title: Coronary and Basilar Artery Ectasia Are Associated: Results From an Autopsy Case-Control Study.
abstract: OBJECTIVE
  Intracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy series.
  
  
  METHODS
  Sixteen stroke patients with IADE were identified among 381 stroke patients and were matched with 16 stroke patients without IADE. The heart and coronary arteries from all patients were examined after a prespecified protocol.
  
  
  RESULTS
  Coronary artery ectasia was observed in 8 of the stroke patients with IADE, and in none of the stroke patients without IADE (P=0.008). The diameters of basilar and right coronary arteries were positively correlated (IADE patients, r=0.51; P=0.003 and coronary artery ectasia patients, P=0.006).
  
  
  CONCLUSIONS
  This autopsy study examining the association of coronary artery ectasia and IADE in stroke patients suggests a common pathogenesis.
authors.affiliation: From AP-HP Pitié Salpêtrière Hospital, Department of Neuropathology Raymond Escourolle, Pierre et Marie Curie University, Paris, France (F.P., J-J.H., D.S, C.D., P.A.); Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Le Chesnay, France (F.P.); INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France (F.P., P.A); Department of Neurology and Stroke Centre, AP-HP Bichat University Hospital, Paris-Diderot University and Medical School, Paris, France (J.L., P.A.); and Versailles Saint-Quentin en Yvelines University, Versailles, France (F.P.).
authors.forename: Fernando
authors.initials: F
authors.lastname: Pico
authors.affiliation: From AP-HP Pitié Salpêtrière Hospital, Department of Neuropathology Raymond Escourolle, Pierre et Marie Curie University, Paris, France (F.P., J-J.H., D.S, C.D., P.A.); Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Le Chesnay, France (F.P.); INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France (F.P., P.A); Department of Neurology and Stroke Centre, AP-HP Bichat University Hospital, Paris-Diderot University and Medical School, Paris, France (J.L., P.A.); and Versailles Saint-Quentin en Yvelines University, Versailles, France (F.P.).
authors.forename: Julien
authors.initials: J
authors.lastname: Labreuche
authors.affiliation: From AP-HP Pitié Salpêtrière Hospital, Department of Neuropathology Raymond Escourolle, Pierre et Marie Curie University, Paris, France (F.P., J-J.H., D.S, C.D., P.A.); Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Le Chesnay, France (F.P.); INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France (F.P., P.A); Department of Neurology and Stroke Centre, AP-HP Bichat University Hospital, Paris-Diderot University and Medical School, Paris, France (J.L., P.A.); and Versailles Saint-Quentin en Yvelines University, Versailles, France (F.P.).
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Hauw
authors.affiliation: From AP-HP Pitié Salpêtrière Hospital, Department of Neuropathology Raymond Escourolle, Pierre et Marie Curie University, Paris, France (F.P., J-J.H., D.S, C.D., P.A.); Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Le Chesnay, France (F.P.); INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France (F.P., P.A); Department of Neurology and Stroke Centre, AP-HP Bichat University Hospital, Paris-Diderot University and Medical School, Paris, France (J.L., P.A.); and Versailles Saint-Quentin en Yvelines University, Versailles, France (F.P.).
authors.forename: Danielle
authors.initials: D
authors.lastname: Seilhean
authors.affiliation: From AP-HP Pitié Salpêtrière Hospital, Department of Neuropathology Raymond Escourolle, Pierre et Marie Curie University, Paris, France (F.P., J-J.H., D.S, C.D., P.A.); Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Le Chesnay, France (F.P.); INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France (F.P., P.A); Department of Neurology and Stroke Centre, AP-HP Bichat University Hospital, Paris-Diderot University and Medical School, Paris, France (J.L., P.A.); and Versailles Saint-Quentin en Yvelines University, Versailles, France (F.P.).
authors.forename: Charles
authors.initials: C
authors.lastname: Duyckaerts
authors.affiliation: From AP-HP Pitié Salpêtrière Hospital, Department of Neuropathology Raymond Escourolle, Pierre et Marie Curie University, Paris, France (F.P., J-J.H., D.S, C.D., P.A.); Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, Le Chesnay, France (F.P.); INSERM LVTS (Laboratory for Vascular Translational Science)-1148, Paris, France (F.P., P.A); Department of Neurology and Stroke Centre, AP-HP Bichat University Hospital, Paris-Diderot University and Medical School, Paris, France (J.L., P.A.); and Versailles Saint-Quentin en Yvelines University, Versailles, France (F.P.). pierre.amarenco@bch.aphp.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Amarenco
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D001488:Basilar Artery / Q000473:pathology*; D016022:Case-Control Studies; D003331:Coronary Vessels / Q000473:pathology*; D016208:Databases, Factual; D004108:Dilatation, Pathologic / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000473:pathology*
keywords: autopsy; coronary vessels; myocardial infarction; stroke; vertebrobasilar dolichoectasia