title: Low Serum Levels of Uric Acid are Associated With Development of Poststroke Depression.
abstract: Poststroke depression (PSD) is a frequent complication of stroke that has been associated with poorer outcome of stroke patients. This study sought to examine the possible association between serum uric acid levels and the development of PSD.We recruited 196 patients with acute ischemic stroke and 100 healthy volunteers. Serum uric acid levels were tested by uricase-PAP method within 24 hr after admission. Neuropsychological evaluations were conducted at 3-month poststroke. The 17-item Hamilton Depression Scale was used to assess depressive symptoms. Diagnosis of PSD was made in accordance with DSM-IV criteria for depression. Multivariate analyses were conducted using logistic regression models.Fifty-six patients (28.6%) were diagnosed as having PSD at 3 months. PSD patients showed significantly lower levels of uric acid at baseline as compared to non-PSD patients (237.02 ± 43.43 vs 309.10 ± 67.44 μmol/L, t = -8.86, P < 0.001). In multivariate analyses, uric acid levels (≤239.0 and ≥328.1 μmol/L) were independently associated with the development of PSD (OR, 7.76; 95% confidence interval [CI], 2.56-23.47, P < 0.001 and OR, 0.05; 95% CI, 0.01-0.43, P = 0.01, respectively) after adjustment for possible variables.Serum uric acid levels at admission are found to be correlated with PSD and may predict its development at 3 months after stroke.
authors.affiliation: From the Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang (YG, BH, LW, YC, LZ, WR, MY, JH), Beijing HuiLongGuan Hospital, Peking University, Beijing, P.R. China (XZ); and Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX (XZ).
authors.forename: Yingying
authors.initials: Y
authors.lastname: Gu
authors.forename: Bin
authors.initials: B
authors.lastname: Han
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.forename: Yaling
authors.initials: Y
authors.lastname: Chang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Wenwei
authors.initials: W
authors.lastname: Ren
authors.forename: Mengjiao
authors.initials: M
authors.lastname: Yan
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Zhang
authors.forename: Jincai
authors.initials: J
authors.lastname: He
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000150:complications / Q000523:psychology; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000097:blood* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000209:etiology / Q000523:psychology*; D013997:Time Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid