title: Influence of the intervention of exercise on obese type II diabetes mellitus: A meta-analysis.
abstract: The study aimed to assess the effect of exercise intervention on the management of obese T2DM patients.
  
  
  
  The literature retrieval was conducted in relevant databases from their inception to 2015, with predefined searching strategy and selection criteria. The Cochrane Collaboration's tool was utilized to assess the quality of included studies. Weighted mean difference (WMD) with its corresponding 95% CI (confidence interval) was used as the effect size.
  
  
  
  A subset of 13 eligible studies was selected. Exercise significantly reduced the concentration of high sensitivity C reactive protein (4 months: WMD=-1.03, 95% CI: -1.77 to -0.29, P<0.01), triglyceride (6 months: WMD=-24.75, 95% CI: -27.67 to -21.83, P<0.01), diastolic blood pressure (6 months: WMD=-2.70, 95% CI: -4.12 to -1.28, P=0.0002), systolic blood pressure (WMD=-7.98, 95% CI: -9.87 to -6.08, P<0.01)), HbA1c (4 months: WMD=-0.25, 95% CI: -0.49 to -0.02, P=0.04) and homeostasis model assessment-insulin resistance (3 months: WMD=-0.19, 95% CI: -0.37 to -0.01, P=0.04); and a pronounced increase of HDL-C (12 months: WMD=3.57, 95% CI: 1.92 to 5.21, P<0.01).
  
  
  
  Exercise was beneficial to obese T2DM patients.
authors.affiliation: Department of Physical Education, Southwest University for Nationalities, Chendu, PR China; Department of Nutrition, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors.forename: Zhichun
authors.initials: Z
authors.lastname: Zou
authors.affiliation: Department of Nutrition, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
authors.affiliation: Department of Physical Education, Shanghai Jiao Tong University, 800 Dongchuan RD. Minhang District, Shanghai 200240, PR China. Electronic address: caimindhhd@hotmail.com.
authors.forename: Min
authors.initials: M
authors.lastname: Cai
authors.affiliation: Department of Physical Education, Southwest University for Nationalities, Chendu, PR China.
authors.forename: Mouyuan
authors.initials: M
authors.lastname: Xiao
authors.affiliation: Department of Physical Education, Southwest University for Nationalities, Chendu, PR China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D016009:Chi-Square Distribution; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006304:Health Status; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D016017:Odds Ratio; D012307:Risk Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D014280:Triglycerides; C517652:hemoglobin A1c protein, human
keywords: Cardiovascular disease; Exercise; High sensitivity C reactive protein; Meta-analysis; Obese; Type II diabetes mellitus