title: Evaluating differential effects using regression interactions and regression mixture models.
abstract: Research increasingly emphasizes understanding differential effects. This paper focuses on understanding regression mixture models, a relatively new statistical methods for assessing differential effects by comparing results to using an interactive term in linear regression. The research questions which each model answers, their formulation, and their assumptions are compared using Monte Carlo simulations and real data analysis. The capabilities of regression mixture models are described and specific issues to be addressed when conducting regression mixtures are proposed. The paper aims to clarify the role that regression mixtures can take in the estimation of differential effects and increase awareness of the benefits and potential pitfalls of this approach. Regression mixture models are shown to be a potentially effective exploratory method for finding differential effects when these effects can be defined by a small number of classes of respondents who share a typical relationship between a predictor and an outcome. It is also shown that the comparison between regression mixture models and interactions becomes substantially more complex as the number of classes increases. It is argued that regression interactions are well suited for direct tests of specific hypotheses about differential effects and regression mixtures provide a useful approach for exploring effect heterogeneity given adequate samples and study design.
authors.affiliation: University of South Carolina.
authors.forename: M Lee
authors.initials: ML
authors.lastname: Van Horn
authors.affiliation: Lancaster University.
authors.forename: Thomas
authors.initials: T
authors.lastname: Jaki
authors.affiliation: Harvard University.
authors.forename: Katherine
authors.initials: K
authors.lastname: Masyn
authors.affiliation: George Washington University.
authors.forename: George
authors.initials: G
authors.lastname: Howe
authors.affiliation: University of Miami.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Feaster
authors.affiliation: University of South Carolina.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Lamont
authors.affiliation: University of South Carolina.
authors.forename: Melissa R W
authors.initials: MR
authors.lastname: George
authors.affiliation: University of South Carolina.
authors.forename: Minjung
authors.initials: M
authors.lastname: Kim