title: Induced Pluripotent Stem Cells and Periodontal Regeneration.
abstract: Periodontitis is a chronic inflammatory disease which leads to destruction of both the soft and hard tissues of the periodontium. Tissue engineering is a therapeutic approach in regenerative medicine that aims to induce new functional tissue regeneration via the synergistic combination of cells, biomaterials, and/or growth factors. Advances in our understanding of the biology of stem cells, including embryonic stem cells and mesenchymal stem cells, have provided opportunities for periodontal tissue engineering. However, there remain a number of limitations affecting their therapeutic efficiency. Due to the considerable proliferation and differentiation capacities, recently described induced pluripotent stem cells (iPSCs) provide a new way for cell-based therapies for periodontal regeneration. This review outlines the latest status of periodontal tissue engineering and highlights the potential use of iPSCs in periodontal tissue regeneration.
authors.affiliation: Shandong provincial key laboratory of oral tissue regeneration, Department of Periodontology, School of Stomatology, Shandong University, No.44-1 West Wenhua Rd., Jinan, 250012 People's Republic of China.
authors.forename: Mi
authors.initials: M
authors.lastname: Du
authors.affiliation: Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong University, No.324 Jingwu Rd., Jinan, 250000 People's Republic of China.
authors.forename: Xuejing
authors.initials: X
authors.lastname: Duan
authors.affiliation: Shandong provincial key laboratory of oral tissue regeneration, Department of Periodontology, School of Stomatology, Shandong University, No.44-1 West Wenhua Rd., Jinan, 250012 People's Republic of China.
authors.forename: Pishan
authors.initials: P
authors.lastname: Yang
keywords: Induced pluripotent stem cells; Periodontal regeneration; Tissue engineering