title: Obesity and Autism.
abstract: OBJECTIVE
  Overweight and obesity are increasingly prevalent in the general pediatric population. Evidence suggests that children with autism spectrum disorders (ASDs) may be at elevated risk for unhealthy weight. We identify the prevalence of overweight and obesity in a multisite clinical sample of children with ASDs and explore concurrent associations with variables identified as risk factors for unhealthy weight in the general population.
  
  
  METHODS
  Participants were 5053 children with confirmed diagnosis of ASD in the Autism Speaks Autism Treatment Network. Measured values for weight and height were used to calculate BMI percentiles; Centers for Disease Control and Prevention criteria for BMI for gender and age were used to define overweight and obesity (≥85th and ≥95th percentiles, respectively).
  
  
  RESULTS
  In children age 2 to 17 years, 33.6% were overweight and 18% were obese. Compared with a general US population sample, rates of unhealthy weight were significantly higher among children with ASDs ages 2 to 5 years and among those of non-Hispanic white origin. Multivariate analyses revealed that older age, Hispanic or Latino ethnicity, lower parent education levels, and sleep and affective problems were all significant predictors of obesity.
  
  
  CONCLUSIONS
  Our results indicate that the prevalence of unhealthy weight is significantly greater among children with ASD compared with the general population, with differences present as early as ages 2 to 5 years. Because obesity is more prevalent among older children in the general population, these findings raise the question of whether there are different trajectories of weight gain among children with ASDs, possibly beginning in early childhood.
authors.affiliation: Center for Spoken Language Understanding, Institute for Development & Disability, Department of Pediatrics; hillali@ohsu.edu.
authors.forename: Alison Presmanes
authors.initials: AP
authors.lastname: Hill
authors.affiliation: Division of General Pediatrics, Doernbecher Children's Hospital; and.
authors.forename: Katharine E
authors.initials: KE
authors.lastname: Zuckerman
authors.affiliation: Department of Psychiatry, Institute for Development & Disability, Oregon Health & Science University, Portland Oregon.
authors.forename: Eric
authors.initials: E
authors.lastname: Fombonne
mesh_terms: D000293:Adolescent; D000067877:Autism Spectrum Disorder / Q000150:complications*; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight / Q000453:epidemiology / Q000209:etiology*; D063766:Pediatric Obesity / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D012307:Risk Factors; D014481:United States