title: The rise and fall of felbamate as a treatment for partial epilepsy--aplastic anemia and hepatic failure to blame?
abstract: Felbamate has been approved for refractory partial seizures since the early nineties. Due to safety concerns regarding its use, namely, in aplastic anemia and hepatic failure, felbamate's use has been restricted and a 'Black Box' warning has been inserted. Nonetheless, it is a useful drug in refractory cases of partial epilepsy. There are certain precautions which can prevent and minimize the serious idiosyncratic reactions associated with felbamate, thereby providing an option in refractory cases where no other drug works.
authors.forename: Karan
authors.initials: K
authors.lastname: Thakkar
authors.affiliation: a NMMC , Navi Mumbai , India.
authors.forename: Gauri
authors.initials: G
authors.lastname: Billa
authors.affiliation: b Raptim Research , Mahape, Navi Mumbai 400703 , India.
authors.forename: Jay
authors.initials: J
authors.lastname: Rane
authors.affiliation: c Clinical department, Raptim Research , Mahape, Navi Mumbai , 400703 , India.
authors.forename: Hiren
authors.initials: H
authors.lastname: Chudasama
authors.affiliation: d Medical writing department, Raptim Research , Mahape, Navi Mumbai 400703 , India.
authors.forename: Sailendra
authors.initials: S
authors.lastname: Goswami
authors.affiliation: a NMMC , Navi Mumbai , India.
authors.forename: Rajen
authors.initials: R
authors.lastname: Shah
mesh_terms: D000741:Anemia, Aplastic / Q000209:etiology*; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D000069279:Drug Resistant Epilepsy / Q000188:drug therapy; D004828:Epilepsies, Partial / Q000188:drug therapy*; D000078328:Felbamate; D006801:Humans; D017093:Liver Failure / Q000209:etiology*; D048448:Phenylcarbamates / Q000009:adverse effects* / Q000627:therapeutic use*; D011409:Propylene Glycols / Q000009:adverse effects* / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D000078328:Felbamate
keywords: Lennox-Gastaut syndrome; N-acetyl cysteine; glutathione; partial seizure