title: Multi-institutional outcomes using magnetic sphincter augmentation versus Nissen fundoplication for chronic gastroesophageal reflux disease.
abstract: Magnetic sphincter augmentation (MSA) has emerged as an alternative surgical treatment of gastroesophageal reflux disease (GERD). The safety and efficacy of MSA has been previously demonstrated, although adequate comparison to Nissen fundoplication (NF) is lacking, and required to validate the role of MSA in GERD management.
  
  
  
  A multi-institutional retrospective cohort study of patients with GERD undergoing either MSA or NF. Comparisons were made at 1 year for the overall group and for a propensity-matched group.
  
  
  
  A total of 415 patients (201 MSA and 214 NF) underwent surgery. The groups were similar in age, gender, and GERD-HRQL scores but significantly different in preoperative obesity (32 vs. 40 %), dysphagia (27 vs. 39 %), DeMeester scores (34 vs. 39), presence of microscopic Barrett's (18 vs. 31 %) and hiatal hernia (55 vs. 69 %). At a minimum of 1-year follow-up, 354 patients (169 MSA and 185 NF) had significant improvement in GERD-HRQL scores (pre to post: 21-3 and 19-4). MSA patients had greater ability to belch (96 vs. 69 %) and vomit (95 vs. 43 %) with less gas bloat (47 vs. 59 %). Propensity-matched cases showed similar GERD-HRQL scores and the differences in ability to belch or vomit, and gas bloat persisted in favor of MSA. Mild dysphagia was higher for MSA (44 vs. 32 %). Resumption of daily PPIs was higher for MSA (24 vs. 12, p = 0.02) with similar patient-reported satisfaction rates.
  
  
  
  MSA for uncomplicated GERD achieves similar improvements in quality of life and symptomatic relief, with fewer side effects, but lower PPI elimination rates when compared to propensity-matched NF cases. In appropriate candidates, MSA is a valid alternative surgical treatment for GERD management.
authors.affiliation: Division of Thoracic Surgery, Swedish Medical Center and Cancer Institute, 1101 Madison Street Suite 900, Seattle, WA, 98104, USA.
authors.forename: Heather F
authors.initials: HF
authors.lastname: Warren
authors.affiliation: Division of Upper GI and General Surgery, Keck Medical Center at University of Southern California, Los Angeles, CA, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Reynolds
authors.affiliation: Division of Upper GI and General Surgery, Keck Medical Center at University of Southern California, Los Angeles, CA, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Lipham
authors.affiliation: Division of Upper GI and General Surgery, Keck Medical Center at University of Southern California, Los Angeles, CA, USA.
authors.forename: Joerg
authors.initials: J
authors.lastname: Zehetner
authors.affiliation: Division of Upper GI and General Surgery, Keck Medical Center at University of Southern California, Los Angeles, CA, USA.
authors.forename: Nikolai A
authors.initials: NA
authors.lastname: Bildzukewicz
authors.affiliation: Knox Community Hospital, Mount Vernon, OH, USA.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Taiganides
authors.affiliation: Knox Community Hospital, Mount Vernon, OH, USA.
authors.forename: Jody
authors.initials: J
authors.lastname: Mickley
authors.affiliation: Division of Thoracic Surgery, Swedish Medical Center and Cancer Institute, 1101 Madison Street Suite 900, Seattle, WA, 98104, USA.
authors.forename: Ralph W
authors.initials: RW
authors.lastname: Aye
authors.affiliation: Division of Thoracic Surgery, Swedish Medical Center and Cancer Institute, 1101 Madison Street Suite 900, Seattle, WA, 98104, USA.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Farivar
authors.affiliation: Division of Thoracic Surgery, Swedish Medical Center and Cancer Institute, 1101 Madison Street Suite 900, Seattle, WA, 98104, USA. Brian.Louie@swedish.org.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Louie
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D049630:Esophageal Sphincter, Lower / Q000601:surgery; D005260:Female; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000628:therapy*; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay; D055909:Magnetic Field Therapy; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D017060:Patient Satisfaction; D011788:Quality of Life; D012189:Retrospective Studies
keywords: Anti-reflux surgery; Gastroesophageal reflux disease; Multi-institutional; Nissen fundoplication; Outcomes