title: Improving the diagnosis and management of GORD in adults.
abstract: Gastro-oesophageal reflux disease (GORD) is defined as a condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Many patients with GORD complications such as oesophagitis, and up to a third of patients with Barrett's oesophagus have no reflux or heartburn symptoms. Conversely, patients can be symptomatic even when normal reflux levels are found and there is an absence of mucosal damage. Significant GORD symptoms occur at least once a week in 8.8-26% of Europeans, with equal prevalence of symptoms in men and women. The frequency and severity of symptoms do not accurately predict the degree of oesophageal damage. If patients with GORD also describe symptoms of dyspepsia this should be considered first with H. py/oritesting or direct referral for gastroscopy if the patient is over 55 given the risk of gastric cancer in these patients. Oesophageal disease can account for up to 20% of cases of chronic cough. Symptoms of GORD occur in more than 45% of patients with asthma, and erosive oesophagitis on endoscopy has a 50% higher likelihood of a diagnosis of asthma. GORD is a risk factor for Barrett's oesophagus and oesophageal adenocarcinoma. The risk increases with duration, severity and frequency. Endoscopy should not be routinely offered at initial presentation unless the patient has dysphagia or other symptoms suggestive of upper GI cancer. Smoking cessation and weight loss are beneficial in reducing GORD symptoms. Abdominal obesity causes GORD by elevating intra-abdominal pressure, which promotes reflux and the development of hiatus hernia. GORD symptoms are increased by 70% among daily smokers who have been smoking for more than 20 years.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hopper
mesh_terms: D000328:Adult; D001471:Barrett Esophagus / Q000209:etiology / Q000517:prevention & control; D003937:Diagnosis, Differential; D019468:Disease Management; D004415:Dyspepsia / Q000209:etiology; D016145:Endoscopy, Digestive System / Q000379:methods; D004941:Esophagitis / Q000209:etiology / Q000517:prevention & control; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006356:Heartburn / Q000209:etiology; D016481:Helicobacter Infections / Q000175:diagnosis*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000175:diagnosis*
chemical_list: D054328:Proton Pump Inhibitors