title: Organocatalytic Aerobic Oxidation of Benzylic sp(3) C-H Bonds of Ethers and Alkylarenes Promoted by a Recyclable TEMPO Catalyst.
abstract: An entirely metal-free catalyst system consisting of an easily prepared recyclable new TEMPO derived sulfonic salt catalyst, and mineral acids (NaNO2 and HCl) has been developed for selective aerobic oxidation of structurally diverse benzylic sp(3) C-H bonds of ethers and alkylarenes. The mild reaction conditions allow for the generation of synthetically and biologically valued isochromanones and xanthones from readily accessible alkyl aromatic precursors in good yields.
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology , 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology , 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology , 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology , 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology , 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Hexin
authors.initials: H
authors.lastname: Xie
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology , 130 Mei-long Road, Shanghai 200237, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology , 130 Mei-long Road, Shanghai 200237, China.|Department of Chemistry and Chemical Biology, University of New Mexico , Albuquerque, New Mexico 87131-0001, United States.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang