title: Aryl hydrocarbon receptor: Linking environment to immunity.
abstract: Mucosal and barrier tissues are unique in that they mediate crosstalk between the host and the surrounding environment, which contains many potentially harmful factors. Therefore, it is critical that cell types present at barrier and mucosal surfaces are equipped with mechanisms to sense changes in the environment and to calibrate their responses accordingly. Aryl Hydrocarbon Receptor (AHR) is a ligand dependent transcription factor well known to generate biological responses to environmental pollutants, such as benzo{a}pyrene and halogenated dioxins. Surprisingly, in the last few years a large body of evidence has shown that AHR is also involved in maintaining homeostasis or in triggering pathology by modulating the biological responses of critical cell types at the barrier and mucosal interfaces. Here, we will review progresses in this field and discuss how targeting AHR activation may impact disease.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, United States. Electronic address: mcella@pathology.wustl.edu.
authors.forename: Marina
authors.initials: M
authors.lastname: Cella
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, United States. Electronic address: mcolonna@pathology.wustl.edu.
authors.forename: Marco
authors.initials: M
authors.lastname: Colonna
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D004777:Environment; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000378:metabolism; D007109:Immunity; D007113:Immunity, Innate; D008024:Ligands; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D009928:Organ Specificity / Q000235:genetics; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D018336:Receptors, Aryl Hydrocarbon
keywords: Aryl hydrocarbon receptor; IL-22; Innate lymphoid cells; Mucosal tissues