title: Commentary on "A Framework for Quantifying the Influence of Adherence and Dose Individualization".
abstract: Drugs that provide long durations of action after a last-taken dose are said to be "forgiving," as they allow the patient a degree of latitude in the timing of sequential doses. New research, by Assawasuwannakit et al.,(1) based on exemplary methods, enriches the pharmacometric analysis of forgiveness, which for several decades had been a simply descriptive reminder that the beneficial actions of some drugs can continue for hours or days after the disappearance of detectable drug.
authors.affiliation: WestRock Healthcare, Visé, Belgium.|Department of Bioengineering & Therapeutic Sciences, UCSF, San Francisco, California, USA.
authors.forename: J
authors.initials: J
authors.lastname: Urquhart
authors.affiliation: WestRock Healthcare, Visé, Belgium.|University of Liège, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Vrijens
mesh_terms: D000069059:Atorvastatin / Q000008:administration & dosage*; D054796:Drug Dosage Calculations; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D055118:Medication Adherence; D015233:Models, Statistical; D009853:Omeprazole / Q000008:administration & dosage*; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D054328:Proton Pump Inhibitors; D000069059:Atorvastatin; D009853:Omeprazole