title: Predicting future trends in the burden of pertussis in the 21st century: implications for infant pertussis and the success of maternal immunization.
abstract: Support is growing for maternal immunization using acellular pertussis (aP) vaccines to prevent severe pertussis disease and deaths among very young, unvaccinated infants. Vaccine effectiveness of maternal immunization is 91% in preventing laboratory-confirmed pertussis in infants aged <3 months. To date, most mothers were primed in childhood with whole-cell pertussis vaccines. Soon, the generation of aP-primed individuals will become the new mothers-to-be. The shorter duration of protection afforded by aP vaccines, which is more pronounced with repeated aP boosters, may lead to increased pertussis circulation among aP-primed parents. Maternal Tdap immunization in aP-primed mothers-to-be may become less effective. Additional measures to protect young infants may eventually be needed, along with new vaccines that induce higher quality and more durable responses.
authors.affiliation: a Wesfarmers Centre of Vaccines and Infectious Diseases , Telethon Kids Institute , Subiaco , WA 6008 , Australia.
authors.forename: Anita H J
authors.initials: AH
authors.lastname: van den Biggelaar
authors.forename: Jan T
authors.initials: JT
authors.lastname: Poolman
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007114:Immunization / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D011247:Pregnancy; D022282:Vaccines, Acellular / Q000008:administration & dosage / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D010567:Pertussis Vaccine; D022282:Vaccines, Acellular
keywords: Pertussis; acellular pertussis vaccine; antigenic sin; maternal immunization; pertussis toxin; pertussis vaccine