title: Flexible synthesis of polyfunctionalised 3-fluoropyrroles.
abstract: An efficient and selective approach for the synthesis of polyfunctionalised 3-fluoropyrroles has been developed starting from commercial aldehydes. The methodology is concise, efficient and allows for the modular and systematic assembly of polysubstituted 3-fluoropyrroles. This synthesis provides an alternative and highly convergent strategy for the generation of these chemically and biologically important units.
authors.affiliation: School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Cogswell
authors.affiliation: Oncology iMed, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
authors.forename: Craig S
authors.initials: CS
authors.lastname: Donald
authors.affiliation: School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK and Department of Chemistry, Xi'an Jiaotong-Liverpool University, SIP Suzhou, 215123, China. rudi.marquez@xjtlu.edu.cn.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Marquez
mesh_terms: D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006845:Hydrocarbons, Fluorinated; D011758:Pyrroles