title: Chemotherapy in pregnancy.
abstract: Cancer diagnosed during pregnancy is uncommon, complicating between 0.02% and 0.1% of all pregnancies. Nonetheless, due to increasing age of childbearing, the incidence of cancer during pregnancy is likely to increase due to higher incidence of several age-dependent malignancies. The most common malignancies include breast cancer, cervical cancer, malignant melanoma and lymphoma. One of the key challenges in the management of cancer in pregnancy is treating the women with standard chemotherapy regimen, without compromising the safety of the developing foetus. Exposure of chemotherapy in the first trimester is associated with an increased risk of major birth defects, whereas use in the second and third trimesters is associated with intrauterine growth restriction, low birthweight and stillbirth. In this article, we review available data regarding the use of chemotherapeutic agents in pregnancy, and we summarise the neonatal outcomes, including malformations, perinatal complications and long-term follow-up. In addition, the management plan during pregnancy is also discussed.
authors.affiliation: Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong. Electronic address: ngusiewf@hku.hk.
authors.forename: Siew-Fei
authors.initials: SF
authors.lastname: Ngu
authors.affiliation: Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong. Electronic address: hysngan@hku.hk.
authors.forename: Hextan Y S
authors.initials: HY
authors.lastname: Ngan
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001942:Breast Feeding; D005260:Female; D005865:Gestational Age; D006801:Humans; D010347:Patient Care Planning; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011264:Pregnancy Trimesters; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology*; D064793:Teratogenesis
chemical_list: D000970:Antineoplastic Agents
keywords: cancer; chemotherapy; malformation; pregnancy