title: Early-onset spastic paraparesis as presenting sign of familial Creutzfeldt-Jakob disease.
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples 80138, Italy. Electronic address: francesca.conte@hotmail.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Conte
authors.affiliation: MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy. Electronic address: alfonso.giordano@unina2.it.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Giordano
authors.affiliation: Neuroradiology Service, Second University of Naples, Naples, Italy. Electronic address: fabiotort@libero.it.
authors.forename: Fabio
authors.initials: F
authors.lastname: Tortora
authors.affiliation: MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy. Electronic address: giusysimona@hotmail.com.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Caiazzo
authors.affiliation: Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy. Electronic address: anna.ladogana@iss.it.
authors.forename: Anna
authors.initials: A
authors.lastname: Ladogana
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples 80138, Italy. Electronic address: gioacchino.tedeschi@unina2.it.
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Tedeschi
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples 80138, Italy. Electronic address: alessandro.tessitore@unina2.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Tessitore
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D056324:Diffusion Tensor Imaging; D018450:Disease Progression; D005260:Female; D006801:Humans; D020125:Mutation, Missense; D020336:Paraparesis, Spastic / Q000209:etiology*; D017354:Point Mutation; D000072002:Prion Proteins; D011328:Prions / Q000235:genetics; D013064:Speech Disorders / Q000209:etiology
chemical_list: C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions
keywords: Creutzfeldt–Jakob disease; DTI; PRNP; Spastic paraparesis