title: Systemic Staphylococcus aureus infection in restraint stressed mice modulates impaired immune response resulting in improved behavioral activities.
abstract: Stress leads to immune malfunction and increased susceptibility to infection resulting in impaired cognitive behavior and depression. Working with an animal model of Staphylococcus aureus infection and restraint stress we demonstrated impaired immune response and altered behavior against the S. aureus infection after exposure to acute or chronic restraint stress. This enhanced the resistance of mice to S. aureus infection via inhibiting the production of pro-inflammatory cytokines, free radicals, and upregulating corticosterone and anti-inflammatory cytokine production, resulting in altered exploratory behavior, compared to non-stressed infected group (P<0.05), thereby helping the animals to recover from depressive-like symptoms due to stress.
authors.affiliation: Department of Physiology, Immunology Laboratory, University of Calcutta, University Colleges of Science and Technology, 92 APC Road, Calcutta 700009, West Bengal, India.
authors.forename: Sayantika
authors.initials: S
authors.lastname: Mahanti
authors.affiliation: Department of Physiology, Immunology Laboratory, University of Calcutta, University Colleges of Science and Technology, 92 APC Road, Calcutta 700009, West Bengal, India.
authors.forename: Arnab
authors.initials: A
authors.lastname: Majhi
authors.affiliation: National Brain Research Centre, Manesar, Haryana 122051, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Kundu
authors.affiliation: National Brain Research Centre, Manesar, Haryana 122051, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Basu
authors.affiliation: Department of Physiology, Immunology Laboratory, University of Calcutta, University Colleges of Science and Technology, 92 APC Road, Calcutta 700009, West Bengal, India. Electronic address: biswadevbishayi4@gmail.com.
authors.forename: Biswadev
authors.initials: B
authors.lastname: Bishayi
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012149:Restraint, Physical; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus; D013315:Stress, Psychological / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines; D003345:Corticosterone
keywords: Behavior; Corticosterone; Cytokines; Immunity; Nitric oxide; Restraint stress; Staphylococcus aureus