title: Tubulointerstitial Nephritis Caused by Peritubular Capillaritis Accompanied by Cryoglobulinemia.
abstract: A 73-year-old man with fever, renal insufficiency, and purpura was referred to our hospital to be evaluated for renal insufficiency. Renal biopsy revealed acute and chronic tubulointerstitial nephritis with no laboratory findings of sarcoidosis or connective tissue disease. Low C4 levels and elevation of rheumatoid factors suggested cryoglobulinemia, which was confirmed with quantitative analysis. CD34 staining of kidney tissue revealed peritubular capillaritis. Antineutrophil cytoplasmic antibodies were negative. The etiology of peritubular capillaritis was not clear in our patient; however, it might be associated with cryoglobulinemia because we cannot find any other diseases that could have induced the peritubular capillaritis.
authors.affiliation: Division of Nephrology, First Department of Medicine, Hamamatsu University School of Medicine, Japan.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Iwakura
authors.forename: Akio
authors.initials: A
authors.lastname: Namikawa
authors.forename: Naoko
authors.initials: N
authors.lastname: Tsuji
authors.forename: Sayaka
authors.initials: S
authors.lastname: Ishigaki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Isobe
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ono
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Sakao
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tsuji
authors.forename: Naro
authors.initials: N
authors.lastname: Ohashi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kato
authors.forename: Mana
authors.initials: M
authors.lastname: Goto
authors.forename: Hideo
authors.initials: H
authors.lastname: Yasuda
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism*; D002196:Capillaries / Q000473:pathology; D003449:Cryoglobulinemia / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000209:etiology / Q000473:pathology*; D051437:Renal Insufficiency / Q000209:etiology / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D019268:Antibodies, Antineutrophil Cytoplasmic