title: Extracellular Vesicles as Natural Nanosized Delivery Systems for Small-Molecule Drugs and Genetic Material: Steps towards the Future Nanomedicines.
abstract: A new platform for drug, gene and peptide-protein delivery is emerging, under the common name of "extracellular vesicles". Extracellular vesicles (EVs) are 30-1000 nm-sized cell-derived, liposome-like vesicles. Current research on EVs as nano-delivery systems for small-molecule drugs and genetic material, reveal that these tiny, biologically-derived vesicles carry a great potential to boost the efficacy of many therapeutic protocols. Several features of EVs; from efficacy to safety, from passive to active targeting ability, the opportunity to be biologically or chemically labelled, and most importantly, their eobiotic origin make them promising candidate for development of the next generation personalized nanomedicines. The aim of this article is to provide a view on the current research in which EVs are used as drug/genetic material delivery systems. Their application areas, drug loading and targeting strategies, and biodistribution properties are discussed.
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, Izmir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kotmakçı
authors.forename: Vildan
authors.initials: V
authors.lastname: Bozok Çetintaş
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000235:genetics / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D055354:Exosomes / Q000235:genetics / Q000378:metabolism; D000067128:Extracellular Vesicles / Q000235:genetics / Q000378:metabolism*; D018014:Gene Transfer Techniques / Q000639:trends*; D006801:Humans; D050997:Nanomedicine / Q000379:methods / Q000639:trends*; D053758:Nanoparticles / Q000008:administration & dosage / Q000378:metabolism*; D014018:Tissue Distribution / Q000187:drug effects / Q000502:physiology