title: Successful Treatment of Leukemic Mature B-Cell Lymphoid Neoplasm with Similar Features to Splenic Marginal Zone Lymphoma Possessing Aberrant Myeloid Markers.
abstract: In splenic marginal zone lymphoma (SMZL), there are cases that cannot accurately be classified as such because of overlapping morphologic and/or immunophenotypic features. We report here a 76-year-old Japanese female, who showed leukemic B-cell lymphoproliferative disease possessing characteristic features identified for SMZL. The patient was leukemic with white blood cell counts 49,400/µL (abnormal cells, 78.5%) and neoplastic cells were characterized by aberrant expression of myeloid markers with CD19(+)CD13(+) (64.2%) and CD20(+)CD11c(+) (25.1%). Considering her history of previous chemotherapy and systemic leukemic phase of the disease, we treated the patient without performing splenectomy, with successful use of a combination of rituximab/bendamustine hydrochloride and of rituximab/cladribine. The patient has been in a complete remission longer than 44 months, with no detectable M-protein.
authors.affiliation: Division of Hematology, Takasagoseibu Hospital, Takasago 676-0812, Japan.
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Imashuku
authors.affiliation: Division of Hematology, Takasagoseibu Hospital, Takasago 676-0812, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kudo
authors.affiliation: Division of Internal Medicine, Takasagoseibu Hospital, Takasago 676-0812, Japan.
authors.forename: Kagekatsu
authors.initials: K
authors.lastname: Kubo
authors.affiliation: Division of Hematology, Takasagoseibu Hospital, Takasago 676-0812, Japan.
authors.forename: Katsuyasu
authors.initials: K
authors.lastname: Saigo