title: Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells.
abstract: Serum and glucocorticoid kinase 1 (SGK1) has been reported to be up-regulated in non-small cell lung cancer (NSCLC). However, its functions in NSCLC remained unclear. Here, SGK1 was found to be up-regulated in NSCLC samples. Over-expression of SGK1 promoted the growth and migration of NSCLC cells, while down-regulation of SGK1 inhibited the growth, migration and metastasis of NSCLC cells. SGK1 promoted the phosphorylation of GSK3 beta and the accumulation of beta-catenin, up-regulation of the target genes downstream of beta-catenin/TCF signaling, and activating the transcriptional activity of beta-catenin/TCF complex. Collectively, SGK1 might promote the progression of NSCLC through activating beta-catenin/TCF signaling.
authors.affiliation: Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xiaobo
authors.affiliation: Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. Electronic address: linqiang20150420@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Qiang
authors.affiliation: Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Ruan
authors.initials: R
authors.lastname: Zheng
authors.affiliation: Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Jianhua
authors.affiliation: Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhifeng
authors.affiliation: Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Su
authors.initials: S
authors.lastname: Yijiang
authors.affiliation: Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001483:Base Sequence; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics* / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008819:Mice, Nude; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D051820:TCF Transcription Factors / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism; D000099184:Serum-Glucocorticoid Regulated Kinases
chemical_list: D017874:Immediate-Early Proteins; D017346:Protein Serine-Threonine Kinases; D051820:TCF Transcription Factors; D051176:beta Catenin; D000099184:Serum-Glucocorticoid Regulated Kinases; C495270:CTNNB1 protein, human
keywords: Beta-catenin/TCF signaling; Cell growth and migration; NSCLC; SGK1