title: Deficiency of respiratory chain complex I in Hashimoto thyroiditis.
abstract: Oncocytic cells (OCs) are characterized by an accumulation of mitochondria and their occurrence in the thyroid gland of patients with Hashimoto thyroiditis (HT) is well known. However, their properties and functional relevance are poorly understood. We investigated OC lesions (n=212) in the thyroid of 12 HT patients. Loss of complex I protein was observed in oncocytic lesions of each of the patients. In addition to isolated complex I deficiency, 25% of oncocytic lesions showed combined deficiency of complex I and IV. Thus, we demonstrate for the first time a defect of respiratory chain complex I in OCs of HT patients.
authors.affiliation: Department of Pediatrics, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria; Research Program for Receptor Biochemistry and Tumor Metabolism, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria. Electronic address: f.zimmermann@salk.at.
authors.forename: Franz A
authors.initials: FA
authors.lastname: Zimmermann
authors.affiliation: Department of Pathology, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria. Electronic address: d.neureiter@salk.at.
authors.forename: Daniel
authors.initials: D
authors.lastname: Neureiter
authors.affiliation: Department of Pediatrics, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria; Research Program for Receptor Biochemistry and Tumor Metabolism, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria. Electronic address: r.feichtinger@salk.at.
authors.forename: René G
authors.initials: RG
authors.lastname: Feichtinger
authors.affiliation: University Clinic of Ophthalmology and Optometry, Research Program for Ophthalmology and Glaucoma Research, Paracelsus Medical University/SALK, A-5020 Salzburg, Austria. Electronic address: a.zurl@salk.at.
authors.forename: Andrea
authors.initials: A
authors.lastname: Trost
authors.affiliation: Department of Pediatrics, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria. Electronic address: w.sperl@salk.at.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sperl
authors.affiliation: Department of Pediatrics, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria; Research Program for Receptor Biochemistry and Tumor Metabolism, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria. Electronic address: b.kofler@salk.at.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kofler
authors.affiliation: Department of Pediatrics, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria. Electronic address: h.mayr@salk.at.
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Mayr
mesh_terms: D000328:Adult; D000368:Aged; D042967:Electron Transport Complex I / Q000172:deficiency*; D005260:Female; D050031:Hashimoto Disease / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D008928:Mitochondria / Q000201:enzymology* / Q000473:pathology; D013961:Thyroid Gland / Q000201:enzymology* / Q000473:pathology
chemical_list: D042967:Electron Transport Complex I
keywords: Autoimmune disease; Hashimoto thyroiditis; Mitochondria; Oncocytic cell; Respiratory chain complex I