title: Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics.
abstract: Theranostic tantalum oxide nanoparticles (TaOxNPs) of about 40 nm were successfully developed by conjugating functional molecules including polyethylene glycol (PEG), near-infrared (NIR) fluorescent dye, doxorubicin (DOX), and hyaluronic acid (HA) onto the surface of the nanoparticles (TaOx@Cy7-DOX-PEG-HA NPs) for actively targeting delivery, pH-responsive drug release, and NIR fluorescence/X-ray CT bimodal imaging. The obtained nanoagent exhibits good biocompatibility, high cumulative release rate in the acidic microenvironments, long blood circulation time, and superior tumor-targeting ability. Both in vitro and in vivo experiments show that it can serve as an excellent contrast agent to simultaneously enhance fluorescence imaging and CT imaging greatly. Most importantly, such a nanoagent could enhance the therapeutic efficacy of the tumor greatly and the tumor growth inhibition was evaluated to be 87.5%. In a word, multifunctional TaOx@Cy7-DOX-PEG-HA NPs can serve as a theranostic nanomedicine for fluorescence/X-ray CT bimodal imaging, remote-controlled therapeutics, enabling personalized detection, and treatment of cancer with high efficacy.
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology , Harbin 150001, PR China.
authors.forename: Yushen
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Institute of Automation, Chinese Academy of Sciences , Beijing 100190, PR China.
authors.forename: Xibo
authors.initials: X
authors.lastname: Ma
authors.affiliation: School of Municipal and Environmental Engineering, Harbin Institute of Technology , Harbin 150001, PR China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Feng
authors.affiliation: Institute of Automation, Chinese Academy of Sciences , Beijing 100190, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University , Beijing 100871, PR China.
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Institute of Automation, Chinese Academy of Sciences , Beijing 100190, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: School of Municipal and Environmental Engineering, Harbin Institute of Technology , Harbin 150001, PR China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Yue
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D061848:Optical Imaging; D010087:Oxides / Q000737:chemistry*; D013635:Tantalum / Q000737:chemistry*; D000068936:Theranostic Nanomedicine
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D010087:Oxides; D013635:Tantalum; D004317:Doxorubicin; D006820:Hyaluronic Acid; C078151:tantalum oxide