title: Genetic Variation in the Catechol-O-Methyl Transferase Val108/158Met Is Linked to the Caudate and Posterior Cingulate Cortex Volume in Healthy Subjects: Voxel-Based Morphometry Analysis of Brain Magnetic Resonance Imaging.
abstract: The effect of the catechol-O-methyltransferase (COMT) Val158Met polymorphism on brain morphology has been investigated but remains controversial. We hypothesized that a comparison between Val/Val and Val/Met individuals, which may represent the most different combinations concerning the effects of the COMT genotype, may reveal new findings. We investigated the brain morphology using 3-Tesla magnetic resonance imaging in 27 Val/Val and 22 Val/Met individuals. Voxel-based morphometry revealed that the volumes of the bilateral caudate and posterior cingulate cortex were significantly smaller in Val/Val individuals than in Val/Met individuals [right caudate: false discovery rate (FDR)-corrected p = 0.048; left caudate: FDR-corrected p = 0.048; and bilateral posterior cingulate cortex: FDR-corrected p = 0.048]. This study demonstrates that interacting functional variants of COMT affect gray matter regional volumes in healthy subjects.
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kakeda
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Ide
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Katsuki
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Wakako
authors.initials: W
authors.lastname: Umene-Nakano
authors.affiliation: Department of Radiology, University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Rieko
authors.initials: R
authors.lastname: Watanabe
authors.affiliation: Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.affiliation: Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Yukunori
authors.initials: Y
authors.lastname: Korogi
mesh_terms: D000328:Adult; D000368:Aged; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002421:Caudate Nucleus / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D005189:False Positive Reactions; D005260:Female; D005838:Genotype; D066128:Gray Matter / Q000502:physiology; D006179:Gyrus Cinguli / Q000502:physiology*; D064368:Healthy Volunteers; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014633:Valine / Q000235:genetics; D055815:Young Adult
chemical_list: D008715:Methionine; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase; D014633:Valine; D004298:Dopamine