title: Association of homocysteine with type 1 diabetes mellitus: a meta-analysis.
abstract: OBJECTIVE
  To figure out the association between plasma Hcy status and type 1 diabetes mellitus (T1DM).
  
  
  METHODS
  We searched the PubMed Web of Science, and The Cochrane Library to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of selected studies. All analyses were performed using the STATA, version 12 software.
  
  
  RESULTS
  15 studies were included in this investigation. Our meta-analysis indicated that plasma Hcy concentrations in T1DM patients without any complications were normal compared with healthy people [13 studies, SMD: -0.08, 95% confidence interval (CI): -0.44 to 0.28, P=0.67]. However, a significant elevation of plasma Hcy concentrations was observed in T1DM patients with only diabetic retinopathy (DR) (5 studies, SMD: 0.34, 95% CI: 0.13 to 0.55, P=0.002), only diabetic nephropathy (DN) (4 studies, SMD: 0.76, 95% CI: 0.18 to 1.33, P=0.01) and both the two complications (3 studies, SMD: 1.05, 95% CI: 0.03 to 2.07, P=0.043) compared with T1DM patients without any complications.
  
  
  CONCLUSIONS
  Homocysteine levels elevate in T1DM patients with DR and DN, but don't elevate in T1DM without any complications.
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
authors.forename: Mei-Qin
authors.initials: MQ
authors.lastname: Shan
authors.affiliation: Department of Rheumatology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Bo
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Hu
keywords: Homocysteine; diabetic nephropathy; diabetic retinopathy; meta-analysis; type 1 diabetes mellitus