title: Nano-Hydroxyapatite Doped with Ho-166 as Drug Delivery System for Bone Cancer Therapy and Diagnosis: Developing a Theragnostic Radiopharmaceuticals.
abstract: BACKGROUND
  The use of nanobiomaterials is increasing each day. Among the immense variety of nanomaterials developed and studied the hydroxyapatite is one of the most ones.
  
  
  OBJECTIVE
  In this study we developed and tested nano-hydroxyapatite dopped with Ho-166 for bone cancer.
  
  
  RESULTS
  The results showed that the nano-hydroxyapatite dopped with Ho-166 has a great affinity for the bone.
  
  
  CONCLUSIONS
  The pre-clinical studies support the use as a nano-radiopharmaceuticals for bone cancer treatment and diagnosis.
authors.affiliation: Laboratory of Nanoradiopharmaceuticals, Rio de Janeiro, Brazil.
authors.forename: Franciana Maria Rosa
authors.initials: FMR
authors.lastname: da Silva
authors.affiliation: Laboratory of Nanoradiopharmaceuticals, Rio de Janeiro, Brazil.
authors.forename: Julio Cezar
authors.initials: JC
authors.lastname: de Almeida
authors.affiliation: Nuclear Engineering Institute, Rio de Janeiro, Brazil.
authors.forename: Elizabeth Eugenio de Mello
authors.initials: EEM
authors.lastname: Oliveira
authors.affiliation: University Hospital Clementino Fraga Filho, Rio de Janeiro, Brazil.
authors.forename: Marta
authors.initials: M
authors.lastname: de Souza Albernaz
authors.affiliation: University Hospital Clementino Fraga Filho, Rio de Janeiro, Brazil.
authors.forename: Alexandre Malta
authors.initials: AM
authors.lastname: Rossi
authors.affiliation: Laboratory of Nanoradiopharmaceuticals, Rio de Janeiro, Brazil.
authors.forename: Ralph
authors.initials: R
authors.lastname: Santos-Oliveira
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D006695:Holmium / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; D017886:Durapatite; D006695:Holmium
keywords: Radiopharmaceuticals; nanotechnology; oncology; scanning electron microscopy; transmission electron microscopy