title: Comorbidity and pathogenic links of chronic spontaneous urticaria and systemic lupus erythematosus--a systematic review.
abstract: Chronic spontaneous urticaria (CSU) is a common mast cell-driven disease characterized by the development of wheals (hives), angioedema (AE), or both for > 6 weeks. It is thought that autoimmunity is a common cause of CSU, which is often associated with autoimmune thyroiditis, whereas the link to other autoimmune disorders such as systemic lupus erythematosus (SLE) has not been carefully explored. Here, we systematically reviewed the existing literature for information on the prevalence of CSU in SLE (and vice versa) and we examined the possible clinical and pathogenetic relationship between CSU and SLE. The prevalence of CSU and CSU-like rash in SLE was investigated by 42 independent studies and comorbidity in adult patients reportedly ranged from 0% to 21.9% and 0.4% to 27.5%, respectively (urticarial vasculitis: 0-20%). In children with SLE, CSU was reported in 0-1.2% and CSU-like rash in 4.5-12% (urticarial vasculitis: 0-2.2%). In contrast, little information is available on the prevalence of SLE in patients with CSU, and more studies are needed to determine the rate of comorbidity. Recent insights on IgG- and IgE-mediated autoreactivity suggest similarities in the pathogenesis of CSU and SLE linking inflammation and autoimmunity with the activation of the complement and coagulation system. Future studies of patients with either or both conditions could help to better define common pathomechanisms in CSU and SLE and to develop novel targeted treatment options for patients with CSU and SLE.
authors.affiliation: Department of Dermatology and Venereology, Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: P
authors.initials: P
authors.lastname: Kolkhir
authors.affiliation: Department of Dermatology and Venereology, Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: D
authors.initials: D
authors.lastname: Pogorelov
authors.affiliation: Department of Dermatology and Venereology, Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: O
authors.initials: O
authors.lastname: Olisova
authors.affiliation: Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Maurer
mesh_terms: D002908:Chronic Disease; D015897:Comorbidity; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000453:epidemiology*; D015995:Prevalence; D014581:Urticaria / Q000150:complications* / Q000453:epidemiology*