title: Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity.
abstract: Severe cold agglutinin disease with hemodynamic compromise requires rapid stabilization of the autoimmune hemolytic anemia as a bridge to the immunosuppressive effect of rituximab. Herein, we describe eculizumab treatment of severe complement-mediated hemolysis in a patient whose hemodynamic status deteriorated in spite of supportive blood transfusions and therapeutic plasma exchange.
authors.affiliation: Department of Medicine, London Health Science Centre, Western University London, Ontario.
authors.forename: Roman
authors.initials: R
authors.lastname: Shapiro
authors.affiliation: Division of Hematology, London Health Science Centre, Western University London, Ontario.
authors.forename: Ian
authors.initials: I
authors.lastname: Chin-Yee
authors.affiliation: Division of Hematology, London Health Science Centre, Western University London, Ontario.
authors.forename: Selay
authors.initials: S
authors.lastname: Lam
keywords: Anti-Pr; cold autoimmune hemolytic anemia; eculizumab; rituximab