title: Massive oral bleeding after full-mouth extraction in a patient with B-cell lymphocytic leukemia/small lymphocytic lymphoma reversed with recombinant activated factor VII.
abstract: BACKGROUND
  Full-mouth extraction can be associated with intraoral bleeding, which usually is controlled with local hemostatic measures. Recombinant activated factor VII (rFVIIa) occasionally is used to stop bleeding in a variety of off-label indications, with the main argument curtailing its use being thrombotic events. The authors describe the use of rFVIIa for bleeding after full-mouth extraction in a patient with undiagnosed B-cell lymphocytic leukemia/small lymphocytic lymphoma.
  
  
  METHODS
  A 72-year-old man underwent full-mouth extraction (18 teeth). The next day, the patient experienced massive oral bleeding. The authors administered tranexamic acid, aminocaproic acid, and a total of 12 units of packed red blood cells in addition to local hemostatic measures without control of bleeding. On postoperative day 10, the authors administered 5,000 micrograms of rFVIIa, and within 2 hours oral the bleeding ceased. The authors performed flow cytometry and diagnosed B-cell lymphocytic leukemia/small lymphocytic lymphoma.
  
  
  CONCLUSIONS
  Unexplained massive oral bleeding despite adequate local hemostatic measures should prompt further investigations for underlying bleeding or coagulation disorders. The authors describe the successful use of rFVIIa in massive oral bleeding. Further studies are mandatory to study the effectiveness of this drug for this off-label indication.
authors.forename: Collin
authors.initials: C
authors.lastname: Sprenker
authors.forename: Hesham R
authors.initials: HR
authors.lastname: Omar
authors.forename: R Andrew
authors.initials: RA
authors.lastname: Powless
authors.forename: Devanand
authors.initials: D
authors.lastname: Mangar
authors.forename: Enrico
authors.initials: E
authors.lastname: Camporesi
mesh_terms: D000368:Aged; D003029:Coagulants / Q000627:therapeutic use*; D015942:Factor VIIa / Q000627:therapeutic use*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D006472:Oral Hemorrhage / Q000188:drug therapy / Q000209:etiology*; D019106:Postoperative Hemorrhage / Q000188:drug therapy / Q000209:etiology*; D011994:Recombinant Proteins / Q000627:therapeutic use; D014081:Tooth Extraction / Q000009:adverse effects*
chemical_list: D003029:Coagulants; D011994:Recombinant Proteins; D015942:Factor VIIa
keywords: Recombinant activated factor VII; chronic lymphocytic leukemia; full-mouth extraction; oral bleeding; small lymphocytic lymphoma