title: Chikungunya vaccines in development.
abstract: Chikungunya virus has become a global health threat, spreading to the industrial world of Europe and the Americas; no treatment or prophylactic vaccine is available. Since the late 1960s much effort has been put into the development of a vaccine, and several heterogeneous strategies have already been explored. Only two candidates have recently qualified to enter clinical phase II trials, a chikungunya virus-like particle-based vaccine and a recombinant live attenuated measles virus-vectored vaccine. This review focuses on the current status of vaccine development against chikungunya virus in humans and discusses the diversity of immunization strategies, results of recent human trials and promising vaccine candidates.
authors.affiliation: a Departments of Clinical Pharmacology and Internal Medicine I , Medical University of Vienna , Vienna , Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Schwameis
authors.affiliation: a Departments of Clinical Pharmacology and Internal Medicine I , Medical University of Vienna , Vienna , Austria.
authors.forename: Nina
authors.initials: N
authors.lastname: Buchtele
authors.affiliation: a Departments of Clinical Pharmacology and Internal Medicine I , Medical University of Vienna , Vienna , Austria.
authors.forename: Patricia Pia
authors.initials: PP
authors.lastname: Wadowski
authors.affiliation: b Internal Medicine I Medical University of Vienna , Vienna , Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Schoergenhofer
authors.affiliation: a Departments of Clinical Pharmacology and Internal Medicine I , Medical University of Vienna , Vienna , Austria.
authors.forename: Bernd
authors.initials: B
authors.lastname: Jilma
mesh_terms: D065632:Chikungunya Fever / Q000453:epidemiology* / Q000517:prevention & control*; D017322:Clinical Trials, Phase II as Topic; D055808:Drug Discovery / Q000639:trends*; D014943:Global Health; D006801:Humans; D014765:Viral Vaccines / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D014765:Viral Vaccines
keywords: Chikungunya; clinical trials; live virus vaccine; measles virus; review; virus-like particles