title: Nanofiller for the mechanical reinforcement of maltodextrins orodispersible films.
abstract: One of the most critical quality attributes of orodispersible films (ODFs) is related to the development of dosage forms with tensile properties suitable for the packaging and patient's handling. Aiming to develop a strategy to reinforce the tensile properties, the current work reported the feasibility to improve the tensile strength of maltodextrins (MDX) based ODFs by adding an amorphous water insoluble nanofiller, namely polyvinylacetate (PVAc). The possible interactions between components investigated by DSC and ATR-FTIR spectroscopy revealed that MDX and PVAc were immiscible; even if, the presence of plasticizers permitted the homogeneous dispersion of PVAc in the film until the 10% w/w concentration was reached. As a consequence, PVAc nanoparticles was found to be an effective reinforcing agent only at the concentrations of 3 and 5% w/w. In this optimal range, the tensile strength increased at least 1.5 fold and the elastic modulus increased at least 4 times.
authors.affiliation: Department of Pharmaceutical Sciences - Università degli Studi di Milano, Via Giuseppe Colombo, 71, 20133 Milan, Italy. Electronic address: ilaria.franceschini@unimi.it.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Franceschini
authors.affiliation: Department of Pharmaceutical Sciences - Università degli Studi di Milano, Via Giuseppe Colombo, 71, 20133 Milan, Italy. Electronic address: francesca.selmin@unimi.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Selmin
authors.affiliation: BOUTY S.p.A, S.S. no 11, Padana Superiore km 160, 20060 Cassina de' Pecchi (MI), Italy. Electronic address: Stefania.Pagani@adarepharma.com.
authors.forename: Stefania
authors.initials: S
authors.lastname: Pagani
authors.affiliation: Department of Pharmaceutical Sciences - Università degli Studi di Milano, Via Giuseppe Colombo, 71, 20133 Milan, Italy. Electronic address: paola.minghetti@unimi.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Minghetti
authors.affiliation: Department of Pharmaceutical Sciences - Università degli Studi di Milano, Via Giuseppe Colombo, 71, 20133 Milan, Italy. Electronic address: francesco.cilurzo@unimi.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Cilurzo
mesh_terms: D065546:Drug Liberation; D053758:Nanoparticles / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D011134:Polysaccharides; D011145:Polyvinyls; C013215:polyvinyl acetate; C008315:maltodextrin
keywords: Casting solution; Maltodextrins; Mechanical reinforcement; Nanofiller; Orodispersible films; Tensile properties