title: Epidermal barrier in hereditary ichthyoses, atopic dermatitis, and psoriasis.
abstract: Several skin disorders are associated with impaired skin barrier function. Primary dysfunction is caused by monogenic defects in key components of the epidermis (for example ichthyoses). Secondary barrier impairment occurs in inflammatory dermatoses marked by disturbed epidermal homeostasis (eczema, psoriasis, etc.). In these disorders, inflammation impedes the synthesis or maintenance of skin barrier components. Recent evidence suggests a combination of primary and secondary barrier dysfunction in atopic dermatitis and, to a lesser extent, also in psoriasis. In the future, subtypes of atopic dermatitis may likely be defined, in which one or the other is prevalent.
authors.affiliation: Department of Dermatology and Venereology, University of Innsbruck, Innsbruck, Austria.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schmuth
authors.affiliation: Department of Dermatology and Venereology, University of Innsbruck, Innsbruck, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Blunder
authors.affiliation: Department of Dermatology and Venereology, University of Innsbruck, Innsbruck, Austria.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Dubrac
authors.affiliation: Department of Dermatology and Venereology, University of Innsbruck, Innsbruck, Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Gruber
authors.affiliation: Department of Dermatology and Venereology, University of Innsbruck, Innsbruck, Austria.
authors.forename: Verena
authors.initials: V
authors.lastname: Moosbrugger-Martinz
mesh_terms: D003876:Dermatitis, Atopic / Q000503:physiopathology*; D006801:Humans; D007057:Ichthyosis / Q000503:physiopathology*; D008954:Models, Biological; D009154:Mutation / Q000235:genetics*; D011565:Psoriasis / Q000503:physiopathology*; D012867:Skin / Q000503:physiopathology*; D012869:Skin Absorption