title: [Visual acuity, pachymetry and corneal density after 5% sodium chloride treatment in corneal edema after surgery].
abstract: OBJECTIVE
  To evaluate the effectiveness of a hyperosmolar medication in corneal edema.
  
  
  METHODS
  This was a prospective randomized study, performed in patients with post-operative corneal edema. Two groups were created: group 1 treated with hypertonic eye drops of 5% sodium chloride with 0.15% sodium hyaluronate in addition to the usual post-operative treatment for 1 month; group 2 without treatment for edema. Visual acuity, pachymetry and corneal density were measured at 1 day, 1 week, 1 month, 3 months and 6 months following surgery.
  
  
  RESULTS
  Forty-four patients were included in group 1 and 42 in group 2. Visual acuity was significantly better in group 1 than in group 2 at 7 days (0.84 logMAR vs 1.55 logMAR, P=0.019 CI 95% [-1.298;-0.128]) and was no longer different at one month, three and six months. Pachymetry decreased significantly in 7 days in group 1 (decrease of 17%, P=0.04, CI 95% [1.987; 258.305]), compared to group 2 (P=0.8, CI 95% [-132.9; 161.8]), but the difference between the 2 groups was not statistically significant (P=0.11, CI 95% [-16; 19.1]). Corneal density was also not significantly different between the two groups.
  
  
  CONCLUSIONS
  Five percent sodium chloride hypertonic eye drops show a statistically significant reduction in post-operative corneal edema as shown by the improvement in visual acuity at one week and the downward trend in pachymetry.
authors.affiliation: Service d'ophtalmologie, université d'Aix-Marseille, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France; Équipe DiMABio, faculté des sciences de Saint-Jérôme, université d'Aix-Marseille, institut Fresnel, avenue Escadrille Normandie-Niemen, 13397 Marseille cedex, France. Electronic address: gaelle-howangyin@hotmail.fr.
authors.forename: G
authors.initials: G
authors.lastname: Ho Wang Yin
authors.affiliation: Service d'ophtalmologie, université d'Aix-Marseille, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
authors.forename: M
authors.initials: M
authors.lastname: Sampo
authors.affiliation: Service d'ophtalmologie, université d'Aix-Marseille, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
authors.forename: S
authors.initials: S
authors.lastname: Soare
authors.affiliation: Service d'ophtalmologie, université d'Aix-Marseille, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
authors.forename: L
authors.initials: L
authors.lastname: Hoffart
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015715:Corneal Edema / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D063171:Corneal Pachymetry; D003720:Densitometry; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D011446:Prospective Studies; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D012462:Saline Solution, Hypertonic; D006820:Hyaluronic Acid
keywords: Acuité visuelle; Corneal densitometry; Corneal edema; Densitométrie; Hyperosmolar eye drops; Pachymetry; Pachymétrie; Solution hyperosmolaire; Visual acuity; Œdème de cornée