title: Autologous platelet concentrate in surgery for macular detachment associated with congenital optic disc pit.
abstract: OBJECTIVE
  To evaluate the anatomical and functional results obtained with pars plana vitrectomy (PPV) plus autologous platelet concentrate (APC) as a treatment for macular detachment associated with optic disc pit (ODP).
  
  
  METHODS
  We performed a prospective interventional study of 19 eyes of 19 consecutive patients with posterior macular detachment due to ODP. All patients underwent PPV, posterior hyaloid peeling, fluid-air exchange, injection of 0.05 mL of APC over the ODP and 15% perfluoropropane (C3F8) endotamponade. Postoperative measures included face-up positioning for 2 hours and then avoidance of the face-up position during the ensuing 10 days. All patients underwent complete ophthalmologic examination and optical coherence tomography preoperatively at 1 month, 3 months, 6 months, 9 months, and 12 months postoperatively and then annually. Outcome measures were best corrected visual acuity (BCVA) by logMAR, improvement of quality of vision, macular attachment, and resolution of intraretinal schisis-like separation.
  
  
  RESULTS
  Preoperatively, the median BCVA was 0.70 (range: 0.30-1.70) and all patients showed improved visual acuity after surgery; BCVA was 0.22 (range: 0.07-0.52) at 12 months follow-up. All patients showed complete reabsorption of intraretinal fluid (median time: 3.5 months [range: 2-8 months]) and macular attachment at the end of follow-up (median: 60 months [range: 12-144 months]), with stable or improved visual acuity. No reoperations were needed and no major adverse events were recorded.
  
  
  CONCLUSIONS
  For macular detachment associated with ODP, the combination of PPV, posterior hyaloid peeling, APC, and C3F8 tamponade is a highly effective alternative technique with stable anatomical and functional results.
authors.affiliation: Vitreoretinal Surgery Department at Centro de Oftalmología Barraquer, Barcelona, Spain ; Universitat autónoma de Barcelona, Barcelona, Spain.
authors.forename: Jeroni
authors.initials: J
authors.lastname: Nadal
authors.affiliation: Vissum Madrid, Madrid, Spain.
authors.forename: Marta S
authors.initials: MS
authors.lastname: Figueroa
authors.affiliation: Universitat autónoma de Barcelona, Barcelona, Spain ; Instituto Barraquer, Barcelona, Spain.
authors.forename: Elisa
authors.initials: E
authors.lastname: Carreras
authors.affiliation: Universitat autónoma de Barcelona, Barcelona, Spain ; Instituto Barraquer, Barcelona, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Pujol
authors.affiliation: Universitat autónoma de Barcelona, Barcelona, Spain ; Instituto Barraquer, Barcelona, Spain ; Glaucoma Department at Centro de Oftalmología Barraquer, Barcelona, Spain.
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Canut
authors.affiliation: Universitat autónoma de Barcelona, Barcelona, Spain ; Cornea and Cataract Surgery Department at Centro de Oftalmología Barraquer, Barcelona, Spain.
authors.forename: Rafael Ignacio
authors.initials: RI
authors.lastname: Barraquer
keywords: autologous platelet concentrate; macular detachment; maculopathy; optic disc pit; pars plana vitrectomy; retinoschisis