title: Regulation of CD8+ T-cell cytotoxicity in HIV-1 infection.
abstract: Understanding the mechanisms involved in cellular immune responses against control of human immunodeficiency virus (HIV) infection is key to development of effective immunotherapeutic strategies against viral proliferation. Clear insights into the regulation of cytotoxic CD8+ T cells is crucial to development of effective immunotherapeutic strategies due to their unique ability to eliminate virus-infected cells during the course of infection. Here, we reviewed the roles of transcription factors, co-inhibitory molecules and regulatory cytokines following HIV infection and their potential significance in regulating the cytotoxic potentials of CD8+ T cells.
authors.affiliation: Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia.
authors.forename: Alireza
authors.initials: A
authors.lastname: Saeidi
authors.affiliation: Department of Microbiology, University of Pennsylvania, USA.
authors.forename: Marcus
authors.initials: M
authors.lastname: Buggert
authors.affiliation: Institute for Environmental Medicine, Karolinska Institute, Solna, 17 177 Stockholm, Sweden.
authors.forename: Karlhans F
authors.initials: KF
authors.lastname: Che
authors.affiliation: Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia.
authors.forename: Yong Y
authors.initials: YY
authors.lastname: Kong
authors.affiliation: Department of Microbiology and Immunology, Emory University, GA, Atlanta, USA.
authors.forename: Vijayakumar
authors.initials: V
authors.lastname: Velu
authors.affiliation: Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
authors.forename: Marie
authors.initials: M
authors.lastname: Larsson
authors.affiliation: Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia; Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia. Electronic address: shankarem@um.edu.my.
authors.forename: Esaki M
authors.initials: EM
authors.lastname: Shankar
mesh_terms: D016207:Cytokines / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D053804:Granzymes / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D054353:Perforin / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014157:Transcription Factors / Q000276:immunology
chemical_list: D016207:Cytokines; D014157:Transcription Factors; D054353:Perforin; D053804:Granzymes
keywords: CD8+ T cells; Cytokines; Cytotoxicity; HIV; Perforin; Transcription factors