title: [Vitamin D supplementation for everybody everytime?].
abstract: Only few foods contain vitamin D in higher concentrations. Therefore, the main source of vitamin D is the dermal synthesis under the influence of UVB-light. By enzymatic hydroxylation vitamin D is converted to 25-hydroxy-vitamin D and finally to the active hormone 1,25-dihydroxy-vitamin D, which plays an important role in calcium- and bone metabolism. Vitamin D-deficiency can result in demineralisation of the bone. The vitamin D-receptor is expressed by all nucleated cells of the body and vitamin D regulates many cellular functions. Sublinical vitamin D-deficiency is common even in the normal population resulting in a risk situation for at least osteoporosis and falls in older people. This is the reason for fortification of food in some countries by vitamin D. Also in Germany vitamin D-deficiency can be detected in many people leading to the question: is vitamin D supplementation necessary for everyone?
authors.affiliation: Medizinische Klinik I, Universität zu Lübeck.
authors.forename: Jan
authors.initials: J
authors.lastname: Kramer
mesh_terms: D000328:Adult; D000368:Aged; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use; D014808:Vitamin D Deficiency
chemical_list: D014807:Vitamin D