title: Pharmacological significance of the interplay between angiotensin receptors: MAS receptors as putative final mediators of the effects elicited by angiotensin AT1 receptors antagonists.
abstract: The interplay between angiotensin AT1 receptors and MAS receptors relies on several inward regulatory mechanisms from renin-angiotensin system (RAS) including the functional crosstalk between angiotensin II and angiotensin-(1-7), the competitive AT1 antagonism exhibited by angiotensin-(1-7), the antagonist feature assigned to AT1/MAS heterodimerization on AT1 signaling and the AT1-mediated downregulation of angiotensin-converting enzyme 2 (ACE2). Recently, such interplay has acquired an important significance to RAS Pharmacology since a few studies have supporting strong evidences that MAS receptors mediate the effects elicited by AT1 antagonists. The present Perspective provides an overview of the regulatory mechanisms involving AT1 and MAS receptors, their significance to RAS Pharmacology and the future directions on the interplay between angiotensin receptors.
authors.affiliation: School of Pharmaceutical Sciences from Ribeirão Preto (FCFRP), University of São Paulo (USP), Ribeirão Preto, SP, Brazil. Electronic address: l.pernomian@usp.br.
authors.forename: Larissa
authors.initials: L
authors.lastname: Pernomian
authors.affiliation: School of Pharmaceutical Sciences from Ribeirão Preto (FCFRP), University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Laena
authors.initials: L
authors.lastname: Pernomian
authors.affiliation: School of Pharmaceutical Sciences from Ribeirão Preto (FCFRP), University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Mayara S
authors.initials: MS
authors.lastname: Gomes
authors.affiliation: School of Pharmaceutical Sciences from Ribeirão Preto (FCFRP), University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Carlos H T P
authors.initials: CH
authors.lastname: da Silva
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D044140:Receptor, Angiotensin, Type 1; D043562:Receptors, G-Protein-Coupled
keywords: AT(1) receptors; Angiotensin II; Angiotensin-(1-7); Angiotensin-converting enzyme 2; MAS receptors; Renin-angiotensin system