title: The diagnostic accuracy of CT-guided percutaneous core needle biopsy and fine needle aspiration in pulmonary lesions: a meta-analysis.
abstract: OBJECTIVE
  To determine and compare the diagnostic value of computed tomography (CT)-guided percutaneous core needle biopsy (PCNB) and percutaneous fine-needle aspiration biopsy (PNAB) in pulmonary lesions.
  
  
  METHODS
  PubMed, EMBASE, and the Web of Science were systematically searched for relevant studies that investigated the diagnostic accuracy of CT-guided PCNB and/or PNAB for pulmonary lesions up to December 2014. After study selection, data extraction, and quality assessment, the sensitivity (SEN), specificity (SPE), diagnostic odds rate (DOR), positive likelihood ratios (PLR), negative likelihood ratios (NLR), and summary receiver operating characteristic (SROC) curves were calculated using the Meta-Disc 1.4 software.
  
  
  RESULTS
  Nineteen publications, including 21 independent studies, met the inclusion criteria. Of them, 15 studies were included in the PCNB group and six studies in the PNAB group. The pooled SEN, SPE, DOR, PLR, NLR, and SROC were 0.95, 0.99, 54.72, 0.06, 821.90, and 0.98 in the PCNB group and 0.90, 0.99, 24.71, 0.14, 210.72, and 0.98 in the PNAB group, respectively.
  
  
  CONCLUSIONS
  Based on current evidence, both PCNB and PNAB can be used as diagnostic methods to distinguish benign and malignant pulmonary lesions; the difference between PCNB and PNAB regarding diagnostic accuracy of benign or malignant pulmonary lesions is not obvious.
authors.affiliation: Department of Radiology, ZhongNan Hospital of WuHan University, No. 169 Donghu Road, Wuchang District, Wuhan City, Hubei Province, 430071, China.
authors.forename: H-F
authors.initials: HF
authors.lastname: Zhang
authors.affiliation: Department of Evidence-based Medicine Center, ZhongNan Hospital of WuHan University, No. 169 Donghu Road, Wuchang District, Wuhan City, Hubei Province, 430071, China.
authors.forename: X-T
authors.initials: XT
authors.lastname: Zeng
authors.affiliation: Department of Radiology, ZhongNan Hospital of WuHan University, No. 169 Donghu Road, Wuchang District, Wuhan City, Hubei Province, 430071, China.
authors.forename: F
authors.initials: F
authors.lastname: Xing
authors.affiliation: Department of Radiology, ZhongNan Hospital of WuHan University, No. 169 Donghu Road, Wuchang District, Wuhan City, Hubei Province, 430071, China.
authors.forename: N
authors.initials: N
authors.lastname: Fan
authors.affiliation: Department of Radiology, ZhongNan Hospital of WuHan University, No. 169 Donghu Road, Wuchang District, Wuhan City, Hubei Province, 430071, China. Electronic address: liaomy@whu.edu.cn.
authors.forename: M-Y
authors.initials: MY
authors.lastname: Liao
mesh_terms: D044963:Biopsy, Fine-Needle; D062005:Biopsy, Large-Core Needle; D003937:Diagnosis, Differential; D006801:Humans; D061705:Image-Guided Biopsy; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*