title: Target-triggered cascade recycling amplification for label-free detection of microRNA and molecular logic operations.
abstract: A cascade recycling amplification (CRA) that implements cascade logic circuits with feedback amplification function is developed for label-free chemiluminescence detection of microRNA-122 with an ultrahigh sensitivity of 0.82 fM and excellent specificity, which is applied to construct a series of molecular-scale two-input logic gates by using microRNAs as inputs and CRA products as outputs.
authors.affiliation: College of Chemical Science and Engineering, Laboratory of Fiber Materials and Modern Textiles, the Growing Base for State Key Laboratory, Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao University, Qingdao 266071, P. R. China. bisai11@126.com.
authors.forename: Sai
authors.initials: S
authors.lastname: Bi
authors.forename: Jiayan
authors.initials: J
authors.lastname: Ye
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.forename: Haoting
authors.initials: H
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D039301:Computers, Molecular; D004247:DNA / Q000138:chemical synthesis; D004256:DNA Polymerase I / Q000737:chemistry; D021881:DNA, Catalytic / Q000138:chemical synthesis; D004591:Electrophoresis, Polyacrylamide Gel; D004720:Endonucleases / Q000737:chemistry; D055029:Inverted Repeat Sequences; D035683:MicroRNAs / Q000032:analysis*; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D009693:Nucleic Acid Hybridization
chemical_list: D021881:DNA, Catalytic; D035683:MicroRNAs; D004247:DNA; D004256:DNA Polymerase I; D004720:Endonucleases