title: Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed Patients.
abstract: The pathophysiology of depression is related to neurobiological changes that occur in the monoamine system, hypothalamic-pituitary-adrenal axis, neurogenesis system and the neuroimmune system. In recent years, there has been a growing interest in the research of the effects of exercise on brain function, with a special focus on its effects on brain-derived neurotrophic factor (BDNF), cortisol and other biomarkers. Thus, the aim of this study is to present a review investigating the acute and chronic effects of aerobic exercise on BDNF and cortisol levels in individuals with depression. It was not possible to establish an interaction between aerobic exercise and concentration of BDNF and cortisol, which may actually be the result of the divergence of methods, such as type of exercises, duration of the sessions, and prescribed intensity and frequency of sessions.
authors.forename: Murilo Khede
authors.initials: MK
authors.lastname: Lamego
authors.forename: Antonio Marcos
authors.initials: AM
authors.lastname: de Souza Moura
authors.forename: Flávia
authors.initials: F
authors.lastname: Paes
authors.forename: Nuno Barbosa
authors.initials: NB
authors.lastname: Ferreira Rocha
authors.forename: Alberto Souza
authors.initials: AS
authors.lastname: de Sá Filho
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lattari
authors.forename: Ridson
authors.initials: R
authors.lastname: Rimes
authors.forename: João
authors.initials: J
authors.lastname: Manochio
authors.forename: Henning
authors.initials: H
authors.lastname: Budde
authors.forename: Mirko
authors.initials: M
authors.lastname: Wegner
authors.forename: Gioia
authors.initials: G
authors.lastname: Mura
authors.forename: Oscar
authors.initials: O
authors.lastname: Arias-Carrión
authors.affiliation: School of Psychology, Nanjing Normal University, Nanjing, China. ytf0707@126.com.
authors.forename: Ti-Fei
authors.initials: TF
authors.lastname: Yuan
authors.forename: Antonio Egidio
authors.initials: AE
authors.lastname: Nardi
authors.affiliation: Laboratory of Panic and Respiration, Institute of Psychiatry (IPUB) - Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. secm80@gmail.com.
authors.forename: Sergio
authors.initials: S
authors.lastname: Machado
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human; D006854:Hydrocortisone