title: Mechanism of Treatment of Kidney Deficiency and Osteoporosis is Similar by Traditional Chinese Medicine.
abstract: Traditional Chinese medicine (TCM) is a theoretical based system and is completely different from western medicine and states that numerous diseases, especially chronic diseases, are cured or relieved. "Zheng" (syndrome) is a summarization of the pathological changes which take place during the different stages of the development of a disease, including its location, cause and nature as well as the state of both Xie-qi (pathogenic factors) and Zheng-qi (healthy energy). Compared to a single symptom, syndrome can demonstrate the nature of a disease more extensively, completely and correctly. However, it is difficult to compare "Zheng" to the western medicine theory, which is based on scientific evidence for the diagnosis and treatment of a specific disease. Estrogen deficiency is a major pathogenetic factor in bone loss after menopause and oophorectomy with the subsequent risk of developing osteoporosis. According to TCM theory, the kidney stores essence and this can transform into bone marrow to nourish the bones, strenghthen the skeleton by promoting growth and repair. The kidney deficiency can decrease the estrogen level adjusted by the gonadal axis, causing osteoporosis. Traditional Chinese medicines tonifying the kidney can significantly enhance the level of estrogen to alleviate osteoporosis. In combination with other evidence, we further deduce that the syndrome as defined within TCM has a similar pathological mechanism to that defined by western medicine. If TCM theory is to be understood and accepted, and further fused with the western medicine theory, the micro pathological basis of TCM syndrome must be investigated extensively, which will lead to bridging the two theories together. The fusion of TCM with western medicine will pay more attention to analyzing the common nature and difference of disease and syndrome. This paper reviews the way forward for new translational advances.
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Yue
authors.forename: Khalid
authors.initials: K
authors.lastname: Rahman
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Xin
authors.forename: Qiao-Yan
authors.initials: QY
authors.lastname: Zhang
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Qin
authors.affiliation: Central Laboratory, Shanghai Seventh People's Hospital, Shanghai 200137, PR China. zhanghong@smmu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D055808:Drug Discovery; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D010024:Osteoporosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D051437:Renal Insufficiency / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D004967:Estrogens