title: Controlled-Release System of Small Molecules Triggered by the Photothermal Effect of Polypyrrole.
abstract: In this paper, a novel synthesis of polyethylene glycol (PEG)-modified polypyrrole (PPy) nanomaterials is demonstrated by combining reversible addition-fragmentation chain transfer polymerization and oxidative polymerization. Dye molecules with a heat-labile linker are used as a model drug and covalently anchored onto the PEGlated PPy nanomaterials via "click chemistry." The strong absorption of such PPy nanomaterials in the near-infrared region endows the system excellent photothermal effect, which can be used not only as efficient photothermal agents for photothermal therapy but also good controllers of a drug-release system by retro D-A reaction.
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.
authors.forename: Linfeng
authors.initials: L
authors.lastname: Xiong
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Liao
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.|State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
mesh_terms: D057930:Click Chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D065546:Drug Liberation; D005456:Fluorescent Dyes / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D007259:Infrared Rays; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011721:Pyrenes; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D011108:Polymers; D011721:Pyrenes; D011758:Pyrroles; C067635:polypyrrole; D011092:Polyethylene Glycols; D006046:Gold; C030984:pyrene
keywords: NIR light; PPy nanoparticles; controlled-release; photothermal effect; retro D-A reaction