title: Amphiphilic graft copolymers with ethyl cellulose backbone: Synthesis, self-assembly and tunable temperature-CO2 response.
abstract: Amphiphilic ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate) (EC-g-PDMAEMA) and ethyl cellulose-graft-poly(2-(2-methoxyethoxy)ethyl methacrylate-co-N,N-dimethylaminoethyl methacrylate) (EC-g-P(MEO2MA-co-DMAEMA)) graft copolymers were easily synthesized by atom transfer radical polymerization (ATRP). The micelles self-assembled from the copolymer presented switchable temperature-CO2 dually responsive properties. The value of lower critical solution temperature (LCST) for the copolymer micelle solutions could be adjusted by CO2/Ar. Moreover, due to the alteration of the ratio of DMAEMA to MEO2MA, the LCST values of the micelle solutions decreased with the increase of MEO2MA in copolymer. The temperature-CO2 dually responsive properties of the copolymer were reversible and could be accomplished through altering the temperature and bubbling CO2/Ar. The hydrodynamic radius (Rh) of the copolymer micelles was also influenced by the ratio of DMAEMA to MEO2MA and the stimuli of temperature and CO2/Ar. As a drug release system, the copolymer micelles could achieve the control release of doxorubicin (DOX) by changing the temperature and alternatively bubbling CO2/Ar.
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Civil Materials of Ministry of Education, Tongji University, 201804, People's Republic of China. Electronic address: yuanwz@tongji.edu.cn.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Yuan
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Civil Materials of Ministry of Education, Tongji University, 201804, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zou
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Civil Materials of Ministry of Education, Tongji University, 201804, People's Republic of China.
authors.forename: Jin
authors.initials: J
authors.lastname: Shen
mesh_terms: D000388:Air; D002245:Carbon Dioxide / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000737:chemistry; D008823:Micelles; D009757:Nylons / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008689:Methacrylates; D008823:Micelles; D009757:Nylons; D011108:Polymers; C407037:poly(2-(dimethylamino)ethyl methacrylate); D002245:Carbon Dioxide; C013517:ethyl cellulose; D004317:Doxorubicin; D002482:Cellulose; C049840:2-(dimethylamino)ethyl methacrylate
keywords: CO(2)-responsive; Graft copolymers; Micelles; Self-assembly; Temperature-responsive