title: Early development of the fetal central sulcus on 7.0T magnetic resonance imaging.
abstract: In the previous studies, the criterion for deciding the occurrence time of the fetal central sulcus (CS) on magnetic resonance imaging (MRI) is based on the observation by the eyes. There have been no existing quantitative standards or numerical criteria in this field. In this study, we reconstructed the three-dimension (3D) images of the fetal brain based on the 7.0T MR images of 45 Chinese fetal specimens from the 11 to 22 weeks of gestational age (GA). Then we obtained data by measuring the maximum depth and length of the CS so as to analyze the early developmental pattern of it. These measures, especially CS depth, can be used to quantitatively determine the time of emergence of the fetal CS during the development. Statistics show that there are no gender or interhemispheric asymmetries of the CS from GA of 11 to 22 weeks.
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong 250012, China; Department of Anatomy, Taishan Medical University, Taian, Shandong 271016, China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
authors.forename: Zhonghe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong 250012, China; Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xuntao
authors.initials: X
authors.lastname: Yin
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong 250012, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Zhan
authors.affiliation: Department of Anatomy, Taishan Medical University, Taian, Shandong 271016, China.
authors.forename: Zhenmei
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong 250012, China.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Anatomy, Jining Medical University, Jining, Shandong 272067, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong 250012, China. Electronic address: liusw@sdu.edu.cn.
authors.forename: Shuwei
authors.initials: S
authors.lastname: Liu
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong 250012, China; Research Institute of Clinical Anatomy of Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address: zhszh@fimu.com.
authors.forename: Shizhen
authors.initials: S
authors.lastname: Zhong
mesh_terms: D000367:Age Factors; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000196:embryology*; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D005333:Fetus / Q000033:anatomy & histology; D007839:Functional Laterality; D005865:Gestational Age; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D012737:Sex Factors
keywords: Brain development; Central sulcus; Cerebral cortex; Fetus; MRI; Quantitative standard