title: Neonatal EEG and neurodevelopmental outcome in preterm infants born before 32 weeks.
abstract: OBJECTIVE
  To assess the value of neonatal EEG for predicting non-optimal neurodevelopmental outcomes in very preterm infants, using a multimodal strategy of evaluation comprising brain imaging and clinical assessment.
  
  
  METHODS
  Between 2003 and 2009, we performed an observational, population-based study. Out of 2040 eligible preterm infants born before 32 weeks, 1954 were enrolled in the French regional Loire Infant Follow-Up Team (LIFT) cohort. 1744 (89%) of these completed the follow-up. Neonatal EEGs were recorded prospectively as two EEGs during the first 2 weeks of life and then one every 2 weeks up to 33 weeks.
  
  
  METHODS
  The neurodevelopmental outcome was assessed by physical examination, the Brunet-Lézine Test and/or the Age and Stages Questionnaire at 2 years of corrected age.
  
  
  RESULTS
  Of the 1744 infants assessed at 2 years, 422 had a non-optimal outcome. A total of 4804 EEGs were performed, and 1345 infants had at least one EEG. EEG abnormalities were predictive of non-optimal outcomes after controlling for confounding factors such as severe intracranial lesions detected by brain imaging. Transient moderate and severe abnormalities were independent predictors of non-optimal outcomes with an OR and 95% CI of 1.49 (1.08 to 2.04) and 2.38 (1.49 to 3.81), respectively. In the validation group, the predictive risk stratification tree identified severe abnormalities as a factor contributing to the prognosis of two subgroups: infants with severe cranial lesions and infants with a normal examination at discharge and without severe cranial lesions.
authors.affiliation: Department of Neonatal Medicine, University Hospital of Nantes, Nantes University, Nantes, France.
authors.forename: Maximilien
authors.initials: M
authors.lastname: Périvier
authors.affiliation: Department of Neonatal Medicine, University Hospital of Nantes, Nantes University, Nantes, France 'Loire Infant Follow-up Team' (LIFT) Network, Nantes, Pays de Loire, France Clinical Research Center, INSERM CIC004, University Hospital of Nantes, Nantes, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Rozé
authors.affiliation: 'Loire Infant Follow-up Team' (LIFT) Network, Nantes, Pays de Loire, France Department of Neonatal Medicine, Angers University, University Hospital of Angers, Angers, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Gascoin
authors.affiliation: Clinical Research Center, INSERM CIC004, University Hospital of Nantes, Nantes, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Hanf
authors.affiliation: 'Loire Infant Follow-up Team' (LIFT) Network, Nantes, Pays de Loire, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Branger
authors.affiliation: 'Loire Infant Follow-up Team' (LIFT) Network, Nantes, Pays de Loire, France Clinical Research Center, INSERM CIC004, University Hospital of Nantes, Nantes, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Rouger
authors.affiliation: 'Loire Infant Follow-up Team' (LIFT) Network, Nantes, Pays de Loire, France Department of Pediatric Neurology, Angers University, University Hospital of Angers, Angers, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Berlie
authors.affiliation: 'Loire Infant Follow-up Team' (LIFT) Network, Nantes, Pays de Loire, France Department of Neonatal Medicine, Hospital of Le Mans, Le Mans, France.
authors.forename: Yannis
authors.initials: Y
authors.lastname: Montcho
authors.affiliation: Laboratoire d'Explorations Fonctionnelles, Nantes University, Centre de Référence Maladies Neuromusculaires Nantes-Angers, University Hospital of Nantes, Nantes, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Péréon
authors.affiliation: Department of Neonatal Medicine, University Hospital of Nantes, Nantes University, Nantes, France 'Loire Infant Follow-up Team' (LIFT) Network, Nantes, Pays de Loire, France Clinical Research Center, INSERM CIC004, University Hospital of Nantes, Nantes, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Flamant
authors.affiliation: 'Loire Infant Follow-up Team' (LIFT) Network, Nantes, Pays de Loire, France Department of Pediatric Neurology, Angers University, University Hospital of Angers, Angers, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Nguyen The Tich
mesh_terms: D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000473:pathology; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000453:epidemiology*; D004569:Electroencephalography; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D007969:Leukomalacia, Periventricular / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination; D018570:Risk Assessment; D011795:Surveys and Questionnaires; D014463:Ultrasonography
keywords: Clin Neurophysiology; Neonatology; Neurodevelopment