title: Recent advances in the biosynthesis of unusual polyketide synthase substrates.
abstract: This highlight provides an overview of recent advances in understanding the diversity of polyketide synthase (PKS) substrate building blocks. Substrates functioning as starter units and extender units contribute significantly to the chemical complexity and structural diversity exhibited by this class of natural products. This article complements and extends upon the current comprehensive reviews that have been published on these two topics (Moore and Hertweck, Nat. Prod. Rep., 2002, 19, 70; Chan et al., Nat. Prod. Rep., 2009, 1, 90; Wilson and Moore, Nat. Prod. Rep., 2012, 29, 72).
authors.affiliation: Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA. bsmoore@ucsd.edu.
authors.forename: Lauren
authors.initials: L
authors.lastname: Ray
authors.affiliation: Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA. bsmoore@ucsd.edu and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093-0204, USA.
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Moore
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D010453:Peptide Synthases / Q000145:classification / Q000378:metabolism*; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D001688:Biological Products; D061065:Polyketides; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase