title: A PROSTHETIC GROUP FOR THE RAPID INTRODUCTION OF FLUORINE INTO PEPTIDES AND FUNCTIONALIZED DRUGS.
abstract: Fluoride ion as the tetrabutylammonium salt displaces bromide in para-substituted benzyl bromides in acetonitrile or dimethylformamide. The p-bromomethyl benzoyl (BMB) group has been coupled to amino groups, including peptide amino groups, via its N-hydroxysuccinimide ester. In a subsequent step, the facile displacement of bromide by fluoride occurred under conditions compatible for use with (18)F radiotracers.
authors.affiliation: Laboratory of Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892 (U.S.A.).
authors.forename: K A
authors.initials: KA
authors.lastname: Jacobson
authors.affiliation: Laboratory of Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892 (U.S.A.).
authors.forename: D C
authors.initials: DC
authors.lastname: Furlano
authors.affiliation: Laboratory of Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892 (U.S.A.).
authors.forename: K L
authors.initials: KL
authors.lastname: Kirk