title: Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation.
abstract: Macrophages are present in a large variety of locations, playing distinct functions that are determined by its developmental origin and by the nature of the activators of the microenvironment. Macrophage activation can be classified as pro-inflammatory (M1 polarization) or anti-inflammatory-pro-resolution-deactivation (M2), these profiles coexisting in the course of the immune response and playing a relevant functional role in the onset of inflammation (Figure 1). Several groups have analysed the metabolic aspects associated with macrophage activation to answer the question about what changes in the regulation of energy metabolism and biosynthesis of anabolic precursors accompany the different types of polarization and to what extent they are necessary for the expression of the activation phenotypes. The interest of these studies is to regulate macrophage function by altering their metabolic activity in a 'therapeutic way'.
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, (Centro Mixto CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Monforte de Lemos 3-5, Instituto de Salud Carlos III, 28029 Madrid, Spain lbosca@iib.uam.es.
authors.forename: Lisardo
authors.initials: L
authors.lastname: Boscá
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, (Centro Mixto CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: González-Ramos
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, (Centro Mixto CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Prieto
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, (Centro Mixto CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Fernández-Velasco
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, (Centro Mixto CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Mojena
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, (Centro Mixto CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Monforte de Lemos 3-5, Instituto de Salud Carlos III, 28029 Madrid, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Martín-Sanz
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, (Centro Mixto CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Alemany
mesh_terms: D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D010084:Oxidation-Reduction; D010766:Phosphorylation
chemical_list: D005947:Glucose
keywords: glycolysis; inflammation; inhibitors; isoenzyme; macrophage; metabolism