title: Persistent γδ T large granular lymphocytosis in a patient with refractory pure red cell aplasia, celiac disease, and chronic hepatitis B infection.
abstract: The disorders of large granular lymphocytes include reactive proliferation as well as indolent or aggressive neoplasms of cytotoxic T cells, γδ T cells, and natural killer (NK) cells. They are associated with autoimmune and infectious disorders and have varied immunophenotypic features. We report a case, which highlights this complex association of autoimmune and infectious diseases with large granular lymphocytosis, the overlapping spectrum of large granular lymphocyte leukemias, and γδ T cell lymphomas as well as the difficulties in the diagnosis and management of these indolent T cell lymphomas in the usual clinical settings.
authors.forename: S
authors.initials: S
authors.lastname: Sreedharanunni
authors.forename: Mus
authors.initials: M
authors.lastname: Sachdeva
authors.forename: G
authors.initials: G
authors.lastname: Prakash
authors.affiliation: Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India.
authors.forename: R
authors.initials: R
authors.lastname: Das
mesh_terms: D001706:Biopsy; D002446:Celiac Disease / Q000150:complications*; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000150:complications* / Q000473:pathology; D008218:Lymphocytosis; D008297:Male; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000150:complications*; D013601:T-Lymphocytes / Q000473:pathology*