title: When Physics Takes Over: BAR Proteins and Membrane Curvature.
abstract: Cell membranes become highly curved during membrane trafficking, cytokinesis, infection, immune response, or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their intrinsically curved and anisotropic shape are involved in many of these processes, but with a large spectrum of modes of action. In vitro experiments and multiscale computer simulations have contributed in identifying a minimal set of physical parameters, namely protein density on the membrane, membrane tension, and membrane shape, that control how bound BAR domain proteins behave on the membrane. In this review, we summarize the multifaceted coupling of BAR proteins to membrane mechanics and propose a simple phase diagram that recapitulates the effects of these parameters.
authors.affiliation: Department of Chemistry, Institute for Biophysical Dynamics, James Franck Institute and Computation Institute, The University of Chicago, 5735 S Ellis Avenue, Chicago, IL 60637, USA; Institut Curie, Centre de Recherche, F-75248 Paris, France.
authors.forename: Mijo
authors.initials: M
authors.lastname: Simunovic
authors.affiliation: Department of Chemistry, Institute for Biophysical Dynamics, James Franck Institute and Computation Institute, The University of Chicago, 5735 S Ellis Avenue, Chicago, IL 60637, USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Voth
authors.affiliation: Université Paris Diderot, F-75205 Paris, France; CNRS, Matière et Systèmes Complexes, UMR 7057, F-75205 Paris, France.
authors.forename: Andrew
authors.initials: A
authors.lastname: Callan-Jones
authors.affiliation: Institut Curie, Centre de Recherche, F-75248 Paris, France; CNRS, PhysicoChimie Curie, UMR 168, F-75248 Paris, France; Université Pierre et Marie Curie, F-75252 Paris, France. Electronic address: patricia.bassereau@curie.fr.
authors.forename: Patricia
authors.initials: P
authors.lastname: Bassereau
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D048430:Cell Shape / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology*; D055585:Physical Phenomena; D017434:Protein Structure, Tertiary / Q000502:physiology; D021381:Protein Transport / Q000502:physiology
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; C075637:amphiphysin
keywords: BAR proteins; curvature sensing; membrane curvature; membrane scission; membrane shaping; protein scaffold