title: Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer.
abstract: There is increasing evidence suggesting that establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) was involved in tumorigenesis. However, its role in bladder cancer remains unclear. In this study, we aimed to study the clinical correlation and biological significance of ESCO1 in bladder cancer. Our results showed that ESCO1 was significantly over-expressed in bladder cancer tissues compared with that in adjacent normal tissues. And, increased ESCO1 expression was significantly associated with higher grade (P < 0.001), higher tumor stage (P = 0.014), and multifocality (P = 0.042). Kaplan-Meier analysis and Cox proportional hazards model were performed to determine the prognostic significance of ESCO1, and the results showed that ESCO1 is a useful prognostic marker for bladder cancer patients. Moreover, we found that ESCO1 knockdown inhibited the growth, migration, and invasion of bladder cancer cells. In conclusion, our findings indicated that ESCO1 may play an important role in human bladder cancer, and ESCO1 might serve as a novel target and prognosis factor for human bladder cancer.
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Shiying
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Jianye
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Gaobiao
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Mu
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Jingmin
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Jizhang
authors.initials: J
authors.lastname: Xing
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Yao
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Di
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Lv
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Hong
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. Guoheqing777@163.com.
authors.forename: Heqing
authors.initials: H
authors.lastname: Guo
mesh_terms: D000123:Acetyltransferases / Q000096:biosynthesis* / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D000123:Acetyltransferases; C479413:ESCO1 protein, human
keywords: Bladder cancer; Carcinogenesis; Chromosome instability gene; ESCO1; Prognostic factor