title: Analysis of the Oxidative Stress Status in Nonspecific Vaginitis and Its Role in Vaginal Epithelial Cells Apoptosis.
abstract: Nonspecific vaginitis (NSV), also named bacterial vaginosis, is one of the most common genital system diseases in women during their reproductive years. The specific pathogenic mechanism of NSV is not clear yet. Upon the balance alteration, large amount of reactive oxidant species (ROS) is generated and accumulated in the genital tract, and thus resulting in oxidative stress, which has been reported to be an important trigger of mitochondrial pathway cell apoptosis. In this study, the antioxidant secretion level and antioxidant enzyme activity in the vaginal discharge were evaluated to analyze the oxidative status in the vaginal tract of NSV patients. The effect of oxidative stress on the vaginal mucosa epithelial cell apoptosis was then studied. The role of oxidative stress on NSV development was uncovered; thus open new direction for the prevention and treatment of NSV by providing antiradical agents was revealed.
authors.affiliation: Department of Gynaecology, Linyi People's Hospital, Linyi, Shandong 276000, China.
authors.forename: Zhaojie
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Gynaecology, Linyi People's Hospital, Linyi, Shandong 276000, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Gynaecology, Linyi People's Hospital, Linyi, Shandong 276000, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Gynaecology, Linyi People's Hospital, Linyi, Shandong 276000, China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Xie
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000032:analysis / Q000378:metabolism; D002470:Cell Survival / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology; D005260:Female; D006801:Humans; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D014621:Vagina / Q000166:cytology* / Q000503:physiopathology; D016585:Vaginosis, Bacterial / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D051017:Apoptosis Regulatory Proteins