title: Nonconventional three-finger toxin BMLCL from krait Bungarus multicinctus venom with high affinity interacts with nicotinic acetylcholine receptors.
abstract: Nonconventional three-finger toxin BMLCL was isolated from B. multicinctus venom, and its interaction with different subtypes of nicotinic acetylcholine receptor (nAChR) was studied. It was found that BMLCL is able to interact with high efficiency with both α7 and muscle type nAChRs.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia. utkin@mx.ibch.ru.|The National University of Science and Technology MISiS, Moscow, Russia. utkin@mx.ibch.ru.
authors.forename: Yu N
authors.initials: YN
authors.lastname: Utkin
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.|Syneuro Ltd., Moscow, Russia.
authors.forename: I E
authors.initials: IE
authors.lastname: Kasheverov
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.|Syneuro Ltd., Moscow, Russia.
authors.forename: D S
authors.initials: DS
authors.lastname: Kudryavtsev
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Andreeva
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Starkov
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
authors.forename: R H
authors.initials: RH
authors.lastname: Ziganshin
authors.affiliation: The National University of Science and Technology MISiS, Moscow, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Kuznetsov
authors.affiliation: Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
authors.forename: Hoang Ngoc
authors.initials: HN
authors.lastname: Anh
authors.affiliation: Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
authors.forename: Nguyen Thi Thanh
authors.initials: NT
authors.lastname: Thao
authors.affiliation: Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
authors.forename: Nguyen Cuu
authors.initials: NC
authors.lastname: Khoa
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Tsetlin
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D001048:Aplysia; D002038:Bungarotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D017838:Bungarus; D018678:Cholinergic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D003039:Cobra Neurotoxin Proteins / Q000494:pharmacology; D006801:Humans; D008195:Lymnaea; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008969:Molecular Sequence Data; D009865:Oocytes; D051381:Rats; D011978:Receptors, Nicotinic / Q000378:metabolism*; D030162:Reptilian Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D017386:Sequence Homology, Amino Acid; D014981:Xenopus
chemical_list: C120014:BMLCL protein, Bungarus multicinctus multicinctus; D002038:Bungarotoxins; D018678:Cholinergic Agents; D003039:Cobra Neurotoxin Proteins; D011978:Receptors, Nicotinic; D030162:Reptilian Proteins; C025154:alpha-cobratoxin; D000109:Acetylcholine