title: Impaired systemic vascular endothelial function in patients with non-arteritic anterior ischaemic optic neuropathy.
abstract: OBJECTIVE
  The purpose of this study was to evaluate systemic endothelial function in elderly hypertension patients with non-arteritic anterior ischaemic optic neuropathy (NAION) by using a noninvasive physiological method: endothelium-dependent, flow-mediated vasodilation (FMD).
  
  
  METHODS
  Forty-two systemic hypertension patients with NAION (NAION group), 64 age- and sex-matched patients with systemic hypertension and no other ocular disease (hypertension group), and 100 age- and sex-matched healthy volunteers (normal group) were enrolled. FMD was evaluated using a high-resolution ultrasonography. Traditional cardiovascular risk factors and vascular parameters were measured.
  
  
  RESULTS
  Systolic blood pressure and diastolic blood pressure were significantly higher in patients with NAION compared with the control groups (p < 0.001). The FMD decreased significantly in the NAION group (6.02 ± 1.87 %) compared to in the hypertension group (7.86 ± 2.94 %, p < 0.001) and the normal group (8.99 ± 2.44 %, p < 0.001). By multivariable logistic regression analysis, FMD was significantly associated with NAION (OR, 1.79; 95%CI, 1.67-2.01).
  
  
  CONCLUSIONS
  NAION may be associated with systemic vascular endothelial dysfunction. FMD might be useful in the treatment monitoring of NAION.
authors.affiliation: Department of Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, 510080.
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Yao
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, #58 Zhongshan Second Road, Guangzhou, Guangdong, China, 510080.
authors.forename: Pengxia
authors.initials: P
authors.lastname: Wan
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, #58 Zhongshan Second Road, Guangzhou, Guangdong, China, 510080.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, #58 Zhongshan Second Road, Guangzhou, Guangdong, China, 510080.
authors.forename: Ruiduan
authors.initials: R
authors.lastname: Liao
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Sun Yat-sen University, #58 Zhongshan Second Road, Guangzhou, Guangdong, China, 510080. dctzwh@139.com.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Zhu
mesh_terms: D001167:Arteritis / Q000503:physiopathology; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012307:Risk Factors; D018608:Ultrasonography, Doppler; D014664:Vasodilation / Q000502:physiology
keywords: Doppler sonography; Endothelial function; Nitric oxide; Non-arteritic anterior ischaemic optic neuropathy; Vasodilation