title: DPG-plus syndrome: new report of a rare entity.
abstract: Pituitary gland duplication is a particularly rare finding. Different theories have been proposed to explain its pathogenesis, however, this phenomenon is not yet totally understood. Recently, duplication of the pituitary gland (DPG)-plus syndrome has been described, associating DPG with other blastogenic defects. We present the clinical and imaging findings of a newborn girl with DPG, associated with multiple other midline anomalies, including a nasopharyngeal teratoma, palate cleft deformity, bifid nasal bridge, tongue and uvula, hypoplasia of the basis pontis and corpus callosum, duplication of the basilar artery and hypothalamic hamartoma. We describe our patient's multidisciplinary team approach and emphasise the importance of reporting upcoming cases, in order to give more insight into the understanding of this complex entity.
authors.affiliation: Department of Pediatrics, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
authors.forename: Laura
authors.initials: L
authors.lastname: Azurara
authors.affiliation: Department of Pediatrics, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
authors.forename: Mónica
authors.initials: M
authors.lastname: Marçal
authors.affiliation: Department of Pediatrics, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
authors.forename: Filipa
authors.initials: F
authors.lastname: Vieira
authors.affiliation: Department of Pediatrics, Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
authors.forename: Madalena Lopo
authors.initials: ML
authors.lastname: Tuna
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging; D002972:Cleft Palate / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D010902:Pituitary Gland / Q000002:abnormalities* / Q000601:surgery; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D014059:Tongue / Q000002:abnormalities* / Q000601:surgery; D016896:Treatment Outcome