title: Antioxidants, Enzyme Inhibitors, and Biogenic Compounds in Grain Extracts of Barleys.
abstract: The content of biogenic compounds and the biological activities of barley (Hordeum vulgare L.)-grain extracts was evaluated. The sufficiently large and heterogeneous set of barley genotypes (100 accessions) enabled the selection of special genotypes interesting for potential industrial, pharmaceutical, and medicinal applications. Barley genotypes with the highest contents of phenols, phenolic acids, flavonoids, biogenic thiols, and amines, radical-scavenging activity, as well as inhibitory activities of trypsin, thrombin, collagenase, urokinase, and cyclooxygenase were identified.
authors.affiliation: Department of Biotechnology, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Nám. J. Herdu 2, SK-91701 Trnava.
authors.forename: Tibor
authors.initials: T
authors.lastname: Maliar
authors.affiliation: Department of Biotechnology, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Nám. J. Herdu 2, SK-91701 Trnava.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Slaba
authors.affiliation: Department of Chemistry, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Nám. J. Herdu 2, SK-91701 Trnava.
authors.forename: Peter
authors.initials: P
authors.lastname: Nemeček
authors.affiliation: Department of Chemistry, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Nám. J. Herdu 2, SK-91701 Trnava.
authors.forename: Mária
authors.initials: M
authors.lastname: Maliarová
authors.affiliation: National Agricultural and Food Centre, Research Institute of Plant Production, Bratislavská cesta 122, SK-92168 Piešt'any (phone: +421-33-7722311; fax: +421-33-7726306).
authors.forename: Michaela
authors.initials: M
authors.lastname: Benková
authors.affiliation: Department of Biotechnology, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Nám. J. Herdu 2, SK-91701 Trnava.|National Agricultural and Food Centre, Research Institute of Plant Production, Bratislavská cesta 122, SK-92168 Piešt'any (phone: +421-33-7722311; fax: +421-33-7726306).
authors.forename: Michaela
authors.initials: M
authors.lastname: Havrlentová
authors.affiliation: Department of Biotechnology, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Nám. J. Herdu 2, SK-91701 Trnava.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Ondrejovič
authors.affiliation: Department of Biotechnology, Faculty of Natural Sciences, University of SS. Cyril and Methodius, Nám. J. Herdu 2, SK-91701 Trnava. kraic@vurv.sk.|National Agricultural and Food Centre, Research Institute of Plant Production, Bratislavská cesta 122, SK-92168 Piešt'any (phone: +421-33-7722311; fax: +421-33-7726306). kraic@vurv.sk.
authors.forename: Ján
authors.initials: J
authors.lastname: Kraic
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017364:Collagenases / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005838:Genotype; D001467:Hordeum / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D011451:Prostaglandin-Endoperoxide Synthases; D014357:Trypsin; D013917:Thrombin; D014568:Urokinase-Type Plasminogen Activator; D017364:Collagenases
keywords: Antioxidant; Barley; Cluster analysis (CA); Flavonoids; Grain extract; Hordeum vulgare; Phenols; Principal component analysis (PCA); Protease inhibitor; Radical-scavenging activity