title: DNA damage response in cisplatin-induced nephrotoxicity.
abstract: Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) are an important pathogenic mechanism of AKI following cisplatin treatment. Activation of DDR may lead to cell cycle arrest and DNA repair for cell survival or, in the presence of severe injury, kidney cell death. Modulation of DDR may provide novel renoprotective strategies for cancer patients undergoing cisplatin chemotherapy.
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Shiyao
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Departments of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
authors.forename: Navjotsingh
authors.initials: N
authors.lastname: Pabla
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Chengyuan
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Liyu
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. zdong@gru.edu.|Department of Cellular Biology and Anatomy, Medical College of Georgia at Georgia Regents University and Charlie Norwood VA Medical Center, 1459 Laney Walker Blvd, Augusta, GA, 30912, USA. zdong@gru.edu.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000493:pharmacokinetics; D002945:Cisplatin / Q000009:adverse effects* / Q000493:pharmacokinetics; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D007684:Kidney Tubules / Q000473:pathology; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: Apoptosis; Cisplatin; DNA damage; Kidney; Nephrotoxicity; P53