title: Association of Body Mass Index Categories with Disease Activity and Radiographic Joint Damage in Rheumatoid Arthritis: A Systematic Review and Metaanalysis.
abstract: OBJECTIVE
  Obesity and overweight are increasing conditions. Adipose tissue with proinflammatory properties could be involved in rheumatoid arthritis (RA) activity and radiographic progression. This study aims to investigate the influence of overweight and obesity on RA activity and severity.
  
  
  METHODS
  We conducted a systematic review and metaanalysis to assess the association of body mass index (BMI) categories with the Disease Activity Score in 28 joints (DAS28), functional disability [Health Assessment Questionnaire (HAQ)], and radiographic joint damage in patients with RA. We searched Medline through PubMed, EMBASE, and the Cochrane Database of Systematic Reviews for all studies assessing DAS28, HAQ, or/and radiographic damage according to predefined BMI groups.
  
  
  RESULTS
  Among the 737 citations retrieved, 58 articles met the inclusion criteria and 7 were included in the metaanalysis. DAS28 was higher in obese (BMI > 30 kg/m(2)) than non-obese (BMI ≤ 30 kg/m(2)) patients (mean difference 0.14, 95% CI 0.01-0.27, p = 0.04, I(2) = 0%). HAQ score was also higher among obese patients (mean difference 0.10, 95% CI 0.01-0.19, p = 0.03, I(2) = 0%). Radiographic joint damage was negatively associated with obesity (standardized mean difference -0.15, 95% CI -0.29 to -0.02, p = 0.03, I(2) = 38%).
  
  
  CONCLUSIONS
  Obesity in RA is associated with increased DAS28 and HAQ score and with lower radiographic joint damage. These associations mainly result from an increase of subjective components of the DAS28 (total joint count and global health assessment) in obese patients. Conflicting results were reported concerning inflammation markers (C-reactive protein and erythrocyte sedimentation rate).
authors.affiliation: From the Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; Institut of Molecular Genetic of Montpellier, Unité Mixte de Recherche n. 5535 (UMR5535), Montpellier; Rheumatology Department, Hôpital Pellegrin, Bordeaux, France.C. Vidal, MD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; T. Barnetche, PhD, Rheumatology Department, Hôpital Pellegrin; J. Morel, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; B. Combe, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; C. Daïen, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535.
authors.forename: Celine
authors.initials: C
authors.lastname: Vidal
authors.affiliation: From the Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; Institut of Molecular Genetic of Montpellier, Unité Mixte de Recherche n. 5535 (UMR5535), Montpellier; Rheumatology Department, Hôpital Pellegrin, Bordeaux, France.C. Vidal, MD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; T. Barnetche, PhD, Rheumatology Department, Hôpital Pellegrin; J. Morel, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; B. Combe, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; C. Daïen, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535.
authors.forename: Thomas
authors.initials: T
authors.lastname: Barnetche
authors.affiliation: From the Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; Institut of Molecular Genetic of Montpellier, Unité Mixte de Recherche n. 5535 (UMR5535), Montpellier; Rheumatology Department, Hôpital Pellegrin, Bordeaux, France.C. Vidal, MD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; T. Barnetche, PhD, Rheumatology Department, Hôpital Pellegrin; J. Morel, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; B. Combe, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; C. Daïen, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535.
authors.forename: Jacques
authors.initials: J
authors.lastname: Morel
authors.affiliation: From the Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; Institut of Molecular Genetic of Montpellier, Unité Mixte de Recherche n. 5535 (UMR5535), Montpellier; Rheumatology Department, Hôpital Pellegrin, Bordeaux, France.C. Vidal, MD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; T. Barnetche, PhD, Rheumatology Department, Hôpital Pellegrin; J. Morel, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; B. Combe, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; C. Daïen, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535.
authors.forename: Bernard
authors.initials: B
authors.lastname: Combe
authors.affiliation: From the Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; Institut of Molecular Genetic of Montpellier, Unité Mixte de Recherche n. 5535 (UMR5535), Montpellier; Rheumatology Department, Hôpital Pellegrin, Bordeaux, France.C. Vidal, MD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University; T. Barnetche, PhD, Rheumatology Department, Hôpital Pellegrin; J. Morel, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; B. Combe, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535; C. Daïen, MD, PhD, Rheumatology Department, Hôpital Lapeyronie, Montpellier I University, and Institut of Molecular Genetic of Montpellier, UMR5535. c-daien@chu-montpellier.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Daïen
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology*; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents
keywords: BODY MASS INDEX; OBESITY; RHEUMATOID ARTHRITIS