title: Relationship between renal function and renal volume in autosomal dominant polycystic kidney disease: cross-sectional study.
abstract: OBJECTIVE
  To determine in patients with autosomal dominant polycystic kidney disease the relationship between total renal volume (the sum of both kidneys, TRV) as measured by magnetic resonance and renal function; and its behaviour according to sex and the presence of arterial hypertension, hypercholesterolaemia and hyperglycemia.
  
  
  METHODS
  Cross-sectional study including patients with autosomal dominant polycystic kidney disease who underwent periodic reviews at Nephrology external consultations at Hospital de las Nieves de Granada, and who underwent an magnetic resonance to estimate renal volume between January 2008 and March 2011.
  
  
  RESULTS
  We evaluated 67 patients (59.7% women, average age of 48±14.4 years) and found a significant positive association between TRV and serum creatinine or urea, which was reversed compared with estimated glomerular filtration by MDRD-4 and Cockcroft-Gault. Women showed an average serum creatinine level and a significantly lower TRV level compared with males. Subgroups affected by arterial hypertension and hyperuricemia presented average values for serum creatinine and urea, higher for TRV and lower for estimated glomerular filtration. The hypercholesterolaemia subgroup showed higher average values for urea and lower for estimated glomerular filtration, without detecting significant differences compared with TRV.
  
  
  CONCLUSIONS
  The volume of polycystic kidneys measured by magnetic resonance is associated with renal function, and can be useful as a complementary study to monitor disease progression. The presence of arterial hypertension, hyperuricemia or hypercholesterolaemia is associated with a poorer renal function.
authors.affiliation: UGC de Nefrología, Complejo Hospitalario Universitario de Granada, Hospitales San Cecilio y Virgen de las Nieves y Atención Primaria de Granada, IBS, Granada, España. Electronic address: mjtosan@gmail.com.
authors.forename: M J
authors.initials: MJ
authors.lastname: Torres-Sánchez
authors.affiliation: UGC de Nefrología, Complejo Hospitalario Universitario de Granada, Hospitales San Cecilio y Virgen de las Nieves y Atención Primaria de Granada, IBS, Granada, España.
authors.forename: E
authors.initials: E
authors.lastname: Ávila-Barranco
authors.affiliation: UGC de Nefrología, Complejo Hospitalario Universitario de Granada, Hospitales San Cecilio y Virgen de las Nieves y Atención Primaria de Granada, IBS, Granada, España.
authors.forename: R J
authors.initials: RJ
authors.lastname: Esteban de la Rosa
authors.affiliation: UGC de Nefrología, Complejo Hospitalario Universitario de Granada, Hospitales San Cecilio y Virgen de las Nieves y Atención Primaria de Granada, IBS, Granada, España.
authors.forename: R
authors.initials: R
authors.lastname: Fernández-Castillo
authors.affiliation: UGC de Nefrología, Complejo Hospitalario Universitario de Granada, Hospitales San Cecilio y Virgen de las Nieves y Atención Primaria de Granada, IBS, Granada, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Esteban
authors.affiliation: Center for Gender Medicine and Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: J J
authors.initials: JJ
authors.lastname: Carrero
authors.affiliation: UGC de Nefrología, Complejo Hospitalario Universitario de Granada, Hospitales San Cecilio y Virgen de las Nieves y Atención Primaria de Granada, IBS, Granada, España.
authors.forename: M
authors.initials: M
authors.lastname: García-Valverde
authors.affiliation: UGC de Nefrología, Complejo Hospitalario Universitario de Granada, Hospitales San Cecilio y Virgen de las Nieves y Atención Primaria de Granada, IBS, Granada, España.
authors.forename: J A
authors.initials: JA
authors.lastname: Bravo-Soto
keywords: Función renal; Magnetic resonance; Poliquistosis renal; Renal function; Renal polycystic; Renal volume; Resonancia magnética; Volumen renal