title: Fatal Cases of Bloodstream Infection by Fusarium solani and Review of Published Literature.
abstract: Fusarium species are ubiquitously present in environment and are well known as human pathogens with high mortality rate in immunocompromised patients. We report here two cases where immunocompromised patients developed fatal bloodstream infections by this organism. Isolates were further identified by ITS1 region sequencing which confirmed them as Fusarium solani. Antifungal susceptibility testing was done following CLSI M38-A2 guidelines to amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and micafungin. Both patients had a fatal outcome and expired of septic shock. Therefore, identification up to species level is of utmost importance as that helps in directing the management of the patient thereby leading to a favourable outcome.
authors.affiliation: Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Yubhisha
authors.initials: Y
authors.lastname: Dabas
authors.affiliation: Department of Medical Oncology, BRA-IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
authors.affiliation: Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India. immaxess@gmail.com.
authors.forename: Immaculata
authors.initials: I
authors.lastname: Xess
mesh_terms: D000293:Adolescent; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001483:Base Sequence; D021901:DNA, Intergenic / Q000235:genetics; D015725:Fluconazole / Q000627:therapeutic use; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D060585:Fusariosis / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality*; D005670:Fusarium / Q000187:drug effects*; D006801:Humans; D016867:Immunocompromised Host; D007194:India; D008297:Male; D008826:Microbial Sensitivity Tests; D017422:Sequence Analysis, DNA; D012772:Shock, Septic / Q000382:microbiology* / Q000401:mortality
chemical_list: D000935:Antifungal Agents; D021901:DNA, Intergenic; D000666:Amphotericin B; D015725:Fluconazole
keywords: Antifungal susceptibility testing; Bloodstream infection; Fusarium solani; ITS1 DNA sequencing; India