title: [The expression and clinical significance of hyaluronan synthase in nasal polyps].
abstract: OBJECTIVE
  To study the expression of hyaluronan synthasel-3 (HAS1-3) in nasal polyps, and discuss their clinical significance.
  
  
  METHODS
  The expression of HA, HAS1, HAS2 and HAS3 in nasal polyps group (25 cases) and inferior turbinate group (15 cases) was detected by immunohistochemistry and semi-quantitative RT-PCR.
  
  
  RESULTS
  Compared with the control, the expression of HA, HAS1 and HAS3 was higher in nasal polyps (P<0. 05), while there was no significant difference in HAS2 expression (P>0. 05).
  
  
  CONCLUSIONS
  The increase of HASI and HAS3 expression may be the main cause of the excessive deposition of HA in nasal polyps, which may play an important role in the pathogenic process of nasal polyps, and become a potential target for therapy of nasal polyps.
authors.forename: Shouhou
authors.initials: S
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Yu
authors.forename: Zhibiao
authors.initials: Z
authors.lastname: Liu
mesh_terms: D014453:Glucuronosyltransferase / Q000378:metabolism*; D006801:Humans; D000076002:Hyaluronan Synthases; D006820:Hyaluronic Acid; D007150:Immunohistochemistry; D009298:Nasal Polyps / Q000201:enzymology*
chemical_list: D006820:Hyaluronic Acid; D014453:Glucuronosyltransferase; C523794:HAS1 protein, human; C101754:HAS2 protein, human; C105458:HAS3 protein, human; D000076002:Hyaluronan Synthases