title: Pregnancy-associated plasma protein A gene polymorphism in pregnant women with preeclampsia and intrauterine growth restriction.
abstract: Preeclampsia (PE) and intrauterine growth restriction (IUGR) are still among the most commonly researched titles in perinatology. To shed light on their etiology, new prevention and treatment strategies are the major targets of studies. In this study, we aimed to investigate the relation between gene polymorphism of one of the products of trophoblasts, pregnancy-associated plasma protein A (PAPP-A) and PE/IUGR.A total of 147 women (IUGR, n = 61; PE, n = 47; IUGR + PE, n = 37; eclampsia, n = 2) were compared with 103 controls with respect to the sequencing of exon 14 of the PAPP-A gene to detect (rs7020782) polymorphism. Genotypes "AA" and "CC" were given in the event of A or C allele homozygosity and "AC" in A and C allele heterozygosity. Our findings revealed that the rate of AA, CC homozygotes, and AC heterozygotes did not differ between groups. Moreover, there was no difference in the distribution of PAPP-A genotypes among the patients with IUGR, PE, IUGR + PE, or eclampsia. Finally, birth weight, rate of the presence of proteinuria, and total protein excretion on 24-hour urine were similar in the subgroups of AA, AC, and CC genotypes in the study group. Our study demonstrated no association between PAPP-A gene rs7020782 polymorphism and PE/IUGR.
authors.affiliation: Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Sultan
authors.initials: S
authors.lastname: Ozkan
authors.affiliation: Department of Obstetrics and Gynaecology, Akdeniz University Faculty of Medicine, Antalya, Turkey. Electronic address: cemsanhal@gmail.com.
authors.forename: Cem Yasar
authors.initials: CY
authors.lastname: Sanhal
authors.affiliation: Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Yeniel
authors.affiliation: Department of Medical Genetics, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Arslan Ates
authors.affiliation: Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Mete
authors.initials: M
authors.lastname: Ergenoglu
authors.affiliation: Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Birol
authors.initials: B
authors.lastname: Bınbır
authors.affiliation: Department of Medical Genetics, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Onay
authors.affiliation: Department of Medical Genetics, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Ferda
authors.initials: F
authors.lastname: Ozkınay
authors.affiliation: Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Sermet
authors.initials: S
authors.lastname: Sagol
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000235:genetics*
chemical_list: D011266:Pregnancy-Associated Plasma Protein-A
keywords: Gene; Intrauterine growth restriction; PAPP-A; Polymorphism; Preeclampsia