title: Prolonged use of fondaparinux for perioperative bridging: a case report of a patient with mechanical heart valve and heparin-induced thrombocytopenia.
abstract: OBJECTIVE
  Current guidelines provide no recommendations on perioperative bridging for patients after mechanical heart valve replacement (MHVR) who also have a history of heparin-induced thrombocytopenia (HIT). We present a successful case of prolonged bridging with fondaparinux in a 69-year-old Chinese woman.
  
  
  METHODS
  The patient presented to our department with the aim for radical resection of oesophageal cancer. Fondaparinux has been administered alone at 2·5 mg subcutaneously once daily for 24 days during the interruption of warfarin perioperatively. There were no signs or symptoms of thromboembolic or bleeding throughout and after her hospitalization.
  
  
  CONCLUSIONS
  Fondaparinux may offer an option for management of the patients with MHVR who cannot use heparin products, but further clinical investigations are warranted.
authors.affiliation: Department of Pharmacy, Jinling Hospital, Nanjing, Jiangsu, China.
authors.forename: M
authors.initials: M
authors.lastname: Wei
authors.affiliation: Department of Cardio-thoracic Surgery, Jinling Hospital, Nanjing, Jiangsu, China.
authors.forename: C T
authors.initials: CT
authors.lastname: Wang
authors.affiliation: Department of Cardio-thoracic Surgery, Jinling Hospital, Nanjing, Jiangsu, China.
authors.forename: D M
authors.initials: DM
authors.lastname: Li
authors.affiliation: Department of Pharmacy, Jinling Hospital, Nanjing, Jiangsu, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Song
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D000077425:Fondaparinux; D006351:Heart Valves / Q000601:surgery*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D019990:Perioperative Care / Q000379:methods; D011134:Polysaccharides / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D011134:Polysaccharides; D006493:Heparin; D000077425:Fondaparinux
keywords: fondaparinux; heparin-induced thrombocytopenia; mechanical valve replacement; perioperative bridging