title: Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma: Long-term results.
abstract: Grade ≥2 acute xerostomia between 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) was evaluated in patients with head and neck squamous cell carcinomas (HNSCCs) treated radically.
  
  
  
  Between 2005 and 2007, 59 patients with HNSCC (T1-3, N0-2b) were randomized to IMRT or 3D-RT. On RT, weekly xerostomia, dysphagia, dermatitis, and mucositis were graded by Radiation Therapy Oncology Group (RTOG) acute toxicity criteria. Patients underwent examination under anesthesia, positron emission tomography (PET)-CT, and toxicity assessments per protocol (NCT00652613) thereafter.
  
  
  
  Incidence of grade ≥2 xerostomia at 8 weeks posttreatment was significantly lower with IMRT compared with 3D conformal RT (24% vs 53%; p = .024). At subsequent follow-up, significantly fewer patients receiving IMRT had grade ≥2 xerostomia. Long-term weight loss was higher in patients in the 3D conformal RT arm compared to IMRT (50% vs 21%; p = .038). Disease-related outcomes between arms (median follow-up, 70 months) were similar.
  
  
  
  IMRT significantly reduces incidence of acute and late grade ≥2 xerostomia in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1481-E1487, 2016.
authors.affiliation: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: Sarbani
authors.initials: S
authors.lastname: Ghosh-Laskar
authors.affiliation: Department of Radiation Oncology, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Prahlad H
authors.initials: PH
authors.lastname: Yathiraj
authors.affiliation: Department of Radiation Oncology, Apollo Speciality Cancer Hospital, Chennai, Tamil Nadu, India.
authors.forename: Debnarayana
authors.initials: D
authors.lastname: Dutta
authors.affiliation: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Rangarajan
authors.affiliation: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: Nilendu
authors.initials: N
authors.lastname: Purandare
authors.affiliation: Department of Radiation Oncology, Advanced Center for Treatment, Research, and Education in Cancer (ACTREC), Navi Mumbai, Maharashtra, India.
authors.forename: Tejpal
authors.initials: T
authors.lastname: Gupta
authors.affiliation: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: Ashwini
authors.initials: A
authors.lastname: Budrukkar
authors.affiliation: Department of Radiation Oncology, Advanced Center for Treatment, Research, and Education in Cancer (ACTREC), Navi Mumbai, Maharashtra, India.
authors.forename: Vedang
authors.initials: V
authors.lastname: Murthy
authors.affiliation: Department of Radiation Oncology, Advanced Center for Treatment, Research, and Education in Cancer (ACTREC), Navi Mumbai, Maharashtra, India.
authors.forename: Sadhana
authors.initials: S
authors.lastname: Kannan
authors.affiliation: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors.forename: Jai Prakash
authors.initials: JP
authors.lastname: Agarwal
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020266:Radiotherapy, Conformal; D050397:Radiotherapy, Intensity-Modulated; D014987:Xerostomia / Q000517:prevention & control
keywords: conformal radiotherapy; head and neck cancer; intensity-modulated radiotherapy (IMRT); squamous cell carcinoma