title: Functional characteristics of the growth factor receptor family and some ligands in the oropharyngeal cavity of the Chukar partridge (Alectoris chukar).
abstract: 1. The aim of the present study is to describe, immunohistochemically, the expression and cell type localisation of growth factor receptors and some of their ligands in the oropharyngeal organs of the Chukar partridge. 2. The tissue samples from 10 healthy adult partridges were dissected under ether anaesthesia and then embedded in paraffin following routine histological procedures. The immunoreaction for receptors and ligands of the epidermal growth factor receptor (EGFR)/ligand system was localised in the cell membrane, nucleus and cytoplasm of the luminal and glandular epithelial cells, stromal and striated muscle cells, and vascular endothelial and smooth muscle cells. 3. Variations were observed in the avian oropharyngeal organs. The immunostaining for the erbB1/HER1 (human epidermal growth factor receptor 1) and the EGF (epidermal growth factor) and AREG (Amphiregulin) ligands in the luminal epithelial cells was higher than in the glandular epithelial, stromal and striated muscle cells. However, the immunostaining for erbB3/HER3 (human epidermal growth factor receptor 3) and erbB4/HER4 (human epidermal growth factor receptor 4) were similar in the luminal epithelium, stromal and striated muscle cells. 4. Growth factor receptors and some of their ligands were localised in different cell types in the oropharyngeal organs. We suggest that erbB/HERs (human epidermal growth factor receptors) and their ligands play an important role in proliferation, differentiation, growth, survival and migration of the cells.
authors.affiliation: a Department of Histology and Embryology, Faculty of Veterinary Medicine , Dicle University , Diyarbakir , Turkey.
authors.forename: Berna G
authors.initials: BG
authors.lastname: Saruhan
authors.affiliation: a Department of Histology and Embryology, Faculty of Veterinary Medicine , Dicle University , Diyarbakir , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Sağsöz
authors.affiliation: a Department of Histology and Embryology, Faculty of Veterinary Medicine , Dicle University , Diyarbakir , Turkey.
authors.forename: Mehmet E
authors.initials: ME
authors.lastname: Akbalik
authors.affiliation: b Department of Anatomy, Faculty of Veterinary Medicine , Namık Kemal University , Tekirdağ , Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Erdoğan
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000235:genetics* / Q000378:metabolism; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D005260:Female; D046094:Galliformes / Q000235:genetics* / Q000378:metabolism; D008024:Ligands; D008297:Male; D009928:Organ Specificity; D009960:Oropharynx / Q000378:metabolism
chemical_list: D030161:Avian Proteins; D008024:Ligands; D066246:ErbB Receptors