title: Two new triterpenoids from Gypsophila oldhamiana.
abstract: Two new triterpenoids (1-2) were isolated and elucidated from the roots of Gypsophila oldhamiana, together with four known triterpenoids (3-6). Their structures were identified to be 3β-hydroxyolean-13(18)-ene-23, 28-dioic acid (1), 3β, 12α-dihydroxy-23-carboxyolean-28, 13β-olide (2), 3β, 16α-dihydroxy-23-oxoolean-13(18)-en-28-oic acid (3), gypsogenin (4), quillaic acid (5) and gypsogenic acid (6) by spectral methods. All compounds were tested for their cytotoxicities against human tumour cell lines (lung cancer H460 and gastric cancer SGC-7901) and for their antiangiogenic effects using a zebra fish model. All compounds showed interesting antiangiogenic activities and the significant cytotoxicities against H460.
authors.affiliation: a Institute of Materia Medica, Shandong Academy of Medical Sciences , Jinan , P.R. China.|b School of Medicine and Life Sciences, Shandong Academy of Medical Sciences , University of Jinan , Jinan , P.R. China.|c Key Laboratory of Rare and Uncommon Diseases of Shandong Province , Shandong Academy of Medical Sciences , Jinan , P.R. China.
authors.forename: Long-Xiao
authors.initials: LX
authors.lastname: Xie
authors.affiliation: a Institute of Materia Medica, Shandong Academy of Medical Sciences , Jinan , P.R. China.|b School of Medicine and Life Sciences, Shandong Academy of Medical Sciences , University of Jinan , Jinan , P.R. China.|c Key Laboratory of Rare and Uncommon Diseases of Shandong Province , Shandong Academy of Medical Sciences , Jinan , P.R. China.
authors.forename: Hao-Chao
authors.initials: HC
authors.lastname: Zhang
authors.affiliation: a Institute of Materia Medica, Shandong Academy of Medical Sciences , Jinan , P.R. China.|c Key Laboratory of Rare and Uncommon Diseases of Shandong Province , Shandong Academy of Medical Sciences , Jinan , P.R. China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Wang
authors.affiliation: a Institute of Materia Medica, Shandong Academy of Medical Sciences , Jinan , P.R. China.|c Key Laboratory of Rare and Uncommon Diseases of Shandong Province , Shandong Academy of Medical Sciences , Jinan , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Institute of Materia Medica, Shandong Academy of Medical Sciences , Jinan , P.R. China.|c Key Laboratory of Rare and Uncommon Diseases of Shandong Province , Shandong Academy of Medical Sciences , Jinan , P.R. China.
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Wang
authors.affiliation: a Institute of Materia Medica, Shandong Academy of Medical Sciences , Jinan , P.R. China.|c Key Laboratory of Rare and Uncommon Diseases of Shandong Province , Shandong Academy of Medical Sciences , Jinan , P.R. China.
authors.forename: Jing-Yong
authors.initials: JY
authors.lastname: Sun
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D029748:Caryophyllaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004625:Embryo, Nonmammalian; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000031:analogs & derivatives; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000032:analysis*; D015027:Zebrafish
chemical_list: C000611820:3beta,12alpha-dihydroxy-23-carboxyolean-28,13beta-olide; C000611801:3beta-hydroxyolean-13(18)-ene-23,28-dioic acid; D020533:Angiogenesis Inhibitors; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes; D009828:Oleanolic Acid
keywords: Gypsophila oldhamiana; antiangiogenic effect; cytotoxic activity; triterpenoid