title: Selective Ruthenium-Catalyzed Reductive Alkoxylation and Amination of Cyclic Imides.
abstract: Reported herein, for the first time, is the selective ruthenium-catalyzed reductive alkoxylation and amination of phthalimides/succinimides. Notably, this novel methodology avoids hydrogenation of the aromatic ring and allows methoxylation of substituted imides with good to excellent selectivity for one of the carbonyl groups. The reported method opens the door to the development of new processes for the selective synthesis of various functionalized N-heterocyclic compounds. As an example, intramolecular reductive couplings to afford tricyclic compounds are presented for the first time.
authors.affiliation: Leibniz-Institut für Katalyse e.V., Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
authors.forename: Jose R
authors.initials: JR
authors.lastname: Cabrero-Antonino
authors.affiliation: Leibniz-Institut für Katalyse e.V., Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
authors.forename: Iván
authors.initials: I
authors.lastname: Sorribes
authors.affiliation: Leibniz-Institut für Katalyse e.V., Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
authors.forename: Kathrin
authors.initials: K
authors.lastname: Junge
authors.affiliation: Leibniz-Institut für Katalyse e.V., Albert-Einstein-Str. 29a, 18059 Rostock (Germany). matthias.beller@catalysis.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
keywords: heterocycles; homogeneous catalysis; reduction reactions; ruthenium; synthetic methods