title: Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation.
abstract: Ferulic acid (FA) has been reported to exhibit protective effects against amyloid-β (Aβ)-induced neurodegeneration in vitro and in vivo. Recently, we developed two water-soluble FA derivatives: 1-feruloyl glycerol and 1-feruloyl diglycerol. In this study, we examined the neuroprotective effects of these water-soluble FA derivatives on Aβ-induced neurodegeneration both in vitro and in vivo. FA and water-soluble FA derivatives inhibited Aβ aggregation and destabilized pre-aggregated Aβ to a similar extent. Furthermore, water-soluble FA derivatives, as well as FA, inhibited Aβ-induced neuronal cell death in cultured neuronal cells. In in vivo experiments, oral administration of water-soluble FA derivatives to mice improved Aβ-induced dysmnesia assessed by contextual fear conditioning test and protected hippocampal neurons against Aβ-induced neurotoxicity. This study provides useful evidence suggesting that water-soluble FA derivatives are expected to be effective neuroprotective agents.
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences , Osaka Prefecture University , Sakai , Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Kikugawa
authors.affiliation: b Department of Biological Science, Graduate School of Science , Osaka Prefecture University , Sakai , Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Tsutsuki
authors.affiliation: b Department of Biological Science, Graduate School of Science , Osaka Prefecture University , Sakai , Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ida
authors.affiliation: c Division of Veterinary Science, Graduate School of Life Environmental Sciences , Osaka Prefecture University , Izumisano , Japan.
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Nakajima
authors.affiliation: b Department of Biological Science, Graduate School of Science , Osaka Prefecture University , Sakai , Japan.
authors.forename: Hideshi
authors.initials: H
authors.lastname: Ihara
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences , Osaka Prefecture University , Sakai , Japan.
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D016923:Cell Death / Q000502:physiology*; D003373:Coumaric Acids / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000166:cytology*; D012995:Solubility; D014867:Water
chemical_list: D016229:Amyloid beta-Peptides; D003373:Coumaric Acids; D014867:Water; C004999:ferulic acid
keywords: Alzheimer’s disease; amyloid-β; ferulic acid; neuroprotective agent