title: Oxygen administration at birth in preterm infants: a retrospective analysis.
abstract: OBJECTIVE
  The aim of the study was to retrospectively investigate the association between initial oxygen concentration in delivery room and short-term outcomes in preterm infants.
  
  
  METHODS
  Data from infants needing neonatal resuscitation, born at our department between January 2008 and December 2011, were analyzed. Patients were divided into three groups based on gestational age: between 32 and 36 weeks, between 31 and 28 weeks, and below 28 weeks.
  
  
  RESULTS
  The administration of each additional unit of oxygen up to 50% showed an association with a 5% increased need for mechanical ventilation (MV) in the neonatal intensive care unit in infants between 32 and 36 weeks [adjusted odds ratio 1.1, 95% confidence interval (CI) 1.04-1.1] and infants between 28 and 31 weeks (adjusted odds ratio 1.12, 95% CI 1.08-1.44). On the contrary, in infants below 28 weeks, increasing initial concentration of supplementary oxygen did not show any association with MV.
  
  
  CONCLUSIONS
  Initial oxygen concentration seems to be associated with increased MV in the NICU. Our observations further stress the need for randomized controlled studies in order to obtain definitive recommendations for the optimal initial oxygen concentration during neonatal resuscitation of preterm infants.
authors.affiliation: a NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università Degli Studi Di Milano , Milan , Italy and.
authors.forename: Maria
authors.initials: M
authors.lastname: Pierro
authors.affiliation: a NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università Degli Studi Di Milano , Milan , Italy and.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ciralli
authors.affiliation: a NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università Degli Studi Di Milano , Milan , Italy and.
authors.forename: Mariarosa
authors.initials: M
authors.lastname: Colnaghi
authors.affiliation: a NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università Degli Studi Di Milano , Milan , Italy and.
authors.forename: Mara
authors.initials: M
authors.lastname: Vanzati
authors.affiliation: a NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università Degli Studi Di Milano , Milan , Italy and.
authors.forename: Domenica
authors.initials: D
authors.lastname: Mercadante
authors.affiliation: b Epidemiology Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico , Milan , Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Consonni
authors.affiliation: a NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università Degli Studi Di Milano , Milan , Italy and.
authors.forename: Fabio
authors.initials: F
authors.lastname: Mosca
mesh_terms: D003696:Delivery Rooms; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D015931:Intensive Care, Neonatal; D010100:Oxygen / Q000008:administration & dosage*; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012151:Resuscitation; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D010100:Oxygen
keywords: Guidelines; mechanical ventilation; neonatal resuscitation; oxygen; preterm