title: Meta-Analysis of Association of Obstructive Sleep Apnea With Glaucoma.
abstract: OBJECTIVE
  Previous studies suggested that obstructive sleep apnea (OSA) was associated with glaucoma. However, data on this issue are controversial. This study aims to use meta-analysis to determine whether OSA is related to glaucoma.
  
  
  METHODS
  We searched PubMed, Embase, the Cochrane library, the Web of Science, and the Chinese BioMedical Literature Database disk databases up to November 20, 2014 for related literature. The association of OSA with glaucoma was assessed by odds ratio (OR) with 95% confidence interval (CI) as the effect size. Then subgroup analysis was performed according to area and glaucoma type.
  
  
  RESULTS
  Six primary studies (3 cohort study and 3 case-control studies) were included in this meta-analysis involving 2,288,701 participants. There was a significant association between OSA and glaucoma (adjusted-effect summary for case-control studies OR=2.46; 95% CI, 1.32-4.59, P=0.005) (adjusted-effect summary for cohort studies OR=1.43; 95% CI, 1.21-1.69, P=0.000). There was no significant publication bias.
  
  
  CONCLUSIONS
  OSA was a risk factor for glaucoma. A large number of studies is needed to explore the mechanisms that link OSA with glaucoma.
authors.affiliation: *Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, The First Affiliated Hospital of Chongqing Medical University Departments of †Traditional Chinese Medicine ‡Clinical Pharmacy, Chongqing Medical University, Chongqing, China.
authors.forename: Shulin
authors.initials: S
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Lin
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
mesh_terms: D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D005901:Glaucoma / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D016017:Odds Ratio; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology* / Q000503:physiopathology