title: A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm.
abstract: The preparation of triazamacrocyclic hydroxypyridinonate (HOPO-TACN) derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2'-(1,4,7-triazonane-1,4-diyl) diacetate was coupled with a hydroxypyridinonate pendant arm. The method is suitable for rapid syntheses of metal chelator HOPO-TACNs of biomedical interest.
authors.affiliation: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. gykmail@gmail.com.
authors.forename: Yongkang
authors.initials: Y
authors.lastname: Gai
authors.affiliation: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. maxwellsg@163.com.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Hu
authors.affiliation: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. wojiaorz@gmail.com.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Rong
authors.affiliation: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. xiangma@hust.edu.cn.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.affiliation: School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. youjiti@mails.tjmu.edu.cn.
authors.forename: Guangya
authors.initials: G
authors.lastname: Xiang
mesh_terms: D002614:Chelating Agents / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis*; D014226:Triazenes / Q000138:chemical synthesis*; D014227:Triazines / Q000138:chemical synthesis*
chemical_list: C000609750:2,2-(7-(2-(3-hydroxy-2-oxopyridin-1(2H)-yl)ethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid; C000609751:2,2-(7-(3-(3-hydroxy-2-oxopyridin-1(2H)-yl)propyl)-1,4,7-triazonane-1,4-diyl)diacetic acid; D002614:Chelating Agents; D011725:Pyridines; D014226:Triazenes; D014227:Triazines
keywords: 1,4,7-triazonane; hydroxypyridinonate; metal chelator