title: Angiotensinogen polymorphism and ischemic stroke risk.
abstract: The angiotensinogen M235T polymorphism was associated with ischemic stroke risk. However, the results were controversial. Thus, a meta-analysis was conducted. NCBI, Medline, Web of Science and Embase databases were systematically searched. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. There was a significant association between angiotensinogen M235T polymorphism and ischemic stroke risk (OR = 1.69; 95% CI, 1.35-2.11; P < 0.001). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with ischemic stroke in Asian (OR = 1.85; 95% CI, 1.45-2.35; P < 0.001). In the age subgroup, we found that angiotensinogen M235T polymorphism could increase both early-onset ischemic stroke risk (OR = 1.88; 95% CI, 1.33-2.43; P < 0.001) and late-onset ischemic stroke risk (OR = 1.20; 95% CI, 1.01-1.39; P = 0.04). This meta-analysis suggested that angiotensinogen M235T polymorphism was associated with ischemic stroke.
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Bao
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Hao
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Yang
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Xia-Hong
authors.initials: XH
authors.lastname: Xu
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Zuo
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Si-Yi
authors.initials: SY
authors.lastname: Xu
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurology, Shanghai East Hospital Shanghai 200123, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
keywords: Ischemic stroke; angiotensinogen; genetic; meta-analysis