title: Pulmonary valve replacement and quality-of-life assessment.
abstract: BACKGROUND
  Chronic pulmonary regurgitation is common after repair of tetralogy of Fallot. Despite the deleterious effects of chronic pulmonary regurgitation on right ventricular function, many patients with repaired tetralogy of Fallot remain asymptomatic. Health is defined not only by the absence of disease but also by physical, mental, and social wellbeing. We sought to examine the impact of pulmonary valve replacement on quality of life in asymptomatic patients with repaired tetralogy of Fallot and chronic pulmonary regurgitation.
  
  
  METHODS
  From January 2009 to December 2012, 25 (18 male) asymptomatic patients (mean age 23.4 ± 7.4 years) who underwent pulmonary valve replacement for significant pulmonary regurgitation were recruited. Cardiac magnetic resonance was performed pre- and postoperatively. Quality of life was assessed using the Chinese version of the SF-36v2 evaluation tool. Demographics, clinical data, magnetic resonance findings, and quality-of-life scores were collected and calculated for comparison.
  
  
  RESULTS
  After surgery, the indexed right ventricular end-diastolic volume (193 ± 47.3 vs. 105.6 ± 29.6 mL m(-2), p < 0.001) and indexed right ventricular end-systolic volume (108.5 ± 32.9 vs. 61.1 ± 23 mL m(-2), p < 0.001) decreased significantly. The response rates for pre- and postoperative quality-of-life assessments were 100%. Patients demonstrated improvements in all 8 domains of the SF-36v2 assessment. The physical (46.5 ± 6.6 vs. 49.9 ± 6.4, p = 0.012) and mental (43.7 ± 7.8 vs. 51.9 ± 7.6, p < 0.001) component summary scores increased after surgery.
  
  
  CONCLUSIONS
  Pulmonary valve replacement can improve the quality of life in patients with chronic asymptomatic pulmonary regurgitation.
authors.affiliation: Department of Cardiothoracic Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Flora H F
authors.initials: FH
authors.lastname: Tsang
authors.affiliation: Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: Sophia J
authors.initials: SJ
authors.lastname: Wong
authors.affiliation: Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China xfcheung@hku.hk.
authors.forename: Yiu-fai
authors.initials: YF
authors.lastname: Cheung
mesh_terms: D000293:Adolescent; D000328:Adult; D058070:Asymptomatic Diseases; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008603:Mental Health; D011664:Pulmonary Valve / Q000503:physiopathology / Q000601:surgery*; D011665:Pulmonary Valve Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D011788:Quality of Life; D020127:Recovery of Function; D013318:Stroke Volume; D011795:Surveys and Questionnaires; D013771:Tetralogy of Fallot / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D016278:Ventricular Function, Right; D055815:Young Adult
keywords: Health status indicators; Heart valve prosthesis implantation; Postoperative complications; Pulmonary valve insufficiency; Quality of life; Tetralogy of Fallot