title: Peroxisome proliferator-activated receptor gamma (PPARG) rs1801282 C>G polymorphism is associated with cancer susceptibility in asians: an updated meta-analysis.
abstract: Peroxisome proliferator-activated receptor gamma (PPARG) is related to inflammation and plays an important role in the development of cancer. PPARG rs1801282 C>G polymorphism might influence the risk of cancer by regulating production of PPARG gene. Hence, a comprehensive meta-analysis was conducted to explore the association of PPARG rs1801282 C>G polymorphism with cancer susceptibility. An extensive search of PubMed and Embase databases for all relevant publications was carried out. A total of 38 publications with 16,844 cancer cases and 23,736 controls for PPARG rs1801282 C>G polymorphism were recruited in our study. Our results indicated that PPARG rs1801282 C>G variants were associated with an increased cancer risk in Asian populations and gastric cancer. In summary, the findings suggest that PPARG rs1801282 C>G polymorphism may play a crucial role in malignant transformation and the development of cancer.
authors.affiliation: Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture Jinghong, Yunnan Province, China.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Fujian Provincial Cancer Hospital Fuzhou, Fujian Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Emergency, Affiliated Jintan People's Hospital of Jiangsu University Jintan, China.
authors.forename: Heping
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Thoracic Surgery, The Union Clinical Medical College of Fujian Medical University Fuzhou, Fujian Province, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Thoracic Surgery, The Union Clinical Medical College of Fujian Medical University Fuzhou, Fujian Province, China.
authors.forename: Mingqiang
authors.initials: M
authors.lastname: Kang
authors.affiliation: Department of Cardiology, The Second Clinical Medical College of Fujian Medical University Quanzhou, Fujian Province, China.
authors.forename: Tianyun
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Medical Oncology, Fujian Provincial Cancer Hospital Fuzhou, Fujian Province, China.
authors.forename: Zengqing
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Cardiothoracic Surgery, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture Jinghong, Yunnan Province, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Ma
keywords: Cancer; meta-analysi; peroxisome proliferator-activated receptor gamma; polymorphism