title: An Overview of Organ-Specific Autoimmune Diseases Including Immunotherapy.
abstract: A significant number of individuals are affected by autoimmune diseases, which are caused by aberrant recognition of self by the immune system. A wide variety of cells and organ systems are targets of pathologic activation of the immune mediators. Effective and safe therapies aimed at managing the chronic inflammatory aspect of many autoimmune diseases remain elusive. This review will focus on the available interventions and discuss the future of the field to prevent organ destruction by the autoimmune process.
authors.affiliation: a Division of Pediatric Endocrinology, Department of Pediatrics , School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, NY , USA.
authors.forename: Lucy D
authors.initials: LD
authors.lastname: Mastrandrea
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D015551:Autoimmunity / Q000187:drug effects; D001685:Biological Factors / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007109:Immunity / Q000187:drug effects; D009928:Organ Specificity; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D001685:Biological Factors; D016207:Cytokines
keywords: Autoimmunity; T-cell; biologics; cytokine; diabetes; immunity; treatment