title: Vinca alkaloids in the therapeutic management of malignant pleural mesothelioma.
abstract: Therapeutic options for malignant pleural mesothelioma (MPM) are limited. Most patients are treated with chemotherapy during the course of their disease. The combination of pemetrexed with a platinum compound is the standard of care in the first-line setting, while no established treatment exists in the second and beyond-line setting. Vinca alkaloids are chemotherapeutic agents that have demonstrated clinical efficacy both as single agents and in combination in a broad spectrum of cancers, including MPM. Vinorelbine has shown activity in MPM patients as neoadjuvant therapy, first-line treatment, and in the second and third-line setting. Vinflunine is a derivative of vinorelbine that has been studied in MPM as first-line agent. While the role of vinca alkaloids in the first-line treatment of MPM seems marginal, treatment with vinorelbine remains a reasonable option for pemetrexed-pretreated patients in clinical practice, based on an acceptable rate of stable disease, confirmed by several trials. Ongoing studies on predictive biomarkers for vinorelbine will hopefully be able to individualize treatment, increasing response rates and survival outcomes.
authors.affiliation: Department of Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy. Electronic address: giovanni_luca.ceresoli@gavazzeni.it.
authors.forename: Giovanni Luca
authors.initials: GL
authors.lastname: Ceresoli
authors.affiliation: Department of Oncology, Humanitas Cancer Center, Rozzano (Milan), Italy. Electronic address: paolo.zucali@cancercenter.humanitas.it.
authors.forename: Paolo Andrea
authors.initials: PA
authors.lastname: Zucali
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008654:Mesothelioma / Q000188:drug therapy*; D000086002:Mesothelioma, Malignant; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D000068437:Pemetrexed / Q000008:administration & dosage; D010997:Pleural Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014748:Vinca Alkaloids; D000077235:Vinorelbine; D000093542:Gemcitabine
chemical_list: D009944:Organoplatinum Compounds; D014748:Vinca Alkaloids; D000068437:Pemetrexed; D000077150:Oxaliplatin; D003841:Deoxycytidine; C111217:vinflunine; D014747:Vinblastine; D016190:Carboplatin; D002945:Cisplatin; D000077235:Vinorelbine; D000093542:Gemcitabine
keywords: Chemotherapy; Malignant pleural mesothelioma; Vinca alkaloids; Vinflunine; Vinorelbine