title: A Pilot Comparative Study of 26 Biochemical Markers in Seminal Plasma and Serum in Infertile Men.
abstract: BACKGROUND
  The relationships of the biochemical components in seminal plasma and serum, and their origins and physiological effects in male reproductive system have been poorly understood.
  
  
  METHODS
  Based on the calibration and quality control measures, 26 biochemical markers, in seminal plasma and serum samples from 36 male infertility patients with nonazoospermia were detected and compared.
  
  
  RESULTS
  Only PA was undetectable in all seminal plasma samples. There were significant differences of all other 24 biochemical markers in seminal plasma and serum (P < 0.05) except for UA (P = 0.214). There were rich proteins in seminal plasma, and globulin accounted for about 90%. There were also abundant enzymes in seminal plasma, and the activities of ALT, AST, AKP, GGT, LDH, CK, and αHBDH in seminal plasma were significantly higher than those in serum while ADA was inversely lower. There were relatively low levels of Glu, TG, TC, and hsCRP in seminal plasma, but Glu was undetectable in 8 of 36 cases.
  
  
  CONCLUSIONS
  The differences of the levels of biochemical markers in seminal plasma and serum might be associated with the selective secretion of testis, epididymis and male accessory glands, and the specific environment needed for sperm metabolism and function maintenance.
authors.affiliation: Department of Laboratory Science, Nanjing Hospital, Jiangsu Corps, The Armed Police Force, PLA, Nanjing 210028, China.
authors.forename: Rui-Xiang
authors.initials: RX
authors.lastname: Feng
authors.affiliation: Department of Laboratory Science, Nanjing Hospital, Jiangsu Corps, The Armed Police Force, PLA, Nanjing 210028, China.
authors.forename: Jin-Chun
authors.initials: JC
authors.lastname: Lu
authors.affiliation: Department of Laboratory Science, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China.
authors.forename: Hong-Ye
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: Jiangsu Family Planning Research Institute, Nanjing 210036, China.
authors.forename: Nian-Qing
authors.initials: NQ
authors.lastname: Lü
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D015331:Cohort Studies; D006801:Humans; D007248:Infertility, Male / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism*; D008297:Male; D010865:Pilot Projects; D012661:Semen / Q000737:chemistry*
chemical_list: D015415:Biomarkers