title: [Antioxidants--antioxidative stress: facts and questions, 2015].
abstract: In the past years great importance has been attributed to antioxidant therapy in the prevention and treatment of disorders developed in connection with oxidative stress. After initial success, undesirable effects, toxicities, and prooxidant effects of antioxidants were reported [CARET, ATBC study]. In addition, metaanalyses failed to confirm the role of antioxidant supplementation in the primary and secondary prevention. The authors review the prooxidant effects of antioxidants, and their role in cell signalling and cell process modulation. Finally, the authors summarize possible explanations why combined use of antiooxidants is more favourable.
authors.affiliation: II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Szentkirályi u. 46., 1088.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Hagymási
authors.affiliation: II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Szentkirályi u. 46., 1088.
authors.forename: Anna
authors.initials: A
authors.lastname: Egresi
authors.affiliation: II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Szentkirályi u. 46., 1088.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Lengyel
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D019587:Dietary Supplements; D004359:Drug Therapy, Combination; D005419:Flavonoids / Q000494:pharmacology; D006801:Humans; D016877:Oxidants / Q000008:administration & dosage / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects*; D059808:Polyphenols / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*; D014801:Vitamin A / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*; D019207:beta Carotene / Q000494:pharmacology
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D005419:Flavonoids; D016877:Oxidants; D059808:Polyphenols; D014815:Vitamins; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D001205:Ascorbic Acid
keywords: antioxidant vitamins; antioxidative stress; antioxidáns vitaminok; antioxidánsstressz; cell signalling; jelátviteli folyamatok; oxidative stress; oxidatív stressz; prooxidant; prooxidáns