title: PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine.
abstract: Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org.
authors.affiliation: Medicinal Bioconvergence Research Center, Seoul National University, Seoul 152-742, Republic of Korea.|Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.|Information Center for Bio-pharmacological Network, Seoul National University, Suwon 443-270, Republic of Korea.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.|Information Center for Bio-pharmacological Network, Seoul National University, Suwon 443-270, Republic of Korea.
authors.forename: Kyoung Mii
authors.initials: KM
authors.lastname: Park
authors.affiliation: Medicinal Bioconvergence Research Center, Seoul National University, Seoul 152-742, Republic of Korea.|Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Dong-Jin
authors.initials: DJ
authors.lastname: Han
authors.affiliation: Medicinal Bioconvergence Research Center, Seoul National University, Seoul 152-742, Republic of Korea.|Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Nam Young
authors.initials: NY
authors.lastname: Bang
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Do-Hee
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Hyeongjin
authors.initials: H
authors.lastname: Na
authors.affiliation: Medicinal Bioconvergence Research Center, Seoul National University, Seoul 152-742, Republic of Korea.
authors.forename: Semi
authors.initials: S
authors.lastname: Lim
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Tae Bum
authors.initials: TB
authors.lastname: Kim
authors.affiliation: Medicinal Bioconvergence Research Center, Seoul National University, Seoul 152-742, Republic of Korea.
authors.forename: Dae Gyu
authors.initials: DG
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Yeonseok
authors.initials: Y
authors.lastname: Chung
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Sung
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Surh
authors.affiliation: Medicinal Bioconvergence Research Center, Seoul National University, Seoul 152-742, Republic of Korea.|Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Kim
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.|Information Center for Bio-pharmacological Network, Seoul National University, Suwon 443-270, Republic of Korea.
authors.forename: Byung Woo
authors.initials: BW
authors.lastname: Han
mesh_terms: D003628:Database Management Systems; D008519:Medicine, Traditional; D056910:Republic of Korea; D018511:Systems Integration