title: A pharmacogenomic study revealed an association between SLC6A4 and risperidone-induced weight gain in Chinese Han population.
abstract: OBJECTIVE
  We carried out a pharmacogenomic study in order to identify susceptible genes for antipsychotics induced weight gain within the Chinese Han population.
  
  
  METHODS
  We enrolled 216 patients with schizophrenia in our study. All of them underwent risperidone monotherapy, and fulfilled 4-week follow-up. Weight gain was measured before treatment and 4 weeks later. Seven hundred and sixty-eight SNPs from 85 genes were calculated for association with weight gain percentage.
  
  
  RESULTS
  Fifty-seven SNPs located at 16 genes with a p-value less than 0.05.4 SNPs located on serotonin transporter gene (solute carrier family 6, member 4, SLC6A4) remained significant after multitest correction (rs3813034, p = 0.000357, q = 0.08, rs1042173, rs4325622, rs9303628, p = 0.000451, q = 0.08).
  
  
  CONCLUSIONS
  SLC6A4 might be susceptible gene for risperidone-induced weight gain within the Chinese Han population.
authors.affiliation: Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China.|Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China.|Beijing Children's Hospital, Capital Medical University, Beijing 100191, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China.|Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Mi
authors.affiliation: Jinzhou Kangning Hospital, Jinzhou, Liaoning 121013, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Ma
authors.affiliation: Jinzhou Kangning Hospital, Jinzhou, Liaoning 121013, China.
authors.forename: Cuicui
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Psychiatry of the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China.|Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang, Henan 453002, China.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Psychiatry of the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China.|Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang, Henan 453002, China.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Hebei Mental Health Center, Baoding, Hebei 071000, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Du
authors.affiliation: Hebei Mental Health Center, Baoding, Hebei 071000, China.
authors.forename: Keqing
authors.initials: K
authors.lastname: Li
authors.affiliation: Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China.|Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China.
authors.forename: Chenxing
authors.initials: C
authors.lastname: Liu
authors.affiliation: Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China.|Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China.
authors.forename: Lifang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China.|Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China.
authors.forename: Tianlan
authors.initials: T
authors.lastname: Lu
authors.affiliation: Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China.|Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry of the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China.|Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang, Henan 453002, China.
authors.forename: Luxian
authors.initials: L
authors.lastname: Lv
authors.affiliation: Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China.|Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China.
authors.forename: Dai
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Peking University Sixth Hospital (Institute of Mental Health), Beijing 100191, China.|Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Health (Peking University), Beijing 100191, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Yue
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies / Q000379:methods; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018967:Risperidone / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D015430:Weight Gain / Q000187:drug effects / Q000235:genetics*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D018967:Risperidone
keywords: pharmacogenomic; risperidone-induced weight gain; serotonin transporter gene (solute carrier family 6, member 4, SLC6A4)