title: Helicobacter pylori-negative Differentiated Adenocarcinoma of the Stomach.
abstract: A 58-year-old Japanese man was diagnosed with differentiated adenocarcinoma of the stomach. Histological findings of the resected specimen revealed well- to moderately-differentiated tubular adenocarcinoma (tub1, tub2), 13 mm in diameter, which invaded into the submucosa (SM1, 300 μm) and lymphovascular lumen (ly1). Serum antibody against Helicobacter pylori (Hp) and the (13)C-urea breath test were negative, and there were no atrophic changes in the tumor-adjacent mucosa. The immunohistochemical analysis showed that gastric mucin (MUC5AC) was strongly positive and intestinal mucin (MUC2) was weakly and partially positive. According to these results, the final diagnosis of Hp-negative well-differentiated early gastric cancer was made.
authors.affiliation: Department of Gastroenterology, Nagano Municipal Hospital, Japan.
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Nagaya
authors.forename: Naoki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Yugo
authors.initials: Y
authors.lastname: Iwaya
authors.forename: Yoko
authors.initials: Y
authors.lastname: Jimbo
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Tatai
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ito
authors.forename: Ayako
authors.initials: A
authors.lastname: Seki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Suzawa
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Ochi
authors.forename: Etsuo
authors.initials: E
authors.lastname: Hara
authors.forename: Manabu
authors.initials: M
authors.lastname: Takata
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Otsuki
authors.forename: Mai
authors.initials: M
authors.lastname: Iwaya
authors.forename: Noriko
authors.initials: N
authors.lastname: Hosaka
authors.forename: Norikazu
authors.initials: N
authors.lastname: Arakura
authors.forename: Eiji
authors.initials: E
authors.lastname: Tanaka
authors.forename: Osamu
authors.initials: O
authors.lastname: Hasebe
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D000071616:CDX2 Transcription Factor; D004210:Dissection; D005752:Gastric Mucins / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology*; D005773:Gastroscopy; D016480:Helicobacter pylori; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D055262:Mucin-2 / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D005752:Gastric Mucins; D018398:Homeodomain Proteins; C524625:MUC2 protein, human; D055262:Mucin-2