title: Acute loss of vision after an intravitreal injection ocriplasmin: a functional evolutionary study for 1-year follow-up.
abstract: BACKGROUND
  Ocriplasmin is a human plasmin fragment indicated for vitreomacular traction treatment. With its increasing use, several reported cases have suggested possible toxicity to the retina.
  
  
  METHODS
  We describe a case of a 55-year-old woman with symptomatic vitreomacular traction and a macular hole in the right eye who showed an acute decrease in visual acuity after an intravitreal ocriplasmin injection. Spectral-domain optical coherence tomography showed an alteration in the ellipsoid layer. Significant retinal vessel constriction was observed by angiography. The visual acuity improved to 20/100, and the electroretinogram progressively improved after the 1-year follow-up and following pars plana vitrectomy.
  
  
  CONCLUSIONS
  A decrease in visual acuity and an enlargement of the macular hole were observed while studying this patient. This study shows the recovery of adverse effects caused by intravitreal injection of ocriplasmin for 1-year follow-up.
authors.affiliation: Instituto Oftalmológico Gómez-Ulla, Calle Maruxa Mallo 3, 15706, Santiago de Compostela, Spain. franciscogomez-ulla@institutogomez-ulla.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Gómez-Ulla
authors.affiliation: Expert Retina Training Program, Hospital Provincial de Conxo, Santiago de Compostela, Spain. verman017@hotmail.com.
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Bande
authors.affiliation: Instituto Oftalmológico Gómez-Ulla, Calle Maruxa Mallo 3, 15706, Santiago de Compostela, Spain. maxiabraldes@gmail.com.
authors.forename: Maximino
authors.initials: M
authors.lastname: Abraldes
mesh_terms: D000208:Acute Disease; D001766:Blindness / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D004596:Electroretinography; D005128:Eye Diseases / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005341:Fibrinolysin / Q000009:adverse effects*; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D058449:Intravitreal Injections; D008875:Middle Aged; D010446:Peptide Fragments / Q000009:adverse effects*; D012167:Retinal Perforations / Q000188:drug therapy / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000187:drug effects*; D014822:Vitreous Body / Q000187:drug effects / Q000503:physiopathology
chemical_list: D005343:Fibrinolytic Agents; D010446:Peptide Fragments; C054561:microplasmin; D005341:Fibrinolysin
keywords: Electroretinogram; Ocriplasmin; Vitreomacular traction