title: Antioxidant Activity of Novel Fused Heterocyclic Compounds Derived from Tetrahydropyrimidine Derivative.
abstract: 6-(Benzo[d][1,3]dioxol-5-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile has been utilized for synthesis of the fused heterocyclic compounds namely thiazolopyrimidines, tetrazolopyrimidine, pyrimidoquinazoline, pyrimidothiazolopyrimidine, pyrimidothiazolotriazine and pyrrolothiazolopyrimidine derivatives. The newly synthesized compounds were characterized by IR, (1)H-NMR, (13)C-NMR, and mass spectral data. Antioxidant activities of all synthesized compounds were investigated.
authors.affiliation: Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University.
authors.forename: Marwa Sayed
authors.initials: MS
authors.lastname: Salem
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Farhat
authors.forename: Asma Omar
authors.initials: AO
authors.lastname: Errayes
authors.forename: Hassan Mohamed Fawzy
authors.initials: HM
authors.lastname: Madkour
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: C581076:1,2,3,4-tetrahydropyrimidine-5-carbonitrile; D000975:Antioxidants; D006571:Heterocyclic Compounds; D009570:Nitriles; D011743:Pyrimidines