title: The anti-nociceptive potential of tilmicosin against chemical-induced but not thermal-induced pain in mice.
abstract: The aim of the present study was to assess the analgesic activity of the macrolide antibiotic tilmicosin at dose levels of 20 and 40 mg/kg of body weight, subcutaneously, against chemical- and thermal-induced acute pains, using acetic acid-induced writhing, formalin-induced pain, hot-plate, and tail-flick models in mice. Tilmicosin showed a dose-dependent significant decrease in the number of writhes in the acetic acid-induced writhing test and significant decrease in hind paw-licking time in the late phase of the formalin test. However, it did not cause any significant changes in the reaction times to heat stimuli in the hot-plate and tail-flick models. In chemically-induced pains, both dose levels of tilmicosin showed significant effects compared to those of the corresponding standard peripheral analgesic, acetylsalicylic acid (200 mg/kg of body weight, subcutaneously) being 26.37±2.88 and 43.64±3.85% vs. 73.35±1.44% in acetic acid test; and 19.23±3.85 and 44.90±1.80% vs. 73.63±2.39% in the late phase of formalin test, respectively. These results may indicate that tilmicosin possesses a significant peripheral but not central analgesic potential that may be beneficial in symptomatic relief of pain when it is used in therapy, in addition to its well-established antibacterial effect.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: El-Mahmoudy
authors.affiliation: Department of Medical Laboratories Technology, Faculty of Applied Medical Sciences, Taibah University, 344 Medinah, Kingdom of Saudi Arabia Department of Biotechnology, Animal Health Research Institute, Dokki, Egypt, 11843 e.m.gheith@hotmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Gheith
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice; D015645:Tylosin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000700:Analgesics; C052319:tilmicosin; D015645:Tylosin
keywords: analgesic; anti-nociceptive; tilmicosin