title: Bromocriptine mitigated paliperidone metabolic and neuro-hormonal side effects and improved negative domain in a case of early onset schizophrenia.
abstract: We report a case of early onset schizophrenia that responded favourably to paliperidone but experienced hyperprolactinaemia, tremors, and weight gain, with impaired fasting glycaemia. Addition of bromocriptine helped with both hyperprolactinaemia and tremors, but also brought about euglycaemia and, strikingly, ameliorated negative symptoms.
authors.affiliation: a Department of Child and Adolescent Psychiatry , Kuwait Centre for Mental Health , Kuwait ;
authors.forename: Ahmed
authors.initials: A
authors.lastname: Naguy
authors.affiliation: b Neuromodulation Unit, Department of General Adult Psychiatry , Kuwait Centre for Mental Health , Kuwait.
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Tajali
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001971:Bromocriptine / Q000627:therapeutic use*; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D000068882:Paliperidone Palmitate / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*; D016896:Treatment Outcome; D014202:Tremor / Q000139:chemically induced / Q000188:drug therapy*; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D001971:Bromocriptine; D000068882:Paliperidone Palmitate
keywords: Bromocriptine; Hyperprolactinaemia; Metabolic syndrome; Negative domain; Paliperidone; Schizophrenia.