title: New Strategies in Cancer Nanomedicine.
abstract: We review recent progress in cancer nanomedicine, including stimulus-responsive drug delivery systems and nanoparticles responding to light for phototherapy or tumor imaging. In addition, several new strategies to improve the circulation of nanoparticles in vivo, tumor penetration, and tumor targeting are discussed. The application of nanomedicine in cancer immunology, a relatively new type of cancer therapy, is also highlighted.
authors.affiliation: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, and Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; email: daniel.kohane@childrens.harvard.edu.|Koch Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors.forename: Rong
authors.initials: R
authors.lastname: Tong
authors.affiliation: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, and Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; email: daniel.kohane@childrens.harvard.edu.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kohane
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: PEGylation; cancer immunology; circulation; nanomedicine; nanoparticle; self-immolative polymer; stimulus-responsive drug delivery; triggered drug delivery; tumor penetration; tumor targeting