title: Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss.
abstract: In this article, the mechanism of inheritance behind inherited hearing loss and genetic susceptibility in noise-induced hearing loss are reviewed. Conventional treatments for sensorineural hearing loss (SNHL), i.e. hearing aid and cochlear implant, are effective for some cases, but not without limitations. For example, they provide little benefit for patients of profound SNHL or neural hearing loss, especially when the hearing loss is in poor dynamic range and with low frequency resolution. We emphasize the most recent evidence-based treatment in this field, which includes gene therapy and allotransplantation of stem cells. Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss. Although some treatments are still at the experimental stage, it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application.
authors.forename: Yong-qiang
authors.initials: YQ
authors.lastname: Yu
authors.forename: Huai-an
authors.initials: HA
authors.lastname: Yang
authors.forename: Ming
authors.initials: M
authors.lastname: Xiao
authors.forename: Jing-wei
authors.initials: JW
authors.lastname: Wang
authors.forename: Dong-yan
authors.initials: DY
authors.lastname: Huang
authors.forename: Yagesh
authors.initials: Y
authors.lastname: Bhambhani
authors.forename: Lyn
authors.initials: L
authors.lastname: Sonnenberg
authors.forename: Brenda
authors.initials: B
authors.lastname: Clark
authors.forename: Yuan-zhe
authors.initials: YZ
authors.lastname: Jin
authors.forename: Wei-neng
authors.initials: WN
authors.lastname: Fu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Yu
authors.forename: Xue-ting
authors.initials: XT
authors.lastname: Liang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000818:Animals; D055317:Evidence-Based Practice; D005818:Genetic Engineering; D015316:Genetic Therapy; D006319:Hearing Loss, Sensorineural / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D033581:Stem Cell Transplantation