title: Level of Blood Cell-Free Circulating Mitochondrial DNA as a Novel Biomarker of Acute Myocardial Ischemia.
abstract: Changes in the level of blood cell-free circulating mitochondrial DNA were examined during experimental adrenaline-induced myocardial injury in rats. The amount of mitochondrial DNA in the blood was significantly elevated at 48 and 72 h after subcutaneous injection of adrenaline solution, and it was accompanied by development of multiple small-focal myocardial ischemia. This suggests that the measured level of blood cell-free circulating mitochondrial DNA might be used as a biomarker of acute myocardial ischemia.
authors.affiliation: Irkutsk Surgery and Traumatology Research Center, Irkutsk, 664003, Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Sudakov
authors.forename: T P
authors.initials: TP
authors.lastname: Popkova
authors.forename: A I
authors.initials: AI
authors.lastname: Katyshev
authors.forename: O A
authors.initials: OA
authors.lastname: Goldberg
authors.forename: S B
authors.initials: SB
authors.lastname: Nikiforov
authors.forename: B G
authors.initials: BG
authors.lastname: Pushkarev
authors.forename: I V
authors.initials: IV
authors.lastname: Klimenkov
authors.forename: S A
authors.initials: SA
authors.lastname: Lepekhova
authors.forename: K A
authors.initials: KA
authors.lastname: Apartsin
authors.forename: G A
authors.initials: GA
authors.lastname: Nevinsky
authors.forename: Yu M
authors.initials: YM
authors.lastname: Konstantinov
mesh_terms: D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003600:Cytosol / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000097:blood*; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D004272:DNA, Mitochondrial; D004837:Epinephrine