title: The Effect of Preventive Immunization on the Incidence of Allergic Conditions.
abstract: The purpose of this study was to assess the effect of preventive immunization on the incidence of allergies in Poland. 18,617 (53.8% female, 24.2% 6-7 years old, 25.4% 13-14 years old, 50.4% 20-44 years old) were selected by stratified cluster sampling method in 8 cities and 1 rural area. 4783 of whom underwent objective outpatient screening assessments. Study subjects were evaluated for any association between preventive immunization against rubella, measles, typhoid fever, smallpox and incidence of atopic dermatitis, allergic rhinitis, and asthma. There was no increased risk of allergy incidence in the majority of vaccinated subjects against rubella, measles, typhoid fever, or smallpox (OR from 0.42 (p<0.0001) to 1.34 (p<0.0001) with 95% CI from 0.27-0.65 to 1.19-1.50). Slightly increased risk of asthma was after vaccination against typhoid (OR=1.27; p<0.0001) and smallpox (OR=1.21; p=0.02). The risk of atopic dermatitis (AD) was also evaluated following vaccination against rubella (OR=1.34; p<0.0001), typhoid (OR=1.13; p=0.005), varicella (OR=1.18; p=0.003); rhinitis and AR following vaccination against measles (respectively OR=1.22; p<0.0005 and OR =1.21; p=0.0002). No higher risk of allergic diseases was demonstrated in vaccinated individuals diagnosed by doctor in an outpatient setting. These data do not demonstrate a causal relationship between vaccinations and allergic conditions.
authors.affiliation: Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Dulny
authors.affiliation: Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Poland.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Sybilski
authors.affiliation: Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Zalewska
authors.affiliation: Department of Epidemiology and Health Promotion, Institute of Rheumatology, Warsaw, Poland.
authors.forename: Filip
authors.initials: F
authors.lastname: Raciborski
authors.affiliation: Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Komorowski
authors.affiliation: Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Piekarska
authors.affiliation: Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Lipiec
authors.affiliation: Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Poland.
authors.forename: Bolesław
authors.initials: B
authors.lastname: Samoliński
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000209:etiology; D015994:Incidence; D008297:Male; D014611:Vaccination / Q000009:adverse effects*
keywords: Allergy; Immunization; Measles; Rubella; Smallpox; Vaccination