title: [Low-dose Radioiodine for Ablation in Non-metastatic High-risk Thyroid Cancer].
abstract: OBJECTIVE
  To evaluate the role of low-dose radioiodine in the treatment of non-metastatic high-risk differentiated thyroid cancer (DTC) patients with macroscopic extra-thyroidal extension (MAEE).
  
  
  METHODS
  Totally 103 DTC patients with total/near-total thyroidectomy and selective lymph node resection, and with MAEE, any N stage,preablative stimulated thyroglobulin (ps-Tg) ≤ 5 ng/ml when thyroglobulin antibodies (TgAb) ≤ 46 U/ml and no evidence of distant metastasis were retrospectively analyzed in this study. Fifty-two received low dose RAI (1110 MBq) and 51 received high dose (≥ 3700 MBq). The successful ablation rate and disease-free survival rate were compared between these two groups.
  
  
  RESULTS
  The successful ablative rate was 86.5% (45/52) in low-dose group and 86.3% (44/51) in high-dose group (P=0.9688), and the disease-free survival was 97.4% (38/39) in low-dose group and 97.5% (39/40) in high-dose group.
  
  
  CONCLUSIONS
  The ablation success and medium-term clinical outcome with low-dose RAI is proved to be non-inferior to high dose in non-metastatic patients with MAEE when ps-Tg level is less than 5 ng/ml.
authors.affiliation: Department of Nuclear Medicine，PUMC Hospital，CAMS and PUMC，Beijing 100730，China.
authors.forename: Ying-jie
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Hematology and Oncology Center,Peking University International Hospital,Beijing 102206,China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Nuclear Medicine，PUMC Hospital，CAMS and PUMC，Beijing 100730，China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Nuclear Medicine，PUMC Hospital，CAMS and PUMC，Beijing 100730，China.
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.affiliation: Department of Nuclear Medicine，PUMC Hospital，CAMS and PUMC，Beijing 100730，China.
authors.forename: Yan-song
authors.initials: YS
authors.lastname: Lin
mesh_terms: D001323:Autoantibodies; D018572:Disease-Free Survival; D006801:Humans; D007457:Iodine Radioisotopes; D012189:Retrospective Studies; D013954:Thyroglobulin; D013964:Thyroid Neoplasms; D013965:Thyroidectomy
chemical_list: D001323:Autoantibodies; D007457:Iodine Radioisotopes; C006606:anti-thyroglobulin; D013954:Thyroglobulin