title: Motoric cognitive risk syndrome and risk of mortality in older adults.
abstract: Cognitive impairment is associated with increased mortality. We examined the association between motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and cognitive complaints, and survival.
  
  
  
  A total of 11,867 nondemented participants aged >65 years from three established cohort studies in the United States and Europe were screened for MCR. Mortality risk of MCR was assessed with Cox and logistic regression models.
  
  
  
  At baseline, 836 (7.0%) participants had MCR. Over a median follow-up of 28 months, 1603 participants died (758 in first 2 years). MCR was associated with increased mortality overall (adjusted hazard ratio, 1.69; 95% confidence interval [CI], 1.46-1.96) and 2-year mortality (adjusted odds ratio, 1.89; 95% CI, 1.50-2.38). The association remained after accounting for established mortality risk factors as well as baseline gait speed and memory performance.
  
  
  
  MCR is associated with increased mortality. Older adults should be screened for MCR to identify at-risk individuals for dementia and death.
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: Emmeline.ayers@einstein.yu.edu.
authors.forename: Emmeline
authors.initials: E
authors.lastname: Ayers
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Joe
authors.initials: J
authors.lastname: Verghese
mesh_terms: D000367:Age Factors; D000368:Aged; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis; D015331:Cohort Studies; D003704:Dementia / Q000209:etiology; D042241:Early Diagnosis; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D009026:Mortality / Q000639:trends*; D012307:Risk Factors
keywords: Cognitive impairment; Dementia; Gait speed; Mortality; Motoric cognitive risk syndrome; Predementia syndromes