title: Coronary calcium scans and radiation exposure in the multi-ethnic study of atherosclerosis.
abstract: With the increasing use of coronary artery calcium (CAC) scoring to risk stratify asymptomatic patients for future cardiovascular events, there have been concerns raised regarding the theoretical risk of radiation exposure to this potentially large patient population. Newer CT protocols have sought to reduce radiation exposure without compromising image quality, but the reported radiation exposures in the literature remains widely variable (0.7-10.5 mSv). In this study, we report the radiation exposure of calcium scoring from our MESA cohort across several modern CT scanners with the aim of clarifying the radiation exposure of this imaging modality. To evaluate the mean effective doses of radiation, using dose length product, utilized for coronary artery calcium scoring in the MESA cohort, in an effort to understand estimated population quantity effective dose using individual measurements of scanner radiation output using current CT scanners. We reviewed effective dose in milliSieverts (mSv) for 3442 participants from the MESA cohort undergoing coronary artery calcium scoring, divided over six sites with four different modern CT scanners (Siemens64, Siemens Somatom Definition, GE64, and Toshiba 320). For effective dose calculation (milliSieverts, mSv), we multiplied the dose length product by conversion factor k (0.014). The mean effective dose amongst all participants was 1.05 mSv, a median dose of 0.95 mSV. The mean effective dose ranged from 0.74 to 1.26 across the six centers involved with the MESA cohort. The Siemens Somatom Definition scanner had effective dose of 0.53 (n = 123), Siemens 64 with 0.97 (n = 1684), GE 64 with 1.16 (n = 1219), and Toshiba 320 with 1.26 mSv (n = 416). Subgroup analysis by BMI, age, and gender showed no variability between scanners, gender, ages 45-74 years old, or BMI less than 30 kg/m(2). Subjects over age 75 yo had a mean effective dose of 1.29 ± 0.31 mSv, while the <75 yo subgroup was 0.78 ± 0.09 mSv (p < 0.05). Effective doses in subjects with BMI > 40 kg/m(2) was significantly greater than other subgroups, with mean dose of 1.47 ± 0.51 mSv (p < 0.01). Using contemporary CT scanners and protocols, the effective dose for coronary artery calcium is approximately 1 mSv, an estimate which is consistently lower than previously reported for CAC scanning, regardless of age, gender, and body mass index.
authors.affiliation: Los Angeles Biomedical Research Institute, 1124 W Carson Street, RB2, Torrance, CA, 90502, USA.
authors.forename: Bradley
authors.initials: B
authors.lastname: Messenger
authors.affiliation: Los Angeles Biomedical Research Institute, 1124 W Carson Street, RB2, Torrance, CA, 90502, USA.
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.affiliation: Los Angeles Biomedical Research Institute, 1124 W Carson Street, RB2, Torrance, CA, 90502, USA.
authors.forename: Khurram
authors.initials: K
authors.lastname: Nasir
authors.affiliation: Los Angeles Biomedical Research Institute, 1124 W Carson Street, RB2, Torrance, CA, 90502, USA.
authors.forename: J Jeffrey
authors.initials: JJ
authors.lastname: Carr
authors.affiliation: Los Angeles Biomedical Research Institute, 1124 W Carson Street, RB2, Torrance, CA, 90502, USA.
authors.forename: Ron
authors.initials: R
authors.lastname: Blankstein
authors.affiliation: Los Angeles Biomedical Research Institute, 1124 W Carson Street, RB2, Torrance, CA, 90502, USA. mbudoff@labiomed.org.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Budoff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography / Q000295:instrumentation / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000208:ethnology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D000069079:Radiation Exposure; D015898:Tomography Scanners, X-Ray Computed; D014057:Tomography, X-Ray Computed / Q000295:instrumentation; D014481:United States / Q000453:epidemiology; D061205:Vascular Calcification / Q000000981:diagnostic imaging* / Q000208:ethnology
keywords: Calcium scanning; Coronary artery calcium; Coronary artery disease; Radiation