title: Fenofibrate-induced massive regression of mutiple inflammatory hepatocellular adenoma.
abstract: Inflammatory hepatocellular adenomas (IHCA), which accounts for 40% to 50% of all hepatocellular adenomas are characterized by the activation of the IL6/JAK/STAT pathway. We herein report the case of a 52-year-old woman presenting with severe multiple typical IHCA that regressed dramatically on treatment with fenofibrate, a PPAR agonist known to prevent IL6-induced inflammation experimentally and in humans. Further similar observations are needed to ascertain the potential benefit of this therapeutic approach for large or unresectable IHCA.
authors.affiliation: Service d'hépatologie, hôpital Saint-Antoine, AP-HP, Paris, France. Electronic address: raoul.poupon@gmail.com.
authors.forename: Raoul
authors.initials: R
authors.lastname: Poupon
authors.affiliation: Service d'anatomie et cytologie pathologiques, hôpital Beaujon, AP-HP, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Cazals-Hatem
authors.affiliation: Service de radiologie, hôpital Saint-Antoine, AP-HP, Paris, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Arrivé
mesh_terms: D018248:Adenoma, Liver Cell / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D011345:Fenofibrate / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D011345:Fenofibrate