title: No evidence of asymptomatic variant CJD infection in immunodeficiency patients treated with UK-sourced immunoglobulin.
abstract: Surveillance of 75 immunodeficiency patients exposed to UK-sourced immunoglobulin, including batches derived from donors who went on to develop vCJD, has not detected any clinical cases of vCJD, or of asymptomatic infection in 15 patients with available tissue samples of sufficient quality for testing.
authors.affiliation: Central Manchester University Hospitals, Manchester, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Helbert
authors.affiliation: Central Manchester University Hospitals, Manchester, UK.
authors.forename: C
authors.initials: C
authors.lastname: Bangs
authors.affiliation: National Creutzfeldt-Jakob Disease Research and Surveillance Unit, University of Edinburgh, Edinburgh, UK.
authors.forename: M
authors.initials: M
authors.lastname: Bishop
authors.affiliation: National Creutzfeldt-Jakob Disease Research and Surveillance Unit, University of Edinburgh, Edinburgh, UK.
authors.forename: A
authors.initials: A
authors.lastname: Molesworth
authors.affiliation: National Creutzfeldt-Jakob Disease Research and Surveillance Unit, University of Edinburgh, Edinburgh, UK.
authors.forename: J
authors.initials: J
authors.lastname: Ironside
mesh_terms: D000328:Adult; D058345:Asymptomatic Infections; D001782:Blood Donors; D007562:Creutzfeldt-Jakob Syndrome / Q000635:transmission*; D005838:Genotype; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000473:pathology; D011110:Polymorphism, Genetic; D000072002:Prion Proteins / Q000235:genetics
chemical_list: D016756:Immunoglobulins, Intravenous; C512656:PRNP protein, human; D000072002:Prion Proteins
keywords: immunoglobulins; prions