title: Guided extracellular matrix formation from fibroblast cells cultured on bio-inspired configurable multiscale substrata.
abstract: Engineering complex extracellular matrix (ECM) is an important challenge for cell and tissue engineering applications as well as for understanding fundamental cell biology. We developed the methodology for fabrication of precisely controllable multiscale hierarchical structures using capillary force lithography in combination with original wrinkling technique for the generation of well-defined native ECM-like platforms by culturing fibroblast cells on the multiscale substrata [1]. This paper provides information on detailed characteristics of polyethylene glycol-diacrylate multiscale substrata. In addition, a possible model for guided extracellular matrix formation from fibroblast cells cultured on bio-inspired configurable multiscale substrata is proposed.
authors.affiliation: Interdisciplinary Program of Bioengineering, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Won-Gyu
authors.initials: WG
authors.lastname: Bae
authors.affiliation: Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju 500-757, Republic of Korea.
authors.forename: Jangho
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology, Ajou University School of Medicine, Suwon 443-721, Republic of Korea.
authors.forename: Yun-Hoon
authors.initials: YH
authors.lastname: Choung
authors.affiliation: Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul 440-746, Republic of Korea.
authors.forename: Yesol
authors.initials: Y
authors.lastname: Chung
authors.affiliation: Interdisciplinary Program of Bioengineering, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Kahp Y
authors.initials: KY
authors.lastname: Suh
authors.affiliation: School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 440-746, Republic of Korea.
authors.forename: Changhyun
authors.initials: C
authors.lastname: Pang
authors.affiliation: Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul 440-746, Republic of Korea.
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Republic of Korea.
authors.forename: Hoon Eui
authors.initials: HE
authors.lastname: Jeong