title: NBu4SH provides a convenient source of HS(-) soluble in organic solution for H2S and anion-binding research.
abstract: Hydrogen sulfide (H2S) has gained significant interest within the scientific community due to its expanding roles in different (patho)physiological processes. Despite this importance, the chemical mechanisms by which H2S exerts its action remain under-scrutinized. Biomimetic investigations in organic solution offer the potential to clarify these mechanisms and to delineate the differential reactivity between H2S and HS(-). However, such studies are hampered by the lack of readily-available sources of HS(-) that are soluble in organic solution. Here we present a simple method for preparing analytically pure tetrabutylammonium hydrosulfide (NBu4SH), which we anticipate will be of significant utility to researchers in the H2S and anion-binding communities.
authors.affiliation: Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology, 1253 University of Oregon, Eugene, Oregon 97403-1253, USA. pluth@uoregon.edu.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Hartle
authors.affiliation: Department of Chemistry, University of Texas at San Antonio (UTSA), San Antonio, TX 78249, USA. Zachary.Tonzetich@utsa.edu.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Meininger
authors.affiliation: Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology, 1253 University of Oregon, Eugene, Oregon 97403-1253, USA. pluth@uoregon.edu.
authors.forename: Lev N
authors.initials: LN
authors.lastname: Zakharov
authors.affiliation: Department of Chemistry, University of Texas at San Antonio (UTSA), San Antonio, TX 78249, USA. Zachary.Tonzetich@utsa.edu.
authors.forename: Zachary J
authors.initials: ZJ
authors.lastname: Tonzetich
authors.affiliation: Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology, 1253 University of Oregon, Eugene, Oregon 97403-1253, USA. pluth@uoregon.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Pluth