title: Cardiometabolic Risk Related to the Association of hypertriglyceridemia-Low HDLc.
abstract: OBJECTIVE
  High levels of plasma triglycerides (TG) are a risk factor for cardiovascular diseases often associated with anomalies in other lipids or lipoproteins. However, results from randomized trials, suggesting that low high density lipoprotein cholesterol (HDLc) might not cause cardiovascular disease, as originally thought, have generated renewed interest in increased concentrations of TG. The objective has been to determine the prevalence and factors associated with hypertrigliceridemia (HTG) and with low HDLc.
  
  
  METHODS
  Patients, included in the HTG Registry of the Spanish Association of Atherosclerosis, have been analyzed and anthropometric as well as metabolic data have been collected from them.
  
  
  RESULTS
  1349 patients have been evaluated. Low HDLc has been found in 60.86% (821). Factors significantly associated with low HDLc and HTG were the female sex, being overweight with an increase in the body mass index, using tobacco, diabetes mellitus, low-alcohol consumption and a low exercise rate. Among them, two types of association may be identified with anthropometric variables (especially in men) and metabolic variables (diabetes mellitus and metabolic syndrome). No significant differences have been found insofar as the prevalence of cardiovascular illness between both groups.
  
  
  CONCLUSIONS
  HTG - low HDLc association is very frequent and it is related to overweight-obesity and other metabolic disorders such as diabetes mellitus with or without metabolic syndrome. In addition, these findings underscore the intricate relationship between HDLc, TG, and glucose metabolism that need to be studied simultaneously. In this context, TG lowering treatment is suggested to be more strongly recommended to address the residual risk of atherosclerotic cardiovascular disease.
authors.affiliation: Unit of Vascular Risk and Lipids, Department of Internal Medicine, General University Hospital Gregorio Marañon, School of Medicine of the Complutense University, 46 Dr Esquerdo, 28007 Madrid (Spain). jesus.millan@salud.madrid.org.
authors.forename: Jesús
authors.initials: J
authors.lastname: Millán-Núñez
authors.forename: Teresa
authors.initials: T
authors.lastname: Mantilla-Morató
authors.forename: Rocio
authors.initials: R
authors.lastname: Toro
authors.forename: Joaquin J
authors.initials: JJ
authors.lastname: Millán-Pérez
authors.forename: Alipio
authors.initials: A
authors.lastname: Mangas-Rojas
mesh_terms: D008076:Cholesterol, HDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000453:epidemiology / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000378:metabolism; D012042:Registries; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides