title: Glioblastoma with Rhabdoid Features: Report of Two Young Adult Cases and Review of the Literature.
abstract: BACKGROUND
  There are few previous reports of glioblastoma in young adults, in particular, of the very rare recently proposed rhabdoid or epithelioid types.
  
  
  METHODS
  We report 2 cases of glioblastoma with rhabdoid features involving a 27-year-old woman and a 41-year-old man. In case 1, the patient presented with generalized seizures, and the initial magnetic resonance imaging showed a very small region of contrast in the left parahippocampal area. After 1 year, the mass suddenly increased in size. Treatment with multiple therapies was administered, but 5 months later, the patient died from multiple systemic metastases. In case 2, the patient presented with a chief complaint of headache for a few weeks. Computed tomography and magnetic resonance imaging showed a left parietal mass with calcification and meningeal dissemination. After undergoing surgical removal, his condition rapidly deteriorated until brain death occurred.
  
  
  CONCLUSIONS
  Glioblastoma with rhabdoid features may represent a specific pattern of clinical progression that emerges from histologic glioblastoma types.
authors.affiliation: Department of Neurosurgery, National Center for Global Health and Medicine, Tokyo, Japan; Advanced and Specialized Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: mmiyahara@hosp.ncgm.go.jp.
authors.forename: Makiko
authors.initials: M
authors.lastname: Miyahara
authors.affiliation: Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Sumihito
authors.initials: S
authors.lastname: Nobusawa
authors.affiliation: Department of Neurosurgery, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Department of Neurosurgery, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Kouichiro
authors.initials: K
authors.lastname: Okamoto
authors.affiliation: Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Mochizuki
authors.affiliation: Department of Neurosurgery, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hara
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D005909:Glioblastoma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D018335:Rhabdoid Tumor / Q000473:pathology*
keywords: Composite extrarenal rhabdoid tumors; Epithelioid glioblastoma; Multiple systemic metastases; Rhabdoid glioblastoma