title: Prediction of liver injury using the BP-ANN model with metabolic parameters in overweight and obese Chinese subjects.
abstract: Nonalcoholic fatty liver disease (NAFLD) is often associated with dyslipidemia. Metabolic disequilibrium, resulting from being overweight and obesity, increases risk to cardiovascular system and chronic liver disease. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) are standard clinical markers for liver injury. In this study, we examined association of body mass index (BMI) and metabolic markers with serum ALT, AST and GGT activity in an overweight and obese Chinese population. A total of 421 overweight and obese Chinese adults (211 males and 210 females) from The First Affiliated Hospital of Wenzhou Medical University were recruited in this study in 2014. All participants underwent anthropometric measures and phlebotomy after an overnight fast. Elevated ALT, AST and GGT levels were found in 17%, 5% and 24%, respectively. There were significant correlations between ALT and BMI, plasma triglycerides (TG), cholesterol, HDL and glucose, and between AST and plasma TG and cholesterol. GGT also correlated with plasma TG, cholesterol and glucose. The levels of ALT, AST and GGT could be predicted by BMI, plasma TG, cholesterol, HDL and glucose using the back propagation artificial neural network model (BP-ANN). These data suggest that abnormal metabolic markers could be used to monitor liver function to determine whether liver damage has occurred in overweight and obese individuals. This approach has clinical utility with respect to early scanning of liver injury or NAFLD based on routinely available metabolic data in overweight and obese population.
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, China ; College of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou 325035, China.
authors.forename: Lufeng
authors.initials: L
authors.lastname: Hu
authors.affiliation: Beijing Hui-Long-Guan Hospital, Peking University Beijing 100096, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.affiliation: The Affiliated Wenling Hospital of Wenzhou Medial University Wenling 317500, China.
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Xu
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou 325035, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou 325035, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Lin
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou 325035, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Henan Provincial People's Hospital Zhengzhou 450003, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: The Affiliated Eye Hospital of Wenzhou Medical University Wenzhou, 325027, China.
authors.forename: Youpei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou 325035, China.
authors.forename: Lingxia
authors.initials: L
authors.lastname: Pang
authors.affiliation: The Affiliated Eye Hospital of Wenzhou Medical University Wenzhou, 325027, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University Shaoxing 312000, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Ningbo Fourth Hospital Xiangshan 315700, China.
authors.forename: Guoshi
authors.initials: G
authors.lastname: Qiu
authors.affiliation: Ningbo Fourth Hospital Xiangshan 315700, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Ningbo Fourth Hospital Xiangshan 315700, China.
authors.forename: Longteng
authors.initials: L
authors.lastname: Xie
authors.affiliation: College of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou 325035, China.
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Liu
keywords: ALT; AST; BP-ANN; GGT; metabolic parameters