title: [Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice].
abstract: Age-dependent angiogenesis intensity changes have been studied in transgenic HER-2/neu (FBV/N) mice characteristic of breast tumors' high incidence with hyperexpression of HER-2/neu. Concentration of vascular endothelial growth factor, insulin-dependent growth factor 1, nitrogen monoxide, tissue plasminogen activator and type 1 plasminogen activator inhibitor were assessed by means of immune-enzyme assay. The results testify to angiogenesis processes activation side by side with aging and growth of the tumors. Maximum manifestation of these disturbances (growth factors' blood concentrations increase and endotheliocytes' functional activity inhibition) has been revealed in 6-month-old mice during neoplasma maximum intensive and aggressive growth period.
authors.forename: A P
authors.initials: AP
authors.lastname: Trashkov
authors.forename: A V
authors.initials: AV
authors.lastname: Panchenko
authors.forename: R V
authors.initials: RV
authors.lastname: Korablev
authors.forename: M N
authors.initials: MN
authors.lastname: Yurova
authors.forename: P A
authors.initials: PA
authors.lastname: Egormin
authors.forename: N A
authors.initials: NA
authors.lastname: Chernenko
authors.forename: I G
authors.initials: IG
authors.lastname: Popovich
authors.forename: M L
authors.initials: ML
authors.lastname: Tyndyk
authors.forename: M R
authors.initials: MR
authors.lastname: Artemenko
authors.forename: N A
authors.initials: NA
authors.lastname: Verlov
authors.forename: A G
authors.initials: AG
authors.lastname: Vasiliev
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000098:blood supply; D000375:Aging / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015674:Mammary Neoplasms, Animal / Q000097:blood* / Q000098:blood supply; D008325:Mammary Neoplasms, Experimental; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D009389:Neovascularization, Pathologic / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D007334:Insulin-Like Growth Factor I; D009569:Nitric Oxide; D017395:Plasminogen Activator Inhibitor 1; D018719:Erb-b2 Receptor Tyrosine Kinases; D010959:Tissue Plasminogen Activator; D042461:Vascular Endothelial Growth Factor A; C519530:insulin-like growth factor-1, mouse; C467480:vascular endothelial growth factor A, mouse