title: microRNA expression changes after atrial fibrillation catheter ablation.
abstract: Atrial fibrillation (AF) is most common arrhythmia in general population, with increasing trend in mortality and morbidity. Electrophysiological and structural abnormalities, promoting abnormal impulse formation and propagation, lead to this disease. AF catheter ablation is related to a not small percentage of nonresponder patients. microRNAs (miRs) have been used as AF fibrotic and electrical alterations biomarkers. miRs may differentiate responders patients to ablative approach. Selective miR target therapy, as upregulation by adenovirus transfection and/or miR downregulation by antagomiR, may be used to treat AF patients. Catheter ablation of triggering electrical pulmonary veins activity or fibrotic areas defragmentation may be upgraded by miR therapy to prevent cardiac electrical and fibrotic remodeling after AF ablation.
authors.affiliation: Medical, Surgical, Neurological, Metabolic & Aging Sciences Department, Second University study of Naples, Naples, Italy.|Cardiovascular & Arrhythmias Department, Giovanni Paolo II Research & Care Foundation, Campobasso, Italy.
authors.forename: Celestino
authors.initials: C
authors.lastname: Sardu
authors.affiliation: Cardiovascular & Arrhythmias Department, Giovanni Paolo II Research & Care Foundation, Campobasso, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Santamaria
authors.affiliation: Medical, Surgical, Neurological, Metabolic & Aging Sciences Department, Second University study of Naples, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
authors.affiliation: Medical, Surgical, Neurological, Metabolic & Aging Sciences Department, Second University study of Naples, Naples, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Marfella
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000235:genetics* / Q000378:metabolism / Q000601:surgery*; D006328:Cardiac Catheterization / Q000639:trends*; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism / Q000601:surgery; D017115:Catheter Ablation / Q000639:trends*; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: atrial fibrillation; catheter ablation; microRNA