title: Klotho protein lowered in senile patients with brady sinus arrhythmia.
abstract: OBJECTIVE
  To explore the correlationship between brady sinus arrhythmia and the levels of serum klotho protein in aged.
  
  
  METHODS
  104 patients over 75 years old with brady sinus arrhythmia (experiment group) were enrolled, including 34 cases of sinus arrest, 43 cases of sinus bradycardia and 25 cases of atrioventricular block. 109 patients over 75 years old without brady sinus arrhymia were chosen as control group. All subjects were monitored by Holter. The levels of serum klotho protein were detected and compared among three groups. The correlation between the frequency of sinus arrest and the levels of serum klotho protein was analyzed simultaneously.
  
  
  RESULTS
  The levels of serum klotho protein in experiment group were lower than that in control group (P<0.01); the sinus arrest frequency was negatively correlated with the levels of serum klotho protien. The levels of serum klotho protein in patients with sinus arrest were lower than that with sinus bradycardia and atrioventricularblock (P<0.05). But there was no significant difference between sinus bradycardia group and atrioventricular block group.
  
  
  CONCLUSIONS
  The levels of serum klotho protein may reflect the function of sinoatrial node and could be used as an index to estimate the function of sinoatrial node.
authors.affiliation: Department of Geriatric Cardiology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710061, Shaanxi, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Geriatric Cardiology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710061, Shaanxi, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Geriatric Cardiology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710061, Shaanxi, China.
authors.forename: Ernv
authors.initials: E
authors.lastname: Zheng
authors.affiliation: Department of Geriatric Cardiology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710061, Shaanxi, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Geriatric Cardiology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710061, Shaanxi, China.
authors.forename: Xianming
authors.initials: X
authors.lastname: Su
keywords: Senile; brady sinus arrhythmia; klotho