title: The Role of Cytokines and Chemokines in Filovirus Infection.
abstract: Ebola- and marburgviruses are highly pathogenic filoviruses and causative agents of viral hemorrhagic fever. Filovirus disease is characterized by a dysregulated immune response, severe organ damage, and coagulation abnormalities. This includes modulation of cytokines, signaling mediators that regulate various components of the immune system as well as other biological processes. Here we examine the role of cytokines in filovirus infection, with an emphasis on understanding how these molecules affect development of the antiviral immune response and influence pathology. These proteins may present targets for immune modulation by therapeutic agents and vaccines in an effort to boost the natural immune response to infection and/or reduce immunopathology.
authors.affiliation: United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Frederick, MD 21702, USA. sandra.l.bixler.ctr@mail.mil.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Bixler
authors.affiliation: United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Frederick, MD 21702, USA.
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Goff
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D016563:Filoviridae / Q000276:immunology*; D018702:Filoviridae Infections / Q000276:immunology* / Q000473:pathology*; D006801:Humans
chemical_list: D016207:Cytokines
keywords: Ebola; Filovirus; Marburg; chemokine; cytokine; immunopathology