title: Time-Dependent Computed Tomographic Perfusion Thresholds for Patients With Acute Ischemic Stroke.
abstract: OBJECTIVE
  Among patients with acute ischemic stroke, we determine computed tomographic perfusion (CTP) thresholds associated with follow-up infarction at different stroke onset-to-CTP and CTP-to-reperfusion times.
  
  
  METHODS
  Acute ischemic stroke patients with occlusion on computed tomographic angiography were acutely imaged with CTP. Noncontrast computed tomography and magnectic resonance diffusion-weighted imaging between 24 and 48 hours were used to delineate follow-up infarction. Reperfusion was assessed on conventional angiogram or 4-hour repeat computed tomographic angiography. Tmax, cerebral blood flow, and cerebral blood volume derived from delay-insensitive CTP postprocessing were analyzed using receiver-operator characteristic curves to derive optimal thresholds for combined patient data (pooled analysis) and individual patients (patient-level analysis) based on time from stroke onset-to-CTP and CTP-to-reperfusion. One-way ANOVA and locally weighted scatterplot smoothing regression was used to test whether the derived optimal CTP thresholds were different by time.
  
  
  RESULTS
  One hundred and thirty-two patients were included. Tmax thresholds of >16.2 and >15.8 s and absolute cerebral blood flow thresholds of <8.9 and <7.4 mL·min(-1)·100 g(-1) were associated with infarct if reperfused <90 min from CTP with onset <180 min. The discriminative ability of cerebral blood volume was modest. No statistically significant relationship was noted between stroke onset-to-CTP time and the optimal CTP thresholds for all parameters based on discrete or continuous time analysis (P>0.05). A statistically significant relationship existed between CTP-to-reperfusion time and the optimal thresholds for cerebral blood flow (P<0.001; r=0.59 and 0.77 for gray and white matter, respectively) and Tmax (P<0.001; r=-0.68 and -0.60 for gray and white matter, respectively) parameters.
  
  
  CONCLUSIONS
  Optimal CTP thresholds associated with follow-up infarction depend on time from imaging to reperfusion.
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Christopher D
authors.initials: CD
authors.lastname: d'Esterre
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Mari E
authors.initials: ME
authors.lastname: Boesen
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Ahn
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Pooneh
authors.initials: P
authors.lastname: Pordeli
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Mohamed
authors.initials: M
authors.lastname: Najm
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Priyanka
authors.initials: P
authors.lastname: Minhas
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Paniz
authors.initials: P
authors.lastname: Davari
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Enrico
authors.initials: E
authors.lastname: Fainardi
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Marta
authors.initials: M
authors.lastname: Rubiera
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Khaw
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Andrea
authors.initials: A
authors.lastname: Zini
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Richard
authors.initials: R
authors.lastname: Frayne
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hill
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Demchuk
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Tolulope T
authors.initials: TT
authors.lastname: Sajobi
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Nils D
authors.initials: ND
authors.lastname: Forkert
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Mayank
authors.initials: M
authors.lastname: Goyal
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.).
authors.forename: Ting Y
authors.initials: TY
authors.lastname: Lee
authors.affiliation: From the Calgary Stroke Program, Department of Clinical Neurosciences (C.D.d'E., S.H.A., P.P., M.N., P.M., P.D., M.D.H., A.M.D., T.T.S., M.G., B.K.M.), Department of Radiology (C.D.d'E., R.F., M.D.H., A.M.D., N.D.F., M.G., T.Y.L., B.K.M.), Department of Community Health Sciences (P.P., M.D.H., T.T.S., B.K.M.), and Biomedical Engineering Graduate Program (M.E.B., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, Calgary, Alberta, Canada (R.F., M.D.H., A.M.D., N.D.F., M.G., B.K.M.); Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, Alberta, Canada (C.D.d'E., M.E.B., S.H.A., M.N., R.F., M.D.H., A.M.D., M.G., B.K.M.); Department of Neurology, Chosun University School of Medicine, Gwang Ju, South Korea (S.H.A.); Department of Neurosciences and Rehabilitation, University Hospital, Ferrara, Italy (E.F.); Department of Neurology, Hospital Vall d'Hebron, Ps. Vall d'Hebron, Barcelona, Spain (M.R.); Lawson Health Research Institute and Robarts Research Institute, London, Ontario, Canada (T.Y.L.); Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada (A.V.K.); and Department of Neurosciences, University Hospital, Modena, Italy (A.Z.). docbijoymenon@gmail.com.
authors.forename: Bijoy K
authors.initials: BK
authors.lastname: Menon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*; D011446:Prospective Studies; D020521:Stroke / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: CT; acute ischemic stroke; endovascular therapy; infarction; perfusion