title: [Association of Schizophrenia and its Clinical Implications with the NOS1AP Gene in the Colombian Population].
abstract: BACKGROUND
  The nitric oxide synthase 1 adaptor protein (NOS1AP) gene is possibly implicated in schizophrenia etiopathogenesis.
  
  
  OBJECTIVE
  To determine the association of NOS1AP gene variants with schizophrenia and the relationship of variants with the clinical dimensions of the disorder in the Colombian population.
  
  
  METHODS
  It is a case-control study with 255 subjects per group. Markers within the NOS1AP gene were typified as well as other informative material of genetic origin so as to adjust by population stratification. A factorial analysis of the main components for each item in the Scales for Evaluating Negative Symptoms (SENS) together with the Scales for Evaluating Positive Symptoms (SEPS) to determine clinical dimensions.
  
  
  RESULTS
  Association between the C/C genotype of the rs945713 marker with schizophrenia (OR = 1.79, 95% CI: 1.13 - 2.84) was found. The C/C genotype of the rs945713 was related to higher scores in the "affective flattening and alogia" dimension; and the A/A genotype of the rs4657181 marker was associated to lower scores in the same dimension.
  
  
  CONCLUSIONS
  Significant associations of markers inside the NOS1AP gene with schizophrenia and the "affective flattening and alogia" clinical dimension were found. These results are consistent with previous studies and support the possibility that NOS1AP influences schizophrenia susceptibility. Furthermore, NOS1AP might be a modifier of schizophrenia clinical characteristics.
authors.affiliation: Médica psiquiatra, MSc Epidemiología, PhD Epidemiología, profesora del Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Electronic address: jennygarcia@medicina.udea.edu.co.
authors.forename: Jenny García
authors.initials: JG
authors.lastname: Valencia
authors.affiliation: Bióloga, MSc Genética, Aspirante PhD en Biología con énfasis en Genética, profesora de la Facultad de Medicina, Universidad Pontificia Bolivariana, Medellín, Colombia.
authors.forename: Ana Victoria Valencia
authors.initials: AV
authors.lastname: Duarte
authors.affiliation: Bióloga, estudiante de MSc en Biología con énfasis en Genética, Laboratorio de Genética Molecular, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Ana Lucía Páez
authors.initials: AL
authors.lastname: Vila
authors.affiliation: Bióloga, PhD Genética, Department of Genetics, Evolution and Environment, University College of London.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Kremeyer
authors.affiliation: Médica MSc Salud Pública, PhD Epidemiología, profesora del Departamento de Ciencias Básicas, Facultad Nacional de Salud Pública, Universidad de Antioquia, Medellín, Colombia.
authors.forename: María Patricia Arbeláez
authors.initials: MP
authors.lastname: Montoya
authors.affiliation: Médico, PhD Genética, profesor, University College of London.
authors.forename: Andrés Ruiz
authors.initials: AR
authors.lastname: Linares
authors.affiliation: Médico psiquiatra, MSc Epidemiología, profesor del Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Carlos Alberto Palacio
authors.initials: CA
authors.lastname: Acosta
authors.affiliation: Médico Psiquiatra, MSc Epidemiología, profesor del Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Jorge Ospina
authors.initials: JO
authors.lastname: Duque
authors.affiliation: Biólogo, MSc Bioquímica, profesor, coordinador del Laboratorio de Genética Molecular de la Universidad de Antioquia, Medellín, Colombia.
authors.forename: Gabriel Bedoya
authors.initials: GB
authors.lastname: Berrío
keywords: Esquizofrenia; NOS1AP; Schizophrenia; genetics; genética