title: Clinical, endoscopic, and pathologic characteristics of colorectal polyps in Indian children and adolescents.
abstract: OBJECTIVE
  Colorectal polyps are among the common causes for rectal bleeding in children. We studied the clinical, colonoscopic, and histopathological features of colorectal polyps and polyposis syndrome in Indian children and adolescents.
  
  
  METHODS
  Medical records of children and adolescents with colorectal polyps and polyposis syndrome were retrospectively reviewed from 2001 to 2014 at Department of Gastroenterology, in large tertiary care center of Mumbai.
  
  
  RESULTS
  A total of 120 patients were found to have colonic polyps during study period. Mean age of presentation in children was 7.31 ± 4.05 years (range 2 to 19 years), with male-to-female ratio of 2.16:1. Rectal bleeding was presenting symptom in 95.8 % with mean duration of 12.6 ± 15 months. Majority of polyps (77.5 %) were juvenile, and 97.2 % were located in left colon. Solitary polyps were seen in 76.6 %, multiple polyps in 11.6 %, juvenile polyposis syndrome in 6.6 %, familial adenomatous polyposis in 4.2 %, and Peutz-Jeghers syndrome in 0.8 % of the children. The polyposis syndrome group had higher age at presentation (p = 0.00006), greater likelihood of anemia, abdominal pain, and diarrhea (p = 0.0001, 0.0002, and 0.0051, respectively). Likelihood of adenomatous change in polyps was higher in polyposis syndrome group (p = 0.0003). Left colonic polyps were more common in non-polyposis group, whereas pan-colonic polyps were more common in polyposis syndrome group (p < 0.00001).
  
  
  CONCLUSIONS
  Presence of anemia, abdominal pain, diarrhea, higher age at presentation (more than 10 years), and history of polypectomy are clinical indicators of polyposis syndrome.
authors.affiliation: Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, 400 022, India. cdrathi@gmail.com.
authors.forename: Chetan
authors.initials: C
authors.lastname: Rathi
authors.affiliation: Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, 400 022, India.
authors.forename: Meghraj
authors.initials: M
authors.lastname: Ingle
authors.affiliation: Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, 400 022, India.
authors.forename: Nilesh
authors.initials: N
authors.lastname: Pandav
authors.affiliation: Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, 400 022, India.
authors.forename: Nirav
authors.initials: N
authors.lastname: Pipaliya
authors.affiliation: Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, 400 022, India.
authors.forename: Dhaval
authors.initials: D
authors.lastname: Choksi
authors.affiliation: Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, 400 022, India.
authors.forename: Prabha
authors.initials: P
authors.lastname: Sawant
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D000367:Age Factors; D000740:Anemia / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003111:Colonic Polyps / Q000150:complications / Q000473:pathology* / Q000601:surgery; D003967:Diarrhea / Q000209:etiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D012002:Rectal Diseases / Q000209:etiology; D013577:Syndrome; D055815:Young Adult
keywords: Colorectal disease; Juvenile polyps; Polyps