title: Zinc-Catalyzed Dehydrogenative Cross-Coupling of Terminal Alkynes with Aldehydes: Access to Ynones.
abstract: Because of the lack of redox ability, zinc has seldom been used as a catalyst in dehydrogenative cross-coupling reactions. Herein, a novel zinc-catalyzed dehydrogenative C(sp(2) )H/C(sp)H cross-coupling of terminal alkynes with aldehydes was developed, and provides a simple way to access ynones from readily available materials under mild reaction conditions. Good reaction selectivity can be achieved with a 1:1 ratio of terminal alkyne and aldehyde. Various terminal alkynes and aldehydes are suitable in this transformation.
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei (P.R. China) http://aiwenlei.whu.edu.cn/Main_Website/
authors.forename: Shan
authors.initials: S
authors.lastname: Tang
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei (P.R. China) http://aiwenlei.whu.edu.cn/Main_Website/
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei (P.R. China) http://aiwenlei.whu.edu.cn/Main_Website/
authors.forename: Yichang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei (P.R. China) http://aiwenlei.whu.edu.cn/Main_Website/. aiwenlei@whu.edu.cn.|National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022 (P.R. China). aiwenlei@whu.edu.cn.
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
keywords: CH activation; cross-coupling; dehydrogenation; homogeneous catalysis; zinc