title: The preventive and therapeutic potential of natural polyphenols on influenza.
abstract: Influenza virus belongs to orthomyxoviridae family. This virus is a major public health problems, with high rates of morbidity and mortality. Despite a wide range of pharmacotherapeutic choices inhibiting specific sequences of pathological process of influenza, developing more effective therapeutic options is an immediate challenge. In this paper, a comprehensively review of natural polyphenolic products used worldwide for the management of influenza infection is presented. Cellular and molecular mechanisms of the natural polyphenols on influenza infection including suppressing virus replication cycle, viral hemagglutination, viral adhesion and penetration into the host cells, also intracellular transductional signaling pathways have been discussed in detail. Based on cellular, animal, and human evidence obtained from several studies, the current paper demonstrates that natural polyphenolic compounds possess potential effects on both prevention and treatment of influenza, which can be used as adjuvant therapy with conventional chemical drugs for the management of influenza and its complications.
authors.affiliation: a Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Roodabeh
authors.initials: R
authors.lastname: Bahramsoltani
authors.affiliation: b Young Researchers and Elite Club , Karaj Branch, Islamic Azad University , Karaj , Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Sodagari
authors.affiliation: c Pharmaceutical Sciences Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.|d Medical Biology Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.
authors.forename: Mohammad Hosein
authors.initials: MH
authors.lastname: Farzaei
authors.affiliation: e Medicinal Plants Research Center , Institute of Medicinal Plants, ACECR , Karaj , Iran.|f International Campus, ICTUMS, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Amir Hossein
authors.initials: AH
authors.lastname: Abdolghaffari
authors.affiliation: g Faculty of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Maziar
authors.initials: M
authors.lastname: Gooshe
authors.affiliation: h Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.|i Molecular Immunology Research Center and Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.|j Universal Scientific Education and Research Network (USERN) , Tehran , Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006387:Hemagglutination, Viral / Q000187:drug effects; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy* / Q000517:prevention & control / Q000821:virology; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053586:Virus Internalization / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001688:Biological Products; D010936:Plant Extracts; D059808:Polyphenols
keywords: Influenza; alternative medicine; antiviral effect; natural medicine; polyphenols; respiratory infection; viral disease