title: Assessing protein-protein interactions based on the semantic similarity of interacting proteins.
abstract: The Gene Ontology (GO) has been used in estimating the semantic similarity of proteins since it has the largest and reliable vocabulary of gene products and characteristics. We developed a new method which can assess Protein-Protein Interactions (PPI) using the branching factor and information content of the common ancestor of interacting proteins in the GO hierarchy. We performed a comparative evaluation of the measure with other GO-based similarity measures and evaluation results showed that our method outperformed others in most GO domains.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Cui
authors.forename: Byungmin
authors.initials: B
authors.lastname: Kim
authors.forename: Saud
authors.initials: S
authors.lastname: Alguwaizani
authors.forename: Kyungsook
authors.initials: K
authors.lastname: Han
mesh_terms: D063990:Gene Ontology; D006801:Humans; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D011506:Proteins