title: Acute dystonic reaction due to dexketoprofen trometamol.
abstract: Dexketoprofentrometamol (DKP), is a tromethamine salt of the water-soluble S-enantiomer of ketoprofen. As with all other non-steroidal anti-inflammatory agents, the most common side effect of DKP is gastric complications. In this paper, we report a case of dystonic reaction after intravenous DKP use. A 24-year-old man was admitted to our hospital after suffering a leg burn from boiling oil. He had no drug hypersensitivity. An intravenous preparation containing the active ingredient DKP was injected for analgesia, after which the patient experienced an involuntary flexion response in both upper extremities. With a suspected diagnosis of dystonia, biperiden lactate 5 mg/ml was administered via the intramuscular route and the contractions abated within 30 seconds of the injection.As non-steroidal anti-inflammatory agents are commonly used and prescribed in emergency departments, it should be kept in mind that an acute dystonic reaction can develop against one of these agents, DKP.
authors.affiliation: Emergency Department, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors.forename: Afsin Emre
authors.initials: AE
authors.lastname: Kayipmaz
authors.affiliation: Emergency Department, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors.forename: Tufan Akin
authors.initials: TA
authors.lastname: Giray
authors.affiliation: Emergency Department, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors.forename: Suleyman Serdar
authors.initials: SS
authors.lastname: Tasci
authors.affiliation: Emergency Department, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors.forename: Suleyman Serdar
authors.initials: SS
authors.lastname: Tasci
authors.affiliation: Emergency Department, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors.forename: Cemil
authors.initials: C
authors.lastname: Kavalci
authors.affiliation: Emergency Department, Faculty of Medicine, Baskent University, Ankara, Turkey.
authors.forename: Ummu Gulsum
authors.initials: UG
authors.lastname: Kocalar
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004421:Dystonia / Q000139:chemically induced*; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D010146:Pain / Q000188:drug therapy*; D014325:Tromethamine / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; C118296:dexketoprofen trometamol
keywords: Acute dystonia, Dexketoprofen, Emergency.