title: Preliminary Investigation of Cerebral Blood Flow and Amyloid Burden in Veterans With and Without Combat-Related Traumatic Brain Injury.
abstract: This study aimed to examine global and regional cerebral blood flow and amyloid burden in combat veterans with and without traumatic brain injury (TBI). Cerebral blood flow (in milliliters per minute per 100 mL) was measured by quantitative [(15)O]water, and amyloid burden was measured by [(11)C]PIB imaging. Mean global cerebral blood flow was significantly lower in veterans with TBI compared with non-TBI veterans. There were essentially no differences between groups for globally normalized regional cerebral blood flow. Amyloid burden did not differ between TBI and non-TBI veterans. Veterans who have suffered a TBI have significantly lower cerebral blood flow than non-TBI controls but did not manifest increased levels of amyloid, globally or regionally.
authors.affiliation: From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
authors.forename: Laura L Boles
authors.initials: LL
authors.lastname: Ponto
authors.affiliation: From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Brashers-Krug
authors.affiliation: From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Pierson
authors.affiliation: From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Menda
authors.affiliation: From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
authors.forename: Laura
authors.initials: L
authors.lastname: Acion
authors.affiliation: From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
authors.forename: G Leonard
authors.initials: GL
authors.lastname: Watkins
authors.affiliation: From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
authors.forename: John J
authors.initials: JJ
authors.lastname: Sunderland
authors.affiliation: From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
authors.forename: Julie A
authors.initials: JA
authors.lastname: Koeppel
authors.affiliation: From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ).
authors.forename: Ricardo E
authors.initials: RE
authors.lastname: Jorge
mesh_terms: D000328:Adult; D000682:Amyloid / Q000378:metabolism*; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D000070642:Brain Injuries, Traumatic / Q000378:metabolism / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D008297:Male; D014728:Veterans
chemical_list: D000682:Amyloid