title: Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions.
abstract: A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice.
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, MI.
authors.forename: Deanna M
authors.initials: DM
authors.lastname: Arble
authors.affiliation: Department of Medicine, Endocrinology Division, Feinberg School of Medicine, Northwestern University, Chicago, IL.
authors.forename: Joseph
authors.initials: J
authors.lastname: Bass
authors.affiliation: Department of Applied Mathematics & Statistics, Colorado School of Mines, Golden, CO.
authors.forename: Cecilia Diniz
authors.initials: CD
authors.lastname: Behn
authors.affiliation: Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Butler
authors.affiliation: Institute for Cellular and Integrative Neuroscience, CNRS, University of Strasbourg, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Challet
authors.affiliation: Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Charles
authors.initials: C
authors.lastname: Czeisler
authors.affiliation: Department of Integrative Physiology, University of Colorado, Boulder, CO.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Depner
authors.affiliation: Departments of Internal Medicine, Pharmacology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Joel
authors.initials: J
authors.lastname: Elmquist
authors.affiliation: Center for Integrative Genomics, University of Lausanne, Switzerland.
authors.forename: Paul
authors.initials: P
authors.lastname: Franken
authors.affiliation: Department of Psychiatry, University of Arizona, Tucson, AZ.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Grandner
authors.affiliation: Department of Medicine, The University of Chicago, Chicago, IL.
authors.forename: Erin C
authors.initials: EC
authors.lastname: Hanlon
authors.affiliation: Department of Biology, University of Nevada, Reno, NV.
authors.forename: Alex C
authors.initials: AC
authors.lastname: Keene
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Joyner
authors.affiliation: Department of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA.
authors.forename: Ilia
authors.initials: I
authors.lastname: Karatsoreos
authors.affiliation: Department of Medicine, Division of Endocrinology and Center for Clinical and Translational Sciences, University of Kentucky, Lexington, KY.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Kern
authors.affiliation: Center for Human Nutrition, Washington University School of Medicine in St. Louis, St. Louis, MO.
authors.forename: Samuel
authors.initials: S
authors.lastname: Klein
authors.affiliation: Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Morris
authors.affiliation: Division of Sleep Medicine/Department of Medicine and Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
authors.forename: Allan I
authors.initials: AI
authors.lastname: Pack
authors.affiliation: Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
authors.forename: Satchidananda
authors.initials: S
authors.lastname: Panda
authors.affiliation: Department of Neurology, Howard Hughes Medical Institute, University of California, San Francisco, CA.
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Ptacek
authors.affiliation: Department of Medicine, The Johns Hopkins University, Baltimore, MD.
authors.forename: Naresh M
authors.initials: NM
authors.lastname: Punjabi
authors.affiliation: Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Sassone-Corsi
authors.affiliation: Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA.
authors.forename: Frank A
authors.initials: FA
authors.lastname: Scheer
authors.affiliation: Department of Anesthesia, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Richa
authors.initials: R
authors.lastname: Saxena
authors.affiliation: Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN.
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Seaquest
authors.affiliation: Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Thimgan
authors.affiliation: Sleep, Metabolism and Health Center, The University of Chicago, Chicago, IL.
authors.forename: Eve
authors.initials: E
authors.lastname: Van Cauter
authors.affiliation: Department of Integrative Physiology, University of Colorado, Boulder, CO.|Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO.
authors.forename: Kenneth P
authors.initials: KP
authors.lastname: Wright
mesh_terms: D017668:Age of Onset; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology*; D058068:Endophenotypes; D004734:Energy Metabolism; D005215:Fasting / Q000378:metabolism; D005508:Food Deprivation; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism; D051379:Mice; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000628:therapy; D020178:Sleep Disorders, Circadian Rhythm / Q000378:metabolism / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D007328:Insulin; D005947:Glucose
keywords: circadian disruption; circadian rhythm; diabetes; insulin resistance; metabolism; obesity; short sleep; sleep apnea; sleep disorders