title: Hepatitis C virus infection: Are there still specific problems with genotype 3?
abstract: Hepatitis C virus (HCV) infection is one of the most common causes of chronic liver disease and the main indication for liver transplantation worldwide. As promising specific treatments have been introduced for genotype 1, clinicians and researchers are now focusing on patients infected by non-genotype 1 HCV, particularly genotype 3. Indeed, in the golden era of direct-acting antiviral drugs, genotype 3 infections are no longer considered as easy to treat and are associated with higher risk of developing severe liver injuries, such as cirrhosis and hepatocellular carcinoma. Moreover, HCV genotype 3 accounts for 40% of all HCV infections in Asia and is the most frequent genotype among HCV-positive injecting drug users in several countries. Here, we review recent data on HCV genotype 3 infection/treatment, including clinical aspects and the underlying genotype-specific molecular mechanisms.
authors.affiliation: Claire Gondeau, Georges Philippe Pageaux, Dominique Larrey, Department of Hepato-gastroenterology A, Hospital Saint Eloi, CHRU, 34295 Montpellier, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Gondeau
authors.affiliation: Claire Gondeau, Georges Philippe Pageaux, Dominique Larrey, Department of Hepato-gastroenterology A, Hospital Saint Eloi, CHRU, 34295 Montpellier, France.
authors.forename: Georges Philippe
authors.initials: GP
authors.lastname: Pageaux
authors.affiliation: Claire Gondeau, Georges Philippe Pageaux, Dominique Larrey, Department of Hepato-gastroenterology A, Hospital Saint Eloi, CHRU, 34295 Montpellier, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Larrey
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D005838:Genotype; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics; D006526:Hepatitis C / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents
keywords: Direct-acting antivirals; Genotype 3; Hepatitis C; Hepatocellular carcinoma; Interferon