title: An expeditious green route toward 2-aryl-4-phenyl-1H-imidazoles.
abstract: BACKGROUND
  Azaheterocycles are an important class of compounds because of their highly potent medicinal activities, and the imidazole subcategory is of special interest in regard to drug discovery research.
  
  
  RESULTS
  An expeditious synthetic protocol of 2-aryl-4-phenyl-1H-imidazoles has been accomplished by reacting phenylglyoxal monohydrate, ammonium acetate, and aldehyde under sonication. Following this green approach a series of 2-aryl-4-phenyl-1H-imidazoles has been synthesized using diversely substituted aldehydes.
  
  
  CONCLUSIONS
  A rapid and simple synthetic procedure to synthesize diversely substituted 2-aryl-4-phenyl-1H-imidazoles has been reported. Other salient features of this protocol include milder conditions, atom-economy, easy extraction, and minimum wastes. The present procedure may find application in the synthesis of biologically active molecules. Graphical Abstract An expeditious synthetic protocol of 2-aryl-4-phenyl-1H-imidazoles has been accomplished by reacting phenylglyoxal monohydrate, ammonium acetate, and diversely substituted aldehydes under sonication.
authors.affiliation: Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. bandyopad@utpa.edu.
authors.forename: Debasish
authors.initials: D
authors.lastname: Bandyopadhyay
authors.affiliation: Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. lcsmith@broncs.utpa.edu.
authors.forename: Lauren C
authors.initials: LC
authors.lastname: Smith
authors.affiliation: Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. drgarcia4@broncs.utpa.edu.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Garcia
authors.affiliation: Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. yadavrn@utpa.edu.
authors.forename: Ram N
authors.initials: RN
authors.lastname: Yadav
authors.affiliation: Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. banik@utpa.edu.
authors.forename: Bimal K
authors.initials: BK
authors.lastname: Banik
keywords: Azaheterocycles; Green chemistry; Heterocycles; Imidazole; Medicinal chemistry; Ultrasound