title: Development of bilateral coronary artery aneurysms in a child with Noonan syndrome.
abstract: Noonan syndrome is a constellation of congenital malformations including heart defects, facial anomalies and short stature. The cardiovascular defects are variable and extensive, with the most common being pulmonary stenosis and hypertrophic cardiomyopathy. Coronary artery anomalies have only been reported in a few cases. We report a child with Noonan syndrome status post pulmonary stenosis and atrial septal defect repair, who developed bilateral coronary artery aneurysms. The aneurysms were diagnosed with both cardiac magnetic resonance imaging and coronary computed tomography angiography. There had been no evidence of them on a cardiac MR exam 5 years previously.
authors.affiliation: Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Mauro
authors.affiliation: Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: Lucia
authors.initials: L
authors.lastname: Flors
authors.affiliation: Department of Pediatrics, Division of Pediatric Cardiology, University of Virginia Health System, Lee St., Box 800170, Charlottesville, VA, 22908, USA.|Pediatric Cardiology Center of Oregon, Portland, OR, USA.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Hoyer
authors.affiliation: Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Norton
authors.affiliation: Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, USA. kdh2n@virginia.edu.
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Hagspiel
mesh_terms: D002648:Child; D000072226:Computed Tomography Angiography / Q000379:methods*; D003323:Coronary Aneurysm / Q000000981:diagnostic imaging*; D017023:Coronary Angiography / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D009634:Noonan Syndrome / Q000000981:diagnostic imaging*
keywords: Child; Computed tomography; Coronary aneurysm; Coronary artery; Magnetic resonance imaging; Noonan syndrome