title: NGA- A Novel Hypothetical Drug Model: Combinatorial Approach to Multifactorial Alzheimer's Disease.
abstract: Alzheimer's disease (AD) is supposed to stanch from inappropriate waving in the brain sections related to memory and perception. The incidence of AD in distressed person associated with an upsurge in the accumulation of amyloid plaque-rich senile plaques and neurofibrillary tangles in the brain. We hypothesize that a combination therapy provides a new treatment for AD. We propose that an anti-AD drug, NGA, a combination of NSAIDS, Galanthamine and ACS-40 may be useful in preventing the formation of amyloid plaques from β-amyloid. Being a widespread incurable disease, the treatment for Alzheimer's has been at the forefront of the medical research work. We propose a novel drug-like NGA will allow for the effective control and treatment of the progression of AD by preventing acetylcholinesterase activity and reducing plaque formation that forms the distinctive symptom for the identification of the onset of AD. A combinatory use of NSAID with a natural neurotransmitter will allow for an efficient control of amyloid beta toxicity and will open doors for the treatment of a myriad of other neurodegenerative diseases.
authors.affiliation: School of Biosciences and Technology, VIT University, Vellore- 632014, Tamil Nadu, India. subaresearch@rediffmail.com.
authors.forename: C Subathra
authors.initials: CS
authors.lastname: Devi
authors.forename: V
authors.initials: V
authors.lastname: Mohanasrinivasan
authors.forename: C George
authors.initials: CG
authors.lastname: Priyadoss
authors.forename: Nikhil
authors.initials: N
authors.lastname: Arora
authors.forename: Bharti
authors.initials: B
authors.lastname: Singh
authors.forename: Neetu
authors.initials: N
authors.lastname: Mittal
authors.forename: Shubham
authors.initials: S
authors.lastname: Agarwal
authors.forename: Shwetank
authors.initials: S
authors.lastname: Saxena
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D004220:Disulfides / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D005702:Galantamine / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007980:Levodopa / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D058225:Plaque, Amyloid / Q000188:drug therapy
chemical_list: C583845:ACS 84; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002800:Cholinesterase Inhibitors; D004220:Disulfides; D004338:Drug Combinations; D005702:Galantamine; D007980:Levodopa