title: Acquired multiple acyl-CoA dehydrogenase deficiency and marked selenium deficiency causing severe rhabdomyolysis in a horse.
abstract: This report describes a case of severe rhabdomyolysis in a pregnant mare associated with histopathologic and biochemical features of both selenium deficiency and acquired multiple acyl-CoA dehydrogenase deficiency (MADD) due to seasonal pasture myopathy (SPM). This case highlights the importance of assessing plasma selenium levels in horses with clinical signs of pasture myopathy as this deficiency may be a contributing or exacerbating factor.
authors.affiliation: Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).
authors.forename: Diego E
authors.initials: DE
authors.lastname: Gomez
authors.affiliation: Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Valberg
authors.affiliation: Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).
authors.forename: K Gary
authors.initials: KG
authors.lastname: Magdesian
authors.affiliation: Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).
authors.forename: Paul E
authors.initials: PE
authors.lastname: Hanna
authors.affiliation: Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).
authors.forename: Jeanne
authors.initials: J
authors.lastname: Lofstedt
mesh_terms: D000818:Animals; D005260:Female; D006734:Horse Diseases / Q000209:etiology* / Q000473:pathology; D006736:Horses; D044342:Malnutrition / Q000150:complications / Q000662:veterinary*; D054069:Multiple Acyl Coenzyme A Dehydrogenase Deficiency / Q000097:blood / Q000662:veterinary*; D018482:Muscle, Skeletal / Q000201:enzymology; D009135:Muscular Diseases / Q000150:complications / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D011247:Pregnancy; D011248:Pregnancy Complications; D012206:Rhabdomyolysis / Q000209:etiology / Q000662:veterinary*; D012621:Seasons; D012643:Selenium / Q000172:deficiency*
chemical_list: D012643:Selenium