title: A Family History of Sudden Death Should Not Be a Primary Indication for an Implantable Cardioverter Defibrillator in Hypertrophic Cardiomyopathy.
abstract: Sudden cardiac death (SCD) is a tragic outcome in hypertrophic cardiomyopathy, but it occurs at a low frequency overall and is challenging to predict accurately. Many important predictors of SCD have emerged over the past 50 years, one of which is a family history of SCD. The available data are limited by their retrospective nature and variability in the definition of family history across studies. We advocate a novel model of risk stratification in which no individual predictor has primacy; rather the overall clinical picture of the patient is used to determine their SCD risk.
authors.affiliation: Inherited Cardiovascular Disease, St Bartholomew's Hospital, West Smithfield, London, United Kingdom.
authors.forename: Oliver T
authors.initials: OT
authors.lastname: Watkinson
authors.affiliation: Inherited Cardiovascular Disease, St Bartholomew's Hospital, West Smithfield, London, United Kingdom. Electronic address: perry.elliott@ucl.ac.uk.
authors.forename: Perry M
authors.initials: PM
authors.lastname: Elliott
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000235:genetics / Q000628:therapy; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000209:etiology*; D017147:Defibrillators, Implantable; D014943:Global Health; D006801:Humans; D015994:Incidence; D018570:Risk Assessment; D012307:Risk Factors