title: Fosfomycin tromethamine. Antibiotic of choice in the female patient: A multicenter study.
abstract: BACKGROUND
  The aim of this study was to evaluate oral single/multiple doses of Fosfomycin Trometamol with clinical and microbiological efficacy in:Asymptomatic bacteriuria in pregnancy.Endourological procedures.Lower urinary tract infections.
  
  
  METHODS
  This prospective, uncontrolled, open label study was conducted in two tertiary hospitals over a period of three years. A total of 400 patients were included in the study. Group A (200 patients) with asymptomatic bacteriuria in pregnancy and Group B (200 Patients) with symptomatic lower urinary tract infections and with any day care endourological procedures were enrolled in our study. Efficacy end points like post- antibiotic urinalysis, microbiological efficacy and clinical improvement with adverse effects of the drug were evaluated.
  
  
  RESULTS
  Of the 400 patients studied, 98% returned for follow-up. Out of the 304 urinary isolates in Table 2 (ASB and symptomatic LUTS) grown on urinary culture, majority of the isolates were Gram-negative Enterobacteriacae family. After oral single/multiple doses of fosfomycin, bacterial eradication, bacterial persistence, bacterial reinfection were 96.3%, 3.9%, 3.9% respectively (Figure 2). No isolates were grown in 8 cases (Table 2). However, on administration of the drug 23.5% patients noticed diarrhea (loose stools) followed by itching (19.7%) in genital area (Figure 1).
  
  
  CONCLUSIONS
  Fosfomycin Trometamol is a bactericidal antibiotic with a broad spectrum activity against Gram-positive also Gram-negative bacteriae. It has an advantage of oral single /multiple doses, higher eradication rate of bacteria after 48 hours, excellent tolerability and safety in pregnancy and other female age groups. We recommend Fosfomycin Trometamol as the drug of choice particularly in patients with poor drug compliance and for minor day care endourological procedures.
authors.affiliation: Sheri Kashmir Institute of Medical Sciences Soura Srinagar; Government Medical College Srinagar Jammu and Kashmir, India.
authors.forename: Abdul Rouf
authors.initials: AR
authors.lastname: Khawaja
authors.affiliation: Sheri Kashmir Institute of Medical Sciences Soura Srinagar; Government Medical College Srinagar Jammu and Kashmir, India.
authors.forename: Farzana Bashir
authors.initials: FB
authors.lastname: Khan
authors.affiliation: Sheri Kashmir Institute of Medical Sciences Soura Srinagar; Government Medical College Srinagar Jammu and Kashmir, India.
authors.forename: Tanveer Iqbal
authors.initials: TI
authors.lastname: Dar
authors.affiliation: Sheri Kashmir Institute of Medical Sciences Soura Srinagar; Government Medical College Srinagar Jammu and Kashmir, India.
authors.forename: Arif Hameed
authors.initials: AH
authors.lastname: Bhat
authors.affiliation: Sheri Kashmir Institute of Medical Sciences Soura Srinagar; Government Medical College Srinagar Jammu and Kashmir, India.
authors.forename: Mohd Saleem
authors.initials: MS
authors.lastname: Wani
authors.affiliation: Sheri Kashmir Institute of Medical Sciences Soura Srinagar; Government Medical College Srinagar Jammu and Kashmir, India.
authors.forename: Baldev Singh
authors.initials: BS
authors.lastname: Wazir
keywords: asymptomatic bacteriuria (ASB); fosfomycin trometamol; lower urinary tract symptoms; urinary tract infections