title: The microRNA regulatory network: a far-reaching approach to the regulate the Wnt signaling pathway in number of diseases.
abstract: Wnt signaling pathway plays an important role in cell renewal, tumorigenesis, organogenesis, bone formation and bone resorption. Wnt signaling pathway is divided into two outlets: Wnt-β-catenin pathway (canonical pathway) and Wnt-calcium pathway (non-canonical pathway). miRNAs play a key role in the regulation of Wnt signaling pathway. In this review, we highlight the basic indulgent of miRNAs-mediated regulation of Wnt signaling pathway. We focus on the role of miRNAs at different levels of Wnt signaling: signaling molecules, their associated signaling proteins, regulatory proteins, transcription factors and related cytokines. Finally, we concluded that these multiple levels of targeting may have diagnostic potential as well as therapeutic prospective in future treatment.
authors.affiliation: a Immunogenetic Lab, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST) , Islamabad , Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Mahmood
authors.affiliation: a Immunogenetic Lab, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST) , Islamabad , Pakistan.
authors.forename: Attya
authors.initials: A
authors.lastname: Bhatti
authors.affiliation: a Immunogenetic Lab, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST) , Islamabad , Pakistan.
authors.forename: Nida Ali
authors.initials: NA
authors.lastname: Syed
authors.affiliation: a Immunogenetic Lab, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Science and Technology (NUST) , Islamabad , Pakistan.
authors.forename: Peter
authors.initials: P
authors.lastname: John
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004194:Disease / Q000235:genetics*; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000235:genetics*
chemical_list: D016207:Cytokines; D035683:MicroRNAs; D014157:Transcription Factors
keywords: MicroRNA; Wnt signaling pathway; signal transduction; therapeutics