title: A new biflavonoid from the whole herb of Lepisorus ussuriensis.
abstract: A new biflavonoid, 7-O-methylnaringenin-(4'→O→6″)-scutellarein (1), together with 11 known compounds (2-12) were isolated from the whole herb of Lepisorus ussuriensis. The structure of compound 1 was elucidated by spectroscopic analyses. Amongst them, dihydroquercetin (6), diosmetin (9), baicalein (11) and 7,8-dihydroxyflavone (12) were reported from the family Polypodiaceae for the first time. Meanwhile, quercetin (7), diosmetin (9) and luteolin (10) inhibited TNF-α-induced NF-κB reporter gene expression on HeLa cells up to 30 and 100 μM.
authors.affiliation: a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.|b Department of Pharmacy No. 202 Hospital of People's Liberation Army , Shenyang , P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.affiliation: a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Cao
authors.affiliation: a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.|c Department of Pharmacy , Yanbian University Hospital , Yanji , P.R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.affiliation: a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.
authors.forename: Changhao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Jin
authors.affiliation: a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.
authors.forename: Jiongmo
authors.initials: J
authors.lastname: Cui
authors.affiliation: a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.
authors.forename: Gao
authors.initials: G
authors.lastname: Li
mesh_terms: D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D029621:Polypodiaceae / Q000737:chemistry*
chemical_list: D044946:Biflavonoids
keywords: Lepisorus ussuriensis; Polypodiaceae; anti-inflammatory activity; biflavonoid; nuclear factor-κB (NF-κB)