title: Oncoproteomics: Trials and tribulations.
abstract: Oncoproteomics is the study of cancer-associated proteins and their interactions using proteomic technologies. It is expected to play a crucial role in the detection and surveillance of cancer, as well as in the development of personalized medicine for oncology. In this review, we will outline the current status, advantages, and limitations of oncoproteomics. Further, we will discuss available strategies arising from a better understanding of oncoproteomics, including integrated omics approaches, to overcome current problems in the discovery and validation of biomarkers, identification of novel drug targets, and management of personalized medicine.
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, P. R. China.|Department of Neurology, The Affiliated Hospital of Hainan Medical College, Haikou, Hainan, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Neurology, The Affiliated Hospital of Hainan Medical College, Haikou, Hainan, P. R. China.
authors.forename: Qifu
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Biomedical, Chengdu Medical College, Chengdu, Sichuan Province, P. R. China.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, P. R. China.
authors.forename: Canhua
authors.initials: C
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, P. R. China.|Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
authors.forename: Edouard C
authors.initials: EC
authors.lastname: Nice
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D058990:Molecular Targeted Therapy; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D057285:Precision Medicine; D020543:Proteome / Q000235:genetics* / Q000378:metabolism; D040901:Proteomics / Q000295:instrumentation / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D020543:Proteome
keywords: Biomarkers; Cancer; Mass spectrometry; Oncoproteomics; Personalized medicine; Protein micropurification