title: Oxidation of NADH and ROS production by respiratory complex I.
abstract: Kinetic characteristics of the proton-pumping NADH:quinone reductases (respiratory complexes I) are reviewed. Unsolved problems of the redox-linked proton translocation activities are outlined. The parameters of complex I-mediated superoxide/hydrogen peroxide generation are summarized, and the physiological significance of mitochondrial ROS production is discussed. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt.
authors.affiliation: Department of Biochemistry, School of Biology, Moscow State University, Moscow 119991. Electronic address: adv@biochem.bio.msu.su.
authors.forename: Andrei D
authors.initials: AD
authors.lastname: Vinogradov
authors.affiliation: Department of Biochemistry, School of Biology, Moscow State University, Moscow 119991.
authors.forename: Vera G
authors.initials: VG
authors.lastname: Grivennikova
mesh_terms: D004579:Electron Transport; D042967:Electron Transport Complex I / Q000737:chemistry* / Q000648:ultrastructure*; D004789:Enzyme Activation; D008956:Models, Chemical; D056004:Molecular Dynamics Simulation; D009243:NAD / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D011487:Protein Conformation; D017494:Proton Pumps / Q000737:chemistry* / Q000648:ultrastructure*; D017382:Reactive Oxygen Species / Q000138:chemical synthesis*
chemical_list: D017494:Proton Pumps; D017382:Reactive Oxygen Species; D009243:NAD; D042967:Electron Transport Complex I
keywords: Bacterial plasma membranes; Hydrogen peroxide; Mitochondria; NADH:quinone oxidoreductase; Proton pumping; Superoxide