title: Three-Dimensional BC/PEDOT Composite Nanofibers with High Performance for Electrode-Cell Interface.
abstract: There is an increasing need to synthesize biocompatible nanofibers with excellent mechanical and electrical performance for electrochemical and biomedical applications. Here we report a facile approach to prepare electroactive and flexible 3D nanostructured biomaterials with high performance based on bacterial cellulose (BC) nanofibers. Our approach can coat BC nanofibers with poly(3,4-ethylenedioxythiophene) (PEDOT) by in situ interfacial polymerization in a controllable manner. The PEDOT coating thickness is adjustable by the monomer concentration or reaction time during polymerization, producing nanofibers with a total diameter ranging from 30 to 200 nm. This fabrication process also provides a convenient method to tune different parameters such as the average pore size and electrical conductivity on the demands of actual applications. Our experiments have demonstrated that the 3D BC/PEDOT nanofibers exhibit high specific surface area, excellent mechanical properties, electroactive stability, and low cell cytotoxicity. With electrical stimulation, calcium imaging of PC12 neural cells on BC/PEDOT nanofibers has revealed a significant increase in the percentage of cells with higher action potentials, suggesting an enhanced capacitance effect of charge injection. As an attractive solution to the challenge of designing better electrode-cell interfaces, 3D BC/PEDOT nanofibers promise many important applications such as biosensing devices, smart drug delivery systems, and implantable electrodes for tissue engineering.
authors.forename: Chuntao
authors.initials: C
authors.lastname: Chen
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University , 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu Province 215123, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University , 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu Province 215123, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhangqi
authors.initials: Z
authors.lastname: Feng
authors.forename: Chunlin
authors.initials: C
authors.lastname: Zhu
authors.forename: Yalin
authors.initials: Y
authors.lastname: Yu
authors.forename: Kangming
authors.initials: K
authors.lastname: Li
authors.forename: Mengyao
authors.initials: M
authors.lastname: Zhao
authors.forename: Jiazhi
authors.initials: J
authors.lastname: Yang
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University , 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu Province 215123, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Dongping
authors.initials: D
authors.lastname: Sun
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry*; D002482:Cellulose / Q000138:chemical synthesis / Q000737:chemistry*; D004566:Electrodes; D057139:Nanofibers / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene); D002482:Cellulose
keywords: bacterial cellulose; biocompatible; electroactive; electrode-cell interface; three-dimensional nanofibers