title: [Calcium and vitamin D in bone metabolism: Clinical importance for fracture treatment].
abstract: A balanced calcium homeostasis is of critical importance not only for bone remodeling, the physiological process of bone resorption and bone formation that constantly renews bone throughout life but also for normal fracture healing. Given that disturbances of calcium homeostasis are present in 50 % of the German population and that this might result in delayed fracture healing after correct surgical treatment, this paper focusses on calcium and vitamin D in the daily practice in orthopedics and trauma surgery. To ensure the required enteral calcium uptake the following three conditions are required: (1) sufficient calcium intake via the nutrition, (2) a 25-hydroxyvitamin D serum level > 30 µg/l and (3) the presence of sufficient gastric acidification. Given the endemic vitamin D deficiency in Germany as well as the constantly increasing number of people using proton pump inhibitors on a regular basis, it is necessary to closely connect trauma orthopedic surgery and osteological treatment. The first issue to be dealt with is to control and if needed normalize calcium homeostasis in order to allow a normal undisturbed fracture healing process after both conservative as well as operative treatment of fractures.
authors.affiliation: Institut für Osteologie und Biomechanik, Universitätsklinikum Hamburg-Eppendorf, Lottestrasse 59, 22529, Hamburg, Deutschland. amling@uke.de.
authors.forename: M
authors.initials: M
authors.lastname: Amling
mesh_terms: D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D019317:Evidence-Based Medicine; D017102:Fracture Healing / Q000502:physiology*; D050723:Fractures, Bone / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D016896:Treatment Outcome; D014807:Vitamin D / Q000378:metabolism*
chemical_list: D014807:Vitamin D; D002118:Calcium
keywords: Calcium metabolism; Fracture therapy; Osteoporosis; Proton pump inhibitors; Vitamin D