title: A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO.
abstract: A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembly of graphene oxide (GO) nanosheets and a NO donor BNN6 through the π-π stacking interaction. The GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, irradiation time and power density of NIR laser. The intracellular NIR-responsive release of NO from the GO-BNN6 nanomedicine causes a remarkable anti-cancer effect.
authors.affiliation: State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, Jiangsu, P. R. China. nyhe1958@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Fan
authors.forename: Nongyue
authors.initials: N
authors.lastname: He
authors.forename: Qianjun
authors.initials: Q
authors.lastname: He
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.forename: Xiao
authors.initials: X
authors.lastname: Fu
authors.forename: Yijing
authors.initials: Y
authors.lastname: Liu
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D002470:Cell Survival; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005434:Flow Cytometry; D006108:Graphite / Q000737:chemistry; D006801:Humans; D018625:Microscopy, Atomic Force; D008856:Microscopy, Fluorescence; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000473:pathology*; D009569:Nitric Oxide / Q000737:chemistry*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010087:Oxides / Q000737:chemistry; D010777:Photochemistry / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared; D019265:Spectroscopy, Near-Infrared
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010087:Oxides; D009569:Nitric Oxide; D006108:Graphite; D019001:Nitric Oxide Synthase