title: [Effect of L-carnitine, afobazole and their combination with L-arginine on biochemical and histological indices of endothelial disfunction in cobalt intoxication in rats].
abstract: The influence of L-carnitine and afobazole and their combination with L-arginine on biochemical and histological indices of endothelial dysfunction in rats with cobalt intoxication. The obtained data revealed biochemical markers of endothelial dysfunction. Found that-in rats with cobalt intoxication during treatment occurred inhibition of lipid peroxidation (LPO), reduced the concentration of malondialdehyde (MDA) in erythrocytes, activation of superoxide dismutase (SOD). This was accompanied by increased concentrations of nitric oxide (NO), the availability of the substrate L-arginine and possibly the expression of eNOS in the background of L-carnitine and afobazole.
authors.forename: S G
authors.initials: SG
authors.lastname: Dzugkoev
authors.forename: I V
authors.initials: IV
authors.lastname: Mozhaeva
authors.forename: M A
authors.initials: MA
authors.lastname: Otiev
authors.forename: O I
authors.initials: OI
authors.lastname: Margieva
authors.forename: F S
authors.initials: FS
authors.lastname: Dzugkoeva
mesh_terms: D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002331:Carnitine / Q000494:pharmacology*; D003035:Cobalt / Q000506:poisoning*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D000075322:Heavy Metal Poisoning; D008297:Male; D019216:Metals, Heavy / Q000378:metabolism; D009025:Morpholines / Q000494:pharmacology*; D011041:Poisoning / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D019216:Metals, Heavy; D009025:Morpholines; D003035:Cobalt; D001120:Arginine; D002331:Carnitine