title: Yb³⁺/Er³⁺-Codoped Bi₂O₃ Nanospheres: Probe for Upconversion Luminescence Imaging and Binary Contrast Agent for Computed Tomography Imaging.
abstract: In this work, water-soluble Yb(3+)/Er(3+) codoped Bi2O3 upconversion (UC) nanospheres with uniform morphology have been successfully synthesized via a solid-state-chemistry thermal decomposition process. With 980 nm near-infrared irradiation, the Bi2O3:Yb(3+)/Er(3+) nanospheres have bright UC luminescence (UCL). Moreover, multicolor UC emissions (from green to red) can be tuned by simply changing the Yb(3+) ions doping concentration. After citric acid molecules were grafted on the surface of Bi2O3:20% Yb(3+)/2% Er(3+) nanospheres, the MTT assay on HeLa cells and CCK-8 assay on osteoblasts show that the UC nanospheres exhibit excellent stability and biocompatibility. The possibility of using these nanoprobes with red UCL for optical imaging in vivo has been demonstrated. Furthermore, Bi(3+) and Yb(3+) containing nanospheres as binary contrast agent also exhibited significant enhancement of contrast efficacy than iodine-based contrast agent via X-ray computed tomography (CT) imaging at different voltage setting (80-140 kVp), indicating they have potential as CT imaging contrast agent. Thus, Yb(3+)/Er(3+) codoped Bi2O3 nanospheres could be used as dual modality probe for optical and CT imagings.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun 130022, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Pengpeng
authors.initials: P
authors.lastname: Lei
authors.affiliation: Department of Radiology, The Second Hospital of Jilin University , Changchun 130041, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The Second Hospital of Jilin University , Changchun 130041, China.
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun 130022, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun 130022, China.|University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Lile
authors.initials: L
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun 130022, China.
authors.forename: Shuyan
authors.initials: S
authors.lastname: Song
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun 130022, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun 130022, China.
authors.forename: Xiuling
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun 130022, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun 130022, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001729:Bismuth / Q000737:chemistry*; D016923:Cell Death; D002470:Cell Survival; D003287:Contrast Media / Q000737:chemistry*; D004735:Energy Transfer; D004871:Erbium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015552:Injections, Intralesional; D049449:Luminescence; D051379:Mice; D054118:Nanospheres / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014961:X-Ray Diffraction; D015018:Ytterbium / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D004871:Erbium; C033301:bismuth oxide; D015018:Ytterbium; D001729:Bismuth
keywords: Bi2O3; binary contrast agent; dual-modal imaging; lanthanide; upconversion luminescence