title: Fundus autofluorescence in central serous chorioretinopathy: association with spectral-domain optical coherence tomography and fluorescein angiography.
abstract: OBJECTIVE
  To evaluate the correlation among changes in fundus autofluorescence (AF) measured using infrared fundus AF (IR-AF) and short-wave length fundus AF (SW-AF) with changes in spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in central serous chorioretinopathy (CSC).
  
  
  METHODS
  Two hundred and twenty consecutive patients with CSC were included. In addition to AF, patients were assessed by means of SD-OCT and FA. Abnormalities in images of IR-AF, SW-AF, FA were analyzed and correlated with the corresponding outer retinal alterations in SD-OCT findings.
  
  
  RESULTS
  Eyes with abnormalities on either IR-AF or SW-AF were found in 256 eyes (58.18%), among them 256 eyes (100%) showed abnormal IR-AF, but SW-AF abnormalities were present only in 213 eyes (83.20%). The hypo-IR-AF corresponded to accumulation of sub-retinal liquid, collapse of retinal pigment epithelium (RPE) or detachment of RPE with or without RPE leakage point in the corresponding area. The hyper-IR-AF corresponded to the area with loss of the ellipsoid portion of the inner segments and sub-sensory retinal deposits or focal melanogenesis under sensory retina. The hypo-SW-AF corresponded to accumulation of sub-retinal liquid or atrophy of RPE. The hyper-SW-AF associated with sub-sensory retinal deposits, detachment of RPE and focal melanogenesis.
  
  
  CONCLUSIONS
  IR-AF was more sensitive than SW-AF and FA for identifying pathological abnormalities in CSC. The characteristics of IR-AF in CSC were attributable to the modification of melanin in the RPE. IR-AF should be used as a common diagnostic tool for identifying pathological lesion in CSC.
authors.affiliation: Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China.
authors.forename: Zi-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China.
authors.forename: Dong-Jie
authors.initials: DJ
authors.lastname: Sun
authors.affiliation: Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China.
authors.forename: Jin-Ting
authors.initials: JT
authors.lastname: Zhu
authors.affiliation: Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China.
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Wang
keywords: central serous chorioretinopathy; fluorescein angiography; fundus autofluorescence; optical coherence tomography