title: The Estrogen Receptor-β Expression in De Quervain's Disease.
abstract: Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain's disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation of estrogen receptor (ER)-β expression to determine whether estrogen is involved in the pathogenesis of de Quervain's. Intraoperative retinaculum samples were collected from 16 patients with the ailment. Specimens were histologically graded by collagen structure and immunohistochemically evaluated by quantifying the expression of ER-β, interleukin (IL)-1β and IL-6 (inflammatory cytokines), cyclooxygenase (COX)-2 (an inflammatory enzyme), and vascular endothelial growth factor (VEGF), and Von Willebrand's factor (vWF). De Quervain's occurs primarily in women. The female:male ratio in our study was 7:1. We found that ER-β expression in the retinaculum was positively correlated with disease grade and patient age. Additionally, disease severity was associated with inflammatory factors--IL-1β and IL-6, COX-2, and VEGF and vWF in tenosynovial tissue. The greater the levels of ER-β expression, tissue inflammation, and angiogenesis are, the more severe de Quervain's disease is. ER-β might be a useful target for novel de Quervain's disease therapy.
authors.affiliation: Department of Orthopedics, Tainan Hospital, Ministry of Health and Welfare, Tainan 70043, Taiwan. bcshen58@yahoo.com.tw.
authors.forename: Po-Chuan
authors.initials: PC
authors.lastname: Shen
authors.affiliation: Department of Orthopedics, Chi-Mei Medical Center, Tainan 71004, Taiwan. justin2051278@yahoo.com.
authors.forename: Ping-Hui
authors.initials: PH
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, National Cheng Kung University College of Medicine, 1 Dashuei Road, Tainan 70101, Taiwan. anotherme500@gmail.com.
authors.forename: Po-Ting
authors.initials: PT
authors.lastname: Wu
authors.affiliation: Department of Orthopedics, Kuo's General Hospital, Tainan 70054, Taiwan. m004409@gmail.com.
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Wu
authors.affiliation: Department of Nursing, Chung Hwa University of Medical Technology, 89 Wenhua 1st Street, Rende District, Tainan 71703, Taiwan. jenglonghsieh@gmail.com.
authors.forename: Jeng-Long
authors.initials: JL
authors.lastname: Hsieh
authors.affiliation: Department of Orthopedics, National Cheng Kung University College of Medicine, 1 Dashuei Road, Tainan 70101, Taiwan. jming@mail.ncku.edu.tw.
authors.forename: I-Ming
authors.initials: IM
authors.lastname: Jou
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D043925:Angiogenesis Inducing Agents / Q000378:metabolism; D016022:Case-Control Studies; D053684:De Quervain Disease / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D047629:Estrogen Receptor beta / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D043925:Angiogenesis Inducing Agents; D047629:Estrogen Receptor beta; D018836:Inflammation Mediators
keywords: angiogenesis; de Quervain’s disease; estrogen receptor-β; inflammation