title: Endosonography guided management of pancreatic fluid collections.
abstract: The revised Atlanta classification of acute pancreatitis was adopted by international consensus, and is based on actual local and systemic determinants of disease severity. The local determinant is pancreatic necrosis (sterile or infected), and the systemic determinant is organ failure. Local complications of pancreatitis can include acute peri-pancreatic fluid collection, acute necrotic collection, pseudocyst formation, and walled-off necrosis. Interventional endoscopic ultrasound (EUS) has been increasing utilized in managing these local complications. After performing a PubMed search, the authors manually applied pre-defined inclusion criteria or a filter to identify publications relevant to EUS and pancreatic collections (PFCs). The authors then reviewed the utility, efficacy, and risks associated with using therapeutic EUS and involved EUS devices in treating PFCs. Due to the development and regulatory approval of improved and novel endoscopic devices specifically designed for transmural drainage of fluid and necrotic debris (access and patency devices), the authors predict continuing evolution in the management of PFCs. We believe that EUS will become an indispensable part of procedures used to diagnose PFCs and perform image-guided interventions. After draining a PFC, the amount of tissue necrosis is the most important predictor of a successful outcome. Hence, it seems logical to classify these collections based on their percentage of necrotic component or debris present when viewed by imaging methods or EUS. Finally, the authors propose an algorithm for managing fluid collections based on their size, location, associated symptoms, internal echogenic patterns, and content.
authors.affiliation: Andreas S Vilmann, Peter Vilmann, Department of Surgical Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark.
authors.forename: Andreas S
authors.initials: AS
authors.lastname: Vilmann
authors.affiliation: Andreas S Vilmann, Peter Vilmann, Department of Surgical Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark.
authors.forename: John
authors.initials: J
authors.lastname: Menachery
authors.affiliation: Andreas S Vilmann, Peter Vilmann, Department of Surgical Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark.
authors.forename: Shou-Jiang
authors.initials: SJ
authors.lastname: Tang
authors.affiliation: Andreas S Vilmann, Peter Vilmann, Department of Surgical Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark.
authors.forename: Indu
authors.initials: I
authors.lastname: Srinivasan
authors.affiliation: Andreas S Vilmann, Peter Vilmann, Department of Surgical Gastroenterology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Vilmann
mesh_terms: D000208:Acute Disease; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D004322:Drainage / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D019160:Endosonography / Q000009:adverse effects; D006801:Humans; D010195:Pancreatitis / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy*; D018579:Patient Selection; D011474:Prosthesis Design; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000009:adverse effects / Q000379:methods*
keywords: Abscess; Drainage; Endoscopic ultrasound; Pancreas; Pancreatic fluid collection; Patency device; Pseudocyst; Walled of necrosis