title: The underlying mechanism of action for various medicinal properties of Piper betle (betel).
abstract: Piper betle (betel) plant belongs to the Piperaceae family. Piper. betle is widely known for its potent medicinal properties. Various active compounds are present in Piper. betle such as allylpyrocatechol, hydroxychavicol, piperbetol, ethylpiperbetol, piperol A, piperol B, chavibetol, and alkaloids which account for these beneficial medicinal properties. In the present narrative review, we looked into the various active compounds present in the Piper betle and attempted to understand their underlying mechanism of action. Proper understanding of the molecular biology involving the mechanism of action may help in better drug formulation and provide better therapeutic actions in the field of alternative and complementary medicine.
authors.affiliation: Department of Anatomy, 18th Floor, Pre-Clinical Block, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia - Anatomy Unit, Faculty of Medicine, UiTM Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor Darul Ehsan.
authors.forename: H
authors.initials: H
authors.lastname: Haslan
authors.affiliation: Department of Anatomy, 18th Floor, Pre-Clinical Block, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
authors.forename: F H
authors.initials: FH
authors.lastname: Suhaimi
authors.affiliation: Department of Anatomy, 18th Floor, Pre-Clinical Block, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
authors.forename: Zar Chi
authors.initials: ZC
authors.lastname: Thent
authors.affiliation: Department of Anatomy, 18th Floor, Pre-Clinical Block, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
authors.forename: S
authors.initials: S
authors.lastname: Das
mesh_terms: D000818:Animals; D000529:Complementary Therapies; D006801:Humans; D031721:Piper betle / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D010936:Plant Extracts
keywords: Analgesic; Anti-inflammatory; Anticancer; Antidiabetic; Antioxidant; Cardioprotective; Gastroprotective; Hepatoprotective; Piper betle; Radioprotective