title: Study of clinical spectrum and risk factors of neonatal candidemia.
abstract: BACKGROUND
  Candida colonization in neonates results in significant morbidity and mortality. The prevalence and clinical significance of neonatal candidemia are poorly understood.
  
  
  OBJECTIVE
  This study aimed to study clinical spectrum and risk factors of neonatal candidemia.
  
  
  METHODS
  108 cases of septicemia were studied. Blood samples were collected into Glucose broth and Bile broth, which are inoculated on Blood agar and MacConkey's agar and incubated at 37° C for 7 days. Candida species were isolated were confirmed by standard techniques.
  
  
  METHODS
  The data was collected and analyzed using by using SPSS IBM Company, Chicago, Version 16.0.
  
  
  RESULTS
  62 newborn patients who had a positive Candida blood culture. 47 (79.03%) were low birth weight and 37 (59.67%) were male. 19 (30.65%) were died. Candida species was a contributory factor to mortality in 14 (73.68%) patients. Among Candida isolates, Candida albicans was the commonest (65%) followed by Candida parapsilosis (15%) and Candida glabrata (10%). The risk factors like intrapartum use of antibiotics, vaginal delivery, low birth weight are identified in culture positive neonates.
  
  
  CONCLUSIONS
  Candida species are assuming an increasing role in nosocomial infections in neonates and is associated with an increased risk of mortality.
authors.affiliation: Department of Microbiology, JMF'S ACPM Medical College, Dhule, Maharashtra, India.
authors.forename: Rahul Gopichand
authors.initials: RG
authors.lastname: Wadile
authors.forename: Viraj Madhusudan
authors.initials: VM
authors.lastname: Bhate
mesh_terms: D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D058387:Candidemia / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D008297:Male; D008828:Microbiological Techniques; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis