title: Inability to acquire spatial information and deploy spatial search strategies in mice with lesions in dorsomedial striatum.
abstract: Dorsal striatum has been shown to contribute to spatial learning and memory, but the role of striatal subregions in this important aspect of cognitive functioning remains unclear. Moreover, the spatial-cognitive mechanisms that underlie the involvement of these regions in spatial navigation have scarcely been studied. We therefore compared spatial learning and memory performance in mice with lesions in dorsomedial (DMS) and dorsolateral striatum (DLS) using the hidden-platform version of the Morris water maze (MWM) task. Compared to sham-operated controls, animals with DMS damage were impaired during MWM acquisition training. These mice displayed delayed spatial learning, increased thigmotaxis, and increased search distance to the platform, in the absence of major motor dysfunction, working memory defects or changes in anxiety or exploration. They failed to show a preference for the target quadrant during probe trials, which further indicates that spatial reference memory was impaired in these animals. Search strategy analysis moreover demonstrated that DMS-lesioned mice were unable to deploy cognitively advanced spatial search strategies. Conversely, MWM performance was barely affected in animals with lesions in DLS. In conclusion, our results indicate that DMS and DLS display differential functional involvement in spatial learning and memory. Our results show that DMS, but not DLS, is crucial for the ability of mice to acquire spatial information and their subsequent deployment of spatial search strategies. These data clearly identify DMS as a crucial brain structure for spatial learning and memory, which could explain the occurrence of neurocognitive impairments in brain disorders that affect the dorsal striatum.
authors.affiliation: Laboratory of Biological Psychology, University of Leuven, Belgium.
authors.forename: Tine
authors.initials: T
authors.lastname: Pooters
authors.affiliation: Laboratory of Biological Psychology, University of Leuven, Belgium; Sonenberg Laboratory, McGill University, Canada.
authors.forename: Ilse
authors.initials: I
authors.lastname: Gantois
authors.affiliation: Laboratory of Biological Psychology, University of Leuven, Belgium.
authors.forename: Ben
authors.initials: B
authors.lastname: Vermaercke
authors.affiliation: Laboratory of Biological Psychology, University of Leuven, Belgium. Electronic address: rudi.dhooge@ppw.kuleuven.be.
authors.forename: Rudi
authors.initials: R
authors.lastname: D'Hooge
mesh_terms: D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D007859:Learning Disabilities / Q000503:physiopathology*; D018782:Maze Learning / Q000502:physiology*; D008569:Memory Disorders / Q000503:physiopathology*; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology; D017072:Neostriatum / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011897:Random Allocation; D045442:Rotarod Performance Test; D065852:Spatial Memory / Q000502:physiology*; D065854:Spatial Navigation / Q000502:physiology*
keywords: Dorsal striatum; Morris water maze; Search strategy; Spatial learning; Spatial navigation; Thigmotaxis