title: Maternal high-fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring.
abstract: OBJECTIVE
  To utilize a nonhuman primate model to examine the impact of maternal high-fat diet (HFD) consumption and pre-pregnancy obesity on offspring intake of palatable food and to examine whether maternal HFD consumption impaired development of the dopamine system, critical for the regulation of hedonic feeding.
  
  
  METHODS
  The impact of exposure to maternal HFD and obesity on offspring consumption of diets of varying composition was assessed after weaning. The influence of maternal HFD consumption on the development of the prefrontal cortex-dopaminergic system at 13 months of age was also examined.
  
  
  RESULTS
  During a preference test, offspring exposed to maternal HFD consumption and obesity displayed increased intake of food high in fat and sugar content relative to offspring from lean control mothers. Maternal HFD consumption suppressed offspring dopamine signaling (as assessed by immunohistochemistry) relative to control offspring. Specifically, there was decreased abundance of dopamine fibers and of dopamine receptor 1 and 2 proteins.
  
  
  CONCLUSIONS
  This study reveals that offspring exposed to both maternal HFD consumption and maternal obesity during early development are at increased risk for obesity due to overconsumption of palatable energy-dense food, a behavior that may be related to reduced central dopamine signaling.
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Heidi M
authors.initials: HM
authors.lastname: Rivera
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Kievit
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Kirigiti
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Leigh Ann
authors.initials: LA
authors.lastname: Bauman
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Karalee
authors.initials: K
authors.lastname: Baquero
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Blundell
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Tyler A
authors.initials: TA
authors.lastname: Dean
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Jeanette C
authors.initials: JC
authors.lastname: Valleau
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Diana L
authors.initials: DL
authors.lastname: Takahashi
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: Frazee
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.|Department of Biology, University of Portland, Portland, Oregon, USA.
authors.forename: Luke
authors.initials: L
authors.lastname: Douville
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Jordan
authors.initials: J
authors.lastname: Majer
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: M Susan
authors.initials: MS
authors.lastname: Smith
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Grove
authors.affiliation: Division of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oregon, USA.|Department of Biology, University of Portland, Portland, Oregon, USA.|Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA.
authors.forename: Elinor L
authors.initials: EL
authors.lastname: Sullivan
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D004298:Dopamine / Q000378:metabolism*; D004435:Eating / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D023421:Models, Animal; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism* / Q000503:physiopathology; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism / Q000503:physiopathology; D011323:Primates; D015398:Signal Transduction; D013649:Taste / Q000502:physiology
chemical_list: D004298:Dopamine