title: Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin.
abstract: The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.
authors.affiliation: International Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia. yura@tomo.nsc.ru.|Novosibirsk State University, Novosibirsk, Russia. yura@tomo.nsc.ru.
authors.forename: L V
authors.initials: LV
authors.lastname: Yanshole
authors.affiliation: International Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.|Novosibirsk State University, Novosibirsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Yanshole
authors.affiliation: International Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Snytnikova
authors.affiliation: Novosibirsk State Regional Clinical Hospital, Novosibirsk, Russia.
authors.forename: A Zh
authors.initials: AZh
authors.lastname: Fursova
authors.affiliation: Institute of Cytology and Genetics of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Kolosova
authors.affiliation: International Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.|Novosibirsk State University, Novosibirsk, Russia.
authors.forename: Yu P
authors.initials: YP
authors.lastname: Tsentalovich
authors.affiliation: International Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk, Russia.|Novosibirsk State University, Novosibirsk, Russia.
authors.forename: R Z
authors.initials: RZ
authors.lastname: Sagdeev
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002386:Cataract / Q000188:drug therapy* / Q000378:metabolism*; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000008:administration & dosage*; D005978:Glutathione / Q000378:metabolism; D007700:Kinetics; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism; D009883:Ophthalmic Solutions; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D010971:Plastoquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D055503:Protein Multimerization; D051381:Rats; D038201:alpha-Crystallins / Q000378:metabolism*; D038204:beta-Crystallins / Q000378:metabolism
chemical_list: C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D016166:Free Radical Scavengers; D009883:Ophthalmic Solutions; D038201:alpha-Crystallins; D038204:beta-Crystallins; D005978:Glutathione; D010971:Plastoquinone