title: Chronic Stress Facilitates the Development of Deep Venous Thrombosis.
abstract: The increasing pressure of modern social life intensifies the impact of stress on the development of cardiovascular diseases, which include deep venous thrombosis (DVT). Renal sympathetic denervation has been applied as one of the clinical approaches for the treatment of drug-resistant hypertension. In addition, the close relationship between oxidative stress and cardiovascular diseases has been well documented. The present study is designed to explore the mechanism by which the renal sympathetic nerve system and the oxidative stress affect the blood coagulation system in the development of DVT. Chronic foot shock model in rats was applied to mimic a state of physiological stress similar to humans. Our results showed that chronic foot shock procedure could promote DVT which may be through the activation of platelets aggregation. The aggravation of DVT and activation of platelets were alleviated by renal sympathetic denervation or antioxidant (Tempol) treatment. Concurrently, the denervation treatment could also reduce the levels of circulating oxidation factors in rats. These results demonstrate that both the renal sympathetic nerve system and the oxidative stress contribute to the development of DVT in response to chronic stress, which may provide novel strategy for treatment of clinic DVT patients.
authors.affiliation: Department of Physiology, Medical College of Soochow University, Suzhou 215003, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Dong
authors.affiliation: Department of Physiology, Medical College of Soochow University, Suzhou 215003, China.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Cheng
authors.affiliation: Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, MOH Key Lab of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou 215003, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Physiology, Medical College of Soochow University, Suzhou 215003, China.
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Sun
authors.affiliation: Department of Physiology, Medical College of Soochow University, Suzhou 215003, China.
authors.forename: Chen-Jie
authors.initials: CJ
authors.lastname: Zhu
authors.affiliation: Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, MOH Key Lab of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou 215003, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Physiology, Medical College of Soochow University, Suzhou 215003, China.
authors.forename: Guo-Xing
authors.initials: GX
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D003497:Cyclic N-Oxides / Q000494:pharmacology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005979:Glutathione Peroxidase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation; D011517:Prothrombin Time; D051381:Rats; D017207:Rats, Sprague-Dawley; D013113:Spin Labels; D013312:Stress, Physiological; D013482:Superoxide Dismutase / Q000097:blood; D020246:Venous Thrombosis / Q000209:etiology* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D003497:Cyclic N-Oxides; D013113:Spin Labels; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C001803:tempol; D003345:Corticosterone; D009638:Norepinephrine