title: Comparison of the anti-inflammatory effect of dexamethasone and ketorolac in the extractions of third molars.
abstract: This double-blind, split-mouth, and randomized study was aimed to compare the efficacy of dexamethasone and ketorolac tromethamine, through the evaluation of pain, edema, and limitation of mouth opening. Thirty-four individuals aged 18-26 years, having bilateral mandibular third molars, in a similar position, were selected. Two different surgical procedures were performed on the same individual by the single surgeon. For an extraction, the individual received 1 capsule of 10 mg ketorolac tromethamine 1 h before surgery and every 8 h for 2 days. For the extraction of the contralateral side, the individual received 1 capsule of 8 mg dexamethasone 1 h before surgery and 1 placebo capsule every 8 h for 2 days. Sodium metamizol, 500 mg, was given as rescue medication in postoperative. Pain was assessed by the Visual Box Scale-11 points (BS-11) at 24 h postoperative. Edema (metric measurement) and the maximum mouth opening (interincisal) were recorded in the pre-operative, 24 h, 48 h, 72 h and 7 days postoperatively. The results showed that both therapeutic treatments used were effective in the postoperative, and there were no statistically significant differences between the groups for the pain and edema variables. However, for the limitation of mouth opening, 24 h and 7 days postoperatively, the dexamethasone group had a lower limitation of mouth opening, behaving better than the ketorolac for this variable in these periods. Due also to the higher margin of safety, the use of dexamethasone as a single dose becomes a more suitable alternative for use in routine surgical extractions of third molars.
authors.affiliation: Program in Health Science and Development of the Midwest Region of the Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil. jgpaivaoliveira@gmail.com.
authors.forename: Janayna Gomes
authors.identifier: http://orcid.org/0000-0003-2090-2872
authors.initials: JG
authors.lastname: Paiva-Oliveira
authors.affiliation: Program in Health Science and Development of the Midwest Region of the Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Paulo Roberto Haidamus Oliveira
authors.initials: PR
authors.lastname: Bastos
authors.affiliation: Program in Health Science and Development of the Midwest Region of the Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Elenir R J
authors.initials: ER
authors.lastname: Cury Pontes
authors.affiliation: Faculty of Dentistry, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Júlio César Leite
authors.initials: JC
authors.lastname: da Silva
authors.affiliation: Faculty of Dentistry, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Jéssica Andréa Berto
authors.initials: JA
authors.lastname: Delgado
authors.affiliation: Faculty of Dentistry, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
authors.forename: Nelson Talatoci
authors.initials: NT
authors.lastname: Oshiro-Filho
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004177:Dipyrone / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004487:Edema / Q000209:etiology; D005260:Female; D006801:Humans; D020911:Ketorolac Tromethamine / Q000627:therapeutic use*; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D011292:Premedication; D014081:Tooth Extraction; D016896:Treatment Outcome; D014313:Trismus / Q000209:etiology; D064232:Visual Analog Scale; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D020911:Ketorolac Tromethamine; D004177:Dipyrone; D003907:Dexamethasone
keywords: Analgesia preemptive; Dexamethasone; Ketorolac; Third molar