title: Brain natriuretic peptide as a cardiac marker of transient radiotherapy-related damage in left-sided breast cancer patients: A prospective study.
abstract: OBJECTIVE
  Our study evaluated brain natriuretic peptide (BNP) changes over time after adjuvant radiotherapy (RT) in women with left-sided breast cancer investigating its correlation with heart dosimetric parameters.
  
  
  METHODS
  Forty-three patients underwent clinical cardiac examination, electrocardiogram (ECG), echocardiography and BNP measurement before RT (T0) and 1 (T1), 6 (T6) and 12 months (T12) after. After T12 cardiac assessment was performed annually in each patient. Mean values and standard deviation (SD) of BNP, left ventricular ejection fraction (LVEF), V20, V25, V30, V45 and mean dose were calculated. Normalized BNP (BNPn) was calculated as follows: BNPnT1 = BNPT1/BNPT0, BNPnT6 = BNPT6/BNPT0, BNPnT12 = BNPT12/BNPT0. Absolute BNP and BNPn values were used for data analysis.
  
  
  RESULTS
  Median follow-up from the end of RT to the last check-up was 87 months (range 37-120 months). Minimum follow-up was 74 months except for two patients, who died at respectively 37 and 47 months after RT. In all patients LVEF did not change significantly (p = 0.22) after RT. BNP increased significantly (p < 0.001), particularly 1 and 6 months after RT. It slightly decreased after 12 months. BNP did not correlate with V20, V25, V30, V45, mean dose and MHD. All BNPn correlated significantly (p < 0.05) with V20, V25, V30, V45, mean dose and MHD. Four patients had a cardiac event; in the only subject who developed myocardial infarction, V20, V25, V30 and V45 were the highest and BNP increased from T1 and persisted high even at T12.
  
  
  CONCLUSIONS
  Our results confirm that BNP could be a useful minimally invasive marker of early RT related cardiac impairment.
authors.affiliation: Radiation Oncology Section, University of Perugia, Perugia General Hospital, Perugia, Italy. Electronic address: isabella.palumbo@unipg.it.
authors.forename: I
authors.initials: I
authors.lastname: Palumbo
authors.affiliation: Nuclear Medicine and Health Physics Section, University of Perugia, Perugia, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Palumbo
authors.affiliation: Department of Engineering, University of Perugia, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Fravolini
authors.affiliation: Medical Physics Unit, Perugia General Hospital, Perugia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marcantonini
authors.affiliation: Radiation Oncology Division, Perugia General Hospital, Perugia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Perrucci
authors.affiliation: Radiology Division, Perugia General Hospital, Perugia, Italy.
authors.forename: M E
authors.initials: ME
authors.lastname: Latini
authors.affiliation: Radiation Oncology Division, Perugia General Hospital, Perugia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Falcinelli
authors.affiliation: Nuclear Medicine and Health Physics Section, University of Perugia, Perugia, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Sabalich
authors.affiliation: Nuclear Medicine and Health Physics Section, University of Perugia, Perugia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Tranfaglia
authors.affiliation: Internal Medicine Unit, Department of Medicine, University of Perugia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Schillaci
authors.affiliation: Internal Medicine, Angiology and Arteriosclerosis Diseases Unit, Department of Medicine, University of Perugia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Mannarino
authors.affiliation: Radiation Oncology Section, University of Perugia, Perugia General Hospital, Perugia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Aristei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D066126:Cardiotoxicity / Q000097:blood; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000528:radiation effects*; D006801:Humans; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D013318:Stroke Volume / Q000528:radiation effects; D000069584:Unilateral Breast Neoplasms / Q000097:blood / Q000532:radiotherapy*; D016277:Ventricular Function, Left / Q000528:radiation effects
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain
keywords: Brain natriuretic peptide; Cardiac toxicity; Dosimetric parameters; Left breast cancer; Radiotherapy