title: Copper-mediatedN-Arylation of Methyl 2-Aminothiophene-3-carboxylate with Organoboron Reagents.
abstract: A practical protocol for the synthesis ofN-arylated methyl 2-aminothiophene-3-carboxylate has been developedviaChan-Lam cross-coupling. The desired products were synthesized by cross-coupling of methyl 2-aminothiophene-3-carboxylate with both arylboronic acids and potassium aryltrifluoroborate salts in moderate to good yields. A broad range of functional groups was well tolerated.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States ; Department of Chemistry, Government College University, Faisalabad 38000, Pakistan.
authors.forename: Komal
authors.initials: K
authors.lastname: Rizwan
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States ; Department of Chemistry, Faculty of Sciences and Letters, Osmaniye Korkut Ata University, 80000 Osmaniye, Turkey.
authors.forename: Idris
authors.initials: I
authors.lastname: Karakaya
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
authors.forename: Drew
authors.initials: D
authors.lastname: Heitz
authors.affiliation: Department of Chemistry, Government College University, Faisalabad 38000, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zubair
authors.affiliation: Department of Chemistry, Government College University, Faisalabad 38000, Pakistan.
authors.forename: Nasir
authors.initials: N
authors.lastname: Rasool
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
keywords: amine; aryltrifluoroborate; carboxylate; copper; cross-coupling; thiophene