title: Causes of endogenous uveitis in cats presented to referral clinics in North Carolina.
abstract: OBJECTIVE
  To investigate the causes of endogenous uveitis in cats presenting to referral ophthalmology clinics in North Carolina.
  
  
  METHODS
  Medical records of cats diagnosed with endogenous uveitis at North Carolina State University's College of Veterinary Medicine (NCSU-CVM) or Animal Eye Care Associates of Cary, NC between 2003 and 2015 were reviewed. Inclusion criteria were cats that had complete diagnostic workups, including clinical, clinicopathological, serological, and histopathological data, as well as imaging modalities. Serology was consistently completed for feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), feline coronavirus (FCoV), Toxoplasma gondii, and Bartonella spp.
  
  
  RESULTS
  One hundred and twenty cats met the inclusion criteria. Seroprevalence of FeLV (2.7%), FIV (7.3%), FCoV (34.7%), T. gondii (23.7%), and Bartonella spp. (43.2%) was observed, with a combined seroprevalence of 59.2%. Nineteen cats (15.8%) were diagnosed with feline infectious peritonitis (FIP) based on clinical, hematological, serological, histopathological, and necropsy findings. The average age of all cases was 7.62 years, while the average age of cats diagnosed with FIP was 1.82 years. Neoplasia was diagnosed in six cats (5.0%). No underlying etiology was found in 49 cats (40.8%).
  
  
  CONCLUSIONS
  Both idiopathic and neoplastic causes of uveitis were less prevalent than previously reported in studies, while seropositivity was higher than previously reported for the study area. This may be due to improved diagnostic capabilities or that cats with infectious disease were more likely to be referred. Because of the high prevalence of FIP, young cats with uveitis should be evaluated for hyperglobulinemia and FCoV serology should be performed as minimal diagnostics.
authors.affiliation: College of Veterinary Medicine, NCSU-CVM, Clinical Sciences, Raleigh, NC, USA.
authors.forename: Maggie R
authors.initials: MR
authors.lastname: Jinks
authors.affiliation: Animal Eye Care Associates, Cary, NC, USA.
authors.forename: Robert V
authors.initials: RV
authors.lastname: English
authors.affiliation: College of Veterinary Medicine, NCSU-CVM, Clinical Sciences, Raleigh, NC, USA.
authors.forename: Brian C
authors.initials: BC
authors.lastname: Gilger
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology / Q000821:virology; D002415:Cats; D005260:Female; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000662:veterinary; D009657:North Carolina / Q000453:epidemiology; D014605:Uveitis / Q000209:etiology / Q000382:microbiology / Q000662:veterinary* / Q000821:virology
keywords: causes; endogenous uveitis; feline uveitis; prevalence