title: Effect of nutritional status and dietary patterns on human serum C-reactive protein and interleukin-6 concentrations.
abstract: The inflammatory process plays an important role in the pathogenesis of many chronic diseases, such as cardiovascular diseases, diabetes mellitus type 2, and metabolic syndrome. Serum C-reactive protein (CRP) and interleukin-6 (IL-6) are widely tested inflammatory markers involved in the development of these diseases. Several studies indicate a relation between nutritional status and the concentrations of human high-sensitivity CRP and IL-6. Similarly, the role of diet in reducing inflammation and thereby modulating the risk of non-communicable diseases is supported by numerous studies. This review focuses on the effects of the selected nutrition models in humans on the concentrations of CRP and IL-6. It seems that the Mediterranean diet model is most effective in inhibiting inflammation. The Dietary Approaches to Stop Hypertension model and the plant nutrition model also have proven to be beneficial. The data on low-fat and low-carbohydrate diets are inconclusive. Comprehensive studies are necessary, taking into account the cumulative effect of dietary and other factors on the inflammatory process.
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznan, Poland angelika.smidowicz@up.poznan.pl.
authors.forename: Angelika
authors.identifier: http://orcid.org/0000-0001-6945-6004
authors.initials: A
authors.lastname: Smidowicz
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznan, Poland.
authors.forename: Julita
authors.identifier: http://orcid.org/0000-0002-3265-547X
authors.initials: J
authors.lastname: Regula
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D004032:Diet; D050528:Diet, Carbohydrate-Restricted; D018752:Diet, Fat-Restricted; D038441:Diet, Mediterranean; D015444:Exercise; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D007249:Inflammation / Q000097:blood* / Q000517:prevention & control; D015850:Interleukin-6 / Q000097:blood*; D016239:MEDLINE; D008297:Male; D008875:Middle Aged; D009316:National Institutes of Health (U.S.); D009752:Nutritional Status / Q000502:physiology*; D014481:United States
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein
keywords: DASH diet; Mediterranean diet; inflammation; inflammatory markers; nutrition model