title: The correlation of plasma omentin-1 with insulin resistance in non-obese polycystic ovary syndrome.
abstract: OBJECTIVE
  Aberrant circulating adipokines are considered to be related to the pathological mechanism of polycystic ovary syndrome (PCOS). This study aims to evaluate the relationship between plasma omentin-1 levels, metabolic and hormonal parameters in the setting of non-obese Chinese women with PCOS.
  
  
  METHODS
  This was a case-controlled, cross-sectional study of 153 non-obese (BMI<25kg/m(2)) PCOS and 114 age-matched healthy non-obese control individuals. Levels of plasma omentin-1, fasting blood glucose, insulin and sexual hormones and ovary volume were analyzed in all subjects.
  
  
  RESULTS
  Plasma omentin-1 levels of non-obese PCOS individuals were significantly lower than in healthy non-obese controls. Body Mass Index (BMI), homeostasis model of assessment for insulin resistance index (HOMA-IR), levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), LH/FSH ratio and ovary volume (OV) were significantly higher in subjects with PCOS than controls. In the HOMA-IR stratified subgroups, PCOS individuals with insulin resistance had lower omentin-1 than those without insulin resistance after BMI adjustment. Omentin-1 was negatively correlated with BMI, HOMA-IR and fasting insulin. Multiple linear regressions revealed that BMI contributed to omentin-1 levels. Ovary volume was negatively correlated to HOMA-IR but had no correlation with omentin-1.
  
  
  CONCLUSIONS
  Plasma omentin-1 concentrations were decreased in the non-obese PCOS group. Insulin resistance could further decrease plasma omentin-1 in non-obese individuals with PCOS independent of BMI status.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Yang
authors.affiliation: Department of Ultrasonic Diagnosis, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
authors.forename: Xin-Hong
authors.initials: XH
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
authors.forename: Xing-Huan
authors.initials: XH
authors.lastname: Liang
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Suo
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
authors.forename: Zhen-Xing
authors.initials: ZX
authors.lastname: Huang
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
authors.forename: De-Cheng
authors.initials: DC
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
authors.forename: Ying-Fen
authors.initials: YF
authors.lastname: Qin
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China. Electronic address: zluo888@163.com.
authors.forename: Zuo-Jie
authors.initials: ZJ
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D002681:China; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005215:Fasting; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D037102:Lectins / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D009765:Obesity; D010053:Ovary / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000473:pathology / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D007328:Insulin; D037102:Lectins; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: BMI; IMC; Omentin-1; Omentine-1; PCOS; SOPK