title: Cannabidiol-2',6'-dimethyl ether stimulates body weight gain in apolipoprotein E-deficient BALB/c. KOR/Stm Slc-Apoe(shl) mice.
abstract: The biological activities of cannabidiol (CBD), a major non-psychotropic constituent of the fiber-type cannabis plant, have been examined in detail (e.g., CBD modulation of body weight in mice and rats). However, few studies have investigated the biological activities of cannabidiol-2',6'-dimethyl ether (CBDD), a dimethyl ether derivative of the parent CBD. We herein focused on the effects of CBDD on body weight changes in mice, and demonstrated that it stimulated body weight gain in apolipoprotein E (ApoE)-deficient BALB/c. KOR/Stm Slc-Apoe(shl) mice, especially between 10 and 20 weeks of age.
authors.affiliation: Department of Molecular Biology, Daiichi University of Pharmacy.
authors.forename: Shuso
authors.initials: S
authors.lastname: Takeda
authors.forename: Rena
authors.initials: R
authors.lastname: Hirota
authors.forename: Sari
authors.initials: S
authors.lastname: Teradaira
authors.forename: Masumi
authors.initials: M
authors.lastname: Takeda-Imoto
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Watanabe
authors.forename: Akihisa
authors.initials: A
authors.lastname: Toda
authors.forename: Hironori
authors.initials: H
authors.lastname: Aramaki
mesh_terms: D000367:Age Factors; D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency*; D002185:Cannabidiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D013268:Stimulation, Chemical; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D001057:Apolipoproteins E; C065844:cannabidiol dimethyl ether; D002185:Cannabidiol