title: Klebsiella oxytoca-producing IMP-1 Detected as the First Strain of Carbapenem-resistant Enterobacteriaceae in Our Hospital.
abstract: We herein report a case of Klebsiella oxytoca-producing IMP-1 that was detected as a first isolate of carbapenem-resistant Enterobacteriaceae (CRE) at our facility. Since K. oxytoca is an uncommon strain for CRE, we speculated that the resistant organism had already spread out inside the hospital. Metallo-β-lactamases promotes antibiotic resistance in Enterobacteriaceae, which potentially yields problematic issues in clinical settings. Active surveillance of antibiotic resistant strains is important and should be repeatedly highlighted. Furthermore, appropriate methods should be established to detect highly resistant strains.
authors.affiliation: Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Hagiya
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ogawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Akira
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D003428:Cross Infection / Q000175:diagnosis*; D006761:Hospitals; D006801:Humans; D007291:Inosine Monophosphate / Q000302:isolation & purification*; D007710:Klebsiella Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission; D041121:Klebsiella oxytoca / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007291:Inosine Monophosphate; D001618:beta-Lactamases