title: Association between single nucleotide polymorphisms of the G-protein γ5 subunit and the risk of essential hypertension in the population of Poland.
abstract: BACKGROUND
  Polymorphisms in genes coding G-protein subunits (α, β, and γ) may affect the response of stimulated α2A-adrenergic receptors, which are involved in the regulation of blood pressure. OBJECTIVES The aim of the present study was to determine the association between the rs11559300 (A/G), rs199705300 (C/A), rs61754630 (C/T), rs13093 (C/A), and rs41284589 (C/T) single nucleotide polymorphisms (SNPs) of the gene coding G-protein γ5 subunit (GNG5) and the risk of essential hypertension in the population of Poland.
  
  
  METHODS
  A total number of 838 subjects were included in the study: 536 patients with diagnosed essential hypertension and 302 controls. Genotyping was performed using the polymerase chain reaction-restriction length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  Of the studied GNG5 polymorphisms, only SNP rs13093 was significantly associated with an increased risk of essential hypertension (odds ratio [OR], 2.91; 95% confidence interval [CI], 1.68-5.05; P = 0.0036). In addition, the T allele of rs41284589 may protect against hypertriglyceridemia (OR, 0.32; 95% CI, 0.1-0.9).
  
  
  CONCLUSIONS
  rs13093 in the promoter region of GNG5 may be associated with an increased risk of essential hypertension in the Polish population. Further studies are needed to explain the molecular mechanism by which rs13093 affects blood pressure.
authors.forename: Paulina
authors.initials: P
authors.lastname: Hejduk
authors.forename: Agata M
authors.initials: AM
authors.lastname: Sakowicz
authors.forename: Melania
authors.initials: M
authors.lastname: Mikołajczyk
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Śliwińska
authors.forename: Józef
authors.initials: J
authors.lastname: Drzewoski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Pietrucha
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000075222:Essential Hypertension; D005260:Female; D044388:GTP-Binding Protein gamma Subunits / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: C000614654:GNG5 protein, human; D044388:GTP-Binding Protein gamma Subunits