title: Increased chemerin and decreased omentin-1 levels in morbidly obese patients are correlated with insulin resistance, oxidative stress and chronic inflammation.
abstract: OBJECTIVE
  Morbid obesity represents a proinflammatory and pro-oxidative state associated with dysregulation of adipokines. We aimed to evaluate the circulating levels of chemerin and omentin-1 in morbidly obese (MO) patients and to investigate the relationship between these two adipokines and between each of them and anthropometric, metabolic, oxidative stress and chronic inflammatory parameters.
  
  
  METHODS
  32 MO patients and 20 controls were investigated in this study. Anthropometric, metabolism parameters, inflammatory markers, oxidative stress indicators as well as chemerin and omentin-1 were measured.
  
  
  RESULTS
  Serum levels of chemerin were increased while omentin-1 levels were decreased in MO patients when compared with controls. Chemerin correlated positively with insulin, HOMA-IR, LDL cholesterol and negatively with total antioxidant response. Omentin-1 correlated negatively with tumor necrosis factor alpha and total cholesterol. In a multiple linear stepwise regression analysis we learnt that only HOMA-IR (β=0.70, p<0.001), total cholesterol (β=0.42, p<0.001) and triglycerides (β=0.31, p<0.05) remained significantly associated with chemerin changes. Using the same analysis we noticed that total cholesterol (β=-0.71, p<0.001), fasting glucose (β= -0.40, p<0.05) and body mass index (BMI) (β= -0.38, p<0.05) were considered to be significant predictors for omentin-1 changes.
  
  
  CONCLUSIONS
  Chemerin and omentin-1 synthesis was dysregulated in MO patients. Chemerin might play a role in insulin resistance and oxidative stress. Chemerin changes seemed to be predicted mainly by insulin resistance. Omentin-1 levels were inversely associated with chronic inflammation and dyslipidemia while the main modulating factors seemed to be dyslipidemia, hyperglycemia and BMI.
authors.affiliation: Department of Physiology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.
authors.forename: Adriana Florinela
authors.initials: AF
authors.lastname: Cătoi
authors.affiliation: Department of Physiology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.
authors.forename: Şoimiţa
authors.initials: Ş
authors.lastname: Suciu
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.
authors.forename: Alina Elena
authors.initials: AE
authors.lastname: Pârvu
authors.affiliation: Bariatric Center of Excellence (BariXL) "Ponderas" (Delta) Hospital, Bucharest, Romania.
authors.forename: Cătălin
authors.initials: C
authors.lastname: Copăescu
authors.affiliation: Second Surgical Clinic, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.
authors.forename: Romeo Florin
authors.initials: RF
authors.lastname: Galea
authors.affiliation: Department of Pharmacology, Faculty of Medicine "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.
authors.forename: Anca Dana
authors.initials: AD
authors.lastname: Buzoianu
authors.affiliation: Clinical Center of Diabetes, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.
authors.forename: Ioan Andrei
authors.initials: IA
authors.lastname: Vereşiu
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Romania.
authors.forename: Cornel
authors.initials: C
authors.lastname: Cătoi
authors.affiliation: Department of Exact Sciences, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Romania.
authors.forename: Ioana Delia
authors.initials: ID
authors.lastname: Pop
keywords: adipokines; chronic inflammation; morbid obesity; oxidative stress