title: The 'Omics' of Voluntary Exercise: Systems Approaches to a Complex Phenotype.
abstract: Predisposition to engage in exercise is highly variable and simultaneously influenced by the environment, complex genomics, and their interactions. Given the importance of exercise to health, understanding the underlying influences of variability is crucial. Here, we discuss murine systems approaches, focusing on 'omics', relevant to revealing the architecture of voluntary activity.
authors.affiliation: Department of Zoology, Ohio Wesleyan University, Delaware, OH 43015, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Kelly
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Fernando Pardo-Manuel de
authors.initials: FP
authors.lastname: Villena
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: dpomp@unc.edu.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pomp
mesh_terms: D000818:Animals; D004777:Environment; D015444:Exercise / Q000502:physiology*; D023281:Genomics; D006801:Humans; D010641:Phenotype; D010805:Physical Conditioning, Animal / Q000502:physiology*; D040901:Proteomics
keywords: Collaborative Cross; Diversity Outbred; genomics; proteomics; transcriptomics; wheel running