title: [Expression and significance of adhesion molecules CD62P and CD44 in peripheral blood of infants with bronchiolitis].
abstract: OBJECTIVE
  To explore the expression and significance of the adhesion molecules CD62P and CD44 in the peripheral blood of infants with bronchiolitis.
  
  
  METHODS
  Thirty-three infants with bronchiolitis in the acute phase and 19 infants with bronchiolitis in the recovery phase, who were hospitalized between November 2014 and May 2015, were enrolled. Thirty infants with bronchopneumonia and 26 infants without infection were enrolled as the bronchopneumonia group and the control group, respectively. The CD62P expression in the peripheral blood of each group was measured by flow cytometry, and the CD44 level in serum was determined using ELISA.
  
  
  RESULTS
  The levels of the adhesion molecules CD62P and CD44 in the bronchiolitis group in the acute phase were significantly higher than those in the bronchiolitis group in the recovery phase, the bronchopneumonia group, and the control group (P<0.05). The levels of the adhesion molecules CD62P and CD44 in the bronchiolitis group in the recovery phase were also significantly higher than those in the control group (P<0.05). In the bronchiolitis group in the acute phase, there was a positive correlation between CD62P expression and serum CD44 level (r=0.91; P<0.05).
  
  
  CONCLUSIONS
  The adhesion molecules CD62P and CD44 play an important role in the pathogenesis of bronchiolitis, and their levels can reflect the severity of inflammatory response in infants with bronchiolitis.
authors.affiliation: Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. wanzlpzlpz@163.com.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zou
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D001988:Bronchiolitis / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000097:blood / Q000502:physiology*; D007223:Infant; D008297:Male; D019007:P-Selectin / Q000097:blood / Q000502:physiology*
chemical_list: C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D019007:P-Selectin; C546937:SELP protein, human