title: Comparison of brimonidine-timolol and dorzolamide-timolol in the management of intraocular pressure increase after phacoemulsiﬁcation.
abstract: OBJECTIVE
  To compare the effectiveness of brimonidine/timolol fixed combination (BTFC) and dorzolamide/timolol fixed combination (DTFC) in the management of short-term intraocular pressure (IOP) increase after phacoemulsiﬁcation surgery.
  
  
  METHODS
  Eighty eyes of 80 patients undergoing phacoemulsiﬁcation and intraocular lens (IOL) implantation were randomly assigned into three groups. Group 1 consisted of 28 eyes and represented the control group. Group 2 consisted of 25 eyes undergoing phacoemulsiﬁcation surgery and BTFC was instilled at the end of surgery. Group 3 consisted of 27 eyes undergoing phacoemulsiﬁcation surgery and DTFC was instilled at the end of surgery. IOP was measured preoperatively and 6, 24h and 1wk postoperatively.
  
  
  RESULTS
  There was no statistically signiﬁcant difference in preoperative baseline IOP among the three groups (P=0.84). However, IOP was significantly lower in groups 2 and 3 compared to the control group (P<0.05 for all comparisons) at all postoperative visits. There was no significant difference between groups 2 and 3 at any visit. Eight eyes (28.6%) in the control group, two (8%) in Group 2 and one (3.7%) in Group 3 had IOP >25 mm Hg at 6h after surgery (P=0.008). However, IOP decreased and was >25 mm Hg in only one eye in each group at 24h after surgery.
  
  
  CONCLUSIONS
  BTFC and DTFC have similar effects in reducing increases in IOP after phacoemulsification surgery and can both be recommended for preventing IOP spikes after such surgery.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Turk
authors.affiliation: Department of Ophthalmology, Medical Park Hospital, Ankara 06370, Turkey.
authors.forename: Osman Melih
authors.initials: OM
authors.lastname: Ceylan
authors.affiliation: Department of Ophthalmology, Kayseri Military Hospital, Kayseri 38100, Turkey.
authors.forename: Gokcen
authors.initials: G
authors.lastname: Gokce
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Mevlana University, Konya 42003, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Borazan
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kola
keywords: brimonidine; cataract; dorzolamide; intraocular pressure; phacoemulsification; postoperative complication; timolol