title: Identification of a novel role of RING finger protein 11 promoting the metastasis of murine melanoma cells.
abstract: Melanoma is the leading cause of skin cancer death owing to its highly metastatic nature and resistance to chemotherapy. It may account for 80% of the deaths relating to skin cancers. Once it progressed to metastatic stage, no current effective treatment is available for melanoma. Therefore, in-depth understanding of the mechanism underlying the metastatic process is imperative and would be of great help for improving the treatment of melanoma. Here, wedemonstrate that RING finger protein 11 (RNF11) disruption by insertional mutagenesis impairs the metastatic potential of murine melanoma B16F10 cells. The requirement of RNF11 in the migration of melanoma cells is further confirmed by gene knockdown and overexpression experiments in vitro. Together, our findings suggest a novel role of RNF11 in promoting the metastasis of melanoma cells which may potentially be useful for the treatment of melanoma by developing a new intervention target.
authors.affiliation: College of Life Science and Technology, Xinxiang Medical University Xinxiang 453003, Henan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Life Science and Technology, Xinxiang Medical University Xinxiang 453003, Henan, China.
authors.forename: Hai-Jie
authors.initials: HJ
authors.lastname: Yang
authors.affiliation: School of Public Health, Xinxiang Medical University Xinxiang 453003, Henan, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Gao
authors.affiliation: College of Life Science and Technology, Xinxiang Medical University Xinxiang 453003, Henan, China.
authors.forename: Mian
authors.initials: M
authors.lastname: Wang
authors.affiliation: College of Life Science and Technology, Xinxiang Medical University Xinxiang 453003, Henan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shi
authors.affiliation: College of Life Science and Technology, Xinxiang Medical University Xinxiang 453003, Henan, China.
authors.forename: Bin-Feng
authors.initials: BF
authors.lastname: Cheng
authors.affiliation: College of Life Science and Technology, Xinxiang Medical University Xinxiang 453003, Henan, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Feng
keywords: RNF11; gene knockdown; melanoma; metastasis; overexpression