title: A useful and easy to develop combined stress test for myocardial perfusion imaging: Regadenoson and isometric exercise, preliminary results.
abstract: Regadenoson, a selective A2a receptor agonist, is a vasodilator increasingly used in myocardial perfusion imaging. Adjunction of isometric exercise is a simple method that could improve side effect profile while providing better image quality.
  
  
  
  Patients undergoing SPECT MPI were prospectively enrolled in handgrip-Regadenoson (HG-Reg test, N = 20) and Regadenoson (Reg) stress test (N = 40). Investigator blinded to stress test analyzed clinical data and images.
  
  
  
  Heart rate (HR) increase was statistically higher in the HG-Reg group (27 vs 22 bpm, P = .019). Decrease in SBP was less frequent in the HG-Reg group than in the Reg group (55% vs 85.5%, P = .005), there were less drops >10 mmHg (45% vs 77.7%, P = .012). During stress testing, fewer subjects reported at least one side effect in the HG-Reg compared to Reg group (70% vs 92.5%, P = .021). Images were more often classified as good in the HG-Reg group (75% vs 52.5% in the Reg group, P = .25).
  
  
  
  Adjunction of handgrip exercise to Regadenoson administration is a well-tolerated and easy method, without loss of time. Furthermore, image quality seems to be better.
authors.affiliation: CHU de Nancy, Service de Médecine Nucléaire, Hôpital Brabois, 54500, Vandoeuvre-lès-Nancy, France. luciljanvier@gmail.com.|CHU de Bordeaux, Service de Médecine Nucléaire, 33000, Bordeaux, France. luciljanvier@gmail.com.
authors.forename: Lucile
authors.initials: L
authors.lastname: Janvier
authors.affiliation: CHU de Bordeaux, Service de Médecine Nucléaire, 33000, Bordeaux, France.
authors.forename: J
authors.initials: J
authors.lastname: Pinaquy
authors.affiliation: CHU de Bordeaux, Service de cardiologie, 33000, Bordeaux, France.
authors.forename: H
authors.initials: H
authors.lastname: Douard
authors.affiliation: CHU de Nancy, Service de Médecine Nucléaire, Hôpital Brabois, 54500, Vandoeuvre-lès-Nancy, France.
authors.forename: G
authors.initials: G
authors.lastname: Karcher
authors.affiliation: CHU de Bordeaux, Service de Médecine Nucléaire, 33000, Bordeaux, France.
authors.forename: L
authors.initials: L
authors.lastname: Bordenave
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D018737:Hand Strength; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007537:Isometric Contraction; D008297:Male; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011687:Purines; D011720:Pyrazoles; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014665:Vasodilator Agents
chemical_list: D011687:Purines; D011720:Pyrazoles; D014665:Vasodilator Agents; C430916:regadenoson
keywords: Exercise stress; Regadenoson; myocardial perfusion imaging; vasodilator stress