title: No Association of SERPINE1 -675 Polymorphism With Sepsis Susceptibility: A Meta-Analysis.
abstract: The serine protease inhibitor clade E member 1 (SERPINE1) gene has been suggested to exert great influence on the development of sepsis. But there is little overlap in the results of association between SERPINE1 -675 4G/5G polymorphism and sepsis.To get a more precise estimation of this association, we conducted a meta-analysis with a relatively larger sample size including 1806 cases and 2239 controls. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the relationship between -675 4G/5G polymorphism and sepsis susceptibility. Subgroup analyses were conducted based on ethnicity and source of controls.The results showed that there was no association of the SERPINE1 polymorphism and sepsis susceptibility (5G5G vs 4G4G: OR = 0.87, CI = 0.75-1.03; 5G5G+4G5G vs 4G4G: OR = 0.93, CI = 0.84-1.02; 5G5G vs 4G4G+4G5G: OR = 0.96, CI = 0.83-1.11; 5G vs 4G: OR = 0.94, CI = 0.86-1.01; 4G5G vs 4G4G: OR = 0.90, CI = 0.80-1.01). Nor did any subgroup analysis indicate a significant association.In conclusion, -675 4G/5G polymorphism in the SERPINE1 gene may not be associated with the risk of sepsis.
authors.affiliation: From the Third Military Medical University of Chinese People's Liberation Army, Chongqing, China (CS); Department of Dermatology, General Hospital of Beijing Military Region, Beijing, China (CS, ZS, RY); and Department of Burns, General Hospital of Beijing Military Region, Beijing, China (LL).
authors.forename: Chengfang
authors.initials: C
authors.lastname: Shi
authors.forename: Zhifu
authors.initials: Z
authors.lastname: Sui
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Rongya
authors.initials: R
authors.lastname: Yang
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D018805:Sepsis / Q000235:genetics*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human