title: A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages.
abstract: The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using in silico bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages.
authors.affiliation: Department of Physiology, School of Medicine, Konkuk University, Chungju 27478, Korea.
authors.forename: Kyung-Jong
authors.initials: KJ
authors.lastname: Won
authors.affiliation: Departmet of Biomedical Science, College of Life Science, CHA University, Seongnam 13496, Korea.
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Park
authors.affiliation: National Institute of Animal Science, RDA, Wanju 55365, Korea.
authors.forename: Seunghoon
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Animal Sciences, Division of Applied Life Science, Gyeongsang National University, Jinju 52828, Korea.
authors.forename: Il-Keun
authors.initials: IK
authors.lastname: Kong
authors.affiliation: Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 plus, Chonbuk National University, Jeonju 54907, Korea.
authors.forename: Jung-Il
authors.initials: JI
authors.lastname: Chae
authors.affiliation: Department of Physiology, School of Medicine, Konkuk University, Chungju 27478, Korea.
authors.forename: Bokyung
authors.initials: B
authors.lastname: Kim
authors.affiliation: CHA Biotech. Co., Ltd., Seoul 05053, Korea.
authors.forename: Eun-Jong
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Nuri Science Co., Ltd., Seoul 05053, Korea.
authors.forename: Dong-Ku
authors.initials: DK
authors.lastname: Kim
keywords: Anti-proliferation; ITIM motif; Macrophages; TLT-6; TREM family