title: Corynebacteriumspp as causative agents of microbial keratitis.
abstract: To report the clinical and microbiological profile of keratitis caused byCorynebacteriumspp.
  
  
  
  The medical and microbiology records of 22 patients, who had presented at the L V Prasad Eye Institute, Bhubaneswar, between June 2009 and December 2012, and whose corneal scrapings had yielded significant growth ofCorynebacteriumspp, were retrospectively reviewed. A detailed ocular examination was performed before the respective corneal scraping was sent for a microbiological work-up. The data collected from each record included age, gender, predisposing factors (ocular and systemic), clinical presentation, management and outcome of treatment.
  
  
  
  The mean age of the patients was 43.8±24.4 years. Ocular predisposing factor was present in 14 (63.6%) eyes. Surgical intervention was required in 12 (54.5%) patients. In vitro susceptibility (Kirby-Bauer disc diffusion method) results ofCorynebacteriumspp to vancomycin (17/19, 89.5%), cefazolin (16/20, 80%), chloramphenicol (11/20, 55%), ofloxacin (13/19, 68.4%), ciprofloxacin (10/20, 50%) and gatifloxacin (10/19, 52.6%) were variable. Drug resistance (more than one drug) was seen in nine (40.9%)Corynebacteriumisolates, of which, two (22.2%) showed multidrug resistance to three or more classes of antibiotics.
  
  
  
  Corynebacteria can cause severe corneal infection requiring surgical intervention.
authors.affiliation: Cornea and Anterior Segment Service, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.
authors.forename: Sujata
authors.initials: S
authors.lastname: Das
authors.affiliation: Cornea and Anterior Segment Service, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.
authors.forename: Av Subba
authors.initials: AS
authors.lastname: Rao
authors.affiliation: Cornea and Anterior Segment Service, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.
authors.forename: Srikant K
authors.initials: SK
authors.lastname: Sahu
authors.affiliation: Ocular Microbiology Service, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.
authors.forename: Savitri
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000382:microbiology* / Q000473:pathology; D003352:Corynebacterium / Q000302:isolation & purification*; D003354:Corynebacterium Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Cornea