title: [Prevalence of Variants in the Apolipoprotein E (APOE) Gene in a General Population of Adults from an Urban Area of Medellin (Antioquia)].
abstract: OBJECTIVE
  To determine the allelic and genotype frequencies of apolipoproteine E (APOE) gene in a representative sample of the adult population of Medellin in 2010.
  
  
  METHODS
  A representative sample of the adult population of Medellin, was obtained by means of a multi-stage, stratified, conglomerate based sampling method. APOE genotyping was carried out on each of the participants. The sampling design was taken into consideration for the frequencies and association analysis.
  
  
  RESULTS
  The frequencies of the APOE alleles E2, E3 and E4 were 3.9, 92.0 and 4.1%, respectively. The frequencies of the different APOE genotypes were as follows: 2/2, 0.2%; 2/3, 6.8%; 2/4, 0.6%; 3/3, 85.0%; 3/4, 7.2%, and 4/4, 0.3%.
  
  
  CONCLUSIONS
  The allelic and genotype frequencies of APOE in an adult population of Medellin did not differ substantially from other series reported in South America. These data are important to determine the real impact of APOE on the population risk of several psychiatric diseases.
authors.affiliation: Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Hospital Universitario San Vicente Fundación, Medellín, Colombia.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Arango Viana
authors.affiliation: Docente Investigadora, Facultad de Medicina, Universidad Pontificia Bolivariana, Medellín, Colombia.
authors.forename: Ana Victoria
authors.initials: AV
authors.lastname: Valencia
authors.affiliation: Laboratorio de Genética Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Ana Lucía
authors.initials: AL
authors.lastname: Páez
authors.affiliation: Gestión de Información y Bases de Datos, Facultad Nacional de Salud Pública, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Nilton
authors.initials: N
authors.lastname: Montoya Gómez
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Carlos
authors.initials: C
authors.lastname: Palacio
authors.affiliation: Departamento de Ciencias Básicas, Facultad Nacional de Salud Pública, Universidad de Antioquia, Medellín, Colombia.
authors.forename: María Patricia
authors.initials: MP
authors.lastname: Arbeláez
authors.affiliation: Laboratorio de Genética Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bedoya Berrío
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Electronic address: jegava@gmail.com.
authors.forename: Jenny
authors.initials: J
authors.lastname: García Valencia
keywords: Alzheimer disease; Apolipoprotein E; Apolipoproteína E; Enfermedad de Alzheimer; Esquizofrenia; Genetics; Genética; Prevalence; Prevalencia; Schizophrenia