title: MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is considered to be the most lethal and aggressive malignancy with high mortality and poor prognosis. Their responses to current multimodal therapeutic regimens are limited. It is urgently needed to identify the molecular mechanism underlying pancreatic oncogenesis. Twelve core signaling cascades have been established critical in PDAC tumorigenesis by governing a wide variety of cellular processes. MicroRNAs (miRNAs) are aberrantly expressed in different types of tumors and play pivotal roles as post-transcriptional regulators of gene expression. Here, we will describe how miRNAs regulate different signaling pathways that contribute to pancreatic oncogenesis and progression.
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Longhao
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston 77030, USA.
authors.forename: Corrine Ying Xuan
authors.initials: CYX
authors.lastname: Chua
authors.affiliation: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Tian
authors.affiliation: Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston 77030, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Chiao
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston 77030, USA; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address: wzhang@mdanderson.org.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: D035683:MicroRNAs
keywords: MicroRNA; Pancreatic ductal adenocarcinoma; Signaling pathway; Tumorigenesis