title: Use of Candida antigen injections for the treatment of verruca vulgaris: A two-year mayo clinic experience.
abstract: Common warts (verruca vulgaris) are one of the most common problems encountered in dermatology and may present a difficult treatment dilemma, as no particular therapy has demonstrated complete efficacy. Intralesional injection of purified Candida antigen has produced impressive treatment results in small prospective and retrospective studies and is thought to produce its effect through stimulation of a cell-mediated immune response. We report a retrospective study of adult and pediatric patients treated with Candida antigen therapy in clinical practice. Of the 100 patients treated, 80% responded to therapy: 39% demonstrated a complete response and 41% demonstrated a partial response. In addition, 6 out of 7 immunocompromised patients who were treated demonstrated a partial or complete response. Injections were generally well-tolerated and adverse events were minimal and short-lived. Our data indicate that intralesional Candida antigen therapy for cutaneous warts is an efficacious option in a clinical practice setting. The treatment may also be effective in immunosuppressed patients with cutaneous warts. Our results add to the literature one of the largest retrospective series reported to date and treatment outcomes are similar to previously reported studies evaluating this therapeutic modality.
authors.affiliation: a Department of Dermatology , University of Cincinnati , Cincinnati , OH , USA .
authors.forename: Ali
authors.initials: A
authors.lastname: Alikhan
authors.affiliation: b Department of Dermatology , Baylor University Medical Center , Dallas , TX , USA , and.
authors.forename: John R
authors.initials: JR
authors.lastname: Griffin
authors.affiliation: c Department of Dermatology , Mayo Clinic , Rochester , MN , USA.
authors.forename: Catherine C
authors.initials: CC
authors.lastname: Newman
mesh_terms: D000328:Adult; D000946:Antigens, Fungal / Q000008:administration & dosage*; D002175:Candida; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007167:Immunotherapy / Q000379:methods; D015552:Injections, Intralesional; D012189:Retrospective Studies; D016896:Treatment Outcome; D014860:Warts / Q000628:therapy*
chemical_list: D000946:Antigens, Fungal
keywords: Immunotherapy; human papillomavirus; intralesional; warts