title: Antinociceptive effects induced by intra-lateral habenula complex injection of the galanin receptor 1 agonist M617 in rats.
abstract: The present study was performed to explore the antinociceptive effects of the galanin receptor 1 agonist M617 in lateral habenula complex in rats. Intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of galanin induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of the galanin receptor 1 agonist M617 also induced dose-dependent increases in HWLs to noxious thermal and mechanical stimulations in rats. Interestingly, there were no significant differences between the antinociceptive effects induced by intra-lateral habenula injection of 2 nmol of M617 and 2 nmol of galanin. The results indicate that galanin receptor 1 may be involved in the galanin-induced antinociceptive effects in the lateral habenula.
authors.affiliation: College of Life Science, ChangChun Normal University, Changchun, 130032, Jilin, People's Republic of China. fulibo000000@126.com.
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Fu
authors.affiliation: College of Life Science, ChangChun Normal University, Changchun, 130032, Jilin, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Life Science, ChangChun Normal University, Changchun, 130032, Jilin, People's Republic of China.
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Sun
authors.affiliation: College of Life Science, ChangChun Normal University, Changchun, 130032, Jilin, People's Republic of China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Liu
authors.affiliation: College of Life Science, ChangChun Normal University, Changchun, 130032, Jilin, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Life Science, ChangChun Normal University, Changchun, 130032, Jilin, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhuang
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001920:Bradykinin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D019004:Galanin / Q000008:administration & dosage* / Q000031:analogs & derivatives; D019262:Habenula / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044091:Receptor, Galanin, Type 1 / Q000819:agonists* / Q000502:physiology*
chemical_list: D000700:Analgesics; C000614145:M617 peptide; D010446:Peptide Fragments; D044091:Receptor, Galanin, Type 1; D019004:Galanin; D001920:Bradykinin
keywords: Antinociceptive effects; Galanin; Galanin receptor 1; Lateral habenula; M617