title: A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment.
abstract: A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound 1 in cancer treatment.
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors.forename: Seoung Rak
authors.initials: SR
authors.lastname: Lee
authors.affiliation: College of Pharmacy, CHA University, Pocheon 487-010, Republic of Korea.
authors.forename: Kiwon
authors.initials: K
authors.lastname: Jung
authors.affiliation: Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong 369-873, Republic of Korea.
authors.forename: Hyung Jun
authors.initials: HJ
authors.lastname: Noh
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors.forename: Yong Joo
authors.initials: YJ
authors.lastname: Park
authors.affiliation: College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.
authors.forename: Hye Lim
authors.initials: HL
authors.lastname: Lee
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
authors.affiliation: College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea. Electronic address: kkang@gachon.ac.kr.
authors.forename: Ki Sung
authors.initials: KS
authors.lastname: Kang
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. Electronic address: khkim83@skku.edu.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001487:Basidiomycota / Q000737:chemistry* / Q000378:metabolism; D002554:Cerebrosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D018374:LLC-PK1 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D018919:Neovascularization, Physiologic / Q000187:drug effects; D013552:Swine
chemical_list: D002554:Cerebrosides; C000610145:cerebroside E; D000110:Acetylcholinesterase
keywords: Angiogenesis; Cerebroside; Hericiaceae; Hericium erinaceus; Nephrotoxicity