title: Blood-Conservation Strategies in a Blood-Refusal Parturient with Placenta Previa and Placenta Percreta.
abstract: Abnormal placentation can be associated with significant blood loss and massive blood transfusions. Caring for parturients with abnormal placentation who refuse blood transfusion is very challenging. We present a 35-year-old, gravida 3, para 1, Jehovah's Witness at 35 weeks of gestation with placenta percreta, who underwent cesarean delivery and delayed hysterectomy. A multidisciplinary team developed a plan, including the use of perioperative erythropoietin and IV iron dextran, intraoperative acute normovolemic hemodilution, cell salvage, tranexamic acid, and uterine artery embolization. This strategy was successful in avoiding the need for allogeneic transfusion and ensuring an uneventful recovery after both surgical procedures.
authors.affiliation: From the Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina.
authors.forename: Amy A
authors.initials: AA
authors.lastname: Mauritz
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Dominguez
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Guinn
authors.forename: Jennifer
authors.initials: J
authors.lastname: Gilner
authors.forename: Ashraf S
authors.initials: AS
authors.lastname: Habib
mesh_terms: D000328:Adult; D057668:Bloodless Medical and Surgical Procedures / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods*; D004921:Erythropoietin / Q000008:administration & dosage; D005260:Female; D006438:Hemodilution / Q000379:methods; D006801:Humans; D007505:Iron-Dextran Complex / Q000008:administration & dosage; D033221:Jehovah's Witnesses; D010921:Placenta Accreta / Q000628:therapy*; D010923:Placenta Previa / Q000628:therapy*; D011247:Pregnancy; D014148:Tranexamic Acid / Q000008:administration & dosage; D016896:Treatment Outcome; D055357:Uterine Artery Embolization / Q000379:methods
chemical_list: D004921:Erythropoietin; D014148:Tranexamic Acid; D007505:Iron-Dextran Complex