title: Attacking the Supply Lines: HIV-1 Restricts Alanine Uptake to Prevent T Cell Activation.
abstract: HIV commonly escapes host antiviral immunity by downregulating cell-surface immunoreceptors. In a recent issue of Cell Host & Microbe, Matheson et al. (2015) systematically examined how HIV-1 infection remodels the T cell surface and identified serine carriers SERINC3/5 and alanine transporter SNAT1 as targets of HIV-1 Nef and Vpu, respectively.
authors.affiliation: Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Montréal, QC H3T 1J4, Canada.
authors.forename: Scott
authors.initials: S
authors.lastname: Sugden
authors.affiliation: Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Montréal, QC H3T 1J4, Canada; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, QC H3T 1J4, Canada. Electronic address: eric.cohen@ircm.qc.ca.
authors.forename: Éric A
authors.initials: ÉA
authors.lastname: Cohen
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry*; D002462:Cell Membrane / Q000737:chemistry*; D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D054298:Human Immunodeficiency Virus Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000032:analysis*; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism*; D054311:nef Gene Products, Human Immunodeficiency Virus / Q000378:metabolism*
chemical_list: D054298:Human Immunodeficiency Virus Proteins; D008565:Membrane Proteins; D054334:Viral Regulatory and Accessory Proteins; D054311:nef Gene Products, Human Immunodeficiency Virus