title: Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies.
abstract: Bioactive 1,1'-(4,4'-di-ferrocenyl)di-phenyl thiourea and various metal complexes of this ligand have been successfully synthesized and characterized by using physicoanalytical techniques such as FT-IR and multinuclear ((1)H and (13)C) NMR spectroscopy along with melting point and elemental analyses. The interaction of the synthesized compounds with DNA has been investigated by using cyclic voltammetric and viscometric measurements. The intercalation of the complexes into the double helix structure of DNA is presumably occurring. Viscosity measurements of the complexes have shown that there is a change in length and this is regarded as the least ambiguous and the most critical test of the binding model in solution. The relative potential of the complexes as anti-bacterial, antifungal, and inhibition agents against the enzyme, alkaline phosphatase EC 3.1.3.1, has also been assessed and the complexes were found to be active inhibitors.
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology Ministry of Education, Beijing 100029, China ; Department of Chemistry, McGill University, Montreal, QC, Canada H3A 2K6.
authors.forename: Shafqat
authors.initials: S
authors.lastname: Ali
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology Ministry of Education, Beijing 100029, China.
authors.forename: Ghulam
authors.initials: G
authors.lastname: Yasin
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology Ministry of Education, Beijing 100029, China.
authors.forename: Zareen
authors.initials: Z
authors.lastname: Zuhra
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology Ministry of Education, Beijing 100029, China.
authors.forename: Zhanpeng
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Chemistry, McGill University, Montreal, QC, Canada H3A 2K6.
authors.forename: Ian S
authors.initials: IS
authors.lastname: Butler
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Amin
authors.initials: A
authors.lastname: Badshah
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Imtiaz Ud
authors.initials: IU
authors.lastname: Din