title: Correlation of thiamine metabolite levels with cognitive function in the non-demented elderly.
abstract: Thiamine metabolism is critical for glucose metabolism and also vital for brain function, which is susceptible to decline in the elderly. This study aimed to investigate whether thiamine metabolites correlate with cognitive function in the non-demented elderly and their impact factors. Volunteers >60 years old were recruited and their blood thiamine metabolites and Mini-Mental State Examination (MMSE) scores were measured. The apolipoprotein E (APOE) genotype, routine blood parameters, liver and kidney function, and levels of fasting blood glucose and triglycerides were also measured. The results showed that the thiamine diphosphate (TDP) level weakly correlated with MMSE score in the non-demented elderly. Participants with high TDP levels performed better in Recall and Attention and Calculation than those with low TDP. TDP levels were associated with the APOE ε2 allele, body mass index, hemoglobin level, fasting blood glucose, and triglycerides. Our results suggest that TDP, which is easily affected by many factors, impacts cognitive function in the elderly.
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Fei
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Changpeng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
authors.forename: Shaoming
authors.initials: S
authors.lastname: Sang
authors.affiliation: State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Liu
authors.affiliation: Regional Health Service Center of Xujiahui, Xuhui District, Shanghai, 200030, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Regional Health Service Center of Xujiahui, Xuhui District, Shanghai, 200030, China.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Fudan University, Shanghai, 200032, China. zhongcj@163.com.|State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Fudan University, Shanghai, 200032, China. zhongcj@163.com.
authors.forename: Chunjiu
authors.initials: C
authors.lastname: Zhong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics; D002851:Chromatography, High Pressure Liquid; D003071:Cognition / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D060888:Real-Time Polymerase Chain Reaction; D013831:Thiamine / Q000378:metabolism*; D013835:Thiamine Pyrophosphate / Q000097:blood*
chemical_list: D001057:Apolipoproteins E; D013835:Thiamine Pyrophosphate; D013831:Thiamine
keywords: cognitive function; non-demented elderly; thiamine diphosphate