title: The feeding responses evoked by endogenous cholecystokinin are regulated by different gastrointestinal sites.
abstract: The current study tested the hypothesis that cholecystokinin (CCK) A receptor (CCKAR) in areas supplied by the celiac artery (CA), stomach and upper duodenum, and the cranial mesenteric artery (CMA), small and parts of the large intestine, is necessary for reduction of meal size, prolongation of the intermeal interval (time between first and second meal) and increased satiety ratio (intermeal interval/meal size or amount of food consumed during any given unit of time) by the non-nutrient stimulator of endogenous CCK release camostat. Consistent with our previous findings camostat reduced meal size, prolonged the intermeal interval and increased the satiety ratio. Here, we report that blocking CCKAR in the area supplied by the celiac artery attenuated reduction of meal size by camostat more so than the cranial mesenteric artery route. Blocking CCKAR in the area supplied by the cranial mesenteric artery attenuated prolongation of the intermeal interval length and increased satiety ratio by camostat more so than the celiac artery route. Blocking CCKAR in the areas supplied by the femoral artery (control) failed to alter the feeding responses evoked by camostat. These results support the hypothesis that CCKAR in the area supplied by the CA is necessary for reduction of meal size by camostat whereas CCKAR in the area supplied by the CMA is necessary for prolongation of the intermeal interval and increased satiety ratio by this substance. Our results demonstrate that meal size and intermeal interval length by camostat are regulated through different gastrointestinal sites.
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, United States.
authors.forename: Martha C
authors.initials: MC
authors.lastname: Washington
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, United States.
authors.forename: Kasey
authors.initials: K
authors.lastname: Williams
authors.affiliation: Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, United States. Electronic address: sayeghai@mytu.tuskegee.edu.
authors.forename: Ayman I
authors.initials: AI
authors.lastname: Sayegh
mesh_terms: D000818:Animals; D002445:Celiac Artery / Q000378:metabolism*; D002766:Cholecystokinin / Q000378:metabolism*; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D004952:Esters; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005263:Femoral Artery / Q000378:metabolism; D016670:Gabexate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006146:Guanidines; D008297:Male; D017538:Mesenteric Artery, Superior / Q000378:metabolism*; D011480:Protease Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D043886:Receptor, Cholecystokinin A / Q000378:metabolism*; D013997:Time Factors
chemical_list: D004952:Esters; D006146:Guanidines; D011480:Protease Inhibitors; D043886:Receptor, Cholecystokinin A; C034532:camostat; D016670:Gabexate; D002766:Cholecystokinin
keywords: CCK; Celiac artery; Cranial mesenteric artery; Femoral artery; Food intake