title: The Rationale and Timing of Molecular Genetic Testing for Dilated Cardiomyopathy.
abstract: The genetic evaluation of dilated cardiomyopathy (DCM) has been challenging, owing in large part to marked genetic heterogeneity. However, lower costs from next-generation sequencing have enabled gene discovery and the expansion of genetic testing panels. These advances have improved molecular diagnostics and predictive testing in DCM. We provide a rationale and recommendation for clinical genetic testing in all DCM cases.
authors.affiliation: Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA; Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio, USA.
authors.forename: Ana
authors.initials: A
authors.lastname: Morales
authors.affiliation: Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA; Cardiovascular Division, Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA; Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio, USA. Electronic address: ray.hershberger@osumc.edu.
authors.forename: Ray E
authors.initials: RE
authors.lastname: Hershberger
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D013997:Time Factors