title: Beclomethasone dipropionate hydrofluoroalkane for the treatment of allergic rhinitis.
abstract: Allergic rhinitis (AR) is a common respiratory disease, and its prevalence is increasing all over the world, both in adults and in children. Patients experience symptoms that may negatively impact on physical, social and psychological well-being. Hence, if left untreated, allergic rhinitis may significantly affect quality of life. Under current guidelines, intranasal corticosteroids are considered the most effective drugs and they are recommended as first-line therapy. Among the several corticosteroid intranasal sprays available, beclomethasone dipropionate is one of the most prescribed. Recently, new intranasal hydrofluoroalkane-propelled formulations with little or no impact on the ozone layer have been developed for the treatment of AR. The use of these devices might improve patients' adherence to treatment, avoiding some of the most common side effects associated with aqueous formulations. This review provides the most recent evidence for the efficacy and safety of beclomethasone dipropionate hydrofluoroalkane nasal aerosol in the treatment of allergic rhinitis.
authors.affiliation: a Department of Science for Health Promotion and Mother and Child Care , University of Palermo , Palermo , Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Ferrante
authors.affiliation: b National Research Council CNR , Institute of Biomedicine and Molecular Immunology IBIM , Palermo , Italy.|c Department of Psychology , University of Palermo , Palermo , Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Montalbano
authors.affiliation: b National Research Council CNR , Institute of Biomedicine and Molecular Immunology IBIM , Palermo , Italy.|d Department of Economics, Business, and Statistics , University of Palermo , Palermo , Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Cilluffo
authors.affiliation: b National Research Council CNR , Institute of Biomedicine and Molecular Immunology IBIM , Palermo , Italy.
authors.forename: Velia
authors.initials: V
authors.lastname: Malizia
authors.affiliation: e Istituto di Biomedicina e Immunologia Molecolare (IBIM) Consiglio Nazionale delle Ricerche (CNR) Palermo , Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Marchese
authors.affiliation: b National Research Council CNR , Institute of Biomedicine and Molecular Immunology IBIM , Palermo , Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: La Grutta
mesh_terms: D000328:Adult; D000335:Aerosol Propellants / Q000627:therapeutic use*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001507:Beclomethasone / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000627:therapeutic use*; D055118:Medication Adherence; D059085:Nasal Sprays; D011788:Quality of Life; D065631:Rhinitis, Allergic / Q000188:drug therapy*; D005466:Fluorocarbons
chemical_list: D000335:Aerosol Propellants; D018927:Anti-Asthmatic Agents; D001507:Beclomethasone; D006845:Hydrocarbons, Fluorinated; D059085:Nasal Sprays; C094049:apaflurane; D005466:Fluorocarbons
keywords: Beclomethasone dipropionate hydrofluoroalkane; allergic rhinitis; asthma; inflammation; intranasal corticosteroids; nasal aerosol; nasal spray