title: Association of HLA-DRB1 Alleles with Ulcerative Colitis in the City of Kerman, South Eastern Iran.
abstract: The association of HLA class II genes with ulcerative colitis (UC) as an autoimmune disease has been investigated for several years. However, factors responsible for genetic predisposition of this disease have so far not been clearly understood. In this study, for the first time, we aimed to investigate the association between HLA-DRB1 types and UC in the population of Kerman, a city southeast Iran. HLA typing was performed among 85 UC patients and 95 healthy controls using PCR amplification, employing sequence specific primers (PCR-SSP). The DRB1 frequencies were determined in the patients and controls. HLA-DRB1*04 was negatively associated with UC. Furthermore, HLA-DRB1*13 was significantly associated with severity of the disease (p=0.01) among UC patients. This is the novel result that describes an association of HLA-DRB1*13 with UC and also shows the protective role of HLA-DRB1*04 against the disease in people of Kerman.
authors.affiliation: Physiology Research Center, Institute of Neuropharmacology, Kerman Universityof Medical Sciences, Kerman, Iran, AND Department of Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Mohammadi
authors.affiliation: Department of Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Rastin
authors.affiliation: Inflammation and Inflammatory Diseases Research Center,School of Medicine, Mashhad University of Medical sciences,Mashhad, Iran.
authors.forename: Houshang
authors.initials: H
authors.lastname: Rafatpanah
authors.affiliation: Physiology Research Center, Institute of Neuropharmacology, Kerman Universityof Medical Sciences, Kerman, Iran.
authors.forename: Haleh
authors.initials: H
authors.lastname: Abdoli Sereshki
authors.affiliation: Department of Gastroenterology, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Zahedi
authors.affiliation: Department of Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amin Reza
authors.initials: AR
authors.lastname: Nikpoor
authors.affiliation: Modelling in Health Research Centre, Institute of Future Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Baneshi
authors.affiliation: Department of Gastroenterology, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran AND Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology sciences,, Kerman University of medical Sciences, Kerman, Iran.
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Hayatbakhsh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003093:Colitis, Ulcerative / Q000235:genetics*; D005260:Female; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D059811:HLA-DRB1 Chains; C527195:HLA-DRB1*04 antigen; C506473:HLA-DRB1*13 antigen
keywords: HLA-DRB1; IBD; Iran; PCR-SSP; Ulcerative colitis