title: Q-Switched 660-nm Versus 532-nm Nd: YAG Laser for the Treatment for Facial Lentigines in Asian Patients: A Prospective, Randomized, Double-Blinded, Split-Face Comparison Pilot Study.
abstract: BACKGROUND
  Q-switched (QS) 532-nm lasers are widely used to treat solar lentigines.
  
  
  OBJECTIVE
  To compare the efficacy and safety of 660-nm and 532-nm QS neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers in the treatment for lentigines in Asians.
  
  
  METHODS
  The halves of each face (randomly chosen) of 8 Korean Fitzpatrick Skin Type III-IV women with facial solar lentigines were treated with either 660-nm or 532-nm lasers. Pigmentation was measured objectively using a profilometric skin analysis tool and subjectively using the pigmentation area and severity index (PSI) score, global assessment of the aesthetic improvement scale (GAIS), and a patient satisfaction score at Weeks 4 and 8.
  
  
  RESULTS
  Seven patients completed the study. No significant differences were found in the PSI, GAIS, patient satisfaction score, and melanin average score between the lasers. The melanin average level was significantly reduced by the 660-nm laser but not the 532-nm laser at Week 8 compared with the baseline.
  
  
  CONCLUSIONS
  Both 660-nm and 532-nm QS Nd:YAG lasers effectively reduce pigmentation for up to 8 weeks with high patient satisfaction. The new 660-nm laser therefore increases the treatment options for lentigines in Asian skin.
authors.affiliation: *Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; †Department of Dermatology, College of Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea; ‡S&U Dermatologic Clinic, Seoul, Korea; §Skidmore College, New York, New York.
authors.forename: Tai Kyung
authors.initials: TK
authors.lastname: Noh
authors.forename: Bo Young
authors.initials: BY
authors.lastname: Chung
authors.forename: Un Cheol
authors.initials: UC
authors.lastname: Yeo
authors.forename: SeoYoun
authors.initials: S
authors.lastname: Chang
authors.forename: Mi Woo
authors.initials: MW
authors.lastname: Lee
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Chang
mesh_terms: D000328:Adult; D044466:Asian People; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000009:adverse effects / Q000627:therapeutic use*; D007911:Lentigo / Q000208:ethnology* / Q000532:radiotherapy*; D028022:Low-Level Light Therapy / Q000009:adverse effects; D008875:Middle Aged; D017060:Patient Satisfaction; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome