title: Green tea beverages enriched with catechins with a galloyl moiety reduce body fat in moderately obese adults: a randomized double-blind placebo-controlled trial.
abstract: Objective To determine whether ingesting a green tea beverage enriched with catechins with a galloyl moiety during a meal reduces body fat in moderately obese adults. Design Randomized double-blind placebo-controlled study. Subjects A total of 126 obese subjects (25 ≤ body mass index < 30 kg m(-2)) were randomly assigned to a group receiving green tea beverages without catechins (placebo), or a group receiving green tea beverages with a low or high content of catechins with a galloyl moiety. Each subject ingested 500 mL bottled green tea beverages containing 25, 180, or 279.5 mg green tea catechins (0, 149.5, or 246.5 mg catechins with a galloyl moiety, respectively), at mealtimes for 12 weeks; the subjects were instructed to ingest the beverage during the meal that had the highest fat content on that day. Methods Anthropometric measurements and blood chemistry analysis were performed during the run-in period; at weeks 0, 4, 8, and 12 of the intake period; and at the end of the withdrawal period. Abdominal fat area was measured by computed tomography at weeks 0, 8, and 12 of the intake period and at the end of the withdrawal period. Results Both the low- and high-dose groups exhibited significant reductions in visceral and subcutaneous fat areas compared to the control group at 12 weeks post-intervention. Conclusion Ingestion of a green tea beverage enriched with catechins with a galloyl moiety during a high-fat meal reduces body fat in moderately obese adults.
authors.affiliation: Central Research Institute, ITO EN, Ltd, Shizuoka, 421-0516, Japan. m-kobayasi@itoen.co.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Central Research Institute, ITO EN, Ltd, Shizuoka, 421-0516, Japan. m-kobayasi@itoen.co.jp.
authors.forename: Takanori
authors.initials: T
authors.lastname: Kawano
authors.affiliation: Central Research Institute, ITO EN, Ltd, Shizuoka, 421-0516, Japan. m-kobayasi@itoen.co.jp.
authors.forename: Yuuichi
authors.initials: Y
authors.lastname: Ukawa
authors.affiliation: Central Research Institute, ITO EN, Ltd, Shizuoka, 421-0516, Japan. m-kobayasi@itoen.co.jp.
authors.forename: Yuko M
authors.initials: YM
authors.lastname: Sagesaka
authors.affiliation: Fukuhara Hospital, Hokkaido, 061-1351, Japan.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Fukuhara
mesh_terms: D000328:Adult; D001835:Body Weight / Q000187:drug effects; D002392:Catechin / Q000737:chemistry* / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D013662:Tea / Q000737:chemistry*
chemical_list: D013662:Tea; D002392:Catechin