title: N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones.
abstract: The dynamic kinetic resolution of 6-hydroxypyranones with enals or alkynals through an asymmetric redox esterification is catalyzed by a chiral N-heterocyclic carbene. The resulting esters are obtained in good to high yields and with high levels of enantio- and diastereocontrol. The reaction products are further derivatized to obtain functionalized sugar derivatives and natural products.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.|Tsinghua-Peking Centre for Life Sciences, Beijing, 100084, China.
authors.forename: Changgui
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
authors.forename: Fangyi
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. wangjian2012@tsinghua.edu.cn.|Tsinghua-Peking Centre for Life Sciences, Beijing, 100084, China. wangjian2012@tsinghua.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
keywords: N-heterocyclic carbenes; catalysis; dynamic kinetic resolution; glycosylation; pyranones