title: SUVpeak Performance in Lung Cancer: Comparison to Average SUV from the 40 Hottest Voxels.
abstract: The performance of an average SUV over a 1-mL-volume sphere within an (18)F-FDG-positive lesion resulting in the highest possible value (SUVpeakW) was compared with that of an average SUV computed from the 40 hottest voxels, irrespective of their location within the lesion (SUVmax-40).
  
  
  METHODS
  Dynamic PET performed in 20 lung cancer lesions yielded for each SUV metric its mean value, relative measurement error, and repeatability (MEr-R).
  
  
  RESULTS
  SUVpeakW mean value was significantly 9.66% lower than that of SUVmax-40 (P < 0.0001). SUVpeakW and SUVmax-40 MEr-R were significantly lower than the MEr-R of SUVmax (the hottest voxel): 9.35%-13.21% and 8.84%-12.49% versus 13.86%-19.59%, respectively, (95% confidence limit; P < 0.0001). Although being marginal, SUVpeakW MEr-R was not significantly greater than SUVmax-40 MEr-R (P = 0.086).
  
  
  CONCLUSIONS
  SUVmax-40 is more likely to represent the most metabolically active portions of tumors than SUVpeakW, with close variability performance.
authors.affiliation: CHU de Bordeaux, Service de Médecine Nucléaire, Pessac, France Université de Bordeaux 2, Centre de Recherche Cardio-Thoracique, Bordeaux, France INSERM U 1045, Centre de Recherche Cardio-Thoracique, Bordeaux, France; and elaffon@u-bordeaux2.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Laffon
authors.affiliation: Division of Nuclear Medicine, Department of Medical Radiology, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Irene A
authors.initials: IA
authors.lastname: Burger
authors.affiliation: CHU de Bordeaux, Service de Médecine Nucléaire, Pessac, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Lamare
authors.affiliation: CHU de Bordeaux, Service de Médecine Nucléaire, Pessac, France.
authors.forename: Henri
authors.initials: H
authors.lastname: de Clermont
authors.affiliation: Université de Bordeaux 2, Centre de Recherche Cardio-Thoracique, Bordeaux, France INSERM U 1045, Centre de Recherche Cardio-Thoracique, Bordeaux, France; and.
authors.forename: Roger
authors.initials: R
authors.lastname: Marthan
mesh_terms: D000328:Adult; D000368:Aged; D001692:Biological Transport; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG PET; PERCIST criteria; SUV repeatability; oncology; treatment monitoring