title: Effects of Nanoparticle Morphology and Acyl Chain Length on Spontaneous Lipid Transfer Rates.
abstract: We report on studies of lipid transfer rates between different morphology nanoparticles and lipids with different length acyl chains. The lipid transfer rate of dimyristoylphosphatidylcholine (di-C14, DMPC) in discoidal "bicelles" (0.156 h(-1)) is 2 orders of magnitude greater than that of DMPC vesicles (ULVs) (1.1 × 10(-3) h(-1)). For both bicellar and ULV morphologies, increasing the acyl chain length by two carbons [going from di-C14 DMPC to di-C16, dipalmitoylphosphatidylcholine (DPPC)] causes lipid transfer rates to decrease by more than 2 orders of magnitude. Results from small angle neutron scattering (SANS), differential scanning calorimetry (DSC), and fluorescence correlation spectroscopy (FCS) are in good agreement. The present studies highlight the importance of lipid dynamic processes taking place in different morphology biomimetic membranes.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Connecticut , Storrs, Connecticut 06269, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Polymer Program, Institute of Materials Science, University of Connecticut , Storrs, Connecticut 06269, United States.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Connecticut , Storrs, Connecticut 06269, United States.
authors.forename: Kamil
authors.initials: K
authors.lastname: Charubin
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Connecticut , Storrs, Connecticut 06269, United States.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831 United States.|Joint Institute for Neutron Sciences, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Heberle
authors.affiliation: Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831 United States.|Department of Physics and Astronomy, University of Tennessee , Knoxville, Tennessee 37996, United States.|Joint Institute for Neutron Sciences, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.
authors.forename: John
authors.initials: J
authors.lastname: Katsaras
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Notre Dame , Notre Dame, Indiana 46556, United States.
authors.forename: Benxin
authors.initials: B
authors.lastname: Jing
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Notre Dame , Notre Dame, Indiana 46556, United States.|Department of Chemical Engineering and Materials Science, Wayne State University , Detroit, Michigan 48202 United States.
authors.forename: Yingxi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Connecticut , Storrs, Connecticut 06269, United States.|Polymer Program, Institute of Materials Science, University of Connecticut , Storrs, Connecticut 06269, United States.|Department of Biomedical Engineering, University of Connecticut , Storrs, Connecticut 06269, United States.
authors.forename: Mu-Ping
authors.initials: MP
authors.lastname: Nieh
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D015060:1,2-Dipalmitoylphosphatidylcholine; D004134:Dimyristoylphosphatidylcholine