title: Impact of the nature and concentration of plasticizers on the ability of PVC to sorb drug.
abstract: The sorption of a drug by an infusion set may dramatically reduce the drug delivery efficiency. In this paper, we investigated how the drug sorption, in static conditions, is affected by the plasticizer's nature and ratio in the case of plasticized PVC, one of the most common material for infusion set tubing. Within the study, the drug concentration in diazepam solutions was studied after contact with PVC films containing different amounts of DEHP, DEHT, TOTM and DINCH® plasticizers. Moreover the partition coefficients between material and water were calculated. The drug sorption levels were equivalent for the different plasticizers and there was a plasticizer ratio for which the drug uptake was enhanced. As a consequence, the amount of sorbed drug might not be only linked to the amount of plasticizer in the film and to the solubility of the drug in the plasticizer alone: it must probably depend on specific interactions between plasticizer and PVC.
authors.affiliation: IFR 141, EA 401, UFR de Pharmacie, Université Paris, Sud-92290 Chatenay Malabry, France.
authors.forename: H
authors.initials: H
authors.lastname: Al Salloum
authors.affiliation: IFR 141, EA 401, UFR de Pharmacie, Université Paris, Sud-92290 Chatenay Malabry, France. Electronic address: johanna.saunier@u-psud.fr.
authors.forename: J
authors.initials: J
authors.lastname: Saunier
authors.affiliation: IFR 141, EA 401, UFR de Pharmacie, Université Paris, Sud-92290 Chatenay Malabry, France.
authors.forename: C
authors.initials: C
authors.lastname: Aymes-Chodur
authors.affiliation: IFR 141, EA 401, UFR de Pharmacie, Université Paris, Sud-92290 Chatenay Malabry, France.
authors.forename: H
authors.initials: H
authors.lastname: Barakat
authors.affiliation: IFR 141, EA 401, UFR de Pharmacie, Université Paris, Sud-92290 Chatenay Malabry, France.
authors.forename: N
authors.initials: N
authors.lastname: Yagoubi
mesh_terms: D003975:Diazepam / Q000378:metabolism*; D010968:Plasticizers / Q000737:chemistry* / Q000493:pharmacokinetics*; D011143:Polyvinyl Chloride / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D010968:Plasticizers; D011143:Polyvinyl Chloride; D003975:Diazepam
keywords: DEHP; Diazepam; Drug sorption; PVC; Partition coefficients; Plasticizer