title: Assessing the Influence of Age and Ethnicity on the Association Between Iron Status and Lead Concentration in Blood: Results from the Canadian Health Measures Survey (2007-2011).
abstract: Inverse association has been reported between iron intake and blood lead concentration (PbB) in epidemiological studies. Data on this association at a low dose of lead exposure are scarce, and the potential influence of ethnicity and age has not been previously reported. This study aimed to estimate the relation between serum ferritin, haemoglobin, haematocrit, and mean corpuscular volume and PbB among 6-18-year-old individuals. Data from Canadian Health and Measures Survey (CHMS), cycle 1 (2007-2009) and cycle 2 (2009-2011), were accessed. A household interview followed by a physical examination (including collection of blood) was performed. The quantification of lead and trace elements in blood was performed by inductively coupled plasma mass spectrometry. The mean PbB was 0.79 μg/dL (95 % confidence interval (95 % CI) 0.75-0.82). Except for haemoglobin levels, no association was found between PbB and any of the parameters of iron status, independently of age. A significant interaction was observed between ferritin levels and ethnicity in relation to PbB (p = 0.07). We found a little evidence of an association between iron status and PbB in the whole sample of subjects aged 6-18 years exposed to low levels of environmental lead. The significant interaction observed between ferritin levels and ethnicity in relation to BPb suggests that the influence of ferritin levels on lead uptake may change by ethnicity, even at low exposure.
authors.affiliation: Population Health and Optimal Health Practices Research Unit, CHUQ Research Center, Faculty of Medicine, Laval University, 2875 Bld Laurier, Delta II (Floor 6), Quebec, QC, G1V 2M2, Canada. Ngueta@hotmail.com.|Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, Montreal, H3T 1A8, QC, Canada. Ngueta@hotmail.com.
authors.forename: Gerard
authors.initials: G
authors.lastname: Ngueta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D002170:Canada; D002648:Child; D005006:Ethnicity; D005260:Female; D005293:Ferritins / Q000097:blood; D006306:Health Surveys; D006801:Humans; D007501:Iron / Q000097:blood*; D007854:Lead / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D008055:Lipids; D007854:Lead; D005293:Ferritins; D007501:Iron; D002118:Calcium
keywords: Age; Blood lead levels; Ethnicity; Iron status