title: Preparation of hybrid materials for controlled drug release.
abstract: Authors obtained hybrid organic-inorganic materials applied in sustained drug delivery. The materials are ibuprofen as a model drug, hydroxyapatite and three different polymers as supports. Influence of the type of employed polymer, an inorganic carrier, on the properties and drug release profiles was estimated. Flory-Huggins interaction parameters, the dispersive component of surface free energy and acid-base characteristic of the surface were used to assess the behavior of the composites in terms of drug release. The experiments were carried out with the use of inverse gas chromatography (IGC), Fourier transform infrared (FTIR) and ultraviolet (UV) techniques. FTIR and ATR-FTIR spectra were collected. The values of [Formula: see text] parameter obtained for all investigated materials (excluding poly(L-lactide) (PLA2)) indicate low or medium activity. The strongest interactions (the lowest values of the Flory-Huggins [Formula: see text] parameter) are observed for PLA2 composition, while the weakest interactions for systems with polyethylene glycol (PEG). Finally, drug release profiles are shown. For materials prepared with Eudragit® (EUD) and PLA, the release of drug was much smaller, which corresponds to lower values of Flory-Huggins parameter. The executed experiments allowed the estimation of the properties of prepared composites. Prepared materials present properties required in sustained drug release and may be successfully applied as drug delivery systems.
authors.affiliation: a Institute of Chemical Technology and Engineering, Poznan University of Technology , Ul. Berdychowo 4 , Poznań , Poland.
authors.forename: Kasylda
authors.initials: K
authors.lastname: Milczewska
authors.affiliation: a Institute of Chemical Technology and Engineering, Poznan University of Technology , Ul. Berdychowo 4 , Poznań , Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Voelkel
authors.affiliation: a Institute of Chemical Technology and Engineering, Poznan University of Technology , Ul. Berdychowo 4 , Poznań , Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Zwolińska
authors.affiliation: a Institute of Chemical Technology and Engineering, Poznan University of Technology , Ul. Berdychowo 4 , Poznań , Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Jędro
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002849:Chromatography, Gas; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D017886:Durapatite / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D011092:Polyethylene Glycols; C033616:poly(lactide); D017886:Durapatite; D007052:Ibuprofen
keywords: Controlled drug delivery; Flory–Huggins interaction parameters; hybrid materials; inverse gas chromatography