title: HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling.
abstract: The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus associated with both proliferative and inflammatory disorders. This virus causes a persistent infection, mainly in CD4+ T lymphocyte. The ability to persist in the host is associated with the virus capacity to evade the immune response and to induce infected T-cell proliferation, once the HTLV-1 maintains the infection mainly by clonal expansion of infected cells. There are several evidences that ORF-I encoded proteins, such as p12 and p8, play an important role in this context. The present study will review the molecular mechanisms that HTLV-1 ORF-I encoded proteins have to induce dysregulation of intracellular signaling, in order to escape from immune response and to increase the infected T-cell proliferation rate. The work will also address the impact of ORF-I mutations on the human host and perspectives in this study field.
authors.affiliation: Universidade Federal do Rio de Janeiro (UFRJ), Rua Rodolpho Paulo Rocco 255, 3° Andar, Cidade Universitária, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, Brazil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Rosadas
authors.affiliation: Universidade Federal do Rio de Janeiro (UFRJ), Rua Rodolpho Paulo Rocco 255, 3° Andar, Cidade Universitária, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, Brazil ; Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, Tijuca, 20270-901 Rio de Janeiro, RJ, Brazil.
authors.forename: Marzia
authors.initials: M
authors.lastname: Puccioni-Sohler
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D049109:Cell Proliferation; D054884:Host-Pathogen Interactions; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D057131:Immune Evasion; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D009154:Mutation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D054334:Viral Regulatory and Accessory Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D054334:Viral Regulatory and Accessory Proteins; C084305:p12I protein, Human T-lymphotropic virus 1