title: Expression and Function of CD44 in Epithelial Ovarian Carcinoma.
abstract: CD44, a cell surface glycoprotein, has been increasingly implicated in the pathogenesis and progression of epithelial ovarian cancer, the deadliest gynecologic malignancy in women. Here, we review recent reports on the expression and function of CD44 in epithelial ovarian carcinoma. Further functional data for CD44 in peritoneal adhesion and metastatic progression and its association with stem cells is highlighted. Recent studies utilizing CD44 for therapeutic targeting are also discussed.
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, 335 College of Pharmacy Building, Chicago, IL 60612, USA. jsacks3@uic.edu.
authors.forename: Joelle D
authors.initials: JD
authors.lastname: Sacks
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, 335 College of Pharmacy Building, Chicago, IL 60612, USA. mvb@uic.edu.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Barbolina
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D011499:Protein Processing, Post-Translational
chemical_list: D018960:Hyaluronan Receptors
keywords: CD44; adhesion; cancer stem cells; epithelial ovarian carcinoma; hyaluronan; metastasis