title: Immune correlates for dengue vaccine development.
abstract: Dengue virus is the leading cause of vector-borne viral disease with four serotypes in circulation. Vaccine development has been complicated by the potential for both protection and disease enhancement during heterologous infection. Secondary infection triggers cross-reactive immune memory responses that have varying functional and epitope specificities that determine protection or risk. Strongly neutralizing antibodies to quaternary epitopes may be especially important for virus neutralization. Cell-mediated immunity dominated by Th1 functions may also play an important role. Determining an immune correlate of protection or risk would be highly beneficial for vaccine development but is hampered by mechanistic uncertainties and assay limitations. Clinical efficacy trials and human infection models along with a systems approach may provide future opportunities to elucidate such correlates.
authors.affiliation: a Division of Infectious Diseases and Immunology, Department of Medicine , University of Massachusetts Medical School , Worcester , MA , USA.
authors.forename: Anon
authors.initials: A
authors.lastname: Srikiatkhachorn
authors.affiliation: b Dengue Vaccine Initiative , International Vaccine Institute, SNU Research Park , Seoul , Korea.
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Yoon
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D015415:Biomarkers; D002986:Clinical Trials as Topic; D003715:Dengue / Q000276:immunology* / Q000473:pathology* / Q000517:prevention & control; D053059:Dengue Vaccines / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D055808:Drug Discovery / Q000379:methods*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D018417:Th1 Cells / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D015415:Biomarkers; D053059:Dengue Vaccines; D000939:Epitopes
keywords: Dengue; antibody-dependent enhancement; cell-mediated immunity; correlate of protection; correlate of risk; dengue vaccine; human infection model; humoral immunity; systems immunology; systems vaccinology