title: Investigation of activating and inhibitory killer cell immunoglobulin-like receptors and their putative ligands in type 1 diabetes (T1D).
abstract: Genetic and environmental factors play important roles in predisposing an individual to the development of type 1 diabetes (T1D). Several studies have investigated the role of killer cell immunoglobulin-like receptors (KIRs) and their HLA-class I ligands in susceptibility to T1D development, but only some of these studies have demonstrated an association. KIRs and their corresponding HLA class I ligands were investigated in Saudi patients with T1D compared with healthy controls. No significant differences in KIR gene distribution were observed between T1D patients and healthy controls. However, the homozygous C1/C1 ligand was considered a risk factor in predisposing individuals to T1D, whereas C2/C2 and HLA-Bw4 were considered protective factors against T1D. KIR2DL2/2DS2-C1C1 and KIR2DL3-C1C1 were significantly associated with T1D, and KIR2DS1-C2C2 and KIR2DL1-C2C2 were significantly less frequent in T1D patients. Stratification of KIR-HLA class I ligands in terms of the absence/presence of specific genotypes has different indications for susceptibility to T1D.
authors.affiliation: King Fahad Medical City, Riyadh 11525, Saudi Arabia. Electronic address: awadelsid@yahoo.om.
authors.forename: Awad E
authors.initials: AE
authors.lastname: Osman
authors.affiliation: King Fahad Medical City, Riyadh 11525, Saudi Arabia.
authors.forename: Nezar
authors.initials: N
authors.lastname: Eltayeb-ELSheikh
authors.affiliation: King Fahad Medical City, Riyadh 11525, Saudi Arabia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mubasher
authors.affiliation: King Fahad Medical City, Riyadh 11525, Saudi Arabia.
authors.forename: Hanan
authors.initials: H
authors.lastname: Al Harthi
authors.affiliation: King Fahad Medical City, Riyadh 11525, Saudi Arabia.
authors.forename: Sahar
authors.initials: S
authors.lastname: Alharbi
authors.affiliation: King Fahad Medical City, Riyadh 11525, Saudi Arabia.
authors.forename: Muaawia A
authors.initials: MA
authors.lastname: Hamza
authors.affiliation: Mafraq Hospital and Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
authors.forename: Gehad
authors.initials: G
authors.lastname: ElGhazali
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D054340:Receptors, KIR / Q000235:genetics*; D012529:Saudi Arabia
chemical_list: D015235:HLA-B Antigens; C042388:HLA-Bw4 antigen; D054340:Receptors, KIR
keywords: HLA class I ligands; Killer immunoglobulin-like receptor; Saudi population; Type 1 diabetes