title: Posterior capsule opacity in Retinitis Pigmentosa according to different biomaterials of intraocular lenses: Our clinical experience.
abstract: OBJECTIVE
  Complicated Cataract is frequently associated with Retinitis Pigmentosa (RP). This retinopathy is a great cause of visual impairment, and cataract surgery may resolve partially the situation and restore sight. Unfortunately, in this case there is a very high incidence of Posterior Capsule Opacity (PCO) ranging in several studies a percentage of 100% at six months. Our goal was to evaluate whether the high incidence of PCO is associated to specific type of Intraocular Lens (IOL) biomaterials.
  
  
  METHODS
  This observational retrospective study deals with 75 eyes of 43 patients affected with RP who underwent to cataract surgery with posterior chamber IOL implants (40% ECCE and 60% Phaco). Selected biomaterials were: 30 Poly (methyl methacrylate) (PMMA), 11 silicone, 34 acrylic. Observations were performed with retro-illumination camera and when recorded capsular fibrosis a PCO YAG laser capsulotomy was made. The patients were controlled at 3-6-12 months after the initial surgical treatment.
  
  
  RESULTS
  At three months of follow up, 80% of patients with PMMA, 81.8% silicone implants underwent to YAG capsulotomy while only 44% of acrylic type. At six months of follow-up 83.3% of patients with PMMA and 81.8% silicone implants underwent to YAG capsulotomy while only 49.88% of acrylic type. At 12 months of follow up 89.9% of patients with PMMA and 90.95 silicone implants underwent to YAG capsulotomy while only 52.82% of acrylic type.
  
  
  CONCLUSIONS
  We could not be able to differentiate incidence between different brand type of lens in PMMA. For Acrylic lens instead we noted an incidence of PCO of 41.38% with hydrophobic material and 60.0% of hydrophilic material. In conclusion to avoid massive PCO in RP, our experience is statistically significant, in fact the protective action of smooth material hydrophobic lens avoids the epithelial growth and fibrosis towards the center of visual axis.
authors.affiliation: Institute of Ophthalmic Sciences , "Sapienza" University of Rome, "Polo Pontino", Terracina, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bruno
authors.affiliation: Institute of Ophthalmic Sciences , "Sapienza" University of Rome, "Polo Pontino", Terracina, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Nebbioso
authors.affiliation: Institute of Ophthalmic Sciences , "Sapienza" University of Rome, "Polo Pontino", Terracina, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Rigoni
authors.affiliation: Institute of Ophthalmic Sciences , "Sapienza" University of Rome, "Polo Pontino", Terracina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gagliardi
authors.affiliation: Institute of Ophthalmic Sciences , "Sapienza" University of Rome, "Polo Pontino", Terracina, Italy.
authors.forename: E M
authors.initials: EM
authors.lastname: Vingolo
mesh_terms: D000180:Acrylic Resins / Q000009:adverse effects; D000328:Adult; D000368:Aged; D001672:Biocompatible Materials / Q000009:adverse effects; D058442:Capsule Opacification / Q000209:etiology*; D002387:Cataract Extraction / Q000009:adverse effects*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D019904:Polymethyl Methacrylate; D057852:Posterior Capsule of the Lens / Q000473:pathology*; D019591:Pseudophakia / Q000150:complications; D012174:Retinitis Pigmentosa / Q000209:etiology*; D012189:Retrospective Studies; D012826:Silicone Elastomers / Q000009:adverse effects
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D012826:Silicone Elastomers; D019904:Polymethyl Methacrylate
keywords: Biomaterials; Intraocular Lens; Posterior capsule opacity; Retinitis pigmentosa