title: GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog.
abstract: GM2 gangliosidosis variant 0 (Sandhoff disease, SD) is a fatal, progressive, neurodegenerative lysosomal storage disease caused by simultaneous deficiencies of acid β-hexosaminidases A and B. Canine SD has so far been identified only in two purebreeds. In this article, we present the case of a 10 mo old, male dog of mixed breed that developed progressive neurological signs including ataxia, postural deficit, and visual deficits and finally died at the age of 21 mo. The dog was diagnosed with SD on the basis of the results of biochemical and histopathological analyses. This is the third report of canine SD and the first time it has been identified in a mixed breed.
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Moeko
authors.initials: M
authors.lastname: Kohyama
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Akira
authors.initials: A
authors.lastname: Yabuki
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Kawasaki
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawaguchi
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Naoki
authors.initials: N
authors.lastname: Miura
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kitano
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Toshinori
authors.initials: T
authors.lastname: Onitsuka
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Mohammad Mahbubur
authors.initials: MM
authors.lastname: Rahman
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Noriaki
authors.initials: N
authors.lastname: Miyoshi
authors.affiliation: From the Laboratories of Clinical Pathology (M.K., A.Y., M.M.R., O.Y.), Behavioral Physiology and Ecology (Y.Ka.), Veterinary Histopathology (H.K., N.Miy.), and Diagnostic Imaging (N.Miu.) of the Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan; Kitano Animal Hospital, Izumi, Japan (Y.Ki.); and Minamata Animal Hospital, Minamata, Japan (T.O.).
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D008297:Male; D012497:Sandhoff Disease / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*