title: Genetic background-dependent diversity in renal failure caused by the tensin2 gene deficiency in the mouse.
abstract: Tensin2 (Tns2) is thought to be a component of the cytoskeletal structures linking actin filaments with focal adhesions and is known to play a role as an intracellular signal transduction mediator through integrin in podocytes, although the mechanism by which it functions remains unclear. A Tns2-null mutation (nph) leads to massive albuminuria following podocyte foot process effacement in the ICGN mice, the origin of the mutation, and the DBA/2J (D2) mice, but not in the C57BL/6J (B6) mice or 129(+Ter)/SvJcl (129T) mice. Elucidating the reasons for these differences in diverse genetic backgrounds could help in unraveling Tns2 function in podocytes. We produced congenic mice in which Tns2(nph) was introgressed into a FVB/NJ background (FVB-Tns2(nph)), and evaluated the progression of kidney disease. FVB-Tns2(nph) mice developed albuminuria, renal fibrosis and renal anemia as seen in ICGN mice. The FVB-Tns2(nph) mice demonstrated podocyte foot process alteration under an electron microscope by as early as 4 weeks of age. This revealed that FVB strain is susceptible to Tns2-deficiency.
authors.affiliation: Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University.
authors.forename: Hayato
authors.initials: H
authors.lastname: Sasaki
authors.forename: Kiyoma
authors.initials: K
authors.lastname: Marusugi
authors.forename: Junpei
authors.initials: J
authors.lastname: Kimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kitamura
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nagasaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Torigoe
authors.forename: Takashi
authors.initials: T
authors.lastname: Agui
authors.forename: Nobuya
authors.initials: N
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D051379:Mice; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D051437:Renal Insufficiency / Q000235:genetics*; D000070876:Tensins
chemical_list: D000070876:Tensins; D010749:Phosphoprotein Phosphatases; C511707:Tns2 protein, mouse