title: Group 1 CD1-restricted T cells and the pathophysiological implications of self-lipid antigen recognition.
abstract: T cell responses are generally regarded as specific for protein-derived peptide antigens. This is based on the molecular paradigm dictated by the T cell receptor (TCR) recognition of peptide-major histocompatibility complexs, which provides the molecular bases of the specificity and restriction of the T cell responses. An increasing number of findings in the last 20 years have challenged this paradigm, by showing the existence of T cells specific for lipid antigens presented by CD1 molecules. CD1-restricted T cells have been proven to be frequent components of the immune system and to recognize exogenous lipids, derived from pathogenic bacteria, as well as cell-endogenous self-lipids. This represents a young and exciting area of research in immunology with intriguing biological bases and a potential direct impact on human health.
authors.affiliation: Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Dellabona
authors.affiliation: Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Consonni
authors.affiliation: Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.
authors.forename: C
authors.initials: C
authors.lastname: de Lalla
authors.affiliation: Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Casorati
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology; D018949:Antigens, CD1 / Q000235:genetics / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology; D052179:Antigens, Plant / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity; D004926:Escherichia coli / Q000276:immunology; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007938:Leukemia / Q000276:immunology; D008055:Lipids / Q000276:immunology*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011058:Pollen / Q000276:immunology; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D017634:Self Tolerance / Q000276:immunology*; D013045:Species Specificity; D037182:T-Cell Antigen Receptor Specificity
chemical_list: D000942:Antigens, Bacterial; D018949:Antigens, CD1; D000951:Antigens, Neoplasm; D052179:Antigens, Plant; D001324:Autoantigens; D008055:Lipids
keywords: CD1; NKT cells; autoreactivity; leukemia; lipid antigens