title: Seven-Year Clinical Outcomes of Successful Versus Failed Revascularization Using Drug-Eluting Stents for the Treatment of Coronary Chronic Total Occlusion.
abstract: OBJECTIVE
  The aim of our study is to investigate the long-term, 7-year clinical outcomes of patients who received successful or failed revascularization using a drug-eluting stent (DES) for the treatment of chronic total occlusion (CTO).
  
  
  BACKGROUND
  The benefits of successful CTO revascularization remain unclear.
  
  
  METHODS
  In this prospective cohort study, a total of 377 consecutive CTO patients were divided according to successful (n = 253) or failed (n = 124) DES revascularization. We compared a composite index that consisted of death, myocardial infarction (MI), stroke, and target-vessel revascularization (TVR) at 7 years using propensity matching and inverse probability of treatment weighted (IPTW) analyses.
  
  
  RESULTS
  After a median follow-up period of 2561 days (interquartile range, 1533-2996 days), the successful-revascularization group demonstrated numerically lower incidence of the composite endpoint than the failed-revascularization group (26.5% vs 34.3%, respectively; log-rank P=.27). After IPTW adjustment, the risk of clinical outcomes (hazard ratio, 1.00; 95% confidence interval, 0.58-1.74; P=.99) was not statistically different between the groups. Propensity-score matching analysis (91 matched pairs) revealed similar outcomes (hazard ratio, 1.09; 95% confidence interval, 0.62-1.90; P=.77).
  
  
  CONCLUSIONS
  Successful CTO revascularization does not demonstrate beneficial long-term clinical outcomes over 7 years compared with failed revascularization.
authors.forename: Jong-Pil
authors.initials: JP
authors.lastname: Park
authors.forename: Seungbong
authors.initials: S
authors.lastname: Han
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Sung
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. jyleeheart.lee@samsung.com.
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Hyo-In
authors.initials: HI
authors.lastname: Choi
mesh_terms: D000368:Aged; D002908:Chronic Disease; D015331:Cohort Studies; D054059:Coronary Occlusion / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D000069451:Long Term Adverse Effects / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D016016:Proportional Hazards Models; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D013997:Time Factors