title: An interactive tool for rapid biventricular analysis of congenital heart disease.
abstract: Cardiac malformations are the most common birth defect. Better interventions in early life have improved mortality for children with congenital heart disease, but heart failure is a significant problem in adulthood. These patients require regular imaging and analysis of biventricular (left and right ventricular) function. In this study, we describe a rapid method to analyse left and right ventricular shape and function from cardiac MRI examinations. A 4D (3D+time) finite element model template is interactively customized to the anatomy and motion of the biventricular unit. The method was validated in 17 patients and 10 ex-vivo hearts. Interactive model updates were achieved through preconditioned conjugate gradient optimization on a multithread system, and by precomputing points predicted from a coarse mesh optimization.
authors.affiliation: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: K
authors.initials: K
authors.lastname: Gilbert
authors.affiliation: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: H-I
authors.initials: HI
authors.lastname: Lam
authors.affiliation: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: B
authors.initials: B
authors.lastname: Pontré
authors.affiliation: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: B R
authors.initials: BR
authors.lastname: Cowan
authors.affiliation: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: C J
authors.initials: CJ
authors.lastname: Occleshaw
authors.affiliation: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: J Y
authors.initials: JY
authors.lastname: Liu
authors.affiliation: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: A A
authors.initials: AA
authors.lastname: Young
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001696:Biomechanical Phenomena; D002648:Child; D005260:Female; D020342:Finite Element Analysis; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008955:Models, Cardiovascular; D066230:Patient-Specific Modeling; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D034561:Sheep, Domestic; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right; D055815:Young Adult
keywords: cardiac MRI; computer-aided diagnosis; congenital heart disease; guide-point modelling; image analysis