title: Targeting IL-17 with ixekizumab in patients with psoriasis.
abstract: Psoriasis is a multifactorial chronic inflammatory skin disease of unknown etiology. Knowledge of the pathophysiology of psoriasis has evolved and identified IL-17 as a key pro-inflammatory mediator in psoriasis creating new medical avenues. Several agents targeting IL-17 or its receptor are in clinical trials for the treatment of moderate-to-severe psoriasis. This review focuses on the biological rationale and the results of clinical trials with ixekizumab, a humanized IgG4 monoclonal antibody. The currently available Phase I to III data indicate that ixekizumab is a well-tolerated promising drug, although long-term data of efficacy and safety are needed before ixekizumab and other IL-17 targeting therapeutics can find their place in clinical practice.
authors.affiliation: Department of Dermato-Allergology, Herlev & Gentofte Hospital, Kildegaardsvej 28, DK-2900 Hellerup, Denmark.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Dyring-Andersen
authors.affiliation: Department of Dermato-Allergology, Herlev & Gentofte Hospital, Kildegaardsvej 28, DK-2900 Hellerup, Denmark.
authors.forename: Lone
authors.initials: L
authors.lastname: Skov
authors.affiliation: Department of Dermato-Allergology, Herlev & Gentofte Hospital, Kildegaardsvej 28, DK-2900 Hellerup, Denmark.
authors.forename: Claus
authors.initials: C
authors.lastname: Zachariae
mesh_terms: D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D020381:Interleukin-17 / Q000378:metabolism*; D015603:Keratinocytes / Q000187:drug effects* / Q000276:immunology; D058990:Molecular Targeted Therapy; D011565:Psoriasis / Q000276:immunology / Q000628:therapy*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D020381:Interleukin-17; C549079:ixekizumab
keywords: IL-17A; IL-17F; IL-22; ixekizumab; psoriasis