title: A case of autoimmune epilepsy associated with anti-leucine-rich glioma inactivated subunit 1 antibodies manifesting electrical shock-like sensations and transparent sadness.
abstract: Autoimmune epilepsy is an isolated phenotype of autoimmune encephalitis, which may be suspected in patients with unexplained adult-onset seizure disorders or resistance to antiepileptic drugs (AEDs). Antibodies against leucine-rich glioma inactivated subunit 1 of the voltage-gated potassium channel (VGKC) complex, recently termed anti-LGI-1 antibodies, are one of the causes of autoimmune epilepsies. Bizarre symptoms with extremely short duration and high frequency are clues to the possible presence of autoimmune epilepsy with anti-LGI-1 antibodies. Precise diagnosis is important because autoimmune epilepsy is treatable and the prognosis can be predicted.
authors.affiliation: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Murata
authors.affiliation: Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Watanabe
authors.affiliation: Department of Neuropsychiatry, The University of Tokyo Hospital, Japan.
authors.forename: Go
authors.initials: G
authors.lastname: Taniguchi
authors.affiliation: Department of Neuropsychiatry, The University of Tokyo Hospital, Japan.
authors.forename: Daichi
authors.initials: D
authors.lastname: Sone
authors.affiliation: Department of Neuropsychiatry, The University of Tokyo Hospital, Japan.
authors.forename: Mao
authors.initials: M
authors.lastname: Fujioka
authors.affiliation: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan.
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Okazaki
authors.affiliation: Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakagawa
authors.affiliation: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Watanabe
keywords: Autoimmune epilepsy; Encephalitis; LGI-1; Limbic seizure; VGKC