title: Multifocal ERG Guiding Therapy in a Case of Hydroxychloroquine Premaculopathy.
abstract: We report the case of a 28-year-old female treated for systemic lupus erythematosus with hydroxychloroquine (200 mg/day) for 11 years. She was visually asymptomatic, with normal fundus appearance, normal colour vision testing findings, 20/20 visual acuity in both eyes, and only mild central bilateral defects on 10-2 perimetry. Multifocal electroretinography (mfERG) showed low density values for ring 1 in both eyes. Because the patient had not previously responded to alternative treatments and in consultation with her physician, the hydroxychloroquine dose was reduced to 200 mg four days/week. Four serial mfERGs performed at 4, 18, 25, and 34 months after dose reduction showed a progressive improvement in the definition and density of the responses until they were normalized at the third mfERG (25 months after hydroxychloroquine dose reduction). The fourth and final mfERG at 34 months confirmed the recovery in both eyes. Perimetry defects were mostly normalized. These results demonstrate the importance of mfERG for the safe management of patients under long-term hydroxychloroquine treatment.
authors.affiliation: Laboratory of Visual and Cognitive Neuroscience, Institute of Neuroscience, Granada University, 18100 Granada, Spain ; Department of Clinical Electrophysiology, San Cecilio University Hospital, 18100 Granada, Spain.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Sáez-Moreno
authors.affiliation: Laboratory of Visual and Cognitive Neuroscience, Institute of Neuroscience, Granada University, 18100 Granada, Spain ; Department of Ophthalmology, San Cecilio University Hospital, 18100 Granada, Spain.
authors.forename: Concepción
authors.initials: C
authors.lastname: Domínguez-Hidalgo
authors.affiliation: Laboratory of Visual and Cognitive Neuroscience, Institute of Neuroscience, Granada University, 18100 Granada, Spain ; Department of Physiology, School of Medicine, Granada University, 18100 Granada, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez-Ferrer