title: The interactome challenge.
abstract: The properties of living cells are mediated by a huge number of ever-changing interactions of their component macromolecules forming living machines; collectively, these are termed the interactome. Pathogenic alterations in interactomes mechanistically underlie diseases. Therefore, there exists an essential need for much better tools to reveal and dissect interactomes. This need is only now beginning to be met.
authors.affiliation: Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, WA 98109 Institute for Systems Biology, Seattle, WA 98109 rout@rockefeller.edu john.aitchison@cidresearch.org.
authors.forename: John D
authors.initials: JD
authors.lastname: Aitchison
authors.affiliation: Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY 10065 rout@rockefeller.edu john.aitchison@cidresearch.org.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Rout
mesh_terms: D006801:Humans; D025941:Protein Interaction Mapping; D060066:Protein Interaction Maps; D013597:Systems Analysis