title: [Pharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity].
abstract: Pharmacokinetic properties of imidazobenzimidazole derivative compound RU-1205 were investigated after subcutaneous administration to rabbits as a substance and a dosage form (lyophilisates for injection) at a dose of 25 mg/kg. The lyophilisate was characterized by high values of the relative bioavailability. In tests, the "hot plate" and "vinegar cramps" the dosage form and the substance exhibited the same analgesic effect.
authors.affiliation: Volgograd State Medical University, Volgograd, Russia; Volgograd Medical Research Center, Volgograd, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.affiliation: Volgograd State Medical University, Volgograd, Russia; Volgograd Medical Research Center, Volgograd, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Smirnova
authors.affiliation: Volgograd State Medical University, Volgograd, Russia.
authors.forename: O U
authors.initials: OU
authors.lastname: Grechko
authors.affiliation: Volgograd State Medical University, Volgograd, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Raschenko
authors.affiliation: Volgograd State Medical University, Volgograd, Russia.
authors.forename: D M
authors.initials: DM
authors.lastname: Shtareva
authors.affiliation: Institute of Physical and Organic Chemistry, South Federal University, Rostov-on-Don, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001562:Benzimidazoles / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D005612:Freeze Drying; D007279:Injections, Subcutaneous; D051379:Mice; D009025:Morpholines / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D009120:Muscle Cramp / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D010146:Pain / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D011817:Rabbits; D017473:Receptors, Opioid, kappa / Q000819:agonists / Q000378:metabolism
chemical_list: C586860:9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo(1,2-alpha)benzimidazole; D000700:Analgesics; D001562:Benzimidazoles; D009025:Morpholines; D017473:Receptors, Opioid, kappa; D019342:Acetic Acid
keywords: analgesia; benzimidazols; compound RU-1205; injection dosage form; pharmacodinamics; pharmacokinetics