title: Unique roles played by Acid-sensing ion channel 2.
abstract: The discovery of Acid-sensing ion channels (ASICs) provided us the theoretical basis to understand the pathological acidic environment. They belong to the degenerin/epithelial Na+channel family and function once extracellular pH decreases to a certain level, and this characteristic make them spotlights in the regulation or response of pH change. As a regulatory system, keeping the intra- and extra-balance seems to be significant for ASICs, in which ASIC2 plays an important role. We surprisingly noticed that ASIC2 owns some distinctive properties, including its inter-system regulation, specific distribution and transporting patterns, influence on cell migration and the unique role in mechanosensitivity. Therefore, to conclude the functions and characterisitics of ASIC2 indeed assist the understanding of interaction among ASICs subunits and the regulation from extracellular environment to ASICs.
authors.affiliation: a Dept. of Orthopedic Surgery , Qilu Hospital, Shandong University . West Wenhua Road, No. 107, Ji'nan, Shandong Province , P.R. China . Zip code: 250012.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Guo
authors.affiliation: b Dept. of Gynaecology and Obstetrics , Qilu Hospital, Shandong University . West Wenhua Road, No. 107, Ji'nan, Shandong Province , P.R. China. Zip code: 250012.
authors.forename: Jingying
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Dept. of Orthopedic Surgery , Qilu Hospital, Shandong University . West Wenhua Road, No. 107, Ji'nan, Shandong Province , P.R. China . Zip code: 250012.
authors.forename: Jingkun
authors.initials: J
authors.lastname: Li
authors.affiliation: a Dept. of Orthopedic Surgery , Qilu Hospital, Shandong University . West Wenhua Road, No. 107, Ji'nan, Shandong Province , P.R. China . Zip code: 250012.
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
authors.affiliation: a Dept. of Orthopedic Surgery , Qilu Hospital, Shandong University . West Wenhua Road, No. 107, Ji'nan, Shandong Province , P.R. China . Zip code: 250012.
authors.forename: Nie
authors.initials: N
authors.lastname: Lin
keywords: Acid-sensing ion channel 2; cell migration; cellular distribution pattern; mechanosensitivity; regulatory system