title: Association of specific frequency bands of functional MRI signal oscillations with motor symptoms and depression in Parkinson's disease.
abstract: A novel empirical mode decomposition method was adopted to investigate the dissociative or interactive neural impact of depression and motor impairments in Parkinson's disease (PD). Resting-state fMRI data of 59 PD subjects were first decomposed into characteristic frequency bands, and the main effects of motor severity and depression and their interaction on the energy of blood-oxygen-level-dependent signal oscillation in specific frequency bands were then evaluated. The results show that the severity of motor symptoms is negatively correlated with the energy in the frequency band of 0.10-0.25 Hz in the bilateral thalamus, but positively correlated with 0.01-0.027 Hz band energy in the bilateral postcentral gyrus. The severity of depression, on the other hand, is positively correlated with the energy of 0.10-0.25 Hz but negatively with 0.01-0.027 Hz in the bilateral subgenual gyrus. Notably, the interaction between motor and depressive symptoms is negatively correlated with the energy of 0.10-0.25 Hz in the substantia nigra, hippocampus, inferior orbitofrontal cortex, and temporoparietal junction, but positively correlated with 0.02-0.05 Hz in the same regions. These findings indicate unique associations of fMRI band signals with motor and depressive symptoms in PD in specific brain regions, which may underscore the neural impact of the comorbidity and the differentiation between the two PD-related disorders.
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Neurology, Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.
authors.forename: Shuqin
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, Shanxi 710071, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry and Psychosomatics, Affiliated ZhongDa Hospital of Southeast University, Institute of Neuropsychiatry of Southeast University, Nanjing 210009, China.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.
authors.forename: Huaiqiu
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China.|Center for MRI Research, Beijing City Key Lab for Medical Physics and Engineering, McGovern Institution for Brain Research, Peking University, Beijing, 100871, China.
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D003863:Depression / Q000150:complications* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011859:Radiography; D012044:Regression Analysis