title: Amantadine-induced livedo reticularis--Case report.
abstract: Livedo reticularis is a spastic-anatomical condition of the small vessels which translates morphologically by a reticular pattern, interspersing cyanosis, pallor and erythema. The same can be congenital or acquired. Among the acquired, we highlight the physiological livedo reticularis and the idiopathic livedo by vasospasm; the latter configures the most common cause. The drug-induced type is less common. The drugs amantadine and norepinephrine are often implicated. Cyanosis is usually reversible if the causative factor is removed, however, with chronicity, the vessels may become permanently dilated and telangiectatic. We report a case of a patient diagnosed with Parkinson's disease with chronic livedo reticularis associated with the use of amantadine and improvement after discontinuation of the drug.
authors.affiliation: Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Maria Victória
authors.initials: MV
authors.lastname: Quaresma
authors.affiliation: Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Ana Carolina Dias
authors.initials: AC
authors.lastname: Gomes
authors.affiliation: Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Serruya
authors.affiliation: Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Dâmia Leal
authors.initials: DL
authors.lastname: Vendramini
authors.affiliation: Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Lara
authors.initials: L
authors.lastname: Braga
authors.affiliation: Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Alice Mota
authors.initials: AM
authors.lastname: Buçard
mesh_terms: D000368:Aged; D000547:Amantadine / Q000009:adverse effects*; D000978:Antiparkinson Agents / Q000009:adverse effects*; D006801:Humans; D054068:Livedo Reticularis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy; D012867:Skin / Q000098:blood supply / Q000473:pathology
chemical_list: D000978:Antiparkinson Agents; D000547:Amantadine