title: Non-infectious cholecystopathy secondary to high-dose IL-2 cancer immunotherapy.
abstract: Interleukin-2 (IL-2) associated cholecystopathy is a rare manifestation of IL-2 drug toxicity in the setting of cancer immunotherapy. While the imaging data and clinical presentation can easily mimic acute cholecystitis, the correct diagnosis can be made with the particular clinical history, thus avoiding inappropriate surgical management. As more cancer immunotherapies become standard oncologic treatments, specific immunotherapy-associated side effects are also expected to be encountered more frequently in the future and should be recognized as such. We present a case of IL-2-associated cholecystopathy in the setting of renal cell carcinoma immunotherapy.
authors.affiliation: University of South Florida College of Medicine, Department of Radiology, Tampa, Florida, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Kuppler
authors.affiliation: H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Jeong
authors.affiliation: H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
authors.forename: Jung W
authors.initials: JW
authors.lastname: Choi
keywords: Abdomen/GI; biliary; drugs/reactions; gallbladder; neoplasms – primary; ultrasound