title: Aberrant decrease of microRNA19b regulates TSLP expression and contributes to Th17 cells development in myasthenia gravis related thymomas.
abstract: Myasthenia gravis (MG) is an organ-specific autoimmune disease. The imbalance of T helper type 17 cells (Th17) plays a key role in the pathogenesis of thymomatous MG. But the regulatory mechanism for Th17 cell development in MG-related thymoma remains undefined. Here we demonstrated that thymic stromal lymphopoietin (TSLP) is significantly decreased in thymomas. We also proved that TSLP was post-trancriptionally regulated by microRNA-19b. The expression of microRNA-19b was negatively correlated with the expression of TSLP mRNA and protein in thymomas. This study indicated that the elevation of microRNA-19b suppressed TSLP expression and then influenced T cell development in thymomatous MG.
authors.affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China; Department of Neurology, The 309th Hospital of Chinese PLA, Beijing 100091, China.
authors.forename: Zhongkui
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurology, The 309th Hospital of Chinese PLA, Beijing 100091, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, The 309th Hospital of Chinese PLA, Beijing 100091, China.
authors.forename: Shengjie
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Neurology, The 309th Hospital of Chinese PLA, Beijing 100091, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurology, The 309th Hospital of Chinese PLA, Beijing 100091, China.
authors.forename: Dongning
authors.initials: D
authors.lastname: Wei
authors.affiliation: Department of Neurology, The 309th Hospital of Chinese PLA, Beijing 100091, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Xusheng
authors.initials: X
authors.lastname: Huang
mesh_terms: D000328:Adult; D015153:Blotting, Western; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009157:Myasthenia Gravis / Q000150:complications / Q000235:genetics* / Q000276:immunology; D060888:Real-Time Polymerase Chain Reaction; D058504:Th17 Cells / Q000276:immunology*; D013945:Thymoma / Q000235:genetics* / Q000276:immunology; D013953:Thymus Neoplasms / Q000235:genetics* / Q000276:immunology; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; C549214:MIRN19A microRNA, human; D035683:MicroRNAs; D000094632:Thymic Stromal Lymphopoietin
keywords: MicroRNA19b; Myasthenia gravis; TSLP; Th17 cell; Thymoma