title: Recent Changes in the Incidence of Bronchopulmonary Dysplasia among Very-Low-Birth-Weight Infants in Korea.
abstract: We investigated the incidence of bronchopulmonary dysplasia (BPD) in very-low-birth-weight (VLBW) infants in Korea using the Korean Neonatal Network (KNN) data. In total, 2,386 VLBW infants born from January 2013 to June 2014 were prospectively registered. BPD was defined as supplemental oxygen or positive pressure support at 36 weeks postmenstrual age (PMA). The overall incidence of BPD was 28.9%, and the overall mortality rate in the neonatal intensive care units (NICUs) was 11.9%. To investigate recent changes in the incidence of BPD among VLBW infants, we compared the BPD rate in the present study with the latest nationwide retrospective survey conducted between 2007 and 2008. For comparison, we selected infants (23-31 weeks of gestation) (n=1,990) to adjust for the same conditions with the previous survey in 2007-2008 (n=3,841). Among the limited data on VLBW infants (23-31 weeks of gestation), the incidence of BPD increased by 85% (from 17.8% to 33.0%) and the mortality rate in the NICU decreased by 31.4% (from 18.8% to 12.9%) compared to those in the study conducted in 2007-2008. The current trend of increase in the incidence of BPD among infants can be attributed to the increase in the survival rate of VLBW infants.
authors.affiliation: Department of Pediatrics, CHA University, Seongnam, Korea.
authors.forename: Heui Seung
authors.initials: HS
authors.lastname: Jo
authors.affiliation: Department of Pediatrics, CHA University, Seongnam, Korea.
authors.forename: Kee Hyun
authors.initials: KH
authors.lastname: Cho
authors.affiliation: Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea.
authors.forename: Sung-Il
authors.initials: SI
authors.lastname: Cho
authors.affiliation: Department of Pediatrics, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Eun Song
authors.initials: ES
authors.lastname: Song
authors.affiliation: Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Beyong Il
authors.initials: BI
authors.lastname: Kim
mesh_terms: D001034:Apgar Score; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology* / Q000401:mortality; D016208:Databases, Factual; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal; D008297:Male; D016017:Odds Ratio; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
keywords: Bronchopulmonary Dysplasia; Incidence; Infant, Very-Low-Birth-Weight; Risk Factors; Treatment Outcome