title: Multiple myeloma involving mandible: In an elderly female.
abstract: Multiple myeloma (MM) is a malignancy of plasma cell origin. It often has a multicentric origin within the bone. It makes about 1% of all malignancies and 15% of all hematologic malignancies. There is a monoclonal proliferation of abnormal plasma cells in this disease that arise from a single malignant precursor that has undergone uncontrolled mitotic division. These cells in turn produce one type of immunoglobulin light chain, either kappa or lambda. Unifocal, monoclonal proliferation of plasma cells is called plasmacytoma. Hereby, we present a case of a 65-year-old female patient who presented with a swelling of the mandible. The uniform sheets of plasma cells in the histopathology punched out radiolucencies in skull radiograph and the blood picture of anemia and hypercalcemia, confirmed the case as MM.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Adhiparasakthi Dental College, Melmaruvathur, Tamil Nadu, India.
authors.forename: C
authors.initials: C
authors.lastname: Sreeja
authors.affiliation: Department of Oral and Maxillofacial Surgery, Adhiparasakthi Dental College, Melmaruvathur, Tamil Nadu, India.
authors.forename: B
authors.initials: B
authors.lastname: Vijayabanu
authors.affiliation: Department of Oral and Maxillofacial Pathology, Adhiparasakthi Dental College, Melmaruvathur, Tamil Nadu, India.
authors.forename: D
authors.initials: D
authors.lastname: Vijayalakshmi
authors.affiliation: Department of Oral and Maxillofacial Pathology, Adhiparasakthi Dental College, Melmaruvathur, Tamil Nadu, India.
authors.forename: M
authors.initials: M
authors.lastname: Devi
authors.affiliation: Department of Oral and Maxillofacial Pathology, Adhiparasakthi Dental College, Melmaruvathur, Tamil Nadu, India.
authors.forename: K
authors.initials: K
authors.lastname: Ramakrishnan
authors.affiliation: Department of Oral and Maxillofacial Pathology, Adhiparasakthi Dental College, Melmaruvathur, Tamil Nadu, India.
authors.forename: K
authors.initials: K
authors.lastname: Dhivya
keywords: Hypercalcemia; immunoglobulin; multiple myeloma; radiolucencies