title: Impact of anaemia on long-term outcomes in patients treated with first- and second-generation drug-eluting stents; Katowice-Zabrze Registry.
abstract: BACKGROUND
  Coexisting anaemia is associated with an increased risk of major adverse cardiac and cerebrovascular events (MACCE) and bleeding complications after percutaneous coronary intervention (PCI), especially in patients with acute coronary syndrome.
  
  
  OBJECTIVE
  To assess the impact of anaemia in patients with coronary artery disease (CAD) treated with first- and second-generation drug-eluting stents (DES) on one-year MACCE.
  
  
  RESULTS
  The registry included 1916 consecutive patients (UA: n = 1502, 78.3%; NSTEMI: n = 283, 14.7%; STEMI/LBBB: n = 131, 6.8%) treated either with first- (34%) or second-generation (66%) DES. The study population was divided into two groups: patients presenting with anaemia 217 (11%) and without anaemia 1699 (89%) prior to PCI. Anaemia was defined according to World Heart Organisation (haemoglobin [Hb] level < 13 g/dL for men and < 12 g/dL for women). Patients with anaemia were older (69, IQR: 61-75 vs. 62, IQR: 56-70, p < 0.001), had higher prevalence of co-morbidities: diabetes (44.7% vs. 36.4%, p = 0.020), chronic kidney disease (31.3% vs. 19.4%; p < 0.001), peripheral artery disease (10.1% vs. 5.4%, p = 0.005), and lower left ventricular ejection fraction values (50, IQR: 40-57% vs. 55, IQR: 45-60%; p < 0.001). No difference between gender in frequency of anaemia was found. Patients with anaemia more often had prior myocardial infarction (MI) (57.6% vs. 46.4%; p = 0.002) and coronary artery bypass grafting (31.3% vs. 19.4%; p < 0.001) in comparison to patients without anaemia. They also more often had multivessel disease in angiography (36.4% vs. 26.1%; p = 0.001) and more complexity CAD as measured by SYNTAX score (21, IQR: 12-27 points vs. 14, IQR: 8-22 points; p = 0.001). In-hospital risk of acute heart failure (2.7% vs. 0.7%; p = 0.006) and bleeding requiring transfusion (3.2% vs. 0.5%; p < 0.001) was significantly higher in patients with anaemia. One-year follow-up showed that there was higher rate of death in patients with anaemia. However, there were no differences in MI, stroke, target vessel revascularisation (TVR) and MACCE in comparison to patients with normal Hb. There were no differences according to type of DES (first vs. second generation) in the population of patients with anaemia.
  
  
  CONCLUSIONS
  In patients with anaemia there is a significantly higher risk of death in 12-month follow-up, but anaemia has no impact on the incidence of MI, repeat revascularisation, stroke and MACCE. There is no advantage of II-DES over I-DES generation in terms of MACCE and TVR in patients with anaemia.
authors.affiliation: 3rd Division of Cardiology, Medical University of Silesia, Katowice, Poland. wojciech.wanha@gmail.com.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wańha
authors.forename: Damian
authors.initials: D
authors.lastname: Kawecki
authors.forename: Tomasz
authors.initials: T
authors.lastname: Roleder
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Pluta
authors.forename: Kamil
authors.initials: K
authors.lastname: Marcinkiewicz
authors.forename: Janusz
authors.initials: J
authors.lastname: Dola
authors.forename: Beata
authors.initials: B
authors.lastname: Morawiec
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Krzych
authors.forename: Tomasz
authors.initials: T
authors.lastname: Pawłowski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Smolka
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ochała
authors.forename: Ewa
authors.initials: E
authors.lastname: Nowalany-Kozielska
authors.forename: Michał
authors.initials: M
authors.lastname: Tendera
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wojakowski
mesh_terms: D054058:Acute Coronary Syndrome / Q000601:surgery*; D000368:Aged; D000740:Anemia / Q000150:complications*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011044:Poland; D011379:Prognosis; D012042:Registries; D012307:Risk Factors
keywords: anaemia; drug eluting stents; percutaneous coronary intervention