title: In situ precision electrospinning as an effective delivery technique for cyanoacrylate medical glue with high efficiency and low toxicity.
abstract: The side effects or toxicity of cyanoacrylate used in vivo have been argued since its first application in wound closure. We propose an airflow-assisted in situ precision electrospinning apparatus as an applicator and make a detailed comparison with traditional spraying via in vitro and in vivo experiments. This novel method can not only improve operational performance and safety by precisely depositing cyanoacrylate fibers onto a wound, but significantly reduce the dosage of cyanoacrylate by almost 80%. A white blood cell count, liver function test and histological analysis prove that the in situ precision electrospinning applicator produces a better postoperative outcome, e.g., minor hepatocyte injury, moderate inflammation and the significant ability for liver regeneration. This in situ precision electrospinning method may thus dramatically broaden both civilian and military applications of cyanoacrylates.
authors.affiliation: Collaborative Innovation Center for Low-Dimensional Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, P. R. China. yunze.long@163.com.
authors.forename: R H
authors.initials: RH
authors.lastname: Dong
authors.affiliation: Collaborative Innovation Center for Low-Dimensional Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, P. R. China. yunze.long@163.com.
authors.forename: C C
authors.initials: CC
authors.lastname: Qin
authors.affiliation: Medical College, Qingdao University, Qingdao 266071, P. R. China. yuzhou7310@gmail.com.
authors.forename: X
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Collaborative Innovation Center for Low-Dimensional Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, P. R. China. yunze.long@163.com.
authors.forename: X
authors.initials: X
authors.lastname: Yan
authors.affiliation: Collaborative Innovation Center for Low-Dimensional Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, P. R. China. yunze.long@163.com and Department of Mechanical Engineering, Columbia University, New York 10027, USA.
authors.forename: M
authors.initials: M
authors.lastname: Yu
authors.affiliation: Medical College, Qingdao University, Qingdao 266071, P. R. China. yuzhou7310@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Cui
authors.affiliation: Medical College, Qingdao University, Qingdao 266071, P. R. China. yuzhou7310@gmail.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Collaborative Innovation Center for Low-Dimensional Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, P. R. China. yunze.long@163.com.
authors.forename: H D
authors.initials: HD
authors.lastname: Zhang
authors.affiliation: Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience & Technology, Beijing 100190, P. R. China. xingyujiang@nanoctr.cn.
authors.forename: X Y
authors.initials: XY
authors.lastname: Jiang
authors.affiliation: Collaborative Innovation Center for Low-Dimensional Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao 266071, P. R. China. yunze.long@163.com and Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Qingdao University, Qingdao 266071, P. R. China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Long
mesh_terms: D000818:Animals; D003487:Cyanoacrylates / Q000009:adverse effects / Q000494:pharmacology*; D022781:Hepatocytes / Q000378:metabolism* / Q000473:pathology; D008099:Liver / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014014:Tissue Adhesives / Q000009:adverse effects / Q000494:pharmacology*; D014947:Wounds and Injuries / Q000473:pathology / Q000628:therapy*
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives