title: Comparative toxicity and mutagenicity of soy-biodiesel and petroleum-diesel emissions: overview of studies from the U.S. EPA, Research Triangle Park, NC.
abstract: Biodiesel use as a fuel is increasing globally as an alternate to petroleum sources. To comprehensively assess the effects of the use of biodiesel as an energy source, end stage uses of biodiesel such as the effects of inhalation of combusted products on human health must be incorporated. To date, few reports concerning the toxicological effects of the emissions of combusted biodiesel or blends of biodiesel on surrogates of health effects have been published. The relative toxicity of the combusted biodiesel emissions compared to petroleum diesel emissions with short term exposures is also not well known. To address the paucity of findings on the toxicity of combusted biodiesel emissions, studies were undertaken at the U.S. Environmental Protection Agency laboratories in Research Triangle Park, North Carolina. The studies used a variety of approaches with nonhuman animal models to examine biological responses of the lung and cardiovascular systems induced by acute and repeated exposures to pure biodiesel and biodiesel blended with petroleum diesel. Effects of the emissions on induction of mutations in bacterial test strains and mammalian DNA adducts were also characterized and normalized to engine work load. The emissions were characterized as to the physicochemical composition in order to determine the magnitude of the differences among the emissions utilized in the studies. This article summarizes the major finding of these studies which are contained within this special issue of Inhalation Toxicology. The findings provided in these articles provide information about the toxicity of biodiesel emissions relative to petroleum diesel emissions and which can be utilized in a life cycle analyses of the effects of increased biodiesel usage.
authors.affiliation: a National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency , Research Triangle Park , NC , USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Madden
mesh_terms: D000818:Animals; D056804:Biofuels / Q000633:toxicity*; D006801:Humans; D009153:Mutagens / Q000633:toxicity*; D009657:North Carolina; D010578:Petroleum / Q000633:toxicity*; D013025:Glycine max / Q000633:toxicity*; D014481:United States; D014484:United States Environmental Protection Agency / Q000592:standards*; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D056804:Biofuels; D009153:Mutagens; D010578:Petroleum; D001335:Vehicle Emissions
keywords: asthma; cardiovascular; diesel; inhalation; lung; mutagenicity; soy biodiesel; toxicity