title: Immunosuppression and Abdominal Wall Defects: Use of Autologous Dermis.
abstract: OBJECTIVE
  The purpose of the present study was to analyze the use of autologous dermis compared to non-biological meshes in repair of abdominal wall defects in patients with redundant skin and immunosuppression.
  
  
  METHODS
  Eighteen patients with abdominal wall defects, immunosuppression and with redundant skin were divided into two groups: Group A consisted of 11 patients treated with autologous dermis. In these patients, autologous dermis was isolated from the amount of skin resected from the inferior abdominal region that was used as a reinforcement of fascial margins above the defect. Group B consisted of seven patients treated with non-biological meshes We evaluated the infection rate of these groups.
  
  
  RESULTS
  The infection rate was significantly lower in group A patients.
  
  
  CONCLUSIONS
  The transplantation of autologous dermis as a reinforcement for the reconstruction of abdominal wall defects is reasonable for highly selected patients. The use of the dermis was proven useful and we found a lower rate of infection and recurrence.
authors.affiliation: Plastic Surgery Division, General and Specialist Surgery Department, S. Maria alle Scotte Polyclinic, University of Siena, Siena, Italy robertocuomo@outlook.com.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cuomo
authors.affiliation: Plastic Surgery Division, General and Specialist Surgery Department, S. Maria alle Scotte Polyclinic, University of Siena, Siena, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nisi
authors.affiliation: Plastic Surgery Division, General and Specialist Surgery Department, S. Maria alle Scotte Polyclinic, University of Siena, Siena, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Grimaldi
authors.affiliation: Plastic Surgery Division, General and Specialist Surgery Department, S. Maria alle Scotte Polyclinic, University of Siena, Siena, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Brandi
authors.affiliation: Plastic Surgery Division, General and Specialist Surgery Department, S. Maria alle Scotte Polyclinic, University of Siena, Siena, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sisti
authors.affiliation: Plastic Surgery Division, General and Specialist Surgery Department, S. Maria alle Scotte Polyclinic, University of Siena, Siena, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: D'Aniello
mesh_terms: D000009:Abdominal Muscles / Q000473:pathology / Q000637:transplantation*; D034861:Abdominal Wall / Q000503:physiopathology* / Q000601:surgery; D020405:Dermis / Q000637:transplantation*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D013526:Surgical Mesh; D014182:Transplantation, Autologous; D014945:Wound Healing
keywords: Abdominal wall defects; autologous dermal graft; hernias