title: Microcrystalline cellulose-carboxymethyl cellulose sodium as an effective dispersant for drug nanocrystals: A case study.
abstract: This study is aimed at seeking an alternative dispersant for spray drying of drug nanosuspensions. The ideal dispersant is not only able to prevent the agglomeration of drug nanocrystals in the suspension state, but also it is able to preserve redispersibility of drug nanocrystals after drying. An active pharmaceutical ingredient (API) was used as a model drug. API nanosuspensions were prepared by homogenization and converted into nanocrystals powder (API-NP) with microcrystalline cellulose-carboxymethyl cellulose sodium (MCCS) via spray drying. It was found that MCCS was able to prevent the aggregation of API-NP in the suspension state and the agglomeration during spray-drying process, possibility due to its high Zeta potential and steric barrier from network structure, and reduction of API size at nanoscale and incorporation into MCCS network structure did not affect the solid state of API as evidenced by DSC and XRD analysis. The spray-dried API-NP/MCCS powders exhibited excellent sphere-shape performance, and could easily redispersed to API-NC suspensions state. Dissolution of the spray-dried API-NP was distinctly superior to those of the crude powder and physical mixture, respectively. Within 30 min, approximate 85.87% of API was dissolved from the API-NP/MCCS. MCCS was demonstrated to be an effective dispersant for spray-dried drug nanocrystals and preservation of the nanocrystals associated with excellent redispersibility.
authors.affiliation: Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
authors.forename: JiXiu
authors.initials: J
authors.lastname: Dan
authors.affiliation: Department of Pharmaceutics, 94th Hospital of People's Liberation Army, Nanchang, China.
authors.forename: YueQin
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China. Electronic address: feigleYue@outlook.com.
authors.forename: PengFei
authors.initials: P
authors.lastname: Yue
authors.affiliation: Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
authors.forename: YuanBiao
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
authors.forename: PengYi
authors.initials: P
authors.lastname: Hu
authors.affiliation: Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
authors.forename: WeiFeng
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
mesh_terms: D000336:Aerosols / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D003890:Desiccation; D004337:Drug Carriers / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000336:Aerosols; D004337:Drug Carriers; D002482:Cellulose; D002266:Carboxymethylcellulose Sodium; C109691:microcrystalline cellulose
keywords: Microcrystalline cellulose-carboxymethyl cellulose sodium; Nanocrystals; Redispersibility; Spray-drying