title: Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease.
abstract: The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence or the cause of IBD is currently not fully understood. The pathogenesis of IBD is believed to be a complex interaction between genetic predisposition, the immune system and environmental factors. In the recent years, metagenomic studies of the human microbiome have provided useful data that are helping to assemble the IBD puzzle. In this review, we summarize and discuss current knowledge on the composition of the intestinal microbiota in IBD, host-microbe interactions and therapeutic possibilities using bacteria in IBD. Moreover, an outlook on the possible contribution of bacteriophages in the pathogenesis and therapy of IBD is provided.
authors.affiliation: Janka Babickova, Roman Gardlik, Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.
authors.forename: Janka
authors.initials: J
authors.lastname: Babickova
authors.affiliation: Janka Babickova, Roman Gardlik, Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.
authors.forename: Roman
authors.initials: R
authors.lastname: Gardlik
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects / Q000821:virology*; D001435:Bacteriophages; D064806:Dysbiosis; D000069467:Fecal Microbiota Transplantation; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D054884:Host-Pathogen Interactions; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology* / Q000628:therapy; D007422:Intestines / Q000187:drug effects / Q000276:immunology / Q000382:microbiology*; D019936:Probiotics / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents
keywords: Bacterial therapy; Bacteriophages; Gut; Inflammatory bowel disease; Microbiota