title: Chrysin suppresses human CD14(+) monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis.
abstract: Chrysin, a naturally flavonoid of plant, has various biological activities. However, the effects of chrysin on dendritic cells (DCs) and multiple sclerosis (MS) remain unknown. In this study, we demonstrate that chrysin inhibited human DC differentiation, maturation, function and the expression of the Th1 cells polarizing cytokines IFN-γ and IL-12p35 form DCs. In addition, chrysin ameliorated experimental autoimmune encephalomyelitis (EAE), an animal model of MS, by reducing CNS inflammation and demyelination. Furthermore, chrysin suppressed DCs and Th1 cells in the EAE mice. Taken together, chrysin exerts anti-inflammatory and immune suppressive effects, and suggests a possible therapeutic application of chrysin in MS.
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Hormones and Development, Ministry of Health, Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Ge
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Zhenyi
authors.initials: Z
authors.lastname: Xue
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Huang
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Mei
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China.
authors.forename: Zimu
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China.
authors.forename: Huafeng
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Immunology and Transplantation, Tianjin First Central Hospital, Tianjin 300192, China.
authors.forename: Jinzhen
authors.initials: J
authors.lastname: Cai
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yao
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Hormones and Development, Ministry of Health, Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China. Electronic address: rongxinz@yahoo.com.
authors.forename: Rongxin
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Basic Medical College, Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China. Electronic address: dayr@tmu.edu.cn.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Da
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D004705:Endocytosis / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D018950:Lipopolysaccharide Receptors / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008810:Mice, Inbred C57BL; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D005419:Flavonoids; D007166:Immunosuppressive Agents; D018950:Lipopolysaccharide Receptors; C043561:chrysin
keywords: Chrysin; Dendritic cells; Experimental autoimmune encephalomyelitis; Inflammation; Multiple sclerosis