title: Mesenchymal stem cells and chronic renal artery stenosis.
abstract: Renal artery stenosis is the main cause of renovascular hypertension and results in ischemic nephropathy characterized by inflammation, oxidative stress, microvascular loss, and fibrosis with consequent functional failure. Considering the limited number of strategies that effectively control renovascular hypertension and restore renal function, we propose that cell therapy may be a promising option based on the regenerative and immunosuppressive properties of stem cells. This review addresses the effects of mesenchymal stem cells (MSC) in an experimental animal model of renovascular hypertension known as 2 kidney-1 clip (2K-1C). Significant benefits of MSC treatment have been observed on blood pressure and renal structure of the stenotic kidney. The mechanisms involved are discussed.
authors.affiliation: Nephrology Division, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Oliveira-Sales
authors.affiliation: Nephrology Division, Federal University of São Paulo, São Paulo, Brazil maboim@unifesp.br.
authors.forename: Mirian A
authors.initials: MA
authors.lastname: Boim
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D006801:Humans; D006978:Hypertension, Renovascular / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007668:Kidney / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology / Q000378:metabolism; D019899:Paracrine Communication; D020127:Recovery of Function; D012038:Regeneration; D012078:Renal Artery Obstruction / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D015398:Signal Transduction
keywords: cell therapy; renal ischemia; renal sympathetic nerve; renin-angiotensin system; renovascular hypertension