title: Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure.
abstract: An estimated 35 million people worldwide are infected with HIV, yet a widely applicable cure strategy remains elusive. Recent case reports have suggested that curing HIV infection is possible, renewing excitement about research efforts. We describe those cases and discuss their relevance to the global HIV epidemic. We also review ongoing cure strategies that are transitioning from the lab to the clinic, and the assays and clinical assessments that can be used to evaluate cure interventions.
authors.affiliation: Department of Pharmacology and Molecular Sciences, and.
authors.forename: Alyssa R
authors.initials: AR
authors.lastname: Martin
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; email: rsiliciano@jhmi.edu.|Howard Hughes Medical Institute, Baltimore, Maryland 21205.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Siliciano
mesh_terms: D016915:AIDS Vaccines; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D060740:Disease Eradication; D015316:Genetic Therapy; D006678:HIV / Q000276:immunology / Q000302:isolation & purification; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D055502:Secondary Prevention; D016662:Virus Integration
chemical_list: D016915:AIDS Vaccines; D019380:Anti-HIV Agents
keywords: HIV-1; early treatment; genome editing; persistence; shock and kill; vaccine