title: Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats.
abstract: The research tries to establish Wistar rat's model of atherosclerosis for evaluating the antiatherosclerotic effect of hederagenin and exploring its antiatherosclerosis-related mechanisms. The statistical data have shown that hederagenin exhibits multiple pharmacological activities in the treatment of hyperlipidemia, antiplatelet aggregation, liver protection, and anti-inflammation, indicating that hederagenin may exert a protective effect on vascular walls by improving lipid metabolism disorders and lipid deposition. The results show that hederagenin can correct the imbalance of endothelial function by inhibiting the release of large amounts of iNOS and increasing eNOS contents and inhibits the IKKβ/NF-κB signaling pathway to reduce the release of IL-6, IFN-γ, TNF-α, and other inflammatory factors. The experimental results indicated that hederagenin can inhibit or ameliorate the pathological changes associated with AS, displaying an excellent preventive function against AS.
authors.affiliation: Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China.
authors.forename: Su-Hong
authors.initials: SH
authors.lastname: Lu
authors.affiliation: Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Guan
authors.affiliation: Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Huang
authors.affiliation: Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China.
authors.forename: Yu-Wei
authors.initials: YW
authors.lastname: Pan
authors.affiliation: Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Lan
authors.affiliation: Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China.
authors.forename: Si
authors.initials: S
authors.lastname: Huang
authors.affiliation: The First Affiliated Hospital of Jinan University, 613 Huangpu Road West, Guangzhou, Guangdong 510632, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, China.
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Zhao