title: Femtoliter-scale optical nanofiber sensors.
abstract: We report a robust and sensitive optical nanofiber sensor with a femtoliter-scale detection volume. The sensor is fabricated by embedding a 800-nm-diameter nanofiber into a microfluidic chip with probing light propagated perpendicular to a 5-μm-wide detection channel. To verify the effectiveness of the sensor, we present measurements of fluorescence intensity and refractive index (RI) with detection limits of 1 × 10(-7) M for fluorescein and 2.8 × 10(-4) RIU, respectively. The femtoliter-scale optical nanofiber sensor shown here may provide a compact and versatile sensing platform for sensitive and fast detection of ultra-low-volume samples, as well as studying the dynamics of single molecule.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Li
authors.forename: Jinxia
authors.initials: J
authors.lastname: Mu
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
authors.forename: Limin
authors.initials: L
authors.lastname: Tong