title: Synthesis of alginate derivative via the Ugi reaction and its characterization.
abstract: In this research, the systematic evaluation of fundamental properties of the alginate derivative (Ugi-Alg) synthesized by the Ugi reaction is presented. The structure of Ugi-Alg with the degree of substitution of 23.24% was confirmed by FT-IR and (1)H NMR spectrometers. The X-ray diffraction (XRD) results indicate the amorphous structure and the crystal structure change of Ugi-Alg, which is possibly ascribed to the destruction of inter- and intra-molecular hydrogen bonding interactions during the Ugi reaction. From thermal gravimetric analysis (TGA) and fluorescence spectrophotometer, Ugi-Alg shows high thermal stability and good amphiphilic functionality with the critical aggregation concentration of 0.07 g/L in 0.15 mol/L aqueous NaCl solution. Transmission electron microscope (TEM) image and dynamic light scattering (DLS) reveal that stable Ugi-Alg self-aggregated micelle with the average size of 162.3 nm and ζ potential at about -31.7 mV could form in the aqueous media, which presents tremendous potential in pharmacology and tissue engineering.
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Huiqiong
authors.initials: H
authors.lastname: Yan
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Xiuqiong
authors.initials: X
authors.lastname: Chen
authors.affiliation: College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China.
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China. Electronic address: hn136.631@163.com.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Feng
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Zaifeng
authors.initials: Z
authors.lastname: Shi
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China.
authors.forename: Xianghui
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China. Electronic address: linqianggroup@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lin
mesh_terms: D000464:Alginates / Q000737:chemistry*; D008823:Micelles; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000464:Alginates; D008823:Micelles; D013501:Surface-Active Agents
keywords: Alginate derivative; Amphiphilic functionality; Self-aggregated micelle; Ugi reaction