title: Effect of acid-sensing ion channel 1a on the process of liver fibrosis under hyperglycemia.
abstract: Metabolic syndrome characterized by hyperglycemia contributes to nonalcoholic steatohepatitis-associated liver fibrosis. This study was to investigate the effects of Acid-sensing ion Channel 1a (ASIC1a) on the process of liver fibrosis under hyperglycemia. Results showed that high glucose significantly worsen the pathology of liver fibrosis in vivo. In vitro, high glucose stimulated proliferation, activation and extracellular matrix (ECM) production in HSCs, and enhanced the effect of PDGF-BB on the activation and proliferation of HSCs. These effects could be attenuated by ASIC1a specific inhibitor Psalmotoxin-1(PcTx1) or specific ShRNA for ASIC1a through Notch1/Hes-1 pathways. These data indicate that ASIC1a plays an important role in diabetes complication liver fibrosis.
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), Anhui Medical University, Hefei, 230032, China. Electronic address: wanghuan7@126.com.
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), Anhui Medical University, Hefei, 230032, China.
authors.forename: Ying-hong
authors.initials: YH
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), Anhui Medical University, Hefei, 230032, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), Anhui Medical University, Hefei, 230032, China.
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Li
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), Anhui Medical University, Hefei, 230032, China.
authors.forename: Yuan-yao
authors.initials: YY
authors.lastname: Tian
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), Anhui Medical University, Hefei, 230032, China.
authors.forename: Ming-ming
authors.initials: MM
authors.lastname: Ni
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), Anhui Medical University, Hefei, 230032, China.
authors.forename: Long-quan
authors.initials: LQ
authors.lastname: Zuo
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), Anhui Medical University, Hefei, 230032, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Meng
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), Anhui Medical University, Hefei, 230032, China. Electronic address: aydhy@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
mesh_terms: D062565:Acid Sensing Ion Channels / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D005947:Glucose / Q000378:metabolism*; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D051881:Receptor, Notch1 / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D062565:Acid Sensing Ion Channels; C568268:Asic1 protein, rat; C497763:Notch1 protein, rat; D051881:Receptor, Notch1; D005947:Glucose
keywords: Acid-sensing ion channel; Diabetes; Hepatic fibrosis; Hyperglycemia