title: Myocardial infarction: stem cell transplantation for cardiac regeneration.
abstract: It is estimated that by 2030, almost 23.6 million people will perish from cardiovascular disease, according to the WHO. The review discusses advances in stem cell therapy for myocardial infarction, including cell sources, methods of differentiation, expansion selection and their route of delivery. Skeletal muscle cells, hematopoietic cells and mesenchymal stem cells (MSCs) and embryonic stem cells (ESCs)-derived cardiomyocytes have advanced to the clinical stage, while induced pluripotent cells (iPSCs) are yet to be considered clinically. Delivery of cells to the sites of injury and their subsequent retention is a major issue. The development of supportive scaffold matrices to facilitate stem cell retention and differentiation are analyzed. The review outlines clinical translation of conjugate stem cell-based cellular therapeutics post-myocardial infarction.
authors.affiliation: IITB Monash Research Academy, Indian Institute of Technology Bombay, Mumbai, India.
authors.forename: Edmund
authors.initials: E
authors.lastname: Carvalho
authors.affiliation: Turretfield Research Centre, South Australian Research & Development Institute (SARDI), SA, Australia.|Stem Cells & Reprogramming Group, Monash University, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Verma
authors.affiliation: FLAIR/Laboratory for Biomedical Engineering & Department of Mechanical & Aerospace Engineering, Monash University, Australia.
authors.forename: Kerry
authors.initials: K
authors.lastname: Hourigan
authors.affiliation: Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, India.
authors.forename: Rinti
authors.initials: R
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D012038:Regeneration; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology
keywords: bench to clinic; cardiac regeneration; myocardial infarction