title: [Roles of Tumor-infiltrating Lymphocytes in Non-small Cell Lung Cancer Recurrence and Metastasis:A Meta Analysis].
abstract: OBJECTIVE
  To determine the prognostic value of tumor-infiltrating lymphocytes in the recurrence and metastasis of non-small cell lung cancer (NSCLC).
  
  
  METHODS
  A PubMed, EMBASE, Cochrane Library databases, NIH databases, and China Biology Medicine disc, China National Knowledge Infrastructure, Chinese Science and Technology Periodical literature search strategy was designed. Studies on the prognostic values of intratumoural CD3⁺,CD4⁺,CD8⁺, and FoxP3+lymphocytes for NSLCL were retrieved. RevMan 5.1 was applied for Meta analysis.
  
  
  RESULTS
  Totally 8 studies entered the final analysis. In pooled analysis of 1197 patients,the high expressions of CD3⁺ and CD8⁺ cells were correlated with the increase of overall survival (OS) (OR=0.52,95% CI=0.40- 0.68, P<0.0001; OR=0.52,95% CI=0.34-0.79,P=0.002), and the high expression of CD8⁺ was significantly correlated with the increase of disease-free survival (DFS) (OR=0.68,95% CI=0.51-0.91,P=0.01). The CD4⁺ cell expression level was not significantly correlated with OS or DFS (P=0.14, P=0.73). The high expression of FoxP3⁺ cells did not favor the DFS(OR=1.78,95% CI=1.36-2.31; P<0.0001).
  
  
  CONCLUSIONS
  The expression levels of CD3⁺, CD8⁺ and FoxP3⁺ in NSCLC microenviroment are related with the prognosis of NSCLC, while the role of CD4⁺ in the development of NSCLC warrants further investigations.
authors.affiliation: Department of Oncology,Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Oncology,Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Shun-chang
authors.initials: SC
authors.lastname: Jiao
mesh_terms: D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D002289:Carcinoma, Non-Small-Cell Lung; D002681:China; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms; D016246:Lymphocytes, Tumor-Infiltrating; D009362:Neoplasm Metastasis; D011379:Prognosis; D012008:Recurrence