title: Efficacy of Extended-Interval Dosing of Micafungin Evaluated Using a Pharmacokinetic/Pharmacodynamic Study with Humanized Doses in Mice.
abstract: The pharmacokinetic/pharmacodynamic (PK/PD) characteristics of the echinocandins favor infrequent administration of large doses. The in vivo investigation reported here tested the utility of a range of humanized dose levels of micafungin using a variety of prolonged dosing intervals for the prevention and therapy of established disseminated candidiasis. Humanized doses of 600 mg administered every 6 days prevented fungal growth in prophylaxis. Humanized doses of 300 to 1,000 mg administered every 6 days demonstrated efficacy for established infections.
authors.affiliation: University of Wisconsin, Madison, Wisconsin, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lepak
authors.affiliation: Middleton VA Hospital, Madison, Wisconsin, USA.
authors.forename: K
authors.initials: K
authors.lastname: Marchillo
authors.affiliation: Middleton VA Hospital, Madison, Wisconsin, USA.
authors.forename: J
authors.initials: J
authors.lastname: VanHecker
authors.affiliation: Astellas Pharmaceuticals, Northbrook, Illinois, USA.
authors.forename: N
authors.initials: N
authors.lastname: Azie
authors.affiliation: University of Wisconsin, Madison, Wisconsin, USA Middleton VA Hospital, Madison, Wisconsin, USA dra@medicine.wisc.edu.
authors.forename: D
authors.initials: D
authors.lastname: Andes
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D054714:Echinocandins / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D055666:Lipopeptides / Q000493:pharmacokinetics* / Q000494:pharmacology; D000077551:Micafungin; D051379:Mice; D008826:Microbial Sensitivity Tests; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin