title: Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma.
abstract: OBJECTIVE
  To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation (PEX) syndrome and pseudoexfoliative glaucoma (PEG) and to measure paraoxonase (PON) and arylesterase (ARE) levels.
  
  
  METHODS
  A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases, other than the diagnosis of cataract as control. Total oxidative stress (TOS), total antioxidant capacity (TAC), PON, and ARE levels in aqueous humor and serum were measured.
  
  
  RESULTS
  TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group (P<0.05). TOS values were higher in patients with PEX syndrome and PEG than controls (P<0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups.
  
  
  CONCLUSIONS
  These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG.
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey.
authors.forename: Feyza
authors.initials: F
authors.lastname: Dursun
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Vural Ozec
authors.affiliation: Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas 58140, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aydin
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey.
authors.forename: Aysen
authors.initials: A
authors.lastname: Topalkara
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dursun
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey.
authors.forename: Mustafa Ilker
authors.initials: MI
authors.lastname: Toker
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey.
authors.forename: Haydar
authors.initials: H
authors.lastname: Erdogan
authors.affiliation: Department of Ophthalmology, Cumhuriyet University School of Medicine, Sivas 58140, Turkey.
authors.forename: Mustafa Kemal
authors.initials: MK
authors.lastname: Arici
keywords: arylesterase; oxidative stress; paraoxonase; pseudoexfoliation syndrome