title: [Psychopathological Profiles of Offspring of Subjects with Bipolar Disorder].
abstract: BACKGROUND
  Bipolar Disorder (BD) has a high heritability and is more prevalent in first-degree relatives with family history. This makes the bipolar offspring (BO) an ideal study group to evaluate the natural history and the prodromal symptoms of this disorder. The main psychopathological findings for this group in various studies are described in this review.
  
  
  METHODS
  Articles comparing the psychopathology of bipolar offspring to either the offspring of other psychiatric patients or the offspring of healthy controls were reviewed.
  
  
  RESULTS
  The reviewed studies showed that the BO group had higher rates of affective disorders when compared to the offspring of other psychiatric patients or the offspring of healthy controls. The high prevalence of anxiety disorders, ADHD, and disruptive behavior disorders in this population suggest that such disorders could be considered prodromes of mood disorders.
  
  
  CONCLUSIONS
  The group of BO had a significantly higher risk of developing a wide range of psychiatric disorders besides BD. More longitudinal studies are needed to characterize this population at risk for BD and to elucidate the risk factors in the progression of this disorder.
authors.affiliation: Médico(a) residente de II año de Psiquiatría, Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Esteban Uribe
authors.initials: EU
authors.lastname: Villa
authors.affiliation: Médico(a) residente de II año de Psiquiatría, Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Paola Gutiérrez
authors.initials: PG
authors.lastname: Briceño
authors.affiliation: Médico. MSc. Psiquiatra de niños y adolescentes. Profesor asociado, Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Juan David
authors.initials: JD
authors.lastname: Palacio
authors.affiliation: Médica psiquiatra. MSc. PhD en Epidemiología. Profesora asociada, Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Electronic address: tdahcartagena@gmail.com.
authors.forename: Jenny
authors.initials: J
authors.lastname: García
keywords: Bipolar disorder; Trastorno bipolar; psicopatología; psychopathology; temperament; temperamento