title: Oncosuppressive functions of tribbles pseudokinase 3.
abstract: Tribbles pseudokinase 3 (TRIB3) belongs to the tribbles family of pseudokinases. In this article, we summarize several observation obtained by our laboratories supporting that TRIB3 plays a crucial role in the anti-cancer activity of cannabinoids (a novel family of potential anti-cancer agents derived from marijuana) and that TRIB3 genetic inactivation enhances cancer generation and progression.
authors.affiliation: Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Salazar
authors.affiliation: Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Lorente
authors.affiliation: Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Orea-Soufi
authors.affiliation: Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Dávila
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Institut de Neurociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Barcelona 08193, Spain.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Erazo
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Institut de Neurociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Barcelona 08193, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Lizcano
authors.affiliation: CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), 48940 Bilbao, Spain.
authors.forename: Arkaitz
authors.initials: A
authors.lastname: Carracedo
authors.affiliation: Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, U.K.
authors.forename: Endre
authors.initials: E
authors.lastname: Kiss-Toth
authors.affiliation: Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain gvelasco@ucm.es.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Velasco
mesh_terms: D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D001343:Autophagy / Q000235:genetics / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D063388:Endocannabinoids / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D063388:Endocannabinoids; D012097:Repressor Proteins; C474831:TRIB3 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt
keywords: animal models of cancer; autophagy; cannabinoids; endoplasmic reticulum (ER) stress; tribbles pseudokinases