title: Chemotherapy-induced peripheral neuropathy: Current status and progress.
abstract: As there are increasing numbers of cancer survivors, more attention is being paid to the long term unwanted effects patients may experience as a result of their treatment and the impact these side effects can have on their quality of life. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common long-term toxicities from chemotherapy. In this review we will briefly review the clinical presentation, evaluation and management of chemotherapy-induced peripheral neuropathy, with a focus on CIPN related to platinum and taxane agents. We will then discuss current clinical models of peripheral neuropathy and ongoing research to better understand CIPN and develop potential treatment options.
authors.affiliation: Section of Hematology-Oncology, Department of Medicine, University of Chicago Medical Center, 5841 S. Maryland Ave, Chicago, IL 60637, United States.
authors.forename: Jamie R
authors.initials: JR
authors.lastname: Brewer
authors.affiliation: Section of Hematology-Oncology, Department of Medicine, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, IL 60637, United States.
authors.forename: Gladys
authors.initials: G
authors.lastname: Morrison
authors.affiliation: Section of Hematology-Oncology, Department of Medicine, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, IL 60637, United States.
authors.forename: M Eileen
authors.initials: ME
authors.lastname: Dolan
authors.affiliation: Section of Hematology-Oncology, Department of Medicine, The University of Chicago, Knapp Center for Biomedical Discovery, 900 East 57th Street, Chicago, IL 60637, United States. Electronic address: gfleming@medicine.bsd.uchicago.edu.
authors.forename: Gini F
authors.initials: GF
authors.lastname: Fleming
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D000077143:Docetaxel; D006801:Humans; D008959:Models, Neurological; D058953:Neural Stem Cells / Q000473:pathology; D009474:Neurons / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel
keywords: Chemotherapy; Neuropathy; Toxicity