title: The Role of Echinocandins in Candida Biofilm-Related Vascular Catheter Infections: In Vitro and In Vivo Model Systems.
abstract: Candida biofilm-associated infections of central venous catheters are a challenging therapeutic problem. Recent in vitro and in vivo studies of the structure, formation, pathogenesis, and treatment establish a rationale for new approaches to management of these tenacious infections.
authors.affiliation: Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Ghannoum
authors.affiliation: Infectious Diseases Unit, Third Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration Hospital, Thessaloniki, Greece.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Roilides
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine.
authors.forename: Aspasia
authors.initials: A
authors.lastname: Katragkou
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine.
authors.forename: Vidmantas
authors.initials: V
authors.lastname: Petraitis
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine Department of Pediatrics and Department of Microbiology and Immunology, Weill Cornell Medical Center of Cornell University, New York, New York.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects*; D002175:Candida / Q000187:drug effects* / Q000502:physiology; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D000077336:Caspofungin; D055499:Catheter-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D004195:Disease Models, Animal; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D055666:Lipopeptides / Q000494:pharmacology / Q000627:therapeutic use; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D062666:Vascular Access Devices
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077612:Anidulafungin; D000077336:Caspofungin; D000077551:Micafungin
keywords: anidulafungin; biofilm; caspofungin; echinocandin; micafungin