title: Association between Dietary Vitamin A Intake and the Risk of Glioma: Evidence from a Meta-analysis.
abstract: The results from epidemiological studies between dietary vitamin A intake and glioma risk is not consistent. Thus, a meta-analysis was conducted to confirm the exact relationship between them. PubMed and Web of Knowledge were used to search the relevant articles up to May 2015. Pooled relative risk (RR) with 95% confidence interval (CI)was calculated using random-effect model. Egger's test was used to assess the small-study effect. At the end, seven articles with eight case-control studies involving 1841 glioma cases and 4123 participants were included. Our study indicated that highest category of dietary vitamin A intake was significantly associated with reduced risk of glioma (RR = 0.80, 95% CI = 0.62-0.98, p = 0.014, I² = 54.9%). Egger's test did not find any publication bias. In conclusion, our study indicated that higher category of dietary vitamin A intake could reduce the glioma risk. However, we could not do a dose-response analysis for vitamin A intake with glioma risk due to the limited data in each reported individual article. Due to this limitation, further studies with detailed dose, cases and person-years for each category is wanted to assess this dose-response association.
authors.affiliation: Department of Internal Neurology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. wenlv123@yeah.net.
authors.forename: Wen
authors.initials: W
authors.lastname: Lv
authors.affiliation: Department of Medical Oncology, Hangzhou Binjiang Hospital, Hangzhou 310052, China. xianzhong123@yeah.net.
authors.forename: Xian
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. lingminxu123@yeah.net.
authors.forename: Lingmin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. weidonghan888@yeah.net.
authors.forename: Weidong
authors.initials: W
authors.lastname: Han
mesh_terms: D004032:Diet; D005260:Female; D005910:Glioma / Q000517:prevention & control*; D006801:Humans; D008297:Male; D014801:Vitamin A / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D014815:Vitamins; D014801:Vitamin A
keywords: glioma; meta-analysis; vitamin A