title: The effect of a dietary portfolio compared to a DASH-type diet on blood pressure.
abstract: OBJECTIVE
  Compared to a DASH-type diet, an intensively applied dietary portfolio reduced diastolic blood pressure at 24 weeks as a secondary outcome in a previous study. Due to the importance of strategies to reduce blood pressure, we performed an exploratory analysis pooling data from intensively and routinely applied portfolio treatments from the same study to assess the effect over time on systolic, diastolic and mean arterial pressure (MAP), and the relation to sodium (Na(+)), potassium (K(+)), and portfolio components.
  
  
  RESULTS
  241 participants with hyperlipidemia, from four academic centers across Canada were randomized and completed either a DASH-type diet (control n = 82) or a dietary portfolio that included, soy protein, viscous fibers and nuts (n = 159) for 24 weeks. Fasting measures and 7-day food records were obtained at weeks 0, 12 and 24, with 24-h urines at weeks 0 and 24. The dietary portfolio reduced systolic, diastolic and mean arterial blood pressure compared to the control by 2.1 mm Hg (95% CI, 4.2 to -0.1 mm Hg) (p = 0.056), 1.8 mm Hg (CI, 3.2 to 0.4 mm Hg) (p = 0.013) and 1.9 mm Hg (CI, 3.4 to 0.4 mm Hg) (p = 0.015), respectively. Blood pressure reductions were small at 12 weeks and only reached significance at 24 weeks. Nuts, soy and viscous fiber all related negatively to change in mean arterial pressure (ρ = -0.15 to -0.17, p ≤ 0.016) as did urinary potassium (ρ = -0.25, p = 0.001), while the Na(+)/K(+) ratio was positively associated (ρ = 0.20, p = 0.010).
  
  
  CONCLUSIONS
  Consumption of a cholesterol-lowering dietary portfolio also decreased blood pressure by comparison with a healthy DASH-type diet. CLINICAL TRIAL REG. NO.: NCT00438425, clinicaltrials.gov.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. Electronic address: NutritionProject@smh.ca.
authors.forename: D J A
authors.initials: DJ
authors.lastname: Jenkins
authors.affiliation: Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: P J
authors.initials: PJ
authors.lastname: Jones
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Frohlich
authors.affiliation: School of Nutrition, Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Lamarche
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Ireland
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: S K
authors.initials: SK
authors.lastname: Nishi
authors.affiliation: Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Srichaikul
authors.affiliation: Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Galange
authors.affiliation: Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Pellini
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Faulkner
authors.affiliation: Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada.
authors.forename: R J
authors.initials: RJ
authors.lastname: de Souza
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: J L
authors.initials: JL
authors.lastname: Sievenpiper
authors.affiliation: Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Mirrahimi
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: V H
authors.initials: VH
authors.lastname: Jayalath
authors.affiliation: Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: L S
authors.initials: LS
authors.lastname: Augustin
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Bashyam
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: L A
authors.initials: LA
authors.lastname: Leiter
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Josse
authors.affiliation: Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Couture
authors.affiliation: Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Ramprasath
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital, Toronto, ON, Canada; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.
authors.forename: C W C
authors.initials: CW
authors.lastname: Kendall
mesh_terms: D000328:Adult; D000368:Aged; D001795:Blood Pressure Determination / Q000379:methods; D002170:Canada; D002318:Cardiovascular Diseases / Q000178:diet therapy* / Q000517:prevention & control; D015930:Diet Records; D018752:Diet, Fat-Restricted / Q000379:methods*; D038441:Diet, Mediterranean; D004039:Diet, Sodium-Restricted / Q000379:methods*; D002149:Energy Intake; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006949:Hyperlipidemias / Q000178:diet therapy* / Q000517:prevention & control; D006973:Hypertension / Q000178:diet therapy* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D016896:Treatment Outcome
keywords: Blood pressure; Cardiovascular disease; Coronary heart disease risk; Plant protein; Sodium; Vegetable protein