title: Association of interleukin-1 receptor antagonist VNTR polymorphism and risk of pre-eclampsia in southeast Iranian population.
abstract: OBJECTIVE
  Pre-eclampsia (PE) is an obstetric disorder that may result in maternal and neonatal mortality and morbidity. Growing evidence indicates that cytokines, such as interleukins, are involved in the pathogenesis of this complication. Hence the current study aimed to assess the possible association between interleukin-1 receptor antagonist (IL-1Ra) VNTR polymorphism, and PE susceptibility in southeast Iranian women.
  
  
  METHODS
  The IL-Ra VNTR polymorphism was evaluated in 192 PE women and 186 age-matched normotensive pregnant women by the polymerase chain reaction method.
  
  
  RESULTS
  The frequency of the A2 allele and the A2A2 genotype of IL-Ra VNTR polymorphism was significantly lower in PE patients compared to controls: therefore, A2 allele may play a protective role in PE development (odds ratio = 0.13 95% CI, [0.04-0.03]; P < 0.0001). In addition, there was no relation between the IL-Ra VNTR polymorphism and severity of the disease.
  
  
  CONCLUSIONS
  The A2 allele of the IL-Ra VNTR polymorphism could be a protective factor for PE susceptibility.
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.|Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Salimi
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.|Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran.
authors.forename: Milad
authors.initials: M
authors.lastname: Mohammadoo-Khorasani
authors.affiliation: Department of Biology, Zabol University, Zabol, Iran.
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Mousavi
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshty University of Medical Sciences, Tehran, Iran.
authors.forename: Minoo
authors.initials: M
authors.lastname: Yaghmaei
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.|Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Mokhtari
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.|Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Farajian-Mashhadi
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007492:Iran; D018598:Minisatellite Repeats; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein
keywords: VNTR polymorphism; gene; interleukin-1 receptor antagonist; pre-eclampsia