title: The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion.
abstract: Cardiac ischemia-reperfusion stimulates the renin-angiotensin system (RAS) associated with elevated levels of circulating angiotensin II. Numerous studies demonstrate that the antagonist for the angiotensin II type 1 receptor, losartan improves cardiac function in animal models of ischemia-reperfusion. Molecular mechanisms of the cardioprotective effects of RAS inhibitors on cardiac ischemia-reperfusion remain poorly understood, and are not associated with the anti-hypertensive action of these drugs. This Commentary focuses on the study published in the Journal of Pharmacy and Pharmaceutical Sciences, 2015, 18:112-123, that elucidates the role of SIRT3 in the cardioprotective action of losartan against ischemic-reperfusion injury. We provide comprehensive discussion of the role of mitochondria in the cardioprotective effects of losartan through SIRT3. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
authors.affiliation: Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR, USA.
authors.forename: Sabzali
authors.initials: S
authors.lastname: Javadov
authors.forename: Nelson
authors.initials: N
authors.lastname: Escobales
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D006801:Humans; D019808:Losartan / Q000008:administration & dosage*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D056566:Sirtuin 3 / Q000502:physiology*; D016896:Treatment Outcome; D018631:ras Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: C449676:AGTRAP protein, human; D048868:Adaptor Proteins, Signal Transducing; D002316:Cardiotonic Agents; C466093:SIRT3 protein, human; D056566:Sirtuin 3; D018631:ras Proteins; D019808:Losartan