title: AMPD1 polymorphism and response to regadenoson.
abstract: OBJECTIVE
  AMPD1 c.34C > T (rs17602729) polymorphism results in AMPD1 deficiency. We examined the association of AMPD1 deficiency and variability of hemodynamic response to regadenoson.
  
  
  METHODS
  Genotyping for c.34C>T was performed in 267 patients undergoing regadenoson cardiac stress testing.
  
  
  RESULTS
  Carriers of c.34C >T variant exhibited higher relative changes in systolic blood pressure (SBP) compared with wild-type subjects ([%] SBP change to peak: 12 ± 25 vs 5 ± 13%; p = 0.01) ([%] SBP change to nadir: -3 ± 15 vs -7 ± 11%; p = 0.04). Change in heart rate was similar between groups, but side effects were more common in carriers of the variant (+LR = 4.2; p = 0.04).
  
  
  CONCLUSIONS
  AMPD1 deficiency may be involved in the modulation of regadenoson's systemic effects.
authors.affiliation: Department of Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 N. Capitol Ave, MPC2, ME-400, Indianapolis, IN 46202, USA.
authors.forename: Rayan
authors.initials: R
authors.lastname: Saab
authors.affiliation: Department of Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 N. Capitol Ave, MPC2, ME-400, Indianapolis, IN 46202, USA.
authors.forename: Aline N
authors.initials: AN
authors.lastname: Zouk
authors.affiliation: Department of Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 N. Capitol Ave, MPC2, ME-400, Indianapolis, IN 46202, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Mastouri
authors.affiliation: Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Clinical Pharmacology Research Institute (R2), Room 402, 950 West Walnut Street, Indianapolis, IN 46202, USA.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Skaar
authors.affiliation: Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Clinical Pharmacology Research Institute (R2), Room 402, 950 West Walnut Street, Indianapolis, IN 46202, USA.
authors.forename: Santosh
authors.initials: S
authors.lastname: Philips
authors.affiliation: Department of Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 N. Capitol Ave, MPC2, ME-400, Indianapolis, IN 46202, USA.|Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Clinical Pharmacology Research Institute (R2), Room 402, 950 West Walnut Street, Indianapolis, IN 46202, USA.
authors.forename: Rolf P
authors.initials: RP
authors.lastname: Kreutz
mesh_terms: D000659:AMP Deaminase / Q000172:deficiency* / Q000235:genetics*; D058908:Adenosine A2 Receptor Agonists / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics*; D005080:Exercise Test / Q000187:drug effects / Q000379:methods; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011687:Purines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*
chemical_list: D058908:Adenosine A2 Receptor Agonists; D011687:Purines; D011720:Pyrazoles; C430916:regadenoson; D000659:AMP Deaminase; C514117:AMPD1 protein, human
keywords: adenosine; genetic; myocardial perfusion imaging; regadenoson