title: The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer.
abstract: Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as targets for potential anticancer drugs. Cap-dependent translation starts when eIF4E binds to mRNA cap domain. This review will present eIF4E's structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer.
authors.affiliation: INSERM, U1068, CRCM, Marseille, France; Institut Paoli-Calmettes, Marseille, France; Aix-Marseille University, Marseille, France; CNRS, UMR7258, Marseille, France.
authors.forename: Sara
authors.initials: S
authors.lastname: Karaki
authors.affiliation: INSERM, U1068, CRCM, Marseille, France; Institut Paoli-Calmettes, Marseille, France; Aix-Marseille University, Marseille, France; CNRS, UMR7258, Marseille, France.
authors.forename: Claudia
authors.initials: C
authors.lastname: Andrieu
authors.affiliation: INSERM, U1068, CRCM, Marseille, France; Institut Paoli-Calmettes, Marseille, France; Aix-Marseille University, Marseille, France; CNRS, UMR7258, Marseille, France.
authors.forename: Hajer
authors.initials: H
authors.lastname: Ziouziou
authors.affiliation: INSERM, U1068, CRCM, Marseille, France; Institut Paoli-Calmettes, Marseille, France; Aix-Marseille University, Marseille, France; CNRS, UMR7258, Marseille, France. Electronic address: palma.rocchi@inserm.fr.
authors.forename: Palma
authors.initials: P
authors.lastname: Rocchi
mesh_terms: D039561:Eukaryotic Initiation Factor-4E / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D011487:Protein Conformation; D012333:RNA, Messenger / Q000096:biosynthesis; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic
chemical_list: D039561:Eukaryotic Initiation Factor-4E; D012333:RNA, Messenger
keywords: Cancer; Therapeutic target; eIF4E