title: Directed meta-Selective Bromination of Arenes with Ruthenium Catalysts.
abstract: A Ru-catalyzed direct CH activation/meta-bromination of arenes bearing pyridyl, pyrimidyl, and pyrazolyl directing groups has been developed. A series of bromo aryl pyridines and pyrimidines have been synthesized, and further coupling reactions have also been demonstrated for a number of representative functionalized arenes. Preliminary mechanistic studies have revealed that this reaction may proceed through radical-mediated bromination when NBS is utilized as the bromine source. This type of transformation has opened up a new direction for the radical non-ipso functionalization of metal with regard to future CH activation development that would allow the remote functionalization of aromatic systems.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072 (China).|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072 (China).|Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency (China).
authors.forename: Qingzhen
authors.initials: Q
authors.lastname: Yu
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072 (China).|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072 (China).|Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency (China).
authors.forename: Le'an
authors.initials: L
authors.lastname: Hu
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072 (China).|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072 (China).|Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency (China).
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072 (China).|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072 (China).|Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency (China).
authors.forename: Shasha
authors.initials: S
authors.lastname: Zheng
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072 (China). jhuang@tju.edu.cn.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072 (China). jhuang@tju.edu.cn.|Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency (China). jhuang@tju.edu.cn.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Huang
keywords: CH activation; bromination; meta-selective; radical processes