title: The enteric microbiome in hepatobiliary health and disease.
abstract: Increasing evidence points to the contribution of the intestinal microbiome as a potentially key determinant in the initiation and/or progression of hepatobiliary disease. While current understanding of this dynamic is incomplete, exciting insights are continually being made and more are expected given the developments in molecular and high-throughput omics techniques. In this brief review, we provide a practical and updated synopsis of the interaction of the intestinal microbiome with the liver and its downstream impact on the initiation, progression and complications of hepatobiliary disease.
authors.affiliation: Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: James H
authors.initials: JH
authors.lastname: Tabibian
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Cyril
authors.initials: C
authors.lastname: Varghese
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Nicholas F
authors.initials: NF
authors.lastname: LaRusso
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Steven P
authors.initials: SP
authors.lastname: O'Hara
mesh_terms: D000818:Animals; D001659:Biliary Tract / Q000276:immunology / Q000382:microbiology*; D001660:Biliary Tract Diseases / Q000276:immunology / Q000382:microbiology*; D000069196:Gastrointestinal Microbiome; D006262:Health; D054884:Host-Pathogen Interactions; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology; D007422:Intestines / Q000382:microbiology*; D008099:Liver / Q000276:immunology / Q000382:microbiology*; D008107:Liver Diseases / Q000276:immunology / Q000382:microbiology*; D064307:Microbiota; D015398:Signal Transduction / Q000276:immunology
chemical_list: D018836:Inflammation Mediators
keywords: cholangiopathies; cirrhosis; liver diseases; microbiota; toll-like receptors