title: Analytical detection of trimetazidine produced by metabolic conversion of lomerizine in doping control analysis.
abstract: The identification of trimetazidine in urine samples might result from administration of the permitted drug lomerizine. Laboratories are therefore urged to carefully investigate suspicious cases where trimetazidine is detected. Differentiation of abuse of the banned substance trimetazidine from use of the permitted drug lomerizine would be supported by analysis of the intact drug lomerizine and/or specific metabolites. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Anti-Doping Laboratory, LSI Medience Corporation, Tokyo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Okano
authors.affiliation: Institute of Biochemistry/Center for Preventive Doping Research, German Sport University Cologne, Cologne, Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Thevis
authors.affiliation: Anti-Doping Laboratory, LSI Medience Corporation, Tokyo, Japan.
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Sato
authors.affiliation: Anti-Doping Laboratory, LSI Medience Corporation, Tokyo, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kageyama
mesh_terms: D002121:Calcium Channel Blockers / Q000378:metabolism / Q000652:urine*; D002853:Chromatography, Liquid / Q000379:methods; D004300:Doping in Sports; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D010879:Piperazines / Q000378:metabolism / Q000652:urine*; D015813:Substance Abuse Detection / Q000379:methods*; D014292:Trimetazidine / Q000378:metabolism / Q000652:urine*; D014665:Vasodilator Agents / Q000378:metabolism / Q000652:urine*
chemical_list: D002121:Calcium Channel Blockers; D010879:Piperazines; D014665:Vasodilator Agents; C052424:lomerizine; D014292:Trimetazidine