title: Effect of Tamsulosin in Lower Urinary Tract Symptom Patients With Metabolic Syndrome.
abstract: OBJECTIVE
  To investigate the efficacy of tamsulosin, a selective alpha-1 blocker, in lower urinary tract symptoms (LUTS) patients with metabolic syndrome (MS).
  
  
  METHODS
  This prospective, multicenter clinical trial included men and women (20-75 years old) with LUTS, with or without MS. Patients were categorized as MS+ or MS-, respectively, and all of them were administered tamsulosin 0.2 mg per oral once daily for 24 weeks. Patients were assessed based on the International Prostate Symptom Score, King's Health Questionnaire (KHQ), Overactive Bladder Questionnaire, uroflowmetry with postvoid residuals, and MS factors (blood pressure, waist-to-hip ratio, and serum levels of fasting blood glucose, triglyceride, and high-density lipoprotein cholesterol) at baseline and at 4, 12, and 24 weeks of treatment.
  
  
  RESULTS
  Ninety-two patients were enrolled in this study (53/92 were MS- [57.6%]; 39/92 were MS+ [42.4%]). After 24 weeks of tamsulosin treatment, fasting blood glucose (P = .02) and triglyceride (P < .001) levels of changes were significantly greater in the MS+ group than in the MS- group. Total International Prostate Symptom Score, total Overactive Bladder Questionnaire score, and the scores of each question on the KHQ showed significant improvement after treatment without intergroup differences. In KHQ, although improvements in emotional status, sleep quality, fatigue, and personal distress were greater in the MS+ group (P = .05), the difference between the groups did not reach statistical significance.
  
  
  CONCLUSIONS
  Tamsulosin was effective in both LUTS patients with and without MS. Furthermore, tamsulosin had beneficial effects on some of the factors associated with MS.
authors.affiliation: Department of Urology, Ewha Womans University School of Medicine, Seoul, Republic of Korea. Electronic address: wowhana@ewha.ac.kr.
authors.forename: Hana
authors.initials: H
authors.lastname: Yoon
authors.affiliation: Department of Urology, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
authors.forename: Hyun Suk
authors.initials: HS
authors.lastname: Yoon
authors.affiliation: Department of Urology, Hallym University College of Medicine, Seoul, Republic of Korea.
authors.forename: Yong Seong
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Department of Urology, Hallym University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Cho
authors.affiliation: Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Deok Hyun
authors.initials: DH
authors.lastname: Han
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D011446:Prospective Studies; D013449:Sulfonamides / Q000627:therapeutic use*; D000077409:Tamsulosin; D016896:Treatment Outcome
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin