title: Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments.
abstract: Recent clinical studies indicate a strong link between AKI and progression of CKD. The increasing prevalence of AKI must compel the nephrology community to consider the long-term ramifications of this syndrome. Considerable gaps in knowledge exist regarding the connection between AKI and CKD. The 13th Acute Dialysis Quality Initiative meeting entitled "Therapeutic Targets of Human Acute Kidney Injury: Harmonizing Human and Experimental Animal Acute Kidney Injury" convened in April of 2014 and assigned a working group to focus on issues related to progression after AKI. This article provides a summary of the key conclusions and recommendations of the group, including an emphasis on terminology related to injury and repair processes for both clinical and preclinical studies, elucidation of pathophysiologic alterations of AKI, identification of potential treatment strategies, identification of patients predisposed to progression, and potential management strategies.
authors.affiliation: Department of Cellular and Integrative Physiology and Department of Medicine, Division of Nephrology, Indiana University, Indianapolis, Indiana; dpbasile@iupui.edu.
authors.forename: David P
authors.initials: DP
authors.lastname: Basile
authors.affiliation: Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;
authors.forename: Joseph V
authors.initials: JV
authors.lastname: Bonventre
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, California;
authors.forename: Ravindra
authors.initials: R
authors.lastname: Mehta
authors.affiliation: Division of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan;
authors.forename: Masaomi
authors.initials: M
authors.lastname: Nangaku
authors.affiliation: Division of Medicine, University College London Centre for Nephrology, University College London, London, United Kingdom;
authors.forename: Robert
authors.initials: R
authors.lastname: Unwin
authors.affiliation: Department of Medicine, Nephrology Division and the Centre for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, Virginia;
authors.forename: Mitchell H
authors.initials: MH
authors.lastname: Rosner
authors.affiliation: Center for Critical Care Nephrology, The Clinical Research, Investigation, and Systems Modeling of Acute Illness Centre, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and.
authors.forename: John A
authors.initials: JA
authors.lastname: Kellum
authors.affiliation: Department of Nephrology Dialysis and Transplantation, San Bortolo Hospital and the International Renal Research Institute, Vicenza, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000473:pathology / Q000628:therapy; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D059447:Cell Cycle Checkpoints; D004260:DNA Repair; D018450:Disease Progression; D005355:Fibrosis; D006801:Humans; D000860:Hypoxia / Q000150:complications; D007668:Kidney / Q000473:pathology*; D008928:Mitochondria / Q000502:physiology; D018384:Oxidative Stress; D051436:Renal Insufficiency, Chronic / Q000209:etiology* / Q000628:therapy; D009626:Terminology as Topic
chemical_list: D015415:Biomarkers
keywords: acute renal failure; chronic renal; disease; fibrosis; progression of renal failure