title: A2 /A2 B to B Renal Transplantation: Past, Present, and Future Directions.
abstract: One component of the new national kidney allocation system (KAS) in the United States that was implemented on December 4, 2014, was the allocation of kidneys from A2 and A2 B (A, non-A1 and AB, non-A1 B) deceased donors into blood group B candidates (A2 /A2 B → B). In so far as this is an important component of the new KAS that has the potential to further increase the access to transplantation for blood group B candidates on the waiting list, most of whom are minority candidates, we will review the body of evidence and historical perspectives that led to its inclusion in the new KAS. This review will also describe prospects for more widespread use of A2 /A2 B → B transplantation and a novel mechanism of humoral immunosuppression in B patients before and after transplantation with an A2 or A2 B kidney.
authors.affiliation: Midwest Transplant Network, Westwood, KS.
authors.forename: C F
authors.initials: CF
authors.lastname: Bryan
authors.affiliation: United Network for Organ Sharing, Richmond, VA.
authors.forename: W S
authors.initials: WS
authors.lastname: Cherikh
authors.affiliation: Childrens Hospital of Philadelphia, Philadelphia, PA.
authors.forename: D A
authors.initials: DA
authors.lastname: Sesok-Pizzini
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D040841:Resource Allocation; D014019:Tissue Donors; D009927:Tissue and Organ Procurement
chemical_list: D000017:ABO Blood-Group System
keywords: ABO incompatibility; Organ Procurement and Transplantation Network (OPTN); clinical research/practice; donors and donation: deceased; kidney (allograft) function/dysfunction; kidney transplantation/nephrology; organ allocation