title: New Phloroglucinol Derivatives from the Fruit Tree Syzygium jambos and Their Cytotoxic and Antioxidant Activities.
abstract: Seven new phloroglucinol derivatives (1-7) were isolated from the fruit tree Syzygium jambos together with four known triterpenoids (8-11) and two known flavones (12 and 13). According to the spectroscopic analyses (infrared, electrospray ionization mass spectrometry (ESIMS), high-resolution ESIMS, 1D and 2D nuclear magnetic resonance), the structures of compounds 1-7 were elucidated as jambone A (1), jambone B (2), jambone C (3), jambone D (4), jambone E (5), jambone F (6), and jambone G (7). All the isolates were determined for their cytotoxic activities on melanoma cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and compounds 10 and 11 showed potent activities. Moreover, compounds 1, 2, 4-7, 12, and 13 exhibited weak antioxidant activities under ferric-reducing antioxidant power and 2,2-diphenyl-1-picryhydrazyl radical-scavenging assays.
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Li
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine , Guangzhou 510006, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.forename: Neng-Hua
authors.initials: NH
authors.lastname: Chen
authors.forename: Zhong-Nan
authors.initials: ZN
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Rui-Xia
authors.initials: RX
authors.lastname: Qiu
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
mesh_terms: D005638:Fruit / Q000737:chemistry; D015394:Molecular Structure; D010696:Phloroglucinol / Q000737:chemistry* / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity; D027842:Syzygium / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D010696:Phloroglucinol
keywords: Syzygium jambos; antioxidant activity; cytotoxic activity; phloroglucinol derivatives; structure identification