title: Odontoiatric perspectives and osteonecrosis of the jaw as a possible adverse effect of bisphosphonates therapy in fibrous dysplasia and McCune-Albright syndrome.
abstract: BACKGROUND
  McCune-Albright syndrome (MAS) is characterized by the triad of polyostotic bone fibrous dysplasia (PFD), endocrine disorders, and café-au-lait skin pigmentation. Ninety percent of MAS patients have fibrous dysplasia (FD) craniofacial lesions. Osteonecrosis of the jaw (ONJ) has been described as an adverse side effect of bisphosphonate therapy. The aim of the study was to investigate evidence of clinical and/or radiological signs of ONJ in FD/MAS pediatric patients due to bisphosphonate therapy and describe odontoiatric tools in this population.
  
  
  METHODS
  Thirteen FD/MAS patients were enrolled. All patients during pediatric age have been treated with pamidronate infusions. They underwent complete oral clinical examination. Ortopantomography and/or CT were evaluated in all cases.
  
  
  CONCLUSIONS
  No patient developed ONJ. None of them showed radiological signs different from jaw FD. In spite of the low number of patients enrolled, results confirm that, in this population, ONJ can be ruled out as a chronic adverse side effect of bisphosphonate therapy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Tessaris
authors.forename: Patrizia
authors.initials: P
authors.lastname: Matarazzo
authors.forename: Roberto
authors.initials: R
authors.lastname: Lala
authors.forename: Patrizia
authors.initials: P
authors.lastname: Defabianis
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004164:Diphosphonates / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D010020:Osteonecrosis / Q000139:chemically induced* / Q000473:pathology; D011379:Prognosis; D014076:Tooth Diseases / Q000139:chemically induced* / Q000473:pathology; D055815:Young Adult
chemical_list: D004164:Diphosphonates