title: Cytotoxic compounds from Laurencia pacifica.
abstract: BACKGROUND
  The current investigation sought to explore the nature of the secondary metabolites in the algae, Laurencia pacifica.
  
  
  RESULTS
  This report details the first isolation of the sesquiterpenes isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), 10α-hydroxyldebromoepiaplysin (6), and the previously unknown 10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol (7) from the algae, Laurencia pacifica. Isoaplysin (1) and debromoaplysinol (4) showed promising levels of growth inhibition against a panel cancer-derived cell lines of colon (HT29), glioblastoma (U87, SJ-G2), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (Du145), neuroblastoma (BE2-C), pancreas (MIA), murine glioblastoma (SMA) origin with average GI50 values of 23 and 14 μM.
  
  
  CONCLUSIONS
  Isoaplysin (1) and debromoaplysinol (4) were up to fourfold more potent in cancer-derived cell populations than in non-tumor-derived normal cells (MCF10A). These analogues are promising candidates for anticancer drug development. Graphical Abstract ᅟ.
authors.affiliation: Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. Diana.Zaletapinet@uon.edu.au.
authors.forename: Diana A
authors.initials: DA
authors.lastname: Zaleta-Pinet
authors.affiliation: Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. Ian.Holland@uon.edu.au.
authors.forename: Ian P
authors.initials: IP
authors.lastname: Holland
authors.affiliation: Development Technology Department, Interdisciplinary Centre of Marine Sciences, National Technological Institute, La Paz, Mexico. mmo6709@gmail.com.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Muñoz-Ochoa
authors.affiliation: Development Technology Department, Interdisciplinary Centre of Marine Sciences, National Technological Institute, La Paz, Mexico. jmurilloa@ipn.mx.
authors.forename: J Ivan
authors.initials: JI
authors.lastname: Murillo-Alvarez
authors.affiliation: Department of Medical Oncology, Calvary Mater Newcastle Hospital, Waratah, NSW, 2298, Australia. Jennette.Sakoff@newcastle.edu.au.
authors.forename: Jennette A
authors.initials: JA
authors.lastname: Sakoff
authors.affiliation: Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. Ian.vanaltena@newcastle.edu.au.
authors.forename: Ian A
authors.initials: IA
authors.lastname: van Altena
authors.affiliation: Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. Adam.McCluskey@newcastle.edu.au.
authors.forename: Adam
authors.initials: A
authors.lastname: McCluskey
keywords: Algae; Anti-cancer; Cytotoxicity; Laurencia pacifica; Sesquiterpenes