title: Relationship between pituitary adenoma texture and collagen content revealed by comparative study of MRI and pathology analysis.
abstract: This study is to reveal the relationship between pituitary adenomas and tumor texture by comparing MRI and pathologic results. Preoperative imaging data of 38 cases of pituitary adenoma patients and collagen content of tumor specimens measured by histopathological were analyzed and compared. T2WI and diffusion coefficient assessment were used to reveal the relationship between tumor texture and collagen content. There were 13 cases of soft texture, 17 cases of medium texture and 8 cases of tough texture tumors. Signal intensity of different texture Pituitary adenomas had significant difference on T2WI and ADC map (P < 0.05). The signal intensity ratio of tumor and pons on T2WI had high consistency with tumor texture. Mean collagen contents of soft, medium and tough texture group were 1.51% ± 0.91%, 7.35% ± 2.99% and 18.10% ± 8.24%, respectively. There were significant differences in collagen content of different texture tumors (P < 0.01). The signal intensity of T2WI and ADC images have prediction value for pituitary adenomas texture and T2WI is more reliable.
authors.affiliation: Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University Fuzhou 350025, P. R. China.
authors.forename: Liangfeng
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University Fuzhou 350025, P. R. China.
authors.forename: Shun-An
authors.initials: SA
authors.lastname: Lin
authors.affiliation: Department of Gastroenterology, PLA General Hospital Beijing 100853, P. R. China.
authors.forename: Kaichun
authors.initials: K
authors.lastname: Fan
authors.affiliation: Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University Fuzhou 350025, P. R. China.
authors.forename: Deyong
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University Fuzhou 350025, P. R. China.
authors.forename: Jingfang
authors.initials: J
authors.lastname: Hong
authors.affiliation: Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University Fuzhou 350025, P. R. China.
authors.forename: Shousen
authors.initials: S
authors.lastname: Wang
keywords: ADC; MRI; Pituitary adenoma; T2WI; collagen content; texture