title: [Role of CyclinD1/IgH Detection by FISH in Differential Diagnostic Significance between Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia].
abstract: OBJECTIVE
  To investigate the feasibility of CyclinD1/IgH detection by FISH in diferential diagnosis between mantle cell lymphoma (MCL) and chronic lymphocytic leukeamia (CLL).
  
  
  METHODS
  The FISH detection was performed for CyclinD1/IgH fusion gene. A comprehensive analysis was carried out for clinical features, such as age, sex , WBC count and lymphocyte count, the bone marrow morphology and immunohistochemical staining were carried for CyclinD1/IgH.
  
  
  RESULTS
  It is often difficult to distinguish MCL from CLL by bone marrow morphology, when the cell morphology was not typical; there was no difference in age, sex, WBC count and lymphocyte count between MCL and CLL groups; 9 out of 52 patients were diagnosed as MCL, and the direction of CyclinD1/IgH by FISH was positive in 7 of 9 MCL, while 3 of the 7 patients were negative by immunohistochemical staining for CyclinD1.
  
  
  CONCLUSIONS
  Detection of CyclinD1/IgH by FISH can be used as a specific and feasible method for differential diagnosis of mantle cell lymphoma from chronic lymphocytic leukeamia.
authors.affiliation: Department of Pathology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China. E-mail: liguoping_827@126.com.
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Li
authors.affiliation: Fujian Instiute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China.
authors.forename: Wan-Zi
authors.initials: WZ
authors.lastname: Chen
authors.affiliation: Fujian Instiute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China. E-mail: huanghuif@126.com.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Huang
authors.affiliation: Fujian Instiute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China.
authors.forename: Jia-Di
authors.initials: JD
authors.lastname: Chen
authors.affiliation: Fujian Instiute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China.
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Lin
authors.affiliation: Fujian Instiute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000378:metabolism; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis* / Q000378:metabolism; D015514:Oncogene Proteins, Fusion / Q000378:metabolism*
chemical_list: C529133:IGH-CCND1 fusion protein, human; D015514:Oncogene Proteins, Fusion