title: Green synthesis, characterization and drug delivery applications of a novel silver/carboxymethylcellulose - poly(acrylamide) hydrogel nanocomposite.
abstract: Biodegradable polymeric hydrogels are a unique class of macromolecular networks that can hold a large fraction of an aqueous solvent within their structures. They are particularly suitable for biomedical applications including controlled drug delivery, because of their ability to stimulate biological tissues. Many hydrogel-based networks have been designed and fabricated to meet the needs of pharmaceutical and medical fields. The investigation deals with the environment friendly synthesis of biodegradable semi interpenetrating hydrogel networks based on cross-linked poly(acrylamide) through an optimized rapid redox solution polymerization with N, N'Methylenebisacrylamide (MBA) in presence of Carboxymethylcellulose (CMC).The silver nanoparticles within hydrogel networks as nano reactors have been prepared by green synthesis via insitu reduction of silver nitrate (AgNO3) using Azadirachta Indica (Neem) plant extract under atmospheric conditions. The synthesized nanocomposites were characterised by FTIR spectroscopy, UV-Visible Spectroscopy, Scanning Electron Microscopy (SEM), Transmission electron microscopy (TEM) and Dynamic light scattering (DLS) technique. The thermal properties of the nanocomposite was analyzed by Thermogravimetric Analysis (TGA). The pH response and drug release profile of the synthesised biodegradable Silver-Hydrogel nanocomposite was investigated. Further, it was observed that physicochemical interaction between the polymeric nanocomposites and drug influences the degree of matrix swelling and therefore, its porosity and diffusion release process.
authors.affiliation: Department of Chemistry, Justice Basheer Ahmed Sayeed College for Women (Autonomous), Chennai 600 018, India. Electronic address: mgzaa@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Gulsonbi
authors.affiliation: Department of Chemistry, Mahalakshmi Engineering College, Trichy 621 213, India.
authors.forename: S
authors.initials: S
authors.lastname: Parthasarathy
authors.affiliation: PG and Research Department of Chemistry, Presidency College (Autonomous), Chennai 600 005, India.
authors.forename: K
authors.initials: K
authors.lastname: Bharat Raj
authors.affiliation: PG and Research Department of Chemistry, Presidency College (Autonomous), Chennai 600 005, India.
authors.forename: V
authors.initials: V
authors.lastname: Jaisankar
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry; D031601:Azadirachta; D063566:Biodegradable Plastics / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004926:Escherichia coli; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053761:Nanocomposites / Q000737:chemistry*; D010936:Plant Extracts; D016062:Porosity; D012834:Silver / Q000737:chemistry*; D012835:Silver Nitrate / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D000099166:Polyacrylamides
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D063566:Biodegradable Plastics; D002266:Carboxymethylcellulose Sodium; D020100:Hydrogels; D010936:Plant Extracts; D012834:Silver; D012835:Silver Nitrate; D000099166:Polyacrylamides; C016680:polyacrylamide gels; C021221:N,N'-methylenebisacrylamide
keywords: Drug delivery; Green synthesis; Polymeric hydrogels; Silver nanoparticles