title: Treatment of Pancreatic Adenocarcinoma in Elderly Patients over 75 Years of Age: A Retrospective Series of 129 Patients.
abstract: OBJECTIVE
  To better know the presentation and outcome of pancreatic adenocarcinoma in patients above 75 years of age.
  
  
  METHODS
  Retrospective analysis of consecutive patients with a pancreatic adenocarcinoma seen in the Comprehensive Cancer Center of Marseille between January 2002 and January 2012 was used.
  
  
  RESULTS
  During these 10 years, 129 patients older than 75 years of age were seen, 61 females and 68 males, median age 78. At diagnosis, the tumor was metastatic in 45%. First line treatments were: surgical resection in 22 cases, radio-chemotherapy in 20 cases (1 operated on later), systemic chemotherapy in 59 cases, and best supportive care alone in 28 cases. Resection was possible in 19 cases and was R0 in 17; post-operative mortality was 0%, and half received adjuvant chemotherapy. Median overall survival was 43 months with a 2-year overall survival of 64%. For locally advanced tumor, 16 received best supportive care and 33 a specific treatment (20 cases of radio-chemotherapy). Median overall survival was 9.1 months and 2-year overall, survival was 6.1%. Among the 58 metastatic patients, 79% received systemic chemotherapy (most by gemcitabine); tolerance was correct in half. Median overall survival was 4.7 months, with a 2-year overall survival of 5.3%.
  
  
  CONCLUSIONS
  Surgery of pancreatic adenocarcinoma is feasible and safe in elderly patients with good outcomes. In advanced and metastatic patients, the outcome is poor despite a correct tolerance of systemic chemotherapy. Randomized trials specially designed for this population are urgently needed.
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, BP 156, 13273, Marseille, France. oziels@ipc.unicancer.fr.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Oziel-Taieb
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, BP 156, 13273, Marseille, France. faurem@ipc.unicancer.fr.
authors.forename: Marjorie
authors.initials: M
authors.lastname: Faure
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, BP 156, 13273, Marseille, France. gilabertm@ipc.unicancer.fr.
authors.forename: Marine
authors.initials: M
authors.lastname: Gilabert
authors.affiliation: Statistical Unit, Paoli-Calmettes Institute, BP 156, 13273, Marseille, France. autreta@ipc.unicancer.fr.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Autret
authors.affiliation: Department of Surgical Oncology, Paoli-Calmettes Institute, BP 156, 13273, Marseille, France. turrinio@ipc.unicancer.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Turrini
authors.affiliation: Department of Radiotherapy, Paoli-Calmettes Institute, BP 156, 13273, Marseille, France. moureaul@ipc.unicancer.fr.
authors.forename: Laurence
authors.initials: L
authors.lastname: Moureau-Zabotto
authors.affiliation: Department of Interventional Endoscopy, Paoli-Calmettes Institute, BP 156, 13273, Marseille, France. giovanninim@ipc.unicancer.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Giovannini
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, BP 156, 13273, Marseille, France. rousseauf@ipc.unicancer.fr.
authors.forename: Frederique
authors.initials: F
authors.lastname: Rousseau
authors.affiliation: Department of Medical Oncology, Paoli-Calmettes Institute, BP 156, 13273, Marseille, France. raouljl@ipc.unicancer.fr.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Raoul
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary / Q000628:therapy*; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000556:secondary / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Elderly; Gemcitabine; Pancreatic adenocarcinoma; Resection; Systemic chemotherapy