title: Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.
abstract: BACKGROUND
  Evidence regarding the different treatment options of status epilepticus (SE) in adults is scarce. Large randomized trials cover only one treatment at early stage and suggest the superiority of benzodiazepines over placebo, of intravenous lorazepam over intravenous diazepam or over intravenous phenytoin alone, and of intramuscular midazolam over intravenous lorazepam. However, many patients will not be treated successfully with the first treatment step. A large randomized trial covering the treatment of established status (ESETT) has just been funded recently by the NIH and will not start before 2015, with expected results in 2018; a trial on the treatment of refractory status with general anesthetics was terminated early due to insufficient recruitment. Therefore, a prospective multicenter observational registry was set up; this may help in clinical decision-making until results from randomized trials are available.
  
  
  METHODS
  SENSE is a prospective, multicenter registry for patients treated for SE. The primary objective is to document patient characteristics, treatment modalities and in-house outcome of consecutive adults admitted for SE treatment in each of the participating centres and to identify predictors of outcome. Pre-treatment, treatment-related and outcome variables are documented systematically. To allow for meaningful multivariate analysis in the patient subgroups with refractory SE, a cohort size of 1000 patients is targeted.
  
  
  CONCLUSIONS
  The results of the study will provide information about risks and benefits of specific treatment steps in different patient groups with SE at different points of time. Thus, it will support clinical decision-making and, furthermore, it will be helpful in the planning of treatment trials.
  
  
  BACKGROUND
  DRKS00000725.
authors.affiliation: Department of Neurology, Klinikum Osnabrück, Am Finkenhügel 1, D-49078, Osnabrück, Germany. christoph.kellinghaus@klinikum-os.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Kellinghaus
authors.affiliation: Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, D-24105, Kiel, Germany. n.lang@neurologie.uni-kiel.de.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lang
authors.affiliation: Department of Clinical Neurosciences, CHUV and University of Lausanne, CH-1011, Lausann, Switzerland. andrea.rossetti@chuv.ch.
authors.forename: Andrea O
authors.initials: AO
authors.lastname: Rossetti
authors.affiliation: Department of Neurology, University Hospital Basel, Petersgraben 4, CH-4031, Basel, Switzerland. stephan.rueegg@usb.ch.
authors.forename: Stephan
authors.initials: S
authors.lastname: Rüegg
authors.affiliation: Department of Neurology, Krankenhaus Barmherzige Brüder Regensburg, Prüfeninger Str. 86, D-93049, Regensburg, Germany. christian.tilz@barmherzige-regensburg.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Tilz
authors.affiliation: Department of Neurology, Christian Doppler Klinik of Paracelsus Medical University, Ignaz Harrerstarsse 79, A-5020, Salzburg, Austria. e.trinka@salk.at.|Centre for cognitive Neuroscience Salzburg, A-5020, Salzburg, Austria. e.trinka@salk.at.
authors.forename: Eugen
authors.initials: E
authors.lastname: Trinka
authors.affiliation: Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020, Innsbruck, Austria. iris.unterberger@i-med.ac.at.
authors.forename: Iris
authors.initials: I
authors.lastname: Unterberger
authors.affiliation: Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, D-89081, Ulm, Germany. zeljkou@gmail.com.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Uzelac
authors.affiliation: Epilepsy Center Hessen - Marburg, Department of Neurology, University Hospitals and Philipps-University Marburg, Rudolf-Bultmann-Strasse 8, D-35039, Marburg, Germany. rosenow@med.uni-marburg.de.
authors.forename: Felix
authors.initials: F
authors.lastname: Rosenow
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D008875:Middle Aged; D010672:Phenytoin / Q000627:therapeutic use; D011446:Prospective Studies; D012042:Registries; D013226:Status Epilepticus / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin; D008140:Lorazepam; D003975:Diazepam; D008874:Midazolam