title: Sex-Related Differences in the Sensitivity to Carcinogenic Effect of Urethane on the Lungs in Mice Are Reversed after Neonatal Androgenization.
abstract: Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before carcinogen challenge reduced the number of lung adenomas caused by it in males and somewhat increased the number of tumors in females. Exogenous testosterone after urethane injection caused virtually no changes in urethane effect in males and females. By contrast, elevation of testosterone concentrations in newborn male and female mice by injections or its decrease in feminized males receiving sodium glutamate during the neonatal period reduced the sensitivity to the carcinogenic effect of urethane in adult males and to its increase in females.
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia. pathol@inbox.ru.
authors.forename: T S
authors.initials: TS
authors.lastname: Morozkova
authors.affiliation: nstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Kaledin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance / Q000187:drug effects; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D008175:Lung Neoplasms / Q000473:pathology / Q000517:prevention & control; D008297:Male; D051379:Mice; D011247:Pregnancy; D012727:Sex Characteristics; D014520:Urethane / Q000494:pharmacology*; D014770:Virilism / Q000473:pathology*
chemical_list: D002273:Carcinogens; D014520:Urethane
keywords: gonadectomy; induced pulmonary adenomas; neonatal androgenization; sexrelated differences in urethane sensitivity