title: Amphiphilic photosensitive dextran-g-poly(o-nitrobenzyl acrylate) glycopolymers.
abstract: Among all photosensitive monomers reported in the literature, o-nitrobenzyl acrylate (NBA) was selected in this present study. Two strategies were compared to produce azido-terminated poly(o-nitrobenzyl acrylate) (PNBA) using controlled Single Electron Transfer-Living Radical Polymerization (SET-LRP). In a parallel way, dextran (Dex) was modified by the introduction of several alkynyl-terminated hydrophobic chains. Finally, an Huisgen-type Copper (I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) click-chemistry was carried out to produce amphiphilic Dex-g-PNBA glycopolymers with different number and length of PNBA grafts. 2D DOSY (1)H NMR was used to prove the formation of such glycopolymers. Preliminary study on Dex-g-PNBA self-assembly was done by measuring the critical water content (CWC) above which Dex-g-PNBA started to auto-organize themselves to produce nano-objects. Finally, under UV irradiation, PNBA grafts turn into poly(acrylic acid) ones giving light-sensitive properties to such amphiphilic Dex-g-PNBA. Such properties were evaluated and compared with those of PNBA.
authors.affiliation: Université de Lorraine, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France; CNRS, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France.
authors.forename: Soliman Mehawed Abdellatif
authors.initials: SM
authors.lastname: Soliman
authors.affiliation: Université de Lorraine, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France; CNRS, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Colombeau
authors.affiliation: Université de Lorraine, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France; CNRS, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Nouvel
authors.affiliation: Université de Lorraine, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France; CNRS, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Babin
authors.affiliation: Université de Lorraine, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France; CNRS, Laboratoire de Chimie Physique Macromoléculaire LCPM, UMR 7375, Nancy F-54000, France. Electronic address: jean-luc.six@univ-lorraine.fr.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Six
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D057930:Click Chemistry; D003911:Dextrans / Q000737:chemistry*; D009578:Nitrobenzenes / Q000737:chemistry; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000179:Acrylates; D003911:Dextrans; D009578:Nitrobenzenes; D017319:Photosensitizing Agents; D013501:Surface-Active Agents
keywords: 2-Nitrobenzyl acrylate; Biodegradable; CRP; Grafted copolymer; Photo-responsive polymer; RDRP