title: Facile microwave-assisted synthesis of benzimidazole scaffolds via Ugi-type three-component condensation (3CC) reactions.
abstract: Two series of fused benzimidazoles were synthesized via a facile, one-pot procedure under microwave irradiation. This procedure generated the desired products in high yields and could provide a useful synthetic platform with potential applications in medicinal chemistry.
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China.|Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Gui-Ting
authors.initials: GT
authors.lastname: Song
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Xu
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China.
authors.forename: Dian-Yong
authors.initials: DY
authors.lastname: Tang
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China.
authors.forename: Shi-Qiang
authors.initials: SQ
authors.lastname: Li
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Xie
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China.
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Zhong
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Yang
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China. hxxzj2282@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China. 18883138277@163.com.
authors.forename: Zhong-Zhu
authors.initials: ZZ
authors.lastname: Chen
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003486:Cyanides / Q000737:chemistry; D008872:Microwaves; D011725:Pyridines / Q000737:chemistry
chemical_list: D001562:Benzimidazoles; D003486:Cyanides; D011725:Pyridines; C031000:benzimidazole; C023666:pyridine
keywords: Benzimidazole; Cyclization; Groebke–Blackburn reaction; Microwave irradiation; Multicomponent reactions (MCRs); Three-component condensation (3-CC)