title: Effect of omega-3 on hepatic regeneration in adult living donors undergoing hepatic resections for liver transplantation: A randomized controlled trial.
abstract: BACKGROUND
  Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been shown to improve liver regeneration in experimental models. Aim was to evaluate the effects of ω-3 PUFAs on hepatic regeneration in adult living donors undergoing partial hepatectomy for liver transplantation (LDLT).
  
  
  METHODS
  Forty LDLT donors were categorized into 2 groups: received either intravenous ω-3 PUFA-enriched lipid emulsion 20% infusion 7 mL/kg once a day for 2 days before surgery and postoperative day (POD) 0 (S group) or glucose 5% (C group). Hepatic regeneration was assessed by volume of the liver after 1 month using computed tomography, and serial serum levels of hepatocyte growth factor were measured at POD 1, 3, and 5.
  
  
  RESULTS
  Liver volume after 1 month was significantly larger in the S group than the C group (1286.75 ± 122.781 cm(3) vs 1169.15 ± 128.3, respectively; P = .00). Both the regeneration index and the regeneration percentage were significantly higher in the S group than the C group (P = .02 and P = .00, respectively). Serum levels of hepatocyte growth factor were significantly higher in the S group on POD 1, 3, and 5 than the C group ([in pg/mL] 188.10 ± 74.25 vs 123.30 ± 13.56, P = .00; 127.55 ± 32.40 vs 109.25 ± 8.89, P = .02; and 109.45 ± 21.44 vs 96.70 ± 5.57, P = .01; respectively).
  
  
  CONCLUSIONS
  Omega-3 polyunsaturated fatty acids effectively promoted liver regeneration and functional recovery following portal hypertension in the setting of LDLT.
authors.affiliation: National Liver Institute Menoufia University, Egypt. Electronic address: emansayed825@gmail.com.
authors.forename: Eman Sayed
authors.initials: ES
authors.lastname: Ibrahim
authors.affiliation: National Liver Institute Menoufia University, Egypt.
authors.forename: Sherif Mohamed
authors.initials: SM
authors.lastname: Saleh
authors.affiliation: National Liver Institute Menoufia University, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Hoseeny
authors.affiliation: National Liver Institute Menoufia University, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: El shaarawy
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005260:Female; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D008115:Liver Regeneration / Q000187:drug effects*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D011184:Postoperative Period
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; C066855:HGF protein, human; D017228:Hepatocyte Growth Factor
keywords: ALDLT; Fatty acids; Hepatic regeneration