title: Association Between Circulating Osteogenic Progenitor Cells and Disability and Frailty in Older Persons: The Nepean Osteoporosis and Frailty Study.
abstract: Circulating osteogenic progenitor (COP) cells are considered as surrogates of the mesenchymal repository in the body. In this study, we hypothesized that COP cells decrease with age and that lower levels of COP cells are associated with greater frailty and disability in older persons. Using well-established clinical criteria, we quantified physical performance and disability and stratified frailty in a random sample of community-dwelling individuals enrolled in the Nepean Osteoporosis and Frailty (NOF) Study (mean age 82.8; N = 77; 70% female; 27 nonfrail, 23 prefrail, and 27 frail). Percentage of COP cells was quantified by flow cytometry. Logistic regression models estimated the relationship between the percentage of COP cells and prevalent disability, poor physical performance, and frailty. We found that aging is associated with a significant decrease in COP cells (p < .001). Lower percentages of COP cells were associated with disability and poor physical performance (p < .001). Older adults with COP cells in the lower quartile were more likely to be frail (odds ratio 2.65, 95% confidence interval 2.72-3.15, p < .001). In conclusion, COP cells in the circulation decrease with age. Lower percentages of COP cells in late life are associated with prevalent frailty and disability. Further longitudinal studies are needed to understand COP cells as a risk stratifier, biomarker, or therapeutic target and to predict disability in frail older persons.
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia. Department of Geriatric Medicine, Nepean Hospital, Penrith, New South Wales, Australia.
authors.forename: Piumali
authors.initials: P
authors.lastname: Gunawardene
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Bermeo
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia.
authors.forename: Christopher
authors.initials: C
authors.lastname: Vidal
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Saedi
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia.
authors.forename: Philip
authors.initials: P
authors.lastname: Chung
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia. Department of Geriatric Medicine, Nepean Hospital, Penrith, New South Wales, Australia.
authors.forename: Derek
authors.initials: D
authors.lastname: Boersma
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia.
authors.forename: Steven
authors.initials: S
authors.lastname: Phu
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia.
authors.forename: Izabella
authors.initials: I
authors.lastname: Pokorski
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia.
authors.forename: Pushpa
authors.initials: P
authors.lastname: Suriyaarachchi
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia. Department of Geriatric Medicine, Nepean Hospital, Penrith, New South Wales, Australia.
authors.forename: Oddom
authors.initials: O
authors.lastname: Demontiero
authors.affiliation: Musculoskeletal Ageing Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia. Department of Geriatric Medicine, Nepean Hospital, Penrith, New South Wales, Australia. gustavo.duque@sydney.edu.au.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Duque
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001315:Australia / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data; D015577:Geriatric Assessment; D006801:Humans; D057187:Independent Living; D008297:Male; D010006:Osteoblasts / Q000378:metabolism; D010024:Osteoporosis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D011237:Predictive Value of Tests; D015995:Prevalence; D055948:Sarcopenia / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: Disability; Frailty; Human aging; Stem cells