title: Do cytostatic drugs reach drinking water? The case of mycophenolic acid.
abstract: Mycophenolic acid (MPA) has been identified as a new river contaminant according to its wide use and high predicted concentration. The aim of this study was to monitor the impact of MPA in a drinking water treatment plant (DWTP) that collects water downstream Llobregat River (NE Spain) in a highly densified urban area. During a one week survey MPA was recurrently detected in the DWTP intake (17-56.2 ng L(-1)). The presence of this compound in river water was associated to its widespread consumption (>2 tons in 2012 in Catalonia), high excretion rates and low degradability. The fate of MPA in waters at each treatment step of the DWTP was analyzed and complete removal was observed after pretreatment with chlorine dioxide. So far, MPA has not been described as water contaminant and its presence associated with its consumption in anticancer treatments is of relevance to highlight the importance of monitoring this compound.
authors.affiliation: Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 Barcelona, Catalonia, Spain.
authors.forename: Helena
authors.initials: H
authors.lastname: Franquet-Griell
authors.affiliation: Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 Barcelona, Catalonia, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Ventura
authors.affiliation: Aigües de Barcelona, S.A. General Batet 5-7, 08028 Barcelona, Catalonia, Spain.
authors.forename: M Rosa
authors.initials: MR
authors.lastname: Boleda
authors.affiliation: Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 Barcelona, Catalonia, Spain. Electronic address: slbqam@cid.csic.es.
authors.forename: Silvia
authors.initials: S
authors.lastname: Lacorte
mesh_terms: D054697:Cytostatic Agents / Q000032:analysis*; D060766:Drinking Water / Q000737:chemistry*; D004784:Environmental Monitoring; D009173:Mycophenolic Acid / Q000032:analysis; D045483:Rivers / Q000737:chemistry; D013030:Spain; D014874:Water Pollutants, Chemical / Q000032:analysis*; D014876:Water Pollution / Q000706:statistics & numerical data; D018508:Water Purification
chemical_list: D054697:Cytostatic Agents; D060766:Drinking Water; D014874:Water Pollutants, Chemical; D009173:Mycophenolic Acid
keywords: Drinking water; Liquid chromatography; Mycophenolic acid; River water; Tandem mass spectrometry