title: Molecular detection of pancreatic neoplasia: Current status and future promise.
abstract: Pancreatic cancer is usually diagnosed at an advanced stage and curative resection is feasible in only a small minority of patients at the time of diagnosis. Diagnosis at an early stage is unequivocally associated with better long-term survival. Several candidate molecular markers for early detection are currently under investigation in different phases of discovery and validation. Recent advances in the technology for whole genome, methylome, ribonucleome, and proteome interrogation has enabled rapid advancements in the field of biomarker discovery. In this review we discuss the current status of molecular markers for detection of pancreatic cancer in blood, pancreatic cyst fluid, pancreatic juice and stool and briefly highlight some promising preliminary results of new approaches that have the potential of advancing this field in the near future.
authors.affiliation: Shounak Majumder, Suresh T Chari, David A Ahlquist, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: Shounak
authors.initials: S
authors.lastname: Majumder
authors.affiliation: Shounak Majumder, Suresh T Chari, David A Ahlquist, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: Suresh T
authors.initials: ST
authors.lastname: Chari
authors.affiliation: Shounak Majumder, Suresh T Chari, David A Ahlquist, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States.
authors.forename: David A
authors.initials: DA
authors.lastname: Ahlquist
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D004059:Diffusion of Innovation; D055088:Early Detection of Cancer; D005243:Feces / Q000737:chemistry; D005544:Forecasting; D020022:Genetic Predisposition to Disease; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000639:trends; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000737:chemistry / Q000473:pathology; D010189:Pancreatic Juice / Q000737:chemistry; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D010641:Phenotype; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor
keywords: Biomarkers; Early detection of cancer; Methylation; Pancreatic cancer; Pancreatic cyst fluid; Pancreatic juice; Sensitivity and specificity; Stool