title: Quantitative Indexes of Leukocytes in Spontaneously Hypertensive Rats During Various Periods of Arterial Hypertension Development.
abstract: SHR rats were examined in the period before arterial hypertension development (5th week), during the increase in BP (6th-10th weeks), and under conditions of constantly elevated BP (11th-12th weeks). The total number of leukocytes did not differ in SHR and normotensive WKY rats. However, the relative number of lymphocytes and monocytes was shown to differ in various periods of arterial hypertension development. Our results suggest that white blood cells (primarily lymphocytes) are involved in the development of arterial hypertension.
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. nbp2001@mail.ru.
authors.forename: O I
authors.initials: OI
authors.lastname: Aliev
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Anishchenko
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Sidekhmenova
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Shamanaev
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Fedorova
authors.affiliation: Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
mesh_terms: D000818:Animals; D001794:Blood Pressure; D018450:Disease Progression; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D007958:Leukocyte Count; D007962:Leukocytes / Q000473:pathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
keywords: SHR rats; WKY rats; arterial hypertension; blood pressure; leukocytes