title: Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities.
abstract: The development of cellular reprogramming methods to generate human induced pluripotent stem cells (iPSC) has led to the establishment of lines from hundreds of patients with a variety of neurologic and psychiatric diseases. One of the fundamental powers of iPSC technology lies in the competency of these cells to be directed to become any cell type in the body, thus allowing researchers to examine disease mechanisms and identify and test novel therapeutics in relevant cell types. The field has now exited the phase of 'proof-of-principle' studies showing the potential of the model systems, and it has now entered an exciting new era where iPSC studies are contributing to the field's understanding of mechanisms of disease. Here, we describe the challenges of iPSC modeling of neuropsychiatric disorders, and highlight studies where some of these challenges have been addressed to provide novel insights into disease mechanisms.
authors.affiliation: Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: tyoung@rics.bwh.harvard.edu.
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Young-Pearse
authors.affiliation: Department of Molecular Biology, Cell Biology and Biochemistry (MCB), and Institute for Brain Science, Brown University, 70 Ship Street, Providence, RI 02912, USA; Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital and Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02912, USA. Electronic address: Eric_Morrow@brown.edu.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Morrow
mesh_terms: D000818:Animals; D000067877:Autism Spectrum Disorder / Q000378:metabolism* / Q000503:physiopathology; D001321:Autistic Disorder / Q000378:metabolism* / Q000503:physiopathology; D000067470:Cellular Reprogramming Techniques; D003712:Dendrites / Q000378:metabolism / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism* / Q000502:physiology; D008133:Long QT Syndrome / Q000378:metabolism* / Q000503:physiopathology; D008959:Models, Neurological; D009457:Neuroglia / Q000378:metabolism / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D010641:Phenotype; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000378:metabolism* / Q000503:physiopathology; D013569:Synapses / Q000378:metabolism / Q000502:physiology; D013576:Syndactyly / Q000378:metabolism* / Q000503:physiopathology