title: 1,8-Naphthyridine Derivatives: A Review of Multiple Biological Activities.
abstract: The 1,8-naphthyridine group of compounds have gained special attention of researchers on account of their demonstrating a variety of interesting biological activities. A wide range of biological properties establishes them as potent scaffolds in therapeutic and medicinal research. The broad spectrum of activities primarily includes antimicrobial, antiviral, anticancer, anti-inflammatory, and analgesic activities. 1,8-Naphthyridine derivatives have also exhibited potential applications in neurological disorders such as Alzheimer's disease, multiple sclerosis, and depression. In addition, these synthetic derivatives have been found to possess activities such as anti-osteoporotic (α(v)β(3) antagonists), anti-allergic, antimalarial, gastric antisecretory, bronchodilator, anticonvulsant, anti-hypertensive, platelet aggregation inhibition, anti-oxidant, EGFR inhibition, protein kinase inhibition, ionotropic agent, β-3 antagonist, MDR modulator, adenosine receptor agonist, adrenoceptor antagonist, and pesticide activities. In spite of the widespread application of the 1,8-naphythyridine scaffolds, only a limited number of review articles are available till date. In this review, we attempt to compile and discuss the key data available in the literature for the multiple biological activities of 1,8-naphthyridine derivatives, in a chronological manner. This review compilation (with 199 references) may be helpful in understanding the diverse biological properties of 1,8-naphthyridines and provide insights into their mechanism of action. This may direct future research in the synthesis of new derivatives and exploring this scaffold for other possible biological activities.
authors.affiliation: Cell Biology Lab, Dabur Research Foundation, Sahibabad, Ghaziabad, Uttar Pradesh, India.
authors.forename: Alka
authors.initials: A
authors.lastname: Madaan
authors.affiliation: Cell Biology Lab, Dabur Research Foundation, Sahibabad, Ghaziabad, Uttar Pradesh, India.
authors.forename: Ritu
authors.initials: R
authors.lastname: Verma
authors.affiliation: Chemical Research Lab, Dabur Research Foundation, Sahibabad, Ghaziabad, Uttar Pradesh, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Kumar
authors.affiliation: Cell Biology Lab, Dabur Research Foundation, Sahibabad, Ghaziabad, Uttar Pradesh, India.
authors.forename: Anu T
authors.initials: AT
authors.lastname: Singh
authors.affiliation: Department of Medical Biochemistry, HIMSR and Department of Biotechnology, Jamia Hamdard, New Delhi, India.
authors.forename: Swatantra K
authors.initials: SK
authors.lastname: Jain
authors.affiliation: Cell Biology Lab, Dabur Research Foundation, Sahibabad, Ghaziabad, Uttar Pradesh, India.
authors.forename: Manu
authors.initials: M
authors.lastname: Jaggi
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002491:Central Nervous System Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009287:Naphthyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D002491:Central Nervous System Agents; D009287:Naphthyridines
keywords: 1,8-Napthyridine; Anti-inflammatory; Antibacterial; Anticancer; Neurological