title: Short Communication: p21/CDKN1A Expression Shows Broad Interindividual Diversity in a Subset of HIV-1 Elite Controllers.
abstract: The p21/CDKN1A protein has been described in vitro as well as in a small subset of patients as a restriction factor for HIV infection. We evaluated p21/CDKN1A mRNA expression on CD4(+) T cells from HIV-infected individuals with two outcomes (18 elite controllers and 28 viremic progressors). Our results show broad interindividual variation in this factor, which is unrelated to the patient's phenotype. Considering the gene's genetic surroundings in chromosome 6, such as HLA genotype and single nucleotide polymorphisms (SNPs), there was a positive association with carrying HLA-B2705 alleles and the rs733590 SNP. Thus, this natural variation of p21/CDKN1A alone does not appear to be a prognostic indicator of effective viral control in vivo and other factors must be considered.
authors.affiliation: 1 Foundation for Biomedical Research, University Hospital La Paz , Madrid, Spain .|2 IdiPAZ , Madrid, Spain .
authors.forename: Alicia
authors.initials: A
authors.lastname: de Pablo
authors.affiliation: 1 Foundation for Biomedical Research, University Hospital La Paz , Madrid, Spain .|2 IdiPAZ , Madrid, Spain .
authors.forename: Roberta
authors.initials: R
authors.lastname: Bogoi
authors.affiliation: 3 Foundation for Biomedical Research, Hospital Carlos III , Madrid, Spain .
authors.forename: Irene
authors.initials: I
authors.lastname: Bejarano
authors.affiliation: 4 Microbiology Department, University Hospital La Paz - Carlos III , Madrid, Spain .
authors.forename: Carlos
authors.initials: C
authors.lastname: Toro
authors.affiliation: 5 Infectious Diseases Department, University Hospital La Paz - Carlos III , Madrid, Spain .
authors.forename: Eulalia
authors.initials: E
authors.lastname: Valencia
authors.affiliation: 5 Infectious Diseases Department, University Hospital La Paz - Carlos III , Madrid, Spain .
authors.forename: Victoria
authors.initials: V
authors.lastname: Moreno
authors.affiliation: 5 Infectious Diseases Department, University Hospital La Paz - Carlos III , Madrid, Spain .
authors.forename: Luz
authors.initials: L
authors.lastname: Martín-Carbonero
authors.affiliation: 6 Microbiology Department, Hospital Virgen de la Salud , Toledo, Spain .
authors.forename: César
authors.initials: C
authors.lastname: Gómez-Hernando
authors.affiliation: 1 Foundation for Biomedical Research, University Hospital La Paz , Madrid, Spain .|2 IdiPAZ , Madrid, Spain .
authors.forename: Berta
authors.initials: B
authors.lastname: Rodés
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000096:biosynthesis*; D018450:Disease Progression; D015870:Gene Expression; D020869:Gene Expression Profiling; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D015497:HIV-1 / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21