title: Drug-Polymer Electrostatic Complexes as New Structuring Agents for the Formation of Drug-Loaded Ordered Mesoporous Silica.
abstract: Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases. This phase behavior was evidenced by using poly(acrylic acid)-block-poly(ethylene oxide) block copolymers in the presence of silica precursors, and this allowed preparing drug-loaded mesoporous silica directly from the drug-polymer complexes. The novel synthetic strategy of the hybrid materials is highly efficient, avoiding waste and multistep processes; it also ensures optimal drug loading and provides pH-dependence of the drug release from the materials.
authors.affiliation: Institut Charles Gerhardt UMR 5253 CNRS/ENSCM/UM, ENSCM, Montpellier F-34295 Cedex, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Molina
authors.affiliation: Institut Charles Gerhardt UMR 5253 CNRS/ENSCM/UM, ENSCM, Montpellier F-34295 Cedex, France.|CERM, University of Liege , Sart Tilman, B-4000 Liege, Belgium.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Warnant
authors.affiliation: Institut Charles Gerhardt UMR 5253 CNRS/ENSCM/UM, ENSCM, Montpellier F-34295 Cedex, France.
authors.forename: Mélody
authors.initials: M
authors.lastname: Mathonnat
authors.affiliation: Institut Charles Gerhardt UMR 5253 CNRS/ENSCM/UM, ENSCM, Montpellier F-34295 Cedex, France.
authors.forename: Maël
authors.initials: M
authors.lastname: Bathfield
authors.affiliation: Laboratory Charles Coulomb, UMR 5221 CNRS/UM, University of Montpellier , F-34095 Montpellier Cedex 5, France.
authors.forename: Martin
authors.initials: M
authors.lastname: In
authors.affiliation: Institut Charles Gerhardt UMR 5253 CNRS/ENSCM/UM, ENSCM, Montpellier F-34295 Cedex, France.
authors.forename: Danielle
authors.initials: D
authors.lastname: Laurencin
authors.affiliation: CERM, University of Liege , Sart Tilman, B-4000 Liege, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Jérôme
authors.affiliation: Institut Charles Gerhardt UMR 5253 CNRS/ENSCM/UM, ENSCM, Montpellier F-34295 Cedex, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Lacroix-Desmazes
authors.affiliation: Institut Charles Gerhardt UMR 5253 CNRS/ENSCM/UM, ENSCM, Montpellier F-34295 Cedex, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Marcotte
authors.affiliation: Institut Charles Gerhardt UMR 5253 CNRS/ENSCM/UM, ENSCM, Montpellier F-34295 Cedex, France.
authors.forename: Corine
authors.initials: C
authors.lastname: Gérardin
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D055672:Static Electricity
chemical_list: D004337:Drug Carriers; D011108:Polymers; D011092:Polyethylene Glycols; D012822:Silicon Dioxide