title: Natural products as a source of drug leads to overcome drug resistance.
abstract: Novel antibacterials may be found that can enhance the pipeline of therapeutics capable of overcoming antibiotic resistance by a return to exploration of natural products. Such novel products may be derived from both standard and previously uncultivable sources, and enriched by expression of previously unseen antibiotics predicted by genome mining of productive bacterial genera. Hypersensitive whole cell phenotypic screens can be used to detect novel secondary metabolites from both standard and newly uncovered sources.
authors.affiliation: LL Silver Consulting, LLC, 955 South Springfield Avenue, Unit C403, Springfield, NJ 07081, USA.
authors.forename: Lynn L
authors.initials: LL
authors.lastname: Silver
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D024881:Drug Resistance, Bacterial; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products
keywords: genome mining; hypersensitive screens; natural products; phenotypic screening