title: [Influence of HIV infection on hepatitis C progress in patients co-infected with HIV/HCV].
abstract: OBJECTIVE
  To understand the influence of HIV infection on hepatitis C progress in patients co-infected with HIV and hepatitis C virus (HCV) and related immune mechanism.
  
  
  METHODS
  Twenty eight patients co-infected with HIV/HCV and 12 patients with simplex HCV infection were enrolled. The liver function and hepatic fibrosis progress were evaluated by detecting peripheral blood and with Fibro-Scan. The viral load of HCV was detected by using real time quantitative PCR. And the percentage of Treg/CD4⁺ T lymphocyte cell was tested by using flow cytometry.
  
  
  RESULTS
  The levels of ALT and ALP in HIV/HCV co-infection group were (76.16 ± 81.248) U/L, (24.507 1 ± 8.194) g/L respectively, higher than those of simplex HCV infection group [(27.475 0 ± 13.985) U/L, (16.966 7 ± 7.189) g/L], the differences were statistical significant. P value was 0.012 and 0.009 respectively. The liver fibrosis index in HIV/HCV co-infection group was 5.950 0-5.825 0 Kpa, higher than that in simplex HIV infection group (5.150 0-1.050 0 Kpa), and the difference was nearly statistical significant (P = 0.077). The HCV viral load in HIV/HCV co-infection group was (6.476 8-5.343 4) lg copy/ml, higher than that in simplex HCV infection group [(1.699 0-2.681 5) lg copy/ml], and the rate of HCV clearance in HIV/HCV co-infection group was 32.14%, lower than that in simplex HCV infection group (75.00%). P value was 0.012 and 0.032 respectively. The percentage of Treg/CD4⁺ T lymphocyte cell in HIV/HCV co-infection group was (7.460 0%-2.287 5%), higher than that in simplex HCV infection group (5.965 0%-2.105 0%), and the difference was significant (P = 0.032). The percentage of Treg/CD4⁺ T lymphocyte cell was significantly related with HCV viral load (ρ = 0.350, P = 0.027), and HCV viral load was significantly related with the liver fibrosis index (ρ = 0.487, P = 0.001).
  
  
  CONCLUSIONS
  HIV infection could accelerate the progress of hepatitis C, and Treg cells were involved in this progress.
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Liu
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Huanqin
authors.initials: H
authors.lastname: Sun
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Sun
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Guifang
authors.initials: G
authors.lastname: Qiao
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Na
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China; Email: 13810108505@163.com.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D015496:CD4-Positive T-Lymphocytes; D060085:Coinfection; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications*; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications / Q000821:virology*; D006801:Humans; D008103:Liver Cirrhosis / Q000821:virology; D019562:Viral Load