title: Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso.
abstract: We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped. Single nucleotide polymorphism in Pfcrt (codon 76) gene was analyzed. The prevalence of resistant Pfcrt 76T allele was 20.55%. There was a progressive decrease of the proportion of mutant type pfcrt T76 from 2010 to 2012 (X2=5.508 p=0.0189). Our results suggest a progressive return of the wild type Pfcrt K76 in Burkina Faso but the prevalence of the mutants Pfcrt T76 still remains high.
authors.affiliation: IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso.
authors.forename: Paul
authors.initials: P
authors.lastname: Sondo
authors.affiliation: IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso.
authors.forename: Karim
authors.initials: K
authors.lastname: Derra
authors.affiliation: IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso.
authors.forename: Zekiba
authors.initials: Z
authors.lastname: Tarnagda
authors.affiliation: IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso.
authors.forename: Seydou Diallo
authors.initials: SD
authors.lastname: Nakanabo
authors.affiliation: Center Muraz of Bobo-Dioulasso, Burkina Faso.
authors.forename: Odile
authors.initials: O
authors.lastname: Zampa
authors.affiliation: IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso.
authors.forename: Adama
authors.initials: A
authors.lastname: Kazienga
authors.affiliation: IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso ; Center Muraz of Bobo-Dioulasso, Burkina Faso.
authors.forename: Innocent
authors.initials: I
authors.lastname: Valea
authors.affiliation: IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso.
authors.forename: Hermann
authors.initials: H
authors.lastname: Sorgho
authors.affiliation: IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso.
authors.forename: Jean-Bosco
authors.initials: JB
authors.lastname: Ouedraogo
authors.affiliation: Center Muraz of Bobo-Dioulasso, Burkina Faso.
authors.forename: Tinga Robert
authors.initials: TR
authors.lastname: Guiguemde
authors.affiliation: IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso ; Center Muraz of Bobo-Dioulasso, Burkina Faso.
authors.forename: Halidou
authors.initials: H
authors.lastname: Tinto
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D002050:Burkina Faso / Q000453:epidemiology; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D026901:Membrane Transport Proteins / Q000235:genetics*; D009154:Mutation; D010963:Plasmodium falciparum / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D015800:Protozoan Proteins / Q000235:genetics*
chemical_list: D000962:Antimalarials; D026901:Membrane Transport Proteins; C416369:PfCRT protein, Plasmodium falciparum; D015800:Protozoan Proteins; D002738:Chloroquine
keywords: Malaria; chloroquine resistance; pfcrt; plasmodium falciparum