title: Analysis of glycosylated hemoglobin (HbA1c) level on maxillofacial fascial space infection in diabetic patients.
abstract: OBJECTIVE
  This study was performed to evaluate the impact of glycosylated hemoglobin (HbA1c) level on characteristics and prognosis of maxillofacial fascial infection in diabetic patients.
  
  
  METHODS
  We reviewed the medical records of 72 patients (35 patients with HbA1c lower than 7.0% and 37 patients with HbA1c higher than 7.0%) diagnosed with maxillofacial fascial space infection and hospitalized for treatment at the Department of Oral and Maxillofacial Surgery in Dankook University Hospital (Cheonan, Korea) from January 2005 to February 2014. We compared demographics, parameters of glucoregulation (HbA1c), laboratory parameters of inflammation (white blood cell [WBC], C-reactive protein [CRP] count), type and number of involved spaces, type and number of antibiotics, period of hospitalization, number of surgical operations, need for tracheostomy, complications, computed tomography (CT), and microorganisms between the two groups.
  
  
  RESULTS
  Compared with the well-controlled diabetes mellitus (DM) group (HbA1c <7.0%), patients in the poorly-controlled (HbA1c ≥7.0%) DM group had the following characteristics: longer hospitalization periods, higher values of laboratory parameters of inflammation (WBC, CRP count) at the time of admission, higher number of antibiotics prescribed, more frequent complications, frequent deep neck space involvement, and distinctive main causative microorganisms. As the HbA1c level increases, hospitalization periods and incidence of complications increase gradually.
  
  
  CONCLUSIONS
  This retrospective study suggests that regulation of DM significantly impacts maxillofacial fascial infection. Poorly controlled DM with high HbA1c level negatively influences the prognosis of infection.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Korea.
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Jang
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Korea.
authors.forename: Chul-Hwan
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Korea.
authors.forename: Moon-Young
authors.initials: MY
authors.lastname: Kim
keywords: Dental infection control; Diabetes mellitus; Glycosylated hemoglobin A