title: Diagnostic approach to eosinophilic oesophagitis: Pearls and pitfalls.
abstract: Eosinophilic oesophagitis (EoE) has first been described a little over 20 years ago. EoE has been defined by a panel of international experts as a "chronic, immune/antigen-mediated, oesophageal disease, characterized clinically by symptoms related to oesophageal dysfunction and histologically by eosinophil-predominant inflammation". A value of ≥ 15 eosinophils has been defined as histologic diagnostic cutoff. Other conditions associated with oesophageal eosinophilia, such as gastro-oesophageal reflux disease (GERD), PPI-responsive oesophageal eosinophilia, or Crohn's disease should be excluded before EoE can be diagnosed. This review highlights the latest insights regarding the diagnosis and differential diagnosis of EoE.
authors.affiliation: Division of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois/CHUV, Rue de Bugnon 44, 07/2409, 1011, Lausanne, Switzerland. Electronic address: alain.schoepfer@chuv.ch.
authors.forename: Alain
authors.initials: A
authors.lastname: Schoepfer
mesh_terms: D003424:Crohn Disease / Q000175:diagnosis; D003937:Diagnosis, Differential; D057765:Eosinophilic Esophagitis / Q000175:diagnosis*; D005764:Gastroesophageal Reflux / Q000175:diagnosis; D006801:Humans
keywords: Eosinophilic oesophagitis; Eosinophils; PPI-responsive oesophageal eosinophilia