title: Natural products against hematological malignancies and identification of their targets.
abstract: Naturally occurring molecules derived from higher plants, animals, microorganisms and minerals play an important role in the discovery and development of novel therapeutic agents. The identification of molecular targets is of interest to elucidate the mode of action of these compounds, and it may be employed to set up target-based assays and allow structure-activity relationship studies to guide medicinal chemistry efforts toward lead optimization. In recent years, plant-derived natural compounds possessing potential anti-tumor activities have been garnering much interest and efforts are underway to identify their molecular targets. Here, we attempt to summarize the discoveries of several natural compounds with activities against hematological malignancies, such as adenanthin, oridonin, gambogic acid and wogonoside, the identification of their targets, and their modes of actions.
authors.affiliation: Department of Pathophysiology, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.|Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences-Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Respiratory Disease, Protein Modification and Degradation Lab, Department of Pathophysiology, Guangzhou Medical University, Guangdong, 510182, China.
authors.forename: JinBao
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathophysiology, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
authors.forename: YingLi
authors.initials: Y
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 211198, China.
authors.forename: QingLong
authors.initials: Q
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.
authors.forename: HanDong
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Pathophysiology, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. chengq@shsmu.edu.cn.|Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences-Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. chengq@shsmu.edu.cn.
authors.forename: GuoQiang
authors.initials: G
authors.lastname: Chen
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000627:therapeutic use*; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000627:therapeutic use; D044950:Flavanones / Q000737:chemistry / Q000627:therapeutic use; D005960:Glucosides / Q000737:chemistry / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D058990:Molecular Targeted Therapy / Q000379:methods* / Q000639:trends; D008517:Phytotherapy / Q000379:methods* / Q000639:trends; D044004:Xanthones / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D001688:Biological Products; D045786:Diterpenes, Kaurane; D044950:Flavanones; D005960:Glucosides; D044004:Xanthones; C000600164:adenanthin; C011959:oridonin; C052659:gambogic acid; C473995:wogonoside
keywords: adenanthin; hematological malignancies; natural products; target identification