title: Charting the landscape of priority problems in psychiatry, part 2: pathogenesis and aetiology.
abstract: This is the second of two companion papers proposing priority problems for research on mental disorders. Whereas the first paper focuses on questions of nosology and diagnosis, this Personal View concerns pathogenesis and aetiology of psychiatric diseases. We hope that this (non-exhaustive and subjective) list of problems, nominated by scientists and clinicians from different fields and institutions, provides guidance and perspectives for choosing future directions in psychiatric science.
authors.affiliation: Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich, Zurich, Switzerland; ETH Zurich, Zurich, Switzerland; The Wellcome Trust Centre for Neuroimaging, University College London, London, UK; Max Planck Institute for Metabolism Research, Cologne, Germany. Electronic address: stephan@biomed.ee.ethz.ch.
authors.forename: Klaas E
authors.initials: KE
authors.lastname: Stephan
authors.affiliation: Deptartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Elisabeth B
authors.initials: EB
authors.lastname: Binder
authors.affiliation: QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Metro North Mental Health Service, Brisbane, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Breakspear
authors.affiliation: Gatsby Computational Neuroscience Unit, University College London, London, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Dayan
authors.affiliation: Department of Psychiatry, University of Edinburgh, Edinburgh, UK.
authors.forename: Eve C
authors.initials: EC
authors.lastname: Johnstone
authors.affiliation: Central Institute of Mental Health, University of Mannheim, Mannheim, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Meyer-Lindenberg
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schnyder
authors.affiliation: Center for Neural Science, New York University, New York, NY, USA; Institute of Brain and Cognitive Science, NYU Shanghai, Shanghai, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zurich, Zurich, Switzerland; The Wellcome Trust Centre for Neuroimaging, University College London, London, UK.
authors.forename: Dominik R
authors.initials: DR
authors.lastname: Bach
authors.affiliation: Department of Psychiatry, University of Cambridge, Cambridge, UK.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Fletcher
authors.affiliation: The Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Flint
authors.affiliation: Brown Institute for Brain Science, Brown University, Providence, RI, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Frank
authors.affiliation: Department of Psychiatry, Humboldt University Berlin, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
authors.affiliation: Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich, Zurich, Switzerland; Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zurich, Zurich, Switzerland; ETH Zurich, Zurich, Switzerland.
authors.forename: Quentin J M
authors.initials: QJM
authors.lastname: Huys
authors.affiliation: The Wellcome Trust Centre for Neuroimaging, University College London, London, UK; Computational Psychiatry Unit, Virginia Tech Carilion Research Institute, Roanoke, VA, USA.
authors.forename: P Read
authors.initials: PR
authors.lastname: Montague
authors.affiliation: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK; Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.affiliation: The Wellcome Trust Centre for Neuroimaging, University College London, London, UK.
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Friston
mesh_terms: D006801:Humans; D001523:Mental Disorders / Q000209:etiology* / Q000473:pathology*; D011570:Psychiatry; D012106:Research