title: Fine particulate matter in acute exacerbation of COPD.
abstract: Chronic obstructive pulmonary disease (COPD) is a common airway disorder. In particular, acute exacerbations of COPD (AECOPD) can significantly reduce pulmonary function. The majority of AECOPD episodes are attributed to infections, although environmental stress also plays a role. Increasing urbanization and associated air pollution, especially in developing countries, have been shown to contribute to COPD pathogenesis. Elevated levels of particulate matter (PM) in polluted air are strongly correlated with the onset and development of various respiratory diseases. In this review, we have conducted an extensive literature search of recent studies of the role of PM2.5 (fine PM) in AECOPD. PM2.5 leads to AECOPD via inflammation, oxidative stress (OS), immune dysfunction, and altered airway epithelial structure and microbiome. Reducing PM2.5 levels is a viable approach to lower AECOPD incidence, attenuate COPD progression and decrease the associated healthcare burden.
authors.affiliation: Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center Columbus, OH, USA ; Department of Pulmonary Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai, China ; Shanghai Key Laboratory of Meteorology and Health, Pudong Meteorological Service Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ni
authors.affiliation: Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center Columbus, OH, USA ; Interdisciplinary Biophysics Program, The Ohio State University Columbus, OH, USA.
authors.forename: Chia-Chen
authors.initials: CC
authors.lastname: Chuang
authors.affiliation: Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center Columbus, OH, USA ; Interdisciplinary Biophysics Program, The Ohio State University Columbus, OH, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zuo
keywords: AECOPD; PM2.5; alveolar macrophages; inflammation; oxidative stress