title: Arterial and venous thromboembolism in chronic obstructive pulmonary disease: from pathogenic mechanisms to prevention and treatment.
abstract: Chronic obstructive pulmonary disease (COPD) affects approximately 10% of adults older than 40 years and is an important causes of disability and death in elderly subjects. A large proportion of COPD patients suffer from cardiovascular comorbidities. Thromboembolic events contribute considerably to morbidity and mortality in these subjects. This review summarizes the current evidence regarding the association of COPD with increased thromboembolic risk. We discuss multiple mechanisms potentially linking these conditions and available pharmacological interventions reducing the risk of thrombotic arterial and venous events with special attention paid to new oral anticoagulants.
authors.forename: Filip
authors.initials: F
authors.lastname: Mejza
authors.forename: Bernd
authors.initials: B
authors.lastname: Lamprecht
authors.forename: Ewa
authors.initials: E
authors.lastname: Niżankowska-Mogilnicka
authors.affiliation: II Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland. mmundas@cyf-kr.edu.pl.
authors.forename: Anetta
authors.initials: A
authors.lastname: Undas
mesh_terms: D015984:Causality; D015897:Comorbidity; D006801:Humans; D010353:Patient Education as Topic / Q000706:statistics & numerical data; D011322:Primary Prevention / Q000706:statistics & numerical data*; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000517:prevention & control*; D013923:Thromboembolism / Q000453:epidemiology* / Q000517:prevention & control*; D054556:Venous Thromboembolism / Q000453:epidemiology / Q000517:prevention & control
keywords: COPD; anticoagulants; cardiovascular; coagulation; thrombosis