title: Photoacoustic and Colorimetric Visualization of Latent Fingerprints.
abstract: There is a high demand on a simple, rapid, accurate, user-friendly, cost-effective, and nondestructive universal method for latent fingerprint (LFP) detection. Herein, we describe a combination imaging strategy for LFP visualization with high resolution using poly(styrene-alt-maleic anhydride)-b-polystyrene (PSMA-b-PS) functionalized gold nanoparticles (GNPs). This general approach integrates the merits of both colorimetric imaging and photoacoustic imaging. In comparison with the previous methods, our strategy is single-step and does not require the signal amplification by silver staining. The PSMA-b-PS functionalized GNPs have good stability, tunable color, and high affinity for universal secretions (proteins/polypeptides/amino acids), which makes our approach general and flexible for visualizing LFPs on different substrates (presumably with different colors) and from different people. Moreover, the unique optical property of GNPs enables the photoacoustic imaging of GNPs-deposited LFPs with high resolution. This allows observation of level 3 hyperfine features of LFPs such as the pores and ridge contours by photoacoustic imaging. This technique can potentially be used to identify chemicals within LFP residues. We believe that this dual-modality imaging of LFPs will find widespread use in forensic investigations and medical diagnostics.
authors.affiliation: School of Life Science, Changchun Normal University , Changchun 130032, China.|Department of Chemistry and Biochemistry, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Kai
authors.initials: K
authors.lastname: Song
authors.affiliation: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering, School of Medicine, Shenzhen University , Shenzhen 518060, China.|Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health , Bethesda, Maryland 20892, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Chenglin
authors.initials: C
authors.lastname: Yi
authors.affiliation: Department of Biomedical Engineering, University of Virginia , Charlottesville, Virginia 22903, United States.
authors.forename: Bo
authors.initials: B
authors.lastname: Ning
authors.affiliation: Department of Biomedical Engineering, University of Virginia , Charlottesville, Virginia 22903, United States.
authors.forename: Song
authors.initials: S
authors.lastname: Hu
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health , Bethesda, Maryland 20892, United States.
authors.forename: Liming
authors.initials: L
authors.lastname: Nie
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health , Bethesda, Maryland 20892, United States.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Nie
mesh_terms: D003124:Colorimetry / Q000379:methods*; D003878:Dermatoglyphics; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D061088:Photoacoustic Techniques / Q000379:methods*
chemical_list: D006046:Gold
keywords: block copolymer; colorimetric imaging; gold nanoparticles; latent fingerprints; photoacoustic imaging