title: Amyloidosis of the Breast: Three Different and Unusual Presentations of a Rare Entity.
abstract: BACKGROUND
  Amyloidosis involving the breast is a rare finding and it may present as a solitary mass called 'amyloid tumor'. According to the largest case series, the amyloid deposits are usually of the AL type (commonly x03BA; light chain).
  
  
  METHODS
  We report 3 cases diagnosed at our institution in the period from 2000 to 2015. Radiological, histological and immunohistochemical studies were performed.
  
  
  CONCLUSIONS
  Together with a case presenting in a patient with multiple myeloma, we describe 2 unique presentations including 1 associated with CREST syndrome in a patient with a previous history of breast carcinoma and another, also associated with cancer, with transthyretin deposits in a woman with a TTR gene mutation and a family history of familial amyloidotic polyneuropathy. These cases are an example of the vast heterogeneity of this disorder regarding its clinical presentation, the type of amyloid deposits and other diseases associated with breast amyloidosis.
authors.affiliation: Department of Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Herrero
authors.forename: Dolores
authors.initials: D
authors.lastname: Naranjo-Hans
authors.forename: Manel
authors.initials: M
authors.lastname: Solé
authors.forename: Gorane
authors.initials: G
authors.lastname: Santamaría
authors.forename: Xavier
authors.initials: X
authors.lastname: Bargalló
authors.forename: Martín
authors.initials: M
authors.lastname: Velasco
authors.forename: Pedro Luis
authors.initials: PL
authors.lastname: Fernández
mesh_terms: D000368:Aged; D017772:Amyloid Neuropathies / Q000150:complications / Q000151:congenital; D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D001940:Breast / Q000473:pathology* / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000150:complications; D017675:CREST Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D009154:Mutation; D011228:Prealbumin / Q000235:genetics; D011859:Radiography; D035583:Rare Diseases
chemical_list: D011228:Prealbumin