title: Is there a role for antifibrinolytics in pelvic and acetabular fracture surgery?
abstract: BACKGROUND
  Pelvic and acetabular fractures are rare, complex injuries associated with significant morbidity. Fixation of these injuries requires major orthopaedic surgery which in itself is associated with substantial blood loss owing to the extensile operative approach and prolonged operating time required to address the complex fracture anatomy. In order to reduce morbidity, a multifactor approach to blood conservation must be adopted.
  The use of antifibrinolytics to reduce operative blood loss is well documented in many surgical specialties, including orthopaedic surgery. Elective spinal surgery and joint arthroplasty have benefited from the introduction of antifibrinolytics; however, their role in trauma and fracture surgery is not fully defined. Pelvic and acetabular fracture surgery would benefit from further investigation on the benefit and safety of these agents.
  
  
  CONCLUSIONS
  Routine use cannot be recommended at this time but agents may be considered on a case-specific basis.
authors.affiliation: Department of Trauma and Orthopaedics, The National Centre for the Treatment of Pelvic and Acetabular Fractures, The Adelaide and Meath Hospital Dublin, Incorporating The National Children's Hospital (AMNCH), Tallaght, Dublin 24, Ireland. robpiggott1@gmail.com.
authors.forename: R P
authors.initials: RP
authors.lastname: Piggott
authors.affiliation: Department of Trauma and Orthopaedics, The National Centre for the Treatment of Pelvic and Acetabular Fractures, The Adelaide and Meath Hospital Dublin, Incorporating The National Children's Hospital (AMNCH), Tallaght, Dublin 24, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Leonard
mesh_terms: D000077:Acetabulum / Q000293:injuries; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D016063:Blood Loss, Surgical; D050723:Fractures, Bone / Q000601:surgery*; D006801:Humans; D061646:Operative Time; D019637:Orthopedic Procedures / Q000379:methods*
chemical_list: D000933:Antifibrinolytic Agents
keywords: Antifibrinolytics; Blood conserving strategy; Pelvic and acetabular fracture; Tranexamic acid