title: Effect of Afobazole and Betaine on DNA Damage in Placental and Embryonic Tissues of Rats with Experimental Streptozocin Diabetes.
abstract: DNA comet assay showed that the level of DNA damage in the placental and embryonic tissues of rats with streptozotocin-induced diabetes mellitus increased on gestation days 14 and 20. Afobazole and betaine administered per os effectively decreased the level of genotoxic damage; afobazole was most efficient in doses of 10 and 50 mg/kg and betaine in a dose of 100 mg/kg.
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. zabrodinavv@gmail.com.
authors.forename: V V
authors.initials: VV
authors.lastname: Zabrodina
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: E D
authors.initials: ED
authors.lastname: Shreder
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Shreder
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: A D
authors.initials: AD
authors.lastname: Durnev
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology*; D001622:Betaine / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016640:Diabetes, Gestational / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D004622:Embryo, Mammalian / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D009025:Morpholines / Q000494:pharmacology*; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D013311:Streptozocin
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D016587:Antimutagenic Agents; D001562:Benzimidazoles; D009025:Morpholines; D001622:Betaine; D013311:Streptozocin
keywords: DNA comet assay; Streptozotocin; afobazole; betaine; diabetes