title: Pulmonary Embolism in Ambulatory Oncologic Patients.
abstract: BACKGROUND
  The association between cancer and venous thromboembolism is known, and oncology patients present a risk six to seven times higher than the general population of a thrombotic event. Pulmonary embolism is an important cause of morbidity and mortality in this patients group, presenting an underestimated prevalence.
  
  
  METHODS
  Retrospective study of all episodes of pulmonary embolism referenced in the last five years. We only selected oncologic outpatients and studied their demographics characteristics, risk factors associated with venous thromboembolism, presence of symptoms at diagnosis, risk stratification of venous thromboembolic events by the Khorana model, probability of mortality at 30 days and overall survival. The study is in accordance with the Helsinki declaration.
  
  
  RESULTS
  From the 186 patients under evaluation, 55.9% were female, with median age of 64 years. The most prevalent cancers were colorectal (24.2%) and lung (17.7%), most of which had metastases (66.1%) or underwent chemotherapy (69.4%). Pulmonary embolism was a radiological finding in 69.4%, whereas no clinical variable was relevant for the presence or absence of symptoms. Mortality at 30 day resulting from pulmonary embolism was 7.5%, and it was found that symptomatic patients had a lower median survival relative to asymptomatic (12 vs. 20 months, p = 0.029). The retrospective application of the Khorana model to those undergoing chemotherapy identified 11% of individuals at high risk.
  
  
  CONCLUSIONS
  Pulmonary thromboembolism was an imagiological finding in most patients, with no clinical variable able to predict the presence or absence of symptoms. Asymptomatic patients had a higher survival.
  
  
  CONCLUSIONS
  In our study pulmonary embolism was apparently asymptomatic in most study patients. These data reinforce the need to evaluate the risk of venous thromboembolism in cancer outpatients and consider conducting antithrombotic prophylaxis.
authors.affiliation: Serviço de Onco-Hematologia. Instituto Português de Oncologia Francisco Gentil. Porto. Portugal.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Silva
authors.affiliation: Serviço de Imuno-Hemoterapia. Instituto Português de Oncologia Francisco Gentil. Porto. Portugal.
authors.forename: Maria
authors.initials: M
authors.lastname: Rosales
authors.affiliation: Serviço de Imuno-Hemoterapia. Instituto Português de Oncologia Francisco Gentil. Porto. Portugal.
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Milheiro
authors.affiliation: Serviço de Imuno-Hemoterapia. Instituto Português de Oncologia Francisco Gentil. Porto. Portugal.
authors.forename: Luísa L
authors.initials: LL
authors.lastname: Santos
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications*; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D054556:Venous Thromboembolism; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology*