title: Total Synthesis and Tentative Structural Elucidation of Cryptomoscatone E3: Interplay of Experimental and Computational Studies.
abstract: A successful combination of computational chemistry and total synthesis was explored to tentatively elucidate the absolute configuration of cryptomoscatone E3, a polyketide isolated from the Brazilian tree Cryptocarya mandiocanna. Two independent synthetic approaches are discussed based on asymmetric allylation, ring closing metathesis, and aldol reactions.
authors.affiliation: Departamento de Química Orgânica, Instituto de Química, Universidade Estadual de Campinas (Unicamp) , CP 6154, CEP 13084-971, Campinas, SP Brazil.
authors.forename: Luiz F T
authors.initials: LF
authors.lastname: Novaes
authors.affiliation: Instituto de Química Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET , Suipacha 531, S2002LRK Rosario, Argentina.
authors.forename: Ariel M
authors.initials: AM
authors.lastname: Sarotti
authors.affiliation: Departamento de Química Orgânica, Instituto de Química, Universidade Estadual de Campinas (Unicamp) , CP 6154, CEP 13084-971, Campinas, SP Brazil.
authors.forename: Ronaldo A
authors.initials: RA
authors.lastname: Pilli