title: CTLA-4 Ig as an effective treatment in a patient with type I diabetes mellitus and seropositive rheumatoid arthritis.
abstract: We describe a patient suffering from seropositive rheumatoid arthritis (RA) and type I diabetes mellitus (T1DM), who achieved a good EULAR response together with an improvement of the glycemic profile under treatment with CTLA-4 Ig. A close association is known to exist between T1DM and RA, and CTLA-4 exon 1 polymorphism has been associated to RA with coexisting autoimmune endocrinopathies. The possible common genetic background and the potential role of CTLA-4 Ig in the early phases of T1DM, could be considered in the therapeutic interventions in RA patients with type 1 diabetes.
authors.affiliation: Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Anna Laura
authors.initials: AL
authors.lastname: Fedele
authors.affiliation: Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Alivernini
authors.affiliation: Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Gremese
authors.affiliation: Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy. gff1990@gmail.com.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Ferraccioli
mesh_terms: D000069594:Abatacept / Q000235:genetics / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D000069594:Abatacept