title: [Lymphocyte receptors that regulate the immune-response--the key to the management of antitumor immunity].
abstract: Tumor uses various mechanisms to "escape" from immune surveillance including the important role of dysregulation of interaction of signals from corresponding co-stimulatory and co-inhibitory receptors (so-called "control points immunity"-- immune "checkpoints") modulating T-cell activation process. A creation of targeted drugs impacting on immune "checkpoints"" is a new promising trend in modern oncoimmunology. This review is devoted to a brief characterization of some receptors of immune competent cells (such as activation and inhibitor), which play a crucial role in the interaction of the immune system and tumors as well as targeted drugs acting on them for therapeutic purpose.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Kadagidze
authors.forename: E G
authors.initials: EG
authors.lastname: Slavina
authors.forename: A I
authors.initials: AI
authors.lastname: Chertkova
mesh_terms: D000818:Animals; D060890:B7-H1 Antigen / Q000276:immunology; D053450:Glucocorticoid-Induced TNFR-Related Protein / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control*; D061026:Programmed Cell Death 1 Receptor / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology*; D053262:Receptors, OX40 / Q000276:immunology
chemical_list: D060890:B7-H1 Antigen; D053450:Glucocorticoid-Induced TNFR-Related Protein; D061026:Programmed Cell Death 1 Receptor; D011971:Receptors, Immunologic; D053262:Receptors, OX40; C491405:TNFRSF18 protein, human