title: Influence of AIDS in collagen deposition and thickness of the bone marrow.
abstract: Bone marrow abnormalities are frequently observed in individuals with AIDS. Dysplasia, the most common abnormality, is found in more than 50% of patients infected with the HIV. The aim of this study was to assess trabecular thickness and collagen content as well as cellularity in the bone marrow of patients with AIDS. Sixty bone marrow samples were collected from the sternum of autopsied patients with or without AIDS (n = 30, each). Cellularity and trabecular thickness was assessed by performing hematoxylin-eosin staining; picrosirius staining was used to evaluate collagen content. Morphometric analyses were performed by using a Zeiss KS300 system (Kontron-Zeiss). Patients with AIDS showed a significant reduction in trabecular bone thickness and an increase in collagen deposition. No statistically significant differences were observed in cellularity between the 2 groups. Therefore, reduced thickness and increased collagen deposition were observed in the trabeculae of the bone marrow of patients with AIDS due to possible interaction between cytokines and bone marrow components.
authors.affiliation: General Pathology Division, Biological and Natural Science Institute, Triângulo Mineiro Federal University (UFTM), Uberaba, Minas Gerais, Brazil.
authors.forename: Natália Ferreira Ribeiro
authors.initials: NF
authors.lastname: Dias
authors.affiliation: General Pathology Division, Biological and Natural Science Institute, Triângulo Mineiro Federal University (UFTM), Uberaba, Minas Gerais, Brazil.
authors.forename: Guilherme Ribeiro
authors.initials: GR
authors.lastname: Juliano
authors.affiliation: General Pathology Division, Biological and Natural Science Institute, Triângulo Mineiro Federal University (UFTM), Uberaba, Minas Gerais, Brazil. Electronic address: anapaulaespindula@yahoo.com.br.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Espindula
authors.affiliation: General Pathology Sector, Tropical Pathology and Health Public Institute (IPTSP), Goiás Federal University (UFG), Goiânia - GO, Brazil.
authors.forename: Flávia Aparecida
authors.initials: FA
authors.lastname: de Oliveira
authors.affiliation: General Pathology Division, Biological and Natural Science Institute, Triângulo Mineiro Federal University (UFTM), Uberaba, Minas Gerais, Brazil.
authors.forename: Lívia Ferreira
authors.initials: LF
authors.lastname: Oliveira
authors.affiliation: General Pathology Division, Biological and Natural Science Institute, Triângulo Mineiro Federal University (UFTM), Uberaba, Minas Gerais, Brazil.
authors.forename: Camila Lourencini
authors.initials: CL
authors.lastname: Cavellani
authors.affiliation: General Pathology Division, Biological and Natural Science Institute, Triângulo Mineiro Federal University (UFTM), Uberaba, Minas Gerais, Brazil.
authors.forename: Luciana Santos
authors.initials: LS
authors.lastname: Ramalho
authors.affiliation: General Pathology Division, Biological and Natural Science Institute, Triângulo Mineiro Federal University (UFTM), Uberaba, Minas Gerais, Brazil.
authors.forename: Vicente de Paula Antunes
authors.initials: Vde P
authors.lastname: Teixeira
authors.affiliation: General Pathology Division, Biological and Natural Science Institute, Triângulo Mineiro Federal University (UFTM), Uberaba, Minas Gerais, Brazil.
authors.forename: Mara Lúcia da Fonseca
authors.initials: ML
authors.lastname: Ferraz
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D001854:Bone Marrow Cells / Q000378:metabolism* / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D003094:Collagen
keywords: AIDS; Bone marrow; Collagen