title: Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors.
abstract: Stem cells are characterized by the capacity for both self-renewal and generation of all other cell types (pluripotency) or differentiated cells within a particular lineage (multipotency). Stem cells are often localized to hypoxic niches within tissues and hypoxia inducible factors (HIFs) play key roles in the maintenance of pluripotent and multipotent stem cells, as well as cancer stem cells, which are also known as tumor-initiating cells. HIF inhibitors target cancer stem cells and improve the responses to angiogenesis inhibitors and cytotoxic chemotherapy in mouse models of breast cancer.
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine; Institute for Cell Engineering; and Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: gsemenza@jhmi.edu.
authors.forename: Gregg L
authors.initials: GL
authors.lastname: Semenza
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000166:cytology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D014411:Neoplastic Stem Cells / Q000166:cytology*
chemical_list: D051793:Hypoxia-Inducible Factor 1
keywords: Breast cancer stem cells; Embryonic stem cells; Glioma stem cells; Hematopoietic stem cells; Induced pluripotent stem cells; Leukemia stem cells