title: Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms.
abstract: To investigate the effect of calcium ions on the disintegration of enteric-coated dosage forms, disintegration testing was performed on enteric-coated aspirin tablets in the presence and absence of calcium in the test media. The results show that the presence of calcium ions retards the disintegration of enteric-coated dosage forms. This finding, which has not been reported in scientific literature, sheds light on the importance of conducting well-designed detailed investigations into the potential of calcium from dietary sources, calcium supplements, antacids, and/or phosphate binders affecting the absorption of drugs formulated into enteric-coated dosage forms. Moreover, it shows the necessity to investigate the potential of the occurrence of additional nutrient-excipient interactions.
authors.affiliation: Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Jozef
authors.initials: J
authors.lastname: Al-Gousous
authors.affiliation: Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address: langguth@uni-mainz.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Langguth
mesh_terms: D001241:Aspirin / Q000737:chemistry / Q000378:metabolism; D002122:Calcium Chloride / Q000737:chemistry* / Q000378:metabolism*; D004304:Dosage Forms; D065546:Drug Liberation; D012995:Solubility; D013608:Tablets, Enteric-Coated / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D004304:Dosage Forms; D013608:Tablets, Enteric-Coated; D002122:Calcium Chloride; D001241:Aspirin
keywords: bioavailability; calcium; disintegration; dissolution; enteric coating; excipient; interaction; nutrient