title: Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands).
abstract: Recipients of solid organ transplants (RSOT) have a highly increased risk for developing cutaneous premalignant and malignant lesions, favored by the lifelong immunosuppression. Vascularized composite tissue allografts (VCA) have been introduced recently, and relevant data are sparse. Two patients with skin cancers (one with basal cell carcinoma and one with squamous cell carcinomas) have been so far reported in this patient group. Since 2000 we have been following 9 recipients of VCA (3 face, 6 bilateral hands) for the development of rejection and complications of the immunosuppressive treatment. Among the 9 patients, one face-grafted recipient was diagnosed with nodular-pigmented basal cell carcinoma of her own facial skin 6 years after graft, and one patient with double hand allografts developed disseminated superficial actinic porokeratosis, a potentially premalignant dermatosis, on her skin of the arm and legs. Similar to RSOT, recipients of VCA are prone to develop cutaneous premalignant and malignant lesions. Prevention should be applied through sun-protective measures, regular skin examination, and early treatment of premalignant lesions.
authors.affiliation: Department of Dermatology, Edouard Herriot Hospital Group, 69003 Lyon, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Kanitakis
authors.affiliation: Department of Surgery, University of Cagliari, 09124 Cagliari, Italy.
authors.forename: Palmina
authors.initials: P
authors.lastname: Petruzzo
authors.affiliation: Hand Surgery Department, Clinique du Parc, 69006 Lyon, France.
authors.forename: Aram
authors.initials: A
authors.lastname: Gazarian
authors.affiliation: Department of Maxillofacial Surgery and Stomatology, University Hospital Nord, 80054 Amiens, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Testelin
authors.affiliation: Department of Maxillofacial Surgery and Stomatology, University Hospital Nord, 80054 Amiens, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Devauchelle
authors.affiliation: Department of Transplantation, Edouard Herriot Hospital Group, 69003 Lyon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Badet
authors.affiliation: Department of Transplantation, Edouard Herriot Hospital Group, 69003 Lyon, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dubernard
authors.affiliation: Department of Transplantation, Edouard Herriot Hospital Group, 69003 Lyon, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Morelon