title: Supramolecular Complexation of Carbohydrates for the Bioavailability Enhancement of Poorly Soluble Drugs.
abstract: In this review, a comprehensive overview of advances in the supramolecular complexes of carbohydrates and poorly soluble drugs is presented. Through the complexation process, poorly soluble drugs could be efficiently delivered to their desired destinations. Carbohydrates, the most abundant biomolecules, have diverse physicochemical properties owing to their inherent three-dimensional structures, hydrogen bonding, and molecular recognition abilities. In this regard, oligosaccharides and their derivatives have been utilized for the bioavailability enhancement of hydrophobic drugs via increasing the solubility or stability. By extension, polysaccharides and their derivatives can form self-assembled architectures with poorly soluble drugs and have shown increased bioavailability in terms of the sustained or controlled drug release. These supramolecular systems using carbohydrate will be developed consistently in the field of pharmaceutical and medical application.
authors.affiliation: Center for Biotechnology Research in UBITA (CBRU), Institute for Ubiquitous Information Technology and Applications (UBITA), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea. echo@konkuk.ac.kr.
authors.forename: Eunae
authors.initials: E
authors.lastname: Cho
authors.affiliation: Center for Biotechnology Research in UBITA (CBRU), Institute for Ubiquitous Information Technology and Applications (UBITA), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea. shjung@konkuk.ac.kr.|Microbial Carbohydrate Resource Bank (MBRC), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea. shjung@konkuk.ac.kr.|Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea. shjung@konkuk.ac.kr.
authors.forename: Seunho
authors.initials: S
authors.lastname: Jung
mesh_terms: D001682:Biological Availability; D002241:Carbohydrates / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010599:Pharmacokinetics; D012995:Solubility
chemical_list: D002241:Carbohydrates; D005079:Excipients; D004364:Pharmaceutical Preparations
keywords: bioavailability enhancement; carbohydrates; poorly soluble drugs; supramolecular complexation