title: Whole body vibration therapy: a novel potential treatment for type 2 diabetes mellitus.
abstract: There is a worsening epidemic of obesity and diabetes in the world. Life style interventions including dietary changes and increase in exercise can improve glucose metabolism and health in general. However, standard exercise programs are strenuous, time-consuming, and thus have low long-term compliance issues. We tested the feasibility of using high frequency, low amplitude whole body vibration (WBV) therapy to improve glucose metabolism in young type 2 diabetic (T2DM) mice. We also aimed to investigate the postulated anti-inflammatory and cytoprotective properties of WBV. Male db/db and db/m mice were exposed to high frequency, low-amplitude WBV. Outcome parameters comprised of body weight, hemoglobin A1c (HbA1c) level, as well as interleukin (IL)-17 (a marker of helper T cells), forkhead box P3 (Foxp3; a marker of regulatory T cells), and gammaH2AX (an index of DNA injury) expression. Furthermore, a 24 h metabolic cage study was carried out immediately after the WBV protocol and fluid intake, urine excretion and urine osmolality were determined. WBV did not affect body weight but improved HbA1c levels in db/db mice. Vibrated db/db mice demonstrated less fluid intake and urine excretion but better urinary concentrating ability than their non-vibrated controls. Pro-inflammatory changes were significantly reduced, as indicated by reduced IL-17 but increased Foxp3 expression. WBV reduced gammaH2AX in db/db mice suggestive of cytoprotective effect. However, WBV was largely without significant effects on assessed parameters in db/m mice. Collectively, our findings suggest that daily, short duration WBV may improve glycemic control, polydipsia, polyuria, and urine osmolality in T2DM in association with reduced inflammation. Thus, WBV may be a viable adjunctive treatment strategy in T2DM.
authors.affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA.|Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Peking, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA.|Palmetto Health/University of South Carolina School of Medicine, Columbia, SC USA.
authors.forename: Henrik O
authors.initials: HO
authors.lastname: Berdel
authors.affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA.
authors.forename: David
authors.initials: D
authors.lastname: Moore
authors.affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA.
authors.forename: Franklin
authors.initials: F
authors.lastname: Davis
authors.affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Mozaffari
authors.affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA.
authors.forename: Jack C
authors.initials: JC
authors.lastname: Yu
authors.affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA.
authors.forename: Babak
authors.initials: B
authors.lastname: Baban