title: Estimation of Osteoblastic Functions by Biological Bone Markers.
abstract: The purpose of this study is to identify the lowest value ofNMID osteocalcin and PINP when CTx is below or equal to 0.10 ng/ml at which neither bone formation nor bone resorption occurs. This may be harmful to bone texture. The 223 cases of CTx equal or below 0.100 ng/ml of CTx were enrolled. They consisted of 42 cases or 18.83% of menopausal women, 110 cases or 49.32% ofpost anti-resorptive therapy, 22 cases or 9.8% elderly and 49 cases or 21.97% unknown causes. The results show PINP = 15.88 ng/ml and NMID osteocalcin = 10.81 ng/ml. We used them as a cut value for diagnosis of bone condition. The benefits of this study: helping the physician in the treatment of bone diseases, osteoporosis in cases of over treatment, when the value of CTx is below or above 0.1 ng/ml or 0.01-0.099 ng/ml; when there is no bone resorption and osteoblastic function is poor if the values of NMID osteocalcin or PINP are still equal to 10.81, 15.88 ng/ml at any level of BetacrossLap, respectively.
authors.forename: Narong
authors.initials: N
authors.lastname: Bunyaratavej
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D024042:Collagen Type I / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010006:Osteoblasts / Q000502:physiology*; D015675:Osteocalcin / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011347:Procollagen / Q000097:blood*
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide; D015675:Osteocalcin