title: Isopropylmagnesium chloride-promoted unilateral addition of Grignard reagents to β-diketones: one-pot syntheses of β-tertiary hydroxyl ketones or 3-substituted cyclic-2-enones.
abstract: The regioselective unilateral additions of Grignard reagents to acyclic or cyclic β-diketones were effectively promoted by sub-stoichiometric amounts of i-PrMgCl to afford β-tertiary hydroxyl ketones or 3-substituted cyclic-2-enones, respectively. Also, the addition of Grignard reagents to acyclic β-diketones followed by a reaction with cyclic β-diketones in a one-pot process was put forward. The reaction mechanism was discussed in detail to explain the high regioselectivity via chemical experiments, hydrogen-deuterium exchange and mass spectrometry.
authors.affiliation: Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China. dachaoshan@lzu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Yuan
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Pan
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.forename: Hong-Feng
authors.initials: HF
authors.lastname: Li
authors.forename: Chao-Shan
authors.initials: CS
authors.lastname: Da