title: Mitochondria-targeted drug delivery system for cancer treatment.
abstract: Mitochondria are one type of the major organelles in the cell, participating in a variety of important physiological and biochemical processes, such as tricarboxylic acid cycle, fatty acid metabolism and oxidative phosphorylation. Meanwhile, it also happens to be the key regulator of apoptosis by triggering the complex cell-death processes through a variety of mechanisms. Since it plays a pivotal role in cell-death, a mitochondria-targeted treatment strategy could be promising for cancer therapy. In this comprehensive review, we focused on the mechanisms of mitochondrial targeting and a variety of strategies to realize the purpose of mitochondrial targeting, including that based on the use of lipophilic cations, and mitochondrial targeting signal peptides (MTS) as well as cell-penetrating peptides (CPPs). Then on this basis we present some several developed strategies for multifunctional mitochondria-targeted agents so as to achieve the good anti-cancer therapeutic effects.
authors.affiliation: a Department of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China and.
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Chen
authors.affiliation: a Department of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China and.
authors.forename: Man
authors.initials: M
authors.lastname: Li
authors.affiliation: a Department of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China and.
authors.forename: Liu-Jie
authors.initials: LJ
authors.lastname: Zhang
authors.affiliation: a Department of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China and.
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: He
authors.affiliation: a Department of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China and.
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.affiliation: b Department of Pharmacy , China Pharmaceutical University , Nanjing , P.R. China.
authors.forename: Yan-Yu
authors.initials: YY
authors.lastname: Xiao
authors.affiliation: a Department of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China and.
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
authors.affiliation: b Department of Pharmacy , China Pharmaceutical University , Nanjing , P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Cai
authors.affiliation: a Department of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China and.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects; D057846:Cell-Penetrating Peptides / Q000378:metabolism; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D057846:Cell-Penetrating Peptides
keywords: Mitochondria-targeted; multifunctional; multilevel targeting; nanomedicine; peptides