title: Regulation of synthesis and roles of hyaluronan in peritoneal dialysis.
abstract: Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan composed of repeated disaccharide units of alternating D-glucuronic acid and D-N-acetylglucosamine residues linked via alternating β-1,4 and β-1,3 glycosidic bonds. HA is synthesized in humans by HA synthase (HAS) enzymes 1, 2, and 3, which are encoded by the corresponding HAS genes. Previous in vitro studies have shown characteristic changes in HAS expression and increased HA synthesis in response to wounding and proinflammatory cytokines in human peritoneal mesothelial cells. In addition, in vivo models and human peritoneal biopsy samples have provided evidence of changes in HA metabolism in the fibrosis that at present accompanies peritoneal dialysis treatment. This review discusses these published observations and how they might contribute to improvement in peritoneal dialysis.
authors.affiliation: Wales Kidney Research Unit, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: Bowen
authors.affiliation: Wales Kidney Research Unit, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
authors.forename: Soma
authors.initials: S
authors.lastname: Meran
authors.affiliation: Wales Kidney Research Unit, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
authors.forename: Aled P
authors.initials: AP
authors.lastname: Williams
authors.affiliation: Wales Kidney Research Unit, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
authors.forename: Lucy J
authors.initials: LJ
authors.lastname: Newbury
authors.affiliation: Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstrasse 1, 80336 München, Germany ; Klinikum Kempten, Robert-Weixler-Strasse 50, 87439 Kempten, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Sauter
authors.affiliation: Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstrasse 1, 80336 München, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sitter
mesh_terms: D015314:Dialysis Solutions / Q000737:chemistry / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000096:biosynthesis*; D008954:Models, Biological; D010530:Peritoneal Dialysis / Q000379:methods*; D010537:Peritoneum / Q000166:cytology / Q000378:metabolism*
chemical_list: D015314:Dialysis Solutions; D006820:Hyaluronic Acid