title: A Rare Haemoglobin Variant Identified as K Woolwich in a Pakistani Male.
abstract: Haemoglobin (Hb) K Woolwich is a rare Hb variant which was first described in a family from West Indies and its occurrence was later reported mainly in Black families from many African countries. We report a case of a young male who came for evaluation of anemia. His complete blood count showed hypochromic, microcytic anemia and his serum ferritin was low. Hb electrophoresis done as part of initial workup showed an abnormal band which moved faster than HbA. For further evaluation, Hb analysis by high performance liquid chromatography was subsequently performed and revealed Hb K Woolwich. This is a rare Hb variant recognized in Pakistani population for the first time through careful interpretation of the chromatographic behavior of the Hb.
authors.affiliation: Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi.
authors.forename: Sidra Asad
authors.initials: SA
authors.lastname: Ali
authors.affiliation: Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi.
authors.forename: Natasha
authors.initials: N
authors.lastname: Ali
mesh_terms: D000328:Adult; D000747:Anemia, Hypochromic / Q000097:blood* / Q000209:etiology; D044466:Asian People; D001797:Blood Protein Electrophoresis; D002851:Chromatography, High Pressure Liquid; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000032:analysis*; D006455:Hemoglobins, Abnormal; D006801:Humans; D008297:Male
chemical_list: D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D005293:Ferritins; C050153:hemoglobin K Woolwich