title: Vitamin D modulates adipose tissue biology: possible consequences for obesity?
abstract: Cross-sectional studies depict an inverse relationship between vitamin D (VD) status reflected by plasma 25-hydroxy-vitamin D and obesity. Furthermore, recent studies in vitro and in animal models tend to demonstrate an impact of VD and VD receptor on adipose tissue and adipocyte biology, pointing to at least a part-causal role of VD insufficiency in obesity and associated physiopathological disorders such as adipose tissue inflammation and subsequent insulin resistance. However, clinical and genetic studies are far less convincing, with highly contrasted results ruling out solid conclusions for the moment. Nevertheless, prospective studies provide interesting data supporting the hypothesis of a preventive role of VD in onset of obesity. The aim of this review is to summarise the available data on relationships between VD, adipose tissue/adipocyte physiology, and obesity in order to reveal the next key points that need to be addressed before we can gain deeper insight into the controversial VD-obesity relationship.
authors.affiliation: INRA,UMR 1260,F-13385,Marseille,France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Landrier
authors.affiliation: INRA,UMR 1260,F-13385,Marseille,France.
authors.forename: Esma
authors.initials: E
authors.lastname: Karkeni
authors.affiliation: INRA,UMR 1260,F-13385,Marseille,France.
authors.forename: Julie
authors.initials: J
authors.lastname: Marcotorchino
authors.affiliation: INRA,UMR 1260,F-13385,Marseille,France.
authors.forename: Lauriane
authors.initials: L
authors.lastname: Bonnet
authors.affiliation: INRA,UMR 1260,F-13385,Marseille,France.
authors.forename: Franck
authors.initials: F
authors.lastname: Tourniaire
keywords:  1;  25(OH)D 25-hydroxy-vitamin D;  CYP24A1 vitamin D 24-hydroxylase;  DBP vitamin D-binding protein;  MCP monocyte chemoattractant protein;  VD vitamin D;  VDR vitamin D receptor; 25(OH)2D 1; 25-dihydroxy-vitamin D; Adipocytes; Adipose tissue; Inflammation; Nutrients; Nutrition; Obesity; Vitamin D