title: Mechanisms of hypothermia-induced cell protection in the brain.
abstract: Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia remain to be elucidated. Therefore, in this brief overview we discuss both the clinical evidence and molecular mechanisms of therapeutic hypothermia in order to provide further insights into this promising intervention.
authors.affiliation: Department of Congenital Heart Disease/Pediatric Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. katharina.schmitt@charite.de.
authors.forename: Katharina Rose Luise
authors.initials: KR
authors.lastname: Schmitt
authors.affiliation: Department of Congenital Heart Disease/Pediatric Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. giang.tong@charite.de.
authors.forename: Giang
authors.initials: G
authors.lastname: Tong
authors.affiliation: Department of Congenital Heart Disease/Pediatric Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. felix.berger@charite.de.|Department of Pediatric Cardiology, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany. felix.berger@charite.de.
authors.forename: Felix
authors.initials: F
authors.lastname: Berger
keywords: Anoxic injury; Hypothermia; Inflammation; Neuroprotection; RBM3