsalan
authors.initials: A
authors.lastname: Damirchi
authors.affiliation: Department of Sport Physiology, Faculty of physical education and sport sciences, University of Guilan, Rasht, Iran.
authors.forename: Rastegar
authors.initials: R
authors.lastname: Hoseini
keywords: Aerobic Training; Food Intake; Postmenopausal Women; Visceral Fat; Vitamin D; plasma lipid profiles and insulin resistance