title: Visualized intravesical floating hydrogel encapsulating vaporized perfluoropentane for controlled drug release.
abstract: Intravesical drug delivery is the main strategy for the treatment of bladder disorders. To reduce the relief arising from frequent intravesical instillation, mucoadhesive hydrogel was used for the controlled release of the drug. However, the viscosity of mucoadhesive gel might cause severe urinary obstruction and bladder irritation. To solve all these problems, a floating hydrogel delivery system was developed using perfluoropentane (PFP) as the floating agent. After intravesical instillation of the floating hydrogel, the increased temperature in bladder vaporized PFP, resulting in the generation of microbubbles in the hydrogel. Then, it can float in urine to avoid the urinary obstruction and bladder irritation. In this study, systematic experiments were conducted to investigate the influences of PFP vaporization on the morphology and floating ability of hydrogels. The floating process is much milder and safer than other floating methods published before. In addition, PFP had been used as contrast agent, which affiliated the monitoring of gels during the operation. Therefore, this new drug delivery system addresses the problems of conventional intravesical instillation and is promising for clinic use.
authors.affiliation: a Department of Urology , Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School , Nanjing , China and.|b State Key Laboratory of Pharmaceutical Biotechnolgy, Medical School, Nanjing University , Nanjing , China.
authors.forename: Guanchen
authors.initials: G
authors.lastname: Zhu
authors.affiliation: b State Key Laboratory of Pharmaceutical Biotechnolgy, Medical School, Nanjing University , Nanjing , China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: b State Key Laboratory of Pharmaceutical Biotechnolgy, Medical School, Nanjing University , Nanjing , China.
authors.forename: Kaikai
authors.initials: K
authors.lastname: Wang
authors.affiliation: a Department of Urology , Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School , Nanjing , China and.
authors.forename: Xiaozhi
authors.initials: X
authors.lastname: Zhao
authors.affiliation: a Department of Urology , Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School , Nanjing , China and.
authors.forename: Huibo
authors.initials: H
authors.lastname: Lian
authors.affiliation: a Department of Urology , Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School , Nanjing , China and.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: b State Key Laboratory of Pharmaceutical Biotechnolgy, Medical School, Nanjing University , Nanjing , China.
authors.forename: Haoran
authors.initials: H
authors.lastname: Wang
authors.affiliation: a Department of Urology , Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School , Nanjing , China and.|b State Key Laboratory of Pharmaceutical Biotechnolgy, Medical School, Nanjing University , Nanjing , China.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wu
authors.affiliation: a Department of Urology , Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School , Nanjing , China and.|b State Key Laboratory of Pharmaceutical Biotechnolgy, Medical School, Nanjing University , Nanjing , China.
authors.forename: Yiqiao
authors.initials: Y
authors.lastname: Hu
authors.affiliation: a Department of Urology , Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School , Nanjing , China and.
authors.forename: Hongqian
authors.initials: H
authors.lastname: Guo
mesh_terms: D000283:Administration, Intravesical; D000818:Animals; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D005466:Fluorocarbons / Q000008:administration & dosage / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage / Q000737:chemistry*; D008297:Male; D009330:Nebulizers and Vaporizers; D011817:Rabbits; D013696:Temperature; D001743:Urinary Bladder / Q000378:metabolism; D014783:Viscosity; D010420:Pentanes
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005466:Fluorocarbons; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C008806:perfluoropentane; D010420:Pentanes
keywords: Bladder disorders; floating hydrogel; intravesical instillation; perfluoropentane; thermo-sensitive hydrogel