title: Antihypertensive Effects of Artemisia scoparia Waldst in Spontaneously Hypertensive Rats and Identification of Angiotensin I Converting Enzyme Inhibitors.
abstract: We investigated the antihypertensive effects of Artemisia scoparia (AS) in spontaneously hypertensive rats (SHR). The rats were fed diets containing 2% (w/w) hot water extracts of AS aerial parts for 6 weeks. The AS group had significantly lower systolic and diastolic blood pressure levels than the control group. The AS group also had lower angiotensin I converting enzyme (ACE) activity and angiotensin II content in serum compared to the control group. The AS group showed higher vascular endothelial growth factor and lower ras homolog gene family member A expression levels in kidney compared to the control group. The AS group had significantly lower levels of plasma lipid oxidation and protein carbonyls than the control group. One new and six known compounds were isolated from AS by guided purification. The new compound was determined to be 4'-O-β-D-glucopyranoyl (E)-4-hydroxy-3-methylbut-2-enyl benzoate, based on its nuclear magnetic resonance and electrospray ionization-mass spectroscopy data.
authors.affiliation: Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea. jyongcho@mokpo.ac.kr.
authors.forename: Jeong-Yong
authors.initials: JY
authors.lastname: Cho
authors.affiliation: Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea. adle1004@hanmail.net.
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea. douyoung533@naver.com.
authors.forename: Do Young
authors.initials: DY
authors.lastname: Hwang
authors.affiliation: Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea. bum14b@gmail.com.
authors.forename: Saoraya
authors.initials: S
authors.lastname: Chanmuang
authors.affiliation: Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea. bluelily_bird@yahoo.co.in.
authors.forename: Lily
authors.initials: L
authors.lastname: Jaiswal
authors.affiliation: Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea. ykpark@mokpo.ac.kr.
authors.forename: Yang-Kyun
authors.initials: YK
authors.lastname: Park
authors.affiliation: Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea. sw-chun@hanmail.net.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Park
authors.affiliation: Division of Functional Food & Nutrition, National Academy of Agricultural Sciences, Rural Development Administration (RDA), Jeonbuk 560-500, Korea. foodksy@korea.kr.
authors.forename: So-Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Division of Functional Food & Nutrition, National Academy of Agricultural Sciences, Rural Development Administration (RDA), Jeonbuk 560-500, Korea. kimhrr@korea.kr.
authors.forename: Haeng-Ran
authors.initials: HR
authors.lastname: Kim
authors.affiliation: Department of Food Science & Technology, and Functional Food Research Center, Chonnam National University, Gwangju 500-757, Korea. nutrmoon@jnu.ac.kr.
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Moon
authors.affiliation: Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Jeonnam 534-729, Korea. ksham@mokpo.ac.kr.
authors.forename: Kyung-Sik
authors.initials: KS
authors.lastname: Ham
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology*; D019306:Artemisia / Q000737:chemistry*; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D018482:Muscle, Skeletal / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010936:Plant Extracts; D042461:Vascular Endothelial Growth Factor A; D020742:rhoA GTP-Binding Protein
keywords: ACE inhibitor; Artemisia scoparia; blood pressure; halophyte; phenolics