title: Higher Frequency of CD4+CXCR5+ICOS+PD1+ T Follicular Helper Cells in Patients With Infectious Mononucleosis.
abstract: Follicular helper T (Tfh) cells are recognized as a distinct CD4helper T cell subset, and mainly dysregulated in the autoimmune disease, whether it plays a role in the infectious mononucleosis (IM) diseases is unknown. In this study, we found that the CD4CXCR5 Tfh cells were not significantly changed, but the CD4CXCR5ICOS and CD4CXCR5ICOSPD1 Tfh subsets were significantly increased in the IM patients, and all these cells were significantly changed after antiviral therapy. Second, only the numbers of CD4CXCR5ICOSPD1 Tfh cells correlated with the Epstein-Barr virus (EBV) DNA load, negatively correlated with the numbers of naive B cells and amount of IL-21, and positively correlated with the numbers of plasma cells, memory B cells, and atypical lymphocytes. Third, the frequency of CD4CXCR5ICOSPD1 Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase (ALT). All together, our findings discovered this CD4CXCR5ICOSPD1 Tfh cell subset might play an important role in the pathogenesis of IM.
authors.affiliation: From the Department of Clinical Laboratory (JL, YZ, QY, ZZ, HW, ZZ, MW, LQ); Department of Pediatrics (XL, GC); and Department of Rheumatology (YC), Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Jinlin
authors.initials: J
authors.lastname: Liu
authors.forename: Yonglie
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Yu
authors.forename: Zhao
authors.initials: Z
authors.lastname: Zhao
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Luo
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhongliang
authors.initials: Z
authors.lastname: Zhu
authors.forename: Guoqing
authors.initials: G
authors.lastname: Chen
authors.forename: Mao
authors.initials: M
authors.lastname: Wu
authors.forename: Liannv
authors.initials: L
authors.lastname: Qiu
mesh_terms: D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D020031:Epstein-Barr Virus Infections / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D007244:Infectious Mononucleosis / Q000276:immunology*; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*