title: Ameliorating Effect of Akebia quinata Fruit Extracts on Skin Aging Induced by Advanced Glycation End Products.
abstract: The accumulation of free radicals and advanced glycation end products (AGEs) in the skin plays a very important role in skin aging. Both are known to interact with each other. Therefore, natural compounds or extracts that possess both antioxidant and antiglycation activities might have great antiageing potential. Akebia quinata fruit extract (AQFE) has been used to treat urinary tract inflammatory disease in traditional Korean and Chinese medicines. In the present study, AQFE was demonstrated to possess antioxidant and antiglycation activity. AQFE protects human dermal fibroblasts (HDFs) from oxidative stress and inhibits cellular senescence induced by oxidative stress. We also found that AQFE inhibits glycation reaction between BSA and glucose. The antiglycation activity of AQFE was dose-dependent. In addition, the antiglycation activity of AQFE was confirmed in a human skin explant model. AQFE reduced CML expression and stimulated fibrillin-1 expression in comparison to the methyglyoxal treatment. In addition, the possibility of the extract as an anti-skin aging agent has also been clinically validated. Our analysis of the crow's feet wrinkle showed that there was a decrease in the depth of deep furrows in RI treated with AQFE cream over an eight-week period. The overall results suggest that AQFE may work as an anti-skin aging agent by preventing oxidative stress and other complications associated with AGEs formation.
authors.affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. biost@biospectrum.com.
authors.forename: Seoungwoo
authors.initials: S
authors.lastname: Shin
authors.affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. biouk@biospectrum.com.
authors.forename: Dahee
authors.initials: D
authors.lastname: Son
authors.affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. biotq@biospectrum.com.
authors.forename: Minkyung
authors.initials: M
authors.lastname: Kim
authors.affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. biotf@biospectrum.com.
authors.forename: Seungjun
authors.initials: S
authors.lastname: Lee
authors.affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. biosh@biospectrum.com.
authors.forename: Kyung-Baeg
authors.initials: KB
authors.lastname: Roh
authors.affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. biosc@biospectrum.com.
authors.forename: Dehun
authors.initials: D
authors.lastname: Ryu
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University, 2066, Seobu-Ro, Jangan Gu, Suwon City, Gyunggi Do 164-19, Korea. bioneer@skku.edu.
authors.forename: Jongsung
authors.initials: J
authors.lastname: Lee
authors.affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. bioso@biospectrum.com.
authors.forename: Eunsun
authors.initials: E
authors.lastname: Jung
authors.affiliation: Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea. pdh@biospectrum.com.
authors.forename: Deokhoon
authors.initials: D
authors.lastname: Park
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000494:pharmacology; D002460:Cell Line; D005260:Female; D000071838:Fibrillin-1; D000071837:Fibrillins; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005638:Fruit / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism; D019684:Magnoliopsida / Q000737:chemistry*; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000187:drug effects; D015595:Skin Aging / Q000187:drug effects*; D054392:Adipokines
chemical_list: D000975:Antioxidants; D000071838:Fibrillin-1; D000071837:Fibrillins; D017127:Glycation End Products, Advanced; D008239:Lysine; D008840:Microfilament Proteins; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C000605722:FBN1 protein, human; D054392:Adipokines; C048496:N(6)-carboxymethyllysine
keywords: AGE; Akebia quinata fruit extract; fibrillin-1; glycation; human skin explants