title: [Expression level of p53 in Tumor Tissue of Patients with Acute Leukemia and Its Clinical Significance].
abstract: OBJECTIVE
  To study the expression level of p53 in tumor tissue of patients with acute leukemia (AL) and its clinical significance.
  
  
  METHODS
  From April 2013 to April 2015, 80 patients with AL in our hospital were chosen as leukemia group, at the same time, 50 patients with non-hematologic diseases were chosen as control group. All the patients were detected by bone marrow smear mean and p53 staining. The positive rate of p53 and staining score were compared between 2 groups. The clinical data of leukemia group were collected, and the correlation of clinical features with p53 expression was analyzed.
  
  
  RESULTS
  In the control group, the positive rate of p53 was 6.00%, the staining score was (0.2 ± 0.1); in the leukemia group, the positive rate of p53 was 73.75%, the staining score was (1.9 ± 0.4), the difference was statistically significant (P < 0.05). The expression of p53 significantly correlated with the blood routine indicators, clinical manifestation, multiple infiltration and curative effects (P < 0.05), and the p53 expression not correlated statistically with the sex, age, anamnesis, family history (P > 0.05).
  
  
  CONCLUSIONS
  Compared with the patients with non-hematologic diseases, the expression level of p53 in the AL patients increases significantly, the p53 expression correlates significantly with the blood routine indicators, clinical manifestation and curative effect of the patients.
authors.affiliation: Faculty of Clinical Laboratorial Examination, Baotou Medical College, Baotou 014040, Inner Mongolia Autonomous Region, China. E-mail: slt-2008@163.com.
authors.forename: Lian-Tao
authors.initials: LT
authors.lastname: Sun
authors.affiliation: Department of Laboratorial Examination, The Inner Mongolia Autonomous Region People's Hospital, Hohhot 010017, Inner Mongolia Autonomous Region, China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Xiao
mesh_terms: D000208:Acute Disease; D016022:Case-Control Studies; D006801:Humans; D007938:Leukemia / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53