title: Structural connectivity in a paediatric case of anarchic hand syndrome.
abstract: BACKGROUND
  "Anarchic hand" is a rare condition characterised by non-volitional, goal-directed movements of one arm. We report a case with analysis of structural and functional connectivity.
  
  
  METHODS
  A 15 year old girl developed intermittent symptoms of intermanual conflict or anarchic hand as a result of traumatic brain injury during which she sustained a callosal bleed. Resting-state fMRI and DTI tractography were performed at a stage when symptoms had largely resolved.
  
  
  CONCLUSIONS
  Structural connectivity between homologous superior frontal areas and functional connectivity between homologous posterior cingulate areas were significantly reduced, which may have contributed to causation. Tractography demonstrated new indirect connections between supplementary motor areas via the cerebellum, which we propose contributed to symptom resolution.
authors.affiliation: Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
authors.forename: Anna P
authors.initials: AP
authors.lastname: Basu
authors.affiliation: School of Computing Science, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
authors.forename: Peter Neal
authors.initials: PN
authors.lastname: Taylor
authors.affiliation: Institute of Cellular Medicine and Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
authors.forename: Eva
authors.initials: E
authors.lastname: Lowther
authors.affiliation: Magdalene College, University of Cambridge, Cambridge, CB3 0AG, UK.
authors.forename: Elizabeth O
authors.initials: EO
authors.lastname: Forsyth
authors.affiliation: Institute of Cellular Medicine and Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Blamire
authors.affiliation: Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. rob.forsyth@newcastle.ac.uk.|Institute of Neuroscience, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK. rob.forsyth@newcastle.ac.uk.
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Forsyth
mesh_terms: D000293:Adolescent; D055964:Alien Limb Phenomenon / Q000209:etiology*; D056324:Diffusion Tensor Imaging; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006179:Gyrus Cinguli / Q000473:pathology*; D016489:Head Injuries, Closed / Q000150:complications*; D006406:Hematoma / Q000150:complications; D006801:Humans; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000473:pathology