title: Nutritional predictors of successful chronic disease prevention for a community cohort in Central Australia.
abstract: To investigate biomarkers of nutrition associated with chronic disease absence for an Aboriginal cohort.
  
  
  
  Screening for nutritional biomarkers was completed at baseline (1995). Evidence of chronic disease (diabetes, CVD, chronic kidney disease or hypertension) was sought from primary health-care clinics, hospitals and death records over 10 years of follow-up. Principal components analysis was used to group baseline nutritional biomarkers and logistic regression modelling used to investigate associations between the principal components and chronic disease absence.
  
  
  
  Three Central Australian Aboriginal communities.
  
  
  
  Aboriginal people (n 444, 286 of whom were without chronic disease at baseline) aged 15-82 years.
  
  
  
  Principal components analysis grouped twelve nutritional biomarkers into four components: 'lipids'; 'adiposity'; 'dietary quality'; and 'habitus with inverse quality diet'. For the 286 individuals free of chronic disease at baseline, lower adiposity, lower lipids and better dietary quality components were each associated with the absence at follow-up of most chronic diseases examined, with the exception of chronic kidney disease. Low 'adiposity' component was associated with absence of diabetes, hypertension and CVD at follow-up. Low 'lipid' component was associated with absence of hypertension and CVD, and high 'dietary quality' component was associated with absence of CVD at follow-up.
  
  
  
  Lowering or maintenance of the factors related to 'adiposity' and 'lipids' to healthy thresholds and increasing access to a healthy diet appear useful targets for chronic disease prevention for Aboriginal people in Central Australia.
authors.affiliation: 1Onemda Group,Indigenous Health Equity Unit,Centre for Health Equity,Melbourne School of Population & Global Health,University of Melbourne,4/207 Bouverie Street,Carlton South,VIC 3053,Australia.
authors.forename: Joanne N
authors.initials: JN
authors.lastname: Luke
authors.affiliation: 1Onemda Group,Indigenous Health Equity Unit,Centre for Health Equity,Melbourne School of Population & Global Health,University of Melbourne,4/207 Bouverie Street,Carlton South,VIC 3053,Australia.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Ritte
authors.affiliation: 1Onemda Group,Indigenous Health Equity Unit,Centre for Health Equity,Melbourne School of Population & Global Health,University of Melbourne,4/207 Bouverie Street,Carlton South,VIC 3053,Australia.
authors.forename: Kerin
authors.initials: K
authors.lastname: O'Dea
authors.affiliation: 2Wardliparingga Aboriginal Research Unit,South Australian Health and Medical Research Institute,Adelaide,South Australia,Australia.
authors.forename: Alex
authors.initials: A
authors.lastname: Brown
authors.affiliation: 3Melbourne School of Population & Global Health,University of Melbourne,Carlton South,Victoria,Australia.
authors.forename: Leonard S
authors.initials: LS
authors.lastname: Piers
authors.affiliation: 4NHMRC Clinical Trials Centre,University of Sydney,Camperdown,New South Wales,Australia.
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Jenkins
authors.affiliation: 1Onemda Group,Indigenous Health Equity Unit,Centre for Health Equity,Melbourne School of Population & Global Health,University of Melbourne,4/207 Bouverie Street,Carlton South,VIC 3053,Australia.
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Rowley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia; D002908:Chronic Disease / Q000517:prevention & control*; D015331:Cohort Studies; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
keywords: Aboriginal; Chronic disease; Nutrition; Prevention