title: Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers.
abstract: Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.
authors.affiliation: Laborartoire de Biologie Cellulaire & Moléculaire, Université de Constantine 1, Constantine 25000, Alegria. hadjer25dz@hotmail.com.
authors.forename: Hadjer
authors.initials: H
authors.lastname: Daoudi
authors.affiliation: Physiologie de la Nutrition & Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup, Dijon 21000, France. plesnikjiri@gmail.com.|Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czech Republic. plesnikjiri@gmail.com.
authors.forename: Jiří
authors.initials: J
authors.lastname: Plesník
authors.affiliation: Laborartoire de Biologie Cellulaire & Moléculaire, Université de Constantine 1, Constantine 25000, Alegria. mirasayed0411@gmail.com.
authors.forename: Amira
authors.initials: A
authors.lastname: Sayed
authors.affiliation: Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 61137 Brno, Czech Republic. omarsery@sci.muni.cz.|Institute of Animal Physiology and Genetics, Academy of Science, Veveří 97, 60200 Brno, Czech Republic. omarsery@sci.muni.cz.
authors.forename: Omar
authors.initials: O
authors.lastname: Šerý
authors.affiliation: Laborartoire de Biologie Cellulaire & Moléculaire, Université de Constantine 1, Constantine 25000, Alegria. abdourouabah@hotmail.fr.
authors.forename: Abdelkader
authors.initials: A
authors.lastname: Rouabah
authors.affiliation: Laborartoire de Biologie Cellulaire & Moléculaire, Université de Constantine 1, Constantine 25000, Alegria. leilarouabah27@yahoo.fr.
authors.forename: Leila
authors.initials: L
authors.lastname: Rouabah
authors.affiliation: Physiologie de la Nutrition & Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup, Dijon 21000, France. Naim.Khan@u-bourgogne.fr.
authors.forename: Naim Akhtar
authors.initials: NA
authors.lastname: Khan
mesh_terms: D000293:Adolescent; D000462:Algeria; D000483:Alleles; D015992:Body Mass Index; D018955:CD36 Antigens / Q000235:genetics*; D004032:Diet; D004041:Dietary Fats; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D008297:Male; D009765:Obesity / Q000209:etiology / Q000235:genetics*; D019301:Oleic Acid; D020641:Polymorphism, Single Nucleotide; D013650:Taste Buds; D055697:Taste Perception; D013652:Taste Threshold; D013851:Thinness / Q000235:genetics*
chemical_list: D018955:CD36 Antigens; D004041:Dietary Fats; D006023:Glycoproteins; D019301:Oleic Acid
keywords: CD36; adolescents; obesity; oleic acid; taste