title: Effect of CDKN2A/B rs4977756 polymorphism on glioma risk: a meta-analysis of 16 studies including 24077 participants.
abstract: So far, epidemiological studies have been performed to investigate the association of CDKN2A/B rs4977756 polymorphism and glioma risk. However, the results from different studies remain inconsistent. To clarify these conflicts and to quantitatively evaluate the effect of rs4977756 polymorphism on glioma risk, a meta-analysis was conducted using relevant published clinical studies about rs4977756 polymorphisms and glioma risk. Relevant studies concerning the association between rs4977756 polymorphism and risk of glioma were included in this meta-analysis. Odds ratio (OR) and 95 % confidence interval (CI) were calculated under fixed or random effects models when appropriate. Subgroup analyses were performed by race. This meta-analysis included 13 studies with a total of 8129 cases and 15,858 controls. The pooled results showed that there was an obvious association of CDKN2A/B rs4977756 polymorphism with risk of glioma in all four comparison models (dominant model/AG + GG vs. AA: OR = 1.36, 95 %CI = 1.20-1.54, p < 0.01; heterozygote comparison/AG vs. AA: OR = 1.31, 95 %CI = 1.12-1.53, p < 0.01; homozygote comparison/GG versus AA: OR = 1.49, 95 %CI = 1.36-1.64, p < 0.01; additive model/G vs. A: OR = 1.23, 95 %CI = 1.18-1.28, p < 0.01, respectively). For the subgroup analyses of ethnicities, similar results were observed in Caucasians. However, the association was not found between rs4977756 polymorphism and the risk of glioma in all models for the Asian studies. The CDKN2A/B rs4977756 polymorphism is obvious increase the risk of glioma in Caucasians. Future studies are needed to confirm the results in other ethnic populations.
authors.affiliation: Department of Neurosurgery, Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, 310016, China.
authors.forename: Xuchen
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Neurosurgery, Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, 310016, China.
authors.forename: Yingfeng
authors.initials: Y
authors.lastname: Wan
authors.affiliation: Department of Reproductive Endocrinology, Women's Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, 310006, China.
authors.forename: Qitao
authors.initials: Q
authors.lastname: Zhan
authors.affiliation: Department of Neurosurgery, Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, 310016, China.
authors.forename: Shuxu
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, 310016, China.
authors.forename: Yirong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, 310016, China. ccxiujun@163.com.
authors.forename: Xiujun
authors.initials: X
authors.lastname: Cai
mesh_terms: D044466:Asian People; D001932:Brain Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics*; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D006579:Heterozygote; D006801:Humans; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People
chemical_list: C493966:CDKN2B protein, human; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16
keywords: CDKN2A/CDKN2B; Glioma; Meta-analysis; rs4977756 polymorphism