title: Prescription consisting of Vitamin C and Baicalin inhibits tumor growth by enhancing the antioxidant capacity in vivo.
abstract: OBJECTIVE
  To explore the antitumor effect of prescription consisting of Vitamin C (Vc) and Baicalin (PVB).
  
  
  METHODS
  To explore the antitumor effect of PVB, using U14 cervical tumor-bearing mice model was used and the drugs were administrated through the gavages. Spectrophotometry was used to determine the content of superoxide dismutase (SOD), malondialdehyde (MDA) and cytokines IL-2, Il-4 and IFN-γ.
  
  
  RESULTS
  PVB had a better antitumor effect than baicalin and Vc used alone with an inhibition rate of 58.18% (p<0.05); PVB significantly improved the spleen index (p<0.01), and significantly reduced MDA content (p<0.01) but increased SOD activity in liver tissue and serum (p<0.01).
  
  
  CONCLUSIONS
  PVB shows better antitumor effect than Vc and baicalin used alone, and it can significantly enhance the immunity and antioxidant capacity of the mice.
authors.affiliation: Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Shi
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Haizhao
authors.initials: H
authors.lastname: Zhang
authors.forename: Chengbiao
authors.initials: C
authors.lastname: Lu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000032:analysis; D005419:Flavonoids / Q000008:administration & dosage*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D016207:Cytokines; D005419:Flavonoids; C038044:baicalin; D013482:Superoxide Dismutase; D001205:Ascorbic Acid