title: Integration of ChREBP-Mediated Glucose Sensing into Whole Body Metabolism.
abstract: Since glucose is the principal energy source for most cells, many organisms have evolved numerous and sophisticated mechanisms to sense glucose and respond to it appropriately. In this context, cloning of the carbohydrate responsive element binding protein has unraveled a critical molecular link between glucose metabolism and transcriptional reprogramming induced by glucose. In this review, we detail major findings that have advanced our knowledge of glucose sensing.
authors.affiliation: Inserm U1016 Institut Cochin, Paris, France; CNRS UMR 8104, Paris, France; and Université Paris Descartes, Paris, France.
authors.forename: Floriane
authors.initials: F
authors.lastname: Baraille
authors.affiliation: Inserm U1016 Institut Cochin, Paris, France; CNRS UMR 8104, Paris, France; and Université Paris Descartes, Paris, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Planchais
authors.affiliation: Inserm U1016 Institut Cochin, Paris, France; CNRS UMR 8104, Paris, France; and Université Paris Descartes, Paris, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Dentin
authors.affiliation: Inserm U1016 Institut Cochin, Paris, France; CNRS UMR 8104, Paris, France; and Université Paris Descartes, Paris, France sandra.guilmeau@inserm.fr.
authors.forename: Sandra
authors.initials: S
authors.lastname: Guilmeau
authors.affiliation: Inserm U1016 Institut Cochin, Paris, France; CNRS UMR 8104, Paris, France; and Université Paris Descartes, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Postic
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism / Q000473:pathology; D020033:Protein Isoforms; D015398:Signal Transduction
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D005227:Fatty Acids; C116385:MLXIPL protein, human; D020033:Protein Isoforms; D005947:Glucose