title: Neuron-Specific Enolase, S100 Calcium-Binding Protein B, and Heat Shock Protein 70 Levels in Patients With Intracranial Hemorrhage.
abstract: The authors evaluated neuron-specific enolase (NSE), S100 calcium-binding protein B (S100B), and heat shock protein 70 (HSP 70) levels and their relationships with in-hospital mortality, Glasgow Coma Scale (GCS) scores, and National Institute of Health Stroke Scale (NIHSS) scores. In total, 35 patients older than 18 years were presented to our emergency department and were diagnosed with non-traumatic intracranial hemorrhage (ICH) and 32 healthy controls were included. Blood samples were drawn on days 0 and 5. S100 calcium-binding protein B and HSP levels were significantly higher in patients than in controls on days 0 and 5. Neuron-specific enolase levels were higher in patients than in controls on day 0, but there was no significant difference on day 5. S100 calcium-binding protein B was negatively correlated with GCS, whereas it was positively correlated with NIHSS and bleeding volume. There was also a negative correlation between NSE and GCS, but it was not statistically significant. In addition, no significant correlation was found in terms of bleeding volume or NIHSS. Heat shock protein 70 was negatively correlated with GCS and positively correlated with bleeding volume and NIHSS, but these results were not statistically significant. S100 calcium-binding protein B and HSP 70 levels were significantly higher in those who died compared with survivors. The areas under the curve of S100 B, NSE, and HSP 70 for mortality were 0.635, 0.477, and 0.770, respectively. Neuron-specific enolase, S100B, and HSP 70 levels are simple, inexpensive, and objective measures in cases of ICH. These tests can be used to support an assessment for screening ICH patients with clinical scoring systems, such as GCS and NIHSS.
authors.affiliation: From the Department of Emergency Medicine, Mugla Sitki Kocman University, Mugla (ODA, EA); Department of Emergency Medicine (MG, MA, MY); Department of Neurology, Firat University, Medicine School, Elazig (CFD); Department of Emergency Medicine, Batman Region State Hospital, Batman (EE); Department of Biochemistry, Elazig Training Hospital (MK); and Department of Biochemistry, Firat University, Medicine School, Elazig, Turkey (NI).
authors.forename: Ömer Doğan
authors.initials: ÖD
authors.lastname: Alatas
authors.forename: Mehtap
authors.initials: M
authors.lastname: Gürger
authors.forename: Metin
authors.initials: M
authors.lastname: Ateşçelik
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildiz
authors.forename: Caner Feyzi
authors.initials: CF
authors.lastname: Demir
authors.forename: Evren
authors.initials: E
authors.lastname: Ekingen
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kalayci
authors.forename: Nevin
authors.initials: N
authors.lastname: Ilhan
authors.forename: Ethem
authors.initials: E
authors.lastname: Acar
mesh_terms: D000046:Academic Medical Centers; D000368:Aged; D015415:Biomarkers; D005260:Female; D015600:Glasgow Coma Scale; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D017052:Hospital Mortality; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011379:Prognosis; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*
chemical_list: D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins; D064568:S100 Calcium Binding Protein beta Subunit; D010751:Phosphopyruvate Hydratase