title: Long-term outcomes of colectomy surgery among patients with ulcerative colitis.
abstract: The objective of this study was to evaluate long-term health-related quality of life outcomes among patients who had a colectomy within the previous 10 years. A cross-sectional survey was administered to consecutive patients ≥18 years of age with ulcerative colitis who had a colectomy within the last 10 years from centers in Canada, Australia, and the United Kingdom. Data were extracted from medical chart reviews to confirm selected self-reported patient characteristics. Of 351 survey respondents, 49 % were male and the median age was 40 years (interquartile range 30-52). Respondents were diagnosed with UC a median of 9.2 (5.7-15.1) years prior to the survey and first surgery occurred a median of 3.7 (2.1-5.8) years ago. Although most respondents (84 %) reported improved quality of life compared to the status before surgery, 81 % experienced problems in at least one of the following areas: depression, work productivity, restrictions in diet, body image, and sexual function. According to HADS scores, 30 and 17 % of survey respondents experienced anxiety and depression, respectively. Among moderate to severe UC patients pre-colectomy, 27 % of men and 28 % of women reported that their sexual life was worse now than before surgery. The mean EQ-5D utility index score overall was 0.79 (95 % confidence interval 0.77-0.81). Quality of life after colectomy for UC is generally good, but there are persistent quality of life issues that impact multiple domains, including psychological and sexual functioning.
authors.affiliation: Division of General Surgery, Providence Health Care, St. Paul's Hospital, Room C310, St Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6 Canada.
authors.forename: Carl
authors.initials: C
authors.lastname: Brown
authors.affiliation: Department of Gastroenterology, The Alfred Hospital and Monash University, Melbourne, VIC 3004 Australia.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Gibson
authors.affiliation: IBD Unit, St. Mark's Hospital NWLH NHS Trust, Northwick Park, Harrow, London HA1 3UJ UK.
authors.forename: Ailsa
authors.initials: A
authors.lastname: Hart
authors.affiliation: Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB T2N 4N1 Canada.
authors.forename: Gilaad G
authors.initials: GG
authors.lastname: Kaplan
authors.affiliation: Merck & Co. Inc., Rahway, 07065 NJ USA.
authors.forename: Sumesh
authors.initials: S
authors.lastname: Kachroo
authors.affiliation: Merck & Co. Inc., Rahway, 07065 NJ USA ; Ferris University, Big Rapids, 49307 MI USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ding
authors.affiliation: Oxford Outcomes Inc., an ICON plc company, Bethesda, 20814 MD USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Hautamaki
authors.affiliation: Merck & Co. Inc., Rahway, 07065 NJ USA ; Sanofi US and Center for Clinical Epidemiology and Biostatistics, Bridgewater, 08807 NJ USA ; University of Pennsylvania School of Medicine, Philadelphia, 19104 NJ USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Fan
authors.affiliation: Merck & Co. Inc., Rahway, 07065 NJ USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Black
authors.affiliation: Merck & Co. Inc., Rahway, 07065 NJ USA.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Hu
authors.affiliation: Outcomes Research Strategies in Health, Washington, 20008 DC USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Beusterien
keywords: Colectomy; Quality of life, pouchitis/pouch failure; Survey; Ulcerative colitis