title: Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis.
abstract: Treatment of multidrug-resistant Mycobacterium tuberculosis is a challenge. This letter describes the emergence of resistance to new therapies, bedaquiline and delamanid.
authors.affiliation: University of Zurich, Zurich, Switzerland.
authors.forename: Guido V
authors.initials: GV
authors.lastname: Bloemberg
authors.forename: Peter M
authors.initials: PM
authors.lastname: Keller
authors.forename: David
authors.initials: D
authors.lastname: Stucki
authors.forename: David
authors.initials: D
authors.lastname: Stuckia
authors.forename: Andrej
authors.initials: A
authors.lastname: Trauner
authors.forename: Sonia
authors.initials: S
authors.lastname: Borrell
authors.forename: Tsogyal
authors.initials: T
authors.lastname: Latshang
authors.forename: Mireia
authors.initials: M
authors.lastname: Coscolla
authors.forename: Thomas
authors.initials: T
authors.lastname: Rothe
authors.forename: Rico
authors.initials: R
authors.lastname: Hömke
authors.forename: Claudia
authors.initials: C
authors.lastname: Ritter
authors.forename: Julia
authors.initials: J
authors.lastname: Feldmann
authors.forename: Bettina
authors.initials: B
authors.lastname: Schulthess
authors.forename: Sebastien
authors.initials: S
authors.lastname: Gagneux
authors.forename: Erik C
authors.initials: EC
authors.lastname: Böttger
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D064687:Diarylquinolines / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D010080:Oxazoles / Q000627:therapeutic use*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D064687:Diarylquinolines; D009593:Nitroimidazoles; C516022:OPC-67683; D010080:Oxazoles; C493870:bedaquiline