title: Cell Therapy for Intracranial Aneurysms: A Review.
abstract: One in five patients undergoing endovascular coiling (the current standard of care for treating intracranial aneurysms) experience a recurrence of the aneurysm as a result of improper healing. Recurrence remains the only major drawback of the coiling treatment and has been the focus of many studies over the last two decades. Cell therapy, a novel treatment modality in which therapeutic cells are introduced to the site of the injury to promote tissue regeneration, has opened up new possibilities for treating aneurysms. The healing response that ensues aneurysm embolization includes several cellular processes that can be targeted with cell therapy to prevent the aneurysm from recurring. Ten preclinical studies involving cell therapy to treat aneurysms were published between 1999 and 2014. In this review, we summarize the results of these studies and discuss advances, shortcomings, and the future of cell therapy for intracranial aneurysms.
authors.affiliation: Pharmaceutical Production Research Facility (PPRF), Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada; Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Amin
authors.initials: A
authors.lastname: Adibi
authors.affiliation: Pharmaceutical Production Research Facility (PPRF), Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Arindom
authors.initials: A
authors.lastname: Sen
authors.affiliation: Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada. Electronic address: amitha@ucalgary.ca.
authors.forename: Alim P
authors.initials: AP
authors.lastname: Mitha
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D004621:Embolization, Therapeutic; D057510:Endovascular Procedures; D006801:Humans; D002532:Intracranial Aneurysm / Q000209:etiology / Q000473:pathology / Q000628:therapy*
keywords: Aneurysm recurrence; Cell therapy; Endovascular coiling; Intracranial aneurysms; Stem cells