title: Modulation of wound healing in glaucoma surgery.
abstract: Glaucoma is a neurodegenerative disease and is the second most important cause of irreversible blindness. Filtration surgery remains the most effective therapy to reduce intraocular pressure in glaucoma patients. The main determinant of long-term surgical success is the healing response. Excessive postoperative wound healing with subsequent fibrosis may lead to obstruction of the created channel which frequently results in early surgical failure and consequent progression of visual field loss. Preoperative use of antimitotics, such as mitomycin-C and 5-fluorouracyl, effectively improves surgery outcome. However, the use of these nonspecific antiproliferative agents can be associated with severe side effects. This review provides an overview of the most important efforts that have been made to explore novel, more specific, and safer agents to prevent glaucoma filtration failure and improve surgery outcome.
authors.affiliation: Department of Neurosciences, Laboratory of Ophthalmology, KU Leuven, Leuven, Belgium.
authors.forename: Sarah
authors.initials: S
authors.lastname: Van de Velde
authors.affiliation: Department of Neurosciences, Laboratory of Ophthalmology, KU Leuven, Leuven, Belgium.
authors.forename: Tine
authors.initials: T
authors.lastname: Van Bergen
authors.affiliation: Department of Neurosciences, Laboratory of Ophthalmology, KU Leuven, Leuven, Belgium; Department of Ophthalmology, University Hospitals Leuven (UZ Leuven), Leuven, Belgium.
authors.forename: Evelien
authors.initials: E
authors.lastname: Vandewalle
authors.affiliation: Research Group of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium.
authors.forename: Lieve
authors.initials: L
authors.lastname: Moons
authors.affiliation: Department of Neurosciences, Laboratory of Ophthalmology, KU Leuven, Leuven, Belgium; Department of Ophthalmology, University Hospitals Leuven (UZ Leuven), Leuven, Belgium. Electronic address: ingeborg.stalmans@uzleuven.be.
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Stalmans
mesh_terms: D005355:Fibrosis / Q000517:prevention & control; D018463:Filtering Surgery / Q000009:adverse effects*; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control*; D014945:Wound Healing / Q000502:physiology*
keywords: Fibrosis; Glaucoma filtration surgery; Wound healing