title: Near-Field High-Energy Spectroscopic Gamma Imaging Using a Rotation Modulation Collimator.
abstract: Certain trace elements are vital to the body and elemental imbalances can be indicators of certain diseases including cancer and liver diseases. Neutron Stimulated Emission Computed Tomography (NSECT) is being developed as spectroscopic imaging technique to non-invasively and non-destructively measure and image elemental concentrations within the body. A region of interest is illuminated via a high-energy beam of neutrons that scatter inelastically with elemental nuclei within the body. The excited nuclei then relax by emitting characteristic gamma rays. Acquiring the gamma spectrum in a tomographic manner allows not only the identification of elements, but also the formation of images representing spatial distributions of specific elements. We are developing a high-energy position-sensitive gamma camera that allows full illumination of the entire region of interest. Because current scintillation crystal based position-sensitive gamma cameras operate in too low of an energy range, we are adapting high-energy gamma imaging techniques used in space-based imaging. A High Purity Germanium (HPGe) detector provides high-resolution energy spectra while a rotating modulation collimator (RMC) placed in front of the detector modulates the incoming signal to provide spatial information. The purpose of this manuscript is to describe the near-field RMC geometry, which varies greatly from the infinite-focus space-based applications, and how it modulates the incident gamma flux. A simple geometric model is presented and then used to reconstruct two-dimensional planar images of both simulated point sources and extended sources.
authors.affiliation: Duke Advanced Imaging Laboratories, Duke University Medical Center, Durham, NC 27705 ; Department of Radiology, Duke University Medical Center, Durham, NC 27705.
authors.forename: Amy C
authors.initials: AC
authors.lastname: Sharma
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC 27705.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Turkington
authors.affiliation: Duke Advanced Imaging Laboratories, Duke University Medical Center, Durham, NC 27705 ; Department of Radiology, Duke University Medical Center, Durham, NC 27705.
authors.forename: Georgia D
authors.initials: GD
authors.lastname: Tourassi
authors.affiliation: Duke Advanced Imaging Laboratories, Duke University Medical Center, Durham, NC 27705 ; Department of Radiology, Duke University Medical Center, Durham, NC 27705.
authors.forename: Carey E
authors.initials: CE
authors.lastname: Floyd
keywords: Biomedical imaging; Gamma-ray spectroscopy; Neutrons; Nuclear Imaging