title: [Blastic plasmacytoid dendritic cell neoplasm: two case reports].
abstract: Blastic plasmacytoid dendritic cell neoplasm (LPDC) is a rare and aggressive leukemia entity with cutaneous and extracutaneous involvement, reaching most often lymph, blood and bone marrow. Two cases of LPDC diagnosed in Hospital Center of Le Mans are reported, a 78 year old woman (case 1) and a 82 year old man (case 2), and have been clinically, biologically and histologically documented. The clinical presentation, diagnostic difficulties are reminded, as well as the pathogenesis and therapeutic aspect.
authors.affiliation: Laboratoire d'hématologie, Centre hospitalier du Mans, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Kaabar
authors.affiliation: Laboratoire d'hématologie, Centre hospitalier du Mans, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lemaire
authors.affiliation: Laboratoire d'hématologie, Centre hospitalier du Mans, France.
authors.forename: Kamel
authors.initials: K
authors.lastname: Laribi
authors.affiliation: Laboratoire d'anatomocytopathologie, Centre hospitalier du Mans, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Sandrini
authors.affiliation: Laboratoire d'hématologie, Centre hospitalier du Mans, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Pineau-Vincent
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003713:Dendritic Cells / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000473:pathology; D008297:Male; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology
keywords: 5-azacytidine; leukemia; plasmocytoid dendritic cell