title: Effects of a single rectal dose of Misoprostol prior to abdominal hysterectomy in women with symptomatic leiomyoma: a randomized double blind clinical trial.
abstract: BACKGROUND
  Fibroma, the most common benign pelvic tumor in women, affects 25 to 30% of women of reproductive age. Primary treatment for patients with symptomatic or large fibroma is surgery.
  
  
  OBJECTIVE
  The purpose of this study was to investigate the effect of a single rectal dose of Misoprostol on bleeding during abdominal hysterectomy.
  
  
  METHODS
  This double blind randomized clinical trial was conducted with 80 candidates for abdominal hysterectomy, due to uterine myoma, in the Shahid Sadoughi hospital of Yazd in 2012. The aim of this study was to assess the effect of single rectal dose of Misoprostol on peri-operational abdominal hysterectomy bleeding. Following administration of 400 micrograms of Misoprostol in the case group (n=40), predetermined criteria were compared with control group (n=40).
  
  
  RESULTS
  Volume of bleeding during the operation was significantly lower in cases where Misoprostol was used. (268.71 ± 156.85 vs. 350.38 ± 152.61 cc in the case and control groups, respectively). Our findings also showed that Hemoglobin (Hb) levels before, 8, and 30 hours following the operation differed significantly (p=0.001), but these changes were similar in both groups. Pre-operative Hb levels were 11.90 ± 1.7 and 11.90 ± 2.0 in the case and control groups, respectively.
  
  
  CONCLUSIONS
  A single rectal dose of Misoprostol has positive effect on reducing peri-operational bleeding in women undergoing abdominal hysterectomy due to symptomatic leiomyoma.
authors.affiliation: Gynecologist, Associated Professor, Gynecology Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Afsarosadat
authors.initials: A
authors.lastname: Tabatabai
authors.affiliation: Gynecology Oncology Fellowship, Assistant Professor, Gynecology Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Karimi-Zarchi
authors.affiliation: Gynecologist, Assistant Professor, Gynecology Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Bahare
authors.initials: B
authors.lastname: Meibodi
authors.affiliation: Medical Student, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Marzie
authors.initials: M
authors.lastname: Vaghefi
authors.affiliation: Medical Student, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Pouria
authors.initials: P
authors.lastname: Yazdian
authors.affiliation: M.Sc. of Health Education, Faculty of Hygiene, Shahid Sadoughi University of Medical Science, Yazd, Iran.
authors.forename: Mahbube
authors.initials: M
authors.lastname: Zeidabadi
authors.affiliation: General Practitioner, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Atefe
authors.initials: A
authors.lastname: Dehghani
authors.affiliation: Medical Student, Young Researchers and Elites Club, Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran.
authors.forename: Soraya
authors.initials: S
authors.lastname: Teimoori
authors.affiliation: Medical Student, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Jamali
authors.affiliation: Medical Student, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Akhondi
keywords: Misoprostol; abdominal hysterectomy; bleeding volume