title: To assess the association between vertebral marrow fat content and colorectal adenoma in postmenopausal women using magnetic resonance spectroscopy.
abstract: BACKGROUND
  Although lower bone mineral density (BMD) is considered to have an increased risk for colorectal adenoma, no association between marrow fat content and colorectal adenoma has been elucidated yet.
  
  
  OBJECTIVE
  To evaluate the relationship between marrow fat fraction (MFF) and the presence of colorectal adenoma in postmenopausal women using magnetic resonance spectroscopy (MRS).
  
  
  METHODS
  We performed a cross-sectional observational study on 152 postmenopausal patients with colorectal adenoma and 100 matched control subjects who underwent screening colonoscopy, biochemical measurements, dual-energy X-ray absorptiometry, and MRS. Logistic regression models were performed to assess the relationships among BMD, MFF, and colorectal adenoma.
  
  
  RESULTS
  With univariate analysis, marrow fat accumulation was higher and BMD values were lower in patients with colorectal adenoma compared with those in controls. After adjustment for potential confounders including demographics, health history, blood lipid levels, indexes of glucose metabolism, and validated measures of diet and physical activity, MFF was significantly positively associated with colorectal adenoma (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.10-2.46; P = 0.008). Vertebral BMD, but not total hip and femoral neck BMD, was inversely related with colorectal adenoma (OR, 0.62; 95% CI, 0.14-0.89; P = 0.027). Additionally, MFF was associated with adenoma number, size, and high-risk adenoma (all P < 0.01). MFF was found to be an independent risk factor of a high-risk colorectal adenoma (OR, 2.08; 95% CI, 1.24-3.60; P = 0.019).
  
  
  CONCLUSIONS
  Marrow fat accumulation is highly associated with colorectal adenoma, particularly high-risk adenoma, in postmenopausal women.
authors.affiliation: Department of Radiology, Ningbo Medical Treatment Center Lihuili Hospital, Zhejiang, PR China xuhaidongnb@163.com.
authors.forename: Haidong
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Radiology, Ningbo Medical Treatment Center Lihuili Hospital, Zhejiang, PR China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Ningbo Medical Treatment Center Lihuili Hospital, Zhejiang, PR China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Dong
authors.affiliation: Department of Anus-intestines, Ningbo Medical Treatment Center Lihuili Hospital, Zhejiang, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Pei
authors.affiliation: Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
authors.forename: Guanwu
authors.initials: G
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, PR China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
mesh_terms: D015502:Absorptiometry, Photon; D000236:Adenoma / Q000000981:diagnostic imaging* / Q000473:pathology; D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000473:pathology; D015519:Bone Density; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000473:pathology; D016022:Case-Control Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D017698:Postmenopause; D012307:Risk Factors
keywords: Magnetic resonance spectroscopy (MRS); blood lipid; bone mineral density; colorectal adenoma; marrow fat fraction