title: Thoracoscopic Resection of Multiple Müllerian Cysts.
abstract: Müllerian cysts in the mediastinum were first described by Hattori in 2005 [1]. We report the first known case of multiple müllerian cysts in the thorax in a 35-year-old woman with cough and an abnormal chest roentgenogram. Multiple bilateral cysts were resected thoracoscopically. Histologic examination showed benign ciliated tubal epithelium that stained positive with immunohistochemical stains for estrogen receptor (ER), cancer antigen 125 (CA-125), Wilms' tumor protein 1 (WT-1), and paired box gene 8 (PAX8), confirming müllerian origin. We also review the embryogenesis and pathologic characteristics of müllerian cysts and the rare occurrence of their migration to the thorax.
authors.affiliation: Department of Surgery, The George Washington University Hospital, Washington, DC.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Skancke
authors.affiliation: Department of Pathology, The George Washington University Hospital, Washington, DC.
authors.forename: Tanya D
authors.initials: TD
authors.lastname: Auzenne
authors.affiliation: Department of Pathology, The George Washington University Hospital, Washington, DC.
authors.forename: Sana O
authors.initials: SO
authors.lastname: Tabbara
authors.affiliation: Department of Surgery, The George Washington University Hospital, Washington, DC. Electronic address: kmortman@mfa.gwu.edu.
authors.forename: Keith D
authors.initials: KD
authors.lastname: Mortman
mesh_terms: D000328:Adult; D018394:CA-125 Antigen / Q000378:metabolism; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008476:Mediastinal Cyst / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D009095:Mullerian Ducts / Q000473:pathology; D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D013906:Thoracoscopy; D025721:WT1 Proteins / Q000378:metabolism
chemical_list: D018394:CA-125 Antigen; D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D051761:Paired Box Transcription Factors; D011960:Receptors, Estrogen; D025721:WT1 Proteins; C583751:WT1 protein, human