title: Proactive Semantic Interference is Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders: A Preliminary Study.
abstract: OBJECTIVE
  To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders.
  
  
  METHODS
  27 participants (11 cognitively normal [CN] with subjective memory complaints, 8 CN without memory complaints, and 8 with mild cognitive impairment [MCI]) underwent complete neurological and neuropsychological evaluations. Participants also received the Semantic Interference Test (SIT) and AV-45 amyloid PET imaging.
  
  
  RESULTS
  High levels of association were present between total amyloid load, regional amyloid levels, and the PSI measure (in the entire sample and a subsample excluding MCI subjects). RSI and other memory measures showed much weaker associations or no associations with total and regional amyloid load. No associations between amyloid levels and non-memory performance were observed.
  
  
  CONCLUSIONS
  In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center on Aging, Miami, FL; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL. Electronic address: DLoewenstein@med.miami.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Loewenstein
authors.affiliation: Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Greig
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center on Aging, Miami, FL.
authors.forename: Rosie
authors.initials: R
authors.lastname: Curiel
authors.affiliation: Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL.
authors.forename: Rosemarie
authors.initials: R
authors.lastname: Rodriguez
authors.affiliation: Department of Neurology, University of Florida, Gainesville, FL.
authors.forename: Meredith
authors.initials: M
authors.lastname: Wicklund
authors.affiliation: Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL.
authors.forename: Warren W
authors.initials: WW
authors.lastname: Barker
authors.affiliation: Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Hidalgo
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center on Aging, Miami, FL.
authors.forename: Marian
authors.initials: M
authors.lastname: Rosado
authors.affiliation: Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL; Department of Neurology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Duara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D015577:Geriatric Assessment / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D012111:Residence Characteristics; D012660:Semantics
chemical_list: D000682:Amyloid
keywords: Amyloid; MCI; proactive interference; semantic interference