title: New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer.
abstract: A new bigenic mouse model, engineered with the overexpression of PSGR and the knockout of PTEN, has been used to study the relationship between 2 genes and disease progression. A study in Oncogene (Rodriguez et al.) has shown that these 2 genetic polymorphisms synergistically promote the development of prostate cancer.
authors.affiliation: a Genitourinary Malignancies Branch; Center for Cancer Research; National Cancer Institute; National Institutes of Health ; Bethesda ; MD , USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Polman
authors.affiliation: a Genitourinary Malignancies Branch; Center for Cancer Research; National Cancer Institute; National Institutes of Health ; Bethesda ; MD , USA.
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Price
authors.affiliation: a Genitourinary Malignancies Branch; Center for Cancer Research; National Cancer Institute; National Institutes of Health ; Bethesda ; MD , USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Figg
keywords: NF-κB pathway; PIK3/Akt pathway; PSGR; PTEN; bigenic mouse model; disease progression; genetic synergism; prostate cancer