title: Managing Hypertension in Patients with CKD: A Marathon, Not a SPRINT.
abstract: In this manuscript, nephrologist-investigators from one of five Clinical Center Networks of the Systolic Blood Pressure Intervention Trial (SPRINT) provide background information and context on the intensity of anti-hypertensive therapy in conjunction with the release of detailed results from SPRINT's primary analysis. The authors highlight published evidence on the safety and efficacy of differing intensities of anti-hypertensive therapy in mild to moderate CKD, where SPRINT will help to inform practice, as well as where gaps in evidence will remain. The authors also challenge the nephrology community to renew its attention and efforts on hypertension clinical care and research.
authors.affiliation: Division of Nephrology, Department of Medicine, Stanford University, Stanford, California; gchertow@stanford.edu.
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Chertow
authors.affiliation: Division of Nephrology, Internal Medicine School of Medicine, University of Utah, Salt Lake City, Utah;
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Beddhu
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University, Nashville, Tennessee; and.
authors.forename: Julia B
authors.initials: JB
authors.lastname: Lewis
authors.affiliation: Department of Clinical Science, University of Texas Southwestern, Dallas, Texas.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Toto
authors.affiliation: Division of Nephrology, Internal Medicine School of Medicine, University of Utah, Salt Lake City, Utah;
authors.forename: Alfred K
authors.initials: AK
authors.lastname: Cheung
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy*; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012720:Severity of Illness Index
chemical_list: D000959:Antihypertensive Agents
keywords: chronic kidney disease; clinical trial; hypertension