title: Gender differences in the association of hypertension with gamma-glutamyltransferase and alanine aminotransferase levels in Chinese adults in Qingdao, China.
abstract: The aim of the study was to study the associations of hypertension with gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT) levels. Data of 3575 men and 5504 women were analyzed. Multivariate logistic regression analysis was performed to estimate the odds ratio (OR) for hypertension with GGT and ALT. Compared with the lowest quartile, the multivariate adjusted ORs for hypertension were 0.97 (0.79, 1.19) in men and 0.88 (0.74, 1.04) in women for ALT and 2.29 (1.68, 3.14) and 1.52 (1.27, 1.83) for GGT in the highest quartile group. The ORs for hypertension in the low waist circumference category were 2.61 (1.56, 4.36) in men and 1.41 (0.94, 2.12) in women and in the high waist circumference category 4.01 (2.21, 7.29) and 2.26 (1.54, 3.32) for GGT. The elevated GGT, but not ALT, was associated with the presence of the hypertension in men and women. The association is stronger in obese men and women than in their lean counterparts.
authors.affiliation: Department of Non-communicable Disease Prevention, Shandong Province Center for Disease Control and Prevention, Jinan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Non-communicable Disease Prevention, Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Non-communicable Disease Prevention, Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China; Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
authors.forename: Feng
authors.initials: F
authors.lastname: Ning
authors.affiliation: Department of Non-communicable Disease Prevention, Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
authors.forename: Zengchang
authors.initials: Z
authors.lastname: Pang
authors.affiliation: Department of Geriatrics, Qilu Hospital of Shandong University, Key Laboratory of Cardiovascular Proteomics of Shandong Province, Jinan, China. Electronic address: qieqiluhospital@126.com.
authors.forename: Liangyi
authors.initials: L
authors.lastname: Qie
authors.affiliation: Department of Research & Development, Astrazeneca, Mölndal, Sweden.
authors.forename: Qing
authors.initials: Q
authors.lastname: Qiao
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D044466:Asian People / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood; D001795:Blood Pressure Determination / Q000379:methods; D002681:China / Q000453:epidemiology; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D016017:Odds Ratio; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D012727:Sex Characteristics; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase
keywords: Alanine aminotransferase; gamma–glutamyltransferase; gender; hypertension