title: Gene regulation by long purine tracks in brain related diseases.
abstract: Purine repeats are randomly distributed in the human genome, however, they show potential role in the transcriptional deregulation of genes. Presence of long tracks of purine repeats in the genome can disturb its integrity and interfere with the cellular behavior by introducing mutations and/or triple stranded structure formation in DNA. Our data revealed interesting finding that a majority of genes carrying purine repeats, of length n≥200, were down regulated and found to be linked with several brain related diseases [1]. The unique feature of the purine repeats found in the present study clearly manifests their significant application in developing therapeutics for neurological diseases.
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India ; School of Sciences, Noida International University, Gautam Budh Nagar, 203201 Uttar Pradesh, India.
authors.forename: Himanshu Narayan
authors.initials: HN
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Moganty R
authors.initials: MR
authors.lastname: Rajeswari
keywords: Brain disease; Gene regulation; Human genome; Purine repeat