title: [Recent advances in the quantification of drug metabolizing enzymes and transporters by proteomic approach].
abstract: With the advance of drug development and research techniques, the drug metabolic processes and mechanism can be more deeply achieved. As the drug metabolism and pharmacokinetics process are mediated by drug metabolizing enzymes and transporters, study of drug metabolizing enzymes and transporters has become an important part for drug development. The traditional immunoassays with low sensitivity and poor specificity can not reflect the accurate expression level of drug metabolizing enzymes and transporters. We now give a brief review on the quantitative study of drug metabolizing enzymes and transporters by mass spectrometry-based proteomic approach.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Yu-ting
authors.initials: YT
authors.lastname: Cong
authors.forename: Liang-hai
authors.initials: LH
authors.lastname: Hu
authors.forename: Jing-kai
authors.initials: JK
authors.lastname: Gu
mesh_terms: D004798:Enzymes / Q000737:chemistry*; D006801:Humans; D008658:Inactivation, Metabolic; D013058:Mass Spectrometry; D026901:Membrane Transport Proteins / Q000737:chemistry*; D010599:Pharmacokinetics; D040901:Proteomics
chemical_list: D004798:Enzymes; D026901:Membrane Transport Proteins