title: Preparation of N-Substituted N-Arylsulfonylglycines and Their Use in Peptoid Synthesis.
abstract: To increase the chemical diversity accessible with peptoids and peptide-peptoid hybrids, N-alkylated arylsulfonamides were used to prepare side chain protected N-substituted glycines compatible with solid-phase synthesis. The described procedures give access to peptoid monomers bearing a wide variety of functional groups from commercially available amines in four straightforward steps. The prepared N-substituted N-arylsulfonylglycines were used as monomers in solid-phase synthesis to introduce relevant functionalized side chains into peptoid oligomers and peptide-peptoid hybrids.
authors.affiliation: Faculty of Pharmacy, Université Laval , Québec, Québec G1V 0A6, Canada.|Laboratory of Medicinal Chemistry, Centre de Recherche du Centre Hospitalier Universitaire de Québec , 2705 Boulevard Laurier, Québec, Québec G1V 4G2, Canada.
authors.forename: Steve
authors.initials: S
authors.lastname: Jobin
authors.affiliation: Faculty of Pharmacy, Université Laval , Québec, Québec G1V 0A6, Canada.|Laboratory of Medicinal Chemistry, Centre de Recherche du Centre Hospitalier Universitaire de Québec , 2705 Boulevard Laurier, Québec, Québec G1V 4G2, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Vézina-Dawod
authors.affiliation: Faculty of Pharmacy, Université Laval , Québec, Québec G1V 0A6, Canada.|Laboratory of Medicinal Chemistry, Centre de Recherche du Centre Hospitalier Universitaire de Québec , 2705 Boulevard Laurier, Québec, Québec G1V 4G2, Canada.
authors.forename: Claire
authors.initials: C
authors.lastname: Herby
authors.affiliation: Faculty of Pharmacy, Université Laval , Québec, Québec G1V 0A6, Canada.|Laboratory of Medicinal Chemistry, Centre de Recherche du Centre Hospitalier Universitaire de Québec , 2705 Boulevard Laurier, Québec, Québec G1V 4G2, Canada.
authors.forename: Antoine
authors.initials: A
authors.lastname: Derson
authors.affiliation: Faculty of Pharmacy, Université Laval , Québec, Québec G1V 0A6, Canada.|Laboratory of Medicinal Chemistry, Centre de Recherche du Centre Hospitalier Universitaire de Québec , 2705 Boulevard Laurier, Québec, Québec G1V 4G2, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Biron
mesh_terms: D000588:Amines / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques
chemical_list: D000588:Amines; D010455:Peptides; D034444:Peptoids; D005998:Glycine