title: Ceruloplasmin and antioxidative enzymes in pre-eclampsia.
abstract: OBJECTIVE
  To evaluate diagnostic value of ceruloplasmin together with other enzymatic and nonenzymatic antioxidants (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and uric acid) and to evaluate the level of oxidative stress in patients with pre-eclampsia (PE) and compare it with normal pregnancy.
  
  
  METHODS
  In this prospective study, antioxidative markers were investigated in two groups of pregnant women: patients with pre-eclampsia (n = 32) and the healthy pregnant women (n = 60). The following antioxidative markers and enzymes were evaluated: serum ceruloplasmin levels, uric acid, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px).
  
  
  RESULTS
  Serum levels of ceruloplasmin, uric acid and SOD were significantly higher in the PE group compared to the control group. Serum levels of GSH-Px were not significantly higher in the PE group compared to the control group. Serum ceruloplasmin and serum uric acid have the best diagnostic accuracy for oxidative stress in PE and are more accurate compared to antioxidative enzymes -SOD and specially more accurate than GSH-Px.
  
  
  CONCLUSIONS
  Serum ceruloplasmin level may have significant role as the markers of oxidative stress in pre-eclampsia especially when used in combination with uric acid levels.
authors.affiliation: a Department of Pharmacy , University of Novi Sad , Novi Sad , Serbia .
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Nikolic
authors.affiliation: b Department of Laboratory Medicine , Clinical Centre of Vojvodina, University of Novi Sad , Novi Sad , Serbia , and.
authors.forename: Velibor
authors.initials: V
authors.lastname: Cabarkapa
authors.affiliation: c Department of Obstetrics and Gynaecology , Clinical Centre of Vojvodina , Novi Sad , Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Novakov Mikic
authors.affiliation: b Department of Laboratory Medicine , Clinical Centre of Vojvodina, University of Novi Sad , Novi Sad , Serbia , and.
authors.forename: Ana
authors.initials: A
authors.lastname: Jakovljević
authors.affiliation: b Department of Laboratory Medicine , Clinical Centre of Vojvodina, University of Novi Sad , Novi Sad , Serbia , and.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Stosic
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000032:analysis*; D016009:Chi-Square Distribution; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin
keywords: Ceruloplasmin; GSH-Px; SOD; oxidative stress; pre-eclampsia; uric acid