title: Uniformly Sclerotic Diffuse Large B-Cell Lymphoma of the Orbit.
abstract: Over a year, a 51-year-old man developed a mass in the anteromedial orbit in the region of the lacrimal sac that caused epiphora. Imaging studies disclosed no bone destruction. On biopsy, a sclerotic lesion was discovered populated by hyperchromatic cells that had been apparently distorted by crush artifact, indicative of fragile cells. The lesion simulated a sclerosing inflammatory process or a desmoplastic metastatic carcinoma. CD20 revealed that the background cells were large neoplastic B-lymphocytes. A systemic workup uncovered widespread skeletal disease. The patient is undergoing R-CHOP chemotherapy with a relatively favorable prognosis due to negative testing for MYC.
authors.affiliation: *David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts; †Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; and ‡Ophthalmic Plastic Surgery Service, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, U.S.A.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Jakobiec
authors.forename: Anna M
authors.initials: AM
authors.lastname: Stagner
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Lefebvre
mesh_terms: D001706:Biopsy; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000000981:diagnostic imaging*; D009918:Orbital Neoplasms / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed