title: Molecular signatures of mesenchymal stem cell-derived extracellular vesicle-mediated tissue repair.
abstract: Extracellular vesicles (EVs) play important roles in intercellular communications via their content molecules, and mimic, at least in part, the roles that are played by their originating cells. Consistent with this notion, an increasing number of reports have suggested that EVs derived from mesenchymal stem cells (MSCs), which are therapeutically beneficial to a wide range of diseases, can serve as drugs to treat multiple diseases. EVs contain a variety of molecules, including proteins, microRNAs, and mRNAs, and are associated with biological processes in a content molecule-dependent manner. In this article, we review the latest reports regarding the therapeutic potential of MSC-EVs by focusing on the underlying molecular mechanisms of their effects. Specifically, we feature the effects of MSC-EVs in terms of their content molecules and of the tissue recovery processes endowed by these molecules.
authors.affiliation: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. tkatsuda@ncc.go.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Katsuda
authors.affiliation: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. tochiya@ncc.go.jp.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ochiya
mesh_terms: D000818:Animals; D000067128:Extracellular Vesicles / Q000737:chemistry* / Q000502:physiology; D005544:Forecasting; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000627:therapeutic use; D013812:Therapeutics
chemical_list: D012313:RNA