title: Independent Control of Topography for 3D Patterning of the ECM Microenvironment.
abstract: Biomimetic extracellular matrix (ECM) topographies driven by the magnetic-field-directed self-assembly of ECM protein-coated magnetic beads are fabricated. This novel bottom-up method allows us to program isotropic, anisotropic, and diverse hybrid ECM patterns without changing other physicochemical properties of the scaffold material. It is demonstrated that this 3D anisotropic matrix is able to guide the dendritic protrusion of cells.
authors.affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute (NIH), Bethesda, MD, 20852, USA.
authors.forename: Jiyun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute (NIH), Bethesda, MD, 20852, USA.
authors.forename: Jack Rory
authors.initials: JR
authors.lastname: Staunton
authors.affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute (NIH), Bethesda, MD, 20852, USA.
authors.forename: Kandice
authors.initials: K
authors.lastname: Tanner
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D060833:Cellular Microenvironment / Q000187:drug effects*; D005109:Extracellular Matrix / Q000187:drug effects* / Q000378:metabolism; D060526:Magnetic Fields; D051379:Mice; D041681:NIH 3T3 Cells; D016716:PC12 Cells; D051381:Rats; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials
keywords: 3D biomaterials; biomimetic extracellular matrix; extracellular matrix topography; magnetic-field-directed self-assembly