title: Prognostic Significance of Secreted Frizzled-Related Protein 2 Expression in Cytogenetically Normal Primary Acute Myeloid Leukemia.
abstract: BACKGROUND
  Deregulation of secreted frizzled-related protein 2 (sFRP2) has been found in many types of cancer. However, the pattern of sFRP2 expression in acute myeloid leukemia (AML) is still unclear.
  
  
  METHODS
  This study aimed to validate the prognostic significance of sFRP2 expression in 54 older patients with cytogenetic normal acute myeloid leukemia (CN-AML) using real-time quantitative polymerase chain reaction.
  
  
  RESULTS
  sFRP2 expression was decreased markedly in patients compared with controls (P < 0.001). No correlation was found between sFRP2 gene expression and WBCs, hemoglobin, platelets, FAB type, NMP1 and FLT3/ITD mutations at diagnosis. All patients were treated with standard induction chemotherapy. Patients with high sFRP2 expression had higher incidence of complete remission rate (P = 0.04) and better overall survival (P = 0.026). Multivariate analysis revealed that high sFRP2 expression was a prognostic factor for older patients with CN-AML.
  
  
  CONCLUSIONS
  This study demonstrated that sFRP2 gene expression at diagnosis had an impact on outcome of elderly CN-AML patients.
authors.affiliation: Clinical Pathology Department (RMA), Faculty of Medicine, Mansoura University, Mansoura, Egypt; Clinical Hematology unit (MMT), Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt; and General Medicine Department (EMA), Faculty of medicine for girls, Alazhar University, Cairo, Egypt.
authors.forename: Rabab M
authors.initials: RM
authors.lastname: Aly
authors.forename: Mona M
authors.initials: MM
authors.lastname: Taalab
authors.forename: Eman M
authors.initials: EM
authors.lastname: Abdsalam
mesh_terms: D000368:Aged; D004534:Egypt; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D060828:Induction Chemotherapy / Q000379:methods / Q000706:statistics & numerical data; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D007958:Leukocyte Count / Q000706:statistics & numerical data; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D012074:Remission Induction / Q000379:methods; D013223:Statistics as Topic; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D006454:Hemoglobins; D008565:Membrane Proteins; D051941:fms-Like Tyrosine Kinase 3; C109618:SFRP2 protein, human; D000094742:Secreted Frizzled-Related Proteins; C497970:FLT3 protein, human