title: Preoperative Prolapse Stage as Predictor of Failure of Sacrocolpopexy.
abstract: Our aim was to determine if there was a correlation between the preoperative prolapse stage and postoperative recurrence of prolapse 1 year after sacrocolpopexy. Our null hypothesis is that the preoperative stage of prolapse does not increase the risk of recurrence.
  
  
  
  This is a multicenter cohort study from 3 centers. We included subjects who underwent robotic-assisted sacrocolpopexy and completed a standardized 1-year follow-up from 2009-2014. All subjects underwent a complete preoperative evaluation and completed 12 months of follow-up with the pelvic organ prolapse quantification examination. We compared those subjects who met the definition of recurrence with those who did not, analyzing the following covariates: stage of prolapse using International Continence Society (ICS) definitions, individual pelvic organ prolapse quantification points, age, body mass index, race, exogenous estrogen use, menopause, smoking, vaginal parity, cesarean section, and performance of concomitant procedures. We defined recurrence as any prolapse beyond the hymen.
  
  
  
  We had 125 women from 3 centers who met our criteria, with 23.2% of them having recurrence at 1 year. We found that recurrence increased as the preoperative ICS stage of prolapse increased (P = <0.001 in the univariate model). In the multivariate model, using logistic regression, we found that the risk of recurrence of pelvic organ prolapse increased as the presurgery clinical stage increased with an odds ratio of 3.8 (95% confidence interval, 1.5-9) when controlling for age, menopausal status, and genital hiatus (P = 0.004).
  
  
  
  Much like a higher stage of disease in oncology, we found that increasing stage of prolapse preoperatively increased the risk of recurrence at 1 year after sacrocolpopexy.
authors.affiliation: From the *Oregon Health & Science University; †Legacy Good Samaritan Medical Center, Portland, OR; and ‡University of North Carolina, Chapel Hill, NC.
authors.forename: Muhammad F
authors.initials: MF
authors.lastname: Aslam
authors.forename: Blake
authors.initials: B
authors.lastname: Osmundsen
authors.forename: Sharon R
authors.initials: SR
authors.lastname: Edwards
authors.forename: Catherine
authors.initials: C
authors.lastname: Matthews
authors.forename: William T
authors.initials: WT
authors.lastname: Gregory
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D016017:Odds Ratio; D056887:Pelvic Organ Prolapse / Q000473:pathology / Q000601:surgery*; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index; D017211:Treatment Failure