title: Potential role of the glycolytic oscillator in acute hypoxia in tumors.
abstract: Tumor acute hypoxia has a dynamic component that is also, at least partially, coherent. Using blood oxygen level dependent magnetic resonance imaging, we observed coherent oscillations in hemoglobin saturation dynamics in cell line xenograft models of head and neck squamous cell carcinoma. We posit a well-established biochemical nonlinear oscillatory mechanism called the glycolytic oscillator as a potential cause of the coherent oscillations in tumors. These data suggest that metabolic changes within individual tumor cells may affect the local tumor microenvironment including oxygen availability and therefore radiosensitivity. These individual cells can synchronize the oscillations in patches of similar intermediate glucose levels. These alterations have potentially important implications for radiation therapy and are a potential target for optimizing the cancer response to radiation.
authors.affiliation: Department of Medical Physics, University of Wisconsin - Madison, Madison, WI 53706, USA.
authors.forename: Leonard Che
authors.initials: LC
authors.lastname: Fru
authors.forename: Erin B
authors.initials: EB
authors.lastname: Adamson
authors.forename: David D
authors.initials: DD
authors.lastname: Campos
authors.forename: Sean B
authors.initials: SB
authors.lastname: Fain
authors.forename: Steven L
authors.initials: SL
authors.lastname: Jacques
authors.forename: Albert J
authors.initials: AJ
authors.lastname: van der Kogel
authors.forename: Kwang P
authors.initials: KP
authors.lastname: Nickel
authors.forename: Chihwa
authors.initials: C
authors.lastname: Song
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Kimple
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kissick
mesh_terms: D000208:Acute Disease; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005947:Glucose / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000473:pathology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000473:pathology*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D010100:Oxygen / Q000378:metabolism*; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured; D059016:Tumor Microenvironment; D023041:Xenograft Model Antitumor Assays
chemical_list: D006454:Hemoglobins; D005947:Glucose; D010100:Oxygen