title: Distance-of-Flight Mass Spectrometry with IonCCD Detection and an Inductively Coupled Plasma Source.
abstract: Distance-of-flight mass spectrometry (DOFMS) is demonstrated for the first time with a commercially available ion detector-the IonCCD camera. Because DOFMS is a velocity-based MS technique that provides spatially dispersive, simultaneous mass spectrometry, a position-sensitive ion detector is needed for mass-spectral collection. The IonCCD camera is a 5.1-cm long, 1-D array that is capable of simultaneous, multichannel ion detection along a focal plane, which makes it an attractive option for DOFMS. In the current study, the IonCCD camera is evaluated for DOFMS with an inductively coupled plasma (ICP) ionization source over a relatively short field-free mass-separation distance of 25.3-30.4 cm. The combination of ICP-DOFMS and the IonCCD detector results in a mass-spectral resolving power (FWHM) of approximately 900 and isotope-ratio precision equivalent to or slightly better than current ICP-TOFMS systems. The measured isotope-ratio precision in % relative standard deviation (%RSD) was ≥0.008%RSD for nonconsecutive isotopes at 10-ppm concentration (near the ion-signal saturation point) and ≥0.02%RSD for all isotopes at 1-ppm. Results of DOFMS with the IonCCD camera are also compared with those of two previously characterized detection setups.
authors.affiliation: Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA.
authors.forename: Elise A
authors.initials: EA
authors.lastname: Dennis
authors.affiliation: Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Ray
authors.affiliation: Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM, 87131, USA.
authors.forename: Christie G
authors.initials: CG
authors.lastname: Enke
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, 8093, Zurich, Switzerland.
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Gundlach-Graham
authors.affiliation: Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Barinaga
authors.affiliation: Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Koppenaal
authors.affiliation: Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA. hieftje@indiana.edu.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Hieftje
keywords: Distance-of-flight; Inductively coupled plasma; Instrumentation; IonCCD camera