title: CD14 gene-159C/T polymorphism and coronary artery disease: a meta-analysis involving 4467 subjects.
abstract: BACKGROUND
  The cluster of differentiation antigen 14 (CD14) gene-159C/T polymorphism has been implied to be associated with coronary artery disease (CAD) susceptibility. However, the separate studies results are still conflicting between each other.
  
  
  OBJECTIVE
  To investigate the relationship between CD14 gene-159C/T polymorphism and CAD, a meta-analysis including 4467 subjects from 7 individual studies was performed. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals.
  
  
  RESULTS
  There was a significant association between CD14 gene -159C/T polymorphism and CAD in the whole population under allelic (OR: 1.280, 95% CI: 1.000-1.630, P=0.05), recessive (OR: 1.760, 95% CI: 1.120-2.750, P=0.01), homozygous (OR: 1.693, 95% CI: 1.008-2.843, P=0.046), and additive genetic models (OR: 1.278, 95% CI: 1.000-1.633, P=0.050). No significant association was found between them under dominant (OR: 0.580, 95% CI: 0.310-1.110, P=0.10) and heterozygous genetic models (OR: 1.334, 95% CI: 0.870-2.045, P=0.186). In the subgroup analysis, a significant association was detected in Chinese population (P<0.05), while there was no significant association in the Caucasian subgroup (P>0.05).
  
  
  CONCLUSIONS
  CD14 gene -159C/T polymorphism was significantly associated with CAD susceptibility, particularly in the Chinese population. The person with T allele of CD14 gene -159C/T polymorphism might predispose to CAD. There was no distinct association between them in the Caucasian subgroup.
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing 210029, China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Li
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing 210029, China.
authors.forename: Xiang-Ming
authors.initials: XM
authors.lastname: Wang
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing 210029, China.
authors.forename: Chuan-Wei
authors.initials: CW
authors.lastname: Zhou
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing 210029, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing 210029, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
keywords: -159C/T; CD14; coronary artery disease; polymorphism