title: Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins.
abstract: In the past century, few areas of biology advanced as much as our understanding of the pathways of intermediary metabolism. Initially considered unimportant in terms of gene regulation, crucial cellular fate changes, cell differentiation, or malignant transformation are now known to involve 'metabolic remodeling' with profound changes in the expression of many metabolic enzyme genes. This review focuses on the recent identification of RNA-binding activity of numerous metabolic enzymes. We discuss possible roles of this unexpected second activity in feedback gene regulation ('moonlighting') and/or in the control of enzymatic function. We also consider how metabolism-driven post-translational modifications could regulate enzyme-RNA interactions. Thus, RNA emerges as a new partner of metabolic enzymes with far-reaching possible consequences to be unraveled in the future.
authors.affiliation: Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Castello
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Electronic address: hentze@embl.de.
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Hentze
authors.affiliation: EMBL-Australia Collaborating Group, Department of Genome Sciences, The John Curtin School of Medical Research, The Australian National University, Acton (Canberra), ACT 2601, Australia; Victor Chang Cardiac Research Institute, Darlinghurst (Sydney), New South Wales 2010, Australia.
authors.forename: Thomas
authors.initials: T
authors.lastname: Preiss
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D011499:Protein Processing, Post-Translational; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D004798:Enzymes; D016601:RNA-Binding Proteins
keywords: RNA; RNA-binding proteins; metabolic enzymes; metabolon; post-transcriptional regulation; post-translational modifications