title: Tissue Distribution and Whole Body Burden of the Chlorinated Polyfluoroalkyl Ether Sulfonic Acid F-53B in Crucian Carp (Carassius carassius): Evidence for a Highly Bioaccumulative Contaminant of Emerging Concern.
abstract: Following the global actions to phase out perfluoroctanesulfonic acid (PFOS) a large number of alternative per- and polyfluoroalkyl substances, with poorly defined hazard properties, are being used in increasing quantities. Here, we report on the first detection of the chlorinated polyfluoroalkyl ether sulfonic acid F-53B in biological samples and determine the tissue distribution and whole body bioaccumulation factors (BAFwhole body) in crucian carp (Carassius carassius). Analysis of fish samples from Xiaoqing River (XR) and Tangxun Lake (TL) demonstrated a similar level of F-53B contamination with median concentrations in blood of 41.9 and 20.9 ng/g, respectively. Tissue/blood ratios showed that distribution of F-53B primarily occurs to the kidney (TL: 0.48, XR: 0.54), gonad (TL: 0.36, XR: 0.54), liver (TL: 0.38, XR: 0.53), and heart (TL: 0.47, XR: 0.47). Median Log BAFwhole body values for F-53B (XR: 4.124, TL: 4.322) exceeded regulatory bioaccumulation criterion and were significantly higher than those of PFOS in the same data sets (XR: 3.430, TL: 3.279). On the basis of its apparent omnipresence and strong bioaccumulation propensity, it is hypothesized that F-53B could explain a significant fraction of previously unidentified organofluorine in biological samples from China, and regulatory actions for this compound are encouraged.
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences , Beijing 100085, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University , Stockholm SE 106 91, Sweden.
authors.forename: Robin
authors.initials: R
authors.lastname: Vestergren
authors.affiliation: Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University , Wuhan 430056, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences , Beijing 100085, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Song
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences , Beijing 100085, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University , Wuhan 430056, China.|Institute of Environment and Health, Jianghan University , Wuhan 430056, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences , Beijing 100085, China.|Institute of Environment and Health, Jianghan University , Wuhan 430056, China.
authors.forename: Yaqi
authors.initials: Y
authors.lastname: Cai
mesh_terms: D000476:Alkanesulfonates / Q000493:pharmacokinetics*; D000818:Animals; D001822:Body Burden; D002347:Carps / Q000378:metabolism*; D002681:China; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D060106:Lakes / Q000032:analysis; D008297:Male; D045483:Rivers / Q000737:chemistry; D053719:Tandem Mass Spectrometry / Q000379:methods; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: C588014:2-((6-chloro-1,1,2,2,3,3,4,4,5,5,6,6-dodecafluorohexyl)oxy)-1,1,2,2-tetrafluoroethanesulfonic acid; D000476:Alkanesulfonates; D014874:Water Pollutants, Chemical