title: Polyelectrolyte Multilayers: A Versatile Tool for Preparing Antimicrobial Coatings.
abstract: The prevention of pathogen colonization of medical implants represents a major medical and financial issue. The development of antimicrobial coatings aimed at protecting against such infections has thus become a major field of scientific and technological research. Three main strategies are developed to design such coatings: (i) the prevention of microorganisms adhesion and the killing of microorganisms (ii) by contact and (iii) by the release of active compounds in the vicinity of the implant. Polyelectrolyte multilayer (PEM) technology alone covers the entire widespread spectrum of functionalization possibilities. PEMs are obtained through the alternating deposition of polyanions and polycations on a substrate, and the great advantages of PEMs are that (i) they can be applied to almost any type of substrate whatever its shape and composition; (ii) various chemical, physicochemical, and mechanical properties of the coatings can be obtained; and (iii) active compounds can be embedded and released in a controlled manner. In this article we will give an overview of the field of PEMs applied to the design of antimicrobial coatings, illustrating the large versatility of the PEM technology.
authors.affiliation: Centre National de la Recherche Scientifique, Institut Charles Sadron, UPR 22 , 23 rue du Loess, 67034 Strasbourg, France.|Institut National de la Santé et de la Recherche Médicale, Biomaterials and Bioengineering, UMR 1121 , 11 rue Humann, 67085 Strasbourg, France.|Université de Strasbourg , Faculté de Chirurgie Dentaire, 2 rue Sainte-Elisabeth, 67000 Strasbourg, France.
authors.forename: Lydie
authors.initials: L
authors.lastname: Séon
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Biomaterials and Bioengineering, UMR 1121 , 11 rue Humann, 67085 Strasbourg, France.|Université de Strasbourg , Faculté de Chirurgie Dentaire, 2 rue Sainte-Elisabeth, 67000 Strasbourg, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lavalle
authors.affiliation: Centre National de la Recherche Scientifique, Institut Charles Sadron, UPR 22 , 23 rue du Loess, 67034 Strasbourg, France.|Institut National de la Santé et de la Recherche Médicale, Biomaterials and Bioengineering, UMR 1121 , 11 rue Humann, 67085 Strasbourg, France.|Université de Strasbourg , Faculté de Chirurgie Dentaire, 2 rue Sainte-Elisabeth, 67000 Strasbourg, France.|Université de Strasbourg , Ecole Européenne de Chimie, Polymères et Matériaux, 25 rue Becquerel, 67087 Strasbourg, France.|International Center for Frontier Research in Chemistry, 8 allée Gaspard Monge, 67083 Strasbourg, France.|Institut Universitaire de France , 103 boulevard Saint-Michel, 75005 Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Schaaf
authors.affiliation: Centre National de la Recherche Scientifique, Institut Charles Sadron, UPR 22 , 23 rue du Loess, 67034 Strasbourg, France.|International Center for Frontier Research in Chemistry, 8 allée Gaspard Monge, 67083 Strasbourg, France.|University of Strasbourg Institute of Advanced Study , 5 allée du Général Rouvillois, 67083 Strasbourg, France.
authors.forename: Fouzia
authors.initials: F
authors.lastname: Boulmedais
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry; D000071228:Polyelectrolytes; D011108:Polymers / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D011073:Polyamines; D000071228:Polyelectrolytes; D011108:Polymers