title: [Correlation from Undiluted Vitreous Cytokines of Untreated Central Retinal Vein Occlusion with Spectral Domain Optical Coherence Tomography].
abstract: OBJECTIVE
  To correlate key inflammatory and pro-angiogenic cytokines from undiluted vitreous fluid of treatment-naïve patients with central retinal vein occlusion (CRVO) with SD-OCT parameters.
  
  
  METHODS
  Thirty-five patients (age 71.1 years, 24 phakic, 30 non-ischaemic) underwent intravitreal combination therapy, including single-site 23-gauge core vitrectomy. Twenty-eight samples from patients with idiopathic, non-uveitis floaterectomy served as controls. Levels of interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and vascular endothelial growth factor (VEGF-A) were correlated with visual acuity (logMar), category of CRVO (ischaemic or non-ischaemic) and morphological parameters, such as central macular thickness (CMT), thickness of neurosensory retina (Tneuro), extent of serous retinal detachment (SRT) and disintegrity of the IS/OS and others.
  
  
  RESULTS
  Mean IL-6 was 64.7 pg/ml (SD ± 115.8), mean MCP-1 1015.7 pg/ml (± 970.1), and mean VEGF-A 278.4 pg/ml (± 512.8), which was significantly higher than the control values of IL-6 6.2 ± 3.4 pg/ml (p = 0.06), MCP-1 253.2 ± 73.5 pg/ml (p < 0.0 000 001) and VEGF-A 7.0 ± 4.9 pg/ml (p < 0.0006), respectively. All cytokines correlated highly with one another (correlation coefficient r = 0.82 for IL-6 and MCP-1; r = 0.68 for Il-6 and VEGF-A; r = 0.64 for MCP-1 and VEGF-A). IL-6 correlated significantly with CMT, TRT, SRT, dIS/OS, and dELM. MCP-1 correlated significantly with SRT, dIS/OS, and dELM. VEGF-A did not correlate with changes in SD-OCT, while it had a trend to be higher in the ischaemic versus the non-ischaemic CRVO groups (p = 0.09).
  
  
  CONCLUSIONS
  The inflammatory cytokines were more often correlated with morphological changes assessed by SD-OCT, whereas VEGF-A did not correlate with CRVO-associated changes in SD-OCT. VEGF inhibition alone may not be sufficient to decrease the inflammatory response in CRVO therapy.
authors.affiliation: Augenklinik, Universität Heidelberg.
authors.forename: I
authors.initials: I
authors.lastname: Dacheva
authors.affiliation: Augenklinik, Universität Heidelberg.
authors.forename: K
authors.initials: K
authors.lastname: Ceglowska
authors.affiliation: Augenklinik, Universität Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Nobl
authors.affiliation: Department of General Ophthalmology, Medical University of Lublin, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Nowomiejska
authors.affiliation: Augenklinik, Universität Heidelberg.
authors.forename: F T
authors.initials: FT
authors.lastname: Kretz
authors.affiliation: Augenklinik, Universität Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Reich
authors.affiliation: Augenklinik, Universitätsklinikum Frankfurt.
authors.forename: S
authors.initials: S
authors.lastname: Deuchler
authors.affiliation: Augenklinik, Universität Heidelberg.
authors.forename: T
authors.initials: T
authors.lastname: Tandogan
authors.affiliation: Augenklinik, Universität Heidelberg.
authors.forename: G U
authors.initials: GU
authors.lastname: Auffarth
authors.affiliation: Augenklinik, Universität Heidelberg.
authors.forename: M J
authors.initials: MJ
authors.lastname: Koss
mesh_terms: D000368:Aged; D016207:Cytokines / Q000276:immunology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D018836:Inflammation Mediators / Q000276:immunology*; D008297:Male; D015203:Reproducibility of Results; D012170:Retinal Vein Occlusion / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology*; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D041623:Tomography, Optical Coherence / Q000379:methods*; D014822:Vitreous Body / Q000276:immunology*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators