title: Identifying Connectome Module Patterns via New Balanced Multi-Graph Normalized Cut.
abstract: Computational tools for the analysis of complex biological networks are lacking in human connectome research. Especially, how to discover the brain network patterns shared by a group of subjects is a challenging computational neuroscience problem. Although some single graph clustering methods can be extended to solve the multi-graph cases, the discovered network patterns are often imbalanced, e.g. isolated points. To address these problems, we propose a novel indicator constrained and balanced multi-graph normalized cut method to identify the connectome module patterns from the connectivity brain networks of the targeted subject group. We evaluated our method by analyzing the weighted fiber connectivity networks.
authors.affiliation: Computer Science and Engineering, University of Texas at Arlington, TX, USA.
authors.forename: Hongchang
authors.initials: H
authors.lastname: Gao
authors.affiliation: Radiology and Imaging Sciences, Indiana University School of Medicine, IN, USA.
authors.forename: Chengtao
authors.initials: C
authors.lastname: Cai
authors.affiliation: Department of Electronic Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Yan
authors.forename: Lin
authors.initials: L
authors.lastname: Yan
authors.forename: Joaquin Goni
authors.initials: JG
authors.lastname: Cortes
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Feiping
authors.initials: F
authors.lastname: Nie
authors.forename: John
authors.initials: J
authors.lastname: West
authors.forename: Andrew
authors.initials: A
authors.lastname: Saykin
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: Heng
authors.initials: H
authors.lastname: Huang
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging*; D001927:Brain Diseases / Q000000981:diagnostic imaging*; D063132:Connectome / Q000379:methods*; D006801:Humans; D009415:Nerve Net / Q000000981:diagnostic imaging; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity