title: The First Case of Invasive Mixed-Mold Infections Due to Emericella nidulans var. echinulata and Rasamsonia piperina in a Patient with Chronic Granulomatous Disease.
abstract: A 16-year-old boy with chronic granulomatous disease presented with pneumonia and rib osteomyelitis. Emericella nidulans var. echinulata was isolated from his sputum. After starting voriconazole, Rasamsonia piperina was isolated from the rib swelling. A combination therapy of voriconazole and micafungin effectively eradicated this invasive mixed-mold infection. In immunocompromised patients, a precise pathogenic diagnosis is clinically useful for administration of an appropriate treatment regimen.
authors.affiliation: Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan. ishiwada@faculty.chiba-u.jp.
authors.forename: Naruhiko
authors.initials: N
authors.lastname: Ishiwada
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takeshita
authors.affiliation: Division of Bioresources, Medical Mycology Research Center, Chiba University, Chiba, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yaguchi
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Koo
authors.initials: K
authors.lastname: Nagasawa
authors.affiliation: Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Takeuchi
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Hishiki
authors.affiliation: Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Watanabe
authors.affiliation: Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kamei
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Shimojo
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D001203:Ascomycota / Q000187:drug effects* / Q000302:isolation & purification; D060085:Coinfection / Q000188:drug therapy; D054714:Echinocandins / Q000627:therapeutic use*; D032842:Emericella / Q000187:drug effects* / Q000302:isolation & purification; D006105:Granulomatous Disease, Chronic / Q000382:microbiology*; D006801:Humans; D016867:Immunocompromised Host; D055666:Lipopeptides / Q000627:therapeutic use*; D008297:Male; D000077551:Micafungin; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology*; D013183:Sputum / Q000382:microbiology; D065819:Voriconazole / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D065819:Voriconazole; D000077551:Micafungin
keywords: Chronic granulomatous disease; Emericella nidulans var. echinulata; Micafungin; Rasamsonia piperina; Voriconazole