title: Clinicopathologic Features of Gastric Schwannoma: 8-Year Experience at a Single Institution in China.
abstract: To explore the clinicopathologic characteristics, diagnosis, treatment, and prognosis of gastric schwannoma in the imatinib era.The clinicopathologic characteristics and postoperative outcomes of patients diagnosed with gastric schwannoma at our institution between January 2007 and February 2015 were retrospectively collected and analyzed.The main patient complaint was epigastric pain or discomfort. Tumor sizes ranged from 15 to 80 mm (mean, 57.1 mm). In 17 patients, the tumors were located in the body of the stomach. A total of 20 patients were preoperatively misdiagnosed with a gastrointestinal stromal tumor. The rate of correct preoperative diagnosis was only 3.3%. All patients underwent surgical resection and showed strong S-100 protein positivity. Laparoscopic surgery for gastric schwannoma was associated with less blood loss and a shorter postoperative hospital stay than open surgery (P < 0.01). Total 28 patients were disease free without recurrence or metastasis at a median follow-up time of 50 months.Gastric schwannoma is often preoperatively misdiagnosed as gastric gastrointestinal stromal tumor. Laparoscopic resection of gastric schwannoma is considered safe and effective, and it may be the preferred surgery for most small- and moderate-sized tumors. The long-term outcome is excellent, as this type of neoplasm is uniformly benign.
authors.affiliation: From the Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Kaixiong
authors.initials: K
authors.lastname: Tao
authors.forename: Weilong
authors.initials: W
authors.lastname: Chang
authors.forename: Ende
authors.initials: E
authors.lastname: Zhao
authors.forename: Rui
authors.initials: R
authors.lastname: Deng
authors.forename: Jinbo
authors.initials: J
authors.lastname: Gao
authors.forename: Kailin
authors.initials: K
authors.lastname: Cai
authors.forename: Guobin
authors.initials: G
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000473:pathology* / Q000601:surgery; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery