title: The epidemiological characteristics and genetic diversity of dengue virus during the third largest historical outbreak of dengue in Guangdong, China, in 2014.
abstract: OBJECTIVE
  The third largest historical outbreak of dengue occurred during July to December 2014, in 20 of 21 cities of Guangdong, China. The epidemiological and molecular characteristics of the introduction, expansion and phylogeny of the DENV isolates involved in this outbreak were investigated.
  
  
  METHODS
  A combination analyses of epidemiological characteristics and genetic diversity of dengue virus was performed in this study.
  
  
  RESULTS
  In total, 45,236 cases and 6 fatalities were reported. Unemployed individuals, retirees and retailers were the most affected populations. A total of 6024 cases were verified to have DENV infections by nucleic acid detection, of which 5947, 74 and 3 were confirmed to have DENV-1, -2, and -3 infections, respectively. Phylogenetic analyses of DENV-1 isolates were assigned into three genotypes (I, IV, and V). Genotype V was the predominant genotype that likely originated from Singapore. The DENV-2 isolates were assigned to the Cosmopolitan and Asian I genotypes. A unique DENV-3 isolate (genotype III) shared high similarity with isolates obtained from Guangdong in 2013.
  
  
  CONCLUSIONS
  A combination analyses demonstrated the multiple geographical origins of this outbreak, and highlight the importance of early detection, the case management and vector surveillance for preventing further dengue epidemics in Guangdong.
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China.
authors.forename: Jiufeng
authors.initials: J
authors.lastname: Sun
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China.
authors.forename: De
authors.initials: D
authors.lastname: Wu
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China.
authors.forename: Huiqiong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Guan
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China.
authors.forename: Songwu
authors.initials: S
authors.lastname: Cai
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China. Electronic address: kecw1965@aliyun.com.
authors.forename: Changwen
authors.initials: C
authors.lastname: Ke
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China.
authors.forename: Jinyan
authors.initials: J
authors.lastname: Lin
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology* / Q000821:virology*; D003716:Dengue Virus / Q000235:genetics*; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: DENV-1; Dengue virus; Guangdong; Outbreak