title: Extraversion modulates functional connectivity hubs of resting-state brain networks.
abstract: Personality dimension extraversion describes individual differences in social behaviour and socio-emotional functioning. The intrinsic functional connectivity patterns of the brain are reportedly associated with extraversion. However, whether or not extraversion is associated with functional hubs warrants clarification. Functional hubs are involved in the rapid integration of neural processing, and their dysfunction contributes to the development of neuropsychiatric disorders. In this study, we employed the functional connectivity density (FCD) method for the first time to distinguish the energy-efficient hubs associated with extraversion. The resting-state functional magnetic resonance imaging data of 71 healthy subjects were used in the analysis. Short-range FCD was positively correlated with extraversion in the left cuneus, revealing a link between the local functional activity of this region and extraversion in risk-taking. Long-range FCD was negatively correlated with extraversion in the right superior frontal gyrus and the inferior frontal gyrus. Seed-based resting-state functional connectivity (RSFC) analyses revealed that a decreased long-range FCD in individuals with high extraversion scores showed a low long-range functional connectivity pattern between the medial and dorsolateral prefrontal cortex, middle temporal gyrus, and anterior cingulate cortex. This result suggests that decreased RSFC patterns are responsible for self-esteem, self-evaluation, and inhibitory behaviour system that account for the modulation and shaping of extraversion. Overall, our results emphasize specific brain hubs, and reveal long-range functional connections in relation to extraversion, thereby providing a neurobiological basis of extraversion.
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Pang
authors.affiliation: School of Political Science and Public Administration, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cui
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Xujun
authors.initials: X
authors.lastname: Duan
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Chen
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
authors.affiliation: Center for Information in BioMedicine, Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D005120:Extraversion, Psychological; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D059906:Neuroimaging; D010555:Personality Inventory; D012146:Rest / Q000502:physiology*; D055815:Young Adult
keywords: extraversion; functional connectivity density; functional magnetic resonance imaging; resting-state; resting-state functional connectivity