title: Novel Nanotechnologies for Brain Cancer Therapeutics and Imaging.
abstract: Despite progress in surgery, radiotherapy, and in chemotherapy, an effective curative treatment of brain cancer, specifically malignant gliomas, does not yet exist. The efficacy of current anti-cancer strategies in brain tumors is limited by the lack of specific therapies against malignant cells. Besides, the delivery of the drugs to brain tumors is limited by the presence of the blood-brain barrier. Nanotechnology today offers a unique opportunity to develop more effective brain cancer imaging and therapeutics. In particular, the development of nanocarriers that can be conjugated with several functional molecules including tumor-specific ligands, anticancer drugs, and imaging probes, can provide new devices which are able to overcome the difficulties of the classical strategies. Nanotechnology-based approaches hold great promise for revolutionizing brain cancer medical treatments, imaging, and diagnosis.
authors.forename: Letizia
authors.initials: L
authors.lastname: Ferroni
authors.forename: Chiara
authors.initials: C
authors.lastname: Gardin
authors.forename: Alessandro
authors.initials: A
authors.lastname: Della Puppa
authors.forename: Stefano
authors.initials: S
authors.lastname: Sivolella
authors.forename: Giulia
authors.initials: G
authors.lastname: Brunello
authors.forename: Renato
authors.initials: R
authors.lastname: Scienza
authors.forename: Eriberto
authors.initials: E
authors.lastname: Bressan
authors.forename: Domenico
authors.initials: D
authors.lastname: D'Avella
authors.forename: Barbara
authors.initials: B
authors.lastname: Zavan
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D003952:Diagnostic Imaging / Q000379:methods*; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine / Q000379:methods*