title: Lack of predictive power of plasma lipids or lipoproteins for gestational diabetes mellitus in Japanese women.
abstract: OBJECTIVE
  To determine the diagnostic potential of plasma lipids and apolipoproteins in gestational diabetes mellitus (GDM), we carried out a retrospective cohort study of 1,161 Japanese women at 20-28 weeks of gestation who underwent a glucose challenge test (GCT).
  
  
  METHODS
  A total of 1,161 Japanese women at 20-28 weeks of gestation underwent a GCT. Participants with a positive test (GCT[+]) underwent a subsequent oral glucose tolerance test. Clinical and biochemical parameters were determined and quantification of apolipoproteins (Apo), including ApoB, ApoB48, ApoA-I and ApoC-III, was carried out.
  
  
  RESULTS
  The prevalence of GCT(+; with a 130 mg/dL glucose cut-off) and GDM was 20% and 4%, respectively. There was a trend for increased triglycerides and ApoC-III in GDM(+) participants. However, the difference in plasma triglycerides, ApoC-III or ApoB48 did not reach statistical significance between GDM(+) and GDM(-) women. Values of 1-h glucose (P < 0.001) and fasting glucose (P = 0.002) were significant risk factors for GDM.
  
  
  CONCLUSIONS
  Prediction of GDM using only the ApoC-III value is not easy, although triglycerides and ApoC-III were higher in the GDM(+) group. The present findings show no significant difference in plasma lipid levels between women diagnosed with GDM and those with normal glucose tolerance.
authors.affiliation: Department of Diabetes and Endocrinology, Japanese Red Cross Medical Center Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iimura
authors.affiliation: Department of Cancer Genomics, Cancer Institute for JFCR Tokyo, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Matsuura
authors.affiliation: Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa Ottawa, ON, Canada.
authors.forename: Zemin
authors.initials: Z
authors.lastname: Yao
authors.affiliation: Fujirebio Inc. Tokyo, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Ito
authors.affiliation: Department of Clinical Pathology, Japanese Red Cross Medical Center Tokyo, Japan.
authors.forename: Mutsunori
authors.initials: M
authors.lastname: Fujiwara
authors.affiliation: Department of Diabetes and Endocrinology, Japanese Red Cross Medical Center Tokyo, Japan.
authors.forename: Michiyasu
authors.initials: M
authors.lastname: Yoshitsugu
authors.affiliation: Department of Obstetrics and Gynecology, Japanese Red Cross Medical Center Tokyo, Japan.
authors.forename: Akito
authors.initials: A
authors.lastname: Miyauchi
authors.affiliation: Department of Diabetes and Endocrinology, Japanese Red Cross Medical Center Tokyo, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Hiyoshi
keywords: Apolipoprotein C-III; Gestational diabetes mellitus; Glucose challenge test