title: Programming Bacteriophages by Swapping Their Specificity Determinants.
abstract: Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.
authors.affiliation: Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Moran G
authors.initials: MG
authors.lastname: Goren
authors.affiliation: Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Ido
authors.initials: I
authors.lastname: Yosef
authors.affiliation: Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: ehudq@post.tau.ac.il.
authors.forename: Udi
authors.initials: U
authors.lastname: Qimron
mesh_terms: D001419:Bacteria / Q000821:virology*; D001424:Bacterial Infections / Q000382:microbiology* / Q000628:therapy*; D001435:Bacteriophages / Q000254:growth & development*; D001691:Biological Therapy / Q000379:methods*; D000529:Complementary Therapies / Q000379:methods*; D006801:Humans
keywords: bacteriophage adsorption; host-range expansion; host-recognition ligand; shaping bacterial microbiome