title: Can the Application of Fluoride Iontophoresis Improve Remineralisation of Early Caries Lesions?
abstract: OBJECTIVE
  To determine the optimal electric current intensity of fluoride iontophoresis (FI) for remineralisation of early caries lesions in vitro.
  
  
  METHODS
  Sixty specimens were made from bovine incisors and immersed in a demineralising gel for 96 h. Specimens were divided into control (conventional fluoride application) and experimental (FI) groups. All of the specimens were covered with fluoride for 4 min every day. Different electric current intensities (100, 200, 300 and 400 μA) were applied in the FI groups using the FI device. The concentration of KOH-soluble fluoride was determined to evaluate the amount of CaF2 formed on the tooth surface. The reduction in lesion depth was measured by polarised light microscopy.
  
  
  RESULTS
  The concentration of KOH-soluble fluoride was the highest in the specimens of the 300 μA FI group. However, there was no significant difference in the reduction of lesion depth between the experimental groups and the control group.
  
  
  CONCLUSIONS
  Variations in the electric current intensity influenced the amount of CaF2 formed on the enamel surface, with the greatest amount found for 300 μA.
authors.forename: Hee Eun
authors.initials: HE
authors.lastname: Kim
authors.forename: Baek-Il
authors.initials: BI
authors.lastname: Kim
mesh_terms: D000818:Animals; D002124:Calcium Fluoride / Q000493:pharmacokinetics; D002327:Cariostatic Agents / Q000008:administration & dosage*; D002417:Cattle; D003731:Dental Caries / Q000188:drug therapy*; D003743:Dental Enamel / Q000187:drug effects / Q000378:metabolism; D004560:Electricity; D006244:Hardness; D007478:Iontophoresis / Q000295:instrumentation / Q000379:methods*; D008422:Materials Testing; D008859:Microscopy, Polarization; D012464:Saliva, Artificial / Q000737:chemistry; D012969:Sodium Fluoride / Q000008:administration & dosage*; D014089:Tooth Remineralization / Q000295:instrumentation / Q000379:methods*
chemical_list: D002327:Cariostatic Agents; D012464:Saliva, Artificial; D012969:Sodium Fluoride; D002124:Calcium Fluoride