title: Expansion sphincter pharyngoplasty for the treatment of OSA: a systemic review and meta-analysis.
abstract: This study seeks to determine the success rates of the expansion sphincter pharyngoplasty and its variants on the treatment of obstructive sleep apnea (OSA). Systematic review and meta-analysis. Two independent searches of MEDLINE, Google Scholar, Cochrane Library and Evidence Based Medicine Reviews to identify publications relevant to OSA and expansion pharyngoplasty. All relevant studies published before 31 March 2015 were included. Five studies were included in the systematic review and meta-analysis. The numbers of patients in each paper ranged from 10 to 85 (total = 155), and mean age ranged from 8 to 56 years. Substantial and consistent improvement in PSG outcomes were observed post-expansion pharyngoplasty patients, with or without multilevel surgery groups. The results showed that the expansion pharyngoplasty technique has significantly lower AHI than control group [Standardised mean difference -7.32, 95 %CI (-11.11, -3.52), p = 0.0002]; however, substantial heterogeneity between these studies were observed. The mean pre-operative AHI (in the five papers) improved from 40.0 ± 12.6 to 8.3 ± 5.2 post-operatively. The overall pro-rated pooled success rate for all the patients was 86.3 %. The expansion pharyngoplasty is effective in the management of patients with OSA.
authors.affiliation: Otorhinolaryngology Head and Neck Surgery, Asia Sleep Centre, Paragon Medical Centre, Singapore, Singapore. drkpang@gmail.com.
authors.forename: Kenny P
authors.initials: KP
authors.lastname: Pang
authors.affiliation: Asia Sleep Centre, Singapore, Singapore.
authors.forename: Edward B
authors.initials: EB
authors.lastname: Pang
authors.affiliation: Biostatistics Unit, Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore.
authors.forename: Ma Thin Mar
authors.initials: MT
authors.lastname: Win
authors.affiliation: Asia Sleep Centre, Singapore, Singapore.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Pang
authors.affiliation: Sleep Surgery, Sleep Fellowship Program, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: B Tucker
authors.initials: BT
authors.lastname: Woodson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D006801:Humans; D008875:Middle Aged; D010614:Pharynx / Q000601:surgery*; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology / Q000601:surgery*; D055815:Young Adult
keywords: Expansion sphincter pharyngoplasty; Meta-analysis; Obstructive sleep apnea