title: Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy.
abstract: A pertussis vaccination during pregnancy has recently been adopted in several countries to indirectly protect young infants. This study assessed the effect of adding a pertussis component to the tetanus vaccination, in the pregnancy immunization program in Vietnam. A randomized controlled trial was performed. Pregnant women received either a Tdap (tetanus, diphtheria acellular pertussis) vaccine or a tetanus only vaccine between 19 and 35 weeks' gestational age. Immunoglobulin G (IgG) against tetanus (TT), diphtheria (DT), pertussis toxin (PT), filamentous hemaglutinin (FHA) and pertactin (Prn) were measured using commercial ELISA tests, at baseline, 1 month after maternal vaccination, at delivery, and in infants from cord blood and before and after the primary series (EPI: month 2-3-4) of a pertussis containing vaccine. Significantly higher geometric mean concentrations (GMC) were observed for all 3 measured pertussis antigens in the offspring of the Tdap group, up to 2 months of age. One month after completion of the primary infant vaccination schedule, anti-Prn GMC, but not anti-PT and anti-FHA GMCs, was significantly (p=0.006) higher in the control group. Maternal antibodies induced by vaccination during pregnancy close the susceptibility gap for pertussis in young infants. Limited interference with the infant vaccine responses was observed. Whether this interference effect disappears with the administration of a fourth vaccine dose is further studied.
authors.affiliation: National Institute of Hygiene and Epidemiology, Yersin Street 1, Hanoi 10000, Vietnam. Electronic address: hoangha.nihe@gmail.com.
authors.forename: Ha Thi Thu
authors.initials: HT
authors.lastname: Hoang
authors.affiliation: Centre for the Evaluation of Vaccination, Vaccine and Infectious Diseases Institute, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610 Antwerpen, Belgium.
authors.forename: Elke
authors.initials: E
authors.lastname: Leuridan
authors.affiliation: Centre for the Evaluation of Vaccination, Vaccine and Infectious Diseases Institute, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610 Antwerpen, Belgium.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Maertens
authors.affiliation: National Institute of Hygiene and Epidemiology, Yersin Street 1, Hanoi 10000, Vietnam.
authors.forename: Trung Dac
authors.initials: TD
authors.lastname: Nguyen
authors.affiliation: Interuniversity Institute for Biostatistics and Statistical Bioinformatics (I-BIOSTAT), Hasselt University, Hasselt, Belguim; Centre for Health Economics Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerpen, Belgium.
authors.forename: Niel
authors.initials: N
authors.lastname: Hens
authors.affiliation: School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.
authors.forename: Ngoc Ha
authors.initials: NH
authors.lastname: Vu
authors.affiliation: National Reference Centre Bordetella, Service Immunology, Scientific Institute of Public Health (WIV-ISP), 1180 Brussels, Belgium.
authors.forename: Raissa Nadège
authors.initials: RN
authors.lastname: Caboré
authors.affiliation: National Institute of Hygiene and Epidemiology, Yersin Street 1, Hanoi 10000, Vietnam.
authors.forename: Hong Thi
authors.initials: HT
authors.lastname: Duong
authors.affiliation: National Reference Centre Bordetella, Service Immunology, Scientific Institute of Public Health (WIV-ISP), 1180 Brussels, Belgium.
authors.forename: Kris
authors.initials: K
authors.lastname: Huygen
authors.affiliation: Centre for the Evaluation of Vaccination, Vaccine and Infectious Diseases Institute, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610 Antwerpen, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Van Damme
authors.affiliation: National Institute of Hygiene and Epidemiology, Yersin Street 1, Hanoi 10000, Vietnam. Electronic address: ducanh@nihe.org.vn.
authors.forename: Anh Duc
authors.initials: AD
authors.lastname: Dang
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage*; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007115:Immunization Schedule; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D016896:Treatment Outcome; D014744:Vietnam; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines
keywords: Maternal antibodies; Pertussis; Pregnancy; Vaccination