title: The Effectiveness of Midazolam for Preventing Postoperative Nausea and Vomiting: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  Previous randomized controlled trials regarding the effectiveness of perioperative midazolam in preventing postoperative nausea and vomiting (PONV) have produced conflicting results. Consequently, the present systematic review was performed to assess the effect of perioperative administration of midazolam on PONV.
  
  
  METHODS
  The MEDLINE®, Embase, and Cochrane Central Register of Controlled Trials databases were searched to identify all randomized controlled trials that investigated the effectiveness of midazolam under general anesthesia. The primary end points were defined as postoperative nausea (PON), postoperative vomiting (POV), and PONV.
  
  
  RESULTS
  From 16 studies, 1433 patients were included in the final analysis. Compared with the control group, patients who received midazolam showed a lower overall incidence of PON (risk ratio [RR], 0.51; 95% confidence interval [CI], 0.40-0.65; I = 35%; number needed to treat [NNT] = 6; number of included studies [n] = 11), POV (RR, 0.46; 95% CI, 0.33-0.65; I = 0%; NNT = 8; n = 10), and PONV (RR, 0.45; 95% CI, 0.36-0.57; I = 31%; NNT = 3; n = 7).
  
  
  CONCLUSIONS
  Perioperative administration of midazolam was effective in preventing PON, POV, and PONV.
authors.affiliation: From the Department of Anaesthesiology and Pain Medicine, Inje University, Seoul Paik Hospital, Seoul, Korea; and Department of Anaesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Ahn
authors.forename: Hyun
authors.initials: H
authors.lastname: Kang
authors.forename: Geun Joo
authors.initials: GJ
authors.lastname: Choi
authors.forename: Chong Wha
authors.initials: CW
authors.lastname: Baek
authors.forename: Yong Hun
authors.initials: YH
authors.lastname: Jung
authors.forename: Young Choel
authors.initials: YC
authors.lastname: Woo
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000932:Antiemetics; D008874:Midazolam