title: Voltammetric Aptasensor Based on Magnetic Beads Assay for Detection of Human Activated Protein C.
abstract: Aptamers are defined as new generation of nucleic acids, which has recently presented promising specifications over to antibodies. An increasing number of electrochemical studies related to aptamer-based sensors, so-called aptasensors have been introduced in the literature. Herein, the interaction between human activated protein C (APC) and its cognate DNA aptamer (DNA APT) was performed at the surface of magnetic beads (MBs), followed by voltammetric detection using disposable graphite electrodes (PGEs).
authors.affiliation: Faculty of Pharmacy, Analytical Chemistry Department, Ege University, 35100, Bornov, Izmir, Turkey. arzum.erdem@ege.edu.tr.
authors.forename: Arzum
authors.initials: A
authors.lastname: Erdem
authors.affiliation: Faculty of Pharmacy, Analytical Chemistry Department, Ege University, 35100, Bornov, Izmir, Turkey.
authors.forename: Gulsah
authors.initials: G
authors.lastname: Congur
authors.affiliation: Faculty of Pharmacy, Analytical Chemistry Department, Ege University, 35100, Bornov, Izmir, Turkey.
authors.forename: Ece
authors.initials: E
authors.lastname: Eksin
mesh_terms: D052157:Aptamers, Nucleotide / Q000378:metabolism; D015374:Biosensing Techniques; D055664:Electrochemical Techniques / Q000379:methods; D006801:Humans; D018189:Immunomagnetic Separation / Q000379:methods; D011486:Protein C / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide; D011486:Protein C
keywords: Aptasensors; Electrochemistry; Human activated protein C; Magnetic beads; Voltammetry