title: Differences in sequential posttreatment salivary IL-6 levels between patients with and patients without locoregional recurrences of oral squamous cell carcinoma: Part III of a cohort study.
abstract: OBJECTIVE
  Sequential postoperative salivary interleukin-6 (IL-6) concentrations were examined in patients with oral squamous cell carcinoma (OSCC) who had early or late locoregional recurrences or those who did not.
  
  
  METHODS
  Twenty-seven consecutive patients with OSCC were originally included in the study. All patients underwent radical surgery. Four saliva samples were collected before (periods I and II) and after (periods III and IV) surgery, and IL-6 concentrations were measured.
  
  
  RESULTS
  Although postoperative (period III: at the time of discharge) salivary IL-6 level was significantly higher in patients with early locoregional recurrence (P = .02) than in those without, no such relationships were observed for preoperative IL-6 concentrations (periods I and II). Postoperative (period IV: 24 months after surgery) IL-6 level was significantly higher in patients with late locoregional recurrence (P = .03) than in those without, but no such relationships were observed for IL-6 concentrations in periods I, II, and III.
  
  
  CONCLUSIONS
  Sequential postoperative salivary IL-6 concentration may be a useful marker for diagnosis of early and late locoregional recurrence in OSCC.
authors.affiliation: Lecturer, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan. Electronic address: jun-s@den.hokudai.ac.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Sato
authors.affiliation: Clinical Fellow, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Ohuchi
authors.affiliation: Clinical Fellow, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Wada
authors.affiliation: Assistant Professor, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Noritaka
authors.initials: N
authors.lastname: Ohga
authors.affiliation: Assistant Professor, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Asaka
authors.affiliation: Assistant Professor, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Yoshikawa
authors.affiliation: Assistant Professor, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Miyakoshi
authors.affiliation: Assistant Professor, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Hata
authors.affiliation: Lecturer, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Satoh
authors.affiliation: Professor and Chairman, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kitagawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D012463:Saliva / Q000737:chemistry*
chemical_list: D015850:Interleukin-6