title: Transducing oxidative stress to death signals in neurons.
abstract: Accumulation of reactive oxygen species (ROS) has been associated with aging and neurodegenerative diseases. Nevertheless, how elevated ROS levels cause neurodegeneration is unclear. In this issue, Wakatsuki et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506102) delineate how oxidative stress is transduced into death signals, leading to neuronal apoptosis and axonal degeneration.
authors.affiliation: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Cao
authors.affiliation: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China fangys@sioc.ac.cn.
authors.forename: Yanshan
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000818:Animals; D008297:Male; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014855:Wallerian Degeneration / Q000378:metabolism*
chemical_list: D044767:Ubiquitin-Protein Ligases