title: Sensitization to reactive diluents and hardeners in epoxy resin systems. IVDK data 2002-2011. Part II: concomitant reactions.
abstract: BACKGROUND
  Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems (ERSs). Because of chemical similarities, immunological cross-reactivity may occur.
  
  
  OBJECTIVE
  To analyse concomitant reactivity among reactive diluents and hardeners in the patients concerned, as one integral part of a research project on the sensitizing capacity of ERSs (FP-0324).
  
  
  METHODS
  A retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2002-2011, was performed.
  
  
  RESULTS
  There was close concomitant reactivity to 1,6-hexanediol diglycidyl ether and 1,4-butanediol diglycidyl ether (1,4-BDDGE), and to phenyl glycidyl ether (PGE) and cresyl glycidyl ether (CGE), whereas reactions to p-tert-butylphenyl glycidyl ether occurred more independently from those to PGE and CGE. Concomitant reactions to butyl glycidyl ether and 1,4-BDDGE may point to a common allergenic compound derived from the metabolism of 1,4-BDDGE. Among the structurally more diverse group of hardeners, there was no evidence of immunological cross-reactions.
  
  
  CONCLUSIONS
  More detailed knowledge of cross-reactivity among ERS components facilitates the interpretation of patch test results and will allow safer ERSs to be composed in the future.
authors.affiliation: Information Network of Departments of Dermatology, University of Göttingen, 37075, Göttingen, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Geier
authors.affiliation: Information Network of Departments of Dermatology, University of Göttingen, 37075, Göttingen, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Lessmann
authors.affiliation: Department of Dermatology, University of Essen, 45122, Essen, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Hillen
authors.affiliation: Department of Dermatology, Environmental Medicine, and Health Theory, University of Osnabrück, 49069, Osnabrück, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Skudlik
authors.affiliation: Department of Dermatology, University of Heidelberg, 69115, Heidelberg, Germany.|Department of Dermatology, University of Lübeck, 23538, Lübeck, Germany.|Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway Research Centre North, Member of the German Centre for Lung Research, 23845, Borstel, Germany.
authors.forename: Uta
authors.initials: U
authors.lastname: Jappe
mesh_terms: D000328:Adult; D001317:Austria; D002072:Butylene Glycols / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology; D009783:Dermatitis, Occupational / Q000453:epidemiology* / Q000209:etiology; D004852:Epoxy Compounds / Q000009:adverse effects*; D004853:Epoxy Resins / Q000009:adverse effects; D005260:Female; D005858:Germany; D006229:Hand Dermatoses / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D013557:Switzerland; D055815:Young Adult
chemical_list: D002072:Butylene Glycols; D004852:Epoxy Compounds; D004853:Epoxy Resins; C414962:1,6-hexanediol diglycidyl ether; C014376:1,4-bis(2,3-epoxypropoxy)butane
keywords: concomitant reactivity; cross-reactivity; epoxy resin systems; hardeners; occupational contact allergy; reactive diluents