title: Antidiabetic effect of honey feeding in noise induced hyperglycemic rat: involvement of oxidative stress.
abstract: OBJECTIVE
  In this study the effect of oral administration of honey on serum glucose, lipids, stress oxidative markers, and morphology of langerhans islets in noise induced hyperglycemic rats was investigated.
  
  
  METHODS
  Male Wistar rats were divided into control, hyperglycemic, honey treated control, and honey treated hyperglycemic groups. For induction of hyperglycemia, noise stress was used. Serum glucose, triglyceride (TG), total cholesterol, low density lipoprotein (LDL), and high density lipoprotein (HDL)-cholesterol levels were determined before the study and at 4(th) and 8(th) weeks after the study. Markers of oxidative stress in brain were also measured. Morphology of langerhans islets in four groups was evaluated using Gomori staining method.
  
  
  RESULTS
  Treatment of noise induced hyperglycemic rats with honey produced a hypoglycemic effect and appropriate changes regarding serum lipids in treated diabetic group at 4(th) and 8(th) weeks as compared to the control group. Meanwhile, honey treatment significantly ameliorated the increased malondialdehyde (MDA) content and reduced the activity of superoxide dismutase (SOD) in brain. Histology of langerhans islets in hyperglycemic group showed a lower number and granularity of beta cells; honey treatment produced beneficial change in this respect.
  
  
  CONCLUSIONS
  Oral administration of honey in experimental model of diabetes showed a significant hypoglycemic effect and led to appropriate changes in serum lipid profiles.
authors.affiliation: Deptartment of Biology, Basic Sciences Faculty, Sciences and Researches, Azad University, Tehran, Iran.
authors.forename: Saiedeh
authors.initials: S
authors.lastname: Arabmoazzen
authors.affiliation: Deptartment of Physiology, Physiology Research Center, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Sarkaki
authors.affiliation: Deptartment of Anatomy, Physiology Research Center, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Saki
authors.affiliation: Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mirshekar
keywords: Beta cell; Diabetes mellitus; Glucose; Honey; Lipid; Noise; Rat