title: Impacts on the third line of defense specialized against microbial infection as a result of exposure to gamma-radiation.
abstract: To understand the toxicity and the potential role of gamma-radiation (GR) as a therapeutic tool, the effects of different GR doses on haematological and dimensional properties of rats' blood were investigated in vivo. 60 healthy male Wistar-Kyoto rats were used in this study, and were randomly divided into 5 groups, 4 GR rat groups (1st group was radiated with 5 R, 2nd group 25 Gy; 3rd group with 50 Gy, 4th group with 100 Gy and 5th group was the control). Different haematological and dimensional parameters were measured using the standard haematological technique for complete blood count (CBC). A significant decrease in white blood cells (WBCs) count and lymphocytes (LYM) was observed compared with the control. While a significant increase in monocytes (MON), neutrophils (NEU), basophils (BAS), and eosinophils (EOS) were observed. A non-significant decrease in platelets (PLTs) count was observed with GR compared with the control.
authors.affiliation: Biomedical Physics Specialty, Physics and Astronomy Dept., Science College, King Saud University, KSA.
authors.forename: Mohamed Anwar Kassem
authors.initials: MA
authors.lastname: Abd El-Halim
authors.affiliation: Microbiology specialty, Microbiology Br., Biology Dept., Science College, Taif University, KSA.
authors.forename: Sherifa Mostafa
authors.initials: SM
authors.lastname: Mohamed Sabra
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000532:radiotherapy*; D001772:Blood Cell Count; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects; D006098:Granulocytes / Q000528:radiation effects; D007958:Leukocyte Count; D007962:Leukocytes / Q000528:radiation effects; D008297:Male; D010976:Platelet Count; D051381:Rats; D011921:Rats, Inbred WKY