title: Relationship Between Urinary Cross-Linked N-Telopeptide of Type-I Collagen and Heel Stiffness Index Measured by Quantitative Ultrasound in Middle-Aged and Elderly Men.
abstract: The aim of the present study was to investigate the age-related patterns and the relationship between levels of urinary cross-linked N-telopeptide of type-I collagen (NTx) and heel stiffness index measured by quantitative ultrasound (QUS) in men with a special reference to age groups of aged 40 to 59 years and ≥60 years.A total of 379 men participated in this study. Heel stiffness index (bone mass) was measured by QUS. Spot urine samples were collected, and urinary NTx was measured. The values were corrected for creatinine (Cre) concentration.Stiffness index was significantly lower in men aged ≥60 years compared with men aged 40 to 59 years (P < 0.0001). There was no significant difference of Log (NTx/Cre) by 10-year age groups. Multiple regression analysis showed that higher level of urinary NTx/Cre was significantly correlated with lower stiffness index after adjusting for age and body mass index in men aged ≥60 years, but not in men aged 40 to 59 years.Higher rates of bone resorption were associated with lower stiffness index only in elderly men. Our results may indicate a different mechanism of low bone mass among different age groups.
authors.affiliation: From the Department of Public Health (TN, KA, YA, TO, YT, KA), Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rehabilitation (MK, SM, TO, YT), Nishi-Isahaya Hospital, Isahaya; Goto Health Care Office (HG), Nagasaki; and Center for Public Relations Strategy (IH), Nagasaki University, Nagasaki, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nishimura
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Arima
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Abe
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kanagae
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizukami
authors.forename: Takuhiro
authors.initials: T
authors.lastname: Okabe
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Tomita
authors.forename: Hisashi
authors.initials: H
authors.lastname: Goto
authors.forename: Itsuko
authors.initials: I
authors.lastname: Horiguchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Aoyagi
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000652:urine; D015992:Body Mass Index; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000652:urine*; D024042:Collagen Type I / Q000652:urine*; D006365:Heel / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000652:urine*; D012189:Retrospective Studies; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide