title: Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue.
abstract: OBJECTIVE
  To evaluate the effects of nitrofurazone on the correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue in rats.
  
  
  METHODS
  A defect in the abdominal wall was created and corrected with polypropylene mesh in 20 rats. They were randomly distributed into four groups: control, fibrous mesh, nitrofurazone and nitrofurazone dip in the mesh. Euthanasia was performed in 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects.
  
  
  RESULTS
  All animals had adhesions. However, no statistically significant difference (p>0.05) when compared between groups. Similarly microscopic analysis, in which there was no statistical significance level for the evaluated parameters such as mono and polymorphonuclear lymphocytes, granuloma, fibrosis, necrosis and collagen proliferation.
  
  
  CONCLUSIONS
  There was no significant effect on the abdominal wall defect repair with polypropylene mesh surrounded by fibrous tissue when dipped in nitrofurazone 2%.
authors.affiliation: Department of General Surgery, Universidade Estadual do Pará, Belem, PA, Brazil.
authors.forename: Edson Yuzur
authors.initials: EY
authors.lastname: Yasojima
authors.affiliation: UEPA, Belem, PA, Brazil.
authors.forename: Rubens Fernando Gonçalves
authors.initials: RF
authors.lastname: Ribeiro Júnior
authors.affiliation: School of Medicine, Centro Universitário do Estado do Pará, Belem, PA, Brazil.
authors.forename: Thyago Cezar Prado
authors.initials: TC
authors.lastname: Pessôa
authors.affiliation: School of Medicine, Centro Universitário do Estado do Pará, Belem, PA, Brazil.
authors.forename: Lainy Carollyne da Costa
authors.initials: LC
authors.lastname: Cavalcante
authors.affiliation: School of Medicine, Centro Universitário do Estado do Pará, Belem, PA, Brazil.
authors.forename: Suzana Rodrigues
authors.initials: SR
authors.lastname: Ramos
authors.affiliation: School of Medicine, Centro Universitário do Estado do Pará, Belem, PA, Brazil.
authors.forename: Yuri Aarão Amaral
authors.initials: YA
authors.lastname: Serruya
authors.affiliation: School of Medicine, Centro Universitário do Estado do Pará, Belem, PA, Brazil.
authors.forename: Mateus Malta
authors.initials: MM
authors.lastname: de Moraes
mesh_terms: D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D006555:Hernia, Ventral / Q000601:surgery; D059685:Herniorrhaphy / Q000379:methods; D008422:Materials Testing; D009583:Nitrofurazone / Q000494:pharmacology*; D011126:Polypropylenes / Q000627:therapeutic use*; D011897:Random Allocation; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D011126:Polypropylenes; D009583:Nitrofurazone