title: The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease.
abstract: Diabetes is a risk factor for Alzheimer disease (AD). Apolipoprotein E (ApoE) and several genes related to AD have recently been identified by genome-wide association studies (GWAS) as being closely linked to lipid metabolism. Lipid metabolism and glucose-energy metabolism are closely related. Here, we review the emerging evidence regarding the roles of lipid and glucose metabolism in the modulation of β-amyloid, tau, and neurodegeneration during the pathogenesis of AD. Disruption of homeostasis of lipid and glucose metabolism affects production and clearance of β-amyloid and tau phosphorylation, and induces neurodegeneration. A more integrated understanding of the interactions among lipid, glucose, and protein metabolism is required to elucidate the pathogenesis of AD and to develop next-generation therapeutic options.
authors.affiliation: Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University Suita, Japan ; Department of Geriatric Medicine, Graduate School of Medicine, Osaka University Suita, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Sato
authors.affiliation: Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University Suita, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Morishita
keywords: Aβ; cholesterol; diabetes; neurodegeneration; tau