title: Mitogen-Activated Protein Kinase Kinase 4 Gene Polymorphism and Cancer Risk.
abstract: A number of epidemiological studies have assessed the association of -1304T > G polymorphism in the MKK4 gene and risk of cancer, but the results lack of statistical power due to the limited subjects used in these studies. This study was devised to identify the genetic effects of the -1304T > G polymorphism on cancer risk in a large meta-analysis.Eligible studies were identified by searching both Chinese and English databases. General as well as subgroup analyses were performed for 8 independent case-control publications with a total of 4623 cases and 5256 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association.Overall, this meta-analysis showed that the association between the -1304T > G polymorphism and cancer risk was statistically significant (GG vs TT: OR = 0.63, 95% CI, 0.52-0.75; GG + TG vs TT: OR = 0.85, 95% CI, 0.79-0.91; GG vs TG + TT: OR = 0.67, 95% CI, 0.56-0.80; G vs T: OR = 0.82, 95% CI, 0.77-0.88; TG vs TT: OR = 0.86, 95% CI, 0.79-0.93).Our meta-analysis reveals that the presence of the -1304T > G polymorphism is likely to decrease risk of cancer. Future larger studies are necessary to validate the current finding.
authors.affiliation: From the Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Peiliang
authors.initials: P
authors.lastname: Geng
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Ou
authors.forename: Ganfeng
authors.initials: G
authors.lastname: Xie
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Zhao
authors.forename: Lisha
authors.initials: L
authors.lastname: Xiang
authors.forename: Yunmei
authors.initials: Y
authors.lastname: Liao
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Houjie
authors.initials: H
authors.lastname: Liang
mesh_terms: D004247:DNA / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D048670:MAP Kinase Kinase 4 / Q000235:genetics*; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D004247:DNA; D048670:MAP Kinase Kinase 4