title: Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population.
abstract: BACKGROUND
  Plasminogen activator inhibitor -2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD).
  
  
  METHODS
  The aim of the current study was to explore the association between the variants in PAI-2 gene and CAD and its prognoses. The three variants (rs8093048, rs9946657, rs9320032) of the PAI-2 gene were detected in 407 patients with CAD and 518 control subjects. All patients with CAD underwent one-year follow-up for major adverse cardiac events (MACE).
  
  
  RESULTS
  The frequencies of the TT genotype and T allele of rs8093048 was significantly higher in CAD patients than that in control subjects (7.6% vs.3.5%, P = 0.003, 28.1 % vs.21.7%, P < 0.001, respectively). Multifactor logistic regression analysis showed that the TT genotype of rs8093048 was a risk factor for CAD (OR = 1.455, 95 % CI: 1.069-1.980, P = 0.017). In addition, the follow-up data showed that CAD patients with rs8093048 TT genotype had significantly higher rate of refractory angina and MACE than those with CC or CT genotype (P = 0.032, P = 0.009, respectively). Cox regression analysis showed that rs8093048 TT genotype was the risk factor for the MACE (Hazard ratio = 5.672, 95% CI = 1.992-16.152, P = 0.001).
  
  
  CONCLUSIONS
  We firstly found that the variant of PAI-2 gene was associated with CAD and recurrent coronary event risk in Chinese Han population, in Xinjiang.
authors.affiliation: Department of Geriatrics, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, China. 250456230@qq.com.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China. luojunyi3130@126.com.
authors.forename: Jun-Yi
authors.initials: JY
authors.lastname: Luo
authors.affiliation: Department of Geriatrics, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, China. zhangleitangtang@sina.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China. yangyn5126@163.com.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China. 247605749@qq.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, Xinjiang, 830054, China. 604760840@qq.com.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, Xinjiang, 830054, China. 825116852@qq.com.
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China. myt-xj@163.com.
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics* / Q000401:mortality; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017396:Plasminogen Activator Inhibitor 2 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D012307:Risk Factors
chemical_list: D017396:Plasminogen Activator Inhibitor 2