title: Antibacterial and antiplaque efficacy of a commercially available octenidine-containing mouthrinse.
abstract: OBJECTIVE
  The purpose of this clinical study was to determine the antibacterial and antiplaque efficacy of a recently introduced octenidine-containing mouthrinse (Octenidol®) in comparison with established antiseptic mouthrinses.
  
  
  METHODS
  In a 4-day plaque-regrowth study employing a four-replicate cross-over design, a 0.1 % octenidine mouthrinse (Octenidol®/OCT-MR) was compared with a 0.12 % chlorhexidine mouthrinse (Paroex®/CHX-MR), an essential oil mouthrinse (Listerine®/EO-MR), and a placebo mouthrinse/P-MR. Plaque regrowth was assessed with a modified Quigley-Hein plaque index. The antibacterial effect was assessed by taking bacterial counts from the tooth surface and oral mucosa after professional tooth cleaning and after first rinsing with the allocated mouthrinse on days 1 and 5. Sixteen volunteers suspended tooth cleaning and rinsed twice daily with the allocated mouthrinse for 4 days.
  
  
  RESULTS
  All tested antiseptic mouthrinses were significantly more effective than the placebo mouthrinse in inhibiting plaque, but no significant differences were observed between OCT-MR and CHX-MR, OCT-MR and EO-MR, and CHX-MR and EO-MR. After 4 days, comparable bacterial count levels were found on both the tooth surface and mucosa applying OCT-MR and CHX-MR, which were significantly lower than that of EO-MR and P-MR.
  
  
  CONCLUSIONS
  Octenidol® and Paroex® showed comparable antibacterial and antiplaque efficacy in the human oral cavity.
  
  
  CONCLUSIONS
  The recently introduced octenidine-containing mouthrinse Octenidol® may become a suitable alternative to 0.12 % chlorhexidine-containing mouthrinses such as Paroex®.
authors.affiliation: Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental School, University Medicine Greifswald, Walther-Rathenau-Str. 42a, 17475, Greifswald, Germany. welk@uni-greifswald.de.
authors.forename: Alexander
authors.initials: A
authors.lastname: Welk
authors.affiliation: Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental School, University Medicine Greifswald, Walther-Rathenau-Str. 42a, 17475, Greifswald, Germany.
authors.forename: Maral
authors.initials: M
authors.lastname: Zahedani
authors.affiliation: Private Practice, Schwerin, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Beyer
authors.affiliation: Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Kramer
authors.affiliation: Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Gerald
authors.initials: G
authors.lastname: Müller
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007097:Imines; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use; D013729:Terpenes / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D007097:Imines; D009067:Mouthwashes; D011725:Pyridines; D012459:Salicylates; D013729:Terpenes; C057473:Listerine; C034213:octenidine; D002710:Chlorhexidine
keywords: Antiseptic; Chlorhexidine; Dental plaque; Essential oil; Mouthrinses; Octenidine