title: Sustained lung inflation at birth: what do we know, and what do we need to know?
abstract: A sustained inflation has been advocated as a potential method of augmenting lung aeration at birth. Clinical trials have suggested that a sustained inflation may lead to a reduced need for intubation and ventilation in the first few days of life, without cardiovascular compromise or increased lung injury. Despite this, a sustained inflation is not currently a standard of practice, mainly due to a lack of clarity regarding the optimal delivery method. Animal trials have sought to refine delivery techniques. This review will outline current recommendations regarding a sustained inflation, discuss potential strategies for its optimal delivery and suggest priorities for future research.
authors.affiliation: Newborn Research, Murdoch Children's Research Institute, Melbourne, Australia School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
authors.forename: Karen E
authors.initials: KE
authors.lastname: McCall
authors.affiliation: Newborn Research, Murdoch Children's Research Institute, Melbourne, Australia Department of Obstetrics, University of Melbourne, Melbourne, Australia Neonatal Research, Royal Women's Hospital, Melbourne, Australia.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Davis
authors.affiliation: Newborn Research, Murdoch Children's Research Institute, Melbourne, Australia Department of Obstetrics, University of Melbourne, Melbourne, Australia Neonatal Research, Royal Women's Hospital, Melbourne, Australia.
authors.forename: Louise S
authors.initials: LS
authors.lastname: Owen
authors.affiliation: Newborn Research, Murdoch Children's Research Institute, Melbourne, Australia Neonatal Research, Royal Women's Hospital, Melbourne, Australia Department of Neonatology, Royal Children's Hospital, Melbourne, Australia Department of Paediatrics, University of Melbourne, Melbourne, Australia.
authors.forename: David G
authors.initials: DG
authors.lastname: Tingay
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000517:prevention & control; D003696:Delivery Rooms; D006801:Humans; D007231:Infant, Newborn; D055370:Lung Injury / Q000209:etiology; D036801:Parturition; D011175:Positive-Pressure Respiration; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D012151:Resuscitation / Q000009:adverse effects / Q000379:methods*
chemical_list: D011663:Pulmonary Surfactants
keywords: Neonatology; Respiratory; Resuscitation