title: [Towards a vaccine against HIV: antibodies raised by a gp41 peptide neutralize the virus and inhibit pathogenesis].
abstract: In spite of numerous attempts, only one vaccine candidate showed a potentiality to prevent HIV infection. Such capacity, unfortunately partial, was due to the activity of specific antibodies, indicating the importance of humoral responses. However, the lack of a specific target did not allow to identify an epitope able to stimulate such a response. In addition, in view of a vaccine with preventive and therapeutic activities, it seems of interest to both be able to neutralize the virus and prevent its pathogenesis. We have identified a gp41 peptide inducing antibodies with such dual properties, therefore representing a future vaccine candidate to test functional capacities to fight HIV infection.
authors.forename: Vincent
authors.initials: V
authors.lastname: Vieillard
authors.forename: Patrice
authors.initials: P
authors.lastname: Debré
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D020816:Amino Acid Motifs; D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology*; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002986:Clinical Trials as Topic; D000939:Epitopes / Q000276:immunology; D015483:HIV Antibodies / Q000276:immunology*; D015488:HIV Antigens / Q000276:immunology*; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015700:HIV Envelope Protein gp41 / Q000276:immunology*; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008251:Macaca; D010446:Peptide Fragments / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D057134:Antibodies, Neutralizing; D000939:Epitopes; D015483:HIV Antibodies; D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; D010446:Peptide Fragments; C514793:gp120 protein, Human immunodeficiency virus 1; C514787:gp41 protein, Human immunodeficiency virus 1