title: Analysis of the serum reproductive system related autoantibodies of infertility patients in Tianjin region of China.
abstract: OBJECTIVE
  Reproductive system related autoantibodies have been proposed to be associated with natural infertility. However, large scale systematic analysis of these of antibodies has not been conducted. The aim of this study is to analyze the positive rate of antisperm antibody (ASAb), anti-endometrium antibody (EMAb), anti-ovary antibody (AOAb), anti-zona pellucida antibody (AZP) and anticardiolipin antibody (ACA) in infertility patients in Tianjin region of China.
  
  
  METHODS
  1305 male and 1711 female primary infertility patients and 1100 female secondary infertility patients were included in this study, as well as 627 healthy female controls. The above autoantibodies were tested and the positive rates in each group were calculated.
  
  
  RESULTS
  the positive rate of ASAb were significantly higher in primary infertility female than that in male, further analysis revealed that primary infertility population all exhibit significant higher positive rate of EMAb, AOAb, AZP and ACA compared with control group. Furthermore, the positive rates of all the antibodies in primary infertility female were significantly higher than those in secondary infertility female.
  
  
  CONCLUSIONS
  Our study thus indicates that these autoantibodies might be associated with immunological related primary infertility and may have clinical significance in its diagnosis and treatment.
authors.affiliation: Department of Family Planning, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huo
authors.affiliation: Department of Gynecology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
authors.forename: Yanying
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Family Planning, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
authors.forename: Jianmei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gynecology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Urology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Family Planning, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Family Planning, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
authors.forename: Bumei
authors.initials: B
authors.lastname: Zhang
keywords: ACA; AOAb; AZP; EMAb; Immune; autoantibody; infertility