title: Characterizing Awake and Anesthetized States Using a Dimensionality Reduction Method.
abstract: Distinguishing between awake and anesthetized states is one of the important problems in surgery. Vital signals contain valuable information that can be used in prediction of different levels of anesthesia. Some monitors based on electroencephalogram (EEG) such as the Bispectral (BIS) index have been proposed in recent years. This study proposes a new method for characterizing between awake and anesthetized states. We validated our method by obtaining data from 25 patients during the cardiac surgery that requires cardiopulmonary bypass. At first, some linear and non-linear features are extracted from EEG signals. Then a method called "LLE"(Locally Linear Embedding) is used to map high-dimensional features in a three-dimensional output space. Finally, low dimensional data are used as an input to a quadratic discriminant analyzer (QDA). The experimental results indicate that an overall accuracy of 88.4 % can be obtained using this method for classifying the EEG signal into conscious and unconscious states for all patients. Considering the reliability of this method, we can develop a new EEG monitoring system that could assist the anesthesiologists to estimate the depth of anesthesia accurately.
authors.affiliation: School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Mirsadeghi
authors.affiliation: School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran. behnam@iust.ac.ir.
authors.forename: H
authors.initials: H
authors.lastname: Behnam
authors.affiliation: School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Shalbaf
authors.affiliation: Department of Anesthesia, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Jelveh Moghadam
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D000758:Anesthesia / Q000379:methods*; D002315:Cardiopulmonary Bypass / Q000379:methods; D016002:Discriminant Analysis; D004569:Electroencephalography / Q000295:instrumentation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D014474:Unconsciousness; D014851:Wakefulness
keywords: Dimensionality reduction; Electroencephalogram (EEG); Locally linear embedding (LLE); Monitoring the depth of anesthesia