title: Brain MRI findings with vigabatrin therapy: case report and literature review.
abstract: Infantile spasm or West syndrome is a pediatric epileptic disorder characterized by flexor and/or extensor spasms beginning in childhood. Vigabatrin is an effective medical therapy for infantile spasm but has pronounced, potentially worrisome imaging findings in patients receiving therapy. We present the case of an 8-month-old infant with such brain magnetic resonance imaging findings after treatment initiation. In this article, we highlight the imaging changes and discuss the differential diagnosis along with the required follow-up.
authors.affiliation: Department of Radiology, Weill Cornell Medical College of Cornell University, New York, NY; Division of Transplantation-Oncology and Infectious Diseases, Weill Cornell Medical College of Cornell University, New York, NY. Electronic address: kah2025@med.cornell.edu.
authors.forename: Kaiser
authors.initials: K
authors.lastname: Hussain
authors.affiliation: Division of Transplantation-Oncology and Infectious Diseases, Weill Cornell Medical College of Cornell University, New York, NY. Electronic address: thw2003@med.cornell.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
authors.affiliation: Department of Radiology, Weill Cornell Medical College of Cornell University, New York, NY. Electronic address: jlc2008@med.cornell.edu.
authors.forename: J Levi
authors.initials: JL
authors.lastname: Chazen
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D013036:Spasms, Infantile / Q000188:drug therapy* / Q000473:pathology*; D020888:Vigabatrin / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D020888:Vigabatrin
keywords: Brain MRI; Epilepsy; Infantile spasm; Vigabatrin