title: Correlation of macrophage inflammatory protein-1α single gene polymorphisms with the susceptibility to pigeon breeder's lung in chinese uygur population.
abstract: OBJECTIVE
  To investigate the correlation of macrophage inflammatory protein-1α (MIP-1α) gene single nucleotide polymorphisms (SNP) with the susceptibility to pigeon breeder's lung (PBL) in Chinese Uygur population.
  
  
  METHODS
  A total of 92 Uygur from Xinjiang, China were enrolled in the study. Among them, there were 32 patients with PBL, 30 negative controls with history of exposure to pigeons and 30 normal controls without pigeons contact. SNP genotyping for 24 SNPs of MIP-1α were performed.
  
  
  RESULTS
  Genotype distribution of MIP-1α SNPs rs1049191, rs1049195, rs3210166, rs1130374 and rs5029407 were significantly different among the three groups (P<0.05).
  
  
  CONCLUSIONS
  MIP-1α SNPs rs1049191, rs1049195, rs3210166, rs1130374 and rs5029407 might have correlation with the susceptibility to pigeon breeder's lung in Chinese Uygur population.
authors.affiliation: Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001, China.
authors.forename: Wenyi
authors.initials: W
authors.lastname: Wang
authors.affiliation: Beijing Chaoyang Hospital Beijing, China.
authors.forename: Baosen
authors.initials: B
authors.lastname: Pang
keywords: Pigeon breeder’s lung; macrophage inflammatory protein 1α; single nucleotide polymorphism; susceptibility; uygur