title: Therapeutic drug monitoring: A patient management tool for precision medicine.
abstract: The precision medicine initiative is designed to better understand the causes of disease, to develop target therapies, and to identify patients that would benefit from treatment. Prescribing the right dose, which is not always the same to all patients, is needed for a successful outcome. The purpose of this commentary is to discuss the role of dose individualization based on therapeutic drug monitoring as a clinical patient management tool in the application of precision medicine.
authors.affiliation: Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Jang
authors.affiliation: Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Lazor
mesh_terms: D019468:Disease Management; D016903:Drug Monitoring / Q000379:methods* / Q000639:trends; D011307:Drug Prescriptions; D006801:Humans; D010346:Patient Care Management / Q000379:methods* / Q000639:trends; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D057285:Precision Medicine; D016896:Treatment Outcome
chemical_list: D004364:Pharmaceutical Preparations