title: Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
abstract: OBJECTIVE
  Recent studies have demonstrated that the neural precursor cell expressed, developmentally downregulated 4-like (Nedd4L) gene plays a role in the progression of various cancers. However, reports describing Nedd4L expression in ovarian cancer tissues are limited.
  
  
  METHODS
  A cohort (n = 117) of archival formalin-fixed, paraffin embedded resected normal ovarian epithelial tissues (n = 10), benign ovarian epithelial tumor tissues (n = 10), serous borderline ovarian epithelial tumor tissues (n = 14), mucous borderline ovarian epithelial tumor tissues (n = 11), and invasive ovarian epithelial cancer tissues (n = 72) were assessed for Nedd4L protein expression using immunohistochemistry.
  
  
  RESULTS
  Nedd4L protein expression was significantly decreased in invasive ovarian epithelial cancer tissues compared to non-cancer tissues (P < 0.05). Decreased Nedd4L protein expression correlated with clinical stage, pathological grade, lymph node metastasis and survival (P < 0.05).
  
  
  CONCLUSIONS
  Nedd4L protein expression may be an independent prognostic marker of ovarian cancer development.
authors.affiliation: Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin Province, China.|Department of Gynaecology and Obstetrics, The Hospital of Binzhou Medical University Campus, Yantai, Shandong Province, China.
authors.forename: Qiuyun
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, The Hospital of Binzhou Medical University Campus, Yantai, Shandong Province, China.
authors.forename: Jinghe
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Manhua
authors.initials: M
authors.lastname: Cui
authors.affiliation: Department of Inspection, Harbin Medical University Daqing Campus, Daqing, Heilongjiang Province, China.
authors.forename: Shuting
authors.initials: S
authors.lastname: Gi
authors.affiliation: Department of Gynaecology and Obstetrics, The Hospital of Binzhou Medical University Campus, Yantai, Shandong Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: Xiaole
authors.initials: X
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D000077216:Carcinoma, Ovarian Epithelial; D056827:Endosomal Sorting Complexes Required for Transport / Q000032:analysis* / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D000075702:Nedd4 Ubiquitin Protein Ligases; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D010053:Ovary / Q000737:chemistry*; D011379:Prognosis; D044767:Ubiquitin-Protein Ligases / Q000032:analysis* / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; D056827:Endosomal Sorting Complexes Required for Transport; D000075702:Nedd4 Ubiquitin Protein Ligases; C000618485:Nedd4L protein, human; D044767:Ubiquitin-Protein Ligases
keywords: NeddL4; immunohistochemistry; neural precursor cell expressed; ovarian cancer; prognosis