title: The effect of vitamin D supplementation on insulin and glucose metabolism in overweight and obese individuals: systematic review with meta-analysis.
abstract: The aim of this systematic review was to assess the effect of vitamin D supplementation on glucose and insulin metabolism in overweight and obese subjects. The search process was based on the selection of publications listed in the databases: PubMed, Scopus, Web of Knowledge, Embase and the Cochrane library that met the inclusion criteria. Twelve randomized controlled trials were included. The analysed population consisted of 1181 individuals with BMIs > 23 kg/m2. Changes in the concentration of 25(OH)D, fasting glucose, insulin and the HOMA-IR index were assessed. In the meta-regression analysis, a restricted maximum likelihood method was applied. To combine individual study results, a meta-analysis was performed. Vitamin D supplementation did not have an effect on glucose concentrations, insulin level and HOMA-IR values when the supplemented dose, time of supplementation and baseline of 25(OH)D concentration were taken under consideration in subgroup-analysis. This meta-analysis provides evidence that vitamin D supplementation has no significant effect on glucose and insulin metabolism in overweight and obese individuals.
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, 31 Wojska Polskiego Str., 60-624 Poznan, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Jamka
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, 31 Wojska Polskiego Str., 60-624 Poznan, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Woźniewicz
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, 31 Wojska Polskiego Str., 60-624 Poznan, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Jeszka
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, 31 Wojska Polskiego Str., 60-624 Poznan, Poland.|Department of Oncology, Poznan University of Medical Sciences, 82/84 Szamarzewskiego Str., 60-569 Poznan, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Mardas
authors.affiliation: Department of Education and Obesity Treatment and Metabolic Disorders, Poznan University of Medical Sciences, 84 Szamarzewskiego Str., 60-596 Poznan, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Bogdański
authors.affiliation: German Institute of Human Nutrition Potsdam-Rehbruecke, 114-116 Arthur-Scheunert-Allee, 14558 Nuthetal, Germany.|Department of Paediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 27/33 Szpitalna Str., 60-572 Poznan, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Stelmach-Mardas
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism*; D019587:Dietary Supplements; D005215:Fasting / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D050177:Overweight / Q000378:metabolism*; D014807:Vitamin D / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014807:Vitamin D; D005947:Glucose