title: Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions.
abstract: We studied the effect of melatonin and epithalon on age-related changes in proteolytic digestive enzyme activity in the pancreas and gastric mucosa of rats kept under different lighting conditions. In rats kept under standard illumination, pepsin activity and the total proteolytic activity in the stomach and pancreas increased by the age of 12 months, but then decreased. Constant and natural lighting disturbed the age dynamics of proteolytic digestive enzyme activity. Administration of melatonin and epithalon to animals exposed to constant lighting restored age dynamics of pepsin activity and little affected total proteolytic activity.
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia. artem.morozow@yandex.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Morozov
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Khizhkin
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: E B
authors.initials: EB
authors.lastname: Svechkina
authors.affiliation: Petrozavodsk State University, Petrozavodsk, Republic of Karelia.
authors.forename: I A
authors.initials: IA
authors.lastname: Vinogradova
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, St. Petersburg, Russia.|Petrozavodsk State University, Petrozavodsk, Republic of Karelia.
authors.forename: V A
authors.initials: VA
authors.lastname: Ilyukha
authors.affiliation: N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
mesh_terms: D000367:Age Factors; D000375:Aging / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D021461:Animals, Outbred Strains; D002940:Circadian Rhythm / Q000187:drug effects; D004063:Digestion / Q000187:drug effects* / Q000502:physiology; D004789:Enzyme Activation / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D008027:Light; D008029:Lighting; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D010775:Photic Stimulation; D017440:Photoperiod; D051381:Rats
chemical_list: D009842:Oligopeptides; D010447:Peptide Hydrolases; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine
keywords: aging; epithalon; illumination regimes; melatonin; proteolytic digestive enzymes