title: [Clinical features of patients with juvenile and adult dermatomyositis].
abstract: BACKGROUND
  Juvenile and adult dermatomysitis are chronic, immune-mediated inflammatory myopathies characterized by progressive proximal muscle weakness and typical skin symptoms.
  
  
  OBJECTIVE
  To compare the symptoms, laboratory and serological findings, treatment and disease course in children and adults suffering from dermatomyositis.
  
  
  METHODS
  In this retrospective study, juvenile and adult dermatomyositis groups were formed. There were 27 patients with juvenile dermatomyositis (mean age, 8.7 years; mean follow-up time: 104.6 months) and 30 adult patients (mean age, 50.3; mean follow-up time: 58.1 months).
  
  
  RESULTS
  In patients with juvenile dermatomyositis, treatment with intravenous immunoglobulin and cyclosporine A were more frequent as compared to adult patients. Acute onset of the disease was more frequent in adult patients than in those with juvenile disease. In children symptoms of the disease developed gradually.
  
  
  CONCLUSIONS
  The findings confirm previously published data showing that there are differences between juvenile and adult patients with dermatomyositis. The authors recommend to follow the patients regularly after reaching remission to avoid bad patient compliance and decrease the number and severity of relapses.
authors.affiliation: Belgyógyászati Intézet, Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ, Általános Orvostudományi Kar Debrecen.
authors.forename: Orsolya
authors.initials: O
authors.lastname: Szalmás
authors.affiliation: Belgyógyászati Intézet, Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ, Általános Orvostudományi Kar Debrecen.
authors.forename: Melinda
authors.initials: M
authors.lastname: Nagy-Vince
authors.affiliation: Belgyógyászati Intézet, Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ, Általános Orvostudományi Kar Debrecen.
authors.forename: Katalin
authors.initials: K
authors.lastname: Dankó
authors.affiliation: Belgyógyászati Intézet, Klinikai Immunológiai Tanszék, Debreceni Egyetem, Klinikai Központ, Általános Orvostudományi Kar Debrecen.
authors.forename: Flóra
authors.initials: F
authors.lastname: Farkas
mesh_terms: D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use; D003882:Dermatomyositis / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D018908:Muscle Weakness / Q000209:etiology*; D012008:Recurrence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D001379:Azathioprine; D008775:Methylprednisolone; D008727:Methotrexate
keywords: calcinosis cutis; clinical immunology; dermatomyositis; intravenous immunoglobulin; intravénás immunglobulin; juvenile; juvenilis; klinikai immunológia