title: A facile magnesium-containing calcium carbonate biomaterial as potential bone graft.
abstract: The calcium carbonate is the main composition of coral which has been widely used as bone graft in clinic. Herein, we readily prepared novel magnesium-containing calcium carbonate biomaterials (MCCs) under the low-temperature conditions based on the dissolution-recrystallization reaction between unstable amorphous calcium carbonate (ACC) and metastable vaterite-type calcium carbonate with water involved. The content of magnesium in MCCs was tailored by adjusting the proportion of ACC starting material that was prepared using magnesium as stabilizer. The phase composition of MCCs with various amounts of magnesium was composed of one, two or three kinds of calcium carbonates (calcite, aragonite, and/or magnesian calcite). The different MCCs differed in topography. The in vitro degradation of MCCs accelerated with increasing amount of introduced magnesium. The MCCs with a certain amount of magnesium not only acquired higher compressive strength, but also promoted in vitro cell proliferation and osteogenic differentiation. Taken together, the facile MCCs shed light on their potential as bone graft.
authors.affiliation: School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China; Department of Biomedical Engineering, School of Basic Sciences, Guangzhou Medical University, Guangzhou 510182, China. Electronic address: fphebm@126.com.
authors.forename: Fupo
authors.initials: F
authors.lastname: He
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Engineering, School of Basic Sciences, Guangzhou Medical University, Guangzhou 510182, China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Tian
authors.affiliation: School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China.
authors.forename: Shanghua
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, School of Basic Sciences, Guangzhou Medical University, Guangzhou 510182, China. Electronic address: xmchenw@126.com.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D016025:Bone Transplantation; D002119:Calcium Carbonate / Q000737:chemistry*; D002478:Cells, Cultured; D008274:Magnesium / Q000737:chemistry*; D051381:Rats; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D002119:Calcium Carbonate; D008274:Magnesium
keywords: Calcium carbonate; Cell behavior; Dissolution-recrystallization reaction; Magnesium; Topography