title: [ACTIVITY OF Ca2+,Mg(2+)-ATPase OF SARCOPLASMIC RETICULUM AND CONTRACTION STRENGTH OF THE FROG SKELETAL MUSCLES UNDER THE EFFECT OF ORGANOPHOSPHORUS INSECTICIDES].
abstract: The results of an experimental study of organophosphorus insecticides, including pirimiphosmethyl, diazinon and chlorpyrifos caused a decline of the contraction properties in m. tibialis anterior fiber bundles of Rana temporaria, as well as sarcoplasmic reticulum Ca2+, Mg(2+)-ATPase enzymatic activity reduction are outlined in this paper. Concentration-dependent strengths response diminishing in isolated skeletal muscle fiber bundles as a result of non-cholinergic influence of organophosphorus insecticides were found. A decrease of Ca2+, Mg(2+)-ATPase enzymatic activity in sarcoplasmic reticulum was observed after administration of each insecticide. The most significant inhibition of this enzyme was observed when using chlorpyrifos.
authors.forename: D M
authors.initials: DM
authors.lastname: Nozdrenko
authors.forename: L V
authors.initials: LV
authors.lastname: Korchinska
authors.forename: V M
authors.initials: VM
authors.lastname: Soroca
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004390:Chlorpyrifos / Q000633:toxicity; D003976:Diazinon / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D057075:Enzyme Assays; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D010755:Organophosphates / Q000633:toxicity*; D011896:Rana temporaria; D012519:Sarcoplasmic Reticulum / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D046509:Tissue Culture Techniques
chemical_list: D007306:Insecticides; D010755:Organophosphates; D000255:Adenosine Triphosphate; D017301:Ca(2+) Mg(2+)-ATPase; D004390:Chlorpyrifos; D003976:Diazinon