title: A review of potential pharmacogenetic effects on catecholamine responses.
abstract: Considerably, variability in the clinical response to inotropic agents is observed and could be explained partially by the genetic variants, such as single-nucleotide polymorphism (SNP) in genes encoding for enzymes implicated in catecholamines synthesis, metabolism, storage and release or in the signaling pathway. This review highlights the potential effect of pharmacogenetics studies in hemodynamic response and identified 11 SNPs that could be relevant to explain the high variability drug response for a same dose. Cardiovascular instability, such as hypotension, is one of the premature birth complications. The pharmacogenetics studies evaluating these SNP may be useful to better understand the clinical outcome, particularly in this population.
authors.affiliation: a Université Paris Descartes, INSERM U1129 , Paris , France .
authors.forename: Marwa
authors.initials: M
authors.lastname: Ounissi
authors.affiliation: a Université Paris Descartes, INSERM U1129 , Paris , France .
authors.forename: Aida
authors.initials: A
authors.lastname: Benkirane
authors.affiliation: b Department of Pediatrics and Child Health , University College and Irish Centre for Fetal and Neonatal Translational Research (INFANT) , Cork , Ireland .
authors.forename: Eugene
authors.initials: E
authors.lastname: Dempsey
authors.affiliation: a Université Paris Descartes, INSERM U1129 , Paris , France .
authors.forename: Ricardo
authors.initials: R
authors.lastname: Soares
authors.affiliation: a Université Paris Descartes, INSERM U1129 , Paris , France .|c Service De Pharmacologie, Hôpital Européen Georges Pompidou , Paris , France .
authors.forename: Vincent
authors.initials: V
authors.lastname: Jullien
authors.affiliation: a Université Paris Descartes, INSERM U1129 , Paris , France .
authors.forename: Gérard
authors.initials: G
authors.lastname: Pons
authors.affiliation: d Institut Necker Enfants-Malades (INEM), INSERM U1151 , Paris , France , and.|e Laboratoire D'immunologie Biologique , Hôpital Universitaire Necker-Enfants Malades , AP-HP Paris , France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Chhun
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics; D002395:Catecholamines / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007022:Hypotension / Q000151:congenital / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011941:Receptors, Adrenergic / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D002395:Catecholamines; D011941:Receptors, Adrenergic
keywords: Hypotension; drug metabolism; pharmacogenetics; premature neonates; single-nucleotide polymorphism