title: Capillary electrophoresis in metallodrug development.
abstract: Capillary electrophoresis (CE) is a separation method based on differential migration of analytes in electric fields. The compatibility with purely aqueous separation media makes it a versatile tool in metallodrug research. Many metallodrugs undergo ligand exchange reactions that can easily be followed with this method and the information gained can even be improved by coupling the CE to advanced detectors, such as mass spectrometers. This gives the method high potential to facilitate the development of metallodrugs, especially when combined with innovative method development and experimental design.
authors.affiliation: University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland 1142, New Zealand.
authors.forename: Hannah
authors.initials: H
authors.lastname: Holtkamp
authors.affiliation: University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland 1142, New Zealand. Electronic address: c.hartinger@auckland.ac.nz.
authors.forename: Christian G
authors.initials: CG
authors.lastname: Hartinger
mesh_terms: D000818:Animals; D056831:Coordination Complexes / Q000032:analysis* / Q000737:chemistry*; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D019075:Electrophoresis, Capillary / Q000379:methods; D006801:Humans
chemical_list: D056831:Coordination Complexes