title: Chemokine (C-C motif) ligand 5 -28C>G is significantly associated with an increased risk of tuberculosis: a meta-analysis.
abstract: OBJECTIVE
  Chemokine (C-C motif) ligand 5 (CCL5) has been shown to play an important role in antimycobacterial immune responses. Previous studies have extensively reported that the CCL5 -28C>G gene polymorphism is associated with susceptibility to tuberculosis (TB). However, the results of these studies have been inconsistent. To investigate the relationship between the CCL5 -28C>G and the risk of TB, we performed a meta-analysis.
  
  
  METHODS
  We searched articles published before June 6, 2014 from PubMed, CNKI, and Wanfang databases. Data were extracted from all eligible publications independently by two investigators and statistically analyzed. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the strength of the association between CCL5 polymorphism and TB.
  
  
  RESULTS
  Four case-control studies including 647 TB cases and 726 controls were involved in the meta-analysis. Our meta-analysis indicated the CCL5 -28C>G gene polymorphism was significantly associated with increased risk of TB (G vs. C: 3.75, 95% CI = 1.76-7.99; GG vs. CC: OR = 30.26, 95% CI = 14.28-64.12).
  
  
  CONCLUSIONS
  Our results suggested that the -28C>G polymorphism is significantly associated with higher TB risk, which is opposite from previously published reports. However, the number of the study is limited, additional well-designed studies are required to elucidate the association between the CCL5 -28C>G gene polymorphism and TB.
authors.affiliation: Department of Radiation Oncology, Peking University 3rd Hospital Haidian District, Beijing 100191, People's Republic of China ; Department of Medical Immunology, School of Medicine, Anhui University of Science and Technology Huainan 232001, Anhui, China.
authors.forename: Lelin
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Oncology, Teng Zhou Central People's Hospital Affiliated to Jining Medical College Teng Zhou 277599, Shandong, China.
authors.forename: Kaixian
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Peking University 3rd Hospital Haidian District, Beijing 100191, People's Republic of China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Yao
authors.affiliation: Department of Radiation Oncology, Peking University 3rd Hospital Haidian District, Beijing 100191, People's Republic of China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Wang
keywords: CCL5; TB; meta-analysis; polymorphism