title: Warmth and nociceptive evoked potentials in cold-induced sweating syndrome type 1.
abstract: Cold-induced sweating syndrome type 1 (CISS1), is a rare, severe, autosomal recessive disease. It is characterized by morphological alterations and profuse sweating when ambient temperature is <22 °C. Although some individuals with CISS1 have decreased pain perception, no study has been conducted to evaluate thermal and pain sensations in these patients. The aim of this study was to assess the function of the nociceptive Aδ-fibers and warmth C-fibers by using CO2 laser-evoked potentials (LEPs) in patients affected by CISS1.
  
  
  
  Four patients were studied. Laser pulses were applied to the skin of the right hand and the perioral region at painful intensity to record Aδ-LEPs, and at non-painful intensity to obtain C-LEPs. Fifteen healthy subjects were studied for control purposes.
  
  
  
  No significant difference in latencies or amplitudes of either Aδ- or C-LEPs was found between the 2 groups.
  
  
  
  Cutaneous nociceptive and warmth pathway functions are normal in CISS1. Muscle Nerve 54: 100-103, 2016.
authors.affiliation: Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario "A. Gemelli,", Largo Agostino Gemelli No. 8, 00168, Rome, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Testani
authors.affiliation: Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario "A. Gemelli,", Largo Agostino Gemelli No. 8, 00168, Rome, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Della Marca
authors.affiliation: Department of Paediatrics, Catholic University, Rome, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: La Torraca
authors.affiliation: Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Policlinico Universitario "A. Gemelli,", Largo Agostino Gemelli No. 8, 00168, Rome, Italy.
authors.forename: Catello
authors.initials: C
authors.lastname: Vollono
authors.affiliation: Department of Pediatrics and Clinical Medicine, Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Cagliari, Italy.
authors.forename: Giangiorgio
authors.initials: G
authors.lastname: Crisponi
authors.affiliation: Department of Paediatrics, Catholic University, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zampino
authors.affiliation: Neurology Division, Pediatric Hospital "Bambino Gesù" IRCCS, Rome, Italy.|Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Valeriani
mesh_terms: D000293:Adolescent; D000328:Adult; D003645:Death, Sudden; D019066:Facies; D005260:Female; D006228:Hand Deformities, Congenital / Q000503:physiopathology*; D006801:Humans; D006945:Hyperhidrosis / Q000503:physiopathology*; D066331:Laser-Evoked Potentials / Q000502:physiology*; D008297:Male; D059225:Nociception / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012867:Skin / Q000294:innervation; D013696:Temperature; D014313:Trismus / Q000151:congenital* / Q000503:physiopathology
keywords: Aδ-fibers; C-fibers; CISS1; cold-induced sweating; laser-evoked potentials