title: Metabolic Determinants of Mitochondrial Function in Oocytes.
abstract: Mitochondrial production of cellular energy is essential to oocyte function, zygote development and successful continuation of pregnancy. This review focuses on several key functions of healthy oocyte mitochondria and the effect of pathologic states such as aging, oxidative stress and apoptosis on these functions. The effect of these abnormal conditions is presented in terms of clinical presentations, specifically maternal obesity, diminished ovarian reserve and assisted reproductive technologies.
authors.affiliation: Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Seidler
authors.affiliation: Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Kelle H
authors.initials: KH
authors.lastname: Moley
mesh_terms: D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D017209:Apoptosis; D020013:Calcium Signaling; D016922:Cellular Senescence / Q000235:genetics; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D004734:Energy Metabolism / Q000235:genetics; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D009865:Oocytes / Q000378:metabolism* / Q000473:pathology; D065851:Ovarian Reserve; D010053:Ovary / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted
chemical_list: D004272:DNA, Mitochondrial