title: [Synthesis and antioxidative activity of flavone derivatives containing 1,2,4-triazole structure].
abstract: Using bioactive compounds 7-hydroxy flavone, salicylaldehyde, cinnamic acid and 4-amino-5- mercapto-1,2,4-triazoles as starting materials, three new types of flavone derivatives containing 1,2,4-triazole structure were synthesized via different step reactions. These new compounds were characterized by 1IHNMR, ESI-MS, IR and elemental analysis. Their scavenging effects on the superoxide radical (O2·-), hydroxyl radical (·OH), DPPH · radical and their total reduction activities were tested. The results showed that all of the compounds possessed some antioxidative activity at the concentration of 0.5 mg · mL(-1), but the scavenging ability of the target compounds was lower than that of the standard compound Vc.
authors.forename: Zhi-fang
authors.initials: ZF
authors.lastname: Duan
authors.forename: Ling
authors.initials: L
authors.lastname: Shao
authors.forename: Sai-nan
authors.initials: SN
authors.lastname: Li
mesh_terms: D002934:Cinnamates / Q000737:chemistry; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry
chemical_list: D002934:Cinnamates; D047309:Flavones; D005419:Flavonoids; D016166:Free Radical Scavengers; D014230:Triazoles; C029010:cinnamic acid; C045575:1,2,4-triazole; C429845:7-hydroxyflavone