title: TRENDS IN GROWTH HORMONE STIMULATION TESTING AND GROWTH HORMONE DOSING IN ADULT GROWTH HORMONE DEFICIENCY PATIENTS: RESULTS FROM THE ANSWER PROGRAM.
abstract: OBJECTIVE
  Adult growth hormone deficiency (AGHD) results in physiologic impairments that may reduce quality of life and negatively impact body composition. AGHD can be treated with recombinant human growth hormone (GH). This study analyzes AGHD patients enrolled in the American Norditropin(®)
  
  
  METHODS
  Web-Enabled-Research (ANSWER) Program/NovoNet, a U.S. observational noninterventional study of patients treated with Norditropin(®) (somatropin [recombinant DNA origin] injection) at the discretion of their physicians.
  
  
  METHODS
  Data were evaluated for GH stimulation test (GHST) usage and Norditropin(®) doses over 4 years.
  
  
  RESULTS
  Adults (N = 468) with isolated GHD (IGHD) or multiple pituitary hormone deficiency (MPHD) were evaluated. The most commonly used GHSTs were arginine + L-dopa (27%; mostly a single center) and glucagon (25%; most frequent test after 2009). The percent of patients meeting recommended test-specific cut points varied from 32 to 100%, depending on the GHST used. Mean baseline GH doses were higher for MPHD patients and for younger patients in both IGHD and MPHD groups.
  
  
  CONCLUSIONS
  MPHD was more common than IGHD. Mean GH doses were higher in younger patients, consistent with a transition from higher pediatric to lower adult dosing. Over time, glucagon became the most popular GHST. The use, in some patients, of other GHSTs with cut points, as well as starting doses not consistent with current recommendations, highlights the need for continued education regarding treatment guidelines for AGHD.
authors.forename: Murray B
authors.initials: MB
authors.lastname: Gordon
authors.forename: Richard A
authors.initials: RA
authors.lastname: Levy
authors.forename: Robert
authors.initials: R
authors.lastname: Gut
authors.forename: John
authors.initials: J
authors.lastname: Germak
mesh_terms: D000328:Adult; D001120:Arginine; D054796:Drug Dosage Calculations; D005260:Female; D005934:Glucagon; D020249:Hormone Replacement Therapy / Q000379:methods; D019382:Human Growth Hormone / Q000032:analysis* / Q000097:blood / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007018:Hypopituitarism / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D007980:Levodopa; D008297:Male; D008875:Middle Aged; D010901:Pituitary Function Tests / Q000379:methods* / Q000639:trends*; D011364:Professional Practice / Q000639:trends
chemical_list: D019382:Human Growth Hormone; D007980:Levodopa; D005934:Glucagon; D001120:Arginine