title: Effect of an isocaloric diet containing fiber-enriched flour on anthropometric and biochemical parameters in healthy non-obese non-diabetic subjects.
abstract: We studied the effect of soluble fiber-enriched products on anthropometric and biochemical variables in 30 healthy non-obese, non-diabetic subjects. This was a randomized, controlled crossover, single-blind, dietary intervention study performed for 8 weeks. Subjects received an isocaloric diet with fiber-enriched products for the first 4 weeks and with regular flour products for the following 4 weeks, or vice versa. Weight, height, measures of fat distribution (waist, hip circumference), glucose, insulin and triglycerides were measured at baseline, after 4 and 8 weeks of intervention. BMI and insulin sensitivity indices were calculated. Weight and BMI decreased in the first period of isocaloric diet in both groups, regardless of the type of flour consumed (weight p<0.01, p<0.001 respectively; BMI p = 0.01, p<0.001 respectively). At the end of the 8 weeks, weight and BMI further decreased in the group consuming the fiber-enriched diet (p<0.01). Insulin resistance, estimated with the Homeostasis Model Assessment index and the Lipid Accumulation Product index, improved in all subjects after the fiber-enriched flour diet (p = 0.03, p = 0.02, respectively). In conclusion, an isocaloric diet supplemented with fiber-enriched products may improve measures of fatness and insulin sensitivity in healthy non-obese non-diabetic subjects. We might hypothesize a similar effect also in subjects with metabolic abnormalities.
authors.affiliation: Diabetology and Metabolic Diseases Unit, I.R.C.C.S. Policlinico San Donato, P.za E. Malan 2, 20096, San Donato Milanese, Milan, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Briganti
authors.affiliation: Diabetology and Metabolic Diseases Unit, I.R.C.C.S. Policlinico San Donato, P.za E. Malan 2, 20096, San Donato Milanese, Milan, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Ermetici
authors.affiliation: Diabetology and Metabolic Diseases Unit, I.R.C.C.S. Policlinico San Donato, P.za E. Malan 2, 20096, San Donato Milanese, Milan, Italy.
authors.forename: Alexis E
authors.initials: AE
authors.lastname: Malavazos
authors.affiliation: Department of Biomedical Sciences for Health, Chair of Clinical Pathology, Università degli Studi di Milano, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Dozio
authors.affiliation: Service of Laboratory Medicine 1-Clinical Pathology, Department of Health Services of Diagnosis and Treatment-Laboratory Medicine, I.R.C.C.S. Policlinico San Donato, P.za E. Malan 2, 20096, San Donato Milanese, Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Giubbilini
authors.affiliation: Service of Laboratory Medicine 1-Clinical Pathology, Department of Health Services of Diagnosis and Treatment-Laboratory Medicine, I.R.C.C.S. Policlinico San Donato, P.za E. Malan 2, 20096, San Donato Milanese, Milan, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Rigolini
authors.affiliation: Diabetology and Metabolic Diseases Unit, I.R.C.C.S. Policlinico San Donato, P.za E. Malan 2, 20096, San Donato Milanese, Milan, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Goggi
authors.affiliation: Diabetology and Metabolic Diseases Unit, I.R.C.C.S. Policlinico San Donato, P.za E. Malan 2, 20096, San Donato Milanese, Milan, Italy.
authors.forename: Lelio
authors.initials: L
authors.lastname: Morricone
authors.affiliation: Department of Biomedical Sciences for Health, Chair of Clinical Pathology, Università degli Studi di Milano, Milan, Italy ; Service of Laboratory Medicine 1-Clinical Pathology, Department of Health Services of Diagnosis and Treatment-Laboratory Medicine, I.R.C.C.S. Policlinico San Donato, P.za E. Malan 2, 20096, San Donato Milanese, Milan, Italy.
authors.forename: Massimiliano Marco
authors.initials: MM
authors.lastname: Corsi Romanelli
keywords: HOMA-IR; fiber-enriched diet; fibers; glycemic index; insulin sensitivity; lipid accumulation product