title: Marine Diterpenoids as Potential Anti-Inflammatory Agents.
abstract: The inflammatory response is a highly regulated process, and its dysregulation can lead to the establishment of chronic inflammation and, in some cases, to death. Inflammation is the cause of several diseases, including rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and asthma. The search for agents inhibiting inflammation is a great challenge as the inflammatory response plays an important role in the defense of the host to infections. Marine invertebrates are exceptional sources of new natural products, and among those diterpenoids secondary metabolites exhibit notable anti-inflammatory properties. Novel anti-inflammatory diterpenoids, exclusively produced by marine organisms, have been identified and synthetic molecules based on those structures have been obtained. The anti-inflammatory activity of marine diterpenoids has been attributed to the inhibition of Nuclear Factor-κB activation and to the modulation of arachidonic acid metabolism. However, more research is necessary to describe the mechanisms of action of these secondary metabolites. This review is a compilation of marine diterpenoids, mainly isolated from corals, which have been described as potential anti-inflammatory molecules.
authors.affiliation: Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad de Panamá, Panama ; Department of Biotechnology, Acharya Nagarjuna University, Guntur 522510, India.
authors.forename: Yisett
authors.initials: Y
authors.lastname: González
authors.affiliation: Department of Biotechnology, Acharya Nagarjuna University, Guntur 522510, India ; Centro de Descubrimiento de Drogas y Biodiversidad, INDICASAT AIP, Ciudad de Panamá, Panama.
authors.forename: Daniel
authors.initials: D
authors.lastname: Torres-Mendoza
authors.affiliation: Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad de Panamá, Panama.
authors.forename: Gillian E
authors.initials: GE
authors.lastname: Jones
authors.affiliation: Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad de Panamá, Panama.
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Fernandez
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000378:metabolism; D001688:Biological Products / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology*; D005938:Glucocorticoids / Q000737:chemistry; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D001688:Biological Products; D004224:Diterpenes; D005938:Glucocorticoids; D016328:NF-kappa B; D016718:Arachidonic Acid