title: Chronic Intermittent Hypoxia and Blood Pressure: Is There Risk for Hypertension in Healthy Individuals?
abstract: OBJECTIVE
  The aim of the current study was to assess a year-long impact of chronic intermittent exposure to hypoxia on blood pressure (BP) in healthy working middle-aged adults.
  
  
  METHODS
  Data from pre-employment and annual screening of high-altitude mining company (elevation 4000 meters above sea level) were obtained for 472 workers aged 34.1 ± 7.8 years, working 2-week shifts, followed by 2 weeks of rest at low altitude (cumulative exposure 6 months). Overall systolic, diastolic BP change (ΔBP) were calculated, and tested in multivariate regression models in the entire group, as well as in different strata of BP.
  
  
  RESULTS
  Baseline systolic BP reduced from 123.2 ± 11.3 to 116.3 ± 13.1 mmHg (ΔBP 6.8 mmHg), diastolic BP from 76.7 ± 8.4 to 74.9 ± 8.4 mmHg (ΔBP -1.7 mmHg) (p < 0.001), both measured at low altitude before and after one year of exposure to chronic intermittent hypoxia. The greater the baseline BP, the more pronounced was BP decrease. In the most prevalent combined group of normal and high normal BP, both systolic and diastolic BP reduced after one year of high altitude exposure (p < 0.01). In multivariate adjusted models, none of exposures of interest were associated with ΔBP.
  
  
  CONCLUSIONS
  One-year intermittent exposure to hypobaric hypoxia in new hires for high-altitude mining company was not associated with BP increase.
authors.affiliation: 1 Public Association "Lung Health ," Bishkek, Kyrgyzstan .
authors.forename: Denis
authors.initials: D
authors.lastname: Vinnikov
authors.affiliation: 2 Kyrgyz State Medical Academy , Bishkek, Kyrgyzstan .
authors.forename: Nurlan
authors.initials: N
authors.lastname: Brimkulov
authors.affiliation: 3 Kumtor Gold Company , Bishkek, Kyrgyzstan .
authors.forename: Viktor
authors.initials: V
authors.lastname: Krasotski
mesh_terms: D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000150:complications* / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data; D008906:Mining; D015999:Multivariate Analysis; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D016272:Occupational Health / Q000706:statistics & numerical data; D012044:Regression Analysis; D012307:Risk Factors
keywords: blood pressure; hypoxia; intermittent hypoxia; occupational; screening