title: Distinct roles of cortical and pallidal β and γ frequencies in hemiparkinsonian and dyskinetic rats.
abstract: Enhanced β band (βB) activity, which is suppressed by levodopa (LD) treatment, has been demonstrated within the basal ganglia (BG) of Parkinson's disease (PD) patients. However, some data suggest that Parkinsonian symptoms are not directly related to this brain frequency and therefore, its causative role remains questionable. A less explored phenomenon is the link between the γ band (γB) and PD phenomenology. Here, we monitored the development of the oscillatory activity during chronic LD depletion and LD treatment in Parkinsonian and levodopa-induced dyskinesia (LID) in rats. We found a significant and bilateral power increase in the high βB frequencies (20-30 Hz) within the first 10 days after 6-hydroxydopamine (6-OHDA) lesion, which was in accordance with a significant depletion of dopaminergic fibers in the striatum. We also observed a clear-cut γB increase during LD treatment. The development of LID was characterized by a slight increase in the cumulative power of βB accompanied by a large augmentation in the γB frequency (60-80 Hz). This latter effect reached a plateau in the frontal cortex bilaterally and the left globus pallidus after the second week of LD treatment. Our data suggest that the βB parallels the emergence of Parkinsonian signs and can be taken as a predictive sign of DA depletion, matching TH-staining reduction. On the other hand, the γB is strictly correlated to the development of LID. LD treatment had an opposite effect on βB and γB, respectively.
authors.affiliation: Laboratory for Biomedical Neuroscience (LBN), Neurocenter of Southern Switzerland, Lugano, Switzerland.
authors.forename: Agnese
authors.initials: A
authors.lastname: Salvadè
authors.affiliation: Department of Neurology, University of Rome "Tor Vergata", Italy.
authors.forename: Vincenza
authors.initials: V
authors.lastname: D'Angelo
authors.affiliation: Department of Physiology and Biochemistry, University of Malta, Malta.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Giovanni
authors.affiliation: Department of Neurology, University of Bern, Switzerland.
authors.forename: Gerd
authors.initials: G
authors.lastname: Tinkhauser
authors.affiliation: Department of Neurology, University of Rome "Tor Vergata", Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sancesario
authors.affiliation: Laboratory for Biomedical Neuroscience (LBN), Neurocenter of Southern Switzerland, Lugano, Switzerland.
authors.forename: Claudio
authors.initials: C
authors.lastname: Städler
authors.affiliation: Laboratory for Biomedical Neuroscience (LBN), Neurocenter of Southern Switzerland, Lugano, Switzerland; Parkinson Center, Center for Neurological Rehabilitation, Zihlschlacht, Switzerland.
authors.forename: Jens C
authors.initials: JC
authors.lastname: Möller
authors.affiliation: Department of Neurology, University of Rome "Tor Vergata", Italy; I.R.C.C.S. Fondazione S. Lucia, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Stefani
authors.affiliation: Laboratory for Biomedical Neuroscience (LBN), Neurocenter of Southern Switzerland, Lugano, Switzerland.
authors.forename: Alain
authors.initials: A
authors.lastname: Kaelin-Lang
authors.affiliation: Laboratory for Biomedical Neuroscience (LBN), Neurocenter of Southern Switzerland, Lugano, Switzerland. Electronic address: salvatore.galati@eoc.ch.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Galati
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology*; D004594:Electrophysiology; D005917:Globus Pallidus / Q000503:physiopathology*; D008297:Male; D010302:Parkinson Disease, Secondary / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
keywords: Beta band oscillation; Local field potentials; Parkinson's disease; Rat animal model; Recordings in freely moving animals