title: Sjögren's syndrome-associated interstitial lung disease: A multicenter study.
abstract: Primary Sjögren syndrome (PSS) is a chronic inflammatory autoimmune disease. Interstitial lung disease (ILD) can be an extraglandular complication.
  
  
  OBJECTIVE
  To evaluate the clinical characteristics of patients diagnosed with PSS with ILD.
  
  
  METHODS
  Multicentre cohort study with 25 patients diagnosed with PSS and ILD. Data of PSS, prognostic factors, pulmonary involvement variables, complementary tests that suggest a worse diagnosis and treatment given were collected. EULAR index was measured for Sjögren's syndrome.
  
  
  RESULTS
  We identified 25 patients. In 15/25 the diagnosis of ILD was done before the diagnosis of PSS. The histopathological patterns found were: 12 NSIP, 5 UIP, 4 OP, 2 LIP. PFRs showed restrictive pattern. The majority of the patients received glucocorticoid therapy, antimalarial or immunosuppressive treatment.
  
  
  CONCLUSIONS
  Patients affected with PSS must be screened to catch a precocious diagnosis of ILD. The majority of the patients were diagnosed of ILD before being diagnosed of PSS. Multicenter cohorts are increasingly demanded and a multidisciplinary management is needed.
authors.affiliation: Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain. Electronic address: deliareinasanz@gmail.com.
authors.forename: Delia
authors.initials: D
authors.lastname: Reina
authors.affiliation: Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Roig Vilaseca
authors.affiliation: Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain.
authors.forename: Vicenç
authors.initials: V
authors.lastname: Torrente-Segarra
authors.affiliation: Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain.
authors.forename: Dacia
authors.initials: D
authors.lastname: Cerdà
authors.affiliation: Servicio de Reumatología, Hospital de Sant Pau, Spain.
authors.forename: Ivan
authors.initials: I
authors.lastname: Castellví
authors.affiliation: Servicio de Reumatología, Hospital de Sant Pau, Spain.
authors.forename: Cèsar
authors.initials: C
authors.lastname: Díaz Torné
authors.affiliation: Servicio de Reumatología, Hospital Parc Taulí, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Moreno
authors.affiliation: Servicio de Reumatología, Hospital de Bellvitge, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Narváez
authors.affiliation: Servicio de Reumatología, Hospital de Granollers, Spain.
authors.forename: Vera
authors.initials: V
authors.lastname: Ortiz
authors.affiliation: Servicio de Neumología, Hospital Sant Joan Despí Moisès Broggi, Spain.
authors.forename: Rosana
authors.initials: R
authors.lastname: Blavia
authors.affiliation: Clinical Epidemiology Department, Consorci Sanitari Integral, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Martín-Baranera
authors.affiliation: Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain.
authors.forename: Hèctor
authors.initials: H
authors.lastname: Corominas
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
keywords: Enfermedad pulmonar intersticial; Interstitial lung disease; Sjögren syndrome; Síndrome de Sjögren