title: Characterization of biodegradable poly-3-hydroxybutyrate films and pellets loaded with the fungicide tebuconazole.
abstract: Biodegradable polymer poly(3-hydroxybutyrate) (P3HB) has been used as a matrix to construct slow-release formulations of the fungicide tebuconazole (TEB). P3HB/TEB systems constructed as films and pellets have been studied using differential scanning calorimetry, X-ray structure analysis, and Fourier transform infrared spectroscopy. TEB release from the experimental formulations has been studied in aqueous and soil laboratory systems. In the soil with known composition of microbial community, polymer was degraded, and TEB release after 35 days reached 60 and 36 % from films and pellets, respectively. That was 1.23 and 1.8 times more than the amount released to the water after 60 days in a sterile aqueous system. Incubation of P3HB/TEB films and pellets in the soil stimulated development of P3HB-degrading microorganisms of the genera Pseudomonas, Stenotrophomonas, Variovorax, and Streptomyces. Experiments with phytopathogenic fungi F. moniliforme and F. solani showed that the experimental P3HB/TEB formulations had antifungal activity comparable with that of free TEB.
authors.affiliation: Institute of Biophysics SB RAS, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation. volova45@mail.ru.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Volova
authors.affiliation: Institute of Biophysics SB RAS, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation.
authors.forename: Natalia
authors.initials: N
authors.lastname: Zhila
authors.affiliation: Institute of Biophysics SB RAS, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation.
authors.forename: Olga
authors.initials: O
authors.lastname: Vinogradova
authors.affiliation: Institute of Biophysics SB RAS, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation.
authors.forename: Anna
authors.initials: A
authors.lastname: Shumilova
authors.affiliation: Institute of Biophysics SB RAS, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Prudnikova
authors.affiliation: Institute of Biophysics SB RAS, 50/50 Akademgorodok, Krasnoyarsk, 660036, Russian Federation.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Shishatskaya
mesh_terms: D002152:Calorimetry, Differential Scanning; D005659:Fungicides, Industrial / Q000032:analysis / Q000737:chemistry; D006885:Hydroxybutyrates / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D012987:Soil / Q000737:chemistry; D014230:Triazoles / Q000032:analysis / Q000737:chemistry; D000094122:Polyhydroxybutyrates
chemical_list: D005659:Fungicides, Industrial; D006885:Hydroxybutyrates; D011091:Polyesters; D012987:Soil; D014230:Triazoles; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates; C087114:tebuconazole
keywords: Antifungal activity; Controlled release; Poly(3-hydroxybutyrate); Slow-release formulations; Tebuconazole