title: Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels.
abstract: A highly elastic hybrid hydrogel of methacryloyl-substituted recombinant human tropoelastin (MeTro) and graphene oxide (GO) nanoparticles are developed. The synergistic effect of these two materials significantly enhances both ultimate strain (250%), reversible rotation (9700°), and the fracture energy (38.8 ± 0.8 J m(-2) ) in the hybrid network. Furthermore, improved electrical signal propagation and subsequent contraction of the muscles connected by hybrid hydrogels are observed in ex vivo tests.
authors.affiliation: Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|Department of Chemical Engineering, Northeastern University, Boston, MA, 02115-5000, USA.
authors.forename: Nasim
authors.initials: N
authors.lastname: Annabi
authors.affiliation: Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
authors.forename: Su Ryon
authors.initials: SR
authors.lastname: Shin
authors.affiliation: Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Tamayol
authors.affiliation: Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Miscuglio
authors.affiliation: Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Mohsen Afshar
authors.initials: MA
authors.lastname: Bakooshli
authors.affiliation: Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|Department of Cardiovascular Surgery, Heinrich Heine University, 40225, Düsseldorf, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Assmann
authors.affiliation: Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Pooria
authors.initials: P
authors.lastname: Mostafalu
authors.affiliation: Department of Material Science and Engineering, Seoul National University, Seoul, 151-742, South Korea.
authors.forename: Jeong-Yun
authors.initials: JY
authors.lastname: Sun
authors.affiliation: Molecular Bioscience, Charles Perkins Centre, Bosch Institute, University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Mithieux
authors.affiliation: Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
authors.forename: Louis
authors.initials: L
authors.lastname: Cheung
authors.affiliation: Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
authors.forename: Xiaowu Shirley
authors.initials: XS
authors.lastname: Tang
authors.affiliation: Molecular Bioscience, Charles Perkins Centre, Bosch Institute, University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Weiss
authors.affiliation: Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.|Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D004548:Elasticity; D004553:Electric Conductivity; D004738:Engineering; D006108:Graphite / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010087:Oxides / Q000737:chemistry; D013718:Tensile Strength; D014333:Tropoelastin / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D010087:Oxides; D014333:Tropoelastin; D006108:Graphite
keywords: cardiac tissue engineering; elasticity; graphene oxides; hydrogels; tropoelastins