title: Chromatin-remodeling and the initiation of transcription.
abstract: The nucleosome serves as a general gene repressor by the occlusion of regulatory and promoter DNA sequences. Repression is relieved by the SWI/SNF-RSC family of chromatin-remodeling complexes. Research reviewed here has revealed the essential features of the remodeling process.
authors.affiliation: Department of Structural Biology,Stanford University School of Medicine,Stanford,CA 94305,USA.
authors.forename: Yahli
authors.initials: Y
authors.lastname: Lorch
authors.affiliation: Department of Structural Biology,Stanford University School of Medicine,Stanford,CA 94305,USA.
authors.forename: Roger D
authors.initials: RD
authors.lastname: Kornberg
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D002843:Chromatin / Q000737:chemistry*; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone; D020285:Cryoelectron Microscopy; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry; D006657:Histones / Q000737:chemistry; D006801:Humans; D009707:Nucleosomes / Q000737:chemistry; D011401:Promoter Regions, Genetic; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D009707:Nucleosomes; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D004247:DNA
keywords: RSC; nucleosome; nucleosome-free region