title: Maternal anti-HLA class I antibodies are associated with reduced birth weight in thrombocytopenic neonates.
abstract: In this comparative cross-sectional study, possible associations between maternal anti-HLA class I antibodies and birth weight in neonatal thrombocytopenia are explored. Although commonly detected in pregnancies and generally regarded as harmless, it has been suggested that such antibodies might be associated with fetal and neonatal alloimmune thrombocytopenia (FNAIT). As a link between FNAIT due to human platelet antigen 1a-specific antibodies and reduced birth weight in boys has previously been demonstrated, we wanted to explore whether maternal anti-HLA class I antibodies might also affect birth weight. To examine this, suspected cases of FNAIT referred to the Norwegian National Unit for Platelet Immunology during the period 1998-2009 were identified. Pregnancies where the only finding was maternal anti-HLA class I antibodies were included. An unselected group of pregnant women participating in a prospective study investigating maternal-fetal hemodynamics at the University Hospital North Norway during the years 2006-2010 served as controls. Twenty-nine percent of controls had anti-HLA class I antibodies. The thrombocytopenic neonates had a significantly lower adjusted birth weight (linear regression, P=0.036) and significantly higher odds of being small for gestational age (OR=6.72, P<0.001) compared with controls. Increasing anti-HLA class I antibody levels in the mother were significantly associated with lower birth weight and placental weight among thrombocytopenic neonates, but not among controls. These results indicate that maternal anti-HLA class I antibodies in thrombocytopenic neonates are associated with reduced fetal growth. Further studies are needed to test if placental function is affected.
authors.affiliation: Immunology Research Group, UiT, The Arctic University of Norway, Tromsø, Norway.
authors.forename: J
authors.initials: J
authors.lastname: Dahl
authors.affiliation: Immunology Research Group, UiT, The Arctic University of Norway, Tromsø, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Husebekk
authors.affiliation: Women's Health and Perinatology Research Group, UiT, The Arctic University of Norway, Tromsø, Norway; Department of Obstetrics & Gynecology, University Hospital of North Norway, Tromsø, Norway.
authors.forename: G
authors.initials: G
authors.lastname: Acharya
authors.affiliation: Women's Health and Perinatology Research Group, UiT, The Arctic University of Norway, Tromsø, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Flo
authors.affiliation: Immunology Research Group, UiT, The Arctic University of Norway, Tromsø, Norway.
authors.forename: T B
authors.initials: TB
authors.lastname: Stuge
authors.affiliation: Norwegian National Unit for Platelet Immunology, Tromsø, Norway.
authors.forename: B
authors.initials: B
authors.lastname: Skogen
authors.affiliation: Department of Community Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.
authors.forename: B
authors.initials: B
authors.lastname: Straume
authors.affiliation: Immunology Research Group, UiT, The Arctic University of Norway, Tromsø, Norway; Department of Obstetrics & Gynecology, University Hospital of North Norway, Tromsø, Norway. Electronic address: heidi.tiller@unn.no.
authors.forename: H
authors.initials: H
authors.lastname: Tiller
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000097:blood / Q000276:immunology*; D006801:Humans; D007230:Infant, Low Birth Weight / Q000097:blood / Q000276:immunology*; D007518:Isoantibodies / Q000097:blood / Q000276:immunology*; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D010920:Placenta / Q000276:immunology* / Q000378:metabolism; D011247:Pregnancy; D012189:Retrospective Studies; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000097:blood / Q000276:immunology*
chemical_list: D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies
keywords: Alloimmunization; Antibodies; Birth weight; Neonatal thrombocytopenia; Placenta