title: Long-term visual acuity outcomes in patients with uveal melanoma treated with 125I episcleral OSU-Nag plaque brachytherapy.
abstract: OBJECTIVE
  To report our experience in long-term follow-up of ocular melanoma patients treated with custom OSU-Nag eye plaques using (125)I sources.
  
  
  METHODS
  A retrospective chart review was conducted for 113 consecutive ocular melanoma patients with follow-up visual acuity data who were treated with OSU-Nag plaque episcleral brachytherapy at The Ohio State University Medical Center from 1994 to 2009. Visual acuity, complication data, and recurrence rates were recorded up to 120 months after brachytherapy.
  
  
  RESULTS
  Median age at presentation was 63.0 years (range, 22-93). Median follow-up was 65.5 months (range, 2-180). Median radiation dose at the prescription point was 85.8 Gy (range, 51.8-103.7). Preservation of useful visual acuity, defined as better than 20/200, was noted in 43 of 74 (58%) of patients in the present study at 36 months compared with 50.1% of Collaborative Ocular Melanoma Study participants. By 120 months, 17 of 30 (57%; 95% confidence interval, 45-69%) progressed to visual acuity worse than 20/200, whereas 9 of 30 (30%) retained visual acuity of 20/40 or better, and 4 of 30 (13%) were 20/50-20/200. The rate of retinopathy after radiation was approximately 40% of all those observed by 60 months. Baseline visual acuity, apical tumor height, American Joint Committee on Cancer tumor category, and distance between the tumor and the fovea were all significantly associated with loss of visual acuity. The local tumor control rate by 60 months of follow-up was 93% (95% confidence interval, 85-97%).
  
  
  CONCLUSIONS
  The OSU-Nag custom (125)I plaque is an effective treatment for uveal melanoma, with preservation of useful visual acuity in 58% of eyes 3 years after treatment and 43% of eyes 10 years after treatment.
authors.affiliation: Department of Ophthalmology and Visual Science, Havener Eye Institute, The Ohio State University Wexner Medical Center, Columbus, OH.
authors.forename: C Ellis
authors.initials: CE
authors.lastname: Wisely
authors.affiliation: Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH.
authors.forename: Mersiha
authors.initials: M
authors.lastname: Hadziahmetovic
authors.affiliation: Department of Ophthalmology and Visual Science, Havener Eye Institute, The Ohio State University Wexner Medical Center, Columbus, OH.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Reem
authors.affiliation: Center for Biostatistics, Department of Bioinformatics, The Ohio State University Wexner Medical Center, Columbus, OH.
authors.forename: Erinn M
authors.initials: EM
authors.lastname: Hade
authors.affiliation: Department of Radiation Oncology, Northern California Kaiser Permanente, Santa Clara, CA.
authors.forename: Subir
authors.initials: S
authors.lastname: Nag
authors.affiliation: Department of Ophthalmology and Visual Science, Havener Eye Institute, The Ohio State University Wexner Medical Center, Columbus, OH.
authors.forename: Frederick H
authors.initials: FH
authors.lastname: Davidorf
authors.affiliation: Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH. Electronic address: Douglas.Martin@osumc.edu.
authors.forename: Douglas
authors.initials: D
authors.lastname: Martin
authors.affiliation: Department of Ophthalmology and Visual Science, Havener Eye Institute, The Ohio State University Wexner Medical Center, Columbus, OH.
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Cebulla
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology*; D012164:Retinal Diseases / Q000209:etiology*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000532:radiotherapy*; D014792:Visual Acuity / Q000528:radiation effects*; D055815:Young Adult; D000098943:Uveal Melanoma
chemical_list: D007457:Iodine Radioisotopes
keywords: Brachytherapy; Collaborative ocular melanoma study; OSU-Nag plaque; Uveal melanoma; Visual acuity