title: Performance of cognitive tests, individually and combined, for the detection of cognitive disorders amongst community-dwelling elderly people with memory complaints: the EVATEM study.
abstract: OBJECTIVE
  Dementia is a leading cause of dependence amongst the aged population. Early identification of cognitive impairment could help to delay advanced stages of dependence. This study aimed at assessing the performance of three neuropsychological tests to detect cognitive disorders in elderly subjects with memory complaints.
  
  
  METHODS
  The EVATEM study is a prospective multicentre cohort with a 1-year follow-up. Subjects with memory complaints were selected during preventive health examinations, and three neuropsychological tests (five-word, cognitive disorders examination, verbal fluency) were administered. Two groups were identified in memory clinics: (i) cognitively healthy individuals (CHI) and (ii) mild cognitive impairment or demented individuals (MCI-DI). Cross-sectional analyses were performed on data at inclusion. The relationship between the diagnosis of MCI-DI/CHI and the neuropsychological tests was assessed using logistic regressions. The performance of the neuropsychological tests, individually and combined, to detect cognitive disorders was calculated.
  
  
  RESULTS
  Of 585 subjects, 31.11% had cognitive disorders (MCI, 176 subjects; DI, six subjects). Amongst the three tests studied, the odds ratio for MCI-DI was higher for the five-word test <10 [odds ratio 3.2 (1.81; 5.63)]. The best performance was observed when the three tests were combined: specificity 90.5% and sensitivity 42.4% compared to respectively 89.2% and 28.3% for the five-word test.
  
  
  CONCLUSIONS
  Despite the poor sensitivity of the five-word test, it seems to be the most adapted for the diagnosis of MCI-DI in older adults with a memory complaint, in prevention centres, taking into account its high specificity and its rapid administration compared to the other tests.
authors.affiliation: Centre d'Examens de Santé de la CPAM du Rhône, Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Vannier-Nitenberg
authors.affiliation: Centre Mémoire de Ressources et de Recherche (CMRR) Lyon, Hôpital des Charpennes, Hospices civils de Lyon, Villeurbanne, France.
authors.forename: V
authors.initials: V
authors.lastname: Dauphinot
authors.affiliation: Centre Technique d'Appui et de Formation des Centres d'Examens de Santé (CETAF), Saint-Etienne, France.|Laboratory EA4607 SNA-EPIS, PRES Lyon, Jean Monnet University of Saint Etienne, Saint Etienne, France.
authors.forename: B
authors.initials: B
authors.lastname: Bongue
authors.affiliation: Centre Technique d'Appui et de Formation des Centres d'Examens de Santé (CETAF), Saint-Etienne, France.
authors.forename: C
authors.initials: C
authors.lastname: Sass
authors.affiliation: Centre Mémoire de Ressources et de Recherche (CMRR) Lyon, Hôpital des Charpennes, Hospices civils de Lyon, Villeurbanne, France.
authors.forename: A
authors.initials: A
authors.lastname: Bathsavanis
authors.affiliation: Centre Mémoire de Ressources et de Recherche (CMRR) Lyon, Hôpital des Charpennes, Hospices civils de Lyon, Villeurbanne, France.|CMRR de Saint Etienne, Service de Neurologie, CHU de Saint Etienne, Saint Etienne Cedex, France.
authors.forename: I
authors.initials: I
authors.lastname: Rouch
authors.affiliation: Centre Technique d'Appui et de Formation des Centres d'Examens de Santé (CETAF), Saint-Etienne, France.
authors.forename: N
authors.initials: N
authors.lastname: Deville
authors.affiliation: Centre Technique d'Appui et de Formation des Centres d'Examens de Santé (CETAF), Saint-Etienne, France.|Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France.
authors.forename: O
authors.initials: O
authors.lastname: Beauchet
authors.affiliation: Centre Mémoire de Ressources et de Recherche (CMRR) Lyon, Hôpital des Charpennes, Hospices civils de Lyon, Villeurbanne, France.|Inserm U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon, France.|University Lyon 1, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Krolak-Salmon
authors.affiliation: Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France.|Filiéris, Caisse Autonome Nationale de la Sécurité Sociale dans les Mines, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Fantino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003704:Dementia / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D057187:Independent Living / Q000706:statistics & numerical data*; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000453:epidemiology; D009483:Neuropsychological Tests
keywords: Alzheimer's disease; cognitive disorders; dementia; early diagnosis; memory complaint; mild cognitive impairment