title: Magnetic-Responsive Release Controlled by Hot Spot Effect.
abstract: Magnetically triggered drug delivery nanodevices have attracted great attention in nanomedicine, as they can feature as smart carriers releasing their payload at clinician's will. The key principle of these devices is based on the properties of magnetic cores to generate thermal energy in the presence of an alternating magnetic field. Then, the temperature increase triggers the drug release. Despite this potential, the rapid heat dissipation in living tissues is a serious hindrance for their clinical application. It is hypothesized that magnetic cores could act as hot spots, this is, produce enough heat to trigger the release without the necessity to increase the global temperature. Herein, a nanocarrier has been designed to respond when the temperature reaches 43 °C. This material has been able to release its payload under an alternating magnetic field without the need of increasing the global temperature of the environment, proving the efficacy of the hot spot mechanism in magnetic-responsive drug delivery devices.
authors.affiliation: Departamento de Química Inorgánica y Bioinorgánica, UCM, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) , 28029 Madrid, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Guisasola
authors.affiliation: Departamento de Química Inorgánica y Bioinorgánica, UCM, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) , 28029 Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Baeza
authors.affiliation: Departamento de Química Inorgánica y Bioinorgánica, UCM, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) , 28029 Madrid, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Talelli
authors.affiliation: Departamento de Química Inorgánica y Bioinorgánica, UCM, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) , 28029 Madrid, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Arcos
authors.affiliation: Instituto de Nanociencia de Aragon, Universidad de Zaragoza , C/Mariano Esquillor s/n, 50018 Zaragoza, Spain.|Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello", Via Campi Flegrei 34, 80078 Pozzuoli (Naples), Italy.
authors.forename: María
authors.initials: M
authors.lastname: Moros
authors.affiliation: Instituto de Ciencia de Materiales de Aragón, CSIC-Universidad de Zaragoza , C/Pedro Cerbuna 12, 50018 Zaragoza, Spain.
authors.forename: Jesús M
authors.initials: JM
authors.lastname: de la Fuente
authors.affiliation: Departamento de Química Inorgánica y Bioinorgánica, UCM, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) , 28029 Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Vallet-Regí
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000295:instrumentation*; D019793:Fluorescein / Q000737:chemistry; D060328:Magnetic Phenomena; D053758:Nanoparticles / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D003692:Delayed-Action Preparations; C052970:poly-N-isopropylacrylamide; D012822:Silicon Dioxide; D019793:Fluorescein; C066443:N-methylolacrylamide