title: Beyond Red Hair and Sunburns: Uncovering the Molecular Mechanisms of MC1R Signaling and Repair of UV-Induced DNA Damage.
abstract: Scientists at the University of Kentucky are unraveling the details of DNA-damage repair in the melanocyte, with an eye towards finding druggable targets for melanoma prevention. Jarret et al., (2015, this issue) report in this issue three new assays that can yield mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-dependent signaling downstream of the melanocortin-1 receptor (MC1R).
authors.affiliation: Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
authors.forename: Pamela B
authors.initials: PB
authors.lastname: Cassidy
authors.affiliation: Department of Dermatology, University of Cincinnati, Cincinnati, Ohio, USA.
authors.forename: Zalfa A
authors.initials: ZA
authors.lastname: Abdel-Malek
authors.affiliation: Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA. Electronic address: leachmas@ohsu.edu.
authors.forename: Sancy A
authors.initials: SA
authors.lastname: Leachman
mesh_terms: D004260:DNA Repair; D006801:Humans; D008544:Melanocytes / Q000378:metabolism*; D044102:Receptor, Melanocortin, Type 1 / Q000502:physiology*
chemical_list: D044102:Receptor, Melanocortin, Type 1