title: Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides.
abstract: The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control.
authors.affiliation: Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, 78464 Konstanz, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Prestel
authors.affiliation: Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, 78464 Konstanz, Germany and Institute of Chemistry/Analytical Chemistry, University of Potsdam, 14476 Potsdam, Germany. heiko.moeller@uni-potsdam.de.
authors.forename: Heiko M
authors.initials: HM
authors.lastname: Möller
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D004705:Endocytosis; D006801:Humans; D015394:Molecular Structure; D021381:Protein Transport
chemical_list: D001391:Azo Compounds; D057846:Cell-Penetrating Peptides; C009850:azobenzene