title: Clinical Characteristics of Gestational Trophoblastic Neoplasia: A 15-Year Hospital-Based Study.
abstract: OBJECTIVE
  To analyze the clinical profile of invasive mole (IM) and choriocarcinoma (CCA) in the past 15 years in Western China.
  
  
  METHODS
  A retrospective study was performed on 221 patients with IM and 70 patients with CCA treated in the First Affiliated Hospital of Xi'an Jiaotong University from 1994 to 2009. Patients were assigned into 3 groups by 5 years, and the clinical characteristics were compared among these groups.
  
  
  RESULTS
  The incidence was not significantly changed in the past 15 years, whereas the mean age of gestational trophoblastic neoplasia (GTN) was increased significantly, especially for the patients 40 years or older. The symptoms of the patients with GTN did not show significant variation, but the number of patients with CCA without clinical symptoms was increased significantly. The mean values of beta human chorionic gonadotropin in the patients with IM and those with CCA were 459.43 and 661.70 mIu/L, respectively, and the size of uterine lesion was concentrated at 4 cm or less in both the patients with IM and those with CCA, without significant differences.
  
  
  CONCLUSIONS
  In the past 15 years, the incidence of GTN was still higher than in other countries from 1994 to 2009, and the mean age of patients with GTN was increased significantly, especially for the patients older than 40 years. Furthermore, patients with no clinical manifestations increased significantly, which should be paid more attention in the future works. Serum level of beta human chorionic gonadotropin and pelvic ultrasonography are still 2 important indexes for diagnosing and monitoring condition of GTN.
authors.affiliation: *Department of Gynecology and Obstetrics, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; †Department of Gynecology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Sun
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Quan
authors.initials: Q
authors.lastname: Tian
authors.forename: Ruifang
authors.initials: R
authors.lastname: An
authors.forename: Yan
authors.initials: Y
authors.lastname: Xue
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D002822:Choriocarcinoma / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D031901:Gestational Trophoblastic Disease / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009367:Neoplasm Staging; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D014594:Uterine Neoplasms / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin