title: 11 Years Later-Isolated Testicular Relapse of ALL After Stem Cell Transplantation Treated With Surgery Only: A Case Report and Review of the Literature.
abstract: Despite advances in therapy for childhood acute lymphoblastic leukemia (ALL), relapses continue to occur and are associated with significant morbidity and mortality. Individuals who relapse after stem cell transplantation (SCT) have an especially poor prognosis and typically require intensive systemic therapy to provide any chance of cure. The majority of relapses occur within 2 years following SCT; relapses later than 4 years post SCT are rare. Here we describe an isolated testicular relapse of ALL 11 years after SCT, treated with local control measures only, and review the literature for other cases of very late ALL relapse following SCT.
authors.affiliation: School of Medicine, University of Virginia, Charlottesville, VA.
authors.forename: Rishabh
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Urology, University of Virginia Medical Center, Charlottesville, VA. Electronic address: jtm5se@virginia.edu.
authors.forename: James T
authors.initials: JT
authors.lastname: Mills
authors.affiliation: Department of Pediatrics, Division of Hematology/Oncology, University of Virginia Medical Center, Charlottesville, VA.
authors.forename: William C
authors.initials: WC
authors.lastname: Petersen
authors.affiliation: Department of Urology, University of Virginia Medical Center, Charlottesville, VA.
authors.forename: Sean T
authors.initials: ST
authors.lastname: Corbett
mesh_terms: D000293:Adolescent; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D009919:Orchiectomy / Q000379:methods*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000379:methods*; D013736:Testicular Neoplasms / Q000601:surgery*; D013997:Time Factors; D014184:Transplantation, Homologous