title: Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy.
abstract: OBJECTIVE
  To investigate the effect of low-level laser therapy on bone healing in diabetic rats.
  
  
  METHODS
  Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was performed every 48 h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed.
  
  
  RESULTS
  Low-level laser therapy significantly increased alkaline phosphatase in at seven and 18 days (p<0.001), and improved bone healing at seven (p<0.01), 18 (p<0.05) and 30 (p<0.01) in diabetic animals. In addition, bone healing in irradiated diabetic group was statistically similar to control group at 30 days (p>0.05).
  
  
  CONCLUSIONS
  Low-level laser therapy increased the serum levels of alkaline phosphatase and improved bone healing in alloxan-induced diabetic rats.
authors.affiliation: Universidade Tiradentes, Aracaju, SE, Brazil.
authors.forename: Marismar Fernandes do
authors.initials: MF
authors.lastname: Nascimento
authors.affiliation: Universidade Tiradentes, Aracaju, SE, Brazil.
authors.forename: Bernadeth Moda de
authors.initials: BM
authors.lastname: Almeida
authors.affiliation: UNIT, Aracaju, SE, Brazil.
authors.forename: John Lennon Silva
authors.initials: JL
authors.lastname: Cunha
authors.affiliation: UNIT, Aracaju, SE, Brazil.
authors.forename: Rafael Barreto Vieira
authors.initials: RB
authors.lastname: Valois
authors.affiliation: UNIT, Aracaju, SE, Brazil.
authors.forename: Juliana Campos
authors.initials: JC
authors.lastname: Pinheiro
authors.affiliation: Department of Dentistry, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Maria Amália Gonzaga
authors.initials: MA
authors.lastname: Ribeiro
authors.affiliation: Department of Medicine, UNIT, Aracaju, SE, Brazil.
authors.forename: Sonia Oliveira
authors.initials: SO
authors.lastname: Lima
authors.affiliation: Department of Medicine, UNIT, Aracaju, SE, Brazil.
authors.forename: Ricardo Luiz Cavalcanti de
authors.initials: RL
authors.lastname: Albuquerque-Júnior
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000496:Alloxan; D000818:Animals; D001861:Bone Regeneration / Q000528:radiation effects*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D017102:Fracture Healing / Q000528:radiation effects*; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D010000:Osteitis / Q000473:pathology; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000496:Alloxan; D000469:Alkaline Phosphatase