title: Speckle-Tracking Echocardiography to Detect Cardiac Toxicity in Children Who Received Anthracyclines During Pregnancy.
abstract: Cardiac toxicities remain a possible risk to fetuses that received anthracyclines during pregnancy. The introduction of new echocardiographic techniques will improve the detection of early cardiac damage. Thus, we began a observational study using speckle-tracking echocardiography (STE) in children who had received anthracyclines during pregnancy, including the first trimester. From 2009 to 2013, we performed STE on patients > 5 years old, whose mothers had received anthracyclines during pregnancy. Siblings or cousins of equivalent age and gender were used as the control group. A total of 90 children fulfilled the entry criteria. Our results with STE were normal in all echocardiography parameters and did not show any differences when compared with the findings from the control group. We consider that the use of anthracyclines during pregnancy does not produce cardiac damage in newborns and can be safely administered, because no cardiac toxicity was evident in these children and it is of benefit to the mother.
authors.affiliation: Oncology Research Unit, Oncology Hospital National Medical Center, IMSS, Mexico City, Mexico. Electronic address: aamiranda12@gmail.com.
authors.forename: Agustin
authors.initials: A
authors.lastname: Avilès
authors.affiliation: Hematology Department, Oncology Hospital National Medical Center, IMSS, Mexico City, Mexico.
authors.forename: Marìa-Jesus
authors.initials: MJ
authors.lastname: Nambo
authors.affiliation: Hematology Department, Oncology Hospital National Medical Center, IMSS, Mexico City, Mexico.
authors.forename: Judith
authors.initials: J
authors.lastname: Huerta-Guzmàn
authors.affiliation: Hematology Department, Oncology Hospital National Medical Center, IMSS, Mexico City, Mexico.
authors.forename: Natividad
authors.initials: N
authors.lastname: Neri
authors.affiliation: Hematology Department, Oncology Hospital National Medical Center, IMSS, Mexico City, Mexico.
authors.forename: Sergio
authors.initials: S
authors.lastname: Cleto
mesh_terms: D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000009:adverse effects* / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D066126:Cardiotoxicity / Q000000981:diagnostic imaging / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography / Q000379:methods; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011261:Pregnancy Trimester, First / Q000187:drug effects; D055815:Young Adult
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic
keywords: Anthracyclines; Cardiac toxicity; Echocardiogram; Hematologic malignancies; Hodgking lymphoma and pregnancy; Lymphoma and pregnancy