title: Modulation of nuclear PI-PLCbeta1 during cell differentiation.
abstract: PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, osteogenesis and hematopoiesis. Indeed, the increase of PI-PLCbeta1, along with Cyclin D3, has been detected in C2C12 mouse myoblasts induced to differentiate, as well as in human cells obtained from myotonic dystrophy. Also in the case of osteogenic differentiation there is a specific induction of PI-PLCbeta1, but in this case the role of PI-PLCbeta1 seems to be independent from Cyclin D3, so that a different mechanism could be involved. As for the hematopoietic system, PI-PLCbeta1 has a peculiar behavior: it increases during myeloid differentiation and decreases during erythroid differentiation, thus confirming the role of PI-PLCbeta1 as a modulator of hematopoiesis.
authors.affiliation: Department of Biomedical and Neuromotor Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Cocco
authors.affiliation: Department of Biomedical and Neuromotor Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Manzoli
authors.affiliation: Department of Biomedical and Neuromotor Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Faenza
authors.affiliation: Department of Biomedical and Neuromotor Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ramazzotti
authors.affiliation: School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
authors.forename: Yong Ryoul
authors.initials: YR
authors.lastname: Yang
authors.affiliation: Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: McCubrey
authors.affiliation: School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
authors.forename: Pann-Ghill
authors.initials: PG
authors.lastname: Suh
authors.affiliation: Department of Biomedical and Neuromotor Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy. Electronic address: matilde.follo@unibo.it.
authors.forename: Matilde Y
authors.initials: MY
authors.lastname: Follo
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000166:cytology / Q000201:enzymology*; D056743:Cyclin D3 / Q000235:genetics / Q000378:metabolism; D006410:Hematopoiesis; D006801:Humans; D051379:Mice; D032446:Myoblasts / Q000166:cytology / Q000201:enzymology*; D010012:Osteogenesis; D054799:Phospholipase C beta / Q000235:genetics / Q000378:metabolism*
chemical_list: D056743:Cyclin D3; D054799:Phospholipase C beta
keywords: Differentiation; Hematopoiesis; Myogenesis; Osteogenesis; PI-PLCbeta1