title: [The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux].
abstract: OBJECTIVE
  To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux(LPR).
  
  
  METHODS
  The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to October of 2014. All of them were randomly divided into group A and B. The individuals in group A (30 cases) taked golden voice capsule to treat for 3 months, while the individuals in group B (30 cases) taked golden voice capsule and omeprazole to treat for 3 months. The data about reflux symptom index (RSI), reflux finding score (RFS) and voice handicap index (VHI)from the first month to the third month after treatment were recorded and compared group A with group B.
  
  
  RESULTS
  The scores of RSI and RFS in patients (60 cases) before treatment were significantly correlated with their VHI (r=0. 823, P<0. 01; r=0. 873, P<0. 01). The score changes of RSI and VHI from the first to the third month after treatment in group B were significantly higher than those in group A (P<0. 01). Meanwhile, the score changes of RFS from the third month after treatment in group B were significantly higher than those in group A (t=8. 307, P<. 01), but the differences were not significant for RFS from the first to the second month after treatment between group A and group B(t=1. 128, P>0. 05; t=0. 376, P> 0. 05).
  
  
  CONCLUSIONS
  PPI therapy could significantly alleviate the hoarseness symptom in LPR patients.
authors.forename: Huanan
authors.initials: H
authors.lastname: Luo
authors.forename: Sijing
authors.initials: S
authors.lastname: Ma
authors.forename: Yin
authors.initials: Y
authors.lastname: Gao
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.forename: Jin
authors.initials: J
authors.lastname: Hou
authors.forename: Min
authors.initials: M
authors.lastname: Xu
mesh_terms: D006685:Hoarseness / Q000188:drug therapy*; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000188:drug therapy*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*
chemical_list: D054328:Proton Pump Inhibitors