title: Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B.
abstract: Central nervous system (CNS) infection with Candida is rare but significant because of its high morbidity and mortality. When present, it is commonly seen among immunocompromised and hospitalized patients. Herein, we describe a case of a four-year-old boy with acute lymphoblastic leukemia (ALL) who experienced recurrent Candida albicans meningitis. The patient was treated successfully with intravenous liposomal amphotericin B at first attack, but 25 days after discharge he was readmitted to hospital with symptoms of meningitis. Candida albicans was grown in CFS culture again and cranial magnetic resonance imaging (MRI) showed ventriculitis. We administered liposomal amphotericin B both intravenously and intraventricularly and favorable result was achieved without any adverse effects. Intraventricular amphotericin B may be considered for the treatment of recurrent CNS Candida infections in addition to intravenous administration.
authors.affiliation: Department of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Toprak
authors.affiliation: Department of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, Turkey.
authors.forename: Sevliya
authors.initials: S
authors.lastname: Öcal Demir
authors.affiliation: Department of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, Turkey.
authors.forename: Eda Kepenekli
authors.initials: EK
authors.lastname: Kadayifci
authors.affiliation: Department of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, Turkey.
authors.forename: Özden
authors.initials: Ö
authors.lastname: Türel
authors.affiliation: Department of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Soysal
authors.affiliation: Department of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Bakir