title: Studying the influence of angiogenesis in in vitro cancer model systems.
abstract: Tumor angiogenesis is a hallmark of cancer that has been identified as a critical component of cancer progression, facilitating rapid tumor growth and metastasis. Anti-angiogenic therapies have exhibited only modest clinical success, highlighting a need for better models that can be used to gain a more thorough understanding of tumor angiogenesis and screen potential therapeutics more accurately. This review explores how recent progress in in vitro cancer and vascular models individually can be applied to the development of in vitro tumor angiogenesis models. Current in vitro tumor angiogenesis models are also discussed, with a focus on aspects of the process that have been successfully recapitulated and opportunities for applying new technologies to expand model complexity to better represent the tumor microenvironment. Continued advances in vascularized tumor models will provide tools to identify novel therapeutic targets and validate their therapeutic benefit.
authors.affiliation: Department of Biomedical Engineering, Duke University, Room 1427, Fitzpatrick CIEMAS, 101 Science Drive, Campus Box 90281, Durham, NC 27708, USA. Electronic address: Laila.roudsari@duke.edu.
authors.forename: Laila C
authors.initials: LC
authors.lastname: Roudsari
authors.affiliation: Department of Biomedical Engineering, Duke University, Room 1427, Fitzpatrick CIEMAS, 101 Science Drive, Campus Box 90281, Durham, NC 27708, USA. Electronic address: Jennifer.l.west@duke.edu.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: West
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D009389:Neovascularization, Pathologic; D009924:Organ Culture Techniques; D023822:Tissue Engineering
keywords: Biomaterials; Extracellular matrix; Microenvironment; Tumor; Tumor angiogenesis; Tumor engineering; Vascular