title: Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy.
abstract: CONCLUSIONS
  The prevalence of low-tone hearing loss (LTHL) is significantly high in spinocerebellar degeneration (SCD) with cerebellar predominance, including multiple-system atrophy C (MSA-C) and cortical cerebellar atrophy (CCA).
  
  
  OBJECTIVE
  This study aimed to test the hypothesis that SCD with cerebellar predominance, MSA-C and CCA may cause auditory symptoms.
  
  
  METHODS
  The shape and threshold of pure-tone audiograms were evaluated for MSA-C (n = 47; mean (± SD) age, 61.6 ± 8.9 years), CCA (n = 16; 62.8 ± 9.5 years), and age-matched controls (n = 169; 62.5 ± 10.7 years). To differentiate specific hearing loss for MSA-C and CCA from presbycusis, the shape of audiograms was examined based on previously established audiological criteria.
  
  
  RESULTS
  When audiogram shape was defined according to audiological criteria, the odds ratio for LTHL in SCD compared to controls was 2.492 (95% confidence interval (CI) = 1.208-5.139; p < 0.05, Pearson's Chi-square test) in MSA-C and 2.194 (95% CI = 0.709-6.795) in CCA. When the selection of audiogram shape according to these criteria was verified by three certified audiologists, odds ratios for LTHL in MSA-C and CCA were 3.243 (95% CI = 1.320-7.969) and 3.692 (95% CI = 1.052-12.957), respectively, significantly higher than in controls.
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Omichi
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Maeda
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Sugaya
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kataoka
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Kariya
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Nagayasu
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakagawa
authors.affiliation: b Department of Neurology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Yamashita
authors.affiliation: b Department of Neurology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Abe
authors.affiliation: a Department of Otolaryngology - Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nishizaki
mesh_terms: D000328:Adult; D000368:Aged; D001299:Audiometry; D005260:Female; D034381:Hearing Loss / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications* / Q000503:physiopathology; D012189:Retrospective Studies; D013132:Spinocerebellar Degenerations / Q000150:complications* / Q000503:physiopathology
keywords: Audiogram configuration; cortical cerebellar atrophy; low-tone hearing loss; multiple-system atrophy C; sensorineural hearing loss; spinocerebellar degeneration