title: Reduction in semen quality after mixed exposure to bisphenol A and isobutylparaben in utero and during lactation periods.
abstract: This study was performed to determine the effect of low-level exposure to a mixture of bisphenol A (BPA) and isobutylparaben (IBP) on male reproduction. Corn oil, BPA (0.05 mg/kg/day), IBP (2.5 mg/kg/day), and a BPA/IBP mixture (BPA 0.05 mg/kg/day and IBP 2.5 mg/kg/day) were administered once daily by oral gavage to female rats for 5 weeks from gestation day 6 to lactation day 21. Male pups were killed at postnatal day 70 and examined for developmental characteristics, body weight, testis and epididymis weight, steroid hormones, epididymal sperm count and motility, and histological changes in testis and epididymis. The BPA/IBP mixture produced a significant downregulation of epididymal sperm count and motility. BPA or IBP alone also reduced epididymal sperm count and motility compared to control. These results indicate that exposure to low-level BPA/IBP mixture, which showed no notable physiological response in early life stages, can decrease semen quality in adulthood.
authors.affiliation: Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Korea Institute for Integrative Medicine, Catholic Kwandong University International St. Mary's Hospital, Incheon, Korea.
authors.forename: Yun-Jung
authors.initials: YJ
authors.lastname: Yang
authors.affiliation: Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Korea hyp026@cau.ac.kr.
authors.forename: Yeon-Pyo
authors.initials: YP
authors.lastname: Hong
authors.affiliation: Department of Pediatrics, College of Medicine, Chung-Ang University, Seoul, Korea.
authors.forename: Soo Ahn
authors.initials: SA
authors.lastname: Chae
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D004357:Drug Synergism; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D004822:Epididymis / Q000187:drug effects / Q000473:pathology; D005260:Female; D042341:Gonadal Hormones / Q000097:blood; D007774:Lactation / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010226:Parabens / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D010636:Phenols / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000473:pathology; D017207:Rats, Sprague-Dawley; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000473:pathology; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D042341:Gonadal Hormones; D010226:Parabens; D010636:Phenols; C471067:isobutylparaben; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; early life stage; isobutylparaben; low dose; mixture; sperm toxicity