title: Effect of age and sex on bone markers in Chlorocebus aethiops raised in captivity.
abstract: BACKGROUND
  The objective was to evaluate the procollagen type I N-propeptide (PINP), osteocalcin (OC), β-crosslaps (β-CTX), and parathyroid hormone (PTH) in relation to age and sex of Chlorocebus aethiops in captivity.
  
  
  METHODS
  Seventy-three monkeys were divided into four age groups: AG1 (juvenile); AG2 (young adult); AG3 (adult); and AG4 (senile). An electrochemiluminescence immunoassay with an Elecsys 2010 analyzer was used to determine the serum markers of bone.
  
  
  CONCLUSIONS
  Sex did not influence the results of the markers. However, the variables PINP, OC, and β-CTX were negatively correlated with age (r = -0.643; r = -0.711; r = -0.488; P < 0.001, respectively), and PTH was correlated positively with age (r = 0.418, P < 0.001). The data obtained can be used as biomarkers of bone metabolism reference intervals in healthy C. aethiops in captivity.
authors.affiliation: Centro Nacional de Primatas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, PA, Brazil.|Programa de Pós-graduação de Saúde e Produção Animal da Amazônia, Universidade Federal Rural da Amazônia, Belém, PA, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Amaral Imbeloni
authors.affiliation: Departamento de Cirurgia Veterinária e Anestesiologia da, Faculdade de Medicina Veterinária de Zootecnia, Universidade Estadual Paulista, Botucatu, SP, Brazil.
authors.forename: Sheila
authors.initials: S
authors.lastname: Canevese Rahal
authors.affiliation: Programa de Pós-graduação de Saúde e Produção Animal da Amazônia, Universidade Federal Rural da Amazônia, Belém, PA, Brazil.
authors.forename: Ednaldo
authors.initials: E
authors.lastname: da Silva Filho
authors.affiliation: Programa de Pós-graduação de Saúde e Produção Animal da Amazônia, Universidade Federal Rural da Amazônia, Belém, PA, Brazil.
authors.forename: Bianca
authors.initials: B
authors.lastname: Mendonça Faria
authors.affiliation: Centro Nacional de Primatas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, PA, Brazil.|Programa de Pós-graduação de Saúde e Produção Animal da Amazônia, Universidade Federal Rural da Amazônia, Belém, PA, Brazil.
authors.forename: Wellington
authors.initials: W
authors.lastname: Bandeira da Silva
authors.affiliation: Centro Nacional de Primatas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, PA, Brazil.
authors.forename: Karol
authors.initials: K
authors.lastname: Guimarães Oliveira
authors.affiliation: Centro Nacional de Primatas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, PA, Brazil.
authors.forename: Mika Ester
authors.initials: ME
authors.lastname: Aihara
authors.affiliation: Programa de Pós-graduação de Saúde e Produção Animal da Amazônia, Universidade Federal Rural da Amazônia, Belém, PA, Brazil.
authors.forename: Frederico Ozanan
authors.identifier: http://orcid.org/0000-0002-1406-9979
authors.initials: FO
authors.lastname: Barros Monteiro
mesh_terms: D000367:Age Factors; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001774:Blood Chemical Analysis / Q000662:veterinary; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary*; D016723:Bone Remodeling / Q000502:physiology*; D002522:Chlorocebus aethiops / Q000097:blood / Q000502:physiology*; D003094:Collagen / Q000097:blood; D005260:Female; D006403:Hematologic Tests / Q000662:veterinary; D008297:Male; D008992:Monkey Diseases / Q000175:diagnosis* / Q000503:physiopathology; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D011347:Procollagen; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; C047202:procollagen Type I N-terminal peptide; D015675:Osteocalcin; D003094:Collagen
keywords: Cercopithecidae; bone formation markers of bone resorption markers; primates