title: MicroRNAs, TGF-β signaling, and the inflammatory microenvironment in cancer.
abstract: Inflammatory cells and mediators form a major part of the tumor microenvironment and play important roles in the regulation of cancer initiation, tumor cell proliferation, and metastasis. MicroRNAs (miRNAs) play important roles in several physiological and pathological processes, including the regulation of the inflammatory microenvironment in cancer. Transforming growth factor-β (TGF-β) is an inflammation-related cytokine that functions in both tumor suppression and promotion; however, its underlying molecular mechanisms remain unclear. Recent evidence indicates an association between miRNAs and TGF-β signaling, providing new insight into the nature of the inflammatory microenvironment in cancer. The present review is an overview of the interaction between miRNAs and inflammatory cytokines, with emphasis on the cross talk between TGF-β signaling and miRNAs and their influence on cancer cell behavior. The emerging roles of miRNAs in cancer-related inflammation and the potential to target miRNA signaling pathways for cancer therapy are also discussed.
authors.affiliation: Department of Pathology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, 215123, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, 310009, China.
authors.forename: Fengbo
authors.initials: F
authors.lastname: Huang
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, 310009, China.
authors.forename: Jinfan
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, 215123, China. wangsoly112@hotmail.com.|Institute of Radiology and Oncology, Soochow University, Suzhou, 215006, China. wangsoly112@hotmail.com.
authors.forename: Shouli
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D059016:Tumor Microenvironment; D015854:Up-Regulation
chemical_list: D016207:Cytokines; D035683:MicroRNAs; D018125:Receptors, Transforming Growth Factor beta; D051785:Smad Proteins; D016212:Transforming Growth Factor beta
keywords: Cancer; Inflammatory microenvironment; MicroRNA; TGF-β signaling