title: The Relationship Among Oxidative and Anti-Oxidative Parameters and Myeloperoxidase in Subjects With Obstructive Sleep Apnea Syndrome.
abstract: BACKGROUND
  Obstructive sleep apnea (OSA) is a highly prevalent breathing disorder in sleep. It is characterized by intermittent hypoxia leading to hypoxemia, hypercapnia, sleep fragmentation, and increased respiratory efforts. We evaluated the relationship between OSA and myeloperoxidase activity, the oxidative stress index (OSI), total anti-oxidative capacity (TAC), and total oxidative capacity (TOC).
  
  
  METHODS
  A total of 70 consecutive subjects (mean age ± SD: 51.7 ± 11.7 y) were diagnosed with OSA after a night polysomnography recording between January 2014 and June 2014 consecutively. The subjects in the OSA group were divided according to the severity of the disease into three subgroups, consisting of 11 mild, 17 moderate OSA, and 22 severe OSA subjects. Twenty subjects with simple snoring were considered as the control group.
  
  
  RESULTS
  We included a total of 70 subjects: 50 with OSA (11 subjects 6.9% mild, 17 subjects 24.7% moderate, and 22 subjects 68.5% severe) and 20 subjects with simple snoring as control cases. The mean age of the mild OSA subjects was 44.5 ± 11.7 y, moderate OSA subjects' mean age was 52.5 ± 11.9 y, and severe OSA subjects' mean age was 52.1 ± 10.1 y; 54.2% were male. There were statistically significant differences among the 4 groups' OSI, TAC, and TOC levels, but there was no statistically significant difference between the other values. The mean myeloperoxidase, TOC, OSI, and TAC levels were 55 ± 12, 61.2 ± 21.1, 3.04 ± 1.04, and 2.03 ± 0.4 in the mild OSA group; 58.7 ± 17.2, 60 ± 18.9, 3.05 ± 1, and 2 ± 0.33 in the moderate OSA group; 56.6 ± 17.9, 52.1 ± 17.9, 2.7 ± 0.76, and 1.94 ± 0.24 in the severe OSA group; and 49.8 ± 12.5, 54.3 ± 16.4, 3.08 ± 0.88, and 1.78 ± 0.26 in the control group, respectively.
  
  
  CONCLUSIONS
  In our study, there were no differences in studied parameters between control and OSA groups. Furthermore, our low number of cases was a restrictive factor. Further studies should be undertaken to clarify this relation.
authors.affiliation: Pulmonary Medicine Department, Yuzuncu Yıl University, Van drahmetarisoy@gmail.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Arısoy
authors.affiliation: Pulmonary Medicine Department, Yuzuncu Yıl University, Van.
authors.forename: Selami
authors.initials: S
authors.lastname: Ekin
authors.affiliation: Pulmonary Medicine Department, Yuzuncu Yıl University, Van.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Sertogullarindan
authors.affiliation: Pulmonary Medicine Department, Yuzuncu Yıl University, Van.
authors.forename: Hulya
authors.initials: H
authors.lastname: Gunbatar
authors.affiliation: Pulmonary Medicine Department, Yuzuncu Yıl University, Van.
authors.forename: Aysel
authors.initials: A
authors.lastname: Sunnetcioglu
authors.affiliation: Biochemistry Department, Harran University, Şanlıurfa.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Biochemistry Department, Harran University, Şanlıurfa.
authors.forename: Hatice
authors.initials: H
authors.lastname: Sezen
authors.affiliation: Pulmonary Medicine Department, Yuzuncu Yıl University, Van.
authors.forename: Selvi
authors.initials: S
authors.lastname: Asker
authors.affiliation: Otorhinolaringology Department, Yuzuncu Yıl University, Van.
authors.forename: Mahfuz
authors.initials: M
authors.lastname: Turan
authors.affiliation: Pulmonary Medicine Department, Private Lokman Hekim Hospital, Van, Turkey.
authors.forename: Hanifi
authors.initials: H
authors.lastname: Yildiz
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood*; D017286:Polysomnography; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000201:enzymology; D012913:Snoring / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D009195:Peroxidase
keywords: obstructive; oxidative stress; peroxidase; sleep apnea