title: [Drug Abuse Comorbidity in Bipolar Disorder].
abstract: BACKGROUND
  Drug use among patients with bipolar disorder is greater than the one observed in the general population; psychotic episodes are likely to occur after consumption. This has implications in the prevention, etiology, management, and treatment of the disease. Bipolar disorder pathology is likely to have positive response to pharmacological treatment. Therefore, identifying the strategies with better results to be applied in these patients is fundamental for psychiatrists and primary care physicians.
  
  
  OBJECTIVE
  Review literature in order to determine the prevalence and characteristics of drug abuse in patients with bipolar disorder and establish the pharmacological strategies that have produced better results.
  
  
  METHODS
  Literature review.
  
  
  RESULTS
  A great variety of studies demonstrate the relationship between bipolar disorder and drug use disorder. These patients are hospitalized more frequently, have an earlier onset of the disease, and present a larger number of depressive episodes and suicide attempts which affect the course of the disease. The drug with better results in the treatment of these patients is Divalproate. Satisfactory results have been also obtained with other mood stabilizers such as carbamazepine, lamotrigine, and the antipsychotic aripiprazole.
  
  
  CONCLUSIONS
  Substance abuse is present in a large number of patients with bipolar disorder. The Divalproate is the drug that has shown better results in the studies.
authors.affiliation: Psiqu-iatra, profesor de Psiquiatría, doctor (Ph. D.) en Neurociencias, Facultad de Medicina de la Universidad de los Andes, San Cristóbal, Venezuela. Electronic address: oscarmedina61@yahoo.es.
authors.forename: Óscar Medina
authors.initials: ÓM
authors.lastname: Ortiz
keywords: Bipolar disorder; Trastorno bipolar; comorbidity; comorbilidad; consumo de sustancias; drug use