title: Electrospun polyvinyl alcohol-polyvinyl pyrrolidone nanofibrous membranes for interactive wound dressing application.
abstract: Cross-linked polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) composite nanofibrous membranes have been prepared by electrospinning. Mechanical properties of the membranes improved significantly with PVP addition. PVP improved hydrophilicity and sustainable degradation of the membranes. Biocompatibility of the membranes was assessed by in vitro culture of native skin cells (L929 fibroblast and HaCaT keratinocytes). Tests showed sustained release of the antibiotic ciprofloxacin hydrochloride monohydrate by the membranes. Further, zone of inhibition study against Staphylococcus aureus growth demonstrated protective action against external pathogenic microbes. These studies show these simple PVA-PVP nanofibrous membranes are promising interactive antibiotic-eluting wound dressing materials.
authors.affiliation: a Department of Physics , Indian Institute of Technology Guwahati , Guwahati , India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Shankhwar
authors.affiliation: b Biomaterials Tissue Engineering Laboratory, Department of Biosciences Bioengineering , Indian Institute of Technology Guwahati , Guwahati , India.
authors.forename: Manishekhar
authors.initials: M
authors.lastname: Kumar
authors.affiliation: b Biomaterials Tissue Engineering Laboratory, Department of Biosciences Bioengineering , Indian Institute of Technology Guwahati , Guwahati , India.
authors.forename: Biman B
authors.initials: BB
authors.lastname: Mandal
authors.affiliation: c Department of Mechanical Engineering , Indian Institute of Technology Guwahati , Guwahati , India.
authors.forename: P S
authors.initials: PS
authors.lastname: Robi
authors.affiliation: a Department of Physics , Indian Institute of Technology Guwahati , Guwahati , India.
authors.forename: A
authors.initials: A
authors.lastname: Srinivasan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001458:Bandages; D002460:Cell Line; D049109:Cell Proliferation; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics; D004553:Electric Conductivity; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000502:physiology; D008422:Materials Testing; D051379:Mice; D057139:Nanofibers / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000503:physiopathology; D013211:Staphylococcus aureus; D014783:Viscosity; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D014867:Water; D002939:Ciprofloxacin; D011142:Polyvinyl Alcohol; D011205:Povidone
keywords: Electrospinning; antimicrobial; cell affinity; polyvinyl alcohol; polyvinyl pyrrolidone; wound dressings