title: Mazabraud's syndrome: Report of its first incidence in the Middle East and a literature review.
abstract: BACKGROUND
  Mazabraud's syndrome, a rare benign disease with indolent course, is best described as an association between soft tissue myxoma and fibrous dysplasia of the bones. In this report, we describe the first case of this syndrome from Saudi Arabia.
  
  
  METHODS
  A 24-year-old male in overall good health status, presented with progressive left knee swelling over 6 years with no other associated symptoms. The swelling measured 5 cm in diameter, with smooth surface, and soft palpable texture. Radiological examination followed by histopathological examination of the excised mass confirmed our diagnosis of Mazabraud's syndrome. The patient was closely followed up with systematic examination with no recurrence.
  
  
  CONCLUSIONS
  Fibrous dysplasia, soft tissue myxoma and multiple endocrinological diseases like McCune-Albright syndrome characterize Mazabraud's syndrome. Furthermore, fibrous dysplasia is found to be associated with GNA1S gene mutation. Many patients can have asymptomatic course of the disease but may present with pathological fractures, pain, and limitation of movement when the myxoma is near the joints or just simple cosmetically disturbing swelling like in our case.
  
  
  CONCLUSIONS
  Patients with such presentation need to be investigated thoroughly to rule out associated diseases and to evaluate the extent of such pathology. The improvement of radiological modalities can help in narrowing the differential diagnosis and following the patient to early detect the recurrence or any malignant transformation of the condition.
authors.affiliation: King Abdulaziz Medical City, Riyadh, Saudi Arabia.
authors.forename: Abdulaziz Khalid
authors.initials: AK
authors.lastname: Alhujayri
authors.affiliation: King Saud University/College of Medicine, King Khalid University Hospital, Saudi Arabia.
authors.forename: Feras
authors.initials: F
authors.lastname: AlShomer
authors.affiliation: King Abdulaziz Medical City, Riyadh, Saudi Arabia.
authors.forename: Rayan
authors.initials: R
authors.lastname: Alalola
authors.affiliation: Security Forces Hospital, Riyadh, Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alqahtani
authors.affiliation: King Saud University/College of Medicine, King Khalid University Hospital, Saudi Arabia.
authors.forename: Bisher
authors.initials: B
authors.lastname: Alshanawani
keywords: Fibrous dysplasia; Mazabraud; Myxoma