title: Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size.
abstract: Perfluoro undecanoyl chain conjugated peptide nucleic acids (PNAs) show 2.5 to 3 fold higher cellular uptake efficiency in NIH 3T3 and HeLa cells compared to simple undecanoyl PNAs. Fluorination of PNAs leads to the formation of lower size (∼100-250 nm) nanoparticles compared to larger size (∼500 nm) nanoparticles from non-fluorinated PNAs, thereby improving the efficiency of cell penetration.
authors.affiliation: Chemical Biology Unit, Indian Institute of Science Education and Research (IISER), Dr Homi Bhabha Road, Pune 411008, Maharashtra, India.
authors.forename: Satheesh
authors.initials: S
authors.lastname: Ellipilli
authors.forename: Raghavendra
authors.initials: R
authors.lastname: vasudeva Murthy
authors.forename: Krishna N
authors.initials: KN
authors.lastname: Ganesh
mesh_terms: D000818:Animals; D005466:Fluorocarbons / Q000737:chemistry*; D051379:Mice; D018613:Microscopy, Confocal; D041681:NIH 3T3 Cells / Q000187:drug effects; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000493:pharmacokinetics; D010539:Permeability; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D005466:Fluorocarbons; D020135:Peptide Nucleic Acids; C003073:perfluoromethylcyclohexane