title: Good quality of life outcomes after treatment of prosthetic joint infection with debridement and prosthesis retention.
abstract: Patients treated for early prosthetic joint infection (PJI) with surgical debridement and prosthesis retention have a rate of successful infection eradication that is similar to patients treated with the traditional approach of prosthesis exchange. It is therefore important to consider other outcomes after prosthetic joint infection treatment that may influence management decisions, such as quality of life (QOL). Our aim was to describe infection cure rates and quality of life for patients with prosthetic joint infection treated with debridement and prosthesis retention and to determine if treatment with this approach was a risk factor for poor quality of life outcomes. Prospectively collected pre and post-arthroplasty data were available for 2,134 patients, of which PJI occurred in 41. For patients treated for prosthetic joint infection, the 2-year survival free of treatment failure was 87% (95%CI 84-89). Prosthetic joint infection cases treated with debridement and retention had a similar improvement from pre-arthroplasty to 12-months post-arthroplasty as patients without PJI in QOL according to the SF-12 survey. Prosthetic joint infection treated with debridement and retention was not a risk factor for poor quality of life on univariate or multivariate analysis. Prosthetic joint infection treated with debridement and prosthesis retention results in good cure rates and quality of life. Further studies are required that directly compare quality of life for different surgical approaches for prosthetic joint infection to better inform management decisions. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:898-902, 2016.
authors.affiliation: Department of Infectious Diseases, St Vincent's Hospital, 41 Victoria Pde Fitzroy, Victoria, 3065, Australia.|Northwest Academic Centre, Univeristy of Melbourne, 185 Cooper St Epping, Victoria, 3076, Australia.
authors.forename: Craig
authors.initials: C
authors.lastname: Aboltins
authors.affiliation: Department of Orthopaedic Surgery, St Vincent's Hospital, 41 Victoria Pde Fitzroy, Victoria, 3065, Australia.|The University of Melbourne Department of Surgery, St Vincent's Hospital, 41 Victoria Pde Fitzroy, Victoria, 3065, Australia.
authors.forename: Michelle
authors.initials: M
authors.lastname: Dowsey
authors.affiliation: Department of Orthopaedic Surgery, St Vincent's Hospital, 41 Victoria Pde Fitzroy, Victoria, 3065, Australia.|The University of Melbourne Department of Surgery, St Vincent's Hospital, 41 Victoria Pde Fitzroy, Victoria, 3065, Australia.
authors.forename: Trish
authors.initials: T
authors.lastname: Peel
authors.affiliation: Northwest Academic Centre, Univeristy of Melbourne, 185 Cooper St Epping, Victoria, 3076, Australia.|Department of Medicine, Northern Health, 185 Cooper St Epping, Victoria, 3076, Australia.
authors.forename: Wen K
authors.initials: WK
authors.lastname: Lim
authors.affiliation: Department of Orthopaedic Surgery, St Vincent's Hospital, 41 Victoria Pde Fitzroy, Victoria, 3065, Australia.|The University of Melbourne Department of Surgery, St Vincent's Hospital, 41 Victoria Pde Fitzroy, Victoria, 3065, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Choong
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003646:Debridement; D005260:Female; D006801:Humans; D008297:Male; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000601:surgery*; D011788:Quality of Life; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: arthroplasty; debridement; prosthetic related infections; quality of life