title: Clinical and pathogenetic features of early- and late-onset pre-eclampsia.
abstract: BACKGROUND
  PE is present in ∼2-8% of all pregnant women worldwide. Placental bed disorders at early and late PE have been not carried out yet. However, these studies help to explore details of the pathogenesis of PE, and to optimize the prognosis and obstetric management.
  
  
  OBJECTIVE
  To identify clinical and morphological differences between early- and late-onset PE based on a comprehensive observation of pregnant women with regard to morphological and immunohistochemical characteristics of the placental bed.
  
  
  METHODS
  One hundred fifty patients aged 18-43 years old delivered by cesarean section due to severe PE. The samples of placental bed tissue were studied by morphological and immunohistochemical methods.
  
  
  RESULTS
  The violation of invasion trophoblast, remodeling of spiral arteries were expressed in early onset PE; the degree of compensation of chronic hypoxia tissue in the area of the placental site was typical for late PE and was absent of an early onset PE.
  
  
  CONCLUSIONS
  Our studies confirm the need for separation of early- and late-onset PE, being justified in terms of different pathogenetic mechanisms of formation, and therefore the possibility of therapeutic effects, duration of pregnancy prolongation, forecasting, search early diagnostic markers of the disease, and personalized approaches.
authors.affiliation: a Department of Maternal-Fetal Medicine.
authors.forename: Zulfiya S
authors.initials: ZS
authors.lastname: Khodzhaeva
authors.affiliation: b Department of First Pathology , and.
authors.forename: Yevgeniya A
authors.initials: YA
authors.lastname: Kogan
authors.affiliation: c Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology" of the Ministry of Healthcare of the Russian Federation , Moscow , Russia.
authors.forename: Roman G
authors.initials: RG
authors.lastname: Shmakov
authors.affiliation: a Department of Maternal-Fetal Medicine.
authors.forename: Nataliya I
authors.initials: NI
authors.lastname: Klimenchenko
authors.affiliation: c Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology" of the Ministry of Healthcare of the Russian Federation , Moscow , Russia.
authors.forename: Albina S
authors.initials: AS
authors.lastname: Akatyeva
authors.affiliation: c Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology" of the Ministry of Healthcare of the Russian Federation , Moscow , Russia.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Vavina
authors.affiliation: a Department of Maternal-Fetal Medicine.
authors.forename: Alexey M
authors.initials: AM
authors.lastname: Kholin
authors.affiliation: c Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology" of the Ministry of Healthcare of the Russian Federation , Moscow , Russia.
authors.forename: Kamilla T
authors.initials: KT
authors.lastname: Muminova
authors.affiliation: c Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology" of the Ministry of Healthcare of the Russian Federation , Moscow , Russia.
authors.forename: Gennady T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D002585:Cesarean Section; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011225:Pre-Eclampsia / Q000145:classification* / Q000209:etiology* / Q000401:mortality; D011247:Pregnancy; D014327:Trophoblasts / Q000473:pathology*; D055815:Young Adult
keywords: Early onset of pre-eclampsia; late onset of pre-eclampsia; placental bed