title: Effect of Sodium Hyaluronate on Recovery after Arthroscopic Knee Surgery.
abstract: The aim of this study was to evaluate the effect of a single immediate postoperative instillation of 10 mL of sodium hyaluronate (Viscoseal) into the knee following arthroscopy. A single-center, prospective, randomized, controlled study was undertaken. Consenting knee arthroscopy patients were randomized into two groups following surgery: the study group received 10 mL of sodium hyaluronate intra-articularly, while the control group received an intra-articular instillation of 10 mL of Bupivacaine. Pre- and postoperative visual analogue scale scores for pain and Western Ontario and McMaster Universities (WOMAC) scores for knee function were obtained. Overall, 48 patients under the care of a single surgeon were randomized into two groups of 24. There were no statistically significant demographic differences at baseline. Three patients were lost to follow-up. There was a statistically significant difference in pain scores favoring the study group compared with the control group at 3 and 6 weeks postoperatively (p < 0.05), and a statistically significant difference in WOMAC scores favoring the study group compared with the control group at 3 and 6 weeks postoperatively (p = 0.01). Synovial fluid replacement with sodium hyaluronate following arthroscopic knee surgery conferred statistically significant improvements in pain and function scores compared with Bupivacaine in the short term (3-6 weeks).
authors.affiliation: Department of Trauma and Orthopaedics, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Anand
authors.affiliation: Department of Trauma and Orthopaedics, University Hospital of North Tees, Stockton, United Kingdom.
authors.forename: Kiran
authors.initials: K
authors.lastname: Singisetti
authors.affiliation: Department of Trauma and Orthopaedics, Sarathi Superspeciality Orthopaedic Centre, Bangalore, India.
authors.forename: Koppa N
authors.initials: KN
authors.lastname: Srikanth
authors.affiliation: Department of Physiotherapy, The Royal Oldham Hospital, Oldham, United Kingdom.
authors.forename: Cathy
authors.initials: C
authors.lastname: Bamforth
authors.affiliation: Department of Trauma and Orthopaedics, The Royal Oldham Hospital, Oldham, United Kingdom.
authors.forename: Theophilus
authors.initials: T
authors.lastname: Asumu
authors.affiliation: Department of Trauma and Orthopaedics, The Royal Oldham Hospital, Oldham, United Kingdom.
authors.forename: Keyur
authors.initials: K
authors.lastname: Buch
mesh_terms: D000328:Adult; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage; D001182:Arthroscopy; D001672:Biocompatible Materials / Q000008:administration & dosage; D002045:Bupivacaine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D007592:Joint Diseases / Q000601:surgery*; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy / Q000628:therapy*; D011446:Prospective Studies; D020127:Recovery of Function; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D001672:Biocompatible Materials; C509830:Viscoseal; D006820:Hyaluronic Acid; D002045:Bupivacaine