title: [REARRANGEMENT OF THE LYMPH TISSUE IN THE MICE SPLEEN AND JEJUNUM WALL DURING THE GROUND-BASED REPRODUCTION OF THE CONDITIONS OF ANIMAL MAINTENANCE IN THE BIOSATTELITE BION-M1 MISSION].
abstract: Purpose of the investigation was microscopic examination of changes in cyto architectonics of the spleen and jejunum lymph (immune) tissue in 19-20-week C57BL/6N male mice exposed to some conditions their counterparts had lived in during the 30-d Bion-M1 mission (ground experiment). Local deviations in reactions of the morphofunctional zones of these organs were found. In the spleen, reaction in the centers of lymph nodules generation or the B-lymphocytes maturation zone grows strong. Changes in the cell composition of periarterial lymph sheaths that constitute the morphological site of T-lymphocytes accumulation suggest inhibition of its functional activity. Cell composition of the jejunum wall structure implies a decline of the jejunal immune activity. Our investigation of the organs taken from the ground control mice maintained in the flight BIOS-MLZh module evidences that unceasing noise, hypokinesia, isolation, and paste-like feed weaken general immunity of laboratory animals.
authors.forename: D E
authors.initials: DE
authors.lastname: Grigorenko
authors.forename: G G
authors.initials: GG
authors.lastname: Aminova
authors.forename: L M
authors.initials: LM
authors.lastname: Erofeeva
authors.forename: B S
authors.initials: BS
authors.lastname: Shenkman
authors.forename: E A
authors.initials: EA
authors.lastname: Ilyin
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D006098:Granulocytes / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D007113:Immunity, Innate; D007583:Jejunum / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D008264:Macrophages / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013026:Space Flight; D013154:Spleen / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D014893:Weightlessness; D018474:Weightlessness Simulation