title: DR-70 as a novel diagnostic biomarker for gastric cancer.
abstract: OBJECTIVE
  To assess the utility of the DR-70 immunoassay in the diagnosis of gastric cancer.
  
  
  METHODS
  A total of 29 patients with histologically proven malignant gastric tumor and 29 healthy blood donors were enrolled in this study. DR-70 immunoassay was performed using an enzyme-linked immunosorbent assay kit to quantify the serum levels of fibrin degradation products.
  
  
  RESULTS
  The DR-70 values in patients with gastric cancer significantly differed from the values in controls (p<0.0001). Receiver operating characteristic curve analysis revealed ≥1.45 µg/mL as the best cut-off value to distinguish between patients with gastric cancer and healthy controls. The area under the receiver operating characteristic curve was 0.871. Using ≥1.45 µg/mL as the cut-off value, the DR-70 immunoassay showed a good clinical performance with a sensitivity of 82.8% and a specificity of 79.3%. The positive predictive value was 80.0%, and the negative predictive value was 82.1%.
  
  
  CONCLUSIONS
  The DR-70 immunoassay reliably differs between gastric cancer and healthy controls, promising to become a useful cancer detection tool in clinical practice.
authors.affiliation: Department of Internal Medicine, Divison of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey. mehmetarhan@gmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Arhan
authors.forename: Hülya
authors.initials: H
authors.lastname: Yılmaz
authors.forename: İbrahim K
authors.initials: İK
authors.lastname: Önal
authors.forename: Murat
authors.initials: M
authors.lastname: Kocabıyık
authors.forename: Harun
authors.initials: H
authors.lastname: Erdal
authors.forename: Mehmet
authors.initials: M
authors.lastname: İbiş
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D055088:Early Detection of Cancer / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012016:Reference Values; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D005338:Fibrin Fibrinogen Degradation Products