title: Glucocorticoid-Related Regulation of LPO in Brain Cortex during Anxiogenic Stress.
abstract: Under conditions of periodic exposures to anxiogenic stress, intensification of LPO in the brain cortex is a glucocorticoid-dependent process. Glucocorticoid receptor antagonist RU38486 prevented increase in monoamine oxidase B activity and content of LPO products of in brain cortex typical of anxiogenic stress. Normalization of LPO intensity under the effect of glucocorticoid receptor antagonist was associated with the correction of stress-induced disturbances.
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia. vadimed@yandex.ru.
authors.forename: V E
authors.initials: VE
authors.lastname: Tseilikman
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Sinitskii
authors.affiliation: South Ural State University, Chelyabinsk, Russia.
authors.forename: O B
authors.initials: OB
authors.lastname: Tseilikman
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: R V
authors.initials: RV
authors.lastname: Deev
authors.affiliation: South Ural State University, Chelyabinsk, Russia.
authors.forename: M S
authors.initials: MS
authors.lastname: Lapshin
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Kozochkin
mesh_terms: D000818:Animals; D001007:Anxiety / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D005938:Glucocorticoids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D015735:Mifepristone / Q000494:pharmacology; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D015735:Mifepristone; D008995:Monoamine Oxidase
keywords: RU38486; glucocorticoids; lipid peroxidation; monoamine oxidase B; stress