title: Significance of yeasts in bloodstream infection: Epidemiology and predisposing factors of Candidaemia in adult patients at a university hospital (2010-2014).
abstract: The incidence of Candida bloodstream infection (BSI) has increased during the past decades. Species distribution is changing worldwide, and non-albicans Candida spp. are becoming more prevalent. Acquired resistance to antifungal agents has been documented in several reports. The aim of our study was to assess the epidemiology and antifungal susceptibility of Candida isolates from BSI at our institute. The incidence of Candida BSI increased during the first four years of our investigation, from 1.7 to 3.5 episodes / 10 000 admissions, then dropped to 2.66 episodes / 10 000 admissions in the last year. The most frequently isolated species was C. albicans (63%), followed by C. glabrata (13%), C. parapsilosis (10.2%), C. tropicalis (9.3%), and C. krusei (3.7%). One isolate each of C. kefyr, C. fabianii and C. inconspicua were detected. The percentage of C. albicans remained stable throughout the study period. The most frequent risk factors of Candida BSI in our patient population were intensive care treatment (60.4%), abdominal surgery (52.5%), and solid malignancy (30.7%). All isolates were wild-type organisms, no acquired antifungal resistance was detected.
authors.affiliation: Clinical Microbiology Laboratory, Institute of Laboratory Medicine, Semmelweis University , Budapest , Hungary.
authors.forename: Júlia
authors.initials: J
authors.lastname: Pongrácz
authors.affiliation: Clinical Microbiology Laboratory, Institute of Laboratory Medicine, Semmelweis University , Budapest , Hungary.
authors.forename: Emese
authors.initials: E
authors.lastname: Juhász
authors.affiliation: Clinical Microbiology Laboratory, Institute of Laboratory Medicine, Semmelweis University , Budapest , Hungary.
authors.forename: Miklós
authors.initials: M
authors.lastname: Iván
authors.affiliation: Clinical Microbiology Laboratory, Institute of Laboratory Medicine, Semmelweis University , Budapest , Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Kristóf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology*; D002175:Candida / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D058387:Candidemia / Q000453:epidemiology / Q000382:microbiology*; D004198:Disease Susceptibility; D025141:Drug Resistance, Fungal; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult
chemical_list: D000935:Antifungal Agents
keywords: Candida spp.; antifungal susceptibility; bloodstream infection; epidemiology