title: [Bicyclol combined with ganciclovir for treatment of infantile cytomegalovirus hepatitis].
abstract: OBJECTIVE
  To evaluate the therapeutic effects of bicyclol combined with ganciclocir on infantile cytomegalovirus hepatitis.
  
  
  METHODS
  Seventy infants with cytomegalovirus hepatitis were randomized into treatment group (n=35) and control group (n=35) for a 2-week-long treatment with ganciclocir (5 mg/kg) with and without oral bicyclol (3 mg/kg, twice daily), respectively.
  
  
  RESULTS
  In both groups, significant changes occurred in the levels of alanine aminotransferase, alkaline phosphatase, serum total bilirubin, serum total bile acid, and glutamyl transpeptidase after the 2-week treatment (P<0.01); these parameters differed significantly between the two groups after the treatment (P<0.01). Compared with those in the control group, the infants in the treatment group showed significantly better responses to the treatment (P<0.05) with a significantly higher rate of serum anti CMV IgM negativity (P<0.05).
  
  
  CONCLUSIONS
  Bicyclol combined with ganciclocir can reduce glutamic pyruvic transaminase, alkaline phosphatase and serum total bilirubin, and decrease bile acid levels to lessen liver cell damage and promote the recovery of liver cells.
authors.affiliation: Department of Neonatology, Zhengzhou People's Hospital, Zhengzhou 450000, China. E-mail: lyhzwx@163.com.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Liu
authors.forename: Mei-Yun
authors.initials: MY
authors.lastname: Jia
authors.forename: Gui-Juan
authors.initials: GJ
authors.lastname: Liang
authors.forename: Hai-Shan
authors.initials: HS
authors.lastname: Guan
authors.forename: An-Ping
authors.initials: AP
authors.lastname: Yan
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000998:Antiviral Agents / Q000627:therapeutic use*; D001663:Bilirubin / Q000097:blood; D001713:Biphenyl Compounds / Q000627:therapeutic use*; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D015774:Ganciclovir / Q000627:therapeutic use*; D006505:Hepatitis / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007223:Infant; D008111:Liver Function Tests
chemical_list: D000998:Antiviral Agents; D001713:Biphenyl Compounds; C477843:bicyclol; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D015774:Ganciclovir; D001663:Bilirubin