title: Alterations in Gene Expression in Depression: Prospects for Personalize Patient Treatment.
abstract: The number of people around the world suffering from depression has dramatically increased in last few decades. It has been predicted that by 2020 depression will become the second most common cause of disability. Furthermore, depression is often misdiagnosed and confused with other psychiatric disorders showing similar symptoms, i.e., anxiety and bipolar disorder, due to the fact that diagnosing is often carried out by medical workers who are not psychiatrically trained. These facts prompt us to prepare this review which focuses on alterations in gene expression in depression. We believe that an in-depth knowledge of molecular bases of behavior in depression and other mood disorders would be of a great benefit for the correct diagnosing of these disorders, as well as for prescribing a treatment that best suits each individual depending on expression alterations in depression-related genes. Therefore, the main aim of this review is to promote further translational research on the biochemistry of mood disorders and take the results further for the design of new targeted therapeutics that can be used for personalized treatment with minimal adverse effects.
authors.affiliation: Biomed Consult Ltd., Swansea, United Kingdom. Electronic address: rossen.donev@biomedconsult.co.uk.
authors.forename: Rossen
authors.initials: R
authors.lastname: Donev
authors.affiliation: Forensic Medicine Department, Ministry of Interior, Kuwait City, Kuwait.
authors.forename: Khaled
authors.initials: K
authors.lastname: Alawam
mesh_terms: D000928:Antidepressive Agents / Q000737:chemistry / Q000627:therapeutic use; D001007:Anxiety / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D002940:Circadian Rhythm / Q000235:genetics; D003863:Depression / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D058990:Molecular Targeted Therapy; D018377:Neurotransmitter Agents / Q000096:biosynthesis / Q000235:genetics; D057285:Precision Medicine; D014176:Protein Biosynthesis / Q000235:genetics*; D015398:Signal Transduction; D013569:Synapses / Q000235:genetics
chemical_list: D000928:Antidepressive Agents; D018377:Neurotransmitter Agents
keywords: Antidepressants; Depression; Gene expression; Major depressive disorder; Mood disorders; Personalized treatment