title: Digital Dermatitis in Cattle: Current Bacterial and Immunological Findings.
abstract: Globally; digital dermatitis is a leading form of lameness observed in production dairy cattle. While the precise etiology remains to be determined; the disease is clearly associated with infection by numerous species of treponemes; in addition to other anaerobic bacteria. The goal of this review article is to provide an overview of the current literature; focusing on discussion of the polybacterial nature of the digital dermatitis disease complex and host immune response. Several phylotypes of treponemes have been identified; some of which correlate with location in the lesion and some with stages of lesion development. Local innate immune responses may contribute to the proliferative, inflammatory conditions that perpetuate digital dermatitis lesions. While serum antibody is produced to bacterial antigens in the lesions, little is known about cellular-based immunity. Studies are still required to delineate the pathogenic traits of treponemes associated with digital dermatitis; and other host factors that mediate pathology and protection of digital dermatitis lesions.
authors.affiliation: Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA. jennifer.wilson-welder@ars.usda.gov.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Wilson-Welder
authors.affiliation: Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA. david.alt@ars.usda.gov.
authors.forename: David P
authors.initials: DP
authors.lastname: Alt
authors.affiliation: Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA. jarlath.nally@ars.usda.gov.
authors.forename: Jarlath E
authors.initials: JE
authors.lastname: Nally
keywords: anaerobes; dairy cattle; digital dermatitis; immune response; treponemes