title: [Risk factors of progressive brain contusion and relationship with outcome].
abstract: To investigate the risk factors of progressive brain contusion and to evaluate their impact on patients' outcome.
  
  
  
  One hundred and thirty two patients with traumatic brain contusion were enrolled in the study, including 70 cases with progressive contusion and 62 cases with non-progressive contusion. The risk factors were investigated with univariate and multivariate Logistic regression analysis.
  
  
  
  The univariate analysis showed that Glasgow Coma Score (GCS) at admission, contusion volume at the first brain CT scans, midline shift, combined with skull fracture, subarachnoid hemorrhage, epidural hematoma, subdural hematoma, location of brain contusion, D-dimer levels, combined with type 2 diabetes were associated with progressive brain contusion. Multivariate Logistic regression analysis showed that GCS at admission, contusion volume at the first CT scans, combined with subarachnoid hemorrhage, combined with type 2 diabetes were the independent risk factors for disease progression. The outcome in the progressive group was more aggravated than that in non-progressive group (P = 0.001).
  
  
  
  Patients with disturbance of consciousness, the larger contusion volume, combined with subarachnoid hemorrhage and diabetes are at risk for progressive brain contusion and unfavorable outcome.
authors.affiliation: Department of Neurosurgery, Zhejiang Xiaoshan Hospital, Hangzhou 311201, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Zhejiang Xiaoshan Hospital, Hangzhou 311201, China.
authors.forename: Dong-qing
authors.initials: DQ
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Zhejiang Xiaoshan Hospital, Hangzhou 311201, China.
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Zhejiang Xiaoshan Hospital, Hangzhou 311201, China.
authors.forename: Yu-jian
authors.initials: YJ
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Zhejiang Xiaoshan Hospital, Hangzhou 311201, China.
authors.forename: Hai-dong
authors.initials: HD
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Zhejiang Xiaoshan Hospital, Hangzhou 311201, China.
authors.forename: Zhang-feng
authors.initials: ZF
authors.lastname: Shen
authors.affiliation: Department of Neurosurgery, Zhejiang Xiaoshan Hospital, Hangzhou 311201, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Neurosurgery, Zhejiang Xiaoshan Hospital, Hangzhou 311201, China.
authors.forename: Hai-bin
authors.initials: HB
authors.lastname: Wu
mesh_terms: D001930:Brain Injuries / Q000150:complications* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D018450:Disease Progression; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D015600:Glasgow Coma Scale; D006407:Hematoma, Epidural, Cranial / Q000150:complications; D006408:Hematoma, Subdural / Q000150:complications; D006801:Humans; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000150:complications; D014057:Tomography, X-Ray Computed
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D