title: Role of Vitamin-D in the prevention and treatment of Alzheimer's disease.
abstract: Alzheimer's disease is the most common form of age related cognitive impairment. Aim of the present study was to see the effect of vitamin D on cognitive function in elderly. The study was conducted in Department of Physiology, King George's Medical University (KGMU). A total of 80 subjects were enrolled based on Mini Mental State Examination (MMSE) score < 24 and vitamin D deficiency. They were divided into two groups as Group A (case) and Group B (control), each group having 40 subjects. Intervention (Vitamin D supplementation) was given in Group A. The assessment of dementia was done by Mini Mental State Examination (MMSE) score. Every subject was clinically evaluated and estimation of vitamin D was done by direct ELISA kit. Gender, weight, height, BMI, residence and education were also similar between two groups. A significant (p=0.0001) change in MMSE score was observed in both Group A and Group B from baseline to 3 & 6 months and from 3 to 6 months, however, mean change was higher in Group A than Group B. In conclusion, vitamin D supplementation caused significant improvement in the cognitive performance in subjects with senile dementia.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Gangwar
authors.forename: Anita
authors.initials: A
authors.lastname: Rawat
authors.forename: Sunita
authors.initials: S
authors.lastname: Tiwari
authors.forename: S C
authors.initials: SC
authors.lastname: Tiwari
authors.forename: Jagdish
authors.initials: J
authors.lastname: Narayan
authors.forename: Sanchit
authors.initials: S
authors.lastname: Tiwari
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy / Q000517:prevention & control*; D003071:Cognition; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D014807:Vitamin D