title: Mucosal-dominant pemphigus vulgaris in a captopril-taking woman with angioedema.
abstract: We describe a 39-year-old woman with an apparent captopril-induced, contact mucosal-dominant pemphigus vulgaris and angioedema, who took captopril during a bout of arterial hypertension. This exposure suggests that captopril and pathophysiology of angioedema stimulated the development of pemphigus vulgaris, which was diagnosed using the novel, indirect immunofluorescence BIOCHIP mosaic, with the modification to detect serum IgG4 autoantibodies. We discuss the patient, who experienced a chain of events leading to the active stage of pemphigus vulgaris, and review concepts of pemphigus vulgaris inducible by drugs and pathological immunity.
authors.affiliation: Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Gornowicz-Porowska
authors.affiliation: Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Marian
authors.initials: M
authors.lastname: Dmochowski
authors.affiliation: Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Pietkiewicz
authors.affiliation: Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Bowszyc-Dmochowska
mesh_terms: D000328:Adult; D000799:Angioedema / Q000139:chemically induced* / Q000473:pathology; D000959:Antihypertensive Agents / Q000009:adverse effects*; D002216:Captopril / Q000009:adverse effects*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D009059:Mouth Diseases / Q000139:chemically induced* / Q000473:pathology; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D010392:Pemphigus / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000959:Antihypertensive Agents; D007074:Immunoglobulin G; D002216:Captopril