title: Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation.
abstract: Endogenous neural stem cells (NSCs) in the adult hippocampus are considered to be bi-potent, as they only produce neurons and astrocytes in vivo. In mouse, we found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue for promoting stem cell plasticity by targeting barriers of latent lineage potential.
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Sun
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Shiori
authors.initials: S
authors.lastname: Ito
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Bonaguidi
authors.affiliation: Pre-doctoral Human Genetics Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Stein-O'Brien
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Nicholas K
authors.initials: NK
authors.lastname: Kawasaki
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Modak
authors.affiliation: Gilbert Family Neurofibromatosis Institute, Center for Cancer and Immunology Research, Children's National Medical Center, Washington, DC, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Guo-li
authors.initials: GL
authors.lastname: Ming
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.|Pre-doctoral Human Genetics Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000235:genetics*; D006624:Hippocampus / Q000166:cytology* / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D025542:Neurofibromin 1 / Q000172:deficiency* / Q000235:genetics*; D009836:Oligodendroglia / Q000378:metabolism
chemical_list: D025542:Neurofibromin 1