title: The Transporter Classification Database (TCDB): recent advances.
abstract: The Transporter Classification Database (TCDB; http://www.tcdb.org) is a freely accessible reference database for transport protein research, which provides structural, functional, mechanistic, evolutionary and disease/medical information about transporters from organisms of all types. TCDB is the only transport protein classification database adopted by the International Union of Biochemistry and Molecular Biology (IUBMB). It consists of more than 10,000 non-redundant transport systems with more than 11 000 reference citations, classified into over 1000 transporter families. Transporters in TCDB can be single or multi-component systems, categorized in a functional/phylogenetic hierarchical system of classes, subclasses, families, subfamilies and transport systems. TCDB also includes updated software designed to analyze the distinctive features of transport proteins, extending its usefulness. Here we present a comprehensive update of the database contents and features and summarize recent discoveries recorded in TCDB.
authors.affiliation: Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA msaier@ucsd.edu.
authors.forename: Milton H
authors.initials: MH
authors.lastname: Saier
authors.affiliation: Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA Department of Medical Sciences, Boston University School of Medicine, 72 E Concord St., Boston, MA 02118, USA.
authors.forename: Vamsee S
authors.initials: VS
authors.lastname: Reddy
authors.affiliation: Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA.
authors.forename: Brian V
authors.initials: BV
authors.lastname: Tsu
authors.affiliation: Department of Biological Engineering, School of Life Sciences, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
authors.forename: Muhammad Saad
authors.initials: MS
authors.lastname: Ahmed
authors.affiliation: Department of Biological Engineering, School of Life Sciences, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA Department of Biology, Wilfrid Laurier University, 75 University Ave W, Waterloo, ON, Canada N2L 3C5.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Moreno-Hagelsieb
mesh_terms: D030562:Databases, Protein; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000145:classification* / Q000378:metabolism; D020539:Sequence Analysis, Protein
chemical_list: D026901:Membrane Transport Proteins