title: Soluble M6P/IGFIIR in the circulation.
abstract: Soluble M6P/IGFIIR has the potential to be a significant carrier of IGF-II and mannose 6-P proteins in the circulation and play an important role as an antagonist to the cellular receptor. Evidence suggests that soluble receptor plays a role in fetal and childhood growth by opposing the growth stimulatory effects of IGF-II. Maternal serum levels of M6P/IGFIIR are elevated in late pregnancy and the IGF-II:soluble M6P/IGFIIR ratio in cord blood correlates strongly with weight at birth and placental weight suggesting an important role in fetal growth and development. However, elevated soluble receptor levels may also be indicative of disease in later life, such as liver cirrhosis and some tumor types and may be a useful marker for monitoring treatment and progression of the disease. Further investigation of the regulation of this soluble receptor in health and disease is required to fully elucidate its role in the circulation.
authors.affiliation: Kolling Institute of Medical Research, Royal North Shore Hospital and University of Sydney, Sydney, Australia. Electronic address: carolyn.scott@sydney.edu.au.
authors.forename: Carolyn D
authors.initials: CD
authors.lastname: Scott
authors.affiliation: Hospital for Children and Adolescents, Centre for Pediatric Research, University of Leipzig, Leipzig, Germany. Electronic address: Wieland.Kiess@medizin.uni-leipzig.de.
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
mesh_terms: D000818:Animals; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D047109:Fetal Development; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D011247:Pregnancy; D017527:Receptor, IGF Type 2 / Q000097:blood / Q000378:metabolism*
chemical_list: C035170:IGF2 protein, human; D017527:Receptor, IGF Type 2; D007335:Insulin-Like Growth Factor II
keywords: childhood; circulating hormone binding protein; insulin-like growth factor II; mannose-6-phosphate/IGF-II receptor; obesity; receptor