title: The Multiple Roles of Microrna-223 in Regulating Bone Metabolism.
abstract: Bone metabolism is a lifelong process for maintaining skeletal system homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts. Aberrant differentiation of osteoclasts and osteoblasts leads to imbalanced bone metabolism, resulting in ossification and osteolysis diseases. MicroRNAs (miRNAs) are pivotal factors in regulating bone metabolism via post-transcriptional inhibition of target genes. Recent studies have revealed that miR-223 exerts multiple effects on bone metabolism, especially in the processes of osteoclast and osteoblasts differentiation. In this review, we highlight the roles of miR-223 during the processes of osteoclast and osteoblast differentiation, as well as the potential clinical applications of miR-223 in bone metabolism disorders.
authors.affiliation: Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China. yong.xie301@gmail.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China. zhanglihai@gmail.com.
authors.forename: Lihai
authors.initials: L
authors.lastname: Zhang
authors.affiliation: National Key Laboratory of Medical Molecular Biology, Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China. gaoyanpan@gmail.com.
authors.forename: Yanpan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: National Key Laboratory of Medical Molecular Biology, Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China. wei.ge@chem.ox.ac.uk.
authors.forename: Wei
authors.initials: W
authors.lastname: Ge
authors.affiliation: Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China. pftang301@126.com.
authors.forename: Peifu
authors.initials: P
authors.lastname: Tang
mesh_terms: D000818:Animals; D001846:Bone Development; D016723:Bone Remodeling; D002454:Cell Differentiation; D015870:Gene Expression; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D051839:NFI Transcription Factors / Q000235:genetics / Q000378:metabolism; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D034622:RNA Interference; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D051839:NFI Transcription Factors; C525067:MIR223, human; C497592:NFIA protein, human
keywords: bone metabolism; miR-223; osteoblast; osteoclast