title: Platelet-rich fibrin: the benefits.
abstract: Current published data presents confusing results about the effects of platelet-rich fibrin on bone, and there is a need for studies that throw light on its effect. Our main objective therefore was to evaluate (by fractal analysis) osseous regeneration in extraction sockets with and without platelet-rich fibrin in a study with a substantial sample and a reliable technique to calibrate its effects on bone cells. We also assessed the soft tissue response. Thirty-four patients had their bilaterally impacted third molars (68 surgical sites) extracted in this split-mouth study, following which platelet-rich fibrin was placed in one of the sockets. Patients were followed up clinically and radiographically, and a pain score and fractal analysis were used to evaluate healing of soft tissue and bone, respectively. We conclude that platelet-rich fibrin improves healing of both soft and hard tissues. Although osseous healing did not differ significantly between the groups, healing of soft tissue as judged by the pain score was significantly better in the experimental group.
authors.affiliation: Department of Oral & Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India. Electronic address: dryuvikarajkumar@yahoo.com.
authors.forename: Yuvika Raj
authors.initials: YR
authors.lastname: Kumar
authors.affiliation: Department of Oral & Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India. Electronic address: drsm28@gmail.com.
authors.forename: Sujata
authors.initials: S
authors.lastname: Mohanty
authors.affiliation: Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India. Electronic address: dpmaids@gmail.com.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Verma
authors.affiliation: Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India. Electronic address: raunaqreet@gmail.com.
authors.forename: Raunaq Reet
authors.initials: RR
authors.lastname: Kaur
authors.affiliation: Private Dental Practice, New Delhi, India. Electronic address: Priyanka.dr.03@gmail.com.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Bhatia
authors.affiliation: Private Dental Practice, New Delhi, India. Electronic address: drvarunrajkumar@gmail.com.
authors.forename: Varun Raj
authors.initials: VR
authors.lastname: Kumar
authors.affiliation: Department of Oral & Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India. Electronic address: zainabgauri@yahoo.co.in.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Chaudhary
mesh_terms: D001792:Blood Platelets; D001861:Bone Regeneration; D005337:Fibrin; D006801:Humans; D014095:Tooth, Impacted / Q000601:surgery; D014945:Wound Healing
chemical_list: D005337:Fibrin
keywords: Fractal analysis; Osseous regeneration; Platelet rich fibrin (PRF)