title: Tropism distribution among antiretroviral-naive HIV-2-infected patients.
abstract: The aim of this study was to describe HIV-2 R5/X4-tropism distribution in antiretroviral-naive HIV-2-infected patients. Population sequencing of the gp105 region was performed on peripheral blood mononuclear cells issued from 151 antiretroviral-naive patients. Tropism was successfully determined in 46 of 151 samples (30%) with six of 46 (13%) X4-tropic viruses. X4-tropism was associated with lower CD4 cell count (337 vs. 551/mm; P = 0.032) but not with plasma viral load. Thus, X4-tropism prevalence in HIV-2 antiretroviral-naive patients is similar to that observed in HIV-1.
authors.affiliation: aINSERM, IAME, UMR 1137 bIAME, UMR 1137, Université Paris Diderot, Sorbonne Paris Cité cAP-HP, Laboratoire de Virologie, Hôpital Bichat, Paris dISPED, Centre INSERM U897, Epidemiologie-Biostatistique, Université Bordeaux eINSERM, ISPED, Centre INSERM U897, Epidemiologie-Biostatistique fAP-HP, Hôpital Bichat, Service de Maladies Infectieuses et Tropicales, Paris, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Visseaux
authors.forename: Charlotte
authors.initials: C
authors.lastname: Charpentier
authors.forename: Alexandra
authors.initials: A
authors.lastname: Ozanne
authors.forename: Alexis
authors.initials: A
authors.lastname: Nizard
authors.forename: Suzon
authors.initials: S
authors.lastname: Drumard
authors.forename: Catherine
authors.initials: C
authors.lastname: Fagard
authors.forename: David
authors.initials: D
authors.lastname: Glohi
authors.forename: Florence
authors.initials: F
authors.lastname: Damond
authors.forename: Françoise
authors.initials: F
authors.lastname: Brun-Vézinet
authors.forename: Sophie
authors.initials: S
authors.lastname: Matheron
authors.forename: Diane
authors.initials: D
authors.lastname: Descamps
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015498:HIV-2 / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D008297:Male; D008875:Middle Aged; D015728:Receptors, HIV / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D056189:Viral Tropism; D053586:Virus Internalization; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D015728:Receptors, HIV; D054299:env Gene Products, Human Immunodeficiency Virus; C069790:gp105 envelope protein, Human immunodeficiency virus 2