title: Long noncoding RNAs in T lymphocytes.
abstract: Long noncoding RNAs are recently discovered regulatory RNA molecules that do not code for proteins but influence a vast array of biologic processes. In vertebrates, the number of long noncoding RNA genes is thought to greatly exceed the number of protein-coding genes. It is also thought that long noncoding RNAs drive the biologic complexity observed in vertebrates compared with that in invertebrates. Evidence of this complexity has been found in the T-lymphocyte compartment of the adaptive immune system. In the present review, we describe our current level of understanding of the expression of specific long or large intergenic or intervening long noncoding RNAs during T-lymphocyte development in the thymus and differentiation in the periphery and highlight the mechanisms of action that specific long noncoding RNAs employ to regulate T-lymphocyte function, both in vitro and in vivo.
authors.affiliation: Departments of *Medicine and Mathematics, Vanderbilt University, Nashville, Tennessee, USA tom.aune@vanderbilt.edu.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Aune
authors.affiliation: Departments of *Medicine and Mathematics, Vanderbilt University, Nashville, Tennessee, USA.
authors.forename: Phillip S
authors.initials: PS
authors.lastname: Crooke
authors.affiliation: Departments of *Medicine and Mathematics, Vanderbilt University, Nashville, Tennessee, USA.
authors.forename: Charles F
authors.initials: CF
authors.lastname: Spurlock
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation; D019070:Cell Lineage; D019295:Computational Biology; D005786:Gene Expression Regulation; D055106:Genome-Wide Association Study; D006801:Humans; D007109:Immunity / Q000235:genetics; D009928:Organ Specificity / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics*; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*
chemical_list: D062085:RNA, Long Noncoding
keywords: adaptive immunity; epigenetics; lncRNA