title: Utility of γ-Glutamyl Transferase in Predicting Troponin Elevation in Emergency Departments.
abstract: Serum γ-glutamyl transferase (GGT) activity is a risk predictor for the development of coronary artery disease and is related to cardiovascular morbidity and mortality. We evaluated the clinical utility of GGT activity in predicting high troponin levels in patients with acute coronary syndrome (ACS) admitted to the emergency department with chest pain. A total of 200 troponin-positive and 203 troponin-negative patients were classified into groups 1 and 2, respectively. γ-Glutamyl transferase activity was significantly higher in group 1 (44 ± 34 U/L) compared with group 2 (31 ± 26 U/L, P = .001). A GGT activity cutoff >25.5 showed 62% sensitivity and 61% specificity in predicting troponin positivity. Logistic regression analysis demonstrated a significant predictive value of GGT for troponin positivity. Spearman rank correlation analysis showed a moderately strong relationship between GGT activity and troponin positivity. Considering the predictive value of high GGT activity for troponin positivity, GGT activity may complement other diagnostic biomarkers for predicting troponin positivity in patients having ACS admitted with chest pain.
authors.affiliation: Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey demirelli23@yahoo.com.
authors.forename: Selami
authors.initials: S
authors.lastname: Demirelli
authors.affiliation: Department of Cardiology, Maresal Cakmak Military Hospital, Erzurum, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Firtina
authors.affiliation: Department of Cardiology, Palandöken State Hospital, Erzurum, Turkey.
authors.forename: Lutfu
authors.initials: L
authors.lastname: Askin
authors.affiliation: Department of Emergency Medicine, Erzurum Education and Research Hospital, Erzurum, Turkey.
authors.forename: Sultan Tuna
authors.initials: ST
authors.lastname: Akgol Gur
authors.affiliation: Department of Emergency Medicine, Erzurum Education and Research Hospital, Erzurum, Turkey.
authors.forename: Ceren Sen
authors.initials: CS
authors.lastname: Tanrikulu
authors.affiliation: Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Ermis
authors.affiliation: Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Ipek
authors.affiliation: Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey.
authors.forename: Kamuran
authors.initials: K
authors.lastname: Kalkan
authors.affiliation: Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Yildirim
authors.affiliation: Department of Biochemistry, Ataturk University Medicine Faculty, Erzurum, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kiziltunc
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D004796:Clinical Enzyme Tests; D003430:Cross-Sectional Studies; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D015203:Reproducibility of Results; D012307:Risk Factors; D014336:Troponin / Q000097:blood*; D015854:Up-Regulation; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D014336:Troponin; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human
keywords: chest pain; emergency department; troponin; γ-glutamyl transferase