title: The Need for Core Outcome Reporting in Autologous Fat Grafting for Breast Reconstruction.
abstract: BACKGROUND
  There is growing interest in autologous fat grafting (AFG) for breast reconstruction. This systematic review examines the range of outcomes used across studies of AFG, their definitions and whether there is a need for a core outcome set to aid reporting.
  
  
  METHODS
  Following the protocol of our systematic review, a search of 20 databases (1986 to March 2014) returned 35 studies which met the inclusion criteria. These were assessed independently by two authors. Disagreements were resolved by consensus.
  
  
  RESULTS
  Of the 35 studies, 27 (77%) were case series, 5 (14.3%) were cohort studies, and 3 (8.6%) were case reports. A total of 51 different outcomes were reported. These studies each reported a median of five separate outcomes (range, 2-14), of which a median of 3 outcomes were defined (range, 0-14). A median of 2 outcomes per paper were prespecified in the study methods (range, 0-12) and a median of only 2 outcomes per paper (range, 0-12) were both defined and prespecified. The most commonly reported outcome in studies of AFG was that of "operative details," reported by 26 studies, and eight different outcome definitions were used. "Cancer recurrence" was reported by 20 studies, with the use of 10 different outcome definitions. Overall, there was a poor proportion of defined and prespecified outcomes that employed a wide range of different outcome definitions. In addition only 14/35 studies stated the number of patients lost to follow-up.
  
  
  CONCLUSIONS
  There is a need for a core outcomes set for AFG to the breast to minimise outcome and reporting bias and aid evidence synthesis. Our future research will focus in this direction, titled VOGUE or Valid Outcomes for the Grafting of AUtologous Fat to the BrEast study. We invite all those interested to get in touch with the lead author.
authors.affiliation: From the *Department of Plastic Surgery, Guy's and St. Thomas' NHS Foundation Trust; †Academic Foundation Doctor, Guy's and St. Thomas' NHS Foundation Trust, London; ‡St. Andrews Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, Essex; §Barts and the London School of Medicine and Dentistry, QMUL, London, United Kingdom; and ∥Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA.
authors.forename: Riaz A
authors.initials: RA
authors.lastname: Agha
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Fowler
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Pidgeon
authors.forename: Georgina
authors.initials: G
authors.lastname: Wellstead
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Orgill
mesh_terms: D015982:Bias; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D017063:Outcome Assessment, Health Care / Q000379:methods* / Q000592:standards; D012107:Research Design / Q000592:standards*; D050151:Subcutaneous Fat / Q000637:transplantation*; D014182:Transplantation, Autologous / Q000379:methods