title: Prevalence of Diabetes Mellitus (DM) in a population of men affected by Erectile Dysfunction (ED).
abstract: OBJECTIVE
  A) to evaluate the prevalence of patients affected by Diabetes Mellitus (DM) in a population of men with Erectile Dysfunction (ED); B) to define the epidemiological, biochemical and therapeutic aspects.
  
  
  METHODS
  N.934 subjects referred at our Andrology Unit for ED were studied. The diagnosis of ED was evaluated using the IIEF-5 questionnaire (Total score ≤21).
  
  
  RESULTS
  The prevalence of subjects affected by DM in a population of men with ED was 19.5% (182/934). The age ranges were: ≥55 years (108/182; 59.3%); ≥40<55 years (70/182; 38.5%); <40 years (4/182; 2.2%). HbA1c mean value was 7.9% ± 0.8%. No significant differences were found in DM onset timing or in anti-diabetic treatment. In n.125/182 cases (68.7%) the ED onset followed the diagnosis of DM; in n.34/182 cases (18.7%) it appeared at the same time; and in n.23/182 cases (12.6%) appeared before DM diagnosis.
  in n.18/182 subjects (9.9%) there was a concomitant hypotestosteronemia; these patients were treated only with testosterone replacement; this treatment was efficacious (IIEF-5 total score ≥22) in 8/18 subjects (44.4%). In n.146/182 subjects (80.2%) a treatment with PDE5-i was given. Of these 146 subjects, the therapy was given "on demand" to 108 subjects (efficacy in 50.9%; 55/108) and "once a day" to the remaining 38 subjects (efficacy 63.1%, 24/38) (p=0.428, n.s.). N.15/182 subjects (8.2%) were treated with intracavernous injections of Alprostadil (efficacy in 8/15, 53.3%). In n.3/182 subjects (1.6%) a penile prosthesis was implanted.
  
  
  CONCLUSIONS
  DM is one of the most frequent organic causes of ED; there were many strategies to treat this symptom without interfering with the antidiabetic treatment. Finally, ED can be predictive of DM.
authors.affiliation: Department of Clinical and Molecular Medicine. Sant'Andrea Hospital, Unit of Andrology, University of Rome "Sapienza", Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Mazzilli
authors.affiliation: Department of Clinical and Molecular Medicine. Sant'Andrea Hospital, Unit of Andrology, University of Rome "Sapienza", Rome, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Elia
authors.affiliation: Department of Clinical and Molecular Medicine. Sant'Andrea Hospital, Unit of Andrology, University of Rome "Sapienza", Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Delfino
authors.affiliation: Department of Clinical and Molecular Medicine. Sant'Andrea Hospital, Unit of Andrology, University of Rome "Sapienza", Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Benedetti
authors.affiliation: Department of Clinical and Molecular Medicine. Sant'Andrea Hospital, Unit of Andrology, University of Rome "Sapienza", Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Scordovillo
authors.affiliation: Department of Clinical and Molecular Medicine. Sant'Andrea Hospital, Unit of Andrology, University of Rome "Sapienza", Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Mazzilli
mesh_terms: D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000453:epidemiology*; D007172:Erectile Dysfunction / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology*; D020249:Hormone Replacement Therapy; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use
chemical_list: D013739:Testosterone
keywords: Diabetes mellitus; Erectile dysfunction; IIEF-5; PDE5-i