title: The role of non-receptor protein tyrosine kinases in the excitotoxicity induced by the overactivation of NMDA receptors.
abstract: Protein tyrosine phosphorylation is one of the primary modes of regulation of N-methyl-d-aspartate (NMDA) receptors. The non-receptor tyrosine kinases are one of the two types of protein tyrosine kinases that are involved in this process. The overactivation of NMDA receptors is a primary reason for neuron death following cerebral ischemia. Many studies have illustrated the important role of non-receptor tyrosine kinases in ischemia insults. This review introduces the roles of Src, Fyn, focal adhesion kinase, and proline-rich tyrosine kinase 2 in the excitotoxicity induced by the overactivation of NMDA receptors following cerebral ischemia.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Sun
authors.forename: You
authors.initials: Y
authors.lastname: Chen
authors.forename: Liying
authors.initials: L
authors.lastname: Zhan
authors.forename: Linan
authors.initials: L
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Hu
authors.forename: Zibin
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D016194:Receptors, N-Methyl-D-Aspartate; D011505:Protein-Tyrosine Kinases