title: Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer.
abstract: We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were collected between May 2012 and May 2014. The SNP genotyping of IL-17A rs2275913G>A and rs3748067C>T and IL-17F rs763780 T>C was performed using the Sequenom MassARRAY platform (Sequenom, San Diego, CA, USA) according to the manufacturer instructions. By conditional regression analysis, individuals carrying the AA and the GA+AA genotypes of rs2275913G>A were correlated with an elevated risk of gastric cancer when compared with those carrying the GG genotype, and the adjusted ORs (95%CIs) were 2.05 (1.13-3.76) for the AA genotype and 1.45 (1.03-2.08) for the GA+AA genotype. In conclusion, our results suggest that the IL-17A rs3748067C>T and IL-17F rs763780 T>C polymorphisms play an important role in the risk of gastric cancer in a Chinese population.
authors.affiliation: Department of Emergency, Zhengzhou People's Hospital, Zhengzhou, China.
authors.forename: W T
authors.initials: WT
authors.lastname: Qi
authors.affiliation: Department of Internal Medicine, Zhengzhou Straight Authority Hospital, Zhengzhou, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Gao
authors.affiliation: Department of Emergency, Zhengzhou People's Hospital, Zhengzhou, China.
authors.forename: S S
authors.initials: SS
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D020381:Interleukin-17