title: Hippocampal Remapping after Partial Inactivation of the Medial Entorhinal Cortex.
abstract: Hippocampal place cells undergo remapping when the environment is changed. The mechanism of hippocampal remapping remains elusive but spatially modulated cells in the medial entorhinal cortex (MEC) have been identified as a possible contributor. Using pharmacogenetic and optogenetic approaches, we tested the role of MEC cells by examining in mice whether partial inactivation in MEC shifts hippocampal activity to a different subset of place cells with different receptive fields. The pharmacologically selective designer Gi-protein-coupled muscarinic receptor hM4D or the light-responsive microbial proton pump archaerhodopsin (ArchT) was expressed in MEC, and place cells were recorded after application of the inert ligand clozapine-N-oxide (CNO) or light at appropriate wavelengths. CNO or light caused partial inactivation of the MEC. The inactivation was followed by substantial remapping in the hippocampus, without disruption of the spatial firing properties of individual neurons. The results point to MEC input as an element of the mechanism for remapping in place cells.
authors.affiliation: Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, Norwegian Brain Centre, 7489 Trondheim, Norway. Electronic address: chenglin.miao@ntnu.no.
authors.forename: Chenglin
authors.initials: C
authors.lastname: Miao
authors.affiliation: Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, Norwegian Brain Centre, 7489 Trondheim, Norway.
authors.forename: Qichen
authors.initials: Q
authors.lastname: Cao
authors.affiliation: Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, Norwegian Brain Centre, 7489 Trondheim, Norway.
authors.forename: Hiroshi T
authors.initials: HT
authors.lastname: Ito
authors.affiliation: Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, Norwegian Brain Centre, 7489 Trondheim, Norway.
authors.forename: Homare
authors.initials: H
authors.lastname: Yamahachi
authors.affiliation: Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, Norwegian Brain Centre, 7489 Trondheim, Norway.
authors.forename: Menno P
authors.initials: MP
authors.lastname: Witter
authors.affiliation: Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, Norwegian Brain Centre, 7489 Trondheim, Norway.
authors.forename: May-Britt
authors.initials: MB
authors.lastname: Moser
authors.affiliation: Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, Norwegian Brain Centre, 7489 Trondheim, Norway. Electronic address: edvard.moser@ntnu.no.
authors.forename: Edvard I
authors.initials: EI
authors.lastname: Moser
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004567:Electrodes, Implanted; D018728:Entorhinal Cortex / Q000166:cytology* / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology* / Q000502:physiology*; D008297:Male; D051379:Mice; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology