title: Vascular effects of flavonoids.
abstract: Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including antiatherogenic, antioxidant, vasodilation, antihypertensive, and antiplatelet activities. These biological properties have been evaluated in several experimental and clinical studies. In addition, extensive reviews have discussed the antiatherogenic effect of these polyphenols. However, limited studies have investigated the potential therapeutic vascular effects of these compounds. This review brings together some recent studies, to establish the different signaling pathways involved in the molecular mechanisms that underlie the vasodilation induced by flavonoids.
authors.forename: Bruno
authors.initials: B
authors.lastname: Almeida Rezende
authors.forename: Aline Carvalho
authors.initials: AC
authors.lastname: Pereira
authors.forename: Steyner F
authors.initials: SF
authors.lastname: Cortes
authors.affiliation: Department of Physiology and Biophysics, Universidade Federal de Minas Gerais. Belo Horizonte ,Brazil. vslemos@icb.ufmg.br.
authors.forename: Virginia Soares
authors.initials: VS
authors.lastname: Lemos
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001808:Blood Vessels / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D002319:Cardiovascular System / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D000959:Antihypertensive Agents; D005419:Flavonoids