title: Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease.
abstract: BACKGROUND
  Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific Aβ pathology.
  
  
  METHODS
  Cognitive profiles; DMN connectivity alterations; and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, total tau, phosphorylated tau 181, and α-synuclein levels were studied in 21 patients with AD and 10 controls.
  
  
  RESULTS
  DMN activity is altered in AD. Posterior cingulate cortex (PCC) functional connectivity with other parts of DMN was related to cognitive function scores. The reduction of connectivity of the dorsal PCC with the retrosplenial cortex on the right side was closely related to decreased CSF Aβ1-42 levels in patients with AD.
  
  
  CONCLUSIONS
  The dorsal PCC and retrosplenial cortex may have special importance in the pathogenesis and cognitive findings of AD.
authors.affiliation: Hacettepe University, Institute of Health Sciences, Department of Neurological Sciences and Psychiatry, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Celebi
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
authors.forename: Andac
authors.initials: A
authors.lastname: Uzdogan
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Radiology, Ankara, Turkey.
authors.forename: Kader Karli
authors.initials: KK
authors.lastname: Oguz
authors.affiliation: Bilkent University, National Magnetic Resonance Research Center, Ankara, Turkey.
authors.forename: Arzu Ceylan
authors.initials: AC
authors.lastname: Has
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey.
authors.forename: Anil
authors.initials: A
authors.lastname: Dolgun
authors.affiliation: Hacettepe University, Institute of Health Sciences, Department of Neurological Sciences and Psychiatry, Ankara, Turkey.
authors.forename: Gul Yalcin
authors.initials: GY
authors.lastname: Cakmakli
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Akbiyik
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Elibol
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey. Electronic address: esensaka@hacettepe.edu.tr.
authors.forename: Esen
authors.initials: E
authors.lastname: Saka
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000503:physiopathology; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D010766:Phosphorylation; D051844:alpha-Synuclein / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; D051844:alpha-Synuclein; C075222:amyloid beta-protein (1-42); D016875:tau Proteins
keywords: Alzheimer’s disease; Biomarker; Cognition; Posterior cingulate cortex; Resting functional magnetic resonance imaging; Retrosplenial cortex