title: Spinal glial activation and oxidative stress are alleviated by treatment with curcumin or coenzyme Q in sickle mice.
authors.affiliation: Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN.
authors.forename: Yessenia
authors.initials: Y
authors.lastname: Valverde
authors.affiliation: Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN.
authors.forename: Barbara
authors.initials: B
authors.lastname: Benson
authors.affiliation: Department of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
authors.forename: Mihir
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN gupta014@umn.edu.
authors.forename: Kalpna
authors.initials: K
authors.lastname: Gupta
mesh_terms: D000284:Administration, Oral; D000755:Anemia, Sickle Cell / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D003474:Curcumin / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation; D005904:Glial Fibrillary Acidic Protein / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006930:Hyperalgesia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009479:Neuropeptides / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D059225:Nociception / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010146:Pain / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D066148:Spinal Cord Dorsal Horn / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D014451:Ubiquinone / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005904:Glial Fibrillary Acidic Protein; D009479:Neuropeptides; D017382:Reactive Oxygen Species; C528900:glial fibrillary astrocytic protein, mouse; C539972:neuropeptide S, mouse; D014451:Ubiquinone; D003474:Curcumin
keywords: CoQ10; astrocyte; curcumin; glial; pain; sickle cell anemia