title: A Near-Infrared Laser-Activated "Nanobomb" for Breaking the Barriers to MicroRNA Delivery.
abstract: A near-infrared laser-activated "nanobomb" is synthesized using lipid and multiple polymers to break the extra-cellular and intracellular barriers to cytosolic delivery of microRNAs. The nanobomb can be used to effectively destroy tumors and cancer stem-like cells in vitro and in vivo with minimal side effects.
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA.|Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA.|Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Pranay
authors.initials: P
authors.lastname: Agarwal
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA.|Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Shuting
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.|Division of Hematology, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
authors.forename: Xiongbin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA.|Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: He
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000503:physiopathology / Q000628:therapy; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000502:physiology / Q000528:radiation effects; D011992:Endosomes / Q000378:metabolism / Q000528:radiation effects; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D008247:Lysosomes / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008819:Mice, Nude; D035683:MicroRNAs / Q000008:administration & dosage*; D053758:Nanoparticles / Q000737:chemistry / Q000528:radiation effects*; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000502:physiology / Q000528:radiation effects; D011471:Prostatic Neoplasms / Q000503:physiopathology / Q000628:therapy; D047368:Tumor Burden / Q000502:physiology / Q000528:radiation effects
chemical_list: D018960:Hyaluronan Receptors; D035683:MicroRNAs
keywords: cancer stem-like cells; endosomal escape; gene delivery; microRNAs; nanoparticles