title: PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries.
abstract: : Pleiotropy is common in the genetic architectures of complex diseases. To the best of our knowledge, no analysis tool has been developed for identifying pleiotropic pathways using multiple genome-wide association study (GWAS) summaries by now. Here, we present PAPA, a flexible tool for pleiotropic pathway analysis utilizing GWAS summary results. The performance of PAPA was validated using publicly available GWAS summaries of body mass index and waist-hip ratio of the GIANT datasets. PAPA identified a set of pleiotropic pathways, which have been demonstrated to be involved in the development of obesity.
  
  
  
  PAPA program, document and illustrative example are available at http://sourceforge.net/projects/papav1/files/
  
  
  
  : fzhxjtu@mail.xjtu.edu.cn
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, People's Republic of China.
authors.forename: Wenyu
authors.initials: W
authors.lastname: Wang
authors.affiliation: Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, People's Republic of China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Guo
authors.affiliation: Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
mesh_terms: D055106:Genome-Wide Association Study; D006801:Humans; D049629:Waist-Hip Ratio