title: MDM2 T309G polymorphism and esophageal cancer risk: a meta-analysis.
abstract: Murine double minute 2 (MDM2) has suggested to play an important role in esophageal cancer. The association between MDM2 T309G polymorphism and esophageal cancer risk was inconclusive. To clarify the possible association, we conducted a meta-analysis. We searched in the PubMed, Embase, and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. A total of 6 studies with 4909 cases and controls were included based on the search criteria. The MDM2 T309G polymorphism was associated with a significantly decreased risk of esophageal cancer (OR=0.88; 95% CI, 0.81-0.96; I(2)=22%). When stratified by type of race, a significantly decreased esophageal cancer risk were observed in Asians (OR=0.85; 95% CI, 0.78-0.93; I(2)=0%). In conclusion, this meta-analysis suggested that MDM2 T309G polymorphism was associated with a significantly decreased risk of esophageal cancer.
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Tecnology Luoyang 471003, Henan, China.
authors.forename: Caipeng
authors.initials: C
authors.lastname: Lei
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Tecnology Luoyang 471003, Henan, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Tecnology Luoyang 471003, Henan, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Tecnology Luoyang 471003, Henan, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Qiao
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Tecnology Luoyang 471003, Henan, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Tecnology Luoyang 471003, Henan, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Henan University of Science and Tecnology Luoyang 471003, Henan, China.
authors.forename: Chunling
authors.initials: C
authors.lastname: Zhao
keywords: Esophageal cancer; MDM2; meta-analysis; polymorphism