title: Tribbles role in reproduction.
abstract: Tribbles (TRIB) proteins, a family of evolutionary conserved psuedokinase proteins, modulate various signalling pathways within the cell. The regulatory roles of TRIB make them an important part of a number of biological processes ranging from cell proliferation to metabolism, immunity, inflammation and carcinogenesis. Innate immune system plays a pivotal role during the regulation of reproductive processes that allows successful creation of an offspring. Its involvement initiates from fertilization of the oocyte by spermatozoon and lasts throughout early embryonic development, pregnancy and labour. Therefore, there is a close cooperation between the reproductive system and the innate immune system. Evidence from our lab has demonstrated that improper activation of the innate immune system can reduce embryo implantation, thus leading to infertility. Therefore, control mechanisms regulating the innate immune system function can be critical for successful reproductive events.
authors.affiliation: Academic Unit of Reproductive and Developmental Medicine, Department of Human Metabolism, The Medical School, University of Sheffield, Level 4, The Jessop Wing, Tree Root Walk, Sheffield S10 2SF, U.K.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Basatvat
authors.affiliation: St James' Biomedical Services, University of Leeds, Clinical Sciences Building, St James' Hospital, Beckett Street, Leeds LS9 7TF, U.K.
authors.forename: Deborah Angela Louise
authors.initials: DA
authors.lastname: Carter
authors.affiliation: Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, U.K.
authors.forename: Endre
authors.initials: E
authors.lastname: Kiss-Toth
authors.affiliation: Academic Unit of Reproductive and Developmental Medicine, Department of Human Metabolism, The Medical School, University of Sheffield, Level 4, The Jessop Wing, Tree Root Walk, Sheffield S10 2SF, U.K. a.fazeli@sheffield.ac.uk.
authors.forename: Alireza
authors.initials: A
authors.lastname: Fazeli
mesh_terms: D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008954:Models, Biological; D009865:Oocytes / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*; D012098:Reproduction / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; D012097:Repressor Proteins; C493170:TRIB1 protein, human; C474831:TRIB3 protein, human; D051193:Toll-Like Receptors; D017346:Protein Serine-Threonine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C489044:TRIB2 protein, human
keywords: embryo implantation; fertility; innate immunity; toll-like receptor signalling pathways; tribbles