title: Lipid metabolism in mycobacteria--Insights using mass spectrometry-based lipidomics.
abstract: Diseases including tuberculosis and leprosy are caused by species of the Mycobacterium genus and are a huge burden on global health, aggravated by the emergence of drug resistant strains. Mycobacteria have a high lipid content and complex lipid profile including several unique classes of lipid. Recent years have seen a growth in research focused on lipid structures, metabolism and biological functions driven by advances in mass spectrometry techniques and instrumentation, particularly the use of electrospray ionization. Here we review the contributions of lipidomics towards the advancement of our knowledge of lipid metabolism in mycobacterial species.
authors.affiliation: Swiss Tropical and Public Health Institute, CH-4051 Basel, Switzerland; University of Basel, CH-4000 Basel, Switzerland.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Crick
authors.affiliation: Swiss Tropical and Public Health Institute, CH-4051 Basel, Switzerland; University of Basel, CH-4000 Basel, Switzerland; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address: xueli.guan@ntu.edu.sg.
authors.forename: Xue Li
authors.initials: XL
authors.lastname: Guan
mesh_terms: D019295:Computational Biology; D006017:Glycolipids / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis; D013058:Mass Spectrometry; D009161:Mycobacterium / Q000378:metabolism*; D009171:Mycolic Acids / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D006017:Glycolipids; D008055:Lipids; D009171:Mycolic Acids; D014280:Triglycerides; C015518:sulfolipids
keywords: Lipidomics; Mass spectrometry; Metabolism; Mycobacterium; Systems biology; Tuberculosis