title: Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure.
abstract: The effects of polypeptide complex from the kidney and short peptides AED, EDL, and AEDG on renal functions were studied in rats with cisplatin-induced acute renal failure. AED peptide decreased protein excretion and electrolyte concentration in the urine. Polypeptide complex from the kidney and peptides EDL and AEDG normalized diuresis, creatinine concentration in the urine and its excretion, glomerular filtration rate, and absolute resorption of sodium ions and reduced protein concentration in the urine and its excretion, the concentrations of sodium and potassium ions in the urine, and other parameters. EDL peptide produced was potent nephroprotective effect. It is known that the polypeptide complex of the kidney and short peptides restore the expression of signal molecules (marker of functional state of the kidneys), so these peptide substances can have nephroprotective effect during various renal pathologies.
authors.affiliation: Bukovinian State Medical University, Chernovtsy, Ukraine.
authors.forename: I I
authors.initials: II
authors.lastname: Zamorskii
authors.affiliation: Bukovinian State Medical University, Chernovtsy, Ukraine. tshchudrova@gmail.com.
authors.forename: T S
authors.initials: TS
authors.lastname: Shchudrova
authors.affiliation: St. Petersburg State Polytechnic University, St. Petersburg, Russia. linkova@gerontology.ru.|St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. linkova@gerontology.ru.
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: T E
authors.initials: TE
authors.lastname: Nichik
authors.affiliation: I. I. Mechnikov North-Western State Medical University, St. Petersburg, Russia.|St. Petersburg State Polytechnic University, St. Petersburg, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control* / Q000652:urine; D000818:Animals; D021461:Animals, Outbred Strains; D002945:Cisplatin / Q000009:adverse effects*; D003404:Creatinine / Q000652:urine; D019610:Cytoprotection / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D010455:Peptides / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine
chemical_list: D010455:Peptides; D012964:Sodium; D003404:Creatinine; D002945:Cisplatin; D011188:Potassium
keywords: acute renal failure; cisplatin; peptides