title: Antimüllerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause.
abstract: OBJECTIVE
  To study the age-specific distribution of antimüllerian hormone (AMH) and describe the association of AMH with androgenic and metabolic profiles at different ages.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A total of 6,763 Chinese women from birth to menopause.
  
  
  METHODS
  None.
  
  
  METHODS
  Anthropometric parameters (height, weight, and blood pressure), and levels of AMH and testosterone, glucose metabolism, and lipid profiles.
  
  
  RESULTS
  According to the level of AMH, four age phases were established: childhood (0-10 years), adolescence (11-18 years), reproductive age (19-50 years), and advanced age (≥51 years). During childhood and adolescence, AMH levels increased, reaching a peak at 18 years. A decline occurred thereafter during the reproductive-age period until the age of 50 years, and it remained at a low level above 0 onward. We found that AMH was negatively correlated with testosterone in childhood (r = -0.25), but was positively correlated with testosterone and the free androgen index in adolescence (r = 0.30; r = 0.26, respectively) as well as during the reproductive phases (r = 0.28; r = 0.31, respectively). No correlation was observed between AMH and body mass index, fasting blood glucose, fasting insulin, the homeostasis model assessment, total cholesterol, triglycerides, low-density lipoprotein, or high-density lipoprotein at any phase.
  
  
  CONCLUSIONS
  From birth to 18 years, AMH increases, then it declines thereafter, indicating changes of ovarian maintenance. A positive relationship between androgenic profiles and AMH during adolescence and reproductive years implies a synchronism between androgens and ovarian reserve.
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Cui
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Gao
authors.affiliation: Qilu Securities Institute for Financial Studies, Shandong University, Jinan, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.affiliation: Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Geng
authors.affiliation: Reproductive Medical Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Ding
authors.affiliation: Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Qu
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China.
authors.forename: Xiruo
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; Key Laboratory for Reproductive Endocrinology of Ministry of Education, People's Republic of China, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China; Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China. Electronic address: chenzijiang@hotmail.com.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000097:blood*; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D065851:Ovarian Reserve; D010053:Ovary / Q000378:metabolism*; D017698:Postmenopause / Q000097:blood*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids; D013739:Testosterone; D054304:Anti-Mullerian Hormone
keywords: AMH; Age; metabolism; testosterone