title: Quantification of hepatic functional capacity: a call for standardization.
abstract: Reliable assessments of liver function are becoming increasingly important as more patients with surgically amenable liver disease are considered for treatment. Static markers of liver function are not sufficient to provide accurate assessments of hepatic function in order to risk stratify patients undergoing hepatic resection. Metabolic tests are dynamic indicators of liver function, but can be unreliable under certain conditions and thus difficult to make comparisons. Clearance tests avoid some of the pitfalls encountered during metabolic testing, but depend on hepatic blood flow and say little about hepatocyte function. Testing that combines imaging with measures of hepatocyte uptake may offer the most utility when planning surgical resections.
authors.affiliation: a Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery , David Geffen School of Medicine at University of California, Los Angeles , 757 Westwood Plaza, Los Angeles , CA 90095 , USA.
authors.forename: Bernard J
authors.initials: BJ
authors.lastname: DuBray
authors.affiliation: a Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery , David Geffen School of Medicine at University of California, Los Angeles , 757 Westwood Plaza, Los Angeles , CA 90095 , USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Zarrinpar
mesh_terms: D001944:Breath Tests; D004396:Coloring Agents / Q000378:metabolism; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D008099:Liver / Q000503:physiopathology*; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D018570:Risk Assessment; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green
keywords: allograft assessment; donor quality; hepatic functional capacity; hepatic reserve; volumetrics