title: PARP inhibition: A promising therapeutic target in ovarian cancer.
abstract: Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery. Despite several adjustments occurred in cytotoxic drug in last decades, most patients continue to relapse, and no significant enhancement has been reached in the overall survival. The development of drug resistance and the recurrence of disease have prompted the investigations of other targets that can be used in the treatment of ovarian cancers. Among such targets, polyadenosine diphosphate-ribose polymerase (PARP) represents a novel way to target specific patways involved in tumor growth. PARP accelerates the reaction of the polyADP-ribosylation of proteins implicated in DNA repair. PARP inhibitors have shown activity in cancers with BRCA mutations, with other deficient DNA repair genes or signaling pathways that modulate DNA repair, or in association with DNA damaging agents not involved in DNA repair dysfunction. A number of inhibitors for PARP has been developed, and such drugs are under investigation in clinical trials to identify their impact in the treatment of ovarian cancers. This review aims to summarize the recent researches and clinical progress on PARP inhibitors as novel target agents in ovarian cancer.
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: A
authors.initials: A
authors.lastname: Musella
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: C
authors.initials: C
authors.lastname: Marchetti
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy marialuisa.gasparri&commat;uniroma1.it.
authors.forename: M L
authors.initials: ML
authors.lastname: Gasparri
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: L
authors.initials: L
authors.lastname: Salerno
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: A
authors.initials: A
authors.lastname: Casorelli
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: L
authors.initials: L
authors.lastname: Domenici
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: L
authors.initials: L
authors.lastname: Imperiale
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: I
authors.initials: I
authors.lastname: Ruscito
authors.affiliation: RLMC Department of Obstetrics and Gynecology Lahore Pakistan.
authors.forename: T
authors.initials: T
authors.lastname: Abdul Halim
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: I
authors.initials: I
authors.lastname: Palaia
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: V
authors.initials: V
authors.lastname: Di Donato
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pecorini
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: M
authors.initials: M
authors.lastname: Monti
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: L
authors.initials: L
authors.lastname: Muzii
authors.affiliation: University Sapienza of Rome Department of Gynecology, Obstetrics and Urological Sciences Rome Italy.
authors.forename: P B
authors.initials: PB
authors.lastname: Panici
mesh_terms: D000818:Animals; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery; D000067856:Poly(ADP-ribose) Polymerase Inhibitors / Q000627:therapeutic use*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: D001952:Bridged-Ring Compounds; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D043823:Taxoids; C080625:taxane; D011065:Poly(ADP-ribose) Polymerases