title: A 'turn-on' fluorescent chemosensor for quantification of serum albumin in aqueous solution at neutral pH.
abstract: A fluorescent chemosensor 1 (4-diethylamino-2'-hydroxychalcone) for detecting serum albumin with long-wavelength emission, good selectivity and facile synthesis was reported. Upon the addition of bovine serum albumin (BSA) to an aqueous solution of 1 at neutral pH, a 'turn-on' fluorescence response was observed at 596 nm based on a hydrophobic binding mode between 1 and BSA. A linear range of 0.10-1.00 mg/mL and a detection limit of 9.1 µg/mL for BSA were obtained, respectively. Moreover, 1 was successfully applied to detect BSA in real bovine serum samples with satisfied recovery and accuracy, which suggested that 1 could serve as a valid and effective fluorescent chemosensor for quantification of BSA.
authors.affiliation: School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: He
mesh_terms: D000818:Animals; D002417:Cattle; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D012710:Serum Albumin, Bovine / Q000032:analysis* / Q000737:chemistry; D012996:Solutions; D014867:Water / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D012996:Solutions; D014867:Water; D012710:Serum Albumin, Bovine
keywords: chemosensor; fluorescence turn-on; long-wavelength emission; serum albumin