title: Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature.
abstract: Stromal Vascular Fraction (SVF) is a heterogeneous collection of cells contained within adipose tissue that is traditionally isolated using enzymes such as collagenase. With the removal of adipose cells, connective tissue and blood from lipoaspirate, comes the SVF, a mix including mesenchymal stem cells, endothelial precursor cells, T regulatory cells, macrophages, smooth muscle cells, pericytes and preadipocytes. In part 1 of our 2-part series, we review the literature with regards to the intensifying interest that has shifted toward this mixture of cells, particularly due to its component synergy and translational potential. Trials assessing the regenerative potential of cultured Adipose Derived Stem Cells (ADSCs) and SVF demonstrate that SVF is comparably effective in treating conditions ranging from radiation injuries, burn wounds and diabetes, amongst others. Aside from their use in chronic conditions, SVF enrichment of fat grafts has proven a major advance in maintaining fat graft volume and viability. Many SVF studies are currently in preclinical phases or are moving to human trials. Overall, regenerative cell therapy based on SVF is at an early investigative stage but its potential for clinical application is enormous.
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Nguyen
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, USA.
authors.forename: James
authors.initials: J
authors.lastname: Guo
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, USA.
authors.forename: Derek A
authors.initials: DA
authors.lastname: Banyard
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, USA.
authors.forename: Darya
authors.initials: D
authors.lastname: Fadavi
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, USA.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Toranto
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, USA.
authors.forename: Garrett A
authors.initials: GA
authors.lastname: Wirth
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, USA.
authors.forename: Keyianoosh Z
authors.initials: KZ
authors.lastname: Paydar
authors.affiliation: Department of Plastic Surgery, University of California, Irvine, USA.
authors.forename: Gregory R D
authors.initials: GR
authors.lastname: Evans
authors.affiliation: Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, USA. Electronic address: awidgero@uci.edu.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Widgerow
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology*; D006801:Humans; D017154:Stromal Cells / Q000637:transplantation*
keywords: Adipose derived stem cells; Preadipocytes; Progenitor cells; Stem cell regeneration; Stromal vascular fraction