title: Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals.
abstract: Multidrug resistance is a principal mechanism by which tumors become resistant to structurally and functionally unrelated anticancer drugs. Resistance to chemotherapy has been correlated with overexpression of p-glycoprotein (p-gp), a member of the ATP-binding cassette (ABC) superfamily of membrane transporters. P-gp mediates resistance to a broad-spectrum of anticancer drugs including doxorubicin, taxol, and vinca alkaloids by actively expelling the drugs from cells. Use of specific inhibitors/blocker of p-gp in combination with clinically important anticancer drugs has emerged as a new paradigm for overcoming multidrug resistance. The aim of this paper is to review p-gp regulation by dietary nutraceuticals and to correlate this dietary nutraceutical induced-modulation of p-gp with activity of anticancer drugs.
authors.affiliation: College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, P.R. China E-mail : khan2014@dlmedu.edu.cn.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Khan
authors.forename: Amara
authors.initials: A
authors.lastname: Maryam
authors.forename: Tahir
authors.initials: T
authors.lastname: Mehmood
authors.forename: Yaofang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tonghui
authors.initials: T
authors.lastname: Ma
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000037:antagonists & inhibitors*; D045784:Abietanes / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology; D000498:Allyl Compounds / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D052117:Benzodioxoles / Q000494:pharmacology; D044946:Biflavonoids / Q000494:pharmacology; D002211:Capsaicin / Q000494:pharmacology; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D002396:Catechols / Q000494:pharmacology; D003474:Curcumin / Q000494:pharmacology; D019587:Dietary Supplements; D018432:Drug Resistance, Multiple / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004357:Drug Synergism; D005233:Fatty Alcohols / Q000494:pharmacology; D011564:Furocoumarins / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D036701:Limonins / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010880:Piperidines / Q000494:pharmacology; D053284:Polyunsaturated Alkamides / Q000494:pharmacology; D044945:Proanthocyanidins / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D013440:Sulfides / Q000494:pharmacology; D013662:Tea; D014315:Triterpenes / Q000494:pharmacology; D024341:Xanthophylls / Q000494:pharmacology; D019207:beta Carotene / Q000494:pharmacology
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D045784:Abietanes; D000470:Alkaloids; D000498:Allyl Compounds; D000970:Antineoplastic Agents; D052117:Benzodioxoles; D044946:Biflavonoids; D002396:Catechols; D005233:Fatty Alcohols; D011564:Furocoumarins; D007211:Indoles; D036701:Limonins; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D044945:Proanthocyanidins; D013267:Stilbenes; D013440:Sulfides; D013662:Tea; D014315:Triterpenes; D024341:Xanthophylls; C502467:cnidiadin; C572783:kuguacin J; D019207:beta Carotene; C025164:fucoxanthin; C042577:diallyl trisulfide; C017674:procyanidin; C038491:allyl sulfide; D002392:Catechin; C007845:gingerol; D011794:Quercetin; C045651:epigallocatechin gallate; C016517:indole-3-carbinol; D003474:Curcumin; C001546:limonin; C018381:salvin; D000077185:Resveratrol; D002211:Capsaicin; C008922:piperine