title: MGL induces nuclear translocation of EndoG and AIF in caspase-independent T cell death.
abstract: Macrophage galactose-type lectin (MGL) participates in the regulation of T cell apoptosis, but the exact death pathway remains unclear. Here, we demonstrated that MGL-induced T cell death occurs in a caspase-independent manner. Furthermore, MGL treatment triggers the translocation of endonuclease G (EndoG) and apoptosis-inducing factor (AIF) from the mitochondria to the nucleus. Because galectin-1 (Gal-1) can also initiate similar mitochondrial events, we speculate that this death pathway may be widely used by the lectin family.
authors.forename: Qingpan
authors.initials: Q
authors.lastname: Bu
authors.forename: Jianhui
authors.initials: J
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zheng
authors.forename: Yingying
authors.initials: Y
authors.lastname: Zou
authors.forename: Min
authors.initials: M
authors.lastname: Wei
mesh_terms: D017209:Apoptosis; D051033:Apoptosis Inducing Factor / Q000378:metabolism*; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D004706:Endodeoxyribonucleases / Q000378:metabolism*; D006801:Humans; D019169:Jurkat Cells; D037181:Lectins, C-Type / Q000235:genetics / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
chemical_list: D051033:Apoptosis Inducing Factor; D037181:Lectins, C-Type; C506225:MGL lectin, human; D011948:Receptors, Antigen, T-Cell; D004706:Endodeoxyribonucleases; C052391:endonuclease G; D020169:Caspases