title: Chemical Structure Characteristics and Bioactivity of Small Molecule FAK Inhibitors.
abstract: Focal adhesion kinase (FAK) is a non-receptor tryosine kinase that plays a vital role in tumor cell survival, proliferation and migration. It has been shown that inhibiting the activity of FAK may result in impeding tumor cells invasion and growth. There are several small molecule FAK inhibitors which have been developed with outstanding FAK inhibitory activity. And most of the small molecules are nitrogen-containing aromatic compounds. This review describes the chemical structure characteristics and activity of current small molecule FAK inhibitors that aims to serve as a future reference for the development of potential FAK inhibitors.
authors.forename: Fang-Yuan
authors.initials: FY
authors.lastname: Cao
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Jilin University, No.1266 Fujin Road, Changchun, 130021, China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Zhou
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Yang
authors.forename: Feng-Hui
authors.initials: FH
authors.lastname: Mu
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
keywords: Cancer; FAK inhibitors; chemical structure