title: [Research Advances in NLRP3 Inflammasome-related Regulatory Mechanisms].
abstract: Inflammasome is one of the pattern recognition receptors whose activation directly relates to the maturity and secretion of proinflammatory cytokines interleukin (IL)-1Β and IL-18. Thus, it plays an important role in the humoral immunity. A growing number of studies have found that inflammasome has a close relationship with the pathogenesis of various diseases including atherosclerosis,diabetes, and gout. However,the activation of the inflammasome and its specific regulatory mechanisms remain not clear. This article reviews the possible regulatory mechanisms of the inflammasome NLRP3 in terms of oxidative stress, endoplasmic reticulum stress,and autophagy reaction.
authors.affiliation: Graduate School,2Department of Cardiovascular Diseases,the First Teaching Hospital,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China.
authors.forename: Cheng-yi
authors.initials: CY
authors.lastname: Wang
authors.forename: Xiao-chen
authors.initials: XC
authors.lastname: Guo
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002352:Carrier Proteins; D006801:Humans; D058847:Inflammasomes; D007249:Inflammation; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human