title: Evaluation of oxidative and antioxidative parameters in generalized anxiety disorder.
abstract: Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder. The exact causes of GAD still unknown, in addition to neurochemical and neuroanatomic disorders, genetic and environmental factors are discussed in etiology. In our study we aimed to evaluate the oxidative metabolism's status and investigate the role of oxidative metabolites in GAD. Blood samples were taken from enrolled subjects in appropriate way and total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were studied in Harran University Biochemistry Labs. Results were compared between groups. The patients' TOS and OSI levels were significantly higher than control group. The patients' TAS levels were significantly lower than controls'. According to our findings, oxidative stress mechanism might have a role in GAD pathophysiology. In the future, total antioxidants may be used as a biologic marker in GAD etiology but more research is needed.
authors.affiliation: Clinic of Psychiatry, Ministry of Health, Diyarbakır Education and Research Hospital, Diyarbakır, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Emhan
authors.affiliation: Harris County Psychiatric Center, University of Texas Health Science Center at Houston, TX, USA. Electronic address: drselek@yahoo.com.
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Bayazıt
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Fatih Karababa
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Katı
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001008:Anxiety Disorders / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants
keywords: Generalized anxiety disorder; Oxidative stress; Total antioxidant status; Total oxidant status