title: The Tolerability and Efficacy of a Three-product Anti-aging Treatment Regimen in Subjects with Moderate-to-severe Photodamage.
abstract: Retinoids and alpha hydroxy acids differ in mechanism of action for treatment of photodamage, but concurrent use may produce a synergistic effect by combining retinoid-induced normalization of cellular differentiation with alpha hydroxy acid-induced exfoliation (in hydrophilic areas) and enhanced dermal and epidermal hydration. A recent bioengineered molecule, ethyl lactyl retinoate (alpha hydroxy acid retinoid conjugate), is the first to deliver alpha hydroxy acids and retinoids together in a hydrolysis-based time-released fashion. This could improve efficacy while minimizing irritation commonly associated with retinoid use. An eight-week clinical study was conducted to examine the efficacy and tolerability of this formulation; 25 women aged 54.1 ±8.9 years (mean ± SD) with moderate-to-severe photodamage (as determined by physician investigators using the Glogau Wrinkle Scale) employed a twice-daily regimen of cleanser (7.8% 1-lactic acid, 2% salicylic acid) and anti-aging serum (0.1% alpha hydroxy acids-retinoids, 6.5% 1-lactic acid) with concurrent use of sun protection factor 50+ sunscreen as needed. Longitudinal analysis of study data revealed statistically significant improvement in photodamage, dryness/flaking, dyschromia, and global appearance at eight weeks. All study products were well-tolerated throughout. Investigators concluded that the alpha hydroxy acid retinoid conjugate is a safe and effective topical therapy for moderate-to-severe photodamage, warranting further study, (clinicaltrials.gov, NCT02422836, https://clinicaltrials.gov/ct2/show/NCT02422836?term=NCT02422836).
authors.affiliation: Clinical Professor, Icahn School of Medicine at Mount Sinai, New York, New York;
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Katz
authors.affiliation: US Cosmeceutechs, LLC;
authors.forename: Joseph
authors.initials: J
authors.lastname: Lewis
authors.affiliation: US Cosmeceutechs, LLC;
authors.forename: Laura
authors.initials: L
authors.lastname: McHugh
authors.affiliation: Elizabeth Arden, Inc.
authors.forename: Arthur
authors.initials: A
authors.lastname: Pellegrino
authors.affiliation: US Cosmeceutechs, LLC;
authors.forename: Lavinia
authors.initials: L
authors.lastname: Popescu