title: Nociceptive Reactions in Rats during Repeated Stress Exposure.
abstract: Changes in nociceptive sensitivity of rats with various behavioral patterns in the open-field test were studied after repeated stress exposure on the model of daily 4-h immobilization for 8 days. The tail-flick latency in response to light-heat stimulation in passive and active specimens decreased most significantly on days 2 and 7, respectively. However, this parameter did not differ from the baseline on day 8 of observations. Vocalization threshold during electrocutaneous stimulation in behaviorally active animals did not change over the first 7 days of repeated stress exposure, but increased significantly on day 8 of the study. The emotional component of nociception in passive animals increased on day 3, but decreased on days 4 and 6 of the experiment. Therefore, repeated stress exposure in rats is mainly accompanied by an increase in the perceptual component of nociception. Variations in the emotional component of nociceptive sensitivity after stress loads are manifested in the initial increase and subsequent decrease in this parameter. The observed changes are more pronounced in behaviorally passive rats than in active animals. These data illustrate the specifics of stress-induced changes in nociception of specimens with various individual and typological characteristics. Our results hold much promise for the development of new individual approaches to modulation of pain sensitivity in humans under conditions of negative emotiogenic exposures.
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation. brama@mail.ru.|A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation, Moscow, Russia. brama@mail.ru.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Kozlov
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation.|A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Abramova
authors.affiliation: A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Chekhlov
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation.
authors.forename: O S
authors.initials: OS
authors.lastname: Grigorchuk
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russian Federation.|A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Pertsov
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D008297:Male; D059225:Nociception / Q000502:physiology*; D017288:Pain Threshold / Q000502:physiology / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D012008:Recurrence; D013315:Stress, Psychological / Q000503:physiopathology*
keywords: emotional and perceptual components of nociception; rats; repeated stress exposure