title: Identification of BRAF Kinase Domain Duplications Across Multiple Tumor Types and Response to RAF Inhibitor Therapy.
authors.affiliation: Division of Hematology-Oncology, University of California Irvine, Orange.
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Klempner
authors.affiliation: Georgia Cancer Specialists, Sandy Springs3Northside Hospital Cancer Institute, Sandy Springs, Georgia.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Bordoni
authors.affiliation: Foundation Medicine Inc, Cambridge, Massachusetts.
authors.forename: Kyle
authors.initials: K
authors.lastname: Gowen
authors.affiliation: Swedish Cancer Institute, Seattle, Washington.
authors.forename: Henry
authors.initials: H
authors.lastname: Kaplan
authors.affiliation: Foundation Medicine Inc, Cambridge, Massachusetts6Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, New York.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Stephens
authors.affiliation: Division of Hematology-Oncology, University of California Irvine, Orange.
authors.forename: Sai-Hong Ignatius
authors.initials: SH
authors.lastname: Ou
authors.affiliation: Foundation Medicine Inc, Cambridge, Massachusetts.
authors.forename: Siraj M
authors.initials: SM
authors.lastname: Ali
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018267:Carcinoma, Acinar Cell / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D004252:DNA Mutational Analysis; D005260:Female; D020440:Gene Duplication; D020869:Gene Expression Profiling; D006801:Humans; D009154:Mutation; D010307:Parotid Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D057285:Precision Medicine; D011237:Predictive Value of Tests; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D017434:Protein Structure, Tertiary; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf