title: [Frontier in bone biology].
abstract: Bone is an active organ in which bone mass is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption, i.e., coupling of bone formation and bone resorption. Recent advances in molecular bone biology uncovered the molecular mechanism of the coupling. A fundamental role of osteocyte in the maintenance of bone mass and whole body metabolism has also been revealed recently. Moreover, neurons and neuropeptides have been shown to be intimately involved in bone homeostasis though inter-organ network, in addition to "traditional" regulators of bone metabolism such as soluble factors and cytokines
authors.forename: Shu
authors.initials: S
authors.lastname: Takeda
mesh_terms: D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D002454:Cell Differentiation; D006801:Humans; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D015675:Osteocalcin / Q000378:metabolism; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism
chemical_list: D053245:RANK Ligand; D015675:Osteocalcin