title: Bench to Bedside: From the Science to the Practice of Addiction Medicine.
abstract: The current understanding of addiction is based on a biopsychosocial model of illness. From a neurobiological perspective, addiction can be seen as the hijacking of the pleasure-reward pathways of the brain with a concomitant weakening of its executive function. The fundamental model has been expanded to include newer concepts such as multiple levels of severity of illness, motivational circuitry, and anti-reward pathways. These neurobiological concepts can explain some of the successes and failures of addiction treatment in the second half of the 20th century and the beginning of the 21st century. Psychosocial interventions (primarily cognitive behavior therapy, mutual help groups, and motivational interviewing) and pharmacological treatments (such as agonists, antagonists, and partial agonists) form the basis of addiction treatment today.
authors.affiliation: Department of Psychiatry, Rutgers New Jersey Medical School, Behavioral Health Sciences Building, Room F-1436, 183 South Orange Avenue, Newark, 07103, NJ, USA. PetrosLevounis@msn.com.
authors.forename: Petros
authors.identifier: http://orcid.org/0000-0002-5404-4610
authors.initials: P
authors.lastname: Levounis
mesh_terms: D000818:Animals; D016739:Behavior, Addictive; D006801:Humans; D008960:Models, Psychological; D011613:Psychotherapy / Q000379:methods; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D057170:Translational Research, Biomedical; D016896:Treatment Outcome
keywords: Addiction; Alcohol dependence; Opioid dependence; Toxicology