title: Tools of gene transfer applied to the intracellular delivery of non-nucleic acid polyanionic drugs.
abstract: We report the first successful implementation of transfection agents to facilitate the delivery of non-nucleic acid based anti-inflammatory and anti-viral drugs. In doing so, we illustrate a new paradigm in the intracellular delivery of polyanionic drugs and also extend the scope and utility of successful tools of gene transfer into a new area of biomedical research.
authors.affiliation: Department of Chemistry, Aarhus University, Aarhus, Denmark. Zelikin@chem.au.dk and iNano Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Mille B L
authors.initials: MB
authors.lastname: Kryger
authors.affiliation: Department of Chemistry, Aarhus University, Aarhus, Denmark. Zelikin@chem.au.dk and iNano Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Søren L
authors.initials: SL
authors.lastname: Pedersen
authors.affiliation: Department of Chemistry, Aarhus University, Aarhus, Denmark. Zelikin@chem.au.dk and iNano Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Wohl
authors.affiliation: Department of Chemistry, Aarhus University, Aarhus, Denmark. Zelikin@chem.au.dk and iNano Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zelikin
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems / Q000379:methods*; D018014:Gene Transfer Techniques; D006801:Humans; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D012254:Ribavirin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D014162:Transfection
chemical_list: D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D012254:Ribavirin; C006903:carbopol 940