title: Effect of colchicine on polycystic ovary syndrome: an experimental study.
abstract: OBJECTIVE
  To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Twenty-two Wistar-Albino rats were randomly assigned into four with 8 rats in each group: control group; PCOS only group; PCOS-metformin group and PCOS-colchicine group. PCOS was induced by gavage with letrozole once daily at the concentration of 1 mg/kg orally with 21 consecutive days. After PCOS model assessment, PCOS-metformin group was received metformin orally with 500 mg/kg and PCOS-colchicine group was received colchicine orally with 1 mg/kg for the 35 day. Histopathology of ovaries, circulating estrone (E1), estradiol (E2), total testosterone, androstenedione and c-reactive protein (CRP) levels were evaluated.
  
  
  RESULTS
  cystic and atretic follicle number was significantly decreased, but CRP and hormone parameters were not significantly changed with colchicine treatment.
  
  
  CONCLUSIONS
  Colchicine has provided histopathological improvement compared with metformin in PCOS rat model.
authors.affiliation: Department of Obstetric and Gynecology, School of Medicine, Mustafa Kemal University, Tayfur Sökmen Kampus, Serinyol, 31000, Hatay, Turkey. ilayozt@gmail.com.
authors.forename: Ilay Ozturk
authors.initials: IO
authors.lastname: Gozukara
authors.affiliation: Department of Pharmacology, School of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Pınar
authors.affiliation: Department of Biochemistry, School of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Oğuzhan
authors.initials: O
authors.lastname: Ozcan
authors.affiliation: Department of Pathology, School of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Tumay
authors.initials: T
authors.lastname: Ozgur
authors.affiliation: Department of Physiology, School of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Dokuyucu
authors.affiliation: Department of Obstetric and Gynecology, School of Medicine, Mustafa Kemal University, Tayfur Sökmen Kampus, Serinyol, 31000, Hatay, Turkey.
authors.forename: Raziye Keskin
authors.initials: RK
authors.lastname: Kurt
authors.affiliation: Department of Obstetric and Gynecology, School of Medicine, Dumlupınar University, Kutahya, Turkey.
authors.forename: Suna Kabil
authors.initials: SK
authors.lastname: Kucur
authors.affiliation: Department of Obstetric and Gynecology, Nenehatun Woman Hospital, Erzurum, Turkey.
authors.forename: Ayşe Nur
authors.initials: AN
authors.lastname: Aksoy
mesh_terms: D000735:Androstenedione / Q000097:blood; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D003078:Colchicine / Q000008:administration & dosage* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008687:Metformin / Q000008:administration & dosage* / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000097:blood; D050257:Tubulin Modulators / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D050257:Tubulin Modulators; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D002097:C-Reactive Protein; D008687:Metformin; D003078:Colchicine
keywords: Colchicine; Metformin; PCOS