title: Propofol versus thiopental sodium as anaesthetic agents for oocyte retrieval: a randomized controlled trial.
abstract: Clinical outcomes of IVF cycles using propofol or thiopental sodium as anaesthetic agents for oocyte retrieval were compared. The primary outcome measure was fertilization rate per patient. One hundred and eighty patients undergoing ovarian stimulation with gonadotrophins and gonadotrophin-releasing hormone antagonists for IVF were randomized to receive either propofol (n = 90) or thiopental sodium (n = 90). No significant differences in baseline characteristics were present between the two groups. Overall fertilization rates were similar between propofol and thiopental sodium groups, respectively: median (IQR): 54.8 (29.2) versus 54.6 (29.7); fertilization rates for intracytoplasmic sperm injection only: median (IQR): 70 (50) versus 75 (50), respectively. For secondary outcome measures, time under anaesthesia was significantly increased in the thiopental sodium group: median (IQR): 12(5) versus 10 (4.5) min, P = 0.019 compared with the propofol group. Number of cumulus oocyte complexes retrieved [median (IQR): 7.1 (6.3) versus 6.5 (5.6)] did not differ significantly between the two groups. A non-significant difference in live birth rates per randomized patient of +4.4% (95% CI: -5.7 to +14.6) in favour of propofol was observed. Use of propofol compared with thiopental sodium for general anaesthesia during oocyte retrieval results in similar fertilization rates and IVF outcomes.
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Goutziomitrou
authors.affiliation: Women's and Children's Health, St George Hospital, University of New South Wales, NSW, Australia.
authors.forename: Christos A
authors.initials: CA
authors.lastname: Venetis
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Greece. Electronic address: stratis.kolibianakis@gmail.com.
authors.forename: Efstratios M
authors.initials: EM
authors.lastname: Kolibianakis
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: Julia K
authors.initials: JK
authors.lastname: Bosdou
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: Aggeliki
authors.initials: A
authors.lastname: Parlapani
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: Gregoris
authors.initials: G
authors.lastname: Grimbizis
authors.affiliation: Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Greece.
authors.forename: Basil C
authors.initials: BC
authors.lastname: Tarlatzis
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects / Q000379:methods*; D000777:Anesthetics / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth / Q000453:epidemiology; D054315:Oocyte Retrieval / Q000379:methods*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D015742:Propofol / Q000627:therapeutic use*; D013874:Thiopental / Q000627:therapeutic use*
chemical_list: D000777:Anesthetics; D013874:Thiopental; D015742:Propofol
keywords: IVF; fertilization rate; oocyte retrieval; propofol; thiopental sodium