title: Association between various anthropometric measures of obesity and markers of subclinical atherosclerosis.
abstract: Central obesity is a known cardiovascular risk factor and measures of visceral obesity are known to predict atherosclerosis. This study sought to explore the association between various anthropometric measures and markers of subclinical atherosclerosis (MoSCA) among low risk healthy individuals. Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of Caucasian (38%), Afro-American (28%), Chinese (22%) and Hispanic (12%) subjects, aged 45-84 years, free from clinical cardiovascular disease. We performed a post hoc analysis of the limited access dataset of MESA subjects to evaluate the association between carotid intima media thickness and coronary artery calcium score (CACS), as MoSCA and various measures of obesity. Multivariable regression analyses adjusted for traditional cardiovascular risk factors, ethnicity and C-reactive protein were performed. Each unit increase in waist-hip ratio was strongly associated with increase in both common and internal carotid intima media thickness (beta: 0.12, 95% confidence interval (CI): 0.06 to 0.18, p < 0.001 and beta: 0.23, 95% CI: 0.03 to 0.43, p = 0.021, respectively). Measures of central obesity were superior to body mass index as demonstrated by their consistent association with each category of CACS when compared to the reference category (CACS = 0). Compared to body mass index, measures of visceral obesity were significantly associated with MoSCA in this multiethnic healthy population. Waist-hip ratio seems to be more consistent in its association with various MoSCA compared to other anthropometric measures.
authors.affiliation: a Division of Cardiology, Department of Internal Medicine , William Beaumont Hospital , Royal Oak , MI , USA.
authors.forename: Naga V A
authors.initials: NV
authors.lastname: Kommuri
authors.affiliation: b Division of Cardiology, Department of Internal Medicine, Detroit Medical Center , Wayne State University , Detroit , MI , USA.
authors.forename: Sandip K
authors.initials: SK
authors.lastname: Zalawadiya
authors.affiliation: b Division of Cardiology, Department of Internal Medicine, Detroit Medical Center , Wayne State University , Detroit , MI , USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Veeranna
authors.affiliation: c Department of Internal Medicine, Detroit Medical Center , Wayne State University , Detroit , MI , USA.
authors.forename: Sri Lakshmi S
authors.initials: SL
authors.lastname: Kollepara
authors.affiliation: c Department of Internal Medicine, Detroit Medical Center , Wayne State University , Detroit , MI , USA.
authors.forename: Krithi
authors.initials: K
authors.lastname: Ramesh
authors.affiliation: b Division of Cardiology, Department of Internal Medicine, Detroit Medical Center , Wayne State University , Detroit , MI , USA.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Briasoulis
authors.affiliation: b Division of Cardiology, Department of Internal Medicine, Detroit Medical Center , Wayne State University , Detroit , MI , USA.
authors.forename: Luis
authors.initials: L
authors.lastname: Afonso
mesh_terms: D000368:Aged; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology; D059168:Carotid Intima-Media Thickness; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D013223:Statistics as Topic; D014481:United States / Q000453:epidemiology; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Anthropometric measures; obesity; subclinical atherosclerosis