title: The Contribution of Interleukin-10 Promoter Genotypes to Susceptibility to Asthma in Adults.
abstract: OBJECTIVE
  Accumulating evidence suggests that inflammatory processes play a role in asthma etiology, and interleukin-10 (IL10) is an important immunosuppressive cytokine. The present study aimed to evaluate the contribution of IL10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genetic polymorphisms to the risk of asthma in Taiwan.
  
  
  METHODS
  Associations of three IL10 polymorphic genotypes with risk of asthma were investigated among 198 patients with asthma and 453 non-asthmatic healthy controls, by polymerase chain reaction-restriction fragment length polymorphism genotyping method.
  
  
  RESULTS
  The results showed that the percentages of TT, TC and CC for IL-10 T-819C genotypes were differentially represented at 63.1%, 32.3% and 4.6%, respectively, in the patient group and 53.0%, 36.4% and 10.6%, respectively, in the healthy control group (p for trend=0.0114). The CC genotype carriers were at lower risk for asthma (odds ratio=0.36, 95% confidence interval=0.17-0.76, p=0.0055). There was no difference in the distribution of A-1082G or A-592C genotype between the asthma and non-asthma groups. The protective effects of the CC genotype were obvious among males, but not females, and those aged 25 up to 40 years but not those aged over 40 years.
  
  
  CONCLUSIONS
  The CC genotype of IL10 T-819C compared to the TT genotype may have a protective effect on asthma risk in younger adults (25-40 years old), and males in Taiwan.
authors.affiliation: Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Hsia
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Wen-Shin
authors.initials: WS
authors.lastname: Chang
authors.affiliation: Department of Respiratory Medicine, the First Affiliated Hospital of Xi'an Medical University, Xi'an, P.R. China.
authors.forename: Shengyu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Shen
authors.affiliation: Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Wan-Yun
authors.initials: WY
authors.lastname: Hsiao
authors.affiliation: Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Chin-Jung
authors.initials: CJ
authors.lastname: Liu
authors.affiliation: Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Shinn-Jye
authors.initials: SJ
authors.lastname: Liang
authors.affiliation: Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Wei-Chun
authors.initials: WC
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Chih-Yen
authors.initials: CY
authors.lastname: Tu
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Chin-Mu
authors.initials: CM
authors.lastname: Hsu
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com.
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D000328:Adult; D001249:Asthma / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D013624:Taiwan; D055815:Young Adult
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: Age; Taiwan; asthma; gender; genotype; interleukin-10; polymorphism