title: [Causal analysis and impact of a systematic error detected about consumption associated with trastuzumab].
abstract: OBJECTIVE
  determine the cause of the constant difference between the theoretical and real number of trastuzumab units consumed in an Intravenous Mixtures Unit.
  
  
  METHODS
  was studied the manual and electronic full procedure about preparing mixtures with trastuzumab. Was performed by visual observation and review of quantitative monitoring data from the electronic preparation support and safe system of the application Farmis-Oncofarm®.
  
  
  RESULTS
  difference between the optimum volume of trastuzumab contained in the summary of product characteristics and the same included in Farmis_Oncofarm® was found. Also found a defect of the optimum volume of 10ml syringes used in the reconstitution vials process.
  
  
  CONCLUSIONS
  the default in the optimal volume of 10ml syringes used in the reconstitution process increases the real consumed units of trastuzumab. This produces a significant economic impact calculated in an annual additional cost in approximately 46.508 € without negative consequences for the patient.
authors.affiliation: Servicio de Farmacia Hospital Universitario Sant Joan, Alicante. España.. bujaldonquerejetanuria@gmail.com.
authors.forename: Nuria
authors.initials: N
authors.lastname: Bujaldón Querejeta
authors.affiliation: Servicio de Farmacia Hospital Universitario Sant Joan, Alicante. España.. bujaldonquerejetanuria@gmail.com.
authors.forename: Dolores
authors.initials: D
authors.lastname: Camacho Romera
authors.affiliation: Servicio de Farmacia Hospital Universitario Sant Joan, Alicante. España.. bujaldonquerejetanuria@gmail.com.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Pomares Pastor
authors.affiliation: Servicio de Farmacia Hospital Universitario Sant Joan, Alicante. España.. bujaldonquerejetanuria@gmail.com.
authors.forename: María
authors.initials: M
authors.lastname: Sánchez Garnes
authors.affiliation: Servicio de Farmacia Hospital Universitario Sant Joan, Alicante. España.. bujaldonquerejetanuria@gmail.com.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Martínez Ramírez
authors.affiliation: Servicio de Farmacia Hospital Universitario Sant Joan, Alicante. España.. bujaldonquerejetanuria@gmail.com.
authors.forename: Mercedes
authors.initials: M
authors.lastname: González Delgado
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding; D055695:Electronic Prescribing; D006801:Humans; D015588:Observer Variation; D015203:Reproducibility of Results; D013594:Syringes; D000068878:Trastuzumab / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000068878:Trastuzumab