title: Studies on methylcellulose/pectin/montmorillonite nanocomposite films and their application possibilities.
abstract: Films based on methylcellulose (MC) and pectin (PEC) of different ratios were prepared. MC/PEC (90:10) (MP10) gave the best results in terms of mechanical properties. Sodium montmorillonite (MMT) (1, 3 and 5 wt%) was incorporated in the MP10 matrix. The resulting films were characterized by X-ray diffraction and transmission electron microscopy, and it was found that nanocomposites were intercalated in nature. Mechanical studies established that addition of 3 wt% MMT gave best results in terms of mechanical properties. However, thermo-gravimetric and dynamic mechanical analysis proved that decomposition and glass transition temperature increased with increasing MMT concentration from 1 to 5 wt%. It was also observed that moisture absorption and water vapor permeability studies gave best result in the case of 3 wt% MMT. Optical clarity of the nanocomposite films was not much affected with loading of MMT. In vitro drug release studies showed that MC/PEC/MMT based films can be used for controlled transdermal drug delivery applications.
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India.
authors.forename: Nayan Ranjan
authors.initials: NR
authors.lastname: Saha
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India.
authors.forename: Gunjan
authors.initials: G
authors.lastname: Sarkar
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India.
authors.forename: Indranil
authors.initials: I
authors.lastname: Roy
authors.affiliation: Department of Chemical and Biological Engineering, Industrial Membrane Research Institute, University of Ottawa, 161 Louis Pasteur St. , Ottawa, ON K1N 6N5, Canada.
authors.forename: Dipak
authors.initials: D
authors.lastname: Rana
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India.
authors.forename: Amartya
authors.initials: A
authors.lastname: Bhattacharyya
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India.
authors.forename: Arpita
authors.initials: A
authors.lastname: Adhikari
authors.affiliation: Department of Jute and Fiber Technology, Institute of Jute Technology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700019, India.
authors.forename: Asis
authors.initials: A
authors.lastname: Mukhopadhyay
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India. Electronic address: dipankar.chattopadhyay@gmail.com.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Chattopadhyay
mesh_terms: D001546:Bentonite / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006801:Humans; D020911:Ketorolac Tromethamine / Q000737:chemistry; D055595:Mechanical Phenomena; D008747:Methylcellulose / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D010368:Pectins / Q000737:chemistry*; D044367:Phase Transition; D019064:Product Packaging; D012867:Skin; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D014835:Volatilization; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D012997:Solvents; D014867:Water; D001546:Bentonite; D020911:Ketorolac Tromethamine; D010368:Pectins; D008747:Methylcellulose
keywords: Mechanical properties; Methylcellulose; Montmorillonite; Nanocomposites; Pectin; Transdermal drug delivery