title: New application of Bacillus strains for optically pure L-lactic acid production: general overview and future prospects.
abstract: Members of the genus Bacillus are considered to be both, among the best studied and most commonly used bacteria as well as the most still unexplored and the most wide-applicable potent bacteria because novel Bacillus strains are continuously being isolated and used in various areas. Production of optically pure l-lactic acid (l-LA), a feedstock for bioplastic synthesis, from renewable resources has recently attracted attention as a valuable application of Bacillus strains. l-LA fermentation by other producers, including lactic acid bacteria and Rhizopus strains (fungi) has already been addressed in several reviews. However, despite the advantages of l-LA fermentation by Bacillus strains, including its high growth rate, utilization of various carbon sources, tolerance to high temperature, and growth in simple nutritional conditions, it has not been reviewed. This review article discusses new findings on LA-producing Bacillus strains and compares them to other producers. The future prospects for LA-producing Bacillus strains are also discussed.
authors.affiliation: a Laboratory of Soil and Environmental Microbiology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology , Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University , Fukuoka , Japan.
authors.forename: Pramod
authors.initials: P
authors.lastname: Poudel
authors.affiliation: a Laboratory of Soil and Environmental Microbiology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology , Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University , Fukuoka , Japan.|b Laboratory of Microbial Environmental Protection, Tropical Microbiology Unit, Center for International Education and Research of Agriculture, Faculty of Agriculture , Kyushu University , Fukuoka , Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Tashiro
authors.affiliation: a Laboratory of Soil and Environmental Microbiology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology , Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University , Fukuoka , Japan.|b Laboratory of Microbial Environmental Protection, Tropical Microbiology Unit, Center for International Education and Research of Agriculture, Faculty of Agriculture , Kyushu University , Fukuoka , Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sakai
mesh_terms: D001407:Bacillus / Q000378:metabolism*; D018533:Biomass; D005285:Fermentation; D019344:Lactic Acid / Q000096:biosynthesis* / Q000737:chemistry*; D060847:Metabolic Engineering; D013237:Stereoisomerism
chemical_list: D019344:Lactic Acid
keywords: biomass; high temperature; lactic acid producing Bacillus strains; metabolic engineering; optical purity