title: C-REACTIVE PROTEIN IN DIABETIC PATIENTS BEFORE GASTRIC BYPASS AS A POSSIBLE MARKER FOR POSTOPERATIVE COMPLICATION.
abstract: BACKGROUND
  Obesity and type 2 diabetes mellitus are associated to inflammatory state, which can be set off by the adipose tissue, once it is a metabolically active organ that can cause a chronic mild inflammatory state.
  
  
  OBJECTIVE
  To evaluate the correlation between preoperative C-reactive protein and postoperative complications risk in obese patients (grades II and III) after Roux-en-Y gastric bypass, with and without type 2 diabetes mellitus.
  
  
  METHODS
  Between 2008 and 2013 were analysed 209 patients (107 with diabetes), presenting body mass index >40 kg/m2 or >35 kg/m2 with comorbidities. During the postoperative period, two groups were evaluated: with and without complications. Preoperative ultra-sensitive C-reactive protein was measured by immunonephelometry method.
  
  
  RESULTS
  Complications occurred in seven patients (pulmonary thromboembolism, fistula, two cases of suture leak, pancreatitis, evisceration and upper digestive hemorrhage). No statistical significance was found regarding lipid profile and C-reactive protein between patients with and without type 2 diabetes mellitus. When compared to each other, both groups (with and without complications) presented with statistical significance regarding C-reactive protein level (7,2 mg/dl vs 3,7 mg/dl, p=0,016) and had similar weight loss percentage after 3, 6 and 12 months follow-up.
  
  
  CONCLUSIONS
  Preoperative C-reactive protein serum level was higher in the group which presented complications after Roux-en-Y gastric bypass when compared to the group without postoperative complications.
authors.affiliation: Oswaldo Cruz Hospital, Faculty of Medical Sciences of Pernambuco, Brazil.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Lins
authors.affiliation: Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Josemberg M
authors.initials: JM
authors.lastname: Campos
authors.affiliation: Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Patrícia S
authors.initials: PS
authors.lastname: de Paula
authors.affiliation: Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Manoel
authors.initials: M
authors.lastname: Galvão-Neto
authors.affiliation: Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pachu
authors.affiliation: Oswaldo Cruz Hospital, Faculty of Medical Sciences of Pernambuco, Brazil.
authors.forename: Ney
authors.initials: N
authors.lastname: Cavalcanti
authors.affiliation: Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Álvaro A B
authors.initials: ÁA
authors.lastname: Ferraz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology*; D011300:Preoperative Care; D012189:Retrospective Studies; D018570:Risk Assessment
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein