title: Comparison of (18)F-FDG PET/CT and PET/MRI in patients with multiple myeloma.
abstract: PET/MRI represents a promising hybrid imaging modality with several potential clinical applications. Although PET/MRI seems highly attractive in the diagnostic approach of multiple myeloma (MM), its role has not yet been evaluated. The aims of this prospective study are to evaluate the feasibility of (18)F-FDG PET/MRI in detection of MM lesions, and to investigate the reproducibility of bone marrow lesions detection and quantitative data of (18)F-FDG uptake between the functional (PET) component of PET/CT and PET/MRI in MM patients. The study includes 30 MM patients. All patients initially underwent (18)F-FDG PET/CT (60 min p.i.), followed by PET/MRI (120 min p.i.). PET/CT and PET/MRI data were assessed and compared based on qualitative (lesion detection) and quantitative (SUV) evaluation. The hybrid PET/MRI system provided good image quality in all cases without artefacts. PET/MRI identified 65 of the 69 lesions, which were detectable with PET/CT (94.2%). Quantitative PET evaluations showed the following mean values in MM lesions: SUVaverage=5.5 and SUVmax=7.9 for PET/CT; SUVaverage=3.9 and SUVmax=5.8 for PET/MRI. Both SUVaverage and SUVmax were significantly higher on PET/CT than on PET/MRI. Spearman correlation analysis demonstrated a strong correlation between both lesional SUVaverage (r=0.744) and lesional SUVmax (r=0.855) values derived from PET/CT and PET/MRI. Regarding detection of myeloma skeletal lesions, PET/MRI exhibited equivalent performance to PET/CT. In terms of tracer uptake quantitation, a significant correlation between the two techniques was demonstrated, despite the statistically significant differences in lesional SUVs between PET/CT and PET/MRI.
authors.affiliation: Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ) Heidelberg, Germany.
authors.forename: Christos
authors.initials: C
authors.lastname: Sachpekidis
authors.affiliation: Department of Hematology and Oncology, University Hospital of Heidelberg Heidelberg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Hillengass
authors.affiliation: Department of Hematology and Oncology, University Hospital of Heidelberg Heidelberg, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Goldschmidt
authors.affiliation: Department of Radiology, German Cancer Research Center (DKFZ) Heidelberg, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Mosebach
authors.affiliation: Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ) Heidelberg, Germany.
authors.forename: Leyun
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Radiology, German Cancer Research Center (DKFZ) Heidelberg, Germany.
authors.forename: Heinz-Peter
authors.initials: HP
authors.lastname: Schlemmer
authors.affiliation: Division of Nuclear Medicine, University Clinic Heidelberg Heidelberg, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Haberkorn
authors.affiliation: Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ) Heidelberg, Germany.
authors.forename: Antonia
authors.initials: A
authors.lastname: Dimitrakopoulou-Strauss
keywords: Multiple myeloma; PET/CT; PET/MRI; SUV