title: Correlation between the development of calcium oxalate stones and polymorphisms in the fibronectin gene in the Uighur population of the Xinjiang region of China.
abstract: Here, we have investigated the correlation between calcium oxalate stone formation and Fn gene polymorphisms in urinary calculi patients among the Uighur population (Xinjiang region). In this case control study, genomic DNA extracted from the peripheral blood of 129 patients with calcium oxalate stones (patient group) and 94 normal people (control group) was used to genotype polymorphisms in the rs6725958, rs10202709, and rs35343655 sites of the Fn gene by polymerase chain reaction-restriction fragment length polymorphism. Subsequently, the association between different genotypes and susceptibility to calcium oxalate stone formation was compared among the patient and control groups. Single nucleotide polymorphisms (SNPs) were detected in the rs6725958, rs10202709, and rs35343655 sites of the Fn gene among the patient and control groups. The genotype distributions of the three loci complied with the Hardy-Weinberg equilibrium. The results of allele frequencies of the patient/control group for polymorphisms in the rs6725958 site of the Fn gene were C = 179 (69.92%)/119 (63.30%) and A = 77 (30.08%)/69 (36.70%), in the rs10202709 site were C = 245 (95.70%)/176 (93.63%) and T = 11 (4.30%)/12 (6.38%), and in the rs35343655 site of the Fn gene were A = 139 (54.30%)/87 (46.28%) and G = 117 (45.70%)/101 (53.72%). We observed no significant differences between the three SNPs and development of calcium oxalate stones. Polymorphisms in rs6725958, rs10202709, and rs35343655 of the Fn gene had no obvious effect on the susceptibility to the development of calcium oxalate stones in the Uighur population, residing in the Xinjiang region of China.
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical, University, Urumqi, Xinjiang, China.
authors.forename: M
authors.initials: M
authors.lastname: Murat
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical, University, Urumqi, Xinjiang, China.
authors.forename: A
authors.initials: A
authors.lastname: Aekeper
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical, University, Urumqi, Xinjiang, China.
authors.forename: L Y
authors.initials: LY
authors.lastname: Yuan
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical, University, Urumqi, Xinjiang, China.
authors.forename: T
authors.initials: T
authors.lastname: Alim
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical, University, Urumqi, Xinjiang, China.
authors.forename: G J
authors.initials: GJ
authors.lastname: Du
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical, University, Urumqi, Xinjiang, China.
authors.forename: A
authors.initials: A
authors.lastname: Abdusamat
authors.affiliation: Department of Urology, The Second Affiliated Hospital of Xinjiang Medical, University, Urumqi, Xinjiang, China.
authors.forename: G W
authors.initials: GW
authors.lastname: Wu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Aniwer
mesh_terms: D000328:Adult; D000483:Alleles; D002129:Calcium Oxalate; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005353:Fibronectins / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D014545:Urinary Calculi / Q000737:chemistry* / Q000235:genetics*
chemical_list: D005353:Fibronectins; D002129:Calcium Oxalate