title: [Donor cell leukemia (DCL): A prospective study of its identification and treatment].
abstract: Donor-derived malignancies after allogeneic hematopoietic stem cell transplantation and after solid organ transplantation are considered as rare diseases. We have prospectively searched for donor cell leukemia in a 12-year period, in a single institution, in a group of 106 consecutive patients allografted because of leukemia. We have identified seven cases of donor cell leukemia; six were allografted because of relapsed acute lymphoblastic leukemia and one because of paroxysmal nocturnal hemoglobinuria/aplastic anemia. These figures suggest that the real incidence of donor cell leukemia has been underestimated. The six patients with lymphoblastic donor cell leukemia were treated prospectively with a pediatric-inspired combined chemotherapy schedule designed for de novo acute leukemia. A complete response was obtained in three out of six patients with lymphoblastic donor cell leukemia. It is possible to obtain favorable responses in donor cell leukemia patients employing combined chemotherapy. The long-term donor cell leukemia survivors remain as full chimeras and have not needed a second transplant.
authors.affiliation: Centro de Hematología y Medicina Interna, Clínica Ruiz de Puebla, Puebla, Pue., México.|Laboratorios Clínicos de Puebla, Clínica Ruiz de Puebla, Puebla, Pue., México.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Pue., México.
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Ruiz-Delgado
authors.affiliation: Centro de Hematología y Medicina Interna, Clínica Ruiz de Puebla, Puebla, Pue., México.|Universidad del Valle de México, Villahermosa, Tab., México.
authors.forename: Jesús
authors.initials: J
authors.lastname: Hernández-Reyes
authors.affiliation: Centro de Hematología y Medicina Interna, Clínica Ruiz de Puebla, Puebla, Pue., México.|Universidad de las Américas Puebla, Puebla, Pue., México.
authors.forename: Mónica Patricia
authors.initials: MP
authors.lastname: González-Ramírez
authors.affiliation: Centro de Hematología y Medicina Interna, Clínica Ruiz de Puebla, Puebla, Pue., México.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Pue., México.
authors.forename: Nora Ángela
authors.initials: NÁ
authors.lastname: Martagón-Herrera
authors.affiliation: Laboratorios Clínicos de Puebla, Clínica Ruiz de Puebla, Puebla, Pue., México.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Pue., México.
authors.forename: Javier
authors.initials: J
authors.lastname: Garcés-Eisele
authors.affiliation: Laboratorios Clínicos de Puebla, Clínica Ruiz de Puebla, Puebla, Pue., México.|Universidad de las Américas Puebla, Puebla, Pue., México.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Ruiz-Argüelles
authors.affiliation: Laboratorios Clínicos de Puebla, Clínica Ruiz de Puebla, Puebla, Pue., México.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Pue., México.
authors.forename: Angélica
authors.initials: A
authors.lastname: González-Cortés
authors.affiliation: Centro de Hematología y Medicina Interna, Clínica Ruiz de Puebla, Puebla, Pue., México.|Laboratorios Clínicos de Puebla, Clínica Ruiz de Puebla, Puebla, Pue., México.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Pue., México.|Universidad de las Américas Puebla, Puebla, Pue., México.
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D011446:Prospective Studies; D014019:Tissue Donors; D055815:Young Adult