title: Risk of idiopathic normal pressure hydrocephalus in older inpatients with schizophrenia.
abstract: BACKGROUND
  The mean age of inpatients with schizophrenia has gradually increased in Japan and the risk of fracture in older schizophrenia patients is elevated. One possible cause may be idiopathic normal pressure hydrocephalus (iNPH). The present study aimed to evaluate the prevalence and symptoms of iNPH in older inpatients with schizophrenia.
  
  
  METHODS
  We prospectively examined older inpatients with schizophrenia (N = 21, mean age = 70.5 ± 5.9) in a psychiatric ward. We evaluated iNPH symptoms using the idiopathic Normal-Pressure Hydrocephalus Grading Scale (iNPHGS), Timed Up-and-Go test (TUG), Gait Status Scale (GSS), Mini-Mental State Examination (MMSE), and Neuropsychiatric Inventory (NPI). We also evaluated symptoms of schizophrenia using the Brief Psychiatric Rating Scale (BPRS) and Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). We conducted cerebrospinal fluid (CSF) tap tests for patients with possible-iNPH.
  
  
  RESULTS
  In total, three (14.3%) patients were diagnosed with possible iNPH: age, GS-Gait, GS-Cognition, TUG, 10-meter walking test, GSS, and DIEPSS were significantly increased in these compared to patients without iNPH; however, GS-Urine, MMSE, NPI, and BPRS did not differ significantly. Probable iNPH was diagnosed for two (9.5%) patients because of positive CSF tap tests.
  
  
  CONCLUSIONS
  The prevalence of possible and probable iNPH in older patients with schizophrenia was much higher than that reported for older people without mental illness. Of the symptoms evaluated with the tests employed, only gait disturbances, particularly walking speed, distinguished schizophrenia patients with iNPH. These findings suggest that we should pay more attention to the possibility of iNPH in older patients with schizophrenia.
authors.affiliation: Department of Neuropsychiatry,Molecules and Function,Ehime University Graduate School of Medicine,Shitsukawa,Toon,Ehime 791-0295,Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Yoshino
authors.affiliation: Department of Neuropsychiatry,Molecules and Function,Ehime University Graduate School of Medicine,Shitsukawa,Toon,Ehime 791-0295,Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: Department of Neuropsychiatry,Molecules and Function,Ehime University Graduate School of Medicine,Shitsukawa,Toon,Ehime 791-0295,Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Mori
authors.affiliation: Department of Psychiatry,Futaiwa Hospital,4-160-1,Wakayama,Yawatahama,Ehime 796-8035,Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hirota
authors.affiliation: Department of Neuropsychiatry,Molecules and Function,Ehime University Graduate School of Medicine,Shitsukawa,Toon,Ehime 791-0295,Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Iga
authors.affiliation: Department of Neuropsychiatry,Molecules and Function,Ehime University Graduate School of Medicine,Shitsukawa,Toon,Ehime 791-0295,Japan.
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ueno
mesh_terms: D000368:Aged; D002555:Cerebrospinal Fluid; D005260:Female; D005684:Gait; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000000981:diagnostic imaging*; D007297:Inpatients; D007564:Japan; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000150:complications*; D014057:Tomography, X-Ray Computed
keywords: cerebrospinal fluid tap test; normal pressure hydrocephalus; schizophrenia