title: Anti-Inflammatory Activity Comparison among Scropoliosides-Catalpol Derivatives with 6-O-Substituted Cinnamyl Moieties.
abstract: We have previously shown that scropolioside B has higher anti-inflammatory activity than catalpol does after the inhibition of nuclear factor (NF)-κB activity and IL-1β expression, maturation, and secretion. Various scropoliosides were extracted, isolated, and purified from Scrophularia dentata Royle ex Benth. We then compared their anti-inflammatory activities against LPS-induced NF-κB activity, cytokines mRNA expression, IL-1β secretion, and cyclooxygenase-2 activity. The inhibitory effects of the scropoliosides varied depending on whether the 6-O-substituted cinnamyl moiety was linked to C'' 2-OH, C''3-OH, or C''4-OH, and on the number of moieties linked, which is closely related to the enhancement of antiinflammatory activity. Among these compounds, scropolioside B had the strongest antiinflammatory effects.
authors.affiliation: Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine. 04100217@163.com.|School of Pharmacy, Shanghai University of Traditional Chinese Medicine. 04100217@163.com.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Zhu
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine. 04100217@163.com.
authors.forename: Liuqiang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine. sarah_ling@126.com.
authors.forename: Shuang
authors.initials: S
authors.lastname: Ling
authors.affiliation: Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine. 04100217@163.com.|School of Pharmacy, Shanghai University of Traditional Chinese Medicine. 04100217@163.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Qian
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine. ymlius@163.com.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.affiliation: Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine. jinwen.xu88@gmail.com.
authors.forename: Jin-Wen
authors.initials: JW
authors.lastname: Xu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D015870:Gene Expression; D057809:HEK293 Cells; D006801:Humans; D057888:Iridoid Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D016328:NF-kappa B / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D057888:Iridoid Glucosides; D016328:NF-kappa B; D010936:Plant Extracts; C078040:catalpol; D016718:Arachidonic Acid
keywords: 6-O-substituted cinnamyl moiety; NF-κB; antiinflammatory effect; cytokines; scropoliosides