title: Flavanones and Chromones from Salicornia herbacea Mitigate Septic Lethality via Restoration of Vascular Barrier Integrity.
abstract: Salicornia herbacea is an annual halophytic glasswort that has been employed as a culinary vegetable, salad, and traditional medicinal resource. Chemical investigation of the aerial parts of S. herbacea led to the isolation of two new (1, 2) and known (3) flavanones as well as a new nature-derived (4) and two known chromone derivatives (5, 6). These purified compounds were evaluated for their suppressive potentials against the release of high-mobility group box 1 protein (HMGB1), which has captured attention as a viable target for alleviating serious septic manifestations or septicemia. The phenolic compounds improved the survival rates of cecal ligation and puncture operation (CLP) in murine models, simulating severe septic shock and its related complications, to 40-60%. These results collectively validate that flavanone- and chromone-based secondary metabolites may serve as prospective prodrugs or food additives that may be commercialized for the control of septic complications and lethality.
authors.affiliation: College of Pharmacy, Chungnam National University , Daejeon 34134, Republic of Korea.|Phutho College of Pharmacy , Viettri City, Phutho Province, Vietnam.
authors.forename: Nguyen Quoc
authors.initials: NQ
authors.lastname: Tuan
authors.affiliation: College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University , Daegu 41566, Republic of Korea.|BK21 Plus KNU Biomedical Convergence Program, Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University , Daegu 41944, Republic of Korea.
authors.forename: Wonhwa
authors.initials: W
authors.lastname: Lee
authors.affiliation: Department of BioMolecular Sciences, Division of Pharmacognosy, and Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Joonseok
authors.initials: J
authors.lastname: Oh
authors.affiliation: College of Pharmacy, Chungnam National University , Daejeon 34134, Republic of Korea.
authors.forename: Roshan Rajan
authors.initials: RR
authors.lastname: Kulkarni
authors.affiliation: Department of BioMolecular Sciences, Division of Pharmacognosy, and Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Gény
authors.affiliation: College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University , Daegu 41566, Republic of Korea.
authors.forename: Byeongjin
authors.initials: B
authors.lastname: Jung
authors.affiliation: College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University , Daegu 41566, Republic of Korea.
authors.forename: Hyejin
authors.initials: H
authors.lastname: Kang
authors.affiliation: College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University , Daegu 41566, Republic of Korea.
authors.forename: Jong-Sup
authors.initials: JS
authors.lastname: Bae
authors.affiliation: College of Pharmacy, Chungnam National University , Daejeon 34134, Republic of Korea.
authors.forename: MinKyun
authors.initials: M
authors.lastname: Na
mesh_terms: D000818:Animals; D002432:Cecum / Q000601:surgery; D019663:Chenopodiaceae / Q000737:chemistry*; D002867:Chromones / Q000302:isolation & purification / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects*; D044950:Flavanones / Q000302:isolation & purification / Q000627:therapeutic use*; D024243:HMGB1 Protein / Q000037:antagonists & inhibitors / Q000502:physiology; D061307:Human Umbilical Vein Endothelial Cells; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry*; D018805:Sepsis / Q000188:drug therapy*; D012772:Shock, Septic / Q000188:drug therapy
chemical_list: D002867:Chromones; D044950:Flavanones; D024243:HMGB1 Protein; D008070:Lipopolysaccharides
keywords: Salicornia herbacea; chromones; flavanones; high mobility group box 1 protein; severe sepsis. endothelial barrier integrity