title: 99mTc-HYNIC-TOC increased uptake can mimic malignancy in the pancreas uncinate process at somatostatin receptor SPECT/CT.
abstract: OBJECTIVE
  The aim of this study was to assess the occurrence and frequency of increased physiologic uptake of 99mTc-HYNIC-TOC by the uncinate process of the pancreas in SPECT/CT images.
  
  
  METHODS
  Forty-six scans of 41 patients were evaluated retrospectively. The uptake of 99mTc-HYNIC-TOC was considered to be physiologic in patients with normal findings at dedicated abdominal CT or MR and lack of neoplastic lesions in clinical follow-ups. The intensity of uncinate process uptake was compared to the uptake of the normal liver.
  
  
  RESULTS
  Focal uptake was attributed to the presence of pancreatic NET in 5 patients. Among the 36 patients without any evidence of malignancy in CT, MR and follow-up, 7 (19.4 %) showed increased uptake in the uncinate process. The intensity of uptake was lesser in 3 (8.3 %), similar in 3 and greater than the normal liver in 1 (2.8 %) case.
  
  
  CONCLUSIONS
  Increased 99mTc-HYNIC-TOC uptake occurred in 19.4 % of those subjects without any evidence of neuroendocrine tumor in the uncinate process.
authors.affiliation: Imaging Department, Albert Einstein Hospital, Av. Albert Einstein, 627, São Paulo, CEP: 05651-090, Brazil. itayay@hotmail.com.
authors.forename: Lilian Yuri Itaya
authors.identifier: http://orcid.org/0000-0002-0223-7381
authors.initials: LY
authors.lastname: Yamaga
authors.affiliation: Imaging Department, Albert Einstein Hospital, Av. Albert Einstein, 627, São Paulo, CEP: 05651-090, Brazil.
authors.forename: Guilherme Campos Carvalho
authors.initials: GC
authors.lastname: Neto
authors.affiliation: Imaging Department, Albert Einstein Hospital, Av. Albert Einstein, 627, São Paulo, CEP: 05651-090, Brazil.
authors.forename: Marcelo Livorsi
authors.initials: ML
authors.lastname: da Cunha
authors.affiliation: Imaging Department, Albert Einstein Hospital, Av. Albert Einstein, 627, São Paulo, CEP: 05651-090, Brazil.
authors.forename: Akemi
authors.initials: A
authors.lastname: Osawa
authors.affiliation: Imaging Department, Albert Einstein Hospital, Av. Albert Einstein, 627, São Paulo, CEP: 05651-090, Brazil.
authors.forename: Julio Cesar Silveira
authors.initials: JC
authors.lastname: Oliveira
authors.affiliation: Imaging Department, Albert Einstein Hospital, Av. Albert Einstein, 627, São Paulo, CEP: 05651-090, Brazil.
authors.forename: Ricardo Quartim
authors.initials: RQ
authors.lastname: Fonseca
authors.affiliation: Imaging Department, Albert Einstein Hospital, Av. Albert Einstein, 627, São Paulo, CEP: 05651-090, Brazil.
authors.forename: Solange Amorim
authors.initials: SA
authors.lastname: Nogueira
authors.affiliation: Imaging Department, Albert Einstein Hospital, Av. Albert Einstein, 627, São Paulo, CEP: 05651-090, Brazil.
authors.forename: Jairo
authors.initials: J
authors.lastname: Wagner
authors.affiliation: Imaging Department, Albert Einstein Hospital, Av. Albert Einstein, 627, São Paulo, CEP: 05651-090, Brazil.
authors.forename: Marcelo Gusmão
authors.initials: MG
authors.lastname: Funari
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D018358:Neuroendocrine Tumors / Q000175:diagnosis; D015282:Octreotide / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010179:Pancreas / Q000378:metabolism*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D017481:Receptors, Somatostatin; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C410263:technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; D015282:Octreotide
keywords: 99mTc-HYNIC-Tyr3-octreotide; Neuroendocrine tumors; SPECT-CT; Somatostatin receptor imaging