title: [Changes in neuropeptide Y and substance P immunoreactive nerve fibres and immunocompetent cells in hepatitis].
abstract: Neuropeptide Y and substance P were thought to play a role in the function of immune cells and in amplification or elimination of the inflammatory processes. In hepatitis the number of both neuropeptide Y and substance P immunoreactive nerve fibres are increased, where the increase of neoropeptide Y is significant. A large number of lymphocytes and mast cells are also stained for neuropeptide Y and substance P. Very close associations (less than 1 µm) were observed between neuropeptide Y immunoreactive nerve fibres and immune cells stained also with neuropeptide Y. Some immune cells were also found to be immunoreactive for tumor necrosis factor-α and NF-κB. Some of the SP IR immunocells were also stained for TNF-α and nuclear factor kappaB. Based on these data it is hypothesized that neuropeptid Y and substance P released from nerve fibres and immune cells play a role in inflammation and elimination of inflammation in hepatitis.
authors.affiliation: Anatómiai, Szövet- és Fejlődéstani Intézet, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Tűzoltó u. 58., 1094.
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Fehér
mesh_terms: D006505:Hepatitis / Q000276:immunology*; D006801:Humans; D007121:Immunocompetence; D007150:Immunohistochemistry; D007694:Killer Cells, Natural / Q000276:immunology; D052002:NF-kappa B p50 Subunit / Q000276:immunology; D009478:Neuropeptide Y / Q000276:immunology*; D013373:Substance P / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D009478:Neuropeptide Y; D014409:Tumor Necrosis Factor-alpha; D013373:Substance P
keywords: P anyag; hepatitis; neuroimmun-moduláció; neuroimmune modulation; neuropeptid Y; neuropeptide Y; substance P