title: Enantioselective Desymmetrization of Glutarimides Catalyzed by Oxazaborolidines Derived from cis-1-Amino-indan-2-ol.
abstract: Enantioselective reductive desymmetrization of glutarimides has been achieved employing an oxazaborolidine catalyst derived from cis-1-amino-indan-2-ol. The reaction was found to proceed through a stereoablative process that upgraded the enantioselectivity of an intermediate hydroxy-lactam. The reaction was generally tolerant of a number of substituents in the 4-position, giving enantiomeric excesses of greater than 82%.
authors.affiliation: Department of Chemistry, University of Sheffield , Dainton Building, Brook Hill, Sheffield, S3 7HF, U.K.
authors.forename: Ibrahim U
authors.initials: IU
authors.lastname: Kutama
authors.affiliation: Department of Chemistry, University of Sheffield , Dainton Building, Brook Hill, Sheffield, S3 7HF, U.K.
authors.forename: Simon
authors.initials: S
authors.lastname: Jones