title: [Value of pancreatic stone protein/regenerating protein in severity evaluation and prognosis prediction for children with sepsis].
abstract: OBJECTIVE
  To evaluate the value of pancreatic stone protein/regenerating protein (PSP/reg) in severity evaluation and prognosis prediction for children with sepsis.
  
  
  METHODS
  In this prospective case-control study, 159 children with sepsis (106 cases in the sepsis group; 53 cases in the severe sepsis group, including 12 cases of septic shock) and 20 children without sepsis (control group) were enrolled. ELISA was applied to measure plasma PSP/reg levels on days 1, 3, and 7 of admission to the PICU. The Spearman rank correlation test was applied to assess the correlations between plasma PSP/reg level and serum procalcitonin (PCT), CRP, WBC count, and pediatric critical illness score (PCIS). The area under the receiver operating characteristic curve (AUC) was used to assess the value of each index in determining severity and predicting prognosis for children with sepsis.
  
  
  RESULTS
  On day 1 of admission to the PICU, plasma PSP/reg levels in the sepsis and severe sepsis groups were significantly higher than in the control group (P<0.05), and the severe sepsis group had a significantly higher plasma PSP/reg level than the sepsis group (P<0.05). On day 1 of admission to the PICU, the survival group (n=132) had a significantly lower plasma PSP/reg level than the non-survival group (n=27) (P<0.05). On day 1 of admission to the PICU, plasma PSP/reg level in children with sepsis was positively correlated with WBC count and serum PCT level (rs=0.212 and 0.548, respectively; both P<0.05), and negatively correlated with PCIS score (rs=-0.373; P<0.05). The AUCs of plasma PSP/reg level and serum PCT for determination of severe sepsis, septic shock, and death were higher than 0.7 (P<0.05).
  
  
  CONCLUSIONS
  PSP/reg is closely related to infection, and has a certain clinical value in risk stratification of sepsis and prognosis evaluation.
authors.affiliation: Emergency Center, Hunan Children's Hospital, Nanhua University, Changsha 410007, China. cszhuyimin@163.com.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Peng
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Zhu
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Zhang
authors.forename: Xia-Yan
authors.initials: XY
authors.lastname: Kang
mesh_terms: D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051847:Lithostathine / Q000097:blood*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood; D018805:Sepsis / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: C000606589:CALCA protein, human; D051847:Lithostathine; D011498:Protein Precursors; C497617:REG1A protein, human; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide