title: Mild cognitive impairment: an update in Parkinson's disease and lessons learned from Alzheimer's disease.
abstract: Cognitive dysfunction is an important focus of research in Parkinson's disease (PD) and Alzheimer's disease (AD). While the concept of amnestic mild cognitive impairment (MCI) as a prodrome to AD has been recognized for many years, the construct of MCI in PD is a relative newcomer with recent development of diagnostic criteria, biomarker research programs and treatment trials. Controversies and challenges, however, regarding PD-MCI's definition, application, heterogeneity and different trajectories have arisen. This review will highlight current research advances and challenges in PD-MCI. Furthermore, lessons from the AD field, which has witnessed an evolution in MCI/AD definitions, relevant advances in biomarker research and development of disease-modifying and targeted therapeutic trials will be discussed.
authors.affiliation: Rush University Medical Center, Department of Neurological Sciences, Section of Parkinson Disease & Movement Disorders, 1725 W. Harrison Street, Suite 755, Chicago, IL 60612, USA.
authors.forename: Jennifer G
authors.initials: JG
authors.lastname: Goldman
authors.affiliation: Rush University Medical Center, Department of Neurological Sciences & Rush Alzheimer's Disease Center, 600 South Paulina, Suite 1038, Chicago, IL 60612, USA.
authors.forename: Neelum T
authors.initials: NT
authors.lastname: Aggarwal
authors.affiliation: Rush University Medical Center, Department of Neurological Sciences, 1735 W. Harrison Street, Suite 306, Chicago, IL 60612, USA.
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Schroeder
mesh_terms: D000544:Alzheimer Disease / Q000150:complications*; D015415:Biomarkers; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers
keywords: Alzheimer's disease; Parkinson's disease; amnestic; biomarker; cognitive; dementia; diagnostic criteria; executive function; mild cognitive impairment; nonamnestic