title: Dissecting vectorial capacity for mosquito-borne viruses.
abstract: The inter-relationship between mosquitoes and the viruses they transmit is complex. While previously understood barriers to infection and transmission remain valid, additional factors have been uncovered that suggest an 'arms race' between mosquito and virus. These include the mosquito microbiota and interplay between mosquito and viral genetics. Following an infectious blood meal, the mosquito mounts an immune and transcriptional response, leading to altered expression of multiple genes. These complex interactions, specific to vector and virus genotypes, combine with external influences, particularly temperature, to determine vector competence. The mosquito's response to the infecting agent may have consequences in terms of longevity, feeding behavior and/or fecundity. These factors, together with population density and the frequency of host contact determine vectorial capacity.
authors.affiliation: Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, NY, USA. Electronic address: laura.kramer@health.ny.gov.
authors.forename: Laura D
authors.initials: LD
authors.lastname: Kramer
authors.affiliation: Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, NY, USA. Electronic address: alexander.ciota@health.ny.gov.
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Ciota
mesh_terms: D000818:Animals; D009033:Culicidae / Q000382:microbiology / Q000821:virology*; D005822:Genetic Vectors; D054884:Host-Pathogen Interactions; D006801:Humans; D007303:Insect Vectors / Q000382:microbiology / Q000821:virology*; D056265:Microbial Interactions; D064307:Microbiota; D013045:Species Specificity; D014780:Viruses / Q000235:genetics