title: Efficacy of Zinc Sulfate as an Add-on Therapy to Risperidone Versus Risperidone Alone in Patients With Schizophrenia: A Double-Blind Randomized Placebo-Controlled Trial.
abstract: BACKGROUND
  Zinc can modulate fast-excitatory transmission, facilitate the release of amino butyric acid and potentiate nicotinic acetylcholine receptors. There are also emerging evidences discussing the implication of these neurotransmitters in pathophysiology of schizophrenia.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the efficacy of Zn sulfate as an add-on therapy in the treatment of schizophrenia in a 6-week, double-blind and placebo-controlled trial.
  
  
  METHODS
  Eligible participants were 30 inpatients with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. Patients were randomly allocated into two equal groups; one group of patients received risperidone 6 mg/day plus capsules of Zn sulfate (each containing 50 mg elemental Zn) three times a day and another group received risperidone 6 mg/day plus placebo. The Positive and Negative Syndrome Scale (PANSS) was applied to assess the psychotic symptoms and aggression risk at baseline, week 2, 4, and 6 of the study.
  
  
  RESULTS
  The results of this study showed that both protocols significantly decreased the scores on all subscales of the PANSS and supplemental aggression risk subscale as well as PANSS total score over the study. However, this improvement was significantly higher in Zn sulfate receiving group compared to the placebo group. No major clinical side-effects were detected.
  
  
  CONCLUSIONS
  It may be concluded that Zn is an effective adjuvant agent in the management of patients with schizophrenia.
authors.affiliation: Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Mortazavi
authors.affiliation: Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, IR Iran ; Department of Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Davood
authors.initials: D
authors.lastname: Farzin
authors.affiliation: Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, IR Iran ; Department of Psychiatry, School of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Zarhghami
authors.affiliation: Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, IR Iran ; Department of Psychiatry, School of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Seyed Hamzeh
authors.initials: SH
authors.lastname: Hosseini
authors.affiliation: Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Mansoori
authors.affiliation: Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, IR Iran ; Department of Psychiatry, School of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Nateghi
keywords: Risperidone; Scale; Schizophrenia; Syndrome; Zinc