title: Synthetic Approach to Biotinylated Glyco-Functionalized Quantum Dots: A New Fluorescent Probes for Biomedical Applications.
abstract: Technological advances that allow deeper penetration in live tissues, such as the development of confocal and the generation of ever-new fluorophores that facilitate bright labeling of cells and tissue components have made imaging of vertebrate model organisms efficient and highly informative. Recently, high luminescence, single-excitation narrow emission, low photo bleaching properties, and low toxicity of high-quality water-soluble QDs have attracted attention for in vivo labeling/imaging of cells. Herein we describe a synthetic approach to biotinylated glycopolymer functionalized quantum dots, with special emphasis on the development of high-quality water-soluble and bioactive QDs with low toxicity for fluorescent probes in biomedical applications.
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, 9107-116 Street, Edmonton, AB, T6G 2V4, Canada.|Department of Chemistry, University of Johannesburg, 524, Auckland Park, 2006, South Africa.
authors.forename: Christian K
authors.initials: CK
authors.lastname: Adokoh
authors.affiliation: Department of Chemistry, University of Johannesburg, 524, Auckland Park, 2006, South Africa.
authors.forename: James
authors.initials: J
authors.lastname: Darkwa
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, 9107-116 Street, Edmonton, AB, T6G 2V4, Canada. narain@ualberta.ca.
authors.forename: Ravin
authors.initials: R
authors.lastname: Narain
mesh_terms: D019921:Biotinylation; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D006001:Glycoconjugates
keywords: Biotin; Biotinylated glycopolymers; Fluorescent probes; Quantum dot s