title: Oral Contraceptives Use and Liver Cancer Risk: A Dose-Response Meta-Analysis of Observational Studies.
abstract: Studies about the association between oral contraceptives use and liver cancer risk have generated controversial results. Therefore, a meta-analysis of cohort and case-control studies was performed to quantitatively summarize the existing evidence.Eligible studies were identified by a computer search of PubMed and Embase databases and handed-search of reference lists, without any limitations. Study-specific risk estimates (RRs) with 95% confidence intervals (CIs) were combined with random-effects model.A total of 17 articles were included in this meta-analysis. Overall, there was no statistically significant association between oral contraceptives use and liver cancer risk (RR: 1.23, 95% CI: 0.93-1.63). In a dose-analysis of meta-analysis, a linear relationship between oral contraceptives use and liver cancer risk (P for linearity = 0.391) was found, although this correlation was not statistically significant.Oral contraceptives use was not positively associated with the risk of liver cancer.
authors.affiliation: From the Department of Hepatopancreatobiliary Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
authors.forename: Ning
authors.initials: N
authors.lastname: An
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced*; D064887:Observational Studies as Topic
chemical_list: D003278:Contraceptives, Oral, Hormonal