title: Pre-hypertension: Is it an inflammatory state?
abstract: Even though several studies have implicated the role of inflammation in the pathogenesis of hypertension and other cardiovascular disease, there are only limited studies about inflammatory markers in prehypertension. The objective of the present article was to review the role of markers like C-reactive protein, interleukin-6, tumor necrosis factor-α and sialic acid in prehypertension. An extensive literature search was made in Pubmed (http://www.ncbi.nlm.nih.gov/pubmed/) using phrases such as prehypertension, inflammation, C-reactive protein, cardiovascular disease, cytokines and sialic acid. Several investigators have reported increased inflammatory markers like C-reactive protein, interleukin-6, tumor necrosis factor-α and sialic acid in prehypertension indicating the role of inflammation in the pathogenesis of prehypertension and its complications. Elevated inflammatory markers may enhance the risk for cardiovascular disease in subjects with prehypertension.
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605 006, India. Electronic address: nandijipmer@gmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Nandeesha
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605 006, India.
authors.forename: Zachariah
authors.initials: Z
authors.lastname: Bobby
authors.affiliation: Department of Clinical Biochemistry, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.
authors.forename: N
authors.initials: N
authors.lastname: Selvaraj
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605 006, India.
authors.forename: Medha
authors.initials: M
authors.lastname: Rajappa
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D058246:Prehypertension / Q000150:complications / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D019158:N-Acetylneuraminic Acid
keywords: C-reactive protein; Cardiovascular disease; Interleukin-6; Prehypertension; Sialic acid; Tumor necrosis factor-α