title: [Morphology of Hypertrophic Scar Tissues and Expressions of Vascular Endothelial Growth Factor and Transforming Growth Factor Beta Activated Kinase 1 in These Tissues].
abstract: OBJECTIVE
  To observe the morphology of hypertrophic scar tissue and explore the expressions and distribution of vascular endothelial growth factor (VEGF) and transforming growth factor beta activated kinase 1(TAK1 )in these tissues.
  
  
  METHODS
  Hematoxylin-eosin staining, Masson staining,immunofluorescence,and real-time polymerase chain reaction were used to detect the localization and expression of VEGF and TAK1 in 15 hypertrophic scar tissues and 10 normal skin tissues.
  
  
  RESULTS
  Morphological observation showed that the dermal fibroblasts in hypertrophic scar were disorderly and densely arranged (compared to the normal skin). Immunofluorescence displayed that the expressions of VEGF and TAK1 in hypertrophic scar tissue were higher than in normal skin tissues. Real-time polymerase chain reaction showed the mRNA expressions of both VEGF and TAK1 were significantly higher in hypertrophic scar tissue than in normal tissue (P<0.01, P<0.05,respectively).
  
  
  CONCLUSIONS
  Hypertrophic scar tissue has higher collagen fibrosis degree and higher TAK1 and VEGF expressions than the normal skin. VEGF and TAK1 can be used as the reference indicators for the diagnosis and differential diagnosis of hypertrophic scar and serve as new therapeutic targets.
authors.affiliation: Medical Research Center,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China2Department of Pharmacology,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China3Department of Burn Surgery,the 209 Hospital of Chinese People's Liberation Army,Mudanjiang,Heilongjiang 157011,China.
authors.forename: Yu-fei
authors.initials: YF
authors.lastname: Zhang
authors.forename: Hou-zhong
authors.initials: HZ
authors.lastname: Li
authors.forename: Xue-yong
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Medical Research Center,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China2Department of Pharmacology,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China3Department of Burn Surgery,the 209 Hospital of Chinese People's Liberation Army,Mudanjiang,Heilongjiang 157011,China.
authors.forename: Hong-chuang
authors.initials: HC
authors.lastname: Ma
authors.affiliation: Medical Research Center,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China2Department of Pharmacology,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China3Department of Burn Surgery,the 209 Hospital of Chinese People's Liberation Army,Mudanjiang,Heilongjiang 157011,China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Medical Research Center,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China2Department of Pharmacology,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China3Department of Burn Surgery,the 209 Hospital of Chinese People's Liberation Army,Mudanjiang,Heilongjiang 157011,China.
authors.forename: Xiao-huan
authors.initials: XH
authors.lastname: Yuan
authors.affiliation: Medical Research Center,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China2Department of Pharmacology,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China3Department of Burn Surgery,the 209 Hospital of Chinese People's Liberation Army,Mudanjiang,Heilongjiang 157011,China.
authors.forename: Yan-hui
authors.initials: YH
authors.lastname: Chu
mesh_terms: D048430:Cell Shape; D017439:Cicatrix, Hypertrophic; D003094:Collagen; D005347:Fibroblasts; D006801:Humans; D020930:MAP Kinase Kinase Kinases; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D000099151:MAP Kinase Kinase Kinase 7
chemical_list: D003094:Collagen; D020930:MAP Kinase Kinase Kinases; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D000099151:MAP Kinase Kinase Kinase 7