title: Estrogen receptor α (ESR1) IVS1-397T>C polymorphism lowers risk of fracture.
abstract: BACKGROUND
  Genetic factors are reported to affect fracture incidence. Many groups have explored the correlation of fracture risk with ESR1 IVS1-397T>C. The observed associations, however, are largely inconsistent. This meta-analysis of data from early-released studies was performed in an effort to determine the role of IVS1-397T>C in fracture.
  
  
  METHODS
  Relevant studies were searched through Pubmed, Embase, ScienceDirect, and Wiley Online Library databases. 16 studies meeting all selection criteria were finally identified. We calculated ORs with 95% CIs to assess risk of fracture. Subgroup analyses were performed by subtype, ethnicity and gender.
  
  
  RESULTS
  Data on 2916 cases and 19170 controls were analyzed in the meta-analysis. Overall, we found moderately decreased risk in association with IVS1-397 CC genotype (OR = 0.82, 95% CI = 0.73-0.92; OR = 0.84, 95% CI = 0.76-0.94). The decrease persisted in both hip fracture (OR = 0.82, 95% CI = 0.71-0.94; OR = 0.83, 95% CI = 0.73-0.94) and vertebral fracture (OR = 0.67, 95% CI = 0.50-0.91; OR = 0.78, 95% CI = 0.64-0.97; OR = 0.82, 95% CI = 0.68-0.98) when data were stratified by subtype. We also found a significant trend of decreasing risk in relation to the CC genotype in Caucasian, male and female. All fixed-effects meta-analysis results were homogeneous.
  
  
  CONCLUSIONS
  The meta-analysis demonstrates that risk of fracture seems likely to be decreased due to IVS1-397 CC or CT genotype.
authors.affiliation: The Department of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: The Department of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.affiliation: The Department of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.affiliation: The Department of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Weixu
authors.initials: W
authors.lastname: Li
authors.affiliation: The Department of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Pan
authors.affiliation: The Department of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Wang
keywords: ESR1; fracture; polymorphism