title: [Transcranial direct current stimulation for depressive disorders].
abstract: Major depressive disorders are one of the most prevalent psychiatric disorders worldwide but approximately 20-30 % of patients do not respond to standard guideline conform treatment. Recent neuroimaging studies in depressive patients revealed altered activation patterns in prefrontal brain areas and that successful cognitive behavioral therapy and psychopharmacological interventions are associated with a reversal of these neural alterations. Therefore, a direct modulation of prefrontal brain activation by non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS) seems to be a promising and innovative approach for the treatment of depressive disorders. In addition, recent neuropsychological findings indicated an augmentation of positive tDCS effects by simultaneous external activation of the stimulated brain area, for example by cognitive training tasks. Based on these findings, the possibility to augment cognitive-emotional learning processes during cognitive behavioral therapy by simultaneous tDCS to increase antidepressive therapeutic effects is discussed in this article.
authors.affiliation: Center for Affective Sciences, Klinik für Psychiatrie und Psychotherapie, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Deutschland. aust.sabine@charite.de.
authors.forename: S
authors.initials: S
authors.lastname: Aust
authors.affiliation: Sektion für Psychosomatische Medizin und Psychotherapie und Munich Center for Brain Stimulation, Klinik für Psychiatrie und Psychotherapie, LMU Klinikum der Universität München, München, Deutschland.
authors.forename: U
authors.initials: U
authors.lastname: Palm
authors.affiliation: Sektion für Psychosomatische Medizin und Psychotherapie und Munich Center for Brain Stimulation, Klinik für Psychiatrie und Psychotherapie, LMU Klinikum der Universität München, München, Deutschland.
authors.forename: F
authors.initials: F
authors.lastname: Padberg
authors.affiliation: Center for Affective Sciences, Klinik für Psychiatrie und Psychotherapie, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Bajbouj
mesh_terms: D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000628:therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D065908:Transcranial Direct Current Stimulation / Q000379:methods*; D050781:Transcranial Magnetic Stimulation / Q000639:trends*; D016896:Treatment Outcome
keywords: Cognitive behavioral therapy; Depression; Dorsolateral prefrontal cortex; Psychotherapy; Transcranial direct current stimulation