title: Chemical constituents of essential oil of endemic Rhanterium suaveolens Desf. growing in Algerian Sahara with antibiofilm, antioxidant and anticholinesterase activities.
abstract: Twenty compounds were detected in the essential oil of Rhanterium suaveolens representing 98.01% of the total oil content. Perillaldehyde (45.79%), caryophyllene oxide (24.82%) and β-cadinol (5.61%) were identified as the main constituents. In β-carotene-linoleic acid assay, both the oil and the methanol extract exhibited good lipid peroxidation inhibition activity, with IC50 values of 17.97 ± 5.40 and 11.55 ± 3.39 μg/mL, respectively. In DPPH and CUPRAC assays, however, the methanol extract exhibited a good antioxidant activity. The highest antibiofilm activity has been found 50.30% against Staphylococcus epidermidis (MU 30) at 20 μg/mL for essential oil and 58.34% against Micrococcus luteus (NRRL B-4375) at 25 mg/mL concentration for methanol extract. The in vitro anticholinesterase activity of methanol extract showed a moderate acetylcholinesterase inhibitory (IC50 = 168.76 ± 0.62 μg/mL) and good butyrylcholinesterase inhibitory (IC50 = 54.79 ± 1.89 μg/mL) activities. The essential oil was inactive against both enzymes.
authors.affiliation: a Faculty of Life and Natural Sciences, Department of Biology , El Oued University , El-Oued , Algeria.|b Laboratory of Biomolecules and Plant Breeding, Faculty of Exact Science and Life Science and Nature, Life Science and Nature Department , University of Larbi Ben Mhidi , Oum El Bouaghi , Algeria.
authors.forename: Ahmed Elkhalifa
authors.initials: AE
authors.lastname: Chemsa
authors.affiliation: c Faculty of Science, Department of Chemistry , Mugla Sitki Kocman University , Mugla , Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Erol
authors.affiliation: c Faculty of Science, Department of Chemistry , Mugla Sitki Kocman University , Mugla , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Öztürk
authors.affiliation: b Laboratory of Biomolecules and Plant Breeding, Faculty of Exact Science and Life Science and Nature, Life Science and Nature Department , University of Larbi Ben Mhidi , Oum El Bouaghi , Algeria.
authors.forename: Amar
authors.initials: A
authors.lastname: Zellagui
authors.affiliation: d Department of Plant and Animal Breeding, Ula Ali Kocman Vocational School , Mugla Sitki Kocman University , Mugla , Turkey.
authors.forename: Ceylan
authors.initials: C
authors.lastname: Özgür
authors.affiliation: b Laboratory of Biomolecules and Plant Breeding, Faculty of Exact Science and Life Science and Nature, Life Science and Nature Department , University of Larbi Ben Mhidi , Oum El Bouaghi , Algeria.
authors.forename: Noureddine
authors.initials: N
authors.lastname: Gherraf
authors.affiliation: c Faculty of Science, Department of Chemistry , Mugla Sitki Kocman University , Mugla , Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Duru
mesh_terms: D000352:Africa, Northern; D000462:Algeria; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D018441:Biofilms / Q000187:drug effects*; D001713:Biphenyl Compounds; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D000432:Methanol; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012997:Solvents; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D002800:Cholinesterase Inhibitors; D009822:Oils, Volatile; D010851:Picrates; D010936:Plant Extracts; D012997:Solvents; C004931:1,1-diphenyl-2-picrylhydrazyl; D000432:Methanol
keywords: Rhanterium suaveolens; antibiofilm; anticholinesterase; antioxidant activity; essential oil