title: Outcome of Stretta radiofrequency and fundoplication for GERD-related severe asthmatic symptoms.
abstract: This study aimed to investigate the outcome of treatment with Stretta radiofrequency (SRF) or laparoscopic Nissen fundoplication (LNF). A total of 137 gastroesophageal reflux disease (GERD) patients with severe asthmatic symptoms who responded inadequately to medical treatment for asthma were investigated. The patients were followed up 1 year and 5 years after SRF (n = 82) or LNF (n = 55) treatment. A questionnaire covering 29 related symptoms and medication use was employed. Digestive, respiratory, and ear-nose-throat (ENT) symptom scores significantly decreased after antireflux treatment. Symptom scores respectively changed from 17.2 ± 10.1, 31.9 ± 6.6, and 21.1 ± 11.8 to 5.0 ± 6.2, 11.5 ± 10.2, and 6.3 ± 6.8 at 1 year and to 5.6 ± 6.5, 13.1 ± 10.1, and 7.8 ± 7.2 at 5 years (P < 0.001). The outcome of LNF was significantly better than that of SRF in terms of digestive (P < 0.001, P = 0.001), respiratory (P = 0.006, P = 0.001), and ENT symptoms (P = 0.006, P = 0.003) at both 1 year and 5 years. SRF and LNF were both effective against the digestive symptoms of GERD as well as GERD-related severe asthmatic and ENT symptoms, with better outcomes exhibited by the LNF group. Severe asthmatic symptoms and GERD were closely associated, and this finding warrants further study.
authors.affiliation: Department of Gastroesophageal Reflux Disease, the Second Artillery General Hospital PLA, Beijing, 100088, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Gastroesophageal Reflux Disease, the Second Artillery General Hospital PLA, Beijing, 100088, China.
authors.forename: Jimin
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Gastroesophageal Reflux Disease, the Second Artillery General Hospital PLA, Beijing, 100088, China. zhonggaowang@126.com.
authors.forename: Zhonggao
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Gastroesophageal Reflux Disease, the Second Artillery General Hospital PLA, Beijing, 100088, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Gastroesophageal Reflux Disease, the Second Artillery General Hospital PLA, Beijing, 100088, China.
authors.forename: Weitao
authors.initials: W
authors.lastname: Liang
authors.affiliation: Department of Gastroesophageal Reflux Disease, the Second Artillery General Hospital PLA, Beijing, 100088, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods; D002681:China; D016145:Endoscopy, Digestive System / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication / Q000009:adverse effects / Q000379:methods; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D063189:Symptom Assessment; D016896:Treatment Outcome
keywords: Stretta radiofrequency; asthma; gastroesophageal reflux; laparoscopic Nissen fundoplication