title: [Ageing: a matter of heart?].
abstract: Ageing is considered as a major risk factor for the development of chronic diseases. Among these, heart failure seems to be particularly important for both triggering and accelerating pathological ageing. In the present review, we give a general overview of the most relevant results concerning the mechanism of normal and premature senescence of cardiomyocytes and cardiac stromal cells. In particular, we will address the role of telomere dysfunction, DNA damage response, impairment of mitochondrial function, miRNAs and secretome of senescent cells in cardiac ageing and failure.
authors.affiliation: Inserm, UMR1048, institut des maladies métaboliques et cardiovasculaires, 1, avenue Jean Poulhès, BP 84225, 31432 Toulouse cedex 4, France - Université Paul Sabatier, Toulouse, France.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Mialet-Perez
authors.affiliation: Inserm, UMR1048, institut des maladies métaboliques et cardiovasculaires, 1, avenue Jean Poulhès, BP 84225, 31432 Toulouse cedex 4, France - Université Paul Sabatier, Toulouse, France.
authors.forename: Victorine
authors.initials: V
authors.lastname: Douin-Echinard
authors.affiliation: Inserm, UMR1048, institut des maladies métaboliques et cardiovasculaires, 1, avenue Jean Poulhès, BP 84225, 31432 Toulouse cedex 4, France - Université Paul Sabatier, Toulouse, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Cussac
authors.affiliation: Institut de recherches internationales Servier, Suresnes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Bril
authors.affiliation: Inserm, UMR1048, institut des maladies métaboliques et cardiovasculaires, 1, avenue Jean Poulhès, BP 84225, 31432 Toulouse cedex 4, France - Université Paul Sabatier, Toulouse, France.
authors.forename: Angelo
authors.initials: A
authors.lastname: Parini
mesh_terms: D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology; D004249:DNA Damage / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D032383:Myocytes, Cardiac / Q000502:physiology; D020543:Proteome / Q000378:metabolism; D016615:Telomere / Q000502:physiology
chemical_list: D020543:Proteome