title: Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly.
abstract: OBJECTIVE
  Since vitamin D is an important regulator of muscle function, the effect of vitamin D deficiency on frailty syndrome has been recently studied. This cross-sectional study aimed to determine the association between 25(OH)-vitamin D levels and frailty status in Mexican community-dwelling elderly.
  
  
  METHODS
  Sample of 331 community-dwelling elderly aged 70 or older, a subset of those included in the "Coyoacán cohort" were included. 25(OH)-vitamin D assay and frailty status were measured.
  
  
  RESULTS
  Mean age was 79.3 years and 54.1% were women. Those classified as frail were more likely to have lower Mini-Mental State Examination score (p = 0.015), more disability for instrumental activities of daily living (p < 0.001) and for activities of daily living (p < 0.001). Serum 25(OH)-vitamin D levels were lower in the frail subgroup when compared with the non-frail one (p < 0.001). Multivariate logistic regression analyses showed a significant association between intermediate tertile [odds ratios (OR) = 4.13; 95% confidence intervals (CI) 2.00-8.56] or insufficient tertile (OR = 8.95; 95% CI 2.41-33.30) of vitamin D levels and frailty even after adjusting for potential confounders.
  
  
  CONCLUSIONS
  These results suggest that older adults with low 25(OH)-vitamin D levels are associated with the probability to being frail compared with those with sufficient vitamin D levels.
authors.affiliation: a Instituto Nacional de Geriatría , México, D.F. , Mexico .
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Gutiérrez-Robledo
authors.affiliation: b Departamento de Geriatría , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , México, D.F. , Mexico .|c Centre de recherche Inserm , U897, Bordeaux , France ; Univ Victor Segalen Bordeaux 2, Bordeaux , France .
authors.forename: José Alberto
authors.initials: JA
authors.lastname: Ávila-Funes
authors.affiliation: c Centre de recherche Inserm , U897, Bordeaux , France ; Univ Victor Segalen Bordeaux 2, Bordeaux , France .
authors.forename: Hélène
authors.initials: H
authors.lastname: Amieva
authors.affiliation: c Centre de recherche Inserm , U897, Bordeaux , France ; Univ Victor Segalen Bordeaux 2, Bordeaux , France .
authors.forename: Céline
authors.initials: C
authors.lastname: Meillon
authors.affiliation: d Departamento de Microbiología y Patología , Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Guadalajara , Jalisco , Mexico .|e Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR)-Unidad Sinaloa , Sinaloa , Mexico , and.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Acosta
authors.affiliation: b Departamento de Geriatría , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , México, D.F. , Mexico .
authors.forename: Ana Patricia
authors.initials: AP
authors.lastname: Navarrete-Reyes
authors.affiliation: f Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Guadalajara , Jalisco , Mexico.
authors.forename: Norma
authors.initials: N
authors.lastname: Torres-Carrillo
authors.affiliation: f Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Guadalajara , Jalisco , Mexico.
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Muñoz-Valle
authors.affiliation: a Instituto Nacional de Geriatría , México, D.F. , Mexico .|f Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Guadalajara , Jalisco , Mexico.
authors.forename: Nora Magdalena
authors.initials: NM
authors.lastname: Torres-Carrillo
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data*; D006801:Humans; D057187:Independent Living / Q000706:statistics & numerical data; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Frailty syndrome; older people; vitamin D