title: Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice.
abstract: Accumulating evidence reveals that lipopolysaccharide (LPS) can induce neuroinflammation, ultimately leading to cognitive deficits. Mangiferin, a natural glucoxilxanthone, is known to possess various biological activities. The present study aimed to investigate the effects of mangiferin on LPS-induced cognitive deficits and explore the underlying mechanisms. Brain injury was induced in mice via intraperitoneal LPS injection (1mg/kg) for five consecutive days. Mangiferin was orally pretreatmented (50mg/kg) for seven days and then treatmented (50mg/kg) for five days after LPS injection. The Morris water maze was used to detect changes in cognitive function. Immunohistochemical and immunoblotting were respectively performed to measure the expression of interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) in the hippocampus. The results showed that mangiferin can ameliorate cognitive deficits. Moreover, mangiferin decreased LPS-induced IL-6 production and increase HO-1 in the hippocampus. Taken together, these results suggest that mangiferin attenuates LPS-induced cognitive deficits, which may be potentially linked to modulating HO-1 in the hippocampus.
authors.affiliation: Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China; Department of Cell biology and Neurobiology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Physiology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Chengjie
authors.initials: C
authors.lastname: Song
authors.affiliation: Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Cell biology and Neurobiology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cell biology and Neurobiology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.affiliation: Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China; Department of Physiology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Xiangru
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of endocrinology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, 221002, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Liang
authors.affiliation: Department of Medical Information, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Kai
authors.initials: K
authors.lastname: Ma
authors.affiliation: Department of Geriatrics, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, 221002, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: School of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Xunbao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Shao
authors.affiliation: Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Du
authors.affiliation: Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China; Department of Genetics and Research Center for Neurobiology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China. Electronic address: biosongyuanjian@126.com.
authors.forename: Yuanjian
authors.initials: Y
authors.lastname: Song
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D051547:Heme Oxygenase-1 / Q000096:biosynthesis / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D015850:Interleukin-6 / Q000096:biosynthesis / Q000235:genetics; D007858:Learning / Q000187:drug effects; D008070:Lipopolysaccharides; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051379:Mice; D018697:Nootropic Agents / Q000627:therapeutic use*; D044004:Xanthones / Q000627:therapeutic use*
chemical_list: D015850:Interleukin-6; D008070:Lipopolysaccharides; D018697:Nootropic Agents; D044004:Xanthones; C577686:interleukin-6, mouse; C013592:mangiferin; D051547:Heme Oxygenase-1
keywords: Cognitive; Heme oxygenase-1; Lipopolysaccharide; Mangiferin