title: Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors.
abstract: Since 2001, brachial-ankle pulse wave velocity (brachial-ankle PWV) measurement has been applied for risk stratification of patients with atherosclerotic cardiovascular disease and/or its risk factors in Japan. Measurement of the brachial-ankle PWV is simple and well standardized, and its reproducibility and accuracy are acceptable. Several cross-sectional studies have demonstrated a significant correlation between the brachial-ankle PWV and known risk factors for cardiovascular disease; the correlation is stronger in subjects with cardiovascular disease than in those without cardiovascular disease. We conducted a meta-analysis, which demonstrated that the brachial-ankle PWV is an independent predictor of future cardiovascular events. Furthermore, the treatment of cardiovascular risk factors and lifestyle modifications have been shown to improve the brachial-ankle PWV. Thus, at present, brachial-ankle PWV is close to being considered as a useful marker in the management of atherosclerotic cardiovascular disease and/or its risk factors.
authors.affiliation: Department of Cardiology, Tokyo Medical University.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tomiyama
authors.forename: Chisa
authors.initials: C
authors.lastname: Matsumoto
authors.forename: Kazuki
authors.initials: K
authors.lastname: Shiina
authors.forename: Akira
authors.initials: A
authors.lastname: Yamashina
mesh_terms: D055109:Ankle Brachial Index; D015415:Biomarkers / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D019468:Disease Management; D006801:Humans; D063177:Pulse Wave Analysis; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers