title: Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.
abstract: The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting. Given these functions, the endocrine FGFs have therapeutic potential in a wide array of chronic human diseases, including obesity, type 2 diabetes, cancer, and kidney and cardiovascular disease. However, the safety and feasibility of chronic endocrine FGF administration has been challenged, and FGF analogues and mimetics are now being investigated. Here, we discuss current knowledge of the complex biology of the endocrine FGFs and assess how this may be harnessed therapeutically.
authors.affiliation: Clinica Medica "Cesare Frugoni", Dipartimento Interdisciplinare di Medicina, Università degli studi di Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy.|Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori "Giovanni Paolo II", Viale O. Flacco 65, 70124 Bari, Italy.|Letscom srl, via T. Bell 5, 00015 Monterotondo (RM), Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Degirolamo
authors.affiliation: Clinica Medica "Cesare Frugoni", Dipartimento Interdisciplinare di Medicina, Università degli studi di Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Sabbà
authors.affiliation: Clinica Medica "Cesare Frugoni", Dipartimento Interdisciplinare di Medicina, Università degli studi di Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy.|Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori "Giovanni Paolo II", Viale O. Flacco 65, 70124 Bari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Moschetta
mesh_terms: D000818:Animals; D002908:Chronic Disease / Q000188:drug therapy*; D015507:Drugs, Investigational / Q000494:pharmacology / Q000627:therapeutic use; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000819:agonists / Q000502:physiology* / Q000627:therapeutic use*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008954:Models, Biological
chemical_list: D015507:Drugs, Investigational; C117476:FGF19 protein, human; C000717427:FGF23 protein, human; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23