title: Budd-Chiari Syndrome in a patient with Multiple Hypercoagulopathies.
abstract: OBJECTIVE
  To describe a patient with Budd-Chiari syndrome (BCS) found to have multiple hypercoagulopathies.
  
  
  METHODS
  A 33-year-old man who presented with abdominal distension, hematemesis, shortness of breath was found to have liver cirrhosis, portal hypertension and Budd-Chiari Syndrome. He was evaluated for hypercoagulability and was found to be heterozygous for Factor V Leiden mutation and his protein C level was 38% of normal. He was started on oral anticoagulation and underwent elective liver transplantation within 3 months of diagnosis.
  
  
  CONCLUSIONS
  In patients with Budd-Chiari syndrome, factor V Leiden is the second most commonly identified prothrombotic state after primary myeloproliferative disorders. There may be a coexistence of several thrombophilic states in patients with Budd-Chiari Syndrome.
  
  
  CONCLUSIONS
  Budd-Chiari syndrome is an uncommon disorder. Outcome is poor in many cases. Therefore, a successful diagnostic and therapeutic approach is of vital importance. A complete thrombophilia screening needs to be requested in all patients diagnosed with Budd-Chiari syndrome. Thorough investigation needs to be performed to identify an underlying process contributing to the hepatic venous outflow obstruction.
authors.forename: Shashank
authors.initials: S
authors.lastname: Kraleti
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D006502:Budd-Chiari Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D017558:Elective Surgical Procedures / Q000379:methods; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D016031:Liver Transplantation; D008297:Male; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000628:therapy
chemical_list: D000925:Anticoagulants