title: [EFFECT OF PROPARGYLGLYCINE UPON CARDIOHEMODYNAMICS IN OLD RATS].
abstract: Aging increases the risk of cardiovascular diseases. The objective of this study was to show the effect of propargylg- lycine (PPG) upon cardiohemodynamics in old rats. We used pressure-volume (PV) conductance catheter system (Millar Instruments, USA) in order to evaluate systolic and diastolic function in vivo. It has been shown that introducted PPG (11,31 mg/kg) decrises both arterial stiffness (by 1,5 times) and end-diastolic stiffness (by 2,1 times) in old rats. Using PPG in heart mitochondria resulted in increasing levels of H2S (by 112%), NO2- (by 162%) and in growing activity of cNOS (by 3 times). Additionally, PPG decreased the mitochondrial pools of the uric acid, the marker of the superoxide (*O2-) formation and of the ATP degradation. These results suggest that PPG activates alternative ways of H2S synthesis, stimulates the NO and H2S synthesis and suppresses the ATP degradation and *O2 formation. These actions of PPG improve arterial stiffness and end-diastolic stiffness.
authors.forename: K O
authors.initials: KO
authors.lastname: Drachuk
authors.forename: N A
authors.initials: NA
authors.lastname: Dorofeyeva
authors.forename: A V
authors.initials: AV
authors.lastname: Kotsjuruba
authors.forename: V F
authors.initials: VF
authors.lastname: Sagach
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000480:Alkynes / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003971:Diastole / Q000187:drug effects* / Q000502:physiology; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006325:Heart Atria / Q000187:drug effects*; D006862:Hydrogen Sulfide / Q000378:metabolism*; D007273:Injections, Intramuscular; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013318:Stroke Volume / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism; D013599:Systole / Q000187:drug effects* / Q000502:physiology; D014527:Uric Acid / Q000378:metabolism; D059289:Vascular Stiffness / Q000187:drug effects
chemical_list: D000480:Alkynes; D013481:Superoxides; D014527:Uric Acid; D009569:Nitric Oxide; C009055:propargylglycine; D000255:Adenosine Triphosphate; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D005998:Glycine; D006862:Hydrogen Sulfide