title: Bone Tissue Engineering Challenges in Oral & Maxillofacial Surgery.
abstract: Over the past decades, there has been a substantial amount of innovation and research into tissue engineering and regenerative approaches for the craniofacial region. This highly complex area presents many unique challenges for tissue engineers. Recent research indicates that various forms of implantable biodegradable scaffolds may play a beneficial role in the clinical treatment of craniofacial pathological conditions. Additionally, the direct delivery of bioactive molecules may further increase de novo bone formation. While these strategies offer an exciting glimpse into potential future treatments, there are several challenges that still must be overcome. In this chapter, we will highlight both current surgical approaches for craniofacial reconstruction and recent advances within the field of bone tissue engineering. The clinical challenges and limitations of these strategies will help contextualize and inform future craniofacial tissue engineering strategies.
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX, USA.
authors.forename: Brandon T
authors.initials: BT
authors.lastname: Smith
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Shum
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Wong
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX, USA.|Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Mikos
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA. simon.young@uth.tmc.edu.
authors.forename: Simon
authors.initials: S
authors.lastname: Young
mesh_terms: D001847:Bone Diseases / Q000503:physiopathology / Q000601:surgery; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D018786:Bone Substitutes / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D019767:Maxillofacial Abnormalities / Q000503:physiopathology / Q000601:surgery; D019647:Oral Surgical Procedures / Q000379:methods* / Q000639:trends; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes; D036341:Intercellular Signaling Peptides and Proteins
keywords: Bone regeneration; Bone scaffolds; Growth factor; Maxilofacial reconstruction; Stem cells; Tissue engineering