title: [Impacts on oxidative stress in the patients with cardiac valve replacement treated with electroacupuncture at Neiguan (PC 6)].
abstract: OBJECTIVE
  To observe the myocardial protective effect of electroacupuncture (EA) at Neiguan (PC 6) in the patients with valve replacement via extracorporeal circulation.
  
  
  METHODS
  Fifty patients of rheumatic cardiac disease planned for valve replacement were graded as II or III level according to America Society of Anesthesiologists (ASA) and were randomized into an observation group and a control group, 25 cases in each one. The same anesthesia and valve replacement via extracorporeal circulation were adopted in the patients of the two groups. In the observation group, 30 min before operation, EA was used to stimulate bilateral Neiguan (PC 6) till the end of operation. The venous blood was collected at 5 time points separately, named before aorta blockage (T1), 15 min after aorta open (T2), 30 min after aorta open (T3), 6 h after opening (T4) and 24 h after opening (T5). The concentrations of malondial dehyde (MDA), superoxide dismutase (SOD) and cardiac troponin 1 (cTnI) were determined in serum. The heart re-beating and the total dosage of vasoactive drugs after operation were recorded.
  
  
  RESULTS
  Compared with those before aorta blockage, MDA and cTnI at each time point of aorta open were all apparently increased in the patients of the two groups (all P<0. 05), and SOD was reduced apparently (P<0. 05). Compared with the control group, at the time points from T3 to T5 , MDA and cTnL were lower apparently in the observation group as compared with those in the control group (all P<0. 05) and SOD was higher than that in the control group (P<0. 05). The dosage of vasoactive drugs was reduced apparently (P<. 05).
  
  
  CONCLUSIONS
  EA at Neiguan (PC 6) alleviates oxidative stress injury and has the protective effect on ischemic reperfusion myocardium.
authors.forename: Fuguo
authors.initials: F
authors.lastname: Ma
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Huailong
authors.initials: H
authors.lastname: Chen
authors.forename: Lixin
authors.initials: L
authors.lastname: Sun
authors.forename: Mingshan
authors.initials: M
authors.lastname: Wang
mesh_terms: D015669:Acupuncture Points; D000328:Adult; D006348:Cardiac Surgical Procedures; D015671:Electroacupuncture; D005260:Female; D006351:Heart Valves / Q000601:surgery*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D012214:Rheumatic Heart Disease / Q000097:blood / Q000378:metabolism / Q000601:surgery / Q000628:therapy*; D013482:Superoxide Dismutase; D019210:Troponin I / Q000097:blood
chemical_list: D019210:Troponin I; D008315:Malondialdehyde; D013482:Superoxide Dismutase