title: [Influence of simulated microgravity on the threshold of pain sensitivity in humans with single dose of ketorolac].
abstract: The data supporting the influence of simulated microgravity effects on pain sensitivity were obtained in the series of experiments involving human. In conditions of antiorthostatic hypokinesia (ANOH) and <<dry>> immersion revealed no reduction in pain sensitivity in the morning, which is typical for normal conditions. Ketorolac has no effect on pain sensitivity, when determining the pain threshold (PT) by method of thermoalgometry. However, the conditions of simulated microgravity substantially alter the pharmacokinetics of ketorolac, increasing the rate of absorption of the drug and reduce its relative bioavailability and retention time in the blood plasma. This may require changes in pain therapy schemes in space flight.
authors.forename: M V
authors.initials: MV
authors.lastname: Baranov
authors.forename: A S
authors.initials: AS
authors.lastname: Kovalev
authors.forename: D F
authors.initials: DF
authors.lastname: Perfilov
authors.forename: R V
authors.initials: RV
authors.lastname: Chernogorov
authors.forename: L G
authors.initials: LG
authors.lastname: Repenkova
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D020910:Ketorolac / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D010146:Pain / Q000097:blood / Q000188:drug therapy*; D014893:Weightlessness
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D020910:Ketorolac