title: Study on encapsulation of chlorine dioxide in gelatin microsphere for reducing release rate.
abstract: OBJECTIVE
  This study aims to explore the effects of encapsulation of chlorine dioxide in a hydrophilic biodegradable polymer gelatin to reduce its release rate.
  
  
  METHODS
  An emulsification-coacervation method was adopted. The characterizations of chlorine dioxide-gelatin microspheres were described. Using UV-vis spectrophotometer the λmax of chlorine dioxide was observed at 358 nm. The particle size and distribution of chlorine oxide-gelatin microspheres was measured by a dynamic light scattering (DLS) method, the diameter was (1400~1900) nm. The entrapment of chlorine dioxide-gelatin microspheres was confirmed by IR. The surface morphology, size, and shape of chlorine dioxide-gelatin microspheres were analyzed using Scanning electron microscope (SEM).
  
  
  RESULTS
  It showed that the encapsulated microspheres size was around 2000 nm with uniform distribution. The percentage entrapment of chlorine dioxide in the encapsulated samples was about 80~85%. A slow release study of chlorine dioxide from the encapsulated biopolymer (gelatin) in air was also carried out, which showed continuous release up to ten days.
  
  
  CONCLUSIONS
  It can be concluded that it is possible to make a slow release formulation of ClO2 by entrapped in a hydrophilic biodegradable polymer gelatin. ClO2-gelatin microspheres can stable release low concentration ClO2 gas over an extended period.
authors.affiliation: Chinese Academy of Inspection and Quarantine Beijing 100176, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ci
authors.affiliation: Chinese Academy of Inspection and Quarantine Beijing 100176, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Technical Institute of Physics and Chemistry, CAS Beijing 100190, China.
authors.forename: Yanchuan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Nan Yang Normal University Nanyang 473061, Henan, China.
authors.forename: Ruixue
authors.initials: R
authors.lastname: Sun
authors.affiliation: Technical Institute of Physics and Chemistry, CAS Beijing 100190, China.
authors.forename: Xijie
authors.initials: X
authors.lastname: Wang
authors.affiliation: Chinese Academy of Inspection and Quarantine Beijing 100176, China.
authors.forename: Jinyou
authors.initials: J
authors.lastname: Li
keywords: Chlorine dioxide; encapsulation; gelatin; microsphere; release rate