title: Correction of aberrant imprinting by allele-specific epigenome editing.
abstract: Imprinting disorders are caused by the loss of the normal allele-specific DNA methylation at imprinting centers. Epigenetic editing is a promising approach to alter DNA methylation at defined genomic target regions. The novel development of CRISPR-Cas9-based DNA binding domains may allow for an allele-specific editing of DNA methylation at imprinted loci, for the first time offering a rational approach for correction of the molecular defects in imprinting disorders.
authors.affiliation: Institute of Biochemistry, Stuttgart University, Stuttgart, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Bashtrykov
authors.affiliation: Institute of Biochemistry, Stuttgart University, Stuttgart, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Kungulovski
authors.affiliation: Institute of Biochemistry, Stuttgart University, Stuttgart, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Jeltsch
mesh_terms: D000483:Alleles; D064113:CRISPR-Cas Systems / Q000235:genetics*; D025063:Chromosome Disorders / Q000235:genetics*; D019175:DNA Methylation / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D057890:Epigenomics; D018392:Genomic Imprinting / Q000235:genetics*; D006801:Humans