title: Comparative effectiveness of long-acting antipsychotics: issues and challenges from a pragmatic randomised study.
abstract: Although long-acting antipsychotics are widely used in individuals with psychotic disorders, it is unclear which long-acting preparation should be considered as first-line treatment in clinical practice. In this commentary, the main strengths and weaknesses of a recently published pragmatic randomised study comparing long-acting paliperidone palmitate v. long-acting haloperidol decanoate are briefly analysed.
authors.affiliation: Department of Public Health and Community Medicine,Section of Psychiatry,University of Verona,Verona,Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ostuzzi
authors.affiliation: Department of Public Health and Community Medicine,Section of Psychiatry,University of Verona,Verona,Italy.
authors.forename: C
authors.initials: C
authors.lastname: Barbui
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D000068882:Paliperidone Palmitate / Q000627:therapeutic use*; D011618:Psychotic Disorders; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol; D000068882:Paliperidone Palmitate
keywords: Effectiveness; long-acting antipsychotics; pragmatic trials; psychosis