title: Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ-Fe2O3 Phase.
abstract: Pure and highly crystalline γ-Fe2O3 nanocrystals (NCs) are obtained when hydrolysis and oxidation of a Fe(II) organometallic precursor are performed in successive steps. Their synthesis in pure alkylamine leads to NCs of about 6 nm. In aqueous solutions of poly(vinyl)pyrrolidone, such pristine NCs form aggregates of about 150 nm that exhibit a high transversal relaxivity (r2 =466 mM(-1) s(-1)) about four times higher than that of a commercial Feridex magnetic resonance imaging (MRI) contrast agent. Consequently, they provide a significant decrease in the NMR signal at very short echo time (8 ms), which is of paramount importance in clinical practice because of the reduced duration of MRI measurements.
authors.affiliation: Laboratoire de Chimie de Coordination, LCC, CNRS, UPR 8241, 205 route de Narbonne, 31077 Toulouse (France).|Institut des Sciences Chimiques de Rennes - UMR 6226, CNRS-Université Rennes I, 263 Avenue du General Leclerc, 35042 Rennes Cedex (France).
authors.forename: Gérald
authors.initials: G
authors.lastname: Casterou
authors.affiliation: Laboratoire de Chimie de Coordination, LCC, CNRS, UPR 8241, 205 route de Narbonne, 31077 Toulouse (France).
authors.forename: Vincent
authors.initials: V
authors.lastname: Collière
authors.affiliation: d'Elaboration de Matériaux et d'Etudes Structurales, CEMES, CNRS, 29 rue Jeanne Marvig, 31055 Toulouse (France).
authors.forename: Pierre
authors.initials: P
authors.lastname: Lecante
authors.affiliation: Laboratoire de Chimie de Coordination, LCC, CNRS, UPR 8241, 205 route de Narbonne, 31077 Toulouse (France).
authors.forename: Yannick
authors.initials: Y
authors.lastname: Coppel
authors.affiliation: PRISM - Biosit CNRS UMS 3480, INSERM UMS 018, Rennes (France).
authors.forename: Pierre-Antoine
authors.initials: PA
authors.lastname: Eliat
authors.affiliation: Institut des Sciences Chimiques de Rennes - UMR 6226, CNRS-Université Rennes I, 263 Avenue du General Leclerc, 35042 Rennes Cedex (France). fabienne.gauffre@univ-rennes1.fr.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Gauffre
authors.affiliation: Laboratoire de Chimie de Coordination, LCC, CNRS, UPR 8241, 205 route de Narbonne, 31077 Toulouse (France). myrtil.kahn@lcc-toulouse.fr.
authors.forename: Myrtil L
authors.initials: ML
authors.lastname: Kahn
keywords: imaging agents; iron; magnetic properties; nanoparticles; polymers