title: Alcohol Doesn't Always Compromise Cognitive Function: Exploring Moderate Doses in Young Adults.
abstract: OBJECTIVE
  The purpose of this study was to clarify inconsistent findings regarding the acute cognitive effects of subintoxicating alcohol doses (i.e., <80 mg/dl) by controlling for and evaluating variables that might modulate dose-related outcomes.
  
  
  METHODS
  The current study examined the effects of sex/gender and alcohol concentration on select cognitive functions in 94 individuals (49 men) between 25 and 35 years of age. Participants were randomly assigned to one of three dose conditions: target peak breath alcohol concentration of 0 mg/dl (placebo), 40 mg/dl (low), or 65 mg/dl (moderate). After beverage consumption, they completed tasks assessing psychomotor, set-shifting, and working memory ability.
  
  
  RESULTS
  Analyses revealed no significant effect of dose for any cognitive domain. A trend-level effect of dose on psychomotor performance was observed, with the low-dose group performing somewhat better than the moderate-dose and placebo groups. No sex main effects or interactions were revealed.
  
  
  CONCLUSIONS
  Consistent with our previous studies, these data suggest that low and moderate doses of alcohol may not compromise cognitive ability in non-problem drinkers under certain task conditions. Given the outcomes, sex differences cannot be meaningfully addressed. Future consideration of potentially influential variables and assessment of similarly well-defined cohorts might yield a clearer interpretation of alcohol's behavioral consequences.
authors.affiliation: Department of Psychiatry, University of Florida, Gainesville, Florida.
authors.forename: Laurena
authors.initials: L
authors.lastname: Hoffman
authors.affiliation: Department of Psychiatry, University of Florida, Gainesville, Florida.
authors.forename: Sara Jo
authors.initials: SJ
authors.lastname: Nixon
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000523:psychology*; D003071:Cognition / Q000187:drug effects*; D004311:Double-Blind Method; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D000431:Ethanol