title: [Natural Outcome of Genital Tract High-risk Human Papillomavirus Infection and Associated Factors among 760 Women].
abstract: OBJECTIVE
  To investigate the natural outcome of genital tract high risk human papillomavirus (HR-HPV) infection and associated factors among women in Xi'an region.
  
  
  METHODS
  Totally 760 women with primary genital tract HR-HPV infection were enrolled and followed up by HPV-DNA genotyping technology. The cervical cytological techniques and/or colposcopy were used when necessary.
  
  
  RESULTS
  Among these subjects,the natural clearance rate of HR-HPV infection was 71.58%,with the median time of 8.10 months. The rate of HPV persistent infection was 22.63%, with the median time of 17.23 months. The rate of progression to cervical intraepithelial neoplasia (CIN)/cervical cancer (CC) was 5.79%, with the median time of 29.34 months. The natural clearance rate (P=0.000), persistent infection rate (P=0.000) and progression rate (P=0.040) in women older than 50 years were statistically difference from other age groups. The persistent infection rate in multiple infections group was significantly lower than that in single infection group (P=0.010), with the median time statistically longer than that in single infection group (P=0.018). The most easily progressive genotypes were HPV-16,HPV-33, HPV-58,HPV-18,HPV-52, and HPV-68, among which HPV-16 was the most common genotype in CIN 3/CC cases, accounting for 85.00%.
  
  
  CONCLUSIONS
  Most of HR-HPV infections are naturally cleared within 2 years, and only a few cases progresses to CIN/CC. Women older than 50 years have a lower natural clearance rate and higher persistent and progressive rates. Multiple infections can affect the persistent infection. HPV-16 is the most common carcinogenic genotype in Xi'an region.
authors.affiliation: Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'anJiaotong University,Xi'an 710061,China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'anJiaotong University,Xi'an 710061,China.
authors.forename: Di
authors.initials: D
authors.lastname: Cao
authors.affiliation: Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'anJiaotong University,Xi'an 710061,China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'anJiaotong University,Xi'an 710061,China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'anJiaotong University,Xi'an 710061,China.
authors.forename: Xu-qin
authors.initials: XQ
authors.lastname: Cui
authors.affiliation: Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xi'anJiaotong University,Xi'an 710061,China.
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Yang
mesh_terms: D003127:Colposcopy; D005260:Female; D005838:Genotype; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections; D060737:Reproductive Tract Infections; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia