title: Consequences of Circadian Disruption on Cardiometabolic Health.
abstract: Cardiovascular disease, diabetes and obesity are highly prevalent diseases associated with reduced quality of life and life expectancy. We discuss a novel risk factor for these cardiometabolic diseases: circadian disruption. Circadian disruption occurs when the internal circadian (∼24-hour) rhythms are not in synchrony with the environment or each other. This paper reviews (1) cardiometabolic health of shift work, which often leads to circadian disruption, (2) effects of experimentally disrupted circadian rhythms on cardiometabolic function, (3) observational studies of sleep timing and behavioral chronotype, and (4) potential mediators linking chronotype and shift work to circadian disruption and cardiometabolic health.
authors.affiliation: Division of Endocrinology and Metabolism, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok 10400, Thailand.
authors.forename: Sirimon
authors.initials: S
authors.lastname: Reutrakul
authors.affiliation: Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 6076, Chicago, IL 60637, USA. Electronic address: kknutson@medicine.bsd.uchicago.edu.
authors.forename: Kristen L
authors.initials: KL
authors.lastname: Knutson
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans
keywords: Cardiovascular disease; Circadian rhythms; Diabetes; Shift work