title: Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai.
abstract: BACKGROUND
  Type 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers. The aim of this study was to investigate the risk of common cancers in Chinese patients with T2DM.
  
  
  METHODS
  A population-based retrospective cohort study including 36,379 T2DM patients was conducted in Minhang District of Shanghai, China, during 2004 to 2010. All T2DM patients were enrolled from the standardized management system based on local electronic information system. Newly-diagnosed cancer cases were identified by record-linkage with the Shanghai Cancer Registry. Standardized incidence ratios (SIR) and 95% confidence interval (CI) were used to estimate the risk of cancers among T2DM patients.
  
  
  RESULTS
  Overall crude incidence rate (CIR) of cancers was 955.21 per 105 person-years in men and 829.57 per 105 person-years in women. Increased risk of cancer was found in both gender, with an SIR being 1.28 (95% CI = 1.17-1.38) in men and 1.44 (95% CI =1.32-1.55) in women. Increased risk of colon (SIR = 1.97; 95% CI = 1.49 to 2.46), rectum (1.72; 1.23 to 2.21), prostate (2.87; 2.19 to 3.56), and bladder cancers (1.98, 1.28 to 2.68) were observed in men and elevated risk of colon (1.67; 1.25 to 2.08), breast (1.66; 1.38 to 1.95), and corpus uteri cancers (2.87; 2.03 to 3.71) were observed in women.
  
  
  CONCLUSIONS
  Our results indicate that Chinese patients with T2DM may have an increased risk of some cancers, and the increase may vary by sub-sites of cancers.
authors.affiliation: School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China. iamxuhuilin@163.com.|Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. iamxuhuilin@163.com.
authors.forename: Hui-Lin
authors.initials: HL
authors.lastname: Xu
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. mhcdcfh@126.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Fang
authors.affiliation: School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China. wanghong.xu@fudan.edu.cn.
authors.forename: Wang-Hong
authors.initials: WH
authors.lastname: Xu
authors.affiliation: School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China. gyqin@fudan.edu.cn.
authors.forename: Guo-You
authors.initials: GY
authors.lastname: Qin
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. yanyujie@yahoo.com.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Yan
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. 09211020010@fudan.edu.cn.
authors.forename: Bao-Dong
authors.initials: BD
authors.lastname: Yao
authors.affiliation: School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China. nqzhao@fudan.edu.cn.
authors.forename: Nai-Qing
authors.initials: NQ
authors.lastname: Zhao
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. mhtnb@126.com.
authors.forename: Yi-Nan
authors.initials: YN
authors.lastname: Liu
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. mhqwsjyfk@126.com.
authors.forename: Fen
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. liweiwei0121037@163.com.
authors.forename: Wei-Xi
authors.initials: WX
authors.lastname: Li
authors.affiliation: School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China. nawang021@gmail.com.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. mhqfasc@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. mhmb220@163.com.
authors.forename: Jin-Ling
authors.initials: JL
authors.lastname: Zhang
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. mhmb219@163.com.
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Zhao
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. mhcdcmfk@126.com.
authors.forename: Lun-Qiang
authors.initials: LQ
authors.lastname: Li
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention, 965 Zhong Yi Road, Shanghai, 201101, People's Republic of China. zhaoyanping63@yeah.net.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D011159:Population Surveillance; D012306:Risk; D055815:Young Adult