title: Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women.
abstract: Failure in antimicrobial activity contributes to high morbidity and mortality in the geriatric population. Little is known about the potential effect of resistance training (RT) on the functional properties of the innate immunity. This study aimed to investigate the influence of long-term RT on the endocytic and oxidative activities of neutrophils and monocytes in healthy older women. Our results indicate that the phagocytosis index (PhI) of neutrophils (but not of monocytes) in the RT-adapted group was significantly higher (P < 0.001; effect size, (d) = 0.90, 95% CI: [0.75-1.04]) compared to that in sedentary subjects. In contrast, the oxidative activity of either neutrophils or monocytes was not significantly influenced by RT. Also, total energy and carbohydrate intake as well as serum IL6 levels had a significant influence on the phagocytic activity of neutrophils (P = 0.04), being considered in the model. Multivariate regression identified the physical condition of the subject (β = 0.425; P = 0.01) as a significant predictor of PhI. In conclusion, circulating neutrophils of older women adapted to a long-term RT program expressed higher phagocytic activity.
authors.affiliation: Catholic University of Brasília, 71966-700 Brasília, DF, Brazil.
authors.forename: João
authors.initials: J
authors.lastname: Bartholomeu-Neto
authors.affiliation: Federal University of Juiz de Fora, 36036-330 Governador Valadares, MG, Brazil.
authors.forename: Ciro José
authors.initials: CJ
authors.lastname: Brito
authors.affiliation: University of Brasília, 70910-900 Brasília, DF, Brazil.
authors.forename: Otávio Toledo
authors.initials: OT
authors.lastname: Nóbrega
authors.affiliation: University of Brasília, 70910-900 Brasília, DF, Brazil.
authors.forename: Vinícius Carolino
authors.initials: VC
authors.lastname: Sousa
authors.affiliation: University of Brasília, 70910-900 Brasília, DF, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Oliveira Toledo
authors.affiliation: University of Brasília, 70910-900 Brasília, DF, Brazil.
authors.forename: Roberta
authors.initials: R
authors.lastname: Silva Paula
authors.affiliation: Catholic University of Brasília, 71966-700 Brasília, DF, Brazil.
authors.forename: David Junger Fonseca
authors.initials: DJ
authors.lastname: Alves
authors.affiliation: Paulista University, 70390-130 Brasília, DF, Brazil.
authors.forename: Aparecido Pimentel
authors.initials: AP
authors.lastname: Ferreira
authors.affiliation: Catholic University of Brasília, 71966-700 Brasília, DF, Brazil ; University of Brasília, 70910-900 Brasília, DF, Brazil.
authors.forename: Clayton
authors.initials: C
authors.lastname: Franco Moraes
authors.affiliation: Catholic University of Brasília, 71966-700 Brasília, DF, Brazil.
authors.forename: Cláudio
authors.initials: C
authors.lastname: Córdova
mesh_terms: D000222:Adaptation, Physiological; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007958:Leukocyte Count; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D010084:Oxidation-Reduction; D010587:Phagocytosis / Q000276:immunology*; D055070:Resistance Training; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D016207:Cytokines