title: The evolution of dual antiplatelet therapy in the setting of acute coronary syndrome: ticagrelor versus clopidogrel.
abstract: Review of: Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Eng J Med 2009; 361(11): 1045-1057. For acute coronary syndrome (ACS), a dual antiplatelet regimen comprised of treatment with aspirin and either P2Y12 adenosine diphosphate receptor antagonists, clopidogrel, prasugrel or ticagrelor is usually employed. This article compares clopidogrel with ticagrelor for the prevention of vascular events and death in broad population of ACS patients ranging from UA, NSTEMI to STEMI, utilizing planned strategies of medical or invasive treatment strategy.
authors.affiliation: a Department of Cardiology , Deborah Heart Lung and Center , Browns Mills , NJ , USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Amico
authors.affiliation: b Department of Pharmacy , St Johns University , Queens , NY , USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Amico
authors.affiliation: a Department of Cardiology , Deborah Heart Lung and Center , Browns Mills , NJ , USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Mazzoni
authors.affiliation: a Department of Cardiology , Deborah Heart Lung and Center , Browns Mills , NJ , USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Moshiyakhov
authors.affiliation: c Department of Internal Medicine , New York Hospital Queens , Flushing Queens , NY , USA.
authors.forename: William
authors.initials: W
authors.lastname: Tamparo
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D000241:Adenosine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D058919:Purinergic P2 Receptor Antagonists; D013988:Ticlopidine / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D058919:Purinergic P2 Receptor Antagonists; D000241:Adenosine; D013988:Ticlopidine
keywords: PLATO trial; STEMI; acute coronary syndrome; ticagrelor