title: Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits.
abstract: OBJECTIVE
  To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH).
  
  
  METHODS
  The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S1P phosphatase expression were measured at day 3, 5, 7, 9.
  
  
  RESULTS
  The expression of S1P was enhanced in the cerebral vasospasm after subarachnoid hemorrhage in the rabbits. And S1P expression was consistent with the basilar artery cross-sectional area changes at day 3, 5, 7, 9.
  
  
  CONCLUSIONS
  Sphingosine-1-phosphate expression in the cerebral arterial may be a new indicator in the development of cerebral vasospasm after subarachnoid hemorrhage and provide a new therapeutic method for SAH.
authors.affiliation: Department of Neurosurgery, Wuhan University, Hubei Province, P.R.C, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Neurosurgery, Renmin Hospital, Three Gorges University, Hubei Province, P.R.C., China.
authors.forename: Donggang
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Renmin Hospital, Three Gorges University, Hubei Province, P.R.C., China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Renmin Hospital, Three Gorges University, Hubei Province, P.R.C., China.
authors.forename: Ming
authors.initials: M
authors.lastname: Fang
authors.affiliation: Department of Neurosurgery, Renmin Hospital, Three Gorges University, Hubei Province, P.R.C., China.
authors.forename: Feifan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Renmin Hospital, Three Gorges University, Hubei Province, P.R.C., China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Neurosurgery, Renmin Hospital, Three Gorges University, Hubei Province, P.R.C., China.
authors.forename: Na
authors.initials: N
authors.lastname: Tang
authors.affiliation: Department of Neurosurgery, Renmin Hospital, Three Gorges University, Hubei Province, P.R.C., China.
authors.forename: Qianxue
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000473:pathology; D004195:Disease Models, Animal; D005434:Flow Cytometry; D008246:Lysophospholipids / Q000032:analysis*; D011817:Rabbits; D011897:Random Allocation; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000032:analysis; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors; D020301:Vasospasm, Intracranial / Q000209:etiology / Q000378:metabolism / Q000473:pathology*
chemical_list: D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine