title: Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR.
abstract: The hallmarks of allergic bronchial asthma arise from chronic airway inflammation. Thus, elucidating the mechanisms regulating the maintenance of this chronic inflammatory response is key to understanding asthma pathogenesis. To date, it is not clear whether a predominance of proinflammatory factors or a reduced capacity of counterbalancing anti-inflammatory mediators is the pivotal factor predisposing individuals towards asthma development. The IL-1 cytokine family and its receptor systems comprise a variety of proinflammatory cytokines like IL-1β and IL-18 and anti-inflammatory molecules such as the Toll/interleukin-1 receptor 8/single Ig IL-1 receptor (IL-R)-related molecule (Tir8/SIGIRR) and the recently established cytokine IL-37. This article reviews the functions of these IL-1 cytokine family members in the regulation of allergic airway inflammation and asthma as they have been assessed clinically, in vitro and in mouse models.
authors.affiliation: a Division of Asthma Mouse Models, Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North , Member of the German Center for Lung Research , Borstel , Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Lunding
authors.affiliation: a Division of Asthma Mouse Models, Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North , Member of the German Center for Lung Research , Borstel , Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schröder
authors.affiliation: a Division of Asthma Mouse Models, Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North , Member of the German Center for Lung Research , Borstel , Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Wegmann
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology*; D020382:Interleukin-18 / Q000276:immunology; D017472:Receptors, Interleukin-1 / Q000276:immunology*; D053724:Receptors, Interleukin-18 / Q000276:immunology*; D012130:Respiratory Hypersensitivity / Q000276:immunology*
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D020382:Interleukin-18; D017472:Receptors, Interleukin-1; D053724:Receptors, Interleukin-18; C508587:IL37 protein, human; C546891:SIGIRR protein, human
keywords: IL-18Rα; IL-37; TH2 cells; Tir8/SIGIRR; asthma; caspase-1; chronic inflammation; inflammasome; regulation