title: A universal tumor cell isolation method enabled by fibrin-coated microchannels.
abstract: We report a simple but effective strategy to capture tumor cells using fibrin-immobilized microchannels. It is a universal method since it shows an ability to capture both epithelial and mesenchymal tumor cells. The cell capture efficiency is up to 90%.
authors.affiliation: Interdisciplinary Microsystems Group, Department of Mechanical and Aerospace Engineering, University of Florida, PO Box 116250, Gainesville, Florida 32611, USA. hfan@ufl.edu.
authors.forename: Jinling
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Interdisciplinary Microsystems Group, Department of Mechanical and Aerospace Engineering, University of Florida, PO Box 116250, Gainesville, Florida 32611, USA. hfan@ufl.edu and J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, P.O. Box 116131, Gainesville, FL 32611, USA.
authors.forename: Z Hugh
authors.initials: ZH
authors.lastname: Fan
mesh_terms: D045744:Cell Line, Tumor; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods*; D005337:Fibrin / Q000737:chemistry*; D006801:Humans; D056656:Lab-On-A-Chip Devices; D009360:Neoplastic Cells, Circulating / Q000737:chemistry / Q000473:pathology
chemical_list: D005337:Fibrin