title: The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution.
abstract: More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China, attributed to smoky coal combustion-generated PAH pollution. Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients. CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke. The key carcinogen benzo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer. Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13's critical role in PAH-induced lung carcinogenesis.
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Gui-Zhen
authors.initials: GZ
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China.
authors.forename: Zhe-Sheng
authors.initials: ZS
authors.lastname: Wen
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Yun-Chao
authors.initials: YC
authors.lastname: Huang
authors.affiliation: Department of Pathology, The First People's Hospital of Qu Jing City, Qu Jing, China.
authors.forename: Hao-Bin
authors.initials: HB
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Gao-Feng
authors.initials: GF
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China.
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Huang
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Zhou
authors.affiliation: Department of Pathology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Qu
authors.affiliation: Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
authors.affiliation: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Guang-Biao
authors.initials: GB
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002274:Carcinogens, Environmental / Q000633:toxicity*; D002289:Carcinoma, Non-Small-Cell Lung / Q000139:chemically induced* / Q000473:pathology*; D054382:Chemokine CXCL13 / Q000032:analysis*; D002681:China; D006801:Humans; D051379:Mice; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*
chemical_list: D002274:Carcinogens, Environmental; D054382:Chemokine CXCL13; D011084:Polycyclic Aromatic Hydrocarbons
keywords: CXCL13; environmental pollutant; human; human biology; lung cancer; medicine