title: Phenolic Compounds from the Flowers of Bombax malabaricum and Their Antioxidant and Antiviral Activities.
abstract: Three new phenolic compounds 1-3 and twenty known ones 4-23 were isolated from the flowers of Bombax malabaricum. Their chemical structures were elucidated by spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D- and 2D-NMR) and chemical reactions. The antioxidant capacities of the isolated compounds were tested using FRAP and DPPH radical-scavenging assays, and compounds 4, 6, 8, 12, as well as the new compound 2, exhibited stronger antioxidant activities than ascorbic acid. Furthermore, all of compounds were tested for their antiviral activities against RSV by the CPE reduction assay and plaque reduction assay. Compounds 4, 10, 12 possess in vitro antiviral activities, and compound 10 exhibits potent anti-RSV effects, comparable to the positive control ribavirin.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. ybzhang99@126.com.|Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, China. ybzhang99@126.com.
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. yanknow@163.com.|International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. yanknow@163.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. gzleijie@gmail.com.|Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, China. gzleijie@gmail.com.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. summerxc123456@gmail.com.|Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, China. summerxc123456@gmail.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Xia
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. liguoqiang@jnu.edu.cn.
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. chyewc@gmail.com.
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. twangguocai@jnu.edu.cn.|Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, China. twangguocai@jnu.edu.cn.
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. tliyl@jnu.edu.cn.|Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, China. tliyl@jnu.edu.cn.
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D035163:Bombax / Q000737:chemistry*; D002460:Cell Line; D035264:Flowers / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018113:Respiratory Syncytial Virus, Human / Q000187:drug effects
chemical_list: D000975:Antioxidants; D000998:Antiviral Agents; D010636:Phenols; D010936:Plant Extracts
keywords: Bombax malabaricum; antioxidant activity; antiviral activity; phenolic compounds; structure identification