title: Chimeric antigen receptor T cell therapy: 25years in the making.
abstract: Chimeric antigen receptor (CAR) T cell therapy of cancer is generating enormous enthusiasm. Twenty-five years after the concept was first proposed, major advances in molecular biology, virology, and good manufacturing practices (GMP)-grade cell production have transformed antibody-T cell chimeras from a scientific curiosity to a fact of life for academic cellular immunotherapy researchers and, increasingly, for patients. In this review, we explain the preclinical concept, outline how it has been translated to the clinic, and draw lessons from the first years of CAR T cell therapy for the practicing clinician.
authors.affiliation: Division of Hematology/Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA. Electronic address: saar.gill@uphs.upenn.edu.
authors.forename: Saar
authors.initials: S
authors.lastname: Gill
authors.affiliation: Division of Hematology/Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.
authors.forename: Marcela V
authors.initials: MV
authors.lastname: Maus
authors.affiliation: Division of Hematology/Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Porter
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000009:adverse effects / Q000379:methods / Q000639:trends; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods / Q000639:trends; D016219:Immunotherapy, Adoptive / Q000009:adverse effects / Q000379:methods / Q000639:trends; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000378:metabolism*; D011993:Recombinant Fusion Proteins; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
chemical_list: D011948:Receptors, Antigen, T-Cell; D011993:Recombinant Fusion Proteins
keywords: Adoptive immunotherapy; Chimeric antigen receptor T cells