title: Newborn screening for congenital hypothyroidism in Henan province, China.
abstract: BACKGROUND
  Congenital hypothyroidism is the most common congenital endocrine disorder. The study aimed to determine the congenital hypothyroidism incidence by newborn screening programs in Henan Province, China.
  
  
  METHODS
  The screening programs for congenital hypothyroidism are based on the measurement of TSH in dried blood spots. The TSH concentration was measured in the dry blood spot specimen using a DELFIA fluoroimmunoassay. The TSH cutoff concentration was 8mU/l.
  
  
  RESULTS
  The total coverage and the incidence of congenital hypothyroidism were 24.85% (5,142,148/20,694,441) and 0.37‰ (1992/5,142,148), respectively. The coverage and the incidence of CH were only 0.58% (4526/784,580) and 0.22‰ (1/4526) in 1997, respectively. However, the coverage and the incidence of CH were increased to 74.67% (1,203,278/1,611,582) and 0.32‰ (389/1,203,278). There were no significant differences in the number of congenital hypothyroidism between males and females (P>0.05). The number of congenital hypothyroidism was increased year after year.
  
  
  CONCLUSIONS
  The newborn screening program for CH is successful and quite effective.
authors.affiliation: Department of Henan Newborn Screening Center, the Third Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: De-Hua
authors.initials: DH
authors.lastname: Zhao
authors.affiliation: Department of Clinical Laboratory, Affiliated Tumor Hospital of Zhengzhou University, Henan Tumor Hospital, Zhengzhou, Henan, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Clinical Laboratory, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Jiao-Mei
authors.initials: JM
authors.lastname: Gong
authors.affiliation: Department of Henan Newborn Screening Center, the Third Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Meng
authors.affiliation: Department of Henan Newborn Screening Center, the Third Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: Department of Reproductive Medicine Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: zhangxiamy@126.com.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002681:China; D003409:Congenital Hypothyroidism / Q000097:blood* / Q000175:diagnosis*; D059788:Dried Blood Spot Testing; D005260:Female; D015200:Fluoroimmunoassay; D006801:Humans; D007231:Infant, Newborn; D008297:Male
keywords: Congenital hypothyroidism; Mental retardation; Newborn screening; Thyroid stimulating hormone