title: An unprecedented Pd-catalyzed decarboxylative coupling reaction of aromatic carboxylic acids in aqueous medium under air: synthesis of 3-aryl-imidazo[1,2-a]pyridines from aryl chlorides.
abstract: An efficient and practical protocol for palladium-catalyzed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with aryl chlorides has been developed. Note that the reaction could proceed smoothly without an additive in aqueous medium under an ambient atmosphere, and the addition of H2O could effectively promote the decarboxylative arylation. Particularly noteworthy is that these results represent the first examples of Pd-catalyzed decarboxylative coupling reactions of (hetero) aromatic carboxylic acids in aqueous medium under air, and the first successful examples of the synthesis of 3-aryl-imidazo[1,2-a]pyridines using cheap, diverse aryl chlorides and heteroaryl chlorides as the starting materials.
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, PR China. yusheng.wu@tetranovglobal.com and The College of Chemistry and Chemical Engineering, Zhengzhou Normal University, Zhengzhou 450044, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Mu
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, PR China. yusheng.wu@tetranovglobal.com and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China and Tetranov Biopharm, LLC, 75 Daxue Road, Zhengzhou, PR China.
authors.forename: Jingya
authors.initials: J
authors.lastname: Li
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, PR China. yusheng.wu@tetranovglobal.com.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Zou
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, PR China. yusheng.wu@tetranovglobal.com.
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
authors.affiliation: The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, PR China. yusheng.wu@tetranovglobal.com.
authors.forename: Yangjie
authors.initials: Y
authors.lastname: Wu