title: Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children.
abstract: OBJECTIVE
  The clinical interpretation of children sensitized to allergens is challenging, particularly in children with food allergies. We aimed to examine clinical differences between children with monosensitization and those with polysensitization to common food allergens and to determine risk factors for polysensitization in young children <10 years of age with immediate-type food allergies.
  
  
  METHODS
  The study included children <10 years of age with signs and symptoms indicative of immediate-type food allergies. Serum total IgE level was measured, and ImmunoCAP analysis for food allergens was performed.
  
  
  RESULTS
  The mean age of the study subjects was 1.6±1.6 years (75 boys and 51 girls). Thirty-eight children (30.2%) were monosensitized and 88 children (69.8%) were polysensitized. Multivariate logistic regression analysis showed that the development of polysensitization to common food allergens was positively associated with a parental history of allergic rhinitis (adjusted odds ratio [aOR], 6.28; 95% confidence interval [CI], 1.78-22.13; P=0.004), season of birth (summer/fall) (aOR, 3.10; 95% CI, 1.10-8.79; P=0.033), and exclusive breastfeeding in the first 6 months of age (aOR, 3.51; 95% CI, 1.20-10.25; P=0.022).
  
  
  CONCLUSIONS
  We found significant clinical differences between children with monosensitization and those with polysensitization to common food allergens and identified risk factors for the development of polysensitization in young children with immediate-type food allergies. Clinicians should consider these clinical risk factors when evaluating, counseling, treating, and monitoring young children with food allergies.
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea.
authors.forename: Na Yeon
authors.initials: NY
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea.
authors.forename: Ga Ram
authors.initials: GR
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea.
authors.forename: Joon Hwan
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
authors.forename: Ji Hyeon
authors.initials: JH
authors.lastname: Baek
authors.affiliation: Department of Pediatrics, Myongji Hospital, Goyang, Korea.
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Yoon
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea. ; Department of Pediatrics, CHA University School of Medicine, Pocheon, Korea.
authors.forename: Hye Mi
authors.initials: HM
authors.lastname: Jee
authors.affiliation: Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Hye Sung
authors.initials: HS
authors.lastname: Baek
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea. ; Department of Pediatrics, CHA University School of Medicine, Pocheon, Korea.
authors.forename: Yong Ho
authors.initials: YH
authors.lastname: Jung
authors.affiliation: Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Department of Pediatrics, CHA University School of Medicine, Pocheon, Korea. ; Department of Pediatrics, CHA Gangnam Medical Center, Seoul, Korea.
authors.forename: Ki Eun
authors.initials: KE
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, CHA University School of Medicine, Pocheon, Korea. ; Department of Pediatrics, CHA Gangnam Medical Center, Seoul, Korea. ; Department of Medicine, The Graduate School, Yonsei University, Seoul, Korea.
authors.forename: Youn Ho
authors.initials: YH
authors.lastname: Shin
authors.affiliation: Department of Pediatrics, Seoul Medical Center, Seoul, Korea.
authors.forename: Hye Yung
authors.initials: HY
authors.lastname: Yum
authors.affiliation: Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea. ; Department of Pediatrics, CHA University School of Medicine, Pocheon, Korea.
authors.forename: Man Yong
authors.initials: MY
authors.lastname: Han
authors.affiliation: Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyu-Earn
authors.initials: KE
authors.lastname: Kim
keywords: Child; Food hypersensitivity; Sensitization