title: The relation of urinary bisphenol A with kisspeptin in girls diagnosed with central precocious puberty and premature thelarche.
abstract: BACKGROUND
  Bisphenol A (BPA) is known as an endocrine disruptor and it is supposed to have a role on the development of central precocious puberty (CPP). Kisspeptin, a hypothalamic peptide, is a neuromodulator of gonadotropin releasing hormone and it has an important role on regulation of the onset of puberty. The BPA levels in girls with CPP and premature thelarche (PT) and its relation with kisspeptin levels were investigated.
  
  
  METHODS
  Twenty-eight girls with CPP, 28 girls with PT and 22 prepubertal girls as a control group were enrolled to the study. Urinary BPA and serum kisspeptin levels were compared in the groups. Bivariate correlations were performed to evaluate the relations of BPA with kisspeptin and estradiol.
  
  
  RESULTS
  There was no statistical difference between groups regarding BPA levels. Serum kisspeptin levels were higher in CPP group than controls [306.56 (interquartile range (IQR), 175.63-504.66) vs. 157.62 (IQR, 55.61-285.00) p: 0.008]. There were no correlations between BPA and kisspeptin levels (r: 0.088, p: 0.391) and between BPA and estradiol (r: -0.171, p: 0.144).
  
  
  CONCLUSIONS
  The BPA levels did not differentiate between groups and it seems that the exposed amount of BPA in daily life did not affect kisspeptin levels in girls with CPP and PT.
authors.forename: İlker Tolga
authors.initials: İT
authors.lastname: Özgen
authors.forename: Emel
authors.initials: E
authors.lastname: Torun
authors.forename: Bilge
authors.initials: B
authors.lastname: Bayraktar-Tanyeri
authors.forename: Erdem
authors.initials: E
authors.lastname: Durmaz
authors.forename: Elif
authors.initials: E
authors.lastname: Kılıç
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Cesur
mesh_terms: D001559:Benzhydryl Compounds / Q000652:urine*; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D059648:Kisspeptins / Q000097:blood*; D008297:Male; D010636:Phenols / Q000652:urine*; D011379:Prognosis; D011629:Puberty, Precocious / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D012741:Sexual Maturation; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D015415:Biomarkers; D059648:Kisspeptins; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds