title: Meta-analysis of the rs2075650 polymorphism and risk of Alzheimer disease.
abstract: BACKGROUND
  Several researchers have suggested that the rs2075650 polymorphism is significantly associated with an increased risk of developing Alzheimer disease (AD) in European. However, some others found inconsistent results in Asian (Chinese and Korean). We addressed the controversy through performing a meta-analysis of the relationship between rs2075650 in TOMM40 (translocase of outer mitochondrial membrane 40 homologue) and Alzheimer disease.
  
  
  METHODS
  We selected eight case-control studies involving 4290 cases of Alzheimer disease and 5556 healthy individuals. The association between the TOMM40 rs2075650 polymorphism and Alzheimer disease was examined by overall odds ratio (OR) with a 95 % confidence interval (CI). We used different genetic model analysis, sensitivity analysis, and assessments of bias in our meta-analysis.
  
  
  RESULTS
  The pooled analysis showed the inconsistent results that TOMM40 rs2075650 polymorphism was associated with Alzheimer disease in European and Korean population in all genetic models, but there was no significant association between the TOMM40 rs2075650 polymorphism and Alzheimer disease risk in Chinese population.
  
  
  CONCLUSIONS
  We conclude that rs2075650 in TOMM40 gene may increase the risk of Alzheimer disease.
authors.affiliation: Department of Geriatrics Neurology, The Second Affiliated Hospital, Medical School of Xi'an Jiao Tong University, 157 Xi'wu Road, Xi'an, 710004, Shanxi, People's Republic of China.
authors.forename: Ya
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Geriatrics Neurology, The Second Affiliated Hospital, Medical School of Xi'an Jiao Tong University, 157 Xi'wu Road, Xi'an, 710004, Shanxi, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Geriatrics Neurology, The Second Affiliated Hospital, Medical School of Xi'an Jiao Tong University, 157 Xi'wu Road, Xi'an, 710004, Shanxi, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Inner Mongolia Medical University, Huhehot, 010030, Inner Mongolia, People's Republic of China.|Department of Orthopedics and Traumatology, The 2nd Affiliated Hospital of Inner Mongolia University, Huhehot, 010030, Inner Mongolia, People's Republic of China.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Li
authors.affiliation: Inner Mongolia Medical University, Huhehot, 010030, Inner Mongolia, People's Republic of China.|Department of Orthopedics and Traumatology, The 2nd Affiliated Hospital of Inner Mongolia University, Huhehot, 010030, Inner Mongolia, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, People's Republic of China.|National Engineering Research Center for Miniaturized Detection System, Xi'an, 710069, Shanxi, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, People's Republic of China.|National Engineering Research Center for Miniaturized Detection System, Xi'an, 710069, Shanxi, People's Republic of China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Geriatrics Neurology, The Second Affiliated Hospital, Medical School of Xi'an Jiao Tong University, 157 Xi'wu Road, Xi'an, 710004, Shanxi, People's Republic of China. chensongshengCS@163.com.
authors.forename: Songsheng
authors.identifier: http://orcid.org/0000-0002-8036-8985
authors.initials: S
authors.lastname: Chen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics*; D008875:Middle Aged; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: D026901:Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; C400783:TOMM40 protein, human
keywords: Alzheimer disease; Meta-analysis; Polymorphism; rs2075650