title: Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction.
abstract: BACKGROUND
  Early diagnosis and therapeutic intervention can improve the outcome of acute myocardial infarction (AMI). However, there are no satisfactory cardiac biomarkers for the diagnosis of AMI within 6 hours of onset of symptoms. Among novel biochemical markers of AMI, heart-type fatty acid binding protein (H-FABP) is of particular interest.
  
  
  OBJECTIVE
  To compare the diagnostic value of H-FABP with that of CK-MB and myoglobin in suspected AMI patients within first 6 hours after the onset of symptoms.
  
  
  METHODS
  The study includes 40 AMI cases and 40 non-cardiac chest pain otherwise healthy controls. The cases and controls were further divided into 2 groups depending on the time since chest pain as those subjects within 3 hours and those between 3-6 hours of onset of chest pain.
  
  
  METHODS
  In all the cases and controls, serum H-FABP, CK-MB and myoglobin concentrations were measured by Immunoturbidimetric method, immuno-inhibition method and Chemiluminescence immunoassay respectively.
  
  
  METHODS
  Data is presented as mean ± SD values. Differences between means of two groups were assessed by Student t-test. Sensitivity, Specificity, Positive predictive value, Negative predictive values were calculated and ROC curve analysis was done to assess the diagnostic validity of each study parameter.
  
  
  RESULTS
  The sensitivity, specificity, PPV, NPV of H-FABP were greater than CK-MB and myoglobin and ROC curve analysis demonstrated highest area under curve for H-FABP followed by myoglobin and CK-MB in patients with suspected AMI both within 3 hours and 3-6 hours after the onset of chest pain.
  
  
  CONCLUSIONS
  The diagnostic efficiency of H-FABP is greater than CK-MB and myoglobin for the early diagnosis of AMI within first 6 hours of chest pain. H-FABP can be used as an additional diagnostic tool for the early diagnosis of AMI.
authors.affiliation: Ph.D Scholar, Department of Biochemistry, BLDE University's Shri B M Patil Medical College, Hospital & Research Centre , Vijayapur, Karnataka, India .
authors.forename: Anand K
authors.initials: AK
authors.lastname: Pyati
authors.affiliation: Professor and Head, Department of Biochemistry, BLDE University's Shri B M Patil Medical College, Hospital & Research Centre , Vijayapur, Karnataka, India .
authors.forename: Basavaraj B
authors.initials: BB
authors.lastname: Devaranavadagi
authors.affiliation: Assistant Professor, Department of Cardiology, BLDE University's Shri B M Patil Medical College , Hospital & Research Centre, Vijayapur, Karnataka, India .
authors.forename: Sanjeev L
authors.initials: SL
authors.lastname: Sajjannar
authors.affiliation: Professor and Head, Department of Biochemistry, Belagavi Institute of Medical Sciences , Belagavi, Karnataka, India .
authors.forename: Shashikant V
authors.initials: SV
authors.lastname: Nikam
authors.affiliation: Lecturer, Statistics, Department of Community Medicine, BLDE University's Shri B M Patil Medical College, Hospital & Research Centre , Vijayapur, Karnataka, India .
authors.forename: Mohd
authors.initials: M
authors.lastname: Shannawaz
authors.affiliation: Post Graduate Student, Department of Pedodontics and Preventive Dentistry, Navodaya Dental College , Raichur, India .
authors.lastname: Sudharani
keywords: Chest pain; Diagnostic validity; Immunoturbidimetric method; ROC analysis; Sensitivity