title: Using mice to model Obsessive Compulsive Disorder: From genes to circuits.
abstract: Obsessive Compulsive Disorder (OCD) is a severe, chronic, and highly prevalent psychiatric disorder that affects between 1.5% and 3% of people worldwide. Despite its severity, high prevalence, and clear societal cost, current OCD therapies are only partially effective. In order to ultimately develop improved treatments for this severe mental illness, we need further research to gain an improved understanding of the pathophysiology that underlies obsessions and compulsions. Though studies in OCD patients can provide some insight into the disease process, studies in humans are inherently limited in their ability to dissect pathologic processes because of their non-invasive nature. The recent development of strategies for genetic and circuit-specific manipulation in rodent models finally allows us to identify the molecular, cellular, and circuit events that lead to abnormal repetitive behaviors and affect dysregulation relevant to OCD. This review will highlight recent studies in mouse model systems that have used transgenic and optogenetic tools in combination with classic pharmacology and behavioral techniques to advance our understanding of these pathologic processes.
authors.affiliation: Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, United States; Center for Neuroscience Program and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: ahmarise@upmc.edu.
authors.forename: Susanne E
authors.initials: SE
authors.lastname: Ahmari
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D006801:Humans; D008822:Mice, Transgenic; D009771:Obsessive-Compulsive Disorder / Q000235:genetics* / Q000503:physiopathology* / Q000523:psychology
keywords: Obsessive Compulsive Disorder (OCD); animal models; anxiety; basal ganglia; optogenetic; orbitofrontal cortex (OFC)