title: Anticipation of the Impact of Human Papillomavirus on Clinical Decision Making for the Head and Neck Cancer Patient.
abstract: Human papillomavirus (HPV) is the cause of a distinct subset of oropharyngeal cancer rising in incidence in the United States and other developed countries. This increased incidence, combined with the strong effect of tumor HPV status on survival, has had a profound effect on the head and neck cancer discipline. The multidisciplinary field of head and neck cancer is in the midst of re-evaluating evidence-based algorithms for clinical decision making, developed from clinical trials conducted in an era when HPV-negative cancer predominated. This article reviews relationships between tumor HPV status and gender, cancer incidence trends, overall survival, treatment response, racial disparities, tumor staging, risk stratification, survival post disease progression, and clinical trial design.
authors.affiliation: Cancer Control and Prevention Program, The Ohio State University Comprehensive Cancer Center, The Ohio State University, 420 West 12th Avenue, Room 620, Columbus, OH 43210, USA. Electronic address: Maura.gillison@osumc.edu.
authors.forename: Maura L
authors.initials: ML
authors.lastname: Gillison
authors.affiliation: Medical Oncology, Istituto Nazionale dei Tumori, Via G. Venezian, 1, Milano 20133, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Restighini
mesh_terms: D052685:Alphapapillomavirus / Q000145:classification / Q000502:physiology*; D000066491:Clinical Decision-Making; D018450:Disease Progression; D019317:Evidence-Based Medicine; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality / Q000601:surgery; D006801:Humans; D015994:Incidence; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000401:mortality / Q000601:surgery; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D011379:Prognosis; D044469:Racial Groups; D012107:Research Design
keywords: Clinical decision making; Head and neck cancer; Human papillomavirus; Patient; Prognosis; Survival