title: Prognostic value of (18)F-FDG PET/CT volumetric parameters in recurrent epithelial ovarian cancer.
abstract: OBJECTIVE
  Metabolic tumour volume (MTV) and total lesion glycolysis (TLG) from (18)F-FDG PET/CT are emerging prognostic biomarkers in various solid neoplasms. These volumetric parameters and the SUVmax have shown to be useful criteria for disease prognostication in preoperative and post-treatment epithelial ovarian cancer (EOC) patients. The purpose of this study was to evaluate the utility of (18)F-FDG PET/CT measurements to predict survival in patients with recurrent EOC.
  
  
  METHODS
  Twenty-six patients with EOC who underwent a total of 31 (18)F-FDG PET/CT studies for suspected recurrence were retrospectively included. SUVmax and volumetric parameters whole-body MTV (wbMTV) and whole-body TLG (wbTLG) with a threshold of 40% and 50% of the SUVmax were obtained. Correlation between PET parameters and progression-free survival (PFS) and the survival analysis of prognostic factors were calculated.
  
  
  RESULTS
  Serous cancer was the most common histological subtype (76.9%). The median PFS was 12.5 months (range 10.7-20.6 months). Volumetric parameters showed moderate inverse correlation with PFS but there was no significant correlation in the case of SUVmax. The correlation was stronger for first recurrences. By Kaplan-Meier analysis and log-rank test, wbMTV 40%, wbMTV 50% and wbTLG 50% correlated with PFS. However, SUVmax and wbTLG 40% were not statistically significant predictors for PFS.
  
  
  CONCLUSIONS
  Volumetric parameters wbMTV and wbTLG 50% measured by (18)F-FDG PET/CT appear to be useful prognostic predictors of outcome and may provide valuable information to individualize treatment strategies in patients with recurrent EOC.
authors.affiliation: Nuclear Medicine Department, Hospital Clínic, Barcelona, Spain. Electronic address: mmayoral@clinic.ub.es.
authors.forename: M
authors.initials: M
authors.lastname: Mayoral
authors.affiliation: Medical Oncology Department, Hospital Clínic, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fernandez-Martinez
authors.affiliation: Medical Oncology Department, Hospital Clínic, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Vidal
authors.affiliation: Nuclear Medicine Department, Hospital Clínic, Barcelona, Spain; Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Fuster
authors.affiliation: Medical Oncology Department, Hospital Clínic, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Aya
authors.affiliation: Nuclear Medicine Department, Hospital Clínic, Barcelona, Spain; Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Pavia
authors.affiliation: Nuclear Medicine Department, Hospital Clínic, Barcelona, Spain; Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Pons
authors.affiliation: Nuclear Medicine Department, Hospital Clínic, Barcelona, Spain; Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Lomeña
authors.affiliation: Nuclear Medicine Department, Hospital Clínic, Barcelona, Spain; Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Paredes
mesh_terms: D005260:Female; D006801:Humans; D064847:Multimodal Imaging; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
keywords: (18)F-FDG PET/CT; (18)F-FDG PET/TC; Cáncer epitelial de ovario recurrente; Glucólisis de lesión total; Intervalo libre de progresión; Metabolic tumour volume; Progression-free survival; Recurrent epithelial ovarian cancer; Total lesion glycolysis; Volumen tumoral metabólico