title: Formal Direct Cross-Coupling of Phenols with Amines.
abstract: The transition-metal-catalyzed amination of aryl halides has been the most powerful method for the formation of aryl amines over the past decades. Phenols are regarded as ideal alternatives to aryl halides as coupling partners in cross-couplings. An efficient palladium-catalyzed formal cross-coupling of phenols with various amines and anilines has now been developed. A variety of substituted phenols were compatible with the standard reaction conditions. Secondary and tertiary aryl amines could thus be synthesized in moderate to excellent yields.
authors.affiliation: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8 (Canada).|School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000 (PR China).
authors.forename: Zhengwang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8 (Canada).
authors.forename: Huiying
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8 (Canada).
authors.forename: Simon A
authors.initials: SA
authors.lastname: Girard
authors.affiliation: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8 (Canada).
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8 (Canada).
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
authors.affiliation: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8 (Canada). cj.li@mcgill.ca.
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Li
keywords: aryl amines; dehydrogenation; hydrogen borrowing; palladium; phenols