title: Avatars Identify Genetic Sources of Drug Response.
abstract: Using mouse avatars implanted with liver metastases of late-stage colorectal cancers, researchers uncovered mutations in five genes-ERBB2, EGFR, FGFR1, PDGFRA, and MAP2K1-that seem to promote cetuximab resistance. They also found that mutations in IRS2 may boost tumors' vulnerability to anti-EGFR therapy and tested specific therapies in the mice to gauge the drugs' effectiveness.
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols; D000068818:Cetuximab / Q000494:pharmacology / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D059472:Exome; D051379:Mice; D009154:Mutation / Q000187:drug effects; D010671:Phenylurea Compounds / Q000494:pharmacology / Q000627:therapeutic use; D057285:Precision Medicine; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D017422:Sequence Analysis, DNA; D023041:Xenograft Model Antitumor Assays
chemical_list: D010671:Phenylurea Compounds; D011743:Pyrimidines; C568950:infigratinib; D000068818:Cetuximab