title: Effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction.
abstract: The influence of glucagon-like peptide-1 has been studied in several studies in patients with acute myocardial infarction, but not in patients with non-ST-segment elevation myocardial infarction (NSTEMI). We planned to evaluate the effects of liraglutide on left ventricular function in patients with NSTEMI. A total of 90 patients were randomized 1:1 to receive either liraglutide (0.6 mg for 2 days, 1.2 mg for 2 days, followed by 1.8 mg for 3 days) or placebo for 7 days. Eighty-three patients completed the trial. Transthoracic echocardiography was used to assess left ventricular function. At 3 months, the primary endpoint, the difference in the change in left ventricular ejection fraction between the two groups was +4.7 % (liraglutide vs. placebo 95 % CI +0.7 to +9.2 % P = 0.009) under intention-to-treat analysis. The difference in decrease in serum glycosylated hemoglobin levels was -0.2 % (liraglutide vs. placebo 95 % CI -0.1 to -0.3 %; P < 0.001). Inflammation and oxidative stress improved significantly in the liraglutide group compared to the placebo group. Liraglutide could improve left ventricular function in patients with NSTEMI, making it a potential adjuvant therapy for NSTEMI.
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, Beijing, China.
authors.forename: Wei-Ren
authors.initials: WR
authors.lastname: Chen
authors.affiliation: International Medical Centre, PLA General Hospital at Beijing, Beijing, China.
authors.forename: Xue-Qin
authors.initials: XQ
authors.lastname: Shen
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, Beijing, China. 301chenyundai@sina.com.
authors.forename: Yun-Dai
authors.initials: YD
authors.lastname: Chen
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, Beijing, China.
authors.forename: Shun-Ying
authors.initials: SY
authors.lastname: Hu
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, Beijing, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Qian
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, Beijing, China.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Yang
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, Beijing, China.
authors.forename: Zhi-Feng
authors.initials: ZF
authors.lastname: Wang
authors.affiliation: Department of Cardiology, PLA General Hospital at Beijing, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Tian
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D004311:Double-Blind Method; D004452:Echocardiography; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D000069450:Liraglutide / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000072658:Non-ST Elevated Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D018384:Oxidative Stress / Q000187:drug effects; D010919:Placebos; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
chemical_list: D008055:Lipids; D010919:Placebos; D000069450:Liraglutide; D002097:C-Reactive Protein
keywords: Congestive heart failure; Glucagon-like peptide-1; Left ventricular ejection fraction; Metabolism; Non-ST-segment elevation myocardial infarction