title: Potential of agricultural fungicides for antifungal drug discovery.
abstract: While it is true that only a small fraction of fungal species are responsible for human mycoses, the increasing prevalence of fungal diseases has highlighted an urgent need to develop new antifungal drugs, especially for systemic administration. This contribution focuses on the similarities between agricultural fungicides and drugs. Inorganic, organometallic and organic compounds can be found amongst agricultural fungicides. Furthermore, fungicides are designed and developed in a similar fashion to drugs based on similar rules and guidelines, with fungicides also having to meet similar criteria of lead-likeness and/or drug-likeness. Modern approved specific-target fungicides are well-characterized entities with a proposed structure-activity relationships hypothesis and a defined mode of action. Extensive toxicological evaluation, including mammalian toxicology assays, is performed during the whole discovery and development process. Thus modern agrochemical research (design of modern agrochemicals) comes close to drug design, discovery and development. Therefore, modern specific-target fungicides represent excellent lead-like structures/models for novel drug design and development.
authors.affiliation: a Department of Chemical Drugs, Faculty of Pharmacy , University of Veterinary and Pharmaceutical Sciences , Brno , Czech Republic.
authors.forename: Josef
authors.initials: J
authors.lastname: Jampilek
mesh_terms: D016573:Agrochemicals / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D005658:Fungi / Q000187:drug effects; D005659:Fungicides, Industrial / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D016573:Agrochemicals; D000935:Antifungal Agents; D005659:Fungicides, Industrial
keywords: agricultural fungicides; antifungal drugs; drug design and discovery; drug-likeness; lead-likeness; mycoses