title: Serum Total Bilirubin, not Cholelithiasis, is Influenced by UGT1A1 Polymorphism, Alpha Thalassemia and β(s) Haplotype: First Report on Comparison between Arab-Indian and African β(s) Genes.
abstract: BACKGROUND
  We explored the potential relationship between steady state serum bilirubin levels and the incidence of cholelithiasis in the context of UGT1A1 gene A(TA)nTAA promoter polymorphism in Omani sickle cell anemia (SCA) patients, homozygotes for African (Benin and Bantu) and Arab-Indian β(S) haplotypes, but sharing the same microgeographical environment and comparable life style factors.
  
  
  METHODS
  136 SCA patients were retrospectively studied in whom imaging data including abdominal CT scan, MRI or Ultrasonography were routinely available. Available data on the mean steady state hematological/biochemical parameters (n=136), β(s) haplotypes(n=136), α globin gene status (n=105) and UGT1A1 genotypes (n=133) were reviewed from the respective medical records.
  
  
  RESULTS
  The mean serum total bilirubin level was significantly higher in the homozygous UGT1A1(AT)7 group as compared to UGT1A1(AT)6 group. Thus, not cholelithiasis but total serum bilirubin was influenced by UGT1A1 polymorphism in this SCA cohort.
  
  
  CONCLUSIONS
  As observed in other population groups, the UGT1A1 (AT)7 homozygosity was significantly associated with raised serum total bilirubin level, but the prevalence of gallstones in the Omani SCA patients was not associated with α thalassaemia, UGT1A1 polymorphism, or β(s) haplotypes.
authors.affiliation: Ministry of Health, Muscat, Oman & McMaster University, Canada.
authors.forename: Said Y
authors.initials: SY
authors.lastname: Alkindi
authors.affiliation: Sultan Qaboos University Hospital, Muscat, OMAN.
authors.forename: Anil
authors.initials: A
authors.lastname: Pathare
authors.affiliation: Sultan Qaboos University Hospital, Muscat, OMAN.
authors.forename: Shoaib
authors.initials: S
authors.lastname: Al Zadjali
authors.affiliation: Sultan Qaboos University Hospital, Muscat, OMAN.
authors.forename: Vinodhkumar
authors.initials: V
authors.lastname: Panjwani
authors.affiliation: Sultan Qaboos University Hospital, Muscat, OMAN.
authors.forename: Fauzia
authors.initials: F
authors.lastname: Wasim
authors.affiliation: Sultan Qaboos University Hospital, Muscat, OMAN.
authors.forename: Hammad
authors.initials: H
authors.lastname: Khan
authors.affiliation: Sultan Qaboos University Hospital, Muscat, OMAN.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Chopra
authors.affiliation: INSERM, U665, F-75015 Paris, France; Laboratoire d'Excellence GR-EX, Paris, France.
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Krishnamoorthy
authors.affiliation: Sultan Qaboos University, College of Medicine & Health Sciences, Muscat, OMAN.
authors.forename: Salam
authors.initials: S
authors.lastname: Alkindi