title: Organometallic rhodium(III) and iridium(III) cyclopentadienyl complexes with curcumin and bisdemethoxycurcumin co-ligands.
abstract: A series of half-sandwich cyclopentadienyl rhodium(III) and iridium(III) complexes of the type [Cp*M(curc/bdcurc)Cl] and [Cp*M(curc/bdcurc)(PTA)][SO3CF3], in which Cp* = pentamethylcyclopentadienyl, curcH = curcumin and bdcurcH = bisdemethoxycurcumin as O^O-chelating ligands, and PTA = 1,3,5-triaza-7-phosphaadamantane, is described. The X-ray crystal structures of three of the complexes, i.e. [Cp*Rh(curc)(PTA)][SO3CF3] (5), [Cp*Rh(bdcurc)(PTA)][SO3CF3] (6) and [Cp*Ir(bdcurc)(PTA)][SO3CF3] (8), confirm the expected "piano-stool" geometry. With the exception of 5, the complexes are stable under pseudo-physiological conditions and are moderately cytotoxic to human ovarian carcinoma (A2780 and A2780cisR) cells and also to non-tumorigenic human embryonic kidney (HEK293) cells, but lack the cancer cell selectivity observed for related arene ruthenium(II) complexes.
authors.affiliation: School of Pharmacy, University of Camerino, via S. Agostino 1, 62032 Camerino MC, Italy. riccardo.pettinari@unicam.it.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pettinari
authors.forename: Fabio
authors.initials: F
authors.lastname: Marchetti
authors.forename: Claudio
authors.initials: C
authors.lastname: Pettinari
authors.forename: Francesca
authors.initials: F
authors.lastname: Condello
authors.forename: Agnese
authors.initials: A
authors.lastname: Petrini
authors.forename: Rosario
authors.initials: R
authors.lastname: Scopelliti
authors.forename: Tina
authors.initials: T
authors.lastname: Riedel
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D036381:Diarylheptanoids; D057809:HEK293 Cells; D006801:Humans; D007495:Iridium / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D012238:Rhodium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D036381:Diarylheptanoids; D008024:Ligands; C034786:bisdemethoxycurcumin; D007495:Iridium; D012238:Rhodium; D003474:Curcumin