title: A metabonomic investigation on the biochemical perturbation in post-stroke patients with depressive disorder (PSD).
abstract: A metabonomics study based on GC/MS and multivariate statistical analysis was performed involving 28 post stroke depressed (PSD) patients, 27 post-stroke non-depressed (PSND) patients and 33 healthy subjects to investigate the biochemical perturbation in their plasma samples. The outcome of this study showed that there was distinctive metabolic profile for PSD patients. Seven sentinel metabolites showed marked perturbations in PSD patients' blood. The introduction of metabonomics approach may provide a novel metabonomic insight about PSD and the sentinel metabolites for classifying PSD.
authors.affiliation: State Key Laboratory of Proteomics and Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, China.|State Key Laboratory of Medical Genetics and School of Life Science, Central South University, 110 Xiangya Road, Changsha, 410078, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Proteomics and Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, China.|Departmment of Cell Immunology, Institute of Basic Medical Sciences, Beijing, 100850, China.
authors.forename: Ruoxu
authors.initials: R
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Medical Genetics and School of Life Science, Central South University, 110 Xiangya Road, Changsha, 410078, China.
authors.forename: Wenkai
authors.initials: W
authors.lastname: Li
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410000, China.
authors.forename: Hengjia
authors.initials: H
authors.lastname: Ni
authors.affiliation: State Key Laboratory of Proteomics and Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Proteomics and Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Proteomics and Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, China. lionamms@hotmail.com.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Medical Genetics and School of Life Science, Central South University, 110 Xiangya Road, Changsha, 410078, China. jingliucsu@hotmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China. xiaobo_xy@126.com.|Department of Neurology, Xiangya Hospital, Central South University, 110 Xiangya Road, Changsha, Hunan, 410078, China. xiaobo_xy@126.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
authors.affiliation: State Key Laboratory of Proteomics and Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, China. 519935312@qq.com.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000097:blood*; D003866:Depressive Disorder / Q000150:complications* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D055432:Metabolomics / Q000379:methods; D008875:Middle Aged; D020521:Stroke / Q000097:blood* / Q000150:complications*; D000071939:Stroke Rehabilitation
keywords: GC/MS; Metabonomics; Post-stroke depression; Stroke rehabilitation