title: New Antiglycative Compounds from Cumin (Cuminum cyminum) Spice.
abstract: Cumin (Cuminum cyminum L.), a widely consumed food spice, has been reported to have antiglycative effects in vitro and in vivo, but there is a paucity of data on its bioactive compounds. Herein, we report the isolation and structure elucidation (by NMR, HRESIMS, and CD) of 21 (1-21) compounds from a methanol extract of cumin seeds. The isolates included five new compounds: two sesquiterpenoids, two pairs of monoterpeneoid epimers, and a chalcone, named cuminoids A-E, respectively. The isolates were evaluated for antiglycative effects using the bovine serum albumin-fructose intrinsic fluorescence assay. At equivalent concentrations, several of the isolates, including cuminoids C-E, were more potent inhibitors than the positive control, aminoguanidine, a synthetic antiglycative agent (>50 vs 35%, respectively).
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
authors.forename: Hang
authors.initials: H
authors.lastname: Ma
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
authors.forename: Weixi
authors.initials: W
authors.lastname: Liu
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.|The Key Laboratory of Plant Resources and Chemistry of Arid Zone; State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yuan
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.
authors.forename: Navindra P
authors.initials: NP
authors.lastname: Seeram
mesh_terms: D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D028527:Cuminum / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D064209:Phytochemicals / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry*; D017365:Spices / Q000032:analysis*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D047188:Chalcones; D017127:Glycation End Products, Advanced; D064209:Phytochemicals; D010936:Plant Extracts; D013729:Terpenes
keywords: Cuminum cyminum; advanced glycation endproducts; antiglycative; bioactive; cumin; cuminoids