title: A randomized controlled trial of an internet-delivered treatment: Its potential as a low-intensity community intervention for adults with symptoms of depression.
abstract: BACKGROUND
  Internet-delivered treatments for depression have proved successful, with supported programs offering the potential for improved adherence and outcomes. Internet interventions are particularly interesting in the context of increasing access to interventions, and delivering interventions population-wide.
  
  
  METHODS
  The study was a randomized controlled trial of an 7-module internet-delivered cognitive behavioral therapy (iCBT) program for adults with depressive symptoms (n = 96) compared to a waiting-list control group (n = 92). Participants received weekly support from a trained supporter. The primary outcome was depressive symptoms as measured by the Beck Depression Inventory (BDI-II). The program was made available nationwide from an established and recognized charity for depression.
  
  
  RESULTS
  For the treatment group, post-treatment effect sizes reported were large for the primary outcome measure (d = 0.91). The between-group effects were moderate to large and statistically significant for the primary outcomes (d = 0.50) favoring the treatment group. Gains were maintained at 6-month follow-up.
  
  
  CONCLUSIONS
  The study has demonstrated the efficacy of the internet-delivered Space from Depression treatment. Participants demonstrated reliable and statistically significant changes in symptoms from pre-to post-intervention. The study supports a model for delivering online depression interventions population-wide using trained supporters.
  
  
  BACKGROUND
  Current Controlled Trials ISRCTN03704676. http://dx.doi.org/10.1186/ISRCTN03704676.
authors.affiliation: SilverCloud Health, The Priory, John's Street West, Dublin, Ireland; School of Psychology, Trinity College Dublin, Ireland. Electronic address: Derek.Richards@tcd.ie.
authors.forename: D
authors.initials: D
authors.lastname: Richards
authors.affiliation: School of Psychology, Trinity College Dublin, Ireland.
authors.forename: L
authors.initials: L
authors.lastname: Timulak
authors.affiliation: SilverCloud Health, The Priory, John's Street West, Dublin, Ireland.
authors.forename: E
authors.initials: E
authors.lastname: O'Brien
authors.affiliation: Aware National Charity, 72 Lower Leeson Street, Dublin 2, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Hayes
authors.affiliation: SilverCloud Health, The Priory, John's Street West, Dublin, Ireland.
authors.forename: N
authors.initials: N
authors.lastname: Vigano
authors.affiliation: Parents Plus Charity, Dublin, Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Sharry
authors.affiliation: School of Computer Science and Statistics, Trinity College, Dublin, Ireland.
authors.forename: G
authors.initials: G
authors.lastname: Doherty
mesh_terms: D000328:Adult; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003863:Depression / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012111:Residence Characteristics; D013813:Therapy, Computer-Assisted / Q000379:methods*; D014850:Waiting Lists
keywords: CBT; Depression; Internet-delivered; Online interventions; Population health; Randomized trial; Symptoms; Treatment