title: [SHIFTS IN URINE PROTEIN PROFILE DURING DRY IMMERSION].
abstract: The study was aimed at tracking the proteomic profile of urine in 8 normal volunteers to 5-day dry immersion (DI). The proteome composition was determined by chromatography-mass spectrometry on high-efficient on-line liquid nano chromatograph Agilent 1100; complementary information about the protein spectra was obtained by dint of mass-spectrometer MaXis Impact 4G and hybrid mass-spectrometer LTQ-FT. Functional associations between proteins and biological functions were analyzed using computer system ANDCell (Associative Networks Discovery in Cells). A total of 256 proteins were identified; for 43 proteins difference in the detection rate during the baseline data collection and on DI day 4 exceeded 20%.
authors.lastname: Pastushkova L Kh
authors.forename: A S
authors.initials: AS
authors.lastname: Kononikhin
authors.forename: E S
authors.initials: ES
authors.lastname: Tiys
authors.forename: A M
authors.initials: AM
authors.lastname: Nosovsky
authors.forename: I V
authors.initials: IV
authors.lastname: Dobrokhotov
authors.forename: V A
authors.initials: VA
authors.lastname: Ivanisenko
authors.forename: E N
authors.initials: EN
authors.lastname: Nikolaev
authors.forename: N M
authors.initials: NM
authors.lastname: Novoselova
authors.forename: M A
authors.initials: MA
authors.lastname: Custaud
authors.forename: I M
authors.initials: IM
authors.lastname: Larina
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D058977:Molecular Sequence Annotation; D011507:Proteinuria / Q000378:metabolism*; D020543:Proteome / Q000032:analysis*; D013026:Space Flight; D014893:Weightlessness; D018474:Weightlessness Simulation
chemical_list: D020543:Proteome