title: Fertility Issues in Disorders of Sex Development.
abstract: Fertility potential should be considered by the multidisciplinary team when addressing gender assignment, surgical management, and patient and family counselling of individuals with disorders of sex development. In 46,XY individuals, defects of gonadal differentiation or androgen or anti-Müllerian hormone synthesis or action result in incomplete or absent masculinization. In severe forms, raised as females, motherhood is possible with oocyte donation if Müllerian ducts have developed. In milder forms, raised as males, azoospermia or oligospermia are frequently found, however paternity has been reported. Most 46,XX patients with normal ovarian organogenesis are raised as females, and fertility might be possible after treatment.
authors.affiliation: Servicio de Endocrinología, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Combate de los Pozos 1881, Buenos Aires C1245AAM, Argentina.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Guercio
authors.affiliation: Servicio de Endocrinología, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Combate de los Pozos 1881, Buenos Aires C1245AAM, Argentina.
authors.forename: Mariana
authors.initials: M
authors.lastname: Costanzo
authors.affiliation: CONICET - FEI - División de Endocrinología, Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), Hospital de Niños Ricardo Gutiérrez, Gallo 1330, Buenos Aires C1425EFD, Argentina.
authors.forename: Romina P
authors.initials: RP
authors.lastname: Grinspon
authors.affiliation: CONICET - FEI - División de Endocrinología, Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), Hospital de Niños Ricardo Gutiérrez, Gallo 1330, Buenos Aires C1425EFD, Argentina; Departamento de Histología, Biología Celular, Embriología y Genética, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires C1121ABG, Argentina. Electronic address: rodolforey@cedie.org.ar.
authors.forename: Rodolfo A
authors.initials: RA
authors.lastname: Rey
mesh_terms: D012734:Disorders of Sex Development / Q000150:complications*; D006801:Humans; D007246:Infertility / Q000209:etiology*
keywords: AMH; Ambiguous genitalia; Androgens; Aromatase; Gonadal dysgenesis; Hypospadias; Müllerian remnants; Ovotestis