title: [ASSOCIATION BETWEEN DIETARY GLYCEMIC INDEX AND GLYCEMIC LOAD AND INTIMA MEDIA THICKNESS IN A POPULATION AT HIGH CARDIOVASCULAR RISK: A SUBGROUP ANALYSIS IN THE PREDIMED TRIAL].
abstract: BACKGROUND
  increased carotid íntima-media thickness (IMT) is a marker of atherosclerosis and a predictor of future cardiovascular events. Although a beneficial effect of Mediterranean diets, in particular, enhanced with virgin olive oil and nuts, on longitudinal changes in IMT has been reported, the association between carbohydrates and the development of atherosclerosis is still unclear.
  
  
  OBJECTIVE
  to assess the association between glycemic index (IG) and glycemic load (CG) of the diet and intima media thickness (GIMC) in a population at high cardiovascular risk with no clinical symptoms.
  
  
  METHODS
  one hundred eighty seven participants of the PREDIMED-NAVARRA center (PREDIMED means in Spanish "PREvención con DIeta MEDiterránea") were randomly selected to undergo baseline and 1-year measurement of GIMC. Dietary information was collected at baseline and yearly using a validated 137-item food frequency questionnaire. Participants were categorized into four groups of energy-adjusted IG and CG intake. Multivariate analysis models (ANCOVA) were used to study the association between dietary IG and CG and GIMC and its changes.
  
  
  RESULTS
  in our study we found no significant association between IG or CG and GIMC at baseline or after one year.
authors.affiliation: Atención Primaria, Servicio Navarro de Salud, Osasunbidea, Pamplona. Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Navarra.. nuria_goni@yahoo.es.
authors.forename: Nuria
authors.initials: N
authors.lastname: Goñi Ruiz
authors.affiliation: Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Navarra. IdiSNA. Instituto de Investigación Sanitaria de Navarra. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid.. mamartinez@unav.es.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Martínez González
authors.affiliation: CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid. Unidad de Nutrición Humana, Facultad de Medicina y Ciencias de la Salud, Departamento de Bioquímica y Biotecnología, Universidad Rovira I Virgili, Reus.. jordi.salas@urv.cat.
authors.forename: Jordi
authors.initials: J
authors.lastname: Salas Salvadó
authors.affiliation: Atención Primaria, Servicio Navarro de Salud, Osasunbidea, Pamplona. IdiSNA. Instituto de Investigación Sanitaria de Navarra. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid.. pilar.buil.cosiales@cfnavarra.es.
authors.forename: Pilar
authors.initials: P
authors.lastname: Buil Cosiales
authors.affiliation: Atención Primaria, Servicio Navarro de Salud, Osasunbidea, Pamplona. IdiSNA. Instituto de Investigación Sanitaria de Navarra. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid.. Javier.diez.espino@cfnavarra.es.
authors.forename: Javier
authors.initials: J
authors.lastname: Diez Espino
authors.affiliation: Departamento de Neurología, Clínica-Universidad de Navarra, Pamplona.. emartinezv@unav.es.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Martinez Vila
authors.affiliation: Departamento de Neurología, Clínica-Universidad de Navarra, Pamplona.. pirimia@unav.es.
authors.forename: Pablo
authors.initials: P
authors.lastname: Irimia Sierra
authors.affiliation: CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid. Servicio de Endocrinología y Nutrición, Institutd'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic (Barcelona), España.. EROS@clinic.ub.es.
authors.forename: Emilio
authors.initials: E
authors.lastname: Ros Rahola
authors.affiliation: Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Navarra. IdiSNA. Instituto de Investigación Sanitaria de Navarra. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid.. etolefo@unav.es.
authors.forename: Estefania
authors.initials: E
authors.lastname: Toledo Atucha
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000209:etiology; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D059168:Carotid Intima-Media Thickness / Q000706:statistics & numerical data*; D004034:Diet Surveys; D038441:Diet, Mediterranean; D005260:Female; D038321:Glycemic Index; D000067940:Glycemic Load; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors