title: The effect of FT500 Plus(®) on ovarian stimulation in PCOS women.
abstract: Both oxidative stress and polycystic ovary syndrome have been involved in several aspects of female reproduction. In this retrospective observational study, the outcome of controlled ovarian stimulation and follicular microenvironment of twenty-five women affected by PCOS (Group A) have been explored, evaluating the effects of myo-inositol in association with antioxidant activities (FT500 Plus(®)). Twenty-five untreated-PCOS women (Group B) with similar characteristics served as control group. Although there was no difference in ovarian volume at time zero, this parameter was significantly smaller at the 5-month follow-up in the Group A (11.1±0.9 versus 13.5±1; P=0.0001). Group A showed a significant increase in the number of MII oocytes (6.3±2.5 versus 4.5±2; P=0.03) and glutathione peroxidase activity in follicular fluid (15.4±6.2 versus 11±2.2; P=0.04). FT500 Plus(®) may be considered in PCOS patient for improving oocyte quality.
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: alviggi@unina.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Alviggi
authors.affiliation: CEINGE Biotecnologie Avanzate, via G. Salvatore 486, 80145 Naples, Italy; Department of Clinical Medicine and Surgery, Endocrinology Section, University "Federico II", via Pansini 5, 80131 Naples, Italy. Electronic address: federicacariati@hotmail.it.
authors.forename: Federica
authors.initials: F
authors.lastname: Cariati
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: confale@hotmail.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Conforti
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: derosap85@gmail.com.
authors.forename: Pasquale
authors.initials: P
authors.lastname: De Rosa
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: robyvallone@hotmail.it.
authors.forename: Roberta
authors.initials: R
authors.lastname: Vallone
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: ida.strina@unina.it.
authors.forename: Ida
authors.initials: I
authors.lastname: Strina
authors.affiliation: Department of Clinical Medicine and Surgery, Endocrinology Section, University "Federico II", via Pansini 5, 80131 Naples, Italy. Electronic address: rosario.pivonello@unina.it.
authors.forename: Rosario
authors.initials: R
authors.lastname: Pivonello
authors.affiliation: Department of Neuroscience, Reproductive Medicine, Odontostomatology-University of Naples "Federico II", via Sergio Pansini 5, 80131 Naples, Italy. Electronic address: gdeplaci@unina.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Placido
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005492:Folic Acid / Q000627:therapeutic use*; D015571:Follicular Fluid / Q000378:metabolism; D005978:Glutathione / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D007294:Inositol / Q000627:therapeutic use*; D054315:Oocyte Retrieval; D009865:Oocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D018384:Oxidative Stress / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000175:diagnosis; D011247:Pregnancy; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; C000612875:FT500 Plus; D005300:Fertility Agents, Female; D007294:Inositol; D005492:Folic Acid; D005979:Glutathione Peroxidase; D005978:Glutathione
keywords: Follicular fluid; Oxidative stress; PCOS