title: Drug sensitivity testing platforms for gastric cancer diagnostics.
abstract: Gastric cancer diagnostics has traditionally been histomorphological and primarily the domain of surgical pathologists. Although there is an increasing usage of molecular and genomic techniques for clinical diagnostics, there is an emerging field of personalised drug sensitivity testing. In this review, we describe the various personalised drug sensitivity testing platforms and discuss the challenges facing clinical adoption of these assays for gastric cancer.
authors.affiliation: Department of Gastroenterology Monash University, Melbourne, Australia.
authors.forename: Vianne
authors.initials: V
authors.lastname: Lau
authors.affiliation: Department of Haematology and Oncology, National University Health System, Singapore, Singapore.
authors.forename: Andrea Li-Ann
authors.initials: AL
authors.lastname: Wong
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore Department of Laboratory Medicine, Molecular Diagnosis Centre, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Christopher
authors.initials: C
authors.lastname: Ng
authors.affiliation: Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Yingting
authors.initials: Y
authors.lastname: Mok
authors.affiliation: Mouse Models for Human Cancer Unit, Institute of Molecular and Cell Biology, Singapore, Singapore.
authors.forename: Manikandan
authors.initials: M
authors.lastname: Lakshmanan
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore Department of Laboratory Medicine, Molecular Diagnosis Centre, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Benedict
authors.initials: B
authors.lastname: Yan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice; D025202:Molecular Diagnostic Techniques; D058990:Molecular Targeted Therapy; D009360:Neoplastic Cells, Circulating / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010641:Phenotype; D057285:Precision Medicine / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D015398:Signal Transduction / Q000187:drug effects; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
keywords: CHEMOTHERAPY; CIRCULATING TUMOUR CELLS; GASTRIC CANCER