title: Predictive value of blood lipid association with response to neoadjuvant chemoradiotherapy in colorectal cancer.
abstract: The aim of this research was to explore whether blood lipid parameters could predict tumor regression grading (TRG) and compare with the predictive value of carcinoembryonic antigen (CEA) in patients with locally advanced colorectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT). Between June 2011 and January 2015, the records of 176 patients with primary colorectal adenocarcinoma treated with nCRT followed by radical surgery were reviewed retrospectively. Total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and pre-CEA were measured before nCRT, and post-CEA was measured before surgery. A total of 129 (73.3 %) good responders (TRG 3-4) and 47 (26.7 %) poor responders (TRG 0-2) were assessed after the nCRT. TC, LDL, HDL, and ΔCEA were 6.56 ± 0.95, 3.08 ± 0.72, and 1.43 ± 0.25 mmol/L and -0.69 ± 8.33 μg/mL in poor responders compared with 5.15 ± 1.29, 2.39 ± 0.5, and 1.37 ± 0.32 mmol/L and 16.67 ± 30.18 μg/mL in good responders, respectively (p < 0.05). TG, pre-CEA, and post-CEA were not significantly different. Multivariate logistic regression analysis revealed TC and ΔCEA as independent factors in predicting TRG; TC showed a sensitivity of 62.79 %, a specificity of 91.49 %, a Youden index of 0.543, a cutoff value of 5.52, and an AUC of 0.800 compared with ΔCEA (sensitivity 76.74 %, specificity 65.96 %, Youden index 0.427, and AUC 0.761). TC has a better predictive value than ΔCEA and hence might serve as a predictor of TRG in LARC patients.
authors.affiliation: Department of Radiation Oncology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, JiYan Road 440, Jinan, 250117, Shandong, China.
authors.forename: Chengxin
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, JiYan Road 440, Jinan, 250117, Shandong, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Medical Record Statistics, Shandong Jiaotong Hospital, Jinan, Shandong, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, JiYan Road 440, Jinan, 250117, Shandong, China.
authors.forename: Guanzhong
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, JiYan Road 440, Jinan, 250117, Shandong, China.
authors.forename: Xinkai
authors.initials: X
authors.lastname: Mo
authors.affiliation: Department of Plastic Surgery, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, JiYan Road 440, Jinan, 250117, Shandong, China. baoshli1963@163.com.
authors.forename: Baosheng
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, JiYan Road 440, Jinan, 250117, Shandong, China. yan880107@126.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yin
mesh_terms: D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000097:blood*; D059248:Chemoradiotherapy; D002784:Cholesterol / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood*
chemical_list: D002272:Carcinoembryonic Antigen; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Blood lipid parameters; Colorectal cancer; Neoadjuvant chemoradiotherapy; Prediction; Tumor regression grading