title: Biological variations of thirteen plasma biochemical indicators.
abstract: BACKGROUND
  Reports on biological variation of plasma biochemical indicators are limited. We evaluated biological variations of 13 plasma biochemical indicators.
  
  
  METHODS
  Plasma samples were collected from 40 healthy individuals over 5days. Intra-individual coefficient of variation (CVI), inter-individual coefficient of variation (CVG), index of individuality (II), reference change value (RCV), and analytical goal parameters were calculated.
  
  
  RESULTS
  Albumin (Alb) showed the lowest CVI (2.50%) and the lowest CVG (5.08%), while C-reactive protein (hsCRP) presented the highest CVI (26.87%) and CVG (61.73%). II values were all less than 1.0. Alb presented the lowest 95% RCV (7.67), while hsCRP showed the highest 95% RCV (74.61). Alb, urea, creatinine (Cr), creatine kinase (CK), and creatine kinase isoenzyme MB (CKMBmass) CVI differed with gender (P<0.05). The CVG of the 13 indicators presented a significant gender difference (P<0.0001). Alb showed the lowest desirable imprecision CV (1.3%), the lowest desirable bias (1.4%), and the lowest desirable total error (3.5%), while hsCRP presented the highest desirable imprecision (13.4%), the highest desirable bias (16.8%), and the highest desirable total error (39.0%).
  
  
  CONCLUSIONS
  Our findings add to the database of biological variations of plasma indicators.
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Qi
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Basic Medicine Sciences, Chinese Academy of Medical Sciences School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China.
authors.forename: Xinming
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Shuling
authors.initials: S
authors.lastname: Chi
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address: wendycuiwei@sina.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003402:Creatine Kinase / Q000097:blood*; D003404:Creatinine / Q000097:blood*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014508:Urea / Q000097:blood*; D055815:Young Adult
chemical_list: D000418:Albumins; D015415:Biomarkers; D007527:Isoenzymes; D014508:Urea; D002097:C-Reactive Protein; D003404:Creatinine; D003402:Creatine Kinase
keywords: Analytical goal; Biological variation; Index of individuality; Plasma biochemical indicator; Reference change value