title: In vitro activity of Aloe vera inner gel against microorganisms grown in planktonic and sessile phases.
abstract: The failure of traditional antimicrobial treatments is becoming a worldwide problem. The use of Aloe vera is of particular interest for its role as curative agent and its efficacy in complementary therapies for a variety of illnesses. This study evaluated the antimicrobial activity of A. vera inner gel against a panel of microorganisms, Gram-positive and -negative bacteria, and Candida albicans. In addition to A. vera inner gel being used in the treatment of peptic ulcers, in dermatological treatments, and wound healing, it was also tested on the sessile phase of clinical Helicobacter pylori strains (including multi-drug-resistant strains) and on planktonic and sessile phase of Staphylococcus aureus/Pseudomonas aeruginosa clinical isolates from venous leg ulcers.A. vera inner gel expresses its prevalent activity against Gram-negative bacteria and C. albicans in respect to Gram-positive bacteria. The results of the A. vera antibiofilm activity showed a decrease of the produced biomass in a concentration-dependent-way, in each analyzed microorganism. The data obtained show that A. vera inner gel has both an antimicrobial and antibiofilm activity suggesting its potential use for the treatment of microbial infections, in particular for H. pylori gastric infection, especially in case of multi-drug-resistance, as well as for an effective wound dressing.
authors.affiliation: Department of Pharmacy, University "G. d'Annunzio", Chieti-Pescara, Chieti, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Cataldi
authors.affiliation: Department of Pharmacy, University "G. d'Annunzio", Chieti-Pescara, Chieti, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Di Bartolomeo
authors.affiliation: Department of Pharmacy, University "G. d'Annunzio", Chieti-Pescara, Chieti, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Di Campli
authors.affiliation: Department of Pharmaceutical Sciences and Health Products, University of Messina, Polo Annunziata, Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Nostro
authors.affiliation: Department of Pharmacy, University "G. d'Annunzio", Chieti-Pescara, Chieti, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cellini
authors.affiliation: Department of Pharmacy, University "G. d'Annunzio", Chieti-Pescara, Chieti, Italy m.digiulio@unich.it.
authors.forename: M
authors.initials: M
authors.lastname: Di Giulio
mesh_terms: D000504:Aloe; D018441:Biofilms / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005782:Gels; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D010933:Plankton / Q000382:microbiology*
chemical_list: D005782:Gels
keywords: Aloe vera inner gel; antimicrobial activity; microbial biofilm; multi-drug-resistant Helicobacter pylori