title: Laboratory assessments in the course of Parkinson's disease: a clinician's perspective.
abstract: Physicians, caregivers and patients themselves must be alert to the onset of and changes in motor and non-motor features during the course of Parkinson's disease (PD). Parallel laboratory routine assessments are necessary because of the evolving impairment of the general health status of the individual. A number of potential biomarkers for the diagnosis of PD are currently under investigation, with diagnosis early in the disease course a particular goal, even before the onset of motor symptoms. The aim of this guideline article is to provide user-friendly, clinical evidence-based recommendations for using laboratory pathological testing for the diagnosis and differential diagnosis of PD, for assessing its time course, and managing complications of long-term dopaminergic therapy and the disabling motor features that develop in the later stages of the disease.
authors.affiliation: Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13088, Berlin, Germany. th.mueller@alexius.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
authors.affiliation: Department of Neurology, Klinikum Hanau GmbH, Leimenstraße 20, 63450, Hanau, Germany.
authors.forename: Horst
authors.initials: H
authors.lastname: Baas
authors.affiliation: Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Kassubek
authors.affiliation: Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Füchsleinstrasse 15, 97080, Würzburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Riederer
authors.affiliation: Department of Neurology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Germany.
authors.forename: Peter Paul
authors.initials: PP
authors.lastname: Urban
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Schrader
authors.affiliation: Department of Neurology, Technische Universität of Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
authors.forename: Heinz
authors.initials: H
authors.lastname: Reichmann
authors.affiliation: Department of Neurology, Katholische Kliniken Ruhrhalbinsel GmbH, Heidbergweg 22-24, 45257, Essen, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Woitalla
authors.affiliation: Laboratory for Clinical Neurobiology and Therapeutic Drug Monitoring, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Würzburg, Füchsleinstrasse 15, 97080, Würzburg, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Gerlach
mesh_terms: D019411:Clinical Laboratory Techniques / Q000379:methods*; D003221:Confusion / Q000175:diagnosis / Q000209:etiology; D003704:Dementia / Q000175:diagnosis / Q000209:etiology; D003937:Diagnosis, Differential; D006801:Humans; D007980:Levodopa / Q000097:blood; D010300:Parkinson Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D011618:Psychotic Disorders / Q000175:diagnosis / Q000209:etiology; D014815:Vitamins / Q000378:metabolism
chemical_list: D014815:Vitamins; D007980:Levodopa
keywords: Diagnosis; Laboratory; Levodopa; Parkinson’s disease; Surveillance