title: Potential diagnostic markers for disseminated intravascular coagulation of sepsis.
abstract: Disseminated intravascular coagulation (DIC) is an acquired thrombo-haemorrhagic disorder which arises in clinical scenarios like sepsis, trauma and malignancies. The clinic-laboratory diagnosis of DIC is made in a patient who develops the combination of laboratory abnormalities in the appropriate clinical scenario. The most common laboratory parameters in this setting have been the clotting profile, platelet count, serum fibrinogen and fibrin degradation markers. These tests had the advantage that they could be performed easily and in most laboratories. However, with the better understanding of the pathophysiology of DIC, in recent years, more specific tests have been suggested to be useful in this setting. The newer tests can also prove to be useful in prognostication in DIC. In addition, they may provide assistance in the selection and monitoring of patients diagnosed with DIC.
authors.affiliation: Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Iba
authors.affiliation: Department of Emergency and Critical Care Medicine, Kagoshima, University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; Department of Systems Biology in Thromboregulation, Kagoshima, University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Systems Biology in Thromboregulation, Kagoshima, University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Ikuro
authors.initials: I
authors.lastname: Maruyama
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
authors.forename: Bernd
authors.initials: B
authors.lastname: Jilma
authors.affiliation: Department of Anaesthesiology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Brenner
authors.affiliation: Department of Intensive Care, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: Marcella C A
authors.initials: MC
authors.lastname: Müller
authors.affiliation: Department of Intensive Care, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: Nicole P
authors.initials: NP
authors.lastname: Juffermans
authors.affiliation: Department of Haematology, Manchester Royal Infirmary, Manchester, United Kingdom. Electronic address: jecko.thachil@cmft.nhs.uk.
authors.forename: Jecko
authors.initials: J
authors.lastname: Thachil
mesh_terms: D000071120:ADAMTS13 Protein / Q000097:blood / Q000378:metabolism; D000925:Anticoagulants / Q000097:blood / Q000378:metabolism; D015415:Biomarkers; D001780:Blood Coagulation Tests / Q000379:methods / Q000592:standards; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D018805:Sepsis / Q000150:complications*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D015415:Biomarkers; D014841:von Willebrand Factor; D000071120:ADAMTS13 Protein
keywords: Antithrombin; Coagulation; Disseminated intravascular coagulation; High mobility group box protein; Histones; Protein C; Thrombomodulin; Von willebrand factor