title: Randomized controlled clinical trial comparing radioguided occult lesion localization with wire-guided lesion localization to evaluate their efficacy and accuracy in the localization of nonpalpable breast lesions.
abstract: OBJECTIVE
  The aim of this study was to compare the radioguided occult lesion localization (ROLL) technique with the wire-guided lesion localization (WGLL) technique to assess their efficacy and accuracy in the localization of nonpalpable breast lesions in patients at a unique reference medical center. These patients' reports were negative for malignancy but included highly suspicious imaging findings.
  
  
  METHODS
  A controlled clinical trial was designed to compare the WGLL and ROLL techniques in women presenting with breast lesions diagnosed by mammography or ultrasonography at the Instituto Nacional de Cancerología in Bogotá, Colombia, from March 2006 to June 2011.
  
  
  RESULTS
  This study examined 129 patients; 64 (49.6%) patients were treated with ROLL, and 65 (51.4%) were treated with WGLL. The ROLL technique achieved better median lesion centricity (ROLL = 11.7 and WGLL = 15.4; P = .038). No significant differences were found regarding demographic variables, operative specimen characteristics, the need to extend margins, operative complications, the degree of difficulty, or patient or surgeon satisfaction.
  
  
  CONCLUSIONS
  The ROLL technique is as effective as WGLL for the localization of nonpalpable breast lesions. In our study, ROLL achieved better lesion centricity. Therefore, we propose that this technique could be used as a standard procedure in the detection of nonpalpable breast lesions at experienced centers.
authors.affiliation: Grupo de Cirugía de Seno y Tejidos Blandos, Instituto Nacional de Cancerología, Bogotá D.C., Colombia. Electronic address: duarte10.carlos@gmail.com.
authors.forename: Carlos
authors.initials: C
authors.lastname: Duarte
authors.affiliation: Grupo de Cirugía de Seno y Tejidos Blandos, Instituto Nacional de Cancerología, Bogotá D.C., Colombia.
authors.forename: Faustino
authors.initials: F
authors.lastname: Bastidas
authors.affiliation: Grupo de Medicina Nuclear, Instituto Nacional de Cancerología, Bogotá D.C., Colombia.
authors.forename: Amelia
authors.initials: A
authors.lastname: de los Reyes
authors.affiliation: Grupo de Medicina Nuclear, Instituto Nacional de Cancerología, Bogotá D.C., Colombia.
authors.forename: María Cristina
authors.initials: MC
authors.lastname: Martínez
authors.affiliation: Grupo de Imágenes Diagnósticas, Instituto Nacional de Cancerología, Bogotá D.C., Colombia.
authors.forename: Gloria
authors.initials: G
authors.lastname: Hurtado
authors.affiliation: Grupo de Patología, Instituto Nacional de Cancerología, Bogotá D.C., Colombia.
authors.forename: María Constanza
authors.initials: MC
authors.lastname: Gómez
authors.affiliation: Grupo de Investigación Clínica, Instituto Nacional de Cancerología, Bogotá D.C., Colombia; Facultad de Medicina Universidad Nacional de Colombia, Bogotá D.C., Colombia.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sánchez
authors.affiliation: Grupo de Cirugía de Seno y Tejidos Blandos, Instituto Nacional de Cancerología, Bogotá D.C., Colombia.
authors.forename: Jorge
authors.initials: J
authors.lastname: Manrique
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis / Q000601:surgery; D005260:Female; D057918:Fiducial Markers; D006801:Humans; D008327:Mammography / Q000379:methods*; D008408:Mastectomy / Q000379:methods*; D008875:Middle Aged; D015641:Radiography, Interventional; D019275:Radiopharmaceuticals; D016037:Single-Blind Method; D013668:Technetium Tc 99m Aggregated Albumin; D016217:Ultrasonography, Mammary; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin