title: Protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside, isolated from Annona squamosa leaves in thyrotoxicosis and in hepatic lipid peroxidation in rats.
abstract: Hitherto unknown protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside (THDMF-Rha); isolated from Annona squamosa leaves were evaluated in l-thyroxine (l-T4)-induced thyrotoxicosis in rats. Administration of l-T4 at 500μg/kg body weight for 12days increased the levels of serum thyroid hormones, the activity of 5'-monodeiodinase-I (5'DI) and hepatic glucose-6-phosphatase (G-6Pase) as well as lipid peroxidation (LPO); with a parallel decrease in the levels of cellular antioxidants and serum lipids. However, administration of the isolated THDMF-Rha at a pre-standardized dose for 15days ameliorated the l-T4-induced alterations in the levels of thyroid hormones, hepatic LPO, G-6-Pase, 5'DI activity, and cellular levels of antioxidants and improved the status of different serum lipids, suggesting its antithyroidal and antioxidative potential. As compared to standard antithyroid drug, propylthiouracil, THDMF-Rha appeared to be more promising.
authors.affiliation: School of Life Sciences, Devi Ahilya University, Indore 452017, India.
authors.forename: Sunanda
authors.initials: S
authors.lastname: Panda
authors.affiliation: School of Life Sciences, Devi Ahilya University, Indore 452017, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Kar
mesh_terms: D000818:Animals; D031041:Annona / Q000737:chemistry* / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D009005:Monosaccharides; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012210:Rhamnose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013963:Thyroid Hormones / Q000097:blood; D013971:Thyrotoxicosis / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D014280:Triglycerides / Q000097:blood
chemical_list: C423967:5,7,4'-trihydroxy-6,3'-dimethoxy-flavone-5-O-rhamnopyranoside; D000975:Antioxidants; D047309:Flavones; D005419:Flavonoids; D009005:Monosaccharides; D020011:Protective Agents; D013963:Thyroid Hormones; D014280:Triglycerides; D002784:Cholesterol; D005952:Glucose-6-Phosphatase; D012210:Rhamnose
keywords: Annona squamosa; Lipid peroxidation; Methoxy flavone; Protective effects; Thyrotoxicosis