title: Phosphorylcholine-Based Zwitterionic Biocompatible Thermogel.
abstract: Zwitterionic polymers have been investigated as surface-coating materials due to their low protein adsorption properties, which reduce immunogenicity, biofouling, and bacterial adsorption of coated materials. Most zwitterionic polymers, reported so far, are based on (meth)acrylate polymers which can induce toxicity by residual monomers or amines produced by degradation. Here, we report a new zwitterionic polymer consisting of phosphorylcholine (PC) and biocompatible poly(propylene glycol) (PPG) as a new thermogelling material. The PC-PPG-PC polymer aqueous solution undergoes unique multiple sol-gel transitions as the temperature increases. A heat-induced unimer-to-micelle transition, changes in ionic interactions, and dehydration of PPG are involved in the sol-gel transitions. Based on the broad gel window and low protein adsorption properties, the PC-PPG-PC thermogel is proved for sustained delivery of protein drugs and stem cells over 1 week.
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea.
authors.forename: Du Young
authors.initials: du Y
authors.lastname: Ko
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea.
authors.forename: Madhumita
authors.initials: M
authors.lastname: Patel
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea.
authors.forename: Bo Kyoeng
authors.initials: BK
authors.lastname: Jung
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea.
authors.forename: Jin Hye
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Chemistry and Nanoscience, Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea.
authors.forename: Byeongmoon
authors.initials: B
authors.lastname: Jeong
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002648:Child; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D004339:Drug Compounding / Q000379:methods; D065546:Drug Liberation; D005260:Female; D005782:Gels; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D007328:Insulin / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects; D014066:Palatine Tonsil / Q000166:cytology / Q000187:drug effects; D044367:Phase Transition; D010767:Phosphorylcholine / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D061251:Primary Cell Culture; D011409:Propylene Glycols / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013696:Temperature
chemical_list: D000179:Acrylates; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D005782:Gels; D007004:Hypoglycemic Agents; D007328:Insulin; D011108:Polymers; D011409:Propylene Glycols; D010767:Phosphorylcholine; C012504:polypropylene glycol; C036658:acrylic acid