title: Synthesis of New 'Hybrid' Compounds Based on Benzofuroxans and Aminoalkylnaphthalimides.
abstract: Pathogenic bacteria and fungi eventually develop resistance to existing drugs, and therefore, we need constant development of new drugs. The research is aimed at addressing fundamental scientific problems-the search for new biologically active compounds among several benzofuroxan-containing 'hybrid' products. N-substituted naphthalimides were chosen as a second pharmacophore. Benzofuroxanes biological effects were studied by means of bacterial lux-biosensors. Compounds IIIa, IVa, IIIc, and IVc displayed more expressed bacteriotoxic action in comparison with the initial substances Ia-c and represent a certain interest for using as antibacterial substances.
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov st. 8, Kazan, 420088, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Chugunova
authors.affiliation: Kazan National Research Technological University, 68 Karl Marx st., Kazan, 420015, Russia.
authors.forename: Rezeda
authors.initials: R
authors.lastname: Mukhamatdinova
authors.affiliation: Southern Federal University (SFedU), 194/1 Stachki ave., Rostov-on-Don, 344090, Russia.
authors.forename: Marina
authors.initials: M
authors.lastname: Sazykina
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov st. 8, Kazan, 420088, Russia.
authors.forename: Alexey
authors.initials: A
authors.lastname: Dobrynin
authors.affiliation: Southern Federal University (SFedU), 194/1 Stachki ave., Rostov-on-Don, 344090, Russia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Sazykin
authors.affiliation: A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine, 68 Lustdofska driveway, Odessa, 65080, Ukraine.
authors.forename: Alexander
authors.initials: A
authors.lastname: Karpenko
authors.affiliation: Southern Federal University (SFedU), 194/1 Stachki ave., Rostov-on-Don, 344090, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Mirina
authors.affiliation: Southern Federal University (SFedU), 194/1 Stachki ave., Rostov-on-Don, 344090, Russia.
authors.forename: Maria
authors.initials: M
authors.lastname: Zhuravleva
authors.affiliation: Kazan National Research Technological University, 68 Karl Marx st., Kazan, 420015, Russia.
authors.forename: Nikolai
authors.initials: N
authors.lastname: Gavrilov
authors.affiliation: Southern Federal University (SFedU), 194/1 Stachki ave., Rostov-on-Don, 344090, Russia.
authors.forename: Shorena
authors.initials: S
authors.lastname: Karchava
authors.affiliation: A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov st. 8, Kazan, 420088, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Burilov
mesh_terms: D001583:Benzoxazoles / Q000737:chemistry*; D018360:Crystallography, X-Ray; D053644:Naphthalimides / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D010069:Oxadiazoles
chemical_list: D001583:Benzoxazoles; D053644:Naphthalimides; C014354:benzofuroxan; D010069:Oxadiazoles
keywords: aminoalkylnaphthalimide; bacterial lux-biosensor; benzofuroxan; ‘hybrid’ compound