title: Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases.
abstract: After the recent description of the human genome by the ENCODE and the FANTOM consortia, major attention has been addressed to the so-called "genomic noise", which mainly consists of noncoding RNAs (ncRNAs). Among them, microRNAs and long non-coding RNAs have been demonstrated to modulate gene expression and to be involved in several human diseases. Since ncRNAs and their targets are encoded in the genome, genetic principles apply. Common variants are supposed to influence the expression level and the functionality of ncRNAs, with subsequent differential regulation of their target genes. Moreover, several reports showed that polymorphisms in ncRNA or their target genes play a role in the development of cardiovascular adverse phenotype. Here, we provide an overview of the effects of these variations in cardiovascular diseases.
authors.affiliation: Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands.
authors.forename: Martina
authors.initials: M
authors.lastname: Calore
authors.affiliation: Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands.
authors.forename: Leon J
authors.initials: LJ
authors.lastname: De Windt
authors.affiliation: Department of Biology, University of Padua, Via G. Colombo 3, 35131, Padua, Italy. Electronic address: alessandra.rampazzo@unipd.it.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rampazzo
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics*; D044127:Epigenesis, Genetic; D014644:Genetic Variation; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism
chemical_list: D022661:RNA, Untranslated
keywords: Cardiovascular diseases; Common genetic variants; Long noncoding RNAs; MiRNAs