title: Serum Copeptin, Pentraxin 3, Anti-Mullerian Hormone Levels With Echocardiography and Carotid Artery Intima-Media Thickness in Adolescents With Polycystic Ovary Syndrome.
abstract: BACKGROUND
  The aim of the study was to investigate the presence of possible markers in the prediction of polycystic ovary syndrome (PCOS)-related metabolic alterations and cardiovascular events in adolescent PCOS cases and also to investigate the applicability of anti-Mullerian hormone (AMH) levels for the diagnosis of PCOS.
  
  
  METHODS
  In this cross-sectional study, a total of 75 non-obese women (adolescent PCOS group, n = 25; adult PCOS group, n = 25; control group, n = 25) were included. Measurements of copeptin, pentraxin 3 (PTX3), and AMH serum levels were performed.
  
  
  RESULTS
  Serum copeptin, PTX3 and echocardiographic indices were not significantly different in PCOS subjects and they did not have higher common carotid artery intima-media thickness (CIMT) measurement. AMH levels were significantly higher in PCOS patients. There was a positive correlation between AMH and mean ovarian volume (r = 0.58, P < 0.001) and between AMH and total testosterone level (r = 0.63, P < 0.001). In order to predict a threshold value for the diagnosis of PCOS by using AMH, the receiver operating characteristic (ROC) method was used. Area under the curve was 0.820 and cut-off point was 6.66 ng/mL for AMH with a sensitivity of 62% and specificity of 76%.
  
  
  CONCLUSIONS
  Possible markers for PCOS-related metabolic alterations may not present in the adolescent years. Serum AMH may be useful as a diagnostic test for adolescents.
authors.affiliation: Department of Radiology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Deveer
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Ruya
authors.initials: R
authors.lastname: Deveer
authors.affiliation: Department of Cardiology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Basaran
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Ummuhani Ozel
authors.initials: UO
authors.lastname: Turkcu
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Eren
authors.initials: E
authors.lastname: Akbaba
authors.affiliation: Department of Radiology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Nesat
authors.initials: N
authors.lastname: Cullu
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Turhan
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Mert
authors.initials: M
authors.lastname: Kucuk
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Kasap
keywords: AMH; Copeptin; PCOS; PTX3; adolescent