title: Elimination and elemental diet therapy in eosinophilic oesophagitis.
abstract: Eosinophilic oesophagitis (EoE) is a chronic immune-mediated disorder of the oesophagus. The incidence of EoE has been raised substantially and EoE has recently become the most prevalent cause of dysphagia among the adolescents. Food and aeroallergens are believed to play a major role in the pathogenesis. Current treatment includes topical steroids and dietary therapy. Dietary therapy with elimination of causative allergens could provide a durable long-term solution. Dietary therapy in EoE consists of in elemental and empiric elimination diets. Elemental diet with amino acid-based formula is most effective in achieving disease remission but poor taste makes adherence challenging. Empiric elimination diet based on avoidance of most common food allergens offers moderate response rates, the usefulness of allergy test-directed elimination diets is questioned by low response rates. In conclusion, dietary treatments for EoE seem promising, but further refinement is required before it can become standard care.
authors.affiliation: Department of Gastroenterology & Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Warners
authors.affiliation: Department of Respiratory Medicine and Allergy, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: B J
authors.initials: BJ
authors.lastname: Vlieg-Boerstra
authors.affiliation: Department of Gastroenterology & Hepatology, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address: a.j.bredenoord@amc.uva.nl.
authors.forename: A J
authors.initials: AJ
authors.lastname: Bredenoord
mesh_terms: D003680:Deglutition Disorders / Q000209:etiology; D057765:Eosinophilic Esophagitis / Q000178:diet therapy* / Q000209:etiology; D005512:Food Hypersensitivity / Q000150:complications / Q000178:diet therapy; D005526:Food, Formulated; D006801:Humans
keywords: Dietary treatment; Dysphagia; Eosinophilic oesophagitis; Food allergy