title: Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy.
abstract: Since the identification of PLA2R (M-type phospholipase A2 receptor) as the first human antigenic target in primary membranous nephropathy (MN), perpetual progress has been made in understanding the pathogenesis of this disease. Accumulating clinical data support a pathogenic role for the anti-PLA2R antibodies (PLA2R ABs), but confirmation in an animal model is still lacking. However, PLA2R ABs were related to disease activity and outcome, as well as to response therapy. Accordingly, PLA2R ABs assay seems to be promising tool not only to diagnose MN but also to predict the course of the disease and could open the way to personalize therapy. Nevertheless, validation of a universal assay with high precision and definition of cut-off levels, followed by larger studies with a prolonged follow-up period, are needed to confirm these prospects.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu Street No. 37, District 1, 022328 Bucharest, Romania.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Obrisca
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu Street No. 37, District 1, 022328 Bucharest, Romania ; Center of Internal Medicine-Nephrology, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Gener
authors.initials: G
authors.lastname: Ismail
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu Street No. 37, District 1, 022328 Bucharest, Romania ; Center of Internal Medicine-Nephrology, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Roxana
authors.initials: R
authors.lastname: Jurubita
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu Street No. 37, District 1, 022328 Bucharest, Romania ; Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Catalin
authors.initials: C
authors.lastname: Baston
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu Street No. 37, District 1, 022328 Bucharest, Romania ; Center of Internal Medicine-Nephrology, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania.
authors.forename: Andreea
authors.initials: A
authors.lastname: Andronesi
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu Street No. 37, District 1, 022328 Bucharest, Romania ; "Dr. Carol Davila" Teaching Hospital of Nephrology, Calea Grivitei Street No. 4, District 1, 010731 Bucharest, Romania.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Mircescu
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D019317:Evidence-Based Medicine; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D054507:Receptors, Phospholipase A2 / Q000037:antagonists & inhibitors* / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D054507:Receptors, Phospholipase A2