title: Corn Gluten Hydrolysate Affects the Time-Course of Metabolic Changes Through Appetite Control in High-Fat Diet-Induced Obese Rats.
abstract: This study first investigated the effects of corn gluten hydrolysate (CGH) (1.5 g/day) administration for 7 days on appetite-responsive genes in lean Sprague-Dawley (SD) rats. In a second set of experiments, the metabolic changes occurring at multiple time points over 8 weeks in response to CGH (35.33% wt/wt) were observed in high-fat (HF, 60% of energy as fat) diet-fed SD rats. In lean rats, the hypothalamus neuropeptide-Y and proopiomelanocortin mRNA levels of the CGH group were significantly changed in response to CGH administration. In the second part of the study, CGH treatment was found to reduce body weight and perirenal and epididymal fat weight. CGH also prevented an increase in food intake at 2 weeks and lowered plasma leptin and insulin levels in comparison with the HF group. This reduction in the plasma and hepatic lipid levels was followed by improved insulin resistance, and the beneficial metabolic effects of CGH were also partly related to increases in plasma adiponectin levels. The Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR), an index of insulin resistance, was markedly improved in the HF-CGH group compared with the HF group at 6 weeks. According to the microarray results, adipose tissue mRNA expression related to G-protein coupled receptor protein signaling pathway and sensory perception was significantly improved after 8 weeks of CGH administration. In conclusion, the present findings suggest that dietary CGH may be effective for improving hyperglycemia, dyslipidemia and insulin resistance in diet-induced obese rats as well as appetite control in lean rats.
authors.affiliation: Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Hyojung
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 139-743, Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Oran
authors.initials: O
authors.lastname: Kwon
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects*; D004435:Eating / Q000187:drug effects; D005983:Glutens / Q000008:administration & dosage* / Q000494:pharmacology; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood; D009478:Neuropeptide Y / Q000235:genetics; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D003313:Zea mays / Q000737:chemistry*
chemical_list: D007328:Insulin; D020738:Leptin; D009478:Neuropeptide Y; D005983:Glutens
keywords: corn gluten hydrolysates; food intake; leptin; lipid metabolism; obesity