title: [INVESTIGATIONS OF SUBMICROSCOPIC ARCHITECTONICS SERTOLI AND LEYDIG CELLS AFTER HYDROCHLORIDE SEROTONIN DESTRUCTIVE IMPACT AND THE POSSIBILITY OF CORRECTION BY STIMULANTS OF METABOLIC PROCESSES].
abstract: The results of study of ultrastructural changes in the Sertoli cells and Leydig's cells organelles after destructive influence of the serotonin hydrochloride and under influence bioglobin-U have been presented. It was shown that serotonin hydrochloride causes mitochondrial dysfunction and activates intracellular catabolic processes on the intracellular level. Bioglobin-U increases the activity and reparative synthetic reactions, reduced the degree of mitochondrial dysfunction and catabolic processes and activate the Leydig cell metabolism, and significantly reduces the number of foci destruction membranes of the endoplasmic reticulum, mitochondrial, and membranes of nucleus on the background of serotonin hydrochloride.
authors.forename: N
authors.initials: N
authors.lastname: Brechka
authors.forename: V
authors.initials: V
authors.lastname: Nevzorov
authors.forename: V
authors.initials: V
authors.lastname: Bondarenko
authors.forename: N
authors.initials: N
authors.lastname: Malova
authors.forename: N
authors.initials: N
authors.lastname: Selyukova
mesh_terms: D000818:Animals; D001284:Atrophy / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D001685:Biological Factors / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy / Q000473:pathology; D007425:Intracellular Membranes / Q000187:drug effects / Q000648:ultrastructure; D007985:Leydig Cells / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D010920:Placenta / Q000737:chemistry; D011247:Pregnancy; D011492:Protein Hydrolysates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000009:adverse effects*; D012708:Sertoli Cells / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D001685:Biological Factors; D011492:Protein Hydrolysates; D012701:Serotonin