title: Recombinant measles AIK-C vaccine strain expressing heterologous virus antigens.
abstract: Further attenuated measles vaccines were developed more than 50 years ago and have been used throughout the world. Recombinant measles vaccine candidates have been developed and express several heterologous virus protective antigens. Immunogenicity and protective actions were confirmed using experimental animals: transgenic mice, cotton rats, and primates. The recent development of measles vaccine-based vectored vaccine candidates has been reviewed and some information on recombinant measles vaccines expressing respiratory syncytial virus proteins has been shown and discussed.
authors.affiliation: Kitasato Institute for Life Sciences, Laboratory of Viral Infection I, Minato-ku, Tokyo 108-8641, Japan. Electronic address: tetsuo-n@lisci.kitasato-u.ac.jp.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nakayama
authors.affiliation: Kitasato Institute for Life Sciences, Laboratory of Viral Infection I, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Akihito
authors.initials: A
authors.lastname: Sawada
authors.affiliation: Kitasato Institute for Life Sciences, Laboratory of Viral Infection I, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yamaji
authors.affiliation: Kitasato Institute for Life Sciences, Laboratory of Viral Infection I, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ito
mesh_terms: D000818:Animals; D000941:Antigens / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D004337:Drug Carriers; D015870:Gene Expression; D008459:Measles virus / Q000235:genetics*; D008822:Mice, Transgenic; D011323:Primates; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D022261:Respiratory Syncytial Virus Vaccines / Q000235:genetics / Q000276:immunology*; D012136:Respiratory Syncytial Viruses / Q000235:genetics / Q000276:immunology*; D016205:Sigmodontinae; D016896:Treatment Outcome; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology
chemical_list: D000941:Antigens; D004337:Drug Carriers; D011994:Recombinant Proteins; D022261:Respiratory Syncytial Virus Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic
keywords: AIK-C measles vaccine; Recombinant virus; Respiratory syncytial virus; Reverse genetics