title: Stem cell transplantation therapy in Parkinson's disease.
abstract: Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are still several existing obstacles to translating into clinical application. Here we review the stem-cell based therapies for Parkinson's disease and discuss the potential advantages and drawbacks. We hope this review may provide suggestions for viable strategies to overcome the current technical and biological issues associated with the application of stem cells in Parkinson's disease.
authors.affiliation: Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.|Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 83301 Taiwan.
authors.forename: Mu-Hui
authors.initials: MH
authors.lastname: Fu
authors.affiliation: Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.
authors.forename: Chia-Ling
authors.initials: CL
authors.lastname: Li
authors.affiliation: Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.|Division of Breeding and Genetics, Livestock Research Institute, Council of Agriculture, Tainan, 71246 Taiwan.
authors.forename: Hsiu-Lien
authors.initials: HL
authors.lastname: Lin
authors.affiliation: Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.|Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.
authors.forename: Pei-Chun
authors.initials: PC
authors.lastname: Chen
authors.affiliation: Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Calkins
authors.affiliation: Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.
authors.forename: Yu-Fan
authors.initials: YF
authors.lastname: Chang
authors.affiliation: Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.
authors.forename: Pei-Hsun
authors.initials: PH
authors.lastname: Cheng
authors.affiliation: Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.|Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.
authors.forename: Shang-Hsun
authors.initials: SH
authors.lastname: Yang
keywords: Cell replacement therapy; Neurodegenerative disease; Parkinson’s disease; Stem cells