title: Clinical observation of docetaxel or gemcitabine combined with cisplatin in the chemotherapy after surgery for stage II-III non-small cell lung cancer.
abstract: OBJECTIVE
  This study aimed to compare the efficacy and toxicity of docetaxel combined with cisplatin (DP) and gemcitabine combined with cisplatin (GP) in postoperative chemotherapy after surgery of non-small cell lung cancer (NSCLC).
  
  
  METHODS
  A total of 92 patients diagnosed with NSCLC after surgery were enrolled, and they were treated with DP (DP group) and GP (GP group). The efficacy and toxicity of the medications were then compared.
  
  
  RESULTS
  Approximately 92.4% (85 out of 92) of the patients received chemotherapy for more than three weeks. In the DP and GP groups, the incidence rates of grade III-IV thrombocytopenia were 24.4% and 6.38%, respectively, whereas the incidence rates of alopecia were 88.9% and 25.5%, respectively. The difference between the two groups was statistically significant (p < 0.05). Disease-free survival rates in DP group in one and two years were 76.5% and 50.47%, respectively, whereas in the GP group they were 77.8% and 49.52%, respectively. No significant difference was observed between the two groups (p > 0.05).
  
  
  CONCLUSIONS
  These results showed similar disease-free survival rates of DP and GP therapies in one and two years after surgery for NSCLC. However, the DP group exhibited higher incidence rates of grade III-IV thrombocytopenia and alopecia than the GP group. Therefore, we should select a specific treatment for each patient according to individual differences.
authors.affiliation: Department of Thoracic Surgery, the directly affiliated hospital of Huzhou Teachers College, Huzhou, Zhejiang, PR China.
authors.forename: Qiu-Qiang
authors.initials: QQ
authors.lastname: Chen
authors.affiliation: Department of Pathology, People's Hospital of Deqing County, Wukang, Zhejiang, PR China.
authors.forename: Xue-Xian
authors.initials: XX
authors.lastname: Ji
authors.affiliation: Department of Respiratory Medicine, the directly affiliated hospital of Huzhou Teachers College, Huzhou, Zhejiang, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Pathology, the directly affiliated hospital of Huzhou Teachers College, Huzhou, Zhejiang, PR China.
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Shi
authors.affiliation: Department of Thoracic Surgery, the directly affiliated hospital of Huzhou Teachers College, Huzhou, Zhejiang, PR China.
authors.forename: Huan-Ming
authors.initials: HM
authors.lastname: Yu
authors.affiliation: Department of Respiratory Medicine, the directly affiliated hospital of Huzhou Teachers College, Huzhou, Zhejiang, PR China.
authors.forename: Heng-Qin
authors.initials: HQ
authors.lastname: Fu
authors.affiliation: Department of Respiratory Medicine, People's Hospital of Deqing County, Wukang, Zhejiang, PR China.
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Ji
keywords: NSCLC; cisplatin; docetaxel; gemcitabine; postoperative chemotherapy