title: Suppression of fructose-bisphosphate aldolase C expression as a predictor of advanced oral squamous cell carcinoma.
abstract: Glycolysis machinery regulates cancer cell behavior. However, the roles of these glycolysis enzymes in oral squamous cell carcinoma (OSCC) progression remain unknown.
  
  
  
  Fructose-bisphosphate aldolase C (ALDOC) expression in OSCC patients and cell lines was detected using quantitative real-time polymerase chain reaction (PCR). The functions of ALDOC in migration and invasion were determined using gain and loss of function approaches. An orthotopic OSCC animal model was performed to investigate the effects of ALDOC on metastasis and tumorigenesis in vivo.
  
  
  
  ALDOC expression is negatively significantly correlated with clinical outcome and cell migration in vitro and in vivo. ALDOC blocks adenosine triphosphate generation and lactate production, and mutation constructs of Arg42 and Lys146 functionally restore ALDOC-inhibited cell migration and invasion.
  
  
  
  ALDOC functions as an OSCC prognosis marker clinically, and suppresses migration and invasion by its catalytic domain of Arg42 and Lys146. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1075-E1085, 2016.
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.|Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan.
authors.forename: Yue-Ju
authors.initials: YJ
authors.lastname: Li
authors.affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
authors.forename: Tse-Hung
authors.initials: TH
authors.lastname: Huang
authors.affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.
authors.forename: Michael
authors.initials: M
authors.lastname: Hsiao
authors.affiliation: Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Been-Ren
authors.initials: BR
authors.lastname: Lin
authors.affiliation: Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Shih-Jung
authors.initials: SJ
authors.lastname: Cheng
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.|Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan.|Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Cheng-Ning
authors.initials: CN
authors.lastname: Yang
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Lai
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
authors.forename: Tai-Sheng
authors.initials: TS
authors.lastname: Wu
authors.affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
authors.forename: Jia-Ruei
authors.initials: JR
authors.lastname: Fan
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.|Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.|Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Mark Yen-Ping
authors.initials: MY
authors.lastname: Kuo
authors.affiliation: Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan.|Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.|Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Cheng-Chi
authors.initials: CC
authors.lastname: Chang
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000201:enzymology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D006801:Humans; D008297:Male; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D009154:Mutation; D009361:Neoplasm Invasiveness; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D005634:Fructose-Bisphosphate Aldolase
keywords: aldolase C (ALDOC); glycolysis; metabolism; metastasis; oral cancer