title: Suprasellar Primitive Neuroectodermal Tumor in an Adult.
abstract: Primitive neuroectodermal tumors (PNET) of the central nervous system (CNS) are a heterogeneous group of embryonal malignancies that are composed of undifferentiated or poorly differentiated neuroepithelial cells. Supratentorial PNET is the second most common CNS embryonal malignancy in children, but it is rare in adults. We report the case of a 31-year-old woman with bilateral vision loss and a bitemporal hemianopia. Neuroimaging revealed a suprasellar mass, and pathology was consistent with PNET. After surgical debulking of the tumor followed by radiation therapy and chemotherapy, the patient had significant visual recovery and remained stable over 14 months of follow-up.
authors.affiliation: Department of Ophthalmology (AEBP), Centro Médico Zambrano Hellion-Tec Salud, Monterrey, Mexico; Department of Ophthalmology (KK, AGL), Baylor College of Medicine, Houston, Texas; Department of Ophthalmology, Houston Methodist Hospital, Houston, Texas; Department of Pathology and Genomic Medicine (MLM, AGL), Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology (AGL), Neurology, and Neurosurgery, Weill Cornell Medical College, Houston, Texas; Department of Ophthalmology (AGL), UTMB Galveston, Texas; The UT M.D. Anderson Cancer Center (AGL), Houston, Texas; and The University of Iowa Hospitals and Clinics (AGL), Iowa City, Iowa.
authors.forename: Angelina
authors.initials: A
authors.lastname: Espino Barros Palau
authors.forename: Khurrum
authors.initials: K
authors.lastname: Khan
authors.forename: Michael L
authors.initials: ML
authors.lastname: Morgan
authors.forename: Suzanne Z
authors.initials: SZ
authors.lastname: Powell
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Lee
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018242:Neuroectodermal Tumors, Primitive / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D019635:Neurosurgical Procedures / Q000379:methods; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D014792:Visual Acuity