title: Prospective evaluation of a simplified narrowband imaging scoring system for a differential diagnosis of colorectal lesions.
abstract: Narrowband imaging (NBI) allows characterization of colorectal polyps during endoscopy; however, this is underutilized by most US physicians. The aim of this study was to assess diagnostic performance of an NBI scoring system, based on the NBI international colorectal endoscopic classification, and determine a threshold score yielding the highest negative predictive value (NPV) in the characterization of colorectal neoplasia.
  
  
  
  During colonoscopy, colorectal lesions were scored using the NBI scoring system on a 0-3 scale for NBI findings. All lesions were biopsied or endoscopically removed for pathological examinations.
  
  
  
  Two hundred and three patients were enrolled, and a total of 156 colorectal lesions were detected in 67 patients. Diagnostic yields under white light mode showed limited diagnostic performance [accuracy 75.6 % (68.9-82.3), sensitivity 69.2 % (58.6-78.3), specificity 84.6 % (73.1-92.0), positive predictive value (PPV) 86.3 % (75.8-92.9), NPV 66.3 % (55.0-76.0)]. Of NBI threshold scores from 1 to 3 for the diagnosis of neoplastic lesion, the score of ≥1 resulted in an accuracy of 88.5 % (83.5-93.5), sensitivity of 97.8 % (91.5-96.6), and specificity of 75.4 % (62.9-84.9), with PPV of 84.8 % (76.1-90.8) and NPV of 96.1 % (85.4-99.3).
  
  
  
  The threshold value of ≥1 in this simplified NBI scoring system yielded the highest sensitivity and NPV for non-adenomatous colorectal polyps. This scoring system is simple to apply and is superior to white light endoscopy.
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis St., Thorn 1404, Boston, MA, 02115, USA. haihara@bwh.harvard.edu.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Aihara
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis St., Thorn 1404, Boston, MA, 02115, USA.
authors.forename: Nitin
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis St., Thorn 1404, Boston, MA, 02115, USA.
authors.forename: Marvin
authors.initials: M
authors.lastname: Ryou
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis St., Thorn 1404, Boston, MA, 02115, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Burakoff
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis St., Thorn 1404, Boston, MA, 02115, USA.
authors.forename: Marwan Abou
authors.initials: MA
authors.lastname: Gergi
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis St., Thorn 1404, Boston, MA, 02115, USA.
authors.forename: Michele B
authors.initials: MB
authors.lastname: Ryan
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis St., Thorn 1404, Boston, MA, 02115, USA.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Thompson
mesh_terms: D000368:Aged; D001706:Biopsy; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods* / Q000592:standards; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity
keywords: Colorectal polyp; Narrowband imaging; Optical biopsy; Scoring system