title: Alarming rates of virological failure and drug resistance in patients on long-term antiretroviral treatment in routine HIV clinics in Togo.
abstract: Information on efficacy of long-term antiretroviral treatment (ART) exposure in resource-limited countries is still scarce. In 767 patients attending routine HIV centers in Togo and receiving first-line ART for more than four years, 42% had viral load greater than 1000 copies/ml and either were on a completely ineffective ART regime or were with only a single drug active. The actual conditions to ensure lifelong ART in resource-limited countries can have dramatic long-term outcomes.
authors.affiliation: aLaboratoire de Biologie Moléculaire et d'Immunologie (BIOLIM/FSS/UL) bDépartement des sciences fondamentales et biologiques, Faculté des Sciences de la Santé, Université de Lome[Combining Acute Accent], Lomé, Togo cUMI 233, Institut de Recherche pour le Développement (IRD)/INSERM U1175/Université de Montpellier, Montpellier, France dProgramme National de Lutte contre le Sida (PNLS), Lomé, Togo.
authors.forename: Abla A
authors.initials: AA
authors.lastname: Konou
authors.forename: Anoumou Y
authors.initials: AY
authors.lastname: Dagnra
authors.forename: Nicole
authors.initials: N
authors.lastname: Vidal
authors.forename: Mounerou
authors.initials: M
authors.lastname: Salou
authors.forename: Zakillatou
authors.initials: Z
authors.lastname: Adam
authors.forename: Assétina
authors.initials: A
authors.lastname: Singo-Tokofai
authors.forename: Eric
authors.initials: E
authors.lastname: Delaporte
authors.forename: Mireille
authors.initials: M
authors.lastname: Prince-David
authors.forename: Martine
authors.initials: M
authors.lastname: Peeters
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D024882:Drug Resistance, Viral; D005260:Female; D006678:HIV / Q000187:drug effects* / Q000302:isolation & purification; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014037:Togo / Q000453:epidemiology; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents