title: Successful treatment of exertional heat stroke using continuous plasma diafiltration.
abstract: We report a case of severe exertional heat stroke with multiple organ failure successfully treated with continuous plasma diafiltration (CPDF). PDF effectively removed proinflammatory cytokines, and simultaneously, supported liver function. Furthermore, CPDF therapy showed beneficial effects on multiple organ functions. These features suggest that it is a primary treatment option for exertional heat stroke with multiple organ failure. J. Clin. Apheresis 31:490-492, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Inoue
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Sato
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ikawa
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. shimizum@staff.kanazawa-u.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Shimizu
authors.affiliation: Intensive Care Unit, Kanazawa University Hospital, Kanazawa, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Okajima
authors.affiliation: Intensive Care Unit, Kanazawa University Hospital, Kanazawa, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Taniguchi
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yachie
mesh_terms: D000293:Adolescent; D016207:Cytokines / Q000302:isolation & purification; D018883:Heat Stroke / Q000150:complications / Q000628:therapy*; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D017093:Liver Failure / Q000628:therapy; D008297:Male; D009102:Multiple Organ Failure / Q000628:therapy; D010949:Plasma / Q000737:chemistry*; D020127:Recovery of Function
chemical_list: D016207:Cytokines
keywords: heat stroke; liver function; organ failure; plasma diafiltration; proinflammatory cytokines