title: Comparison of hair thyroid hormones between first-episode and recurrent patients with depression in female Chinese.
abstract: OBJECTIVE
  The aim of this study was to compare hair thyroid hormone (TH) levels among first-episode patients with major depressive disorder (F-MDD), recurrent patients with major depressive disorder (R-MDD) and healthy controls (HC).
  
  
  METHODS
  The Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to evaluate the clinical symptoms of patients. Electrochemiluminescence immunoassay was used to measure the hair TH levels. We compared the differences in hair TH levels among F-MDD patients, R-MDD patients, and HC.
  
  
  RESULTS
  Before the disease episode, hair T3 levels differed significantly between F-MDD patients and HC. In the disease episode, hair T3 levels differed significantly between F-MDD or R-MDD patients and HC; and hair T4 levels differed significantly between R-MDD patients and HC. Hair T3 levels significantly negative correlated with HAMD scores in F-MDD patients.
  
  
  CONCLUSIONS
  Our findings suggested that disease duration of recurring episodes of depression may influence hair TH levels.
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Psychiatry, Binzhou Medical University Hospital, Binzhou, China.
authors.forename: Guizhi
authors.initials: G
authors.lastname: Sun
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.|National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Jinxue
authors.initials: J
authors.lastname: Wei
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Huang
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.|National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Liansheng
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.|National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Center of Psychosomatic Medicine, Sichuan Provincial People's Hospital, Chengdu, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.|National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Li
authors.initials: L
authors.lastname: Tao
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China. maxiaohong@scu.edu.cn.|National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. maxiaohong@scu.edu.cn.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China; D003865:Major Depressive Disorder / Q000378:metabolism*; D005260:Female; D006197:Hair / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D013963:Thyroid Hormones / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism; D055815:Young Adult
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D013974:Thyroxine
keywords: depression; first-episode; hair; recurrent; thyroid hormone