title: Genes and environment in neonatal intraventricular hemorrhage.
abstract: Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
authors.affiliation: Department of Pediatrics and Neurology, Yale University School of Medicine, 333 Cedar St, P.O. Box 208064, New Haven, CT 06520-8064. Electronic address: laura.ment@yale.edu.
authors.forename: Laura R
authors.initials: LR
authors.lastname: Ment
authors.affiliation: Department of Women and Child health, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Ulrika
authors.initials: U
authors.lastname: Ådén
authors.affiliation: Department of Pediatrics, University of Miami-Leonard M. Miller School of Medicine, Miami, Florida.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Bauer
authors.affiliation: University of Kentucky, Lexington, KY.
authors.forename: Henrietta S
authors.initials: HS
authors.lastname: Bada
authors.affiliation: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
authors.forename: Waldemar A
authors.initials: WA
authors.lastname: Carlo
authors.affiliation: Department of Pediatrics, University of Arkansas, Little Rock, AR.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Kaiser
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
authors.forename: Aiping
authors.initials: A
authors.lastname: Lin
authors.affiliation: Department of Pediatrics, Duke University, Durham, NC.
authors.forename: Charles Michael
authors.initials: CM
authors.lastname: Cotten
authors.affiliation: Department of Pediatrics, Anatomy and Cell Biology, Biology, Epidemiology, Preventive Medicine, University of Iowa, Iowa City, IA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Murray
authors.affiliation: RTI International, Atlanta, GA.
authors.forename: Grier
authors.initials: G
authors.lastname: Page
authors.affiliation: Department of Pediatrics and Biocenter, University of Oulu and Oulu University Hospital, Oulu, Finland.
authors.forename: Mikko
authors.initials: M
authors.lastname: Hallman
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, CT.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Lifton
authors.affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT.
authors.forename: Heping
authors.initials: H
authors.lastname: Zhang
mesh_terms: D001034:Apgar Score; D002552:Cerebral Ventricles / Q000098:blood supply*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D020300:Intracranial Hemorrhages / Q000209:etiology / Q000235:genetics* / Q000517:prevention & control; D011247:Pregnancy; D012307:Risk Factors; D014481:United States
keywords: GWAS; genes; intraventricular hemorrhage; neonate; preterm