title: Deciphering Depressive Mood in Relapsing-Remitting and Progressive Multiple Sclerosis and Its Consequence on Quality of Life.
abstract: BACKGROUND
  Depressive mood and other emotional symptoms are common in multiple sclerosis (MS). The patient-reported outcome version of the "Echelle d'Humeur Dépressive" (EHD-PRO) aims to differentiate between two dimensions of depressive mood in people living with MS (PwMS).
  
  
  OBJECTIVE
  First, to compare EHD-PRO assessment and its two dimensions, lack of emotional control and emotional blunting, between a large sample of healthy controls (HCs) and two samples of PwMS, relapsing-remitting MS (RRMS) and primary progressive MS (PPMS); and second, to analyse the relationships between EHD-PRO scores with neurological disability, cognitive function, fatigue and health-related quality of life (HR-QOL).
  
  
  RESULTS
  Regardless of their phenotype, PwMS had significantly higher EHD-PRO scores than HCs. EHD-PRO scores did not differ between the two MS groups. EHD-PRO scores did not correlate with disability and fatigue scores, disease duration or cognitive z scores. In RRMS, the lack of emotional control was independently associated with a decrease in HR-QOL.
  
  
  CONCLUSIONS
  The EHD-PRO is able to easily detect depressive mood and to differentiate between two clinical dimensions, emotional blunting and lack of emotional control. The scale is sensitive and seems robust to confounding factors. Lack of emotional control seems to contribute significantly to altered HR-QOL in RRMS.
authors.affiliation: INSERM U.862, Neurocentre Magendie, Université de Bordeaux, Bordeaux, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Lamargue Hamel
authors.affiliation: INSERM-CHU CIC-P 0005, & Service de Neurologie, CHU de Bordeaux, F-33076, Bordeaux, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Deloire
authors.affiliation: INSERM U.862, Neurocentre Magendie, Université de Bordeaux, Bordeaux, France.|INSERM-CHU CIC-P 0005, & Service de Neurologie, CHU de Bordeaux, F-33076, Bordeaux, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Ruet
authors.affiliation: INSERM-CHU CIC-P 0005, & Service de Neurologie, CHU de Bordeaux, F-33076, Bordeaux, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Charré-Morin
authors.affiliation: INSERM-CHU CIC-P 0005, & Service de Neurologie, CHU de Bordeaux, F-33076, Bordeaux, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Saubusse
authors.affiliation: INSERM-CHU CIC-P 0005, & Service de Neurologie, CHU de Bordeaux, F-33076, Bordeaux, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Ouallet
authors.affiliation: INSERM U.862, Neurocentre Magendie, Université de Bordeaux, Bordeaux, France.|INSERM-CHU CIC-P 0005, & Service de Neurologie, CHU de Bordeaux, F-33076, Bordeaux, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Brochet
mesh_terms: D000328:Adult; D003863:Depression / Q000150:complications / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000523:psychology*; D011788:Quality of Life