title: Classification of Unsteady Flow Patterns in a Rotodynamic Blood Pump: Introduction of Non-Dimensional Regime Map.
abstract: Rotodynamic blood pumps (also known as rotary or continuous flow blood pumps) are commonly evaluated in vitro under steady flow conditions. However, when these devices are used clinically as ventricular assist devices (VADs), the flow is pulsatile due to the contribution of the native heart. This study investigated the influence of this unsteady flow upon the internal hemodynamics of a centrifugal blood pump. The flow field within the median axial plane of the flow path was visualized with particle image velocimetry (PIV) using a transparent replica of the Levacor VAD. The replica was inserted in a dynamic cardiovascular simulator that synchronized the image acquisition to the cardiac cycle. As compared to steady flow, pulsatile conditions produced periodic, transient recirculation regions within the impeller and separation in the outlet diffuser. Dimensional analysis revealed that the flow characteristics could be uniquely described by the non-dimensional flow coefficient (Φ) and its time derivative ([Formula: see text]), thereby eliminating impeller speed from the experimental matrix. Four regimes within the Φ-[Formula: see text] plane were found to classify the flow patterns, well-attached or disturbed. These results and methods can be generalized to provide insights for both design and operation of rotodynamic blood pumps for safety and efficacy.
authors.affiliation: Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Drive, Pittsburgh, PA, 15219, USA. fangjun@gmail.com.|Department of Mechanical and Aerospace Engineering, New Mexico State University, Las Cruces, NM, 88003, USA. fangjun@gmail.com.
authors.forename: Fangjun
authors.initials: F
authors.lastname: Shu
authors.affiliation: Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Drive, Pittsburgh, PA, 15219, USA.|ARTORG Center for Biomedical Research, University of Bern, Bern, Switzerland.
authors.forename: Stijn
authors.initials: S
authors.lastname: Vandenberghe
authors.affiliation: Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Drive, Pittsburgh, PA, 15219, USA.
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Brackett
authors.affiliation: Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Drive, Pittsburgh, PA, 15219, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Antaki
mesh_terms: D001783:Blood Flow Velocity; D002498:Centrifugation / Q000295:instrumentation; D004867:Equipment Design; D006339:Heart Rate; D006353:Heart-Assist Devices; D006439:Hemodynamics; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D012212:Rheology; D016276:Ventricular Function
keywords: Continuous flow; Flow coefficient; Particle image velocimetry (PIV); Pulsatile flow; Regime map; Rotodynamic pumps; Ventricular assist devices (VAD)