title: A new way to target p53-defective colorectal cancer.
authors.affiliation: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Yunhua
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Liana
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Xiongbin
authors.initials: X
authors.lastname: Lu
mesh_terms: D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D023281:Genomics; D057898:Hemizygote; D006801:Humans; D058990:Molecular Targeted Therapy; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency*
chemical_list: D016159:Tumor Suppressor Protein p53; D012319:RNA Polymerase II
keywords: POLR2A; colorectal cancer; hemizygous loss; p53; tumor suppressor gene; α-amanitin