title: Comparison of Childhood Vitiligo Presenting with or without Associated Halo Nevi.
abstract: BACKGROUND
  Previous studies have characterized differences in vitiligo associated with halo nevi, but the features of vitiligo presenting with halo nevus in children have yet to be fully described.
  
  
  OBJECTIVE
  We sought to provide an epidemiologic and clinical comparison of cases of childhood vitiligo presenting with or without associated halo nevi.
  
  
  METHODS
  This was a retrospective chart review of children diagnosed with vitiligo in an academic pediatric dermatology practice from January 1990 to November 2014. The characteristics of children with vitiligo with or without associated halo nevi were compared.
  
  
  RESULTS
  Halo nevi were identified in 55 (26%) of 208 children with vitiligo. Patients with halo nevi were significantly more likely to be male and develop vitiligo at a later age. Children with vitiligo associated with halo nevi were more likely to present with generalized vitiligo, defined according to the presence of bilateral macules.
  
  
  CONCLUSIONS
  There was no significant association between groups in the percentage of body surface area with vitiligo or family history of vitiligo or autoimmune diseases. Patients with halo nevi were no more likely to develop new areas of vitiligo during the follow-up period, but there was a nonsignificant trend toward a higher rate of repigmentation in vitiligo associated with halo nevus.
  
  
  CONCLUSIONS
  Halo nevi are a common finding in children with vitiligo. The presence of a halo nevus in a child with vitiligo is associated with generalized vitiligo. The presence of a halo nevus does not significantly alter the risk of disease progression and rate of treatment.
authors.affiliation: Ronald O. Perelman Department of Dermatology, School of Medicine, New York University, New York, New York.
authors.forename: Brandon E
authors.initials: BE
authors.lastname: Cohen
authors.affiliation: Ronald O. Perelman Department of Dermatology, School of Medicine, New York University, New York, New York.
authors.forename: Euphemia W
authors.initials: EW
authors.lastname: Mu
authors.affiliation: Ronald O. Perelman Department of Dermatology, School of Medicine, New York University, New York, New York.
authors.forename: Seth J
authors.initials: SJ
authors.lastname: Orlow
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D055882:Nevus, Halo / Q000175:diagnosis*; D012189:Retrospective Studies; D014820:Vitiligo / Q000175:diagnosis*