title: What does a diagnostic label of 'polycystic ovary syndrome' really mean in adolescence? A review of current practice recommendations.
abstract: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder, with many women initially presenting during adolescence. Diagnosis during this period is particularly challenging, yet many emphasize the importance of an early diagnosis given the long-term metabolic and reproductive health consequences associated with the syndrome. The objective of this study was to review the current literature to determine whether the diagnostic label 'PCOS' is necessary to effectively manage adolescent girls presenting with features of the syndrome. A literature search was conducted (PubMed, Medline, Informit Health and the Cochrane Database of Systematic Reviews) identifying papers addressing the diagnosis and management of PCOS during adolescence. Articles were selected based on date of publication, relevance of material and the quality of evidence presented. A total of 427 papers were screened, with 40 of these selected from the initial search. A subsequent 154 were included from manual review of reference lists from key papers identified in the initial search. Current guidelines recommend treating the individual manifestations of PCOS. In doing so, there is good evidence identifying that this approach adequately targets the underlying metabolic and reproductive changes associated with the syndrome. This suggests that providing a diagnostic label of PCOS is not actually necessary to effectively manage adolescent girls with features of this syndrome.
authors.affiliation: Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Morris
authors.affiliation: Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.|Centre for Hormone Research, Murdoch Childrens Research Institute and The Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Grover
authors.affiliation: Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.|Centre for Hormone Research, Murdoch Childrens Research Institute and The Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: Sabin
mesh_terms: D000293:Adolescent; D000067697:Adolescent Health; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy
keywords: Adolescence; hyperandrogenism; obesity; polycystic ovary syndrome