title: Castleman Disease. A Report of Six Cases.
abstract: OBJECTIVE
  Castleman's disease is a rare disorder situated at the boundary between reactive and neoplastic conditions. The pathogenesis is a subject of debate and the limited number of cases renders the study of the disease difficult. In our paper we present a series of six cases of Castleman disease with emphasis on the clinical presentation, pathology examination and the use of immunohistochemistry in the final diagnosis of the cases.
  
  
  METHODS
  The classification of the disease was based on clinical, imaging and pathological assessment. Specimens were obtained by surgical excision and were routinely processed for the pathology examination.
  
  
  RESULTS
  All cases were unicentric disease. Two cases were locally extensive. The clinical symptoms were related mostly to compression effects. Five case were of the hyaline-vascular type and one was included in the plasma cell variant. One case showed angiomyoid differentiation.
  
  
  CONCLUSIONS
  We strongly believe that by understanding the pathogenesis of the precursor lesions we will gain better understanding of the pathways that lead to neoplasia and that Castleman disesase is a very interesting "natural experiment" illustrating the progression from chronic antigen stimulation to reactive lymphoid hyperplasia and finally to overt lymphoid neoplasia.
authors.affiliation: Department of Pathology, "Prof. Dr. I. Chiricuta" Oncology Institute, Cluj-Napoca, Romania.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Fetica
authors.affiliation: Department of Pathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Pop
authors.affiliation: Department of Surgery, "Prof. Dr. I. Chiricuta" Oncology Institute, Cluj-Napoca, Romania ; Department of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Cosmin
authors.initials: C
authors.lastname: Lisencu
authors.affiliation: Department of Surgery, "Prof. Dr. I. Chiricuta" Oncology Institute, Cluj-Napoca, Romania ; Department of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Alin Cristian
authors.initials: AC
authors.lastname: Rancea
authors.affiliation: Department of Surgery Polisano Clinic Sibiu, Romania.
authors.forename: Aurel
authors.initials: A
authors.lastname: Coman
authors.affiliation: Department of Hematology, "Prof. Dr. I. Chiricuta" Oncology Institute, Cluj-Napoca, Romania ; Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Andrei
authors.initials: A
authors.lastname: Cucuianu
authors.affiliation: Department of Hematology, "Prof. Dr. I. Chiricuta" Oncology Institute, Cluj-Napoca, Romania ; Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Ljubomir
authors.initials: L
authors.lastname: Petrov
keywords: Giant lymph node hyperplasia; Herpesvirus 8; Human; Immunohistochemistry; Interleukin-6