title: Rinsing with antacid suspension reduces hydrochloric acid-induced erosion.
abstract: OBJECTIVE
  Mouthrinsing with antacids, following erosive episodes, have been suggested as a preventative strategy to minimize tooth surface loss due to their neutralizing effect. The purpose of this in situ study was to evaluate the effect of an antacid suspension containing sodium alginate, sodium bicarbonate and calcium carbonate in controlling simulated erosion of enamel of intrinsic origin.
  
  
  METHODS
  The experimental units were 48 slabs (3×3×2mm) of bovine enamel, randomly divided among 12 volunteers who wore palatal appliances with two enamel slabs. One of them was exposed extra-orally twice a day to 25mL of a hydrochloric acid (HCl) solution (0.01M, pH 2) for 2min. There were two independent phases, lasting 5 days each. In the first phase, according to a random scheme, half of the participants rinsed with 10mL of antacid suspension (Gaviscon(®), Reckitt Benckiser Healthcare Ltd.), while the remainder was rinsed with deionized water, for 1min. For the second phase, new slabs were inserted and participants switched to the treatment not received in the first stage. Therefore, the groups were as follows: (a) erosive challenge with HCl+antacid suspension; (b) erosive challenge with HCl+deionized water (DIW); (c) no erosive challenge+antacid suspension; (d) no erosive challenge+DIW. Specimens were assessed in terms of surface loss using optical profilometry and Knoop microhardness. The data were analyzed using repeated measures two-way analysis of variance and Tukey's tests.
  
  
  RESULTS
  Compared to DIW rinses, surface loss of enamel was significantly lower when using an antacid rinse following erosive challenges (p=0.015). The Knoop microhardness of the enamel was significantly higher when the antacid rinse was used (p=0.026).
  
  
  CONCLUSIONS
  The antacid suspension containing sodium alginate, sodium bicarbonate and calcium carbonate, rinsed after erosive challenges of intrinsic origin, reduced enamel surface loss.
authors.affiliation: Division of Cariology and Restorative Dentistry, São Leopoldo Mandic Institute and Dental Research Center, R. Dr José Rocha Junqueira 13, Campinas, SP 13045-755, Brazil.
authors.forename: Maria do Socorro Coelho
authors.initials: Mdo S
authors.lastname: Alves
authors.affiliation: Department of Restorative Dentistry, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes 2227, São Paulo, SP 05508-000, Brazil.
authors.forename: Taís Fonseca
authors.initials: TF
authors.lastname: Mantilla
authors.affiliation: Division of Cariology and Restorative Dentistry, São Leopoldo Mandic Institute and Dental Research Center, R. Dr José Rocha Junqueira 13, Campinas, SP 13045-755, Brazil.
authors.forename: Enrico Coser
authors.initials: EC
authors.lastname: Bridi
authors.affiliation: Division of Cariology and Restorative Dentistry, São Leopoldo Mandic Institute and Dental Research Center, R. Dr José Rocha Junqueira 13, Campinas, SP 13045-755, Brazil.
authors.forename: Roberta Tarkany
authors.initials: RT
authors.lastname: Basting
authors.affiliation: Division of Cariology and Restorative Dentistry, São Leopoldo Mandic Institute and Dental Research Center, R. Dr José Rocha Junqueira 13, Campinas, SP 13045-755, Brazil.
authors.forename: Fabiana Mantovani Gomes
authors.initials: FM
authors.lastname: França
authors.affiliation: Division of Cariology and Restorative Dentistry, São Leopoldo Mandic Institute and Dental Research Center, R. Dr José Rocha Junqueira 13, Campinas, SP 13045-755, Brazil.
authors.forename: Flávia Lucisano Botelho
authors.initials: FL
authors.lastname: Amaral
authors.affiliation: Division of Cariology and Restorative Dentistry, São Leopoldo Mandic Institute and Dental Research Center, R. Dr José Rocha Junqueira 13, Campinas, SP 13045-755, Brazil. Electronic address: cecilia.turssi@gmail.com.
authors.forename: Cecilia Pedroso
authors.initials: CP
authors.lastname: Turssi
mesh_terms: D000293:Adolescent; D000328:Adult; D000464:Alginates / Q000627:therapeutic use*; D000536:Aluminum Hydroxide / Q000627:therapeutic use*; D000818:Animals; D000863:Antacids / Q000627:therapeutic use*; D002417:Cattle; D018592:Cross-Over Studies; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology*; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D012824:Silicic Acid / Q000627:therapeutic use*; D017693:Sodium Bicarbonate / Q000627:therapeutic use*; D013535:Suspensions; D014077:Tooth Erosion / Q000517:prevention & control*; D014839:Vomiting / Q000150:complications
chemical_list: D000464:Alginates; D000863:Antacids; D004338:Drug Combinations; D009067:Mouthwashes; D013535:Suspensions; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D017693:Sodium Bicarbonate; D006851:Hydrochloric Acid
keywords: Antacid; Enamel; Erosion; Tooth wear