title: Statistical Aspects in Proteomic Biomarker Discovery.
abstract: In the pursuit of a personalized medicine, i.e., the individual treatment of a patient, many medical decision problems are desired to be supported by biomarkers that can help to make a diagnosis, prediction, or prognosis. Proteomic biomarkers are of special interest since they can not only be detected in tissue samples but can also often be easily detected in diverse body fluids. Statistical methods play an important role in the discovery and validation of proteomic biomarkers. They are necessary in the planning of experiments, in the processing of raw signals, and in the final data analysis. This review provides an overview on the most frequent experimental settings including sample size considerations, and focuses on exploratory data analysis and classifier development.
authors.affiliation: Department of Medical Statistics, Georg-August-University Göttingen, Humboldtallee 32, 37073, Göttingen, Germany. kjung1@uni-goettingen.de.
authors.forename: Klaus
authors.initials: K
authors.lastname: Jung
mesh_terms: D015415:Biomarkers; D006801:Humans; D015233:Models, Statistical; D011379:Prognosis; D020543:Proteome; D040901:Proteomics / Q000379:methods* / Q000592:standards; D015203:Reproducibility of Results; D018401:Sample Size
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: Classifier; Cross-validation; Feature selection; Molecular signature s; Unsupervised learning