title: Biotin-mediated epigenetic modifications: Potential defense against the carcinogenicity of benzo[a]pyrene.
abstract: Environmental pollution and an unhealthy lifestyle result in direct exposure to dangerous chemicals that can modify endogenous pathways and induce malignant transformation of human cells. Although the molecular mechanisms of tumorigenesis are still not well understood, epigenetic alteration may be associated with exogenous chemical-induced carcinogenicity. Given the association between nutrition and cancer, nutrient supplementation may reduce aberrant epigenetic modifications induced by chemicals, thus decreasing carcinogenesis. This paper provides an overview of the epigenetic events caused by benzo[a]pyrene, a procarcinogenic and environmental pollutant, and biotin, an essential water-soluble vitamin, and investigates potential connections between them. This paper also discusses the potential inhibitory effect of biotin-related epigenetic modifications on the carcinogenicity of benzo[a]pyrene. The effect of nutritional supplementation on tumorigenesis involving epigenetic modifications is also discussed.
authors.affiliation: Key Laboratory of Modern Toxicology of Shenzhen, Medical Key Laboratory of Health Toxicology, Laboratory of Modern Toxicology, Shenzhen Centre for Disease Control and Prevention, Shenzhen 518060, China; College of Food Science and Technology, Hunan Agricultural University, East Renmin Road, Changsha 410128, Hunan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xia
authors.affiliation: College of Horticulture and Gardening, Hunan Agricultural University, East Renmin Road, Changsha 410128, Hunan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Pang
authors.affiliation: Key Laboratory of Modern Toxicology of Shenzhen, Medical Key Laboratory of Health Toxicology, Laboratory of Modern Toxicology, Shenzhen Centre for Disease Control and Prevention, Shenzhen 518060, China. Electronic address: zxzhuang2007@sina.com.
authors.forename: Zhi-xiong
authors.initials: ZX
authors.lastname: Zhuang
authors.affiliation: Key Laboratory of Modern Toxicology of Shenzhen, Medical Key Laboratory of Health Toxicology, Laboratory of Modern Toxicology, Shenzhen Centre for Disease Control and Prevention, Shenzhen 518060, China. Electronic address: junii8@126.com.
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Liu
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D001710:Biotin / Q000494:pharmacology*; D063646:Carcinogenesis / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D019587:Dietary Supplements; D004785:Environmental Pollutants / Q000633:toxicity*; D004787:Environmental Pollution / Q000009:adverse effects; D044127:Epigenesis, Genetic / Q000187:drug effects*; D006801:Humans; D009747:Nutritional Physiological Phenomena; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D002273:Carcinogens; D004785:Environmental Pollutants; D014815:Vitamins; D001564:Benzo(a)pyrene; D001710:Biotin
keywords: Benzo[a]pyrene; Biotin; Carcinogenicity; Epigenetic modification