title: [Intensive hemoperfusion and long-term hemofiltration for treatment of paraquat poisoning: a case report].
abstract: A 20-year-old male patient was admitted in our department 14 h after paraquat poisoning at the dose of about 50 mL. The patient underwent intensive hemoperfusion for 2 h (3 times a day) for 9 consecutive days and received continuous renal replacement therapy (CRRT) in the mode of continuous veno-venous hemofiltration (CVVH) for 10 consecutive days in addition to routine medications. The biochemical indexes were monitored during the therapy. After the treatment, paraquat concentrations in the blood and urine were decreased, and the patient's urine volume (UV) increased, serum creatinine (Cr) level decreased, and the oxygenation index became normal. Dynamic CT scan showed no obvious pulmonary fibrosis. The patient was followed up for 6 months after discharge and no complaint of discomforts was reported. This case suggests that early intensive hemoperfusion and long-term CVVH may help improve the prognosis after paraquat poisoning.
authors.affiliation: 1Department of Intensive Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China; 2Department of Intensive Care Medicine, Guangdong Provincial Hospital of Integrated Traditional and Western Medicine, Foshan 528200, China. E-mail: 58629656@qq.com.
authors.forename: Zhi-Yun
authors.initials: ZY
authors.lastname: Peng
authors.forename: Ping
authors.initials: P
authors.lastname: Chang
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Zhong-Ran
authors.initials: ZR
authors.lastname: Cen
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Zhan-Guo
authors.initials: ZG
authors.lastname: Liu
mesh_terms: D001784:Blood Gas Analysis; D001794:Blood Pressure; D001826:Body Fluids; D006440:Hemofiltration; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D010269:Paraquat / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy*; D011379:Prognosis; D006435:Renal Dialysis; D055815:Young Adult
chemical_list: D010269:Paraquat