title: DEVELOPMENT AND VALIDATION OF TWO FOOD FREQUENCY QUESTIONNAIRES TO ASSESS GLUTEN INTAKE IN CHILDREN UP TO 36 MONTHS OF AGE.
abstract: OBJECTIVE
  precise information on gluten consumption is crucial for specifically studying the impact of gluten introduction and gluten intake in celiac disease development. Our aim was to develop and validate tools (food frequency questionnaires, FFQs) for the assessment of gluten consumption in Spanish children aged 7-36 months.
  
  
  METHODS
  a total of 342 children, who attended primary healthcare centers for routine health surveys or La Fe Hospital for minor health problems as well as healthy children (recruited in nurseries and primary schools) participated in this survey. We have developed two different FFQs (one for 7-12 months and other for 13-36 months). For validation, results from two FFQs were compared with results of 2-day food records and also with the gold standard 7-day records. The mean gluten intake obtained by the 2DR vs. FFQ and the 7DR vs. FFQ, were compared using the Bland Altman plot method and also Lin's concordance correlation coefficient.
  
  
  RESULTS
  we found a good agreement between our FFQs and the 2DR and 7DR according to the results of both the Bland-Altman plots and Lin's concordance correlation coefficient.
  
  
  CONCLUSIONS
  our two new FFQs are therefore the only validated questionnaires available to determine gluten consumption in Spanish children. They are user-friendly and offer excellent instruments to assess gluten intake in children up to 36 months of age.
authors.affiliation: Department of Pediatric Gastroenterology and Hepatology, La Fe University and Polytechnic Hospital, Valencia.. paula_crespo@iislafe.es.
authors.forename: Paula
authors.initials: P
authors.lastname: Crespo Escobar
authors.affiliation: Department of Pediatric Gastroenterology and Hepatology, La Fe University and Polytechnic Hospital, Valencia.. joaquin_calvo@iislafe.es.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Calvo Lerma
authors.affiliation: Instituto de Investigación Sanitaria La Fe, Department of Biostatistics, Valencia.. bioestadistica@iislafe.es.
authors.forename: David
authors.initials: D
authors.lastname: Hervas Marin
authors.affiliation: Department of Pediatric Gastroenterology and Hepatology, La Fe University and Polytechnic Hospital, Valencia.. donat_est@gva.es.
authors.forename: Ester
authors.initials: E
authors.lastname: Donat Aliaga
authors.affiliation: Department of Pediatric Gastroenterology and Hepatology, La Fe University and Polytechnic Hospital, Valencia.. etnamasip@yahoo.es.
authors.forename: Etna
authors.initials: E
authors.lastname: Masip Simó
authors.affiliation: Department of Pediatric Gastroenterology and Hepatology, La Fe University and Polytechnic Hospital, Valencia.. begojavea@hotmail.com.
authors.forename: Begoña
authors.initials: B
authors.lastname: Polo Miquel
authors.affiliation: Department of Pediatric Gastroenterology and Hepatology, La Fe University and Polytechnic Hospital, Valencia. Head of the Pediatric Gastroenterology and Hepatology Unit, La Fe University and Polytechnic Hospital (Valencia), Spain.. ribes_car@gva.es.
authors.forename: Carmen
authors.initials: C
authors.lastname: Ribes Koninckx
mesh_terms: D002446:Celiac Disease / Q000453:epidemiology / Q000209:etiology; D002675:Child, Preschool; D004032:Diet / Q000706:statistics & numerical data*; D015930:Diet Records; D004034:Diet Surveys / Q000379:methods*; D005260:Female; D005983:Glutens; D006801:Humans; D007223:Infant; D008297:Male; D015203:Reproducibility of Results; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D005983:Glutens