title: Enzyme encapsulation in zeolitic imidazolate frameworks: a comparison between controlled co-precipitation and biomimetic mineralisation.
abstract: Recent studies have demonstrated that metal-organic frameworks can be employed as protective coatings for enzymes. Two efficient strategies have been reported for the synthesis of such composite materials: biomimetic mineralisation and controlled co-precipitation using polyvinylpyrrolidone. We assessed the relative efficacy of each approach by comparing the thermal stability of encapsulated urease. The resulting data shows that over a range of temperatures biomimetic mineralisation offers superior protection than the co-precipitation method.
authors.affiliation: CSIRO Manufacturing Flagship, Private Bag 10, Clayton South, Victoria 3169, Australia. Paolo.Falcaro@csiro.au.
authors.forename: Kang
authors.initials: K
authors.lastname: Liang
authors.forename: Campbell J
authors.initials: CJ
authors.lastname: Coghlan
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Bell
authors.forename: Christian
authors.initials: C
authors.lastname: Doonan
authors.forename: Paolo
authors.initials: P
authors.lastname: Falcaro
mesh_terms: D032701:Biomimetics / Q000379:methods; D002214:Capsules / Q000737:chemistry*; D011232:Chemical Precipitation; D004355:Drug Stability; D007093:Imidazoles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013696:Temperature; D014510:Urease / Q000737:chemistry*; D017641:Zeolites / Q000737:chemistry*
chemical_list: D002214:Capsules; D007093:Imidazoles; D009942:Organometallic Compounds; D017641:Zeolites; D014510:Urease