title: Enhanced Periodontal Regeneration by Novel Single Application Sustained Release Nano-Structured Doxycycline Films.
abstract: The use of different drug classes as host modulating agents has been postulated to have significance as an adjunctive remedy curing chronic periodontitis. In this study nano-structured films containing doxycyclin (DOX) were evaluated for such purpose. Nano DOX/chitosan particulate system was prepared using spray drying technique and was then incorporated in PVA-based films. The particles were evaluated for particle size, zeta potential and possible drug/polymer interaction. The films were also tested for in-vitro drug release and clinical efficacy compared with placebo and DOX-loaded films. The formed particles had a zeta potential of + 13.8 mV and particle size of 52.86 nm with a polydispersity of PDI=0.946. No significant drug/polymer interaction was detected by DSC thermal analysis. In-vitro DOX release was sustained for about a week with the nano-structured films showing 23% of the drug released compared with 44% released from DOX films. Clinical efficacy was done on 150 periodontal pockets from patients suffering from moderate chronic periodontitis. Following scaling and root planning they were divided into three groups; group I receiving nano-structured (DOX), group II receiving DOX and group III receiving placebo films. Evaluation was done both clinically and biochemically at base-line, 1 week, 1 month and 2 months following drug application. Clinical findings indicated a significant effect of both nano-structured and DOX films in improving the measured parameters compared with the control and placebo groups.
authors.forename: Maha M
authors.initials: MM
authors.lastname: Mahmoud
authors.affiliation: Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Postal Code 21521, Egypt. wsamy73@yahoo.com.
authors.forename: Wael M
authors.initials: WM
authors.lastname: Samy
mesh_terms: D048271:Chitosan / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D004318:Doxycycline / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use*; D065546:Drug Liberation; D005260:Female; D006801:Humans; D008297:Male; D049329:Nanostructures / Q000008:administration & dosage* / Q000627:therapeutic use; D010316:Particle Size; D010514:Periodontal Pocket / Q000188:drug therapy; D010518:Periodontitis / Q000188:drug therapy*
chemical_list: D003692:Delayed-Action Preparations; D048271:Chitosan; D004318:Doxycycline