title: Gonadal Function and Fertility Among Survivors of Childhood Cancer.
abstract: Reproductive health and fertility are of great importance to the increasing number of survivors of childhood cancer, approximately 70% of whom are estimated to be over 20 years old. This article reviews the various treatment exposures that have been associated with makers of gonadal injury and decreased fertility in childhood cancer survivors. Identifying risk factors that decrease fertility is essential in proper counseling and timely referral for interventions that may allow for future fertility in high-risk populations.
authors.affiliation: Department of Pediatric Endocrinology, New York Presbyterian Hospital, Weill Cornell Medical College, 505 East 70 Street, New York, NY 10021, USA; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Antal
authors.affiliation: Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: sklarc@mskcc.org.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Sklar
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D002648:Child; D006801:Humans; D007246:Infertility / Q000139:chemically induced / Q000209:etiology; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects*; D017741:Survivors
chemical_list: D018906:Antineoplastic Agents, Alkylating
keywords: Chemotherapy; Childhood cancer survivor; Fertility; Gonadal injury; Infertility; Pregnancy; Radiation