title: High rate of lymphoma among a UK cohort of adolescents with vertically acquired HIV-1 infection transitioning to adult care in the era of antiretroviral therapy.
abstract: Among an inner London UK cohort of 147 adolescents transitioning from paediatric into adult care between 2007 and 2015, a new diagnosis of lymphoma was made in five patients; incidence rate = 0.425/100 person-years (95% confidence interval = 0.424-0.426). Previously described risk factors, including low nadir CD4 cell count and ongoing HIV-1 viraemia, appeared to be important. These data suggest that careful surveillance and a low threshold for investigating relevant symptoms continue to be essential for such patients.
authors.affiliation: aDepartment of Sexual Health, Mortimer Market Centre, Central & North West London NHS Foundation TrustbCentre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, London, UK.
authors.forename: Chris P
authors.initials: CP
authors.lastname: Eades
authors.forename: Sophie A
authors.initials: SA
authors.lastname: Herbert
authors.forename: Simon G
authors.initials: SG
authors.lastname: Edwards
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Waters
authors.forename: Tabitha
authors.initials: T
authors.lastname: Peake
authors.forename: Robert F
authors.initials: RF
authors.lastname: Miller
authors.forename: Eva
authors.initials: E
authors.lastname: Jungmann
mesh_terms: D000293:Adolescent; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008131:London / Q000453:epidemiology; D008223:Lymphoma / Q000453:epidemiology*; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D019562:Viral Load; D055815:Young Adult