title: Resistance exercise training increase activation of AKT-eNOS and Ref-1 expression by FOXO-1 activation in aorta of F344 rats.
abstract: OBJECTIVE
  This study investigated the effects of resistance exercise on the Akt-eNOS, the activation of antioxidant protein and FOXO1 in the aorta of F344 rats.
  
  
  METHODS
  Male 7 week-old F344 rats were randomly divided into 2 groups: a climbing group (n = 6) and a sedentary group (n = 6). H&E staining and western blotting were used to analyze the rat aortas and target proteins.
  
  
  RESULTS
  Resistance exercise training did not significantly affect aortic structure. Phosphorylation of AKT and eNOS and expression of MnSOD and Ref-1 were significantly increased while FOXO1 phosphorylation was significantly decreased in the resistance exercise group compared with the sedentary group.
  
  
  CONCLUSIONS
  We demonstrate that resistance exercise activates the Akt-eNOS and Ref-1 protein without changes to aortic thickness via FOXO-1 activation in the aorta of F344 rats.
authors.affiliation: Department of Sports Science, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Sports Science, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Sports Science, Hannam University, Daejeon, Republic of Korea.
authors.forename: Jin-Hwan
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of physiology, Chungnam National University, Deajeon, Republic of Korea.
authors.forename: Byeong Hwa
authors.initials: BH
authors.lastname: Jeon
authors.affiliation: Department of Sports Science, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Sang Ki
authors.initials: SK
authors.lastname: Lee
keywords: FOXO1; MnSOD; Ref-1; aorta structure; oxidative stress; resistance exercise