title: [Effect of melaxen on free radical processes intensity and some antioxidant enzymes activity in rats liver and blood serum under type 2 diabetes mellitus].
abstract: The effect of melaxen on free radical processes and activity of superoxide dismutase and catalase in rats with type 2 diabetes mellitus (T2DM) has been investigated. It was established that melaxen administration to diabetic rats caused a decrease of the intensity of free radical processes as evidenced a decrease of the lipid peroxidation primary products content and biochemiluminescence parameters. The activity of the antioxidant enzymes changed towards normal values. These effects were probably induced by the correction of the melatonin level at the result of the melaxen action.
authors.affiliation: Voronezh State University, Voronezh, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Verevkin
authors.affiliation: Voronezh State University, Voronezh, Russia.
authors.forename: T N
authors.initials: TN
authors.lastname: Popova
authors.affiliation: Voronezh State University, Voronezh, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Agarkov
authors.affiliation: Voronezh State University, Voronezh, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Semenikhina
mesh_terms: D000475:Alkenes / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005609:Free Radicals / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005978:Glutathione / Q000819:agonists / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D011479:Protamines; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000475:Alkenes; D000975:Antioxidants; D005609:Free Radicals; D011479:Protamines; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D008550:Melatonin
keywords: biochemiluminescence; catalase; conjugated dienes; melaxen; superoxide dismutase; type 2 diabetes mellitus