title: Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis.
abstract: The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a meta-analysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. We searched PubMed, Medline, and Korean Studies Information Service System databases and identified 29 case-control studies, containing data of 25,324 individuals, for this meta-analysis. The odds ratio (OR) and 95% confidence interval (95%CI) were used to determine the strength of the association. Overall, no significant association was detected in the allele model (G allele vs C allele, OR = 0.98, 95%CI = 0.93-1.03), dominant model (G/G+G/C vs C/C, OR = 1.00, 95%CI = 0.90-1.11), or recessive model (G/G vs G/C+C/C, OR = 0.96, 95%CI = 0.89-1.03). The meta-analysis results suggest that the VEGF -634 G/C polymorphism may not be related to the development of cancer. However, additional studies with larger sample size are required in order to provide supporting evidence.
authors.affiliation: Department of Dental Pharmacology, School of Dentistry, Cheonan, South Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Ban
authors.affiliation: Department of Medical Laser, Dankook University Graduate School, Cheonan, South Korea.
authors.forename: J I
authors.initials: JI
authors.lastname: Shin
authors.affiliation: Department of Medical Laser, Dankook University Graduate School, Cheonan, South Korea choh@dankook.ac.kr.
authors.forename: C-H
authors.initials: CH
authors.lastname: Oh
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D042442:Vascular Endothelial Growth Factors / Q000235:genetics*
chemical_list: D042442:Vascular Endothelial Growth Factors