title: Association of Left Ventricular Hypertrophy With a Faster Rate of Renal Function Decline in Elderly Patients With Non-End-Stage Renal Disease.
abstract: BACKGROUND
  Several studies have indicated that chronic kidney disease is independently associated with the presence of left ventricular hypertrophy (LVH). However, little clinical data are currently available regarding the detailed correlation between LVH and renal function in elderly patients with non-end-stage renal disease.
  
  
  RESULTS
  A total of 300 in- and outpatients (more than 60 years of age, non-end-stage renal disease), 251 with LVH and 49 without LVH, seen at Beijing Friendship Hospital from January 2000 to December 2010 were included in this retrospective study. One observation period of 12 months was used to detect rapid kidney function decline. The evaluations of cardiac structure and function were performed via echocardiography. The multivariable logistic analysis showed patients with LVH had a much higher risk of rapid kidney function decline than those without LVH. Additionally, the baseline left ventricular mass index was 140 (125-160) g/m(2) in the non-chronic kidney disease group, 152 (130-175) g/m(2) in the mild chronic kidney disease group (estimated glomerular filtration rate (eGFR)≥60 ml/min/1.73 m(2)), and 153 (133-183) g/m(2) in the severe chronic kidney disease group (eGFR<60 ml/min/1.73 m(2)), with a significant difference (P=0.009).
  
  
  CONCLUSIONS
  Our data demonstrate that a high rate of renal function decline contributes to pathological LVH in non-end-stage renal disease elderly patients and that LVH is positively associated with renal function decline followed by an increased risk of rapid kidney function decline.
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (H.S., X.W., H.L., G.Q.) Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China (H.S., Z.H., J.G., J.G.).
authors.forename: Hong-tao
authors.initials: HT
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (H.S., X.W., H.L., G.Q.).
authors.forename: Xiao-jing
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Yuhuangding Hospital, Qingdao Medical College, Qingdao University, Yantai, Shandong Province, China (J.L., G.S.).
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiology, Yuhuangding Hospital, Qingdao Medical College, Qingdao University, Yantai, Shandong Province, China (J.L., G.S.).
authors.forename: Gui-fang
authors.initials: GF
authors.lastname: Song
authors.affiliation: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China (H.S., Z.H., J.G., J.G.).
authors.forename: Zhe-yong
authors.initials: ZY
authors.lastname: Huang
authors.affiliation: School of Pharmaceutical Science, Capital Medical University, Beijing, China (X.G.).
authors.forename: Xiang-yu
authors.initials: XY
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China (H.S., Z.H., J.G., J.G.) Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China (J.G.).
authors.forename: Jun-jie
authors.initials: JJ
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Yichang Central People's Hospital, Institute of Cardiovascular Diseases, China Three Gorges University, Yichang, Hubei Province, China (Z.L.).
authors.forename: Zhi-yang
authors.initials: ZY
authors.lastname: Lv
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (H.S., X.W., H.L., G.Q.).
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Li
authors.affiliation: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China (H.S., Z.H., J.G., J.G.).
authors.forename: Jun-bo
authors.initials: JB
authors.lastname: Ge
authors.affiliation: Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (J.C.).
authors.forename: Jie
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China (H.S., X.W., H.L., G.Q.).
authors.forename: Guan-ming
authors.initials: GM
authors.lastname: Qi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D002681:China; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014463:Ultrasonography; D020257:Ventricular Remodeling
keywords: chronic kidney disease; left ventricular hypotrophy; left ventricular mass index; non–end‐stage renal disease; rapid kidney function decline