title: pH-Triggered SrTiO3:Er Nanofibers with Optically Monitored and Controlled Drug Delivery Functionality.
abstract: The design of multifunctional localized drug delivery systems (LDDSs) has been endeavored in the past decades worldwide. The matrix material of LDDSs is known as a crucial factor for the success of its transformation from the laboratory to clinical practices. Herein, a biocompatible ceramic, strontium titanate (SrTiO3, STO), was utilized as the matrix. A variety of fine Er doped SrTiO3 (STO:Er) nanofibers were fabricated via electrospinning. After the surface functionalization with amino groups, the drug loading capacity of STO:Er nanofibers is dramatically increased. The nanofibers present a rather sustained drug releasing behavior in the media with pH of 7.4, and the release kinetics is significantly accelerated with the decreased pH value from 7.4 to 4.7. Furthermore, the intensity of the spectrum emitted from the STO:Er nanofibers corresponds well with the drug releasing progress under the excitation of near-infrared spectrum (∼980 nm). Fast drug release behavior (in an acid environment) induces a rapid intensity enhancing effect of photoluminescence emission and vice versa. The main mechanism is attributed to the quenching effect induced by the C-Hx groups of IBU molecules with vibration frequencies from 2850 to 3000 cm(-1). Such new STO:Er nanofibers with pH-triggered and optically monitored drug delivery functionalities have therefore been considered as another new localized drug delivery platform for modern tumor diagnosis and therapy.
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Yike
authors.initials: Y
authors.lastname: Fu
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310009, P. R. China.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Weng
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou, Zhejiang 310027, P. R. China.|Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma , 101 Stephenson Parkway, Norman, Oklahoma 73019-5300, United States.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
authors.affiliation: State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University , Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Gaorong
authors.initials: G
authors.lastname: Han
mesh_terms: D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D004871:Erbium / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000494:pharmacology; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013324:Strontium / Q000737:chemistry*; D013818:Thermogravimetry; D014025:Titanium / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D010087:Oxides; D004871:Erbium; D014025:Titanium; C119252:strontium titanium oxide; D007052:Ibuprofen; D013324:Strontium
keywords: SrTiO3:Er nanofibers; drug delivery; electrospinning; optical monitoring; pH-triggered