title: An electromechanical left ventricular wedge model to study the effects of deformation on repolarization during heart failure.
abstract: Heart failure is a major and costly problem in public health, which, in certain cases, may lead to death. The failing heart undergo a series of electrical and structural changes that provide the underlying basis for disturbances like arrhythmias. Computer models of coupled electrical and mechanical activities of the heart can be used to advance our understanding of the complex feedback mechanisms involved. In this context, there is a lack of studies that consider heart failure remodeling using strongly coupled electromechanics. We present a strongly coupled electromechanical model to study the effects of deformation on a human left ventricle wedge considering normal and hypertrophic heart failure conditions. We demonstrate through a series of simulations that when a strongly coupled electromechanical model is used, deformation results in the thickening of the ventricular wall that in turn increases transmural dispersion of repolarization. These effects were analyzed in both normal and failing heart conditions. We also present transmural electrograms obtained from these simulations. Our results suggest that the waveform of electrograms, particularly the T-wave, is influenced by cardiac contraction on both normal and pathological conditions.
authors.affiliation: Graduate Program on Computational Modeling, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil.
authors.forename: B M
authors.initials: BM
authors.lastname: Rocha
authors.affiliation: Graduate Program on Computational Modeling, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil ; National Laboratory of Scientific Computing, 25651-075 Petrópolis, RJ, Brazil.
authors.forename: E M
authors.initials: EM
authors.lastname: Toledo
authors.affiliation: Graduate Program on Computational Modeling, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil.
authors.forename: L P S
authors.initials: LP
authors.lastname: Barra
authors.affiliation: Graduate Program on Computational Modeling, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil.
authors.forename: R Weber
authors.initials: RW
authors.lastname: dos Santos
mesh_terms: D000818:Animals; D003198:Computer Simulation; D055119:Elastic Modulus; D056966:Excitation Contraction Coupling; D006329:Heart Conduction System / Q000503:physiopathology*; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D040542:Mechanotransduction, Cellular; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D013314:Stress, Mechanical; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000503:physiopathology*