title: CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?
abstract: The complex pathogenesis of psoriasis is still not fully understood. The study by Sun et al. (2015) suggests that CYR61 (now named CCN1), a secreted matricellular protein, has a role in the pathogenesis of psoriasis, and thus targeting CCN1 represents a potential therapeutic strategy in its treatment.
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Taihao
authors.initials: T
authors.lastname: Quan
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Johnston
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Johann E
authors.initials: JE
authors.lastname: Gudjonsson
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: gjfisher@med.umich.edu.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Fisher
mesh_terms: D000818:Animals; D055515:Cysteine-Rich Protein 61 / Q000378:metabolism*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology*
chemical_list: D055515:Cysteine-Rich Protein 61; D018836:Inflammation Mediators