title: Plasma Adiponectin Concentrations and Adiponectin Gene Polymorphisms Are Associated with Bronchial Asthma in the Chinese Li Population.
abstract: The purpose of this study was to determine the clinical significance of changes in the plasma adiponectin concentration in patients with bronchial asthma and to test the association between the single nucleotide polymorphisms (SNPs) rs2241766 and rs1501299 in the ADIPOQ gene and bronchial asthma in the Chinese Li population. We selected 120 cases and 120 controls, and plasma adiponectin, interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-α) levels were measured by enzyme-linked immunosorbent assay (ELISA). In addition, we genotyped two tag single nucleotide polymorphisms (tSNPs) and evaluated their association with bronchial asthma using the χ2 test and genetic model analysis. Compared to controls, patients with acute exacerbation of bronchial asthma showed significantly lower adiponectin and significantly higher IL-6 and TNF-α levels (p<0.01). A positive association was found between the rs1501299 SNP and acute exacerbation (OR=1.62; 95% CI=1.08-2.43; p=0.019). The inverse correlation between the plasma adiponectin concentration and asthma exacerbation indicates that adiponectin may play a protective role in the pathogenesis of asthma. Meanwhile, our findings suggest that ADIPOQ polymorphisms influence the risk of developing bronchial asthma in Chinese Li population.
authors.affiliation: Emergency Department of Hainan Provincial People's Hospital , Haikou, 570102, China.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Ding
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: Respiratory Department of Hainan Nongken Jeneral Hospital, Haikou, 570311 China.
authors.forename: Haiwu
authors.initials: H
authors.lastname: He
authors.affiliation: Respiratory Department of Hainan Nongken Jeneral Hospital, Haikou, 570311 China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Shi
authors.affiliation: Emergency Department of Hainan Provincial People's Hospital , Haikou, 570102, China.
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.affiliation: Emergency Department of First People's Hospital of Xi'an, Xi'an, 710002, China.
authors.forename: Shouchun
authors.initials: S
authors.lastname: Yan
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China AND National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
keywords: Adiponectin; Asthma; Case-control studies