title: [Factors Associated with Cognitive Decline in a Population Less than 65 Years Old. A Systematic Review].
abstract: BACKGROUND
  Cognitive decline could begin 20 years before the diagnosis of dementia. Besides age, several factors related to medical, socioeconomic, and behavioral and genetic condition may be associated with cognitive decline. The aim of this systematic review was to summarize evidence on the risk and protective factors for cognitive decline in people under 65 years old.
  
  
  METHODS
  A systematic review was conducted using a search strategy in MEDLINE and Embase, including longitudinal studies to analyze the effect of protective or risk factors on cognitive decline in a population under 65 years old.
  
  
  RESULTS
  A total of 22 studies were included in this review. Factors such as diabetes, hyperinsulinemia, overweight or obesity, metabolic syndrome, education, physical activity, cognitive stimulation, marital status and diet, could be related to cognitive decline before 65 years of age.
  
  
  CONCLUSIONS
  Cardiovascular risk factors and lifestyle conditions may be associated with cognitive decline before 65 years of age. However, the quality of the evidence was low.
authors.affiliation: Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Electronic address: agua.dc@gmail.com.
authors.forename: Daniel Camilo
authors.initials: DC
authors.lastname: Aguirre-Acevedo
authors.affiliation: Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Eliana
authors.initials: E
authors.lastname: Henao
authors.affiliation: Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Tirado
authors.affiliation: Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Claudia
authors.initials: C
authors.lastname: Muñoz
authors.affiliation: Facultad de Psicología, Universidad de San Buenaventura, Medellín, Colombia.
authors.forename: Diana
authors.initials: D
authors.lastname: Giraldo Arango
authors.affiliation: Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia; Grupo Académico de Epidemiología Clínica y Departamento de Medicina Interna, Facultad de Medicina, Universidad de Antioquia; Unidad de Investigaciones, Hospital Pablo Tobón Uribe, Medellín, Colombia.
authors.forename: Francisco
authors.initials: F
authors.lastname: Lopera Restrepo
authors.affiliation: Grupo Académico de Epidemiología Clínica y Departamento de Medicina Interna, Facultad de Medicina, Universidad de Antioquia; Unidad de Investigaciones, Hospital Pablo Tobón Uribe, Medellín, Colombia.
authors.forename: Fabián
authors.initials: F
authors.lastname: Jaimes Barragán
keywords: Cognitive decline; Demencia; Dementia; Deterioro cognitivo; Factores de riesgo; Revisión sistemática; Risk factors; Systematic review