title: From mice to men: Murine models of colorectal cancer for use in translational research.
abstract: Colorectal cancer (CRC) is the third most common carcinoma worldwide and despite advances in treatment, survival for patients with metastatic disease remains poor. With nearly 50% of patients developing metastases, in vivo investigation is essential to improve outcomes for these patients and numerous murine models of CRC have been developed to allow the study of chemoprevention and chemotherapy, in addition to improving our understanding of the pathogenesis of CRC. Selecting the most appropriate murine model for a specific application will maximize the conversion of potential therapies from the laboratory to clinical practice and requires an understanding of the various models available. This review will provide an overview of the murine models currently used in CRC research, discussing the limitations and merits of each and their most relevant application. It is aimed at the developing researcher, acting as a guide to prompt further reading in planning a specific study.
authors.affiliation: Institute of Translational Medicine, University of Liverpool, United Kingdom. Electronic address: jpevans@liverpool.ac.uk.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Evans
authors.affiliation: Institute of Translational Medicine, University of Liverpool, United Kingdom; Department of Colorectal Surgery, Countess of Chester Hospital NHS Foundation Trust, United Kingdom.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sutton
authors.affiliation: Institute of Translational Medicine, University of Liverpool, United Kingdom.
authors.forename: Boleslaw K
authors.initials: BK
authors.lastname: Winiarski
authors.affiliation: Liverpool Hepatobiliary Unit, Aintree University Hospital, United Kingdom.
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Fenwick
authors.affiliation: Liverpool Hepatobiliary Unit, Aintree University Hospital, United Kingdom.
authors.forename: Hassan Z
authors.initials: HZ
authors.lastname: Malik
authors.affiliation: Department of Colorectal Surgery, Countess of Chester Hospital NHS Foundation Trust, United Kingdom.
authors.forename: Dale
authors.initials: D
authors.lastname: Vimalachandran
authors.affiliation: Institute of Translational Medicine, University of Liverpool, United Kingdom.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Tweedle
authors.affiliation: Institute of Translational Medicine, University of Liverpool, United Kingdom.
authors.forename: Eithne
authors.initials: E
authors.lastname: Costello
authors.affiliation: Institute of Translational Medicine, University of Liverpool, United Kingdom; Clatterbridge Cancer Centre, Bebington, Wirral, United Kingdom.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Palmer
authors.affiliation: Institute of Translational Medicine, University of Liverpool, United Kingdom.
authors.forename: B Kevin
authors.initials: BK
authors.lastname: Park
authors.affiliation: Institute of Translational Medicine, University of Liverpool, United Kingdom.
authors.forename: Neil R
authors.initials: NR
authors.lastname: Kitteringham
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D057170:Translational Research, Biomedical
keywords: Colorectal cancer; Metastases; Murine models; Preclinical studies; Small animal imaging