title: Neoadjuvant chemotherapy in cervical cancer in pregnancy.
abstract: Cervical cancer is the most common gynecological cancer encountered in pregnancy. The standard treatment of early cervical cancer is usually surgical removal of the cervix (in selected cases) or, more commonly, the uterus. However, when cervical cancer develops during pregnancy, definitive surgical treatment often needs to be postponed until the fetus reaches maturity. Neoadjuvant chemotherapy (NACT) is an innovative approach in the management of these patients. It helps in controlling the disease and delaying delivery. The paper presents a literature review of the history of NACT, as well as practice points and agenda for further research.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics & Gynaecology, National University Hospital, Singapore. Electronic address: Ilancheran_arunachalam@nuhs.edu.sg.
authors.forename: Arunachalam
authors.initials: A
authors.lastname: Ilancheran
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
keywords: cervical cancer in pregnancy; fertility preservation; neoadjuvant chemotherapy