title: miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer.
abstract: Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian cancer tissues and cell lines. miR‑382 inhibited ovarian cancer cell proliferation, migration, invasion and the epithelial-mesenchymal transition (EMT). Furthermore, we identified receptor tyrosine kinase orphan receptor 1 (ROR1) as a target of miR‑382, and miR‑382 rescued the promotion effect of ROR1 on migration, invasion and EMT process in SKOV3 and COV434 cells. Collectively, these findings revealed that miR‑382 inhibits migration and invision by targeting ROR1 through regulating EMT in ovarian cancer, and might serve as a tumor suppressor in ovarian cancer.
authors.affiliation: Department of Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Tan
authors.affiliation: Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Qingnan
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Guanhui
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Juanni
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Junpu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Ding
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Department of Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wu
mesh_terms: D063646:Carcinogenesis / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000096:biosynthesis / Q000235:genetics*
chemical_list: C555413:MIRN382 microRNA, human; D035683:MicroRNAs; C078716:ROR1 protein, human; D057050:Receptor Tyrosine Kinase-like Orphan Receptors