title: Is there any correlation between levels of serum ostepontin, CEA, and FDG uptake in lung cancer patients with bone metastasis?
abstract: OBJECTIVE
  In this study, an evaluation was made of the relationship between the serum levels of carcinoembryonic antigen (CEA), osteopontin (OPN), and the semi-quantitative parameters of 18-fluoro-2-deoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in lung cancer patients with bone metastasis.
  
  
  METHODS
  The evaluation included 42 non-small cell lung cancer (NSCLC) and 31 small cell lung cancer (SCLC) patients who were referred to our institution for staging by (18)F-FDG PET/CT. The biochemical parameters measured included CEA and OPN serum levels.
  
  
  RESULTS
  Serum levels of OPN in NSCLC patients with and without bone metastasis were 21.20±4.97 ng/ml and 13.33±4.53 ng/ml, respectively (p<0.05). In SCLC patients with and without bone metastasis serum OPN levels were 23.95±4.78 ng/ml and 17.30±3.09 ng/ml, respectively (p<0.05). Serum levels of CEA in NSCLC patients with and without bone metastasis were 33.79±6.49 ng/ml and 11.74±2.96 ng/ml, respectively (p<0.05). In SCLC patients with and without bone metastasis serum levels of CEA were 28.93±4.59 ng/ml and 13.88±4.47 ng/ml, respectively (p<0.05). There were no correlations between primary tumor SUVmax, and serum levels of CEA and OPN.
  
  
  CONCLUSIONS
  Bone metastasis can be detected in patients with lung cancer by measuring CEA and OPN levels. Increased levels of CEA and OPN levels may be considered an early warning sign in patients needing accurate imaging, as they are at higher risk of bone metastasis.
authors.affiliation: Department of Nuclear Medicine, Ataturk University Faculty of Medicine, Erzurum, Turkey. Electronic address: ayankursad@gmail.com.
authors.forename: A K
authors.initials: AK
authors.lastname: Ayan
authors.affiliation: Department of Radiation Oncology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Erdemci
authors.affiliation: Department of Nuclear Medicine, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Orsal
authors.affiliation: Department of Biochemistry, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Bayraktutan
authors.affiliation: Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Akpinar
authors.affiliation: Department of Pharmacology, Recep Tayyip Erdogan University Faculty of Medicine, Rize, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Topcu
authors.affiliation: Department of Internal Medicine, Ataturk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Turkeli
authors.affiliation: Department of Nuclear Medicine, Mevlana University Faculty of Medicine, Konya, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Seven
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D001859:Bone Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000556:secondary*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000000981:diagnostic imaging / Q000556:secondary; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D053495:Osteopontin / Q000097:blood*; D000072078:Positron Emission Tomography Computed Tomography; D055752:Small Cell Lung Carcinoma / Q000097:blood* / Q000000981:diagnostic imaging / Q000556:secondary
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D053495:Osteopontin
keywords: Bone metastasis; CEA; Cáncer de pulmón; Lung cancer; Metástasis ósea; OPN; Positron emission tomography; Tomografía de emisión de positrones