title: Customizable 3D Printed 'Plug and Play' Millifluidic Devices for Programmable Fluidics.
abstract: Three dimensional (3D) printing is actively sought after in recent years as a promising novel technology to construct complex objects, which scope spans from nano- to over millimeter scale. Previously we utilized Fused deposition modeling (FDM)-based 3D printer to construct complex 3D chemical fluidic systems, and here we demonstrate the construction of 3D milli-fluidic structures for programmable liquid handling and control of biological samples. Basic fluidic operation devices, such as water-in-oil (W/O) droplet generators for producing compartmentalized mono-disperse droplets, sensor-integrated chamber for online monitoring of cellular growth, are presented. In addition, chemical surface treatment techniques are used to construct valve-based flow selector for liquid flow control and inter-connectable modular devices for networking fluidic parts. As such this work paves the way for complex operations, such as mixing, flow control, and monitoring of reaction / cell culture progress can be carried out by constructing both passive and active components in 3D printed structures, which designs can be shared online so that anyone with 3D printers can reproduce them by themselves.
authors.affiliation: WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom.|Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Tsuda
authors.affiliation: WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Hussain
authors.initials: H
authors.lastname: Jaffery
authors.affiliation: WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Doran
authors.affiliation: WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hezwani
authors.affiliation: WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Robbins
authors.affiliation: WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Mari
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: WestCHEM, School of Chemistry, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Leroy
authors.initials: L
authors.lastname: Cronin
mesh_terms: D001419:Bacteria / Q000302:isolation & purification; D056656:Lab-On-A-Chip Devices; D066330:Printing, Three-Dimensional