title: Selenoprotein P is not elevated in gestational diabetes mellitus.
abstract: Selenoprotein P concentrations have been found to be associated with insulin resistance and elevated in patients with type 2 diabetes mellitus (DM). The aim of the present study was to investigate circulating selenoprotein P level and its possible relationship with metabolic parameters in gestational diabetes mellitus (GDM). Plasma selenoprotein P concentrations were measured in 30 pregnant women with GDM, 35 pregnant women without GDM and 22 healthy nonpregnant women. No difference in selenoprotein P levels was observed among the groups [6.2 (4.5-8.2), 7.9 (4.5-10.7) and 6.7 (5.3-9.1) ng/ml, respectively, p = 0.69]. In pregnant women with and without GDM, selenoprotein P did not correlate with age, gestational age, prepregnancy body mass index (BMI), HbA1c, glucose concentrations at oral glucose tolerance test (OGTT), area under curve (AUC) glucose, total cholesterol, LDL cholesterol and triglycerides levels (p > 0.05). But, there were statistically significant correlations between selenoprotein P and current BMI (r = -0.28, p = 0.04) and HDL cholesterol levels (r = 0.43, p = 0.01). We found that selenoprotein P concentrations are not elevated in women with GDM but associated with BMI and HDL cholesterol.
authors.affiliation: a Department of Endocrinology and Metabolism .
authors.forename: Alev E
authors.initials: AE
authors.lastname: Altinova
authors.affiliation: a Department of Endocrinology and Metabolism .
authors.forename: Ozlem T
authors.initials: OT
authors.lastname: Iyidir
authors.affiliation: a Department of Endocrinology and Metabolism .
authors.forename: Cigdem
authors.initials: C
authors.lastname: Ozkan
authors.affiliation: b Department of Internal Medicine .
authors.forename: Damla
authors.initials: D
authors.lastname: Ors
authors.affiliation: c Department of Obstetrics and Gynecology , and.
authors.forename: Merve
authors.initials: M
authors.lastname: Ozturk
authors.affiliation: d Department of Biochemistry , Faculty of Medicine, Gazi University , Ankara , Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gulbahar
authors.affiliation: c Department of Obstetrics and Gynecology , and.
authors.forename: Nuray
authors.initials: N
authors.lastname: Bozkurt
authors.affiliation: a Department of Endocrinology and Metabolism .
authors.forename: Fusun B
authors.initials: FB
authors.lastname: Toruner
authors.affiliation: a Department of Endocrinology and Metabolism .
authors.forename: Mujde
authors.initials: M
authors.lastname: Akturk
authors.affiliation: a Department of Endocrinology and Metabolism .
authors.forename: Nuri
authors.initials: N
authors.lastname: Cakir
authors.affiliation: a Department of Endocrinology and Metabolism .
authors.forename: Metin
authors.initials: M
authors.lastname: Arslan
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007124:Immunoenzyme Techniques; D007333:Insulin Resistance; D011247:Pregnancy; D051149:Selenoprotein P / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D014421:Turkey
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D051149:Selenoprotein P; D014280:Triglycerides; D002784:Cholesterol
keywords: BMI; HDL cholesterol; gestational diabetes mellitus; glucose; lipids; selenoprotein P