title: Optimizing the diagnosis and the treatment of iron overload diseases.
abstract: A number of human disorders are related to chronic iron overload, either of genetic or acquired origin. The multi-organ damage produced by iron excess leads, in adults and in children, to severe clinical consequences, affecting both quality of life and life expectancy. The diagnosis is increasingly based on a non-invasive strategy, resorting to clinical, biological and imaging data. The treatment rests on either venesection or chelation therapy, depending on the etiology. Major advances in the fields of molecular biology, pharmacology, and biotechnology pave the road for key improvements in the diagnostic and therapeutic management of the patients.
authors.affiliation: a Hepatology-Faculty of Medicine, Inserm-UMR 991, National Center of Reference for Rare Iron Overload Diseases , University Hospital Pontchaillou , Rennes , France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Brissot
mesh_terms: D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D020022:Genetic Predisposition to Disease; D006801:Humans; D007501:Iron / Q000097:blood; D007502:Iron Chelating Agents / Q000009:adverse effects / Q000627:therapeutic use*; D019190:Iron Overload / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D010641:Phenotype; D018962:Phlebotomy / Q000009:adverse effects; D011237:Predictive Value of Tests; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D007502:Iron Chelating Agents; D007501:Iron
keywords: Ferritin; Ferroportin; Hemochromatosis; Hemojuvelin; Hepcidin; Iron chelation; Iron overload; Non-transferrin bound iron; Transferrin saturation; Venesection