title: A rare case of ulcerative colitis exacerbated by VZV infection.
abstract: A 16-years old man with severe ulcerative colitis (UC) was admitted to our hospital. After initiating treatment with corticosteroid for UC, chicken pox appeared. At the same time of appearance of chicken pox, the disease activity of UC was exacerbated. After initiating the treatment with acyclovir, both chicken pox and UC improved. Because colonoscopic findings revealed the remaining of moderately active UC, initiating the treatment with infliximab could induce clinical remission of UC without relapse of varicella-zoster virus (VZV) infection. This is a very rare case of UC with concomitant VZV infection. According to our report, the vaccination for VZV prior to immunosuppressive treatments would be necessary for VZV naïve patients with UC.
authors.affiliation: Division of Gastroenterology and Hepatology, Digestive Disease Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimach, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishimura
authors.affiliation: Division of Gastroenterology and Hepatology, Digestive Disease Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimach, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yoshino
authors.affiliation: Division of Gastroenterology and Hepatology, Digestive Disease Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimach, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Fujikawa
authors.affiliation: Division of Gastroenterology and Hepatology, Digestive Disease Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimach, Kita-ku, Osaka, 530-8480, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Division of Gastroenterology and Hepatology, Digestive Disease Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20 Ohgimach, Kita-ku, Osaka, 530-8480, Japan. s-yazumi@kitano-hp.or.jp.
authors.forename: Shujiro
authors.initials: S
authors.lastname: Yazumi
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use; D002644:Chickenpox / Q000150:complications* / Q000188:drug therapy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D003113:Colonoscopy; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D000069285:Infliximab / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D000998:Antiviral Agents; D005765:Gastrointestinal Agents; D005938:Glucocorticoids; D011239:Prednisolone; D000069285:Infliximab; D000212:Acyclovir; D008775:Methylprednisolone
keywords: Aciclovir; Ulcerative colitis; Varicella-zoster virus