title: [Brain activitivation of euthymic patients with Type I bipolar disorder in resting state Default Mode Network].
abstract: BACKGROUND
  As there are still doubts about brain connectivity in type I bipolar disorder (BID), resting-state functional magnetic resonance imaging (RS-fMRI) studies are necessary during euthymia for a better control of confounding factors.
  
  
  OBJECTIVE
  To evaluate the differences in brain activation between euthymic BID patients and control subjects using resting state- functional-magnetic resonance imaging (RS-fMRI), and to identify the lithium effect in these activations.
  
  
  METHODS
  A cross-sectional study was conducted on 21 BID patients (10 receiving lithium only, and 11 non-medicated) and 12 healthy control subjects, using RS fMRI and independent component analysis (ICA).
  
  
  RESULTS
  Increased activation was found in the right hippocampus (P=.049) and posterior cingulate (P=.040) within the Default Mode Network (DMN) when BID and control group were compared. No statistically significant differences were identified between BID on lithium only therapy and non-medicated BID patients.
  
  
  CONCLUSIONS
  The results suggest that there are changes in brain activation and connectivity in BID even during euthymic phase and mainly within the DMN network, which could be relevant in affect regulation.
authors.affiliation: Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Cristian
authors.initials: C
authors.lastname: Vargas
authors.affiliation: Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Universidad de Antioquia, Medellín, Colombia; Instituto de Alta Tecnología Médica IATM, Medellín, Colombia.
authors.forename: Julián
authors.initials: J
authors.lastname: Pineda
authors.affiliation: Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Universidad de Antioquia, Medellín, Colombia; Instituto de Alta Tecnología Médica IATM, Medellín, Colombia.
authors.forename: Víctor
authors.initials: V
authors.lastname: Calvo
authors.affiliation: Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Universidad de Antioquia, Medellín, Colombia; Instituto de Alta Tecnología Médica IATM, Medellín, Colombia; Coordinador del Programa de Trastornos del Ánimo, Hospital San Vicente Fundación; Jefe del Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Universidad de Antioquia, Medellín, Colombia. Electronic address: clopez@medicina.udea.edu.co.
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Jaramillo
keywords: Functional MRI fMRI Bipolar disorder Resting State Network Default Mode Network; Imagen por resonancia magnética funcional IRM funcional Trastorno bipolar Conectividad en estado de reposo Default Mode Network