title: Analysis of Cystic Fibrosis in Federation of Bosnia and Herzegovina.
abstract: OBJECTIVE
  The aim of this study is to present the first total number of tested children in the Federation of Bosnia and Herzegovina and the number of children with positive sweat test. During the study we determined the number of ill children, the median age of children with cystic fibrosis, date of initial diagnosis, an average amount of chloride in the sweat.
  
  
  METHODS
  The study was a retrospective, conducted at the Department of Pulmonology Pediatric Clinic of University Clinical Center of Sarajevo.
  
  
  RESULTS
  In the period from March 2003 to December 2014, we have tested 625 children. 351 child were from Sarajevo Canton and 272 children from other cantons. Female children were more affected then male children, in the ratio of 1: 1,105. An average age of female children was 4.19±4.26 years, and the male 2.15±3.11 years. The median concentration of chloride in the sweat measured by sweat test was for male children 103.05±21.29 mmol/L, and for the female children 96.05±28.85 mmol/L.
  
  
  CONCLUSIONS
  Most of children in Federation of Bosnia and Herzegovina have ∆F508 gene mutation. In the post-war period we started to use a sweat test. Male children tend to live longer than female children with CF.
authors.affiliation: Pediatric Clinic of the University Clinical Centre of Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Amina
authors.initials: A
authors.lastname: Selimovic
authors.affiliation: Department for Cardioanesthesiology, Clinic for anesthesiology, reanimation and intensive care of the University Clinical Center of Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Ermina
authors.initials: E
authors.lastname: Mujicic
authors.affiliation: Sarajevo Medical School, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina.
authors.forename: Selma
authors.initials: S
authors.lastname: Milisic
authors.affiliation: Pediatric Clinic of the University Clinical Centre of Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Senka
authors.initials: S
authors.lastname: Mesihovic-Dinarevic
authors.affiliation: Pediatric Clinic of the University Clinical Centre of Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Amra
authors.initials: A
authors.lastname: Dzinovic
authors.affiliation: Pediatric Clinic of the University Clinical Centre of Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Selma
authors.initials: S
authors.lastname: Cengic
authors.affiliation: Pediatric Clinic of the University Clinical Centre of Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Ganimeta
authors.initials: G
authors.lastname: Bakalovic
authors.affiliation: Department of Orthopedic Surgery, General Hospital "Prim.dr.Abdulah Nakaš", Sarajevo, Bosnia and Herzegovina.
authors.forename: Mahir
authors.initials: M
authors.lastname: Moro
authors.affiliation: Department of Ophthalmology, General Hospital"Prim.dr.Abdulah Nakaš", Sarajevo, Bosnia and Herzegovina.
authors.forename: Meliha
authors.initials: M
authors.lastname: Djozic
authors.affiliation: Department of Biology, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Hezegovina.
authors.forename: Lada
authors.initials: L
authors.lastname: Lukic-Bilela
mesh_terms: D000293:Adolescent; D017522:Bosnia and Herzegovina / Q000453:epidemiology; D002594:Cetylpyridinium / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012737:Sex Factors; D013542:Sweat / Q000737:chemistry
chemical_list: D002594:Cetylpyridinium
keywords: chloride; cystic fibrosis; pilocarpine iontophoresis; sodium; sweat test