title: Systemic Problems: A perspective on stem cell aging and rejuvenation.
abstract: This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.
authors.affiliation: Department of Bioengineering, UC Berkeley; QB3, CA 94709, USA.
authors.forename: Irina M
authors.initials: IM
authors.lastname: Conboy
authors.affiliation: Department of Bioengineering, UC Berkeley; QB3, CA 94709, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Conboy
authors.affiliation: Department of Bioengineering, UC Berkeley; QB3, CA 94709, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Rebo
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D016922:Cellular Senescence; D055412:Growth Differentiation Factors / Q000378:metabolism; D006801:Humans; D010227:Parabiosis; D012060:Rejuvenation / Q000502:physiology*
chemical_list: D019485:Bone Morphogenetic Proteins; C492266:GDF11 protein, human; D055412:Growth Differentiation Factors
keywords: aging; neurogenesis; parabiosis; rejuvenation; stem cells