title: Change in Physical Activity and Sedentary Time Associated With 2-Year Weight Loss in Obese Adults With Osteoarthritis.
abstract: We examined if changes in moderate-to-vigorous physical activity (MVPA), light activity, and sedentary behavior are related to weight change over a 2-year period in obese adults with/elevated risk for knee osteoarthritis.
  
  
  
  Weight, physical activity, and sedentary time at baseline and 2 years were obtained from 459 obese participants from the Osteoarthritis Initiative. Weight change was categorized as ≥ 10 lbs, 5.0 to 9.9 lbs, 4.9 to -4.9 lbs, -5.0 to -9.9 lbs, and ≤ -10 lbs. We examined the association between 2-year weight change categories and changes in activity/sedentary time from accelerometer monitoring by multiple linear regression adjusted for baseline weight, demographic, and health factors.
  
  
  
  Across the 5 weight categories (loss to gain), average 2-year change ranged from -7.4 to 28.0 sedentary minutes/ day, 4.2 to -23.1 light activity minutes/day, and 3.2 to -4.9 MVPA minutes/day, respectively. Higher weight loss categories were separately associated with increased MVPA (P for trend < 0.001) and less sedentary gain (P for trend = 0.01). Weight loss categories had a strong trend with light activity gain but not statistically significant (P for trend = 0.06).
  
  
  
  Small increases in MVPA and decreases in sedentary time over 2 years were associated with weight loss among adults with obesity and with or at elevated risk for knee osteoarthritis.
authors.affiliation: Dept of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL.
authors.forename: Christine A
authors.initials: CA
authors.lastname: Pellegrini
authors.forename: Jing
authors.initials: J
authors.lastname: Song
authors.forename: Rowland W
authors.initials: RW
authors.lastname: Chang
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Semanik
authors.forename: Jungwha
authors.initials: J
authors.lastname: Lee
authors.forename: Linda
authors.initials: L
authors.lastname: Ehrlich-Jones
authors.forename: Daniel
authors.initials: D
authors.lastname: Pinto
authors.forename: Dorothy D
authors.initials: DD
authors.lastname: Dunlop
mesh_terms: D000054:Acceleration; D061725:Accelerometry; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D020370:Osteoarthritis, Knee / Q000150:complications / Q000503:physiopathology*; D012044:Regression Analysis; D057185:Sedentary Behavior; D015430:Weight Gain; D015431:Weight Loss