title: Usefulness of ultrasonographic estimation of preperitoneal and subcutaneous fat thickness in the diagnosis of nonalcoholic fatty liver disease in diabetic patients.
abstract: OBJECTIVE
  Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) have been regarded as the hepatic manifestation of metabolic syndrome. Abdominal wall fat index (AFI), defined as the ratio of preperitoneal and subcutaneous fat thickness in the abdomen estimated by ultrasonography (US), has been shown to be useful in screening for disorders related to metabolic syndrome. We investigated the relation between AFI and NAFLD/NASH in diabetic patients.
  
  
  METHODS
  The degree of fat accumulation in the liver and the thickness of preperitoneal and subcutaneous fat were determined by US in 340 diabetic patients. An NAFLD fibrosis score (NAFLD-FS) was used to assess the advancement of hepatic fibrosis in NAFLD patients.
  
  
  RESULTS
  Of all 340 subjects, 209 (61 %) were diagnosed with NAFLD by US. AFI of NAFLD subjects was significantly higher than that of non-NAFLD subjects. Of the 209 subjects with NAFLD, 31 (15 %) were shown to have advanced NASH fibrosis according to NAFLD-FS. Multivariate analysis identified AFI as a significant predictor of advanced fibrosis.
  
  
  CONCLUSIONS
  AFI easily obtained by US was significantly related to the presence of NAFLD and/or advanced hepatic fibrosis in diabetic patients.
authors.affiliation: Department of Gastroenterology, Ikeda Municipal Hospital, 3-1-18 Jonan, Ikeda, Osaka, 563-8510, Japan. fukuda-imhp@umin.ac.jp.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Fukuda
authors.affiliation: Department of Ultrasonography, Ikeda Municipal Hospital, Ikeda, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Seki
authors.affiliation: Department of Ultrasonography, Ikeda Municipal Hospital, Ikeda, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ichihi
authors.affiliation: Department of Endocrinology and Metabolism, Ikeda Municipal Hospital, Ikeda, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Okada
authors.affiliation: Department of Endocrinology and Metabolism, Ikeda Municipal Hospital, Ikeda, Japan.
authors.forename: Ayumu
authors.initials: A
authors.lastname: Hirata
authors.affiliation: Department of Gastroenterology, Ikeda Municipal Hospital, 3-1-18 Jonan, Ikeda, Osaka, 563-8510, Japan.
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Kogita
authors.affiliation: Department of Gastroenterology, Ikeda Municipal Hospital, 3-1-18 Jonan, Ikeda, Osaka, 563-8510, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sawai
authors.affiliation: Department of Gastroenterology, Ikeda Municipal Hospital, 3-1-18 Jonan, Ikeda, Osaka, 563-8510, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Igura
authors.affiliation: Department of Endocrinology and Metabolism, Ikeda Municipal Hospital, Ikeda, Japan.
authors.forename: Mamiko
authors.initials: M
authors.lastname: Tsugawa
authors.affiliation: Department of Gastroenterology, Ikeda Municipal Hospital, 3-1-18 Jonan, Ikeda, Osaka, 563-8510, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Imai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D048909:Diabetes Complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000000981:diagnostic imaging*; D010537:Peritoneum / Q000000981:diagnostic imaging* / Q000473:pathology*; D012189:Retrospective Studies; D050151:Subcutaneous Fat / Q000000981:diagnostic imaging* / Q000473:pathology*; D014463:Ultrasonography; D055815:Young Adult
keywords: Diabetes mellitus; NAFLD; NASH; Ultrasonography; Visceral fat