title: Prevalence of sexual dysfunction after risk-reducing salpingo-oophorectomy.
abstract: OBJECTIVE
  To determine the prevalence of sexual dysfunction in women after risk-reducing salpingo-oophorectomy (RRSO) and to assess factors which may influence sexual wellbeing following this procedure.
  
  
  METHODS
  This work is a cross-sectional study of women who underwent RRSO at a tertiary gynecologic oncology unit between January 2009 and October 2014. Data collection involved a comprehensive questionnaire including validated measures of sexual function, sexual distress, relationship satisfaction, body image, impact of event, menopause specific quality of life, and general quality of life. Participants were invited to undergo blood testing for serum testosterone and free androgen index (FAI).
  
  
  RESULTS
  119 of the 206 eligible women participated (58%), with a mean age of 52years. The prevalence of female sexual dysfunction (FSD) was 74% and the prevalence of hypoactive sexual desire disorder (HSDD) was 73%. Common sexual issues experienced included; lubrication difficulty (44%), reduced sexual satisfaction (41%), dyspareunia (28%) and orgasm difficulty (25%). Relationship satisfaction, the use of topical vaginal estrogen and lower generalized body pain were significantly associated with a decreased likelihood of sexual dysfunction. Serum testosterone, FAI, the use of systemic hormone replacement therapy (HRT), prior history of breast cancer, menopausal status at the time of surgery and hysterectomy did not correlate with sexual dysfunction.
  
  
  CONCLUSIONS
  The prevalence of FSD and HSDD after RRSO was 74% and 73% respectively. Relationship satisfaction, low bodily pain and use of topical vaginal estrogen were associated with a lower likelihood of sexual dysfunction. There was no correlation between serum testosterone or FAI, and sexual dysfunction.
authors.affiliation: St John of God Subiaco Hospital, 12 Salvado Rd, Subiaco, WA 6008, Australia; School of Medicine, University of Notre Dame, 19 Mouat St, Fremantle, WA 6160, Australia. Electronic address: Paige.Tucker@sjog.org.au.
authors.forename: Paige E
authors.initials: PE
authors.lastname: Tucker
authors.affiliation: Institute for Health Research, University of Notre Dame, 19 Mouat St, Fremantle, WA 6160, Australia. Electronic address: Max.Bulsara@nd.edu.au.
authors.forename: Max K
authors.initials: MK
authors.lastname: Bulsara
authors.affiliation: St John of God Subiaco Hospital, 12 Salvado Rd, Subiaco, WA 6008, Australia. Electronic address: Stuart.Salfinger@health.wa.gov.au.
authors.forename: Stuart G
authors.initials: SG
authors.lastname: Salfinger
authors.affiliation: St John of God Subiaco Hospital, 12 Salvado Rd, Subiaco, WA 6008, Australia. Electronic address: Jason@womencentre.com.au.
authors.forename: Jason Jit-Sun
authors.initials: JJ
authors.lastname: Tan
authors.affiliation: Women Centre, 2 McCourt St, West Leederville, WA 6007, Australia. Electronic address: Helena@relate-sexology.com.au.
authors.forename: Helena
authors.initials: H
authors.lastname: Green
authors.affiliation: St John of God Subiaco Hospital, 12 Salvado Rd, Subiaco, WA 6008, Australia. Electronic address: Paul.Cohen@sjog.org.au.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000368:Aged; D000728:Androgens / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005833:Genital Neoplasms, Female / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects* / Q000379:methods*; D015995:Prevalence; D058994:Salpingectomy / Q000009:adverse effects* / Q000379:methods*; D012735:Sexual Dysfunction, Physiological / Q000097:blood / Q000209:etiology*; D020018:Sexual Dysfunctions, Psychological / Q000097:blood / Q000209:etiology*; D013739:Testosterone / Q000097:blood
chemical_list: D000728:Androgens; D013739:Testosterone
keywords: Androgen levels; BRCA1; BRCA2; Breast cancer; Female sexual dysfunction; Female sexual function; Hypoactive sexual desire disorder; Lynch syndrome; Ovarian cancer; Prophylactic oophorectomy; Risk-reducing salpingo-oophorectomy