title: Adding value to plant oils and fatty acids: Biological transformation of fatty acids into ω-hydroxycarboxylic, α,ω-dicarboxylic, and ω-aminocarboxylic acids.
abstract: Not only short chain ω-hydroxycarboxylic acids, α,ω-dicarboxylic acids, and ω-aminocarboxylic acids but also medium to long chain carboxylic acids are widely used as building blocks and intermediates in the chemical, pharmaceutical, and food industries. Thereby, recent achievements in biological production of medium to long chain carboxylic acids are addressed here. ω-Hydroxycarboxylic and α,ω-dicarboxylic acids were synthesized via terminal CH bond oxygenation of fatty acids and/or internal oxidative cleavage of the fatty acid carbon skeletons. ω-Aminocarboxylic acids were enzymatically produced from ω-hydroxycarboxylic acids via ω-oxocarboxylic acids. Productivities and product yields of some of the products are getting close to the industrial requirements for large scale production.
authors.affiliation: Department of Food Science and Engineering, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Joo-Hyun
authors.initials: JH
authors.lastname: Seo
authors.affiliation: Division of Food Science, Kyungil University, Gyeongsan 712-701, Republic of Korea.
authors.forename: Sun-Mee
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 121-742, Republic of Korea.
authors.forename: Jinwon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Food Science and Engineering, Ewha Womans University, Seoul 120-750, Republic of Korea. Electronic address: jbpark06@ewha.ac.kr.
authors.forename: Jin-Byung
authors.initials: JB
authors.lastname: Park
mesh_terms: D053898:Biosynthetic Pathways; D001711:Biotransformation; D003998:Dicarboxylic Acids / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D010938:Plant Oils / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D003998:Dicarboxylic Acids; D005227:Fatty Acids; D010938:Plant Oils
keywords: Biotransformation; Fatty acids; α,ω-Dicarboxylic acids; ω-Aminocarboxylic acids; ω-Hydroxycarboxylic acids