title: The Path to Cancer --Three Strikes and You're Out.
abstract: Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults, alterations in as few as three driver genes appear to suffice for a cell to evolve into an advanced cancer.
authors.affiliation: From the Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore.
authors.forename: Bert
authors.initials: B
authors.lastname: Vogelstein
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Kinzler
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics