title: Is renal denervation an effective treatment for hypertension? Comparison of recent meta-analysis and a multinational registry.
abstract: We compared the impact of renal denervation (RDN) on blood pressures using results available from a recent comprehensive meta-analysis and an international registry. The meta-analysis summarized recent trials in which RDN was compared with control groups that were treated only with antihypertensive medication; the registry only included patients treated with RDN. Both publications presented pretreatment pressures and changes 6 months postbaseline. Significant reductions in office systolic pressure and 24 h ambulatory systolic pressure were observed in both groups of the meta-analysis and the registry. However, the magnitude of blood pressure reduction with RDN and medical treatment was comparable in both the meta-analysis and registry. RDN has not been shown to be superior to medical management of hypertension in this combined experience of nearly 2000 hypertensive patients.
authors.affiliation: Department of Medicine, Cardiovascular Institute, The Icahn School of Medicine, New York, New York, USA.
authors.forename: Lawrence R
authors.initials: LR
authors.lastname: Krakoff
authors.forename: Samantha
authors.initials: S
authors.lastname: Sartori
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D003714:Denervation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000601:surgery; D007668:Kidney / Q000294:innervation / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012042:Registries