title: NIR-Laser-Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors.
abstract: In vivo MEO2 MA@MEO2 MA-co-OEGMA-CuS-DOX (G-CuS-DOX) nanocapsules increase the temperature of tumors from room temperature to 57 °C due to the photothermal effect under irradiation from a 915-nm laser. When the temperature exceeds 42 °C, photothermal therapy of G-CuS-DOX is switched on. Simultaneously, higher temperatures (>LCST, 42 °C) induce volume shrinkage of G-CuS-DOX in vivo, leading to the controllable release of the anticancer drug DOX. If the NIR laser is switched off, both therapy effects are interrupted immediately.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.
authors.forename: Zhouqi
authors.initials: Z
authors.lastname: Meng
authors.affiliation: Experimental Research Center, The First People's Hospital, Shanghai Jiaotong University, Shanghai, 201620, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wei
authors.affiliation: Experimental Research Center, The First People's Hospital, Shanghai Jiaotong University, Shanghai, 201620, China.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.
authors.forename: Mengge
authors.initials: M
authors.lastname: Xia
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Experimental Research Center, The First People's Hospital, Shanghai Jiaotong University, Shanghai, 201620, China.
authors.forename: Huiping
authors.initials: H
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.
authors.forename: Meifang
authors.initials: M
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D006979:Hyperthermia, Induced; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D028022:Low-Level Light Therapy / Q000379:methods*; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry; D009368:Neoplasm Transplantation; D047368:Tumor Burden / Q000187:drug effects / Q000528:radiation effects; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D053769:Nanocapsules; D014867:Water; D004317:Doxorubicin
keywords: NIR lasers; chemotherapy; photothermal therapy; smart nanocapsules; switches; tumors