title: Positive impact of elastography in breast cancer diagnosis: an institutional experience.
abstract: Elastography (ES) is a technique that, when associated with traditional B mode ultrasound (US), allows the degree of elasticity of tissue to be evaluated according to a color scale system. The aims of the study were to compare the diagnostic characteristics of two widely used techniques adopted in breast cancer screening; US and color Doppler (CD), with those of the same two techniques plus ES, and assessment of the same diagnostic characteristics when the three methods were applied to lesions < or >1 cm. Methods used included subjecting 212 women to investigations aimed at the early diagnosis of breast cancer outside the screening model, whereby 395 lesions were detected by US, ES, and CD, with a definitive diagnosis proved by histological exam. The diagnostic performance of US, ES, CD, and their combinations was calculated. The results showed that comparing the diagnostic characteristics of the three methods with reference to the definitive histological results for malignant breast lesions, the best diagnostic accuracy was obtained when US, ES, and CD were combined (0.837). For lesions <1 cm, diagnostic accuracy was 0.782, and for those >1 cm, it was 0.886. In the lesions <1 cm, which were more difficult to study, a positive ES score (>4) appeared to be sufficient to deepen the diagnosis, even though 35 % of the ES or US positive lesions were not malignant. By contrast, in lesions >1 cm, the probability of having a malignant lesion when all three tests were positive was very high (97 %). It was concluded that early diagnosis is a key factor in breast cancer, so an economically sustainable, non-invasive pathway is the target of diagnostic breast imaging.
authors.affiliation: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, "La Sapienza" University of Rome, Via di Grottarossa, 1035/1039, 00189 Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Botticelli
authors.affiliation: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, "La Sapienza" University of Rome, Via di Grottarossa, 1035/1039, 00189 Rome, Italy.
authors.forename: Eva
authors.initials: E
authors.lastname: Mazzotti
authors.affiliation: Department of Pathology, Faculty of Medicine and Psychology, Sant'Andrea Hospital, "La Sapienza" University of Rome, Rome, Italy.
authors.forename: Domenica
authors.initials: D
authors.lastname: Di Stefano
authors.affiliation: Breast Diagnosis and Treatment Unit, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
authors.forename: Viviana
authors.initials: V
authors.lastname: Petrocelli
authors.affiliation: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, "La Sapienza" University of Rome, Via di Grottarossa, 1035/1039, 00189 Rome, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Mazzuca
authors.affiliation: Department of Medical-Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, "La Sapienza" University of Rome, Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: La Torre
authors.affiliation: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, "La Sapienza" University of Rome, Via di Grottarossa, 1035/1039, 00189 Rome, Italy.
authors.forename: Francesca Romana
authors.initials: FR
authors.lastname: Ciabatta
authors.affiliation: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, "La Sapienza" University of Rome, Via di Grottarossa, 1035/1039, 00189 Rome, Italy.
authors.forename: Rosaria Maria
authors.initials: RM
authors.lastname: Giovagnoli
authors.affiliation: Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, "La Sapienza" University of Rome, Via di Grottarossa, 1035/1039, 00189 Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Marchetti
authors.affiliation: Breast Diagnosis and Treatment Unit, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Bonifacino
keywords: Breast cancer; Diagnostic accuracy; Elastography; ROC analysis; Screening