title: Risk Factors and Microbiological Features of Patients Hospitalized for Microbial Keratitis: A 10-Year Study in a Referral Center in Taiwan.
abstract: We conducted a retrospective, cross-sectional study to analyze predisposing factors, clinical features, and microbiological characteristics of patients with microbial keratitis hospitalized over 10 years.The medical records of 558 patients who were diagnosed with microbial keratitis and admitted to Chang Gung Memorial Hospital (CGMH), a referral center in Taiwan, from January 1, 2003 to December 31, 2012 were reviewed. Demographics, predisposing factors, isolated organisms, treatment, and hospital stay were recorded. Yearly trends were tested using a linear-by-linear association.Contact lens wear was the most common predisposing factor (31.4%), followed by ocular and systemic diseases (26.3%) and trauma (23.5%). Contact lens-related infectious keratitis increased year by year (P = 0.011). Pseudomonas aeruginosa was the most commonly isolated organism (28%), followed by fungi (17.6%) and coagulase-negative Staphylococcus (5.4%). Except for Serratia marcescens, the identified organisms did not change over 10 years. Most bacterial infections were controlled using antimicrobial treatment, but more than half of patients with fungal keratitis required surgical interventions. The mean hospital stay was 13.7 ± 11.5 days. Previous ocular surgery, large ulcer size, nontuberculous myycobacteris infection, and surgery during admission were related to prolonged hospital stay.In Taiwan, contact lens-related pseudomonal keratitis remained the most common cause of microbial keratitis in patients hospitalized from 2003 to 2012.
authors.affiliation: From the Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou (T-YL, L-KY, DHM, PYC, H-CL, H-YT, H-CC, S-YC, C-HH); Department of Ophthalmology, Taipei Medical University-Shuang Ho Hospital, New Taipei City (T-YL); College of Medicine, Chang Gung University, Taoyuan (L-KY, D HM, PYC, H-CL, C-C S, H-YT, H-CC, S-YC, C-HH); and Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan (C-CS).
authors.forename: Tzu-Yu
authors.initials: TY
authors.lastname: Lin
authors.forename: Lung-Kun
authors.initials: LK
authors.lastname: Yeh
authors.forename: David Hk
authors.initials: DH
authors.lastname: Ma
authors.forename: Phil Yf
authors.initials: PY
authors.lastname: Chen
authors.forename: Hsin-Chiung
authors.initials: HC
authors.lastname: Lin
authors.forename: Chi-Chin
authors.initials: CC
authors.lastname: Sun
authors.forename: Hsin-Yuan
authors.initials: HY
authors.lastname: Tan
authors.forename: Hung-Chi
authors.initials: HC
authors.lastname: Chen
authors.forename: Shin-Yi
authors.initials: SY
authors.lastname: Chen
authors.forename: Ching-Hsi
authors.initials: CH
authors.lastname: Hsiao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007634:Keratitis / Q000453:epidemiology / Q000382:microbiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult