title: Prognosis of papillary thyroid cancers with positive serum thyroglobulin antibody after total thyroidectomy.
abstract: OBJECTIVE
  To investigate the influence of serum anti-thyroglobulin antibody (TgAb) on the prognosis in papillary thyroid cancer (PTC) patients.
  
  
  METHODS
  In this retrospective study, the participants were enrolled from 1206 PTC patients (927 women, 279 men; mean age, 42.2 years) with T2 and higher, or N1 or M1 classifications in tumor-node-metastasis staging after total thyroidectomy. We recorded the final serum TgAb data (on thyroxin therapy) at the end of follow-up in 2012. Patients were classified as negative TgAb or positive TgAb groups on the basis of their serum TgAb levels (< 70 IU/mL or ≥ 70 IU/mL).
  
  
  RESULTS
  Among the 1206 patients, after mean follow-up for 11.6 ± 6.1 years (range, 2.0-29.2 years), there were 75 with positive TgAb and 1131 with negative TgAb. Patient categorization depending on the follow-up time (2-5 years after surgery, 5-10 years after surgery, and 10-30 years after surgery) was performed. In comparison to traditional risk factors, such as age, tumor size, and sex, which were important prognostic factors for cancer recurrence and mortality in PTC patients, there was no significant difference in the prognosis between positive TgAb patients and negative TgAb patients by the multivariate analyses (cancer recurrence, p = 0.164, p = 0.112, p = 0.202, respectively; cancer mortality, p = 0.181, p = 0.646, p = 0.656, respectively) based on the different follow-up times.
  
  
  CONCLUSIONS
  Positive serum TgAb was not a risk factor, and was not associated with the prognosis of PTC patients.
authors.affiliation: Department of Endocrinology and Metabolism, Chang Gung Memorial Hospital, Keelung, Taiwan; Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan.
authors.forename: Sheng-Fong
authors.initials: SF
authors.lastname: Kuo
authors.affiliation: Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan; Department of General Surgery, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan.
authors.forename: Tzu-Chieh
authors.initials: TC
authors.lastname: Chao
authors.affiliation: Department of Endocrinology and Metabolism, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan.
authors.forename: Hung-Yu
authors.initials: HY
authors.lastname: Chang
authors.affiliation: Department of Pathology, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan.
authors.forename: Chuen
authors.initials: C
authors.lastname: Hsueh
authors.affiliation: Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan; Department of Gastroenterology, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Chih-Lang
authors.initials: CL
authors.lastname: Lin
authors.affiliation: Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan; Department of General Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Kun-Chun
authors.initials: KC
authors.lastname: Chiang
authors.affiliation: Department of Pathology, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Chuang
authors.affiliation: Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Yung-Chih
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan; Department of Endocrinology and Metabolism, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan. Electronic address: einjd@adm.cgmh.org.tw.
authors.forename: Jen-Der
authors.initials: JD
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D002291:Carcinoma, Papillary / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D013965:Thyroidectomy; D055815:Young Adult
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin
keywords: anti-thyroglobulin antibody; mortality; recurrence; total thyroidectomy