title: Composite chitosan/alginate hydrogel for controlled release of deferoxamine: A system to potentially treat iron dysregulation diseases.
abstract: Recently, the potential application of deferoxamine (DFO) in several iron dysregulation diseases has been highlighted. However, DFO presents significant limitations in clinical use due to its poor absorption in the gut and very short plasma half-life. To overcome these problems, the feasibility of chitosan/alginate hydrogels as prolonged delivery systems of DFO was investigated. Hydrogel alone or co-formulated with poly(D,L-lactide-co-glycolide) microspheres were prepared and studied in vitro. The influence of the preparation methods on the performance of composite hydrogels on controlled DFO release was explored. Spray-dried microspheres based on poly(D,L-lactide-co-glycolide) were able to encapsulate DFO, a highly water soluble drug. Nevertheless, only the composite hydrogels managed to provide sustained drug release. The inclusion of microspheres into pre-formed chitosan/alginate hydrogel provided the most efficient delivery system; the drug released from microspheres is strongly entrapped in the hydrogel network and slowly released by diffusion.
authors.affiliation: Department of Chemistry and Pharmacy, University of Sassari, via Muroni 23, 07100 Sassari, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Rassu
authors.affiliation: Department of Chemistry and Pharmacy, University of Sassari, via Muroni 23, 07100 Sassari, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Salis
authors.affiliation: PhD Student in Experimental Medicine, University of Pavia, Pavia, Italy.
authors.forename: Elena Piera
authors.initials: EP
authors.lastname: Porcu
authors.affiliation: Department of Chemistry and Pharmacy, University of Sassari, via Muroni 23, 07100 Sassari, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Giunchedi
authors.affiliation: Institute of Biomedical and Biomolecular Science, University of Portsmouth,St Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK.
authors.forename: Marta
authors.initials: M
authors.lastname: Roldo
authors.affiliation: Department of Chemistry and Pharmacy, University of Sassari, via Muroni 23, 07100 Sassari, Italy. Electronic address: eligav@uniss.it.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Gavini
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D003676:Deferoxamine / Q000737:chemistry* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D007501:Iron / Q000378:metabolism*; D019344:Lactic Acid / Q000737:chemistry; D008659:Metabolic Diseases / Q000188:drug therapy*; D008863:Microspheres; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D014783:Viscosity
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D020100:Hydrogels; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D020723:Glucuronic Acid; D048271:Chitosan; D007501:Iron; D003676:Deferoxamine
keywords: Alginate; Chitosan; Chitosan (PubChem CID: 21896651); Composite hydrogel; Deferoxamine; Deferoxamine mesylate (PubChem CID: 62881); Iron dysregulation diseases; PLGA microparticles; Poly(d,l-lactide-co-glycolide) (PubChem CID: 23111554); Sodium alginate (PubChem CID: 6850754)