title: MTOR, PIK3C3, and autophagy: Signaling the beginning from the end.
abstract: A key point in starvation-induced autophagy occurs at the end of the process, where lysosomes are regenerated from autolysosomes through a pathway termed autophagic lysosome reformation (ALR). ALR occurs when autolysosomal MTOR becomes reactivated by amino acids derived from the autophagic delivery of protein cargo. This activation not only turns off autophagosome formation but also leads to reformation of lysosomes, ready for the next round of autophagy, through a series of events involving autolysosomal tubulation. We have now found that MTOR regulates multiple steps of ALR including direct activation of the PIK3C3-UVRAG lipid kinase complex to enable autolysosomal tubules to break away and regenerate lysosomes.
authors.affiliation: a MRC Protein Phosphorylation and Ubiquitylation Unit; College of Life Sciences; University of Dundee ; Dundee , UK.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Munson
authors.affiliation: a MRC Protein Phosphorylation and Ubiquitylation Unit; College of Life Sciences; University of Dundee ; Dundee , UK.
authors.forename: Ian G
authors.initials: IG
authors.lastname: Ganley
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D058546:Class III Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D010588:Phagosomes / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D058546:Class III Phosphatidylinositol 3-Kinases; D058570:TOR Serine-Threonine Kinases
keywords: MTOR; UVRAG; VPS34; autophagic lysosome reformation; lysosome; phosphatidylinositol 3-phosphate; tubulation