title: Research progress and prospects of markers for liver cancer stem cells.
abstract: Liver cancer is a common malignancy and surgery is the main treatment strategy. However, the prognosis is still poor because of high frequencies of postoperative recurrence and metastasis. In recent years, cancer stem cell (CSC) theory has evolved with the concept of stem cells, and has been applied to oncological research. According to cancer stem cell theory, liver cancer can be radically cured only by eradication of liver cancer stem cells (LCSCs). This notion has lead to the isolation and identification of LCSCs, which has become a highly researched area. Analysis of LCSC markers is considered to be the primary method for identification of LCSCs. Here, we provide an overview of the current research progress and prospects of surface markers for LCSCs.
authors.affiliation: Cheng-Pei Zhu, An-Qiang Wang, Hao-Hai Zhang, Xue-Shuai Wan, Xiao-Bo Yang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Cheng-Pei
authors.initials: CP
authors.lastname: Zhu
authors.affiliation: Cheng-Pei Zhu, An-Qiang Wang, Hao-Hai Zhang, Xue-Shuai Wan, Xiao-Bo Yang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: An-Qiang
authors.initials: AQ
authors.lastname: Wang
authors.affiliation: Cheng-Pei Zhu, An-Qiang Wang, Hao-Hai Zhang, Xue-Shuai Wan, Xiao-Bo Yang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Hao-Hai
authors.initials: HH
authors.lastname: Zhang
authors.affiliation: Cheng-Pei Zhu, An-Qiang Wang, Hao-Hai Zhang, Xue-Shuai Wan, Xiao-Bo Yang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Xue-Shuai
authors.initials: XS
authors.lastname: Wan
authors.affiliation: Cheng-Pei Zhu, An-Qiang Wang, Hao-Hai Zhang, Xue-Shuai Wan, Xiao-Bo Yang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Yang
authors.affiliation: Cheng-Pei Zhu, An-Qiang Wang, Hao-Hai Zhang, Xue-Shuai Wan, Xiao-Bo Yang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Chen
authors.affiliation: Cheng-Pei Zhu, An-Qiang Wang, Hao-Hai Zhang, Xue-Shuai Wan, Xiao-Bo Yang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Zhao
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis; D058985:Side-Population Cells / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: CD90; Epithelial cell adhesion molecule; Hepatocellular carcinoma; Liver cancer stem cells; Surface markers