title: Competing endogenous RNA networks and gastric cancer.
abstract: Recent studies have showed that RNAs regulate each other with microRNA (miRNA) response elements (MREs) and this mechanism is known as "competing endogenous RNA (ceRNA)" hypothesis. Long non-coding RNAs (lncRNAs) are supposed to play important roles in cancer. Compelling evidence suggests that lncRNAs can interact with miRNAs and regulate the expression of miRNAs as ceRNAs. Several lncRNAs such as H19, HOTAIR and MEG3 have been found to be associated with miRNAs in gastric cancer (GC), generating regulatory crosstalk across the transcriptome. These MRE sharing elements implicated in the ceRNA networks (ceRNETs) are able to regulate mRNA expression. The ceRNA regulatory networks including mRNAs, miRNAs, lncRNAs and circular RNAs may play critical roles in tumorigenesis, and the perturbations of ceRNETs may contribute to the pathogenesis of GC.
authors.affiliation: Lei-Lei Guo, Section of Infection Control of the Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, Henan Province, China.
authors.forename: Lei-Lei
authors.initials: LL
authors.lastname: Guo
authors.affiliation: Lei-Lei Guo, Section of Infection Control of the Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, Henan Province, China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Song
authors.affiliation: Lei-Lei Guo, Section of Infection Control of the Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, Henan Province, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Lei-Lei Guo, Section of Infection Control of the Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, Henan Province, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Dai
authors.affiliation: Lei-Lei Guo, Section of Infection Control of the Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, Henan Province, China.
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Lei-Lei Guo, Section of Infection Control of the Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, Henan Province, China.
authors.forename: Kai-Juan
authors.initials: KJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D012313:RNA / Q000235:genetics / Q000378:metabolism*; D000079962:RNA, Circular; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics* / Q000378:metabolism; D020218:Response Elements; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D035683:MicroRNAs; D000079962:RNA, Circular; D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm; D012313:RNA
keywords: Competing endogenous RNA; Competitive endogenous RNAs networks; Gastric cancer; MicroRNA response elements; Perturbation