title: A Case of Special Complication following a Large Amount of Polyacrylamide Hydrogel Injected into the Epicranial Aponeurosis: Leukocytopenia.
abstract: Polyacrylamide hydrogel (PAAG) has been used as an injectable filler for soft tissue augmentation of different body parts, such as the face, breasts, and penis. However, this is the first report of leukocytopenia after injection of a large amount of PAAG in the epicranial aponeurosis. After receiving PAAG injection for craniofacial contouring, the female patient described herein experienced recurrent swelling, temporal pain (particularly with changes in ambient temperature and facial expression), and ultimately leukocytopenia due to widespread migration of the injected PAAG. We removed most of the PAAG from the affected tissues and the leukocytopenia disappeared 1 year after the operation. Based on this case, we hypothesize that injection of a large amount of PAAG into tissues that have ample blood supply, such as the epicranial aponeurosis, may induce leukocytopenia.
authors.affiliation: Department of Plastic and Aesthetic Surgery, First Hospital of Jilin University, Chaoyang District, Changchun, Jilin 130021, China.
authors.forename: Li
authors.initials: L
authors.lastname: Rong
authors.affiliation: Department of Hematology and Oncology, First Hospital of Jilin University, Chaoyang District, Changchun, Jilin 130021, China.
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Lan
authors.affiliation: Department of Plastic and Aesthetic Surgery, First Hospital of Jilin University, Chaoyang District, Changchun, Jilin 130021, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Plastic and Aesthetic Surgery, First Hospital of Jilin University, Chaoyang District, Changchun, Jilin 130021, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Plastic and Aesthetic Surgery, First Hospital of Jilin University, Chaoyang District, Changchun, Jilin 130021, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Zhang