title: Relation of apparent diffusion coefficient with Ki-67 proliferation index in meningiomas.
abstract: OBJECTIVE
  The purpose of this study was to investigate the relationship between Ki-67 proliferation indexes and apparent diffusion coefficient (ADC) values of low-grade and atypical/anaplastic (high-grade) meningiomas.
  
  
  METHODS
  Pre-operative diffusion-weighted imaging and histopathological evaluation of 44 patients with meningiomas were performed retrospectively. Regions of interest (ROIs) were manually drawn on the ADC images. In total six ROI measurements were taken in three consecutive slices, and the average of the mean ADC value was used. The relationship between the ADC and Ki-67 values was investigated, and the ADC values of the low-grade and high-grade meningiomas were compared.
  
  
  RESULTS
  31 (70%) patients had low-grade the meningiomas. 10 (23%) patients had atypical and 3 (7%) had anaplastic meningiomas. ADC values of the low-grade and high-grade meningiomas were 0.81 ± 0.12 × 10(-3) and 0.66 ± 0.08 × 10(-3) mm(2) s(-1), respectively. Ki-67 proliferation indexes were 2.19% ± 1.14% for low-grade and 11.20% ± 9.80% for high-grade meningiomas. A statistically significant negative correlation between Ki-67 proliferation index and ADC values of the low-grade and high-grade meningiomas was detected (r(2) = 0.326, p < 0.001). High-grade meningiomas had lower ADC values than that of low-grade meningiomas. There was statistically significant difference between the ADC values of the low-grade and high-grade meningiomas (p < 0.001).
  
  
  CONCLUSIONS
  Our data provide an inverse correlation between the ADC and Ki-67 proliferation index values of meningiomas. ADC values can be used for histopathological characterization of the meningiomas and pre-surgical planning.
  
  
  CONCLUSIONS
  The purpose of this study was to investigate the relationship between Ki-67 proliferation indexes and ADC values of low-grade and atypical/anaplastic (high-grade) meningiomas. In addition, we compared the ADC and Ki-67 proliferative index values of the low-grade and atypical/anaplastic (high-grade) meningiomas. We concluded that there was an inverse correlation between the ADC and Ki-67 proliferation index values in meningiomas, and we have found statistically significant difference between the ADC values of the low-grade and high-grade meningiomas. ADC values can be used for histopathological characterization of the meningiomas and pre-surgical planning.
authors.affiliation: 1 Department of Radiology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Ozdil
authors.initials: O
authors.lastname: Baskan
authors.affiliation: 2 Department of Neurosurgery, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Gokalp
authors.initials: G
authors.lastname: Silav
authors.affiliation: 2 Department of Neurosurgery, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Fatih Han
authors.initials: FH
authors.lastname: Bolukbasi
authors.affiliation: 3 Department of Medical Pathology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Canoz
authors.affiliation: 1 Department of Radiology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Geyik
authors.affiliation: 2 Department of Neurosurgery, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Elmaci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D049109:Cell Proliferation; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen