title: The Role of Systemic Arterial Stiffness in Open-Angle Glaucoma with Diabetes Mellitus.
abstract: To investigate the role of systemic arterial stiffness in glaucoma patients with diabetes mellitus (DM).
  
  
  
  Retrospective, cross-sectional study.
  
  
  
  DM subjects who underwent brachial-ankle pulse wave velocity (baPWV) were recruited.
  
  
  
  Glaucoma patients (n = 75) and age-matched control subjects (n = 92) were enrolled. Systemic examination including BaPWV and detailed eye examination were performed. The glaucoma group was divided into subgroups of normal tension glaucoma (NTG, n = 55) and primary open-angle glaucoma (POAG) based on an IOP of 21 mmHg. BaPWV was used to stratify the population into 4 groups based on the rate. Stepwise multiple logistic regression analysis by baPWV quartiles was used to compare the glaucoma group with the control group.
  
  
  
  BaPWV in glaucoma with DM patients.
  
  
  
  Faster baPWV was positively associated with glaucoma (odds ratio: 3.74; 95% CI: 1.03-13.56, stepwise multiple logistic regression analysis) in patients with DM. Increasing baPWV was also positively associated with glaucoma (p for trend = 0.036). The NTG subgroup showed similar results to those of the glaucoma group.
  
  
  
  In this study, increased arterial stiffness was shown to be associated with glaucoma and may contribute to the pathogenesis of glaucoma in DM patients.
authors.affiliation: Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea.
authors.forename: Seong Hee
authors.initials: SH
authors.lastname: Shim
authors.affiliation: Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Chan Yun
authors.initials: CY
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea.
authors.forename: Joon Mo
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea.
authors.forename: Da Yeong
authors.initials: DY
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea.
authors.forename: Yang Jae
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea.
authors.forename: Jeong Hun
authors.initials: JH
authors.lastname: Bae
authors.affiliation: Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Republic of Korea.
authors.forename: Ki Chul
authors.initials: KC
authors.lastname: Sung
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index / Q000379:methods; D001158:Arteries / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011673:Pulsatile Flow / Q000502:physiology; D063177:Pulse Wave Analysis / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*