title: Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil.
abstract: Hematological abnormalities, such as anemia, leucopenia, and thrombocytopenia, secondary to peripheral destruction, are common in systemic lupus erythematosus (SLE). However, cytopenias from autoimmune myelofibrosis (AIMF) are extremely uncommon in SLE, with less than 40 reported cases in the literature. We report the case of a 33-year-old female who presented with bullous skin lesions and pancytopenia as the presenting manifestation of what was ultimately diagnosed as SLE with AIMF. She responded well to glucocorticoids and mycophenolate mofetil.
authors.affiliation: Division of Rheumatology, Mayo Clinic, Rochester, USA Ungprasert.patompong@mayo.edu.
authors.forename: P
authors.initials: P
authors.lastname: Ungprasert
authors.affiliation: Division of Rheumatology, Mayo Clinic, Rochester, USA.
authors.forename: V R
authors.initials: VR
authors.lastname: Chowdhary
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Davis
authors.affiliation: Division of Rheumatology, Mayo Clinic, Rochester, USA.
authors.forename: A
authors.initials: A
authors.lastname: Makol
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001706:Biopsy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D009173:Mycophenolic Acid / Q000627:therapeutic use; D010198:Pancytopenia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D011241:Prednisone / Q000627:therapeutic use*; D055728:Primary Myelofibrosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; D011241:Prednisone
keywords: Systemic lupus erythematosus; cutaneous lupus; hematologic changes