title: Sphingosylphosphorylcholine in cancer progress.
abstract: Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid. It has been shown to exert multifunctional role in cell physiological regulation either as an intracellular second messenger or as an extracellular agent through G protein coupled receptors (GPCRs). Because of elevated levels of SPC in malicious ascites of patients with cancer, the role of SPC in tumor progression has prompted wide interest. The factor was reported to affect the proliferation and/or migration of many cancer cells, including pancreatic cancer cells, epithelial ovarian carcinoma cells, rat C6 glioma cells, neuroblastoma cells, melanoma cells, and human leukemia cells. This review covers current knowledge of the role of SPC in tumor.
authors.affiliation: Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University Jinan 250100, China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Yue
authors.affiliation: Institute of Poultry Science, Shandong Academy of Agricultural Sciences Jinan 250023, China.
authors.forename: Qing-Chuan
authors.initials: QC
authors.lastname: Jing
authors.affiliation: Department of Cardiology, Affiliated Hospital of Binzhou Medical University Yantai 264000, China.
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: Liu
authors.affiliation: Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University Jinan 250100, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University Jinan 250100, China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Li
authors.affiliation: Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University Jinan 250100, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
keywords: GPCRs; Sphingosylphosphorylcholine; cancer; second messenger