title: Targeting post-translational modifications of histones for cancer therapy.
abstract: Post-translational modifications (PTMs) on histones including acetylation, methylation, phosphorylation, citrullination, ubiquitination, ADP ribosylation, and sumoylation, play important roles in different biological events including chromatin dynamics, DNA replication, and transcriptional regulation. Aberrant histones PTMs leads to abnormal gene expression and uncontrolled cell proliferation, followed by development of cancers. Therefore, targeting the enzymes required for specific histone PTMs holds a lot of potential for cancer treatment. In this review article, we retrospect the latest studies in the regulations of acetylation, methylation, and phosphorylation of histones. We also summarize inhibitors/drugs that target these modifications for cancer treatment.
authors.affiliation: Mackay Medical College Institute of Biomedical Sciences New Taipei City Taiwan.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Hsu
authors.affiliation: Chung Shan Medical University Department of Biochemistry, School of Medicine Taichung Taiwan.
authors.forename: Y-H
authors.initials: YH
authors.lastname: Hsieh
authors.affiliation: National Yang&mdash;Ming University Proteomics Research Center Taipei Taiwan.
authors.forename: C-C
authors.initials: CC
authors.lastname: Liao
authors.affiliation: Shin Kong Wu Ho&mdash;Su Memorial Hospital Division of Hepatology and Gastroenterology, Department of Internal Medicine Taipei Taiwan.
authors.forename: L-W
authors.initials: LW
authors.lastname: Chong
authors.affiliation: I&mdash;Shou University School of Chinese Medicine for Post&mdash;Baccalaureate Kaohsiung Taiwan.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Lee
authors.affiliation: China Medical University Graduate Institute of Cancer Biology and Center for Molecular Medicine Taichung Taiwan ylyu&commat;mail.cmu.edu.tw.
authors.forename: Y-L
authors.initials: YL
authors.lastname: Yu
authors.affiliation: China Medical University Graduate Institute of Cancer Biology and Center for Molecular Medicine Taichung Taiwan rhchou&commat;mail.cmu.edu.tw.
authors.forename: R-H
authors.initials: RH
authors.lastname: Chou
mesh_terms: D000107:Acetylation; D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000187:drug effects
chemical_list: D006657:Histones; D006655:Histone Deacetylases