title: Salivary Gland Malignancies.
abstract: Salivary gland malignant tumors represent a diverse group of neoplasms. Their low incidence makes research studies challenging, with most therapeutic recommendations based on case reviews, single-arm trials, or small randomized trials. The standard of care for localized disease is surgical resection. Radiotherapy is the preferred local therapy when surgery is not possible or if there is significant morbidity. When symptomatic metastatic disease develops, systemic therapy is considered. Recent trial accrual success with a cooperative group, treatments based on defined molecular targets, and the development of immunotherapies all hold promise in improving the care of patients with these tumors.
authors.affiliation: Division of Medical Oncology, Department of Medicine, University of Washington, 825 Eastlake Avenue East, MS G4940, Seattle, WA 98109, USA.
authors.forename: Cristina P
authors.initials: CP
authors.lastname: Rodriguez
authors.affiliation: Division of Radiation Oncology, Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box, Seattle, WA 98195, USA.
authors.forename: Upendra
authors.initials: U
authors.lastname: Parvathaneni
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Washington, 1959 Northeast Pacific Street, Box 356515, Seattle, WA 98195, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1959 Northeast Pacific Street, Box 356515, Seattle, WA 98195, USA.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Méndez
authors.affiliation: Division of Medical Oncology, Department of Medicine, University of Washington, 825 Eastlake Avenue East, MS G4940, Seattle, WA 98109, USA. Electronic address: rgmart@uw.edu.
authors.forename: Renato G
authors.initials: RG
authors.lastname: Martins
mesh_terms: D001706:Biopsy; D003131:Combined Modality Therapy / Q000379:methods; D019468:Disease Management; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D012106:Research; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome
keywords: Management; Review; Salivary cancer; Systemic; Therapy