title: Tissue-engineered bone treating simple bone cyst--a new strategy.
abstract: BACKGROUND
  The pathological fracture is a most important complication during bone cyst and can be prevented by early focus clearance and bone grafting. Tissue-engineered bone (TEB) with outstanding osteogenesis is a better choice for bone repair. Here, we firstly reported that TEB was used to heal bone cyst.
  
  
  METHODS
  The clinical data were collected from 23 patients who received bone defect repair separately with TEB or allogeneic bone (Allo-B) after erasion during 2004-2008. Allo-B had been as a control. The healing time and healing quality, the incidence of complications, the safety, and the bone grafting failure rate were compared.
  
  
  RESULTS
  In TEB group, the follow-up time was 28 ± 15.48 months; nine cases were confirmed healed (3.45 ± 2.01 months), one case was cyst healing with defect, and one case had relapse. In Allo-B, 12 patients were followed up for 28.58 ± 20.44 months; seven cases were confirmed healed (6.75 ± 3.31 mo), four cases were cyst healing with defect, and one case had relapse. After operation, no statistically significant differences in bone healing and incidence of complications were observed between two groups, but the difference in bone healing time was statistically significant (P < 0.05). There was no else tumorigenesis in both groups.
  
  
  CONCLUSIONS
  In treating simple bone cyst, Allo-B and TEB have considerable efficacy and safety; TEB is superior to Allo-B in respect of healing time; there is no rejection after TEB grafting but certain rejection after Allo-B grafting.
authors.affiliation: National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China; Center of Regenerative and Reconstructive Engineering Technology in Chongqing City, Chongqing, China; Tissue Engineering Laboratory of Chongqing City, Chongqing, China; Key Lab of Military Bone Tissue Engineering, Third Military Medical University, Chongqing, China. Electronic address: tianyonghou@126.com.
authors.forename: Tianyong
authors.initials: T
authors.lastname: Hou
authors.affiliation: National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China; Center of Regenerative and Reconstructive Engineering Technology in Chongqing City, Chongqing, China; Tissue Engineering Laboratory of Chongqing City, Chongqing, China; Key Lab of Military Bone Tissue Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Zhilin
authors.initials: Z
authors.lastname: Wu
authors.affiliation: National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China; Center of Regenerative and Reconstructive Engineering Technology in Chongqing City, Chongqing, China; Tissue Engineering Laboratory of Chongqing City, Chongqing, China; Key Lab of Military Bone Tissue Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Junchao
authors.initials: J
authors.lastname: Xing
authors.affiliation: National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China; Center of Regenerative and Reconstructive Engineering Technology in Chongqing City, Chongqing, China; Tissue Engineering Laboratory of Chongqing City, Chongqing, China; Key Lab of Military Bone Tissue Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Xuehui
authors.initials: X
authors.lastname: Wu
authors.affiliation: National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China; Center of Regenerative and Reconstructive Engineering Technology in Chongqing City, Chongqing, China; Tissue Engineering Laboratory of Chongqing City, Chongqing, China; Key Lab of Military Bone Tissue Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Luo
authors.affiliation: National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China; Center of Regenerative and Reconstructive Engineering Technology in Chongqing City, Chongqing, China; Tissue Engineering Laboratory of Chongqing City, Chongqing, China; Key Lab of Military Bone Tissue Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Xie
authors.affiliation: National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China; Center of Regenerative and Reconstructive Engineering Technology in Chongqing City, Chongqing, China; Tissue Engineering Laboratory of Chongqing City, Chongqing, China; Key Lab of Military Bone Tissue Engineering, Third Military Medical University, Chongqing, China.
authors.forename: Xuquan
authors.initials: X
authors.lastname: Wang
authors.affiliation: National & Regional United Engineering Lab of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China; Center of Regenerative and Reconstructive Engineering Technology in Chongqing City, Chongqing, China; Tissue Engineering Laboratory of Chongqing City, Chongqing, China; Key Lab of Military Bone Tissue Engineering, Third Military Medical University, Chongqing, China. Electronic address: jianzhong_xu@126.com.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D001845:Bone Cysts / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D002111:Calcaneus / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005269:Femur / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D006811:Humerus / Q000601:surgery*; D008297:Male; D011884:Radius / Q000601:surgery*; D023822:Tissue Engineering; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
keywords: Allogeneic bone; Bone cyst; Clinical application; Tissue-engineered bone