title: Golimumab for the treatment of axial spondyloarthritis.
abstract: Axial spondyloarthritis (axSpA) is a chronic, immune-mediated inflammatory disease of the axial skeleton that includes ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Patients with AS experience chronic pain due to sacroiliac joint and spinal inflammation, and may develop spinal ankylosing with syndesmophyte formation. Tumor necrosis factor α inhibitors (TNFi) have shown promise in the management of AS and axSpA by targeting the underlying inflammatory process, and providing symptomatic relief. Whether they alter the progression of the disease is uncertain. Golimumab is a fully human IgG1 monoclonal antibody that targets and downregulates the pro-inflammatory cytokine TNF-α. The use of golimumab has been shown to reduce the signs and symptoms of axSpA as well as improve patient function and quality reported outcomes. This review focuses on the biological rationale and the results of clinical trials with golimumab for the treatment of axSpA.
authors.affiliation: a Division of Arthritis & Rheumatic Diseases (OP09) , Oregon Health & Science University , Portland , OR 97239 , USA.
authors.forename: Gita
authors.initials: G
authors.lastname: Gelfer
authors.affiliation: a Division of Arthritis & Rheumatic Diseases (OP09) , Oregon Health & Science University , Portland , OR 97239 , USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Perry
authors.affiliation: a Division of Arthritis & Rheumatic Diseases (OP09) , Oregon Health & Science University , Portland , OR 97239 , USA.
authors.forename: Atul
authors.initials: A
authors.lastname: Deodhar
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007167:Immunotherapy; D013167:Spondylitis, Ankylosing / Q000276:immunology / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; C529000:golimumab
keywords: Ankylosing spondylitis; TNF inhibitors; anti-tumor necrosis factor; axial spondyloarthritis; golimumab; non-radiographic axial spondyloarthritis