title: [The Effect of Tadalafil on Sexual Function, Urinary Function and Health-Related Quality of Life in Patients Treated with Brachytherapy].
abstract: We compared sexual function by the expanded prostate cancer index composite (sexual domains of EPIC), health-related quality of life (SF-8), and International Prostate Symptom Score (I-PSS) inpatients using tadalafil after prostate brachytherapy (PB). Forty-five patients who underwent PB between April 2011 and January 2014 were included in this study. Patients were divided into the tadalafil (20 mg,once/week or once/two weeks) treated and non-treated (NT) groups. Sexual function was assessed prior to PB treatment and followed up to 24 weeks after PB. SF-8, sexual domains of EPIC, IPSS and subjective symptoms were assessed pre-PB and at 4, 8, 16, and 24 weeks post-PB. Patients in the tadalafil group achieved higher sexual function scores compared to NT group at all time points. For SF8, the patients in the tadalafil group significantly improved in mental health by the eighth week, and significantly worsened in the NT group (8 w ; p = 0.04). The voiding domains of EPIC score were found to worsen significantly after 4 weeks from PB in both groups, but the score tended to improve over 24 weeks. There was no significant difference between two groups. The I-PSS total score was found to worsen significantly in both groups post-PB, but the tadalafil group had a tendency to worsen less. PB treatment of localized prostate cancer is preferred for the preservation of sexual function. Management of sexual dysfunction with tadalafil after PB does not worsen sexual functions. We concluded that tadalafil might be applicable to mental health care in the treatment of patients with a high interest in sexual function before PB.
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine; National Hospital Organization Osaka Minami Medical Center.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nagai
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Shimizu
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Minami
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Shingo
authors.initials: S
authors.lastname: Toyoda
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Nishimoto
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kikuti
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Saitou
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Taiji
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Tsuji
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nozawa
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshimura
authors.affiliation: The Department of Urology, Kinki University Faculty of Medicine.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Uemura
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011788:Quality of Life; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*; D000068581:Tadalafil / Q000627:therapeutic use*; D014554:Urination / Q000187:drug effects*
chemical_list: D000068581:Tadalafil