title: [Large vessel involvement in ANCA-associated vasculitis: Report of one case].
abstract: Pauci-immune glomerulonephritis in systemic vasculitides usually have anti-neuthrophil cytoplasmic antibodies (ANCA). However, vasculitides of large vessels such as Takayasu's and giant cell (temporal) arteritis do not. Exceptionally ANCA(+) small vessel vasculitides are associated with large vessel vasculitis. It may be a coincidence or both vasculitides have a common pathogenesis. We report a 30 years old woman on hemodialysis due to a chronic glomerulonephritis ANCA(+) diagnosed nine years ago. Eight years later, she presented with an aortitis with severe stenosis of distal aorta and vasculitis of left subclavian artery. She was treated with adrenal steroids and cyclophosphamide. During the ensuing five years she has been stable and without signs of reactivation of the disease.
authors.forename: Jorge
authors.initials: J
authors.lastname: Vega
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Guarda
mesh_terms: D000328:Adult; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications / Q000188:drug therapy*; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000188:drug therapy*; D001025:Aortitis / Q000175:diagnosis / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D051437:Renal Insufficiency / Q000150:complications; D013256:Steroids / Q000627:therapeutic use*; D013625:Takayasu Arteritis / Q000188:drug therapy
chemical_list: D013256:Steroids; D003520:Cyclophosphamide