title: Impact of the automatic rounding-off function of the computerized physician order entry system on the ordering time and dose dispersion of chemotherapeutic drugs in regimens for hematologic malignancies.
abstract: BACKGROUND
  EGMAIN-GX is the computerized physician order entry system used in Japan. The automatic rounding-off of the calculated dose of chemotherapeutic drugs is an update in version 4, compared to version 2. We conducted a comparative study between EGMAIN-GX versions 2 and 4 to estimate the effect of the automatic rounding-off function on ordering time and dose dispersion.
  
  
  METHODS
  Twelve hematologists ordered 5 predefined chemotherapeutic regimens most commonly used in treating hematologic malignancies, twice for each regimen.
  
  
  RESULTS
  EGMAIN-GX version 4 significantly reduced ordering times compared to version 2 (635s vs. 259s, p<0.01). EGMAIN-GX version 4 also yielded a significantly higher ratio of actual to ideal doses of chemotherapeutic drugs than did version 2 (1.0097 and 0.9997, respectively; p<0.01) and a lower standard deviation (0.0275 and 0.0290, respectively).
  
  
  CONCLUSIONS
  The automatic rounding-off function could decrease the ordering time and dose dispersion of chemotherapeutic drugs.
authors.affiliation: Division of Hematology, Teikyo University Chiba Medical Center, Ichihara, Japan. Electronic address: thedod3@hotmail.com.
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsuda
authors.affiliation: Medical Information System Development, Teikyo University Chiba Medical Center, Ichihara, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Navitas Clinic, Tokyo, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanimoto
authors.affiliation: Solutions Department 1, Medical Solutions Division, Healthcare and Educational Solutions Unit, Fujitsu Limited, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takaba
authors.affiliation: Metropolitan Solutions Department, Healthcare Division 2, Healthcare Solutions Unit, Fujitsu Systems East Limited, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Okubo
authors.affiliation: Metropolitan Solutions Department, Healthcare Division 2, Healthcare Solutions Unit, Fujitsu Systems East Limited, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Ishii
authors.affiliation: Division of Hematology, Teikyo University Chiba Medical Center, Ichihara, Japan.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Division of Hematology, Teikyo University Chiba Medical Center, Ichihara, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Itokawa
authors.affiliation: Division of Hematology, Teikyo University Chiba Medical Center, Ichihara, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Isshiki
authors.affiliation: Division of Hematology, Teikyo University Chiba Medical Center, Ichihara, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Takei
authors.affiliation: Division of Hematology, Teikyo University Chiba Medical Center, Ichihara, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Solutions Department 1, Medical Solutions Division, Healthcare and Educational Solutions Unit, Fujitsu Limited, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakagawa
authors.affiliation: Division of Hematology, Teikyo University Chiba Medical Center, Ichihara, Japan.
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Komatsu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001331:Automation; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D050316:Medical Order Entry Systems
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapeutic drugs; Computerized physician order entry; Dose dispersion; Hematologic malignancy; Ordering time