title: Risk of second primary breast cancer after radioactive iodine treatment in thyroid cancer: a systematic review and meta-analysis.
abstract: The aim of this study was to determine whether the risk of second primary breast cancer (SPBC) is increased in thyroid cancer patients treated with radioactive iodine (RAI). We searched the MEDLINE, EMBASE, and the Cochrane Library and Chinese database for studies that reported the risk of SPBC in thyroid cancer patients treated with RAI and patients not treated with RAI. Two independent reviewers screened citations and reviewed full-text papers. A meta-analysis was carried out using the Review Manager software. Six cohort studies (three from Europe, one from America, and two from east Asia) with 17,914 patients were included in this review. The relative risk of SPBC in thyroid cancer survivors treated with RAI was 0.61 (95% confidence interval 0.47-0.79) relative to thyroid cancer survivors not treated with RAI. The risk of SPBC in thyroid cancer survivors treated with RAI is not increased compared with thyroid cancer survivors not treated with RAI.
authors.affiliation: aDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Beijing bDepartment of Oncology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Cong
authors.forename: Yansong
authors.initials: Y
authors.lastname: Lin
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D012306:Risk; D013964:Thyroid Neoplasms / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes