title: [The role of oxidative stress in heart failure].
abstract: Oxidative stress plays an important role in the development of heart failure. Reactive oxygen and nitrogen species can be generated in all cell types that can be found in the myocardium. Potential sources of reactive oxygen species are the NADPH oxidases, nitric oxide synthase, lipoxygenases, cyclooxygenase, xanthine oxidase, cytochrome P450 enzymes, and the mitochondrial respiratory chain. The reactive oxygen species mediated damages are implicated in both the vascular system (endothelial dysfunction, atherosclerosis) and the myocardium (remodeling). Oixidative stress causes lipid and protein oixidation as well as single stranded DNA breaks and induces changes in signaling pathways which serve as central transducers of cardiac hypertrophic growth, remodeling and/or ventricular dilatation.
authors.affiliation: I. Belgyógyászati Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Pécs, Ifjúság útja 13., 7624.
authors.forename: Roland
authors.initials: R
authors.lastname: Gál
authors.affiliation: I. Belgyógyászati Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Pécs, Ifjúság útja 13., 7624.
authors.forename: Róbert
authors.initials: R
authors.lastname: Halmosi
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000150:complications / Q000209:etiology / Q000378:metabolism*; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000009:adverse effects* / Q000378:metabolism; D015398:Signal Transduction; D020257:Ventricular Remodeling
chemical_list: D017382:Reactive Oxygen Species
keywords: heart failure; oxidative stress; oxidatív stressz; reactive oxygen species; reaktívoxigén-származékok; remodeling; remodelling; szívelégtelenség