title: [Influence of gravity discharge on the content of isatin-binding proteins in mice: results of ground-based and space research under the program Bion-M №1].
abstract: Isatin-binding activity of mice liver proteins has been investigated in the samples from the control and flight groups by using the methods of biosensor and proteomic analysis. It was found the higher isatin-binding activity in mice of flight group. The content of a number of individual isatin-binding proteins in the samples of the flight groups differ slightly from the ground control. However, in samples from animals which have weekly post-flight adaptation, the level of certain proteins was significantly increased. The latter allows us to assume that the main events in the proteome of mice (at least in subproteome of isatin-binding proteins), occurs in early post-flight period.
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Ivanov
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Medvedev
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Buneeva
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Gnedenko
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Ershov
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: Y V
authors.initials: YV
authors.lastname: Mezencev
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: E O
authors.initials: EO
authors.lastname: Yablokov
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Kaluzhsky
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Florinskaya
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: N E
authors.initials: NE
authors.lastname: Moskaleva
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Zgoda
mesh_terms: D000199:Actins / Q000302:isolation & purification / Q000378:metabolism; D000222:Adaptation, Physiological; D000426:Alcohol Dehydrogenase / Q000302:isolation & purification / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000302:isolation & purification / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000302:isolation & purification / Q000378:metabolism; D007510:Isatin / Q000737:chemistry*; D008099:Liver / Q000737:chemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D054464:Peroxiredoxins / Q000302:isolation & purification / Q000378:metabolism; D011485:Protein Binding; D020543:Proteome / Q000302:isolation & purification / Q000378:metabolism; D013026:Space Flight; D013997:Time Factors; D014893:Weightlessness
chemical_list: D000199:Actins; D002352:Carrier Proteins; D020543:Proteome; D007510:Isatin; D000426:Alcohol Dehydrogenase; D054464:Peroxiredoxins; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D000444:Aldehyde Dehydrogenase
keywords: Bion (satellite); biosensors; gravitational unloading; isatin-binding proteins; mass spectrometry; mice; proteome