title: Effect of high-intensity exercise on interleukin-15 expression in rabbit synovia.
abstract: The objective of this study was to examine the effect of high-intensity exercise on interleukin-15 (IL-15) expression in rabbit synovia. We utilized 24 New Zealand white rabbits, which were randomly divided equally into high-intensity exercise and control groups. The former were forced to run for 60 min/day over 4 weeks at the speed of 30 m/min. The histological changes of cartilage and knee joint synovia were investigated with hematoxylin and eosin staining. Immunohistochemistry and enzyme-linked immunosorbent assays were performed to measure IL-15 expression. From these analyses, we identified knee articular cartilage damage and synovitis in the high-intensity exercise group. This group also exhibited higher IL-15 expression in their synovial fluid and tissues than was observed in the control group (P < 0.05). These results suggested that high-intensity exercise might lead to synovitis and articular cartilage damage, and that IL-15 overexpression in synovia might be associated with post-traumatic osteoarthritis.
authors.affiliation: Department of Anesthesiology, Binzhou People's Hospital, Binzhou, Shandong, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Binzhou People's Hospital, Binzhou, Shandong, China.
authors.forename: X D
authors.initials: XD
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Binzhou People's Hospital, Binzhou, Shandong, China.
authors.forename: W B
authors.initials: WB
authors.lastname: Zhu
authors.affiliation: Department of Anesthesiology, Binzhou People's Hospital, Binzhou, Shandong, China.
authors.forename: G F
authors.initials: GF
authors.lastname: Sun
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism; D019902:Chondrocytes / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D007150:Immunohistochemistry; D019409:Interleukin-15 / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D011817:Rabbits; D013582:Synovial Fluid / Q000378:metabolism*; D013583:Synovial Membrane / Q000378:metabolism
chemical_list: D019409:Interleukin-15