title: [Role of Serotonin Transporter Gene in Eating Disorders].
abstract: BACKGROUND
  The serotoninergic system has been implicated in mood and appetite regulation, and the serotonin transporter gene (SLC6A4) is a commonly studied candidate gene for eating disorders. However, most studies have focused on a single polymorphism (5-HTTLPR) in SLC6A4.
  
  
  OBJECTIVE
  We present the studies published on the association between eating disorders (ED) and 5-HTTLPR polymorphism in anorexia nervosa (AN), bulimia nervosa (BN), and eating disorders not otherwise specified (EDNOS).
  
  
  METHODS
  Search of databases: MEDLINE, ISI, and PubMed for SLC6A4 and ED.
  
  
  CONCLUSIONS
  From a review of 37 original articles, it was suggested that carriers of S allele is a risk factor for eating disorders, especially for AN. However, BN did not show any association. Also, BMI, impulsivity, anxiety, depression, and age of onset have been associated with S allele in ED patients.
authors.affiliation: Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México, D.F., México.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hernández-Muñoz
authors.affiliation: Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México, D.F., México. Electronic address: camare@imp.edu.mx.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Camarena-Medellin
keywords: 5-HTTLPR; Anorexia nerviosa; Anorexia nervosa; Bulimia nerviosa; Bulimia nervosa; Gen; Gene; Polimorfismo; Polymorphism; Serotonin; Serotonina