title: The 18-kDa mitochondrial translocator protein in gliomas: from the bench to bedside.
abstract: The 18-kDa mitochondrial translocator protein (TSPO) is known to be highly expressed in several types of cancer, including gliomas, whereas expression in normal brain is low. TSPO functions in glioma are still incompletely understood. The TSPO can be quantified pre-operatively with molecular imaging making it an ideal candidate for personalized treatment of patient with glioma. Studies have proposed to exploit the TSPO as a transporter of chemotherapics to selectively target tumour cells in the brain. Our studies proved that positron emission tomography (PET)-imaging can contribute to predict progression of patients with glioma and that molecular imaging with TSPO-specific ligands is suitable to stratify patients in view of TSPO-targeted treatment. Finally, we proved that TSPO in gliomas is predominantly expressed by tumour cells.
authors.affiliation: Division of Brain Science, Wolfson Neuroscience Laboratories, Imperial College London, Du Cane Road, London W12 0NN, U.K.
authors.forename: Karolina
authors.initials: K
authors.lastname: Janczar
authors.affiliation: Wolfson Molecular Imaging Center, Institute of Brain, Behaviour and Mental Health, University of Manchester, 27 Palatine Road, Withington, Manchester M20 3LJ, U.K.
authors.forename: Zhangjie
authors.initials: Z
authors.lastname: Su
authors.affiliation: Division of Brain Science, Wolfson Neuroscience Laboratories, Imperial College London, Du Cane Road, London W12 0NN, U.K. Department of Health Sciences, University of Milan-Bicocca, Via Olgettina 60, 20132 Milano, Milan, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Raccagni
authors.affiliation: Division of Brain Science, Wolfson Neuroscience Laboratories, Imperial College London, Du Cane Road, London W12 0NN, U.K.
authors.forename: Andrea
authors.initials: A
authors.lastname: Anfosso
authors.affiliation: Department of Oncology, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, U.K.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Kelly
authors.affiliation: Division of Brain Science, Wolfson Neuroscience Laboratories, Imperial College London, Du Cane Road, London W12 0NN, U.K.
authors.forename: Pascal F
authors.initials: PF
authors.lastname: Durrenberger
authors.affiliation: Wolfson Molecular Imaging Center, Institute of Brain, Behaviour and Mental Health, University of Manchester, 27 Palatine Road, Withington, Manchester M20 3LJ, U.K.
authors.forename: Alexander
authors.initials: A
authors.lastname: Gerhard
authors.affiliation: Division of Brain Science, Wolfson Neuroscience Laboratories, Imperial College London, Du Cane Road, London W12 0NN, U.K. f.roncaroli@imperial.ac.uk.
authors.forename: Federico
authors.initials: F
authors.lastname: Roncaroli
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D058990:Molecular Targeted Therapy; D049268:Positron-Emission Tomography; D057285:Precision Medicine; D011379:Prognosis; D018079:Receptors, GABA / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D000970:Antineoplastic Agents; D018079:Receptors, GABA; C499229:TSPO protein, human
keywords: glioma; pathology; positron emission tomography (PET)-imaging; translocator protein