title: Clinical implications of recent findings in schistosome proteomics.
abstract: Schistosomiasis is a neglected tropical disease of clinical significance that, despite years of research, still requires an effective vaccine and improved diagnostics for surveillance, control and potential elimination. Furthermore, the causes of host pathology during schistosomiasis are still not completely understood. The recent sequencing of the genomes of the three key schistosome species has enabled the discovery of many new possible vaccine and drug targets, as well as diagnostic biomarkers, using high-throughput and sensitive proteomics methods. This review focuses on the literature of the last 5 years that has reported on the use of proteomics to both better understand the biology of the schistosome parasites and the disease they cause in definitive mammalian hosts.
authors.affiliation: a QIMR Berghofer Medical Research Institute, Infectious Disease Division , Brisbane , Queensland , Australia.
authors.forename: Patrick
authors.initials: P
authors.lastname: Driguez
authors.affiliation: a QIMR Berghofer Medical Research Institute, Infectious Disease Division , Brisbane , Queensland , Australia.
authors.forename: Donald P
authors.initials: DP
authors.lastname: McManus
authors.affiliation: a QIMR Berghofer Medical Research Institute, Infectious Disease Division , Brisbane , Queensland , Australia.
authors.forename: Geoffrey N
authors.initials: GN
authors.lastname: Gobert
mesh_terms: D000818:Animals; D015801:Helminth Proteins / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D020543:Proteome / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism*; D040901:Proteomics; D012547:Schistosoma / Q000502:physiology*; D012552:Schistosomiasis / Q000175:diagnosis / Q000276:immunology / Q000469:parasitology*
chemical_list: D015801:Helminth Proteins; D020543:Proteome
keywords: Schistosomiasis; antigen discovery; diagnosis; drug target; immunoproteomics; proteomics; vaccine