title: Improvement of antimicrobial activity of graphene oxide/bacterial cellulose nanocomposites through the electrostatic modification.
abstract: Graphene oxide (GO) has an attracting and ever-growing interest in various research fields for its fascinating nanostructures. In this study, bacterial cellulose (BC) was used as a matrix to synthesize GO-based materials by a mechanical mixing method. The modification of GO with PEI significantly improved the bonding force between GO nanofillers and BC matrix. The morphology of the nanocomposites had a significant effect on the mechanical properties, hydrophilic properties as well as the antibacterial activity. After the modification, the GO-PEI/BC showed a strong antimicrobial effect on Saccharomyces cerevisiae due to the effective direct contacts between the nanofillers of the composites and the cell surfaces. This study demonstrates that the morphology of the nanocomposites has a great effect on physiochemical properties and the interactions between the microorganism and the nanocomposites.
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, PR China.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Yang
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, PR China.
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Xue
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, PR China.
authors.forename: Jia-Ying
authors.initials: JY
authors.lastname: Li
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, PR China.
authors.forename: Miao
authors.initials: M
authors.lastname: Liu
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, PR China.
authors.forename: Shi-Ru
authors.initials: SR
authors.lastname: Jia
authors.affiliation: School of Chemical Engineering and Material Science, Tianjin University of Science & Technology, Tianjin 300457, PR China.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Chu
authors.affiliation: School of Chemical Engineering and Material Science, Tianjin University of Science & Technology, Tianjin 300457, PR China.
authors.forename: Fazli
authors.initials: F
authors.lastname: Wahid
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, PR China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, PR China; Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin 300072, PR China. Electronic address: czhong@tust.edu.cn.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhong
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D002482:Cellulose / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004355:Drug Stability; D041822:Gluconacetobacter xylinus / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D055595:Mechanical Phenomena; D050296:Microbial Viability / Q000187:drug effects; D053761:Nanocomposites / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D013211:Staphylococcus aureus / Q000187:drug effects; D055672:Static Electricity
chemical_list: D000890:Anti-Infective Agents; D010087:Oxides; D006108:Graphite; D011094:Polyethyleneimine; D002482:Cellulose
keywords: Antimicrobial activity; Bacterial cellulose; Charge modification; Direct contact; Electrostatic interactions; Graphene oxide