title: Effect of the early intensive multifactorial therapy on the cardiovascular risk in patients with newly diagnosed type 2 diabetes: an observational, prospective study.
abstract: OBJECTIVE
  We assessed if early intensive interventions improve the glycemic control and the modifiable cardiovascular diseases risk factors in Romanian patients with newly diagnosed type-2 diabetes during the first year follow-up period.
  
  
  METHODS
  This was an observational, prospective study: 69 subjects were included in the analysis; each of them received intensive multi-factorial pharmacologic treatment and therapeutic education targeting hyperglycemia, weight, hypertension and dyslipidemia. Disease monitoring was done at months 0, 1, 3, 6 and 12 by assessment of anthropometric measurements, arterial blood pressure and biochemical parameters. The cardiovascular diseases risk factors were calculated using the United Kingdom Prospective Diabetes Study Risk Engine.
  
  
  RESULTS
  The mean age at diagnosis was 53.61±10.66 years. All anthropometric variables (body weight, body mass index, waist circumference, visceral fat area, percentage of body fat), except for skeletal muscle mass, significantly decreased overtime. The majority of the biochemical parameters significantly decreased overtime. The non-fatal/fatal coronary heart disease risk significantly decreased at month 12 (9.74 [p<0.05] and 4.84 [p<0.05], respectively) compared to month 0 (19.66 and 11.10, respectively); a similar trend of the non-fatal/fatal stroke (risk at month 12, 8.30 [p<0.05] and 1.04 [p<0.05], respectively, while at month 0, 7.89 and 1.38, respectively) was recorded.
  
  
  CONCLUSIONS
  Early multi-factorial treatment and intensive lifestyle interventions in patients newly diagnosed with type-2 diabetes could decrease with approximately 50% the rate of cardiovascular disease risk.
authors.affiliation: Diabetes, Nutrition and Metabolic Diseases Department, County Emergency Hospital, Bistrita-Nasaud, Romania.
authors.forename: Ramona Maria
authors.initials: RM
authors.lastname: Stefan
authors.affiliation: Diabetes, Nutrition and Metabolic Diseases Department, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca and Private Practice, Baia Mare, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Nita
authors.affiliation: Diabetes, Nutrition and Metabolic Diseases Department, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca and Private Health Network Regina Maria, Cluj-Napoca, Romania.
authors.forename: Anca
authors.initials: A
authors.lastname: Craciun
authors.affiliation: Clinical Consulting SRL.
authors.forename: Adriana
authors.initials: A
authors.lastname: Rusu
authors.affiliation: Diabetes, Nutrition and Metabolic Diseases Department, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca and Private Health Network Regina Maria, Cluj-Napoca, Romania.
authors.forename: Nicolae
authors.initials: N
authors.lastname: Hancu
keywords: cardiovascular risk; multi-factorial therapy; newly diagnosed patients; type-2 diabetes