title: [Risk factors of 125 cases of neonatal congenital hypothyroidism during perinatal period].
abstract: OBJECTIVE
  To understand the relationship between perinatal factors and congenital hypothyroidism (CH) and provide scientific evidence for the prevention of CH.
  
  
  METHODS
  A case-control study was conducted among 125 neonates with CH (case group) and 375 neonates without CH (control group) in Fujian Neonatal Screening Center from January in 2012 to December in 2013. Univariate and multivariate logistic regression analysis were performed to identify the risk factors to CH during perinatal period.
  
  
  RESULTS
  Univariate logistic regression analysis indicated that compared with control group, gestational hypertension, gestational diabetes mellitus, gestational thyroid disease and older age of mother were the risk factors to CH, the difference was statistically significant (P < 0.05) and the risk of CH was higher in female babies, preterm babies, post-term babies low birth weight babies, macrosomia, twins, babies with birth defects and infection in cases group than those in control group, the difference was statistically significant (P < 0.05). Multivariate logistic analysis showed that older age of mother (OR = 2.518, 95% CI: 1.186-5.347), gestational diabetes mellitus (OR = 1.904, 95% CI: 1.190-3.045), gestational hypothyroidism or hyperthyroidism (OR = 12.883 and 30.797, 95% CI: 2.055-80.751 and 3.309-286.594), preterm birth (OR = 4.238, 95% CI: 1.269-14.155), and post-term birth (OR = 12.799, 95% CI: 1.257-130.327), low birth weight (OR = 3.505, 95% CI: 1.059-11.601), macrosomia (OR = 3.733, 95% CI: 1.415-9.851), twin or multiparous delivery (OR = 5.493, 95% CI: 1.701-17.735), birth defects (OR = 3.665, 95% CI: 1.604-8.371) and fetal distress (OR = 3.130, 95% CI: 1.317-7.440) were the high risk factors to CH (P < 0.05).
  
  
  CONCLUSIONS
  CH was correlated with mother's age, gestational diabetes, gestational thyroid disease as well as neonate's birth weight and gestational age, foetus number, fetal distress and other complicated birth defects at certain degree. More attention should be paid to perinatal care to reduce risk factors and the incidence of CH.
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.
authors.forename: Jinfu
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Women Health Care, Fuzhou 350001, China.
authors.forename: Jinying
authors.initials: J
authors.lastname: Luo
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.
authors.forename: Honghua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Su
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.
authors.forename: Yinglin
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China.
authors.forename: Qingying
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Fujian Provincial Maternity and Child Care Hospital, Teaching Hospital of Fujian Medical University, Fujian Neonatal Screening Center, Fuzhou 350001, China; Email: fjnsczwb@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zhu
mesh_terms: D001724:Birth Weight; D016022:Case-Control Studies; D003409:Congenital Hypothyroidism / Q000453:epidemiology*; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D008423:Maternal Age; D015997:Neonatal Screening; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D047928:Premature Birth; D012307:Risk Factors; D014427:Twins