title: The Non-Obese Diabetic Mouse Strain as a Model to Study CD8(+) T Cell Function in Relapsing and Progressive Multiple Sclerosis.
abstract: Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on central nervous system (CNS) myelin. Although CD4(+) T cell function in MS pathology has been extensively studied, there is also strong evidence that CD8(+) T lymphocytes play a key role. Intriguingly, CD8(+) T cells accumulate in great numbers in the CNS in progressive MS, a form of the disease that is refractory to current disease-modifying therapies that target the CD4(+) T cell response. Here, we discuss the function of CD8(+) T cells in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. In particular, we describe EAE in non-obese diabetic (NOD) background mice, which develop a pattern of disease characterized by multiple attacks and remissions followed by a progressively worsening phase. This is highly reminiscent of the pattern of disease observed in nearly half of MS patients. Particular attention is paid to a newly described transgenic mouse strain (1C6) on the NOD background whose CD4(+) and CD8(+) T cells are directed against the encephalitogenic peptide MOG[35-55]. Use of this model will give us a more complete picture of the role(s) played by distinct T cell subsets in CNS autoimmunity.
authors.affiliation: Department of Neurosciences, Centre de recherche du CHU de Québec - Université Laval (Pavillon CHUL) , Québec, QC , Canada.
authors.forename: Prenitha Mercy
authors.initials: PM
authors.lastname: Ignatius Arokia Doss
authors.affiliation: Department of Neurosciences, Centre de recherche du CHU de Québec - Université Laval (Pavillon CHUL) , Québec, QC , Canada.
authors.forename: Andrée-Pascale
authors.initials: AP
authors.lastname: Roy
authors.affiliation: Department of Neurosciences, Centre de recherche du CHU de Québec - Université Laval (Pavillon CHUL) , Québec, QC , Canada.
authors.forename: AiLi
authors.initials: A
authors.lastname: Wang
authors.affiliation: Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School , Boston, MA , USA ; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital and Harvard Medical School , Boston, MA , USA.
authors.forename: Ana Carrizosa
authors.initials: AC
authors.lastname: Anderson
authors.affiliation: Department of Neurosciences, Centre de recherche du CHU de Québec - Université Laval (Pavillon CHUL) , Québec, QC , Canada ; Department of Molecular Medicine, Faculty of Medicine, Université Laval , Québec, QC , Canada.
authors.forename: Manu
authors.initials: M
authors.lastname: Rangachari
keywords: 1C6; CD4+ T cell; CD8+ T cell; experimental autoimmune encephalomyelitis; multiple sclerosis; non-obese diabetic mouse; progressive multiple sclerosis; relapsing–remitting multiple sclerosis