title: Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN.
abstract: Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aim of standardizing the kidney biopsy report of GN. On the basis of etiology/pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulopathy. The pathogenesis-based classification forms the basis of the kidney biopsy report. To standardize the report, the diagnosis consists of a primary diagnosis and a secondary diagnosis. The primary diagnosis should include the disease entity/pathogenic type (if disease entity is not known) followed in order by pattern of injury (mixed patterns may be present); score/grade/class for disease entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional features as detailed herein. A pattern diagnosis as the sole primary diagnosis is not recommended. Secondary diagnoses should be reported separately and include coexisting lesions that do not form the primary diagnosis. Guidelines for the report format, light microscopy, immunofluorescence microscopy, electron microscopy, and ancillary studies are also provided. In summary, this consensus report emphasizes a pathogenesis-based classification of GN and provides guidelines for the standardized reporting of GN.
authors.affiliation: Mayo Clinic, Rochester, Minnesota sethi.sanjeev@mayo.edu fervenza.fernando@mayo.edu.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sethi
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Mark
authors.initials: M
authors.lastname: Haas
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Glen S
authors.initials: GS
authors.lastname: Markowitz
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Vivette D
authors.initials: VD
authors.lastname: D'Agati
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Helmut G
authors.initials: HG
authors.lastname: Rennke
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: J Charles
authors.initials: JC
authors.lastname: Jennette
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Ingeborg M
authors.initials: IM
authors.lastname: Bajema
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Alpers
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Anthony
authors.initials: A
authors.lastname: Chang
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Lynn D
authors.initials: LD
authors.lastname: Cornell
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Fernando G
authors.initials: FG
authors.lastname: Cosio
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Agnes B
authors.initials: AB
authors.lastname: Fogo
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Glassock
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Sundaram
authors.initials: S
authors.lastname: Hariharan
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Neeraja
authors.initials: N
authors.lastname: Kambham
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Lager
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Nelson
authors.initials: N
authors.lastname: Leung
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Michael
authors.initials: M
authors.lastname: Mengel
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Karl A
authors.initials: KA
authors.lastname: Nath
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Ian S
authors.initials: IS
authors.lastname: Roberts
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Brad H
authors.initials: BH
authors.lastname: Rovin
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Surya V
authors.initials: SV
authors.lastname: Seshan
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Richard J H
authors.initials: RJ
authors.lastname: Smith
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Walker
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Winearls
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Appel
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Mariam P
authors.initials: MP
authors.lastname: Alexander
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Cattran
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Carmen Avila
authors.initials: CA
authors.lastname: Casado
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: H Terence
authors.initials: HT
authors.lastname: Cook
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: An S
authors.initials: AS
authors.lastname: De Vriese
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Jai
authors.initials: J
authors.lastname: Radhakrishnan
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Lorraine C
authors.initials: LC
authors.lastname: Racusen
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Pierre
authors.initials: P
authors.lastname: Ronco
authors.affiliation: Mayo Clinic, Rochester, Minnesota.
authors.forename: Fernando C
authors.initials: FC
authors.lastname: Fervenza
mesh_terms: D005921:Glomerulonephritis / Q000145:classification* / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D058028:Research Report; D009626:Terminology as Topic
keywords: glomerulonephritis; kidney biopsy; renal biopsy