title: Pregnancy and Lupus Nephritis.
abstract: The management of lupus nephritis in pregnancy presents a diagnostic and therapeutic challenge for providers. Pregnancy creates a series of physiologic changes in the immune system and kidney that may result in an increased risk of disease flare and adverse maternal and fetal outcomes, such as preeclampsia, fetal loss, and preterm delivery. Conception should be delayed until disease is in remission to ensure the best pregnancy outcomes. Maternal disease activity and fetal well-being should be monitored closely by an interdisciplinary team, including obstetricians, rheumatologists, and nephrologists throughout pregnancy. Careful attention must be paid to the dosing and potential teratogenicity of medications.
authors.affiliation: Department of General Internal Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Andrea G
authors.initials: AG
authors.lastname: Kattah
authors.affiliation: Division of Nephrology and Hypertension, Department of General Internal Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Vesna D
authors.initials: VD
authors.lastname: Garovic
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000925:Anticoagulants / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D001241:Aspirin / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000276:immunology* / Q000502:physiology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D008181:Lupus Nephritis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy / Q000276:immunology* / Q000502:physiology; D011248:Pregnancy Complications / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D000925:Anticoagulants; D000959:Antihypertensive Agents; D005343:Fibrinolytic Agents; D007166:Immunosuppressive Agents; D001241:Aspirin
keywords: Pregnancy; anti-inflammatory agents/therapeutic use; lupus nephritis; preeclampsia; pregnancy complications; systemic lupus erythematosus