title: Factors associated with outcome and gradual improvement in survival over time in 1065 equine neonates admitted to an intensive care unit.
abstract: BACKGROUND
  There is a paucity of information regarding the association between common disorders and outcome over time in a large population of ill equine neonates.
  
  
  OBJECTIVE
  To describe the relative frequency of neonatal disorders in a large population of foals admitted to a neonatal intensive care unit, to determine the disorders and factors associated with nonsurvival and determine if the outcome of ill neonatal foals has improved over time.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Cases were selected from equine neonatal (≤14 days of age) admissions between 1982 and 2008. Multivariable logistic regression was used to identify the disorders, clinical parameters and laboratory variables associated with nonsurvival or natural death and assess survival over time after accounting for potential confounding variables.
  
  
  RESULTS
  A total of 1065 foals were included in the study. Overall, 775 of 1065 (72.8%) foals survived to be discharged from the hospital and 290 (27.2%) foals were nonsurvivors. Age at admission, sepsis score, proportion of foals with positive blood cultures and proportion of survivors were significantly different (P<0.001) between primary disease categories. Variables retained in the multivariable model for nonsurvival included positive blood culture, neutrophils <2.28 × 109/l, temperature ≤37.6°C, bicarbonate, PCO2, presence of infectious orthopaedic disorders and sepsis score. The adjusted odds of survival for foals admitted in the 2000s were approximately 3.4 (95% CI = 1.9-6.0, P<0.001) times higher than that of foals admitted in the 1980s.
  
  
  CONCLUSIONS
  Primary disorders, sepsis, temperature, acid base status and neutropenia are the main factors that affect outcome in this population of equine neonates. The survival of foals admitted to a neonatal intensive care unit has increased dramatically over a 26 year period.
authors.affiliation: Veterinary Medical Center, University of Georgia, Athens, USA.
authors.forename: S
authors.initials: S
authors.lastname: Giguère
authors.affiliation: Hofmann Neonatal Intensive Care Unit, College of Veterinary Medicine, University of Florida, Gainesville, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Weber
authors.affiliation: Hofmann Neonatal Intensive Care Unit, College of Veterinary Medicine, University of Florida, Gainesville, USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Sanchez
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D016638:Critical Illness; D005260:Female; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D006762:Hospitals, Animal; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: foal; horse; neonatology; outcome; sepsis