title: Multivalent Glycopolymer-Coated Gold Nanoparticles.
abstract: Glycosylated noble metal nanoparticles are a useful tool for probing biological binding events due to their aggregation-induced color changes, particularly for lectins that have multiple binding sites. To overcome the challenges of colloidal instability, which leads to false-positive results, it is essential to add polymeric coatings to these particles. Here we describe a versatile, and reliable, approach to enable coating of gold nanoparticles using well-defined polymers, with carbohydrate end groups. This produces multivalent nanoparticles that are both colloidally stable, but still retain their rapid colorimetric responses to lectin binding.
authors.affiliation: Department of Chemistry, The University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
authors.forename: Sarah-Jane
authors.initials: SJ
authors.lastname: Richards
authors.affiliation: Department of Chemistry, The University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
authors.forename: Caroline I
authors.initials: CI
authors.lastname: Biggs
authors.affiliation: Department of Chemistry, The University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. m.i.gibson@warwick.ac.uk.
authors.forename: Matthew I
authors.initials: MI
authors.lastname: Gibson
mesh_terms: D003102:Colloids; D003124:Colorimetry; D006001:Glycoconjugates / Q000737:chemistry*; D006046:Gold; D037102:Lectins / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D003102:Colloids; D006001:Glycoconjugates; D037102:Lectins; D011108:Polymers; D006046:Gold
keywords: Glycopolymers; Gold nanoparticle s; Lectins; RAFT polymerization