title: Haemophagocytic lymphohistiocytosis in inflammatory bowel disease with virus infection.
abstract: Patients with inflammatory bowel disease (IBD) are at risk of developing haemophagocytic lymphohistiocytosis (HLH) because of chronic systemic inflammation as well as exposure to immunosuppressive medications. The two main causes of HLH in IBD patients are infection with cytomegalovirus and Epstein-Barr virus. Patients with Crohn's disease are more susceptible to HLH than those with ulcerative colitis. The majority of cases are seen in people receiving an immunosuppressive regimen that included thiopurines.
authors.affiliation: Department of Gastroenterology, The Third Hospital of Peking University, Beijing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Methodist Hospital Research Institute, Weill Cornell School of Medicine, Houston, TX, USA.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Xia
authors.affiliation: Department of Gastroenterology, The Third Hospital of Peking University, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, The Third Hospital of Peking University, Beijing, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Gastroenterology, The Third Hospital of Peking University, Beijing, China.
authors.forename: Liya
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Gastroenterology, The Third Hospital of Peking University, Beijing, China.
authors.forename: Yaopeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, The Third Hospital of Peking University, Beijing, China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Gastroenterology, The Third Hospital of Peking University, Beijing, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Methodist Hospital Research Institute, Weill Cornell School of Medicine, Houston, TX, USA.
authors.forename: Eamonn M M
authors.initials: EM
authors.lastname: Quigley
authors.affiliation: Department of Gastroenterology, The Third Hospital of Peking University, Beijing, China.
authors.forename: Shigang
authors.initials: S
authors.lastname: Ding
keywords: Epstein-Barr virus; cytomegalovirus; haemophagocytic lymphohistiocytosis; inflammatory bowel disease; thiopurines