title: Removal of polycyclic synthetic musks and antineoplastic drugs in ozonated wastewater: Quantitation based on the data of differential spectroscopy.
abstract: This study examined the degradation behavior of polycyclic musks (PMs) and antineoplastic drugs (ADs) and the absorbance spectra of effluent organic matter (EfOM) in municipal wastewater by ozone. Specific ozone doses used in the experiments ranged from 0 to 1mg O3/mg dissolved organic matter (DOC). The examined PMs included galaxolide, tonalide, celestolide, traseolide and phantolide. ADs included busulfan, chlorambucil, cyclophosphamide, dacarbazine, flutamide, ifosfamide, tamoxifen and methotrexate. Strong monotonic albeit nonlinear correlations were found to exist between relative changes of EfOM absorbance at 254 nm (i.e. ΔA254/A(0)254) and the degradation of the selected PMs and ADs. This result was interpreted based on the concept of the simultaneous oxidation of EfOM and, on the other hand, PMs and ADs. This interpretation showed that PMs were degraded primarily via OH radical attack, with tonalide and phantolide being less reactive compared with the other PMs. ADs such as cyclophosphamide, ifosfamide and busulfan were also determined to undergo oxidation by OH radicals. Comparison of the behavior of the radical probe para-chlorobenzoic acid and the examined ADs and PMs allowed evaluating corresponding reaction rate constants for reactions between these species and OH radicals.
authors.affiliation: Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Longpan Road 159, Nanjing 210037, China. Electronic address: uwliwei@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Sri Lakshmi Bhargavi Pharma Pvt. Ltd., 3GF & 3,4,5FF, SDF Block-2, EPIP, TSIIC, Pashmylaram, Patancheru Mandal, Medak District, Telangana 502305, India.
authors.forename: Venkateswarlu
authors.initials: V
authors.lastname: Nanaboina
authors.affiliation: School of Resources and Materials, Northeastern University at Qinhuangdao, 066004, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Civil and Environmental Engineering Box 352700 University of Washington, Seattle, WA 98195-2700, United States.
authors.forename: Gregory V
authors.initials: GV
authors.lastname: Korshin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry*; D007189:Indans / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D010126:Ozone / Q000737:chemistry*; D013764:Tetrahydronaphthalenes / Q000737:chemistry*; D014865:Waste Disposal, Fluid / Q000379:methods; D062065:Wastewater; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans; D007189:Indans; D016877:Oxidants; D010126:Ozone; D013764:Tetrahydronaphthalenes; D062065:Wastewater; D014874:Water Pollutants, Chemical; C033119:galaxolide
keywords: Absorbance spectra; Antineoplastic drugs; Effluent organic matter (EfOM); Ozonation; Polycyclic musk