title: Role of immune cells in salt-sensitive hypertension and renal injury.
abstract: OBJECTIVE
  Immune mechanisms exacerbate the severity of hypertension in humans and animal models of disease. This review summarizes recent mechanistic studies exploring the pathways whereby immunity influences salt-sensitive hypertension and renal disease.
  
  
  RESULTS
  Emphasis is placed on the role of T cell subtypes, the mechanisms of T-cell activation, and the identification of potential antigens or neoantigens.
  
  
  CONCLUSIONS
  Significant advancements have occurred in the search for pathways which activate the adaptive immune response. An enhanced understanding of the factors contributing to hypertension can lead to better therapies.
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors.forename: Brittany
authors.initials: B
authors.lastname: Wade
authors.forename: Justine M
authors.initials: JM
authors.lastname: Abais-Battad
authors.forename: David L
authors.initials: DL
authors.lastname: Mattson
mesh_terms: D056704:Adaptive Immunity; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000276:immunology; D047908:Intracellular Signaling Peptides and Proteins; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology; D008213:Lymphocyte Activation; D011506:Proteins / Q000235:genetics; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C490778:SH2B3 protein, human; D017673:Sodium Chloride, Dietary