title: Morphology and Immunohistochemical Phenotype of the Thymus in Secondary Immunodeficiency.
abstract: The thymus of outbred male rats 5 months after splenectomy (experimental secondary immunodeficiency) was studied by common histological and immunohistochemical methods using monoclonal and polyclonal antibodies to CD3, CD30, CD68, synaptophysin, to S100, p53, bcl-2, and Ki-67 proteins. Removal of the spleen led to acute involution of the thymic parenchyma, which was replaced by the adipose tissue and was associated with restructuring of the thymopoietic and nonthymopoietic components of the gland, changes in cellular composition and antigenic phenotype of the lobular cortical and medullary matter, and by reduction of cell proliferation.
authors.affiliation: Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia. glebstr@mail.ru.
authors.forename: G Yu
authors.initials: GY
authors.lastname: Struchko
authors.affiliation: Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Merkulova
authors.affiliation: Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Moskvichev
authors.affiliation: Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Kostrova
authors.affiliation: Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Mikhailova
authors.affiliation: Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University, Cheboksary, Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Drandrova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D002452:Cell Count; D049109:Cell Proliferation; D007150:Immunohistochemistry; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D008297:Male; D010641:Phenotype; D051381:Rats; D013156:Splenectomy; D060168:Thymocytes / Q000473:pathology / Q000502:physiology; D013950:Thymus Gland / Q000378:metabolism* / Q000473:pathology*
keywords: immunodeficiency; involution; splenectomy; thymus