title: Effect of preemptive analgesia with parecoxib sodium in patients undergoing radical resection of lung cancer.
abstract: OBJECTIVE
  To discuss the effect of preemptive analgesia with parecoxib sodium in patients undergoing radical resection of lung cancer.
  
  
  METHODS
  115 cases of lung cancer patients with American society of anesthesiologists class (ASA) grade I~II who received selective operation were randomly divided into the research group and the control group. The research group patients were given preoperative parecoxib sodium 40 mg plus postoperative normal saline 2 ml, while the control group patients were treated with preoperative normal saline 2 ml plus postoperative parecoxib sodium 40 mg. The pain condition at postoperative 1, 2, 4, 8, 12, 24 and 48 h were evaluated by visual analogue scale (VAS), and emergence agitation was tested by agitation score.
  
  
  RESULTS
  Finally there were 56 cases and 57 cases can be used for evaluation in the research group and control group. The VAS scores after 1, 2, 4, 8, 12, 24 and 48 h in the research group and control group were [2.23±0.45, 2.35±0.48, 2.51±0.51, 2.41±0.45, 2.28±0.42, 2.16±0.39, 2.11±0.40] and [3.80±0.62, 4.01±0.64, 4.31±0.67, 4.10±0.64, 3.65±0.70, 3.12±0.66, 2.46±0.53], respectively. The research group were obviously lower than the control group, the difference were statistically significant (P<0.05). The rate of agitation was 24.44% (11/56) in the research group, significantly lower than the control group of 59.65% (34/57) (P<0.05).
  
  
  CONCLUSIONS
  Preemptive analgesia with parecoxib sodium can obviously relieve acute pain using in patients undergoing radical resection of lung cancer, and is helpful to reduce the incidence of emergence agitation.
authors.affiliation: The Second Hospital of Shandong University Jinan 250033, Shandong Province, P. R China ; Department of Anesthesiology, Linyi People's Hospital Linyi 276003, Shandong Province, P. R China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Anesthesiology, Linyi People's Hospital Linyi 276003, Shandong Province, P. R China.
authors.forename: Zhongkai
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Linyi People's Hospital Linyi 276003, Shandong Province, P. R China.
authors.forename: Kunpeng
authors.initials: K
authors.lastname: Xia
authors.affiliation: Department of Anesthesiology, Linyi People's Hospital Linyi 276003, Shandong Province, P. R China.
authors.forename: Changzhong
authors.initials: C
authors.lastname: Shao
authors.affiliation: Department of Anesthesiology, Linyi People's Hospital Linyi 276003, Shandong Province, P. R China.
authors.forename: Shengdong
authors.initials: S
authors.lastname: Guo
authors.affiliation: Department of Anesthesiology, Linyi People's Hospital Linyi 276003, Shandong Province, P. R China.
authors.forename: Shenggang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, The Second Hospital of Shandong University Jinan 250033, Shandong Province, China.
authors.forename: Kezhong
authors.initials: K
authors.lastname: Li
keywords: Parecoxib sodium; preemptive analgesia; radical resection of lung cancer; visual analogue scale