title: Adjuvant Radiotherapy with Three-Dimensional Conformal Radiotherapy of Lacrimal Gland Adenoid Cystic Carcinoma.
abstract: OBJECTIVE
  Adenoid cystic carcinoma (ACC) of lacrimal gland is a rare tumour with aggressive behaviour. There is sparse data to address optimum therapy for such tumours. So, the present study was aimed at evaluating the role of adjuvant three dimensional conformal radiotherapy (3D-CRT) in cases of incomplete (R1) resection along with review of literature pertaining to management of lacrimal adenoid cystic carcinoma.
  
  
  METHODS
  We retrospectively reviewed the demographic and treatment data of 10 biopsy proven ACC of lacrimal gland patients, treated from December 2006 to June 2013. They were treated with radiotherapy following surgical resection. Eight patients underwent gross total excision of the tumour mass (enbloc excision) followed by conformal radiotherapy to a dose of 60 Gray/30fractions/ 6 weeks. Two patients with advanced disease were treated with palliative radiotherapy after biopsy.
  
  
  RESULTS
  The median age was 32 years. There were equal numbers of male and female patients. The median duration of symptoms was 7 months. At a median follow up of 21 months, eight patients had no evidence of disease and had complete tumour response, two patients worsened, and one of the two had systemic failure with bone metastasis.
  
  
  CONCLUSIONS
  Despite a small sample size and short follow, enbloc surgical excision with adjuvant radiotherapy is well tolerated and shows good control in ACC of lacrimal gland.
authors.affiliation: Clinical Associate, Department of Radiation Oncology, Fortis Memorial Research Institute , Gurgaon, India .
authors.forename: Vikas
authors.initials: V
authors.lastname: Roshan
authors.affiliation: Additional Professor, Department of Radiation Oncology, Dr BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Sushmita
authors.initials: S
authors.lastname: Pathy
authors.affiliation: Senior Research Associate, Department of Radiation Oncology, Dr BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Supriya
authors.initials: S
authors.lastname: Mallick
authors.affiliation: Professor, Department of Radiation Oncology, Dr BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Subhash
authors.initials: S
authors.lastname: Chander
authors.affiliation: Professor, Department of Ocular Pathology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Seema
authors.initials: S
authors.lastname: Sen
authors.affiliation: Additional Professor, Oncology Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Bhavna
authors.initials: B
authors.lastname: Chawla
keywords: Orbital tumours; Radiation; Surgical excision