title: Gold over Branched Palladium Nanostructures for Photothermal Cancer Therapy.
abstract: Bimetallic nanostructures show exciting potential as materials for effective photothermal hyperthermia therapy. We report the seed-mediated synthesis of palladium-gold (Pd-Au) nanostructures containing multiple gold nanocrystals on highly branched palladium seeds. The nanostructures were synthesized via the addition of a gold precursor to a palladium seed solution in the presence of oleylamine, which acts as both a reducing and a stabilizing agent. The interaction and the electronic coupling between gold nanocrystals and between palladium and gold broadened and red-shifted the localized surface plasmon resonance absorption maximum of the gold nanocrystals into the near-infrared region, to give enhanced suitability for photothermal hyperthermia therapy. Pd-Au heterostructures irradiated with an 808 nm laser light caused destruction of HeLa cancer cells in vitro, as well as complete destruction of tumor xenographs in mouse models in vivo for effective photothermal hyperthermia.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: McGrath
authors.affiliation: Department of Chemistry, Center for Micro/Nano Science and Technology and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Chien
authors.forename: Soshan
authors.initials: S
authors.lastname: Cheong
authors.forename: David A J
authors.initials: DA
authors.lastname: Herman
authors.forename: John
authors.initials: J
authors.lastname: Watt
authors.forename: Anna M
authors.initials: AM
authors.lastname: Henning
authors.forename: Lucy
authors.initials: L
authors.lastname: Gloag
authors.affiliation: Department of Chemistry, Center for Micro/Nano Science and Technology and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Chen-Sheng
authors.initials: CS
authors.lastname: Yeh
authors.forename: Richard D
authors.initials: RD
authors.lastname: Tilley
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008297:Male; D051379:Mice; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000473:pathology; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology; D010789:Phototherapy / Q000379:methods*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D010165:Palladium; D006046:Gold
keywords: gold; hyperthermia; nanoparticles; nanostructures; palladium