title: Myeloid derived suppressor cells in inflammatory conditions of the central nervous system.
abstract: The knowledge of the immune system elements and their relationship with other tissues, organs and systems are key approximations for the resolution of many immune-related disorders. The control of the immune response and/or its modulation from the pro-inflammatory to the anti-inflammatory response is being deeply studied in the field. In the last years, the study of myeloid-derived suppressor cells (MDSCs), a group of immature myeloid cells with a high suppressive activity on T cells has been extensively addressed in cancer. In contrast, their role in neuroimmune diseases is far from being totally understood. In this review, we will summarize data about MDSCs coming from the study of neuroinflammatory diseases in general and their potential role in multiple sclerosis, in order to introduce the putative use of this extraordinary promising cell type for future cell-based therapies. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.
authors.affiliation: Grupo de Neurobiología del Desarrollo-GNDe, Hospital Nacional de Parapléjicos, Finca "La Peraleda" s/n, E-45071 Toledo, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Melero-Jerez
authors.affiliation: Grupo de Neurobiología del Desarrollo-GNDe, Hospital Nacional de Parapléjicos, Finca "La Peraleda" s/n, E-45071 Toledo, Spain; Centro de Biología Molecular Severo Ochoa. Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: María Cristina
authors.initials: MC
authors.lastname: Ortega
authors.affiliation: Animal Experimental Unit, Scientific Instrumentation Center (CIC), Campus de la Cartuja, Universidad de Granada, Granada, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Moliné-Velázquez
authors.affiliation: Grupo de Neurobiología del Desarrollo-GNDe, Hospital Nacional de Parapléjicos, Finca "La Peraleda" s/n, E-45071 Toledo, Spain. Electronic address: dclemente@sescam.jccm.es.
authors.forename: Diego
authors.initials: D
authors.lastname: Clemente
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology / Q000473:pathology* / Q000637:transplantation; D015213:Neuroimmunomodulation; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
keywords: Autoimmunity; Cell therapy; Multiple sclerosis; Neuroregeneration; Spinal cord injury; T cell suppression