title: Pathological-Condition-Driven Construction of Supramolecular Nanoassemblies for Bacterial Infection Detection.
abstract: A pyropheophorbide-α-based building block (Ppa-PLGVRG-Van) can be used to construct self-aggregated superstructures in vivo for highly specific and sensitive diagnosis of bacterial infection by noninvasive photoacoustic tomography. This in vivo supramolecular chemistry approach opens a new avenue for efficient, rapid, and early-stage disease diagnosis with high sensitivity and specificity.
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Li
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Huai-Lei
authors.initials: HL
authors.lastname: Ma
authors.affiliation: Key Lab for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 693 Xiongchu Ave, Wuhan, 430073, China.
authors.forename: Guo-Bin
authors.initials: GB
authors.lastname: Qi
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Key Lab for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 693 Xiongchu Ave, Wuhan, 430073, China.
authors.forename: Faquan
authors.initials: F
authors.lastname: Yu
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.|Yangtze River Delta Academy of Nanotechnology and Industry Development Research, Jiaxing, 314000, China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D004195:Disease Models, Animal; D004926:Escherichia coli; D018093:Gelatinases / Q000737:chemistry; D051379:Mice; D008954:Models, Biological; D015394:Molecular Structure; D009220:Myositis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D049329:Nanostructures / Q000737:chemistry; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D011514:Proteus vulgaris; D013211:Staphylococcus aureus; D013212:Staphylococcus epidermidis; D014054:Tomography / Q000379:methods*; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D003287:Contrast Media; C000611540:Ppa-PLGVRG-Van; D014867:Water; D002734:Chlorophyll; C040298:pyropheophorbide a; D014640:Vancomycin; D018093:Gelatinases
keywords: bacterial infection; bioimaging; nanomaterials; peptides; supramolecular