title: [Cerebral Changes in the Morphometrics of HIV Patients].
abstract: Cerebral atrophy is a common finding in patients infected with the Human Immunodeficiency Virus (HIV), particularly in patients with dementia. This disease shows neocortical compromise in late stages as well as compromise in the basal ganglia in early or asyntomatic phases.
  
  
  OBJECTIVE
  Evaluate changes in total brain volume, caudate nucleus volume, nucleus accumbens volume, and fractional anisotropy of white matter tracts in HIV patients without neurodegenerative symptoms, in comparison with healthy subjects.
  
  
  METHODS
  For segmentation and quantification purposes of the brain tissue, the brain and skull were extracted and the tissue was normalized according to total brain volume. From the tissue thus obtained, the caudate nucleus and nucleus accumbens volumes were segmented. The method of statistic spatial tractography was used for quantification and search of differences in the fractional anisotropy coefficient.
  
  
  RESULTS
  The percentage of white matter volume with respect to brain volume was smaller in HIV patients (42.83±2.65 %) when compared with healthy subjects (43.56±1.60 %). The percentage of left nucleus accumbens volume in HIV patients was 0.0254±0.0073 % of the brain and 0.0351±0.0067 % in healthy subjects; (p<0.05).
  
  
  CONCLUSIONS
  It was not evident A decrease in the volume of the gray matter parenchyma was not evident or significant, except in the left nucleus accumbens. Global but not regional changes were found in white matter tracts.
authors.affiliation: Director científico del Instituto de Alta Tecnología Médica, Medellín, Colombia. Electronic address: investigacion@iatm.com.co.
authors.forename: Jorge Andrés Delgado
authors.initials: JA
authors.lastname: de Bedout
authors.affiliation: Bioingeniero, grupo de investigación del Instituto de Alta Tecnología Médica, Medellín, Colombia.
authors.forename: Juán Gabriel
authors.initials: JG
authors.lastname: Castrillón
authors.affiliation: Coordinador del grupo de investigación del Instituto de Alta Tecnología Médica, Medellín, Colombia.
authors.forename: Simón
authors.initials: S
authors.lastname: Rascovsky
authors.affiliation: Residente de Radiología, Universidad CES, Medellín, Colombia.
authors.forename: Lina María
authors.initials: LM
authors.lastname: García
authors.affiliation: Médico radiólogo, grupo de investigación del Instituto de Alta Tecnología Médica, Medellín, Colombia.
authors.forename: Jorge Mario
authors.initials: JM
authors.lastname: Vélez
authors.affiliation: Asesor estadístico, grupo de investigación del Instituto de Alta Tecnología Médica, Medellín, Colombia.
authors.forename: Víctor Daniel
authors.initials: VD
authors.lastname: Calvo
keywords: Brain morphometry; HIV; MRI; Morfometría cerebral; VIH; anisotropía fraccional; fractional anisotropy; resonancia magnética