title: Plasma MASP-1 concentration and its relationship to recovery from coronary artery lesion in children with Kawasaki disease.
abstract: BACKGROUND
  This study investigated prognostic factors for early recovery of coronary artery lesion (CAL) in children with Kawasaki disease (KD).
  
  
  METHODS
  Patients hospitalized for KD were enrolled less than 2 wk from the onset of illness and divided into two groups: KD with CAL and KD without CAL. The CAL group was further divided into two subgroups according to the degree of CAL: mild (n = 31) and moderate/severe (n = 6) and further divided into two subgroups according to the age: younger than 1 y (n = 9) and older than 1 y (n = 28). Lectin pathway-related factors MASP-1, CD59, and C5b-9 were measured, along with C-reactive protein, white blood cell counts, erythrocyte sedimentation rate, and platelet count. Patients were followed up for 3 mo. Correlation between the measured factors and the length of time of recovery from CAL was analyzed.
  
  
  RESULTS
  Plasma concentrations of MASP-1 in the CAL group were significantly lower than those without CAL. MASP-1 and gender positively correlated with the recovery time of CAL. There was no difference in MASP-1 between mild and moderate/severe CAL. At 3-mo follow-up, there was a positive correlation between plasma MASP-1 concentration and recovery time of the patients with CAL older than 1 y.
  
  
  CONCLUSIONS
  Plasma MASP-1 concentration at the early stage of KD is predictive of length of time of recovery from CAL.
authors.affiliation: Department of Cardiovascular Diseases, Children's Hospital Affiliated to the Capital Institute of Pediatrics, Beijing, China.
authors.forename: Rui-Xia
authors.initials: RX
authors.lastname: Song
authors.affiliation: Department of Emergency, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, China.
authors.forename: Qing-Mei
authors.initials: QM
authors.lastname: Zou
authors.affiliation: Department of Cardiovascular Diseases, Children's Hospital Affiliated to the Capital Institute of Pediatrics, Beijing, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Li
authors.affiliation: Department of Emergency, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, China.
authors.forename: Nan-Ping
authors.initials: NP
authors.lastname: Xu
authors.affiliation: Central Laboratory of Infection and Immunity, Capital Institute of Pediatrics, Beijing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Clinical Center Laboratory, Capital Institute of Pediatrics, Beijing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Fu
authors.affiliation: Clinical Center Laboratory, Capital Institute of Pediatrics, Beijing, China.
authors.forename: Xiao-Dai
authors.initials: XD
authors.lastname: Cui
mesh_terms: D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D018957:CD59 Antigens / Q000097:blood; D016022:Case-Control Studies; D002675:Child, Preschool; D015938:Complement Membrane Attack Complex / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000201:enzymology / Q000209:etiology; D004452:Echocardiography; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D018836:Inflammation Mediators / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D050606:Mannose-Binding Protein-Associated Serine Proteases / Q000032:analysis*; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000201:enzymology; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; D018957:CD59 Antigens; D015938:Complement Membrane Attack Complex; D018836:Inflammation Mediators; C051590:CD59 protein, human; D002097:C-Reactive Protein; C084067:MASP1 protein, human; D050606:Mannose-Binding Protein-Associated Serine Proteases