title: Four key questions surrounding thrombolytic therapy for submassive pulmonary embolism.
abstract: Submassive pulmonary embolism (PE) remains a vexing entity, and the appropriate use of thrombolytic therapy for this subgroup continues to be actively debated. Catheter-directed thrombolysis has shown efficacy for submassive PE and is gaining momentum because of theoretically improved safety. This review poses and responds to four questions that explore the complex issues surrounding optimal therapy of submassive PE.
authors.affiliation: Weill Cornell Medical College, New York, NY, USA aks9010@med.cornell.edu.
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Sista
authors.affiliation: Weill Cornell Medical College, New York, NY, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Horowitz
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Samuel Z
authors.initials: SZ
authors.lastname: Goldhaber
mesh_terms: D002407:Catheterization, Swan-Ganz; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D017410:Practice Guidelines as Topic; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D011859:Radiography; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents
keywords: catheter-directed therapy; pulmonary embolism; submassive PE; thrombolysis