title: [Obesity and characteristics of endometrial cancer: are there any changes over several decades?].
abstract: It is shown that endometrial cancer features (including expression of the PTEN and HER-2/neu proteins) are connected dissimilarly with body mass index and with the belonging of the patients to the groups with standard, SO and metabolically healthy obesity, MHO. In the course of the last half-century an increases are discovered in the height and weight of the females with endometrial cancer that moves in the opposite direction with a reduction of the share of MHO cases among obese patients. This conclusion should be taken into account when one considers the means for contemporary prevention of both obesity and cancer of uterine body.
authors.forename: L M
authors.initials: LM
authors.lastname: Berstein
authors.forename: I V
authors.initials: IV
authors.lastname: Berlev
authors.forename: D A
authors.initials: DA
authors.lastname: Vasiliev
authors.forename: A N
authors.initials: AN
authors.lastname: Baltrukova
authors.forename: T E
authors.initials: TE
authors.lastname: Poroshina
authors.forename: I M
authors.initials: IM
authors.lastname: Kovalenko
authors.forename: E A
authors.initials: EA
authors.lastname: Turkevich
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D015992:Body Mass Index; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009765:Obesity / Q000378:metabolism / Q000473:pathology*; D051059:PTEN Phosphohydrolase / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D051059:PTEN Phosphohydrolase; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human; C494929:PTEN protein, human