title: Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects.
abstract: Metal oxide nanoparticles (MO-NPs) are the multidisciplinary nano-scaled molecules which are being used in the diagnosis and treatment of the challenging diseases including cancer. Evidence suggest that antimicrobial formulations in the form of MO-NPs can be possibly used as effective antimicrobial agents. In addition, MO-NPs are known to target various cellular signaling pathways associated with apoptosis, angiogenesis, metastasis and inflammation of cancer. In combination with other chemotherapeutic/anticancer agents, MO-NPs not only increase their bioavailability and efficacy but also lower down the requirement of active dosages. To date, to our knowledge there is no single comprehensive report on cellular and molecular interactions of MO-NPs which have been well elaborated in this review. Also we highlight various action mechanisms through which MO-NPs act as antimicrobial, anticancer, antioxidant and anti-inflammatory agents.
authors.affiliation: Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana 133207, India. Electronic address: hardeep.biotech@gmail.com.
authors.forename: Hardeep Singh
authors.initials: HS
authors.lastname: Tuli
authors.affiliation: Department of Histopathology, PGIMER, Chandigarh, Punjab 160012, India.
authors.forename: Dharambir
authors.initials: D
authors.lastname: Kashyap
authors.affiliation: Department of Hepatology, PGIMER, Chandigarh, Punjab 160012, India.
authors.forename: Simranjeet Kaur
authors.initials: SK
authors.lastname: Bedi
authors.affiliation: Department of Electronic Science, Kurukshetra University, Kurukshetra, Haryana 136119, India.
authors.forename: Pardeep
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Biochemistry, Kurukshetra University, Kurukshetra, Haryana 136119, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kumar
authors.affiliation: Department of Biological Sciences, R.D. University, Jabalpur, Madhya Pradesh 482001, India.
authors.forename: Sardul Singh
authors.initials: SS
authors.lastname: Sandhu
mesh_terms: D000818:Animals; D006801:Humans; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D008670:Metals / Q000378:metabolism / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010087:Oxides / Q000378:metabolism* / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D008670:Metals; D010087:Oxides
keywords: Anti-cancer; Anti-inflammatory; Anti-microbial; Anti-oxidant; Metal oxide; Nanotechnology