title: Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions.
abstract: BACKGROUND
  2C-B (Nexus) is one of the most widespread novel psychoactive substances. There is limited information about its pharmacological properties, and few studies in humans concern its acute and chronic effects. 2C-B has been classified as a stimulant, hallucinogen, entactogen, and/or empathogen.
  
  
  OBJECTIVE
  To evaluate the emotional, subjective, and cardiovascular effects of 2C-B.
  
  
  METHODS
  Twenty healthy recreational 2C-B users (12 women) self-administered a 20 mg dose of 2C-B. Evaluations included emotional (IAPS, FERT, and speech), subjective (visual analog scales, ARCI, VESSPA, HRS, and POMS questionnaires), and cardiovascular effects (blood pressure and heart rate). Results. Positive subjective effects predominated with a reduction of anger under the influence of 2C-B. It did, however, increase reactivity to negative emotional stimuli and decrease the ability to recognize expressions of happiness. Augmented emotionality in speech could be appreciated by others. 2C-B induced euphoria and well-being, changes in perceptions, and slight hallucinogenic states. Mild sympathetic actions were observed.
  
  
  CONCLUSIONS
  The specific profile that 2C-B exerts on emotions suggests its classification as an entactogen with psychedelic properties.
authors.affiliation: Department of Pharmacology and Department of Psychiatry, Universitat Autònoma de Barcelona, Doctor Aiguader 80, 08003 Barcelona, Spain ; Hospital del Mar Medical Research Institute (IMIM), Doctor Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Débora
authors.initials: D
authors.lastname: González
authors.affiliation: Department of Pharmacology and Department of Psychiatry, Universitat Autònoma de Barcelona, Doctor Aiguader 80, 08003 Barcelona, Spain ; Hospital del Mar Medical Research Institute (IMIM), Doctor Aiguader 88, 08003 Barcelona, Spain ; Institute of Neuropsychiatry and Addictions (INAD), Parc de Salut Mar, Paseo Marítimo 25, 08003 Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Torrens
authors.affiliation: Department of Pharmacology and Department of Psychiatry, Universitat Autònoma de Barcelona, Doctor Aiguader 80, 08003 Barcelona, Spain ; Hospital del Mar Medical Research Institute (IMIM), Doctor Aiguader 88, 08003 Barcelona, Spain ; Hospital Universitari Germans Trias i Pujol-HUGTP-IGTP, Carretera de Canyet, s/n, 08916 Badalona, Spain.
authors.forename: Magí
authors.initials: M
authors.lastname: Farré
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D004118:Dimethoxyphenylethylamine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004644:Emotions / Q000187:drug effects*; D005260:Female; D064368:Healthy Volunteers; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000008:administration & dosage* / Q000009:adverse effects; D011795:Surveys and Questionnaires
chemical_list: D004118:Dimethoxyphenylethylamine; D011619:Psychotropic Drugs; C079321:2-(4-bromo-2,5-dimethoxyphenyl)ethylamine