title: Once-daily luliconazole cream 1% for the treatment of interdigital tinea pedis.
abstract: Luliconazole is an imidazole antifungal agent with a unique chemical structure. In this article, we summarize the in vitro data, animal studies and clinical trial data relating to the use of topical luliconazole cream 1% in the treatment of tinea pedis. Preclinical studies have demonstrated potent activity against dermatophytes. Luliconazole has strong fungicidal activity against Trichophyton spp., similar to that seen with terbinafine. Evidence from clinical trials in tinea pedis have shown once-daily application of luliconazole cream 1% for 14 days to be effective and well tolerated.
authors.affiliation: a Valeant Pharmaceuticals North America LLC , Bridgewater , NJ , USA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Gold
authors.affiliation: a Valeant Pharmaceuticals North America LLC , Bridgewater , NJ , USA.
authors.forename: Jason T
authors.initials: JT
authors.lastname: Olin
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic / Q000379:methods; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D014008:Tinea Pedis / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; C112528:luliconazole
keywords: efficacy; interdigital tinea pedis; luliconazole; once-daily; safety; short-course therapy