title: Disease Burden from Hepatitis B Virus Infection in Guangdong Province, China.
abstract: OBJECTIVE
  To estimate the disease burden and financial burden attributed to hepatitis B virus (HBV) infection in Guangdong Province.
  
  
  METHODS
  Based on the data of incidence, mortality and healthcare cost of HBV-related diseases and other socio-economic data in Guangdong Province, we estimated deaths, disability-adjusted life-years (DALYs) and economic cost for the three HBV-related diseases-hepatitis B, liver cirrhosis and liver cancer-in Guangdong following the procedures developed for the global burden of disease study. Then disease burden and economic cost attributed to HBV infection was estimated.
  
  
  RESULTS
  HBV infection was estimated to have caused 33,600 (95% confidence interval (CI): 29,300-37,800) premature deaths and the loss of 583,200 (95% CI: 495,200-671,100) DALYs in Guangdong in 2005. The greatest loss of deaths and DALYs were from liver cancer. The 45-59 years age group had the greatest burden attributable to HBV infection. The estimated total annual cost of HBV-related diseases in Guangdong was RMB 10.8 (95% CI: 8.7-13.0) billion, the direct and indirect cost were RMB 2.6 (95% CI: 2.1-3.2) and 8.2 (95% CI: 6.6-9.8) billion.
  
  
  CONCLUSIONS
  HBV infection is a great medical challenge as well as a significant economic burden to Guangdong Province. The results suggest that substantial health benefits could be gained by extending effective public health and clinical interventions to reduce HBV infection in Guangdong Province.
authors.affiliation: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. jpengx@163.com.
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. hualianglin@gmail.com.
authors.forename: Hualiang
authors.initials: H
authors.lastname: Lin
authors.affiliation: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. gztt_2002@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. letitiazeng@foxmail.com.
authors.forename: Weilin
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. lixing.echo@foxmail.com.
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Immunization Program, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. shaoxping@tom.com.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Shao
authors.affiliation: Institute of Immunization Program, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. tq_1020@163.com.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Tan
authors.affiliation: Institute of Chronic Non-communicable Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. gdxyj05@21cn.com.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Institute of Chronic Non-communicable Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. xu-yd@163.com.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Xu
authors.affiliation: Institute of Immunization Program, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. zhz@cdcp.org.cn.
authors.forename: Huizhen
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. mawj@gdiph.org.cn.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D002681:China / Q000453:epidemiology; D017281:Cost of Illness; D005260:Female; D017048:Health Care Costs / Q000706:statistics & numerical data*; D006509:Hepatitis B / Q000191:economics* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000191:economics* / Q000453:epidemiology; D008113:Liver Neoplasms / Q000191:economics* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged
keywords: DALYs; burden of disease; hepatitis B virus