title: Synaptic interactions and inhibitory regulation in auditory cortex.
abstract: This Special Issue focuses on the auditory-evoked mismatch negativity (MMN), an electrophysiological index of change, and its reduction in schizophrenia. The following brief review is an attempt to complement the behavioral and clinical contributions to the Special Issue by providing basic information on synaptic interactions and processing in auditory cortex. A key observation in previous studies is that the MMN involves activation of cortical N-methyl-D-aspartate (NMDA) receptors. Yet, NMDA receptor activation is regulated by a number of synaptic events, which also may contribute to the MMN reduction in schizophrenia. Accordingly, this review will focus on synaptic interactions, notably inhibitory regulation of NMDA receptor-mediated activity, in auditory cortex.
authors.affiliation: Department of Neurobiology and Behavior, Center for Hearing Research, University of California, Irvine, CA 92697, USA.
authors.forename: Caitlin E
authors.initials: CE
authors.lastname: Askew
authors.affiliation: Department of Neurobiology and Behavior, Center for Hearing Research, University of California, Irvine, CA 92697, USA. Electronic address: raju.metherate@uci.edu.
authors.forename: Raju
authors.initials: R
authors.lastname: Metherate
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D054351:Electrical Synapses / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D018682:GABA Agents / Q000378:metabolism; D006801:Humans; D007395:Interneurons / Q000502:physiology; D051379:Mice; D051381:Rats; D018080:Receptors, GABA-B / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012559:Schizophrenia / Q000503:physiopathology
chemical_list: D018682:GABA Agents; D018080:Receptors, GABA-B; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Auditory cortex; GABA; Glutamate; Mismatch negativity; NMDA; Neuromodulation; Nicotinic acetylcholine receptor; Synaptic integration; Thalamocortical