title: Intracellular host-guest assembly of gold nanoparticles triggered by glutathione.
abstract: A simple method to achieve host-guest assembly of gold nanoparticles triggered by intracellular glutathione was demonstrated. The increased size of nanoparticles not only enhanced their retention time within cancer cells, but also induced apoptosis. This strategy may open an avenue for the development of smart nanocarriers for intracellular diagnosis and therapy.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.forename: Huan
authors.initials: H
authors.lastname: Li
authors.forename: Qiao
authors.initials: Q
authors.lastname: Jin
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D005978:Glutathione / Q000737:chemistry* / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D056945:Hep G2 Cells / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D010316:Particle Size
chemical_list: D006046:Gold; D005978:Glutathione