title: Effects of Oral Administration of CrCl3 on the Contents of Ca, Mg, Mn, Fe, Cu, and Zn in the Liver, Kidney, and Heart of Chicken.
abstract: This study aimed to investigate the effects of oral administration of trivalent chromium on the contents of Ca, Mg, Mn, Fe, Cu, and Zn in the heart, liver, and kidney. Different levels of 1/8, 1/4, and 1/2 LD50 (LD50 = 5000 mg/kg body mass) CrCl3 milligrams per kilogram body mass daily were added into the water to establish the chronic poisoning model. Ca, Mg, Mn, Fe, Cu, and Zn were detected with the flame atomic absorption spectrometry in the organs exposed 14, 28, and 42 days to CrCl3, respectively. Results showed that Cr was accumulated in the heart, liver, and kidney significantly (P < 0.05) with extended time and dose. The contents of Ca and Fe increased, whereas those of Mg, Mn, Cu, and Zn decreased in the heart, liver, and kidney of each treated group, which had a dose- and time-dependent relationship, but the contents of Mg and Zn in the heart took on a fluctuated change. These particular observations were different from those in the control group. In conclusion, the oral administration of CrCl3 could change the contents of Ca, Mg, Mn, Fe, Cu, and Zn in the heart, liver, and kidney, which may cause disorders in the absorption and metabolism of the metal elements of chickens.
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, Shandong, 271018, China.
authors.forename: Yanhan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, Shandong, 271018, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Zhao
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, Shandong, 271018, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, Shandong, 271018, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong, 271018, China. liuyongxia666@163.com.
authors.forename: Yongxia
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Shandong Agricultural University, Tai'an, Shandong, 271018, China. Liujz@sdau.edu.cn.
authors.forename: Jianzhu
authors.initials: J
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000032:analysis; D002645:Chickens; D002712:Chlorides / Q000008:administration & dosage* / Q000494:pharmacology*; D002857:Chromium / Q000032:analysis; D017608:Chromium Compounds / Q000008:administration & dosage* / Q000494:pharmacology*; D003300:Copper / Q000032:analysis; D007501:Iron / Q000032:analysis; D007668:Kidney / Q000737:chemistry / Q000187:drug effects*; D008099:Liver / Q000737:chemistry / Q000187:drug effects*; D008274:Magnesium / Q000032:analysis; D008345:Manganese / Q000032:analysis; D008670:Metals / Q000032:analysis*; D009206:Myocardium / Q000737:chemistry*; D015032:Zinc / Q000032:analysis
chemical_list: D002712:Chlorides; D017608:Chromium Compounds; D008670:Metals; D002857:Chromium; D008345:Manganese; D003300:Copper; D007501:Iron; D008274:Magnesium; D015032:Zinc; C022990:chromic chloride; D002118:Calcium
keywords: Chicken; Damage; Oral; Trace element; Trivalent chromium