title: An interactomic approach for identification of putative drug targets in Listeria monocytogenes.
abstract: A wide variety of human population is infected with Listeria monocytogenes, which causes listeriosis, a deadly disease with mortality rate of about 30%. The major hindrance to cure listeriosis is the unavailability of specific or selectable drug targets. At present, antibiotics used to cure the disease are not specific and insufficient to manage the disease efficiently. Therefore, in order to search specific drugs, here, we used interactome analysis to search specific drug targets which may provide novel templates for drug designing having better efficacy without any potential adverse effects. The complete genome of L. monocytogenes having 2846 proteins has been analysed. We found 11 proteins as putative drug targets. The sequence and interactome analyses revealed that 11 proteins are non-homologous to human, but essential for pathogen and hence may be considered as potential therapeutic targets.
authors.affiliation: 1 School of Biotechnology, Devi Ahilya University, Khandwa Road, Indore 452001, Madhya Pradesh, India.
authors.forename: Nikita
authors.initials: N
authors.lastname: Chordia
authors.affiliation: 2 School of Biotechnology, Devi Ahilya University, Khandwa Road, Indore 452001, Madhya Pradesh, India.
authors.forename: Nilesh Kumar
authors.initials: NK
authors.lastname: Sharma
authors.affiliation: 3 School of Biotechnology, Devi Ahilya University, Khandwa Road, Indore 452001, Madhya Pradesh, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D023281:Genomics / Q000379:methods*; D006801:Humans; D008089:Listeria monocytogenes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008088:Listeriosis / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Listeria monocytogenes; bioinformatics; cellular localisation; cytoplasmic; drug design; drug targets; interactome analysis; listeriosis; metabolic pathways; non-homologus; potential therapeutic targets; protein sequences; proteins; proteome