title: A life-threatening presentation of eosinophilic granulomatosis with polyangiitis.
abstract: : Necrotizing eosinophilic myocarditis (NEM) is a life-threatening condition that needs rapid diagnosis by endomyocardial biopsy and hemodynamic support usually by mechanical circulatory systems. We present the case of a 25-year-old Caucasian man who developed a refractory cardiogenic shock due to a NEM that was supported with a peripheral veno-arterial extracorporeal membrane oxygenation associated with intravenous steroids and recovered after 2 weeks. Further instrumental investigations lead to the final diagnosis of NEM as first presentation of eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome), remarking the importance of identifying the systemic disorder that usually triggers the eosinophilic damage of the myocardium.
authors.affiliation: aDe Gasperis CardioCenter bUnit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Ammirati
authors.forename: Manlio
authors.initials: M
authors.lastname: Cipriani
authors.forename: Francesco
authors.initials: F
authors.lastname: Musca
authors.forename: Edgardo
authors.initials: E
authors.lastname: Bonacina
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pedrotti
authors.forename: Alberto
authors.initials: A
authors.lastname: Roghi
authors.forename: Arash
authors.initials: A
authors.lastname: Astaneh
authors.forename: Jan W
authors.initials: JW
authors.lastname: Schroeder
authors.forename: Sandra
authors.initials: S
authors.lastname: Nonini
authors.forename: Claudio F
authors.initials: CF
authors.lastname: Russo
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Oliva
authors.forename: Maria
authors.initials: M
authors.lastname: Frigerio
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D001706:Biopsy; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D015199:Extracorporeal Membrane Oxygenation; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008297:Male; D009205:Myocarditis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D012770:Shock, Cardiogenic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013256:Steroids / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids