title: The Potential Role of Inflammation Associated with Interaction between Osteopontin and CD44 in a Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Breast Cancer.
abstract: Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare and fatal cancer-related complication. We herein present a case of PTTM that diagnosed antemortem by lung scintigraphy and pulmonary microvascular cytology. The patient was treated with steroid pulse therapy. Although her symptoms temporarily improved, she died of respiratory failure. An autopsy showed PTTM, and an immunohistochemical analysis revealed the expression of osteopontin and CD44 in macrophages that had migrated into the PTTM lesions. These findings suggest that inflammation associated with the interaction between osteopontin and CD44 may play an important role in PTTM.
authors.affiliation: Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Higashi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Dohi
authors.forename: Naohiro
authors.initials: N
authors.lastname: Uraoka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sentani
authors.forename: Sayuri
authors.initials: S
authors.lastname: Uga
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Sada
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kitagawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hidaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kurisu
authors.forename: Hideya
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Wataru
authors.initials: W
authors.lastname: Yasui
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Kihara
mesh_terms: D000368:Aged; D001344:Autopsy; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism* / Q000473:pathology; D053495:Osteopontin / Q000097:blood*; D057049:Thrombotic Microangiopathies / Q000175:diagnosis / Q000473:pathology*
chemical_list: D053495:Osteopontin