title: Prevalence of pain-related single nucleotide polymorphisms in patients of African origin with sickle cell disease.
abstract: Prospective pain genetics research is hindered by a lack of data on the prevalence of polymorphisms in pain-relevant genes for patients with sickle cell disease (SCD). For African-Americans in general, limited information is available in public databases.
  
  
  
  We prioritized and examined the genotype and allele frequencies of 115 SNPs from 49 candidate pain genes in 199 adult African-Americans and pediatric patients of African origin with SCD. Analyses were performed and compared with available data from public databases.
  
  
  
  Genotype and allele frequencies of a number of SNPs were found to be different between our cohort and those from the databases and between adult and pediatric subjects.
  
  
  
  As pain therapy is inadequate in a significant percentage of patients with SCD, candidate pain genetic studies may aid in designing precision pain medicine. We provide prevalence data as a reference for prospective genetic studies in this population.
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.
authors.forename: Ellie H
authors.initials: EH
authors.lastname: Jhun
authors.affiliation: Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainsville, FL, USA.|Department of Biobehavioral Health Science, University of Illinois at Chicago College of Nursing, Chicago, IL, USA.
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Northwestern University-Feinberg School of Medicine, Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Children's Memorial Hospital, Chicago, IL, USA.
authors.forename: A Kyle
authors.initials: AK
authors.lastname: Mack
authors.affiliation: Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainsville, FL, USA.|Department of Biobehavioral Health Science, University of Illinois at Chicago College of Nursing, Chicago, IL, USA.
authors.forename: Diana J
authors.initials: DJ
authors.lastname: Wilkie
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Molokie
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.
authors.forename: Zaijie Jim
authors.initials: ZJ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D000755:Anemia, Sickle Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D002648:Child; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D055815:Young Adult
keywords: African–American; SNPs; genotype; pain; pharmacogenomics; polymorphisms; population; sickle cell disease