title: Vaccines for Antibiotic-Resistant Bacteria: Possibility or Pipe Dream?
abstract: The increasing incidence of infections caused by antibiotic-resistant bacteria from multiple species, together with the paucity of new antibiotics in the development pipeline, indicates that vaccines could play a role in combating these infections. The development of vaccines for these infections presents unique challenges related to target population selection, vaccine administration, and antigen identification. Advances in genomic, transcriptomic, and proteomic technologies offer great potential for identifying promising antigens that are highly conserved and expressed during human infections. Although important challenges remain, the potential health and economic benefits associated with the clinical implementation of vaccination strategies for the prevention of antibiotic-resistant infections warrant their continued development.
authors.affiliation: Biomedical Institute of Seville/University Hospital Virgen del Rocío, Seville, Spain.
authors.forename: Meritxell
authors.initials: M
authors.lastname: García-Quintanilla
authors.affiliation: Biomedical Institute of Seville/University Hospital Virgen del Rocío, Seville, Spain.
authors.forename: Marina R
authors.initials: MR
authors.lastname: Pulido
authors.affiliation: Biomedical Institute of Seville/University Hospital Virgen del Rocío, Seville, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Carretero-Ledesma
authors.affiliation: Biomedical Institute of Seville/University Hospital Virgen del Rocío, Seville, Spain. Electronic address: mcconnell.mike75@gmail.com.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: McConnell
mesh_terms: D001424:Bacterial Infections / Q000382:microbiology* / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans
chemical_list: D001428:Bacterial Vaccines
keywords: antibiotic resistance; antigen identification; clinical trials; passive immunization; vaccine