title: Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest.
abstract: Cytokines are well known mediators of numerous physiological and pathological processes. They contribute to the regulation of normal hematopoiesis but increasing data suggest that they also have a clinical impact in some hematopoietic malignancies. In particular, there is evidence that cytokines are implicated in the functional symptoms of Philadelphia negative myeloproliferative neoplasms (Ph- MPNs), suggesting that evaluation of circulating levels of cytokines could be of clinical interest for the characterization of patients at the time of diagnosis and for disease prognosis. In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. Phenotypic correlation, prognostic value of cytokines, and impact of JAK inhibitors are also discussed.
authors.affiliation: UF de Pathologie Moléculaire, Département d'Anatomie et Cytologie Pathologiques, CHU Grenoble, 38043 Grenoble Cedex 09, France ; Equipe TheRex Laboratoire TIMC-IMAG-UMR5525 CNRS, Université Grenoble Alpes, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Mondet
authors.affiliation: Institute of Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
authors.forename: Kais
authors.initials: K
authors.lastname: Hussein
authors.affiliation: Equipe TheRex Laboratoire TIMC-IMAG-UMR5525 CNRS, Université Grenoble Alpes, France ; Laboratoire d'Hématologie Cellulaire, Institut de Biologie et Pathologie, CHU Grenoble, 38043 Grenoble Cedex 09, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Mossuz
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D018450:Disease Progression; D005786:Gene Expression Regulation; D006098:Granulocytes / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood*; D053612:Janus Kinases / Q000037:antagonists & inhibitors; D009196:Myeloproliferative Disorders / Q000097:blood* / Q000175:diagnosis; D010641:Phenotype; D010677:Philadelphia Chromosome; D055728:Primary Myelofibrosis / Q000097:blood* / Q000175:diagnosis; D011379:Prognosis
chemical_list: D015415:Biomarkers; D016207:Cytokines; D053612:Janus Kinases