title: Predictors of response to renal denervation for resistant arterial hypertension: a single center experience.
abstract: BACKGROUND
  Renal denervation (RDN) has been shown to reduce blood pressure in patients with resistant arterial hypertension (RAH). We aimed to investigate predictors for response to RDN.
  
  
  METHODS
  Patients suffering from RAH underwent RDN after exclusion of secondary causes of hypertension. Ambulatory blood pressure measurement (ABPM) for 24 h was performed at baseline, 6 and 12 months after RDN. Response was defined as a at least 5 mmHg 24 h SBP drop at 6 months. A linear regression model was used to analyze an association between baseline variables and response to RDN.
  
  
  RESULTS
  In total, 45.6% of patients were responders to RDN. In those, there was a significant reduction in ABPM values at 6 and 12 months (12 months: 24 h SBP: -17.2 ± 9.0 mmHg, P < 0.01; 24 h DBP: -9.0 ± 11.6 mmHg, P < 0.01). Per 10 mmHg increase in baseline 24 h SBP, there was a 5.5 mmHg 24 h SBP reduction at 6 months. Per kg/m increase in BMI, 24 h SBP increased by 0.7 mmHg at 6 months. Per increment in antihypertensive drugs used at baseline, there was a 2.7 mmHg 24 h SBP reduction at 6 months.
  
  
  CONCLUSIONS
  Out of a wide range of baseline variables, elevated systolic ABPM values, BMI and the number of antihypertensive drugs used were associated with response. One has to consider the Hawthorne effect, the regression to the mean phenomenon, the actual effect of sympathetic denervation and the interaction of therapy modification when interpreting data from RDN registries without a control arm.
authors.affiliation: a3rd Medical Department, Cardiology and Intensive Care Medicine, Wilhelminen hospital, Vienna b1st Medical Department, Cardiology, Linz General Hospital, Johannes Kepler University Medical School, Linz, Austria.
authors.forename: Miklos
authors.initials: M
authors.lastname: Rohla
authors.forename: Alexander
authors.initials: A
authors.lastname: Nahler
authors.forename: Thomas
authors.initials: T
authors.lastname: Lambert
authors.forename: Christian
authors.initials: C
authors.lastname: Reiter
authors.forename: Verena
authors.initials: V
authors.lastname: Gammer
authors.forename: Michael
authors.initials: M
authors.lastname: Grund
authors.forename: Hermann
authors.initials: H
authors.lastname: Blessberger
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kammler
authors.forename: Alexander
authors.initials: A
authors.lastname: Kypta
authors.forename: Karim
authors.initials: K
authors.lastname: Saleh
authors.forename: Kurt
authors.initials: K
authors.lastname: Huber
authors.forename: Clemens
authors.initials: C
authors.lastname: Steinwender
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Weiss
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000294:innervation*; D013562:Sympathectomy; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents