title: Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men.
abstract: The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters including malondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, including body mass index (BMI), waist circumference (WC), sagittal abdominal diameter, fat percentages using dual-energy X-ray absorptiometry, visceral fat area (VFA), subcutaneous fat area, multiple biomarkers related to metabolic disease, and urinary MDA, in 73 asymptomatic middle-aged men who were not severely obese. We examined relationships between multiple measures of obesity, metabolic markers, and urinary MDA levels and evaluated associations between VFA and urinary MDA. In the visceral obesity group, γ-glutamyl transferase (GGT), uric acid, and urinary MDA levels were significantly higher than in the nonvisceral obesity group (P = 0.008, P = 0.002, and P = 0.018). Urinary MDA (r = 0.357, P = 0.002) and uric acid (r = 0.263, P = 0.027) levels were only significantly positively correlated with VFA among measures of obesity. Urinary MDA, serum GGT, and serum CRP were significantly positively associated with VFA (P = 0.001, P = 0.046, and P = 0.023, resp.), even after adjusting for BMI and WC.
authors.affiliation: Department of Laboratory Medicine and Molecular Genetics and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
authors.forename: Sun Min
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
authors.forename: Young Hye
authors.initials: YH
authors.lastname: Cho
authors.affiliation: Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
authors.forename: Sang Yeoup
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Jeong
authors.affiliation: Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
authors.forename: A Ra
authors.initials: AR
authors.lastname: Cho
authors.affiliation: Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
authors.forename: Jeong Suk
authors.initials: JS
authors.lastname: Jeon
authors.affiliation: Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Park
authors.affiliation: Department of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.
authors.forename: Yun Jin
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.
authors.forename: Jeong Gyu
authors.initials: JG
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.
authors.forename: Yu Hyeon
authors.initials: YH
authors.lastname: Yi
authors.affiliation: Department of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Tak
authors.affiliation: Department of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.
authors.forename: Hye Rim
authors.initials: HR
authors.lastname: Hwang
authors.affiliation: Department of Family Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.
authors.forename: Seung-Hun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Research And Statistical Support, Research Institute of Convergence for Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Republic of Korea.
authors.forename: Junehee
authors.initials: J
authors.lastname: Han
mesh_terms: D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000652:urine; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000652:urine*; D008875:Middle Aged; D009765:Obesity / Q000652:urine; D056128:Obesity, Abdominal / Q000652:urine*; D018384:Oxidative Stress; D012044:Regression Analysis; D012907:Smoking; D014527:Uric Acid / Q000097:blood / Q000378:metabolism; D055105:Waist Circumference; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D008315:Malondialdehyde; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase