title: Fertility Issues for Patients with Hypogonadotropic Causes of Delayed Puberty.
abstract: Delayed puberty presenting with low gonadotropins has multiple causes. Self-limited delay (constitutional delay) is generally considered benign, but adult height and bone mineral density may be compromised, and fertility has not been studied. Functional hypogonadotropic hypogonadism due to a stressor is thought to resolve with removal of the stressor, but reproductive endocrine dysfunction can sometimes persist. Most but not all patients with idiopathic hypogonadotropic hypogonadism, a typically long-lasting condition, can achieve fertility with exogenous hormone therapy. Future studies are needed to determine fertility outcomes in self-limited delayed puberty and to more clearly define prognostic factors for fertility in functional and idiopathic hypogonadotropic hypogonadism.
authors.affiliation: Division of Endocrinology, Department of Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Division of Endocrinology, Department of Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: Yee-Ming.Chan@childrens.harvard.edu.
authors.forename: Yee-Ming
authors.initials: YM
authors.lastname: Chan
mesh_terms: D006801:Humans; D007006:Hypogonadism / Q000150:complications / Q000628:therapy; D007246:Infertility / Q000188:drug therapy / Q000209:etiology; D011628:Puberty, Delayed / Q000188:drug therapy / Q000209:etiology
keywords: Bone mineral density; Delayed puberty; Fertility; Functional hypogonadotropic hypogonadism; Height; Hypothalamic amenorrhea; Idiopathic hypogonadotropic hypogonadism