title: Paraneoplastic syndrome-associated neuronal antibodies in adult ADHD.
abstract: A high seroprevalence of Yo antibodies targeting cerebellar Purkinje cells was recently reported in children with attention deficit/hyperactivity disorder (ADHD). We investigated the presence of 8 paraneoplastic neurological syndrome (PNS)-associated antibodies including anti-Yo in 169 adult ADHD patients. No associations between ADHD and serum Yo antibodies or other antibodies associated with PNS were found. However, 10 out of 48 ADHD patient sera analyzed by immunofluorescence presented antibodies targeting cerebellar Purkinje cells. This reactivity probably represents the presence of low levels of antibodies against multiple cellular hitherto unknown antigens with little to no clinical significance.
authors.affiliation: Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. Electronic address: bjorn.haukanes@helse-bergen.no.
authors.forename: Bjørn Ivar
authors.initials: BI
authors.lastname: Haukanes
authors.affiliation: Department of Biomedicine, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
authors.forename: Tor-Arne
authors.initials: TA
authors.lastname: Hegvik
authors.affiliation: Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors.forename: Tilo
authors.initials: T
authors.lastname: Eichler
authors.affiliation: Department of Biomedicine, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
authors.forename: Jan
authors.initials: J
authors.lastname: Haavik
authors.affiliation: Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Neurology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Christian
authors.initials: C
authors.lastname: Vedeler
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000276:immunology*; D051381:Rats; D055815:Young Adult
chemical_list: D001323:Autoantibodies
keywords: ADHD; Attention-deficit/hyperactivity disorder; Paraneoplastic neurological syndrome; Purkinje cells; Yo antibodies