title: Development of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine.
abstract: The aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradable progesterone containing vaginal tablets based on modified starch copolymers for the estrus synchronization of ewes. Starch-graft-poly(acrylic acid) copolymers (S-g-PAA) were synthesized and characterized. The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrix erosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tablets were investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitro and in vivo progesterone release profiles from the tablets were compared with two commercial products. Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)gc indicated promising results and might be convenient as an alternative product to the commercial products in veterinary medicine.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Istanbul University, 34320 Avcılar, Istanbul, Turkey. Electronic address: mkgok@istanbul.edu.tr.
authors.forename: Mehmet Koray
authors.initials: MK
authors.lastname: Gök
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Istanbul University, 34320 Avcılar, Istanbul, Turkey.
authors.forename: Saadet
authors.initials: S
authors.lastname: Özgümüş
authors.affiliation: Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcılar, Istanbul, Turkey.
authors.forename: Kamber
authors.initials: K
authors.lastname: Demir
authors.affiliation: Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Dicle University, 21280 Campus/Diyarbakir, Turkey.
authors.forename: Ümüt
authors.initials: Ü
authors.lastname: Cirit
authors.affiliation: Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcılar, Istanbul, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Pabuccuoğlu
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Cevher
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey.
authors.forename: Yıldız
authors.initials: Y
authors.lastname: Özsoy
authors.affiliation: Biopharm Aşı İlaç San. ve Tic. Ltd. Şti. Dolayoba cad. Tolga Sok. No: 3, 34896 Pendik, Istanbul, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Bacınoğlu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000268:Adhesiveness; D000818:Animals; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D009092:Mucous Membrane / Q000378:metabolism; D012756:Sheep; D013213:Starch / Q000737:chemistry*; D014621:Vagina / Q000378:metabolism*; D014730:Veterinary Medicine
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; C006903:carbopol 940; D013213:Starch
keywords: Acrylic acid; Estrus synchronization; Mucoadhesion; Progesterone; Starch; Vaginal drug delivery