title: Development of a Sendai virus vector-based AIDS vaccine inducing T cell responses.
abstract: Virus-specific CD8(+) T-cell responses play a major role in the control of HIV replication, and induction of HIV-specific T-cell responses is an important strategy for AIDS vaccine development. Optimization of the delivery system and immunogen would be the key for the development of an effective T cell-based AIDS vaccine. Heterologous prime-boost vaccine regimens using multiple viral vectors are a promising protocol for efficient induction of HIV-specific T-cell responses, and the development of a variety of potent viral vectors have been attempted. This review describes the current progress of the development of T cell-based AIDS vaccines using viral vectors, focusing on Sendai virus vectors, whose phase I clinical trials have been performed.
authors.affiliation: a AIDS Research Center , National Institute of Infectious Diseases , Tokyo , Japan.
authors.forename: Sayuri
authors.initials: S
authors.lastname: Seki
authors.affiliation: a AIDS Research Center , National Institute of Infectious Diseases , Tokyo , Japan.|b The Institute of Medical Science , The University of Tokyo , Tokyo , Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matano
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004337:Drug Carriers; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D005822:Genetic Vectors; D006801:Humans; D029082:Sendai virus / Q000235:genetics*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification
chemical_list: D016915:AIDS Vaccines; D004337:Drug Carriers; D014614:Vaccines, Synthetic
keywords: AIDS vaccine; CTL; HIV; SIV; Sendai virus