title: A randomised controlled trial of peri-operative pregabalin vs. placebo for video-assisted thoracoscopic surgery.
abstract: We allocated 52 participants to oral pregabalin 300 mg and 48 participants to placebo tablets before thoracoscopic surgery and for five postoperative days. The median (IQR [range]) cumulative pain scores at rest for nine postoperative months were 184 (94-274 [51-1454]) after pregabalin and 166 (66-266 [48-1628]) after placebo, p = 0.39. The corresponding scores on deep breathing were 468 (281-655 [87-2870]) and 347 (133-561 [52-3666]), respectively, p = 0.16. After three postoperative months, 29/100 participants had persistent surgical site pain, 19/52 after pregabalin and 10/48 after placebo, p = 0.12, of whom four and five, respectively, attended a pain management clinic, p = 0.24. The median (IQR [range]) morphine equivalent consumption six days after surgery was 273 (128-619 [39-2243]) mg after pregabalin and 319 (190-663 [47-2258]) mg after placebo, p = 0.35.
authors.affiliation: Department of Anaesthesia and Peri-operative Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: A H
authors.initials: AH
authors.lastname: Konstantatos
authors.affiliation: Department of Anaesthesia, Austin Hospital, Melbourne, Victoria, Australia.
authors.forename: W
authors.initials: W
authors.lastname: Howard
authors.affiliation: Anaesthesia, Peri-operative and Pain Medicine Unit, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Story
authors.affiliation: Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.
authors.forename: L Y H
authors.initials: LY
authors.lastname: Mok
authors.affiliation: Department of Anaesthesia and Peri-operative Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Boyd
authors.affiliation: Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.
authors.forename: M T V
authors.initials: MT
authors.lastname: Chan
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010149:Postoperative Pain / Q000188:drug therapy*; D010919:Placebos; D011182:Postoperative Care; D000069583:Pregabalin / Q000627:therapeutic use*; D011300:Preoperative Care; D011788:Quality of Life; D020775:Thoracic Surgery, Video-Assisted
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D010919:Placebos; D000069583:Pregabalin; D009020:Morphine