title: Frontal Lobe Function and Risk of Hip Fracture in Patient With Alzheimer Disease: An Analysis of Linked Data.
abstract: To determine the association between frontal lobe function and risk of hip fracture in patients with Alzheimer disease (AD).Retrospective cohort study using multicenter hospital-based dementia registry and national health insurance claim data was done. Participants who had available data of neuropsychological test, national health insurance claim, and other covariates were included. A total of 1660 patients with AD were included based on Stroop Test results. A total of 1563 patients with AD were included based on the Controlled Oral Word Association Test (COWAT) results. Hip fracture was measured by validated identification criteria using national health insurance claim data. Frontal lobe function was measured by Stroop Test and COWAT at baseline.After adjusting for potential covariates, including cognitive function in other domains (language, verbal and nonverbal memory, and attention), the Cox proportional hazard regression analysis revealed that risk of a hip fracture was decreased with a hazard ratio (HR) of 0.98 per one point of increase in the Stroop Test (adjusted HR = 0.98, 95% confidence interval [CI]: 0.97-1.00) and 0.93 per one point increase in COWAT (adjusted HR = 0.93, 95% CI: 0.88-0.99).The risk of hip fracture in AD patients was associated with baseline frontal lobe function. The result of this research presents evidence of association between frontal lobe function and risk of hip fracture in patients with AD.
authors.affiliation: From the Department of Psychiatry, Ajou University School of Medicine, Suwon (HWR, CHH, KJC, YKC, KYL, JSN, SJS); Health Administration, Department of Management & Administration, Backseok Arts University, Seoul (SJL); Department of Preventive Medicine and Public Health, Ajou University School of Medicine (YL); Institute on Aging, Ajou University Medical Center, Suwon (HWR, CHH, YL, KJC, SJS); Department of Psychiatry, CHA University College of Medicine, Gangnam Medical Center and CHAUM Life Center (KSL); Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul (BHO); Department of Neurology, Inha University School of Medicine, Incheon (SHC); Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul (SYK); and Health Insurance Police Research Institute, National Health Insurance Service, Seoul, Republic of Korea (JHB).
authors.forename: Hyun Woong
authors.initials: HW
authors.lastname: Roh
authors.forename: Chang Hyung
authors.initials: CH
authors.lastname: Hong
authors.forename: SooJin
authors.initials: S
authors.lastname: Lee
authors.forename: Yunhwan
authors.initials: Y
authors.lastname: Lee
authors.forename: Kang Soo
authors.initials: KS
authors.lastname: Lee
authors.forename: Ki Jung
authors.initials: KJ
authors.lastname: Chang
authors.forename: Byoung Hoon
authors.initials: BH
authors.lastname: Oh
authors.forename: Seong Hye
authors.initials: SH
authors.lastname: Choi
authors.forename: Seong Yoon
authors.initials: SY
authors.lastname: Kim
authors.forename: Joung Hwan
authors.initials: JH
authors.lastname: Back
authors.forename: Young Ki
authors.initials: YK
authors.lastname: Chung
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Lim
authors.forename: Jai Sung
authors.initials: JS
authors.lastname: Noh
authors.forename: Sang Joon
authors.initials: SJ
authors.lastname: Son
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000523:psychology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006620:Hip Fractures / Q000453:epidemiology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors