title: Colorectal cancer: Metastases to a single organ.
abstract: Colorectal cancer (CRC) is a common malignancy worldwide. In CRC patients, metastases are the main cause of cancer-related mortality. In a group of metastatic CRC patients, the metastases are limited to a single site (solitary organ); the liver and lungs are the most commonly involved sites. When metastatic disease is limited to the liver and/or lungs, the resectability of the metastatic lesions will dictate the management approach and the outcome. Less commonly, the site of solitary organ CRC metastasis is the peritoneum. In these patients, cytoreduction followed by hyperthermic intraperitoneal chemotherapy may improve the outcome. Rarely, CRC involves other organs, such as the brain, bone, adrenals and spleen, as the only site of metastatic disease. There are limited data to guide clinical practice in these cases. Here, we have reviewed the disease characteristics, management approaches and prognosis based on the metastatic disease site in patients with CRC with metastases to a single organ.
authors.affiliation: Sina Vatandoust, Christos S Karapetis, Department of Medical Oncology, Flinders Medical Centre, Adelaide, SA 5042, Australia.
authors.forename: Sina
authors.initials: S
authors.lastname: Vatandoust
authors.affiliation: Sina Vatandoust, Christos S Karapetis, Department of Medical Oncology, Flinders Medical Centre, Adelaide, SA 5042, Australia.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Price
authors.affiliation: Sina Vatandoust, Christos S Karapetis, Department of Medical Oncology, Flinders Medical Centre, Adelaide, SA 5042, Australia.
authors.forename: Christos S
authors.initials: CS
authors.lastname: Karapetis
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy; D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy; D010534:Peritoneal Neoplasms / Q000556:secondary* / Q000628:therapy; D016896:Treatment Outcome
keywords: Bone metastasis; Brain metastasis; Colorectal cancer; Disease management; Liver metastasis; Lung metastasis; Metastasis; Peritoneal metastasis; Prognosis