title: Polymorphisms of three genes (ACE, AGT and CYP11B2) in the renin-angiotensin-aldosterone system are not associated with blood pressure salt sensitivity: A systematic meta-analysis.
abstract: Many studies have suggested that polymorphisms of three key genes (ACE, AGT and CYP11B2) in the renin-angiotensin-aldosterone system (RAAS) play important roles in the development of blood pressure (BP) salt sensitivity, but they have revealed inconsistent results. Thus, we performed a meta-analysis to clarify the association. PubMed and Embase databases were searched for eligible published articles. Fixed- or random-effect models were used to pool odds ratios and 95% confidence intervals based on whether there was significant heterogeneity between studies. In total, seven studies [237 salt-sensitive (SS) cases and 251 salt-resistant (SR) controls] for ACE gene I/D polymorphism, three studies (130 SS cases and 221 SR controls) for AGT gene M235T polymorphism and three studies (113 SS cases and 218 SR controls) for CYP11B2 gene C344T polymorphism were included in this meta-analysis. The results showed that there was no significant association between polymorphisms of these three polymorphisms in the RAAS and BP salt sensitivity under three genetic models (all p > 0.05). The meta-analysis suggested that three polymorphisms (ACE gene I/D, AGT gene M235T, CYP11B2 gene C344T) in the RAAS have no significant effect on BP salt sensitivity.
authors.affiliation: a Departments of Epidemiology and Health Statistics ;
authors.forename: Jiahong
authors.initials: J
authors.lastname: Sun
authors.affiliation: b Nutrition and Food Hygiene, School of Public Health , Shandong University , Jinan , PR China ;
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: c Department of Health Inspection, Shandong Medical College , Jinan , PR China.
authors.forename: Song
authors.initials: S
authors.lastname: Miao
authors.affiliation: a Departments of Epidemiology and Health Statistics ;
authors.forename: Bo
authors.initials: B
authors.lastname: Xi
mesh_terms: D000808:Angiotensinogen / Q000235:genetics*; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D016022:Case-Control Studies; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D008957:Models, Genetic; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000187:drug effects*; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
chemical_list: C534931:AGT protein, human; D017673:Sodium Chloride, Dietary; D000808:Angiotensinogen; D019405:Cytochrome P-450 CYP11B2; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: ACE; AGT; CYP11B2; blood pressure salt sensitivity; polymorphism