title: The impact of maternal hypothyroidism during pregnancy on neonatal outcomes: a systematic review and meta-analysis.
abstract: The effects of maternal hypothyroidism on neonatal outcomes were not definitely confirmed. We conduct a systematic review of the literatures on the impact of maternal hypothyroidism on neonatal outcomes. We searched Pubmed, Embase and the Cochrane Controlled Trials Register databases complemented by manual searches in article references without language restrictions published from 1946 to April 2015. Nine trials are included. For preterm birth in pregnancies of hypothyroidism women, there is an increased tendency (RR 1.18; 95% CI 0.99 to 1.40; p = 0.06). The same result is seen relating to the low birth weight (RR 1.31; 95% CI 1.00 to 1.72; p = 0.05). Regarding small for gestational age there is no significant increase. Children who were born from mothers with hypothyroidism during pregnancy have increased birth weight (MD 32.35, 95% CI 7.46 to 57.24; p = 0.01). The impact of maternal hypothyroidism shows a trend of reduced risk of large for gestational age (RR 1.17; 95% CI 0.99 to 1.38; p = 0.06). Our review suggests that mothers with hypothyroidism during pregnancy are more likely to give birth to children with higher birth weight or LGA, and L-T4 supplementation should be recommended. The risk of preterm birth and low birth weight also tends to be higher in children with hypothyroidism mothers.
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China.
authors.forename: Jiatong
authors.initials: J
authors.lastname: Hou
authors.affiliation: a Department of Endocrinology , Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College , Beijing , China and.
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.affiliation: a Department of Endocrinology , Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College , Beijing , China and.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhu
authors.affiliation: a Department of Endocrinology , Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College , Beijing , China and.
authors.forename: Hui
authors.initials: H
authors.lastname: Pan
authors.affiliation: a Department of Endocrinology , Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College , Beijing , China and.
authors.forename: Naishi
authors.initials: N
authors.lastname: Li
authors.affiliation: a Department of Endocrinology , Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College , Beijing , China and.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Yang
authors.affiliation: b School of Public Health, Peking Union Medical College , Beijing , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: a Department of Endocrinology , Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College , Beijing , China and.
authors.forename: Linjie
authors.initials: L
authors.lastname: Wang
authors.affiliation: b School of Public Health, Peking Union Medical College , Beijing , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: b School of Public Health, Peking Union Medical College , Beijing , China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: b School of Public Health, Peking Union Medical College , Beijing , China.
authors.forename: Lili
authors.initials: L
authors.lastname: You
authors.affiliation: a Department of Endocrinology , Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College , Beijing , China and.
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
mesh_terms: D001724:Birth Weight; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology*; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000453:epidemiology*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology*; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine
keywords: Birth weight; hypothyroidism; neonatal outcomes; pregnancy