title: Ineffective VTA Disinhibition in Protracted Opiate Withdrawal.
abstract: Recently, Kaufling and Aston-Jones showed that, under protracted opiate withdrawal, control of dopamine activity by the tail of the ventral tegmental area shifts from a bidirectional influence towards one-way inhibition. Beyond dysphoric states accompanying withdrawal, these results may also impact research on depression and individual differences in coping and affect.
authors.affiliation: Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, 5 rue Blaise Pascal, 67084 Strasbourg, France; Université de Strasbourg, Strasbourg, France. Electronic address: mbarrot@inci-cnrs.unistra.fr.
authors.forename: Michel
authors.initials: M
authors.lastname: Barrot
mesh_terms: D000818:Animals; D059290:Dopaminergic Neurons / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009294:Narcotics / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000473:pathology*; D017557:Ventral Tegmental Area / Q000473:pathology*
chemical_list: D009294:Narcotics; D009020:Morphine
keywords: Depression; Dopamine; Morphine; RMTg; Withdrawal; tVTA