title: α-Glucosidase Inhibitors from the Fungus Aspergillus terreus 3.05358.
abstract: One new diketopiperazine alkaloid amauromine B (1), along with three known meroterpenoids, austalide B (2), austalides N and O (3 and 4), and two known steroids (5 and 6), was isolated and identified from the culture broth of the fungus Aspergillus terreus 3.05358. Their structures were elucidated by extensive spectroscopic techniques, including 2D-NMR and MS analysis, the absolute configuration of 1 was unambiguously established by single crystal X-ray diffraction analysis. All the isolates were evaluated for their inhibitory effects on α-glucosidase. Amauromine B (1) and austalide N (3) exhibited more potent α-glucosidase inhibitory activities than the positive control acarbose.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone: +86-571-88871075; fax: +86-571-88320913).
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Shan
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone: +86-571-88871075; fax: +86-571-88320913).
authors.forename: Zhao-Ying
authors.initials: ZY
authors.lastname: Wu
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone: +86-571-88871075; fax: +86-571-88320913).
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Pang
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone: +86-571-88871075; fax: +86-571-88320913).
authors.forename: Lie-Feng
authors.initials: LF
authors.lastname: Ma
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone: +86-571-88871075; fax: +86-571-88320913).
authors.forename: You-Min
authors.initials: YM
authors.lastname: Ying
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone: +86-571-88871075; fax: +86-571-88320913). zjnpr@zjut.edu.cn.
authors.forename: Zha-Jun
authors.initials: ZJ
authors.lastname: Zhan
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D000520:alpha-Glucosidases
keywords: Amauromine B; Aspergillus terreus; Austalides; α-Glucosidase inhibitor