title: Aire Gets Company for Immune Tolerance.
abstract: A specialized subset of epithelial cells in the thymus "promiscuously" transcribes thousands of peripheral genes to ensure that developing T cells can test their antigen receptors for dangerous autoreactivity. New findings by Takaba et al. indicate that the transcription factor Fezf2 acts independently of Aire in thymic epithelial cells to generate "genetic noise" for immunological tolerance.
authors.affiliation: Institute for Immunology, University of Munich, Goethestr. 31, 80336 Munich, Germany. Electronic address: ludger.klein@med.uni-muenchen.de.
authors.forename: Ludger
authors.initials: L
authors.lastname: Klein
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D013950:Thymus Gland / Q000276:immunology*
chemical_list: D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C412364:Zfp312 protein, mouse