title: Different regulation of Toll-like receptor 4 expression on blood CD14(+) monocytes by simvastatin in patients with sepsis and severe sepsis.
abstract: We have demonstrated that regulation of Toll-like receptor 4 (TLR4) surface expression levels on blood CD14(+) monocytes by simvastatin treatment in patient with sepsis is different from that in patients with severe sepsis. In patients with sepsis simvastatin treatment statistically significantly decreased TLR4 surface expression level on blood CD14(+) monocytes, while in patients with severe sepsis simvastatin treatment had no significant influence on TLR4 surface expression level on blood CD14(+) monocytes. The changes of plasma interleukin-6 (IL-6) induced by simvastatin in patients with sepsis and severe sepsis were similar with that of TLR4. Our results indicated simvastatin treatment differently influenced inflammation process in patients with sepsis and severe sepsis, which might partially explain the discrepancy, presented by previous trials, about the therapeutic effects of simvastatin treatment in patients with sepsis and severe sepsis.
authors.affiliation: Department of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.
authors.forename: Huanzhang
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.
authors.forename: Cunzhen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.
authors.forename: Wenliang
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.
authors.forename: Xiaopei
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.
authors.forename: Zhisong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.
authors.forename: Huifeng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine (Intensive Care Unit, ICU), Henan Provincial People's Hospital Zhengzhou 450003, China.
authors.forename: Bingyu
authors.initials: B
authors.lastname: Qin
keywords: Sepsis; Toll-like receptor 4; interleukin-6; severe sepsis; simvastatin