title: Characteristics of Resting Metabolic Rate in Critically Ill, Mechanically Ventilated Adults With Cystic Fibrosis.
abstract: Critically ill patients with cystic fibrosis may be especially sensitive to the negative consequences of overfeeding and underfeeding, yet there is almost no information available about the energy needs of these patients. The purpose of this study was to characterize the metabolic rate of critically ill adult patients with cystic fibrosis requiring mechanical ventilation.
  
  
  
  This was an observational study in which the resting metabolic rate, oxygen consumption, and carbon dioxide production of adult patients with cystic fibrosis requiring critical care, sedation, and mechanical ventilation were measured with indirect calorimetry. This group was compared with a cohort of adult critical care patients without cystic fibrosis.
  
  
  
  Twelve patients with cystic fibrosis were identified and measured. These were compared with a control group of 25 critically ill patients. Both groups were underweight (body mass index, 17.4 ± 4.0 kg/m2in cystic fibrosis and 18.4 ± 2.3 kg/m2in control). Adjusting for differences in age, sex, height, and weight, there was no difference in resting metabolic rate between the cystic fibrosis and control groups (1702 ± 193 vs 1642 ± 194 kcal/d, P = .388). Measured resting metabolic rate matched predicted values 58% of the time in cystic fibrosis and 60% of the time in control.
  
  
  
  The resting metabolic rate of sedated adult patients with cystic fibrosis being assisted with mechanical ventilation is not different from that of adult critical care patients without cystic fibrosis. In both these underweight groups, accurate prediction of resting metabolic rate is difficult to obtain.
authors.affiliation: 1 Department of Clinical Nutrition, Department of Nursing, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: David C
authors.initials: DC
authors.lastname: Frankenfield
authors.affiliation: 1 Department of Clinical Nutrition, Department of Nursing, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Ashcraft
authors.affiliation: 1 Department of Clinical Nutrition, Department of Nursing, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Tammy L
authors.initials: TL
authors.lastname: Drasher
authors.affiliation: 1 Department of Clinical Nutrition, Department of Nursing, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Reid
authors.affiliation: 2 Department of Pulmonary Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Vender
mesh_terms: D000328:Adult; D001481:Basal Metabolism; D015992:Body Mass Index; D001835:Body Weight; D002153:Calorimetry, Indirect; D002245:Carbon Dioxide / Q000378:metabolism; D016022:Case-Control Studies; D003422:Critical Care; D016638:Critical Illness; D003550:Cystic Fibrosis / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D012121:Respiration, Artificial; D013851:Thinness / Q000628:therapy; D055815:Young Adult
chemical_list: D002245:Carbon Dioxide
keywords: cystic fibrosis; energy expenditure