title: Influence of Fatty Liver on the Severity and Clinical Outcome in Acute Pancreatitis.
abstract: Acute pancreatitis (AP) is a common disease in the department of gastroenterology with variable severity, from being mild and self-limited to severe and fatal. The early diagnosis and accurate prediction of AP severity are of great importance. Our primary observation showed that fatty liver (FL) was frequently detected in patients with AP. In this retrospective study, we aimed to evaluate the relation between FL and the severity and outcomes of AP. The medical records of 2671 patients with AP were reviewed retrospectively, and characteristics of AP patients were recorded. FL was assessed by abdominal CT scan, and AP patients were categorized by the occurrence of FL for the analysis. The variation of mortality, clinical severity and the appearance of CT were analyzed between the non-FL group and FL groups. Compared with patients without FL, an obviously higher rate of death and higher frequency of severe AP (SAP) and necrotizing AP (ANP) were observed in patients with FL, as well as the incidence of local complications and systemic complications. Taking obesity into consideration, a higher rate of death and more severe AP were found in patients with FL, no matter whether they were obese or not. Alcoholic fatty liver (AFL) and non-alcoholic fatty liver (NAFL) were also separated for comparison in this study; the incidence of ANP and the clinical severity had no significant difference between the AFL and NAFL groups. In conclusion, FL could influence the severity and clinical outcome and may play a prognostic role in AP. This study is of clinical significance, because few reports have been previously issued on FL and AP.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Affiliated Wujiang Hospital of Nantong University, Jiangsu, China.
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Qiao
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, China.
authors.forename: Yongda
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, China.
authors.forename: Deqing
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhuang
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Xing
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Jiangsu, China.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D005234:Fatty Liver / Q000150:complications* / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D016017:Odds Ratio; D010195:Pancreatitis / Q000150:complications* / Q000401:mortality; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications* / Q000401:mortality; D011379:Prognosis; D011860:Radiography, Abdominal; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed