title: Risk Factors of Disease Progression After Cataract Surgery in Chronic Angle-closure Glaucoma Patients.
abstract: OBJECTIVE
  To evaluate clinical risk factors of disease progression after cataract surgery using phacoemulsification with posterior chamber intraocular lens implantation, in eyes with chronic angle-closure glaucoma (CACG) and coexisting cataract.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  The data of 56 eyes of 45 CACG patients who had undergone uncomplicated phacoemulsification with posterior chamber intraocular lens implantation were retrospectively analyzed. Disease progression was defined as glaucomatous optic nerve change or visual field (VF) deterioration according to the European Glaucoma Society guideline. Correlations between VF progression and various preoperative and postoperative factors were determined by χ and independent t tests. Linear regression analysis [(odds ratio (OR)] was used to determine predictive risk factors for disease progression using univariate and multivariate analyses.
  
  
  RESULTS
  The mean postoperative follow-up period was 45.13 ± 17.54 (24 to 84) months. Fourteen eyes (25%) with cataracts diagnosed with CACG progressed after phacoemulsification, but the remaining 42 eyes (75%) did not. According to univariate analysis, disease progression was significantly associated with older age, more number of preoperative/postoperative antiglaucoma drugs, higher scores of preoperative pattern standard deviation, and lower scores of preoperative and postoperative visual field index (VFI) (P<0.05). Using multivariate analysis, a lower score of preoperative VFI (OR: 0.86, P=0.044) and lower postoperative intraocular pressure (IOP) reduction, which was not sustained below 20% less than the preoperative mean IOP, were significantly correlated with disease progression after cataract surgery (OR: 8.44, P=0.048).
  
  
  CONCLUSIONS
  CACG patients with low preoperative VFI and high postoperative IOP are at risk for disease progression even after uncomplicated cataract surgery.
authors.affiliation: *Department of Ophthalmology, Maryknoll Hospital, Busan †Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine §Nune Eye Hospital, Seoul ‡Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors.forename: Chang Kyu
authors.initials: CK
authors.lastname: Lee
authors.forename: Na Eun
authors.initials: NE
authors.lastname: Lee
authors.forename: Samin
authors.initials: S
authors.lastname: Hong
authors.forename: Eunmin
authors.initials: E
authors.lastname: Kang
authors.forename: Seung Soo
authors.initials: SS
authors.lastname: Rho
authors.forename: Gong Je
authors.initials: GJ
authors.lastname: Seong
authors.forename: Young Jae
authors.initials: YJ
authors.lastname: Hong
authors.forename: Chan Yun
authors.initials: CY
authors.lastname: Kim
mesh_terms: D000368:Aged; D002386:Cataract / Q000150:complications; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015812:Glaucoma, Angle-Closure / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000175:diagnosis; D018918:Phacoemulsification; D012189:Retrospective Studies; D012307:Risk Factors; D014786:Vision Disorders / Q000175:diagnosis; D014794:Visual Fields