title: Down-RANKing the Threat of HSV-1: RANKL Upregulates MHC-Class-I-Restricted Anti-Viral Immunity in Herpes Simplex Virus Infection.
abstract: Herpes simplex virus (HSV-1) is a major cause of viral skin infection in humans. Klenner and colleagues now show that the epidermal receptor activator of NFκB ligand (RANKL) is critical for the induction of anti-viral CD8(+) effector T cells (CTL) during cutaneous HSV-1 infection. Activation via RANKL prevents Langerhans cell apoptosis, thus leading to enhanced antigen transport to regional lymph nodes, increasing the CTL-priming capacity of lymph node dendritic cells.
authors.affiliation: Departments of Dermatology and Academic Wound Healing, Institute of Infection and Immunity, Cardiff University and University Hospital of Wales, Heath Park, Cardiff, UK.
authors.forename: Katja
authors.initials: K
authors.lastname: Finsterbusch
authors.affiliation: Departments of Dermatology and Academic Wound Healing, Institute of Infection and Immunity, Cardiff University and University Hospital of Wales, Heath Park, Cardiff, UK. Electronic address: piguetv@cardiff.ac.uk.
authors.forename: Vincent
authors.initials: V
authors.lastname: Piguet
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology*; D053245:RANK Ligand / Q000276:immunology*; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000276:immunology*
chemical_list: D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B