title: Towards curative therapy in gastric cancer: Faraway, so close!
abstract: Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer (GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments.
authors.affiliation: Marília Cravo, Catarina Fidalgo, Rita Garrido, Tânia Rodrigues, Gonçalo Luz, Carolina Palmela, Marta Santos, Fábio Lopes, Rui Maio, Gastroenterology Department, Surgery and Oncology Clinics, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
authors.forename: Marília
authors.initials: M
authors.lastname: Cravo
authors.affiliation: Marília Cravo, Catarina Fidalgo, Rita Garrido, Tânia Rodrigues, Gonçalo Luz, Carolina Palmela, Marta Santos, Fábio Lopes, Rui Maio, Gastroenterology Department, Surgery and Oncology Clinics, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Fidalgo
authors.affiliation: Marília Cravo, Catarina Fidalgo, Rita Garrido, Tânia Rodrigues, Gonçalo Luz, Carolina Palmela, Marta Santos, Fábio Lopes, Rui Maio, Gastroenterology Department, Surgery and Oncology Clinics, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
authors.forename: Rita
authors.initials: R
authors.lastname: Garrido
authors.affiliation: Marília Cravo, Catarina Fidalgo, Rita Garrido, Tânia Rodrigues, Gonçalo Luz, Carolina Palmela, Marta Santos, Fábio Lopes, Rui Maio, Gastroenterology Department, Surgery and Oncology Clinics, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
authors.forename: Tânia
authors.initials: T
authors.lastname: Rodrigues
authors.affiliation: Marília Cravo, Catarina Fidalgo, Rita Garrido, Tânia Rodrigues, Gonçalo Luz, Carolina Palmela, Marta Santos, Fábio Lopes, Rui Maio, Gastroenterology Department, Surgery and Oncology Clinics, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
authors.forename: Gonçalo
authors.initials: G
authors.lastname: Luz
authors.affiliation: Marília Cravo, Catarina Fidalgo, Rita Garrido, Tânia Rodrigues, Gonçalo Luz, Carolina Palmela, Marta Santos, Fábio Lopes, Rui Maio, Gastroenterology Department, Surgery and Oncology Clinics, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
authors.forename: Carolina
authors.initials: C
authors.lastname: Palmela
authors.affiliation: Marília Cravo, Catarina Fidalgo, Rita Garrido, Tânia Rodrigues, Gonçalo Luz, Carolina Palmela, Marta Santos, Fábio Lopes, Rui Maio, Gastroenterology Department, Surgery and Oncology Clinics, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
authors.forename: Marta
authors.initials: M
authors.lastname: Santos
authors.affiliation: Marília Cravo, Catarina Fidalgo, Rita Garrido, Tânia Rodrigues, Gonçalo Luz, Carolina Palmela, Marta Santos, Fábio Lopes, Rui Maio, Gastroenterology Department, Surgery and Oncology Clinics, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
authors.forename: Fábio
authors.initials: F
authors.lastname: Lopes
authors.affiliation: Marília Cravo, Catarina Fidalgo, Rita Garrido, Tânia Rodrigues, Gonçalo Luz, Carolina Palmela, Marta Santos, Fábio Lopes, Rui Maio, Gastroenterology Department, Surgery and Oncology Clinics, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
authors.forename: Rui
authors.initials: R
authors.lastname: Maio
mesh_terms: D000818:Animals; D059186:Chemoradiotherapy, Adjuvant / Q000009:adverse effects / Q000401:mortality; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005743:Gastrectomy / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D020360:Neoadjuvant Therapy / Q000009:adverse effects / Q000401:mortality; D061206:Neoplasm Micrometastasis; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual; D057285:Precision Medicine; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
keywords: Curative surgery; Gastric cancer; Multidisciplinary treatment; Therapeutic strategies