title: Magnetic Resonance Imaging and Spectroscopy: Application to Experimental Neuro-Oncology.
abstract: The development and use of animal brain tumor models over the past 25 years has helped to advance our understanding of both tumor biology and the effectiveness of new therapeutic approaches. The application of MRI and MRS as noninvasive tools forin vivostudies of intracerebral tumor models provides unique possibilities for furthering our knowledge of brain cancer. This article provides a brief background of traditional techniques used to evaluate growth and treatment efficacy in rodent brain tumor models and overviews the use of MR for quantitating intracerebral tumor growth kinetics and therapeutic response of experimental brain tumors from work conducted in this laboratory. The application of MRI and MRS in rodent brain tumor models for evaluation of novel therapeutic approaches, including gene transfer technology, is discussed. Finally, initial results with diffusion MRI for monitoring the treatment of brain tumors is introduced.
authors.affiliation: Department of Radiology, University of Michigan, School of Medicine, Kresge III Research Building, Room R3315, Box 0553, Ann Arbor, MI 48109-0553 USA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Ross
authors.affiliation: Department of Biological Chemistry, University of Michigan, School of Medicine, Kresge III Research Building, Room R3315, Box 0553, Ann Arbor, MI 48109-0553 USA.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Chenevert
authors.forename: Boklye
authors.initials: B
authors.lastname: Kim
authors.forename: Oded
authors.initials: O
authors.lastname: Ben-Yoseph
keywords: 9L gliosarcoma; glioma; magnetic resonance imaging (MRI); magnetic resonance spectroscopy (MRS); tumor cell kill; tumor growth kinetics