title: Inflammatory Biomarkers in Refractory Congestive Heart Failure Patients Treated with Peritoneal Dialysis.
abstract: Proinflammatory cytokines play a pathogenic role in congestive heart failure. In this study, the effect of peritoneal dialysis treatment on inflammatory cytokines levels in refractory congestive heart failure patients was investigated. During the treatment, the patients reached a well-tolerated edema-free state and demonstrated significant improvement in NYHA functional class. Brain natriuretic peptide decreased significantly after 3 months of treatment and remained stable at 6 months. C-reactive protein, a plasma marker of inflammation, decreased significantly following the treatment. Circulating inflammatory cytokines TNF-α and IL-6 decreased significantly after 3 months of peritoneal dialysis treatment and remained low at 6 months. The reduction in circulating inflammatory cytokines levels may be partly responsible for the efficacy of peritoneal dialysis for refractory congestive heart failure.
authors.affiliation: Nephrology and Hypertension Institute, Sheba Medical Center and Sackler Faculty of Medicine, 5265601 Tel-Hashomer, Israel.
authors.forename: Margarita
authors.initials: M
authors.lastname: Kunin
authors.affiliation: Nephrology and Hypertension Institute, Sheba Medical Center and Sackler Faculty of Medicine, 5265601 Tel-Hashomer, Israel.
authors.forename: Vered
authors.initials: V
authors.lastname: Carmon
authors.affiliation: Heart Failure Service and Heart Institute, Sheba Medical Center and Sackler Faculty of Medicine, 5265601 Tel-Hashomer, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Arad
authors.affiliation: Nephrology and Hypertension Institute, Sheba Medical Center and Sackler Faculty of Medicine, 5265601 Tel-Hashomer, Israel.
authors.forename: Nomy
authors.initials: N
authors.lastname: Levin-Iaina
authors.affiliation: Heart Failure Service and Heart Institute, Sheba Medical Center and Sackler Faculty of Medicine, 5265601 Tel-Hashomer, Israel.
authors.forename: Dov
authors.initials: D
authors.lastname: Freimark
authors.affiliation: Nephrology and Hypertension Institute, Sheba Medical Center and Sackler Faculty of Medicine, 5265601 Tel-Hashomer, Israel.
authors.forename: Eli J
authors.initials: EJ
authors.lastname: Holtzman
authors.affiliation: Nephrology and Hypertension Institute, Sheba Medical Center and Sackler Faculty of Medicine, 5265601 Tel-Hashomer, Israel.
authors.forename: Dganit
authors.initials: D
authors.lastname: Dinour
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000628:therapy*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000628:therapy*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010530:Peritoneal Dialysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein