title: Long-term remission of therapy-related acute myeloid leukemia with a new t(11;18)(q23;q21.2) translocation and KMT2A-ME2 (MLL-ME2) fusion gene.
abstract: We describe a unique case of a woman with acute myeloid leukemia with a new, previously undescribed translocation, t(11;18)(q23;q21.2), affecting the KMT2A (MLL) gene and resulting in an KMT2A(MLL)-ME2 fusion. This disease occurred secondarily following chemotherapy for a different acute myeloid leukemia with the recurrent genetic abnormality inv(16)(p13.1;q22). The secondary leukemia was treated with intensive chemotherapy without allogeneic hematopoietic cell transplantation. Complete remission lasting more than 10 years has been achieved with concurrent and sustained remission of the primary leukemia.
authors.affiliation: Department of Hemato-oncology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Szotkowski
authors.affiliation: Department of Hemato-oncology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic. Electronic address: marie.jarosova@fnol.cz.
authors.forename: Marie
authors.initials: M
authors.lastname: Jarošová
authors.affiliation: Childhood Leukemia Investigation Prague (CLIP), Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, Czech Republic.
authors.forename: Olga
authors.initials: O
authors.lastname: Zimmermannová
authors.affiliation: Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt, Frankfurt/Main, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Meyer
authors.affiliation: Department of Biochemistry, Chemistry and Pharmacy, Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia (DCAL), Goethe-University of Frankfurt, Frankfurt/Main, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Marschalek
authors.affiliation: Childhood Leukemia Investigation Prague (CLIP), Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Zuna
authors.affiliation: Department of Hemato-oncology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic.
authors.forename: Jaromír
authors.initials: J
authors.lastname: Hubáček
authors.affiliation: Department of Hemato-oncology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic.
authors.forename: Karel
authors.initials: K
authors.lastname: Indrák
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D003561:Cytarabine; D020732:Cytogenetic Analysis; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D008291:Malate Dehydrogenase / Q000235:genetics*; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D016879:Salvage Therapy; D014178:Translocation, Genetic; D014740:Vidarabine / Q000031:analogs & derivatives
chemical_list: C497422:KMT2A protein, human; D015514:Oncogene Proteins, Fusion; D003561:Cytarabine; D016179:Granulocyte Colony-Stimulating Factor; D051788:Myeloid-Lymphoid Leukemia Protein; D008291:Malate Dehydrogenase; C495394:malic enzyme 2; human; D011495:Histone-Lysine N-Methyltransferase; D014740:Vidarabine
keywords: KMT2A; MLL gene rearrangement; Therapy-related acute myeloid leukemia; inv(16); long-term remission