title: The Effects That Cardiac Motion has on Coronary Hemodynamics and Catheter Trackability Forces for the Treatment of Coronary Artery Disease: An In Vitro Assessment.
abstract: The coronary arterial tree experiences large displacements due to the contraction and expansion of the cardiac muscle and may influence coronary haemodynamics and stent placement. The accurate measurement of catheter trackability forces within physiological relevant test systems is required for optimum catheter design. The effects of cardiac motion on coronary flowrates, pressure drops, and stent delivery has not been previously experimentally assessed. A cardiac simulator was designed and manufactured which replicates physiological coronary flowrates and cardiac motion within a patient-specific geometry. A motorized delivery system delivered a commercially available coronary stent system and monitored the trackability forces along three phantom patient-specific thin walled compliant coronary vessels supported by a dynamic cardiac phantom model. Pressure drop variation is more sensitive to cardiac motion than outlet flowrates. Maximum pressure drops varied from 7 to 49 mmHg for a stenosis % area reduction of 56 to 90%. There was a strong positive linear correlation of cumulative trackability force with the cumulative curvature. The maximum trackability forces and curvature ranged from 0.24 to 0.87 N and 0.06 to 0.22 mm(-1) respectively for all three vessels. There were maximum and average percentage differences in trackability forces of (23-49%) and (1.9-5.2%) respectively when comparing a static pressure case with the inclusion of pulsatile flow and cardiac motion. Cardiac motion with pulsatile flow significantly altered (p value <0.001) the trackability forces along the delivery pathways with high local percentage variations and pressure drop measurements.
authors.affiliation: Galway Medical Technologies Centre, Department of Mechanical and Industrial Engineering, Galway Mayo Institute of Technology, Galway, Ireland. liam.morris@gmit.ie.
authors.forename: Liam
authors.initials: L
authors.lastname: Morris
authors.affiliation: Galway Medical Technologies Centre, Department of Mechanical and Industrial Engineering, Galway Mayo Institute of Technology, Galway, Ireland.
authors.forename: Paul
authors.initials: P
authors.lastname: Fahy
authors.affiliation: Galway Medical Technologies Centre, Department of Mechanical and Industrial Engineering, Galway Mayo Institute of Technology, Galway, Ireland.
authors.forename: Florian
authors.initials: F
authors.lastname: Stefanov
authors.affiliation: Galway Medical Technologies Centre, Department of Mechanical and Industrial Engineering, Galway Mayo Institute of Technology, Galway, Ireland.
authors.forename: Ronan
authors.initials: R
authors.lastname: Finn
mesh_terms: D000465:Algorithms; D001794:Blood Pressure / Q000502:physiology; D006328:Cardiac Catheterization / Q000379:methods*; D003324:Coronary Artery Disease / Q000503:physiopathology* / Q000628:therapy*; D003331:Coronary Vessels / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000503:physiopathology; D004867:Equipment Design; D006321:Heart / Q000033:anatomy & histology / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology; D011859:Radiography; D015607:Stents
keywords: Cardiac motion; Coronary artery disease; Curvature; Endovascular stents; Pressure drop; Trackability