title: Role of topology in complex functional networks of beta cells.
abstract: The activity of pancreatic β cells can be described by biological networks of coupled nonlinear oscillators that, via electrochemical synchronization, release insulin in response to augmented glucose levels. In this work, we analyze the emergent behavior of regular and percolated β-cells clusters through a stochastic mathematical model where "functional" networks arise. We show that the emergence and robustness of the synchronized dynamics depend both on intrinsic and extrinsic parameters. In particular, cellular noise level, glucose concentration, network spatial architecture, and cell-to-cell coupling strength are the key factors for the generation of a rhythmic and robust activity. Their role in the functional network topology associated with β-cells clusters is analyzed and discussed.
authors.affiliation: Nonlinear Physics and Mathematical Modeling Laboratory, University Campus Bio-Medico of Rome, I-00128, Rome, Italy.|International Center for Relativistic Astrophysics Network-I.C.R.A.Net, University Campus Bio-Medico of Rome, I-00128, Rome, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Cherubini
authors.affiliation: Nonlinear Physics and Mathematical Modeling Laboratory, University Campus Bio-Medico of Rome, I-00128, Rome, Italy.|International Center for Relativistic Astrophysics Network-I.C.R.A.Net, University Campus Bio-Medico of Rome, I-00128, Rome, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Filippi
authors.affiliation: Nonlinear Physics and Mathematical Modeling Laboratory, University Campus Bio-Medico of Rome, I-00128, Rome, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Gizzi
authors.affiliation: Nonlinear Physics and Mathematical Modeling Laboratory, University Campus Bio-Medico of Rome, I-00128, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Loppini
mesh_terms: D000818:Animals; D003198:Computer Simulation; D017629:Gap Junctions / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D010507:Periodicity; D013269:Stochastic Processes
chemical_list: D005947:Glucose