title: Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration.
abstract: The metastatic disease is one of the main consequences of tumor progression, being responsible for most cancer-related deaths worldwide. This review intends to present and discuss data on the relationship between integrins and heparan sulfate proteoglycans in health and cancer progression. Integrins are a family of cell surface transmembrane receptors, responsible for cell-matrix and cell-cell adhesion. Integrins' main functions include cell adhesion, migration, and survival. Heparan sulfate proteoglycans (HSPGs) are cell surface molecules that play important roles as cell receptors, cofactors, and overall direct or indirect contributors to cell organization. Both molecules can act in conjunction to modulate cell behavior and affect malignancy. In this review, we will discuss the different contexts in which various integrins, such as α5, αV, β1, and β3, interact with HSPGs species, such as syndecans and perlecans, affecting tissue homeostasis.
authors.affiliation: Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil.
authors.forename: Mariana A
authors.initials: MA
authors.lastname: Soares
authors.affiliation: Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil.
authors.forename: Felipe C O B
authors.initials: FC
authors.lastname: Teixeira
authors.affiliation: Serviço de Patologia, Hospital Naval Marcílio Dias, 20725-090 Rio de Janeiro, RJ, Brazil.
authors.forename: Miguel
authors.initials: M
authors.lastname: Fontes
authors.affiliation: Serviço de Patologia, Hospital Naval Marcílio Dias, 20725-090 Rio de Janeiro, RJ, Brazil.
authors.forename: Ana Lúcia
authors.initials: AL
authors.lastname: Arêas
authors.affiliation: Hospital Naval Marcílio Dias, Instituto de Pesquisas Biomédicas, 20725-090 Rio de Janeiro, RJ, Brazil.
authors.forename: Marcelo G
authors.initials: MG
authors.lastname: Leal
authors.affiliation: Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil.
authors.forename: Mauro S G
authors.initials: MS
authors.lastname: Pavão
authors.affiliation: Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil.
authors.forename: Mariana P
authors.initials: MP
authors.lastname: Stelling
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D019812:Heparan Sulfate Proteoglycans; D016023:Integrins