title: Fever tree revisited: From malaria to autoinflammatory diseases.
abstract: Over the centuries the idea of recurrent fevers has mainly been associated with malaria, but many other fevers, such as typhoid and diphtheria were cause for concern. It is only in recent times, with the more severe forms of fever from infectious origin becoming less frequent or a cause for worry that we started noticing recurrent fevers without any clear infectious cause, being described as having a pathogenesis of autoinflammatory nature. The use of molecular examinations in many cases can allow a diagnosis where the cause is monogenic. In other cases, however the pathogenesis is likely to be multifactorial and the diagnostic-therapeutic approach is strictly clinical. The old fever tree paradigm developed to describe fevers caused by malaria has been revisited here to describe today's periodic fevers from the periodic fever adenitis pharyngitis aphthae syndrome to the more rare autoinflammatory diseases. This model may allow us to place cases that are yet to be identified which are likely to be of multifactorial origin.
authors.affiliation: Serena Pastore, Andrea Taddio, Alberto Tommasini, Department of Pediatrics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Pastore
authors.affiliation: Serena Pastore, Andrea Taddio, Alberto Tommasini, Department of Pediatrics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy.
authors.forename: Josef
authors.initials: J
authors.lastname: Vuch
authors.affiliation: Serena Pastore, Andrea Taddio, Alberto Tommasini, Department of Pediatrics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy.
authors.forename: Anna Monica
authors.initials: AM
authors.lastname: Bianco
authors.affiliation: Serena Pastore, Andrea Taddio, Alberto Tommasini, Department of Pediatrics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Taddio
authors.affiliation: Serena Pastore, Andrea Taddio, Alberto Tommasini, Department of Pediatrics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Tommasini
keywords: Autoinflammatory diseases; Genetics; History of medicine; Interleukin-1; Malaria; Periodic fever adenitis pharyngytis aphthe syndrome; Recurrent fevers; The fever tree