title: Early onset of nontuberculous mycobacterial pulmonary disease contributes to the lethal outcome in lung transplant recipients: report of two cases and review of the literature.
abstract: Lung transplant (LuTx) recipients represent a population at risk of nontuberculous mycobacterial pulmonary disease (NTM-PD). Yet the risk factors, the timing of NTM-PD after transplantation, and the association with allograft dysfunction all remain poorly defined. We report 2 cases of early-onset NTM-PD and review the literature, focusing on NTM-PD in LuTx recipients not colonized with NTM prior to transplantation. In addition, we summarize the main characteristics and differences between early- and late-onset disease.
authors.affiliation: Department for Lung Diseases, University Hospital Centre Zagreb, Zagreb, Croatia.|School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Jankovic Makek
authors.affiliation: Department for Lung Diseases, University Hospital Centre Zagreb, Zagreb, Croatia.|School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: G
authors.initials: G
authors.lastname: Pavlisa
authors.affiliation: Department for Lung Diseases, University Hospital Centre Zagreb, Zagreb, Croatia.|School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Jakopovic
authors.affiliation: Department for Lung Diseases, University Hospital Centre Zagreb, Zagreb, Croatia.
authors.forename: G
authors.initials: G
authors.lastname: Redzepi
authors.affiliation: National Reference Laboratory for Mycobacteria, National Institute of Health, Zagreb, Croatia.
authors.forename: L
authors.initials: L
authors.lastname: Zmak
authors.affiliation: Department for Lung Diseases, University Hospital Centre Zagreb, Zagreb, Croatia.
authors.forename: A
authors.initials: A
authors.lastname: Vukic Dugac
authors.affiliation: Department for Lung Diseases, University Hospital Centre Zagreb, Zagreb, Croatia.
authors.forename: A
authors.initials: A
authors.lastname: Hecimovic
authors.affiliation: School of Medicine, University of Zagreb, Zagreb, Croatia.|Department of Thoracic Radiology, University Hospital Centre Zagreb, Zagreb, Croatia.
authors.forename: I
authors.initials: I
authors.lastname: Mazuranic
authors.affiliation: Department of Surgery, Division of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Jaksch
authors.affiliation: Department of Surgery, Division of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Klepetko
authors.affiliation: Department for Lung Diseases, University Hospital Centre Zagreb, Zagreb, Croatia.|School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Samarzija
mesh_terms: D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008168:Lung / Q000382:microbiology; D008171:Lung Diseases / Q000175:diagnosis* / Q000382:microbiology; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000000981:diagnostic imaging* / Q000382:microbiology; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification*; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D066027:Transplant Recipients
keywords: lethal outcome; lung transplantation; nontuberculous mycobacteria; nontuberculous mycobacterial pulmonary disease