title: Varenicline for Smoking Cessation in Hospitalized Patients With Acute Coronary Syndrome.
abstract: BACKGROUND
  Less than one-third of smokers hospitalized with an acute coronary syndrome (ACS) remain abstinent following discharge. We assessed whether varenicline, begun in-hospital, is efficacious for smoking cessation following ACS.
  
  
  RESULTS
  We conducted a multi-center, double-blind, randomized, placebo-controlled trial in which smokers hospitalized with an ACS were randomized to varenicline or placebo for 12 weeks. All patients received low-intensity counseling. The primary end point was point-prevalence smoking abstinence assessed at 24 weeks by 7-day recall and biochemical validation using expired carbon monoxide. A total of 302 patients were randomized (mean age 55±9 years; 75% male; 56% ST-segment elevation myocardial infarction; 38% non-ST-segment elevation myocardial infarction; 6% unstable angina). Patients smoked a mean of 21±11 cigarettes/d at the time of hospitalization and had been smoking for a mean of 36±12 years. At 24 weeks, patients randomized to varenicline had significantly higher rates of smoking abstinence and reduction than patients randomized to placebo. Point-prevalence abstinence rates were 47.3% in the varenicline group and 32.5% in the placebo group (P=0.012; number needed to treat=6.8). Continuous abstinence rates were 35.8% and 25.8%, respectively (P=0.081; number needed to treat=10.0), and rates of reduction ≥50% in daily cigarette consumption were 67.4% and 55.6%, respectively (P=0.05; number needed to treat=8.5). Adverse event rates within 30 days of study drug discontinuation were similar between groups (serious adverse events: varenicline 11.9%, placebo 11.3%; major adverse cardiovascular events: varenicline 4.0%, placebo 4.6%).
  
  
  CONCLUSIONS
  Varenicline, initiated in-hospital following ACS, is efficacious for smoking cessation. Future studies are needed to establish safety in these patients.
  
  
  BACKGROUND
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT00794573.
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.). mark.eisenberg@mcgill.ca.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Eisenberg
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Windle
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Nathalie
authors.initials: N
authors.lastname: Roy
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Wayne
authors.initials: W
authors.lastname: Old
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: François R
authors.initials: FR
authors.lastname: Grondin
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Iqbal
authors.initials: I
authors.lastname: Bata
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Ayman
authors.initials: A
authors.lastname: Iskander
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Claude
authors.initials: C
authors.lastname: Lauzon
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Nalin
authors.initials: N
authors.lastname: Srivastava
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Adam
authors.initials: A
authors.lastname: Clarke
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Daniel
authors.initials: D
authors.lastname: Cassavar
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Danielle
authors.initials: D
authors.lastname: Dion
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Herbert
authors.initials: H
authors.lastname: Haught
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Shamir R
authors.initials: SR
authors.lastname: Mehta
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Baril
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Charles
authors.initials: C
authors.lastname: Lambert
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Mina
authors.initials: M
authors.lastname: Madan
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Beth L
authors.initials: BL
authors.lastname: Abramson
authors.affiliation: From Jewish General Hospital/McGill University, Montréal, QC, Canada (M.J.E., S.B.W.); Centre de santé et de services sociaux de Chicoutimi, Chicoutimi, QC, Canada (N.R.); Sentara Cardiovascular Research Institute, Norfolk, VA (W.O.); CISSS Chaudière-Appalaches, Hôtel-Dieu de Lévis site, QC, Canada (F.R.G.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (I.B.); SJH Cardiology Associates and St. Joseph's Hospital, Liverpool, NY (A.I.); CISSS - Chaudière-Appalaches, Thetford Mines, QC, Canada (C.L.); Spartanburg Regional Medical Center, Spartanburg, SC (N.S.); Valley Regional Hospital, Kentville, NS (A.C.); ProMedica Toledo Hospital, Toledo, OH (D.C.); CISSS de Chaudière Appalaches site Hôpital St-Georges, Beauce, QC, Canada (D.D.); Heart Center Research, Huntsville, AL (H.H.); McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (S.R.M.); Dr. Georges-L.-Dumont University Hospital Centre, Moncton, NB, Canada (J.-F.B.); Florida Hospital Pepin Heart Institute, Tampa, FL (C.L.); Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada (M.M.);St. Michael's Hospital, Toronto, ON, Canada (B.L.A.); Prairie Vascular Research Network, University of Saskatchewan, Regina, SK, Canada (P.D.).
authors.forename: Payam
authors.initials: P
authors.lastname: Dehghani
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000639:trends; D006801:Humans; D008297:Male; D008875:Middle Aged; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D016540:Smoking Cessation / Q000379:methods*; D061485:Tobacco Use Cessation Devices / Q000639:trends; D000068580:Varenicline / Q000627:therapeutic use*
chemical_list: D018722:Nicotinic Agonists; D000068580:Varenicline
keywords: acute coronary syndrome; smoking