title: Isolated proteinuria is a risk factor for pre-eclampsia: a retrospective analysis of the maternal and neonatal outcomes in women presenting with isolated gestational proteinuria.
abstract: OBJECTIVE
  To examine maternal and neonatal outcomes of isolated proteinuria and define maternal characteristics for progression to pre-eclampsia.
  
  
  METHODS
  Retrospective cohort study. Data from all hospitalized pregnant women between 2009 and 2014 with new onset isolated proteinuria of over 300 mg/24 h at admission were obtained. Follow-up was performed from the time of admission to the hospital to the time of discharge postpartum. Obstetrical, maternal and neonatal outcomes were obtained.
  
  
  RESULTS
  Ninety-five pregnant women diagnosed with new onset isolated proteinuria were followed to term. Thirteen women developed pre-eclampsia during pregnancy and eight developed pre-eclampsia postpartum. Maternal characteristics for progression to pre-eclampsia were greater maximal values of proteinuria. Earlier pre-eclampsia onset was associated with early-onset proteinuria and multiple gestation. Although greater values of proteinuria were associated with increased risk for intrauterine growth restriction and lower Apgar scores, maternal outcome was favorable, regardless of pre-eclampsia progression. Isolated proteinuria progressing to pre-eclampsia was associated with late pre-eclampsia onset and favorable maternal and neonatal outcomes.
  
  
  CONCLUSIONS
  A significant proportion of women with new onset isolated proteinuria will develop pre-eclampsia. In these women, close follow-up is recommended until after delivery.
authors.affiliation: Lis Maternity Hospital, Department of Obstetrics and Gynecology, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Shinar
authors.affiliation: Lis Maternity Hospital, Department of Obstetrics and Gynecology, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Asher-Landsberg
authors.affiliation: Lis Maternity Hospital, Department of Obstetrics and Gynecology, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Schwartz
authors.affiliation: Lis Maternity Hospital, Department of Obstetrics and Gynecology, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Ram-Weiner
authors.affiliation: Lis Maternity Hospital, Department of Obstetrics and Gynecology, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kupferminc
authors.affiliation: Lis Maternity Hospital, Department of Obstetrics and Gynecology, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Many
mesh_terms: D000328:Adult; D001794:Blood Pressure; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007557:Israel; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000652:urine*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000652:urine*; D011256:Pregnancy Outcome; D011507:Proteinuria / Q000175:diagnosis*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult