title: Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life.
abstract: BACKGROUND
  After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD).
  
  
  OBJECTIVE
  To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD.
  
  
  METHODS
  A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed.
  
  
  RESULTS
  The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD.
  
  
  CONCLUSIONS
  A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.
authors.affiliation: Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Carolien N H
authors.initials: CN
authors.lastname: Abheiden
authors.affiliation: Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Rebecca
authors.initials: R
authors.lastname: van Doornik
authors.affiliation: Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Annet M
authors.initials: AM
authors.lastname: Aukes
authors.affiliation: Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands ; Department of Epidemiology and Biostatistics, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
authors.affiliation: Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.affiliation: Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Christianne J M
authors.initials: CJ
authors.lastname: de Groot
keywords: Alzheimer's disease; Early-onset dementia; Magnetic resonance imaging; Preeclampsia; Pregnancy-induced hypertension