title: The role of imaging in the diagnosis and management of hypertrophic cardiomyopathy.
abstract: Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy, affecting approximately 1:500 people. As the yield of genetic testing is only about 35-60%, the diagnosis of HCM is still clinical and based on the demonstration of unexplained and usually asymmetric left ventricular (LV) hypertrophy by imaging modalities. In the past, echocardiography was the sole imaging modality used for the diagnosis and management of HCM. However, in recent years other imaging modalities such as cardiac magnetic resonance have played a major role in the diagnosis, management and risk stratification of HCM, particularly when the location of left ventricular hypertrophy is atypical (apex, lateral wall) and when the echocardiographic imaging is sub-optimal. However, the most unique contribution of cardiac magnetic resonance is the quantification of myocardial fibrosis. Exercise stress echocardiography is the preferred provocative test for the assessment of LV outflow tract obstruction, which is detected only on provocation in one-third of the patients.
authors.affiliation: a Department of Cardiology , Toronto General Hospital , Toronto , Canada.
authors.forename: Adaya
authors.initials: A
authors.lastname: Weissler-Snir
authors.affiliation: a Department of Cardiology , Toronto General Hospital , Toronto , Canada.
authors.forename: Andrew
authors.initials: A
authors.lastname: Crean
authors.affiliation: a Department of Cardiology , Toronto General Hospital , Toronto , Canada.
authors.forename: Harry
authors.initials: H
authors.lastname: Rakowski
mesh_terms: D057791:Cardiac Imaging Techniques / Q000379:methods*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000151:congenital / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D019468:Disease Management; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D018570:Risk Assessment
keywords: cardiac computed tomography; cardiac magnetic resonance; echocardiography; hypertrophic cardiomyopathy; left ventricular hypertrophy; left ventricular outflow obstruction; sudden cardiac death