title: The Minimum Clinically Important Difference in the Repeatable Battery for the Assessment of Neuropsychological Status.
abstract: OBJECTIVE
  There is no established minimum clinically important difference (MCID) for the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) index and total scale scores. This study aimed to estimate the MCID for the RBANS index scores and total scale score.
  
  
  METHODS
  Participants included 1,856 ethnic Chinese, older adults. Distribution- and anchor-based methods were used to estimate values for the MCID. Distribution-based estimates were calculated as the standard error of measurement (SEM) and .5 standard deviations (SD). For anchor-based estimates, we compared RBANS scores between the clinical dementia rating (CDR) scale no dementia and very mild dementia groups and between the clinical assessment of dementia (CAD) cognitively normal and mild cognitive impairment groups using regression models adjusting for demographic characteristics.
  
  
  RESULTS
  Estimates from the CDR anchor were 7.79, 8.63, 10.74, 9.74, 5.61, and 3.77 for the total scale score, language, immediate memory, delayed memory, visuospatial/constructional, and the attention index, respectively. Estimates from the distribution-based methods were similar to the estimates based on the CDR, except for the language and attention indexes. Estimates from the CAD anchor were larger.
  
  
  CONCLUSIONS
  We estimated the MCID for the total scale score, language, immediate memory, delayed memory, visuospatial/constructional, and attention indexes of the RBANS as 8, 9, 10, 10, 6, and 4 points, respectively. These estimates are best suited to discriminate between patient groups, for example, in a clinical trial setting. Further research is needed using longitudinal data to assess their applicability to assess within patient differences.
authors.affiliation: a Biostatistics Department , Singapore Clinical Research Institute , Singapore , Singapore.
authors.forename: Rachel
authors.initials: R
authors.lastname: Phillips
authors.affiliation: b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore.|c Department of Psychological Medicine , National University of Singapore , Singapore , Singapore.
authors.forename: Gao
authors.initials: G
authors.lastname: Qi
authors.affiliation: b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore.|d Department of Psychology , National University of Singapore , Singapore , Singapore.
authors.forename: Simon Lowes
authors.initials: SL
authors.lastname: Collinson
authors.affiliation: b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore.|c Department of Psychological Medicine , National University of Singapore , Singapore , Singapore.
authors.forename: Audrey
authors.initials: A
authors.lastname: Ling
authors.affiliation: b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore.|c Department of Psychological Medicine , National University of Singapore , Singapore , Singapore.
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.affiliation: e Centre for Quantitative Medicine , Duke-National University of Singapore Graduate Medical School , Singapore , Singapore.|f Department of International Health , University of Tampere , Tampere , Finland.
authors.forename: Yin Bun
authors.initials: YB
authors.lastname: Cheung
authors.affiliation: b Gerontological Research Programme, Faculty of Medicine , National University of Singapore , Singapore , Singapore.|c Department of Psychological Medicine , National University of Singapore , Singapore , Singapore.
authors.forename: Tze-Pin
authors.initials: TP
authors.lastname: Ng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001288:Attention; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000523:psychology*; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology*; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D011594:Psychometrics; D012094:Repression, Psychology; D013028:Space Perception
keywords: Chinese.; Elderly/geriatrics/aging; Mild cognitive impairment; Minimum clinically important difference; Neuropsychological test