title: Cell Competition: Roles and Importance as a Central Phenomenon.
abstract: Cell competition is a type of short-range cell-cell interaction first observed in Drosophila melanogaster. In two heterogeneous cell populations, cells that have a higher fitness level would have a competitive advantage and grow at the cost of neighbor cells that have comparatively lower fitness. This interaction is due to differences in expression levels of a specific protein in the two cell populations, and it is known as cell competition. In this review, we have studied recent findings of cell competition in different biological processes in Drosophila as well as mammalian systems. The purpose of this review is to collate important studies of competitive cell interactions, and to understand its roles and importance as a central phenomenon. This review provides evidence of the relevance of cell competition in various physiological and pathological conditions, such as size control in organ development, stem cell maintenance, tissue repair, organ regeneration, aging, formation of memory, and cancer.
authors.affiliation: Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Ahmedabad-380054, Gujarat, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Patel
authors.affiliation: Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Ahmedabad-380054, Gujarat, India.
authors.forename: Bhavesh
authors.initials: B
authors.lastname: Antala
authors.affiliation: Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Ahmedabad-380054, Gujarat, India; Department of Pharmacognosy and Phytochemistry, B. V. Patel Pharmaceutical Education and Research Development.
authors.forename: Neeta
authors.initials: N
authors.lastname: Shrivastava
mesh_terms: D000818:Animals; D002450:Cell Communication; D002468:Cell Physiological Phenomena; D004330:Drosophila / Q000166:cytology / Q000254:growth & development; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D014945:Wound Healing