title: Kinase phosphorylation monitoring with i-motif DNA cross-linked SERS probes.
abstract: We propose an ultrasensitive SERS-based peptide biosensor platform to monitor phosphorylation catalyzed by kinase in a dynamic format. The developed SERS strategy has a short response time with potential to monitor phosphorylation in live cells.
authors.affiliation: Agricultural and Biological Engineering, Bindley Bioscience Center, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. josephi@purdue.edu.
authors.forename: Wen
authors.initials: W
authors.lastname: Ren
authors.forename: Nur P
authors.initials: NP
authors.lastname: Damayanti
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Wang
authors.forename: Joseph M K
authors.initials: JM
authors.lastname: Irudayaraj
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D045744:Cell Line, Tumor; D004277:DNA, Single-Stranded / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D010766:Phosphorylation; D016315:Proto-Oncogene Proteins c-abl / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D013059:Spectrum Analysis, Raman
chemical_list: D004277:DNA, Single-Stranded; D009838:Oligodeoxyribonucleotides; D011725:Pyridines; C042861:4-thiopyridine; D006046:Gold; D016315:Proto-Oncogene Proteins c-abl