title: Cortical Structural Connectivity Alterations in Primary Insomnia: Insights from MRI-Based Morphometric Correlation Analysis.
abstract: The etiology and maintenance of insomnia are proposed to be associated with increased cognitive and physiological arousal caused by acute stressors and associated cognitive rumination. A core feature of such hyperarousal theory of insomnia involves increased sensory processing that interferes with the onset and maintenance of sleep. In this work, we collected structural magnetic resonance imaging data from 35 patients with primary insomnia and 35 normal sleepers and applied structural covariance analysis to investigate whether insomnia is associated with disruptions in structural brain networks centered at the sensory regions (primary visual, primary auditory, and olfactory cortex). As expected, insomnia patients showed increased structural covariance in cortical thickness between sensory and motor regions. We also observed trends of increased covariance between sensory regions and the default-mode network, and the salience network regions, and trends of decreased covariance between sensory regions and the frontoparietal working memory network regions, in insomnia patients. The observed changes in structural covariance tended to correlated with poor sleep quality. Our findings support previous functional neuroimaging studies and provide novel insights into variations in brain network configuration that may be involved in the pathophysiology of insomnia.
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan 450003, China.
authors.forename: Enfeng
authors.initials: E
authors.lastname: Wang
authors.affiliation: Department of Radiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan 450003, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4 ; Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada H4H 1R3.
authors.forename: Sherif
authors.initials: S
authors.lastname: Karama
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4.
authors.forename: Budhachandra
authors.initials: B
authors.lastname: Khundrakpam
authors.affiliation: Department of Neurology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan 450003, China.
authors.forename: Hongju
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan 450003, China.
authors.forename: Min
authors.initials: M
authors.lastname: Guan
authors.affiliation: Department of Radiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan 450003, China.
authors.forename: Meiyun
authors.initials: M
authors.lastname: Wang
authors.affiliation: MRI Division, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
authors.forename: Jingliang
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Radiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan 450003, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Shi
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4.
authors.forename: Alan C
authors.initials: AC
authors.lastname: Evans
authors.affiliation: Department of Radiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan 450003, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology*; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology*; D055815:Young Adult