title: Targeting CD8 T-Cell Metabolism in Transplantation.
abstract: Infiltration of effector CD8 T cells plays a major role in allograft rejection, and increases in memory and terminally differentiated effector memory CD8 T cells are associated with long-term allograft dysfunction. Alternatively, CD8 regulatory T cells suppress the inflammatory responses of effector lymphocytes and induce allograft tolerance in animal models. Recently, there has been a renewed interest in the field of immunometabolics and its important role in CD8 function and differentiation. The purpose of this review is to highlight the key metabolic pathways involved in CD8 T cells and to discuss how manipulating these metabolic pathways could lead to new immunosuppressive strategies for the transplantation field.
authors.affiliation: UMR 1064, INSERM , Nantes , France ; Faculté de Médecine, Université de Nantes , Nantes , France.
authors.forename: Michelle
authors.initials: M
authors.lastname: Yap
authors.affiliation: UMR 1064, INSERM , Nantes , France ; CHU de Nantes, ITUN , Nantes , France ; CIC Biothérapie , Nantes , France ; CHU Nantes, CRB , Nantes , France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Brouard
authors.affiliation: Faculté de Médecine, Université de Nantes , Nantes , France ; UMR 892, INSERM , Nantes , France.
authors.forename: Claire
authors.initials: C
authors.lastname: Pecqueur
authors.affiliation: UMR 1064, INSERM , Nantes , France ; CHU de Nantes, ITUN , Nantes , France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Degauque
keywords: CD8 lymphocytes; glycolysis; metabolism; mitochondria; regulation; therapeutics; transplantation