title: Extensive intestinal metaplasia of renal pelvis: Report of a case and literature review.
abstract: Transformation of the urothelium to the intestinal type of epithelium is rare in the pelvis with very few cases reported in the literature. The present study reports extensive intestinal metaplasia of the pelvi-calyceal system without residual urothelium in a 35-years-old woman with a 2 years history of renal calculi. Right - sided Nephrectomy was undertaken. Immunohistochemistry of the metaplastic epithelium revealed positive expression of CK20, low Ki-67 index and negative expression of p53. In this patient long standing metaplastic changes did not progress to adenocarcinoma which indicates that extensive intestinal metaplasia is not always associated with malignancy.
authors.forename: Prakriti
authors.initials: P
authors.lastname: Shukla
authors.affiliation: Department of Pathology, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.
authors.forename: Hanni V
authors.initials: HV
authors.lastname: Gulwani
mesh_terms: D000328:Adult; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology*; D053554:Keratin-20 / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D007682:Kidney Pelvis / Q000473:pathology*; D008679:Metaplasia / Q000175:diagnosis*; D008853:Microscopy; D009392:Nephrectomy; D011860:Radiography, Abdominal; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: C507499:KRT20 protein, human; D053554:Keratin-20; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53