title: TGR5 and Immunometabolism: Insights from Physiology and Pharmacology.
abstract: In the past decade substantial progress has been made in understanding how the insurgence of chronic low-grade inflammation influences the physiology of several metabolic diseases. Tissue-resident immune cells have been identified as central players in these processes, linking inflammation to metabolism. The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages, and its activation mediates potent anti-inflammatory effects. Herein, we summarize recent advances in TGR5 research, focusing on the downstream effector pathways that are modulated by TGR5 activators, and on its therapeutic potential in inflammatory and metabolic diseases.
authors.affiliation: Metabolic Signaling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
authors.forename: Alessia
authors.initials: A
authors.lastname: Perino
authors.affiliation: Metabolic Signaling, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. Electronic address: kristina.schoonjans@epfl.ch.
authors.forename: Kristina
authors.initials: K
authors.lastname: Schoonjans
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000276:immunology / Q000378:metabolism / Q000502:physiology*
chemical_list: D001647:Bile Acids and Salts; C473772:GPBAR1 protein, human; C513561:Gpbar1 protein, mouse; D043562:Receptors, G-Protein-Coupled
keywords: TGR5; bile acids; inflammation; macrophages; metabolism