title: A Novel Pd-Catalysed Annulation Reaction for the Syntheses of Pyrroloindoles and Pyrroloquinolines.
abstract: Pd-catalysed annulation reactions between indole derivatives and internal alkyne esters leading to various pyrrolo[1,2-a]indoles and pyrroloquinolines have been developed. The strategy involves an intermolecular addition of the indole nitrogen on to the internal alkyne ester followed by an intramolecular insertion of a vinyl-palladium complex into the carbonyl group. This method offers a facile and practical approach to pyrrolo[1,2-a]indoles and pyrroloquinolines.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016 (India). ddethe@iitk.ac.
authors.forename: Dattatraya H
authors.initials: DH
authors.lastname: Dethe
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016 (India).
authors.forename: Raghavender
authors.initials: R
authors.lastname: Boda
keywords: alkynes; annulation; cyclization; heterocycles; palladium