title: A System Calibration and Fast Iterative Reconstruction Method for Next-Generation SPECT Imagers.
abstract: Recently, high-resolution gamma cameras have been developed with detectors containing> 105-106elements. SPECT imagers based on these detectors usually also have a large number of voxel bins and therefore face memory storage issues for the system matrix when performing fast tomographic reconstructions using iterative algorithms. To address these issues, we have developed a method that parameterizes the detector response to a point source and generates the system matrix on the fly during MLEM or OSEM on graphics hardware. The calibration method, interpolation of coefficient data, and reconstruction results are presented in the context of a recently commissioned small-animal SPECT imager, called FastSPECT III.
authors.affiliation: Center for Gamma-Ray Imaging and the College of Optical Sciences, University of Arizona, Tucson, AZ 85724 USA.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Miller
authors.affiliation: MEDISIP, Department of Electronics and Information Systems, Ghent University, B-9000 Ghent, Belgium. He is supported by a postdoctoral fellowship of the Research Foundation (FWO).
authors.forename: Roel
authors.initials: R
authors.lastname: Van Holen
authors.affiliation: Center for Gamma-Ray Imaging and the College of Optical Sciences, University of Arizona, Tucson, AZ 85724 USA.
authors.forename: Harrison H
authors.initials: HH
authors.lastname: Barrett
authors.affiliation: Center for Gamma-Ray Imaging and the College of Optical Sciences, University of Arizona, Tucson, AZ 85724 USA.
authors.forename: Lars R
authors.initials: LR
authors.lastname: Furenlid
keywords: OSEM; Single-photon emission computed tomography (SPECT); calibration; graphics processing units; high-performance computing; image reconstruction; system matrix