title: Synthesis of Sterically Protected Xanthene Dyes with Bulky Groups at C-3' and C-7'.
abstract: Substitution of the xanthene scaffold with bulky groups at C-3' and C-7' is expected to protect the electrophilic central methine carbon against nucleophilic attack and inhibit stacking. However, such structures are not readily prepared via traditional xanthene syntheses. We have devised an alternative and convenient synthesis to enable facile preparation of this subset of xanthene dyes under mild conditions and in good yields.
authors.affiliation: State Key Laboratory of Bioreactor Engineering, and †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Zuhai
authors.initials: Z
authors.lastname: Lei
authors.affiliation: State Key Laboratory of Bioreactor Engineering, and †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Xinran
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioreactor Engineering, and †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioreactor Engineering, and †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Bioreactor Engineering, and †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Bioreactor Engineering, and †Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Youjun
authors.initials: Y
authors.lastname: Yang