title: Role of γδ T Cells in Lung Inflammation.
abstract: The resident population of γδ T cells in the normal lung is small but during lung inflammation, γδ T cells can increase dramatically. Histological analysis reveals diverse interactions between γδ T cells and other pulmonary leukocytes. Studies in animal models show that γδ T cells play a role in allergic lung inflammation where they can protect normal lung function, that they also are capable of resolving infection-induced pulmonary inflammation, and that they can help preventing pulmonary fibrosis. Lung inflammation threatens vital lung functions. Protection of the lung tissues and their functions during inflammation is the net-effect of opposing influences of specialized subsets of γδ T cells as well as interactions of these cells with other pulmonary leukocytes.
authors.affiliation: Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 and University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: Willi K
authors.initials: WK
authors.lastname: Born
authors.affiliation: Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 and University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Roark
authors.affiliation: Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 and University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: Niyun
authors.initials: N
authors.lastname: Jin
authors.affiliation: Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 and University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Wands
authors.affiliation: Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 and University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kemal Aydintug
authors.affiliation: Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 and University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 and University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Chain
authors.affiliation: Department of Pediatrics, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 361-711 and 240, Korea.
authors.forename: Youn-Soo
authors.initials: YS
authors.lastname: Hahn
authors.affiliation: Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: Philip L
authors.initials: PL
authors.lastname: Simonian
authors.affiliation: Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Fontenot
authors.affiliation: Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 and University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: O'Brien
keywords: T cells; inflammation; lung