title: Speciation of precious metal anti-cancer complexes by NMR spectroscopy.
abstract: Understanding the mechanism of action of anti-cancer agents is of paramount importance for drug development. NMR spectroscopy can provide insights into the kinetics and thermodynamics of the binding of metallodrugs to biomolecules. NMR is most sensitive for highly abundant I=1/2 nuclei with large magnetic moments. Polarization transfer can enhance NMR signals of insensitive nuclei at physiologically-relevant concentrations. This paper reviews NMR methods for speciation of precious metal anti-cancer complexes, including platinum-group and gold-based anti-cancer agents. Examples of NMR studies involving interactions with DNA and proteins in particular are highlighted.
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK; State Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Taotao
authors.initials: T
authors.lastname: Zou
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK. Electronic address: P.J.Sadler@warwick.ac.uk.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sadler
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019216:Metals, Heavy / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D010984:Platinum / Q000737:chemistry / Q000627:therapeutic use; D012238:Rhodium / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D019216:Metals, Heavy; D010984:Platinum; D006046:Gold; D012238:Rhodium