title: Molecular identification and susceptibility of clinically relevant Scedosporium spp. in China.
abstract: As various new sibling species within the Scedosporium spp. have been described recently, this study was conducted to investigate distribution and antifungal susceptibility profiles of the different species of Scedosporium spp. in China. Twenty-one clinical strains of Scedosporium from China and two strains from Japan were reidentified by MLSA. The analysis included BT2, CAL, RPB, SOD, and ACT and the combination of the five loci. Pseudallescheria boydii complex (17 strains) and S. apiospermum (6 strains) were identified. P. boydii complex included four closely related subgroups: P. boydii (9 strains), P. ellipsoidea (6 strains), P. fusoidea (1 strain), and P. angusta (1 strain). There were no significant differences in MICs for neither VOR, POS, nor AMB over all the five species in study. For itraconazole, intraspecific diversity was evident.
authors.affiliation: Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing 100034, China ; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing 100034, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing 100034, China ; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing 100034, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wan
authors.affiliation: Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing 100034, China ; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing 100034, China.
authors.forename: Ruoyu
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Dermatology, Central Hospital of Xiangyang, Hubei College of Arts and Science, Hubei 441021, China.
authors.forename: Qiaoyun
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing 100034, China ; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing 100034, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yu
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage*; D002681:China; D025141:Drug Resistance, Fungal / Q000235:genetics*; D006801:Humans; D021681:Scedosporium / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D013045:Species Specificity
chemical_list: D000935:Antifungal Agents