title: Uveitis and glaucoma: new insights in the pathogenesis and treatment.
abstract: Glaucoma is a potentially blinding complication of uveitis, where intraocular inflammation, secondary corticosteroid response, and varying types and degrees of angle abnormalities contribute to its pathogenesis. Management of uveitic glaucoma remains challenging. Treatment is targeted at reducing the inflammation and lowering the intraocular pressure. Recent studies have highlighted the role of viruses, such as cytomegalovirus, herpes simplex virus, and more recently Ebola virus, in the pathogenesis of uveitic glaucoma. Antiviral therapy may be beneficial in eyes with detectable viral DNA. The success of glaucoma surgery is decreased in eyes with uveitic glaucoma, and surgical interventions are associated with a higher incidence of postoperative complications. Novel glaucoma surgical and laser treatments may improve the predictability of surgery for uveitic glaucoma, but these require further evaluation.
authors.affiliation: Glaucoma Service, Moorfields Eye Hospital, London, UK; Department of Ophthalmology, National University Health System, Singapore, Singapore; Singapore Eye Research Institute, Singapore, Singapore.
authors.forename: Chelvin C A
authors.initials: CC
authors.lastname: Sng
authors.affiliation: Singapore Eye Research Institute, Singapore, Singapore; Singapore National Eye Centre, Singapore, Singapore.
authors.forename: Marcus
authors.initials: M
authors.lastname: Ang
authors.affiliation: Glaucoma Service, Moorfields Eye Hospital, London, UK; Department of Ophthalmology, National University Health System, Singapore, Singapore; National Institute for Health Research, Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, UK; Department of Epidemiology and Genetics, Institute of Ophthalmology, University College, London, UK. Electronic address: keith@keithbarton.co.uk.
authors.forename: Keith
authors.initials: K
authors.lastname: Barton
mesh_terms: D005901:Glaucoma / Q000209:etiology*; D006801:Humans; D014605:Uveitis / Q000150:complications*
keywords: Glaucoma; Ocular infections; Ocular surgery; Uveitis