title: Multifunctional Mesoporous Silica Nanoparticles Based on Charge-Reversal Plug-Gate Nanovalves and Acid-Decomposable ZnO Quantum Dots for Intracellular Drug Delivery.
abstract: A novel type of pH-responsive multifunctional mesoporous silica nanoparticle (MSN) was developed for cancerous cells drug delivery and synergistic therapy of tumor. MSNs were covered with a kind of cell-penetrating peptide, deca-lysine sequence (K10), to enhance their escape from the endosomes. After K10's primary amines were reacted with citraconic anhydride to form acid-labile β-carboxylic amides, zinc oxide (ZnO) quantum dots (QDs) were introduced to cap MSNs via electrostatic interaction. The obtained ZnO@MSN drug-delivery system (DDS) achieves "zero-premature" drug release under a physiological environment. However, once the DDS is transferred to the cancerous cells' acidic endosome, ZnO QDs would rapidly dissolve and the acid-labile amides on the side chain of K10 would hydrolyze to regenerate primary amines, resulting in the uncapping of MSNs and exposure of the cell-penetrating peptide K10. The regenerated K10 could help the DDS escape from the endosome and efficiently release the loaded drugs inside the cells. At the meantime, because of the cytotoxicity of ZnO QDs at their destination, the ZnO@MSN DDS may achieve a synergistic antitumor effect to improve the therapeutic index.
authors.affiliation: College of Materials Science & Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Materials Science & Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.affiliation: College of Materials Science & Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Meng-Fei
authors.initials: MF
authors.lastname: Li
authors.affiliation: College of Materials Science & Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
mesh_terms: D000143:Acids / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems; D004560:Electricity; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D042541:Intracellular Space / Q000378:metabolism; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D016062:Porosity; D045663:Quantum Dots / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry*; D012996:Solutions; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000143:Acids; D012996:Solutions; D012822:Silicon Dioxide; D004317:Doxorubicin; D015034:Zinc Oxide
keywords: ZnO quantum dots; charge reversal; drug-delivery system; mesoporous silica nanoparticles; pH-responsive