title: [Anti remodeling therapy: new strategies and future perspective in post-ischemic heart failure: Part I].
abstract: In recent years, the remarkable progress achieved in terms of survival after myocardial infarction have led to an increased incidence of chronic heart failure in survivors. This phenomenon is due to the still incomplete knowledge we possess about the complex pathophysiological mechanisms that regulate the response of cardiac tissue to ischemic injury. These involve various cell types such as fibroblasts, cells of the immune system, endothelial cells, cardiomyocytes and stem cells, as well as a myriad of mediators belonging to the system of cytokines and not only. In parallel with the latest findings on post-infarct remodeling, new potential therapeutic targets are arising to halt the progression of disease. In this review, we evaluate the results obtained from four new therapeutic strategies: in this part we evaluate gene therapy and novel aspect of stem cells therapy in remodeling; in the second part we will investigate, micro-RNA, posttranslational modification and microspheres based therapy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Sirico
authors.forename: Andrea
authors.initials: A
authors.lastname: Salzano
authors.forename: Dario
authors.initials: D
authors.lastname: Celentani
authors.forename: Michele
authors.initials: M
authors.lastname: Arcopinto
authors.forename: Alberto Maria
authors.initials: AM
authors.lastname: Marra
authors.forename: Emanuele
authors.initials: E
authors.lastname: Bobbio
authors.forename: Angelo
authors.initials: A
authors.lastname: Russo
authors.forename: Francesco
authors.initials: F
authors.lastname: Giallauria
authors.forename: Carlo
authors.initials: C
authors.lastname: Vigorito
mesh_terms: D015316:Genetic Therapy / Q000379:methods*; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D017063:Outcome Assessment, Health Care; D033581:Stem Cell Transplantation / Q000379:methods*; D020257:Ventricular Remodeling / Q000502:physiology*