title: Neuropathic pain in patients with haemophilia, that is the question.
abstract: Chronic pain caused by recurrent joint bleedings affects a large number of patients with haemophilia (PwH). The basis of this pain, nociceptive or neuropathic, has not been investigated so far. In other pain-related chronic disorders such as osteoarthritis or rheumatoid arthritis, initial studies showed nociceptive but also neuropathic pain features. 137 PwH and 33 controls (C) completed the painDETECT-questionnaire (pDq), which identifies neuropathic components in a person´s pain profile. Based on the pDq results, a neuropathic pain component is classified as positive, negative or unclear. A positive neuropathic pain component was found in nine PwH, but not in C. In 20 PwH an unclear pDq result was observed. In comparison to C the allocation of pDq results is statistically significant (p≤0.001). Despite various pDq results in PwH and C a similar appraisal pain quality, but on a different level, was determined. Summarising the results, there is a potential risk to misunderstand underlying pain mechanisms in PwH. In chronic pain conditions based on haemophilic arthopathy, a differential diagnosis seems to be unalterable for comprehensive and individualised pain management in PwH.
authors.forename: S
authors.initials: S
authors.lastname: Krüger
authors.affiliation: Prof. Thomas Hilberg, Bergische Universität Wuppertal / Lehrstuhl für Sportmedizin, Pauluskirchstraße 7, 42284 Wuppertal, E-mail: hilberg@uni-wuppertal.de.
authors.forename: T
authors.initials: T
authors.lastname: Hilberg
mesh_terms: D000328:Adult; D000368:Aged; D015984:Causality; D059350:Chronic Pain / Q000175:diagnosis* / Q000453:epidemiology*; D015897:Comorbidity; D005858:Germany / Q000453:epidemiology; D006467:Hemophilia A / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000175:diagnosis* / Q000453:epidemiology*; D010147:Pain Measurement / Q000706:statistics & numerical data*; D012307:Risk Factors; D057566:Self Report; D055815:Young Adult
keywords: Haemophilia; neuropathic; nociceptive; pain