title: Magnesium as a predictor of acute stent thrombosis in patients with ST-segment elevation myocardial infarction who underwent primary angioplasty.
abstract: BACKGROUND
  Although magnesium (Mg) has been proposed as a useful biomarker for predicting atherothrombosis, the association between Mg and acute stent thrombosis (ST) after primary percutaneous coronary intervention (p-PCI) for ST-segment elevation myocardial infarction (STEMI) has not yet been defined.
  
  
  OBJECTIVE
  We aimed to examine whether admission Mg levels predicted the development of acute ST after p-PCI in STEMI patients.
  
  
  RESULTS
  A total of 2633 patients with STEMI who underwent p-PCI were retrospectively analyzed. Acute ST was defined as thrombosis that occurred in the first (0-1) days following primary coronary stenting, and patients who had undergone p-PCI were divided into two groups: ST group and no-ST group. The cut-off value for Mg obtained by the receiver-operating characteristic curve analysis was less than 1.91 mg/dl for the prediction of acute ST (area under the curve was 0.761; 95% confidence interval, 0.706-0.816; P<0.001; sensitivity, 70%; specificity, 69%). Serum Mg levels were significantly lower in the ST group compared with the no-ST group (median 1.80 mg/dl, interquartile range 1.70-2.00 mg/l vs. median 2.10 mg/dl, interquartile range 1.90-2.20 mg/dl, P<0.001). After multivariable adjustment for clinical, laboratory, and angiographic variables, Mg remained a strong independent predictor for acute ST (odds ratio 5.802, 95% confidence interval, 3.069-10.967; P<0.001).
  
  
  CONCLUSIONS
  Serum Mg level is associated independently with the risk of acute ST in patients with STEMI who undergo p-PCI.
authors.affiliation: aDepartment of Cardiology, Ankara Numune Education and Research Hospital bDepartment of Cardiology, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Çiçek
authors.forename: Sadık Kadri
authors.initials: SK
authors.lastname: Açıkgoz
authors.forename: Çağrı
authors.initials: Ç
authors.lastname: Yayla
authors.forename: Harun
authors.initials: H
authors.lastname: Kundi
authors.forename: Mehmet
authors.initials: M
authors.lastname: İleri
mesh_terms: D000208:Acute Disease; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects*; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D008274:Magnesium