title: Alpha power oscillation in the frontal cortex under Bromazepam and Modafinil effects.
abstract: OBJECTIVE
  Our aim was to investigate and compare the neuromodulatory effects of bromazepam (6 mg) and modafinil (200 mg) during a sensorimotor task analyzing the changes produced in the absolute alpha power.
  
  
  METHODS
  The sample was composed of 15 healthy individuals exposed to three experimental conditions: placebo, modafinil and bromazepam. EEG data were recorded before, during and after the execution of the task. A three-way ANOVA was applied, in order to compare the absolute alpha power among the factors: Group (control, bromazepam and modafinil) Condition (Pre and Post-drug ingestion) and Moment (pre and post-stimulus).
  
  
  RESULTS
  Interaction was found between the group and condition factors for Fp1, F4 and F3. We observed a main effect of moment and condition for the Fp2, F8 and Fz electrodes.
  
  
  CONCLUSIONS
  We concluded that drugs may interfere in sensorimotor processes, such as in the performance of tasks carried out in an unpredictable scenario.
authors.affiliation: Instituto de Psiquiatria, Neurofisiologia e Neuropsicologia da Atenção, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Danielle
authors.initials: D
authors.lastname: Aprigio
authors.affiliation: Instituto de Psiquiatria, Neurofisiologia e Neuropsicologia da Atenção, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Washington
authors.initials: W
authors.lastname: Adolfo
authors.affiliation: Instituto de Psiquiatria, Neurofisiologia e Neuropsicologia da Atenção, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Bittencourt
authors.affiliation: Instituto de Psiquiatria, Mapeamento Cerebral e Integração Sensorial Motor, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Gongora
authors.affiliation: Mapeamento Cerebral e Laboratório de Plasticidade, Universidade Federal do Piauí, Parnaíba, PI, Brazil.
authors.forename: Silmar
authors.initials: S
authors.lastname: Teixeira
authors.affiliation: Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Basile
authors.affiliation: Medical School Hamburg, Faculty of Human Sciences, Hamburg, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Budde
authors.affiliation: Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Cagy
authors.affiliation: Instituto de Psiquiatria, Mapeamento Cerebral e Integração Sensorial Motor, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Ribeiro
authors.affiliation: Instituto de Psiquiatria, Neurofisiologia e Neuropsicologia da Atenção, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: Velasques
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D058256:Brain Waves / Q000187:drug effects; D001960:Bromazepam / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D004812:Epidemiologic Methods; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects* / Q000502:physiology; D018757:GABA Modulators / Q000494:pharmacology*; D006801:Humans; D008297:Male; D000077408:Modafinil; D011597:Psychomotor Performance / Q000187:drug effects*; D012016:Reference Values; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D055815:Young Adult
chemical_list: D001559:Benzhydryl Compounds; D018757:GABA Modulators; D000077408:Modafinil; D001960:Bromazepam