title: Angiotensin receptor blockers (ARBs) reduce the risk of lung cancer: a systematic review and meta-analysis.
abstract: Angiotensin receptor blockers (ARBs) are the most commonly used blood pressure-lowering drugs in the world. However, the preventive value of ARBs on lung cancer is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the value of ARBs on lung cancer risk. We searched the PubMed database as well as the Web of Science database. The overall effect was measured by odds ratio (OR) and corresponding 95% confidence intervals (CI). The significance of the pooled ORs was determined by the Z test with a P value less than 0.05 considering statistically significant. In this meta-analysis, we found ARBs could decrease the lung cancer risk (OR=0.81, 95% CI 0.69-0.54). The stability of the results was tested by sensitivity analysis. The result was not a significant change, suggesting that the result of our meta-analysis was stable. In conclusion, our meta-analysis demonstrated that ARBs was significantly associated with lower lung cancer.
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University No. 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Infectious Disease, The Third Affiliated Hospital of Sun Yat-Sen University No. 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathology, The Third Affiliated Hospital of Sun Yat-Sen University No. 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Jianning
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University No. 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University No. 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University No. 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Huiguo
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University No. 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Weibin
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University No. 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University No. 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Lijia
authors.initials: L
authors.lastname: Gu
keywords: Angiotensin receptor blocker; lung cancer; prevent