title: Incidence of fetal bradycardia and effect of placental injury on fetal heart rate during second-trimester genetic amniocentesis.
abstract: A prospective study was conducted for comparing the incidence of fetal bradycardia and level of fetal heart rate change following a second-trimester genetic amniocentesis with and without placental injury. A total of 257 and 495 participants in injured and non-injured groups were analysed. The incidence of fetal bradycardia following amniocentesis was not statistically different between the two groups (1.17%, [95% CI 0.24, 3.37] and 0.20%, [95% CI 0.005, 1.12]) in injured and non-injured placenta groups, respectively; p = 0.118). The mean change in baseline fetal heart rate before and after amniocentesis was also not significantly different between the two groups (p = 0.844). No fetal death or pregnancy loss occurred within 4 weeks after the procedure. All 4 bradycardia participants were normal and healthy and had an appropriate weight for their gestational age. We conclude that placental injury during a second-trimester genetic amniocentesis due to advanced maternal age poses only a low risk of fetal bradycardia, and there is no evidence of differences between subjects with injured and non-injured placenta in the changes in fetal heart rate.
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Prince of Songkla University , Hatyai, Songkhla , Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Hanprasertpong
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Prince of Songkla University , Hatyai, Songkhla , Thailand.
authors.forename: C
authors.initials: C
authors.lastname: Petpichetchian
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Prince of Songkla University , Hatyai, Songkhla , Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Ponglopisit
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Prince of Songkla University , Hatyai, Songkhla , Thailand.
authors.forename: M
authors.initials: M
authors.lastname: Suksai
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Prince of Songkla University , Hatyai, Songkhla , Thailand.
authors.forename: O
authors.initials: O
authors.lastname: Kor-Anantakul
authors.affiliation: b Epidemiology Unit, Faculty of Medicine, Prince of Songkla University , Hatyai, Songkhla , Thailand.
authors.forename: A
authors.initials: A
authors.lastname: Geater
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Prince of Songkla University , Hatyai, Songkhla , Thailand.
authors.forename: N
authors.initials: N
authors.lastname: Pruksanusak
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Prince of Songkla University , Hatyai, Songkhla , Thailand.
authors.forename: J
authors.initials: J
authors.lastname: Hanprasertpong
mesh_terms: D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects*; D001919:Bradycardia / Q000196:embryology / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology* / Q000209:etiology; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006801:Humans; D015994:Incidence; D008423:Maternal Age; D010920:Placenta / Q000293:injuries*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012307:Risk Factors
keywords: Amniocentesis; bradycardia; fetal heart rate; placenta injury