title: Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?
abstract: Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon and abdominal pain. This systematic review discusses approaches, challenges and perspectives into the use of nontraditional antioxidant therapy on IBD, including natural and synthetic compounds in both human and animal models. One hundred and thirty four papers were identified, of which only four were evaluated in humans. Some of the challenges identified in this review can shed light on this fact: lack of standardization of OS biomarkers, absence of safety data and clinical trials for the chemicals and biological molecules, as well as the fact that most of the compounds were not repeatedly tested in several situations, including acute and chronic colitis. This review hopes to stimulate researchers to become more involved in this fruitful area, to warrant investigation of novel, alternative and efficacious antioxidant-based therapies.
authors.affiliation: Faculdade de Nutrição/Universidade Federal de Alagoas (FANUT/UFAL), Brazil; Pós Graduação em Ciências da Saúde (PPGCS)/ Universidade Federal de Alagoas, Brazil. Electronic address: fabianamoura_al@hotmail.com.
authors.forename: Fabiana Andréa
authors.initials: FA
authors.lastname: Moura
authors.affiliation: Pós Graduação em Ciências da Saúde (PPGCS)/ Universidade Federal de Alagoas, Brazil. Electronic address: kiviaqueiroz@hotmail.com.
authors.forename: Kívia Queiroz
authors.initials: KQ
authors.lastname: de Andrade
authors.affiliation: Faculdade de Nutrição/Universidade Federal de Alagoas (FANUT/UFAL), Brazil; Instituto de Química e Biotecnologia (IQB), Universidade Federal de Alagoas (UFAL), Brazil. Electronic address: jcfs_nut@yahoo.com.br.
authors.forename: Juliana Célia Farias
authors.initials: JCF
authors.lastname: Dos Santos
authors.affiliation: Instituto de Química e Biotecnologia (IQB), Universidade Federal de Alagoas (UFAL), Brazil. Electronic address: orlanforpa@hotmail.com.br.
authors.forename: Orlando Roberto Pimentel
authors.initials: ORP
authors.lastname: Araújo
authors.affiliation: Instituto de Química e Biotecnologia (IQB), Universidade Federal de Alagoas (UFAL), Brazil. Electronic address: mariliaofg@gmail.com.
authors.forename: Marília Oliveira Fonseca
authors.initials: MOF
authors.lastname: Goulart
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000378:metabolism; D018384:Oxidative Stress; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants
keywords: Antioxidant therapy; Biomarkers; Complementary and alternative medicine; Crohn's disease; Inflammatory bowel diseases; Nutraceuticals; Oxidative stress; Ulcerative colitis