title: Asymmetry in cross-hippocampal connectivity in unilateral mesial temporal lobe epilepsy.
abstract: Mesial temporal lobe epilepsy (mTLE) is mostly characterized by hippocampal sclerosis (HS) changes. Although considerable progress has been made in understanding the altered functional network of mTLE patients, whether one side of the abnormal hippocampal (HP) structure will affect the other healthy side of the hippocampal network is still unclear. Here, we used a seed-based method to explore the commonly alterative hippocampal network in mTLE patients by comparing the bilateral hippocampal network of unilateral mTLE patients with healthy control participants. We observed that both sides of the hippocampal network in unilateral mTLE patients were changed independent of the affected or "healthy" side, which may suggest a common plasticity network for both sides of hippocampal sclerosis mesial temporal lobe epilepsy patients. Furthermore, using the HP as the ROI, we found that the functional connectivity of the intra-HP in the left mTLE-HS group was moderately positively correlated with the duration of the disease, while a strong negative correlation between functional connectivity of the intra-HP and duration were detected in the right mTLE-HS group, which suggested that it was easier for the right HP than the left HP to communicate with the contralateral HP according to the progression of mTLE disease because the hippocampus plays different roles in the communication and compensatory mechanism associated with the contralateral side of the hemisphere. We hope that this potential relevance may help us to better characterize mTLE with hippocampal sclerosis and ultimately assist in providing a better diagnosis and more accurate invasive treatments of mTLE.
authors.affiliation: Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: 248026233@qq.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: fanwenliang168@163.com.
authors.forename: Wenliang
authors.initials: W
authors.lastname: Fan
authors.affiliation: Department of Communication Sciences and Disorders, Massachusetts General Hospital Institute of Health Professions, Boston, MA, USA. Electronic address: kingsleyang@gmail.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: School of Life Science and Technology, Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address: song_shuyan@163.com.
authors.forename: Shuyan
authors.initials: S
authors.lastname: Song
authors.affiliation: Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: 309105825@qq.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: leiping_rosemary@126.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Lei
authors.affiliation: Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: lochan.shrestha@yahoo.com.
authors.forename: Lochan
authors.initials: L
authors.lastname: Shrestha
authors.affiliation: Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: gracegloriam@gmail.com.
authors.forename: Grace
authors.initials: G
authors.lastname: Mella
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China; Radiology and Medical Imaging Center, The First People's Hospital of Yibin, Sichuan 644000, China. Electronic address: q1530831809@qq.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address: xuhaibo1120@hotmail.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D012189:Retrospective Studies; D013223:Statistics as Topic; D055815:Young Adult
keywords: Brain plasticity; Hippocampal network; Mesial temporal lobe epilepsy; Resting state functional connectivity