title: Guidelines for treatment of immune-mediated cerebellar ataxias.
abstract: Immune-mediated cerebellar ataxias include gluten ataxia, paraneoplastic cerebellar degeneration, GAD antibody associated cerebellar ataxia, and Hashimoto's encephalopathy. Despite the identification of an increasing number of immune-mediated cerebellar ataxias, there is no proposed standardized therapy. We evaluated the efficacies of immunotherapies in reported cases using a common scale of daily activity. The analysis highlighted the importance of removal of autoimmune triggering factors (e.g., gluten or cancer) and the need for immunotherapy evaluation (e.g., corticosteroids, intravenous immunoglobulin, immunosuppressants) and adaptation according to each subtype.
authors.affiliation: Department of Medical Education, Tokyo Medical University, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitoma
authors.affiliation: Academic Department of Neurosciences, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Marios
authors.initials: M
authors.lastname: Hadjivassiliou
authors.affiliation: University Lyon 1, University Lyon, Rue Guillaume Paradin, 69372 Lyon, Cedex 08 France ; INSERM, UMR-S1028, CNRS, UMR-5292, Lyon Neuroscience Research Center, Neuro-Oncology and Neuro-Inflammation Team, 7, Rue Guillaume Paradin, 69372 Lyon, Cedex 08 France ; National Reference Centre for Paraneoplastic Neurological Diseases, Hospices civils de Lyon, Hôpital neurologique, 69677 Bron, France ; Hospices Civils de Lyon, Neuro-oncology, Hôpital Neurologique, 69677 Bron, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Honnorat
keywords: Anti-GAD antibodies; Cerebellar ataxias; Gluten ataxia; Hashimoto’s encephalopathy; Immunotherapy; Paraneoplastic cerebellar degeneration