title: Management of malignant pleural mesothelioma: a French multicenter retrospective study (GFPC 0802 study).
abstract: BACKGROUND
  Malignant pleural mesothelioma (MPM) is a rare disease with poor prognosis in spite of significant improvement in survival, due to new chemotherapy regimens. We describe here patients' profiles and management in daily practice in France.
  
  
  METHODS
  Observational retrospective study. Data were collected from medical files. All patients with histologically proven MPM diagnosed from January 2005 to December 2008 were included in the participating sites.
  
  
  RESULTS
  Four hundred and six patients were included in 37 sites: mean age 68.9 ± 9.8 years, male predominance (sex ratio 3.27), latency of the disease 45.7 years, epithelioïd type 83 %. Diagnosis was made using thoracoscopy in 80.8 % of patients. Radical surgery was performed in 6.2 % of cases. Chemotherapy was administered to 74.6 % of patients. First line regimens consisted mainly of platinum + pemetrexed (91 %) or pemetrexed alone (7 %). Objective response rate was 17.2 % and another 41.6 % of patients experienced disease stabilization. Half of these patients underwent second line chemotherapy (platinium + pemetrexed 31.6 %, pemetrexed alone 24.6 %), resulting in a 6 % response rate. Third-line chemotherapy (56 patients) yielded disease control in 5.4 % of cases.
  
  
  CONCLUSIONS
  The management of MPM in France is usually in accordance with guidelines. Response rates are somewhat lower than those described in clinical trials.
authors.affiliation: Service de Pneumologie, CH Argenteuil, Argenteuil, France. christine.raynaud@ch-argenteuil.fr.
authors.forename: C
authors.initials: C
authors.lastname: Raynaud
authors.affiliation: Service d'oncologie thoracique, APHM, Marseille, Services de Pneumologie, Marseille, France. laurent.greillier@ap-hm.fr.
authors.forename: L
authors.initials: L
authors.lastname: Greillier
authors.affiliation: CHU Toulouse, Toulouse, France. mazieres.j@chu-toulouse.fr.
authors.forename: J
authors.initials: J
authors.lastname: Mazieres
authors.affiliation: Service de pneumologie, CHI Créteil, 40 avenue de verdun, 94010, Créteil, France. isabelle.monnet@chicreteil.fr.
authors.forename: I
authors.initials: I
authors.lastname: Monnet
authors.affiliation: CHU Lyon, Lyon, France. benedicte.mastroianni@hcl.fr.
authors.forename: B
authors.initials: B
authors.lastname: Mastroianni
authors.affiliation: CHU Brest, Brest, France. gilles.robinet@chu-brest.fr.
authors.forename: G
authors.initials: G
authors.lastname: Robinet
authors.affiliation: CH Cergy Pontoise, Cergy Pontoise, France. gislaine.fraboulet@ch-pontoise.fr.
authors.forename: G
authors.initials: G
authors.lastname: Fraboulet
authors.affiliation: CH d'Orléans, Orléans, France. adrien.dixmier@chu-orleans.fr.
authors.forename: A
authors.initials: A
authors.lastname: Dixmier
authors.affiliation: HIA Toulon, Toulon, France. hlberard@orange.fr.
authors.forename: H
authors.initials: H
authors.lastname: Berard
authors.affiliation: CH Lorient, Lorient, France. regine.lamy@orange.fr.
authors.forename: R
authors.initials: R
authors.lastname: Lamy
authors.affiliation: CH Aix en Provence, Aix en Provence, France. jletreut@ch-aix.fr.
authors.forename: J
authors.initials: J
authors.lastname: Letreut
authors.affiliation: CHU Rennes, Rennes, France. herve.lena@chu-rennes.fr.
authors.forename: H
authors.initials: H
authors.lastname: Lena
authors.affiliation: CH Longjumeau, Longjumeau, France. gerard.oliviero@ch-longjumeau.fr.
authors.forename: G
authors.initials: G
authors.lastname: Oliviero
authors.affiliation: CHU Rouen, Rouen, France. suzanna.botta@chu-rouen.fr.
authors.forename: S
authors.initials: S
authors.lastname: Botta
authors.affiliation: CHU Limoges, Limoges, France. alain.vergnenegre@unilim.fr.
authors.forename: A
authors.initials: A
authors.lastname: Vergnenegre
authors.affiliation: IGR, Villejuif, France. isabelle.borget@igr.fr.
authors.forename: I
authors.initials: I
authors.lastname: Borget
authors.affiliation: Service de pneumologie, CHI Créteil, 40 avenue de verdun, 94010, Créteil, France. christos.chouaid@chicreteil.fr.
authors.forename: C
authors.initials: C
authors.lastname: Chouaid
mesh_terms: D000368:Aged; D019468:Disease Management; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors