title: Medical Gains of Chondroitin Sulfate Upon Fucosylation.
abstract: Chondroitin sulfate (CS) is a glycosaminoglycan (GAG) composed of alternating N-acetyl galactosamine and glucuronic acid units within disaccharide building blocks. CS is a key functional component in proteoglycans of cartilaginous tissues. Owing to its numerous biological roles, CS is widely explored in the pharmaceutical market as nutraceutical ingredient commonly utilized against arthritis, osteoarthrosis, and sometimes osteoporosis. Tissues like shark cartilage and bovine trachea are common sources of CS. Nonetheless, a new CS type has been introduced and investigated in the last few decades in what regards its medical potentials. It is named fucosylated chondroitin sulfate (FucCS). This less common CS type is isolated exclusively from the body wall of sea cucumbers. The presence of fucosyl branching units in the holothurian FucCS gives to this unique GAG, therapeutic properties in various pathophysiological systems which are inexistent in the common CS explored in the market. Examples of these systems are coagulation, thrombosis, hemodialysis, atherosclerosis, cellular growth, angiogenesis, fibrosis, tumor growth, inflammation, viral and protozoan infections, hyperglycemia, diabetes-related pathological events and tissue damage. This report aims at describing the medical benefits gained upon fucosylation of CS. Clinical prospects of these medical benefits are also discussed herein.
authors.affiliation: R. Prof. Rodolpho Paulo Rocco, 255, HUCFF-4A01, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil. pominvh@bioqmed.ufrj.br.
authors.forename: Vitor H
authors.initials: VH
authors.lastname: Pomin
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D050197:Atherosclerosis / Q000188:drug therapy; D001777:Blood Coagulation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002809:Chondroitin Sulfates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D006031:Glycosylation; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011528:Protozoan Infections / Q000188:drug therapy; D012616:Sea Cucumbers / Q000378:metabolism; D013927:Thrombosis / Q000188:drug therapy; D014777:Virus Diseases / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; C517150:fucosylated chondroitin sulfate; D002809:Chondroitin Sulfates