title: Genomics-based strategies for the use of natural variation in the improvement of crop metabolism.
abstract: Next-generation genomics holds great potential in the study of plant phenotypic variation. With several crop reference genomes now available, the affordable costs of de novo genome assembly or target resequencing offer the opportunity to mine the enormous amount of genetic diversity hidden in crop wild relatives. Wide introgressions from these wild ancestors species or land races represent a possible strategy to improve cultivated varieties. In this review, we discuss the mechanisms underlying metabolic diversity within plant species and the possible strategies (and barriers) to introgress novel metabolic traits into cultivated varieties. We show how deep genomic surveys uncover various types of structural variants from extended gene pools of major crops and highlight how this variation may be used for the improvement of crop metabolism.
authors.affiliation: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Potsdam, Germany; Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Centro di Ricerca per la Frutticoltura, Via di Fioranello 52, 00134 Rome, Italy. Electronic address: scossa@mpimp-golm.mpg.de.
authors.forename: Federico
authors.initials: F
authors.lastname: Scossa
authors.affiliation: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Potsdam, Germany. Electronic address: brotman@mpimp-golm.mpg.de.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Brotman
authors.affiliation: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Potsdam, Germany. Electronic address: Lima@mpimp-golm.mpg.de.
authors.forename: Francisco
authors.initials: F
authors.lastname: de Abreu E Lima
authors.affiliation: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Potsdam, Germany. Electronic address: willmitzer@mpimp-golm.mpg.de.
authors.forename: Lothar
authors.initials: L
authors.lastname: Willmitzer
authors.affiliation: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Potsdam, Germany. Electronic address: nikoloski@mpimp-golm.mpg.de.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Nikoloski
authors.affiliation: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Potsdam, Germany. Electronic address: tohge@mpimp-golm.mpg.de.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tohge
authors.affiliation: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Potsdam, Germany. Electronic address: fernie@mpimp-golm.mpg.de.
authors.forename: Alisdair R
authors.initials: AR
authors.lastname: Fernie
mesh_terms: D018556:Crops, Agricultural / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D014644:Genetic Variation; D018745:Genome, Plant / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D005838:Genotype; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D010641:Phenotype; D000069600:Plant Breeding / Q000379:methods; D040641:Quantitative Trait Loci / Q000235:genetics; D013045:Species Specificity
keywords: Crop wild relative; Genomics; Hybridization; Metabolomics; Natural variation