title: Platelet aggregation in response to ADP is highly variable in normal donors and patients on anti-platelet medication.
abstract: BACKGROUND
  P2Y12 inhibitors are indicated in patients following percutaneous coronary intervention. Several studies have demonstrated that high on treatment platelet reactivity is correlated with outcomes yet prospective studies of guided therapy have failed to show benefit. There is a paucity of studies on the platelet aggregation response to ADP before P2Y12 therapy is started. The aim of this study was to characterize platelet responses to 20 μM ADP by light transmission aggregometry (LTA) in a homogenous population.
  
  
  METHODS
  Platelet aggregation was assessed in 201 patients on dual antiplatelet therapy, 98 patients on aspirin alone and 47 normal, healthy volunteers free from anti-platelet medication.
  
  
  RESULTS
  Consensus guidelines suggest that a platelet aggregation response in response to the agonist ADP of <57% is an adequate therapeutic response to P2Y12 inhibition. Seven healthy donors and 38 patients taking aspirin only had aggregation responses below 57%.
  
  
  CONCLUSIONS
  The results of our study demonstrate that 15% of normal donors and 38% of patients taking aspirin only would be classified as having a therapeutic response to P2Y12 inhibition using current guidelines.
authors.forename: Eimear
authors.identifier: http://orcid.org/0000-0001-9862-1398
authors.initials: E
authors.lastname: Dunne
authors.forename: Karl
authors.initials: K
authors.lastname: Egan
authors.forename: Siobhán
authors.initials: S
authors.lastname: McFadden
authors.forename: David
authors.initials: D
authors.lastname: Foley
authors.forename: Dermot
authors.initials: D
authors.lastname: Kenny
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000368:Aged; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010979:Platelet Function Tests
chemical_list: D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D001241:Aspirin