title: Evolutionary Rate Heterogeneity of Primary and Secondary Metabolic Pathway Genes in Arabidopsis thaliana.
abstract: Primary metabolism is essential to plants for growth and development, and secondary metabolism helps plants to interact with the environment. Many plant metabolites are industrially important. These metabolites are produced by plants through complex metabolic pathways. Lack of knowledge about these pathways is hindering the successful breeding practices for these metabolites. For a better knowledge of the metabolism in plants as a whole, evolutionary rate variation of primary and secondary metabolic pathway genes is a prerequisite. In this study, evolutionary rate variation of primary and secondary metabolic pathway genes has been analyzed in the model plant Arabidopsis thaliana. Primary metabolic pathway genes were found to be more conserved than secondary metabolic pathway genes. Several factors such as gene structure, expression level, tissue specificity, multifunctionality, and domain number are the key factors behind this evolutionary rate variation. This study will help to better understand the evolutionary dynamics of plant metabolism.
authors.affiliation: Bioinformatics Centre, Bose Institute, Kolkata, West Bengal, India.
authors.forename: Dola
authors.initials: D
authors.lastname: Mukherjee
authors.affiliation: Department of Botany, Vivekananda College, Thakurpukur, Kolkata, West Bengal, India ashutoshcaluniv@gmail.com tapash@boseinst.ernet.in.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: Bioinformatics Centre, Bose Institute, Kolkata, West Bengal, India ashutoshcaluniv@gmail.com tapash@boseinst.ernet.in.
authors.forename: Tapash Chandra
authors.initials: TC
authors.lastname: Ghosh
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D003062:Codon / Q000235:genetics; D017124:Conserved Sequence; D019143:Evolution, Molecular; D018740:Genetic Heterogeneity
chemical_list: D029681:Arabidopsis Proteins; D003062:Codon
keywords: effective number of codons; metabolic pathway genes; multifunctionality; principal component analysis