title: Sulfate Radical Anion (SO4(•-)) Mediated C(sp(3))-H Nitrogenation/Oxygenation in N-Aryl Benzylic Amines Expanded the Scope for the Synthesis of Benzamidine/Oxazine Heterocycles.
abstract: A transition-metal-free, K2S2O8-mediated intramolecular oxidative nitrogenation/oxygenation of C(sp(3))-H in N-aryl benzylic amines followed by oxidation at the benzylic center has been developed for the synthesis of benzamidine/benzoxazine heterocycles, providing an expedient access to quinazolin-4(3H)-ones, N-aryl-2-arylbenzimidazoles, and 4H-3,1-benzoxazin-4-ones. A considerable amount of work dealing with the mechanistic study to understand the crucial intramolecular cyclization step largely favors an iminium ion as the key intermediate.
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry) National Institute of Pharmaceutical Education and Research S. A. S. Nagar, Punjab 160062 India.
authors.forename: Joydev K
authors.initials: JK
authors.lastname: Laha
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry) National Institute of Pharmaceutical Education and Research S. A. S. Nagar, Punjab 160062 India.
authors.forename: K S Satyanarayana
authors.initials: KS
authors.lastname: Tummalapalli
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry) National Institute of Pharmaceutical Education and Research S. A. S. Nagar, Punjab 160062 India.
authors.forename: Akshay
authors.initials: A
authors.lastname: Nair
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry) National Institute of Pharmaceutical Education and Research S. A. S. Nagar, Punjab 160062 India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Patel