title: Creation and study of triterpenoid nanoparticles and radioprotective substance genistein.
abstract: This work is devoted to the study and obtaining of new radioprotective agents based on natural flavonoid genistein and spherical amorphous nanoparticles (SANPs) produced from a mixture of birch bark triterpenoids. The physicochemical characteristics of the nanoparticles were studied by electron microscopy, dynamic light scattering, and UV-VIS spectroscopy. The radioprotective efficacy of the nanodrug in vivo and the possibility of its use as a radioprotective agent was shown.
authors.affiliation: Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117571, Russia. anpha2004@yahoo.com.
authors.forename: H Q
authors.initials: HQ
authors.lastname: Nguyen
authors.affiliation: Moscow Institute of Physics and Technology (State University), Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Chupin
authors.affiliation: Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117571, Russia. prokhor-chembio@yandex.ru.
authors.forename: D I
authors.initials: DI
authors.lastname: Prokhorov
authors.affiliation: Federal State Unitary Enterprise Research and Production Center "Farmzashchita," Federal Biomedical Agency, Khimki, Moscow oblast, 141402, Russia.
authors.forename: I E
authors.initials: IE
authors.lastname: Chikunov
authors.affiliation: Federal State Unitary Enterprise Research and Production Center "Farmzashchita," Federal Biomedical Agency, Khimki, Moscow oblast, 141402, Russia.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Kovtun
authors.affiliation: Military Medical Academy, St. Petersburg, 194044, Russia.
authors.forename: R A
authors.initials: RA
authors.lastname: Tarumov
authors.affiliation: Military Medical Academy, St. Petersburg, 194044, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Grebenyuk
authors.affiliation: Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117571, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Shvets
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D029662:Betula / Q000737:chemistry; D002788:Cholesterol Esters / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D019833:Genistein / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D010316:Particle Size; D053978:Pentacyclic Triterpenes / Q000737:chemistry; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D028321:Plant Preparations / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000188:drug therapy; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011897:Random Allocation; D016019:Survival Analysis; D016896:Treatment Outcome; D014315:Triterpenes / Q000737:chemistry; D000094062:Betulinic Acid; D000094042:Lupanes
chemical_list: D002788:Cholesterol Esters; D019833:Genistein; D053978:Pentacyclic Triterpenes; D028321:Plant Preparations; D011837:Radiation-Protective Agents; D014315:Triterpenes; C002503:betulin; D000094062:Betulinic Acid; C010480:lupeol; D000094042:Lupanes; C013440:cholesteryl succinate