title: First Experience of Ultrasound-guided Percutaneous Ablation for Recurrent Hepatoblastoma after Liver Resection in Children.
abstract: This study aimed to summarize the first experience with ultrasound-guided percutaneous ablation treatment (PAT) for recurrent hepatoblastoma (HB) after liver resection in children. From August 2013 to October 2014, PAT was used to treat 5 children with a total of 8 recurrent HB (mean size, 1.4 ± 0.8 cm; size range, 0.7-3.1 cm), including 4 patients with 7 tumors in the liver and 1 patient with 1 tumor in the lung. Technical success was achieved in all patients (5/5, 100%). The complete ablation rate after the first ablation session was 80% (4/5) on a patient-by-patient basis and 87.5% (7/8) on a tumor-by-tumor basis. Only 1 patient developed a fever with temperature >39 °C; it lasted 4 days after radiofrequency ablation (RFA) and was resolved by conservative therapy. During the follow-up period, new intrahepatic recurrences after PAT were detected in two patients. One died due to tumor progression 4 months after ablation. The median overall survival time after PAT was 13.8 months. PAT is a safe and promising therapy for children with recurrent HB after liver resection, and further investigation in large-scale randomized clinical trials is required to determine its role in the treatment of this disease.
authors.affiliation: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, Division of Interventional Ultrasound, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
authors.forename: Baoxian
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, Division of Interventional Ultrasound, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
authors.forename: Luyao
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, Division of Interventional Ultrasound, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Pediatric Surgery, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
authors.forename: Zhihai
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, Division of Interventional Ultrasound, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, Division of Interventional Ultrasound, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
authors.forename: Quanyuan
authors.initials: Q
authors.lastname: Shan
authors.affiliation: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, Division of Interventional Ultrasound, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, Division of Interventional Ultrasound, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.|Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Kuang
authors.affiliation: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, Division of Interventional Ultrasound, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xie
mesh_terms: D017115:Catheter Ablation / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D018197:Hepatoblastoma / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D008297:Male; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D019233:Retreatment; D012189:Retrospective Studies; D025321:Surgery, Computer-Assisted; D016896:Treatment Outcome; D047368:Tumor Burden; D014463:Ultrasonography