title: [Unrelated Donor Peripheral Blood Stem Cell Transplantation Combined with Umbilical Cord Mesenchymal Stem Cells in Patients with Hematologic Malignancies].
abstract: OBJECTIVE
  To explore the safety and efficiency of unrelated donor peripheral blood stem cells (URD-PBSC) transplantation combined with umbilical cord mesenchymal stem cells (UC-MSC).
  
  
  METHODS
  The clinical data of 49 patients received unrelated donor peripheral blood stem cells transplantation (URD-PBSCT) for treating hematologic malignancies were retrospectively evaluated, including 12 ANLL, 17 ALL, 18 CML and 2 MDS. Out of them, 22 patients received the URD-PBSCT combined with UC-MSC and 27 patients received only URD-PBSCT. The average number of infusing UC-MSC was 1.0 × 10⁶/kg in the UC-MSC+URD-PBSCT group.
  
  
  RESULTS
  As compared with URD-PBSCT group, in UC-MSC+URD-PBSCT group the median recovery time of neutrophilc granulocytes was shorter (12 d vs 15 d) (P = 0.041), the incidence and severity of chronic graft versus host disease (cGVHD) were lower (20.0% vs 51.9%) (P = 0.026) (5.0% vs 33.3%) (P = 0.040), the incidence of CMV infection after transplantation was higher (81.8% vs 51.9%) (P = 0.028). In addition to these, the differences were not statistically significant in term of implantation level, PLT reconstitution, aGVHD, lung infection, hemorrhagic cystitis, 1-year relapse and survival between the 2 groups (P > 0.05).
  
  
  CONCLUSIONS
  The transplantation of URD-PBSC combined with UC-MSC is effective and safe. The speed of neutrophils reconstitution is faster. The incidence and severity of cGVHD are lower, but the attention should be paid to prevent the CMV infection.
authors.affiliation: Department of Clinical Medicine, Dalian Medical University, Dalian 116044, Liaoning Province, China.
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Zhang
authors.affiliation: Department of Clinical Medicine, Dalian Medical University, Dalian 116044, Liaoning Province, China. E-mail: duanlianning@hotmail.com.
authors.forename: Lian-Ning
authors.initials: LN
authors.lastname: Duan
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Yan
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Zhi-Dong
authors.initials: ZD
authors.lastname: Wang
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zheng
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Xue
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Hematology, General Hospital of Chinese Air Force, Beijing 100142, China.
authors.forename: Heng-Xiang
authors.initials: HX
authors.lastname: Wang
mesh_terms: D003586:Cytomegalovirus Infections; D006086:Graft vs Host Disease; D019337:Hematologic Neoplasms / Q000628:therapy*; D006801:Humans; D015994:Incidence; D045164:Mesenchymal Stem Cell Transplantation; D009364:Neoplasm Recurrence, Local; D036102:Peripheral Blood Stem Cell Transplantation; D012189:Retrospective Studies; D014470:Umbilical Cord / Q000166:cytology; D061349:Unrelated Donors