title: Autoimmune hepatitis as a presenting manifestation of mixed connective tissue disease in a child. Case report and review of the literature.
abstract: BACKGROUND
  Liver disease is rare in the course of mixed connective tissue disease. Most commonly liver steatosis or elevated liver function tests are reported and only a few cases of mixed connective tissue disease associated with autoimmune hepatitis were described.
  
  
  METHODS
  We report a case of an 11-year old boy with hepatitis on admission to the hospital and symptoms and signs of mixed connective tissue disease. Autoimmune hepatitis has been confirmed by liver biopsy.
  
  
  CONCLUSIONS
  To the best of our knowledge this is the youngest patient with autoimmune hepatitis as a presenting manifestation of mixed connective tissue disease.
authors.affiliation: Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center, Bohoričeva 20, 1000, Ljubljana, Slovenia.
authors.forename: Katarina
authors.initials: K
authors.lastname: Sedej
authors.affiliation: Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center, Bohoričeva 20, 1000, Ljubljana, Slovenia. Natasa.toplak@kclj.si.|Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Natasa.toplak@kclj.si.
authors.forename: Nataša
authors.initials: N
authors.lastname: Toplak
authors.affiliation: Department of Pulmology, University Children's Hospital, University Medical Center, Ljubljana, Slovenia.
authors.forename: Marina
authors.initials: M
authors.lastname: Praprotnik
authors.affiliation: Institute of Pathology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Boštjan
authors.initials: B
authors.lastname: Luzar
authors.affiliation: Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.|Department of Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Ljubljana, Slovenia.
authors.forename: Jernej
authors.initials: J
authors.lastname: Brecelj
authors.affiliation: Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center, Bohoričeva 20, 1000, Ljubljana, Slovenia.|Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Tadej
authors.initials: T
authors.lastname: Avčin
mesh_terms: D001706:Biopsy; D002648:Child; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis*