title: The Role of Pyruvate Kinase M2 in Cancer Metabolism.
abstract: The M2 isoform of pyruvate kinase is expressed preferentially in cancer cells over other pyruvate kinase isoforms. PKM2 is unique in its ability to be regulated allosterically by nutrients and growth signaling pathways, allowing cells to adapt their metabolic program to match physiological needs in different environments. Here, we discuss the role of pyruvate kinase M2 in glioma and in cancer metabolism.
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.|Harvard-MIT Health Sciences and Technology Division, Harvard Medical School, Boston, MA.
authors.forename: Vivian M
authors.identifier: http://orcid.org/0000-0002-9118-6204
authors.initials: VM
authors.lastname: Liu
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.|Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Vander Heiden
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D011770:Pyruvate Kinase / Q000378:metabolism*
chemical_list: D011770:Pyruvate Kinase
keywords: cancer metabolism; glycolysis; pyruvate kinase M2