title: [CRISPR-Cas9, a new chance for somatic gene therapy].
abstract: Targeted modification of genes ("gene editing") is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; however this technology has less controversial applications, notably for somatic gene therapy with already some striking demonstrations in animal systems. Because of its precision and relative ease of use, CRISPR can be expected to drive a revolution in gene therapy and to turn it into a more mainstream approach.
authors.affiliation: UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS, Espace éthique méditerranéen, hôpital d'adultes la Timone, 264, rue Saint-Pierre, 13385 Marseille Cedex 05, France ; CoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Jordan
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000331:legislation & jurisprudence / Q000639:trends; D064113:CRISPR-Cas Systems / Q000502:physiology*; D064112:Clustered Regularly Interspaced Short Palindromic Repeats / Q000502:physiology*; D000229:Dependovirus / Q000235:genetics; D004345:Drug Industry / Q000331:legislation & jurisprudence; D005818:Genetic Engineering / Q000331:legislation & jurisprudence / Q000379:methods; D015316:Genetic Therapy / Q000331:legislation & jurisprudence / Q000379:methods*; D006801:Humans; D000094704:RNA, Guide, CRISPR-Cas Systems / Q000235:genetics
chemical_list: D000094704:RNA, Guide, CRISPR-Cas Systems