title: Teriparatide in Fracture Non-Unions.
abstract: BACKGROUND
  The use of teriparatide in the management of fracture disorders is poorly documented. This study aims to show that teriparatide administration may improve the healing process in patients with nonunions after open fixation of traumatic fractures of the lower limb.
  
  
  METHODS
  Four patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.
  
  
  RESULTS
  Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.
  
  
  CONCLUSIONS
  The efficacy of teriparatide in delayed or non unions is still unclear. It may induce an angiogenetic response which counteracts the features responsible for development of non-union.
  
  
  METHODS
  Level IV, therapeutic case series.
authors.affiliation: Department of Orthopaedic and Trauma Surgery, Hospital "S. Maria di Loreto Nuovo", Naples, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Coppola
authors.affiliation: Department of Orthopaedics and Traumatology, Sant'Anna Hospital, Via Ravona, San Fermo della Battaglia (Como), Italy.
authors.forename: A
authors.initials: A
authors.lastname: Del Buono
authors.affiliation: Department of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, Salerno, Italy ; Centre for Sports and Exercise Medicine ; Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, England.
authors.forename: N
authors.initials: N
authors.lastname: Maffulli
keywords: Fractures; internal fixation; non-union; surgery; teriparatide