title: The role of lncRNAs in hepatocellular carcinoma: opportunities as novel targets for pharmacological intervention.
abstract: Long non-coding RNA (lncRNA) is commonly defined as an RNA with a length of greater than 200 nucleotides, frequently up to 100 kb. Numerous studies have shown that dysregulation of lncRNAs may directly relate to a number of human diseases, particularly in oncology where lncRNAs appear to play an important role. LncRNAs may also play a potentially novel and critical role in the development and progression of hepatocellular carcinoma (HCC). This article discusses lncRNAs as a new possibility for diagnostic and therapeutic approaches for HCC. The authors introduce the relationship between some lncRNAs and HCC, including carcinogenesis, development, metastasis and prognosis. In addition, the authors suggest that the discovery of lncRNAs may encourage the discovery and development of new therapeutic modalities for HCC and that their regulation may be a promising potential treatment for HCC. Clinical studies are required to determine the therapeutic effect of regulating lncRNA in humans with HCC.
authors.affiliation: a Department of Emergency , Zhejiang Provincial People's Hospital , Hangzhou , China.
authors.forename: Hai
authors.initials: H
authors.lastname: Zou
authors.affiliation: b Department of Hepatobiliary Surgery , Lishui Hospital Affiliated to Zhejiang University , Lishui , China.
authors.forename: Chu-Xiao
authors.initials: CX
authors.lastname: Shao
authors.affiliation: b Department of Hepatobiliary Surgery , Lishui Hospital Affiliated to Zhejiang University , Lishui , China.
authors.forename: Qin-Yun
authors.initials: QY
authors.lastname: Zhou
authors.affiliation: c Department of Infection and Liver Diseases, Liver Research Center , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.|d School of the First Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China.
authors.forename: Gui-Qi
authors.initials: GQ
authors.lastname: Zhu
authors.affiliation: c Department of Infection and Liver Diseases, Liver Research Center , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.|e Institute of Hepatology , Wenzhou Medical University , Wenzhou , China.
authors.forename: Ke-Qing
authors.initials: KQ
authors.lastname: Shi
authors.affiliation: f Global Medicines Development , AstraZeneca R&D , Alderley Park , UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Braddock
authors.affiliation: g Department of Hepatobiliary Surgery , Zhejiang Provincial People's Hospital , Hangzhou , China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Huang
authors.affiliation: c Department of Infection and Liver Diseases, Liver Research Center , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.|e Institute of Hepatology , Wenzhou Medical University , Wenzhou , China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Zheng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D015195:Drug Design; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: Long non-coding RNAs; hepatocellular carcinoma; mechanism; targets; tumorigenesis