title: Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals.
abstract: Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.
authors.affiliation: Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. ksalado@hotmail.com.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Salado-Rasmussen
authors.forename: Steen
authors.initials: S
authors.lastname: Hoffmann
authors.forename: Susan
authors.initials: S
authors.lastname: Cowan
authors.forename: Jørgen Skov
authors.initials: JS
authors.lastname: Jensen
authors.forename: Thomas
authors.initials: T
authors.lastname: Benfield
authors.forename: Jan
authors.initials: J
authors.lastname: Gerstoft
authors.forename: Terese Lea
authors.initials: TL
authors.lastname: Katzenstein
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003718:Denmark; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006679:HIV Seropositivity; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D013587:Syphilis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D004318:Doxycycline