title: Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells.
abstract: A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-γ plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-γ. In general, IFN-γ affected KP in skin cells more than in melanoma cells, supporting IFN-γ roles in skin physiology and that of stromal cells in modulating the tumor microenvironment.
authors.forename: Renan Orsati
authors.initials: RO
authors.lastname: Clara
authors.forename: Nadine
authors.initials: N
authors.lastname: Assmann
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Ramos Moreno
authors.forename: Janine Baptista
authors.initials: JB
authors.lastname: Coimbra
authors.forename: Nadine
authors.initials: N
authors.lastname: Nurenberger
authors.forename: Katja
authors.initials: K
authors.lastname: Dettmer-Wilde
authors.forename: Peter Josef
authors.initials: PJ
authors.lastname: Oefner
authors.forename: Ana
authors.initials: A
authors.lastname: Campa
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D007737:Kynurenine / Q000096:biosynthesis*; D008544:Melanocytes / Q000378:metabolism*; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology*
chemical_list: D007737:Kynurenine; D007371:Interferon-gamma