title: Trans-arterial Chemo-Embolization in Treating Elderly Patients with Hepatocellular Carcinoma.
abstract: BACKGROUND
  This analysis was conducted to evaluate the efficacy and safety of Trans-arterial Chemo- Embolization (TACE) in treating Elderly patients with Hepatocellular Carcinoma (EHPC).
  
  
  METHODS
  Clinical studies evaluating the efficacy and safety of TACE on response and safety for patients with EHPC were identified by using a predefined search strategy. Pooled response rate of treatment were calculated.
  
  
  RESULTS
  In TACE based regimen, clinical studies which including patients with EHPC were considered eligible for the evaluation of response. And, in these TACE based treatments, pooled analysis suggested that, in all 288 patients whose response could be assessed, the pooled reponse rate was 29.5%(85/288) in TACE based treatment. The most commonly encountered TACE-related morbidity was liver function impairment. No grade III or IV renal or liver toxicity were observed. No treatment related death occurred in EHPC patients with TACE based treatments.
  
  
  CONCLUSIONS
  This evidence based analysis suggests that TACE based treatments are associated with mild response rate and accepted toxicities for treating patients with EHPC.
authors.affiliation: The Second People's Hospital of Nanjing, Nanjing, China E-mail : njzq83626472@sina.com.
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Zhang
authors.forename: Jun-Mao
authors.initials: JM
authors.lastname: Liu
authors.forename: Nin
authors.initials: N
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Du
authors.forename: Qin
authors.initials: Q
authors.lastname: Zheng
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012074:Remission Induction