title: Giant Intracranial Aneurysms at 7T MRI.
abstract: Giant intracranial aneurysms are rare vascular pathologies associated with high morbidity and mortality. The purpose of this in vivo study was to assess giant intracranial aneurysms and their wall microstructure by 7T MR imaging, previously only visualized in histopathologic examinations. Seven giant intracranial aneurysms were evaluated, and 2 aneurysms were available for histopathologic examination. Six of 7 (85.7%) showed intraluminal thrombus of various sizes. Aneurysm walls were depicted as hypointense in TOF-MRA and SWI sequences with excellent contrast ratios to adjacent brain parenchyma (range, 0.01-0.60 and 0.58-0.96, respectively). The triple-layered microstructure of the aneurysm walls was visualized in all aneurysms in TOF-MRA and SWI. This could be related to iron deposition in the wall, similar to the findings in 2 available histopathologic specimens. In vivo 7T TOF-MRA and SWI can delineate the aneurysm wall and the triple-layered wall microstructure in giant intracranial aneurysms.
authors.affiliation: From the Department of Neurosurgery (T.M., B.C., U.S., K.H.W.), University Hospital Essen, University Duisburg-Essen, Essen, Germany Department of Neurosurgery (T.M.), Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Erwin L. Hahn Institute for Magnetic Resonance Imaging (T.M., B.C., L.U., H.H.Q., K.H.W.), University Duisburg-Essen, Essen, Germany Toshinori.Matsushige@uk-essen.de.
authors.forename: T
authors.identifier: http://orcid.org/0000-0002-4446-7636
authors.initials: T
authors.lastname: Matsushige
authors.affiliation: From the Department of Neurosurgery (T.M., B.C., U.S., K.H.W.), University Hospital Essen, University Duisburg-Essen, Essen, Germany Erwin L. Hahn Institute for Magnetic Resonance Imaging (T.M., B.C., L.U., H.H.Q., K.H.W.), University Duisburg-Essen, Essen, Germany.
authors.forename: B
authors.identifier: http://orcid.org/0000-0002-7264-0010
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology (A.R., L.U., M.F.).
authors.forename: A
authors.identifier: http://orcid.org/0000-0002-8755-7076
authors.initials: A
authors.lastname: Ringelstein
authors.affiliation: Erwin L. Hahn Institute for Magnetic Resonance Imaging (T.M., B.C., L.U., H.H.Q., K.H.W.), University Duisburg-Essen, Essen, Germany Department of Diagnostic and Interventional Radiology and Neuroradiology (A.R., L.U., M.F.).
authors.forename: L
authors.identifier: http://orcid.org/0000-0001-5215-7171
authors.initials: L
authors.lastname: Umutlu
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology (A.R., L.U., M.F.).
authors.forename: M
authors.identifier: http://orcid.org/0000-0002-5584-9824
authors.initials: M
authors.lastname: Forsting
authors.affiliation: Erwin L. Hahn Institute for Magnetic Resonance Imaging (T.M., B.C., L.U., H.H.Q., K.H.W.), University Duisburg-Essen, Essen, Germany High Field and Hybrid MR Imaging (H.H.Q.), University Hospital Essen, Essen, Germany.
authors.forename: H H
authors.identifier: http://orcid.org/0000-0001-7964-0219
authors.initials: HH
authors.lastname: Quick
authors.affiliation: From the Department of Neurosurgery (T.M., B.C., U.S., K.H.W.), University Hospital Essen, University Duisburg-Essen, Essen, Germany.
authors.forename: U
authors.identifier: http://orcid.org/0000-0002-9073-1821
authors.initials: U
authors.lastname: Sure
authors.affiliation: From the Department of Neurosurgery (T.M., B.C., U.S., K.H.W.), University Hospital Essen, University Duisburg-Essen, Essen, Germany Erwin L. Hahn Institute for Magnetic Resonance Imaging (T.M., B.C., L.U., H.H.Q., K.H.W.), University Duisburg-Essen, Essen, Germany.
authors.forename: K H
authors.identifier: http://orcid.org/0000-0001-7076-3503
authors.initials: KH
authors.lastname: Wrede
mesh_terms: D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000473:pathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male