title: Tin Powder-Promoted One-Pot Construction of α-Methylene-γ-lactams and Spirolactams from Aldehydes or Ketones, Acylhydrazines, and 2-(Bromomethyl)acrylate.
abstract: A concise and efficient method for the synthesis of α-methylene-γ-lactams is developed from multicomponent one-pot reactions of aldehydes or ketones, hydrazides, and ethyl 2-(bromomethyl)acrylate promoted by tin powder. The reaction proceeds smoothly under mild reaction conditions without using any catalyst to give the corresponding products in high yields. α-Methylene-γ-spirolactams can also be prepared from cyclic ketones.
authors.affiliation: College of Chemistry and Chemical Engineering, Northwest Normal University , 967 Anning East Road, Lanzhou 730070, P. R. China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Xu
authors.affiliation: College of Chemistry and Chemical Engineering, Northwest Normal University , 967 Anning East Road, Lanzhou 730070, P. R. China.
authors.forename: Danfeng
authors.initials: D
authors.lastname: Huang
authors.affiliation: College of Chemistry and Chemical Engineering, Northwest Normal University , 967 Anning East Road, Lanzhou 730070, P. R. China.
authors.forename: Ke-Hu
authors.initials: KH
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Northwest Normal University , 967 Anning East Road, Lanzhou 730070, P. R. China.
authors.forename: Junyan
authors.initials: J
authors.lastname: Ma
authors.affiliation: College of Chemistry and Chemical Engineering, Northwest Normal University , 967 Anning East Road, Lanzhou 730070, P. R. China.
authors.forename: Yingpeng
authors.initials: Y
authors.lastname: Su
authors.affiliation: College of Chemistry and Chemical Engineering, Northwest Normal University , 967 Anning East Road, Lanzhou 730070, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Fu
authors.affiliation: College of Chemistry and Chemical Engineering, Northwest Normal University , 967 Anning East Road, Lanzhou 730070, P. R. China.|State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Yulai
authors.initials: Y
authors.lastname: Hu