title: The integration of autophagy and cellular trafficking pathways via RAB GAPs.
abstract: Macroautophagy is a conserved degradative pathway in which a double-membrane compartment sequesters cytoplasmic cargo and delivers the contents to lysosomes for degradation. Efficient formation and maturation of autophagic vesicles, so-called phagophores that are precursors to autophagosomes, and their subsequent trafficking to lysosomes relies on the activity of small RAB GTPases, which are essential factors of cellular vesicle transport systems. The activity of RAB GTPases is coordinated by upstream factors, which include guanine nucleotide exchange factors (RAB GEFs) and RAB GTPase activating proteins (RAB GAPs). A role in macroautophagy regulation for different TRE2-BUB2-CDC16 (TBC) domain-containing RAB GAPs has been established. Recently, however, a positive modulation of macroautophagy has also been demonstrated for the TBC domain-free RAB3GAP1/2, adding to the family of RAB GAPs that coordinate macroautophagy and additional cellular trafficking pathways.
authors.affiliation: a Institute for Pathobiochemistry; University Medical Center of the Johannes Gutenberg University ; Mainz , Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kern
authors.affiliation: b Buchmann Institute for Molecular Life Sciences; Goethe University Frankfurt ; Frankfurt am Main , Germany.
authors.forename: Ivan
authors.initials: I
authors.lastname: Dikic
authors.affiliation: a Institute for Pathobiochemistry; University Medical Center of the Johannes Gutenberg University ; Mainz , Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Behl
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology*; D020691:rab GTP-Binding Proteins / Q000378:metabolism
chemical_list: D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D020691:rab GTP-Binding Proteins
keywords: RAB GAP; RAB GTPase; RAB3GAP; autophagosome formation; autophagy; vesicle trafficking