title: Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant Enterococcus faecalis.
abstract: BACKGROUND
  Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome.
  
  
  METHODS
  Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin.
  
  
  RESULTS
  A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro .
  
  
  CONCLUSIONS
  Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.
authors.affiliation: Departamento Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Tiane Martin de
authors.initials: TM
authors.lastname: Moura
authors.affiliation: Departamento de Microbiologia, Parasitologia e Imunologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Fabrício Souza
authors.initials: FS
authors.lastname: Campos
authors.affiliation: Departamento Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Caierão
authors.affiliation: Departamento de Microbiologia, Parasitologia e Imunologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Ana Claudia
authors.initials: AC
authors.lastname: Franco
authors.affiliation: Departamento de Microbiologia, Parasitologia e Imunologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Paulo Michel
authors.initials: PM
authors.lastname: Roehe
authors.affiliation: Departamento Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Pedro Alves
authors.initials: PA
authors.lastname: d'Azevedo
authors.affiliation: Instituto de Ciência e Tecnologia de Alimentos, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Jeverson
authors.initials: J
authors.lastname: Frazzon
authors.affiliation: Departamento de Microbiologia, Parasitologia e Imunologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Ana Paula Guedes
authors.initials: AP
authors.lastname: Frazzon
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D059467:Transcriptome / Q000187:drug effects*; D014552:Urinary Tract Infections / Q000382:microbiology*; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance / Q000235:genetics*; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors; D014640:Vancomycin