title: Atopic Dermatitis and Respiratory Allergy: What is the Link.
abstract: Understanding the aetiology and progression of atopic dermatitis and respiratory allergy may elucidate early preventative and management strategies aimed towards reducing the global burden of asthma and allergic disease. In this article, we review the current opinion concerning the link between atopic dermatitis and the subsequent progression of respiratory allergies during childhood and into early adolescence. Advances in machine learning and statistical methodology have facilitated the discovery of more refined definitions of phenotypes for identifying biomarkers. Understanding the role of atopic dermatitis in the development of respiratory allergy may ultimately allow us to determine more effective treatment strategies, thus reducing the patient and economic burden associated with these conditions.
authors.affiliation: Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester, UK ; Centre for Health Informatics, Institute of Population Health, University of Manchester, Manchester, UK.
authors.forename: Danielle C M
authors.initials: DC
authors.lastname: Belgrave
authors.affiliation: Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester, UK.
authors.forename: Angela
authors.initials: A
authors.lastname: Simpson
authors.affiliation: Centre for Health Informatics, Institute of Population Health, University of Manchester, Manchester, UK.
authors.forename: Iain E
authors.initials: IE
authors.lastname: Buchan
authors.affiliation: Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester, UK.
authors.forename: Adnan
authors.initials: A
authors.lastname: Custovic
keywords: Asthma; Atopic dermatitis; Biomarker identification; Dermatology; Respiratory allergy; Review; Statistical machine learning; Stratified and personalised medicine strategies