title: Leptin receptor gene polymorphisms and risk of hypertension: a meta-analysis.
abstract: OBJECTIVE
  To assess the relationship between the polymorphisms of leptin receptor gene and hypertension.
  
  
  METHODS
  Meta analysis was conducted by using RevMan 5.3. Relevant literatures were retrieved by searching PubMed using the keywords "Hypertension", "Leptin Receptor", "OB Receptor", "LEPR Protein".
  
  
  RESULTS
  Fifteen studies with a total of 5955 patients with hypertension and 3830 healthy controls were included in this meta-analysis. The results showed that Gln223Arg gene polymorphism was significantly higher in hypertension patients than in control (OR=1.36, 95% CI=1.23-1.51, P<0.00001). However, no statistically significant difference was found in Lys109Arg polymorphism between hypertension patients and control (OR=0.99, 95% CI=0.85-1.16, P=0.91).
  
  
  CONCLUSIONS
  Gln223Arg, but not Lys109Arg gene polymorphism, is higher in hypertension patients, suggesting that patients with Gln223Arg allele carry a higher risk to develop hypertension.
authors.affiliation: Department of Emergency, Jining First People's Hospital China.
authors.forename: Yingdong
authors.initials: Y
authors.lastname: Lian
authors.affiliation: Department of Orthopedics Rehabilitation and Reconstruction, Linyi People's Hospital China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Tang
authors.affiliation: ICU, Hebei United University Affiliated Hospital China.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Emergency, Jining First People's Hospital China.
authors.forename: Zongxiang
authors.initials: Z
authors.lastname: Chen
keywords: Hypertension; gene polymorphism; leptin receptor; meta-analysis; risk