title: Treatment of Aggressive Pelvic Fibromatosis With Interferon.
abstract: BACKGROUND
  Fibromatosis is a rare, noninvasive but aggressive tumor. The tumor displaces tissue by "pushing" the normal structures aside. Optimal treatment should be individualized.
  
  
  METHODS
  A 35-year-old woman presented with a recurrent fibromatosis, which filled the vagina and extended into the pelvis. The classical surgical removal would have had a high morbidity. Therefore, it was decided, after shared decision-making, to opt for treatment with interferon. The side effects of the therapy were tolerable, and a complete regression of the fibromatosis was achieved. At present, 13 years after the diagnosis and 7 years after discontinuation of the therapy, the patient is well with no signs of disease.
  
  
  CONCLUSIONS
  Interferon may be considered as primary treatment for extensive pelvic fibromatosis.
authors.affiliation: Multidisciplinary Breast Clinic, Gynecological Oncology Unit, Department of Obstetrics and Gynecology, and the Department of Radiology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
authors.forename: Femke
authors.initials: F
authors.lastname: Ariën
authors.forename: Jacomijntje M
authors.initials: JM
authors.lastname: Aleman
authors.forename: Bart
authors.initials: B
authors.lastname: Op de Beeck
authors.forename: Wiebren A A
authors.initials: WAA
authors.lastname: Tjalma
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D018221:Fibromatosis, Abdominal / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D010388:Pelvis / Q000473:pathology; D011994:Recombinant Proteins / Q000627:therapeutic use; D014625:Vaginal Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins