title: Prostate stem cell antigen variation rs2294008 associated with the risk of bladder cancer.
abstract: Several studies reported Prostate stem cell antigen (PSCA) rs2294008 was susceptibly associated with bladder cancer (BC) risk. However, the results were not entirely consistent. The aim of this study was to investigate the association between rs2294008 and BC risk. Comprehensive meta-analysis was preformed to provide a more precise assessment of the association between rs2294008 and BC risk. Twenty five studies involving 14,244 BC patients and 53,963 controls were included in our meta-analysis. The crude odds ratios (ORs) and the 95% confidence intervals (95% CIs) were used to evaluate the strength of the association. Pooled results indicated that the PSCA variant rs2294008-T was significantly connected with an increased risk of BC (OR = 1.15, 95% CI = 1.12-1.18, P(z) < 0.0001). Moreover, stratified analyses showed that rs2294008 significantly increased BC risk in European (OR = 1.10, 95% CI = 1.05-1.15, P(z) < 0.0001), North American (OR = 1.18, 95% CI = 1.12-1.24, P(z) < 0.0001), and Asian (OR = 1.17, 95% CI = 1.13-1.22, P(z) < 0.0001). In conclusion, our meta-analysis demonstrated that the PSCA rs2294008 is a risk factor for BC in European, Asian and North American. Further large case-control studies are needed to assess the relationship in other populations. Biologically functional studies are needed to verify the molecular mechanisms in the pathogenesis of BC.
authors.affiliation: Department of Urological Surgery, Yinzhou People's Hospital Ningbo 315040, Zhejiang, China.
authors.forename: Maomao
authors.initials: M
authors.lastname: Li
authors.affiliation: Ningbo Medical Center, Lihuili Hospital, Ningbo University Ningbo 315041, Zhejiang, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Urological Surgery, The No. 2 Hospital of Yinzhou Ningbo 315040, Zhejiang, China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University Ningbo 315010, Zhejiang, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Urological Surgery, Yinzhou People's Hospital Ningbo 315040, Zhejiang, China ; Department of Urological Surgery, The No. 2 Hospital of Yinzhou Ningbo 315040, Zhejiang, China.
authors.forename: Guobin
authors.initials: G
authors.lastname: Weng
keywords: Prostate stem cell antigen; bladder cancer; meta-analysis; rs2294008