title: Lymphocyte to monocyte ratio is associated with response to first-line platinum-based chemotherapy and prognosis of early-stage non-small cell lung cancer patients.
abstract: Lymphocyte to monocyte ratio (LMR) has shown prognostic value in different types of cancer. This study assessed the prognostic performance of LMR in early-stage non-small cell lung cancer (NSCLC) patients and investigated the influence of LMR on the treatment response in patients receiving first-line platinum-based chemotherapy. Four hundred eighty-eight NSCLC patients and 500 healthy donors were enrolled in this study. The cutoff value for LMR was chosen by receiver operating characteristic curve analysis. The prognostic significance of markers was assessed by univariate and multivariate Cox regression models. The median overall survival was 43 months, and the median progression-free survival was 38 months. LMR was associated with disease status and the treatment response of first-line platinum-based chemotherapy. Multivariate analysis showed that LMR was an independent prognostic factor for both overall survival (hazard ratio = 1.53, 95 % confidence interval = 1.09-2.14, P = 0.015) and progression-free survival (hazard ratio = 1.20, 95 % confidence interval = 1.02-1.67, P = 0.028). Furthermore, integration of LMR into a prognostic model including TNM stage, tumor status, chemotherapy, and histological type generated a nomogram, which predicted accurately overall survival for NSCLC patients. Decreased LMR may be a potential biomarker of disease status, worse response to first-line platinum-based chemotherapy, and worse survival for NSCLC patients. A prospective study is warranted for further validation of our findings.
authors.affiliation: Department of Respiratory Medicine, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, 223300, Jiangsu, China.
authors.forename: Ying-Jian
authors.initials: YJ
authors.lastname: Song
authors.affiliation: Department of Respiratory Medicine, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, 223300, Jiangsu, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, 223300, Jiangsu, China.
authors.forename: Yong-Qing
authors.initials: YQ
authors.lastname: Hong
authors.affiliation: Department of Gerontology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing West Road, Huai'an, 223300, Jiangsu, China.
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Lu
authors.affiliation: Department of Gerontology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing West Road, Huai'an, 223300, Jiangsu, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Tong
authors.affiliation: Department of Gerontology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing West Road, Huai'an, 223300, Jiangsu, China.
authors.forename: Xiao-Zheng
authors.initials: XZ
authors.lastname: Fang
authors.affiliation: Department of Gerontology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing West Road, Huai'an, 223300, Jiangsu, China. hayytan664@sohu.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Tan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology; D009367:Neoplasm Staging; D049451:Nomograms; D010984:Platinum / Q000008:administration & dosage*; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D010984:Platinum
keywords: Chemotherapy; Lymphocyte to monocyte ratio; NSCLC; Nomogram; Overall survival; Prognosis; Progression-free survival