title: [Risk factors of obstructive sleep apnea hypopnea syndrome and sleep hypopnea in patients with growth hormone-secreting pituitary adenoma].
abstract: OBJECTIVE
  To investigate the risk factors contributing to the development of obstructive sleep apnea hypopnea syndrome (OSAHS) and sleep hypopnea (SH) in patients with growth hormone-secreting pituitary adenoma (GHPA).
  
  
  METHODS
  A total of 85 patients with GHPA recruited strictly according to the inclusion and exclusion criteria underwent sleep monitoring overnight. Clinical manifestations, laboratory data and magnet resonance images were collected for analysis of the risk factors of GHPA and SH using binary logistic regression analysis.
  
  
  RESULTS
  The prevalence rate of OSAHS was 62.4% (53/85), and that of SH was 75.3% (64/85) in the recruited patients with GHPA. Regression analysis showed that age (OR=1.107) and BMI (OR=1.166) were the risk factors for OSAHS, and BMI (OR=1.334) was the risk factor of SH.
  
  
  CONCLUSIONS
  Ageing and an increased BMI are independent risk factors for OSAHS and SH in patients with GHPA. Preoperative sleep monitoring should be routinely conducted to ensure early diagnosis of OSAHS and SH, and patients with GHPA should be advised to control their body weight to lower the mortality associated with the respiratory system.
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. E-mail: 17701220936@163.com.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: Guo
authors.forename: Lu
authors.initials: L
authors.lastname: Gao
authors.forename: Yi-Lin
authors.initials: YL
authors.lastname: Li
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Yao
authors.forename: Wei
authors.initials: W
authors.lastname: Lian
authors.forename: Ren-Zhi
authors.initials: RZ
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Xing
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000150:complications*; D006801:Humans; D017286:Polysomnography; D015995:Prevalence; D012307:Risk Factors; D012890:Sleep; D012891:Sleep Apnea Syndromes; D020181:Sleep Apnea, Obstructive