title: Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus).
abstract: Organophosphate flame retardants (OPFRs) have been detected at high concentrations in various environmental and biotic samples, but little is known about their toxicity. In this study, the potential neurotoxicity of three OPFRs (TCEP, TDCPP, and TPP) and Chlorpyrifos (CPF, an organophosphate pesticide) were compared in Chinese rare minnow using an acute toxicity test and a 21-day fish assay. The acute test demonstrated significant inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by CPF. Although significant AChE inhibition at high concentration of TPP was also observed, none of the OPFRs had effects similar to CPF on these enzymes, indicating that their acute toxicities to Chinese rare minnow may be unrelated to cholinesterase inhibition. In addition, the 21-day fish assay with TDCPP demonstrated no significant effects on cholinesterase activities or neurotransmitter levels. Nonetheless, this OPFR exhibited widespread effects on the neurotrophic factors and their receptors (e.g., ntf3, ntrk1, ntrk2, ngfr, and fgf2, fgf11, fgf22, fgfr4), indicating that TDCPP or other OPFRs may elicit neurological effects by targeting neurotrophic factors and their receptors in Chinese rare minnow.
authors.affiliation: Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: Lilai
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: Jiasu
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Beijing Key Laboratory of Industrial Wastewater Treatment and Reuse, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address: jmzha@rcees.ac.cn.
authors.forename: Jinmiao
authors.initials: J
authors.lastname: Zha
authors.affiliation: State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D004390:Chlorpyrifos / Q000633:toxicity; D002802:Cholinesterases / Q000378:metabolism; D003530:Cyprinidae / Q000378:metabolism*; D005411:Flame Retardants / Q000633:toxicity*; D006801:Humans; D007306:Insecticides / Q000633:toxicity; D009414:Nerve Growth Factors / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000633:toxicity*; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D018675:Toxicity Tests
chemical_list: D005411:Flame Retardants; D007306:Insecticides; D009414:Nerve Growth Factors; D018377:Neurotransmitter Agents; D009943:Organophosphorus Compounds; D017475:Receptors, Nerve Growth Factor; C016805:tris(1,3-dichloro-2-propyl)phosphate; D002802:Cholinesterases; D004390:Chlorpyrifos
keywords: Chinese rare minnow; Cholinesterase and neurotransmitter systems; Neurological effects; Neurotrophic factors; Organophosphate flame retardants