title: Property and current clinical applications of mammal hyaluronidase.
abstract: Hyaluronidase (Hyal), which is related to mammalian diseases, is greatly significant for mammal. It is the major enzyme for degrading hyaluronan (HA), which is a linear high molecular polymer that is ubiquitous in mammalian extracellular matrix. Previous studies suggested that the levels of Hyals play significant roles in predicting, determining and curing many diseases. This review summarizes previous studies on the classification and biophysical and therapeutic applications of mammalian Hyals and focuses on the current medicinal and clinical applications of Hyals.
authors.affiliation: Master of Biochemistry, Department of Bioengineering, Shanghai Institute of Technology, China. qqli@sit.edu.cn.
authors.forename: S-H
authors.initials: SH
authors.lastname: Lv
authors.forename: S-F
authors.initials: SF
authors.lastname: Rong
authors.forename: B-G
authors.initials: BG
authors.lastname: Cai
authors.forename: S-M
authors.initials: SM
authors.lastname: Guan
authors.forename: Q-Q
authors.initials: QQ
authors.lastname: Li
mesh_terms: D000818:Animals; D005109:Extracellular Matrix; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism*; D008322:Mammals; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology
chemical_list: D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase