title: Present and Future of Regenerative Medicine: Liver Transplantation.
abstract: In recent years, the creation of new organs using bioengineering has been proposed as a possible solution to the shortage of organs for transplantation. After decellularization of livers, the remaining extracellular matrix can be used as scaffolds that can be reseeded with different kinds of cells. Mature hepatocytes and fetal liver cells have been used, showing viability, functionality, and differentiation into mature cells. After perfusion in a bioreactor, the seeded scaffold or liver organoid may be transplanted. However, viability of these transplanted scaffolds is poor owing to the formation of thrombosis. We analyzed the recent advances in decellularizing and recellularizing and the results after transplantation reported in the literature.
authors.affiliation: Servei Cirurgia Hepatobiliopancreàtica i Trasplants, Hospital Universitari Vall Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: mcaralt@vhebron.net.
authors.forename: M
authors.initials: M
authors.lastname: Caralt
mesh_terms: D057005:Bioengineering; D019149:Bioreactors; D002454:Cell Differentiation; D005109:Extracellular Matrix; D022781:Hepatocytes / Q000637:transplantation*; D006801:Humans; D008099:Liver; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation; D010477:Perfusion; D044968:Regenerative Medicine; D054457:Tissue Scaffolds; D019737:Transplants