title: Potential of electrospun core-shell structured gelatin-chitosan nanofibers for biomedical applications.
abstract: Coaxial electrospinning is an upcoming technology that has emerged from the conventional electrospinning process in order to realize the production of nanofibers of less spinnable materials with potential applications. The present work focuses on the production of chitosan nanofibers in a benign route, using natural polymer as core template, mild solvent system and naturally derived cross-linkers. Nanofibers with chitosan as shell are fabricated by coaxial electrospinning with highly spinnable gelatin as core using aqueous acetic acid as solvent. For maintaining the biocompatibility and structural integrity of the core-shell nanofibers, cross-linking is carried out using naturally derived cross-linking agents, dextran aldehyde and sucrose aldehyde. The biological evaluation of gelatin/chitosan mat is carried out using human osteoblast like cells. The results show that the cross-linked core-shell nanofibers are excellent matrices for cell adhesion and proliferation.
authors.affiliation: Department of Chemistry, Indian Institute of Space Science and Technology, Thiruvananthapuram 695 547, Kerala, India.
authors.forename: K
authors.initials: K
authors.lastname: Jalaja
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Kharagpur, 721302 West Bengal, India.
authors.forename: Deboki
authors.initials: D
authors.lastname: Naskar
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Kharagpur, 721302 West Bengal, India.
authors.forename: Subhas C
authors.initials: SC
authors.lastname: Kundu
authors.affiliation: Department of Chemistry, Indian Institute of Space Science and Technology, Thiruvananthapuram 695 547, Kerala, India. Electronic address: nirmala@iist.ac.in.
authors.forename: Nirmala R
authors.initials: NR
authors.lastname: James
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry; D004560:Electricity; D005780:Gelatin / Q000737:chemistry*; D005976:Glutaral / Q000737:chemistry; D006801:Humans; D055595:Mechanical Phenomena; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010084:Oxidation-Reduction; D012997:Solvents / Q000737:chemistry; D013395:Sucrose / Q000737:chemistry; D013696:Temperature; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; D012997:Solvents; D013395:Sucrose; D005780:Gelatin; D048271:Chitosan; D005976:Glutaral
keywords: Chitosan; Core–shell nanofibers; Cross-linking; Dextran aldehyde; Gelatin; Sucrose aldehyde