title: Quercetin protection against ciprofloxacin induced liver damage in rats.
abstract: Ciprofloxacin is a common, broad spectrum antibacterial agent; however, evidence is accumulating that ciprofloxacin may cause liver damage. Quercetin is a free radical scavenger and antioxidant. We investigated histological changes in hepatic tissue of rats caused by ciprofloxacin and the effects of quercetin on these changes using histochemical and biochemical methods. We divided 28 adult female Wistar albino rats into four equal groups: control, quercetin treated, ciprofloxacin treated, and ciprofloxacin + quercetin treated. At the end of the experiment, liver samples were processed for light microscopic examination and biochemical measurements. Sections were prepared and stained with hematoxylin and eosin, and a histopathologic damage score was calculated. The sections from the control group appeared normal. Hemorrhage, inflammatory cell infiltration and intracellular vacuolization were observed in the ciprofloxacin group. The histopathological findings were reduced in the group treated with quercetin. Significant differences were found between the control and ciprofloxacin groups, and between the ciprofloxacin and ciprofloxacin + quercetin groups. Quercetin administration reduced liver injury caused by ciprofloxacin in rats. We suggest that quercetin may be useful for preventing ciprofloxacin induced liver damage.
authors.affiliation: a Department of Histology and Embryology , Faculty of Medicine, Bezmialem Vakif University , Istanbul , Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Taslidere
authors.affiliation: b Department of Anatomy , Faculty of Medicine, Adiyaman University , Adiyaman , Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Dogan
authors.affiliation: c Department of Histology and Embryology , Faculty of Medicine, Mugla Sıtkı Kocman University , Mugla , Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Elbe
authors.affiliation: d Department of Histology and Embryology , Faculty of Medicine, Inonu University , Malatya , Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Vardi
authors.affiliation: e Department of Anatomy , Faculty of Medicine, Inonu University , Malatya , Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Cetin
authors.affiliation: f Department of Biochemistry , Faculty of Medicine, Inonu University , Malatya , Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Turkoz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D002939:Ciprofloxacin / Q000494:pharmacology*; D019610:Cytoprotection; D004195:Disease Models, Animal; D005260:Female; D018384:Oxidative Stress / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology*; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D002939:Ciprofloxacin; D011794:Quercetin
keywords: ciprofloxacin; liver; quercetin; rat