title: Flexible data integration and curation using a graph-based approach.
abstract: The increasing diversity of data available to the biomedical scientist holds promise for better understanding of diseases and discovery of new treatments for patients. In order to provide a complete picture of a biomedical question, data from many different origins needs to be combined into a unified representation. During this data integration process, inevitable errors and ambiguities present in the initial sources compromise the quality of the resulting data warehouse, and greatly diminish the scientific value of the content. Expensive and time-consuming manual curation is then required to improve the quality of the information. However, it becomes increasingly difficult to dedicate and optimize the resources for data integration projects as available repositories are growing both in size and in number everyday.
  
  
  
  We present a new generic methodology to identify problematic records, causing what we describe as 'data hairball' structures. The approach is graph-based and relies on two metrics traditionally used in social sciences: the graph density and the betweenness centrality. We evaluate and discuss these measures and show their relevance for flexible, optimized and automated data curation and linkage. The methodology focuses on information coherence and correctness to improve the scientific meaningfulness of data integration endeavors, such as knowledge bases and large data warehouses.
  
  
  
  samuel.croset@roche.com
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Roche Innovation Center Basel, F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland.
authors.forename: Samuel
authors.initials: S
authors.lastname: Croset
authors.affiliation: Roche Innovation Center Basel, F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland.
authors.forename: Joachim
authors.initials: J
authors.lastname: Rupp
authors.affiliation: Roche Innovation Center Basel, F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Romacker
mesh_terms: D066289:Data Curation; D006801:Humans; D051188:Knowledge Bases