title: Integration of Light and Photoperiodic Signaling in Transcriptional Nuclear Foci.
abstract: Light regulates major plant developmental transitions by orchestrating a series of nuclear events. This study uncovers the molecular function of the natural variant, TZP (Tandem Zinc-finger-Plus3), as a signal integrator of light and photoperiodic pathways in transcriptional nuclear foci. We report that TZP acts as a positive regulator of photoperiodic flowering via physical interactions with the red-light receptor phytochrome B (phyB). We demonstrate that TZP localizes in dynamic nuclear domains regulated by light quality and photoperiod. This study shows that phyB is indispensable not only for localizing TZP to transcriptionally active nuclear photobodies, but also for recruiting TZP on the promoter of the floral inducer FLOWERING LOCUS T (FT). Our findings signify a unique transcriptional regulatory role to the highly enigmatic plant nuclear photobodies, where TZP directly activates FT gene expression and promotes flowering.
authors.affiliation: Howard Hughes Medical Institute and Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address: eirini.kaiserli@glasgow.ac.uk.
authors.forename: Eirini
authors.initials: E
authors.lastname: Kaiserli
authors.affiliation: Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Katalin
authors.initials: K
authors.lastname: Páldi
authors.affiliation: Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Liz
authors.initials: L
authors.lastname: O'Donnell
authors.affiliation: Howard Hughes Medical Institute and Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Batalov
authors.affiliation: Howard Hughes Medical Institute and Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Ullas V
authors.initials: UV
authors.lastname: Pedmale
authors.affiliation: Center for Chronobiology, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Dmitri A
authors.initials: DA
authors.lastname: Nusinow
authors.affiliation: Center for Chronobiology, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Steve A
authors.initials: SA
authors.lastname: Kay
authors.affiliation: Howard Hughes Medical Institute and Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: chory@salk.edu.
authors.forename: Joanne
authors.initials: J
authors.lastname: Chory
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D018506:Gene Expression Regulation, Plant / Q000502:physiology*; D008027:Light; D017440:Photoperiod; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D029681:Arabidopsis Proteins; D014157:Transcription Factors