title: Helicoid peripapillary chorioretinal degeneration complicated by choroidal neovascularization.
abstract: OBJECTIVE
  Helicoid peripapillary chorioretinal degeneration (HPCD) is a hereditary disease of the fundus that is characterized by atrophic chorioretinal areas that appear early in life and expand gradually from the optic disc towards the macula and the periphery.
  
  
  METHODS
  We describe the case of an elderly man with a known diagnosis of HPCD who developed choroidal neovascular membrane (CNV) in both eyes during the course of the disease.
  
  
  RESULTS
  The patient was treated with intravitreal injection of ranibizumab, to which he had excellent response. The CNV subsided with 2 injections in the right eye and 1 in the left. Two years after the initial diagnosis of CNV in the right eye, visual acuity was 5/10 OD and 9/10 OS.
  
  
  CONCLUSIONS
  Helicoid peripapillary chorioretinal degeneration is rarely complicated by CNV as the fundus lacks the trigger factors that would sustain this process. Although rare, HPCD complicated by CNV can be seen bilaterally, but responds well to few ranibizumab injections.
authors.affiliation: Department of Ophthalmology, University Hospital of Evros, Alexandroupolis - Greece.
authors.forename: Magdalini
authors.initials: M
authors.lastname: Triantafylla
authors.affiliation: Department of Ophthalmology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Geneva - Switzerland.
authors.forename: Georgios D
authors.initials: GD
authors.lastname: Panos
authors.affiliation: Department of Ophthalmology, University Hospital of Evros, Alexandroupolis - Greece.
authors.forename: Doukas
authors.initials: D
authors.lastname: Dardabounis
authors.affiliation: Department of Ophthalmology, University Hospital of Evros, Alexandroupolis - Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Nanos
authors.affiliation: Department of Ophthalmology, University Hospital of Evros, Alexandroupolis - Greece.
authors.forename: Aristeidis
authors.initials: A
authors.lastname: Konstantinidis
mesh_terms: D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003317:Corneal Dystrophies, Hereditary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D000069579:Ranibizumab / Q000627:therapeutic use; D012162:Retinal Degeneration / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity / Q000502:physiology
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000069579:Ranibizumab