title: Corpus Callosum Pathology as a Potential Surrogate Marker of Cognitive Impairment in Diffuse Axonal Injury.
abstract: Diffuse axonal injury is a major form of traumatic brain injury. Neuropsychological assessments and high-resolution structural MRI were conducted using T1-weighted and diffusion tensor imaging. This study included 10 patients with diffuse axonal injury (all men, mean age 30.8±10.5 years) and 12 age- and sex-matched normal control participants. Patients with diffuse axonal injury had widespread volume reductions and lower fractional anisotropy in the corpus callosum (CC) compared with controls. Furthermore, cognitive processing speed was associated with reductions in white matter volume and fractional anisotropy in the CC. These findings suggest that CC pathology may be a potential surrogate marker of the cognitive deficits in these patients.
authors.affiliation: From the Dept. of Psychiatry (SU, KU, GS, WY, TM) and the Human Brain Research Center (TA, HF), Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Shiho
authors.initials: S
authors.lastname: Ubukata
authors.affiliation: From the Dept. of Psychiatry (SU, KU, GS, WY, TM) and the Human Brain Research Center (TA, HF), Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Ueda
authors.affiliation: From the Dept. of Psychiatry (SU, KU, GS, WY, TM) and the Human Brain Research Center (TA, HF), Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Genichi
authors.initials: G
authors.lastname: Sugihara
authors.affiliation: From the Dept. of Psychiatry (SU, KU, GS, WY, TM) and the Human Brain Research Center (TA, HF), Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Walid
authors.initials: W
authors.lastname: Yassin
authors.affiliation: From the Dept. of Psychiatry (SU, KU, GS, WY, TM) and the Human Brain Research Center (TA, HF), Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Aso
authors.affiliation: From the Dept. of Psychiatry (SU, KU, GS, WY, TM) and the Human Brain Research Center (TA, HF), Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
authors.affiliation: From the Dept. of Psychiatry (SU, KU, GS, WY, TM) and the Human Brain Research Center (TA, HF), Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Murai
mesh_terms: D000328:Adult; D015415:Biomarkers; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology*; D020833:Diffuse Axonal Injury / Q000150:complications / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers