title: Syringomatous adenoma of the nipple: a case report.
abstract: BACKGROUND
  Syringomatous adenoma of the nipple is a very rare benign tumor. To the best of our knowledge, there are no reports of a syringomatous adenoma of the nipple metastasizing, although these tumors are known to infiltrate locally and to recur if not totally resected.
  
  
  METHODS
  Our patient was a 41-year-old Japanese woman who complained of stiffness of her right nipple with abnormal discharge. Local resection of the tumor was performed. The pathological diagnosis was syringomatous adenoma of the nipple, and the resection margin was found to be positive. Accordingly, additional resection was recommended, but our patient did not allow another operation. After 1.5 years of careful follow-up, no local recurrence or distant metastasis has been observed.
  
  
  CONCLUSIONS
  The optimal initial management of syringomatous adenoma of the nipple demands complete resection with histologically negative margins. However, from a cosmetic viewpoint, nipple-sparing resection could represent an alternative option for the treatment of syringomatous adenoma of the nipple.
authors.affiliation: Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan. shoichi782@gmail.com.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ishikawa
authors.affiliation: Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Sako
authors.affiliation: Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Masuda
authors.affiliation: Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of Surgery, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Akioka
authors.affiliation: Department of Pathology and Laboratory Medicine, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Pathology and Laboratory Medicine, Omihachiman Community Medical Center, 1379 Tsuchida-cho, Omihachiman City, Shiga, 523-0082, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Hosokawa
authors.affiliation: Research Institute, Shiga Medical Center for Adults, 5-4-30, Moriyama, Moriyama City, Shiga, 524-8524, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Manabe
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009558:Nipples / Q000473:pathology*; D011379:Prognosis; D018252:Syringoma / Q000175:diagnosis* / Q000473:pathology; D016896:Treatment Outcome