title: The potential diagnostic power of circulating tumor cell analysis for non-small-cell lung cancer.
abstract: In non-small-cell lung cancer (NSCLC), genotyping tumor biopsies for targetable somatic alterations has become routine practice. However, serial biopsies have limitations: they may be technically difficult or impossible and could incur serious risks to patients. Circulating tumor cells (CTCs) offer an alternative source for tumor analysis that is easily accessible and presents the potential to identify predictive biomarkers to tailor therapies on a personalized basis. Examined here is our current knowledge of CTC detection and characterization in NSCLC and their potential role in EGFR-mutant, ALK-rearranged and ROS1-rearranged patients. This is followed by discussion of the ongoing issues such as the question of CTC partnership as diagnostic tools in NSCLC.
authors.affiliation: a INSERM, U981 "Identification of Molecular Predictors and new Targets for Cancer Treatment" , F-94805 , VILLEJUIF , France.|b Gustave Roussy, Université Paris-Saclay , "Circulating Tumor Cells" Translational Platform, CNRS UMS3655 - INSERM US23 AMMICA, F-94805 , VILLEJUIF , France.
authors.forename: Kirsty
authors.initials: K
authors.lastname: Ross
authors.affiliation: a INSERM, U981 "Identification of Molecular Predictors and new Targets for Cancer Treatment" , F-94805 , VILLEJUIF , France.|b Gustave Roussy, Université Paris-Saclay , "Circulating Tumor Cells" Translational Platform, CNRS UMS3655 - INSERM US23 AMMICA, F-94805 , VILLEJUIF , France.
authors.forename: Emma
authors.initials: E
authors.lastname: Pailler
authors.affiliation: a INSERM, U981 "Identification of Molecular Predictors and new Targets for Cancer Treatment" , F-94805 , VILLEJUIF , France.|b Gustave Roussy, Université Paris-Saclay , "Circulating Tumor Cells" Translational Platform, CNRS UMS3655 - INSERM US23 AMMICA, F-94805 , VILLEJUIF , France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Faugeroux
authors.affiliation: a INSERM, U981 "Identification of Molecular Predictors and new Targets for Cancer Treatment" , F-94805 , VILLEJUIF , France.
authors.forename: Melissa
authors.initials: M
authors.lastname: Taylor
authors.affiliation: a INSERM, U981 "Identification of Molecular Predictors and new Targets for Cancer Treatment" , F-94805 , VILLEJUIF , France.|b Gustave Roussy, Université Paris-Saclay , "Circulating Tumor Cells" Translational Platform, CNRS UMS3655 - INSERM US23 AMMICA, F-94805 , VILLEJUIF , France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Oulhen
authors.affiliation: c Department of Biopathology , Gustave Roussy , Villejuif , France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Auger
authors.affiliation: d Department of Medicine , Gustave Roussy, F-94805 , Villejuif , France.
authors.forename: David
authors.initials: D
authors.lastname: Planchard
authors.affiliation: a INSERM, U981 "Identification of Molecular Predictors and new Targets for Cancer Treatment" , F-94805 , VILLEJUIF , France.|d Department of Medicine , Gustave Roussy, F-94805 , Villejuif , France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Soria
authors.affiliation: a INSERM, U981 "Identification of Molecular Predictors and new Targets for Cancer Treatment" , F-94805 , VILLEJUIF , France.|b Gustave Roussy, Université Paris-Saclay , "Circulating Tumor Cells" Translational Platform, CNRS UMS3655 - INSERM US23 AMMICA, F-94805 , VILLEJUIF , France.
authors.forename: Colin R
authors.initials: CR
authors.lastname: Lindsay
authors.affiliation: d Department of Medicine , Gustave Roussy, F-94805 , Villejuif , France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Besse
authors.affiliation: a INSERM, U981 "Identification of Molecular Predictors and new Targets for Cancer Treatment" , F-94805 , VILLEJUIF , France.|b Gustave Roussy, Université Paris-Saclay , "Circulating Tumor Cells" Translational Platform, CNRS UMS3655 - INSERM US23 AMMICA, F-94805 , VILLEJUIF , France.|c Department of Biopathology , Gustave Roussy , Villejuif , France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Vielh
authors.affiliation: a INSERM, U981 "Identification of Molecular Predictors and new Targets for Cancer Treatment" , F-94805 , VILLEJUIF , France.|b Gustave Roussy, Université Paris-Saclay , "Circulating Tumor Cells" Translational Platform, CNRS UMS3655 - INSERM US23 AMMICA, F-94805 , VILLEJUIF , France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Farace
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism; D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics*; D004273:DNA, Neoplasm / Q000097:blood; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods; D023281:Genomics / Q000379:methods; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D025202:Molecular Diagnostic Techniques; D009360:Neoplastic Cells, Circulating / Q000378:metabolism* / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D011379:Prognosis
chemical_list: D000954:Antigens, Surface; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
keywords: ALK rearrangement; Circulating tumor cells; EGFR mutation; diagnostic biomarkers; non-small-cell lung carcinoma