title: Synthetic Approach to Glycopolymer Base Nanoparticle Gold(I) Conjugate: A New Generation of Therapeutic Agents.
abstract: Advances in nanotechnology have led to the fabrication of nano-constructs of organic or inorganic origins with well-defined structures, surface properties, and can be made to respond to physical or chemical stimuli. These nano-constructs can provide a shift in the way diagnostic and therapeutic drugs are delivered to achieve target specificity and increased retention of therapeutic doses for considerable improvement in the overall treatment of the tumors. In this case we describe here a synthetic approach to glycopolymer base nanoparticle gold(I) conjugate for cancer therapy.
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, 9107-116 Street, Edmonton, AB, Canada, T6G 2V4.|Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa.
authors.forename: Christian K
authors.initials: CK
authors.lastname: Adokoh
authors.affiliation: Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa.
authors.forename: James
authors.initials: J
authors.lastname: Darkwa
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, 9107-116 Street, Edmonton, AB, Canada, T6G 2V4. narain@ualberta.ca.
authors.forename: Ravin
authors.initials: R
authors.lastname: Narain
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000494:pharmacology; D006046:Gold; D053768:Metal Nanoparticles / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D006001:Glycoconjugates; D011108:Polymers; D006046:Gold
keywords: Glyconanoparticles; Glycopolymer; Gold(I) triphenylphosphine; Target specificity