title: Clinical Impact of β-Lactamase-producing Enterobacteriaceae in Sputum of Cystic Fibrosis Patients.
abstract: This case series describes 18 cystic fibrosis (CF) patients of a 135-patient CF center cohort with extended spectrum β-lactamase-producing Enterobacteriaceae, from 2003 to 2012. Four had chronic infection. Prevalence increased annually from 0 to 6.35%. Risk factors compared with the 2010 CF center cohort included continuous inhaled antibiotics (P = 0.014) and courses of intravenous antibiotics during the year before first isolation (P = 0.009). Hospitalization rates were 1.05/year and 0.47/year preinfection and postinfection, respectively (P = 0.02). Slope of forced expiratory volume at 1 second% predicted remained unchanged during 12 months.
authors.affiliation: From the *Graub CF Center, Pulmonary Institute, Schneider Children's Medical Center of Israel, Petah Tikva, Israel; †Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel; ‡Clalit Health Services, Sharon Shomron District, Israel; §Microbiology Laboratory, Rabin Medical Center, Petach Tikva, Israel; ¶Pediatrics A Department, and ‖Infectious Diseases Unit, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
authors.forename: Huda
authors.initials: H
authors.lastname: Mussaffi
authors.forename: Naama Fisch
authors.initials: NF
authors.lastname: Shvalb
authors.forename: Haim
authors.initials: H
authors.lastname: Ben-Zvi
authors.forename: Gilat
authors.initials: G
authors.lastname: Livni
authors.forename: Meir
authors.initials: M
authors.lastname: Mei-Zahav
authors.forename: Dario
authors.initials: D
authors.lastname: Prais
authors.forename: Patrick
authors.initials: P
authors.lastname: Stafler
authors.forename: Guy
authors.initials: G
authors.lastname: Steuer
authors.forename: Hannah
authors.initials: H
authors.lastname: Blau
mesh_terms: D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology*; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013183:Sputum / Q000382:microbiology*; D055815:Young Adult; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases