title: Dynamics of Particle Size on Inhalation of Environmental Aerosol and Impact on Deposition Fraction.
abstract: Inhalation of elevated levels of particulate air pollution has been shown to elicit the onset of adverse health effects in humans, where the magnitude of the response is a product of where in the lung the particulate dose is delivered. At any point in time during inhalation the depositional flux of the aerosol is a function of the radius of the droplet, thus a detailed understanding of the rate and magnitude of the mass flux of water to the droplet during inhalation is crucial. In this study, we assess the impact of aerosol hygroscopicity on deposited dose through the inclusion of a detailed treatment of the mass flux of water to account for the dynamics of particle size in a modified version of the standard International Commission on Radiological Protection (ICRP) whole lung deposition model. The ability to account for the role of the relative humidity (RH) of the aerosol prior to, and during, inhalation on the deposition pattern is explored, and found to have a significant effect on the deposition pattern. The model is verified by comparison to previously published measurements, and used to demonstrate that ambient RH affects where in the lung indoor particulate air pollution is delivered.
authors.affiliation: School of Chemistry, University of Bristol , Bristol, U.K. , BS8 1TS.
authors.forename: Allen E
authors.initials: AE
authors.lastname: Haddrell
authors.affiliation: School of Chemistry, University of Bristol , Bristol, U.K. , BS8 1TS.
authors.forename: James F
authors.initials: JF
authors.lastname: Davies
authors.affiliation: School of Chemistry, University of Bristol , Bristol, U.K. , BS8 1TS.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Reid
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry; D016902:Air Pollution, Indoor / Q000032:analysis; D004777:Environment; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D006801:Humans; D006813:Humidity; D008168:Lung / Q000187:drug effects*; D008962:Models, Theoretical; D010316:Particle Size; D052638:Particulate Matter / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry*; D017155:Wettability
chemical_list: D000336:Aerosols; D052638:Particulate Matter