title: [Treatment of hepatitis C before and after liver transplantation].
abstract: Hepatitis C recurrence after liver transplantation is universal and increases morbidity and mortality in these patients. The development of new direct antiviral agents against the hepatitis C virus is a major treatment advance. Pre-transplant treatment avoids graft infection and sometimes improves liver function, allowing the patient to be withdrawn from the transplant waiting list. Delaying treatment until the postpostransplant period may be advisable in patients with advanced cirrhosis. Generally, antiviral therapy after liver transplantation is provided in patients with histological evidence of the disease. In these patients, treatment is more effective in the initial stages of the disease. The choice of antiviral therapy in these patients is based on the degree of liver function, the presence of renal failure, and potential drug-drug interactions.
authors.affiliation: Servicio de Hepatología, Hospital Clínic Barcelona, CIBEREHD, IDIBAPS, Barcelona, España.
authors.forename: Laura-Patricia
authors.initials: LP
authors.lastname: Llovet
authors.affiliation: Servicio de Hepatología, Hospital Clínic Barcelona, CIBEREHD, IDIBAPS, Barcelona, España.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rodríguez-Tajes
authors.affiliation: Servicio de Hepatología, Hospital Clínic Barcelona, CIBEREHD, IDIBAPS, Barcelona, España. Electronic address: mlondono@clinic.ub.es.
authors.forename: María-Carlota
authors.initials: MC
authors.lastname: Londoño
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D016174:Hepacivirus; D006526:Hepatitis C / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation
chemical_list: D000998:Antiviral Agents
keywords: Antivirales directos; Direct antiviral agents; Hepatitis C; Liver transplantation; Trasplante hepático