title: Pulmonary Artery Pulsatility Index Is Associated With Right Ventricular Failure After Left Ventricular Assist Device Surgery.
abstract: BACKGROUND
  Right ventricular failure (RVF) is a major cause of morbidity and mortality after CF-LVAD implantation. We explored the association of pulmonary artery compliance (PAC), pulmonary artery elastance (PAE), and pulmonary artery pulsatility index (PAPi) in addition to established parameters as preoperative determinants of postoperative RVF after CF-LVAD surgery.
  
  
  RESULTS
  We retrospectively reviewed 132 consecutive CF-LVAD implantations at Tufts Medical Center from 2008 to 2013. Clinical, hemodynamic, and echocardiographic data were studied. RVF was defined as the unplanned need for a right ventricular assist device or inotrope dependence for ≥14 days. Univariate analysis was performed. RVF occurred in 32 of 132 patients (24%). PAC and PAE were not changed, whereas the PAPi was lower among patients with versus without postoperative RVF (1.32 ± 0.46 vs 2.77 ± 1.16; P < .001). RA pressure, RA to pulmonary capillary wedge pressure ratio (RA:PCWP), and RV stroke work index (RVSWI) were also associated with RVF. Using receiver operating characteristic curve-derived cut-points, PAPi < 1.85 provided 94% sensitivity and 81% specificity (C-statistic = 0.942) for identifying RVF and exceeded the predictive value of RA:PCWP, RVSWI, or RA pressure alone.
  
  
  CONCLUSIONS
  PAPi is a simple hemodynamic variable that may help to identify patients at high risk of developing RVF after LVAD implantation.
authors.affiliation: Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Morine
authors.affiliation: Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kiernan
authors.affiliation: Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: Duc Thinh
authors.initials: DT
authors.lastname: Pham
authors.affiliation: Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: Vikram
authors.initials: V
authors.lastname: Paruchuri
authors.affiliation: Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: David
authors.initials: D
authors.lastname: Denofrio
authors.affiliation: Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts. Electronic address: nkapur@tuftsmedicalcenter.org.
authors.forename: Navin K
authors.initials: NK
authors.lastname: Kapur
mesh_terms: D000328:Adult; D000368:Aged; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000517:prevention & control; D006352:Heart Ventricles / Q000601:surgery*; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000503:physiopathology*; D011669:Pulmonary Wedge Pressure; D012372:ROC Curve; D012189:Retrospective Studies; D018497:Ventricular Dysfunction, Right / Q000209:etiology* / Q000517:prevention & control
keywords: Right ventricular failure; hemodynamics; left ventricular assist device