title: The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results.
abstract: The Cooperative Health Research In South Tyrol (CHRIS) study is a population-based study with a longitudinal lookout to investigate the genetic and molecular basis of age-related common chronic conditions and their interaction with life style and environment in the general population. All adults of the middle and upper Vinschgau/Val Venosta are invited, while 10,000 participants are anticipated by mid-2017. Family participation is encouraged for complete pedigree reconstruction and disease inheritance mapping. After a pilot study on the compliance with a paperless assessment mode, computer-assisted interviews have been implemented to screen for conditions of the cardiovascular, endocrine, metabolic, genitourinary, nervous, behavioral, and cognitive system. Fat intake, cardiac health, and tremor are assessed instrumentally. Nutrient intake, physical activity, and life-course smoking are measured semi-quantitatively. Participants are phenotyped for 73 blood and urine parameters and 60 aliquots per participant are biobanked (cryo-preserved urine, DNA, and whole and fractionated blood). Through liquid-chromatography mass-spectrometry analysis, metabolite profiling of the mitochondrial function is assessed. Samples are genotyped on 1 million variants with the Illumina HumanOmniExpressExome array and the first data release including 4570 fully phenotyped and genotyped samples is now available for analysis. Participants' follow-up is foreseen 6 years after the first visit. The target population is characterized by long-term social stability and homogeneous environment which should both favor the identification of enriched genetic variants. The CHRIS cohort is a valuable resource to assess the contribution of genomics, metabolomics, and environmental factors to human health and disease. It is awaited that this will result in the identification of novel molecular targets for disease prevention and treatment.
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy. cristian.pattaro@eurac.edu.
authors.forename: Cristian
authors.initials: C
authors.lastname: Pattaro
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Martin
authors.initials: M
authors.lastname: Gögele
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Deborah
authors.initials: D
authors.lastname: Mascalzoni
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Melotti
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Christine
authors.initials: C
authors.lastname: Schwienbacher
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: De Grandi
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Foco
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Yuri
authors.initials: Y
authors.lastname: D'Elia
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Linder
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Fuchsberger
authors.affiliation: Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK.
authors.forename: Cosetta
authors.initials: C
authors.lastname: Minelli
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Clemens
authors.initials: C
authors.lastname: Egger
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Kofink
authors.affiliation: Functional MR Unit, Policlinico S. Orsola, Malpighi Bologna, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Zanigni
authors.affiliation: Dermatological Practice, Kirchplatz 3, 87059, Immenstadt, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Schäfer
authors.affiliation: The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.
authors.forename: Maurizio F
authors.initials: MF
authors.lastname: Facheris
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Sigurður V
authors.initials: SV
authors.lastname: Smárason
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rossini
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Hicks
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy.|Hospital of Schlanders/Silandro, Schlanders/Silandro, Italy.
authors.forename: Helmuth
authors.initials: H
authors.lastname: Weiss
authors.affiliation: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC) (Affiliated to the University of Lübeck, Lübeck, Germany), Via Galvani 31, 39100, Bolzano/Bozen, Italy. peter.pramstaller@eurac.edu.|Department of Neurology, Central Hospital, Bolzano, Italy. peter.pramstaller@eurac.edu.|Department of Neurology, University of Lübeck, Lübeck, Germany. peter.pramstaller@eurac.edu.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Pramstaller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018070:Biological Specimen Banks; D001798:Blood Proteins / Q000378:metabolism; D004777:Environment; D004992:Ethics, Medical; D059472:Exome; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006304:Health Status; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D010375:Pedigree; D010641:Phenotype; D010865:Pilot Projects; D012107:Research Design; D012984:Software; D011795:Surveys and Questionnaires; D016482:Urinalysis; D055815:Young Adult
chemical_list: D001798:Blood Proteins