title: Advances in applications, metabolism, and biotechnological production of L-xylulose.
abstract: L-Xylulose is an intermediate in certain metabolic pathways and is classified as a rare sugar. It shows important physiological effects such as acting as an inhibitor of α-glucosidase and decreasing blood glucose, and it can be employed to produce other significant rare sugars, such as L-ribose and L-xylose which contribute to the production of antiviral drugs. Chemical synthesis of L-xylulose was performed, but it is difficult and low yielding. The biotransformation from xylitol to L-xylulose by xylitol 4-dehydrogenase was studied intensively. This review describes the occurrence of L-xylulose in certain metabolic pathways, its bioproduction, and application potential.
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Meng
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China. zhangtao9999@hotmail.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
authors.forename: Wanmeng
authors.initials: W
authors.lastname: Mu
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Miao
mesh_terms: D000998:Antiviral Agents; D001709:Biotechnology / Q000379:methods* / Q000639:trends; D001711:Biotransformation; D050542:D-Xylulose Reductase / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D012266:Ribose / Q000378:metabolism; D013401:Sugar Alcohol Dehydrogenases / Q000378:metabolism; D013402:Sugar Alcohols / Q000378:metabolism; D014993:Xylitol / Q000378:metabolism; D014994:Xylose / Q000378:metabolism; D014996:Xylulose / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D013402:Sugar Alcohols; D014996:Xylulose; D012266:Ribose; D014994:Xylose; D013401:Sugar Alcohol Dehydrogenases; D050542:D-Xylulose Reductase; D000520:alpha-Glucosidases; D005947:Glucose; D014993:Xylitol
keywords: Application potential; Bioproduction; L-Xylulose; Metabolic pathways; Rare sugar