title: Association between IL2/IL21 and SH2B3 polymorphisms and risk of celiac disease: a meta-analysis.
abstract: Celiac disease (CD) is a common autoimmune disorder characterized by heightened immunological response to ingested gluten. Certain gene polymorphisms of IL2/IL21 (rs6822844 and rs6840978) and SH2B3 (rs3184504) may influence susceptibility to CD, although the effects remain unclear. We performed a meta-analysis of the associations between rs6822844, rs6840978, and rs3184504 polymorphisms and CD risk. PubMed, EMBASE, and the China National Knowledge Infrastructure were searched. ORs and 95%CIs of each single nucleotide polymorphism (SNP) were estimated using the fixed-effect model if I(2) < 50% in the test of heterogeneity; otherwise, the random-effect model was used. Our meta-analysis included 12,986 CD cases and 28,733 controls from 16 independent samples, and the analysis of each SNP contained a subset of the total. We found that the minor allele T of both rs6822844 (T vs G, OR = 0.72, 95%CI = 0.67-0.78, P < 0.001) and rs6840978 (T vs C, OR = 0.76, 95%CI = 0.71-0.83, P < 0.001) in IL2/IL21 significantly decreased the risk of CD. However, the minor allele A of rs3184504 (A vs G, OR = 1.18, 95%CI = 1.12-1.24, P < 0.001) in SH2B3 significantly increased CD susceptibility. The estimated lambda values were 0.49, 0.50, and 0.53 for rs6822844, rs6840978, and rs3184504, respectively, suggesting that a co-dominant model of genotype effect was most appropriate for the three SNPs. Our results support associations between the three SNPs and CD and provide a strong argument for further research.
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: C C
authors.initials: CC
authors.lastname: Guo
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: W H
authors.initials: WH
authors.lastname: Huang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: F
authors.initials: F
authors.lastname: Dong
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Jing
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: X G
authors.initials: XG
authors.lastname: Ye
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: D
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: M L
authors.initials: ML
authors.lastname: Ou
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: B H
authors.initials: BH
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: W K
authors.initials: WK
authors.lastname: Liang
authors.affiliation: Department of Parasitology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China jcxphd@gmail.com.
authors.forename: C X
authors.initials: CX
authors.lastname: Jing
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000483:Alleles; D016022:Case-Control Studies; D002446:Celiac Disease / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D007378:Interleukins / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D017594:Publication Bias; D012306:Risk; D000098546:Interleukin-21
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D007376:Interleukin-2; D007378:Interleukins; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C490778:SH2B3 protein, human; D000098546:Interleukin-21