title: Effect of the surface free energy of materials on the lamination tendency of bilayer tablets.
abstract: Dosage forms with fixed dose combinations of drugs is a frequent and advantageous mode of administration, but their production involves a number of technological problems. Numerous interactions in a homogeneous vehicle may be avoided through the use of layered tablets. The mechanical properties of these dosage forms depend on numerous process parameters and material characteristics. The aim of the present study was a detailed investigation of the relationships between the surface characteristics and deformation properties of tableting materials and the tendency of bilayer tablets to undergo lamination. Bilayer tablets were compressed from unlubricated materials with different plastic-elastic properties and surface free energies according to a mixed 2 and 3-level half-replicated factorial design. The results revealed that the surface characteristics play the main role in the lamination of layered tablets and the effect of the plastic-elastic behavior cannot be interpreted without a knowledge of these properties.
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, Szeged H-6720, Hungary.
authors.forename: Kitti
authors.initials: K
authors.lastname: Papós
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, Szeged H-6720, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Kása
authors.affiliation: Department of Pharmaceutical Technology, University of Ljubljana, Aškerčeva cesta 7, Ljubljana 1000, Slovenia.
authors.forename: Ilija
authors.initials: I
authors.lastname: Ilič
authors.affiliation: Krka d.d., Šmarješka cesta 6, Novo mesto 8501, Slovenia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Blatnik-Urek
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, Szeged H-6720, Hungary.
authors.forename: Géza
authors.initials: G
authors.lastname: Regdon
authors.affiliation: Department of Pharmaceutical Technology, University of Ljubljana, Aškerčeva cesta 7, Ljubljana 1000, Slovenia.
authors.forename: Stane
authors.initials: S
authors.lastname: Srčič
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, Szeged H-6720, Hungary.
authors.forename: Klára
authors.initials: K
authors.lastname: Pintye-Hódi
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, Szeged H-6720, Hungary. Electronic address: t.sovany@pharm.u-szeged.hu.
authors.forename: Tamás
authors.initials: T
authors.lastname: Sovány
mesh_terms: D004548:Elasticity; D013499:Surface Properties; D013607:Tablets / Q000138:chemical synthesis*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013718:Tensile Strength
chemical_list: D013607:Tablets
keywords: Bilayer tablets; Lamination tendency; Plasto-elastic behaviour; Surface free energy