title: Impact of recipient ACE I/D genotype on kidney function in renal transplant patients: a meta-analysis of cross-sectional and longitudinal studies.
abstract: OBJECTIVE
  To perform a systematic review and meta-analysis of studies evaluating the influence of recipient angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism on kidney function in renal transplant recipients.
  
  
  METHODS
  A comprehensive search was performed through PubMed, Web of Knowledge and Cochrane databases up to December 2014. The methodological quality of identified studies was assessed using the MINORS criteria.
  
  
  RESULTS
  A total of 15 studies evaluating the role of recipient ACE I/D were included in the meta-analysis. In overall analyzes and subsequent subgroup and sensitivity analyzes, no evidence emerged of an effect of ACE I/D on serum creatinine levels, creatinine clearance or glomerular filtration rate.
  
  
  CONCLUSIONS
  Although further investigation is still needed to determine the role of donor ACE genotype, recipient ACE I/D does not play a significant role on kidney function in renal transplant patients.
authors.affiliation: Dipartimento di Scienze del Farmaco & Centro di Ricerca Interdipartimentale di Farmacogenetica e Farmacogenomica (CRIFF), Università del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Cargnin
authors.affiliation: Department of Translational Medicine, Nephrology & Kidney Transplant Unit, University of Eastern Piedmont, Novara, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Quaglia
authors.affiliation: Dipartimento di Scienze del Farmaco & Centro di Ricerca Interdipartimentale di Farmacogenetica e Farmacogenomica (CRIFF), Università del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy.
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Canonico
authors.affiliation: Department of Translational Medicine, Nephrology & Kidney Transplant Unit, University of Eastern Piedmont, Novara, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Stratta
authors.affiliation: Dipartimento di Scienze del Farmaco & Centro di Ricerca Interdipartimentale di Farmacogenetica e Farmacogenomica (CRIFF), Università del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Terrazzino
mesh_terms: D003430:Cross-Sectional Studies; D005838:Genotype; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation / Q000639:trends; D008137:Longitudinal Studies; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D066027:Transplant Recipients
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: ACE; allograft dysfunction; meta-analysis; polymorphisms; renal transplantation