title: Uptake of non-invasive prenatal testing in Chinese women: money matters.
abstract: OBJECTIVE
  To determine the influence of free invasive prenatal testing on the uptake of non-invasive prenatal testing (NIPT).
  
  
  METHODS
  Over a 2-year period at a Chinese tertiary prenatal diagnostic unit, women at risk of fetal trisomy were given the option of NIPT or invasive prenatal testing. Invasive prenatal testing was offered free of charge to women with a local Hukou (household registration); however, women without a local Hukou were charged for invasive prenatal testing. Both women with and without a local Hukou were charged for NIPT.
  
  
  RESULTS
  During the first year, 2647 women with a positive trisomy 21 screening test were referred (474 women with a local Hukou and 2173 women without a local Hukou). Only 1.6% of the women with a local Hukou underwent NIPT, while this proportion was 20.6% in the women without a local Hukou. During the second year, the price of NIPT was reduced. The total number of women referred was 3047 (502 women with a local Hukou and 2545 women without a local Hukou). The uptake of NIPT in women without a local Hukou doubled, but the uptake of NIPT remained stable in women with a local Hukou.
  
  
  CONCLUSIONS
  The financial impact on the uptake of NIPT should not be underestimated.
authors.affiliation: Prenatal Diagnostic Centre, Guangzhou Women and Children's Medical Centre affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: J
authors.initials: J
authors.lastname: Han
authors.affiliation: Prenatal Diagnostic Centre, Guangzhou Women and Children's Medical Centre affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhen
authors.affiliation: Prenatal Diagnostic Centre, Guangzhou Women and Children's Medical Centre affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: M
authors.initials: M
authors.lastname: Pan
authors.affiliation: Prenatal Diagnostic Centre, Guangzhou Women and Children's Medical Centre affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.affiliation: Prenatal Diagnostic Centre, Guangzhou Women and Children's Medical Centre affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Y-M
authors.initials: YM
authors.lastname: Ou
authors.affiliation: Prenatal Diagnostic Centre, Guangzhou Women and Children's Medical Centre affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: C
authors.initials: C
authors.lastname: Liao
authors.affiliation: Prenatal Diagnostic Centre, Guangzhou Women and Children's Medical Centre affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China. Electronic address: lidongzhi2013@aliyun.com.
authors.forename: D-Z
authors.initials: DZ
authors.lastname: Li
mesh_terms: D000328:Adult; D000649:Amniocentesis / Q000191:economics / Q000706:statistics & numerical data; D002681:China; D015193:Chorionic Villi Sampling / Q000191:economics / Q000706:statistics & numerical data; D015331:Cohort Studies; D004247:DNA / Q000097:blood*; D003657:Decision Making; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D005820:Genetic Testing / Q000191:economics / Q000706:statistics & numerical data*; D005102:Health Expenditures; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000191:economics / Q000706:statistics & numerical data*; D012189:Retrospective Studies
chemical_list: D004247:DNA
keywords: Aneuploidy; Informed decision making; Mainland China; Non-invasive prenatal testing; Prenatal screening