title: A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results.
abstract: In the present manuscript we propose a lattice free multiscale model for avascular tumor growth that takes into account the biochemical environment, mitosis, necrosis, cellular signaling and cellular mechanics. This model extends analogous approaches by assuming a function that incorporates the biochemical energy level of the tumor cells and a mechanism that simulates the behavior of cancer stem cells. Numerical simulations of the model are used to investigate the morphology of the tumor at the avascular phase. The obtained results show similar characteristics with those observed in clinical data in the case of the Ductal Carcinoma In Situ (DCIS) of the breast.
authors.affiliation: School of Science and Technology, Hellenic Open University, Sachtouri 11, 26222 Patras, Greece.
authors.forename: Pantelis
authors.initials: P
authors.lastname: Ampatzoglou
authors.affiliation: Department of Chemical Engineering, University of Patras, Patras, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Dassios
authors.affiliation: School of Science and Technology, Hellenic Open University, Sachtouri 11, 26222 Patras, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Hadjinicolaou
authors.affiliation: Medical School, University of Patras, Patras, Greece.
authors.forename: Helen P
authors.initials: HP
authors.lastname: Kourea
authors.affiliation: Department of Mathematics, University of Patras, Patras, Greece.
authors.forename: Michael N
authors.initials: MN
authors.lastname: Vrahatis
keywords: ATP; Avascular; Breast cancer; Multi-scale model; Tumor growth