title: Docosapentaenoic acid derived metabolites and mediators - The new world of lipid mediator medicine in a nutshell.
abstract: Recent years have seen the description and elucidation of a new class of anti-inflammatory and pro-resolving lipid mediators. The arachidonic acid (AA)-derived compounds in this class are called lipoxins and have been described in great detail since their discovery thirty years ago. The new players are mediators derived from fish oil omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), called resolvins, protectins and maresins. Taken together, these mediators are also called specialized pro-resolution mediators (SPMs). As compared to the AA/EPA/DHA-derived compounds, research regarding mediators formed from the n-3 and n-6 docosapentaenoic acids (DPAn-3 and DPAn-6) is sparse. However, mono- di- and trihydroxy derivates of the DPAs have anti-inflammatory properties as well, even though mechanisms of their anti-inflammatory action have not been fully elucidated. This review aims to summarize current knowledge regarding the DPA-derived SPMs and their actions.
authors.affiliation: Medical Department, Division of Hepatology and Gastroenterology (including Metabolic Diseases), Charité University Medicine, Campus Virchow Hospital, Berlin, Germany; Lipid Clinic, Experimental and Clinical Research Centre (ECRC), Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany. Electronic address: karsten.weylandt@charite.de.
authors.forename: Karsten-H
authors.initials: KH
authors.lastname: Weylandt
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans
chemical_list: D005231:Fatty Acids, Unsaturated; C026219:docosapentaenoic acid
keywords: 4,7,10,13,16-Docosapentaenoic acid (PubChem CID: 5282848); 7,10,13,16,19-Docosapentaenoic acid (PubChem CID: 5497182); DPA; Docosapentaenoic acid; Omega-3 polyunsaturated fatty acids; Omega-6 polyunsaturated fatty acids; Resolvin; Specialized pro-resolution mediators