title: Archaic RDA Methodology for Vitamin C.
abstract: Frei et al's 2012 review entitled "Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans" is both flawed and misleading. RCTs are ill suited to determining the RDA, it is debatable that there is sufficient scientific evidence to determine the optimum intake of vitamin C in humans, observations regarding high-doses of ascorbate have been ignored, and there are inaccuracies of fact with respect to the saturation of blood plasma following low dose intake. Until the limitations of current knowledge are recognised it is unwise to set limits on the dose.
authors.affiliation: a Newlyn Research Group , Newlyn , Cornwall , England.
authors.forename: Steve
authors.initials: S
authors.lastname: Hickey
authors.affiliation: b Ortho Institute , Gendringen , Netherlands.
authors.forename: Gert
authors.initials: G
authors.lastname: Schuitemaker
authors.affiliation: c Japanese College of IV Therapy , Tokyo , Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Yanagisawa
authors.affiliation: d Staffordshire University , Stafford , England.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Noriega
authors.affiliation: e University of Puerto Rico, Medical Sciences Campus , San Juan , PR , USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: González
authors.affiliation: f University of Puerto Rico , San Juan , PR , USA.
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Miranda-Massari
authors.affiliation: d Staffordshire University , Stafford , England.
authors.forename: Caroline
authors.initials: C
authors.lastname: Chibelushi
authors.affiliation: g British Society for Ecological Medicine , London , England.
authors.forename: Damien
authors.initials: D
authors.lastname: Downing