title: A new triterpenoid saponin from Gleditsia sinensis and its antiproliferative activity.
abstract: Chemical investigation of the anomalous fruits of Gleditsia sinensis led to the isolation and identification of a new triterpenoid saponin, 3-O-β-D-xylopyranosyl-(1 → 2)-α-L-arabinopyranosyl-(1 → 6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyrano--syl-(1 → 4)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 3)-β-D-glucopyranosyl ester (1), along with other nine known compounds (2-10). All the isolates from this species were reported for the first time. The structure of Compound 1 was determined by a detailed analysis using various analytical techniques, including 1D and 2D NMR. In vitro antiproliferative activities of Compound 1 on MCF-7 and Hep-G2 tumor cell lines were evaluated. IC50 values against the two cell lines were 9.5 and 11.6 μM, respectively.
authors.affiliation: a Institute of Agro-Food Science and Technology , Shandong Academy of Agricultural Sciences , Jinan , P.R. China.|b Key Laboratory of Agro-Products Processing Technology of Shandong Province , Jinan , P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: c Shandong Chengchuang Pharmaceutical R＆D Co., Ltd , Jinan , P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Sun
authors.affiliation: a Institute of Agro-Food Science and Technology , Shandong Academy of Agricultural Sciences , Jinan , P.R. China.|b Key Laboratory of Agro-Products Processing Technology of Shandong Province , Jinan , P.R. China.
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Wang
authors.affiliation: d Department of Genetics , Weifang Medical University , Weifang , P.R. China.
authors.forename: Jin-Bao
authors.initials: JB
authors.lastname: Zhang
authors.affiliation: a Institute of Agro-Food Science and Technology , Shandong Academy of Agricultural Sciences , Jinan , P.R. China.|b Key Laboratory of Agro-Products Processing Technology of Shandong Province , Jinan , P.R. China.
authors.forename: An-Wei
authors.initials: AW
authors.lastname: Cheng
authors.affiliation: a Institute of Agro-Food Science and Technology , Shandong Academy of Agricultural Sciences , Jinan , P.R. China.|b Key Laboratory of Agro-Products Processing Technology of Shandong Province , Jinan , P.R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Guo
authors.affiliation: a Institute of Agro-Food Science and Technology , Shandong Academy of Agricultural Sciences , Jinan , P.R. China.|b Key Laboratory of Agro-Products Processing Technology of Shandong Province , Jinan , P.R. China.
authors.forename: Jin-Yue
authors.initials: JY
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D031501:Gleditsia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C000618912:3-O-beta-D-xylopyranosyl-(1-2)-alpha-L-arabinopyranosyl-(1-6)-beta-D-glucopyranosyl oleanolic acid 28-O-beta-D-xylopyranosyl-(1-4)-alpha-L-rhamnopyranosyl-(1-4)-beta-D-xylopyranosyl-(1-4)-alpha-L-rhamnopyranosyl-(1-3)-beta-D-glucopyranosyl ester; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes
keywords: Gleditsia sinensis; antiproliferative; triterpenoid saponin