title: On the mechanism of erythrocyte hemolysis induced by photooxidized psoralen.
abstract: Contemporary concepts on a possible mechanism of erythrocyte hemolysis induced by photooxidized psoralen - the medicinal photosensitizing furocoumarin - are reviewed. The hypothesis on the mechanochemical mechanism of hemolysis is considered in view of recent data on photoinduced aggregation in photooxidized psoralen solutions. Appropriate chemical structures of photoproduct hemolysins and aggregating photoproducts are discussed.
authors.affiliation: Pirogov Russian National Research Medical University, Department of Physics and Mathematics, Moscow, 117997, Russia. frost88.07@mail.ru.
authors.forename: E V
authors.initials: EV
authors.lastname: Nevezhin
authors.forename: N V
authors.initials: NV
authors.lastname: Vlasova
authors.forename: I A
authors.initials: IA
authors.lastname: Pyatnitskiy
authors.forename: E P
authors.initials: EP
authors.lastname: Lysenko
authors.forename: M V
authors.initials: MV
authors.lastname: Malakhov
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000473:pathology; D011564:Furocoumarins / Q000494:pharmacology*; D006460:Hemolysin Proteins / Q000097:blood; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D010084:Oxidation-Reduction; D017319:Photosensitizing Agents / Q000494:pharmacology*
chemical_list: D011564:Furocoumarins; D006460:Hemolysin Proteins; D017319:Photosensitizing Agents