title: Minimal Clinically Important Difference on Parkinson's Disease Sleep Scale 2nd Version.
abstract: Background and Aims. The aim of the present study was to determine the estimates of minimal clinically important difference for Parkinson's Disease Sleep Scale 2nd version (PDSS-2) total score and dimensions. Methods. The subject population consisted of 413 PD patients. At baseline, MDS-UPDRS, Hoehn-Yahr Scale, Mattis Dementia Rating Scale, and PDSS-2 were assessed. Nine months later the PDSS-2 was reevaluated with the Patient-Reported Global Impression Improvement Scale. Both anchor-based techniques (within patients' score change method and sensitivity- and specificity-based method by receiver operating characteristic analysis) and distribution-based approaches (effect size calculations) were utilized to determine the magnitude of minimal clinically important difference. Results. According to our results, any improvements larger than -3.44 points or worsening larger than 2.07 points can represent clinically important changes for the patients. These thresholds have the effect size of 0.21 and -0.21, respectively. Conclusions. Minimal clinically important differences are the smallest change of scores that are subjectively meaningful to patients. Studies using the PDSS-2 as outcome measure should utilize the threshold of -3.44 points for detecting improvement or the threshold of 2.07 points for observing worsening.
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Horváth
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Aschermann
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Ács
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Deli
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7623, Hungary ; MTA-PTE Clinical Neuroscience MR Research Group, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Janszky
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Sámuel
authors.initials: S
authors.lastname: Komoly
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Kázmér
authors.initials: K
authors.lastname: Karádi
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Márton
authors.initials: M
authors.lastname: Kovács
authors.affiliation: Doctoral School of Clinical Neuroscience, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Makkos
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Faludi
authors.affiliation: Department of Neurology, University of Pécs, Rét Utca 2, Pécs 7623, Hungary ; MTA-PTE Clinical Neuroscience MR Research Group, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Norbert
authors.initials: N
authors.lastname: Kovács