title: Bony Regeneration of the Sella after Transsphenoidal Pituitary Surgery.
abstract: OBJECTIVE
  The purpose of this study is to demonstrate the possible bony regrowth of the sella after transsphenoidal surgery without any intraoperative sellar reconstruction.
  
  
  METHODS
  Radiologic findings of the sella were reviewed in patients with pituitary tumors treated by transsphenoidal surgery. In 17 patients who had postoperative cranial computed tomography scans, bony regeneration of the sellar floor was evaluated by comparing immediate and late postoperative scans. The bony opening reduction was measured in transverse and sagittal planes.
  
  
  RESULTS
  The median bony opening diameter in the transverse plane was 8.8 mm (interquartile range [IQR] 5.7-11.4) on the first scan and 4.2 mm (IQR 0.8-6.8) on the second scan. In the sagittal plane, it was 4.8 mm (IQR 1.8-6.8) on the first scan and 2.9 mm (IQR 1.6-3.9) on the second scan. These changes occurred in a median time of 36 months (IQR 22-42). There was a statistically significant decrease of the bony opening diameters in both the transverse and sagittal planes (P < 0.0001 and P = 0.0004, respectively). Bone regeneration was observed in 16 of the 17 patients (approximately 94%).
  
  
  CONCLUSIONS
  There is a natural bony regeneration of the sella after transsphenoidal pituitary surgery.
authors.affiliation: Department of Neurosurgery, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: mehdiyc@gmail.com.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yahia-Cherif
authors.affiliation: Department of Neuroradiology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Delpierre
authors.affiliation: Department of Otorhinolaryngology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Sergio
authors.initials: S
authors.lastname: Hassid
authors.affiliation: Department of Neurosurgery, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Olivier
authors.initials: O
authors.lastname: De Witte
mesh_terms: D000328:Adult; D000368:Aged; D001861:Bone Regeneration; D005260:Female; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D044583:Neuroendoscopy / Q000379:methods*; D010902:Pituitary Gland / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011859:Radiography; D012189:Retrospective Studies; D012658:Sella Turcica / Q000000981:diagnostic imaging* / Q000254:growth & development*; D013100:Sphenoid Bone / Q000473:pathology / Q000601:surgery
keywords: Bone regeneration; Reoperation; Sella turcica; Transsphenoidal surgery