title: Performance of a Novel Point-of-Care Molecular Assay for Detection of Influenza A and B Viruses and Respiratory Syncytial Virus (Enigma MiniLab) in Children with Acute Respiratory Infection.
abstract: The performance of the Enigma MiniLab assay for influenza A and B viruses and respiratory syncytial virus (RSV) was compared to a centralized laboratory respiratory virus panel. The positive and negative percent agreement for influenza A virus, influenza B virus, and RSV were 79.2% (95% confidence interval [95% CI], 57.8 to 92.9%) and 99.4% (95% CI, 98.4 to 99.9), 100% (95% CI, 47.8 to 100%) and 100% (95% CI, 99.3 to 100%), 98.5% (95% CI, 94.6 to 99.8%) and 94.5% (95% CI, 91.9 to 96.4%), respectively.
authors.affiliation: Centre for Clinical Infection and Diagnostics Research, King's College, and Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
authors.forename: Sam T
authors.initials: ST
authors.lastname: Douthwaite
authors.affiliation: Centre for Clinical Infection and Diagnostics Research, King's College, and Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Walker
authors.affiliation: Aquarius Population Health Limited, London, United Kingdom School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
authors.forename: Elisabeth J
authors.initials: EJ
authors.lastname: Adams
authors.affiliation: Aquarius Population Health Limited, London, United Kingdom.
authors.forename: Catherine
authors.initials: C
authors.lastname: Mak
authors.affiliation: Aquarius Population Health Limited, London, United Kingdom Department of International Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
authors.forename: Andres
authors.initials: A
authors.lastname: Vecino Ortiz
authors.affiliation: Department of Paediatric Infectious Diseases, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
authors.forename: Nuria
authors.initials: N
authors.lastname: Martinez-Alier
authors.affiliation: Centre for Clinical Infection and Diagnostics Research, King's College, and Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom Simon.goldenberg@gstt.nhs.uk.
authors.forename: Simon D
authors.initials: SD
authors.lastname: Goldenberg
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification*; D009981:Influenza B virus / Q000302:isolation & purification*; D008297:Male; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D019095:Point-of-Care Systems; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification*; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000821:virology*