title: Minimizing Blood Loss in Orthopaedic Surgery The Role of Antifibrinolytics.
abstract: Many common orthopaedic procedures are associated with a large volume of blood loss. Antifibrinolytics have a well-elucidated mechanism of action and a long history of clinical use. By inhibiting the enzymatic breakdown of fibrin, there has been a demonstrated ability to decrease total blood loss and reduce postoperative transfusion requirements. Despite substantial use in cardiac surgery, antifibrinolytic use in orthopaedic surgery has been limited due to concerns over the potential for venous thromboembolism. A growing body of evidence demonstrates the medications' efficacy and safety in arthroplasty and spine surgery. Due to the risks associated with allogenic blood transfusions and the limitations of alternative blood conservation strategies, antifibrinolytics are a reasonable strategy in blood conservation programs for patients undergoing major orthopaedic procedures.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Lerman
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Rapp
mesh_terms: D000933:Antifibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D019637:Orthopedic Procedures / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D065227:Transfusion Reaction; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000139:chemically induced
chemical_list: D000933:Antifibrinolytic Agents