title: Four New Flavonoids with α-Glucosidase Inhibitory Activities from Morus alba var. tatarica.
abstract: Four new flavonoids, mortatarins A-D (1-4, resp.), along with eight known flavonoids (5-12) were isolated from the root bark of Morus alba var. tatarica. Their structures were established on the basis of spectroscopic data analysis, and the absolute configuration of 4 was determined by analysis of its CD spectrum. All isolates were tested for inhibitory activities against α-glucosidase. Compounds 4, 7, and 8 exhibited a significant degree of inhibition with IC50 values of 5.0 ± 0.3, 7.5 ± 0.5, and 5.9 ± 0.2 μM, respectively.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China, (phone/fax: +86-25-83271405).
authors.forename: Ya-Long
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China, (phone/fax: +86-25-83271405). luojg99@163.com.
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Luo
authors.affiliation: Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Group, Tarim University, Alaer 843300, P. R. China.
authors.forename: Chuan-Xing
authors.initials: CX
authors.lastname: Wan
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China, (phone/fax: +86-25-83271405).
authors.forename: Zhong-Bo
authors.initials: ZB
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China, (phone/fax: +86-25-83271405). cpu_lykong@126.com.
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D031625:Morus / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D013329:Structure-Activity Relationship; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; D000520:alpha-Glucosidases
keywords: Flavonoids; Mortatarins A - D; Morus alba; α-Glucosidase