title: CHANGES IN C-REACTIVE PROTEIN AND BIOCHEMICAL PROFILE IN PRESCHOOL CHILDREN WITH OBESITY.
abstract: BACKGROUND
  the childhood obesity is a serious public health problem because if weight gain continues, complications such as insulin resistance, dyslipidemia, orthopedic disorders, sleep apnea, and metabolic syndrome may occur in other stages of child development.
  
  
  OBJECTIVE
  the objective of this study was to evaluate C-reactive protein (CRP) concentrations, lipid profiles, and glucose levels in obese children three to five years of age and compare them to eutrophic children.
  
  
  METHODS
  in this study, 100 children aged three to five years were selected and divided into two groups (n = 50 per group): a group of eutrophic children (< 84th percentile) and a group of obese children (> 95th percentile). An anthropometric evaluation and quantification of plasma levels of ultrasensitive CRP, triglycerides, cholesterol, LDL-C, HDL-C, and glucose were performed.
  
  
  RESULTS
  the data showed a significant increase in obese children with regard to height (p < 0.005), weight (p < 0.0001), body mass index (p < 0.0001), ultrasensitive CRP (p < 0.0001), triglycerides (p < 0.0001), LDL (p < 0.0001), and glucose levels (p < 0.0001) as well as decreased levels of HDL (p < 0.0001) compared to eutrophic children.
  
  
  CONCLUSIONS
  metabolic changes that occur in obese preschool children are characterized by increases in inflammatory markers and lipid profiles. Considering that during preschool age the programming and number of adipocytes that will remain with the individual for the rest of their life are determined, this stage is crucial in the development of complications associated with obesity.
authors.affiliation: Departamento de Fisología, Facultad de Medicina, UNAM. Hospital Pediátrico San Juan de Aragón, Secretaria de Salud del Distrito Federal.. srivas@unam.mx.
authors.forename: Enrique
authors.initials: E
authors.lastname: Carmona-Montesinos
authors.affiliation: Hospital Materno Pediátrico Xochimilco, Secretaría de Salud del Distrito Federal. México.. srivas@unam.mx.
authors.forename: Zugaila
authors.initials: Z
authors.lastname: Ruiz-Fragoso
authors.affiliation: Departamento de Fisología, Facultad de Medicina, UNAM.. srivas@unam.mx.
authors.forename: Graciela
authors.initials: G
authors.lastname: Ponce-Hinojosa
authors.affiliation: Departamento de Fisología, Facultad de Medicina, UNAM.. srivas@unam.mx.
authors.forename: Selva
authors.initials: S
authors.lastname: Rivas-Arancibia
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism; D009752:Nutritional Status; D009765:Obesity / Q000097:blood*; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D008055:Lipids; D002097:C-Reactive Protein