title: Integrating Personalized Medicine in the Canadian Environment: Efforts Facilitating Oncology Clinical Research.
abstract: There is currently a rapid evolution of clinical practices based on the introduction of patient stratification and molecular diagnosis that is likely to improve health outcomes. Building on a strong research base, complemented by strong support from clinicians and health authorities, the oncology field is at the forefront of this evolution. Yet, clinical research is still facing many challenges that need to be addressed in order to conduct necessary studies and effectively translate medical breakthroughs based on personalized medicine into standards of care. Leveraging its universal health care system and on resources developed to support oncology clinical research, Canada is well positioned to join the international efforts deployed to address these challenges. Available resources include a broad range of structures and funding mechanisms, ranging from direct clinical trial support to post-marketing surveillance. Here, we propose a clinical model for the introduction of innovation for precision medicine in oncology that starts with patients' and clinicians' unmet needs to initiate a cycle of discovery, validation, translation and sustainability development.
authors.affiliation: CIHR Institute of Cancer Research, Calgary, Alta., Canada.
authors.forename: Rachel
authors.initials: R
authors.lastname: Syme
authors.forename: Bruce
authors.initials: B
authors.lastname: Carleton
authors.forename: Lada
authors.initials: L
authors.lastname: Leyens
authors.forename: Etienne
authors.initials: E
authors.lastname: Richer
mesh_terms: D035843:Biomedical Research / Q000191:economics / Q000639:trends*; D002170:Canada; D002986:Clinical Trials as Topic; D003695:Delivery of Health Care; D006801:Humans; D008495:Medical Oncology / Q000191:economics / Q000639:trends*; D057089:Pathology, Molecular; D010372:Pediatrics; D057285:Precision Medicine / Q000191:economics / Q000379:methods* / Q000639:trends*; D011358:Product Surveillance, Postmarketing; D057170:Translational Research, Biomedical / Q000191:economics / Q000639:trends