title: Biodegradable-Polymer-Blend-Based Surgical Sealant with Body-Temperature-Mediated Adhesion.
abstract: The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer-substrate interfacial interactions leading to improved adhesion and surgical sealant performance.
authors.affiliation: Fischell Department of Bioengineering, 2330 Jeong H. Kim Engineering Building, University of Maryland, College Park, MD, 20742, USA.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Behrens
authors.affiliation: Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Center, 111 Michigan Avenue, NW Washington, DC, 20010, USA.
authors.forename: Nora G
authors.initials: NG
authors.lastname: Lee
authors.affiliation: Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology Chemistry and Materials Science, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
authors.forename: Brendan J
authors.initials: BJ
authors.lastname: Casey
authors.affiliation: Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Center, 111 Michigan Avenue, NW Washington, DC, 20010, USA.
authors.forename: Priya
authors.initials: P
authors.lastname: Srinivasan
authors.affiliation: Fischell Department of Bioengineering, 2330 Jeong H. Kim Engineering Building, University of Maryland, College Park, MD, 20742, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sikorski
authors.affiliation: Fischell Department of Bioengineering, 2330 Jeong H. Kim Engineering Building, University of Maryland, College Park, MD, 20742, USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Daristotle
authors.affiliation: Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Center, 111 Michigan Avenue, NW Washington, DC, 20010, USA.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Sandler
authors.affiliation: Fischell Department of Bioengineering, 2330 Jeong H. Kim Engineering Building, University of Maryland, College Park, MD, 20742, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Kofinas
mesh_terms: D000269:Adhesives / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001831:Body Temperature; D019344:Lactic Acid / Q000737:chemistry; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013523:Surgical Equipment
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols
keywords: biodegradable polymers; solution blow spinning; surgical sealants; temperature responsive