title: A Decision Tree Based Classifier to Analyze Human Ovarian Cancer cDNA Microarray Datasets.
abstract: Ovarian cancer is the deadliest gynaecological disease because of the high mortality rate and there is no any symptom in cancer early stage. It was often the terminal cancer period when patients were diagnosed with ovarian cancer and thus delays a good opportunity of treatment. The current common method for detecting ovarian cancer is blood testing for analyzing the tumor marker CA-125 of serum. However, specificity and sensitivity of CA-125 are insufficient for early detection. Therefore, it has become an urgent issue to look for an efficient method which precisely detects the tumor markers for ovarian cancer. This study aims to find the target genes of ovarian cancer by different algorithms of information science. Feature selection and decision tree were applied to analyze 9600 ovarian cancer-related genes. After screening the target genes, candidate genes will be analyzed by Ingenuity Pathway Analysis (IPA) software to create a genetic pathway model and to understand the interactive relationship in the different pathological stages of ovarian cancer. Finally, this research found 9 oncogenes associated with ovarian cancer and some genes had not been discovered in previous studies. This system will assist medical staffs in diagnosis and treatment at cancer early stage and improve the patient's survival.
authors.affiliation: Department of Management Information System, National Chung Hsing University, No.250, Kuo Kuang Rd., Taichung City, 402, Taiwan. mht@nchu.edu.tw.|Institute of Genomics and Bioinformatics, National Chung Hsing University, No.250, Kuo Kuang Rd., Taichung City, 402, Taiwan. mht@nchu.edu.tw.
authors.forename: Meng-Hsiun
authors.initials: MH
authors.lastname: Tsai
authors.affiliation: Department of Management Information System, National Chung Hsing University, No.250, Kuo Kuang Rd., Taichung City, 402, Taiwan. d89623601@ntu.edu.tw.
authors.forename: Hsin-Chieh
authors.initials: HC
authors.lastname: Wang
authors.affiliation: Department of Management Information System, National Chung Hsing University, No.250, Kuo Kuang Rd., Taichung City, 402, Taiwan. g102029018@mail.nchu.edu.tw.
authors.forename: Guan-Wei
authors.initials: GW
authors.lastname: Lee
authors.affiliation: Department of Management Information System, National Chung Hsing University, No.250, Kuo Kuang Rd., Taichung City, 402, Taiwan. lucius119xd@gmail.com.
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Troilus Bio-Technology Co. Ltd., Taiwan, Republic of China.
authors.forename: Sheng-Hsiung
authors.initials: SH
authors.lastname: Chiu
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor; D003663:Decision Trees; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor
keywords: C&RT; CHAID; Decision tree; Ingenuity Pathway Analysis; Ovarian cancer