title: Involvement of dietary saturated fats, from all sources or of dairy origin only, in insulin resistance and type 2 diabetes.
abstract: Reducing the consumption of saturated fatty acids to a level as low as possible is a European public health recommendation to reduce the risk of cardiovascular disease. The association between dietary intake of saturated fatty acids and development and management of type 2 diabetes mellitus (T2DM), however, is a matter of debate. A literature search was performed to identify prospective studies and clinical trials in humans that explored the association between dietary intake of saturated fatty acids and risk of insulin resistance and T2DM. Furthermore, to assess whether specific foods, and not just the saturated fatty acid content of the food matrix, can have differential effects on human health, the relationship between consumption of full-fat dairy products, a main source of dietary saturated fatty acids, and risk of insulin resistance and T2DM was studied. There is no evidence that dietary saturated fatty acids from varied food sources affect the risk of insulin resistance or T2DM, nor is intake of full-fat dairy products associated with this risk. These findings strongly suggest that future studies on the effects of dietary saturated fatty acids should take into account the complexity of the food matrix. Furthermore, communication on saturated fats and their health effects should be prudent and well informed.
authors.affiliation: B. Morio is with the CarMeN Laboratory (Inserm 1060, INRA 1397, INSA), University of Lyon, Faculty of Medicine Lyon - South, Oullins, France. B. Morio and A. Fardet are with the French National Institute for Agricultural Research (INRA), UMR1019 Human Nutrition, Center for Human Nutrition Research (CRNH) Auvergne, Clermont-Ferrand, France. P. Legrand is with the Biochemistry and Human Nutrition Laboratory, Agrocampus - French National Institute for Agricultural Research (INRA), Rennes, France. J-M. Lecerf is with the Nutrition Department, Pasteur Institute of Lille, Lille, France. beatrice.morio@lyon.inra.fr.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Morio
authors.affiliation: B. Morio is with the CarMeN Laboratory (Inserm 1060, INRA 1397, INSA), University of Lyon, Faculty of Medicine Lyon - South, Oullins, France. B. Morio and A. Fardet are with the French National Institute for Agricultural Research (INRA), UMR1019 Human Nutrition, Center for Human Nutrition Research (CRNH) Auvergne, Clermont-Ferrand, France. P. Legrand is with the Biochemistry and Human Nutrition Laboratory, Agrocampus - French National Institute for Agricultural Research (INRA), Rennes, France. J-M. Lecerf is with the Nutrition Department, Pasteur Institute of Lille, Lille, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Fardet
authors.affiliation: B. Morio is with the CarMeN Laboratory (Inserm 1060, INRA 1397, INSA), University of Lyon, Faculty of Medicine Lyon - South, Oullins, France. B. Morio and A. Fardet are with the French National Institute for Agricultural Research (INRA), UMR1019 Human Nutrition, Center for Human Nutrition Research (CRNH) Auvergne, Clermont-Ferrand, France. P. Legrand is with the Biochemistry and Human Nutrition Laboratory, Agrocampus - French National Institute for Agricultural Research (INRA), Rennes, France. J-M. Lecerf is with the Nutrition Department, Pasteur Institute of Lille, Lille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Legrand
authors.affiliation: B. Morio is with the CarMeN Laboratory (Inserm 1060, INRA 1397, INSA), University of Lyon, Faculty of Medicine Lyon - South, Oullins, France. B. Morio and A. Fardet are with the French National Institute for Agricultural Research (INRA), UMR1019 Human Nutrition, Center for Human Nutrition Research (CRNH) Auvergne, Clermont-Ferrand, France. P. Legrand is with the Biochemistry and Human Nutrition Laboratory, Agrocampus - French National Institute for Agricultural Research (INRA), Rennes, France. J-M. Lecerf is with the Nutrition Department, Pasteur Institute of Lille, Lille, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Lecerf
mesh_terms: D003611:Dairy Products; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology*; D006801:Humans; D007333:Insulin Resistance
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids
keywords: human; lipid nutrition; prevention of diabetes; public health; saturated fatty acids