title: Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults.
abstract: BACKGROUND
  We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults.
  
  
  METHODS
  Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12months postoperatively.
  
  
  RESULTS
  Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12months in non-DM group, while improving significantly at 6 and 12months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12months in non-DM group and 12months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12months postoperatively without significant changes in CRP and IL-6.
  
  
  CONCLUSIONS
  Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Taipei-Veteran General Hospital, Taipei, Taiwan; Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address: shihkc@totalbb.net.tw.
authors.forename: Kuang-Chung
authors.initials: KC
authors.lastname: Shih
authors.affiliation: Special Hematology Laboratory, Department of Hematology, Veterans Affairs Medical Center, Louisville, KY, USA; Department of Microbiology and Immunology, University of Louisville, School of Medicine, Louisville, KY, USA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Janckila
authors.affiliation: Department of surgery, Ming-Sheng General Hospital, National Taiwan University, Tauoyan, Taiwan.
authors.forename: Wei-Jei
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Chou
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Taipei-Veteran General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chun-Jui
authors.initials: CJ
authors.lastname: Huang
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Taipei-Veteran General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Ching-Fai
authors.initials: CF
authors.lastname: Kwok
authors.affiliation: Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Low-Tone
authors.initials: LT
authors.lastname: Ho
authors.affiliation: Division of Hematology/Oncology, Shuang-Ho Hospital and Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Tsu-Yi
authors.initials: TY
authors.lastname: Chao
mesh_terms: D000135:Acid Phosphatase / Q000097:blood*; D000328:Adult; D044466:Asian People; D050110:Bariatric Surgery; D001786:Blood Glucose / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance; D007527:Isoenzymes / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D000071681:Tartrate-Resistant Acid Phosphatase; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D007527:Isoenzymes; D008055:Lipids; D002097:C-Reactive Protein; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase
keywords: Bariatric surgery; Diabetes mellitus; Inflammatory cytokine; Insulin resistance; Metabolic syndrome; Tartrate-resistant acid phosphatase 5a