title: APOBEC3 Proteins in Viral Immunity.
abstract: Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons. Although their direct effect on modification of viral DNA has been clearly demonstrated, whether they play additional roles in innate and adaptive immunity to viruses is less clear. We review the data regarding the various steps in the innate and adaptive immune response to virus infection in which apolipoprotein B editing complex 3 proteins have been implicated.
authors.affiliation: Department of Microbiology, Abramson Cancer Center, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6142.
authors.forename: Spyridon
authors.initials: S
authors.lastname: Stavrou
authors.affiliation: Department of Microbiology, Abramson Cancer Center, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6142 rosss@mail.med.upenn.edu.
authors.forename: Susan R
authors.identifier: http://orcid.org/0000-0002-3094-3769
authors.initials: SR
authors.lastname: Ross
mesh_terms: D000071478:APOBEC Deaminases; D056704:Adaptive Immunity / Q000276:immunology; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003564:Cytidine Deaminase; D043525:Cytosine Deaminase / Q000235:genetics / Q000276:immunology*; D004279:DNA, Viral / Q000235:genetics / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology / Q000821:virology; D006801:Humans; D030361:Papillomavirus Infections / Q000276:immunology; D010322:Parvoviridae Infections / Q000276:immunology / Q000821:virology; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D004279:DNA, Viral; D043525:Cytosine Deaminase; D000071478:APOBEC Deaminases; C502889:APOBEC3 proteins, human; D003564:Cytidine Deaminase