title: Conservation of gene and tissue networks regulating insulin signalling in flies and vertebrates.
abstract: Fruit flies have emerged as a powerful tool to investigate metabolism. Not only are gene structures and gene networks that control metabolism conserved through evolution, but the interactions among organs to store and process metabolites have strong similarities between flies and humans. Accordingly, the Drosophila system has the potential to address human disorders associated with metabolic dysfunction including obesity, type 2 diabetes and lipotoxicity.
authors.affiliation: Division of Molecular Biology and Biochemistry, School of Biological Sciences University of Missouri-Kansas City Kansas City, MO 64110, U.S.A.
authors.forename: Rahul
authors.initials: R
authors.lastname: Das
authors.affiliation: Division of Molecular Biology and Biochemistry, School of Biological Sciences University of Missouri-Kansas City Kansas City, MO 64110, U.S.A. dobensl@umkc.edu.
authors.forename: Leonard L
authors.initials: LL
authors.lastname: Dobens
mesh_terms: D000818:Animals; D005075:Biological Evolution; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D009765:Obesity / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D014714:Vertebrates / Q000235:genetics / Q000378:metabolism*
keywords: drosophila insulin signalling; review