title: Local and long-range activation of innate immunity by infection and damage in C. elegans.
abstract: The nematode worm Caenorhabditis elegans lends itself naturally to investigation of innate immunity, from the scale of molecules to the whole animal. Numerous studies have begun to reveal the complex interplay of signalling mechanisms that underlie host defence in C. elegans. We discuss here research that illustrates the connection between cell and tissue-level homeostatic mechanisms and the activation of innate immune signalling pathways. These are woven together to provide a comprehensive organismal protection against perceived threats.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France. Electronic address: ewbank@ciml.univ-mrs.fr.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Ewbank
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France. Electronic address: pujol@ciml.univ-mrs.fr.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Pujol
mesh_terms: D000818:Animals; D001343:Autophagy / Q000276:immunology; D017173:Caenorhabditis elegans / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology / Q000472:pathogenicity; D005786:Gene Expression Regulation / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D063306:Mitophagy / Q000276:immunology; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000472:pathogenicity; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000276:immunology*; D004718:Saccharomycetales / Q000276:immunology / Q000472:pathogenicity; D015398:Signal Transduction
chemical_list: D029742:Caenorhabditis elegans Proteins; D051192:Receptors, Pattern Recognition