title: [At the border of pluri- and multipotency: the neural crest stem cells].
abstract: The neural crest is a transient, multipotent, migratory cell population that is unique to vertebrate embryos and gives rise to many derivatives, ranging from the neuronal and glial components of the peripheral nervous system to the ectomesenchymal derivatives of the craniofacial area and pigment cells in the skin. Intriguingly, the neural crest derived stem cells are not only present in the embryonic neural crest, but also in their target tissues in the fetus and adult. These postmigratory stem cells, at least partially, resemble their multipotency. Moreover, fully differentiated neural crest-derived cells such as Schwann cells and melanocytes are able to dedifferentiate into stem-like progenitors. Here the authors review current understanding of this unique plasticity and its potential application in stem cell biology as well as in regenerative medicine.
authors.affiliation: Enzimológiai Intézet, Magyar Tudományos Akadémia, Természettudományi Kutatóközpont Budapest.
authors.forename: Gyöngyi
authors.initials: G
authors.lastname: Kudlik
authors.affiliation: Enzimológiai Intézet, Magyar Tudományos Akadémia, Természettudományi Kutatóközpont Budapest.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Matula
authors.affiliation: Enzimológiai Intézet, Magyar Tudományos Akadémia, Természettudományi Kutatóközpont Budapest.
authors.forename: Tamás
authors.initials: T
authors.lastname: Kovács
authors.affiliation: Morfológiai és Fiziológiai Tanszék, Semmelweis Egyetem, Egészségtudományi Kar Budapest.
authors.forename: S Veronika
authors.initials: SV
authors.lastname: Urbán
authors.affiliation: Országos Vérellátó Szolgálat Budapest, Karolina út 19-21., 1113.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Uher
mesh_terms: D000818:Animals; D054337:Cell Dedifferentiation; D002454:Cell Differentiation; D002465:Cell Movement; D006801:Humans; D008544:Melanocytes / Q000502:physiology; D039902:Multipotent Stem Cells / Q000502:physiology; D009432:Neural Crest / Q000166:cytology*; D039904:Pluripotent Stem Cells / Q000502:physiology; D012583:Schwann Cells / Q000502:physiology; D013234:Stem Cells / Q000502:physiology
keywords: ectomesenchyma; ectomesenchyme; ganglionléc; neural crest; plasticity; plaszticitás; stem cells; őssejtek