title: Crosstalk between transforming growth factor-β signaling pathway and long non-coding RNAs in cancer.
abstract: The transforming growth factor-β (TGF-β) signaling pathway plays an important role in tumorigenesis by exerting either a tumor-suppressing or tumor-promoting effect. Long non-coding RNAs (lncRNAs), a newly discovered class of non-coding RNAs, have been widely studied in recent years and identified as crucial regulators of various biological processes, including cell cycle progression, chromatin remodeling, gene transcription, and posttranscriptional processing. Recent evidence, addressing the crosstalk between the TGF-β signaling pathway and lncRNAs in cancer, found that several members of the TGF-β pathway are targeted by lncRNAs, and the production of hundreds of lncRNAs is induced by TGF-β treatment. This review will summarize the latest progress on the investigation of TGF-β pathway and lncRNA network in regulating cancer development. Further study on the network would provide a better understanding of carcinogenesis and have potentials for the prevention and treatment of malignant diseases.
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Na
authors.initials: N
authors.lastname: Shao
authors.affiliation: Department of Breast Tumor Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Bingxu
authors.initials: B
authors.lastname: Tan
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Qingxu
authors.initials: Q
authors.lastname: Song
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, Jinan, China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Ling
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, Jinan, China. Electronic address: qlcyf1965@163.com.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D062085:RNA, Long Noncoding / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: D062085:RNA, Long Noncoding; D016212:Transforming Growth Factor beta; D025521:Tumor Suppressor Proteins
keywords: Cancer; Long non-coding RNAs; Transforming growth factor-β