title: Associations of non-invasive measures of arterial structure and function, and traditional indicators of cardiovascular risk in adults with cerebral palsy.
abstract: BACKGROUND
  Persons with cerebral palsy (CP) have mobility limitations and may be at increased risk for cardiovascular disease (CVD).
  
  
  OBJECTIVE
  To determine the feasibility of assessing novel CVD risk indicators and to identify predictors of CVD risk in a clinic-based group of adults with CP.
  
  
  METHODS
  In an observational study, we examined 42 adults with CP (mean age 33.5 ± 12.3 yr). Traditional (resting blood pressure, smoking status and lipids) and novel CVD risk indicators (endothelial function, arterial stiffness, and carotid wall thickness) were assessed.
  
  
  RESULTS
  Measures of endothelial function and central arterial stiffness were conducted in 100% and 83% of participants, respectively. Age was the strongest independent predictor of vascular health (cIMT, Age, R square = 0.576, p = 0.001).
  
  
  CONCLUSIONS
  Non-invasive measures of arterial structure and function are feasible to assess and may assist in the prediction of CVD risk in adults with CP.
authors.affiliation: Department of Kinesiology, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada. Electronic address: mcpheepg@mcmaster.ca.
authors.forename: Patrick G
authors.initials: PG
authors.lastname: McPhee
authors.affiliation: CanChild Centre for Childhood Disability Research, Department of Pediatrics, McMaster University, 1400 Main St. W., Hamilton, ON, L8S 1C7, Canada. Electronic address: gorter@mcmaster.ca.
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: Gorter
authors.affiliation: Department of Kinesiology, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada. Electronic address: cotielm@mcmaster.ca.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Cotie
authors.affiliation: Department of Kinesiology, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada; Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, 1400 Main St. W., Hamilton, ON, L8S 1C7, Canada. Electronic address: timmonbw@mcmaster.ca.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Timmons
authors.affiliation: Department of Medicine, Division of Physical Medicine and Rehabilitation, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada. Electronic address: msksportdoc@hotmail.com.
authors.forename: Todd
authors.initials: T
authors.lastname: Bentley
authors.affiliation: Department of Kinesiology, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada. Electronic address: macdonmj@mcmaster.ca.
authors.forename: Maureen J
authors.initials: MJ
authors.lastname: MacDonald
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D002547:Cerebral Palsy / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003935:Diagnostic Techniques, Cardiovascular; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005240:Feasibility Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D009864:Ontario; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008055:Lipids
keywords: Adult; Arterial stiffness; Cardiovascular health; Carotid intima media thickness; Cerebral palsy; Endothelial function