title: Do Left- and Right-Handed People Have Similar Iron Deposition in the Basal Ganglia?
abstract: OBJECTIVE
  This study aimed to investigate whether right-, left-, or mixed-handed people differ in terms of iron deposition using susceptibility weighted imaging in healthy subjects.
  
  
  METHODS
  A total of 87 people (right-handed, 51 subjects; left-handed, 19 subjects; mixed-handed, 17 subjects) aged 20 to 40 years participated. All underwent magnetic resonance examination, including conventional and susceptibility weighted imaging sequences. Phase images were used to quantify iron deposition in the head of the caudate nucleus and lenticular nucleus. The radian angle value was calculated and compared between the 3 (right-, left-, or mixed-handed) groups.
  
  
  RESULTS
  There was no significant difference in the radian angle values between left-, right-, or mixed-handed people for either the right or left side of the caudate nucleus head. However, the amount of iron deposition in the left lenticular nucleus was significantly higher for right-handed than for the left-handed subjects (P < 0.001) and significantly higher for mixed-handed than for left-handed subjects (P = 0.006). In addition, the amount of iron deposition in the right lenticular nucleus was significantly lower for left-handed than for right-handed subjects (P < 0.001).
  
  
  CONCLUSIONS
  The results revealed no significant differences in iron deposition in the head of the caudate nucleus. However, there was a significant difference in iron deposition in the lenticular nucleus between left- and right-handed subjects and between left- and mixed-handed subjects.
authors.affiliation: From the *Institute of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University; and †Philips Research China, Philips Innovation Campus, Shanghai, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Li
authors.forename: He
authors.initials: H
authors.lastname: Wang
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D055815:Young Adult
chemical_list: D007501:Iron