title: A perspective on sympathetic renal denervation in chronic congestive heart failure.
abstract: Medical therapy has indisputably been the mainstay of management for chronic congestive heart failure. However, a significant percentage of patients continue to experience worsening heart failure (HF) symptoms despite treatment with multiple therapeutic agents. Recently, catheter-based interventional strategies that interrupt the renal sympathetic nervous system have shown promising results in providing better symptom control in patients with HF. In this article, we will review the pathophysiology of HF for better understanding of the interplay between the cardiovascular system and the kidney. Subsequently, we will briefly discuss pivotal renal denervation (RDN) therapy trials in patients with resistant hypertension and then present the available evidence on the role of RDN in HF therapy.
authors.affiliation: Center for Advanced Cardiac Therapeutics, St. Francis Hospital - The Heart Center®, 100 Port Washington Blvd., Roslyn, NY, 11576-1348, USA. raef.madanieh@gmail.com.
authors.forename: Raef
authors.initials: R
authors.lastname: Madanieh
authors.affiliation: Presence Saint Joseph Hospital, Chicago, IL, USA.
authors.forename: Mohammed
authors.initials: M
authors.lastname: El-Hunjul
authors.affiliation: Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, Elmhurst, NY, USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Alkhawam
authors.affiliation: Mount Sinai Hospital Center, Icahn School of Medicine, New York, NY, USA.
authors.forename: Constantine E
authors.initials: CE
authors.lastname: Kosmas
authors.affiliation: Center for Advanced Cardiac Therapeutics, St. Francis Hospital - The Heart Center®, 100 Port Washington Blvd., Roslyn, NY, 11576-1348, USA.
authors.forename: Abed
authors.initials: A
authors.lastname: Madanieh
authors.affiliation: Center for Advanced Cardiac Therapeutics, St. Francis Hospital - The Heart Center®, 100 Port Washington Blvd., Roslyn, NY, 11576-1348, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Vittorio
mesh_terms: D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007668:Kidney / Q000294:innervation / Q000503:physiopathology; D013562:Sympathectomy / Q000379:methods*; D013564:Sympathetic Nervous System / Q000601:surgery
keywords: Heart failure; Renal denervation; Sympathetic nervous system