title: Body mass index influence interferon-beta treatment response in multiple sclerosis.
abstract: Obesity is a possible risk factor of multiple sclerosis (MS), but the association between obesity and MS disease activity has not been explored. In a cohort of 86 MS patients, 80% of overweight or obese patients (BMI≥25kg/m(2)) had MRI activity compared to 48% of the normal-weight patients (BMI<25kg/m(2)) (p=0.001) during interferon-beta treatment. NEDA-status (no evidence of disease activity) was defined as a composite that consisted of absence of any relapses, sustained disability-progression and MRI-activity. Among normal-weight patients 26% obtained NEDA-status compared to only 13% of patients with BMI >25 (p=0.05). This may indicate that BMI affects interferon-beta treatment response.
authors.affiliation: Hormone Laboratory, Department of Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway. Electronic address: sgns@helse-bergen.no.
authors.forename: Silje Stokke
authors.initials: SS
authors.lastname: Kvistad
authors.affiliation: Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors.forename: Kjell-Morten
authors.initials: KM
authors.lastname: Myhr
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Trygve
authors.initials: T
authors.lastname: Holmøy
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Helse Sør-Øst Health Services Research Centre, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Jūratė
authors.initials: J
authors.lastname: Šaltytė Benth
authors.affiliation: Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Stig
authors.initials: S
authors.lastname: Wergeland
authors.affiliation: Multiple Sclerosis Centre Hakadal, Hakadal, Norway.
authors.forename: Antonie G
authors.initials: AG
authors.lastname: Beiske
authors.affiliation: Department of Medical Biochemistry, St. Olav's Hospital, Trondheim University Hospital, Norway; Clinic of Laboratory Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Kristian S
authors.initials: KS
authors.lastname: Bjerve
authors.affiliation: Department of Neurology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Harald
authors.initials: H
authors.lastname: Hovdal
authors.affiliation: Curato Oslo, Oslo, Norway.
authors.forename: Finn
authors.initials: F
authors.lastname: Lilleås
authors.affiliation: Department of Neurology, Molde Hospital, Norway; Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Rune
authors.initials: R
authors.lastname: Midgard
authors.affiliation: Unilabs Drammen, Drammen, Norway.
authors.forename: Tom
authors.initials: T
authors.lastname: Pedersen
authors.affiliation: Department of Neuroradiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Søren J
authors.initials: SJ
authors.lastname: Bakke
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Annika E
authors.initials: AE
authors.lastname: Michelsen
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; KG Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway.
authors.forename: Pål
authors.initials: P
authors.lastname: Aukrust
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neuroradiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway.
authors.forename: Thor
authors.initials: T
authors.lastname: Ueland
authors.affiliation: Hormone Laboratory, Department of Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
authors.forename: Jørn V
authors.initials: JV
authors.lastname: Sagen
authors.affiliation: Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors.forename: Øivind
authors.initials: Ø
authors.lastname: Torkildsen
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001921:Brain / Q000473:pathology; D018450:Disease Progression; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D016899:Interferon-beta / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology*; D009765:Obesity / Q000150:complications*; D055815:Young Adult
chemical_list: D007155:Immunologic Factors; D016899:Interferon-beta
keywords: Body mass index (BMI); Interferon-beta treatment; MRI disease activity; Multiple sclerosis; No evidence of disease activity; Treatment response