title: Cataplexy with Normal Sleep Studies and Normal CSF Hypocretin: An Explanation?
abstract: Patients with narcolepsy usually develop excessive daytime sleepiness (EDS) before or coincide with the occurrence of cataplexy, with the latter most commonly associated with low cerebrospinal fluid (CSF) hypocretin-1 levels. Cataplexy preceding the development of other features of narcolepsy is a rare phenomenon. We describe a case of isolated cataplexy in the context of two non-diagnostic multiple sleep latency tests and normal CSF-hypocretin-1 levels (217 pg/mL) who gradually developed EDS and low CSF-hypocretin-1 (< 110 pg/mL).
authors.affiliation: Sleep Disorders Centre, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: Panagis
authors.initials: P
authors.lastname: Drakatos
authors.affiliation: Sleep Disorders Centre, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.|King's College London, UK.
authors.forename: Guy
authors.initials: G
authors.lastname: Leschziner
mesh_terms: D000328:Adult; D002385:Cataplexy / Q000134:cerebrospinal fluid / Q000150:complications*; D006970:Disorders of Excessive Somnolence / Q000134:cerebrospinal fluid / Q000150:complications*; D006801:Humans; D008297:Male; D009290:Narcolepsy / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis*; D000068797:Orexins / Q000134:cerebrospinal fluid*; D017286:Polysomnography / Q000706:statistics & numerical data
chemical_list: D000068797:Orexins
keywords: cataplexy; hypocretin; narcolepsy; orexin