title: Presurgical navigated TMS motor cortex mapping improves outcome in glioblastoma surgery: a controlled observational study.
abstract: The authors report on an observational study designed to isolate the impact of navigated transcranial magnetic stimulation (nTMS) on surgical outcome in glioblastoma treatment. We undertook a controlled observational study to identify the additive impact of presurgical nTMS in patients scheduled for surgical treatment of glioblastoma in or near motor eloquent locations. The trial data is derived from a large university hospital with a differential availability of its nTMS mapping service at its two campuses, both equally served by a single neurosurgical department. When available, the nTMS cortical mapping data and nTMS-based fiber tractography are used for surgical planning and patient counseling as well as intraoperative identification of the primary motor cortex and guidance in subcortical motor mapping. The addition of preoperative nTMS mapping data to a clinical routine already incorporating preoperative fiber tractography and intraoperative neuronavigation and electrophysiology was shown to improve surgical outcomes by increasing the extent of resection, without compromising patient safety or long-term functional outcomes in comparison to the concurrent non-TMS control group. This study is the first to prove that the improved surgical outcomes observed in previous studies after the implementation of nTMS to presurgical work-up are not caused by any overall improvement in patient care or a paradigm shift toward more aggressive resection but by the additional functional data provided by nTMS.
authors.affiliation: Department of Neurosurgery, Charité, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. thomas.picht@charite.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Picht
authors.affiliation: Department of Neurosurgery, Charité, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
authors.forename: Dietmar
authors.initials: D
authors.lastname: Frey
authors.affiliation: Department of Radiology, Charité, Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Thieme
authors.affiliation: Department of Radiology, Charité, Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kliesch
authors.affiliation: Department of Neurosurgery, Charité, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Vajkoczy
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D038361:Neuronavigation / Q000379:methods*; D011300:Preoperative Care; D011379:Prognosis; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult
keywords: Glioblastoma; Intraoperative mapping; Motor eloquent cortex; Navigated transcranial magnetic stimulation; Surgical outcome