title: [Design, synthesis and biological evaluation of novel 3-(2-oxo-2-substituted acetamido)benzamides as PARP-1 inhibitors].
abstract: Poly(ADP-ribose)polymerase-1 (PARP-1) plays a significant role in the DNA repair process by catalyzing the transfer of ADP-ribose from NAD+ to its receptors. It is a promising anticancer drug target and many PARP-1 inhibitors have been developed and used in the clinical trial. In this work, a series of 3-(2-oxo-2-substituted acetamido)benzamides have been synthesized and their inhibitory activities against PARP-1 were evaluated. Of all the tested compounds, six compounds displayed inhibitory activities with IC50 values ranging from 0.23 to 5.78 µmol.L-1 . The binding pose of compound 5a was predicted using molecular docking to facilitate further structural modification.
authors.forename: Yu-wen
authors.initials: YW
authors.lastname: Yin
authors.forename: Ming
authors.initials: M
authors.lastname: Ji
authors.forename: Ran
authors.initials: R
authors.lastname: Cao
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Chen
authors.forename: Bai-ling
authors.initials: BL
authors.lastname: Xu
mesh_terms: D000970:Antineoplastic Agents; D001549:Benzamides / Q000737:chemistry*; D004260:DNA Repair; D015195:Drug Design; D006801:Humans; D062105:Molecular Docking Simulation; D000067856:Poly(ADP-ribose) Polymerase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D011065:Poly(ADP-ribose) Polymerases
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C037689:benzamide; D011065:Poly(ADP-ribose) Polymerases