title: Spontaneous brain activity following fear reminder of fear conditioning by using resting-state functional MRI.
abstract: Although disrupting reconsolidation may be a promising approach to attenuate or erase the expression of fear memory, it is not clear how the neural state following fear reminder contribute to the following fear extinction. To address this question, we used resting-state functional magnetic resonance imaging (rs-fMRI) to measure spontaneous neuronal activity and functional connectivity (RSFC) following fear reminder. Some brain regions such as dorsal anterior cingulate (dACC) and ventromedial prefrontal cortex (vmPFC) showed increased amplitude of LFF (ALFF) in the fear reminder group than the no reminder group following fear reminder. More importantly, there was much stronger functional connectivity between the amygdala and vmPFC in the fear reminder group than those in the no reminder group. These findings suggest that the strong functional connectivity between vmPFC and amygdala following a fear reminder could serve as a key role in the followed-up fear extinction stages, which may contribute to the erasing of fear memory.
authors.affiliation: Faculty of Psychology, Southwest University, Chongqing 400715, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Feng
authors.affiliation: Faculty of Psychology, Southwest University, Chongqing 400715, China.|Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Faculty of Psychology, Southwest University, Chongqing 400715, China.|Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China.
authors.forename: Tingyong
authors.initials: T
authors.lastname: Feng
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003214:Conditioning, Classical; D005239:Fear; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory; D011939:Mental Recall; D010775:Photic Stimulation; D055815:Young Adult