title: The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis.
abstract: We investigated the effect of Jiangya Tongluo (JYTL) formula on renal function in rats with hypertensive nephrosclerosis. A total of 21 spontaneously hypertensive rats (SHRs) were randomized into 3 groups: valsartan (10 mg/kg/d valsartan), JYTL (14.2 g/kg/d JYTL), and a model group (5 mL/kg/d distilled water); Wistar Kyoto rats comprised the control group (n = 7, 5 mL/kg/d distilled water). Treatments were administered by gavage every day for 8 weeks. Blood pressure, 24-h urine protein, pathological changes in the kidney, serum creatinine, and blood urea nitrogen (BUN) levels were estimated. The contents of adrenomedullin (ADM) and angiotensin II (Ang II) in both the kidney and plasma were evaluated. JYTL lowered BP, 24-h urine protein, serum creatinine, and BUN. ADM content in kidneys increased and negatively correlated with BP, while Ang II decreased and negatively correlated with ADM, but there was no statistically significant difference of plasma ADM between the model and the treatment groups. Possibly, activated intrarenal renin-angiotensin system (RAS) plays an important role in hypertensive nephrosclerosis and the protective function of ADM via local paracrine. JYTL may upregulate endogenous ADM level in the kidneys and antagonize Ang II during vascular injury by dilating renal blood vessels.
authors.affiliation: College of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Han
authors.affiliation: Molecular Research in Traditional Chinese Medicine Group, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Vienna General Hospital, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Nephrology, Dongfang Hospital, The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100078, China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Qin
authors.affiliation: College of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Li
authors.affiliation: College of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Gao
authors.affiliation: Department of Nephrology, Dongfang Hospital, The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100078, China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, Dongfang Hospital, The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100078, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.affiliation: College of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Lin-Mei
authors.initials: LM
authors.lastname: Song
authors.affiliation: Department of Nephrology, Dongfang Hospital, The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100078, China.
authors.forename: Yan-Ni
authors.initials: YN
authors.lastname: Luo
authors.affiliation: Department of Nephrology, Dongfang Hospital, The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100078, China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Chi