title: Associations between the codon 72 polymorphism of the TP53 gene and the risk of recurrent implantation failure.
abstract: OBJECTIVE
  Recurrent implantation failure (RIF) is the most common cause of unsuccessful pregnancy after assisted reproductive techniques. The tumor protein P53 (TP53) codon 72 polymorphism (G-C transversion) has been explored in susceptibility to RIF, but inconclusive results have been reported. The aim of this article is to estimate the associations between the TP53 codon 72 polymorphism and the risk of RIF.
  
  
  METHODS
  A comprehensive search for relevant articles was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for CC + GC versus GG, CC versus GC + GG, CC versus GG, GC versus GG genotypes, and C versus G allele, were estimated. Publication bias was explored. Statistical analyses were performed using RevMan 5.2 and Stata 11.0 software.
  
  
  RESULTS
  A total of five case-control studies in five articles with 417 RIF cases and 325 controls were included. An overall random effect OR of 1.20 (95% CI, 0.66-2.19; P = 0.55) in the dominant model (CC + GC vs GG) was found. The results suggested that a lack of increased or decreased risks were found in individuals who carried the CC homozygote and heterozygote GC, in comparison with the homozygote GG. However, in subgroup analysis by ethnicity, a significantly increased risk was observed among Latin Americans in the dominant model (OR, 1.56; 95% CI, 1.04-2.33; P = 0.03).
  
  
  CONCLUSIONS
  This meta-analysis shows that the TP53 codon 72 polymorphism is not associated with RIF risk in the overall population; however, associations were found in the Latin American population.
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.|West China School of Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Gynecology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Wu
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.|West China School of Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Lin
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.|West China School of Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Gynecology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China.
authors.forename: Zhi-Juan
authors.initials: ZJ
authors.lastname: Luo
authors.affiliation: Department of Gynecology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China.
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Zhou
authors.affiliation: Department of Gynecology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Gynecology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Gynecology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China.|National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.|West China School of Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.|The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R.China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
mesh_terms: D016022:Case-Control Studies; D003062:Codon; D010064:Embryo Implantation / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53
keywords: TP53; meta-analysis; polymorphism; recurrent implantation failure