title: ME20-S as a Potential Biomarker for the Evaluation of Uveal Melanoma.
abstract: OBJECTIVE
  We previously identified the presence of the melanocyte-specific secreted (ME20-S) glycoprotein in secretomes of uveal melanoma (UM) cultures. The aim of this study was to test for the presence and levels of ME20-S in the serum of patients with choroidal nevi and UM and correlate these levels with individual clinical data.
  
  
  METHODS
  Serum ME20-S levels were determined by ELISA in 111 patients distributed into four categories (53 choroidal nevi, 30 untreated UM, 11 10-year disease-free [DF] UM, 17 hepatic metastatic UM) and 32 age- and sex-matched controls. ME20-S levels were correlated with individual clinical data.
  
  
  RESULTS
  The UM and the metastatic groups showed significantly higher levels of serum ME20-S than the other groups (P < 0.001). ME20-S levels in the DF patients did not differ from those in the control group. In addition, log-transformed serum ME20-S levels showed a positive correlation with the thickness of the lesion mass in UM patients (regression coefficient 0.0689, 95% confidence interval 0.0689-0.1123, R2 = 27.1%).
  
  
  CONCLUSIONS
  Elevated ME20-S serum levels are associated with tumor size and advanced stages of UM while low levels are characteristic of DF patients. ME20-S might be a promising serum marker for UM and useful for monitoring metastatic disease.
authors.affiliation: Ocular Oncology Unit Service of Ophthalmology, Complexo Hospitalario Universitario de Santiago, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Bande
authors.affiliation: Ocular Oncology Unit Service of Ophthalmology, Complexo Hospitalario Universitario de Santiago, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Santiago
authors.affiliation: Ocular Oncology Unit Service of Ophthalmology, Complexo Hospitalario Universitario de Santiago, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Purificacion
authors.initials: P
authors.lastname: Mera
authors.affiliation: Medical Oncology Department, Catalan Institute of Oncology, Barcelona, Spain.
authors.forename: Josep María
authors.initials: JM
authors.lastname: Piulats
authors.affiliation: Ocular Oncology Unit Service of Ophthalmology, Complexo Hospitalario Universitario de Santiago, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: María Jose
authors.initials: MJ
authors.lastname: Blanco
authors.affiliation: Department of Statistics and Operational Research, University of Vigo, Vigo, Spain.
authors.forename: María Xosé
authors.initials: MX
authors.lastname: Rodríguez-Álvarez
authors.affiliation: Ocular Oncology Unit Service of Ophthalmology, Complexo Hospitalario Universitario de Santiago, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Carmela
authors.initials: C
authors.lastname: Capeans
authors.affiliation: Ocular Oncology Unit Service of Ophthalmology, Complexo Hospitalario Universitario de Santiago, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Piñeiro
authors.affiliation: Grupo Obesidómica, Instituto de Investigación Sanitaria de Santiago (IDIS), Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Pardo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood*; D008875:Middle Aged; D012189:Retrospective Studies; D014604:Uveal Neoplasms / Q000097:blood*; D055815:Young Adult; D058951:gp100 Melanoma Antigen / Q000097:blood*; D000098943:Uveal Melanoma
chemical_list: D014408:Biomarkers, Tumor; C548637:PMEL protein, human; D058951:gp100 Melanoma Antigen