title: Curcumin promotes nerve regeneration and functional recovery after sciatic nerve crush injury in diabetic rats.
abstract: Curcumin is capable of promoting peripheral nerve regeneration in normal condition. However, it is unclear whether its beneficial effect on nerve regeneration still exists under diabetic mellitus. The present study was designed to investigate such a possibility. Diabetes in rats was developed by a single dose of streptozotocin at 50 mg/kg. Immediately after nerve crush injury, the diabetic rats were intraperitoneally administrated daily for 4 weeks with curcumin (50 mg/kg, 100 mg/kg and 300 mg/kg), or normal saline, respectively. The axonal regeneration was investigated by morphometric analysis and retrograde labeling. The functional recovery was evaluated by electrophysiological studies and behavioral analysis. Axonal regeneration and functional recovery was significantly enhanced by curcumin, which were significantly better than those in vehicle saline group. In addition, high doses of curcumin (100 mg/kg and 300 mg/kg) achieved better axonal regeneration and functional recovery than low dose (50 mg/kg). In conclusion, curcumin is capable of promoting nerve regeneration after sciatic nerve crush injury in diabetes mellitus, highlighting its therapeutic values as a neuroprotective agent for peripheral nerve injury repair in diabetes mellitus.
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Rescue Center of Severe Wound Chinese Trauma of PLA, Shenyang 110016, Liaoning, China.
authors.forename: Junxiong
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Rescue Center of Severe Wound Chinese Trauma of PLA, Shenyang 110016, Liaoning, China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Rescue Center of Severe Wound Chinese Trauma of PLA, Shenyang 110016, Liaoning, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Rescue Center of Severe Wound Chinese Trauma of PLA, Shenyang 110016, Liaoning, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Rescue Center of Severe Wound Chinese Trauma of PLA, Shenyang 110016, Liaoning, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Rescue Center of Severe Wound Chinese Trauma of PLA, Shenyang 110016, Liaoning, China. Electronic address: xiangliangbi1963@sina.com.
authors.forename: Liangbi
authors.initials: L
authors.lastname: Xiang
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology; D003474:Curcumin / Q000494:pharmacology / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology*; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D059348:Peripheral Nerve Injuries / Q000150:complications / Q000503:physiopathology*; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries*
chemical_list: D018696:Neuroprotective Agents; D003474:Curcumin
keywords: Axonal regeneration; Curcumin; Functional recovery; Neuroprotective; Sciatic nerve injury