title: Human papillomavirus and its clinical relevance in oesophageal squamous cell carcinoma in a Kurdish population in the west of Iran.
abstract: Background The aetiological role of Human Papillomavirus (HPV) in oesophageal squamous cell carcinoma (ESCC) was evaluated by assessment of the presence and status of HPV DNA in a Kurdish population in the west of Iran. Methods One hundred and three paraffin-embedded ESCC tissue samples, diagnosed between 2007-2013, were included in the study. DNA was extracted and then HPV presence and genotypes were determined by PCR and INNO-LiPA genotyping, respectively. Results HPV DNA was detected in 11/103 (10.7%) of ESCCs. HPV-18 and HPV-16 genotypes were determined in five and six samples, respectively. Co-infection of HPV-6 was only found with HPV-18 in two cases. There were no statistically significant distinctions between HPV-positive and HPV-negative cases with regard to clinical and pathologic findings. Conclusion The present study indicates that, among a group of Kurdish people in two provinces in the west of Iran, as a low-risk ESCC area, HPV could be one of the risk factors, although in a small proportion of the patients.
authors.affiliation: a Cellular and Molecular Research Center, Kurdistan University of Medical Sciences , Sanandaj , Iran.|b Departments of Marine Biology , Faculty of Marine Sciences, Chabahar Maritime University , Chabahar , Iran.
authors.forename: Fariborz
authors.initials: F
authors.lastname: Soheili
authors.affiliation: b Departments of Marine Biology , Faculty of Marine Sciences, Chabahar Maritime University , Chabahar , Iran.
authors.forename: Nilofar
authors.initials: N
authors.lastname: Heidary
authors.affiliation: c Department of Pathology , Kermanshah University of Medical Sciences , Kermanshah , Iran.
authors.forename: Mahtab
authors.initials: M
authors.lastname: Rahbar
authors.affiliation: a Cellular and Molecular Research Center, Kurdistan University of Medical Sciences , Sanandaj , Iran.
authors.forename: Bahram
authors.initials: B
authors.lastname: Nikkho
authors.affiliation: d Department of Oncology-Pathology , Karolinska Institute, Karolinska University Hospital , Stockholm , Sweden.
authors.forename: Omid
authors.initials: O
authors.lastname: Fotouhi
authors.affiliation: e Department of Community Medicine & Kurdistan Research Center for Social Determinants of Health , Kurdistan University of Medical Sciences , Sanandej , Iran.
authors.forename: Abdolrahim
authors.initials: A
authors.lastname: Afkhamzadeh
authors.affiliation: f Departments of Statistic and Basic Science , Chabahar Maritime University , Chabahar , Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Jafari
authors.affiliation: g Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences , Rafsanjan , Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Bagheri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology / Q000821:virology*; D060085:Coinfection / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology / Q000821:virology*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology / Q000821:virology*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D004279:DNA, Viral
keywords: ESCC; HPV; Kurdish population; oesophageal squamous cell carcinoma