title: [Phosphoinositides: the lipids coordinating cell dynamics].
abstract: Within the glycerophospholipid family, phosphoinositides, which are minor components of eukaryotic cell membranes, play a critical role as spatiotemporal organizers of cell dynamics. By specifically interacting with proteins, they coordinate the formation and the organization of multiprotein complexes involved in cell signaling, intracellular trafficking and cytoskeleton rearrangement. The highly precise spatiotemporal dynamics of phosphoinositides-regulated mechanisms is ensured by kinases and phosphatases that specifically produce, hydrolyze and control the interconversion of these lipids. The direct implication of these enzymes in human pathologies such as genetic diseases, cancer or infectious pathologies, and the recent arrival of inhibitors targeting some phosphoinositide kinases in clinic, illustrate the mandatory functions of these fascinating lipids.
authors.affiliation: Inserm UMR 1048, institut des maladies métaboliques et cardiovasculaires (I2MC), université Toulouse III Paul-Sabatier, 1, avenue Jean Poulhès, BP 84225, 31432 Toulouse cedex 04, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Viaud
authors.affiliation: Inserm UMR 1048, institut des maladies métaboliques et cardiovasculaires (I2MC), université Toulouse III Paul-Sabatier, 1, avenue Jean Poulhès, BP 84225, 31432 Toulouse cedex 04, France - Centre hospitalier universitaire de Toulouse, laboratoire d'hématologie, 31059 Toulouse Cedex 03, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Payrastre
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000639:trends; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D010716:Phosphatidylinositols / Q000145:classification / Q000378:metabolism / Q000502:physiology*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D013927:Thrombosis / Q000235:genetics / Q000378:metabolism / Q000628:therapy
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D010716:Phosphatidylinositols; D000081082:Phosphoinositide-3 Kinase Inhibitors