title: Synthesis and characterization of ZnFe2O4nanoparticles and its biomedical applications.
abstract: Biomedical applications of ZnFe2O4nanoparticle are preferable among all kinds of ferrites due to the compatibility of Zn2+ions for human bodies. We have followed the soft chemical route to synthesize chitosan and PEG coated ZnFe2O4nanoparticles and also the chitosan-coated-nanoparticles encapsulated with liposome. X-ray diffraction studies by the Mo Kαtarget, showed the formation of single phase spinel structure. The lattice parameter turned out to be 8.48Å and grain size ~ 4.8 nm (± 0.1 nm). Similar particle size was observed by transmission electron microscope analysis. HRTEM studies showed the distinct lattice fringes thus confirming the good crystallinity of the synthesized nanoparticles. M-H curve at room temperature showed the prepared sample was superparamagnetic in nature, which is also confirmed by the doublets of Mössbauer spectroscopy. Relaxivity values (r2) of Chitosan and PEG coated ZnFe2O4nanoparticles are 68 and 76 mM-1s-1respectively. In order to achieve further biocompatibility the chitosan-coated-nanoparticles were encapsulated with liposome. The r2relaxivity was found as 54mM-1s-1. MR images obtained from the in vitro experiments based on phantoms demonstrated good contrast enhancement. Induction heating of bare and coated particles was investigated to reveal the self heating temperature rising properties of ZnFe2O4nanoparticles.
authors.affiliation: Dept. of Diagnostic Radiology, Yale University, U.S., Materials Science Division, Atomic Energy Center, Dhaka, Bangladesh ; Department of Physics, University of Dhaka, Dhaka, Bangladesh.
authors.forename: S Manjura
authors.initials: SM
authors.lastname: Hoque
authors.affiliation: Department of Physics, University of Dhaka, Dhaka, Bangladesh.
authors.forename: Md Sazzad
authors.initials: MS
authors.lastname: Hossain
authors.affiliation: Department of Physics, University of Dhaka, Dhaka, Bangladesh.
authors.forename: Shamima
authors.initials: S
authors.lastname: Choudhury
authors.affiliation: Department of Physics, University of Dhaka, Dhaka, Bangladesh.
authors.forename: S
authors.initials: S
authors.lastname: Akhter
authors.affiliation: Dept. of Diagnostic Radiology, Yale University, U.S., Materials Science Division, Atomic Energy Center, Dhaka, Bangladesh.
authors.forename: F
authors.initials: F
authors.lastname: Hyder
keywords: Hypethermia; Magnetization; Mossbauer spectroscopy; Nuclear Magnetic Resonance; Zinc Ferrite nanoparticle