title: Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia.
abstract: Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, significant advances have been made in the elucidation of the ALL-associated processes. Thus, we understand that histone acetylation is involved in the permanent changes of gene expression controlling ALL developmental outcomes. In this article, we will focus on histone acetylation associated with ALL, their implications as biomarkers for prognostic, and their preclinical and clinical applications.
authors.affiliation: Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037 People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Diagnostic Sciences & Biomedical Sciences, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033 USA ; Department of Pediatric, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 USA.
authors.forename: Jiang F
authors.initials: JF
authors.lastname: Zhong
authors.affiliation: Department of Diagnostic Sciences & Biomedical Sciences, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033 USA ; Department of Pediatric, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 USA.
authors.forename: Andres
authors.initials: A
authors.lastname: Stucky
authors.affiliation: Department of Diagnostic Sciences & Biomedical Sciences, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033 USA ; Department of Pediatric, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 USA.
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Chen
authors.affiliation: Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 USA.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Press
authors.affiliation: Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037 People's Republic of China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
keywords: Acute lymphoblastic leukemia; Biomarker; Clinical application; Histone acetylation; Histone acetyltransferase; Histone deacetylase