title: Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system.
abstract: In past decades, growing evidence from basic and clinical researches reveal that small guanosine triphosphate binding protein ras homolog gene family, member A (RhoA) and its main effector Rho-associated kinase (ROCK) play central and complex roles in cardiovascular systems, and increasing RhoA and ROCK activity is associated with a broad range of cardiovascular diseases such as congestive heart failure, atherosclerosis, and hypertension. Favorable outcomes have been observed with ROCK inhibitors treatment. In this review, we briefly summarize the pathophysiological roles of RhoA/ROCK signaling pathway on cardiovascular system, displaying the potential benefits in the cardiovascular system with controlling RhoA/ROCK signaling pathway.
authors.affiliation: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China *Anping Cai and Liwen Li contributed equally to the writing of this article.
authors.forename: Anping
authors.initials: A
authors.lastname: Cai
authors.forename: Liwen
authors.initials: L
authors.lastname: Li
authors.forename: Yingling
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000503:physiopathology; D002319:Cardiovascular System / Q000196:embryology / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D054460:rho-Associated Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D054460:rho-Associated Kinases; D020742:rhoA GTP-Binding Protein