title: [Treatment of Adult Schizophrenic Patients With Depot Antipsychotics].
abstract: OBJECTIVE
  To determine the indications of long-acting antipsychotic injection and what its effectiveness and safety in adult patients with schizophrenia during the treatment maintenance phase.
  
  
  METHODS
  A clinical practice guideline was elaborated under the parameters of the Methodological Guide of the Ministerio de Salud y Protección Social to identify, synthesize and evaluate the evidence and make recommendations about the treatment and follow-up of adult patients with schizophrenia. The evidence of NICE guide 82 was adopted and updated. The evidence was presented to the Guideline Developing Group and recommendations, employing the GRADE system, were produced.
  
  
  RESULTS
  The literature review shows that the evidence has moderate to low quality. 8 articles were used. The risk of relapse was lower with depot risperidone and paliperidone palmitate when compared with placebo. For the risk of hospitalizations comparing depot antipsychotics (APD) versus oral AP, the result is inconclusive. Globally the second-generation APD had a lower risk of discontinuation when compared with placebo. The second generation AP had higher risk of extrapyramidal syndromes than placebo, as in the use of antiparkinsonian. The comparison of second-generation AP injections versus placebo showed an increased risk of early weight gain.
  
  
  CONCLUSIONS
  The use of depot antipsychotics in the maintenance phase of adult patients diagnosed with schizophrenia is recommended if there is no adherence to oral antipsychotics as the patient's preference. It is not recommended depot antipsychotics in the acute phase of schizophrenia in adults.
authors.affiliation: Médico psiquiatra, Master en Farmacología. Profesor Titular y Director Depto. de Psiquiatría, Universidad Nacional de Colombia, Bogotá, Colombia. Electronic address: lejaramillog@unal.edu.co.
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: Jaramillo González
authors.affiliation: Médico psiquiatra, psicoanalista, psiquiatra de enlace, magíster en Epidemiología Clínica. Profesor titular y Director del Departamento de Epidemiología Clínica y Bioestadística. Pontificia Universidad Javeriana. Hospital Universitario San Ignacio., Bogotá, Colombia.
authors.forename: Carlos
authors.initials: C
authors.lastname: Gómez Restrepo
authors.affiliation: Médica psiquiatra, Doctora en Epidemiología Clínica. Profesora asociada del Departamento de Psiquiatría, Facultad de Medicina. Universidad de Antioquia., Medellín, Antioquia, Colombia.
authors.forename: Jenny
authors.initials: J
authors.lastname: García Valencia
authors.affiliation: Médica, magístra en Epidemiología Clínica. Profesora instructora del Departamento de Epidemiología Clínica y Bioestadística. Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Ana María
authors.initials: AM
authors.lastname: de la Hoz Bradford
authors.affiliation: Médico Servicio Social Obligatorio. Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Ávila-Guerra
authors.affiliation: Médica psiquiatra, magístra en Epidemiología Clínica. Profesora asistente del departamento de Psiquiatría y Salud Mental. Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Adriana
authors.initials: A
authors.lastname: Bohórquez Peñaranda
keywords: Clinical Practice Guidelines; Esquizofrenia; Guía de práctica clínica; Schizophrenia