title: Diagnostic characteristics of supplemental laboratory criteria for incomplete Kawasaki disease in children with complete Kawasaki disease.
abstract: OBJECTIVE
  In 2004, the American Heart Association (AHA) had published an algorithm for the diagnosis of incomplete Kawasaki disease (KD). The aim of the present study was to investigate characteristics of supplemental laboratory criteria in this algorithm.
  
  
  METHODS
  We retrospectively examined the medical records of 355 patients with KD who were treated with intravenous immunoglobulin (IVIG) during the acute phase of the disease. Laboratory data were obtained before the initial IVIG administration and up to 10 days after fever onset. In 106 patients, laboratory testing was performed more than twice.
  
  
  RESULTS
  The AHA supplemental laboratory criteria were fulfilled in 90 patients (25.4%), and the frequency of laboratory examination (odds ratio [OR], 1.981; 95% confidence interval [CI], 1.391-2.821; P<0.001) was a significant predictor of it. The fulfillment of AHA supplemental laboratory criteria was significantly associated with refractoriness to the initial IVIG administration (OR, 2.388; 95% CI, 1.182-4.826; P=0.013) and dilatation of coronary arteries (OR, 2.776; 95% CI, 1.519-5.074; P=0.001).
  
  
  CONCLUSIONS
  Repeated laboratory testing increased the rate of fulfillment of the AHA supplemental laboratory criteria in children with KD.
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hyun Ok
authors.initials: HO
authors.lastname: Jun
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jeong Jin
authors.initials: JJ
authors.lastname: Yu
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Kang
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Chang Deok
authors.initials: CD
authors.lastname: Seo
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jae Suk
authors.initials: JS
authors.lastname: Baek
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Young-Hwue
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jae-Kon
authors.initials: JK
authors.lastname: Ko
keywords: Diagnosis of Kawasaki disease; Incomplete Kawasaki disease; Kawasaki disease; Laboratory examinations