title: Analysis on correlation of white matter lesion and lacunar infarction with vascular cognitive impairment.
abstract: OBJECTIVE
  To investigate the correlation of white matter lesion (WML) and lacunar infarction (LI) with vascular cognitive impairment. To investigate the correlation of cognitive changes of vascular dementia (VD) patients with lacunar infarction (LI) and white matter lesion (WML).
  
  
  METHODS
  The clinical data of 60 cases of VD patients were evaluated and analyzed by combining with imageological findings and cognitive function assessment.
  
  
  RESULTS
  Multiple LI and WML were negatively correlated with both mini-mental state examination (MMSE) scale scores (r = -0.401, P = 0.036) and clock drawing test (CDT) scale scores (r = -0.482, P = 0.028); the LI number in occipital lobe was negatively correlated with MMSE scores (r = 0.338, P = 0.048), the LI number in temporal lobe was negatively correlated with CDT scores (r = -0.235, P = 0.047), and the LI number in frontal lobe was negatively correlated with MoCA scores (r = -0.450, P = 0.039).
  
  
  CONCLUSIONS
  All of LI location and number as well as WML are independent influencing factors of cognitive impairment of VD patients.
authors.affiliation: Department of Imaging, The Third Hospital of Ji Nan Shandong, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yan
authors.affiliation: Department of Imaging, The Third Hospital of Ji Nan Shandong, China.
authors.forename: Jia-Rui
authors.initials: JR
authors.lastname: Yu
authors.affiliation: Department of Imaging, The Third Hospital of Ji Nan Shandong, China.
authors.forename: Yun-Pei
authors.initials: YP
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The Fourth Hospital of Ji Nan Shandong, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
keywords: White matter lesion; multiple lacunar infarction; vascular cognitive impairment