title: Effectiveness of rehabilitation in multiple sclerosis relapse on fatigue, self-efficacy and physical activity.
abstract: Relapse of disease is one of the most prominent characteristics of multiple sclerosis. Effectiveness of rehabilitation programmes on fatigue, self-efficacy (SE) and physical activity (PA) has not been investigated so far in context of relapse. The aim of our study was to examine if rehabilitation programme in addition to high-dose methylprednisolone (HDMP) during relapse of disease can influence fatigue, SE and PA more than corticosteroid therapy alone. Patients were randomized in control group receiving only HDMP and experimental group which was in addition included in rehabilitation programme. Outcome measures used were Fatigue Severity Scale (FSS), Multiple Sclerosis Self- Efficacy scale (MSSES), Godin Leisure-Time Exercise Questionnaire (GLTEQ), completed on baseline, 1 and 3 months later. There was no significant change in FSS in both time points, despite different trend seen between groups. The mean MSSES for function and control improved significantly in treatment group after 1 month (807.1 ± 96.8, p = 0.005; 665.3 ± 145.1, p = 0.05) and 3 months (820 ± 83.5, p = 0.004; 720.0 ± 198.2, p = 0.016.) compared to baseline values. The mean GLTEQ score was significantly higher in the treatment group compared to the control at both follow-up time points (45.7 ± 7.6, p < 0.001; 34.3 ± 22.4, p < 0.01). Rehabilitation started along with corticosteroid treatment induced significant improvement in PA compared to HDMP therapy alone. It also influenced noticeable changes in self-efficacy, but effect on fatigue was insufficient.
authors.affiliation: Clinic for Physical Medicine and Rehabilitation, Clinical Centre of Serbia, Pasterova 2, 11000, Belgrade, Serbia. unaned@gmail.com.|School of Medicine, University of Belgrade, Doktora Subotica 8, 11000, Belgrade, Serbia. unaned@gmail.com.
authors.forename: Una
authors.initials: U
authors.lastname: Nedeljkovic
authors.affiliation: Clinic for Physical Medicine and Rehabilitation, Clinical Centre of Serbia, Pasterova 2, 11000, Belgrade, Serbia.|School of Medicine, University of Belgrade, Doktora Subotica 8, 11000, Belgrade, Serbia.
authors.forename: Emilija Dubljanin
authors.initials: ED
authors.lastname: Raspopovic
authors.affiliation: Clinic for Physical Medicine and Rehabilitation, Clinical Centre of Serbia, Pasterova 2, 11000, Belgrade, Serbia.|School of Medicine, University of Belgrade, Doktora Subotica 8, 11000, Belgrade, Serbia.
authors.forename: Nela
authors.initials: N
authors.lastname: Ilic
authors.affiliation: Clinic for Physical Medicine and Rehabilitation, Clinical Centre of Serbia, Pasterova 2, 11000, Belgrade, Serbia.|School of Medicine, University of Belgrade, Doktora Subotica 8, 11000, Belgrade, Serbia.
authors.forename: Sanja Tomanovic
authors.initials: ST
authors.lastname: Vujadinovic
authors.affiliation: School of Medicine, University of Belgrade, Doktora Subotica 8, 11000, Belgrade, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Soldatovic
authors.affiliation: School of Medicine, University of Belgrade, Doktora Subotica 8, 11000, Belgrade, Serbia.|Neurology Clinic, Clinical Centre of Serbia, Doktora Subotica 6, 11000, Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Drulovic
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D015444:Exercise / Q000502:physiology*; D005221:Fatigue / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000534:rehabilitation*; D011788:Quality of Life; D012008:Recurrence; D020377:Self Efficacy; D011795:Surveys and Questionnaires
keywords: Fatigue; Multiple sclerosis; Physical activity; Rehabilitation; Relapsing-remitting; Self-efficacy