title: Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy.
abstract: Human immunodeficiency virus (HIV)-1-infected individuals are affected by diseases at rates above those of their HIV-negative peers despite the increased life expectancy of the highly active antiretroviral therapy era. We followed a cohort of approximately 2000 HIV-1-infected patients for 5 years. The most frequent cause of death in this HIV-1-infected cohort was malignancy, with 39% of all classified deaths due to cancer. Among the cancer deaths, B-cell lymphomas were the most commonly seen malignancy, representing 34% of all cancer deaths. These lymphomas were very aggressive with a median survival of <2 months from time of diagnosis.
authors.affiliation: Department of Biochemistry and Molecular Biophysics ; Department of Medicine, Division of Infectious Diseases , Columbia University Medical Center ; Department of Medicine-Division of Infectious Disease , Hofstra North Shore-LIJ School of Medicine , Manhasset.
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Griffin
authors.affiliation: Department of Biochemistry and Molecular Biophysics , Howard Hughes Medical Institute, Columbia University Medical Center , New York, New York.
authors.forename: Michael
authors.initials: M
authors.lastname: Metzger
authors.affiliation: Department of Medicine-Division of Infectious Disease , Hofstra North Shore-LIJ School of Medicine , Manhasset.
authors.forename: Kaitlin
authors.initials: K
authors.lastname: Poeth
authors.affiliation: Department of Medicine-Division of Infectious Disease , Hofstra North Shore-LIJ School of Medicine , Manhasset.
authors.forename: Kathy
authors.initials: K
authors.lastname: Deng
authors.affiliation: Department of Medicine-Division of Infectious Disease , Hofstra North Shore-LIJ School of Medicine , Manhasset.
authors.forename: Arif
authors.initials: A
authors.lastname: Dharsee
authors.affiliation: Department of Medicine-Division of Infectious Disease , Hofstra North Shore-LIJ School of Medicine , Manhasset.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Rico
authors.affiliation: Department of Biochemistry and Molecular Biophysics , Howard Hughes Medical Institute, Columbia University Medical Center , New York, New York.
authors.forename: Joseph
authors.initials: J
authors.lastname: McGowan
keywords: B cell; HIV-1; lymphoma; malignancy; mortality