title: Detection of Leptomeningeal Involvement by 18F-FDG-PET/CT in a Patient With Non-Hodgkin Lymphoma.
abstract: Leptomeningeal infiltration of the brain or spinal cord by neoplastic cells may occur as complication of solid or hematopoietic tumors such as non-Hodgkin lymphoma. Previously rare, this event is becoming increasingly common as newer therapies can prolong survival but may not achieve therapeutic concentration in the central nervous system. Although prognosis is poor, early diagnosis and aggressive treatment may lead to prolonged survival and/or improvement of quality of life. We report a case of a 69-year-old man with leptomeningeal infiltration by non-Hodgkin lymphoma revealed by F-FDG-PET/CT and confirmed by subsequent spinal MRI and cerebrospinal fluid cytology.
authors.affiliation: From the *Institute of Biostructures and Bioimages, National Research Council; †Department of Hematology, University "Federico II"; ‡IRCCS-SDN; and §Department of Advanced Biomedical Sciences, University "Federico II," Naples, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Fonti
authors.forename: Barbara
authors.initials: B
authors.lastname: Salvatore
authors.forename: Amalia
authors.initials: A
authors.lastname: De Renzo
authors.forename: Emanuele
authors.initials: E
authors.lastname: Nicolai
authors.forename: Silvana
authors.initials: S
authors.lastname: Del Vecchio
mesh_terms: D000368:Aged; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18