title: Effect of Surgical Periodontal Therapy on Serum C-reactive Protein Levels Using ELISA in Both Chronic and Aggressive Periodontitis Patient.
abstract: BACKGROUND
  Periodontitis can be defined as a local inflammatory process which mediates destruction of periodontal tissues & is triggered by bacterial insult. In periodontal infections, the levels of C reactive proteins are elevated as compared to the levels in a periodontally healthy individual. The study was done to determine the relative levels of serum CRP in aggressive, chronic and periodontally healthy subjects and to evaluate the effect of surgical periodontal therapy on serum C-reactive protein levels.
  
  
  METHODS
  Serum samples were collected from 150 participants (50 healthy control patients (non-periodontitis), 50 patients with chronic periodontitis and aggressive periodontitis. Serum C- reactive protein levels were assessed by means of immunoturbidimetric assay at baseline for subjects in all the 3 groups and 3 months after completion of surgical therapy.
  
  
  RESULTS
  The mean baseline C-reactive protein (CRP) concentrations in the Groups I, II and III were 1.65±0.57 mg/L, 3.03±2.14 mg/L and 3.09±2.27 mg/L respectively. After treatment, the mean C-reactive protein (CRP) levels in Groups II and III reduced from 3.03±1.67 mg/L to 1.46±1.67 mg/L and from 3.09±1.21 to 1.43±1.21 mg/L respectively. Similar results were found for probing depth and all indexes in Group II and III after treatment. Also, the mean attachment loss in Groups II and III reduced, so the results were highly significant.
  
  
  CONCLUSIONS
  Successful periodontal treatment results in significant decrease in serum C-reactive protein (CRP) levels in otherwise healthy subjects.
authors.affiliation: Senior Lecturer, Department of Periodontology and Implantology, Mahatma Gandhi Dental College , Mumbai, India .
authors.forename: Bharat
authors.initials: B
authors.lastname: Gupta
authors.affiliation: Assistant Professor, Department of Periodontology and Implantology, Universal College of Dental Sciences , Bhairahawa, Nepal .
authors.forename: Anshul
authors.initials: A
authors.lastname: Sawhney
authors.affiliation: Senior Lecturer, Department of Oral Medicine and Radiology, Mahatma Gandhi Dental College , Mumbai, India .
authors.forename: Neha
authors.initials: N
authors.lastname: Patil
authors.affiliation: Associate Professor, Department of Periodontology and Implantology, Universal College of Dental Sciences , Bhairahawa, Nepal .
authors.forename: Manoj
authors.initials: M
authors.lastname: Yadav
authors.affiliation: Assistant Professor, Department of Oral Surgery, Universal College of Dental Sciences , Bhairahawa, Nepal .
authors.forename: Shashank
authors.initials: S
authors.lastname: Tripathi
authors.affiliation: Assistant Professor, Department of Periodontology and Implantology, Universal College of Dental Sciences , Bhairahawa, Nepal .
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sinha
authors.affiliation: Senior Lecturer, Department of Orthodontics, Maitri College of Dentistry and Research Centre , Anjora, Durg (Chattisgarh), India .
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Professor, Department of Conservative Dentistry and Endodontics, DAV Dental College , Yamunanagar (Haryana), India .
authors.forename: Saurabh
authors.initials: S
authors.lastname: Gupta
keywords: Inflammatory disease; Periodontal infection