title: CEACAM1-4L Promotes Anchorage-Independent Growth in Melanoma.
abstract: Widespread metastasis is the leading course of death in many types of cancer, including malignant melanoma. The process of metastasis can be divided into a number of complex cell biological events, collectively termed the "invasion-metastasis cascade." Previous reports have characterized the capability of anchorage-independent growth of cancer cells in vitro as a key characteristic of highly aggressive tumor cells, particularly with respect to metastatic potential. Biological heterogeneity as well as drastic alterations in cell adhesion of disseminated cancer cells support escape mechanisms for metastases to overcome conventional therapies. Here, we show that exclusively the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) splice variant CEACAM1-4L supports an anchorage-independent signature in malignant melanoma. These results highlight important variant-specific modulatory functions of CEACAM1 for metastatic spread in patients suffering malignant melanoma.
authors.affiliation: Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University of Duisburg-Essen , Essen , Germany ; German Cancer Consortium (DKTK), Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Löffek
authors.affiliation: Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University of Duisburg-Essen , Essen , Germany ; German Cancer Consortium (DKTK), Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: Nico
authors.initials: N
authors.lastname: Ullrich
authors.affiliation: Institute for Transfusion Medicine, Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: André
authors.initials: A
authors.lastname: Görgens
authors.affiliation: Institute for Transfusion Medicine, Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Murke
authors.affiliation: Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University of Duisburg-Essen , Essen , Germany ; German Cancer Consortium (DKTK), Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: Mara
authors.initials: M
authors.lastname: Eilebrecht
authors.affiliation: Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University of Duisburg-Essen , Essen , Germany ; German Cancer Consortium (DKTK), Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Menne
authors.affiliation: Institute for Transfusion Medicine, Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Giebel
authors.affiliation: Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University of Duisburg-Essen , Essen , Germany ; German Cancer Consortium (DKTK), Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Schadendorf
authors.affiliation: Institute of Anatomy, Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: Bernhard B
authors.initials: BB
authors.lastname: Singer
authors.affiliation: Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University of Duisburg-Essen , Essen , Germany ; German Cancer Consortium (DKTK), Medical Faculty, University of Duisburg-Essen , Essen , Germany.
authors.forename: Iris
authors.initials: I
authors.lastname: Helfrich
keywords: CEACAM1; anchorage-independent cell growth; heterogeneity; melanoma; metastatic potential