title: Circulating serum chemerin levels are elevated in lipodystrophy.
abstract: Lipodystrophy (LD) is characterized by loss of adipose tissue, dysregulation of adipokines and severe metabolic complications. Regulation of the insulin resistance-inducing and proinflammatory adipokine chemerin has not been assessed in LD. Therefore, we determined chemerin serum levels in LD, chemerin mRNA expression in insulin-sensitive tissues of LD mice, as well as the impact of metreleptin treatment on circulating chemerin in LD patients.
  
  
  
  Serum chemerin, as well as clinical and biochemical parameters of glucose metabolism, lipid metabolism, and inflammation, was measured in 37 LD patients and 37 age-, gender- and body mass index-matched controls. Furthermore, chemerin mRNA expression was determined in LD mice and controls. Moreover, circulating chemerin was assessed at five different time points in 10 LD patients treated with metreleptin over 1 year.
  
  
  
  Median serum chemerin levels were significantly higher in 37 subjects with LD (234·3 μg/l) as compared to controls (204·0 μg/l) (P = 0·002). Multiple linear regression analysis showed that circulating chemerin was independently and positively associated with glycosylated haemoglobin A1c (HbA1c) and C-reactive protein (CRP). Chemerin mRNA expression was significantly increased 2·5-fold in visceral adipose tissue (VAT) and 5·3-fold in brown adipose tissue (BAT) of LD mice as compared to controls (P < 0·01). Circulating chemerin was not significantly altered by metreleptin treatment.
  
  
  
  Circulating levels of the adipokine chemerin are elevated in LD, as well as independently and positively associated with HbA1c and CRP. Increased chemerin might originate from VAT and BAT.
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Leipzig, Germany.
authors.forename: Konstanze
authors.initials: K
authors.lastname: Miehle
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Leipzig, Germany.|Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany.
authors.forename: Thomas
authors.identifier: 0000-0003-1683-9276
authors.initials: T
authors.lastname: Ebert
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Leipzig, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Kralisch
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Leipzig, Germany.
authors.forename: Annett
authors.initials: A
authors.lastname: Hoffmann
authors.affiliation: Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kratzsch
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Leipzig, Germany.
authors.forename: Haiko
authors.initials: H
authors.lastname: Schlögl
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Leipzig, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.affiliation: Department of Internal Medicine (Endocrinology and Nephrology), University of Leipzig, Leipzig, Germany.|Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood* / Q000235:genetics; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000235:genetics; D050152:Intra-Abdominal Fat / Q000378:metabolism; D020738:Leptin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D008060:Lipodystrophy / Q000097:blood*; D008297:Male; D051379:Mice; D008875:Middle Aged; D010865:Pilot Projects; D012333:RNA, Messenger / Q000097:blood; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein; D018925:Chemokines; D006442:Glycated Hemoglobin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D012333:RNA, Messenger; C478630:RARRES2 protein, human; C415771:metreleptin