title: Body composition is more closely related to the development of knee osteoarthritis in women than men: a cross-sectional study using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1, 2).
abstract: OBJECTIVE
  To evaluate the association between knee osteoarthritis (OA) and body composition parameters, and to analyze the correlations of both obesity and lower extremity muscle mass with radiographic knee OA in relation to sex.
  
  
  METHODS
  This was a cross-sectional study using data on body composition parameters measured using dual energy X-ray absorptiometry in 4246 participants in the Fifth Korea National Health and Nutrition Examination Survey. The relationships between knee OA and body composition parameters were evaluated. The associations between knee OA and the four subgroups corresponding to obesity and muscle mass percentage in both lower extremities were analyzed separately for each sex.
  
  
  RESULTS
  The lower extremity muscle mass showed a decreasing trend, while fat parameters showed an increasing linear trend (P for trend <0.05) with increasing severity of knee OA in women. The odds ratio of each quarter percentile group (25 percentile) for fat parameters showed an increasing trend, while that of the lower extremity muscle mass showed a decreasing linear trend in relation to knee OA in women (P for trend < 0.05). In women, low percentage of lower extremity muscle mass was more associated with knee OA regardless of obesity (P < 0.05). However, there were no associations between all body composition parameters and knee OA in men.
  
  
  CONCLUSIONS
  In women, high fat mass and low lower extremity muscle mass were associated with presence and severity of knee OA. Lower extremity muscle mass was more closely correlated with knee OA than obesity in women.
authors.affiliation: Department of Orthopedic Surgery, Korea University College of Medicine, Ansan Hospital, Gyeounggi-do, South Korea.
authors.forename: D H
authors.initials: DH
authors.lastname: Suh
authors.affiliation: Department of Medical Statistics, Catholic University College of Medicine, Seoul, South Korea.
authors.forename: K D
authors.initials: KD
authors.lastname: Han
authors.affiliation: Department of Orthopedic Surgery, Korea University College of Medicine, Ansan Hospital, Gyeounggi-do, South Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Hong
authors.affiliation: Department of Orthopedic Surgery, Korea University College of Medicine, Ansan Hospital, Gyeounggi-do, South Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Orthopedic Surgery, Korea University College of Medicine, Guro Hospital, Seoul, South Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Bae
authors.affiliation: Department of Orthopedic Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.
authors.forename: Y W
authors.initials: YW
authors.lastname: Moon
authors.affiliation: Department of Orthopedic Surgery, Korea University College of Medicine, Ansan Hospital, Gyeounggi-do, South Korea. Electronic address: jgkim7437@gmail.com.
authors.forename: J G
authors.initials: JG
authors.lastname: Kim
mesh_terms: D000368:Aged; D000886:Anthropometry / Q000379:methods; D001823:Body Composition / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D009749:Nutrition Surveys; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D009929:Organ Size / Q000502:physiology; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D011859:Radiography; D056910:Republic of Korea / Q000453:epidemiology; D012720:Severity of Illness Index; D012737:Sex Factors
keywords: Body composition; Knee; Osteoarthritis; Sex