title: Electrical mapping in bipolar disorder patients during the oddball paradigm.
abstract: Bipolar disorder (BD) is characterized by an alternated occurrence between acute mania episodes and depression or remission moments. The objective of this study is to analyze the information processing changes in BP (Bipolar Patients) (euthymia, depression and mania) during the oddball paradigm, focusing on the P300 component, an electric potential of the cerebral cortex generated in response to external sensorial stimuli, which involves more complex neurophysiological processes related to stimulus interpretation. Twenty-eight bipolar disorder patients (BP) (17 women and 11 men with average age of 32.5, SD: 9.5) and eleven healthy controls (HC) (7 women and 4 men with average age of 29.78, SD: 6.89) were enrolled in this study. The bipolar patients were divided into 3 major groups (i.e., euthymic, depressive and maniac) according to the score on the Clinical Global Impression--Bipolar Version (CGI-BP). The subjects performed the oddball paradigm simultaneously to the EEG record. EEG data were also recorded before and after the execution of the task. A one-way ANOVA was applied to compare the P300 component among the groups. After observing P300 and the subcomponents P3a and P3b, a similarity of amplitude and latency between euthymic and depressive patients was observed, as well as small amplitude in the pre-frontal cortex and reduced P3a response. This can be evidence of impaired information processing, cognitive flexibility, working memory, executive functions and ability to shift the attention and processing to the target and away from distracting stimuli in BD. Such neuropsychological impairments are related to different BD symptoms, which should be known and considered, in order to develop effective clinical treatment strategies.
authors.affiliation: Neurophysiology and Neuropsychology of Attention, Institute of Psychiatry of the Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro - RJ, Brazil. Electronic address: luizadigiorgio@gmail.com.
authors.forename: Luiza Wanick
authors.initials: LW
authors.lastname: Di Giorgio Silva
authors.affiliation: Neurophysiology and Neuropsychology of Attention, Institute of Psychiatry of the Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro - RJ, Brazil.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Cartier
authors.affiliation: Anxiety & Depression Laboratory, Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil.
authors.forename: Elie
authors.initials: E
authors.lastname: Cheniaux
authors.affiliation: Anxiety & Depression Laboratory, Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Novis
authors.affiliation: Anxiety & Depression Laboratory, Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil.
authors.forename: Luciana Angélica
authors.initials: LA
authors.lastname: Silveira
authors.affiliation: Anxiety & Depression Laboratory, Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil.
authors.forename: Paola Anaquim
authors.initials: PA
authors.lastname: Cavaco
authors.affiliation: Anxiety & Depression Laboratory, Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: de Assis da Silva
authors.affiliation: Neurophysiology and Neuropsychology of Attention, Institute of Psychiatry of the Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro - RJ, Brazil.
authors.forename: Washington Adolfo
authors.initials: WA
authors.lastname: Batista
authors.affiliation: Neurophysiology and Neuropsychology of Attention, Institute of Psychiatry of the Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro - RJ, Brazil.
authors.forename: Guaraci Ken
authors.initials: GK
authors.lastname: Tanaka
authors.affiliation: Brain Mapping and Sensory Motor Integration of the Federal University of Rio de Janeiro (UFRJ), Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Gongora
authors.affiliation: Laboratory of Physical therapy - Veiga de Almeida University of Rio de Janeiro (UVA/RJ), Rio de Janeiro, Brazil; Neurophysiology and Neuropsychology of Attention, Institute of Psychiatry of the Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro - RJ, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Bittencourt
authors.affiliation: Brain Mapping and Functionality Laboratory, Federal University of Piauí, Piauí, Brazil.
authors.forename: Silmar
authors.initials: S
authors.lastname: Teixeira
authors.affiliation: Laboratory of Psychophysiology, Faculdade da Saúde, UMESP, São Paulo, Brazil; Division of Neurosurgery, University of São Paulo Medical School, São Paulo, Brazil.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Basile
authors.affiliation: Faculty of Human Sciences, Medical School Hamburg, Hamburg, Germany; Sport Science, Reykjavik University, Reykjavik, Iceland.
authors.forename: Henning
authors.initials: H
authors.lastname: Budde
authors.affiliation: Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Cagy
authors.affiliation: Brain Mapping and Sensory Motor Integration of the Federal University of Rio de Janeiro (UFRJ), Brazil; Bioscience Department, School of Physical Education of the Federal University of Rio de Janeiro (EEFD/UFRJ), Rio de Janeiro, Brazil; Institute of Applied Neuroscience (INA), Rio de Janeiro, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Ribeiro
authors.affiliation: Bioscience Department, School of Physical Education of the Federal University of Rio de Janeiro (EEFD/UFRJ), Rio de Janeiro, Brazil; Institute of Applied Neuroscience (INA), Rio de Janeiro, Brazil; Neurophysiology and Neuropsychology of Attention, Institute of Psychiatry of the Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro - RJ, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: Velasques
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D001714:Bipolar Disorder / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology*; D004569:Electroencephalography; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time
keywords: Bipolar disorder; EEG; Information processing; Neurobiology; P300