title: Toward Treating to Target in Psoriatic Arthritis.
abstract: The concept "treat to target" in rheumatology was first developed for rheumatoid arthritis. A similar attempt to develop such an approach for spondyloarthritis was unsuccessful because the assessment tools and target of therapy had not been developed. In psoriatic arthritis (PsA), composite indices to assess disease activity, disease state, and responsiveness have been developed and can be used as targets. There are a number of definitions for remission, but none are widely accepted. However, a state of minimal disease activity has been defined. There is evidence now that the treat-to-target approach is feasible, using the minimal disease activity state as a target and devising a tight control approach, which is superior to standard of care. Further work will determine the best target and the best approach to reach it.
authors.affiliation: From the University of Toronto, Psoriatic Arthritis Program, Western Research Institute, University Health Network, Toronto, Ontario, Canada.D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto; Senior Scientist, Toronto Western Research Institute; Director, Psoriatic Arthritis Program, University Health Network. dafna.gladman@utoronto.ca.
authors.forename: Dafna D
authors.initials: DD
authors.lastname: Gladman
mesh_terms: D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D019091:Critical Pathways / Q000592:standards; D019983:Guideline Adherence; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D012074:Remission Induction; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: MINIMAL DISEASE ACTIVITY; PSORIATIC ARTHRITIS; TREATING TO TARGET