title: Nano-porous nitrocellulose liquid bandage modulates cell and cytokine response and accelerates cutaneous wound healing in a mouse model.
abstract: Nitrocellulose liquid bandage (L-Bandage) is extensively used in hard-to-cover cuts and wounds management, owing to its flexibility, softness, transparency, and conformability. However, evidence supporting their mechanisms of action as wound dressing is scanty. This study introduces a novel nano-porous L-Bandage, and provides results from a mouse full-thickness wound model investigating its mechanism of action on wound healing. Different characteristics, such as porosity, mechanical properties and water vapor transmission rate (WVTR) were determined. The L-Bandage formed film had a porous network structure with mean diameter of 18 nm that could effectively prevent the bacterial invasion, and favorable properties of tensile strength, elongation, and WVTR. The L-Bandage treated wound exhibited accelerated healing, with reduced inflammations, enhanced wound re-epithelialization, contraction, granulation tissue formation, and rapid angiogenesis. Our data suggested that L-Bandage could serve as a promising wound dressing, because of its desirable properties for wound healing.
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Fujian 362021, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Mu
authors.affiliation: Central Laboratory, Wannan Medical College, Anhui 241000, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Fujian 362021, China.
authors.forename: Caizhen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Fujian 362021, China.
authors.forename: Xiufang
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Fujian 362021, China.
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Fujian 362021, China.
authors.forename: Ruyu
authors.initials: R
authors.lastname: Bai
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Fujian 362021, China.
authors.forename: Xunxun
authors.initials: X
authors.lastname: Wu
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Fujian 362021, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Fujian Medical University, Fujian 362000, China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Wu
authors.affiliation: School of Biomedical Sciences, Huaqiao University, Fujian 362021, China. Electronic address: diaoyong@hqu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Diao
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D047070:Bandages, Hydrocolloid; D002175:Candida / Q000187:drug effects; D003101:Collodion / Q000737:chemistry* / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D058608:Nanopores; D013499:Surface Properties; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D016207:Cytokines; D003101:Collodion
keywords: Nano-porous; Nitrocellulose liquid bandage; Wound dressing; Wound healing