title: Integrin-mediated adhesion as self-sustained waves of enzymatic activation.
abstract: Integrin receptors mediate interaction between the cellular actin-cytoskeleton and extracellular matrix. Based on their activation properties, we propose a reaction-diffusion model where the kinetics of the two-state receptors is modulated by their lipidic environment. This environment serves as an activator variable, while a second variable plays the role of a scaffold protein and controls the self-sustained activation of the receptors. Due to receptor diffusion which couples dynamically the activator and the inhibitor, our model connects major classes of reaction diffusion systems for excitable media. Spot and rosette solutions, characterized by receptor clustering into localized static or dynamic structures, are organized into a phase diagram. It is shown that diffusion and kinetics of receptors determines the dynamics and the stability of these structures. We discuss this model as a precursor model for cell signaling in the context of podosomes forming actoadhesive metastructures, and we study how generic signaling defects influence their organization.
authors.affiliation: Chromatine and Epigenetics, Institut Albert Bonniot, INSERM-CNRS U823, 38042 Grenoble Cedex, France.|Dysad, Institut Albert Bonniot, INSERM-CNRS U823, Université Joseph Fourier, 38042 Grenoble Cedex, France.
authors.forename: M R
authors.initials: MR
authors.lastname: Block
authors.affiliation: Dysad, Institut Albert Bonniot, INSERM-CNRS U823, Université Joseph Fourier, 38042 Grenoble Cedex, France.
authors.forename: O
authors.initials: O
authors.lastname: Destaing
authors.affiliation: Dysad, Institut Albert Bonniot, INSERM-CNRS U823, Université Joseph Fourier, 38042 Grenoble Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Petropoulos
authors.affiliation: Dysad, Institut Albert Bonniot, INSERM-CNRS U823, Université Joseph Fourier, 38042 Grenoble Cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Planus
authors.affiliation: Dysad, Institut Albert Bonniot, INSERM-CNRS U823, Université Joseph Fourier, 38042 Grenoble Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Albigès-Rizo
authors.affiliation: Dysad, Institut Albert Bonniot, INSERM-CNRS U823, Université Joseph Fourier, 38042 Grenoble Cedex, France.|Laboratoire Joliot Curie, CNRS Ens-Lyon, 46 allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: B
authors.initials: B
authors.lastname: Fourcade
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D003198:Computer Simulation; D004058:Diffusion; D004789:Enzyme Activation / Q000502:physiology*; D016023:Integrins / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D013269:Stochastic Processes
chemical_list: D016023:Integrins