title: Progenitor cells may aid successful islet compensation in metabolically healthy obese individuals.
abstract: Obesity is associated with insulin resistance and type 2 diabetes. Fortunately most obese, insulin-resistant individuals do not develop type 2 diabetes as they can overcome reduced efficiency of insulin action by increasing the functional β-cell mass. Compelling evidences suggest β-cells neogenesis through progenitor/stem cells residing in pancreatic ductal cells and islets, but the role of β-cell regeneration in obesity/insulin resistance from progenitor/stem cells is not clear. Based on many indirect evidences in human studies such as unchanged β-cell replication, apoptosis and size during compensation in insulin resistance in humans, we suggest successful β-cells mass compensation in metabolically healthy obesity is contributed by neoformation of β-cells, through expansion of progenitor cells/stem cells in synergy with β-cell replication.
authors.affiliation: Biochemistry/Stem Cell Research, National Institute of Nutrition (ICMR), Tarnaka, Hyderabad, Andhra Pradesh, India. Electronic address: himadrisrmc@gmail.com.
authors.forename: Himadri
authors.initials: H
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, Sri BM Patil Medical College Hospital and Research Centre, BLDE University, Bijapur, Karnataka, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Parthasarathy
authors.affiliation: Institute of Liver Disease and Transplantation, Global Health City, Chennai, India.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Farouk
authors.affiliation: Biochemistry/Stem Cell Research, National Institute of Nutrition (ICMR), Tarnaka, Hyderabad, Andhra Pradesh, India. Electronic address: V.venkateshan@gmail.com.
authors.forename: Vijayalakshmi
authors.initials: V
authors.lastname: Venkatesan
mesh_terms: D000222:Adaptation, Physiological; D017209:Apoptosis; D002450:Cell Communication; D002454:Cell Differentiation; D049109:Cell Proliferation; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000473:pathology*; D008659:Metabolic Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism / Q000473:pathology*; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology*
chemical_list: D007328:Insulin