title: Primary Vitreoretinal Lymphoma Masquerading as Refractory Retinitis.
abstract: OBJECTIVE
  To report a case of a patient with primary vitreoretinal lymphoma masquerading as retinitis.
  
  
  METHODS
  Retrospective review of the patient's clinical, histopathological and imaging records.
  
  
  RESULTS
  Cytopathology was negative for malignancy, and preliminary polymerase chain reaction results supported the diagnosis of varicella zoster virus retinitis. Therefore, the patient was treated with antiviral therapy. However, under this treatment, the retinitis progressed. As a result, primary vitreoretinal lymphoma was suspected, and empirical treatment with intravitreal methotrexate injections was started. Under this treatment, the ocular features improved. Five months after initial ocular presentation and ocular resolution, the patient presented with central nervous system lymphoma.
  
  
  CONCLUSIONS
  This case should raise the awareness of the variable clinical presentations, the challenging diagnosis and treatment of primary vitreoretinal lymphoma. All cases should be continuously systemically evaluated.
authors.affiliation: The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, and The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ofira
authors.initials: O
authors.lastname: Zloto
authors.affiliation: The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, and The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Amir E Abd
authors.initials: AE
authors.lastname: Elkader
authors.affiliation: The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, and The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ido Didi
authors.initials: ID
authors.lastname: Fabian
authors.affiliation: The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, and The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Vicktoria
authors.initials: V
authors.lastname: Vishnevskia-Dai
keywords: Diagnostic vitrectomy; Intravitreal methotrexate; Posterior uveitis; Primary central nervous system lymphoma; Primary vitreoretinal lymphoma