title: Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine.
abstract: Exploration of novel chemical space, a modern trend in medicinal chemistry, is heavily reliant on synthetic access to new and interesting building blocks. In this direction, the following work describes an expedient synthesis of one such moiety, 3-fluorobicyclo[1.1.1]pentan-1-amine, by employing radical fluorination.
authors.affiliation: Institute of Chemical and Engineering Sciences (ICES), Agency for Science Technology and Research (A*STAR), 8 Biomedical Grove, Neuros, #07-01, Singapore 138665, Singapore. vikrant_adsool@ices.a-star.edu.sg.
authors.forename: Yi Ling
authors.initials: YL
authors.lastname: Goh
authors.forename: Vikrant A
authors.initials: VA
authors.lastname: Adsool
mesh_terms: D000588:Amines / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D054879:Halogenation; D015394:Molecular Structure
chemical_list: D000588:Amines; D001643:Bridged Bicyclo Compounds; C000588836:bicyclo(1.1.1)pentan-1-amine