title: Double trouble: a patient with both HLA-B27 anterior uveitis and HLA-A29 birdshot chorioretinitis.
abstract: BACKGROUND
  Birdshot chorioretinitis (BSCR) is a rare ocular inflammatory disorder associated with HLA-A29 and characterized by bilateral choroidal lesions, vitritis, macular edema, and retinal vasculitis. Ocular inflammation associated with HLA-B27 is typically a recurrent, unilateral, acute anterior uveitis (AAU) that is frequently associated with ankylosing spondylitis (AS). To date, there are no reports of patients with both HLA-A29-positive BSCR and HLA-B27 AAU/AS in the English literature.
  
  
  RESULTS
  A 50-year-old man with a history of bilateral anterior uveitis, vitritis, retinal vasculitis, and cream-colored depigmented oval choroidal lesions was found to be HLA-A29 and HLA-B27 positive. His lumbar spine and sacroiliac joint films revealed fusion of the spine, known as 'bamboo spine' compatible with the diagnosis of ankylosing spondyloarthropathy. He had chronic ocular inflammation that was difficult to control with systemic steroids and immunomodulatory agents.
  
  
  CONCLUSIONS
  This is the only report of a patient with both HLA-A29-positive BSCR and HLA-B27-positive AS and associated anterior uveitis. The severity of his disease suggests that patients who test positive for both HLA-A29 and HLA-B27 carry a poor visual prognosis. Prompt diagnosis and treatment with local or systemic corticosteroids or steroid-sparing agents may control the disease.
authors.affiliation: Department of Ophthalmology, University of Virginia, 1300 Jefferson Park Avenue, PO Box 800715, Charlottesville, VA, 22908, USA. zah3q@hscmail.mcc.virginia.edu.
authors.forename: Zeina
authors.initials: Z
authors.lastname: Haddad
authors.affiliation: Department of Ophthalmology, University of Virginia, 1300 Jefferson Park Avenue, PO Box 800715, Charlottesville, VA, 22908, USA. AKR5U@hscmail.mcc.virginia.edu.
authors.forename: Ashvini
authors.initials: A
authors.lastname: Reddy
keywords: Ankylosing spondyloarthropathy; Birdshot chorioretinitis; Cystoid macular edema; Panuveitis; Seronegative spondyloarthropathy