title: A high performance Schiff-base fluorescent probe for monitoring Au(3+) in zebrafish based on BODIPY.
abstract: We designed and synthesized a mono-Schiff-base fluorescent probe (Probe 1) based on a boron-dipyrromethene (BODIPY) dye. By investigating the recognition of Au(3+) through an irreversible C=N bond hydrolysis reaction, Probe 1 exhibited higher properties such as acting as a "naked eye" probe, stability to pH, fast-response of 90s, a lower detection limit of 60 nM, stronger antijamming capability, and better live-cells imaging with low cytotoxicity compared with other probes. Even in relatively high temperatures, Probe 1 maintained its own excellent characteristic. More importantly, this is the first time that one chemosensor could be successfully applied to Au(3+) imaging in zebrafish, which demonstrated the performance that Probe 1 exhibited wonderful organism permeability.
authors.affiliation: Institute of Environmental and Analytical Sciences, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, PR China.
authors.forename: Enze
authors.initials: E
authors.lastname: Wang
authors.affiliation: Institute of Environmental and Analytical Sciences, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, PR China.
authors.forename: Lanfang
authors.initials: L
authors.lastname: Pang
authors.affiliation: Institute of Environmental and Analytical Sciences, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, PR China. Electronic address: zhouyanmei@henu.edu.cn.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Plant Stress Biology, Henan University, Kaifeng 475004, PR China.
authors.forename: Junli
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Environmental and Analytical Sciences, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.affiliation: Institute of Environmental and Analytical Sciences, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, PR China.
authors.forename: Han
authors.initials: H
authors.lastname: Qiao
authors.affiliation: Pharmaceutical Institute, Henan University, Kaifeng 475004, PR China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Pang
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006046:Gold / Q000378:metabolism*; D008856:Microscopy, Fluorescence / Q000379:methods*; D015203:Reproducibility of Results; D012545:Schiff Bases / Q000737:chemistry*; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D051598:Whole Body Imaging / Q000379:methods; D015027:Zebrafish / Q000378:metabolism*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D012545:Schiff Bases; D006046:Gold
keywords: Au(3+); Fluorescent probe; Live-cells imaging; Schiff-base; Zebrafish imaging