title: A prospective study of plasma 25-hydroxyvitamin D concentration and prostate cancer risk.
abstract: Mechanistic hypotheses suggest that vitamin D and the closely related parathyroid hormone (PTH) may be involved in prostate carcinogenesis. However, epidemiological evidence is lacking for PTH and inconsistent for vitamin D. Our objectives were to prospectively investigate the association between vitamin D status, vitamin D-related gene polymorphisms, PTH and prostate cancer risk. A total of 129 cases diagnosed within the Supplémentation en Vitamines et Minéraux Antioxydants cohort were included in a nested case-control study and matched to 167 controls (13 years of follow-up). 25-Hydroxyvitamin D (25(OH)D) and PTH concentrations were assessed from baseline plasma samples. Conditional logistic regression models were computed. Higher 25(OH)D concentration was associated with decreased risk of prostate cancer (ORQ4 v. Q1 0·30; 95 % CI 0·12, 0·77; P trend=0·007). PTH concentration was not associated with prostate cancer risk (P trend=0·4) neither did the studied vitamin D-related gene polymorphisms. In this prospective study, prostate cancer risk was inversely associated with 25(OH)D concentration but not with PTH concentration. These results bring a new contribution to the understanding of the relationship between vitamin D and prostate cancer, which deserves further investigation.
authors.affiliation: 1Sorbonne Paris Cité Epidemiology and Statistics Research Center,Inserm U1153,INRA U1125,Conservatoire National des Arts et Métiers (CNAM),Nutritional Epidemiology Research Team (EREN),Paris 13 University,93017 Bobigny,France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Deschasaux
authors.affiliation: 2Physiology Department,Necker Hospital,Inserm U845,75015 Paris,France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Souberbielle
authors.affiliation: 1Sorbonne Paris Cité Epidemiology and Statistics Research Center,Inserm U1153,INRA U1125,Conservatoire National des Arts et Métiers (CNAM),Nutritional Epidemiology Research Team (EREN),Paris 13 University,93017 Bobigny,France.
authors.forename: Paule
authors.initials: P
authors.lastname: Latino-Martel
authors.affiliation: 3Biochemistry Department,Jean Verdier Hospital,Inserm U698,Paris 13 University,93140 Bondy,France.
authors.forename: Angela
authors.initials: A
authors.lastname: Sutton
authors.affiliation: 3Biochemistry Department,Jean Verdier Hospital,Inserm U698,Paris 13 University,93140 Bondy,France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Charnaux
authors.affiliation: 1Sorbonne Paris Cité Epidemiology and Statistics Research Center,Inserm U1153,INRA U1125,Conservatoire National des Arts et Métiers (CNAM),Nutritional Epidemiology Research Team (EREN),Paris 13 University,93017 Bobigny,France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Druesne-Pecollo
authors.affiliation: 1Sorbonne Paris Cité Epidemiology and Statistics Research Center,Inserm U1153,INRA U1125,Conservatoire National des Arts et Métiers (CNAM),Nutritional Epidemiology Research Team (EREN),Paris 13 University,93017 Bobigny,France.
authors.forename: Pilar
authors.initials: P
authors.lastname: Galan
authors.affiliation: 1Sorbonne Paris Cité Epidemiology and Statistics Research Center,Inserm U1153,INRA U1125,Conservatoire National des Arts et Métiers (CNAM),Nutritional Epidemiology Research Team (EREN),Paris 13 University,93017 Bobigny,France.
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
authors.affiliation: 5Conservatoire National des Arts et Métiers (CNAM),Genomics,Bioinformatics and Applications Team (EA4627),75003 Paris,France.
authors.forename: Sigrid
authors.initials: S
authors.lastname: Le Clerc
authors.affiliation: 1Sorbonne Paris Cité Epidemiology and Statistics Research Center,Inserm U1153,INRA U1125,Conservatoire National des Arts et Métiers (CNAM),Nutritional Epidemiology Research Team (EREN),Paris 13 University,93017 Bobigny,France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Kesse-Guyot
authors.affiliation: 1Sorbonne Paris Cité Epidemiology and Statistics Research Center,Inserm U1153,INRA U1125,Conservatoire National des Arts et Métiers (CNAM),Nutritional Epidemiology Research Team (EREN),Paris 13 University,93017 Bobigny,France.
authors.forename: Khaled
authors.initials: K
authors.lastname: Ezzedine
authors.affiliation: 1Sorbonne Paris Cité Epidemiology and Statistics Research Center,Inserm U1153,INRA U1125,Conservatoire National des Arts et Métiers (CNAM),Nutritional Epidemiology Research Team (EREN),Paris 13 University,93017 Bobigny,France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Touvier
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004311:Double-Blind Method; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010919:Placebos; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000097:blood* / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics; D047488:Retinoid X Receptors / Q000235:genetics; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000235:genetics
chemical_list: D010281:Parathyroid Hormone; D010919:Placebos; D018167:Receptors, Calcitriol; D047488:Retinoid X Receptors; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 1; 25(OH)2D 1; 25(OH)D 25-hydroxyvitamin D; 25-Hydroxyvitamin D; 25-dihydroxyvitamin D; 25-dihydroxyvitamin D3 24-hydroxylase; CYP24A1
                  1; CaSR
                  Ca-sensing receptor; GC
                  vitamin D-binding globulin; MAF minor allele frequency; Nested case–control studies; PTH parathyroid hormone; Parathyroid hormone; Prostate cancer risk; RXR
                  retinoid X receptor; SNP; SU.VI.MAX Supplémentation en Vitamines et Minéraux Antioxydants; VDR
                  vitamin D receptor; gc-globulin or group-specific component