title: Mechanisms of Cardiotoxicity and the Development of Heart Failure.
abstract: Cardiotoxicity is a broad term that refers to the negative effects of toxic substances on the heart. Cancer drugs can cause cardiotoxicity by effects on heart cells, thromboembolic events, and/or hypertension that can lead to heart failure. Rheumatoid arthritis biologics may interfere with ischemic preconditioning and cause/worsen heart failure. Long-term and heavy alcohol use can result in oxidative stress, apoptosis, and decreased contractile protein function. Cocaine use results in sympathetic nervous system stimulation of heart and smooth muscle cells and leads to cardiotoxicity and evolution of heart failure. The definition of cardiotoxicity is likely to evolve along with knowledge about detecting subclinical myocardial injury.
authors.affiliation: School of Nursing and Knight Cardiovascular Institute, Oregon Health and Science University, Mail Code: SN-2N, 3455 SW, US Veterans Hospital Road, Portland, OR 97239-2941, USA. Electronic address: leechri@ohsu.edu.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Lee
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000633:toxicity*; D066126:Cardiotoxicity; D003042:Cocaine / Q000633:toxicity; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology
chemical_list: D000970:Antineoplastic Agents; D003042:Cocaine
keywords: Cardiomyopathy; Cardiotoxicity; Heart failure; Pathophysiology; Toxicity