title: Chemical Constituents from the Fruiting Bodies of Hexagonia apiaria and Their Anti-inflammatory Activity.
abstract: A chemical investigation of the fruiting bodies of Hexagonia apiaria resulted in the identification of nine compounds including five new triterpenoids, hexagonins A-E (1-5), along with four known compounds. The purified constituents were examined for their anti-inflammatory activity. Among the tested compounds, hexatenuin A displayed the most significant inhibition of superoxide anion generation and elastase release. These triterpenoids may have potentials as anti-inflammatory agents.
authors.affiliation: Department of Chemistry, Vinh University , Vinh City 42000, Vietnam.
authors.forename: Tran Dinh
authors.initials: TD
authors.lastname: Thang
authors.affiliation: Department of Biotechnology, National Formosa University , Yunlin 63201, Taiwan, ROC.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.affiliation: Department of Chemistry, Vinh University , Vinh City 42000, Vietnam.
authors.forename: Nguyen Thi Bich
authors.initials: NT
authors.lastname: Ngoc
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University , Taoyuan 33302, Taiwan, ROC.|Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University , Taoyuan 33302, Taiwan, ROC.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Department of Biotechnology, National Formosa University , Yunlin 63201, Taiwan, ROC.
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Yang
authors.affiliation: Neurosurgical Service, Department of Surgery, National Cheng Kung Medical Center and Medical School , Tainan, Taiwan, ROC.
authors.forename: Shih-Huang
authors.initials: SH
authors.lastname: Ta
authors.affiliation: Neurosurgical Service, Department of Surgery, National Cheng Kung Medical Center and Medical School , Tainan, Taiwan, ROC.
authors.forename: E-Jian
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University , Pingtung 90741, Taiwan, ROC.
authors.forename: Dai-Huang
authors.initials: DH
authors.lastname: Kuo
authors.affiliation: Department of Chemistry, Vinh University , Vinh City 42000, Vietnam.
authors.forename: Nguyen Huy
authors.initials: NH
authors.lastname: Hung
authors.affiliation: Department of Chemistry, Vinh University , Vinh City 42000, Vietnam.
authors.forename: Nguyen Ngoc
authors.initials: NN
authors.lastname: Tuan
authors.affiliation: Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University , Pingtung 90741, Taiwan, ROC.|School of Pharmacy, National Cheng Kung University , Tainan 70101, Taiwan, ROC.
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010196:Pancreatic Elastase / Q000187:drug effects / Q000378:metabolism; D011124:Polyporaceae / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism; D014315:Triterpenes / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D014315:Triterpenes; C000605744:hexagonin A; D013481:Superoxides; D010196:Pancreatic Elastase