title: Bile acid elevation after Roux-en-Y gastric bypass is associated with cardio-protective effect in Zucker Diabetic Fatty rats.
abstract: BACKGROUND
  Roux-en-Y gastric bypass (RYGB) may improve cardiometabolic risk through alteration of bile acids and L-PGDS levels.
  
  
  OBJECTIVE
  The objective of this study was to investigate the effect of RYGB on aortic wall thickness, in relation to bile acid and L-PGDS metabolism.
  
  
  METHODS
  Zucker diabetic fatty (ZDF) rats were divided into two groups, ad lib (n = 4), and RYGB (n = 6). Bile acid and L-PGDS were measured presurgery and fourteen weeks post-surgery.
  
  
  RESULTS
  Elevation of bile acid levels following RYGB in Zucker Diabetic Fatty (ZDF) rodents was observed, as compared to ad lib. RYGB in ZDF rodents led to a significantly decreased aortic wall thickness (25%) as compared to ad lib control. Although bile acid metabolism is implicated in these alterations, other mediators are likely involved. Our laboratory has demonstrated lipocalin prostaglandin D2 synthase (L-PGDS) is a kno n cardiometabolic modulator that also functions as a bile acid binding protein. Therefore, L-PGDS levels were measured and a significant elevation was observed with RYGB compared to ad lib control.
  
  
  CONCLUSIONS
  Based on these findings, RYGB showed beneficial effect on aortic wall thickness, possibly through bile acids and L-PGDS elevation in a severely obese and diabetic rodent model.
authors.affiliation: Department of Biomedical Research, Winthrop University Hospital, Mineola, NY 11501, USA.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Surgery, Winthrop University Hospital, Mineola, NY 11501, USA; Department of Endocrinology, Winthrop University Hospital, Mineola, NY 11501, USA.
authors.forename: Raymond
authors.initials: R
authors.lastname: Lau
authors.affiliation: Department of Biomedical Research, Winthrop University Hospital, Mineola, NY 11501, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hall
authors.affiliation: Department of Biomedical Research, Winthrop University Hospital, Mineola, NY 11501, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Palaia
authors.affiliation: Department of Surgery, Winthrop University Hospital, Mineola, NY 11501, USA; Department of Medicine, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA.
authors.forename: Collin E
authors.initials: CE
authors.lastname: Brathwaite
authors.affiliation: Department of Biomedical Research, Winthrop University Hospital, Mineola, NY 11501, USA; Department of Medicine, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA. Electronic address: LRagolia@Winthrop.org.
authors.forename: Louis
authors.initials: L
authors.lastname: Ragolia
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental; D015390:Gastric Bypass / Q000009:adverse effects*; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications / Q000601:surgery*; D051381:Rats; D011924:Rats, Zucker
chemical_list: D001647:Bile Acids and Salts
keywords: Aortic wall thickness; Bile acid; Cardiovascular; L-PGDS; RYGB; ZDF rats