title: Vitamin D levels and breast cancer characteristics: Findings in patients from Saudi Arabia.
abstract: Inverse relationship between vitamin D status and risk of breast cancer has been previously reported in the literature. We conducted this study to determine the association between vitamin D levels and breast cancer characteristics in patients from Saudi Arabia. Newly diagnosed breast cancer patients (N=406) were recruited. Serum levels of 25-hydroxyvitamin D [25 (OH) D] were measured at baseline. A significantly higher percentage of patients with triple negative status (18%) had 25 (OH) D levels ≤25nmol/L, compared to only 8% with 25 (OH) D levels >25nmol/L (p=0.009). Patients with 25 (OH) D levels ≤25nmol/L were 2.54 times more likely to present with triple negative status compared to those with 25 (OH) D levels >25nmol/L (p=0.02). Our findings suggest an association between low 25 (OH) D levels and increased risk of triple negative breast cancer.
authors.affiliation: Department of Oncology, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Saudi Arabia.
authors.forename: Omalkhair
authors.initials: O
authors.lastname: Abulkhair
authors.affiliation: Department of Oncology, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Saadeddin
authors.affiliation: Department of Oncology, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Saudi Arabia.
authors.forename: Olaa
authors.initials: O
authors.lastname: Makram
authors.affiliation: Department of Oncology, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Gasmelseed
authors.affiliation: Department of Oncology, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Saudi Arabia.
authors.forename: Tabrez
authors.initials: T
authors.lastname: Pasha
authors.affiliation: Department of Oncology, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Saudi Arabia.
authors.forename: Hussam
authors.initials: H
authors.lastname: Shehata
authors.affiliation: Basic Sciences Department, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, P.O.box 3660, Mail code 3127, Riyadh 11481, Saudi Arabia,. Electronic address: hana.fakhoury@gmail.com.
authors.forename: Hana M
authors.initials: HM
authors.lastname: Fakhoury
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood* / Q000453:epidemiology; D018567:Breast Neoplasms, Male / Q000097:blood* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D011379:Prognosis; D012529:Saudi Arabia / Q000453:epidemiology; D064726:Triple Negative Breast Neoplasms / Q000097:blood* / Q000453:epidemiology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood*; D014808:Vitamin D Deficiency / Q000150:complications
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Breast cancer; Saudi Arabia; Triple negative; Vitamin D