title: Serum Levels of sRAGE Are Associated with Body Measurements, but Not Glycemic Parameters in Patients with Prediabetes.
abstract: BACKGROUND
  Our aim was to assess serum levels of the soluble receptor for advanced glycation end products (sRAGE) and to examine their association with anthropometric and metabolic parameters in patients with prediabetes and obese controls.
  
  
  METHODS
  The two study groups were composed of 42 patients with prediabetes and diabetic neuropathy and 42 age-, gender-, body weight (BW)-, and body mass index (BMI)-matched obese adults as the control group. Prediabetes was diagnosed by the following criteria issued by the American Diabetes Association: impaired fasting glucose [fasting plasma glucose (FPG) level of 100-125 mg/dL], impaired glucose tolerance (2 hr plasma glucose level of 140-199 mg/dL after a 75 grams oral glucose challenge), or a glycated hemoglobin (HbA1C) level of 5.7%-6.4%.
  
  
  RESULTS
  There were no differences between the groups in terms of age, gender distribution, BW, or BMI. Despite these similarities, patients with prediabetes had higher FPG, HbA1c, and 2-hr postchallenge glucose levels, higher systolic and diastolic blood pressure, and larger waist and hip circumferences compared with the obese controls. Lipid measurements, complete blood counts, kidney and liver function tests, high-sensitivity C-reactive protein, and sRAGE levels were similar between the two groups. We found significant negative correlations between sRAGE levels and BW, BMI, waist and hip circumferences, waist-to-hip ratios, and low-density lipoprotein (LDL) cholesterol levels. There were no significant correlations with other parameters, including demographic, metabolic, and blood pressure measurements.
  
  
  CONCLUSIONS
  In contrast to glycemic parameters, serum levels of sRAGE were negatively correlated with body measurements indicative of obesity in the prediabetic state. In addition, the negative correlation with LDL cholesterol levels suggests that sRAGE has a more robust association with metabolic syndrome than with prediabetes.
authors.affiliation: 1 Department of Endocrinology and Metabolism, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .
authors.forename: Metin
authors.initials: M
authors.lastname: Guclu
authors.affiliation: 2 Department of Neurology, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .
authors.forename: Asuman
authors.initials: A
authors.lastname: Ali
authors.affiliation: 3 Department of Internal Medicine, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .
authors.forename: Derya Ustun
authors.initials: DU
authors.lastname: Eroglu
authors.affiliation: 4 Department of Biochemistry, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .
authors.forename: Sema Oral
authors.initials: SO
authors.lastname: Büyükuysal
authors.affiliation: 1 Department of Endocrinology and Metabolism, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .
authors.forename: Soner
authors.initials: S
authors.lastname: Cander
authors.affiliation: 4 Department of Biochemistry, Sevket Yilmaz Research and Training Hospital-Bursa , Bursa, Turkey .
authors.forename: Nihal
authors.initials: N
authors.lastname: Ocak
mesh_terms: D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D003929:Diabetic Neuropathies / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D011236:Prediabetic State / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D000067759:Receptor for Advanced Glycation End Products; C000593871:AGER protein, human; C517652:hemoglobin A1c protein, human