title: Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3- trizole-4-carboxyl Amide Analogues.
abstract: Succinate dehydrogenase inhibitors (SDHIs) are fungicides with an amide bond widely used to control plant diseases caused by phytopathogenic fungi. Because of broad spectrum activity of new SDHIs, they have attracted wide attention from the research community. A series of structurally novel SDHIs with a bioactive 1,2,3-triazole moiety were designed and synthesized. Bioactivity screening showed that some of designed N-phenethyl-1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Sclerotinia sclerotiorum and Botrytis cinerea, while some of Nbenzyl- 1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Phytophthora capsici and Cercospora arachidicola. EC50 value of compound 5d against Cercospora arachidicola (6.6 µg/mL) was lower than that of chlorothalonil (12.3 µg/mL).
authors.forename: Zhen-Jun
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Tian
authors.affiliation: Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China. zwg@nankai.edu.cn.
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects*; D020171:Botrytis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010838:Phytophthora / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C000598934:5-methyl-1H-1,2,3-trizole-4-carboxyl amide; D000935:Antifungal Agents; D014230:Triazoles