title: Spontaneous regression of non-small cell lung cancer that progressed after multiple chemotherapies: A case report.
abstract: Spontaneous regression (SR) of cancer is defined as a complete or partial, temporary or permanent disappearance of all or at least some relevant parameters of malignant disease with inadequate or no treatment. SR of cancer is an extremely rare phenomenon. We report a case of a 67-year-old man who experienced SR of non-small-cell lung cancer (NSCLC), which progressed after fifth-line chemotherapy and regressed after chemotherapy ceased. Surprisingly, the primary tumor size continued to decrease for more than 13 months and his general condition markedly improved after discontinuation of the chemotherapy. To our knowledge, this is the first report of SR in a patient with NSCLC that was not responsive to a fifth round of chemotherapy.
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Chaeuk
authors.initials: C
authors.lastname: Chung
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Park
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea ; Cancer Institute of Chungnam National University Deajeon, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Ju Ock
authors.initials: JO
authors.lastname: Kim
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Jung
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Hee Sun
authors.initials: HS
authors.lastname: Park
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Moon
authors.affiliation: Department of Nuclear Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Min Ji
authors.initials: MJ
authors.lastname: Cho
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Sang Ok
authors.initials: SO
authors.lastname: Jung
authors.affiliation: Department of Pathology, College of Medicine, Chungnam National University Deajeon, Korea.
authors.forename: Choong Sik
authors.initials: CS
authors.lastname: Lee
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, College of Medicine, Chungnam National University Deajeon, Korea ; Cancer Institute of Chungnam National University Deajeon, Korea.
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Lee
keywords: Chemotherapy; non-small cell lung cancer; spontaneous neoplasm regression