title: Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease.
abstract: Non-alcoholic fatty liver disease (NAFLD) is the main cause of liver disease worldwide. NAFLD is linked to circumstances such as type 2 diabetes, insulin resistance, obesity, hyperlipidemia, and hypertension. Since the obesity figures and related comorbidities are increasing, NAFLD has turned into a liver problem that has become progressively more common. Currently, there is no effective drug therapy for NAFLD; therefore, interventions in lifestyles remain the first line of treatment. Bearing in mind that adherence rates to this type of treatment are poor, great efforts are currently focused on finding novel therapeutic agents for the prevention in the development of hepatic steatosis and its progression to nonalcoholic steatohepatitis and cirrhosis. This review presents a compilation of the scientific evidence found in the last years showing the results of interventions in lifestyle, diet, and behavioral therapies and research results in human, animal and cell models. Possible therapeutic agents ranging from supplementation with vitamins, amino acids, prebiotics, probiotics, symbiotics, polyunsaturated fatty acids and polyphenols to interventions with medicinal plants are analyzed.
authors.affiliation: Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile. cata.hernandezr@gmail.com.
authors.forename: Maria Catalina
authors.initials: MC
authors.lastname: Hernandez-Rodas
authors.affiliation: Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile. rvalenzuelab@med.uchile.cl.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Valenzuela
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 8380453, Chile. lvidela@med.uchile.cl.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Videla
mesh_terms: D000818:Animals; D004032:Diet; D006801:Humans; D008019:Life Style; D065626:Non-alcoholic Fatty Liver Disease / Q000178:diet therapy* / Q000188:drug therapy; D056692:Prebiotics
chemical_list: D056692:Prebiotics
keywords: NAFLD; amino acids; diet; exercise; lifestyle; medicinal plants; polyphenols; polyunsaturated fatty acids; prebiotics; vitamins