title: IL‑33 and kidney disease (Review).
abstract: Interleukin (IL)-33, is a novel member of the IL-1 superfamily, and act as a dual-function molecule as a nuclear factor and cytokine. The expression of IL-33 can be detected in several tissues and cells in humans and in mice. In addition to the conventional secretion approach for cytokines, full-length IL-33 can also be released into the extracellular space following cell damage or mechanical injury. IL-33 mediates its biological effects by interacting with the receptors, suppression of tumorigenicity 2 (ST2) and IL-1 receptor accessory protein, activating intracellular molecules in the nuclear factor-κB and mitogen-activated protein kinase signaling pathways, which drive the production of type 2 cytokines, including IL-4, IL-5 and IL-3, from polarized T helper 2 cells. Increasing evidence indicates that IL-33 is important in chronic kidney disease, and may be involved in the progression of renal fibrosis associated with systemic lupus erythematosus and renal graft damage. In addition, IL-33 contributes to acute kidney injury. In the present review, the biology of IL-33, and the association of IL-33 with kidney diseases are discussed.
authors.affiliation: Department of Nephrology, The First College of Clinical Medical Science, Three Gorges University, Yichang, Hubei 443003, P.R. China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Nephrology, The First College of Clinical Medical Science, Three Gorges University, Yichang, Hubei 443003, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.affiliation: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen, Fujian 361000, P.R. China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Duan
authors.affiliation: Department of Nephrology, The First College of Clinical Medical Science, Three Gorges University, Yichang, Hubei 443003, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Immunology, The First College of Clinical Medical Science, Three Gorges University, Yichang, Hubei 443003, P.R. China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D006801:Humans; D000067596:Interleukin-33 / Q000737:chemistry / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D008954:Models, Biological; D018123:Receptors, Interleukin / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000067596:Interleukin-33; D018123:Receptors, Interleukin