title: TSPO as a target for glioblastoma therapeutics.
abstract: The translocator protein (TSPO) is an 18-kDa five-transmembrane protein, which is primarily found in the outer mitochondrial membrane. Levels of this protein are up-regulated in the most aggressive and common glioma, glioblastoma multiforme (GM). Levels of TSPO also correlate with GM clinical outcome, suggesting that TSPO may be a novel GM diagnostic imaging agent. Therapeutically, targeting the TSPO may provide a mechanism to abrogate the apoptotic-resistant, invasive and aggressive nature of GM and may also provide a way of targeting other anti-cancer treatments to GM sites. This review highlights recent progress in research on TSPO-based diagnostic imaging and therapeutics for GM.
authors.affiliation: Faculty of Health Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
authors.forename: Eryn L
authors.initials: EL
authors.lastname: Werry
authors.affiliation: Faculty of Health Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Barron
authors.affiliation: Faculty of Health Sciences, The University of Sydney, Sydney, NSW 2006, Australia School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia michael.kassiou@sydney.edu.au.
authors.forename: Michael
authors.initials: M
authors.lastname: Kassiou
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism; D002986:Clinical Trials as Topic; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D018079:Receptors, GABA / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D000970:Antineoplastic Agents; D018079:Receptors, GABA; C499229:TSPO protein, human
keywords: apoptosis; drug design; glioblastoma; translocator protein