title: HPV vaccination to prevent oropharyngeal carcinoma: What can be learned from anogenital vaccination programs?
abstract: Human papillomavirus (HPV) infections are well known causes of anogenital cancers. Recent studies show that HPV also plays a role in oropharyngeal cancer (OPC). A review on the role of HPV vaccination in the prevention of head and neck squamous cell carcinoma (HNSCC) with special emphasis on OPC was conducted and available vaccines and vaccination strategies in HNSCC and OPC are discussed. Prophylactic vaccination is known to be effective for prevention of anogenital HPV infection and precursor lesions in the cervix and anus. While the value of vaccination for prevention of OPC and possibly as an adjuvant treatment is still an open question, evidence to date supports the possibility that HPV vaccination may prove to be effective in reducing the incidence of this malignancy.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: robert.takes@radboudumc.nl.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Takes
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Poznań University of Medical Sciences, Poznan, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wierzbicka
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
authors.forename: Gypsyamber
authors.initials: G
authors.lastname: D'Souza
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Poznań University of Medical Sciences, Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Jackowska
authors.affiliation: Departments of Surgery and Otolaryngology - Head and Neck Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Carl E
authors.initials: CE
authors.lastname: Silver
authors.affiliation: Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain; Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Rodrigo
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Frederik G
authors.initials: FG
authors.lastname: Dikkers
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Kerry D
authors.initials: KD
authors.lastname: Olsen
authors.affiliation: University of Udine School of Medicine, Udine, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rinaldo
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Ruud H
authors.initials: RH
authors.lastname: Brakenhoff
authors.affiliation: Coordinator of the International Head and Neck Scientific Group, Padua, Italy.
authors.forename: Alfio
authors.initials: A
authors.lastname: Ferlito
mesh_terms: D001005:Anus Neoplasms / Q000517:prevention & control; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control*; D003218:Condylomata Acuminata / Q000517:prevention & control; D005260:Female; D014943:Global Health; D006801:Humans; D008297:Male; D009959:Oropharyngeal Neoplasms / Q000517:prevention & control*; D030361:Papillomavirus Infections / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage*; D014565:Urogenital Neoplasms / Q000517:prevention & control; D014611:Vaccination / Q000379:methods*
chemical_list: D053918:Papillomavirus Vaccines
keywords: Cancer; Head and neck; Human papilloma virus; Oropharyngeal; Vaccination