title: Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais.
abstract: HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2(+)non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2(+)non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2(+)non-classical monocytes as an independent index of cognitive impairment.
authors.affiliation: Hawai'i Center for AIDS.|Department of Tropical Medicine, Medical Microbiology & Pharmacology.
authors.forename: Lishomwa C
authors.initials: LC
authors.lastname: Ndhlovu
authors.affiliation: Hawai'i Center for AIDS.|Department of Tropical Medicine, Medical Microbiology & Pharmacology.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: D'Antoni
authors.affiliation: SEARCH.|U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.|Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
authors.forename: Jintanat
authors.initials: J
authors.lastname: Ananworanich
authors.affiliation: Hawai'i Center for AIDS.|Department of Tropical Medicine, Medical Microbiology & Pharmacology.
authors.forename: Mary Margaret
authors.initials: MM
authors.lastname: Byron
authors.affiliation: Department of Tropical Medicine, Medical Microbiology & Pharmacology.
authors.forename: Thep
authors.initials: T
authors.lastname: Chalermchai
authors.affiliation: The Thai Red Cross AIDS Research Center, Bangkok, Thailand.
authors.forename: Pasiri
authors.initials: P
authors.lastname: Sithinamsuwan
authors.affiliation: Department of Tropical Medicine, Medical Microbiology & Pharmacology.
authors.forename: Somporn
authors.initials: S
authors.lastname: Tipsuk
authors.affiliation: Hawai'i Center for AIDS.
authors.forename: Erika
authors.initials: E
authors.lastname: Ho
authors.affiliation: U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.|Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
authors.forename: Bonnie M
authors.initials: BM
authors.lastname: Slike
authors.affiliation: U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.|Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schuetz
authors.affiliation: Department of Tropical Medicine, Medical Microbiology & Pharmacology.|Biostatistics and Data Management Core, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI, USA.
authors.forename: Guangxiang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Hawai'i Center for AIDS.|Department of Tropical Medicine, Medical Microbiology & Pharmacology.
authors.forename: Melissa
authors.initials: M
authors.lastname: Agsalda-Garcia
authors.affiliation: Hawai'i Center for AIDS.|Department of Tropical Medicine, Medical Microbiology & Pharmacology.
authors.forename: Bruce
authors.initials: B
authors.lastname: Shiramizu
authors.affiliation: Hawai'i Center for AIDS.
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Shikuma
authors.affiliation: Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Valcour
mesh_terms: D015526:AIDS Dementia Complex / Q000276:immunology*; D000328:Adult; D044466:Asian People; D003072:Cognition Disorders / Q000276:immunology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D009000:Monocytes / Q000276:immunology / Q000821:virology*; D054390:Receptors, CCR2 / Q000276:immunology; D013785:Thailand
chemical_list: C515334:CCR2 protein, human; D004279:DNA, Viral; D054390:Receptors, CCR2
keywords: C-C chemokine receptor (CCR) CCR2; CD163; HIV-associated neurocognitive disorders (HAND); Monocytes; Neopterin