title: Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits.
abstract: In this experimental study we have investigated whether the inclusion of the dietary fiber Plantago ovata husk could be recommended as coadjuvant in treatments with oral hypoglycemic drugs. We evaluated the use of Plantago ovata husk-metformin association in diabetic rabbits by determining its effects on glucose and insulin concentrations. Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). Two groups (numbers 1 and 4) were used as controls (receiving standard or supplemented chow), two groups (numbers 2 and 5) received metformin orally, and the other two (numbers 3 and 6) were treated orally with metformin and psyllium. Plasma glucose concentrations were lower in groups fed with fiber-supplemented chow whereas insulin levels showed important interindividual variations. Glucose pharmacokinetics parameters showed significant differences in Cmax and t(max) in relation to fiber intake. Insulin pharmacokinetics parameters after treatment with oral metformin showed an important increase in Cmax, AUC, and t(max) in animals fed with fiber. We conclude that Plantago ovata husk intake can contribute to the oral antihyperglycemic treatment of type 2 diabetes.
authors.affiliation: Pharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Díez-Láiz
authors.affiliation: Pharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: García-Vieitez
authors.affiliation: Pharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.
authors.forename: M José
authors.initials: MJ
authors.lastname: Diez-Liébana
authors.affiliation: Pharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.
authors.forename: Matilde
authors.initials: M
authors.lastname: Sierra-Vega
authors.affiliation: Pharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sahagún-Prieto
authors.affiliation: Pharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.
authors.forename: Ángela P
authors.initials: ÁP
authors.lastname: Calle-Pardo
authors.affiliation: Pharmacology, Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.
authors.forename: Nélida
authors.initials: N
authors.lastname: Fernández-Martínez
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004043:Dietary Fiber; D004359:Drug Therapy, Combination; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D008687:Metformin / Q000627:therapeutic use*; D008517:Phytotherapy; D010943:Plantago; D011817:Rabbits; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin