title: A systematic review of sugammadex vs neostigmine for reversal of neuromuscular blockade.
abstract: We reviewed systematically sugammadex vs neostigmine for reversing neuromuscular blockade. We included 17 randomised controlled trials with 1553 participants. Sugammadex reduced all signs of residual postoperative paralysis, relative risk (95% CI) 0.46 (0.29-0.71), p = 0.0004 and minor respiratory events, relative risk (95% CI) 0.51 (0.32-0.80), p = 0.0034. There was no difference in critical respiratory events, relative risk (95% CI) 0.13 (0.02-1.06), p = 0.06. Sugammadex reduced drug-related side-effects, relative risk (95% CI) 0.72 (0.54-0.95), p = 0.02. There was no difference in the rate of postoperative nausea or the rate of postoperative vomiting, relative risk (95% CI) 0.94 (0.79-1.13), p = 0.53, and 0.87 (0.65-1.17), p = 0.36 respectively.
authors.affiliation: Department of Anaesthesia, Hospital Universitario la Paz, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Abad-Gurumeta
authors.affiliation: Department of Anaesthesia, Complutense University of Madrid, Hospital Universitario Infanta Leonor, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ripollés-Melchor
authors.affiliation: Department of Anaesthesia, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Casans-Francés
authors.affiliation: Department of Anaesthesia, Örebro University Hospital, Örebro, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Espinosa
authors.affiliation: Department of Anaesthesia, Complutense University of Madrid, Hospital Universitario Infanta Leonor, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Hurtado
authors.affiliation: Department of Consultant Preventive Medicine and Public Health, Complutense University of Madrid, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Pérez
authors.affiliation: Department of Colorectal Surgery, University of Zaragoza, Zaragoza, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Ramírez
authors.affiliation: Department of Anaesthesia, Complutense University of Madrid, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: López-Timoneda
authors.affiliation: Department of Anaesthesia, Complutense University of Madrid, Hospital Universitario Infanta Leonor, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Calvo-Vecino
mesh_terms: D006801:Humans; D009388:Neostigmine / Q000494:pharmacology*; D019148:Neuromuscular Blockade; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
chemical_list: D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D009388:Neostigmine