title: N-Acetyl cysteine (NAC)-mediated reinforcement of alpha-tricalcium phosphate/silk fibroin (α-TCP/SF) cement.
abstract: Calcium phosphate cements (CPCs) are popular bone filling materials and drug carriers. However poor mechanical properties and lack of osteoinduction restrict their clinical applications. Recent studies suggested the osteogenic properties of NAC. In our study, we incorporated NAC with α-TCP/SF. We found that the compressive strength of α-TCP/SF-NAC composites increased with increase in NAC concentration, possibly due to complex three-dimensional networks of SF induced by NAC, which was large and chemically heterogeneous and induced compact oriented growth of HA crystals. However the setting time increased slightly with the addition of NAC, due to the ruptured disulfide bonds in SF. The α-TCP/SF-NAC composites also showed decent biocompatibility in vitro. As a result, these composites hold great potential as bone filling materials for clinical applications, including minimally invasive surgeries.
authors.affiliation: Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.affiliation: Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Pi
authors.affiliation: Orthopedic Institute of Soochow University, Suzhou 215006, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Yi-Meng
authors.initials: YM
authors.lastname: Wang
authors.affiliation: Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address: zhuxs@126.com.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Zhu
authors.affiliation: Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address: hlyang@suda.edu.cn.
authors.forename: Hui-Lin
authors.initials: HL
authors.lastname: Yang
mesh_terms: D000111:Acetylcysteine / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials; D002130:Calcium Phosphates / Q000737:chemistry*; D005349:Fibroins / Q000737:chemistry*; D051381:Rats
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; D005349:Fibroins; D000111:Acetylcysteine
keywords: Biocompatibility; Mechanical reinforcement; NAC; Silk fibroin; α-Tricalcium phosphate