title: Incidence of benign prostate hypertrophy in Danish men with and without HIV infection.
abstract: BACKGROUND
  Information on risk of benign prostate hypertrophy (BPH) in HIV-infected men is sparse. We aimed to estimate the incidence of being diagnosed with BPH among HIV-infected men compared with an age and sex-matched comparison cohort from the background population. To exclude that family-associated risk factors influence risk of BPH diagnoses in families of HIV-infected individuals, we estimated risk of BPH in fathers of HIV-infected men and fathers of the comparison cohort.
  
  
  METHODS
  In a nationwide, population-based, matched cohort study, we calculated incidence rates and used Poisson regression models to calculate incidence rate ratios (IRRs) of being diagnosed with BPH, defined as the earliest of date of the second redeemed prescription of a drug used to treat BPH, the first registration of a BPH diagnosis in the Danish National Hospital Registry (DNHR) or the first registration of a surgical procedure for BPH in DNHR.
  
  
  RESULTS
  We identified 4633 HIV-infected men, 46 330 comparison cohort individuals, 1585 fathers of HIV-infected men and 20 449 fathers of the comparison cohort. Incidence rate of being diagnosed with BPH was 37.0 [95% confidence interval (95% CI) 31.5-43.1] per 10 000 person-years of follow-up among HIV-infected men and was not increased compared with the comparison cohort (IRR 1.04, 95% CI 0.88-1.22). Risk was not increased for fathers of HIV-infected men vs. fathers of the comparison cohort (IRR 0.99, 95% CI 0.87-1.12). Stratified analyses did not change the above results markedly.
  
  
  CONCLUSIONS
  HIV-infected individuals do not have an increased risk of being diagnosed with BPH.
authors.affiliation: aDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet bDepartment of Infectious Diseases, Copenhagen University Hospital, Hvidovre cDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus dDepartment of Infectious Diseases, Odense University Hospital, Odense, eDepartment of Infectious Diseases, Aalborg University Hospital, Aalborg fFaculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Magnus Glindvad
authors.initials: MG
authors.lastname: Ahlström
authors.forename: Gitte
authors.initials: G
authors.lastname: Kronborg
authors.forename: Carsten S
authors.initials: CS
authors.lastname: Larsen
authors.forename: Court
authors.initials: C
authors.lastname: Pedersen
authors.forename: Gitte
authors.initials: G
authors.lastname: Pedersen
authors.forename: Jan
authors.initials: J
authors.lastname: Gerstoft
authors.forename: Niels
authors.initials: N
authors.lastname: Obel
mesh_terms: D000328:Adult; D000368:Aged; D003718:Denmark / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000453:epidemiology*; D018570:Risk Assessment