title: Mitogen-Activated Protein Kinase Pathway: Genetic Analysis of 95 Adrenocortical Tumors.
abstract: Mitogen-activated protein kinase (MAPK) pathway is often deregulated in adrenocortical tumors (ACT) but with no concrete data confirming alteration rate. The objective of this study was to evaluate genetic alterations in key components of MAPK pathway. We found one BRAF mutation (p.V600E) and four HRAS silent mutations. No alteration was found in NRAS, KRAS, EGFR genes. The patient carrying BRAF mutation was further characterized by investigating his biomolecular and clinico-pathological findings. Therefore, even if MAPK signaling is activated in ACT, our results suggest that genetic alterations do not seem to represent a frequent mechanism of ACT tumorigenesis.
authors.affiliation: a Division of Endocrinology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Rubin
authors.affiliation: a Division of Endocrinology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Halenya
authors.initials: H
authors.lastname: Monticelli
authors.affiliation: b Department of Molecular Medicine , University of Padua , Padua , Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Redaelli
authors.affiliation: b Department of Molecular Medicine , University of Padua , Padua , Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Mucignat
authors.affiliation: a Division of Endocrinology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Susi
authors.initials: S
authors.lastname: Barollo
authors.affiliation: a Division of Endocrinology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Loris
authors.initials: L
authors.lastname: Bertazza
authors.affiliation: a Division of Endocrinology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Mian
authors.affiliation: a Division of Endocrinology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Betterle
authors.affiliation: c Division of Minimally Invasive Endocrine Surgery, Department of Surgery, Oncology and Gastroenterology , University of Padua , Padua , Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Iacobone
authors.affiliation: d Division of Pathology and Cytopathology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Ambrogio
authors.initials: A
authors.lastname: Fassina
authors.affiliation: a Division of Endocrinology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Boscaro
authors.affiliation: a Division of Endocrinology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pezzani
authors.affiliation: a Division of Endocrinology, Department of Medicine (DIMED) , University of Padua , Padua , Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Mantero
mesh_terms: D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics*; D055815:Young Adult
chemical_list: D019950:Mitogen-Activated Protein Kinase 1
keywords: Adrenocortical carcinomas; Adrenocortical tumors; BRAF; MAPK signaling pathway; RAS