title: Acute Hemorrhagic Edema of Infancy: an unusual diagnosis for the general pediatrician.
abstract: Acute Hemorrhagic Edema of Infancy (AHEI) is a rare leukocytoclastic vasculitis, clinically characterized by the classical triad: palpable purpuric skin lesions, edema and fever, and is commonly misdiagnosed as Henoch-Schönlein purpura. In addition to its sudden onset, AHEI is also characterized by its self-limited course with complete and spontaneous recovery occurring between 1 and 3 weeks. Because of the scarcity of studies on therapy with corticosteroids, the conservative approach is usually recommended. The authors report an unusual case of an one-year-old boy who presented with typical cutaneous rash of AHEI and orchitis, the latter showing complete resolution after less than 24 hours of prednisolone therapy. The authors call attention to this entity mainly as a differential diagnosis of Henoch-Schönlein purpura and to the importance of new studies to establish the benefits of corticosteroid therapy for AHEI.
authors.affiliation: Department of Pediatrics - Hospital das Clínicas - Faculty of Medicine - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Diego Fontana Siqueira
authors.initials: DF
authors.lastname: Cunha
authors.affiliation: Faculty of Medicine - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Ana Letícia Fornazieri
authors.initials: AL
authors.lastname: Darcie
authors.affiliation: Faculty of Medicine - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Gabriel Nuncio
authors.initials: GN
authors.lastname: Benevides
authors.affiliation: Division of Pediatrics - Hospital Universitário - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Angela Espósito
authors.initials: AE
authors.lastname: Ferronato
authors.affiliation: Division of Pediatrics - Hospital Universitário - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Noely
authors.initials: N
authors.lastname: Hein
authors.affiliation: Division of Pediatrics - Hospital Universitário - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Denise Swei
authors.initials: DS
authors.lastname: Lo
authors.affiliation: Division of Pediatrics - Hospital Universitário - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Cristina Ryoka Miyao
authors.initials: CR
authors.lastname: Yoshioka
authors.affiliation: Division of Pediatrics - Hospital Universitário - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Maki
authors.initials: M
authors.lastname: Hirose
authors.affiliation: Division of Pediatrics - Hospital Universitário - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Debora Morais
authors.initials: DM
authors.lastname: Cardoso
authors.affiliation: Faculty of Medicine - Universidade de São Paulo, São Paulo/SP - Brazil . ; Division of Pediatrics - Hospital Universitário - Universidade de São Paulo, São Paulo/SP - Brazil .
authors.forename: Alfredo Elias
authors.initials: AE
authors.lastname: Gilio
keywords: Infant; Orchitis; Purpura; Steroids; Vasculitis, Leukocytoclastic, Cutaneous