title: Fragile Nucleosomes Influence Pol II Promoter Function.
abstract: In this issue of Molecular Cell, Kubik et al. (2015) describe how the RSC chromatin remodeling complex collaborates with two DNA sequence motifs and sequence-specific general regulatory factors to assemble fragile nucleosomes at highly transcribed yeast Pol II promoters, and they distinguish these from promoters bearing stable nucleosomes.
authors.affiliation: Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Suman K
authors.initials: SK
authors.lastname: Pradhan
authors.affiliation: Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: mcarey@mednet.ucla.edu.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Carey
mesh_terms: D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D009707:Nucleosomes / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000096:biosynthesis*
chemical_list: D009707:Nucleosomes; D029701:Saccharomyces cerevisiae Proteins