title: Calciphylaxis: a case series and the role of radiology in diagnosis.
abstract: BACKGROUND
  Calciphylaxis is a syndrome of vascular calcification most commonly affecting patients with end-stage renal disease (ESRD) on hemodialysis. Because of its high mortality rate, early diagnosis and treatment are necessary. Although diagnosis is usually based on skin biopsy, histopathology is often nonspecific. As the role of imaging in calciphylaxis has not been studied extensively, we examined the utility of radiology in the diagnosis of this disease.
  
  
  METHODS
  A thorough review of electronic medical records for 2005-2013 at Loyola University Medical Center yielded 10 patients with biopsy-proven calciphylaxis. Using the radiological picture archiving and communication system (PACS), all imaging studies of the affected body part obtained within 6 months of diagnosis were analyzed and tabulated.
  
  
  RESULTS
  All 10 patients had undergone imaging (computed tomography, ultrasound, plain radiography, and/or mammography) of the affected anatomy prior to diagnosis by skin biopsy. Nine of these patients were noted to have moderate-to-severe soft tissue vascular calcification in the area of skin biopsy.
  
  
  CONCLUSIONS
  This case series supports the suggestion that findings of superficial vascular calcifications on imaging studies are sensitive for the diagnosis of calciphylaxis. Used in conjunction with histopathological, clinical, and laboratory data, radiology can serve an important role in the diagnosis of calciphylaxis.
authors.affiliation: Division of Dermatology, The Ohio State Wexner Medical Center, Columbus, OH, USA.
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Bonchak
authors.affiliation: Division of Dermatology, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Park
authors.affiliation: Department of Radiology, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: Talentshia
authors.initials: T
authors.lastname: Vethanayagamony
authors.affiliation: Department of Radiology, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: M Mukarram
authors.initials: MM
authors.lastname: Sheikh
authors.affiliation: Division of Dermatology, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: Laura S
authors.initials: LS
authors.lastname: Winterfield
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001808:Blood Vessels / Q000000981:diagnostic imaging*; D002115:Calciphylaxis / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008327:Mammography; D008875:Middle Aged; D011859:Radiography; D012867:Skin / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D018615:Ultrasonography, Doppler, Color