title: Synthesis, Radiolabeling, and Bioevaluation of Bis(Trifluoromethanesulfonyl) Imide.
abstract: Imidazolium salts have antitumor potential and toxicological effects on various microorganisms. The authors' aim is to synthesize a new imidazolium salt and to assess its pharmacokinetic and antitumor potentials by in vitro and in vivo studies. In this study, bis(trifluoromethanesulfonyl) imide (ITFSI) was synthesized and labeled with (131)I using the iodogen method. The efficiency of radiolabeling was determined with high yield (95.5% ± 3.7%). Pharmacokinetic properties of the compound were investigated in albino Wistar rats using radiolabeled compound. The radiolabeled compound ((131)I-ITFSI) has been stable during a period of 3 hours in human serum. The uptake of (131)I-ITFSI reached maximum in the spleen, liver, and blood at 60 minutes, large intestine and heart at 30 minutes, and ovary at 120 minutes. It is observed that intracellular uptake of the radiolabeled compound is higher in the CaCo-2 (colon adenocarcinoma tumor) cell line than HEK-293 (human epithelial kidney) cell line. In further study, antitumor potential of ITFSI on a colon adenocarcinoma tumor-bearing animal model may be investigated.
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .
authors.forename: Onur Alp
authors.initials: OA
authors.lastname: Ersöz
authors.affiliation: 2 Department of Biomedical Technology, Institute of Science, Ege University , Izmir, Turkey .
authors.forename: Hale Melis
authors.initials: HM
authors.lastname: Soylu
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .
authors.forename: Ozge
authors.initials: O
authors.lastname: Er
authors.affiliation: 3 Advanced Technology Research & Application Center, Mersin University , Mersin, Turkey .|4 Department of Energy Systems Engineering, Faculty of Technology, Mersin University , Tarsus/Mersin, Turkey .
authors.forename: Kasim
authors.initials: K
authors.lastname: Ocakoglu
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .
authors.forename: Fatma Yurt
authors.initials: FY
authors.lastname: Lambrecht
authors.affiliation: 5 Department of Laboratory Animal Science, Faculty of Medicine, Dokuz Eylul University , Izmir, Turkey .
authors.forename: Osman
authors.initials: O
authors.lastname: Yilmaz
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D007094:Imides / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D006845:Hydrocarbons, Fluorinated; D007094:Imides; D007457:Iodine Radioisotopes; C575299:bis(trifluoromethanesulfonyl)imide
keywords: 131I; biodistribution; imidazolium salts; nuclear medicine; radiolabeling