title: Preparation of an Antibacterial Poly(ionic liquid) Graft Copolymer of Hydroxyethyl Cellulose.
abstract: Poly(ionic liquid)s (P(IL)s) of different degrees of polymerization (10, 50, and 100) were prepared via RAFT polymerization using an alkyne-terminated xanthate as transfer agent, with a monomer conversion of up to ∼80% and a ĐM of 1.5 for P(IL)100. Subsequently, P(IL) chains were coupled to (15)N-labeled azido-functionalized hydroxyethyl cellulose (HEC), forming graft copolymers of HEC with different chain length and graft densities, which were characterized using ((13)C and (15)N) CP-MAS NMR and FT-IR spectroscopies. The antibacterial activities of HEC-g-P(IL)s were tested against Escherichia coli and Staphylococcus aureus and were comparable to ampicillin, a well-known antibiotic, demonstrating efficient activity of the graft copolymers against bacteria. Moreover, HEC-g-P(IL)s were slightly more effective against E. coli than S. aureus. A decrease in graft density of P(IL)10 on the HEC backbone decreased the activity of the graft copolymers against both bacteria. These findings suggest that HEC-g-P(IL) could find applications as an antiseptic compound, for example, in paint formulation.
authors.affiliation: Department of Chemistry, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.|Biophysical Sciences Institute, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.
authors.forename: Fanny
authors.initials: F
authors.lastname: Joubert
authors.affiliation: School of Biological and Biomedical Sciences, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.|Biophysical Sciences Institute, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.
authors.forename: R Paul
authors.initials: RP
authors.lastname: Yeo
authors.affiliation: School of Biological and Biomedical Sciences, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.|Biophysical Sciences Institute, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Sharples
authors.affiliation: Ashland Speciality Ingredients , 1005 Route 202/206, Bridgewater, New Jersey 08807, United States.
authors.forename: Osama M
authors.initials: OM
authors.lastname: Musa
authors.affiliation: Department of Chemistry, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.|Biophysical Sciences Institute, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.|Centre for Sustainable Chemical Processes, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.
authors.forename: David R W
authors.initials: DR
authors.lastname: Hodgson
authors.affiliation: Department of Chemistry, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.|Biophysical Sciences Institute, Durham University , Science Laboratories, Durham DH1 3LE, United Kingdom.|Department of Materials Science and Engineering, Monash University , Clayton, Victoria 3800, Australia.|School of Engineering, University of Warwick , Coventry, CV4 7AL, United Kingdom.
authors.forename: Neil R
authors.initials: NR
authors.lastname: Cameron
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002247:Carbon Isotopes; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D052578:Ionic Liquids / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D009587:Nitrogen Isotopes; D009636:Norbornanes; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D013859:Thiocarbamates; D013871:Thiones / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001952:Bridged-Ring Compounds; D002247:Carbon Isotopes; D052578:Ionic Liquids; D009587:Nitrogen Isotopes; D009636:Norbornanes; D011108:Polymers; D013859:Thiocarbamates; D013871:Thiones; C046498:tricyclodecane-9-yl-xanthogenate; D000667:Ampicillin; D002482:Cellulose; C002283:hydroxyethylcellulose