title: Cardiac ion channels.
abstract: Ion channels are critical for all aspects of cardiac function, including rhythmicity and contractility. Consequently, ion channels are key targets for therapeutics aimed at cardiac pathophysiologies such as atrial fibrillation or angina. At the same time, off-target interactions of drugs with cardiac ion channels can be the cause of unwanted side effects. This manuscript aims to review the physiology and pharmacology of key cardiac ion channels. The intent is to highlight recent developments for therapeutic development, as well as elucidate potential mechanisms for drug-induced cardiac side effects, rather than present an in-depth review of each channel subtype.
authors.affiliation: a Lilly Research Laboratories ; Indianapolis , IN USA.
authors.forename: Birgit T
authors.initials: BT
authors.lastname: Priest
authors.affiliation: a Lilly Research Laboratories ; Indianapolis , IN USA.
authors.forename: Jeff S
authors.initials: JS
authors.lastname: McDermott
mesh_terms: D000200:Action Potentials; D000818:Animals; D016275:Atrial Function; D015220:Calcium Channels / Q000378:metabolism*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism*; D016276:Ventricular Function; D061566:Voltage-Gated Sodium Channels / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D015221:Potassium Channels; D061566:Voltage-Gated Sodium Channels
keywords: arrhythmia; cardiac function; cardiomyocyte; electrocardiogram; ion channel; pharmacology; vascular tone