title: A hostel for the hostile: the bone marrow niche in hematologic neoplasms.
abstract: Our understanding of the biology of the normal hematopoietic stem cell niche has increased steadily due to improved murine models and sophisticated imaging tools. Less well understood, but of growing interest, is the interaction between cells in the bone marrow during the initiation, maintenance and treatment of hematologic neoplasms. This review summarizes the emerging concepts of the normal and leukemic hematopoietic bone marrow niche. Furthermore, it reviews current models of how the microenvironment of the bone marrow may contribute to or be modified by leukemogenesis. Finally, it provides the rationale for a "two-pronged" approach, directly targeting cancer cells themselves while also targeting the bone microenvironment to make it inhospitable to malignant cells and, ultimately, eradicating cancer stem-like cells.
authors.affiliation: Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany Krause@gsh.uni-frankfurt.de dscadden@mgh.harvard.edu.
authors.forename: Daniela S
authors.initials: DS
authors.lastname: Krause
authors.affiliation: Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, USA Krause@gsh.uni-frankfurt.de dscadden@mgh.harvard.edu.
authors.forename: David T
authors.initials: DT
authors.lastname: Scadden
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D006412:Hematopoietic Stem Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D055153:Stem Cell Niche; D059016:Tumor Microenvironment