title: Assessment of follicular and serum VEGF and IGF-1 in ICSI patients: hMG vs rFSH.
abstract: OBJECTIVE
  To investigate the effect of recombinant follicular stimulating hormone (r-FSH) and human menopausal gonadotropin (hMG) on follicular microenvironment via assessment of follicular and serum vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) levels in intracytoplasmic sperm injection (ICSI) cycles.
  
  
  METHODS
  Designed as a prospective cohort study. Twenty-five patients underwent controlled ovarian hyperstimulation (COH) with r-FSH and 20 patients underwent with hMG.
  
  
  RESULTS
  Both groups were comparable regarding the women's mean age and body mass index (BMI). The amount of VEGF (pg/ml) in serum and follicular fluid in the group I and II were comparable (275 ± 135.3 vs 330.7 ± 190.0; p > 0.05 and 2,081.1 ± 1095.1 vs 1,971.1 ± 975.6; p > 0.05, respectively). The amount of IGF-1 (ng/ml) in serum and follicular fluid in the group I and II were also comparable (225.3 ± 69.3 vs 204.1 ± 56.3, p > 0.05 and 176.1 ± 67.2 vs 185.8 ± 48.7, p > 0.05, respectively). Pregnancy rates were also comparable between groups.
  
  
  CONCLUSIONS
  The hMG and r-FSH in COH produced comparable follicular microenvironment regarding follicular VEGF and IGF-l.
authors.forename: M
authors.initials: M
authors.lastname: Bilge
authors.forename: S
authors.initials: S
authors.lastname: Ozdemirci
authors.forename: D
authors.initials: D
authors.lastname: Esinler
authors.forename: E
authors.initials: E
authors.lastname: Karahanoglu
authors.forename: I
authors.initials: I
authors.lastname: Esinler
authors.forename: T
authors.initials: T
authors.lastname: Aksu
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D015331:Cohort Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism*
chemical_list: D006063:Chorionic Gonadotropin; D042461:Vascular Endothelial Growth Factor A; D007334:Insulin-Like Growth Factor I; D005640:Follicle Stimulating Hormone