title: Solid-Phase S-Alkylation Promoted by Molecular Sieves.
abstract: A solid-phase S-alkylation procedure to introduce chemical modification on the cysteine sulfhydryl group of a peptidyl resin is reported. The reaction is promoted by activated molecular sieves and consists of a solid-solid process, since both the catalyst and the substrate are in a solid state. The procedure was revealed to be efficient and versatile, particularly when used in combination with the solution S-alkylation approach, allowing for the introduction of different molecular diversities on the same peptide molecule.
authors.affiliation: Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy.
authors.forename: Enrica
authors.initials: E
authors.lastname: Calce
authors.affiliation: Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy.
authors.forename: Marilisa
authors.initials: M
authors.lastname: Leone
authors.affiliation: Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy.
authors.forename: Flavia Anna
authors.initials: FA
authors.lastname: Mercurio
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado , Boulder, Colorado 80309, United States.
authors.forename: Luca
authors.initials: L
authors.lastname: Monfregola
authors.affiliation: Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: De Luca
mesh_terms: D000478:Alkylation; D002853:Chromatography, Liquid; D003545:Cysteine / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D010455:Peptides; D013438:Sulfhydryl Compounds; D003545:Cysteine