title: Dual pH and temperature responsive hydrogels based on β-cyclodextrin derivatives for atorvastatin delivery.
abstract: 2-Methylacrylic acid modified β-cyclodextrin was copolymerized with 2-methylacrylic acid and N,N'-methylene diacrylamide to fabricate dual pH and temperature responsive hydrogels for the controlled release of atorvastatin. The swelling behaviors, pH and temperature responsive atorvastatin release profiles of the hydrogels were investigated. The results indicated that the hydrogel prepared in DMSO exhibited the best swelling rate, which was 51 for 10 min and 252 for 16 h when immersed in medium of buffer solution with pH=8.06. The media with low (pH ≤ 3.84) and high (pH ≥ 10.34) pH values would reduce the swelling rate of hydrogels. The swelling of the hydrogel was increased with increasing temperature from 30 °C to 45 °C. Atorvastatin was loaded in the hydrogel for drug release investigation. The cumulative release rate of atorvastatin was as high as 90.5% in pH=8.06 buffer solution. The solubility of atorvastatin was improved from 0.13 to 1.2mg/mL in the hydrogel.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
authors.forename: Kaiwen
authors.initials: K
authors.lastname: Yang
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
authors.forename: Sicheng
authors.initials: S
authors.lastname: Wan
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Chen
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. Electronic address: wenxiag@wzu.edu.cn.
authors.forename: Wenxia
authors.initials: W
authors.lastname: Gao
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
authors.forename: Jiuxi
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
authors.forename: Miaochang
authors.initials: M
authors.lastname: Liu
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. Electronic address: huayuewu@wzu.edu.cn.
authors.forename: Huayue
authors.initials: H
authors.lastname: Wu
mesh_terms: D000069059:Atorvastatin / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D008689:Methacrylates; D047392:beta-Cyclodextrins; C008384:methacrylic acid; D000069059:Atorvastatin; C031215:betadex
keywords: Drug release; Hydrogel; Swelling kinetics; pH and temperature responsive; β-Cyclodextrin