title: Therapeutic Potential of Human Chorionic Gonadotropin Against Overactive Bladder.
abstract: Overactive bladder (OAB) is a common form of urinary incontinence, resulting from spontaneous and random contractions of the urinary bladder. The affected individuals have an uncontrollable urge to urinate and experience incontinence and nocturia, which can greatly reduce the quality of daily life. There are several drugs for the treatment, and all of them have serious side effects. The following findings suggested that human chorionic gonadotropin (hCG) has a therapeutic potential that is worth investigating for the treatment of OAB. The finding are (1) human detrusor muscle contains hCG receptors, (2) detrusor muscle becomes quiescent during pregnancy, (3) hCG can inhibit detrusor muscle contractions induced by cholinergic stimulation in rats, and (4) hCG can mimic the anticholinergic drug on detrusor muscle contractions.
authors.affiliation: Departments of Cellular Biology and Pharmacology, Molecular and Human Genetics, and Obstetrics and Gynecology, Reproduction and Development Program, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA crao@fiu.edu.
authors.forename: C V
authors.initials: CV
authors.lastname: Rao
mesh_terms: D000818:Animals; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000502:physiology; D008297:Male; D011974:Receptors, LH / Q000819:agonists / Q000502:physiology; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000503:physiopathology; D014549:Urinary Incontinence / Q000188:drug therapy
chemical_list: D018680:Cholinergic Antagonists; D006063:Chorionic Gonadotropin; D011974:Receptors, LH; D007986:Luteinizing Hormone
keywords: detrusor muscle; gonadotropins; hCG/LH receptors; overactive bladder; urinary bladder