title: Mortality Prediction Model of Septic Shock Patients Based on Routinely Recorded Data.
abstract: We studied the problem of mortality prediction in two datasets, the first composed of 23 septic shock patients and the second composed of 73 septic subjects selected from the public database MIMIC-II. For each patient we derived hemodynamic variables, laboratory results, and clinical information of the first 48 hours after shock onset and we performed univariate and multivariate analyses to predict mortality in the following 7 days. The results show interesting features that individually identify significant differences between survivors and nonsurvivors and features which gain importance only when considered together with the others in a multivariate regression model. This preliminary study on two small septic shock populations represents a novel contribution towards new personalized models for an integration of multiparameter patient information to improve critical care management of shock patients.
authors.affiliation: Department of Electronics, Information and Bioengineering, University Politecnico of Milan, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Carrara
authors.affiliation: Department of Electronics, Information and Bioengineering, University Politecnico of Milan, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Baselli
authors.affiliation: Department of Electronics, Information and Bioengineering, University Politecnico of Milan, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Ferrario
mesh_terms: D000328:Adult; D019295:Computational Biology; D016208:Databases, Factual; D006439:Hemodynamics; D006801:Humans; D008954:Models, Biological; D015999:Multivariate Analysis; D011379:Prognosis; D012772:Shock, Septic / Q000401:mortality* / Q000503:physiopathology