title: Stereoselective Construction of Bridged trans-aza-Bicyclo[7/6,3/2,1]alkenyl Imines through Ring Expansion aza-Cope Rearrangement.
abstract: A highly stereoselective method for efficient synthesis of unprecedented bridged bicyclo[7/6,3/2,1]alkenyl amidines is described using cyclic N-allyl-aminoalkyne as a substrate. A ketenimine formation/cyclization/aza-Cope rearrangement cascade proceeds either with or without the aid of external DIPEA depending on substrate basicity. Fused bicycloamidines are also obtained via the same protocol using different N-allyl cyclic aminoalkynes.
authors.affiliation: School of Pharmaceutical Engineering and Life Science, Changzhou University , Changzhou, Jiangsu Province 213164, China.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Shen
authors.affiliation: School of Pharmaceutical Engineering and Life Science, Changzhou University , Changzhou, Jiangsu Province 213164, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Engineering and Life Science, Changzhou University , Changzhou, Jiangsu Province 213164, China.
authors.forename: Chu-Han
authors.initials: CH
authors.lastname: Sun
authors.affiliation: School of Pharmaceutical Engineering and Life Science, Changzhou University , Changzhou, Jiangsu Province 213164, China.
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Xua