title: Oral Manifestations of Osteopetrosis.
abstract: Osteopetrosis is a hereditary disorder of bone characterized by sclerosis of bone and decreased marrow spaces. Due to depressed marrow function, this disorder can cause anemia, hepatosplenomegaly, recurrent infections and osteomyelitis of jaw. Excessive bone deposition in skull base leads to narrowing of foramina and cranial nerve compression. Bone marrow transplantation is the only curative treatment. Other treatments, like interferon gamma, corticosteroids, parathormone and erythropoietin are also used for management. Transfusion of blood, debridement of wound and antibiotics is used to manage complications. Due to its rarity, it is always difficult to diagnose osteopetrosis. Proper diagnosis and treatment decreases the long-term sequelae of the disease.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Nishtar Institute of Dentistry, Multan.
authors.forename: Ahsan
authors.initials: A
authors.lastname: Ullah
authors.affiliation: Department of Oral and Maxillofacial Surgery, Nishtar Institute of Dentistry, Multan.
authors.forename: Namal
authors.initials: N
authors.lastname: Pervez
authors.affiliation: Department of Oral and Maxillofacial Surgery, Nishtar Institute of Dentistry, Multan.
authors.forename: Shammas Raza
authors.initials: SR
authors.lastname: Khan
authors.affiliation: Department of Oral and Maxillofacial Surgery, Nishtar Institute of Dentistry, Multan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ishfaq
authors.affiliation: Department of Oral and Maxillofacial Surgery, Nishtar Institute of Dentistry, Multan.
authors.forename: Sehrish
authors.initials: S
authors.lastname: Liaqat
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001803:Blood Transfusion; D002675:Child, Preschool; D002710:Chlorhexidine / Q000627:therapeutic use; D003475:Curettage; D003646:Debridement; D006801:Humans; D000069349:Linezolid / Q000008:administration & dosage; D008795:Metronidazole / Q000627:therapeutic use; D010019:Osteomyelitis / Q000150:complications; D010020:Osteonecrosis / Q000175:diagnosis* / Q000601:surgery; D010022:Osteopetrosis / Q000175:diagnosis* / Q000628:therapy; D011862:Radiography, Panoramic; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008795:Metronidazole; D000069349:Linezolid; D002710:Chlorhexidine