title: Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis.
abstract: Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multiorgan failure and death. We report a case of HLH in a patient with human immunodeficiency virus, disseminated histoplasmosis, Mycobacterium avium complex, and Escherichia coli bacteremia. We discuss management of acutely ill patients with HLH and treatment of the underlying infection versus initiation of HLH-specific chemotherapy.
authors.affiliation: University of Washington School of Medicine.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Castelli
authors.affiliation: Department of Medicine.
authors.forename: David G
authors.initials: DG
authors.lastname: Rosenthal
authors.affiliation: Division of Allergy and Infectious Diseases, Department of Medicine , University of Washington ; Global Oncology, Vaccine and Infectious Disease Division , Fred Hutchinson Cancer Research Center , Seattle, Washington.
authors.forename: Rachel
authors.initials: R
authors.lastname: Bender Ignacio
authors.affiliation: Division of Allergy and Infectious Diseases, Department of Medicine , University of Washington.
authors.forename: Helen Y
authors.initials: HY
authors.lastname: Chu
keywords: HIV; HLH; histoplasmosis