title: Hyperbaric oxygen as salvage treatment for idiopathic sudden sensorineural hearing loss.
abstract: OBJECTIVE
  To investigate the efficacy of hyperbaric oxygen therapy as a salvage treatment for patients with sudden sensorineural hearing loss (SSHL).
  
  
  METHODS
  Fifteen patients affected by sudden hearing loss and treated with hyperbaric oxygen after steroid and vasodilator therapy failed constituted the study group. A control group of 30 patients who were treated with steroids and vasodilator alone was also included. Hyperbaric oxygen was administered once daily for 15 sessions at a constant pressure of 2.2 atmospheres. Pure-tone hearing thresholds were obtained for both groups before and after each treatment and frequency-specific thresholds 3 months after the end of hyperbaric oxygen therapy.
  
  
  RESULTS
  Salvage hyperbaric oxygen therapy was performed with a mean delay of 24 days from the onset of SSHL. The overall rate of hearing improvement was higher in the study group (7/15 cases, 46.6%) compared with the control group (4/30 cases, 13.3%). The mean pure-tone hearing average thresholds after salvage treatment in the study group was 53.4 dB HL (mean gain, 12.1 dB HL), which was significantly lower than that in the control group of 67.9 dB HL (mean gain, 2.7 dB HL). Hearing recovery was found to be better at low frequencies (250-500 Hz).
  
  
  CONCLUSIONS
  Hyperbaric oxygen therapy should be suggested to all patients for whom initial conventional medical treatment for SSHL has failed.
authors.forename: G
authors.initials: G
authors.lastname: Psillas
authors.forename: S
authors.initials: S
authors.lastname: Ouzounidou
authors.forename: S
authors.initials: S
authors.lastname: Stefanidou
authors.forename: M
authors.initials: M
authors.lastname: Kotsiou
authors.forename: G D
authors.initials: GD
authors.lastname: Giaglis
authors.forename: I
authors.initials: I
authors.lastname: Vital
authors.forename: M
authors.initials: M
authors.lastname: Tsalighopoulos
authors.forename: K
authors.initials: K
authors.lastname: Markou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D003639:Hearing Loss, Sudden / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016879:Salvage Therapy; D055815:Young Adult