title: Fluorogenic nanoreactor assembly with boosted sensing kinetics for timely imaging of cellular hydrogen peroxide.
abstract: The precise detection of endogenous H2O2 has been considered to be a useful tool for understanding cell physiology. Here, we have developed a nanoreactor co-incorporated with a H2O2-responsive fluorogenic molecule and a catalytic additive. The fast sensing kinetics allows us to visualize a subcellular response in real-time.
authors.affiliation: Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr and Department of Material Science and Engineering, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-744, Korea. parksy@snu.ac.kr.
authors.forename: Jeongyun
authors.initials: J
authors.lastname: Heo
authors.affiliation: Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
authors.forename: Chang-Keun
authors.initials: CK
authors.lastname: Lim
authors.affiliation: Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
authors.forename: Youngsun
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr and Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea.
authors.forename: Yong-Deok
authors.initials: YD
authors.lastname: Lee
authors.affiliation: Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
authors.forename: Joon-ho
authors.initials: JH
authors.lastname: Maeng
authors.affiliation: Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
authors.forename: Dae-Ro
authors.initials: DR
authors.lastname: Ahn
authors.affiliation: Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
authors.forename: Sangyoup
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea.
authors.forename: Joona
authors.initials: J
authors.lastname: Bang
authors.affiliation: Department of Material Science and Engineering, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-744, Korea. parksy@snu.ac.kr.
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Park
authors.affiliation: Center for Theragnosis, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea. sehoonkim@kist.re.kr.
authors.forename: Sehoon
authors.initials: S
authors.lastname: Kim
mesh_terms: D019149:Bioreactors; D002460:Cell Line; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007700:Kinetics; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology; D013050:Spectrometry, Fluorescence
chemical_list: D006861:Hydrogen Peroxide