title: In vitro testing of thiolated poly(aspartic acid) from ophthalmic formulation aspects.
abstract: Ocular drug delivery formulations must meet anatomical, biopharmaceutical, patient-driven and regulatory requirements. Mucoadhesive polymers can serve as a better alternative to currently available ophthalmic formulations by providing improved bioavailability. If all requirements are addressed, a polymeric formulation resembling the tear film of the eye might be the best solution. The optimum formulation must not have high osmotic activity, should provide appropriate surface tension, pH and refractive index, must be non-toxic and should be transparent and mucoadhesive. We would like to highlight the importance of in vitro polymer testing from a pharmaceutical aspect. We, therefore, carried out physical-chemical investigations to verify the suitability of certain systems for ophthalmic formulations. In this work, in situ gelling, mucoadhesive thiolated poly(aspartic acid)s were tested from ophthalmic formulation aspects. The results of preformulation measurements indicate that these polymers can be used as potential carriers in ophthalmic drug delivery.
authors.affiliation: a Department of Pharmaceutical Technology , Faculty of Pharmacy, University of Szeged , Szeged , Hungary ;
authors.forename: Mária
authors.initials: M
authors.lastname: Budai-Szű Cs
authors.affiliation: a Department of Pharmaceutical Technology , Faculty of Pharmacy, University of Szeged , Szeged , Hungary ;
authors.forename: Gabriella
authors.initials: G
authors.lastname: Horvát
authors.affiliation: b Soft Matters Group, Department of Physical Chemistry and Materials Science , Budapest University of Technology and Economics , Budapest , Hungary ;
authors.forename: Benjámin
authors.initials: B
authors.lastname: Gyarmati
authors.affiliation: b Soft Matters Group, Department of Physical Chemistry and Materials Science , Budapest University of Technology and Economics , Budapest , Hungary ;
authors.forename: Barnabás Áron
authors.initials: BÁ
authors.lastname: Szilágyi
authors.affiliation: b Soft Matters Group, Department of Physical Chemistry and Materials Science , Budapest University of Technology and Economics , Budapest , Hungary ;
authors.forename: András
authors.initials: A
authors.lastname: Szilágyi
authors.affiliation: a Department of Pharmaceutical Technology , Faculty of Pharmacy, University of Szeged , Szeged , Hungary ;
authors.forename: Tímea
authors.initials: T
authors.lastname: Csihi
authors.affiliation: a Department of Pharmaceutical Technology , Faculty of Pharmacy, University of Szeged , Szeged , Hungary ;
authors.forename: Szilvia
authors.initials: S
authors.lastname: Berkó
authors.affiliation: a Department of Pharmaceutical Technology , Faculty of Pharmacy, University of Szeged , Szeged , Hungary ;
authors.forename: Piroska
authors.initials: P
authors.lastname: Szabó-Révész
authors.affiliation: c Department of Drug Sciences , Faculty of Pharmacy, University of Pavia , Pavia , Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Mori
authors.affiliation: c Department of Drug Sciences , Faculty of Pharmacy, University of Pavia , Pavia , Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Sandri
authors.affiliation: c Department of Drug Sciences , Faculty of Pharmacy, University of Pavia , Pavia , Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Bonferoni
authors.affiliation: c Department of Drug Sciences , Faculty of Pharmacy, University of Pavia , Pavia , Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Caramella
authors.affiliation: a Department of Pharmaceutical Technology , Faculty of Pharmacy, University of Szeged , Szeged , Hungary ;
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Csányi
mesh_terms: D000268:Adhesiveness; D000818:Animals; D001224:Aspartic Acid / Q000737:chemistry* / Q000378:metabolism; D001682:Biological Availability; D002460:Cell Line; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D005123:Eye / Q000378:metabolism*; D005782:Gels / Q000737:chemistry; D009883:Ophthalmic Solutions / Q000737:chemistry* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D011817:Rabbits; D012212:Rheology / Q000379:methods; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D005782:Gels; D009883:Ophthalmic Solutions; D011108:Polymers; D013438:Sulfhydryl Compounds; D001224:Aspartic Acid
keywords: Cytotoxicity; mucoadhesion; ocular drug delivery; pharmaceutical preformulation; rheology; thiolated polymer