title: CD4+CD25+ cells in multiple myeloma related renal impairment.
abstract: CD4(+)CD25(+) cells are critical regulators in almost all of the animal models of human organ-specific autoimmune diseases, transplant rejection and allergic diseases. We aimed to explore the role of CD4(+)CD25(+) cells in the pathogenesis of multiple myeloma (MM) related renal impairment (RI). Thirty patients with MM related RI and 30 healthy volunteers were studied. The number of CD4(+)CD25(+) cells was examined by flow cytometry. Clinical and laboratory data were collected from each subject. Glomerular injury was assessed by histopathology. Serum IL-2, IL-4 and IL-6 were analyzed by ELISA. CD4(+)CD25(+) cells significantly decreased in MM related RI patients compared to the controls (P<0.05). CD4(+)CD25(+) cell number was negatively associated with blood urea nitrogen (BUN), supernatant IL-4, serum IL-6, monoclonal immunoglobulin and β2-microglobulin, as well as bone marrow plasma cell percentage and proteinuria; whereas positively associated with estimated glomerular filtration rate (eGFR) (all P < 0.05). CD4(+)CD25(+) cells gradually decreased as the Clinic Stage increased. The number of CD4(+)CD25(+) cells reduced in MM related RI patients, and was correlated with disease severity. CD4(+)CD25(+) cells may play an important role in the pathogenesis of MM related RI.
authors.affiliation: Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, P.R. China.|Division of Nephrology, Hunan Normal University, Hunan Provincial People's Hospital of China, Changsha, P.R. China.
authors.forename: Hongdong
authors.initials: H
authors.lastname: Huang
authors.affiliation: Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Division of Nephrology, Hunan Normal University, Hunan Provincial People's Hospital of China, Changsha, P.R. China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Liver Surgery, the Affiliated Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
authors.forename: Xi-Dai
authors.initials: XD
authors.lastname: Long
authors.affiliation: Hunan Key Laboratory of Nephrology and Hemoperfusion, Division of Nephrology, Second Xiangya Hospital of Central South University, Changsha, Hunan Province, P.R. China.
authors.forename: Youming
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, P.R. China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, P.R. China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Wen
authors.affiliation: Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Jia
authors.affiliation: Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, P.R. China.
authors.forename: Ru
authors.initials: R
authors.lastname: Tian
authors.affiliation: Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, P.R. China.
authors.forename: Chengli
authors.initials: C
authors.lastname: Bai
authors.affiliation: Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, P.R. China.
authors.forename: Cui
authors.initials: C
authors.lastname: Li
authors.affiliation: Section of Hematology/Oncology, Section of Gastroenterology, Stephenson Cancer Center, Department of Internal Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, USA.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D001806:Blood Urea Nitrogen; D002478:Cells, Cultured; D005260:Female; D005434:Flow Cytometry; D005919:Glomerular Filtration Rate; D006801:Humans; D007376:Interleukin-2 / Q000097:blood / Q000276:immunology; D015847:Interleukin-4 / Q000097:blood / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D007668:Kidney / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000150:complications / Q000276:immunology*; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6; D015847:Interleukin-4