title: VITAMIN D DEFICIENCY DOES NOT AFFECT THE LIKELIHOOD OF PRESURGICAL LOCALIZATION IN ASYMPTOMATIC PRIMARY HYPERPARATHYROIDISM.
abstract: OBJECTIVE
  Vitamin D deficiency (VDD) was previously associated with larger adenoma size in primary hyperparathyroidism (PHPT), but this topic was not addressed in patients with the mild/asymptomatic form of the disease (aPHPT).
  
  
  METHODS
  We retrospectively retrieved from our series of patients affected by PHPT, 96 consecutive subjects with aPHPT in whom 25-hydroxyvitamin D (25OHD) levels had been assayed and compared those results with localizing imaging studies.
  
  
  RESULTS
  Twenty-five of 96 patients had VDD (25OHD <20 ng/mL), but positive ultrasound and scintigraphic studies were not different between patients with and without VDD (52.3% versus 55.7% and 42.9% versus 52.4%, respectively). Upon logistic regression analysis, after adjusting for different variables, including the presence of goiter, VDD was not an independent predictor of localization by imaging studies.
  
  
  CONCLUSIONS
  VDD does not affect the likelihood of positive pre-operative imaging in aPHPT and the consequent surgical decisions.
authors.forename: Francesco
authors.initials: F
authors.lastname: Tassone
authors.forename: Elena
authors.initials: E
authors.lastname: Castellano
authors.forename: Laura
authors.initials: L
authors.lastname: Gianotti
authors.forename: Franco
authors.initials: F
authors.lastname: Acchiardi
authors.forename: Ignazio
authors.initials: I
authors.lastname: Emmolo
authors.forename: Roberto
authors.initials: R
authors.lastname: Attanasio
authors.forename: Giorgio
authors.initials: G
authors.lastname: Borretta
mesh_terms: D000236:Adenoma / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D000368:Aged; D058070:Asymptomatic Diseases; D002112:Calcifediol / Q000097:blood; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D057234:Preoperative Period; D012189:Retrospective Studies; D017256:Technetium Tc 99m Sestamibi; D014463:Ultrasonography; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D017256:Technetium Tc 99m Sestamibi; C104450:25-hydroxyvitamin D; D002112:Calcifediol