title: Lipoxin A4 ameliorates ischemia/reperfusion induced spinal cord injury in rabbit model.
abstract: Ischemia/reperfusion (I/R) induced spinal cord injury is an important pathologic mechanism leading to the paraplegia observed after surgery to repairaortic aneurysms. This study aims to investigate the neuroprotective effects of Lipoxin A4 and its potential mechanism in a rabbit model with I/R spinal cord injury. Forty-five rabbits were randomly divided into three groups: sham group, I/R group and Lipoxin A4 group. Rabbits were subject to 30 min aortic occlusion to induce transient spinal cord ischemia. All animals were sacrificed after neurological evaluation with modified Tarlov criteria at the 48th hour after reperfusion, and the spinal cord segments (L4-6) were harvested for histopathological examination, as well as local malondialdehyde (MDA) and total superoxide dismutase (SOD) activity analysis. All animals in the I/R group became paraplegic. While after 48-hour treatment, compared with I/R group, Lipoxin A4 significantly improved neurological function, reduced cell apoptosis and MDA levels as well as increased SOD activity (P < 0.05). These results suggest that Lipoxin A4 can ameliorate I/R induced spinal cord injury in Rabbit through its antiapoptosis and antioxidant activity.
authors.affiliation: Jining Medical College Rizhao, Shandong, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: Health Center, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University Jinan, Shandong, China.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Zhang
authors.affiliation: Department of Central Laboratory, Yidu Central Hospital of Weifang City Weifang, Shandong, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University Jinan, Shandong, China.
authors.forename: Li-Jian
authors.initials: LJ
authors.lastname: Xia
authors.affiliation: Department of Endocrinology, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University Jinan, Shandong, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
keywords: Lipoxin A4; ischemia/reperfusion injury; rabbits; spinal cord