title: Correlation between GDF 15 gene polymorphism and the collateral circulation in acute non-ST segment elevated myocardial infarction.
abstract: OBJECTIVE
  To investigate the correlation between growth differentiation factor 15 (GDF 15) + 157 A/T polymorphism and the formation of collateral circulation in acute non-ST segment elevated myocardial infarction in Han population of Shandong province.
  
  
  METHODS
  The medical records of 200 cases of patients undergoing selective coronary angiography were analyzed, and the arterial blood specimens of included patients were collected before coronary angiography. Based on the results of coronary angiography, patients were divided into acute myocardial infarction (AMI) group and normal control group; AMI group was divided into collateral group and non-collateral group by Rentrop's grading method; polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods were used to analyze the GDF 15 + 157 A/T polymorphism in the two groups.
  
  
  RESULTS
  There were statistically significant differences in GDF 15 + 157 A/T AA and AT distribution between AMI group and the control group (P = 0.002); and there was statistically significant difference in allele frequencies between the two groups (P = 0.006); for AMI group, there were statistically significant differences in GDFAA and AT genotype distribution between patients with and without collateral (P = 0.014), and there was statistically significant difference in allele frequencies between the two (P = 0.025).
  
  
  CONCLUSIONS
  There was correlation between GDF 15 + 157 A/T polymorphism and the formation of collateral circulation in patients with non-ST-segment elevated myocardial infarction.
authors.affiliation: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Jing
authors.affiliation: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Qiying
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Emergency, Xiangya Hospital, Central South University Changsha 410008, China.
authors.forename: Zhaoxin
authors.initials: Z
authors.lastname: Qian
keywords: Acute myocardial infarction; Collateral circulation; GDF 15; Gene polymorphism; PCR-RFLP; SNPs