title: Sleep-dependent memory consolidation and its implications for psychiatry.
abstract: Both sleep disturbance and memory impairment are very common in psychiatric disorders. Since sleep has been shown to play a role in the process of transferring newly acquired information into long-term memory, i.e., consolidation, it is important to highlight this link in the context of psychiatric disorders. Along these lines, after providing a brief overview of healthy human sleep, current neurobiological models on sleep-dependent memory consolidation and resultant opportunities to manipulate the memory consolidation process, recent findings on sleep disturbances and sleep-dependent memory consolidation in patients with insomnia, major depression, schizophrenia, and post-traumatic stress disorder are systematically reviewed. Furthermore, possible underlying neuropathologies and their implications on therapeutic strategies are discussed. This review aims at sensitizing the reader for recognizing sleep disturbances as a potential contributor to cognitive deficits in several disorders, a fact which is often overlooked up to date.
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany. monique.goerke@med.uni-rostock.de.|Department of Psychiatry and Psychotherapy, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany. monique.goerke@med.uni-rostock.de.
authors.forename: Monique
authors.initials: M
authors.lastname: Goerke
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
authors.forename: Notger G
authors.initials: NG
authors.lastname: Müller
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Cohrs
mesh_terms: D000818:Animals; D006801:Humans; D000069077:Memory Consolidation / Q000502:physiology*; D001523:Mental Disorders / Q000503:physiopathology* / Q000628:therapy; D011570:Psychiatry; D012890:Sleep / Q000502:physiology*
keywords: Insomnia; Major depression; Memory consolidation; Post-traumatic stress disorder; Schizophrenia; Sleep