title: [A comparison of the efficacy and safety of memantal and original memantine in the treatment of mild and moderate dementia in Alzheimer's disease].
abstract: OBJECTIVE
  To estimate the efficacy and safety of original memantine and generic medication (memantal) in patients with mild/ moderate dementia due to Alzheimer's disease (AD).
  
  
  METHODS
  A six-month randomized controlled comparative study included 50 patients with mild/moderate dementia due to AD. Patients were naive to memantine and IAChe. Original memantine and generic medication dosage (5 mg daily) was titrated according to the manufacturer's recommendations. Patient's condition was assessed with MMSE, the Neuropsychiatric Inventory (NPI) and IADL. Side-effects were recorded.
  
  
  RESULTS
  There were no statistically significant differences in cognitive functions, neuropsychiatric symptoms, instrumental activity and safety between original memantine and generic medication. Both medications slightly improved patient's cognitive functioning, mostly in patients with mild dementia due to senile type of AD.
  
  
  CONCLUSIONS
  The generic medication (memantal) and original memantine have equal efficacy and safety in patients with mild/moderate dementia due to AD.
authors.affiliation: Voronezh Regional Clinical Psychoneurological Dispensary, Voronezh.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Shiryaev
authors.affiliation: Voronezh Regional Clinical Psychoneurological Dispensary, Voronezh.
authors.forename: D L
authors.initials: DL
authors.lastname: Shapovalov
authors.affiliation: Voronezh Regional Clinical Psychoneurological Dispensary, Voronezh.
authors.forename: T M
authors.initials: TM
authors.lastname: Polozova
authors.affiliation: Voronezh Regional Clinical Psychoneurological Dispensary, Voronezh.
authors.forename: O V
authors.initials: OV
authors.lastname: Goncharova
authors.affiliation: Voronezh Regional Clinical Psychoneurological Dispensary, Voronezh.
authors.forename: N A
authors.initials: NA
authors.lastname: Kuznetsova
authors.affiliation: Voronezh Regional Clinical Psychoneurological Dispensary, Voronezh.
authors.forename: E V
authors.initials: EV
authors.lastname: Cherenkova
authors.affiliation: Voronezh Regional Clinical Psychoneurological Dispensary, Voronezh.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Fedorova
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D003071:Cognition / Q000187:drug effects; D016568:Drugs, Generic / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008559:Memantine / Q000494:pharmacology / Q000627:therapeutic use*; D010555:Personality Inventory
chemical_list: D016568:Drugs, Generic; D008559:Memantine