title: Peripheral quantitative computed tomography (pQCT) bone measurements in children with cystic fibrosis.
abstract: BACKGROUND
  Individuals with cystic fibrosis (CF) have low bone density and increased fracture risk.
  
  
  METHODS
  Cross-sectional study investigating whole body bone mineral content (WBBMC), bone geometry and strength in 12 children with CF compared to 23 age- and sex-matched controls with and without adjusting for age, height, and body composition.
  
  
  RESULTS
  CF group had lower WBBMC than controls (P = 0.007) with larger differences at older ages (age-by-group, P = 0.08). CF group had decreased height (P = 0.006), a trend of lower lean mass per height (P = 0.08), and no difference in relationship between WBBMC and lean mass compared to controls (P = 0.65). Periosteal and endosteal circumferences were smaller in CF (each, P = 0.02). Positive relationships of cortical area and bone strength with age were attenuated with CF (group-by-age; each, P < 0.01).
  
  
  CONCLUSIONS
  Children with CF have similar WBBMC relative to lean mass as controls. Cortical bone area and bone strength were less in CF group compared to controls, with greater differences in older children.
authors.affiliation: EA Martin Program in Human Nutrition, SWC Box 506, South Dakota State University, South Dakota.
authors.forename: Wei
authors.initials: W
authors.lastname: Bai
authors.affiliation: EA Martin Program in Human Nutrition, SWC Box 506, South Dakota State University, South Dakota.
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Binkley
authors.affiliation: Sanford Children's Specialty Clinic, 1600 W. 22nd Street, Sioux Falls, South Dakota.
authors.forename: James W
authors.initials: JW
authors.lastname: Wallace
authors.affiliation: Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, Missouri.
authors.forename: Terrence W
authors.initials: TW
authors.lastname: Carver
authors.affiliation: EA Martin Program in Human Nutrition, SWC Box 506, South Dakota State University, South Dakota.
authors.forename: Bonny L
authors.initials: BL
authors.lastname: Specker
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D001823:Body Composition / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002648:Child; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male
keywords: DXA; bone size; bone strength; cystic fibrosis; whole body bone mineral content