title: Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study.
abstract: OBJECTIVE
  To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant.
  
  
  METHODS
  Data are from a prospective cohort in Cincinnati, Ohio (HOME Study). Perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids were measured in prenatal serum samples. Differences were measured in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n = 204) and BMI between 2-8 years of age (n = 285) according to PFAS concentrations.
  
  
  RESULTS
  Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI: 1.7, 6.9) and 3rd tercile (2.2; 95% CI: -0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2 to 8 years compared to children in the 1st tercile (P < 0.05). PFOS, PFNA, and PFHxS were not associated with adiposity.
  
  
  CONCLUSIONS
  In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2-8 years.
authors.affiliation: Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, Rhode Island, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Braun
authors.affiliation: Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA.
authors.forename: Aimin
authors.initials: A
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, Rhode Island, USA.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Romano
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Calafat
authors.affiliation: Child and Family Research Institute, BC Children's and Women's Hospital, Vancouver, British Columbia, Canada.|Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
authors.forename: Glenys M
authors.initials: GM
authors.lastname: Webster
authors.affiliation: Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Yolton
authors.affiliation: Child and Family Research Institute, BC Children's and Women's Hospital, Vancouver, British Columbia, Canada.|Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Lanphear
mesh_terms: D000328:Adult; D017738:Alkanesulfonic Acids / Q000009:adverse effects*; D002210:Caprylates / Q000009:adverse effects*; D002648:Child; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids; D005260:Female; D005466:Fluorocarbons / Q000009:adverse effects*; D006801:Humans; D008137:Longitudinal Studies; D009820:Ohio; D063766:Pediatric Obesity / Q000139:chemically induced*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013451:Sulfonic Acids / Q000009:adverse effects*; D055105:Waist Circumference
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D005227:Fatty Acids; D005466:Fluorocarbons; D013451:Sulfonic Acids; C471071:perfluorohexanesulfonic acid; C101816:perfluoro-n-nonanoic acid; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid