title: Circulating Progenitor Cells and Childhood Cardiovascular Disease.
abstract: Circulating progenitor cells have been extensively studied in the context of heart disease in adults. In these patients, they have been demonstrated to be markers of myocardial injury and recovery as well as potential therapeutic agents. However, studies in children are much more limited. Here we review current knowledge pertaining to circulating progenitor cells in the context of childhood cardiovascular disease. Priorities for further research are also highlighted.
authors.affiliation: DeVos Cardiovascular Research Program of Spectrum Health and Van Andel Research Institute, 100 Michigan Street NE, Grand Rapids, MI, 49503, USA. eric.kort@vai.org.|Michigan State University, College of Human Medicine, 15 Michigan Street NE, Grand Rapids, MI, USA. eric.kort@vai.org.|Helen DeVos Children's Hospital, 100 Michigan Street NE, Grand Rapids, MI, USA. eric.kort@vai.org.
authors.forename: Eric J
authors.identifier: http://orcid.org/0000-0002-9966-7483
authors.initials: EJ
authors.lastname: Kort
authors.affiliation: Michigan State University, College of Human Medicine, 15 Michigan Street NE, Grand Rapids, MI, USA.
authors.forename: Lacey
authors.initials: L
authors.lastname: Croskey
authors.affiliation: Michigan State University, College of Human Medicine, 15 Michigan Street NE, Grand Rapids, MI, USA.
authors.forename: Taryn
authors.initials: T
authors.lastname: Scibienski
authors.affiliation: Michigan State University, College of Human Medicine, 15 Michigan Street NE, Grand Rapids, MI, USA.|Helen DeVos Children's Hospital, 100 Michigan Street NE, Grand Rapids, MI, USA.
authors.forename: Surender
authors.initials: S
authors.lastname: Rajasekaran
authors.affiliation: DeVos Cardiovascular Research Program of Spectrum Health and Van Andel Research Institute, 100 Michigan Street NE, Grand Rapids, MI, 49503, USA.|Michigan State University, College of Human Medicine, 15 Michigan Street NE, Grand Rapids, MI, USA.|Cardiovascular Institute, Stanford University, Palo Alto, CA, USA.
authors.forename: Stefan
authors.initials: S
authors.lastname: Jovinge
mesh_terms: D002315:Cardiopulmonary Bypass; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002648:Child; D006330:Heart Defects, Congenital / Q000503:physiopathology; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis; D013234:Stem Cells / Q000166:cytology*
chemical_list: D008565:Membrane Proteins
keywords: Cardiopulmonary bypass; Congenital heart disease; Progenitor cells; Stem cells