title: Severe and Progressive Fetal Ventriculomegaly Leading to the Diagnosis of Periventricular Nodular Heterotopias with Good Outcome.
abstract: Severe fetal ventriculomegaly is generally associated with poor prognosis in terms of survival and neurodevelopment outcome. As such, many parents opt to terminate the pregnancy independently of a known etiology. We report here the case of a female fetus with severe progressive ventriculomegaly due to the unexpected presence of bilateral nodular periventricular heterotopias visualized on MRI of a fetal brain. Reaching a structural diagnosis was perceived as a relief for the parents and the pregnancy was continued. Neurodevelopment assessment at 3 years of age is normal with no epilepsy.
authors.affiliation: Pediatric Neurology, Pediatric Subspecialties Service, Geneva Children's Hospital, Switzerland.
authors.forename: Joel
authors.initials: J
authors.lastname: Fluss
authors.affiliation: Department of Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Pellegrinelli
authors.affiliation: Genetic Medicine, University Hospitals of Geneva, Switzerland.
authors.forename: Siv
authors.initials: S
authors.lastname: Fokstuen
authors.affiliation: Pediatric Neurology, Hôpital d'Enfants Armand-Trousseau, Paris, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Moutard
authors.affiliation: Department of Pediatric Radiology, Hôpital d'Enfants Armand-Trousseau, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Garel
authors.affiliation: Service de Neurologie pédiatrique, Hôpital Necker Enfants Malades, Paris, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Bahi-Buisson
authors.affiliation: Department of Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Bilieux
authors.affiliation: Pediatric Radiology Unit, University of Geneva Children's Hospital, Switzerland.
authors.forename: Sylviane
authors.initials: S
authors.lastname: Hanquinet
mesh_terms: D002552:Cerebral Ventricles / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005315:Fetal Diseases / Q000473:pathology*; D005333:Fetus; D006801:Humans; D008279:Magnetic Resonance Imaging; D054091:Periventricular Nodular Heterotopia / Q000175:diagnosis* / Q000473:pathology*; D011247:Pregnancy; D011296:Prenatal Diagnosis