title: Advances in Peptide-based DNA/RNA-Intercalators.
abstract: Interactions between DNA/RNA and huge variety of peptides are quite common in nature, controlling vast number of processes. Also, there are several naturally occurring small molecules which contain peptide and DNA intercalator in structure, whereby their biological activity is based on synergistic interactions of both components; for instance bis-intercalator echinomycin. Versatility of synthetic approaches to short peptides allowed their usage as simple recognition units within the DNA or RNA grooves or as backbone carriers for variety of bioactive substituents attached to amino acid side chains, one of very popular examples being PNAs. Such peptide-backbones were also used for synthesis of novel intercalators and poly-intercalators, many of them showing intriguing novel DNA/RNA interacting properties.
authors.forename: Josipa
authors.initials: J
authors.lastname: Matić
authors.forename: Lidija-Marija
authors.initials: LM
authors.lastname: Tumir
authors.forename: Marijana Radić
authors.initials: MR
authors.lastname: Stojković
authors.affiliation: Laboratory for Study of Interactions of Biomacromolecules, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia. pianta@irb.hr.
authors.forename: Ivo
authors.initials: I
authors.lastname: Piantanida
mesh_terms: D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D015335:Molecular Probes / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D007364:Intercalating Agents; D015335:Molecular Probes; D010455:Peptides; D012313:RNA; D004247:DNA