title: Germline HOXB13 p.Gly84Glu mutation and cancer susceptibility: a pooled analysis of 25 epidemiological studies with 145,257 participates.
abstract: Numerous studies have investigated association between the germline HOXB13 p.Gly84Glu mutation and cancer risk. However, the results were inconsistent. Herein, we performed this meta-analysis to get a precise conclusion of the associations. A comprehensive literature search was conducted through Medline (mainly Pubmed), Embase, Cochrane Library databases. Crude odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated by STATA 12.1 software to evaluate the association of HOXB13 p.Gly84Glu mutation and cancer susceptibility. Then, 25 studies including 51,390 cases and 93,867 controls were included, and there was significant association between HOXB13 p.Gly84Glu mutation and overall cancer risk (OR = 2.872, 95% CI = 2.121-3.888, P < 0.001), particularly in prostate cancer (OR = 3.248, 95% CI = 2.313-4.560, P < 0.001), while no association was found in breast (OR = 1.424, 95% CI = 0.776-2.613, P = 0.253) and colorectal cancers (OR = 2.070, 95% CI = 0.485-8.841, P = 0.326). When we stratified analysis by ethnicity, significant association was found in Caucasians (OR = 2.673, 95%CI = 1.920-3.720, P < 0.001). Further well-designed with large samples and other various cancers should be performed to validate our results.
authors.affiliation: Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
authors.forename: Qiliang
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
authors.forename: Xinpeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Radiotherapy, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: Pharmaceutical Department, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Gong
authors.affiliation: Library of Tianjin Medical University, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
authors.forename: Kuo
authors.initials: K
authors.lastname: Yang
authors.affiliation: Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
authors.forename: Yuanjie
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Tianjin Institute of Infectious Diseases, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D019295:Computational Biology / Q000379:methods; D016021:Epidemiologic Studies; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D018095:Germ-Line Mutation; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D020125:Mutation, Missense; D009369:Neoplasms / Q000145:classification / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D012307:Risk Factors; D012984:Software; D044465:White People / Q000235:genetics
chemical_list: C484414:HOXB13 protein, human; D018398:Homeodomain Proteins
keywords: HOXB13 gene; cancer; genetic mutation; risk; rs138213197