title: Synergetic catalysis based on the proline tailed metalloporphyrin with graphene sheet as efficient mimetic enzyme for ultrasensitive electrochemical detection of dopamine.
abstract: In this paper, linking with the butoxycarbonyl (BOC) protection of proline, a new tailed metalloporphyrin with many useful active functions, nickel (II) 5-[4-N-(tert-Butoxycarbonyl)-l-prolinecoxylpropyloxy]phenyl-10,15,20-triphenylporphyrin (NiTBLPyP), was designed and synthesized. And the NiTBLPyP polymer (poly(NiTBLPyP)) was successfully obtained via a low-cost electrochemical method and exploited as an efficient mimic enzyme. Subsequently, a noncovalent nanohybrid of poly(NiTBLPyP) with graphene (rGO) sheet (rGO-poly(NiTBLPyP)) was prepared through π-π stacking interaction for the ultrasensitive and selective detection of DA. The nanohybrid was characterized by UV-vis spectroscopy, Fourier transform infrared spectra, Raman spectroscopy, scanning electron microscopy and electrochemical impedance spectroscopy. Due to the excellent electrocatalytic ability of poly(NiTBLPyP) film and aromatic π-π stacking interaction between poly(NiTBLPyP and rGO sheet, the obtained rGO-poly(NiTBLPyP) film exhibited a great synergistic amplification effect toward dopamine oxidation. Under optimum experimental conditions, the logarithm of catalytic currents showed a good linear relationship with that of the dopamine concentration in the range of 0.01-200 μM with a low detection limit of 1.40 nM. With good sensitivity and selectivity, the present method was applied to the determination of DA in real sample and the results was satisfactory. Thus, the rGO-poly(NiTBLPyP) film is one of the promising mimetic enzyme for electrocatalysis and relevant fields.
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Yan
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Gu
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Tang
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zheng
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Yaru
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: zzq@jlu.edu.cn.
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Breast Surgery, First Hospital, Jilin University, Changchun 130012, China. Electronic address: yangming1967@163.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D002384:Catalysis; D003217:Conductometry / Q000295:instrumentation*; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry; D004298:Dopamine / Q000032:analysis* / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006108:Graphite / Q000737:chemistry*; D008665:Metalloporphyrins / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D008665:Metalloporphyrins; D006108:Graphite; D003577:Cytochrome P-450 Enzyme System; D011392:Proline; D004298:Dopamine
keywords: Dopamine; Graphene; Proline; Synergistic effect; Tailed metalloporphyrin