title: Metabolic status and resistin in chronic schizophrenia over a 2-year period with continuous atypical antipsychotics.
abstract: BACKGROUND
  Common adverse effects of atypical antipsychotic treatments for schizophrenia are weight gain and lipid metabolism abnormality. We aimed to identify the signs of metabolic problems with continuous atypical antipsychotic treatment for schizophrenia over a 2-year period.
  
  
  METHODS
  The participants were 68 schizophrenic patients (29 males, 39 females; ages 53.4 ± 13.5 years old). Changes in carbohydrate metabolism and changes in physical characteristics were studied over a 2-year period. In addition, functional single nucleotide polymorphisms in the transcriptional regulatory region of the resistin gene were examined.
  
  
  RESULTS
  We found no changes in the mental state of the participants over a 2-year period. Patients did show a significant decrease in total cholesterol and hemoglobin A1c levels, although physical changes such as body mass index and abdominal girth, were not observed. The amount of resistin may not be associated with mental states and physical parameters.
  
  
  CONCLUSIONS
  We could not find physical factors related to metabolic changes of antipsychotics in this 2-year study. However, several psychological factors, such as health-related thoughts and behaviors, should be studied in the future.
authors.affiliation: Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791-0295, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kawabe
authors.affiliation: Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ochi
authors.affiliation: Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Yoshino
authors.affiliation: Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Mori
authors.affiliation: Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Onuma
authors.affiliation: Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Osawa
authors.affiliation: Horie Hospital, Matsuyama City, Ehime, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hosoda
authors.affiliation: Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan.
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ueno
keywords: antipsychotics; diabetes; metabolic syndrome; resistin; schizophrenia