title: A natural reassortant and mutant serotype 3 reovirus from mink in China.
abstract: Mammalian orthoreoviruses (MRVs) are widespread and infect virtually all mammals. We report here the first case of a natural mutant and reassortant serotype 3 reovirus from mink in China, known as MRV3 SD-14. Whole-genome sequence analysis showed that the MRV3 SD-14 may have resulted from a reassortment involving MRVs that infected swine, humans and mink. Interestingly, the S1 segment, which encodes the viral attachment protein σ1, which influences viral virulence and cell tropism in the host, had a stop codon mutation at amino acid 246. Surveillance of the virulence and evolution of MRVs in humans and other animals deserves more attention.
authors.affiliation: Laboratory of Epidemiology, Institute of Military Veterinary, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 666 Liuying West Road, Changchun, 130122, Jilin, China.
authors.forename: Yong-Wu
authors.initials: YW
authors.lastname: Zhang
authors.affiliation: Laboratory of Epidemiology, Institute of Military Veterinary, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 666 Liuying West Road, Changchun, 130122, Jilin, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Laboratory of Epidemiology, Institute of Military Veterinary, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 666 Liuying West Road, Changchun, 130122, Jilin, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Lian
authors.affiliation: Laboratory of Epidemiology, Institute of Military Veterinary, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 666 Liuying West Road, Changchun, 130122, Jilin, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Laboratory of Epidemiology, Institute of Military Veterinary, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 666 Liuying West Road, Changchun, 130122, Jilin, China. zhangshoufeng@hotmail.com.
authors.forename: Shou-Feng
authors.initials: SF
authors.lastname: Zhang
authors.affiliation: Laboratory of Epidemiology, Institute of Military Veterinary, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 666 Liuying West Road, Changchun, 130122, Jilin, China. ronglianghu@hotmail.com.
authors.forename: Rong-Liang
authors.initials: RL
authors.lastname: Hu
mesh_terms: D000818:Animals; D002681:China; D018389:Codon, Nonsense; D016679:Genome, Viral; D006801:Humans; D012089:Mammalian orthoreovirus 3 / Q000145:classification* / Q000235:genetics*; D008907:Mink / Q000821:virology*; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics*; D016865:Reassortant Viruses / Q000145:classification* / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013552:Swine; D014759:Viral Envelope Proteins / Q000235:genetics
chemical_list: D018389:Codon, Nonsense; D012367:RNA, Viral; D014759:Viral Envelope Proteins