title: [Lactose intolerance: past and present. Part 1].
abstract: Lactose intolerance is the most prevalent intestinal malabsorption disorder. After presentation of its history, the author describes the emergence of lactose intolerance during the evolution of species, and the biochemistry of lactose as well as features of human and bacterial lactase enzymes are then described. The unequal distribution of lactose intolerance in different continents and population is discussed, followed by presentation of past and present prevalence data in Hungary. Adult-type hypolactasia is caused by a polymorphism of the MCM6 gene located upstream from the lactase gene on the long arm of the chromosome 2. It can be determined with the polymerase chain reaction. The intestinal symptoms of lactose intolerance are well known, but its extra-intestinal manifestations are less recognised. Invasive diagnostic methods (determination of lactase activity from small intestinal biopsies, lactose tolerance test), are accurate, but have been replaced by the non-invasive methods; their gold standard is the H2 breath test. Genetic testing is being used more and more frequently in Hungary too, and, presumably, the methane breath test will be also available in the near future. Lactose intolerance can be accompanied by inflammatory bowel diseases, coeliac disease and irritable bowel syndrome; it could be established whether this association is causal or not in order to start a correct diet and therapy.
authors.affiliation: Ferencvárosi Egészségügyi Szolgáltató Kiemelten Közhasznú Nonprofit Kft. Budapest, Mester u. 45., 1095.
authors.forename: György Miklós
authors.initials: GM
authors.lastname: Buzás
mesh_terms: D000818:Animals; D001706:Biopsy; D001944:Breath Tests; D002446:Celiac Disease / Q000209:etiology; D005060:Europe; D005820:Genetic Testing; D014943:Global Health; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049690:History, Ancient; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015212:Inflammatory Bowel Diseases / Q000209:etiology; D007413:Intestinal Mucosa / Q000378:metabolism; D043183:Irritable Bowel Syndrome / Q000209:etiology; D043322:Lactase / Q000172:deficiency; D007785:Lactose / Q000737:chemistry / Q000378:metabolism*; D007787:Lactose Intolerance / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000266:history; D007789:Lactose Tolerance Test; D008697:Methane / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence
chemical_list: D043322:Lactase; D007785:Lactose; D008697:Methane
keywords: coeliac disease; coeliakia; gyulladásos bélbetegség; inflammatory bowel disease; irritable bowel syndrome; irritábilis bél; lactase; lactose; lactose intolerance; laktáz; laktóz; polimorfizmus; polymorphism; tejcukor-érzékenység