title: [The diagnosis of latent tuberculosis infection in children in XXI century. Is tuberculin skin test still up to date?].
abstract: Tuberculosis morbidity rates in Poland have been gradually decreasing. Nevertheless, there are approximately 8 thousand cases being registered annually, which includes almost 3 thousand massively infectious patients. In the last 3 years, around 100 cases/year have been reported among children below 14 years of age. Infection with Mycobacterium tuberculosis should be considered in all patients who present symptoms suggesting tuberculosis, have had recent contact with a person suffering from lung tuberculosis or are planned to undergo an immunosuppressive treatment. HIV infected patients are also supposed to have screening tests for M. tuberculosis infection performed. For over a 100 years tuberculin skin test (TST) was the only test capable of confirming tuberculous infection. TST is based on the assessment of skin reaction to intracutaneous injection of tuberculin. Due to cross-reaction to the injected tuberculin in BCG vaccinated individuals, the correct interpretation of the test is difficult. Since 13 years new immunological assays have been available. They are based on detecting interferon gamma (Interferon Gamma Release Assay - IGRA) concentration in blood serum, which has previously been incubated with Mycobacterium tuberculosis antigens absent in the BCG strain. In infected individuals interferon gamma is intensively produced by memory cells in reaction to the contact with previously met Mycobacterium antigens. Many trials have proved IGRA's high sensitivity and, higher than TST, specificity. Recent guidelines promote the usage of IGRAs, even in children.
authors.affiliation: Klinika Pneumonologii i Alergologii Wieku Dziecięcego, Warszawski Uniwersytet Medyczny.
authors.forename: Teresa
authors.initials: T
authors.lastname: Bielecka
authors.affiliation: Klinika Pneumonologii i Alergologii Wieku Dziecięcego, Warszawski Uniwersytet Medyczny.
authors.forename: Anna
authors.initials: A
authors.lastname: Komorowska-Piotrowska
authors.affiliation: Klinika Pneumonologii i Alergologii Wieku Dziecięcego, Warszawski Uniwersytet Medyczny.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Mazur
authors.affiliation: Klinika Pneumonologii i Alergologii Wieku Dziecięcego, Warszawski Uniwersytet Medyczny.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Feleszko
mesh_terms: D000293:Adolescent; D000942:Antigens, Bacterial / Q000276:immunology; D001500:BCG Vaccine / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D059425:Interferon-gamma Release Tests; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000276:immunology; D011044:Poland; D012680:Sensitivity and Specificity; D014374:Tuberculin Test
chemical_list: D000942:Antigens, Bacterial; D001500:BCG Vaccine; C072681:Mycobacterium tuberculosis antigens