title: The synthesis and biological evaluation of a kabiramide C fragment modified with a WH2 consensus actin-binding motif as a potential disruptor of the actin cytoskeleton.
abstract: The F-actin depolymerisation potency of a fragment of kabiramide C was increased when modified with a WH2 consensus actin-binding motif LKKV. Despite its low affinity for actin monomers, a shorter analogous fragment not bearing LKKV was identified as a potent inhibitor of actin polymerisation and a promoter of its depolymerisation, resulting in a loss of actin stress fibres in cells.
authors.affiliation: Department of Chemistry, University of Liverpool, L69 7ZD, Liverpool, UK. aissa@liverpool.ac.uk.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Tetlow
authors.affiliation: Department of Biomedical Science, University of Sheffield, S10 2TN, UK. s.winder@sheffield.ac.uk.
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Winder
authors.affiliation: Department of Chemistry, University of Liverpool, L69 7ZD, Liverpool, UK. aissa@liverpool.ac.uk.
authors.forename: Christophe
authors.initials: C
authors.lastname: Aïssa
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry* / Q000378:metabolism; D000595:Amino Acid Sequence; D001685:Biological Factors; D010080:Oxazoles / Q000737:chemistry*; D011485:Protein Binding; D017434:Protein Structure, Tertiary
chemical_list: D001685:Biological Factors; D010080:Oxazoles; C489776:kabiramide C