title: [Distribution of β3-adrenergic receptors gene polymorphisms and its association with serum lipid in Han and Uighur populations in Xinjiang].
abstract: OBJECTIVE
  To investigate the distribution of β3-adrenergic receptors (ADRβ3) gene polymorphisms (rs2298423 and rs6986132) and its association with serum lipid in Han and Uighur populations in Xinjiang.
  
  
  METHODS
  Genotypes of the ADR β 3 gene were detected in 362 Uighur and 653 Han healthy individuals who were randomly selected in Xinjiang by real-time PCR (TaqMan) method.
  
  
  RESULTS
  1) Frequencies of TT, GT and GG genotypes of the rs2298423 locus were 76.5%, 22.1% and 1.4% in the Uighurs but 74.7%, 23.3% and 2.0% in the Hans. There was no significant difference noticed in distribution of genotypes between the two populations (P = 0.695). 2) Frequencies of GG, AG and AA genotypes of the rs6986132 locus were 81.5%, 16.6% and 1.9% in Uighurs but 59.6%, 33.7% and 6.7% in Hans. There was significant difference noticed in the distribution of genotypes between the two populations (P < 0.001). 3) Total cholesterol and low density lipoprotein cholesterol levels were significantly higher in GG or GT genotypes than in the TT genotype carriers of rs2298423 in the Uighur individuals (P < 0.01), but not in the Han population. Serum lipid level that including total cholesterol (TC), low density lipoproteins cholesterol (LDL-C), triglyceride and high density lipoproteins cholesterol did not show significant differences in the distribution of rs6986132 genotypes between the two populations (P > 0.05). After adjusting for factors as gender, age, height, weight, waist circumference, blood urea nitrogen, creatin, glucose, triglyceride, smoking, drinking, results from the logistic regression analyses revealed that those individuals who were carrying GG or GT genotype of rs2298423 were expected to face an increased risk for total cholesterol and low density lipoprotein cholesterol level than those individuals that carrying TT genotype in Uighur populations (OR = 3.140, 95% CI: 1.270-7.764, P = 0.013 in TC level; OR = 3.818, 95% CI: 1.761-8.280, P = 0.001 in LDL-C level). 4) The T-G haplotype appeared more frequent in the Uighurs while the T-A haplotype was more commonly seen in the Han population, respectively (both P < 0.001).
  
  
  CONCLUSIONS
  The mutational frequencies of the tagging SNPs in rs2298423 and rs6986132 loci of the ADRβ 3 gene presented obvious differences between Han and Uighur populations of Xinjiang. G allele carriers of rs2298423 seemed to face an increased risk for TC and LDL-C level in the Uighur populations in Xinjiang.
authors.affiliation: The Cardiovascular Center.
authors.forename: Jinyu
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The Cardiovascular Center.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Li
authors.affiliation: The Cardiovascular Center; Email: yangyn5126@163.com.
authors.forename: Yining
authors.initials: Y
authors.lastname: Yang
authors.affiliation: The Cardiovascular Center.
authors.forename: Yitong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: The Cardiovascular Center.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: The Cardiovascular Center.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Key Laboratory of Cardiovascular Disease Research, the First Affiliated Hospital of Xinjiang Medical University, Urumuqi 830054, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Key Laboratory of Cardiovascular Disease Research, the First Affiliated Hospital of Xinjiang Medical University, Urumuqi 830054, China.
authors.forename: Bangdang
authors.initials: B
authors.lastname: Chen
authors.affiliation: The Cardiovascular Center.
authors.forename: Shuo
authors.initials: S
authors.lastname: Pan
authors.affiliation: The Cardiovascular Center.
authors.forename: Xinghui
authors.initials: X
authors.lastname: Dong
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008055:Lipids / Q000097:blood*; D020641:Polymorphism, Single Nucleotide; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D022702:Receptors, Adrenergic, beta-3; D014280:Triglycerides; D002784:Cholesterol