title: [The expression of Endophilin II and VEGF-C in human laryngeal cancer and connection with clinical treatment].
abstract: OBJECTIVE
  To study the expression of Endophilin II and VEGF-C in human Laryngeal cancer and its relationship with the clinical treatment effect.
  
  
  METHODS
  The expression and distribution of Endophilin II and VEGF-C protein were checked in 47 patients with laryngeal carcinoma in our hospital in 2006-09-2009-10 and 23 samples of normal tissues around the cancer by immunohistochemical staining SP method. After an appropriate surgical treatment, patients accepted a 5-year followup to evaluate their recurrence situation and 5-year survival rate.
  
  
  RESULTS
  Immunohistochemistry showed that Endophilin II protein was strongly positive expressed in normal tissues around the cancer (positive rate 82.61%). And the expression level was dependent on the lymph metastasis, T stage and lymph invasion (P < 0.05). Patients with positive Endophilin II expression had a higher survival rate and better recurrence situation. Expression of VEGF-C was significantly higher in laryngeal carcinoma than in normal tissue around the cancer (positive rate 51.06% and 13.04%). the expression level was dependent on the lymph metastasis and lymph invasion (P < 0.05), and negatively correlated with recurrence and 5-year survival rate.
  
  
  CONCLUSIONS
  Endophilin II and VEGF-C may involve in laryngeal cancer, and the expression of Endophilin II and VEGF-C has a positive correlation with pathological features and lymph metastasis, and both are related with recurrence and 5-year survival rate. So these two proteins are likely to be a potential target for diagnosis and treatment of laryngeal cancer.
authors.forename: Zhong Pu
authors.initials: ZP
authors.lastname: Yin
authors.forename: Chen
authors.initials: C
authors.lastname: Yang
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local; D015996:Survival Rate; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C467486:VEGFC protein, human; D042582:Vascular Endothelial Growth Factor C