title: Crofelemer for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on anti-retroviral therapy.
abstract: Chronic diarrhea remains a common condition that affects people infected with human immunodeficiency virus (HIV) despite the widespread use of potent antiretroviral therapy. It is important that providers control this condition, as the persistence of diarrhea affects the quality of life of patients and may contribute to decreased adherence to antiretroviral therapy. Strategies to control diarrhea in patients with HIV infection include switching to a new antiretroviral regimen and/or the use of specific medications to control the diarrhea. This review aims to provide a concise evaluation of a newly approved medication (crofelemer) that has a novel mechanism of action and has received approval for the symptomatic relief of non-infectious diarrhea in adult patients with HIV on anti-retroviral therapy.
authors.affiliation: a 1 Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine , Miami, FL, USA.|b 2 Clinical Research Building , 1120 NW 14th Street, Suite 857, Miami, FL 33136, USA.
authors.forename: Jose G
authors.initials: JG
authors.lastname: Castro
authors.affiliation: c 3 Clinical Hospital Pharmacist, Pharmacy Department, Jackson Memorial Hospital , Miami, FL, USA.
authors.forename: Nafeesa
authors.initials: N
authors.lastname: Chin-Beckford
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000930:Antidiarrheals / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D055118:Medication Adherence; D044945:Proanthocyanidins / Q000494:pharmacology / Q000627:therapeutic use*; D011788:Quality of Life
chemical_list: D019380:Anti-HIV Agents; D000930:Antidiarrheals; D044945:Proanthocyanidins; C546704:crofelemer
keywords: AIDS; HIV; crofelemer; diarrhea; secretory diarrhea; side effects antiretrovirals; treatment diarrhea