title: New onset diabetes after kidney transplantation in patients with autosomal dominant polycystic kidney disease: systematic review protocol.
abstract: BACKGROUND
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder with numerous cysts developing in bilateral kidneys. Meanwhile, ADPKD can also be regarded as a systemic disease because the cystic and non-cystic abnormalities could be identified in multiple organs in patients with ADPKD. Several lines of evidence suggest the risk of post-transplant diabetes mellitus or new-onset diabetes after transplantation (NODAT) is higher in patients with ADPKD compared with non-ADPKD renal recipients, but the available results are conflicting. We describe the protocol of a systematic review and meta-analysis for investigating the risk of NODAT in patients with ADPKD.
  
  
  METHODS
  PubMed, EMBASE and The Cochrane Library will be searched. Cohort studies irrespective of language and publication status, comparing the incidence of NODAT in renal recipients with ADPKD and other kidney disease will be eligible. We will assess heterogeneity among studies. Along with 95% CIs, dichotomous data will be summarised as risk ratios; numbers needed to treat/harm and continuous data will be given as standard mean differences. Excluding outliers and testing small sample size studies if our results are robust, sensitivity analysis will be carried out.
  
  
  BACKGROUND
  Ethical approval is not required because this study includes no confidential personal data or patient interventions. The review findings will be helpful in designing and implementing future studies and will be of interest to a wide range of readers, including healthcare professionals, researchers, health service managers and policymakers. The systematic review will be published in a peer-reviewed journal and disseminated electronically and in print.
  
  
  BACKGROUND
  The study protocol has been registered in PROSPERO (http://www.crd.york.ac.uk/PROSPERO/) under registration number CRD42014009677.
authors.affiliation: Division of Nephrology, Kidney Institute of CPLA, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Division of Nephrology, Kidney Institute of CPLA, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Sixiu
authors.initials: S
authors.lastname: Chen
authors.affiliation: No. 1 Cadets Company, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Division of Nephrology, Kidney Institute of CPLA, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Changlin
authors.initials: C
authors.lastname: Mei
authors.affiliation: Kidney Genetics Group, Academic Nephrology Unit, The Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, Sheffield, UK.
authors.forename: Albert
authors.initials: A
authors.lastname: Ong
authors.affiliation: Division of Nephrology, Kidney Institute of CPLA, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Mao
mesh_terms: D003920:Diabetes Mellitus / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D015201:Meta-Analysis as Topic; D016891:Polycystic Kidney, Autosomal Dominant / Q000601:surgery*; D011183:Postoperative Complications; D012107:Research Design; D000078202:Systematic Reviews as Topic
keywords: Diabetes Mellitus; Kidney Transplantation; Polycystic Kidney, Autosomal Dominant