title: Aberrant function of frontoamygdala circuits in adolescents with previous verbal abuse experiences.
abstract: Previous studies reported an association of depressive disorder and structural alteration of frontolimbic brain regions in subjects with emotional abuse experiences during childhood and adolescence. The results suggest that aberrant function of the frontolimbic circuit and its relation with psychiatric symptoms can be found in adolescents with preclinical status. We investigated functional changes of frontolimbic networks during implicit negative emotional face processing and their relationships with depressive symptoms in adolescents with previous verbal abuse experiences. We designed a gender discrimination task using emotional faces to induce an implicit level of emotional exposure, and was completed by 31 preclinical male adolescents during an fMRI scan. The right amygdala activity and its functional connectivity with the rostral anterior cingulate cortex (ACC) during implicit processing of negative emotional faces showed a significant relationship with previous verbal abuse experiences. The hierarchical regression analyses showed that their current depressive symptoms were associated with aberrant functional interaction between the right amygdala activity and right amygdala-rostral ACC connectivity. Our findings of verbal abuse-related functional changes in the right frontoamygdala circuit may be related to vulnerability to future mood disorder.
authors.affiliation: Laboratory of Clinical Neuroscience and Development, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Laboratory of Clinical Neuroscience and Development, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Yoo
authors.affiliation: Laboratory of Clinical Neuroscience and Development, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.
authors.forename: Ko Woon
authors.initials: KW
authors.lastname: Kim
authors.affiliation: Department of Psychology, Kangwon National University, Chuncheon, Republic of Korea.
authors.forename: Jong-Sun
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Electrical Engineering, KAIST, Daejeon, Republic of Korea.
authors.forename: Dongchan
authors.initials: D
authors.lastname: Kim
authors.affiliation: Department of Electrical Engineering, KAIST, Daejeon, Republic of Korea.
authors.forename: HyunWook
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Psychiatry, Daejeon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Daejeon, Republic of Korea.
authors.forename: Jeewook
authors.initials: J
authors.lastname: Choi
authors.affiliation: Laboratory of Clinical Neuroscience and Development, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea; Center of Optics for Health Science, KAIST Institute, KAIST, Daejeon, Republic of Korea. Electronic address: bs.jeong@kaist.ac.kr.
authors.forename: Bumseok
authors.initials: B
authors.lastname: Jeong
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000098:blood supply / Q000503:physiopathology*; D000704:Analysis of Variance; D001931:Brain Mapping; D003863:Depression / Q000473:pathology* / Q000523:psychology; D017579:Domestic Violence / Q000523:psychology*; D004644:Emotions / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000098:blood supply / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D011795:Surveys and Questionnaires
chemical_list: D010100:Oxygen
keywords: Amygdala; Depression; Functional magnetic resonance imaging; Rostral anterior cingulate cortex; Verbal abuse