title: Fluid flow and particle transport in mechanically ventilated airways. Part II: particle transport.
abstract: The flow mechanisms that play a role on aerosol deposition were identified and presented in a companion paper (Timothy et al. in Med Biol Eng Comput. doi: 10.1007/s11517-015-1407-3 , 2015). In the current paper, the effects of invasive conventional mechanical ventilation waveforms and endotracheal tube (ETT) on the aerosol transport were investigated. In addition to the enhanced deposition seen at the carinas of the airway bifurcations, enhanced deposition was also seen in the right main bronchus due to impaction and turbulent dispersion resulting from the fluid structures created by jet caused by the ETT. The orientation of the ETT toward right bronchus resulted in a substantial deposition inside right lung compared to left lung. The deposition inside right lung was ~12-fold higher than left lung for all considered cases, except for the case of using pressure-controlled sinusoidal waveform where a reduction of this ratio by ~50 % was found. The total deposition during pressure constant, volume ramp, and ascending ramp waveforms was similar and ~1.44 times higher than deposition fraction when using pressure sinusoidal waveform. Varying respiratory waveform demonstrated a significant role on the deposition enhancement factors and give evidence of drug aerosol concentrations in key deposition sites, which may be significant for drugs with negative side effects in high concentrations. These observations are thought to be important for ventilation treatment strategy.
authors.affiliation: Department of Mechanical Engineering and Mechanics, Packard Laboratory, Lehigh University, Bethlehem, PA, 18015, USA.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alzahrany
authors.affiliation: Department of Mechanical and Aerospace Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Van Rhein
authors.affiliation: Department of Mechanical Engineering and Mechanics, Packard Laboratory, Lehigh University, Bethlehem, PA, 18015, USA. arb612@lehigh.edu.
authors.forename: Arindam
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Respiratory and Critical Care Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, MO, 64108, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Salzman
mesh_terms: D000336:Aerosols; D001980:Bronchi / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D007442:Intubation, Intratracheal / Q000295:instrumentation / Q000379:methods*; D008168:Lung / Q000502:physiology; D010316:Particle Size; D012121:Respiration, Artificial / Q000379:methods*; D014132:Trachea / Q000502:physiology*
chemical_list: D000336:Aerosols
keywords: Endotracheal tube; Large eddy simulation; Local particle deposition; Mechanical ventilation; Particle deposition