title: [Diagnostic value of FibroTest for liver fibrosis in patients with chronic hepatitis B].
abstract: OBJECTIVE
  To determine the diagnostic value of FibroTest (FT) for liver fibrosis in patients with chronic hepatitis B (CHB).
  
  
  METHODS
  One hundred and forty-two patients with CHB were tested for the following five indicators: alpha2-microglobulin (a2-MG), haptoglobin (Hp), gamma-glutarnyl peptidase (GGT), total bilirubin (TBIL), and apolipoprotein A1 (ApoA1). The resultant data, along with the age and sex of the patients, were put into an algorithm to compute the final results of the FT. During the same period of FT, all of the CHB patients underwent liver stiffness measurement by FibroScan (FS) as well as liver biopsy. Considering the liver biopsy as the gold standard, we determined receiver operating characteristic (ROC) curves at different endpoints. Calculation of the area under the ROC curves (AUROC) was performed to evaluate the diagnostic importance of FT, FS towards the treatment of liver fibrosis in patients with CHB.
  
  
  RESULTS
  Significant fibrosis (Scheuer score (S) more than or equal to 2) was predicted with an AUROC for FS, FT of 0.827 (0.753-0.900), 0.897 (0.844-0.949). Significant fibrosis (S more than or equal to 3) was predicted with an AUROC for FS, FT of 0.883 (0.818-0.949), 0.968 (0.932-1.00). Significant fibrosis (S=4) was predicted with an AUROC for FS, FT of 0.943 (0.893-0.993), 0.991 (0.973-1.00).
  
  
  CONCLUSIONS
  s FT is a novel tool that can be used to assess the degree of fibrosis in patients with CHB.
authors.affiliation: Department of Chronic Liver Diseases, Tianjin Second People's Hospital, Tianjin 300192, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wang
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Cheng
authors.forename: Chao
authors.initials: C
authors.lastname: Meng
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
mesh_terms: D016632:Apolipoprotein A-I; D019540:Area Under Curve; D001663:Bilirubin; D001706:Biopsy; D006242:Haptoglobins; D019694:Hepatitis B, Chronic; D006801:Humans; D008103:Liver Cirrhosis; D012372:ROC Curve
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D006242:Haptoglobins; D001663:Bilirubin