title: TRIM-NHL proteins in development and disease.
abstract: TRIM-NHL proteins are key regulators of developmental transitions, for example promoting differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells. Abnormalities in these proteins have been also associated with human diseases, particularly affecting muscular and neuronal functions, making them potential targets for therapeutic intervention. The purpose of this review is to provide a systematic and comprehensive summary on the most studied TRIM-NHL proteins, highlighting examples where connections were established between structural features, molecular functions and biological outcomes.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Cristina
authors.initials: C
authors.lastname: Tocchini
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland. Electronic address: rafal.ciosk@fmi.ch.
authors.forename: Rafal
authors.initials: R
authors.lastname: Ciosk
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000145:classification / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009024:Morphogenesis / Q000235:genetics*; D009154:Mutation; D009687:Nuclear Proteins / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D014157:Transcription Factors / Q000145:classification / Q000235:genetics*; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases / Q000145:classification / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; C400022:NARF protein, human; D009687:Nuclear Proteins; C426543:TRIM3 protein, human; D014157:Transcription Factors; D000070584:Tripartite Motif Proteins; C094027:TRIM32 protein, human; C584142:TRIM71 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: Bardet-Biedl syndrome; Brat; LIN-41; Limb girdle muscular dystrophy 2H; Mei-P26; NHL; Sarcotubular myopathy; TRIM; TRIM32; TRIM71