title: Metabolic Mechanisms of Drug Resistance in Leukemia.
abstract: Tumor cells frequently undergo metabolic reprogramming, but it is unknown how these metabolic changes relate to drug resistance. A recent article now demonstrates that PI3K/AKT signaling causes a metabolic switch from glutaminolysis to aerobic glycolysis in Notch-dependent T cell acute lymphoblastic leukemia (T-ALL).
authors.affiliation: Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Birgit
authors.initials: B
authors.lastname: Knoechel
authors.affiliation: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: jaster@partners.org.
authors.forename: Jon C
authors.initials: JC
authors.lastname: Aster
mesh_terms: D017209:Apoptosis / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006019:Glycolysis; D006801:Humans; D051058:Oncogene Protein v-akt / Q000235:genetics / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D051880:Receptors, Notch; D019869:Phosphatidylinositol 3-Kinases; D051058:Oncogene Protein v-akt