title: Effects of simvastatin and atorvastatin on biochemical and hematological markers in patients with risk of cardiovascular diseases.
abstract: OBJECTIVE
  This study aimed to investigate the effects of simvastatin (SVS) and atorvastatin (AVS) on the biochemical and hematological markers in patients with risk of cardiovascular diseases.
  
  
  METHODS
  One hundred and fifty outpatients were enrolled from the Department of Cardiology. Patients were treated with AVS or SVS. The lipids and hematological parameters were measured at baseline and after 4-week treatment, and the risk factors of cardiovascular diseases were recorded.
  
  
  RESULTS
  After 4-week treatment, the lipids significantly changed. However, for hematological parameters, only mean platelet volume (MPV) significantly decreased after statins treatment (SVS: t = 68.748, P = 0.000; AVS: t = 39.472, P = 0.000), and the extent of decline was similar between SVS group and AVS group (t = 1.063, P = 0.289). There were no correlations between MPV and lipids. SVS and AVS had comparable effects on the lipid parameters after 4-week treatment, and there were no significant correlations of ΔMPV with the Δtotal cholesterol, Δhigh density lipoprotein-cholesterol, Δlow density lipoprotein-cholesterol, Δtriglyceride, Δapolipoproteint A1, Δapolipoproteint B and Δlipoproteint (a) after treatments (all P > 0.05).
  
  
  CONCLUSIONS
  After statins treatment, the lipids significantly change; only MPV significantly decreases among hematological parameters, but it has no relationship with lipids reduction. The synthetic atorvastatin has similar effects to native simvastatin in the management of patients with risk for cardiovascular diseases.
authors.affiliation: Department of General Surgery, Mianyang Central Hospital Sichuan 621000, China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Xian-Yu
authors.affiliation: Department of Laboratory Medicine, Mianyang Central Hospital Sichuan 621000, China.
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Feng
authors.affiliation: Department of Pharmacy, Mianyang Central Hospital Sichuan 621000, China.
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Department of Laboratory Medicine, Mianyang Central Hospital Sichuan 621000, China.
authors.forename: Yu-Wei
authors.initials: YW
authors.lastname: Yang
keywords: Statin; blood; lipid; mean platelet volume