title: Tweaking Transcription to Stop AML Cell Growth.
abstract: A new compound with anti-leukemia activity perturbs gene transcription by modulating super-enhancer activity.
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D011083:Polycyclic Compounds / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D011083:Polycyclic Compounds; D047428:Protein Kinase Inhibitors; C531521:cortistatin A; D018844:Cyclin-Dependent Kinases