title: Core Length: An Alternative Method for Increasing Cancer Detection Rate in Patients with Prostate Cancer.
abstract: OBJECTIVE
  We determine whether the lengths of benign and malignant cores affect cancer detection rates in patients with prostate cancer (PCa).
  
  
  METHODS
  We evaluated retrospectively 512 patients in our clinic who had undergone 12 core transrectal ultrasound (TRUS)-guided prostate biopsies. The cores were divided into two groups: one with cancer (group 1) and one without cancer (group 2). We also classified Gleason scores as poorly differentiated (scores of 7-10) and moderately differentiated (scores of 5-6); these scores were compared with each other in terms of the core length. The core lengths of the groups were compared using a Student's t-test. A P value of less than .05 was considered to be statistically significant.
  
  
  RESULTS
  Of the 512 patients, 76 (15%) had PCa. In total, we evaluated 912 cores of prostate biopsy samples from the 76 patients. Since 92 cores included insufficient tissue and rectal mucosa, we were not able to evaluate them. The remaining 820 cores were divided into two groups. Cancer was detected in 302 cores; 518 cores were benign in nature. The average core length in group 1 was 11.9 ± 4.4 mm, and the average core length in group 2 was 11.1 ± 5.1 mm (P = .015). The core lengths of poorly differentiated and moderately differentiated cancers were similar: 12.3 ± 4.2 mm and 11.7 ± 4.5 mm, respectively (P = .25).
  
  
  CONCLUSIONS
  Increasing cancer detection rates in cores may be related to core length in TRUS-guided prostate biopsies in PCa patients.
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey. drdoluoglu@yahoo.com.tr.
authors.forename: Omer Gokhan
authors.initials: OG
authors.lastname: Doluoglu
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Cem Nedim
authors.initials: CN
authors.lastname: Yuceturk
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Eroglu
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Berat Cem
authors.initials: BC
authors.lastname: Ozgur
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Demirbas
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Karakan
authors.affiliation: Department of Biostatistics and Medical Informatics, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Selen
authors.initials: S
authors.lastname: Bozkurt
authors.affiliation: Department of Urology, Clinic of Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Berkan
authors.initials: B
authors.lastname: Resorlu
mesh_terms: D000368:Aged; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies