title: Enhancement of TFO Triplex Formation by Conjugation with Pyrene via Click Chemistry.
abstract: This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-O-methyl-1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Akira
authors.initials: A
authors.lastname: Tomizaki
authors.forename: Nozomu
authors.initials: N
authors.lastname: Matsueda
authors.forename: Hidenori
authors.initials: H
authors.lastname: Okamura
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001483:Base Sequence; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D057930:Click Chemistry; D004247:DNA / Q000737:chemistry*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011721:Pyrenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009841:Oligonucleotides; D011721:Pyrenes; C051802:triplex DNA; D004247:DNA; C030984:pyrene