title: Small molecule screen identifies differentiation-promoting compounds targeting genetically diverse acute myeloid leukaemia.
authors.affiliation: Department of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden.|Department of Haematopoietic Stem Cell Transplantation, Lund University, Lund, Sweden.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Baudet
authors.affiliation: Department of Chemical Biology & Therapeutics, Lund University, Lund, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Ek
authors.affiliation: Department of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden.
authors.forename: Josef
authors.initials: J
authors.lastname: Davidsson
authors.affiliation: Department of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden.
authors.forename: Shamit
authors.initials: S
authors.lastname: Soneji
authors.affiliation: Department of Chemical Biology & Therapeutics, Lund University, Lund, Sweden.
authors.forename: Roger
authors.initials: R
authors.lastname: Olsson
authors.affiliation: Department of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden. mattias.magnusson@med.lu.se.
authors.forename: Mattias
authors.initials: M
authors.lastname: Magnusson
authors.affiliation: Department of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden. jorg.cammenga@med.lu.se.|Departments of Haematology, Skanes University Hospital, Lund University, Lund, Sweden. jorg.cammenga@med.lu.se.
authors.forename: Jörg
authors.initials: J
authors.lastname: Cammenga
authors.affiliation: Department of Haematopoietic Stem Cell Transplantation, Lund University, Lund, Sweden.|Departments of Haematology, Skanes University Hospital, Lund University, Lund, Sweden.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Juliusson
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects*; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D055088:Early Detection of Cancer / Q000379:methods*; D014644:Genetic Variation; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics*; D054852:Small Molecule Libraries / Q000627:therapeutic use*
chemical_list: D007211:Indoles; D054852:Small Molecule Libraries; C027185:indirubin
keywords: acute myeloid leukaemia-initiating cells; differentiation; small molecule screen