title: Anaphylaxis to Intravenous Tramadol in a Child.
abstract: Hypersensitivity reactions to tramadol are rare and the drug is commonly considered safe. Here, we report the first case of anaphylaxis to tramadol in a child. We point out the difficulty in reaching a confident diagnosis when testing opioid alkaloid drugs with histamine-releasing properties. Additionally, we showed the importance of a well-performed allergy work-up, especially when testing drugs with low experience and when standardized concentrations have not been tested. Moreover, this case provides insight into the possibility of severe reactions, and even anaphylaxis, to tramadol.
authors.affiliation: Allergy Unit, Department of Paediatrics, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Mori
authors.forename: Simona
authors.initials: S
authors.lastname: Barni
authors.forename: Mariangela
authors.initials: M
authors.lastname: Manfredi
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Sarti
authors.forename: Lisa
authors.initials: L
authors.lastname: Pecorari
authors.forename: Neri
authors.initials: N
authors.lastname: Pucci
authors.forename: Elio
authors.initials: E
authors.lastname: Novembre
mesh_terms: D000293:Adolescent; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007275:Injections, Intravenous; D007428:Intradermal Tests; D008297:Male; D014147:Tramadol / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000701:Analgesics, Opioid; D007073:Immunoglobulin E; D014147:Tramadol