title: Dietary polyphenols increase fecal mucin and immunoglobulin A and ameliorate the disturbance in gut microbiota caused by a high fat diet.
abstract: The effects of dietary polyphenols on human health have mainly been discussed in the context of preventing degenerative diseases, particularly cardiovascular diseases and cancer. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanism of action of polyphenols extends beyond the modulation of oxidative stress, as they are poorly absorbed from the digestive tract. The purpose of this study was to clarify the effects of polyphenols on the colonic environment, intestinal barrier function, and gut microbiota. We demonstrated that dietary polyphenols derived from aronia, haskap, and bilberry, markedly elevated the amount of fecal mucin and immunoglobulin A (IgA) as an intestinal barrier function and ameliorated the disturbance in gut microbiota caused by a high fat diet in rats. These results suggest that dietary polyphenols play a significant role in the prevention of degenerative diseases through improvement of the colonic environment without any absorption from the digestive tract.
authors.affiliation: Primary Cell Division, Cosmo Bio Co., Ltd., YS BLDG., kita12-Chome, Nishi-Machi, Nishi-ku, Sapporo 063-0061, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Taira
authors.affiliation: Primary Cell Division, Cosmo Bio Co., Ltd., YS BLDG., kita12-Chome, Nishi-Machi, Nishi-ku, Sapporo 063-0061, Japan.
authors.forename: Sayori
authors.initials: S
authors.lastname: Yamaguchi
authors.affiliation: Division of Agrobiology, Graduate School of Agriculture, Hokkaido University, Kita9 Nishi-9, Kita-ku, Sapporo Hokkaido 060-8589, Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Faculty of Human Life Sciences, Fuji Women's University, Hanakawa, Ishikari 061-3204, Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Okazaki
authors.affiliation: Primary Cell Division, Cosmo Bio Co., Ltd., YS BLDG., kita12-Chome, Nishi-Machi, Nishi-ku, Sapporo 063-0061, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yamaguchi
authors.affiliation: Food Development Laboratories, Functional Food Division, Nippon Shinyaku Co., Ltd., 14 Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.
authors.forename: Hirohide
authors.initials: H
authors.lastname: Sakaguchi
authors.affiliation: Faculty of Human Life Sciences, Fuji Women's University, Hanakawa, Ishikari 061-3204, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Chiji
keywords: gut microbiota; immunoglobulin A; mucin; polyphenol