title: Sleep, Fatigue, and Problems With Cognitive Function in Adults Living With HIV.
abstract: Up to 50% of people living with HIV have some neurocognitive impairment. We examined associations of sleep and fatigue with self-reported cognitive problems in 268 adults living with HIV. Multivariate regression was used to examine associations between cognitive problems, self-reported sleep quality, actigraphy-measured total sleep time and wake after sleep onset, and fatigue severity. Poorer self-reported sleep quality (p < .001), short or long total sleep time (<7 or >8 vs. 7-8 hours, p = .015), and greater fatigue (p < .001) were associated with lower self-reported cognitive function scores after controlling for demographic and clinical characteristics. However, objective measure of wake after sleep onset was unrelated to self-reported cognitive function scores. Findings suggest that assessing and treating poor sleep and complaints about fatigue would be areas for intervention that could have a greater impact on improving cognition function than interventions that target only cognitive problems.
authors.forename: Eeeseung
authors.initials: E
authors.lastname: Byun
authors.forename: Caryl L
authors.initials: CL
authors.lastname: Gay
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Lee
mesh_terms: D056044:Actigraphy; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D002140:California / Q000453:epidemiology; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D003430:Cross-Sectional Studies; D005221:Fatigue / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011788:Quality of Life; D012044:Regression Analysis; D057566:Self Report; D012890:Sleep; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D012893:Sleep Wake Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D011795:Surveys and Questionnaires
chemical_list: D044966:Anti-Retroviral Agents
keywords: HIV; cognition; fatigue; sleep