title: Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.
abstract: Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Fukuda
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University , 6-10-14 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Akane
authors.initials: A
authors.lastname: Shojima
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University , 6-10-14 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Nakayama
authors.affiliation: Departmento de Microbiologia y Genetica, Edificio Departamental Lab. 214, Universidad de Salamanca , Campus Miguel de Unamuno, 37007 Salamanca, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Carro
authors.affiliation: Departmento de Microbiologia y Genetica, Edificio Departamental Lab. 214, Universidad de Salamanca , Campus Miguel de Unamuno, 37007 Salamanca, Spain.
authors.forename: Martha E
authors.initials: ME
authors.lastname: Trujillo
mesh_terms: D001173:Arthrobacter / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D053038:Quorum Sensing; D013211:Staphylococcus aureus
chemical_list: D047630:Depsipeptides; C000605883:arthroamide; C560137:turnagainolide A