title: One new 19-nor cucurbitane-type triterpenoid from the stems of Momordica charantia.
abstract: One new 19-nor cucurbitane-type triterpenoid (3β,9β,25-trihydroxy-7β-methoxy-19-nor-cucurbita-5,23(E)-diene) (1), together with other six known cucurbitane-type triterpenoids (2-7), were isolated from the stems of Momordica charantia L. The chemical structure of 1 was elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY and ROESY), MS experiments. Using MTT assay, compound 1 exhibited weak cytotoxicity against HL-60, A-549, and SK-BR-3 cell lines with the IC50 values at 27.3, 32.7 and 26.6 μM, respectively.
authors.affiliation: a Life school of Science and Technology , Henan Institute of Science and Technology , Xinxiang , China.
authors.forename: Yong-chao
authors.initials: YC
authors.lastname: Li
authors.affiliation: a Life school of Science and Technology , Henan Institute of Science and Technology , Xinxiang , China.
authors.forename: Xin-juan
authors.initials: XJ
authors.lastname: Xu
authors.affiliation: a Life school of Science and Technology , Henan Institute of Science and Technology , Xinxiang , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: b School of Food Science , Henan Institute of Science and Technology , Xinxiang , China.
authors.forename: Xing-gang
authors.initials: XG
authors.lastname: Wu
authors.affiliation: a Life school of Science and Technology , Henan Institute of Science and Technology , Xinxiang , China.
authors.forename: Qing-yun
authors.initials: QY
authors.lastname: Fu
mesh_terms: D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029777:Momordica charantia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: C000612024:3beta,9beta,25-trihydroxy-7beta-methoxy-19-nor-cucurbita-5,23(E)-diene; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; C514277:cucurbitane
keywords: 19-nor cucurbitane-type triterpenoid; Momordica charantia L; cytotoxicity