title: Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus.
abstract: BACKGROUND
  The treatment options for oral lichen planus (OLP) are numerous and include topical and systemic agents. Intralesional and systemic corticosteroids are used; however, the therapeutic results are often disappointing.
  
  
  OBJECTIVE
  To compare the influence of ozone, laser, and topical corticosteroid therapies in the treatment of OLP.
  
  
  METHODS
  One hundred twenty adult patients with ≤3 cm atrophic-erosive biopsy-proven OLPs in the tongue or buccal mucosa were recruited into the study. They were randomly assigned, by preoperative envelope drawing, to be treated with low-level laser therapy (LLLT group), ozone therapy (ozonated group), and topical corticosteroid therapy (positive control group). A placebo treatment containing base ointment without the active corticosteroid component was administered to patients in the negative control group. Response rate scores were determined on the basis of changes in the appearance score and pain score of the lesions between baseline and after each treatment.
  
  
  RESULTS
  The study subjects consisted of 56 male and 64 female OLP patients with a combined mean age of 42.6±8.3 years (range, 28~55 years). No statistically significant difference was detected in clinical severity among the groups. The sign scores decreased in almost all scoring groups; however, statistically significant improvement was found in the ozonated and corticosteroid-treated groups. Symptom improvement was achieved after treatment with LLLT, ozone, and corticosteroid (p<0.05). The efficacy indices were significantly higher in the ozonated and corticosteroid-treated groups.
  
  
  CONCLUSIONS
  Ozone and corticosteroid therapies were more effective than 808-nm LLLT in the treatment of OLP.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Hakki Oguz
authors.initials: HO
authors.lastname: Kazancioglu
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Erisen
keywords: Dentistry; Lasers; Lichen planus; Ozone; Pain