title: Value of pre-operative breast MRI for the size assessment of ductal carcinoma in situ.
abstract: OBJECTIVE
  To retrospectively evaluate the accuracy of pre-operative breast MRI and mammography in determining the size of ductal carcinoma in situ (DCIS) compared with the histopathological results.
  
  
  METHODS
  79 patients [mean age: 56.5 (standard deviation 10.2) years] with pathologically proven DCIS (79 lesions) obtained a bilateral mammogram and a pre-operative contrast-enhanced MRI. The accuracy of MRI and mammography to detect tumour size were estimated and compared, using histopathological size as the gold standard, on the subjects with measurements with both modalities (n = 60).
  
  
  RESULTS
  MRI detected 67 (85%) lesions, mammography detected 72 (91%) and both modalities detected 60 (76%). Median DCIS size detected by mammography vs MRI was smaller (1.55 vs 1.65 cm). Out of these 60 cases, compared with the histopathological size, the accuracy of MRI and mammography was 0.66 and 0.56, respectively (p = 0.045). MRI showed better accuracy than mammography for younger patients (age ≤ 50 years, p = 0.003). For tumour nuclear grade, there was a statistically significant difference for the intermediate level, with higher accuracy for MRI (p = 0.03).
  
  
  CONCLUSIONS
  MRI was more accurate than mammography in DCIS size assessment when visible, particularly in lesions of intermediate grade and in patients less than 50 years of age.
  
  
  CONCLUSIONS
  Breast MRI may help in management of DCIS of intermediate grade and in females less than 50 years of age.
authors.affiliation: 1 Cedar Breast Clinic, McGill University Health Center, Royal Victoria Hospital, Montreal, QC, Canada.
authors.forename: Francesca
authors.initials: F
authors.lastname: Proulx
authors.affiliation: 2 Department of Mathematics and Statistics, McGill University, Montreal, QC, Canada.
authors.forename: José A
authors.initials: JA
authors.lastname: Correa
authors.affiliation: 1 Cedar Breast Clinic, McGill University Health Center, Royal Victoria Hospital, Montreal, QC, Canada.
authors.forename: Romuald
authors.initials: R
authors.lastname: Ferré
authors.affiliation: 3 Department of Pathology, Royal Victoria Hospital, Montreal, QC, Canada.
authors.forename: Atilla
authors.initials: A
authors.lastname: Omeroglu
authors.affiliation: 1 Cedar Breast Clinic, McGill University Health Center, Royal Victoria Hospital, Montreal, QC, Canada.
authors.forename: Ann
authors.initials: A
authors.lastname: Aldis
authors.affiliation: 1 Cedar Breast Clinic, McGill University Health Center, Royal Victoria Hospital, Montreal, QC, Canada.
authors.forename: Sarkis
authors.initials: S
authors.lastname: Meterissian
authors.affiliation: 1 Cedar Breast Clinic, McGill University Health Center, Royal Victoria Hospital, Montreal, QC, Canada.
authors.forename: Benoît
authors.initials: B
authors.lastname: Mesurolle
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology* / Q000601:surgery; D003287:Contrast Media; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography; D008875:Middle Aged; D009942:Organometallic Compounds; D057234:Preoperative Period; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol