title: [To the question of pathophysiological fundamentals of endocrine system functioning in patients with a first psychotic episode].
abstract: OBJECTIVE
  To study the characteristics of prolactin secretion in patients with a first psychotic episode (FPE) with regard to disease severity, gender and patient's neuromediator system state.
  
  
  METHODS
  Author studied 76 patients with schizophrenic spectrum disorders and 34 normals (control group).
  
  
  CONCLUSIONS
  There was a significant negative sex-related correlation between the severity of psychopathologic symptoms and plasma prolactin levels. Based on the results author attempted to explain the hormonal disbalance in the patients with FPE taking into account the state of monoaminergic mediator systems in patients.
authors.affiliation: Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Moscow Research Institute of Psychiatry, Moscow.
authors.forename: L N
authors.initials: LN
authors.lastname: Gorobets
mesh_terms: D000293:Adolescent; D000328:Adult; D004703:Endocrine System / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011618:Psychotic Disorders / Q000097:blood / Q000503:physiopathology*; D012559:Schizophrenia / Q000097:blood / Q000503:physiopathology*; D012737:Sex Factors; D055815:Young Adult
chemical_list: D011388:Prolactin