title: Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.
abstract: Invited for the cover of this issue are Paul V. Murphy and co-workers at the National University of Ireland Galway (NUI Galway) and Warsaw University. The image depicts MGSTA-6 giving a stop signal to tumour cells that are on the move. Read the full text of the article at 10.1002/chem.201502861.
authors.affiliation: School of Chemistry, National University of Ireland, Galway (Ireland).
authors.forename: Daniele
authors.initials: D
authors.lastname: Lo Re
authors.affiliation: School of Chemistry, National University of Ireland, Galway (Ireland).
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Science, Warsaw (Poland).
authors.forename: Joanna
authors.initials: J
authors.lastname: Mucha
authors.affiliation: School of Chemistry, National University of Ireland, Galway (Ireland).
authors.forename: Leigh F
authors.initials: LF
authors.lastname: Jones
authors.affiliation: Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway (Ireland).
authors.forename: Lorraine
authors.initials: L
authors.lastname: Leahy
authors.affiliation: Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway (Ireland).
authors.forename: Corrado
authors.initials: C
authors.lastname: Santocanale
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Science, Warsaw (Poland).
authors.forename: Magdalena
authors.initials: M
authors.lastname: Krol
authors.affiliation: School of Chemistry, National University of Ireland, Galway (Ireland). paul.v.murphy@nuigalway.ie.
authors.forename: Paul V
authors.initials: PV
authors.lastname: Murphy
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010881:Piperidones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D047028:Macrocyclic Compounds; D018942:Macrolides; D010881:Piperidones; C418199:migrastatin