title: Labial salivary gland biopsy for diagnosing immunoglobulin light chain amyloidosis: a retrospective analysis.
abstract: Our goal was to evaluate the usefulness of labial salivary gland (LSG) biopsy for diagnosing immunoglobulin light chain (AL) amyloidosis, by comparing bone marrow and skin biopsies in the same patient population. This retrospective study included 34 consecutive patients who showed evidence of monoclonal proteins and symptoms considered to be due to amyloidosis, and who underwent a tissue biopsy from LSG between January 2005 and December 2012 at Nagoya City University Hospital. All samples of superficial tissues, including LSG, bone marrow, and skin, were independently evaluated as having amyloid deposits by a central review, which was blind to clinical information. An AL amyloidosis diagnosis was based on evidence of amyloid deposition in any biopsied tissue. Eighteen patients were diagnosed with AL amyloidosis. The sensitivity for detecting amyloid deposition was highest in biopsies of LSG at 89 %, followed by 77 % for bone marrow, and 72 % for skin. Amyloid deposition was detected in at least one superficial tissue of all the 18 patients. An LSG biopsy may be appropriate as a first-choice procedure to diagnose AL amyloidosis. Multiple biopsies of superficial tissues, including LSG, bone marrow, and skin, are recommended to increase the sensitivity for diagnosing AL amyloidosis.
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.|Department of Hematology, Toyokawa City Hospital, 23 Noji, Yawata-cho, Toyokawa, 442-8561, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan. skusumot@med.nagoya-cu.ac.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kusumoto
authors.affiliation: Department of Neurology, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto, 860-0811, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Yamashita
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Arisa
authors.initials: A
authors.lastname: Masuda
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Shiori
authors.initials: S
authors.lastname: Kinoshita
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.|Department of Hematology, Toyokawa City Hospital, 23 Noji, Yawata-cho, Toyokawa, 442-8561, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Takami-Mori
authors.affiliation: Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Takino
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Asahi
authors.initials: A
authors.lastname: Ito
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Ri
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Komatsu
authors.affiliation: Department of Neurology, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto, 860-0811, Japan.
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Ueda
authors.affiliation: Department of Neurology, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto, 860-0811, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ando
authors.affiliation: Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inagaki
authors.affiliation: Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Iida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000175:diagnosis* / Q000453:epidemiology; D001706:Biopsy; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D000075363:Immunoglobulin Light-chain Amyloidosis; D007742:Labial Frenum / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012469:Salivary Glands / Q000473:pathology; D012470:Salivary Glands, Minor / Q000473:pathology*; D016037:Single-Blind Method
chemical_list: D007147:Immunoglobulin Light Chains
keywords: AL amyloidosis; Bone marrow; Labial salivary gland; Skin; Superficial tissue biopsy