title: Diet-delivered RNAi in Helicoverpa armigera--Progresses and challenges.
abstract: Helicoverpa armigera (the cotton bollworm) is a significant agricultural pest endemic to Afro-Eurasia and Oceania. Gene suppression via RNA interference (RNAi) presents a potential avenue for management of the pest, which is highly resistant to traditional insecticide sprays. This article reviews current understanding on the fate of ingested double-stranded RNA in H. armigera. Existing in vivo studies on diet-delivered RNAi and their effects are summarized and followed by a discussion on the factors and hurdles affecting the efficacy of diet-delivered RNAi in H. armigera.
authors.affiliation: Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, St Lucia, Queensland 4072, Australia.
authors.forename: Zhi Xian
authors.initials: ZX
authors.lastname: Lim
authors.affiliation: Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, St Lucia, Queensland 4072, Australia.
authors.forename: Karl E
authors.initials: KE
authors.lastname: Robinson
authors.affiliation: Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, St Lucia, Queensland 4072, Australia.
authors.forename: Ritesh G
authors.initials: RG
authors.lastname: Jain
authors.affiliation: Division of Biotechnology, Indian Institute of Horticultural Research (IIHR), Hesaraghatta Lake Post, Bengaluru 560 089, India.
authors.forename: G Sharath
authors.initials: GS
authors.lastname: Chandra
authors.affiliation: Division of Biotechnology, Indian Institute of Horticultural Research (IIHR), Hesaraghatta Lake Post, Bengaluru 560 089, India.
authors.forename: R
authors.initials: R
authors.lastname: Asokan
authors.affiliation: School of Biological Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
authors.forename: Sassan
authors.initials: S
authors.lastname: Asgari
authors.affiliation: Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, St Lucia, Queensland 4072, Australia. Electronic address: n.mitter@uq.edu.au.
authors.forename: Neena
authors.initials: N
authors.lastname: Mitter
mesh_terms: D000818:Animals; D007300:Insect Control; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D009036:Moths / Q000235:genetics* / Q000378:metabolism*; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000235:genetics / Q000378:metabolism*
chemical_list: D019476:Insect Proteins; D012330:RNA, Double-Stranded
keywords: Cotton bollworm; Diet-delivery; Helicoverpa armigera; RNA interference; RNAi; dsRNA uptake