title: Novel Prognostic Markers Derived from Cardiovascular Magnetic Resonance Imaging in Patients with Stable Chronic Coronary Artery Disease.
abstract: BACKGROUND
  In patients with coronary artery disease (CAD), risk stratification remains a challenge. Recently, epicardial adipose tissue (EAT) assessed by cardiovascular magnetic resonance imaging (CMRI) has emerged as a new marker in patients with CAD. Thus, we aimed to investigate the association of CMR parameters with all-cause and cardiac mortality in patients with CAD.
  
  
  METHODS
  CMRI examination was performed in 260 patients with CAD.
  
  
  RESULTS
  In the 40 patients who died, left ventricular (LV) ejection fraction, right ventricular fractioning shortening, LV remodeling index and indexed EAT were significantly reduced, whereas LV mass index, LV end-diastolic volume index, LV end-systolic volume index, LV end-diastolic diameter and the extent of late gadolinium enhancement expressed as a percentage of the maximum possible score to estimate the extent of LGE relative to LV mass (LGE %), were significantly elevated. Using multivariate analysis, age, LV mass index, extent of LGE % and indexed EAT proved to be independently associated with all-cause and cardiac mortality.
  
  
  CONCLUSIONS
  Age, LV mass index, the extent of LGE % and indexed EAT are independent predictors of mortality that might contribute to a more accurate risk stratification of patients with CAD.
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany German Centre for Cardiovascular Research partner site, Mannheim, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Doesch
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Jochims
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany German Centre for Cardiovascular Research partner site, Mannheim, Germany Florian.Streitner@umm.de.
authors.forename: Florian
authors.initials: F
authors.lastname: Streitner
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany German Centre for Cardiovascular Research partner site, Mannheim, Germany.
authors.forename: Juergen
authors.initials: J
authors.lastname: Kuschyk
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany German Centre for Cardiovascular Research partner site, Mannheim, Germany.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Akin
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany German Centre for Cardiovascular Research partner site, Mannheim, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Lehmann
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany German Centre for Cardiovascular Research partner site, Mannheim, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Lossnitzer
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany German Centre for Cardiovascular Research partner site, Mannheim, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Behnes
authors.affiliation: German Centre for Cardiovascular Research partner site, Mannheim, Germany Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany German Centre for Cardiovascular Research partner site, Mannheim, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Borggrefe
authors.affiliation: First Department of Medicine, Cardiology affiliated at the DZHK (German Centre for Cardiovascular Research), University Medical Centre Mannheim, Mannheim, Germany German Centre for Cardiovascular Research partner site, Mannheim, Germany.
authors.forename: Theano
authors.initials: T
authors.lastname: Papavassiliu
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000473:pathology; D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D056149:Epicardial Mapping; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D005682:Gadolinium
keywords: Epicardial adipose tissue; extent of late gamolinium enhancement; left ventricular mass index; prognostic markers; stable coronary artery disease