title: [Occupational risk factors for lung cancer].
abstract: OBJECTIVE
  We aimed to review the literature regarding the dose-response relationship between occupational exposure to chemicals classified by the International Agency for Research on Cancer (IARC) as carcinogenic agents and the risk of some lung cancers and on any combined effect with tobacco exposure on lung cancer risk.
  
  
  METHODS
  A literature search was performed in three databases as well as in the IARC monographs between January 1990 and April 2015.
  
  
  RESULTS
  The literature is abundant for some carcinogens such as asbestos, crystalline silica and diesel exhaust fumes but is more sparse for many carcinogens and particularly any interaction with tobacco on lung cancer risk.
  
  
  CONCLUSIONS
  Few data exist for most lung occupational carcinogens including their interaction with tobacco exposure. In the case of exposure to occupational carcinogens and co-exposure to tobacco smoke, there is a dual primary prevention objective: the elimination of both occupational risk factors and tobacco smoke.
authors.affiliation: Institut Bergonié, 33000 Bordeaux, France; Institut de santé publique d'épidémiologie et de développement (ISPED), université de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux cedex, France; Unité Inserm 897, université de Bordeaux, 33000 Bordeaux, France. Electronic address: fleur.delva@isped.u-bordeaux2.fr.
authors.forename: F
authors.initials: F
authors.lastname: Delva
authors.affiliation: Service de pneumologie et pathologie professionnelle, centre hospitalier intercommunal de Créteil, 94000 Créteil, France; Département hospitalo-universitaire A-TVB, unité Inserm 955, 94000 Créteil, France; Institut santé travail Paris-Est, université Paris-Est, 94000 Créteil, France.
authors.forename: P
authors.initials: P
authors.lastname: Andujar
authors.affiliation: Institut de santé publique d'épidémiologie et de développement (ISPED), université de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux cedex, France; Unité Inserm 897, université de Bordeaux, 33000 Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Lacourt
authors.affiliation: Institut de santé publique d'épidémiologie et de développement (ISPED), université de Bordeaux, 146, rue Léo-Saignat, 33000 Bordeaux cedex, France; Unité Inserm 897, université de Bordeaux, 33000 Bordeaux, France; Service de médecine du travail, CHU de Bordeaux, 33000 Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Brochard
authors.affiliation: Service de pneumologie et pathologie professionnelle, centre hospitalier intercommunal de Créteil, 94000 Créteil, France; Département hospitalo-universitaire A-TVB, unité Inserm 955, 94000 Créteil, France; Institut santé travail Paris-Est, université Paris-Est, 94000 Créteil, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Pairon
mesh_terms: D002273:Carcinogens; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012307:Risk Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D014937:Work
chemical_list: D002273:Carcinogens; D014028:Tobacco Smoke Pollution
keywords: Agent cancérogène professionnel; Cancer bronchopulmonaire; Carcinogen; Co-exposition; Co-exposure; Facteur de risque; Fumée de tabac; Lung cancer; Risk factor; Tobacco smoke