title: Effects of Quince syrup on clinical symptoms of children with symptomatic gastroesophageal reflux disease: A double-blind randomized controlled clinical trial.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy of Quince syrup in pediatrics with symptomatic gastroesophageal reflux disease (GERD).
  
  
  METHODS
  Participants (n = 80) were randomly assigned to the Quince group (0.6 cc/kg/day) or the Omeprazole group (1 cc/kg/day). Age specific questionnaires were used to assess the frequency and severity of the GERD symptoms. Mean of cumulative symptom score (CSS) at weeks 4 and 7 were compared with baseline.
  
  
  RESULTS
  The mean CSS value was significantly decreased from baseline in each treatment group without statistically significant differences between them. Although the mean CSS value among infants and young children was slightly decreased in the Quince group at week seven, this value was increased among children aged 5-18 years in both treatment groups without significant differences.
  
  
  CONCLUSIONS
  Despite the effectiveness of Quince syrup in reducing symptoms in all pediatrics age groups, no significant differences were observed in comparison with the control group.
authors.affiliation: Department of Traditional Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: Zohalinm@sums.ac.ir.
authors.forename: Mohammad Ebrahim
authors.initials: ME
authors.lastname: Zohalinezhad
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Hadi
authors.initials: MH
authors.lastname: Imanieh
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Soliman Mohammadi
authors.initials: SM
authors.lastname: Samani
authors.affiliation: Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Abdolali
authors.initials: A
authors.lastname: Mohagheghzadeh
authors.affiliation: Department of Pediatric Gastroenterology, Gastroenterohepatology Research Center of Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Seyed Mohsen
authors.initials: SM
authors.lastname: Dehghani
authors.affiliation: Department of Pediatric Gastroenterology, Gastroenterohepatology Research Center of Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Haghighat
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Salehi
authors.affiliation: Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Pouya
authors.initials: P
authors.lastname: Faridi
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Amin Reza
authors.initials: AR
authors.lastname: Akbarzadeh
mesh_terms: D000293:Adolescent; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009853:Omeprazole / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use*; D027824:Rosaceae / Q000737:chemistry*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D009853:Omeprazole
keywords: Children; Clinical trial; Cydonia oblonga Mill.; Gastroesophageal reflux disease; Omeprazole; Traditional Persian medicine