title: Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codon.
abstract: A relatively common stop codon (Q20*) was identified in the serotonin 2B receptor gene (HTR2B) in a Finnish founder population in 2010 and it was associated with impulsivity. Here we examine the phenotype of HTR2B Q20* carriers in a setting comprising 14 heterozygous HTR2B Q20* carriers and 156 healthy controls without the HTR2B Q20*. The tridimensional personality questionnaire, Brown-Goodwin lifetime aggression scale, the Michigan alcoholism screening test and lifetime drinking history were used to measure personality traits, impulsive and aggressive behavior, both while sober and under the influence of alcohol, and alcohol consumption. Regression analyses showed that among the HTR2B Q20* carriers, temperamental traits resembled a passive-dependent personality profile, and the presence of the HTR2B Q20* predicted impulsive and aggressive behaviors particularly under the influence of alcohol. Results present examples of how one gene may contribute to personality structure and behaviors in a founder population and how personality may translate into behavior.
authors.affiliation: Department of Psychiatry, University of Helsinki, Institute of Clinical Medicine, Helsinki, Finland.|Research and Development, Rinnekoti Foundation, Espoo, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Tikkanen
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.|Department of Forensic Psychiatry, University of Eastern Finland, Niuvaniemi Hospital, Kuopio, Finland.|National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Tiihonen
authors.affiliation: National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: M R
authors.initials: MR
authors.lastname: Rautiainen
authors.affiliation: Department of Psychiatry, University of Helsinki, Institute of Clinical Medicine, Helsinki, Finland.|National Institute for Health and Welfare, Helsinki, Finland.|Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Paunio
authors.affiliation: Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
authors.forename: L
authors.initials: L
authors.lastname: Bevilacqua
authors.affiliation: Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA.
authors.forename: R
authors.initials: R
authors.lastname: Panarsky
authors.affiliation: Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA.
authors.forename: D
authors.initials: D
authors.lastname: Goldman
authors.affiliation: Department of Psychiatry, University of Helsinki, Institute of Clinical Medicine, Helsinki, Finland.|Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Virkkunen
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000150:complications / Q000235:genetics*; D000374:Aggression; D000428:Alcohol Drinking / Q000235:genetics*; D000437:Alcoholism / Q000150:complications / Q000235:genetics; D018388:Codon, Terminator / Q000235:genetics*; D004644:Emotions; D005260:Female; D005387:Finland; D006801:Humans; D007175:Impulsive Behavior; D008297:Male; D010551:Personality / Q000235:genetics; D044403:Receptor, Serotonin, 5-HT2B / Q000235:genetics*; D012309:Risk-Taking; D011795:Surveys and Questionnaires
chemical_list: D018388:Codon, Terminator; D044403:Receptor, Serotonin, 5-HT2B