title: Depression, Anxiety, and Regret Before and After Testing to Estimate Uveal Melanoma Prognosis.
abstract: OBJECTIVE
  To our knowledge, longitudinal assessment of depression, anxiety, and decision regret (a sense of disappointment or dissatisfaction in the decision) in patients undergoing prognostication for uveal melanoma does not exist.
  
  
  OBJECTIVE
  To report on depression, anxiety, and decision regret before and after testing to estimate uveal melanoma prognosis.
  
  
  METHODS
  Prospective interventional case series conducted at an institutional referral practice of 96 patients with clinical diagnosis of uveal melanoma who underwent prognostication at the time of primary therapy.
  
  
  METHODS
  Depression, anxiety, and decision regret prior to prognostication (baseline) and at 3 and 12 months afterwards. The Hospital Anxiety and Depression Scale (HADS) and Decision Regret Scale were self-administered by the patients prior to prognostication (baseline) and at 3 and 12 months afterwards. Data were summarized using means and standard deviations for continuous measures, frequencies, and percentages for categorical factors. A mixed model was used to assess the trajectory of HADS anxiety and the associations between HADS anxiety and baseline HADS depression, baseline decision regret, prognostication test result, and adjuvant therapy, respectively, while adjusting for age and sex.
  
  
  RESULTS
  Ninety-six patients (median age 60.7 years) completed baseline questionnaires. The mean (SD) HADS anxiety score at baseline (7.4 [4.0]) was higher than at 3 months (5.4 [3.7]; P < .001) or 12 months (4.7 [3.4]; P < .001), and decreased with older age (coefficient estimate [SD], -0.06 [0.02]; P < .001). The decision regret score was associated with baseline HADS depression score (coefficient estimate [SE], -1.17 [0.43]; P < .007), and HADS depression score increased with baseline HADS anxiety score (coefficient estimate [SE], 0.39 [0.06]; P < .001).
  
  
  CONCLUSIONS
  Our study raises questions about decision regret in patients who agree to have a prognostic test that may not help guide treatment. Although decision regret appears to lessen or dissipate with time, study on larger numbers of patients is necessary to elucidate factors that may be addressed to mitigate decision regret.
authors.affiliation: Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Isabel
authors.initials: I
authors.lastname: Schuermeyer
authors.affiliation: Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Anca
authors.initials: A
authors.lastname: Maican
authors.affiliation: Center for Ethics, Humanities, and Spiritual Care, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Richard
authors.initials: R
authors.lastname: Sharp
authors.affiliation: Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
authors.forename: James
authors.initials: J
authors.lastname: Bena
authors.affiliation: Solid Tumor Oncology, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Pierre L
authors.initials: PL
authors.lastname: Triozzi
authors.affiliation: Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Arun D
authors.initials: AD
authors.lastname: Singh
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000523:psychology*; D065187:Controlled Before-After Studies; D003657:Decision Making; D003863:Depression / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000523:psychology*; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011584:Psychology; D011788:Quality of Life / Q000523:psychology; D013315:Stress, Psychological / Q000523:psychology*; D011795:Surveys and Questionnaires; D014604:Uveal Neoplasms / Q000175:diagnosis* / Q000523:psychology*; D000098943:Uveal Melanoma