title: Familial Churg-Strauss Syndrome in a Sister and Brother.
abstract: Churg-Strauss syndrome (CSS) is a granulomatous small vessel vasculitis. It is characterized by asthma, allergic granulomatosis and vasculitis. This syndrome is rare in children. A 5 years old boy was admitted with cough, fever and dyspnea for 2 weeks. On the basis of laboratory data (peripheral eosinophilia), associated with skin biopsy, and history of CSS in his sister, this disease was eventually diagnosed. The patient had good response to corticosteroid. In every asthmatic patient with prolonged fever, eosinophilia and multisystemic involvment, CSS should be considered.
authors.affiliation: Department of Allergy and Clinical Immunology, Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Soheyla
authors.initials: S
authors.lastname: Alyasin
authors.affiliation: Department of Allergy and Clinical Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Khoshkhui
authors.affiliation: Department of Allergy and Clinical Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Amin
mesh_terms: D002675:Child, Preschool; D015267:Churg-Strauss Syndrome / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D035781:Siblings
keywords: Children; Churg-Strauss syndrome; Vasculitis