title: Reverse left ventricular remodeling: effect of cardiac rehabilitation exercise training in myocardial infarction patients with preserved ejection fraction.
abstract: BACKGROUND
  In the increasingly prevalent population of postmyocardial infarction (MI) patients with preserved left ventricular (LV) ejection fraction (>45%), the effect of cardiac rehabilitation (CR) exercise training on LV structure and function is unknown.
  
  
  OBJECTIVE
  To examine the reverse LV remodeling effect of CR exercise training in post-MI patients with preserved LV ejection fraction (>45%).
  
  
  METHODS
  Prospective, longitudinal, controlled trial.
  
  
  METHODS
  Outpatient CR programme.
  
  
  METHODS
  Fifty six asymptomatic, post-MI patients without residual myocardial ischemia and LV ejection fraction >45%.
  
  
  METHODS
  Within 3-6 weeks of MI, and 10 weeks later, echocardiography and cardiopulmonary exercise testing were performed. An exercise training group (N.=36) completed twice weekly gym based cardiovascular exercise (60-80% VO2 peak) and a resistance training programme, whilst a non-exercise group (N.=20) did not.
  
  
  RESULTS
  In comparison to the non-exercise group, in which there was no change, 10 weeks of CR exercise training resulted in increased VO2peak and reduced LV end diastolic and systolic volumes (all P<0.05 vs. non-exercise group).
  
  
  CONCLUSIONS
  In post-MI patients with preserved LV ejection fraction (>45%), CR exercise training is effective in improving functional capacity and reducing LV volumes.
  
  
  CONCLUSIONS
  In this previously unstudied population, the measurement of reverse LV volumetric remodeling may prove useful as an indicator of CR exercise programme efficacy. To maximize the potential clinical benefit from reverse LV remodeling, this patient group, should be actively encouraged to engage in CR exercise training.
authors.affiliation: Cardiff Metropolitan University, Cardiff, England - gordon.mcgregor@uhcw.nhs.uk.
authors.forename: Gordon
authors.initials: G
authors.lastname: McGREGOR
authors.forename: David
authors.initials: D
authors.lastname: Gaze
authors.forename: David
authors.initials: D
authors.lastname: Oxborough
authors.forename: Jamie
authors.initials: J
authors.lastname: O'Driscoll
authors.forename: Rob
authors.initials: R
authors.lastname: Shave
mesh_terms: D015415:Biomarkers / Q000032:analysis; D000072038:Cardiac Rehabilitation; D004562:Electrocardiography; D015444:Exercise; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000534:rehabilitation*; D011446:Prospective Studies; D013318:Stroke Volume; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015415:Biomarkers