title: Functional remediation in bipolar disorder: 1-year follow-up of neurocognitive and functional outcome.
abstract: BACKGROUND
  Few randomised clinical trials have examined the efficacy of an intervention aimed at improving psychosocial functioning in bipolar disorder.
  
  
  OBJECTIVE
  To examine changes in psychosocial functioning in a group that has been enrolled in a functional remediation programme 1 year after baseline.
  
  
  METHODS
  This was a multicentre, randomised, rater-masked clinical trial comparing three patient groups: functional remediation, psychoeducation and treatment as usual over 1-year follow-up. The primary outcome was change in psychosocial functioning measured by means of the Functioning Assessment Short Test (FAST). Group×time effects for overall psychosocial functioning were examined using repeated-measures ANOVA (trial registration NCT01370668).
  
  
  RESULTS
  There was a significant group×time interaction for overall psychosocial functioning, favouring patients in the functional remediation group (F = 3.071, d.f. = 2, P = 0.049).
  
  
  CONCLUSIONS
  Improvement in psychosocial functioning is maintained after 1-year follow-up in patients with bipolar disorder receiving functional remediation.
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: C M
authors.initials: CM
authors.lastname: Bonnin
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Torrent
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Arango
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: B L
authors.initials: BL
authors.lastname: Amann
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Solé
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: González-Pinto
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Crespo
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Tabarés-Seisdedos
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Reinares
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Ayuso-Mateos
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: M P
authors.initials: MP
authors.lastname: García-Portilla
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: Á
authors.initials: Á
authors.lastname: Ibañez
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Salamero
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain evieta@clinic.ub.es.
authors.forename: E
authors.initials: E
authors.lastname: Vieta
authors.affiliation: Caterina del Mar Bonnin, PhD, Carla Torrent, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Celso Arango, MD, PhD, Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid; Benedikt L. Amann, MD, PhD, FIDMAG Hermanas Hospitalarias Research Foundation, CIBERSAM, Barcelona; Brisa Solé, PsyD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Ana González-Pinto, MD, PhD, Álava University Hospital, CIBERSAM, University of the Basque Country, Kronikgune, Vitoria; Jose Manuel Crespo, MD, PhD, Department of Psychiatry, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), CIBERSAM, Barcelona; Rafael Tabarés-Seisdedos, MD, PhD, Department of Medicine, University of Valencia, CIBERSAM, INCLIVA, Valencia; Maria Reinares, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia; Jose Luis Ayuso-Mateos, MD, PhD, Department of Psychiatry, Autonomous University of Madrid, Research Institute of the Hospital de la Princesa, CIBERSAM, Madrid; M. Paz García-Portilla, MD, PhD, Department of Psychiatry, University of Oviedo, CIBERSAM; Ángela Ibañez, MD, PhD, Department of Psychiatry, Ramon y Cajal University Hospital, University of Alcala, IRYCIS, CIBERSAM, Madrid; Manel Salamero, MD, PhD, Eduard Vieta, MD, PhD, Institute of Neurosciences, University of Barcelona, Hospital Clinic i Provincial, Catalonia; Anabel Martinez-Aran, PhD, Barcelona Bipolar Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Martinez-Aran
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy / Q000628:therapy*; D015928:Cognitive Behavioral Therapy; D056344:Executive Function; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D016037:Single-Blind Method; D013030:Spain; D016896:Treatment Outcome