title: Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?
abstract: Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connecting mechanism, however, is not completely known. This review is focused on: (1) iron deficiency in obese children and the role of hepcidin in the connection between body fat and poor iron status; (2) iron status and consequences on health, in particular on cognitive function; (3) cognitive function and obesity; (4) suggestion of a possible link between cognitive dysfunction and ID in pediatric obesity; and implications for therapy and future research.
authors.affiliation: Department of Woman, Child, General and Specialized Surgery, Second University of Naples Via De Crecchio 2-4, Naples 80138, Italy. agrandone@gmail.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Grandone
authors.affiliation: Department of Woman, Child, General and Specialized Surgery, Second University of Naples Via De Crecchio 2-4, Naples 80138, Italy. pierluigi.marzuillo@gmail.com.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Marzuillo
authors.affiliation: Department of Woman, Child, General and Specialized Surgery, Second University of Naples Via De Crecchio 2-4, Naples 80138, Italy. laura.perrone@unina2.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Perrone
authors.affiliation: Department of Woman, Child, General and Specialized Surgery, Second University of Naples Via De Crecchio 2-4, Naples 80138, Italy. emanuele.miraglia@unina2.it.
authors.forename: Emanuele Miraglia
authors.initials: EM
authors.lastname: Del Giudice
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000097:blood*; D002648:Child; D003071:Cognition / Q000187:drug effects*; D064451:Hepcidins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D000090463:Iron Deficiencies; D063766:Pediatric Obesity / Q000097:blood*
chemical_list: D064451:Hepcidins; D007501:Iron
keywords: children; cognitive dysfunction; hepcidin; iron deficiency; obesity