title: Prospects for the future of prostate cancer vaccines.
abstract: Cancer therapy is undergoing a revolution fueled by clinical data demonstrating that the immune system has significant anti-tumor capability. Although the main focus of this revolution currently rests upon immune checkpoint inhibitors in diseases such as melanoma, lung and bladder cancer, it was actually a therapeutic cancer vaccine in prostate cancer that provided the first data demonstrating that a modern immunotherapy, beyond cytokines, could enhance clinical outcomes. As immunotherapy is poised to take center stage among cancer therapies, the role of cancer vaccines remains somewhat undefined in prostate cancer, though emerging data suggest that vaccines could play a crucial therapeutic role.
authors.affiliation: a Genitourinary Malignancies Branch , National Cancer Institute , Bethesda , MD , USA.
authors.forename: Ravi A
authors.initials: RA
authors.lastname: Madan
authors.affiliation: a Genitourinary Malignancies Branch , National Cancer Institute , Bethesda , MD , USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Gulley
mesh_terms: D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000276:immunology / Q000302:isolation & purification*; D055808:Drug Discovery / Q000639:trends; D006801:Humans; D007167:Immunotherapy; D008297:Male; D011471:Prostatic Neoplasms / Q000628:therapy*
chemical_list: D019496:Cancer Vaccines
keywords: Vaccines; combination therapy; immune combinations; prostate cancer; therapeutic cancer vaccines