title: Angiomodulatory properties of Rhodiola spp. and other natural antioxidants.
abstract: Disturbances of angiogenesis and oxidative stress can lead to many serious diseases such as cancer, diabetes or ischemic heart disease. Substances neutralizing oxidative stress are known as antioxidants. They can affect angiogenesis process also, and thus, they modulate therapy results. Antioxidants become more and more frequently used in order to maintain homeostasis of the organism and diminish the risk of disease. Herein, we introduce some antioxidant preparations of natural plant origin (Rhodiola, Aloe vera, Resveratrol, Echinacea, Plumbagin) and antioxidant supplements (Padma 28, Reumaherb, Resvega). Analyses of their angiogenic properties, their multidirectional molecular effect on angiogenesis as well as medical application are within the scope of this review. Most of presented preparations down regulate neovascularization. They can be safely administered to patients with abnormally high angiogenesis. Rhodiola modulates, and Echinacea, Aloe vera and Plumbagin inhibit tumour-related angiogenesis in vitro and in vivo (animal models). Resveratrol and Resvega reduce neovascularization in the eye and may be applicable in eye disorders. Padma 28 preparation exhibits angioregulatory activity, decreasing high angiogenesis of cancer cells and increasing physiological angiogenesis, therefore can be used in therapy of patients with various disturbances of angiogenesis. Antioxidant application in the case of angiogenesis-related diseases should take into consideration angiogenic status of the patient.
authors.affiliation: Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Dorota M
authors.initials: DM
authors.lastname: Radomska-Leśniewska
authors.affiliation: Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland ; Second Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Skopiński
authors.affiliation: Department of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Bałan
authors.affiliation: Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Białoszewska
authors.affiliation: Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Jóźwiak
authors.affiliation: Second Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Rokicki
authors.affiliation: Department of Pathology, Medical University of Warsaw, Warsaw, Poland ; Laboratory of Genetic Epidemiology and Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Skopińska-Różewska
authors.affiliation: Laboratory of Genetic Epidemiology and Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Borecka
authors.affiliation: Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Hevelke
keywords: angiomodulatory properties; natural antioxidants plant origin