title: Representativeness of Tuberculosis Genotyping Surveillance in the United States, 2009-2010.
abstract: Genotyping of Mycobacterium tuberculosis isolates contributes to tuberculosis (TB) control through detection of possible outbreaks. However, 20% of U.S. cases do not have an isolate for testing, and 10% of cases with isolates do not have a genotype reported. TB outbreaks in populations with incomplete genotyping data might be missed by genotyping-based outbreak detection. Therefore, we assessed the representativeness of TB genotyping data by comparing characteristics of cases reported during January 1, 2009-December 31, 2010, that had a genotype result with those cases that did not. Of 22,476 cases, 14,922 (66%) had a genotype result. Cases without genotype results were more likely to be patients <19 years of age, with unknown HIV status, of female sex, U.S.-born, and with no recent history of homelessness or substance abuse. Although cases with a genotype result are largely representative of all reported U.S. TB cases, outbreak detection methods that rely solely on genotyping data may underestimate TB transmission among certain groups.
authors.affiliation: Centers for Disease Control and Prevention, Scientific Education and Professional Development Program Office, Atlanta, GA ; Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA.
authors.forename: Emma B
authors.initials: EB
authors.lastname: Shak
authors.affiliation: Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: France
authors.affiliation: Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Cowan
authors.affiliation: Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Starks
authors.affiliation: Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA.
authors.forename: Juliana
authors.initials: J
authors.lastname: Grant
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D062665:Epidemiological Monitoring; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D014376:Tuberculosis / Q000382:microbiology* / Q000635:transmission; D014481:United States