title: Potential impact of the human papillomavirus vaccine on the incidence proportion of genital warts in French women (EFFICAE study): a multicentric prospective observational study.
abstract: Background The objective was to evaluate the effect of a HPV vaccination program on the incidence proportion of a proxy, genital warts (GW), in women in France.
  
  
  
  The number of primary GW cases was prospectively recorded over two 4-month periods before (T0: Dec 2008 to March 2009) and after (T1: Dec 2011 to March 2012) a HPV vaccination program. A total of 160 gynaecologists participated in T0 and 189 in T1. Primary genital herpes (HSV) infection was used as a control.
  
  
  
  During T0, 39190 15- to 26 year-old women were seen, of whom 176 were diagnosed with GW (incidence proportion: 0.45%) and 155 with primary HSV infection (incidence proportion: 0.39%). During T1, 45628 females were seen [229 with GW (incidence proportion: 0.50%) and 202 with HSV (incidence proportion: 0.44%)]. In the 15-20 years age category, the incidence proportion of primary GW decreased from 0.41% to 0.30% (P=0.128) between T0 and T1, and the proportion of women newly diagnosed with primary genital herpes diseases slightly increased from 0.34% to 0.38% (P=0.620). In the 15-18 years age group, this decrease became significant (0.34% to 0.18%; P=0.048).
  
  
  
  A trend for a non-significant decreased incidence proportion of GW was observed in young women below 20 years who are more frequently vaccinated. This may be the result of HPV vaccination and suggests that a substantial increase in vaccine coverage could lead to a more pronounced decreased incidence proportion of GW in the future.
authors.affiliation: Pôle de Gynécologie, Obstétrique et Reproduction, Maternité régionale universitaire de Nancy, 10, rue du Dr Heydenreich -CS 74213-54 042 Nancy Cedex, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Judlin
authors.affiliation: Sanofi Pasteur MSD, 8, rue Jonas Salk, 69367 Lyon Cedex 07, France.
authors.forename: Anne-Carole
authors.initials: AC
authors.lastname: Jacquard
authors.affiliation: Department of Obstetrics and Gynaecology, Assistance Publique des Hôpitaux de Marseille (APHM), Hôpital Nord, Chemin des Bourrely, 13915 Marseille cedex 20, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Carcopino
authors.affiliation: EA3181, SFR FED 4234, Université de Franche-Comté, Bâtiment INSERM, 20 rue Françoise Dolto, 25000 Besançon, France.
authors.forename: François
authors.initials: F
authors.lastname: Aubin
authors.affiliation: Sanofi Pasteur MSD, 8, rue Jonas Salk, 69367 Lyon Cedex 07, France.
authors.forename: André
authors.initials: A
authors.lastname: Dahlab
authors.affiliation: RCTS, 38 Rue du Plat, 69002 Lyon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Mistretta
authors.affiliation: RCTS, 38 Rue du Plat, 69002 Lyon, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Not
authors.affiliation: Faculté de Médecine Pierre et Marie Curie, INSERM UMR S707, APHP, 27, rue de Chaligny, 75571 Paris, Cedex 12, France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Boelle
authors.affiliation: Dermatology Department, University Hospital Cochin, 89, rue d'Assas, 75006 Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Aynaud
authors.affiliation: Sanofi Pasteur MSD, 8, rue Jonas Salk, 69367 Lyon Cedex 07, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Soubeyrand
mesh_terms: D000293:Adolescent; D000328:Adult; D003218:Condylomata Acuminata / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000517:prevention & control; D053918:Papillomavirus Vaccines / Q000627:therapeutic use*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D053918:Papillomavirus Vaccines