title: Retinol Binding Protein-4 and Adiponectin Levels in Thyroid Overt and Subclinical Dysfunction.
abstract: Thyroid dysfunction is accompanied by numerous changes in intermediary metabolism. Retinol binding protein-4 (RBP-4) and adiponectin are 2 adipocytokines that have multiple metabolic functions. The aim of our study was to examine serum RBP4 and adiponectin levels in clinical (before and after therapy) and subclinical hyperthyroid and hypothyroid subjects as compared to controls.150 patients with thyroid dysfunction were recruited (65 hyperthyroid and 85 hypothyroid) while 28 euthyroid subjects served as a control group. We measured anthropometric, biochemical and hormonal (free T4, free T3, TSH, insulin) parameters in all participants. RBP-4 and adiponectin were measured using commercial ELISA kits.Mean baseline levels of RBP-4 were higher in patients with clinical hypothyroidism (29.0±10.2 ng/ml, 25.1±12.6 ng/ml, 38.8±16.5 ng/ml, 31.9±13.2 ng/ml, 20.4±8.2 ng/ml in patients with hyperthyroidism, subclinical hyperthryrodism, hypothyroidism, subclinical hypothyroidism and controls respectively, F=4.86, P<0.001) and decreased significantly in patients with clinical hyperthyroidism and hypothyroidism after normalization of thyroid hormones' levels (from 29.0±10.2 to 24.9±8.4 ng/ml, p=0.003 and from 38.8±16.5 to 29.0±10.8 ng/ml, p=0.001 respectively). We did not observe analogous changes in adiponectin levels in any of the studied groups.RBP-4 levels are higher in patients with clinical hypothyroidism and exhibit a marked decrease after normalization of thyroid function in both hyper and hypothyroid patients. We suggest that RBP-4 may play a role in the metabolic disturbances which accompany thyroid dysfunction.
authors.affiliation: Second Department of Internal Medicine, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Kokkinos
authors.affiliation: Second Department of Internal Medicine, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Papazoglou
authors.affiliation: Laboratory of Nuclear Medicine, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Zisimopoulos
authors.affiliation: Second Department of Internal Medicine, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Papanas
authors.affiliation: Second Department of Internal Medicine, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Tiaka
authors.affiliation: Second Department of Internal Medicine, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Antonoglou
authors.affiliation: Second Department of Internal Medicine, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Maltezos
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D007037:Hypothyroidism / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma