title: Hyperbaric index in the primary prevention of hypertensive complications in high-risk pregnancy.
abstract: BACKGROUND
  Preeclampsia (PE) is a major cause of fetal morbidity and mortality. In the Western World, PE affects 2-7% of pregnancies and is responsible for 50,000 deaths annually. Early detection is a priority as it can change the clinical course, but there are no biomarkers or instrumental methods with high sensitivity and specificity. Only the hyperbaric index has a sensitivity and specificity of 99% for early identification of pregnant women at risk of developing PE, but its use is not widespread.
  
  
  OBJECTIVE
  To assess the usefulness of the hyperbaric index in the primary prevention of hypertensive pregnancy complications in a public healthcare area.
  
  
  METHODS
  This is a retrospective study of pregnancies that occurred in our area during the period 2007-2012 (N=11,784). The diagnosis was established by the hyperbaric index and pregnant women at risk were treated with ASA at night.
  
  
  RESULTS
  In pregnant patients referred to the nephrology clinic (38.2%), diagnosed as high-risk for PE, and treated with 100mg ASA/night (from week 17), the incidence of PE episodes was reduced by 96.94.
authors.affiliation: Servicio de Nefrología, Centro Hospitalario Universitario de Ourense, Ourense, España. Electronic address: alfonso.otero.gonzalez@sergas.es.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Otero González
authors.affiliation: Servicio de Nefrología, Centro Hospitalario Universitario de Ourense, Ourense, España.
authors.forename: Silvia
authors.initials: S
authors.lastname: Uribe Moya
authors.affiliation: Servicio de Nefrología, Centro Hospitalario Universitario de Ourense, Ourense, España.
authors.forename: Ivan Gilberto
authors.initials: IG
authors.lastname: Arenas Moncaleano
authors.affiliation: Servicio de Nefrología, Centro Hospitalario Universitario de Ourense, Ourense, España.
authors.forename: María Paz
authors.initials: MP
authors.lastname: Borrajo Prol
authors.affiliation: Servicio de Nefrología, Centro Hospitalario Universitario de Ourense, Ourense, España.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: García García
authors.affiliation: Documentación Clínica, Centro Hospitalario Universitario de Ourense, Ourense, España.
authors.forename: Luis
authors.initials: L
authors.lastname: López Sánchez
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D004334:Drug Administration Schedule; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk / Q000502:physiology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: Embarazo; Hipertensión; Hyperbaric index; Hypertension; Pregnancy; Índice hiperbárico