title: Mammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristics.
abstract: Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland malignancy. We evaluate the clinicopathological characteristics and long-term clinical behaviour of MASCs. A total of 190 primary salivary gland malignancies at a single institution were reviewed along with relevant immunohistochemical and fluorescent in situ hybridisation (FISH) studies to identify MASCs. Nine MASCs were identified predominantly in the parotid with an equal incidence in men and women and mean age of 36 years. The tumour size ranged from 14 to 50 mm (mean 22 mm). MASCs were composed of monotonous cells with vacuolated eosinophilic cytoplasm and a small nucleus with a distinctive nucleolus. All cases showed immunoreactivity with S-100, MUC4, CK7 and mammoglobin, and lacked immunoreactivity with DOG1, p63, CK5/6 and calponin. ETV6 rearrangement was seen in all cases. No mutations were identified using the OncoCarta Panel v1.0 Kit. Follow up was available for 0.4 to 22 years (median 4 years). Intraparotid lymph node involvement and local recurrence were seen in one patient each. There were no distant metastases. MASCs have specific histopathological features and immunohistochemical profile that distinguish them from their mimics. FISH plays a confirmatory role. An indolent long-term clinical course was observed in this cohort despite involvement of intraparotid lymph node and microscopically involved/close margins.
authors.affiliation: 1Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney 2The Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney 3Department of Molecular Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney 4Central Clinical School, The University of Sydney, Sydney, NSW, Australia.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Luk
authors.forename: Christina I
authors.initials: CI
authors.lastname: Selinger
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Eviston
authors.forename: Trina
authors.initials: T
authors.lastname: Lum
authors.forename: Bing
authors.initials: B
authors.lastname: Yu
authors.forename: Sandra A
authors.initials: SA
authors.lastname: O'Toole
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Clark
authors.forename: Ruta
authors.initials: R
authors.lastname: Gupta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D000069295:Mammary Analogue Secretory Carcinoma / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000473:pathology*; D014178:Translocation, Genetic; D055815:Young Adult; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D014408:Biomarkers, Tumor; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D000097764:ETS Translocation Variant 6 Protein