title: B cells biology in systemic lupus erythematosus-from bench to bedside.
abstract: Systemic lupus erythematosus (SLE) is a debilitating autoimmune disease that can involve multi-organs. B cells play a central role in the immunopathogenesis via antibody-dependent and antibody-independent ways. Excessive autoantibodies production, hyperresponsiveness and prolonged survival of autoreactive B cells are characteristics of SLE. In this article, mechanisms of self-tolerance loss of B cells and promising B cell-targeting therapies in lupus are reviewed and discussed.
authors.affiliation: Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
authors.forename: LiDan
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
authors.forename: YanXia
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. zxpumch2003@sina.com.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D018448:Models, Immunological; D010950:Plasma Cells / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D057170:Translational Research, Biomedical / Q000379:methods*
chemical_list: D001323:Autoantibodies
keywords: B cell; pathogenesis; systemic lupus erythematosus; target therapy