title: Effect of fluidics on corneal endothelial cell density, central corneal thickness, and central macular thickness after phacoemulsification with torsional ultrasound.
abstract: OBJECTIVE
  To study the relative effects of high and low fluidic parameters on endothelial cell density (ECD), central corneal thickness (CCT), and central macular thickness (CMT) after phacoemulsification with torsional ultrasound.
  
  
  METHODS
  Prospective, randomized clinical trial based on a tertiary eye hospital.
  
  
  METHODS
  The study included 65 patients in each group. Patients were randomized to either the high or the low flow group using a computerized random number table. The study was patient and examiner masked. All patients underwent phacoemulsification with torsional ultrasound. Visual acuity, ECD, CCT, and CMT were measured for all patients preoperatively at 2 weeks and 6 weeks postoperatively.
  
  
  METHODS
  The Shapiro-Wilks test was used to assess the normality of the data. Mann-Whitney U-test with the P value set at 0.05 was used to compare the two groups.
  
  
  RESULTS
  Cumulative dissipated energy was significantly higher in the low flow group (16.44 ± 9.07 vs. 11.74 ± 6.68; P = 0.002). No statistically significant difference was noted between the two groups in the ECD, CCT, CMT, or corrected distance visual acuity at the end of 6 weeks.
  
  
  CONCLUSIONS
  No significant difference was noted in the postoperative outcome between high and low flow groups. Parameters can be modified to suit the surgeon's preference, as both high and low flow parameters were found to have comparable postoperative outcomes.
authors.forename: Sudeep
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Cataract and Refractive Surgery, Narayana Nethralaya Super Specialty Eye Hospital, Rajajinagar, Bengaluru; Lopamudra Medical Centre, Athur, Kodagu, Karnataka, India.
authors.forename: Soumya Ganesh
authors.initials: SG
authors.lastname: Nanaiah
authors.forename: Mathew K
authors.initials: MK
authors.lastname: Kummelil
authors.forename: Somshekar
authors.initials: S
authors.lastname: Nagappa
authors.forename: Rohit
authors.initials: R
authors.lastname: Shetty
authors.forename: Bhujang K
authors.initials: BK
authors.lastname: Shetty
mesh_terms: D002386:Cataract / Q000628:therapy*; D002452:Cell Count; D002809:Chondroitin Sulfates / Q000008:administration & dosage*; D063171:Corneal Pachymetry / Q000379:methods*; D004338:Drug Combinations; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007498:Iris / Q000000981:diagnostic imaging; D008266:Macula Lutea / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods*; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D007507:Therapeutic Irrigation / Q000379:methods; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*; D014792:Visual Acuity
chemical_list: D004338:Drug Combinations; C501944:chondroitin sulfate, sodium hyaluronate drug combination; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates