title: Noble metals in oncology.
abstract: Worldwide research groups are searching for anticancer compounds, many of them are organometalic complexes having platinum group metals as their active centers. Most commonly used cytostatics from this group are cisplatin, carboplatin and oxaliplatin. Cisplatin was used fot the first time in 1978, from this time many platinum derivatives were created. In this review we present biological properties and probable future clinical use of platinum, gold, silver, iridium and ruthenium derivatives. Gold derivative Auranofin has been studied extensively. Action of silver nanoparticles on different cell lines was analysed. Iridium isotopes are commonly used in brachyterapy. Ruthenium compound new anti-tumour metastasis inhibitor (NAMI-A) is used in managing lung cancer metastases. Electroporation of another ruthenium based compound KP1339 was also studied. Most of described complexes have antiproliferative and proapoptotic properties. Further studies need to be made. Nevertheless noble metal based chemotherapheutics and compounds seem to be an interesting direction of research.
authors.affiliation: Perinatology and Gynecology Department, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Markowska
authors.affiliation: University Hospital of Lord's Transfiguration, Poznan, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Kasprzak
authors.affiliation: University Hospital of Lord's Transfiguration, Poznan, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Jaszczyńska-Nowinka
authors.affiliation: University Hospital of Lord's Transfiguration, Poznan, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lubin
authors.affiliation: Division of Gynecology, Department of Oncology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Janina
authors.initials: J
authors.lastname: Markowska
keywords: gold; noble metals; platinum; silver