title: [Research Progress on Muscle-derived Stem Cells Capable of Hematopoiesis].
abstract: Muscle-derived stem cells (MDSC) are defined as myogenic stem cells endowed with their ability to self-renew and differentiate into multiple cell types of their derivative tissue, and are proved to be over 10 times more efficient in hematopoiesis than hematopoietic stem cells (HSC). Although the mechanism which MDSC differentiate into blood cells is still unclear, MDSC were considered to replace HSC to treat the patients suffering from bone marrow diseases such as aplastic anemia and tumor. MDSC are different from HSC in a variety aspects like biological characteristics, protein expression and cell proliferation. On the other hand, MDSC contain multiple distinct stem cell populations. Among these, there is only a small part with the ability to repopulate hematopoietic cells, and it is still uncertain whether their origin is same as HSC. This review summarizes the difference between MDSC and HSC, the ability of MDSC to repopulate hematopoietic cells, and the prospect of MDSCs' transplantation.
authors.affiliation: Department of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Chen
authors.affiliation: Department of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Wang
authors.affiliation: College of Tradional Chinese Medicine Integrated with Western Medicine, Tianjin Uneversity of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: College of Tradional Chinese Medicine Integrated with Western Medicine, Tianjin Uneversity of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Gao
authors.affiliation: College of Tradional Chinese Medicine Integrated with Western Medicine, Tianjin Uneversity of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Wang
authors.affiliation: College of Tradional Chinese Medicine Integrated with Western Medicine, Tianjin Uneversity of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Shu-Wu
authors.initials: SW
authors.lastname: Zhao
authors.affiliation: College of Tradional Chinese Medicine Integrated with Western Medicine, Tianjin Uneversity of Traditional Chinese Medicine, Tianjin 300193, China. E-mail: wangtao6112@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Nursing, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. E-mail: douhaoying11@126.com.
authors.forename: Hao-Ying
authors.initials: HY
authors.lastname: Dou
mesh_terms: D000741:Anemia, Aplastic; D002454:Cell Differentiation; D049109:Cell Proliferation; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D018482:Muscle, Skeletal / Q000166:cytology*