title: [The value of narrow-band imaging with magnifying endoscopy in diagnosis of early gastric cancer: a meta-analysis].
abstract: To assess the diagnostic value of narrow-band imaging with magnifying endoscopy (NBI-ME) for early gastric cancer (EGC).
  
  
  
  We searched PubMed, Embase, Web of Science and the Cochrane Library for literature of NBI-ME in diagnosis of EGC, and then performed meta-analysis.
  
  
  
  A total of 12 articles involving 2 278 samples from 2 048 patients were included. The overall sensitivity of NBI-ME for diagnosis of EGC was 0.84 [95% CI: 0.80~0.87], specificity was 0.96 (95% CI: 0.95~0.97),and area under the symmetric receiver operator characteristic curve (AUC) was 0.9592. The AUC value of the NBI-ME plus conventional white light endoscopy (C-WLE) subgroup (0.9706) was higher than that of NBI-ME alone (0.8162). The incremental yield of NBI-ME plus C-WLE over C-WLE was significant (IY = 9.4%, P = 0.011), while NBI-ME alone over C-WLE was not significant (IY = 0.8%, P = 0.498).
  
  
  
  The results show that NBI-ME plus C-WLE is an effective and preferable method for diagnosis of EGC; however, NBI-ME alone is not superior to C-WLE.
authors.affiliation: Department of Gastroenterology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Gastroenterology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Yang
mesh_terms: D055088:Early Detection of Cancer; D005773:Gastroscopy / Q000379:methods*; D006801:Humans; D062048:Narrow Band Imaging; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000175:diagnosis*