title: SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α.
abstract: Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy.
authors.affiliation: Institute of Pathology of Tongji Hospital and Department of Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Ao
authors.affiliation: Department of Pathology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Su
authors.affiliation: Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Guo
authors.affiliation: Institute of Pathology of Tongji Hospital and Department of Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cai
authors.affiliation: Department of Obstetrics &Gynecology, Central Hospital of Wuhan, Wuhan 430014, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology*; D003546:Cysteine Endopeptidases; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D010450:Endopeptidases / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics* / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism; D058207:Sumoylation
chemical_list: D000970:Antineoplastic Agents; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010450:Endopeptidases; C404512:SENP1 protein, human; D003546:Cysteine Endopeptidases; D002945:Cisplatin