title: Association of various risk factors with chronic lymphocytic leukemia and its cytogenetic characteristics.
abstract: This study aimed to investigate whether occupational and environmental exposures, lifestyle, family, and medical history are associated with chronic lymphocytic leukemia (CLL) risk and its chromosomal abnormalities. The study included 138 CLL cases and 141 age- and sex-matched controls. Information data were collected through in-person interviews from cases and controls. Cytogenetic analysis was performed on CLL bone marrow cells. Positive associations were found between CLL and cancer family history, smoking, pneumonia, and exposure to petroleum, metals, pesticides/chemical fertilizers, detergents, and medical radiation. Chromosome deletions of 11q and 13q were more frequent in patients exposed to pesticides and rubber, respectively. This study investigated for the first time specific risk factors in relation to CLL aberrations and presented positive correlations. Moreover, it indicates the possible involvement of specific occupational and lifestyle risk factors in the onset of CLL.
authors.affiliation: a Laboratory of Health Physics, Radiobiology and Cytogenetics, National Center for Scientific Research (NCSR) "Demokritos," Athens , Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Karakosta
authors.affiliation: a Laboratory of Health Physics, Radiobiology and Cytogenetics, National Center for Scientific Research (NCSR) "Demokritos," Athens , Greece.
authors.forename: Eumorfia-Maria
authors.initials: EM
authors.lastname: Delicha
authors.affiliation: b Second Department of Propedeutic Surgery , School of Medicine, University of Athens, General Hospital "Laiko," Athens , Greece.
authors.forename: Gregory
authors.initials: G
authors.lastname: Kouraklis
authors.affiliation: a Laboratory of Health Physics, Radiobiology and Cytogenetics, National Center for Scientific Research (NCSR) "Demokritos," Athens , Greece.
authors.forename: Kalliopi N
authors.initials: KN
authors.lastname: Manola
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
keywords: CLL risk; Chromosome abnormalities; exposure