title: Modeling the Effects of Multiple Intervention Strategies on Controlling Foot-and-Mouth Disease.
abstract: Foot-and-mouth disease (FMD) is a threat to economic security and infrastructure as well as animal health, in both developed and developing countries. We propose and analyze an optimal control problem where the control system is a mathematical model for FMD that incorporates vaccination and culling of infectious animals. The control functions represent the fraction of animals that are vaccinated during an outbreak, infectious symptomatic animals that are detected and culled, and infectious nonsymptomatic animals that are detected and culled. Our aim was to study how these control measures should be implemented for a certain time period, in order to reduce or eliminate FMD in the community, while minimizing the interventions implementation costs. A cost-effectiveness analysis is carried out, to compare the application of each one of the control measures, separately or in combination.
authors.affiliation: Department of Mathematics, University of Zimbabwe, P.O. Box MP 167, Harare, Zimbabwe.
authors.forename: Steady
authors.initials: S
authors.lastname: Mushayabasa
authors.affiliation: Department of Mathematics, University of Zimbabwe, P.O. Box MP 167, Harare, Zimbabwe.
authors.forename: Gift
authors.initials: G
authors.lastname: Tapedzesa
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000821:virology; D003362:Cost-Benefit Analysis; D004196:Disease Outbreaks / Q000517:prevention & control; D005536:Foot-and-Mouth Disease / Q000453:epidemiology* / Q000821:virology; D029544:Foot-and-Mouth Disease Virus / Q000472:pathogenicity; D008962:Models, Theoretical