title: Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib.
authors.forename: Victor
authors.initials: V
authors.lastname: Wong
authors.forename: Dean
authors.initials: D
authors.lastname: Pavlick
authors.forename: Tim
authors.initials: T
authors.lastname: Brennan
authors.forename: Roman
authors.initials: R
authors.lastname: Yelensky
authors.forename: John
authors.initials: J
authors.lastname: Crawford
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Ross
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Miller
authors.forename: Denise
authors.initials: D
authors.lastname: Malicki
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Stephens
authors.affiliation: Rady Childrens Hospital, San Diego, CA (VW, JC, DM, HA); Foundation Medicine, Inc., Cambridge, MA (DP, TB, RY, JSR, VAM, PJS, SMA); Albany Medical College, Albany, NY (JSR). siraj@foundationmedicine.com.
authors.forename: Siraj M
authors.initials: SM
authors.lastname: Ali
authors.forename: Hyunah
authors.initials: H
authors.lastname: Ahn
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000077547:Crizotinib; D005354:Fibrosarcoma / Q000151:congenital / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D050939:Gene Fusion; D006801:Humans; D007223:Infant; D034904:Lamin Type A / Q000235:genetics*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D058990:Molecular Targeted Therapy; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D020917:Receptor, trkA / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013125:Spinal Neoplasms / Q000188:drug therapy / Q000556:secondary; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; C494847:LMNA protein, human; D034904:Lamin Type A; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; D020917:Receptor, trkA