title: Multimorbidities and Overprescription of Proton Pump Inhibitors in Older Patients.
abstract: OBJECTIVE
  To determine whether there is an association between overprescription of proton pump inhibitors (PPIs) and multimorbidities in older patients.
  
  
  METHODS
  Multicenter prospective study.
  
  
  METHODS
  Acute geriatric medicine at the University Hospital of Nantes and the Hospital of Saint-Nazaire.
  
  
  METHODS
  Older patients aged 75 and over hospitalized in acute geriatric medicine.
  
  
  METHODS
  Older patients in acute geriatric medicine who received proton pump inhibitors. Variables studied were individual multimorbidities, the burden of multimorbidity evaluated by the Cumulative Illness Rating Scale, age, sex, type of residence (living in nursing home or not), functional abilities (Lawton and Katz scales), nutritional status (Body Mass Index), and the type of concomitant medications (antiaggregant, corticosteroids', or anticoagulants).
  
  
  RESULTS
  Overprescription of proton pump inhibitors was found in 73.9% older patients. In the full model, cardiac diseases (odds ratio [OR] = 4.17, p = 0.010), metabolic diseases (OR = 2.14, p = 0.042) and corticosteroids (OR = 5.39, p = 0.028) were significantly associated with overprescription of proton pump inhibitors. Esogastric diseases (OR = 0.49, p = 0.033) were negatively associated with overprescription of proton pump inhibitors.
  
  
  CONCLUSIONS
  Cardiac diseases and metabolic diseases were significantly associated with overprescription of proton pump inhibitors.
authors.affiliation: Department of Geriatrics, Saint-Nazaire Hospital, Saint-Nazaire, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Delcher
authors.affiliation: Department of Geriatrics, Saint-Nazaire Hospital, Saint-Nazaire, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Hily
authors.affiliation: Department of Geriatrics, Nantes University Hospital, Nantes, France.
authors.forename: Anne Sophie
authors.initials: AS
authors.lastname: Boureau
authors.affiliation: Department of Geriatrics, Nantes University Hospital, Nantes, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Chapelet
authors.affiliation: Department of Geriatrics, Nantes University Hospital, Nantes, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Berrut
authors.affiliation: Department of Geriatrics, Nantes University Hospital, Nantes, France.
authors.forename: Laure
authors.initials: L
authors.lastname: de Decker
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D006331:Heart Diseases / Q000188:drug therapy / Q000473:pathology; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008659:Metabolic Diseases / Q000188:drug therapy / Q000473:pathology; D016017:Odds Ratio; D000067490:Prescription Drug Overuse / Q000706:statistics & numerical data; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012737:Sex Factors
chemical_list: D000305:Adrenal Cortex Hormones; D054328:Proton Pump Inhibitors