title: Acute systemic response to intraperitoneal implantation of polypropylene mesh/chitosan-based film composite in pigs.
abstract: OBJECTIVE
  To assess the systemic response of pigs to the intraperitoneal implantation of polypropylene mesh associated with chitosan-based film with a degree of deacetylation of 95%.
  
  
  METHODS
  Blood samples were collected 24 hours before, and two and seven days after surgery. Systemic reactions were evaluated based on white blood cell count, C-reactive protein, and total serum protein, albumin and globulin levels.
  
  
  RESULTS
  The systemic response was proportional to the composite response induced by polypropylene mesh, and the tissue inflammatory response was higher in the PP group (p=0.0033).
  
  
  CONCLUSIONS
  The polypropylene mesh/chitosan-based film composite did not elicit a systemic response in pigs.
authors.affiliation: School of Veterinary Medicine and Zootechny, Universidade Federal de Goiás, Goiania, GO, Brazil.
authors.forename: Apóstolo Ferreira
authors.initials: AF
authors.lastname: Martins
authors.affiliation: School of Veterinary Medicine and Zootechny, UFG, Goiania, GO, Brazil.
authors.forename: Naida Cristina
authors.initials: NC
authors.lastname: Borges
authors.affiliation: School of Veterinary Medicine and Zootechny, UFG, Goiania, GO, Brazil.
authors.forename: Priscila Vaz
authors.initials: PV
authors.lastname: Coutinho
authors.affiliation: School of Veterinary Medicine and Zootechny, UFG, Goiania, GO, Brazil.
authors.forename: Aline Rodrigues
authors.initials: AR
authors.lastname: Lemes
authors.affiliation: School of Veterinary Medicine and Zootechny, UFG, Goiania, GO, Brazil.
authors.forename: Ashbel Schneider da
authors.initials: AS
authors.lastname: Silva
authors.affiliation: School of Veterinary Medicine and Zootechny, UFG, Goiania, GO, Brazil.
authors.forename: Rayssa Kossa
authors.initials: RK
authors.lastname: Barbosa
authors.affiliation: School of Veterinary Medicine and Zootechny, UFG, Goiania, GO, Brazil.
authors.forename: Neusa Margarida
authors.initials: NM
authors.lastname: Paulo
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000210:Acute-Phase Reaction / Q000209:etiology*; D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D048271:Chitosan / Q000627:therapeutic use*; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D007958:Leukocyte Count; D008297:Male; D008422:Materials Testing; D010529:Peritoneal Cavity / Q000601:surgery; D011126:Polypropylenes / Q000627:therapeutic use*; D011897:Random Allocation; D015203:Reproducibility of Results; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis; D013526:Surgical Mesh; D013552:Swine; D013997:Time Factors
chemical_list: D020099:Coated Materials, Biocompatible; D011126:Polypropylenes; D012709:Serum Albumin; D012712:Serum Globulins; D002097:C-Reactive Protein; D048271:Chitosan