title: Novel self-assembled mesalamine-sucralfate complexes: preparation, characterization, and formulation aspects.
abstract: Two well-known active agents, mesalamine (MES) and sucralfate (SUC), were investigated for possible utilization as fixed-dose combination product. The anti-inflammatory action of MES in association with bioadhesiveness and mucosal healing properties of SUC were considered promising for the development of a new compound containing both molecules, aimed as an improved treatment of ulcerative colitis. The present study investigates the capacity of the two active agents to interact and generate a new and stable entity via self-assembling. Spray-drying was used to co-process the two active principles from an aqueous mixture where the ratio MES:SUC was in the range 25:75, 50:50, and 75:25. The structural data (X-Ray, FTIR, SEM, DSC, and (1)H NMR) have shown that MES and SUC are interacting leading to complexes with properties differing from those of each separate active agent and from their physical blends. (1)H NMR results indicated that complexation occurred when the aqueous suspensions of drugs were mixed, prior to spray-drying. Drug-drug self-assembling was the driving mechanism in the formation of the new entity. Based on the structural data, a hypothetical structure of the complex was proposed. Co-processing of MES and SUC represents a simple and useful procedure to prepare new self-assembled compounds by valorizing the ionic interactions between the two entities. Preliminary studies with oral solid dosage forms based on MES-SUC complexes tested in vitro have shown a controlled MES release, opening the perspective of a new colon-targeted delivery system and a novel class of compounds with therapeutic application in inflammatory bowel diseases.
authors.affiliation: a Department of Chemistry and Center Pharmaqam , Université du Québec à Montréal , Montréal , Québec , Canada.
authors.forename: Pompilia
authors.initials: P
authors.lastname: Ispas-Szabo
authors.affiliation: a Department of Chemistry and Center Pharmaqam , Université du Québec à Montréal , Montréal , Québec , Canada.
authors.forename: Mihaela Maria
authors.initials: MM
authors.lastname: Friciu
authors.affiliation: a Department of Chemistry and Center Pharmaqam , Université du Québec à Montréal , Montréal , Québec , Canada.
authors.forename: Phuong
authors.initials: P
authors.lastname: Nguyen
authors.affiliation: a Department of Chemistry and Center Pharmaqam , Université du Québec à Montréal , Montréal , Québec , Canada.
authors.forename: Yves
authors.initials: Y
authors.lastname: Dumoulin
authors.affiliation: a Department of Chemistry and Center Pharmaqam , Université du Québec à Montréal , Montréal , Québec , Canada.
authors.forename: Mircea Alexandru
authors.initials: MA
authors.lastname: Mateescu
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods*; D065546:Drug Liberation; D009682:Magnetic Resonance Spectroscopy; D019804:Mesalamine / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013392:Sucralfate / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D013607:Tablets; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D004338:Drug Combinations; D013607:Tablets; D019804:Mesalamine; D013392:Sucralfate
keywords: Co-processing; drug complex; drug delivery; inflammatory bowel diseases (IBD); mesalamine; self-assembling; spray-drying; structural analysis; sucralfate