title: The role of human metapneumovirus in the critically ill adult patient.
abstract: OBJECTIVE
  The purpose of the study is to describe the role of human metapneumovirus (hMPV) infection in critical illness and acute respiratory distress syndrome (ARDS).
  
  
  METHODS
  We collected clinical and demographic information from a retrospective chart review, comparing patients with and without an intensive care unit (ICU) admission. Among patients admitted to the ICU, we assessed whether hMPV was "unlikely," "possibly," or "likely" the reason for ICU admission, based on a prespecified definition, and whether the patient met criteria for ARDS.
  
  
  RESULTS
  We identified 128 hospitalized adults with hMPV infection. Forty hospitalized patients (31%) with hMPV infection required admission to the ICU. Among patients cared for in the ICU, hMPV was "possibly" the reason for ICU admission in 55% of patients and "likely" the reason in 38%. Forty-eight percent of ICU patients met criteria for ARDS. Although most patients admitted to the ICU had significant comorbidities or were immunosuppressed, 6 patients requiring ICU admission had more minor comorbidities and no underlying immunosuppression.
  
  
  CONCLUSIONS
  Although most patients hospitalized with hMPV had chronic cardiac or pulmonary disease, hMPV can also be associated serious respiratory illness and ARDS in adult patients without significant comorbidities or immunosuppression.
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI. Electronic address: hasvold@gmail.com.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hasvold
authors.affiliation: Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
authors.forename: Michael
authors.initials: M
authors.lastname: Sjoding
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
authors.forename: Kyle
authors.initials: K
authors.lastname: Pohl
authors.affiliation: Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI; Center for Healthcare Outcomes & Policy, Institute for Healthcare Innovation & Policy, University of Michigan, Ann Arbor, MI.
authors.forename: Colin
authors.initials: C
authors.lastname: Cooke
authors.affiliation: Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Hyzy
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000453:epidemiology; D015897:Comorbidity; D003422:Critical Care; D016638:Critical Illness / Q000453:epidemiology*; D005260:Female; D006331:Heart Diseases / Q000453:epidemiology; D006333:Heart Failure / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008171:Lung Diseases / Q000453:epidemiology; D008297:Male; D029121:Metapneumovirus / Q000235:genetics; D008875:Middle Aged; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000821:virology; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology; D012128:Respiratory Distress Syndrome / Q000453:epidemiology* / Q000821:virology; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction
keywords: ARDS; Viral pneumonia