title: HEPATOPROTECTIVE ACTIVITY OF EXOGENOUS RNA.
abstract: Hepatoprotective activity of Nuclex, a pharmaceutical composed of low-molecular yeast RNA, was investigated during acute and chronic thioacetamide-induced hepatotoxicity. It is demonstrated, that Nuclex administration at a dose of 200 mg/kg during acute and chronic liver injury produces hepatoprotective effect, which is associated with decrease in liver parenchyma lesions and in its inflammatory infiltration. Nuclex application attenuates thioacetamide-induced free radical damage of hepatic biopolymers, expressed in the reduction of TBA-reactive products, carbonyl derivatives, and recovery of protein thiol groups and reduced glutathione levels.
authors.forename: I O
authors.initials: IO
authors.lastname: Shmarakov
authors.forename: T V
authors.initials: TV
authors.lastname: Marchyshak
authors.forename: V L
authors.initials: VL
authors.lastname: Borschovetska
authors.forename: M M
authors.initials: MM
authors.lastname: Marchenko
authors.forename: Z Yu
authors.initials: ZY
authors.lastname: Tkachuk
mesh_terms: D000284:Administration, Oral; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004151:Dipeptides / Q000494:pharmacology; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D020556:Neutrophil Infiltration / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D012331:RNA, Fungal / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013853:Thioacetamide; D013858:Thiobarbiturates / Q000737:chemistry
chemical_list: D004151:Dipeptides; D005609:Free Radicals; D020011:Protective Agents; D012331:RNA, Fungal; D013438:Sulfhydryl Compounds; D013858:Thiobarbiturates; D013853:Thioacetamide; D005978:Glutathione; C029684:thiobarbituric acid; C024362:arginine glutamate