title: Invasive fungal infection caused by geotrichum capitatum in patients with acute lymphoblastic leukemia: a case study and literature review.
abstract: Geotrichum capitatum infection has a very low incidence rate with atypical clinical symptoms, making diagnosis difficult, and it has a poor prognosis. The incidence is even more rare in China. This paper reports the first case of infection caused by G. capitatum during bone marrow suppression after chemotherapy in a Chinese patient with acute lymphoblastic leukemia. In addition, it reports a systematic literature review of diagnosis and treatment. The patient with acute lymphoblastic leukemia was confirmed to be infected with G. capitatum, involving lung, liver and skin, through a blood culture test. Caspofungin, amphotericin B loposome, and a combination therapy of amphotericin B liposome and voriconazole were used in succession for treatment. Despite normal body temperature and a slight improvement of clinical symptoms with the combination therapy treatment, the patient died 40 days after chemotherapy due to heart and lung failure.
authors.affiliation: Department of Hematology, People's Liberation Army Center of Hematologic Disorders, Xijing Hospital, Fourth Military Medical University Xi'an 710032, Shaanxi, China.
authors.forename: Guang-Xun
authors.initials: GX
authors.lastname: Gao
authors.affiliation: Department of Hematology, People's Liberation Army Center of Hematologic Disorders, Xijing Hospital, Fourth Military Medical University Xi'an 710032, Shaanxi, China.
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Tang
authors.affiliation: Department of Hematology, People's Liberation Army Center of Hematologic Disorders, Xijing Hospital, Fourth Military Medical University Xi'an 710032, Shaanxi, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Hematology, People's Liberation Army Center of Hematologic Disorders, Xijing Hospital, Fourth Military Medical University Xi'an 710032, Shaanxi, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Xin
authors.affiliation: Department of Hematology, People's Liberation Army Center of Hematologic Disorders, Xijing Hospital, Fourth Military Medical University Xi'an 710032, Shaanxi, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Hematology, People's Liberation Army Center of Hematologic Disorders, Xijing Hospital, Fourth Military Medical University Xi'an 710032, Shaanxi, China.
authors.forename: Xie-Qun
authors.initials: XQ
authors.lastname: Chen
keywords: G. capitatum; Invasive fungal infection; acute lymphoblastic leukemia; immunodeficiency