title: Asymmetric Aldol-Tishchenko Reaction of Sulfinimines.
abstract: Methods for the preparation of 1,3-amino alcohols and their derivatives containing two stereogenic centers usually involve a two-step installation of the chiral centers. An aldol-Tishchenko reaction of chiral sulfinimines which involves the first reported reduction of a C═N in this type of reaction is described. Two and even three chiral centers can be installed in one synthetic step, affording anti-1,3-amino alcohols in good diastereo- and enantioselectivity.
authors.affiliation: Analytical and Biological Chemistry Research Facility and Department of Chemistry, University College Cork , Cork 021, Ireland.
authors.forename: Vera M
authors.initials: VM
authors.lastname: Foley
authors.affiliation: Analytical and Biological Chemistry Research Facility and Department of Chemistry, University College Cork , Cork 021, Ireland.
authors.forename: Christina M
authors.initials: CM
authors.lastname: McSweeney
authors.affiliation: Analytical and Biological Chemistry Research Facility and Department of Chemistry, University College Cork , Cork 021, Ireland.
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Eccles
authors.affiliation: Analytical and Biological Chemistry Research Facility and Department of Chemistry, University College Cork , Cork 021, Ireland.
authors.forename: Simon E
authors.initials: SE
authors.lastname: Lawrence
authors.affiliation: Analytical and Biological Chemistry Research Facility and Department of Chemistry, University College Cork , Cork 021, Ireland.
authors.forename: Gerard P
authors.initials: GP
authors.lastname: McGlacken