title: Review: The Role of Insulin-like Growth Factor-1 Signaling Pathways in Uterine Leiomyoma.
abstract: A growing body of evidence suggests the association of the IGF-I bio-regulatory system with leiomyoma occurrence and growth. The complex interplay between IGF-I/IGF-IR and hormonal and other growth factors is, thus, now receiving significant attention. Elucidation of the molecular mechanisms driving the disease may allow for development of novel targeted-therapeutic strategies for the treatment of leiomyomas. Herein, we provide a concise update and overview of the function and regulation of IGF-I and its role in leiomyoma growth.
authors.affiliation: Department of Experimental Physiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
authors.forename: Eliona
authors.initials: E
authors.lastname: Gkioka
authors.affiliation: Albert Einstein College of Medicine, Jacobi Medical Center, Bronx, NY, U.S.A.
authors.forename: Pavlos
authors.initials: P
authors.lastname: Msaouel
authors.affiliation: Department of Experimental Physiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
authors.forename: Anastassios
authors.initials: A
authors.lastname: Philippou
authors.affiliation: Department of Experimental Physiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
authors.forename: Nikolaos I
authors.initials: NI
authors.lastname: Vlaghogiannis
authors.affiliation: Department of Experimental Physiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
authors.forename: Christiana T
authors.initials: CT
authors.lastname: Vogkou
authors.affiliation: National Health System, Areopolis, Greece.
authors.forename: Argyris
authors.initials: A
authors.lastname: Margiolis
authors.affiliation: Department of Experimental Physiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece mkoutsil@med.uoa.gr.
authors.forename: Michael
authors.initials: M
authors.lastname: Koutsilieris
mesh_terms: D047628:Estrogen Receptor alpha / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism; D007889:Leiomyoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D047628:Estrogen Receptor alpha; D011980:Receptors, Progesterone; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1
keywords: IGFs; Leiomyomas; estrogen receptor; progesterone receptor; review