title: Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature.
abstract: Hyperammonemia is an uncommon side effect of topiramate (TPM) that has only been reported when it is used as an adjunct to valproate. We report a patient with mental retardation who developed reversible encephalopathy from TPM. Ammonia level was monitored during the course of TPM treatment. This patient had recurring, reversible elevations in serum ammonia levels that coincided with the administration of TPM. To our knowledge, symptomatic hyperammonemia has not been reported to occur with TPM monotherapy.
authors.affiliation: Texas Tech University Health Sciences Center, Department of Neurology, 3601 4th Street, STOP 8321, Lubbock 79430-8321, TX, USA.
authors.forename: Sahawat
authors.initials: S
authors.lastname: Tantikittichaikul
authors.affiliation: Texas Tech University Health Sciences Center, School of Medicine, 3601 4th Street, Lubbock 79430, TX, USA.
authors.forename: Justine
authors.initials: J
authors.lastname: Johnson
authors.affiliation: Texas Tech University Health Sciences Center, Department of Neurology, 3601 4th Street, STOP 8321, Lubbock 79430-8321, TX, USA.
authors.forename: Pavis
authors.initials: P
authors.lastname: Laengvejkal
authors.affiliation: Texas Tech University Health Sciences Center, Department of Neurology, 3601 4th Street, STOP 8321, Lubbock 79430-8321, TX, USA.
authors.forename: John
authors.initials: J
authors.lastname: DeToledo
keywords: Complication; Encephalopathy; Hyperammonemia; Topiramate