title: Host-Guest Strategy to Reversibly Control a Chloride Carrier Process with Cyclodextrins.
abstract: Herein, we report a reversible modular chloride transport process based on host-guest competitive interactions between an imidazolium-based chloride carrier and beta-cyclodextrin. We report evidence for the formation of the supramolecular complex between 1,3-bis(2-(adamantan-1-yl)ethyl)imidazolium bis(trifluorometyl-sulfonyl)imide with two β-cyclodextrins. Through fluorescence assays in liposomes and black lipid membrane experiments, we demonstrate that the formation of the supramolecular complex results in the inhibition of the chloride transport. We show that the chloride transport process can be entirely restored in the presence of competitive adamantyl-functionalized guests. This is the first example of an entirely reversible modular chloride transport process in phospholipid bilayers involving a mobile carrier transporter and cyclodextrin supramolecular complex.
authors.affiliation: Département de Chimie, Université de Montréal, C. P. 6128 Succursale Centre-Ville, Montréal, Québec, H3C 3J7 (Canada), Fax: (+1) 514-343-7586.
authors.forename: Julien
authors.initials: J
authors.lastname: Gravel
authors.affiliation: Département de Chimie, Université de Montréal, C. P. 6128 Succursale Centre-Ville, Montréal, Québec, H3C 3J7 (Canada), Fax: (+1) 514-343-7586.
authors.forename: Julie
authors.initials: J
authors.lastname: Kempf
authors.affiliation: Département de Chimie, Université de Montréal, C. P. 6128 Succursale Centre-Ville, Montréal, Québec, H3C 3J7 (Canada), Fax: (+1) 514-343-7586. ar.schmitzer@umontreal.ca.
authors.forename: Andreea
authors.initials: A
authors.lastname: Schmitzer
keywords: anion transport; cyclodextrins; host-guest systems; mobile carrier; reversible process