title: Palladium-Catalyzed Synthesis of Δ(2)-Isoxazoline from Toluene Derivatives Enabled by the Triple Role of Silver Nitrate.
abstract: A palladium-catalyzed direct synthesis of Δ(2)-isoxazoline from toluene derivatives has been established. The present reaction proceeds through nondirected Csp(3)-H activation, benzylic nitration, dehydration, and cycloaddition. This protocol also features the unusual triple role of silver nitrate in a one-pot reaction.
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, Shanghai University , 99 Shangda Road, Shanghai 200444, P. R. China.|College of Environmental and Chemical Engineering, Shanghai University , Shanghai 200444, P. R. China.
authors.forename: Chengliang
authors.initials: C
authors.lastname: Li
authors.affiliation: Laboratory for Microstructures, Shanghai University , Shanghai, 200444, P. R. China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, Shanghai University , 99 Shangda Road, Shanghai 200444, P. R. China.
authors.forename: Chunju
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, Shanghai University , 99 Shangda Road, Shanghai 200444, P. R. China.
authors.forename: Xueshun
authors.initials: X
authors.lastname: Jia
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, Shanghai University , 99 Shangda Road, Shanghai 200444, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li