title: Multi-walled carbon nanotubes increase anxiety levels in rats and reduce exploratory activity in the open field test.
abstract: The results of the first study on the effects of multi-walled carbon nanotubes (MWNTs) on the exploratory activity and the emotional state in laboratory rats assessed by the open field test are reported. During three or ten days, rats received 8-10 nm MWNTs added to their food at a dose of 500 mg/kg. It was demonstrated that, in the group of rats which were fed with MWNTs, the integrated anxiety level index began to increase as early as the third day of the experiment; on the tenth day, it appeared to be twice increased. It was also demonstrated that MWNTs decreased the integrated exploratory activity index nearly twofold on the third day and nearly fourfold on the tenth day.
authors.affiliation: Amur State Medical Academy, Blagoveshchensk, 675000, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Sayapina
authors.affiliation: Amur State Medical Academy, Blagoveshchensk, 675000, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Batalova
authors.affiliation: Far East Federal University, Vladivostok, 690001, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Chaika
authors.affiliation: Far East Scientific Center for the Physiology and Pathology of Respiration, Blagoveshchensk, 675000, Russia.
authors.forename: V L
authors.initials: VL
authors.lastname: Kuznetsov
authors.affiliation: Far East Federal University, Vladivostok, 690001, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Sergievich
authors.affiliation: Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia. droopy@mail.ru.
authors.forename: V P
authors.initials: VP
authors.lastname: Kolosov
authors.affiliation: Amur State Medical Academy, Blagoveshchensk, 675000, Russia.
authors.forename: Yu M
authors.initials: YM
authors.lastname: Perel'man
authors.affiliation: Far East Federal University, Vladivostok, 690001, Russia.
authors.forename: K S
authors.initials: KS
authors.lastname: Golokhvast
mesh_terms: D000818:Animals; D001007:Anxiety / Q000209:etiology*; D005106:Exploratory Behavior / Q000187:drug effects*; D037742:Nanotubes, Carbon / Q000009:adverse effects*; D051381:Rats
chemical_list: D037742:Nanotubes, Carbon