title: Role and Function of MicroRNAs in Extracellular Vesicles in Cardiovascular Biology.
abstract: Intercellular communication mediated by extracellular vesicles is crucial for preserving vascular integrity and in the development of cardiovascular disease. Extracellular vesicles consist of apoptotic bodies, microvesicles, and exosomes that can be found in almost every fluid compartment of the body like blood, saliva, and urine. In the recent years, a lot of reports came up suggesting that major cardiovascular and metabolic pathologies like atherogenesis, heart failure, or diabetes are highly influenced by transfer of microRNAs via extracellular vesicles leading to altered protein expression and phenotypes of recipient cells. The following review will summarize the fast developing field of intercellular signaling in cardiovascular biology by microRNA-containing extracellular vesicles.
authors.affiliation: Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, 53105 Bonn, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Pfeifer
authors.affiliation: Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, 53105 Bonn, Germany.
authors.forename: Nikos
authors.initials: N
authors.lastname: Werner
authors.affiliation: Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, 53105 Bonn, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Jansen
mesh_terms: D000818:Animals; D035843:Biomedical Research; D002318:Cardiovascular Diseases; D000067128:Extracellular Vesicles; D006801:Humans; D051379:Mice; D035683:MicroRNAs; D008955:Models, Cardiovascular
chemical_list: D035683:MicroRNAs