title: Immunotherapeutic Biologic Agents in Autoimmune and Autoinflammatory Diseases.
abstract: In recent decades, innovative strategies to treat patients with inflammatory, immunologically based diseases have advanced in concert with our increased understanding of molecular immunology. Recognition of the spectrum and pathophysiology of autoimmune and autoinflammatory disorders has allowed for the development of cutting-edge therapies for such patients. In this review, key immunotherapeutic approaches for treating inflammatory autoimmune disorders, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as well as genetic autoinflammatory diseases, such as cryopyrin associated periodic syndromes, are addressed. Indications, risks and additional considerations in the use of these agents are reviewed.
authors.affiliation: a Department of Pediatrics , Pediatric Rheumatology and Rheumatology, Pediatrician-in-Chief of Penn State Hershey Children's Hospital , Hershey , PA , USA.
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Ostrov
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D001685:Biological Factors / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy; D007249:Inflammation / Q000276:immunology / Q000628:therapy*
chemical_list: D001685:Biological Factors
keywords: Autoimmune diseases; autoinflammatory diseases; biologic therapy; immunotherapy