title: [Relationship between dietary vitamin C and Type 2 diabetes].
abstract: OBJECTIVE
  To examine the correlation between dietary vitamin C intake and Type 2 diabetes.
  
  
  METHODS
  A total of 5 168 participants from Xiangya Hospital, Central South University were randomly selected. According to the vitamin C intake, the participants were divided into 5 groups: a Q1 group (n=1 033), a Q2 group (n=1 034), a Q3 group (n=1 034), a Q4 group (n=1 034) and a Q5 group (n=1 033). They were also divided into a Type 2 diabetes group (n=502) and a non-diabetes group (n=4 666). The height, weight, and blood pressure were measured, and vitamin C intake and other dairy consumption were evaluated using a food frequency questionnaire and fasting plasma glucose (FPG). The analysis of variance (ANOVA), Chi-square test, Mann-Whitney U test and logistic regression model were used to analyze the relationship between dietary vitamin C and Type 2 diabetes.
  
  
  RESULTS
  The univariate analysis showed that there were significant differences in the vitamin C consumption in energy intake, activity level, dietary fiber intake, nutritional supplementation status, drinking or not drinking, education level among the different vitamin C intake groups (all P<0.05). There were also significant differences in age, sex, body mass index (BMI), smoking status and vitamin C intake between the Type 2 diabetes group and the non-diabetes group (all P<0.05). After the adjustment for age, gender, hypertension, energy intake or smoking status, the multiple logistic regression model found that the multivariable adjusted OR was 0.610 (95% CI 0.428-0.870) for  the highest level of vitamin C intake (>154.78 mg/d) in comparison with the lowest level (≤ 63.26 mg/d). The results suggested that the vitamin C intake was inversely associated with the Type 2 diabetes (r=-0.029, P<0.05).
  
  
  CONCLUSIONS
  There is a significant negative correlation between the dietary vitamin C intake and the risk of Type 2 diabetes.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.
authors.forename: Xinliang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.
authors.forename: Tubao
authors.initials: T
authors.lastname: Yang
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D004032:Diet; D019587:Dietary Supplements; D006801:Humans; D016015:Logistic Models; D009752:Nutritional Status; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D014815:Vitamins; D001205:Ascorbic Acid