title: Injectable agents affecting subcutaneous fats.
abstract: Mesotherapy is an intradermal or subcutaneous injection of therapeutic agents to induce local effects, and was pioneered in Europe during the 1950s. For the past 2 decades, there has been significant interest in the use of mesotherapy for minimally invasive local fat contouring. Based on the theorized lipolytic effects of the agent phosphatidylcholine, initial attempts involved its injection into subcutaneous tissue. With further studies, however, it became apparent that the activity attributed to phosphatidylcholine mesotherapy was due to the adipolytic effects of deoxycholate, a detergent used to solubilize phosphatidylcholine. Since then, clinical trials have surfaced that demonstrate the efficacy of a proprietary formulation of deoxycholate for local fat contouring. Current trials on mesotherapy with salmeterol, a b-adrenergic agonist and lipolysis stimulator, are underway-with promising preliminary results as well.
authors.affiliation: Department of Dermatology, University of Colorado, Aurora, USA.
authors.forename: David Lk
authors.initials: DL
authors.lastname: Chen
authors.affiliation: Department of Dermatology, University of Colorado, Aurora, USA. jcohenderm@yahoo.com.|AboutSkin Dermatology and DermSurgery, Englewood and Lone Tree, Colorado, USA.|Department of Dermatology, University of California at Irvine, USA.
authors.forename: Joel L
authors.initials: JL
authors.lastname: Cohen
authors.affiliation: Skin Associates of South Florida, Coral Gables, USA.|Department of Dermatology & Cutaneous Surgery, University of Miami, Florida, USA.
authors.forename: Jeremy B
authors.initials: JB
authors.lastname: Green
mesh_terms: D017667:Adipocytes / Q000187:drug effects; D003840:Deoxycholic Acid / Q000494:pharmacology*; D006801:Humans; D007279:Injections, Subcutaneous; D057748:Mesotherapy; D050151:Subcutaneous Fat / Q000187:drug effects*
chemical_list: D003840:Deoxycholic Acid
keywords: fat contouring; lipolysis; mesotherapy