title: T cell immunity to dengue virus and implications for vaccine design.
abstract: Dengue virus infections are increasing at an alarming rate in many tropical and subtropical countries and represent, in some of these areas, a leading cause of hospitalization and death among children. The lack of a clear definition of the correlates of protection from severe dengue disease represents a major hurdle for vaccine development. In particular, the role of T lymphocytes during dengue infection remains unclear and there is evidence suggesting that these cells may be important for both protective immunity and/or immunopathology. In this review we discuss the findings that support a protective role of T cells versus those supporting their involvement in pathogenesis. A better understanding of T cell immunity is urgently needed for the development of safe and efficacious vaccines.
authors.affiliation: a Program in Emerging Infectious Diseases , Duke-NUS Graduate Medical School , Singapore.
authors.forename: Laura
authors.initials: L
authors.lastname: Rivino
mesh_terms: D000818:Animals; D003715:Dengue / Q000276:immunology* / Q000473:pathology* / Q000517:prevention & control; D053059:Dengue Vaccines / Q000276:immunology / Q000302:isolation & purification*; D003716:Dengue Virus / Q000276:immunology*; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D053059:Dengue Vaccines
keywords: DENV; T cell epitopes; T cells; immunopathology; primary infection; protective immunity; secondary infection; vaccines