title: Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors.
abstract: Thymic epithelial cells give rise to both thymoma and thymic carcinoma. A crucial advance in thymic epithelial tumors (TET) management may derive from the identification of novel molecular biomarkers able to improve diagnosis, prognosis and treatment planning.In a previous study, we identified microRNAs that were differentially expressed in tumor vs normal thymic tissues. Among the microRNAs resulted up-regulated in TET tissues, we evaluated miR-21-5p, miR-148a-3p, miR-141-3p, miR-34b-5p, miR-34c-5p, miR-455-5p as blood plasma circulating non-invasive biomarkers for TET management.We firstly report that the expression levels of specific onco-miRNAs, that we found upregulated in the blood plasma collected from TET patients at surgery, resulted significantly reduced in follow-up samples.This pilot study suggests that circulating miR-21-5p and miR-148a-3p could represent novel non-invasive biomarkers to evaluate the efficacy of therapy and the prognosis of TET.
authors.affiliation: a Department of Anatomical, Histological , Forensic and orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome , Rome , Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Bellissimo
authors.affiliation: b Department of Thoracic Surgery , Azienda Policlinico Umberto I, Sapienza University of Rome, Rome, Italy and Fondazione Eleonora Lorillard Spencer Cenci.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Russo
authors.affiliation: c Translational Oncogenomics Unit, "Regina Elena" National Cancer Institute , Rome , Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Ganci
authors.affiliation: a Department of Anatomical, Histological , Forensic and orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome , Rome , Italy.
authors.forename: Carmen
authors.initials: C
authors.lastname: Vico
authors.affiliation: c Translational Oncogenomics Unit, "Regina Elena" National Cancer Institute , Rome , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sacconi
authors.affiliation: d Department of Radiological , Oncological and Anatomopathological Sciences - Oncology, Sapienza University of Rome , Rome , Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Longo
authors.affiliation: e Department of Radiological , Oncological and Anatomopathological Sciences - Pathology, Sapienza University of Rome , Rome , Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Vitolo
authors.affiliation: b Department of Thoracic Surgery , Azienda Policlinico Umberto I, Sapienza University of Rome, Rome, Italy and Fondazione Eleonora Lorillard Spencer Cenci.
authors.forename: Marco
authors.initials: M
authors.lastname: Anile
authors.affiliation: b Department of Thoracic Surgery , Azienda Policlinico Umberto I, Sapienza University of Rome, Rome, Italy and Fondazione Eleonora Lorillard Spencer Cenci.
authors.forename: Daniele
authors.initials: D
authors.lastname: Disio
authors.affiliation: f Department of Pathology , "Regina Elena" National Cancer Institute , Rome , Italy.
authors.forename: Mirella
authors.initials: M
authors.lastname: Marino
authors.affiliation: c Translational Oncogenomics Unit, "Regina Elena" National Cancer Institute , Rome , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Blandino
authors.affiliation: b Department of Thoracic Surgery , Azienda Policlinico Umberto I, Sapienza University of Rome, Rome, Italy and Fondazione Eleonora Lorillard Spencer Cenci.
authors.forename: Federico
authors.initials: F
authors.lastname: Venuta
authors.affiliation: a Department of Anatomical, Histological , Forensic and orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome , Rome , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fazi
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D013945:Thymoma / Q000097:blood / Q000235:genetics* / Q000473:pathology; D013953:Thymus Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C550570:MIRN148 microRNA, human; C524940:MIRN21 microRNA, human; D035683:MicroRNAs
keywords: Biomarkers; circulating microRNAs; miR-148a-3p; miR-21-5p; microRNAs; thymic epithelial tumors; thymoma