title: The relationship between weight change and risk of hip fracture: meta-analysis of prospective studies.
abstract: The relationship between weight change and risk of hip fracture is still controversial. We searched PubMed and Embase for studies on weight change and risk of hip fracture. Eight prospective studies were included. The weight loss studies included 85592 participants with 1374 hip fractures, and the weight gain studies included 80768 participants with 732 hip fractures. Weight loss is more likely a risk factor of hip fracture, with an adjusted RR (Relative Risk) (95% CI) of 1.84 (1.45, 2.33). In contrast, weight gain can decrease the risk of hip fracture, with an adjusted RR (95% CI) of 0.73 (0.61, 0.89). Dose-response meta-analysis shows that the risk of hip fracture is an ascending curve, with an increase of weight loss above the line of RR = 1; this trend is consistent with the results of forest plots that examine weight loss and hip fracture. For weight gain and risk of hip fracture, the descending curve below the line of RR = 1; this trend is consistent with the results of forest plots that examine weight gain and hip fracture. Our meta-analysis suggests that weight loss may be a risk factor for hip fracture and that weight gain may be a protective factor for hip fracture.
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Qing-Bo
authors.initials: QB
authors.lastname: Lv
authors.affiliation: Department of Orthopaedics, Tianjin Hospital, Tianjin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Jin
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Hai-Chao
authors.initials: HC
authors.lastname: Xu
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Zhe-Yu
authors.initials: ZY
authors.lastname: Huang
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Hua-Zi
authors.initials: HZ
authors.lastname: Xu
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Yong-Long
authors.initials: YL
authors.lastname: Chi
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006620:Hip Fractures / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D015430:Weight Gain / Q000502:physiology*; D015431:Weight Loss / Q000502:physiology*