title: Dimeric Octaketide Spiroketals from the Jellyfish-Derived Fungus Paecilomyces variotii J08NF-1.
abstract: Paeciloketals (1-3), new benzannulated spiroketal derivatives, were isolated from the marine fungus Paecilomyces variotii derived from the giant jellyfish Nemopilema nomurai. Compound 1 was present as a racemate and was resolved into enantiopure 1a and 1b by chiral-phase separation on a cellulose column. Compounds 2 and 3, possessing a novel benzannulated spiroketal skeleton, were rapidly interconvertible and yielded an equilibrium mixture on standing at room temperature. The relative and absolute configurations of compounds 2 and 3 were determined by NOESY analysis and ECD calculations. Compound 1 showed modest antibacterial activity against the marine pathogen Vibrio ichthyoenteri.
authors.affiliation: College of Pharmacy, Pusan National University , Busan 609-735, Korea.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Kyung Hee University , Seoul 130-701, Korea.
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.affiliation: College of Pharmacy, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: College of Pharmacy, Pusan National University , Busan 609-735, Korea.
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301, People's Republic of China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, People's Republic of China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
authors.affiliation: College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
authors.affiliation: College of Pharmacy, Pusan National University , Busan 609-735, Korea.
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005663:Furans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010143:Paecilomyces / Q000737:chemistry*; D037401:Scyphozoa / Q000382:microbiology*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005663:Furans; D013141:Spiro Compounds; C000605719:paeciloketal 1; C000605721:paeciloketal 2; C000605720:paeciloketal 3; C520774:spiroketal