title: DEVELOPMENT OF CHRONIC SUBRETINAL FLUID IN KEARNS-SAYRE SYNDROME.
abstract: OBJECTIVE
  To report a novel ophthalmic finding of the development of chronic subretinal fluid in a patient with Kearns-Sayre syndrome.
  
  
  METHODS
  An observational case report with funduscopic, angiographic, neurophysiologic, and optical coherence tomographic correlation.
  
  
  RESULTS
  An 11-year-old male with bilateral hearing loss, cerebellar dysfunction, short stature, low weight, ptosis, external ophthalmoplegia, and pigmentary retinopathy of both eyes developed chronic subretinal fluid below the central macula. This fluid has remained for more than 1.5 years. Genetic testing revealed a heteroplasmic 7,797 base pair mitochondrial deletion (m. 7638-1543del7797).
  
  
  CONCLUSIONS
  The authors report a novel physical finding of subfoveal fluid in a patient with Kearns-Sayre syndrome. The pathophysiologic etiology of this fluid and its localization to the subfoveal retina remains unclear. Patients with pigmentary retinopathy related to mitochondrial disorders should be monitored for the development of subretinal fluid, which can contribute to vision loss.
authors.affiliation: Retina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Yannis M
authors.initials: YM
authors.lastname: Paulus
authors.forename: Adam S
authors.initials: AS
authors.lastname: Wenick
mesh_terms: D002648:Child; D006801:Humans; D007625:Kearns-Sayre Syndrome / Q000150:complications*; D008297:Male; D012174:Retinitis Pigmentosa / Q000209:etiology*; D058471:Subretinal Fluid / Q000000981:diagnostic imaging