title: Dissipation in noisy chemical networks: The role of deficiency.
abstract: We study the effect of intrinsic noise on the thermodynamic balance of complex chemical networks subtending cellular metabolism and gene regulation. A topological network property called deficiency, known to determine the possibility of complex behavior such as multistability and oscillations, is shown to also characterize the entropic balance. In particular, when deficiency is zero the average stochastic dissipation rate equals that of the corresponding deterministic model, where correlations are disregarded. In fact, dissipation can be reduced by the effect of noise, as occurs in a toy model of metabolism that we employ to illustrate our findings. This phenomenon highlights that there is a close interplay between deficiency and the activation of new dissipative pathways at low molecule numbers.
authors.affiliation: Complex Systems and Statistical Mechanics, Physics and Materials Science Research Unit, University of Luxembourg, 162a Avenue de la Faïencerie, Luxembourg L-1511, Luxembourg.
authors.forename: M
authors.initials: M
authors.lastname: Polettini
authors.affiliation: Complex Systems and Statistical Mechanics, Physics and Materials Science Research Unit, University of Luxembourg, 162a Avenue de la Faïencerie, Luxembourg L-1511, Luxembourg.
authors.forename: A
authors.initials: A
authors.lastname: Wachtel
authors.affiliation: Complex Systems and Statistical Mechanics, Physics and Materials Science Research Unit, University of Luxembourg, 162a Avenue de la Faïencerie, Luxembourg L-1511, Luxembourg.
authors.forename: M
authors.initials: M
authors.lastname: Esposito
mesh_terms: D013269:Stochastic Processes; D013816:Thermodynamics