title: Kinetic Changes of Viremia and Viral Antigens of Hepatitis B Virus During and After Pregnancy.
abstract: Whether pregnancy may influence the replication of hepatitis B virus (HBV) remains unknown. The authors aimed to clarify this issue by observing the kinetics of HBV deoxyribonucleic acid (DNA) and viral antigens in women during and after pregnancy. Total, 371 pregnant women with positive hepatitis B surface antigen (HBsAg) were enrolled. Serial sera collected during and after pregnancy were quantitatively measured for HBV DNA, HBsAg, and hepatitis B e antigen (HBeAg). Total, 34 HBeAg-positive women underwent alanine aminotransferase (ALT) elevation during or after pregnancy; levels of HBV DNA and HBsAg in them showed no obvious change between second trimester or delivery and 7 to 12 months postpartum (P > 0.05). The 337 others had normal alanine aminotransferase levels during pregnancy and postpartum. In 147 HBeAg-positive women with follow-up 7 to 12 months postpartum, the average levels of HBV DNA (>7.0 log10 IU/mL), HBsAg (>4.0 log10 IU/mL), and HBeAg (>3.0 log10 S/CO) were longitudinally constant during pregnancy and postpartum, respectively. In 173 women with follow-up 4.8 years postpartum, neither HBV DNA levels nor antigen titers showed significant difference between second trimester and 4.8 years postpartum, regardless of the HBeAg status. In addition, levels of HBV DNA and viral antigens in second trimester, around delivery, 6 to 8 weeks and 7 to 12 months postpartum showed no marked fluctuations, respectively. Serum levels of HBV DNA and viral antigens in HBsAg-positive women are highly constant during pregnancy and postpartum, regardless of the HBeAg status and alanine aminotransferase levels. This demonstrates that pregnancy has little influence on the HBV replication and antigen expression.
authors.affiliation: From the Department of Experimental Medicine (JL, YB, MP, Y-HZ), Jiangsu Key Laboratory for Molecular Medicine (JL, MP, YH, Y-HZ); Department of Obstetrics and Gynecology (JC, YH); Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Jiangsu, China (Y-HZ); Zhenjiang Fourth People's Hospital (CX, TC); and Department of Obstetrics and Gynecology, Taixing People's Hospital, Jiangsu, China (LL, BX).
authors.forename: Jingli
authors.initials: J
authors.lastname: Liu
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Bi
authors.forename: Chenyu
authors.initials: C
authors.lastname: Xu
authors.forename: Lanhua
authors.initials: L
authors.lastname: Liu
authors.forename: Biao
authors.initials: B
authors.lastname: Xu
authors.forename: Tingmei
authors.initials: T
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Mingjie
authors.initials: M
authors.lastname: Pan
authors.forename: Yali
authors.initials: Y
authors.lastname: Hu
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D015415:Biomarkers; D004279:DNA, Viral / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D011247:Pregnancy; D014766:Viremia / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D015415:Biomarkers; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D000410:Alanine Transaminase