title: Roles of lipoprotein receptors in the entry of hepatitis C virus.
abstract: Infection by hepatitis C virus (HCV), a plus-stranded RNA virus that can cause cirrhosis and hepatocellular carcinoma, is one of the major health problems in the world. HCV infection is considered as a multi-step complex process and correlated with abnormal metabolism of lipoprotein. In addition, virus attacks hepatocytes by the initial attaching viral envelop glycoprotein E1/E2 to receptors of lipoproteins on host cells. With the development of HCV model system, mechanisms of HCV cell entry through lipoprotein uptake and its receptor have been extensively studied in detail. Here we summarize recent knowledge about the role of lipoprotein receptors, scavenger receptor class B type I and low-density lipoprotein receptor in the entry of HCV, providing a foundation of novel targeting therapeutic tools against HCV infection.
authors.affiliation: Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Takuo Yoshimoto, Koji Murao, Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Jingya
authors.initials: J
authors.lastname: Lyu
authors.affiliation: Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Takuo Yoshimoto, Koji Murao, Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Imachi
authors.affiliation: Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Takuo Yoshimoto, Koji Murao, Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Kensaku
authors.initials: K
authors.lastname: Fukunaga
authors.affiliation: Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Takuo Yoshimoto, Koji Murao, Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Takuo
authors.initials: T
authors.lastname: Yoshimoto
authors.affiliation: Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Takuo Yoshimoto, Koji Murao, Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Huanxiang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Takuo Yoshimoto, Koji Murao, Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Murao
keywords: CD81; Hepatitis C virus entry; Lipoprotein receptors; Low-density lipoprotein receptor; Scavenger receptor class B type I