title: Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid.
abstract: We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin, and the hydroxyl group of serine can actively interact with water molecules. Therefore, we hypothesized that serine efficiently delivered to the stratum corneum (SC) of the skin would enhance the moisturizing capability of the skin. We prepared four different cosmeceutical bases (hydrogel, oil-in-water (O/W) essence, O/W cream, and water-in-oil (W/O) cream); their moisturizing abilities were then assessed using a Corneometer®. The hydrogel was selected as the optimum base for skin moisturization based on the area under the moisture content change-time curves (AUMCC) values used as a parameter for the water hold capacity of the skin. Liposomal serine prepared by a reverse-phase evaporation method was then incorporated in the hydrogel. The liposomal serine-incorporated hydrogel (serine level=1%) showed an approximately 1.62~1.77 times greater moisturizing effect on the skin than those of hydrogel, hydrogel with serine (1%), and hydrogel with blank liposome. However, the AUMCC values were not dependent on the level of serine in liposomal serine-loaded hydrogels. Together, the delivery of serine to the SC of the skin is a promising strategy for moisturizing the skin. This study is expected to be an important step in developing highly effective moisturizing cosmeceutical products.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Hyeongmin
authors.initials: H
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Jieun
authors.initials: J
authors.lastname: Ro
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Sonia
authors.initials: S
authors.lastname: Barua
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Deuk Sun
authors.initials: DS
authors.lastname: Hwang
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Seon-Jeong
authors.initials: SJ
authors.lastname: Na
authors.affiliation: College of Medicine, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Lee
authors.affiliation: College of Medicine, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Pharmaceutical Industry Management, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Seulki
authors.initials: S
authors.lastname: Woo
authors.affiliation: Department of Pharmaceutical Industry Management, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Hyewon
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Pharmaceutical Industry Management, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Bomi
authors.initials: B
authors.lastname: Hong
authors.affiliation: Department of Food Science and Technology, Chung-Ang University, Anseong 17546, Korea.
authors.forename: Gyiae
authors.initials: G
authors.lastname: Yun
authors.affiliation: Erom Co., Ltd., Chuncheon 24441, Korea.
authors.forename: Joong-Hark
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Erom Co., Ltd., Chuncheon 24441, Korea.
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Yoon
authors.affiliation: Erom Co., Ltd., Chuncheon 24441, Korea.
authors.forename: Myung-Gyu
authors.initials: MG
authors.lastname: Park
authors.affiliation: Graduate School of Food and Drug Administration, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Jia
authors.initials: J
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Uy Dong
authors.initials: UD
authors.lastname: Sohn
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
authors.forename: Jaehwi
authors.initials: J
authors.lastname: Lee
keywords: Corneometer; Hydrogel; Liposome; Serine; Skin moisturization