title: Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids.
abstract: A copper-mediated radiofluorination of aryl- and vinylboronic acids with K(18)F is described. This method exhibits high functional group tolerance and is effective for the radiofluorination of a range of electron-deficient, -neutral, and -rich aryl-, heteroaryl-, and vinylboronic acids. This method has been applied to the synthesis of [(18)F]FPEB, a PET radiotracer for quantifying metabotropic glutamate 5 receptors.
authors.affiliation: Department of Radiology, University of Michigan Medical School , 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Andrew V
authors.initials: AV
authors.lastname: Mossine
authors.affiliation: Department of Radiology, University of Michigan Medical School , 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Allen F
authors.initials: AF
authors.lastname: Brooks
authors.affiliation: Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
authors.forename: Katarina J
authors.initials: KJ
authors.lastname: Makaravage
authors.affiliation: Department of Medicinal Chemistry, University of Michigan , 428 Church Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Miller
authors.affiliation: Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ichiishi
authors.affiliation: Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
authors.forename: Melanie S
authors.initials: MS
authors.lastname: Sanford
authors.affiliation: Department of Radiology, University of Michigan Medical School , 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.|Department of Medicinal Chemistry, University of Michigan , 428 Church Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Peter J H
authors.initials: PJ
authors.lastname: Scott
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D049268:Positron-Emission Tomography; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C527000:3-fluoro-5-((pyridin-3-yl)ethynyl)benzonitrile; D001897:Boronic Acids; D005462:Fluorine Radioisotopes; D009570:Nitriles; D011725:Pyridines; D019275:Radiopharmaceuticals; D003300:Copper