title: [Progress in Research on Structure, Function and Antiviral of Enterovirus A71 3C Protein].
abstract: Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease (HFMD) and various neurological complications, including aseptic meningitis and neurogenic pulmonary edema in young children. HFMD caused by EV-A71 have broken out several times in the Asia-Pacific region since 2007. And it has been a serious threat to public health. There is no effective vaccine or antiviral drug. The pathogenesis of EV-A71 infection is unknown, and EV-A71 3C protein plays an irreplaceable role in replication and anti - innate immunity. Further research on EV-A71 3C protein is conducive to understand the pathogenesis of EV-A71 infection and antiviral drug.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Hongling
authors.initials: H
authors.lastname: Wen
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D004770:Enterovirus / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins