title: Placental Massive Perivillous Fibrinoid Deposition Associated with Coxsackievirus A16-Report of a Case, and Review of the Literature.
abstract: Massive placental perivillous fibrinoid deposition in the placenta is thought to be an immune-related condition associated with poor perinatal outcomes, including growth restriction and intrauterine fetal demise, with a high risk of recurrence. Rare cases have been associated with Coxsackievirus infection. We present such a case and review the literature.
authors.affiliation: 1  Department of Pathology & Laboratory Medicine, UH/E158, Rutgers-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, USA.
authors.forename: Debra S
authors.initials: DS
authors.lastname: Heller
authors.affiliation: 2  Provincial Laboratory for Public Health, Calgary, AB, Canada.|3  Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.
authors.forename: Raymond
authors.initials: R
authors.lastname: Tellier
authors.affiliation: 2  Provincial Laboratory for Public Health, Calgary, AB, Canada.
authors.forename: Kanti
authors.initials: K
authors.lastname: Pabbaraju
authors.affiliation: 2  Provincial Laboratory for Public Health, Calgary, AB, Canada.
authors.forename: Sallene
authors.initials: S
authors.lastname: Wong
authors.affiliation: 4  Department of Pathology, University of Alabama, Birmingham, AL, USA.
authors.forename: Ona M
authors.initials: OM
authors.lastname: Faye-Petersen
authors.affiliation: 5  Infectious Diseases Pathology Branch Division of High-Consequence Pathogens and Pathology NCEZID, CDC, Atlanta, GA, USA.
authors.forename: Atis
authors.initials: A
authors.lastname: Muehlenbachs
authors.affiliation: 5  Infectious Diseases Pathology Branch Division of High-Consequence Pathogens and Pathology NCEZID, CDC, Atlanta, GA, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Goldsmith
authors.affiliation: 5  Infectious Diseases Pathology Branch Division of High-Consequence Pathogens and Pathology NCEZID, CDC, Atlanta, GA, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Denison
authors.affiliation: 5  Infectious Diseases Pathology Branch Division of High-Consequence Pathogens and Pathology NCEZID, CDC, Atlanta, GA, USA.
authors.forename: Sherif R
authors.initials: SR
authors.lastname: Zaki
mesh_terms: D003384:Coxsackievirus Infections / Q000150:complications*; D005260:Female; D005333:Fetus; D006801:Humans; D066087:Perinatal Death / Q000209:etiology*; D010920:Placenta / Q000473:pathology; D010922:Placenta Diseases / Q000473:pathology* / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology / Q000821:virology*
keywords: Coxsackievirus A16 infection; hand-foot-mouth disease; intrauterine fetal death; massive placental perivillous fibrinoid deposition