title: Stromal vascular fraction: A regenerative reality? Part 2: Mechanisms of regenerative action.
abstract: Adipose tissue is a rich source of cells with emerging promise for tissue engineering and regenerative medicine. The stromal vascular fraction (SVF), in particular, is an eclectic composite of cells with progenitor activity that includes preadipocytes, mesenchymal stem cells, pericytes, endothelial cells, and macrophages. SVF has enormous potential for therapeutic application and is being investigated for multiple clinical indications including lipotransfer, diabetes-related complications, nerve regeneration, burn wounds and numerous others. In Part 2 of our review, we explore the basic science behind the regenerative success of the SVF and discuss significant mechanisms that are at play. The existing literature suggests that angiogenesis, immunomodulation, differentiation, and extracellular matrix secretion are the main avenues through which regeneration and healing is achieved by the stromal vascular fraction.
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, United States.
authors.forename: James
authors.initials: J
authors.lastname: Guo
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, United States.
authors.forename: Andrew
authors.initials: A
authors.lastname: Nguyen
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, United States.
authors.forename: Derek A
authors.initials: DA
authors.lastname: Banyard
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, United States.
authors.forename: Darya
authors.initials: D
authors.lastname: Fadavi
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, United States.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Toranto
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, United States.
authors.forename: Garrett A
authors.initials: GA
authors.lastname: Wirth
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, United States.
authors.forename: Keyianoosh Z
authors.initials: KZ
authors.lastname: Paydar
authors.affiliation: Department of Plastic Surgery, University of California, Irvine, United States.
authors.forename: Gregory R D
authors.initials: GR
authors.lastname: Evans
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, United States. Electronic address: awidgero@uci.edu.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Widgerow
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D002454:Cell Differentiation; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D044968:Regenerative Medicine / Q000379:methods*; D017154:Stromal Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*
keywords: Adipose; Adipose-derived stem cells (ADSCs); Lipoaspirate; Regenerative medicine; Stromal vascular fraction (SVF)