title: Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix.
abstract: Fibroblasts have a central role in wound healing via matrix production, remodeling, and contraction. Their role as mechanoresponsive cells during tissue repair is evident, but the molecular mechanisms of this process remain uncertain. Filamin A, an intracellular protein that stabilizes the actin cytoskeleton regulates fibroblast-matrix interactions. Fibroblast defects in cytoskeletal dynamics may underlie key aspects of chronic wound pathophysiology.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, School of Medicine, Stanford University, Stanford, California, USA. Electronic address: ggurtner@stanford.edu.
authors.forename: Geoffrey C
authors.initials: GC
authors.lastname: Gurtner
authors.affiliation: Division of Plastic Surgery, Department of Surgery, School of Medicine, Stanford University, Stanford, California, USA.
authors.forename: Victor W
authors.initials: VW
authors.lastname: Wong
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D064448:Filamins / Q000378:metabolism*; D008297:Male; D013718:Tensile Strength / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000378:metabolism*
chemical_list: D064448:Filamins