title: miRNAs: biological and clinical determinants in epilepsy.
abstract: Recently, microRNAs (miRNAs) are reported to be crucial modulators in the pathogenesis and potential treatment of epilepsies. To date, several miRNAs have been demonstrated to be significantly expressed in the epileptic tissues and strongly associated with the development of epilepsy. Specifically, miRNAs regulate synaptic strength, inflammation, neuronal and glial function, ion channels, and apoptosis. Furthermore, peripheral blood miRNAs can also be utilized as diagnostic biomarkers to assess disease risk and treatment responses. Here, we will summarize the recent available literature regarding the role of miRNAs in the pathogenesis and treatment of epilepsy. Moreover, we will provide brief insight into the potential of miRNA as diagnostic biomarkers for early diagnosis and prognosis of epilepsy.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Walid A
authors.initials: WA
authors.lastname: Alsharafi
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
authors.affiliation: Department of Neurology, Alkhadamat Altebia Hospital Amman, Jordan.
authors.forename: Mutasem M
authors.initials: MM
authors.lastname: Abuhamed
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Luo
keywords: biomarkers; epilepsy; hippocampus; miRNA; pathogenesis