title: Polydatin Inhibits Formation of Macrophage-Derived Foam Cells.
abstract: Rhizoma Polygoni Cuspidati, a Chinese herbal medicine, has been widely used in traditional Chinese medicine for a long time. Polydatin, one of the major active ingredients in Rhizoma Polygoni Cuspidati, has been recently shown to possess extensive cardiovascular pharmacological activities. In present study, we examined the effects of Polydatin on the formation of peritoneal macrophage-derived foam cells in Apolipoprotein E gene knockout mice (ApoE(-/-)) and explored the potential underlying mechanisms. Peritoneal macrophages were collected from ApoE(-/-) mice and cultured in vitro. These cells sequentially were divided into four groups: Control group, Model group, Lovastatin group, and Polydatin group. Our results demonstrated that Polydatin significantly inhibits the formation of foam cells derived from peritoneal macrophages. Further studies indicated that Polydatin regulates the metabolism of intracellular lipid and possesses anti-inflammatory effects, which may be regulated through the PPAR-γ signaling pathways.
authors.affiliation: Department of Cardiovascular Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Meixia
authors.initials: M
authors.lastname: Liu
authors.affiliation: Qilu Hospital of Shandong University, Jinan 250012, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.affiliation: Shandong University of Traditional Chinese Medicine, Shandong 250355, China.
authors.forename: Wengao
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Longtao
authors.initials: L
authors.lastname: Liu