title: The Hedgehog Hold on Homeostasis.
abstract: The adult lung is largely quiescent, with airway epithelia turning over slowly. Peng et al. (2015) describe a key role for the Hedgehog pathway in actively maintaining this quiescence, a surprising turn of events given the pathway's established mitogenic role, and they show that Hedgehog pathway attenuation is required for proliferative regeneration.
authors.affiliation: Department of Translational Oncology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Ciara
authors.initials: C
authors.lastname: Metcalfe
authors.affiliation: Department of Discovery Oncology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: siebel.christian@gene.com.
authors.forename: Christian W
authors.initials: CW
authors.lastname: Siebel
mesh_terms: D000818:Animals; D053823:Hedgehog Proteins / Q000378:metabolism*; D008168:Lung / Q000166:cytology* / Q000378:metabolism*; D055370:Lung Injury / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D012038:Regeneration; D014945:Wound Healing
chemical_list: D053823:Hedgehog Proteins