title: Prevention of a Parastomal Hernia by Biological Mesh Reinforcement.
abstract: BACKGROUND
  In the field of hernia prevention, the prophylactic mesh-reinforcement of stoma-sites is one of the most controversially discussed issues. The incidence of parastomal hernias in the literature reported to be up to 48.1% after end colostomy and up to 30.8% after loop of colostomy, but still remains uncertain due to diagnostic variety of clinical or radiological methods, heterogeneous patient groups and variable follow-up intervals. Anyway, the published data regarding the use of synthetic or bio-prostethic meshes in the prevention of parastomal hernia at the primary operation are very scarce.
  
  
  METHODS
  A literature search of the Medline database in terms of biological prophylactic mesh implantation in stoma creation identified six systematic reviews, two randomized controlled trials (RCT), two case-controlled studies, and one technical report.
  
  
  RESULTS
  In a systematic review focusing on the prevention of parastomal hernia including only RCTs encompassing one RCT using bio-prosthetic mesh the incidence of herniation was 12.5% compared to 53% in the control group (p < 0.0001). In one RCT and two case-control studies, respectively, there was a significant smaller incidence of parastomal herniation as well as a similar complication rate compared to the control group. Only in one RCT, no significant difference regarding the incidence of parastomal hernia was reported with comparable complication rates.
  
  
  CONCLUSIONS
  Thus, so far two RCT and two case-control studies are published with prophylactic bio-prosthetic reinforcement in stoma sites. The majority revealed significant better results in terms of parastomal herniation and without any mesh-related complications in comparison to the non mesh group. Further, multicenter RCT are required to achieve a sufficient level of recommendation.
authors.affiliation: Department of General, Visceral and Oncological Surgery, Wilhelminenspital , Vienna , Austria.
authors.forename: René H
authors.initials: RH
authors.lastname: Fortelny
authors.affiliation: Department of General, Visceral and Oncological Surgery, Wilhelminenspital , Vienna , Austria.
authors.forename: Anna
authors.initials: A
authors.lastname: Hofmann
authors.affiliation: Department of General, Visceral and Oncological Surgery, Wilhelminenspital , Vienna , Austria.
authors.forename: Christopher
authors.initials: C
authors.lastname: May
authors.affiliation: Department of Surgery and Center for Minimally Invasive Surgery, Vivantes Hospital , Berlin , Germany.
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Köckerling
keywords: bio mesh; bio-prostethic mesh; biologic mesh; parastomal hernia; parastomal hernia prevention; parastomal hernia repair