title: Transfer of humoural immunity over two generations in urban pigeons.
abstract: Maternal antibodies (MatAb) are known to provide passive protection early in life for young vertebrates but their effects on the development of offspring immune response across generations are still unknown. Here, we investigated the effects of antigen exposure (keyhole limpet haemocyanin, KLH) experienced by urban pigeon (Columba livia) females on the amount of antigen-specific antibodies (Abs) transferred into the egg yolk of their daughters and on the humoural immune response towards this same antigen in their grandchildren. We found that chicks from KLH-injected maternal grandmothers had a higher humoural response than chicks from sham-injected grandmothers. However, we did not detect a significant effect of female KLH exposure on the ability of their daughters to transmit anti-KLH Abs into their eggs. These results suggest that antigen exposure at one generation may shape the immune profile of offspring over two next generations, although the underlying mechanisms remain to be investigated.
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UPEC, Paris 7, CNRS, INRA, IRD, Institut d'Ecologie et des Sciences de l'Environnement de, Paris, F-75005, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Ismail
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UPEC, Paris 7, CNRS, INRA, IRD, Institut d'Ecologie et des Sciences de l'Environnement de, Paris, F-75005, Paris, France CNRS, ENFA, UMR 5174 EDB (Laboratoire Évolution & Diversité Biologique), Université Toulouse 3 Paul Sabatier, Toulouse 31062, France.
authors.forename: L
authors.initials: L
authors.lastname: Jacquin
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UPEC, Paris 7, CNRS, INRA, IRD, Institut d'Ecologie et des Sciences de l'Environnement de, Paris, F-75005, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Haussy
authors.affiliation: Centre d'Ecologie Expérimentale et Prédictive CEREEP-Ecotron Ile-De-France CNRS ENS, UMS 3194, Ecole Normale Supérieure, St-Pierre-lès-Nemours, France.
authors.forename: S
authors.initials: S
authors.lastname: Perret
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UPEC, Paris 7, CNRS, INRA, IRD, Institut d'Ecologie et des Sciences de l'Environnement de, Paris, F-75005, Paris, France julien.gasparini@upmc.fr.
authors.forename: J
authors.initials: J
authors.lastname: Gasparini
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D010856:Columbidae / Q000254:growth & development / Q000276:immunology*; D004530:Egg Yolk / Q000276:immunology; D005260:Female; D006433:Hemocyanins / Q000276:immunology / Q000494:pharmacology; D056724:Immunity, Humoral; D008297:Male
chemical_list: D000906:Antibodies; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin
keywords: grand-maternal effects; immune response; maternal antibodies