title: [Meta analysis of the changes of blood coagulation in patients with active ulcerative colitis].
abstract: OBJECTIVE
  To evaluate the changes of blood coagulation in patients with active ulcerative colitis.
  
  
  METHODS
  We searched the PubMed, Medline, EMBASE, Web of Science, the Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Wanfang Database for the Chinese or English literatures published until January 2015. The data that met the inclusion criteria were screened and evaluated. After evaluation, the eligible ones were subjected to Newcastle-Ottawa Scale (NOS) and meta analysis using the Stata12.0 software.
  
  
  RESULTS
  A total of 28 case-control studies were recruited for the meta analysis. The analysis results showed that the levels of platelet (PLT), fibrinogen (FIB) and D-dimer significantly increased in active ulcerative colitis group compared with normal control group. The levels of mean platelet volume (MPV) and prothrombin time (PT) significantly decreased in active ulcerative colitis group compared with normal control group. Sensitivity analysis showed that the evaluation result was stable. Egger and Begg tests suggested no evidence of substantial publication bias except for the literatures about D-dimer.
  
  
  CONCLUSIONS
  Abnormal blood coagulation indexes of active ulcerative colitis patients indicate there may be high coagulation state in ulcerative colitis.
authors.affiliation: Department of Gastroenterology, First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230038, China.
authors.forename: Ansheng
authors.initials: A
authors.lastname: Zha
authors.affiliation: Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Hunan University of Traditional Chinese Medicine, Changsha 410208, China.
authors.forename: Ruiyao
authors.initials: R
authors.lastname: Zha
mesh_terms: D001777:Blood Coagulation; D003093:Colitis, Ulcerative / Q000097:blood*; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D063847:Mean Platelet Volume; D010314:Partial Thromboplastin Time; D010976:Platelet Count
chemical_list: D005340:Fibrinogen