title: [The Role of Iron and Alpha-synuclein Interacting in Parkinson's Disease].
abstract: Both iron and alpha-synuclein accumulation are one of hallmarks of Parkinson's disease (PD). Alpha-synuclein aggregation is often accompanied by abnormal accumulation of iron, indicating that there is a certain link between iron and alpha-synuclein aggregation. Iron promotes alpha-synuclein aggregation by increasing its synthesis and decreasing its degradation. Also, alpha-synuclein regulates iron metabolism through its ferrireductase activity. In this review, we will describe the roles of iron and alpha-synuclein in PD pathogenesis, and the mechanisms of iron and alpha-synuclein interaction.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Song
authors.forename: Hua-min
authors.initials: HM
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Jun-xia
authors.initials: JX
authors.lastname: Xie
mesh_terms: D006801:Humans; D007501:Iron; D010300:Parkinson Disease; D051844:alpha-Synuclein
chemical_list: D051844:alpha-Synuclein; D007501:Iron