title: Effect of lung resection on pleuro-pulmonary mechanics and fluid balance.
abstract: The aim of the study was to determine in human patients the effect of lung resection on lung compliance and on pleuro-pulmonary fluid balance. Pre and post-operative values of compliance were measured in anesthetized patients undergoing resection for lung cancer (N=11) through double-lumen bronchial intubation. Lung compliance was measured for 10-12 cm H2O increase in alveolar pressure from 5 cm H2O PEEP in control and repeated after resection. No air leak was assessed and pleural fluid was collected during hospital stay. A significant negative correlation (r(2)=0.68) was found between compliance at 10 min and resected mass. Based on the pre-operative estimated lung weight, the decrease in compliance following lung resection exceeded by 10-15% that expected from resected mass. Significant negative relationships were found by relating pleural fluid drainage flow to the remaining lung mass and to post-operative lung compliance. Following lung re-expansion, data suggest a causative relationship between the decrease in compliance and the perturbation in pleuro-pulmonary fluid balance.
authors.affiliation: Dipartimento di Ingegneria Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy. Electronic address: caterina.salito@polimi.it.
authors.forename: C
authors.initials: C
authors.lastname: Salito
authors.affiliation: Dipartimento di Ingegneria Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Bovio
authors.affiliation: Section of Minimally Invasive Thoracic Surgery, Division of Thoracic Surgery, Ospedali Riuniti Ancona, Ancona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Orsetti
authors.affiliation: Section of Minimally Invasive Thoracic Surgery, Division of Thoracic Surgery, Ospedali Riuniti Ancona, Ancona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Salati
authors.affiliation: Department of Thoracic Surgery, St. James's University Hospital, Leeds, UK.
authors.forename: A
authors.initials: A
authors.lastname: Brunelli
authors.affiliation: Dipartimento di Ingegneria Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Aliverti
authors.affiliation: Dipartimento di Scienze della Salute, Università degli Studi di Milano-Bicocca, Monza, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Miserocchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008168:Lung / Q000601:surgery*; D008170:Lung Compliance; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010994:Pleura / Q000473:pathology / Q000503:physiopathology*; D011175:Positive-Pressure Respiration; D015656:Respiratory Mechanics / Q000502:physiology*; D013223:Statistics as Topic; D014882:Water-Electrolyte Balance / Q000502:physiology*