title: A Familial Pattern of Multiple Idiopathic Cervical Root Resorption With a 30-Year Follow-Up.
abstract: BACKGROUND
  Multiple idiopathic cervical root resorption (MICRR) is a rare entity distinct from pathologic root resorption that occurs as a result of several local and systemic factors.
  
  
  METHODS
  This report describes a familial pattern of MICRR, including a recently identified case and a 30-year follow-up on previously described cases.
  
  
  RESULTS
  The previously reported father (aged 95 years) and son (aged 64 years), and the recently affected daughter (aged 61 years) recounted non-contributory medical history. The resorptive lesions were asymptomatic, unassociated with any predisposing factors, and first identified during the fourth to sixth decades of life. All tooth types were affected, with posterior teeth being affected earlier and with greater frequency; however, distal root surfaces were never affected. The resorptive lesions were progressive in nature, with additional teeth becoming involved as the condition was followed over time. In many instances, surrounding alveolar bone extended into the existing resorptive defects, but without clinical evidence of ankylosis. Gingival tissues, periodontal probing, and tooth mobility were within normal limits. Microcomputed tomography of extracted teeth demonstrated that the lesions were more extensive than clinically evident and rarely invaded the pulp chamber. Histologically, many resorptive lesions were noted along the cementum surface, with evidence of isolated cemental repair. Management of MICRR focused on restoring damaged root surfaces and extracting teeth with extensive root resorption.
  
  
  CONCLUSIONS
  MICRR is a challenging entity with unknown etiology and a lack of well-established preventive and management strategies. The familial pattern noted in this report necessitates future studies to investigate the role of genetic components in MICRR development.
authors.affiliation: Department of Periodontology and Dental Hygiene, School of Dentistry, University of Detroit Mercy, Detroit, MI.
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Neely
authors.affiliation: Laboratory of Oral and Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD.
authors.forename: Vivek
authors.initials: V
authors.lastname: Thumbigere-Math
authors.affiliation: Laboratory of Oral and Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD.
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Somerman
authors.affiliation: Currently, Biosciences Division, College of Dentistry, The Ohio State University, Columbus, OH; previously, Laboratory of Oral and Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health.
authors.forename: Brian L
authors.initials: BL
authors.lastname: Foster
mesh_terms: D003739:Dental Cementum; D005500:Follow-Up Studies; D006801:Humans; D012391:Root Resorption; D014092:Tooth Root; D055114:X-Ray Microtomography / Q000009:adverse effects
keywords: Dental cementum; root resorption; tooth; tooth loss; tooth resorption; x-ray microtomography