title: Mu opioid receptor polymorphism, early social adversity, and social traits.
abstract: A polymorphism in the mu opioid receptor gene OPRM1 (rs1799971) has been investigated for its role in sensitivity to social contexts. Evidence suggests that the G allele of this polymorphism is associated with higher levels of sensitivity. This study tested for main effects of the polymorphism and its interaction with a self-report measure of childhood adversity as an index of negative environment. Outcomes were several personality measures relevant to social connection. Significant interactions were obtained, such that the negative impact of childhood adversity on personality was greater among G carriers than among A homozygotes on measures of agreeableness, interdependence, anger proneness, hostility, authentic pride, life engagement, and an index of (mostly negative) feelings coloring one's world view. Findings support the role of OPRM1 in sensitivity to negative environments. Limitations are noted, including the lack of a measure of advantageous social environment to assess sensitivity to positive social contexts.
authors.affiliation: a Department of Psychology , University of Miami , Coral Gables , FL , USA.|b Center for Advanced Study in the Behavioral Sciences , Stanford University , Stanford , CA , USA.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Carver
authors.affiliation: b Center for Advanced Study in the Behavioral Sciences , Stanford University , Stanford , CA , USA.|c Department of Psychology , University of California , Berkeley , CA , USA.
authors.forename: Sheri L
authors.initials: SL
authors.lastname: Johnson
authors.affiliation: a Department of Psychology , University of Miami , Coral Gables , FL , USA.|b Center for Advanced Study in the Behavioral Sciences , Stanford University , Stanford , CA , USA.
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D005500:Follow-Up Studies; D059647:Gene-Environment Interaction; D060005:Genotyping Techniques; D006579:Heterozygote; D006801:Humans; D016014:Linear Models; D010551:Personality / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017450:Receptors, Opioid, mu / Q000235:genetics*; D012306:Risk; D057566:Self Report; D012919:Social Behavior; D066252:Sociological Factors; D013315:Stress, Psychological / Q000235:genetics*; D055815:Young Adult
chemical_list: C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu
keywords: A118G; Asn40Asp; OPRM1; mu opioid receptor gene; rs1799971; social traits