title: [Mean platelet volume play a role in disease severity in patients with obstructive sleep apnea syndrome?].
abstract: OBJECTIVE
  This study aims to show the effects of nasal continuous positive airway pressure (CPAP) treatment on platelet activation in patients with severe obstructive sleep apnea syndrome (OSAS).
  
  
  METHODS
  Forty-six patients (29 males, 17 females; mean age 48.2±7.6 years; range 40 to 56 years) with severe OSAS with apnea/hypopnea index (AHI) ≥30 were included in this study. Complete blood counts were analyzed and mean platelet volume (MPV) values were compared in patients before and after CPAP treatment at six months.
  
  
  RESULTS
  The mean MPV values before CPAP were 8.9±1.3 (p<0.001), while the mean values were 7.7±1.1 (p<0.001) at six months after CPAP treatment in patients with severe OSAS. There was a statistically significant decrease in the MPV values after CPAP treatment. Patients' number of platelets which was measured six months after the CPAP treatment increased at a significant level compared to baseline (p<0.001).
  
  
  CONCLUSIONS
  Continuous positive airway pressure treatment caused a significant decrease in the MPV values in patients with severe OSAS. As a negative acute phase reactant, MPV can be used as a marker to exert the cardioprotective effect of CPAP.
authors.affiliation: Department of Otolaryngology, Kocaeli Derince Training and Research Hospital, 41900 Derince, Kocaeli. Turkey. drerkanesen@hotmail.com.
authors.forename: Erkan
authors.initials: E
authors.lastname: Esen
authors.forename: Fatih
authors.initials: F
authors.lastname: Özdoğan
authors.forename: Halil Erdem
authors.initials: HE
authors.lastname: Özel
authors.forename: Zahide
authors.initials: Z
authors.lastname: Yılmaz
authors.forename: Turgut
authors.initials: T
authors.lastname: Yüce
authors.forename: Serdar
authors.initials: S
authors.lastname: Başer
authors.forename: Selahattin
authors.initials: S
authors.lastname: Genç
authors.forename: Adin
authors.initials: A
authors.lastname: Selçuk
mesh_terms: D000328:Adult; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods; D008875:Middle Aged; D017286:Polysomnography; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000503:physiopathology / Q000628:therapy