title: Palladium-Catalyzed Phosphorylation of Aryl Mesylates and Tosylates.
abstract: The first general palladium catalyst for the phosphorylation of aryl mesylates and tosylates is reported. The newly developed system exhibits excellent functional group compatibility. For instance, free amino, keto, ester, and amido groups, as well as heterocycles, remain intact during the course of reaction. The mesylated derivatives of biologically active compounds such as 17β-estradiol and 6-hydroxyflavone are also shown to be applicable substrates. A one-pot phosphorylation-amination sequence is described for the facile synthesis of potential pharmacophores.
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University , Hung Hom, Kowloon, Hong Kong.
authors.forename: Wai Chung
authors.initials: WC
authors.lastname: Fu
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University , Hung Hom, Kowloon, Hong Kong.
authors.forename: Chau Ming
authors.initials: CM
authors.lastname: So
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University , Hung Hom, Kowloon, Hong Kong.
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
mesh_terms: D000586:Amination; D002384:Catalysis; D004958:Estradiol / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010766:Phosphorylation; D014105:Tosyl Compounds / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D008698:Mesylates; D014105:Tosyl Compounds; C529356:6-hydroxyflavone; D004958:Estradiol; D010165:Palladium