title: Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis.
abstract: A mild, efficient, and practical transformation for the direct C-H trifluoromethylation of glycals under visible light has been reported for the first time. This reaction employed fac-Ir(3+)(ppy)3 as the photocatalyst, Umemoto's reagent as the CF3 source, and a household blue LED or sunlight as the light source. Glycals bearing both electron-withdrawing and -donating protective groups performed this reaction smoothly. This visible light-mediated trifluoromethylation reaction was highlighted by the trifluoromethylation of the biologically important Neu2en moiety.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, and Center for Molecular and Translational Medicine, Peking University , Xue Yuan Road No. 38, Beijing 100191, China.
authors.forename: Bang
authors.initials: B
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, and Center for Molecular and Translational Medicine, Peking University , Xue Yuan Road No. 38, Beijing 100191, China.
authors.forename: De-Cai
authors.initials: DC
authors.lastname: Xiong
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, and Center for Molecular and Translational Medicine, Peking University , Xue Yuan Road No. 38, Beijing 100191, China.
authors.forename: Xin-Shan
authors.initials: XS
authors.lastname: Ye
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D008027:Light; D008745:Methylation; D015394:Molecular Structure
chemical_list: D000475:Alkenes; D006027:Glycosides; D006845:Hydrocarbons, Fluorinated