title: The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E2 levels in patients with rheumatoid arthritis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effects of non-surgical periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinase-8 (MMP-8), interleukin-6 (IL-6) and prostaglandin E2 (PGE2 ) in patients with rheumatoid arthritis (RA) with periodontal disease.
  
  
  METHODS
  Twenty-seven patients with gingivitis and periodontitis with RA, 26 patients with gingivitis and periodontitis that were systemically healthy and 13 periodontally and systemically healthy volunteers (control group) were included in this study. RA activity was assessed by disease activity score test. The clinical periodontal parameters, fasting venous blood and gingival crevicular fluid samples were obtained and gingival crevicular fluid MMP-8, IL-6 and PGE2 levels were evaluated at baseline and at 3 mo follow-up after non-surgical periodontal treatment.
  
  
  RESULTS
  Gingival crevicular fluid MMP-8, PGE2 and IL-6 levels were higher in all groups than the control group. Following periodontal therapy, there were significant decreases in gingival crevicular fluid MMP-8, PGE2 and IL-6 levels from patients with RA with periodontitis (p < 0.05). Plaque index, gingival index and bleeding on probing were significantly correlated with IL-6 and PGE2 at baseline and at 3 mo follow-up after non-surgical periodontal treatment.
  
  
  CONCLUSIONS
  Non-surgical periodontal therapy of patients with RA with periodontitis may provide beneficial effects on local inflammatory control via decreases in gingival crevicular fluid MMP-8, PGE2 and IL-6 levels.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.
authors.forename: Ş
authors.initials: Ş
authors.lastname: Kurgan
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Ö
authors.initials: Ö
authors.lastname: Fentoğlu
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Önder
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Acıbadem University, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Serdar
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Eser
authors.affiliation: Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, OH, USA.
authors.forename: D N
authors.initials: DN
authors.lastname: Tatakis
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Günhan
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications*; D015415:Biomarkers / Q000032:analysis; D003774:Dental Plaque Index; D012534:Dental Scaling; D015232:Dinoprostone / Q000032:analysis*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005891:Gingivitis / Q000150:complications / Q000628:therapy; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis*; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000032:analysis*; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification / Q000150:complications / Q000628:therapy; D010510:Periodontal Diseases / Q000150:complications* / Q000628:therapy*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D010518:Periodontitis / Q000145:classification / Q000150:complications / Q000628:therapy; D016745:Root Planing; D014421:Turkey
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; C488762:MMP8 protein, human; D020784:Matrix Metalloproteinase 8; D015232:Dinoprostone
keywords: interleukin-6; matrix metalloproteinase-8; periodontal disease; prostaglandin E2; rheumatoid arthritis