title: Sporadic versus inflammatory bowel disease-related colorectal adenocarcinoma: lessons learned from a single institution experience.
abstract: OBJECTIVE
  Inflammatory bowel disease (IBD) - related colorectal adenocarcinoma (CAC) is known to impose a less favorable prognosis than its sporadic counterpart. The determining factor in the prognosis of IBD patients is the early endoscopic detection of commonly occult pre-cancerous lesions. This retrospective study attempted to highlight the distinctive features of IBD-related CAC, as well as the importance of implementing an acceptable surveillance protocol in IBD patients.
  
  
  METHODS
  The medical records and biopsies of all IBD patients undergoing surgery and of surgical patients with sporadic CAC, admitted in the 5-year period 2010-2014, were examined. Overall, 26 clinicopathological parameters were collected and compared between the two groups.
  
  
  RESULTS
  A total of 370 patients with sporadic CAC and 103 patients with IBD were included in the study, of which 8.7% (9/103) proved to have CAC. Cancer in IBD patients appeared at a younger age, had a larger maximum diameter and was more likely to have multiple synchronous locations and a signet-ring cell differentiation (p<0.05). Only 25% of IBD patients with CAC had previously followed correct surveillance.
  
  
  CONCLUSIONS
  The aggressive features of IBD-related CAC, as well as the rising incidence of poorly-surveilled IBD patients that eventually progress to cancer, reflect the necessity of establishing dedicated IBD centers for their optimal follow-up.
authors.affiliation: 2nd Department of Surgery, Medical School, University of Athens, Athens, Greece.
authors.forename: Georgios-Antonios
authors.initials: GA
authors.lastname: Sideris
authors.forename: Aggeliki
authors.initials: A
authors.lastname: Sardeli
authors.forename: Georgios
authors.initials: G
authors.lastname: Sachtouris
authors.forename: Ioanna
authors.initials: I
authors.lastname: Segkou
authors.forename: Agatha
authors.initials: A
authors.lastname: Kondi-Pafiti
authors.forename: Ioannis
authors.initials: I
authors.lastname: Papaconstantinou
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000209:etiology*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies