title: A Betabaculovirus-Encoded gp64 Homolog Codes for a Functional Envelope Fusion Protein.
abstract: The GP64 envelope fusion protein is a hallmark of group I alphabaculoviruses. However, the Diatraea saccharalis granulovirus genome sequence revealed the first betabaculovirus species harboring a gp64 homolog (disa118). In this work, we have shown that this homolog encodes a functional envelope fusion protein and could enable the infection and fusogenic abilities of a gp64-null prototype baculovirus. Therefore, GP64 may complement or may be in the process of replacing F protein activity in this virus lineage.
authors.affiliation: Laboratory of Baculovirus, Cell Biology Department, University of Brasilia, Brasilia, DF, Brazil Division of Biology, Kansas State University, Manhattan, Kansas, USA.
authors.forename: Daniel M P
authors.initials: DM
authors.lastname: Ardisson-Araújo
authors.affiliation: Laboratory of Baculovirus, Cell Biology Department, University of Brasilia, Brasilia, DF, Brazil.
authors.forename: Fernando L
authors.initials: FL
authors.lastname: Melo
authors.affiliation: Division of Biology, Kansas State University, Manhattan, Kansas, USA.
authors.forename: Rollie J
authors.initials: RJ
authors.lastname: Clem
authors.affiliation: Laboratory of Molecular Biology and Virology, Biological Science and Health Center, Mackenzie Presbyterian University, Sao Paulo, SP, Brazil.
authors.forename: José L C
authors.initials: JL
authors.lastname: Wolff
authors.affiliation: Laboratory of Baculovirus, Cell Biology Department, University of Brasilia, Brasilia, DF, Brazil bergmann@unb.br.
authors.forename: Bergmann M
authors.initials: BM
authors.lastname: Ribeiro
mesh_terms: D000818:Animals; D005816:Genetic Complementation Test; D025722:Granulovirus / Q000235:genetics / Q000502:physiology*; D007915:Lepidoptera / Q000821:virology; D014760:Viral Fusion Proteins / Q000235:genetics* / Q000378:metabolism*; D053586:Virus Internalization
chemical_list: D014760:Viral Fusion Proteins