title: Genetic Polymorphism of MDM2 SNP309 in Patients with Helicobacter Pylori-Associated Gastritis.
abstract: BACKGROUND
  Helicobacter pylori plays an important role in gastric cancer, which has a relatively low inciduence in Thailand. MDM2 is a major negative regulator of p53, the key tumor suppressor involved in tumorigenesis of the majority of human cancers. Whether its expression might explain the relative lack of gastric cancer in Thailand was assessed here.
  
  
  METHODS
  This single-center study was conducted in the northeast region of Thailand. Gastric mucosa from 100 patients with Helicobacter pylori associated gastritis was analyzed for MDM2 SNP309 using real-time PCR hybridization (light-cycler) probes.
  
  
  RESULTS
  In the total 100 Helicobacter pylori associated gastritis cases the incidence of SNP 309 T/T homozygous was 78 % with SNP309 G/T heterozygous found in 19% and SNP309 G/G homozygous in 3%. The result show SNP 309 T/T and SNP 309 G/T to be rather common in the Thai population.
  
  
  CONCLUSIONS
  Our study indicates that the MDM2 SNP309 G/G homozygous genotype might be a risk factor for gastric cancer in Thailand and the fact that it is infrequent could explain to some extent the low incidence of gastric cancer in the Thai population.
authors.affiliation: Department of Surgery, Suranaree University of Technology, Nakhon Rachasima, Thailand E-mail : taweesak.t@sut.ac.th.
authors.forename: Taweesak
authors.initials: T
authors.lastname: Tongtawee
authors.forename: Chavaboon
authors.initials: C
authors.lastname: Dechsukhum
authors.forename: Wilairat
authors.initials: W
authors.lastname: Leeanansaksiri
authors.forename: Soraya
authors.initials: S
authors.lastname: Kaewpitoon
authors.forename: Natthawut
authors.initials: N
authors.lastname: Kaewpitoon
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Loyd
authors.forename: Likit
authors.initials: L
authors.lastname: Matrakool
authors.forename: Sukij
authors.initials: S
authors.lastname: Panpimanmas
mesh_terms: D044466:Asian People / Q000235:genetics; D004247:DNA / Q000032:analysis*; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry; D005756:Gastritis / Q000150:complications / Q000235:genetics* / Q000382:microbiology; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics; D013785:Thailand
chemical_list: D004247:DNA; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2