title: Nutritional controversies in critical care: revisiting enteral glutamine during critical illness and injury.
abstract: OBJECTIVE
  This article examines some of the articles that inspired recent changes to critical care guidelines related to glutamine in enteral nutrition.
  
  
  RESULTS
  Two recent multicenter randomized controlled trials involving enteral glutamine have reported increased mortality rates in groups of mechanically ventilated adult patients, while demonstrating no additional benefits to other outcomes, such as nosocomial infections.
  
  
  CONCLUSIONS
  Recent studies suggest that enteral glutamine supplementation may not provide significant clinical benefits to adult patients on mechanical ventilation with multiple organ failure, but more information is still needed when attempting to apply these results to other groups of critical care patients.
authors.affiliation: aDivision of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, University of Arizona, Tucson, Arizona, USA bSection for Surgical Research, Clinical Division of General Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
authors.forename: John A
authors.initials: JA
authors.lastname: Stroster
authors.forename: Selman
authors.initials: S
authors.lastname: Uranues
authors.forename: Rifat
authors.initials: R
authors.lastname: Latifi
mesh_terms: D003422:Critical Care / Q000379:methods* / Q000592:standards; D016638:Critical Illness / Q000628:therapy*; D004750:Enteral Nutrition / Q000379:methods* / Q000592:standards; D005973:Glutamine / Q000008:administration & dosage*; D006801:Humans; D015337:Multicenter Studies as Topic; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D012121:Respiration, Artificial / Q000295:instrumentation* / Q000592:standards
chemical_list: D005973:Glutamine