title: Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: a meta-analysis.
abstract: OBJECTIVE
  Catechol-O-methyltransferase (COMT) is one of the major degradative pathways of dopamine and COMT Val/Met polymorphisms are associated with the enzyme activity, which is related to dopamine involvement in the nicotine addiction process. However, the reported results of several genetic studies are not consistent.
  
  
  METHODS
  We reviewed the smoking cessation outcomes among previously reported studies by comparing COMT polymorphism. A total of five studies were assessed in the present meta-analysis and the Met/Met, Val/Met or Val/Val genotype were compared with respect to smoking cessation outcomes.
  
  
  RESULTS
  As the results, any significant association between COMT polymorphism and smoking cessation were not observed. In the subgroup analysis for evaluating the association between COMT polymorphism and smoking cessation therapy, three studies were assessed by comparing two groups (Met/Met vs Val/Met plus Val/Val). A significant association between COMT polymorphism and smoking cessation was observed (odds ratio: 1.871 and 95% CI: 1.382-2.534).
  
  
  CONCLUSIONS
  The COMT polymorphisms are associated with the outcomes following smoking cessation treatment with nicotine.
authors.affiliation: College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan 712-749, Gyeongsangbuk-do, Republic of Korea.
authors.forename: Hye Duck
authors.initials: HD
authors.lastname: Choi
authors.affiliation: College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
authors.forename: Wan Gyoon
authors.initials: WG
authors.lastname: Shin
mesh_terms: D002394:Catechol O-Methyltransferase / Q000235:genetics*; D056726:Genetic Association Studies / Q000379:methods; D005838:Genotype; D006801:Humans; D008715:Methionine / Q000235:genetics*; D009538:Nicotine / Q000008:administration & dosage*; D012907:Smoking / Q000188:drug therapy / Q000235:genetics*; D016540:Smoking Cessation / Q000379:methods; D016896:Treatment Outcome; D014633:Valine / Q000235:genetics*
chemical_list: D009538:Nicotine; D008715:Methionine; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase; D014633:Valine
keywords: COMT; gene polymorphism; meta-analysis; smoking cessation