title: The management of head and neck tumors with high technology radiation therapy.
abstract: Squamous cell carcinoma is responsible for 90% of the head and neck cancers affecting over 600,000 people worldwide. Radiation therapy, surgery and chemotherapy are the most important treatment modalities in head and neck squamous cell carcinoma. The aim of this review is to summarize the recent innovations in head and neck radiation therapy, which intends to appreciate the cutting-edge intensity-modulated radiation therapy strategies to mitigate long-term toxicities and evaluate promising technologies in the field as adaptive treatment, dose painting and proton therapy.
authors.affiliation: a Service of Radiation Oncology , Hospital Israelita Albert Einstein and Instituto de Radiologia (INRAD) - Faculdade de Medicina da Universidade de São Paulo (FMUSP) , São Paulo , Brazil.
authors.forename: Lucas Castro
authors.initials: LC
authors.lastname: Mendez
authors.affiliation: b Department of Radiation Oncology , Hospital Sírio-Libanes , São Paulo , Brazil.|c Service of Radiotherapy , Instituto de Radiologia (INRAD) - Faculdade de Medicina da Universidade de São Paulo (University of São Paulo - FMUSP) , São Paulo , Brazil.
authors.forename: Fabio Ynoe
authors.initials: FY
authors.lastname: Moraes
authors.affiliation: d Department of Radiation Oncology , Sunnybrook Odette Cancer Centre - University of Toronto , Toronto , Canada.
authors.forename: Ian
authors.initials: I
authors.lastname: Poon
authors.forename: Gustavo Nader
authors.initials: GN
authors.lastname: Marta
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D061766:Proton Therapy / Q000379:methods; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000517:prevention & control; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods*
keywords: Head and neck cancer; quality of life; radiation therapy; toxicity; treatment