title: Meroterpenoids from a Tropical Dysidea sp. Sponge.
abstract: Six new meroterpenoids (1-6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of Micronesia. On the basis of the results of combined spectroscopic analysis, compound 1 was determined to be the cyclic ether derivative of 7, whereas 2 and 3 were assigned as the corresponding sesquiterpene quinones containing taurine-derived substituents. Compounds 4-6 possess a novel tetracyclic skeleton formed by a direct linkage between the quinone and sesquiterpene moieties. The configurations of these new compounds were assigned on the basis of combined NOESY and ECD analysis. These compounds exhibited cytotoxic and antimicrobial activities and weak inhibition against Na(+)/K(+)-ATPase.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Chang-Kwon
authors.initials: CK
authors.lastname: Kim
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Jung-Kyun
authors.initials: JK
authors.lastname: Woo
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Seong-Hwan
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-921, Korea.
authors.forename: Eunji
authors.initials: E
authors.lastname: Cho
authors.affiliation: Marine Natural Products Laboratory, Korea Institute of Ocean Science & Technology , P.O. Box 29, Seoul 425-600, Korea.
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Marine Natural Products Laboratory, Korea Institute of Ocean Science & Technology , P.O. Box 29, Seoul 425-600, Korea.
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Biological Science, College of Life Science and Nano Technology, Hannam University , 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea.
authors.forename: Chung J
authors.initials: CJ
authors.lastname: Sim
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-921, Korea.
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D000818:Animals; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047088:Dysidea / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D008849:Micronesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D003603:Cytotoxins; D012717:Sesquiterpenes; D013729:Terpenes; C000605884:arenarol; D000254:Sodium-Potassium-Exchanging ATPase