title: Radial Versus Femoral Access in Invasively Managed Patients With Acute Coronary Syndrome: A Systematic Review and Meta-analysis.
abstract: BACKGROUND
  Studies in patients with acute coronary syndrome (ACS) undergoing invasive management showed conflicting conclusions regarding the effect of access site on outcomes.
  
  
  OBJECTIVE
  To summarize evidence from recent, high-quality trials that compared clinical outcomes occurring with radial versus femoral access in invasively managed adults with ACS.
  
  
  METHODS
  English-language publications in MEDLINE, EMBASE, and Cochrane databases between January 1990 and August 2015.
  
  
  METHODS
  Randomized trials of radial versus femoral access in invasively managed patients with ACS.
  
  
  METHODS
  Two investigators independently extracted the study data and rated the risk of bias.
  
  
  RESULTS
  Of 17 identified randomized trials, 4 were high-quality multicenter trials that involved a total of 17 133 patients. Pooled data from the 4 trials showed that radial access reduced death (relative risk [RR], 0.73 [95% CI, 0.59 to 0.90]; P = 0.003), major adverse cardiovascular events (RR, 0.86 [CI, 0.75 to 0.98]; P = 0.025), and major bleeding (RR, 0.57 [CI, 0.37 to 0.88]; P = 0.011). Radial procedures lasted slightly longer (standardized mean difference, 0.11 minutes) and had higher risk for access-site crossover (6.3% vs. 1.7%) than did femoral procedures.
  
  
  CONCLUSIONS
  Heterogeneity in outcomes definitions and potential treatment modifiers across studies, including operator experience in radial procedures and concurrent anticoagulant regimens.
  
  
  CONCLUSIONS
  Compared with femoral access, radial access reduces mortality, major adverse cardiovascular events, and major bleeding in patients with ACS undergoing invasive management.
  
  
  BACKGROUND
  None. (PROSPERO registration number: CRD42015022031).
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Andò
authors.forename: Davide
authors.initials: D
authors.lastname: Capodanno
mesh_terms: D054058:Acute Coronary Syndrome / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods*; D005263:Femoral Artery; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D017534:Radial Artery