title: Quantum-dots-encoded-microbeads based molecularly imprinted polymer.
abstract: Quantum dots encoded microbeads have various advantages such as large surface area, superb optical properties and the ability of multiplexing. Molecularly imprinted polymer that can mimic the natural recognition entities has high affinity and selectivity for the specific analyte. Here, the concept of utilizing the quantum dots encoded microbeads as the supporting material and the polydopamine as the functional monomer to form the core-shell molecular imprinted polymer was proposed for the first time. The resulted imprinted polymer can provide various merits: polymerization can complete in aqueous environment; fabrication procedure is facile and universal; the obvious economic advantage; the thickness of the imprinting layer is highly controllable; polydopamine coating can improve the biocompatibility of the quantum dot encoded microbeads. The rabbit IgG binding and flow cytometer experiment result showed the distinct advantages of this strategy: cost-saving, facile and fast preparation procedure. Most importantly, the ability for the multichannel detection, which makes the imprinted polydopamine modified encoded-beads very attractive in protein pre-concentration, recognition, separation and biosensing.
authors.affiliation: Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of optical imaging and sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China; Department of Physics, Tsinghua University, Beijing 100084, China.
authors.forename: Yixi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Green Chemistry and Energy, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.
authors.forename: Le
authors.initials: L
authors.lastname: Liu
authors.affiliation: Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of optical imaging and sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China; Department of Physics, Tsinghua University, Beijing 100084, China. Electronic address: heyh@sz.tsinghua.edu.cn.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: He
authors.affiliation: Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of optical imaging and sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China; Department of Physics, Tsinghua University, Beijing 100084, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: He
authors.affiliation: Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of optical imaging and sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China; Department of Physics, Tsinghua University, Beijing 100084, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
mesh_terms: D007211:Indoles / Q000737:chemistry*; D008422:Materials Testing; D008863:Microspheres; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D045663:Quantum Dots; D013194:Staining and Labeling / Q000379:methods
chemical_list: D007211:Indoles; D011108:Polymers; C568283:polydopamine
keywords: Molecular imprinting technique; Polydopamine; Quantum dots