title: The use of a collagen matrix in hard-to-heal venous leg ulcers.
abstract: OBJECTIVE
  The effects of a collagen dressing on hard-to-heal venous leg ulcers (vlUs) were evaluated in this prospective, randomised, controlled study.
  
  
  METHODS
  Patients with hard-to-heal vlU were included and divided into two groups using the block randomisation method. The first group was treated with a collagen and an alginate dressing (group A), and the second group with an alginate dressing alone (group b). both groups also had a short-stretch compression system applied at every dressing change. The dressings were changed twice a week for 12 weeks or until the ulcer was healed. Granulation tissue improvement, wound size, overall dressing performance and dressing comfort were evaluated and recorded.
  
  
  RESULTS
  A total of 40 patients completed the study evaluation period. Group A had a 65% increase in granulation tissue compared to 38% in group b. The mean ulcer area was reduced to 45% in group A compared to 20% in group b at 12 weeks. no significant side effects were detected in either group. Patients of both groups were satisfied with their treatment and healing progress.
  
  
  CONCLUSIONS
  The results of this study showed the effectiveness and safety of a collagen dressing in hard-to-heal vlUs as an adjunctive therapy with compression bandaging. These encouraging results may positively affect the quality of life of patients with chronic wounds.
authors.affiliation: Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Romanelli
authors.affiliation: University of California San Diego, California, US.
authors.forename: G
authors.initials: G
authors.lastname: Mulder
authors.affiliation: Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Paggi
authors.affiliation: Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Macchia
authors.affiliation: Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Panduri
authors.affiliation: Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Dini
mesh_terms: D000368:Aged; D001458:Bandages; D002908:Chronic Disease; D003094:Collagen; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000451:nursing / Q000628:therapy*; D008297:Male; D017592:Skin Care / Q000451:nursing; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D003094:Collagen
keywords: collagen; compression bandaging; granulation tissue; venous leg ulcer