title: Association of endothelial microparticle with NO, eNOS, ET-1, and fractional flow reserve in patients with coronary intermediate lesions.
abstract: Endothelial microparticle (EMP) is a biomarker for endothelial dysfunction. The aim of this study is to investigate the utility of EMP in evaluating coronary intermediate lesions. Participants included 49 patients with coronary intermediate lesions and 24 subjects with normal coronary arteries. Among these subjects, 28 patients accepted fractional flow reserve (FFR). Results showed that level of EMP was significantly higher in the intermediate lesion group. No correlation was found between EMP and FFR value, suggesting that circulating EMP is a systemic marker rather than a focal one.
authors.affiliation: a Department of Cardiology , Peking University Third Hospital , Beijing , P.R. China .
authors.forename: Rui
authors.initials: R
authors.lastname: Song
authors.affiliation: a Department of Cardiology , Peking University Third Hospital , Beijing , P.R. China .
authors.forename: Yuan I Scarlet
authors.initials: YI
authors.lastname: Chou
authors.affiliation: b The Neuroscience Research Institute & Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University , Beijing , P.R. China , and.
authors.forename: Jinge
authors.initials: J
authors.lastname: Kong
authors.affiliation: c The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center , Beijing , P.R. China.
authors.forename: Jizhao
authors.initials: J
authors.lastname: Li
authors.affiliation: c The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center , Beijing , P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Pan
authors.affiliation: a Department of Cardiology , Peking University Third Hospital , Beijing , P.R. China .
authors.forename: Ming
authors.initials: M
authors.lastname: Cui
authors.affiliation: c The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center , Beijing , P.R. China.
authors.forename: Enchen
authors.initials: E
authors.lastname: Zhou
authors.affiliation: a Department of Cardiology , Peking University Third Hospital , Beijing , P.R. China .
authors.forename: Yongzhen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: c The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center , Beijing , P.R. China.
authors.forename: Lemin
authors.initials: L
authors.lastname: Zheng
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D019332:Endothelin-1 / Q000097:blood / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D052250:Nitric Oxide Synthase Type III / Q000097:blood / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
keywords: Endothelial function; inducible ischemia; intravenous ultrasound