title: Fabrication and characterization of cefazolin-loaded nanofibrous mats for the recovery of post-surgical wound.
abstract: The aim of the present study was to evaluate the wound healing performance of cefazolin-loaded gelatin nanofiber mats in post-operative wound. The obtained nanofibers were smooth, non-beaded and having diameter ranging from 620-680 nm. Nanofiber mats that are prepared exhibit high drug entrapment, excellent oxygen permeability and sustained drug release behavior. Further, medicated nanofiber mats showed an accelerated wound healing as compared to plain cefazolin. Macroscopical and histological evaluations demonstrated that cefazolin-loaded gelatin nanofiber showed increased epithelialization rate and collagen deposition. The results indicated that therapeutic strategies offer new prospects in the management of post-operative wound repair.
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.|b Punjab Technical University , Jalandhar , India.
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Taqadus
authors.initials: T
authors.lastname: Hussain
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Chauhan
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar Goyal
mesh_terms: D002437:Cefazolin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D057139:Nanofibers / Q000737:chemistry*; D000072836:Surgical Wound / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000188:drug therapy*
chemical_list: D003692:Delayed-Action Preparations; D002437:Cefazolin
keywords: Cefazolin; controlled drug release; gelatin nanofibers; post-operative wound healing