title: Magnetic resonance imaging of mechanical deformations.
abstract: A method for magnetic resonance imaging of mechanical deformations is presented. The method utilizes an MRI compatible device for inducing elastic deformations of a sample and a modified spin-echo imaging sequence with two position-encoding gradients added to the sequence symmetrically to the RF refocusing pulse. At the end of the first position-encoding gradient pulse, a sample deformation was induced by the deformational device, which applied a force to a plastic rod embedded in a gelatin cylindrical sample. The sample had to withstand repeated elastic deformations. Sample displacements up to 400 μm were encoded in the image signal phase by the use of position-encoding gradients. Images of different displacement components were acquired first by the use of position-encoding gradients in different directions and then processed by the 2D phase unwrap algorithm. Finally, images of normal and shear strain distribution were calculated from the displacement images. The obtained displacement and strain images enabled clear visualization of deformations and their extent in the sample with the displacement detection threshold in the range 0.3-0.6 μm, depending on the image echo time. The results of displacements were verified also by a DANTE tagging method and by an optical method. The presented method enables studying of various types of deformations in different soft materials as well as dynamic response of deformations to different stress functions (static, oscillatory, pulsed…).
authors.affiliation: Jožef Stefan Institute, Jamova 39, Ljubljana 1000, Slovenia.
authors.forename: Gregor
authors.initials: G
authors.lastname: Koder
authors.affiliation: Jožef Stefan Institute, Jamova 39, Ljubljana 1000, Slovenia. Electronic address: igor.sersa@ijs.si.
authors.forename: Igor
authors.initials: I
authors.lastname: Serša
mesh_terms: D000465:Algorithms; D055119:Elastic Modulus / Q000502:physiology*; D054459:Elasticity Imaging Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D008846:Micromanipulation / Q000295:instrumentation*; D019047:Phantoms, Imaging; D010812:Physical Stimulation / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical
keywords: Deformations; Position encoding; Pulsed gradients; Strain imaging