title: Carbohydrate-Based Initiators for the Cationic Ring-Opening Polymerization of 2-Ethyl-2-Oxazoline.
abstract: The advancement in the field of living and controlled polymerization techniques provides the opportunity for careful bottom-up design of polymers for biomedical applications according to their specific needs. This contribution describes the detailed methodology to functionalize poly(2-ethyl-2-oxazoline), a polymer with properties very similar to polyethylene glycol, in a stereo-selective manner with a range of carbohydrates that can serve as biological targeting units. The obtained building blocks can subsequently be applied for the synthesis of more complex polymeric architectures.
authors.affiliation: Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743, Jena, Germany.|Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Weber
authors.affiliation: Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743, Jena, Germany.|Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Gottschaldt
authors.affiliation: Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, 9000, Ghent, Belgium.
authors.forename: Richard
authors.initials: R
authors.lastname: Hoogenboom
authors.affiliation: Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743, Jena, Germany. ulrich.schubert@uni-jena.de.|Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany. ulrich.schubert@uni-jena.de.
authors.forename: Ulrich S
authors.initials: US
authors.lastname: Schubert
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis*; D011073:Polyamines / Q000138:chemical synthesis*; D058105:Polymerization
chemical_list: D002241:Carbohydrates; D006001:Glycoconjugates; D011073:Polyamines; C511916:poly(2-ethyl-2-oxazoline)
keywords: Carbohydrate; Cationic polymerization; End-functional polymers; Glycopolymers; Poly(2-oxazoline); Ring-opening polymerization; Telechelic polymers