title: Supported Lipid Bilayers for the Generation of Dynamic Cell-Material Interfaces.
abstract: Supported lipid bilayers (SLB) offer unique possibilities for studying cellular membranes and have been used as a synthetic architecture to interact with cells. Here, the state-of-the-art in SLB-based technology is presented. The fabrication, analysis, characteristics and modification of SLBs are described in great detail. Numerous strategies to form SLBs on different substrates, and the means to patteren them, are described. The use of SLBs as model membranes for the study of membrane organization and membrane processes in vitro is highlighted. In addition, the use of SLBs as a substratum for cell analysis is presented, with discrimination between cell-cell and cell-extracellular matrix (ECM) mimicry. The study is concluded with a discussion of the potential for in vivo applications of SLBs.
authors.affiliation: Bioinspired Molecular Engineering, University of Twente, PO Box 217, 7500, AE, Enschede, The Netherlands.|Dept. of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500, AE, Enschede, The Netherlands.|Molecular Nanofabrication Group, MESA+, University of Twente, Enschede, 7500, AE, The Netherlands.
authors.forename: Jasper
authors.initials: J
authors.lastname: van Weerd
authors.affiliation: Dept. of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500, AE, Enschede, The Netherlands.
authors.forename: Marcel
authors.initials: M
authors.lastname: Karperien
authors.affiliation: Bioinspired Molecular Engineering, University of Twente, PO Box 217, 7500, AE, Enschede, The Netherlands.|Molecular Nanofabrication Group, MESA+, University of Twente, Enschede, 7500, AE, The Netherlands.
authors.forename: Pascal
authors.initials: P
authors.lastname: Jonkheijm
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002477:Cells / Q000187:drug effects / Q000378:metabolism*; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D008567:Membranes, Artificial
chemical_list: D001672:Biocompatible Materials; D008051:Lipid Bilayers; D008567:Membranes, Artificial
keywords: biomimicry; cell interfaces; cell-cell contacts; cell-extracellular matrix contacts; supported lipid bilayers