title: Effect of Intraperitoneal Thymoquinone on Postoperative Peritoneal Adhesions.
abstract: BACKGROUND
  To determine the effect of thymoquinone on adhesion formation in a rat caecotomy/suture model.
  
  
  METHODS
  Thirty wistar rats were randomized into three groups: The control group received saline and the thymoquinone group received 10 mg/kg thymoquinone after cecal caecotomy/suture model. In the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were classified, and histopathological samples were taken.
  
  
  RESULTS
  There were no incisional hernias or wound dehiscences. In comparing adhesion scores, a significant difference was found between the thymoquinone and the control groups (p < 0.05). The grade of inflammation for the thymoquinone and the sham groups were significantly lower than that of the control group (p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham and thymoquinone groups compared to the control group (p < 0.05).
  
  
  CONCLUSIONS
  Based on the results of this study in a rat peritoneal adhesion model, intraperitoneal administered thymoquinone has a strong anti-adhesive effect.
authors.affiliation: Department of General Surgery, Diyarbakir Dicle University Faculty of Medicine, Yenisehir-Diyarbakir, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Bozdag
authors.forename: M
authors.initials: M
authors.lastname: Gumus
authors.forename: Z
authors.initials: Z
authors.lastname: Arıkanoglu
authors.forename: I
authors.initials: I
authors.lastname: Ibiloglu
authors.forename: S
authors.initials: S
authors.lastname: Kaya
authors.forename: O
authors.initials: O
authors.lastname: Evliyaoglu
mesh_terms: D058107:Abdominal Wound Closure Techniques; D000818:Animals; D016227:Benzoquinones / Q000627:therapeutic use*; D002432:Cecum / Q000601:surgery*; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008297:Male; D010532:Peritoneal Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D011183:Postoperative Complications; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology / Q000517:prevention & control
chemical_list: D016227:Benzoquinones; C003466:thymoquinone