title: Altered serum and salivary C-reactive protein levels in patients with oral premalignant lesions and oral squamous cell carcinoma.
abstract: Chronic inflammation is associated with cancer development. C-reactive protein (CRP), an acute phase protein synthesized primarily in the liver, is a marker for inflammation and for the progression of many cancers. We compared serum and salivary CRP levels in 20 normal individuals, 20 patients with oral premalignant lesions and 20 patients with oral squamous cell carcinoma (OSCC) to assess its efficacy as a prognostic indicator for OSCC. Saliva and blood samples were obtained and evaluated for CRP levels. Mean CRP levels were higher in patients with oral premalignant lesions compared to controls. CRP levels in OSCC patients were elevated and were associated with advanced tumor stages.
authors.affiliation: a Department of Oral and Maxillofacial Pathology , Pacific Dental College and Hospital, Paher University , Udaipur , India.
authors.forename: R
authors.initials: R
authors.lastname: Metgud
authors.affiliation: a Department of Oral and Maxillofacial Pathology , Pacific Dental College and Hospital, Paher University , Udaipur , India.
authors.forename: S
authors.initials: S
authors.lastname: Bajaj
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein
keywords: C-reactive protein; inflammation; oral cancer; premalignant lesion; squamous cell carcinoma