title: Protective effect of Esculin in adjuvant-induced arthritic (AIA) rats via attenuating pro-inflammatory cytokines and oxidative stress.
abstract: The present study was intended to exemplify the protective effect of Esculin (ES; 6,7-dihydroxycoumarin-6-o-glucoside) on the adjuvant induced arthritis in adult female Sprague Dawley rats. It has been found that, treatment of ES has significantly improved the body weight of rats accompanied with a reduction of paw volume in comparison to arthritic control. In addition, ES exhibit inhibitory effect on various pro-inflammatory cytokines, for instance, IL-1β and TNF-α. The level of oxidative stress markers, i.e., nitric oxide and peroxide was also found suppressed after treatment. The treatment of ES prevents the tissue injury mediated via oxidative stress via up-regulating the level of endogenous GSH in a dose dependent manner. Thus, it has been corroborated that, ES exerts potent anti-arthritic activity via attenuating pro-inflammatory cytokines and oxidative stress.
authors.affiliation: The Second Affiliated Hospital of Dalian Medical University Department of orthopedics Liaoning China.
authors.forename: L
authors.initials: L
authors.lastname: Zheng
authors.affiliation: The Second Affiliated Hospital of Dalian Medical University Department of orthopedics Liaoning China yangliangyang@126.com.
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.affiliation: The Second Affiliated Hospital of Dalian Medical University Department of orthopedics Liaoning China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: The Second Affiliated Hospital of Dalian Medical University Department of orthopedics Liaoning China.
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.affiliation: Dalian Medical University Graduate School Dalian China.
authors.forename: Y
authors.initials: Y
authors.lastname: Su
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism*; D004929:Esculin / Q000494:pharmacology*; D005260:Female; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha; D004929:Esculin; D009569:Nitric Oxide