title: Changes in reproductive physiology of mangrove rivulus Kryptolebias marmoratus following exposure to environmentally relevant doses of ethinyl oestradiol.
abstract: Kryptolebias marmoratus exposed to 4 ng l(-1) of ethinyl oestradiol (EE2) for 30 days experienced significant changes in endogenous 17β-oestradiol (E2) and 11-ketotestosterone (KT) and qualitative changes in gonad morphology. Both hermaphrodites and males showed a significant decrease in E2, whereas only males exhibited a significant decrease in KT. Exposure to EE2 resulted in a decrease in spermatid and spermatocyte density in males and an increase in the number of early stage oocytes in hermaphrodites.
authors.affiliation: Department of Biological Sciences, University of Alabama, 300 Hackberry Lane, Box 870344, Tuscaloosa, AL 35487, U.S.A.
authors.forename: E L
authors.initials: EL
authors.lastname: Johnson
authors.affiliation: Department of BioSciences, Rice University, 6100 Main Street, MS-140, Houston, TX 77005, U.S.A.
authors.forename: K L
authors.initials: KL
authors.lastname: Weinersmith
authors.affiliation: Department of Biological Sciences, University of Alabama, 300 Hackberry Lane, Box 870344, Tuscaloosa, AL 35487, U.S.A.
authors.forename: R L
authors.initials: RL
authors.lastname: Earley
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D004777:Environment; D004958:Estradiol / Q000097:blood; D004997:Ethinyl Estradiol / Q000633:toxicity*; D005260:Female; D006066:Gonads / Q000187:drug effects*; D057850:Hermaphroditic Organisms / Q000502:physiology; D007695:Killifishes / Q000502:physiology*; D008297:Male; D009865:Oocytes / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects*; D013087:Spermatids / Q000187:drug effects; D013090:Spermatocytes / Q000187:drug effects; D013739:Testosterone / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D052244:Endocrine Disruptors; D013739:Testosterone; D004997:Ethinyl Estradiol; D004958:Estradiol; C003600:11-ketotestosterone
keywords: 11-ketotestosterone; 17β-oestradiol; endocrine disruption; fish; gonad morphology; reproduction