title: [Tumor angiogenesis: when the Tree of Life turns bad].
abstract: Angiogenesis is a highly controlled multistep process that allows the formation of a harmonious vascular network during embryonic development and in adults. In addition, tumor progression also involves a dedicated blood vessel supply to fuel the tumor mass, pirating physiological molecular and cellular mechanisms. However, tumor angiogenesis is a quite inefficient process, as perfusion is not optimal, vessel integrity is not guaranteed, and vessel network is irrationally organized. While fundamental molecular and cellular mechanisms have been the field of intense investigation, anticancer therapies have evolved with the possibility to target tumor angiogenesis. This review presents the different steps involved in the formation of normal and tumor angiogenesis, and how tumor vasculature abnormalities could contribute to tumorigenesis and conventional therapy failure.
authors.affiliation: Institut Cochin, CNRS UMR8104, Inserm U1016, université Paris Descartes, 22, rue Méchain, 75014 Paris, France.
authors.forename: Lucas
authors.initials: L
authors.lastname: Treps
authors.affiliation: Institut Cochin, CNRS UMR8104, Inserm U1016, université Paris Descartes, 22, rue Méchain, 75014 Paris, France - Centre de recherche en cancérologie Nantes-Angers, CNRS UMR6299, Inserm U892, université de Nantes, 8, quai Moncousu, 44000 Nantes, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Gavard
mesh_terms: D000328:Adult; D000818:Animals; D002459:Cell Fusion; D002465:Cell Movement / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000503:physiopathology / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology