title: Small Molecules Take A Big Step Against Clostridium difficile.
abstract: Effective treatment of Clostridium difficile infections demands a shift away from antibiotics towards toxin-neutralizing agents. Work by Bender et al., using a drug that attenuates toxin action in vivo without affecting bacterial survival, demonstrates the exciting potential of small molecules as a new modality in the fight against C. difficile.
authors.affiliation: Molecular Structure & Function, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada.
authors.forename: Greg L
authors.initials: GL
authors.lastname: Beilhartz
authors.affiliation: Molecular Structure & Function, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Tam
authors.affiliation: Molecular Structure & Function, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: roman.melnyk@sickkids.ca.
authors.forename: Roman A
authors.initials: RA
authors.lastname: Melnyk
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000188:drug therapy*; D014774:Virulence / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Clostridium difficile; TcdB; ebselen; inhibitor; small molecule