title: Neurohumoral Integration of Cardiovascular Function by the Lamina Terminalis.
abstract: The mechanisms involved in cardiovascular regulation, such as vascular tone, fluid volume and blood osmolarity, are quite often mediated by signals circulating in the periphery, such as angiotensin II and sodium concentration. Research has identified areas within the lamina terminalis (LT), specifically the sensory circumventricular organs (CVOs), the subfornical organ and the organum vasculosum of the lamina terminalis, as playing crucial roles detecting and integrating information derived from these circulating signals. The median preoptic nucleus (MnPO) is a third integrative structure within the LT that influences cardiovascular homeostasis, although to date, its role is not as clearly elucidated. More recent studies have demonstrated that the CVOs are not only essential in the detection of traditional cardiovascular signals but also signals primarily considered to be important in the regulation of metabolic, reproductive and inflammatory processes that have now also been implicated in cardiovascular regulation. In this review, we highlight the critical roles played by the LT in the detection and integration of circulating signals that provide critical feedback control information contributing to cardiovascular regulation.
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, K7L 3N6, Canada.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Cancelliere
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, K7L 3N6, Canada.
authors.forename: Emily A E
authors.initials: EA
authors.lastname: Black
authors.affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, K7L 3N6, Canada. avf@queensu.ca.
authors.forename: Alastair V
authors.initials: AV
authors.lastname: Ferguson
mesh_terms: D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007031:Hypothalamus / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism
chemical_list: D012964:Sodium
keywords: Cardiovascular regulation; Circumventricular organs; Lamina terminalis; Organum vasculosum of the lamina terminalis; Signal integration; Subfornical organ