title: Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging.
abstract: Nanotechnology and combination therapy are two major fields that show great promise in the treatment of cancer. The delivery of drugs via nanoparticles helps to improve drug's therapeutic effectiveness while reducing adverse side effects associated wifh high dosage by improving their pharmacokinetics. Taking advantage of molecular markers over-expressing on tumor tissues compared to normal cells, an "active" molecular marker targeted approach would be-beneficial for cancer therapy. These actively targeted nanoparticles would increase drug concentration at the tumor site, improving efficacy while further reducing chemo-resistance. The multidisciplinary approach may help to improve the overall efficacy in cancer therapy. This review article summarizes recent developments of targeted multifunctional nanoparticles in the delivery, of various drugs for a combinational chemotherapy approach to cancer treatment and imaging.
authors.forename: Micah D K
authors.initials: MD
authors.lastname: Glasgow
authors.forename: Mahavir B
authors.initials: MB
authors.lastname: Chougule
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D035843:Biomedical Research; D045744:Cell Line, Tumor; D050091:Dendrimers; D003952:Diagnostic Imaging; D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes; D051379:Mice; D050997:Nanomedicine; D053758:Nanoparticles / Q000627:therapeutic use*; D011108:Polymers; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D008081:Liposomes; D011108:Polymers