title: Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells.
abstract: A series of butylphthalide derivatives (BPDs) 1-8 were isolated from the extract of the dried rhizome of Ligusticum chuanxiong Hort. (Umbelliferae). The cytotoxic activities of BPDs 1-8 were evaluated using a panel of human cancer cell lines. In addition, the SAR analysis and potential anti-invasion activities were investigated. The sp² carbons at C-7 and C-7a appeared to be essential for the cytotoxic activities of BPDs. BPDs 5 and 6 remarkably inhibited the migration and invasion of cancer cells. The anti-invasion activity of dimer 6 was demonstrated to be significantly higher than monomer 5.
authors.affiliation: Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110001, China. huyihank@hotmail.com.
authors.forename: Yihan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China. xiaoxu.bi@hotmail.com.
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Bi
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China. zhaopu6687700@163.com.
authors.forename: Pu
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Cancer Research Center, Key Laboratory of Brain and Spinal Cord Injury of Liaoning Province, and Laboratory Animal Center, the First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China. zheng_huachuan@hotmail.com.
authors.forename: Huachuan
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110001, China. huangxs@mail.neu.edu.cn.|Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China. huangxs@mail.neu.edu.cn.
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D006528:Carcinoma, Hepatocellular; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D010936:Plant Extracts; C027125:3-n-butylphthalide
keywords: Ligusticum chuanxiong; SAR; anti-invasion; butylphthalides; cytotoxic activity