title: [Polymorphism in the Serotonin Transporter Gene (SLC6A4) and Emotional Bipolar Disorder in Two Regional Mental Health Centers from the Eje Cafetero (Colombia)].
abstract: BACKGROUND
  The indel polymorphisms in the promoting region and the 2(nd) intron polymorphisms in the serotonin transporter gene (SLC6A4) have been associated to bipolar disorder 1 (BD1) in several population studies. The objective was to analyze the genotypic and allelic frequencies in both gene regions in a study of cases and controls with individuals from Risaralda and Quindío (Colombia) so as to establish possible associations to BD1, and compare results with previous and similar studies.
  
  
  METHODS
  133 patients and 120 controls were studied. L and S indel polymorphisms in the promoting region were analyzed by PCR, together with VNTR STin2.10 and STin 2.12 VNTRs polymorphisms in the 2(nd) intron of the SL-C6A4 gene
  
  
  RESULTS
  Genotypic and allelic frequencies for the S and L polymorphisms were similar both in cases and controls. However, the LL genotype was significantly increased both in BD1 population (OR=1.89; CI95%=1.1-3.68), and when discriminated by gender. This particular genotype in general population is OR=2.22; IC95%=1.04-5.66 for women, and OR=1.62; IC 95%=0.71-4.39 for men. No significant genotypic and allelic differences were found for VNTR STin2.10 and STin 2.12. polymorphisms.
  
  
  CONCLUSIONS
  No association was found between polymorphisms of 5-HTTLPR polymorphisms and the 2(nd) intron of the serotonin transporting gene in general patients with BD1, nor when compared by gender. Our results are similar to those reported for Caucasian populations and differ from those of Asian and Brazilian populations.
authors.affiliation: Magíster en Biología Molecular y Biotecnología, Centro de Biología Molecular y Biotecnología de la Universidad Tecnológica de Pereira, vereda La Julita, Pereira, Risaralda, Colombia. Electronic address: cenbiotep@utp.edu.co.
authors.forename: Lucero Rengifo
authors.initials: LR
authors.lastname: Ramos
authors.affiliation: Magíster en Biología Molecular y Biotecnología, Centro de Biología Molecular y Biotecnología de la Universidad Tecnológica de Pereira, vereda La Julita, Pereira, Risaralda, Colombia.
authors.forename: Duverney Gaviria
authors.initials: DG
authors.lastname: Arias
authors.affiliation: Psiquiatra, directora científica del Instituto Especializado en Salud Mental, Clínica El Prado, Armenia, Quindío, Colombia.
authors.forename: Liliana Salazar
authors.initials: LS
authors.lastname: Salazar
authors.affiliation: Médico, subdirector científico del Hospital Mental de Risaralda (HOMERIS), Pereira, Risaralda, Colombia.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Vélez
authors.affiliation: Psicóloga, estudiante de Maestría en Biología Molecular y Biotecnología de la Universidad Tecnológica de Pereira, vereda La Julita, Pereira, Risaralda, Colombia.
authors.forename: Stella Lozano
authors.initials: SL
authors.lastname: Pardo
keywords: 2(nd) intron; Serotonin transporter; Transportador de serotonina; allelic frequency; frecuencias alélicas; frecuencias genotipicas; genotype frequency; promoter; promotor; segundo intron