title: The quest for spatio-temporal control of CAR T cells.
abstract: Chimeric antigen receptors (CARs) are synthetic receptors capable of directing potent antigen-specific anti-tumor T cell responses. A recent report by Wu et al. extends a series of strategies aiming to curb excessive T cell activity, utilizing in this instance a chemical dimerizer to aggregate antigen-binding, T cell-activating and costimulatory domains.
authors.affiliation: Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.|Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.affiliation: Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.|Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA.
authors.forename: Michel
authors.initials: M
authors.lastname: Sadelain
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000819:agonists*; D054852:Small Molecule Libraries / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000637:transplantation*
chemical_list: D011948:Receptors, Antigen, T-Cell; D054852:Small Molecule Libraries