title: [Oxidative stress: one of the major causes of vascular calcification in chronic kidney disease patients].
abstract: The leading cause of high mortality in dialyzed patients is cardiovascular disease. One of the main contributors of cardiovascular event is vascular calcification, which occurs even in very young patients. Multiple factors and complex mechanisms are involved in the formation of robust vascular calcification which affects a large vascular area observed in chronic kidney diseases. Patients on dialysis are exposed to enhanced oxidative stress as a result of increased pro-oxidant activity and reduced anti-oxidant systems. The oxidation of lipoprotein particles is implicated in the development of vascular damage representing oxidative threat, which leads to endothelial dysfunction. Moreover, in a pro-oxidant environment osteoblastic trans-differentiation of smooth muscle cells was shown to occur. Heme derived from oxidized hemoglobin might contribute to the formation of reactive lipid metabolites. This oxidative burden contributes to the development of atherosclerosis and vascular calcification. Heme oxygenase-1 and ferritin may serve as intracellular defense mechanisms against such an insult.
authors.affiliation: Belgyógyászati Klinika, Nephrológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.|Thrombosis-Haemostasis Kutatócsoport, MTA-DE Vascularis Biológia Debrecen.
authors.forename: Mónika
authors.initials: M
authors.lastname: Nyitrai
authors.affiliation: Gyermekgyógyászati Klinika, Neonatológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen.|Thrombosis-Haemostasis Kutatócsoport, MTA-DE Vascularis Biológia Debrecen.
authors.forename: György
authors.initials: G
authors.lastname: Balla
authors.affiliation: Belgyógyászati Klinika, Nephrológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.|Thrombosis-Haemostasis Kutatócsoport, MTA-DE Vascularis Biológia Debrecen.
authors.forename: József
authors.initials: J
authors.lastname: Balla
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000009:adverse effects*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism*; D061205:Vascular Calcification / Q000209:etiology* / Q000378:metabolism*
chemical_list: D006454:Hemoglobins; D008077:Lipoproteins, LDL; D017382:Reactive Oxygen Species; D007501:Iron
keywords: krónikus veseelégtelenség; oxidative stress; oxidatív stressz; oxidized LDL; oxidált LDL; renal insufficiency; vascular calcification; vascularis kalcifikáció