title: D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts.
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Iannuzzi
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Borriello
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Carafa
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy; Institute of Genetics and Biophysics Adriano Buzzati-Traverso, IGB-CNR, Naples, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Altucci
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Vitiello
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Balestrieri
authors.affiliation: Department of Experimental Medicine, Second University of Naples, Naples, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ricci
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Irace
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy. Electronic address: ivana.sirangelo@unina2.it.
authors.forename: Ivana
authors.initials: I
authors.lastname: Sirangelo
mesh_terms: D000682:Amyloid / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D006031:Glycosylation; D006801:Humans; D007328:Insulin / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D041681:NIH 3T3 Cells; D066263:Protein Aggregation, Pathological / Q000378:metabolism*; D011487:Protein Conformation; D017382:Reactive Oxygen Species / Q000378:metabolism; D012266:Ribose / Q000378:metabolism*
chemical_list: D000682:Amyloid; D007328:Insulin; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D012266:Ribose
keywords: Amyloid aggregation; Apoptosis; D-ribose; Insulin glycation; NF-kB; ROS production