title: Serum Caveolin-1 as a Novel Biomarker in Idiopathic Pulmonary Artery Hypertension.
abstract: Pulmonary arterial hypertension (PAH) is a rare disease but with significant morbidity and high mortality. There is no specific way to diagnose PAH. Thus, an easy used with good sensitivity and specificity biomarker of PAH is highly desirable to aid in the screening, diagnosis, and follow-up. Caveolin-1 (Cav1) is the structural protein of caveolae and is highly expressed in type I pneumocytes. Lungs tissues from idiopathic PAH (IPAH) patients showed decreased expression of Cav1 in vascular endothelial cells. Therefore, we developed a direct sandwich immunoassay for the determination of Cav1 in IAPH patient's serum. The result disclosed serum Cav1 level was significantly lower in IPAH than control groups. Using serum Cav1, 17.17 pg/mL as a cutoff value, the sensitivity was 0.59 and the specificity was 1.0. There were two major findings in our results. First, serum Cav1 might be a novel biomarker in the diagnosis of IPAH with fare sensitivity and good specificity. Second, Cav1 might be used to make differential diagnosis between COPD-PH and IPAH group.
authors.affiliation: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan ; School of Medicine, Chung Shan Medical University, Taichung, Taiwan ; School of Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Kuo-Yang
authors.initials: KY
authors.lastname: Wang
authors.affiliation: Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Mey-Fann
authors.initials: MF
authors.lastname: Lee
authors.affiliation: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan ; Department of Life Science, Tunghai University, Taichung, Taiwan.
authors.forename: Hung-Chin
authors.initials: HC
authors.lastname: Ho
authors.affiliation: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan ; Institute of Clinical Medicine, Cardiovascular Research Center, Taiwan ; Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan.
authors.forename: Kae-Woei
authors.initials: KW
authors.lastname: Liang
authors.affiliation: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan ; Department of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Liu
authors.affiliation: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Wan-Jane
authors.initials: WJ
authors.lastname: Tsai
authors.affiliation: Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan ; School of Medicine, China Medical University, Taichung, Taiwan ; Department of Life Science, Tunghai University, Taichung, Taiwan.
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Lin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D051242:Caveolin 1 / Q000097:blood*; D003937:Diagnosis, Differential; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D065627:Familial Primary Pulmonary Hypertension / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000473:pathology
chemical_list: D015415:Biomarkers; D051242:Caveolin 1