title: The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis.
abstract: BACKGROUND
  The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive.
  
  
  METHODS
  We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. Data was extracted by a standard algorithm. Dominant, recessive, homozygote, and heterozygote comparison models were utilized.
  
  
  RESULTS
  24 studies incorporating 52,785 subjects were included in this meta-analysis. Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = -0.04, 95% CI (-0.08, 0.00), P = 0.048, P heterogeneity = 0.47; recessive model: SMD = -0.10, 95% CI (-0.18, -0.02), P = 0.01, P heterogeneity = 0.56). No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects.
  
  
  CONCLUSIONS
  Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes. No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.
authors.affiliation: The Geriatric Cardiology Department, Chinese PLA General Hospital, Beijing 100853, China ; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
authors.forename: Shuxia
authors.initials: S
authors.lastname: Wang
authors.affiliation: The Geriatric Cardiology Department, Chinese PLA General Hospital, Beijing 100853, China ; Department of Cardiology, Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing 100853, China.
authors.forename: Kangxing
authors.initials: K
authors.lastname: Song
authors.affiliation: Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
authors.forename: Roshni
authors.initials: R
authors.lastname: Srivastava
authors.affiliation: Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Fathzadeh
authors.affiliation: Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA ; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Arya
authors.initials: A
authors.lastname: Mani
mesh_terms: D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005215:Fasting / Q000097:blood; D020022:Genetic Predisposition to Disease; D006801:Humans; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*; D014280:Triglycerides / Q000097:blood*
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D014280:Triglycerides