title: Drugs related to the etiology of molar incisor hypomineralization: A systematic review.
abstract: BACKGROUND
  Molar incisor hypomineralization (MIH) is an idiopathic syndrome that has been associated with several etiologic factors. The authors' objective was to systematically review studies in which the investigators had studied how the etiology of MIH was related to medication intake.
  
  
  METHODS
  The search covered a period from January 1, 1965, to September 29, 2014. The search revealed 1,042 articles, to which the authors applied eligibility criteria and selected 20 studies for review. The authors considered 9 of the 20 studies to be high quality. The drugs used in these studies were chemotherapeutic drugs, antibiotics, asthma drugs, antiepileptic drugs, antiviral drugs, antifungal drugs, and antiparasitic drugs.
  
  
  RESULTS
  Two reviewers independently performed risk-of-bias assessment and data extraction. The investigators of all of the studies had reported enamel defects, but only 2 sets of investigators had used the term "molar incisor hypomineralization." Owing to the different methodologies used by the investigators of the selected studies, the authors could not perform a meta-analysis of the study results.
  
  
  CONCLUSIONS
  More well-designed prospective studies are needed to clarify the relationship between MIH and medication.
  
  
  CONCLUSIONS
  It would be convenient to establish a preventive protocol in patients with a potential risk of developing MIH to avoid the complications that are characteristic of this disease.
authors.forename: Clara
authors.initials: C
authors.lastname: Serna
authors.forename: Ascensión
authors.initials: A
authors.lastname: Vicente
authors.forename: Christian
authors.initials: C
authors.lastname: Finke
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Ortiz
mesh_terms: D003744:Dental Enamel Hypoplasia / Q000139:chemically induced*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology*; D006801:Humans; D004364:Pharmaceutical Preparations
chemical_list: D004364:Pharmaceutical Preparations
keywords: Enamel hypoplasia; drugs; enamel defects; enamel hypomineralization; enamel opacities; molar incisor hypomineralization