title: Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants.
abstract: A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo.
authors.affiliation: Department of Chemistry, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
authors.forename: Victoria J A
authors.initials: VJ
authors.lastname: Jameson
authors.affiliation: MRC Clinical Sciences Centre, Imperial College, London, W12 0NN, UK ; MRC Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK.
authors.forename: Helena M
authors.initials: HM
authors.lastname: Cochemé
authors.affiliation: MRC Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK.
authors.forename: Angela
authors.initials: A
authors.lastname: Logan
authors.affiliation: Department of Chemistry, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
authors.forename: Lyall R
authors.initials: LR
authors.lastname: Hanton
authors.affiliation: Department of Chemistry, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
authors.forename: Robin A J
authors.initials: RA
authors.lastname: Smith
authors.affiliation: MRC Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
keywords: Lipid peroxidation; MitoE; Mitochondria; Mitochondria-targeted antioxidant; Vitamin E