title: MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice.
abstract: Many studies have shown that the pathogenesis of liver injury includes oxidative stress. MicroRNA-122 may be a marker for the early diagnosis of drug-induced liver injury. However, the relationship between microRNA-122 and oxidative stress in anti-tuberculosis drug-induced liver injury remains unknown. We measured changes in tissue microRNA-122 levels and indices of oxidative stress during liver injury in mice after administration of isoniazid, a first-line anti-tuberculosis drug. We quantified microRNA-122 expression and indices of oxidative stress at 7 time points, including 1, 3, and 5 days and 1, 2, 3, and 4 weeks. The tissue microRNA-122 levels and oxidative stress significantly changed at 3 and 5 days, suggesting that isoniazid-induced liver injury reduces oxidative stress and microRNA-122 expression compared to in the control group (P < 0.05). Notably, over the time course of isoniazid-induced liver injury, mitochondrial ribosome protein S11 gene, the target of microRNA-122, began to change at 5 days (P < 0.05). The tissue microRNA-122 profile may affect oxidative stress by regulating mitochondrial ribosome protein S11 gene during isoniazid-induced liver injury, which may contribute to the response mechanisms of microRNA-122 and oxidative stress.
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: L
authors.initials: L
authors.lastname: Song
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: Z R
authors.initials: ZR
authors.lastname: Zhang
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Zhang
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: X B
authors.initials: XB
authors.lastname: Zhu
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: L
authors.initials: L
authors.lastname: He
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: L
authors.initials: L
authors.lastname: Gao
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: B
authors.initials: B
authors.lastname: Hu
authors.affiliation: Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, China.
authors.forename: F M
authors.initials: FM
authors.lastname: Feng
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D015870:Gene Expression; D007538:Isoniazid / Q000009:adverse effects; D008111:Liver Function Tests; D008297:Male; D008668:Metallothionein / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000235:genetics*; D013997:Time Factors
chemical_list: D035683:MicroRNAs; C544354:Mirn122 microRNA, mouse; D008668:Metallothionein; D007538:Isoniazid