title: Serum levels of TGF-β1 in patients of diabetic peripheral neuropathy and its correlation with nerve conduction velocity in type 2 diabetes mellitus.
abstract: OBJECTIVE
  To correlate serum levels of TGF-β1 with motor and sensory nerve conduction velocities in patients of type 2 diabetes mellitus
  
  
  METHODS
  The study was conducted in diagnosed type 2 diabetes mellitus patients which were divided in patients with clinically detectable peripheral neuropathy of shorter duration (n=37) and longer duration (n=27). They were compared with patients without clinical neuropathy (n=22). Clinical diagnosis was based on neuropathy symptom score (NSS) and Neuropathy disability score (NDS) for signs. Blood samples were collected for baseline investigations and estimation of serum TGF-β1. Nerve conduction velocity was measured in both upper and lower limbs. Median, Ulnar, Common Peroneal and Posterior Tibial nerves were selected for motor nerve conduction study and Median and Sural nerves were selected for sensory nerve conduction study
  
  
  RESULTS
  In patients of type 2 diabetes mellitus with clinically detectable and serum TGF-β1 showed positive correlation with nerve conduction velocities
  
  
  CONCLUSIONS
  High level of TGF-β1 in serum of T2DM patients with neuropathy show possible contribution in development of neuropathy. Due to its independent association this cytokine might be used as biomarker for diabetic peripheral neuropathy.
authors.affiliation: Department of Physiology, Teerthankar Mahaveer Medical College & Research Centre, Teerthankar Mahaveer University, Moradabad, U.P., India.
authors.forename: Gauhar
authors.initials: G
authors.lastname: Hussain
authors.affiliation: Department of Physiology, J.N. Medical College & Hospital, Aligarh Muslim University, Aligarh, U.P., India.
authors.forename: S Aijaz Abbas
authors.initials: SA
authors.lastname: Rizvi
authors.affiliation: Department of Physiology, J.N. Medical College & Hospital, Aligarh Muslim University, Aligarh, U.P., India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Singhal
authors.affiliation: Rajiv Gandhi Centre for Diabetes and Endocrinology, J.N. Medical College & Hospital, Aligarh Muslim University, Aligarh 202002, U.P., India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zubair
authors.affiliation: Rajiv Gandhi Centre for Diabetes and Endocrinology, J.N. Medical College & Hospital, Aligarh Muslim University, Aligarh 202002, U.P., India. Electronic address: jamalahmad11@rediffmail.com.
authors.forename: Jamal
authors.initials: J
authors.lastname: Ahmad
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D013497:Sural Nerve / Q000502:physiology; D013979:Tibial Nerve / Q000502:physiology; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1
keywords: Diabetic peripheral neuropathy; Nerve conduction velocity; TGF-β1; Type 2 diabetes mellitus