title: Suture Versus Mesh Repair in Primary and Incisional Ventral Hernias: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  Today, ventral hernia repair is predominantly performed with meshes. There is no meta-analysis of high quality evidence that compares the results of suture to mesh repair. The objective of this systematic review with meta-analysis is to compare patient centred outcomes of suture versus mesh repair.
  
  
  METHODS
  A systematic literature search was performed in EMBASE, MEDLINE and CENTRAL (inception to 06/2014). Furthermore a hand search was performed. RCTs comparing suture versus mesh repair in primary and incisional ventral hernia repair were included. Data on patient characteristics, interventions and results were extracted in standardized tables. Risk of bias was assessed with the cochrane risk of bias tool. Results of studies were pooled with a meta-analysis. All steps were performed by two reviewers. Discrepancies were discussed until a consensus.
  
  
  RESULTS
  The search in the databases resulted in 1560 hits. After screening, 10 randomized controlled trials including 1215 patients satisfied all inclusion criteria. Risk of bias was moderate to high. The relative risk for recurrence was 0.36 [95% CI (0.27, 0.49); I (2) = 0; heterogeneity p = 0.70]. Other complications did not differ significantly. Results for chronic pain were heterogeneous across studies.
  
  
  CONCLUSIONS
  Mesh repair reduces the number of recurrences significantly. In patients without recurrence mesh repairs seem to be associated with a risk of chronic pain especially if the mesh is fixed sublay.
authors.affiliation: Faculty of Health-School of Medicine, Institute for Research in Operative Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, Building 33, 51109, Cologne, Germany. tim.mathes@uni-wh.de.
authors.forename: Tim
authors.initials: T
authors.lastname: Mathes
authors.affiliation: Faculty of Health-School of Medicine, Institute for Research in Operative Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, Building 33, 51109, Cologne, Germany.
authors.forename: Maren
authors.initials: M
authors.lastname: Walgenbach
authors.affiliation: Department of General, Visceral and Cancer Surgery, HELIOS Klinikum Berlin-Buch and Faculty of Health-Witten/Herdecke University, HELIOS Klinikum, Schwanebecker Chaussee 50, 13125, Berlin, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Siegel
mesh_terms: D059350:Chronic Pain / Q000453:epidemiology; D006555:Hernia, Ventral / Q000601:surgery*; D059685:Herniorrhaphy / Q000379:methods*; D006801:Humans; D000069290:Incisional Hernia / Q000601:surgery*; D010149:Postoperative Pain / Q000453:epidemiology; D063868:Patient Outcome Assessment; D011183:Postoperative Complications / Q000453:epidemiology; D012008:Recurrence; D013526:Surgical Mesh; D013537:Sutures