title: Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models.
abstract: Among the most promising approaches for treating Alzheimer's disease is immunotherapy with amyloid-β (Aβ)-targeting antibodies. Using in vivo two-photon imaging in mouse models, we found that two different antibodies to Aβ used for treatment were ineffective at repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This unexpected finding provides a possible cellular explanation for the lack of cognitive improvement by immunotherapy in human studies.
authors.affiliation: Institute of Neuroscience, Technische Universität München, Munich, Germany.|Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.|Munich Cluster for Systems Neurology (SyNergy), München, Germany.
authors.forename: Marc Aurel
authors.initials: MA
authors.lastname: Busche
authors.affiliation: Institute of Neuroscience, Technische Universität München, Munich, Germany.|Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Grienberger
authors.affiliation: Institute of Neuroscience, Technische Universität München, Munich, Germany.
authors.forename: Aylin D
authors.initials: AD
authors.lastname: Keskin
authors.affiliation: Institute of Neuroscience, Technische Universität München, Munich, Germany.
authors.forename: Beomjong
authors.initials: B
authors.lastname: Song
authors.affiliation: Novartis Institute for BioMedical Research, Basel, Switzerland.
authors.forename: Ulf
authors.initials: U
authors.lastname: Neumann
authors.affiliation: Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Staufenbiel
authors.affiliation: Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.
authors.forename: Hans
authors.initials: H
authors.lastname: Förstl
authors.affiliation: Institute of Neuroscience, Technische Universität München, Munich, Germany.|Munich Cluster for Systems Neurology (SyNergy), München, Germany.
authors.forename: Arthur
authors.initials: A
authors.lastname: Konnerth
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology* / Q000378:metabolism / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000276:immunology* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides