title: Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children.
abstract: Probiotics are foods or products that contain live microorganisms that benefit the host when administered. In this clinical review, we evaluate the literature associated with using probiotics in common pediatric gastrointestinal disorders, focusing specifically on antibiotic-associated diarrhea, acute gastroenteritis, Clostridium difficile infection (CDI), colic, inflammatory bowel disease, and functional gastrointestinal diseases. Meta-analysis of several randomized controlled trials have confirmed benefit for the administration of Lactobacillus rhamnosus GG and Saccharomyces boulardii to prevent antibiotic-associated diarrhea and to treat acute infectious diarrhea. Individual studies have also suggested benefit of probiotics to prevent acute gastroenteritis and serve as an adjunct in ulcerative colitis, pouchitis, antibiotic-associated diarrhea, CDI, functional abdominal pain, irritable bowel syndrome, and colic in breastfed babies. Although promising, larger well-designed studies need to confirm these findings. There is currently insufficient evidence to recommend probiotics for the treatment of constipation-predominant irritable bowel syndrome or Crohn's disease.
authors.affiliation: Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford Children's Health, Stanford University, Palo Alto, California.
authors.forename: Danielle
authors.initials: D
authors.lastname: Barnes
authors.affiliation: Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford Children's Health, Stanford University, Palo Alto, California annming@stanford.edu.
authors.forename: Ann Ming
authors.initials: AM
authors.lastname: Yeh
mesh_terms: D002648:Child; D002675:Child, Preschool; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007223:Infant; D019936:Probiotics / Q000627:therapeutic use*
keywords: diarrhea; gastroenteritis; inflammatory bowel diseases; irritable bowel syndrome; microbiota; pediatrics; prebiotics; probiotics