title: Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD(+)-dependent HDAC inhibitor.
abstract: Exposure of the fungus Chaetomium cancroideum to an NAD(+)-dependent HDAC inhibitor, nicotinamide, enhanced the production of aromatic and branched aliphatic polyketides, which allowed us to isolate new secondary metabolites, chaetophenol G and cancrolides A and B. Their structures were determined using spectroscopic analyses, and their absolute configuration was elucidated by electronic circular dichroism (ECD), vibrational circular dichroism (VCD), and chemical transformations. Biosynthesis of the branched aliphatic polyketide skeletons in cancrolides A and B was evidenced by conducting a feeding experiment using compounds labeled with a (13)C stable isotope.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan. tasai@m.tohoku.ac.jp.
authors.forename: Teigo
authors.initials: T
authors.lastname: Asai
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Morita
authors.forename: Tohru
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Monde
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Oshima
mesh_terms: D002597:Chaetomium / Q000187:drug effects* / Q000378:metabolism*; D045325:HCT116 Cells; D056572:Histone Deacetylase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008968:Molecular Conformation; D009243:NAD / Q000378:metabolism* / Q000494:pharmacology; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D056572:Histone Deacetylase Inhibitors; D061065:Polyketides; D009243:NAD; D006655:Histone Deacetylases