title: Symmetric Meso-Chloro-Substituted Pentamethine Cyanine Dyes Containing Benzothiazolyl/Benzoselenazolyl Chromophores Novel Synthetic Approach and Studies on Photophysical Properties upon Interaction with bio-Objects.
abstract: A series of symmetric pentamethine cyanine dyes derived from various N-substituted benzothiazolium/benzoselenazolium salts, and a conjugated bis-aniline derivative containing a chlorine atom at meso-position with respect to the polymethine chain, were synthesized using a novel improved synthetic approach under mild conditions at room temperature. The reaction procedure was held by grinding the starting compounds for relative short times. The novel method is reliable and highly reproducible. Some photophysical characteristics were recorded in various solvents, including absorption, and fluorescence quantum yields using Cy-5 as a reference. Additional studies on interactions with several bio-objects such as liposomes, DNA, and proteins have been investigated in the present work.
authors.affiliation: Sofia University "St. Kliment Ohridski", Faculty of Chemistry and Pharmacy, 1, blv. J. Bourchier, 1164, Sofia, Bulgaria. ohtak@chem.uni-sofia.bg.
authors.forename: Atanas
authors.initials: A
authors.lastname: Kurutos
authors.affiliation: Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61077, Ukraine.
authors.forename: Olga
authors.initials: O
authors.lastname: Ryzhova
authors.affiliation: Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61077, Ukraine. valtrusova@yahoo.com.|19-32 Geroyev Truda, Kharkiv, 61044, Ukraine. valtrusova@yahoo.com.
authors.forename: Valeriya
authors.initials: V
authors.lastname: Trusova
authors.affiliation: Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61077, Ukraine.
authors.forename: Galyna
authors.initials: G
authors.lastname: Gorbenko
authors.affiliation: Sofia University "St. Kliment Ohridski", Faculty of Chemistry and Pharmacy, 1, blv. J. Bourchier, 1164, Sofia, Bulgaria.
authors.forename: Nikolay
authors.initials: N
authors.lastname: Gadjev
authors.affiliation: Sofia University "St. Kliment Ohridski", Faculty of Chemistry and Pharmacy, 1, blv. J. Bourchier, 1164, Sofia, Bulgaria.
authors.forename: Todor
authors.initials: T
authors.lastname: Deligeorgiev
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry*; D002232:Carbocyanines / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000737:chemistry*; D055668:Photochemical Processes; D011506:Proteins / Q000737:chemistry*; D013696:Temperature
chemical_list: D052160:Benzothiazoles; D002232:Carbocyanines; D005456:Fluorescent Dyes; D008081:Liposomes; D016566:Organoselenium Compounds; D011506:Proteins; D004247:DNA
keywords: 2-methylbenzoselenazole; 2-methylbenzothiazole; DNA, proteins; Fluorescent markers; H-aggregates; Liposomes; Pentamethine cyanine dyes