title: Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment.
abstract: Myeloid derived suppressor cells (MDSCs) are a group of immature myeloid cells accumulated in most cancer patients and mouse tumor models. MDSCs suppress host immune response and concurrently promote tumor angiogenesis, thereby promote tumor growth and progression. In this review, we discuss recent progresses in expansion and activity of tumor MDSCs, and describe new findings about immunosuppressive function of different subtypes of MDSCs in cancer. We also discussed tumor angiogenic activities and pro-tumor invasion/metastatic roles of MDSCs in tumor progression.
authors.affiliation: National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Qu
authors.affiliation: National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Wang
authors.affiliation: National Cancer Institute, National Institutes of Health, Frederick, MD, USA. Electronic address: p.lin@nih.gov.
authors.forename: P Charles
authors.initials: PC
authors.lastname: Lin
mesh_terms: D049109:Cell Proliferation; D018450:Disease Progression; D006801:Humans; D008297:Male; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic; D015398:Signal Transduction; D019139:Tumor Escape; D059016:Tumor Microenvironment
keywords: M-MDSC; Myeloid-derived suppressor cells; PMN-MDSC; Tumor microenvironment; angiogenesis; immune suppression