title: Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population.
abstract: Cardiovascular disease (CVD) is a major cause of mortality in type 1 diabetes mellitus (T1D). However, evidence of its risks and management is often extrapolated from studies in type 2 diabetic (T2D) patients or the general population. This approach is unsatisfactory given that the underlying pathology, demographics and natural history of the disease differ between T1D and T2D. Furthermore, with a rising life expectancy, a greater number of T1D patients are exposed to the cardiovascular (CV) risk factors associated with an ageing population. The aim of this review is to examine the existing literature around CVD in T1D. We pay particular attention to CVD prevalence, how well we manage risk, potential biomarkers, and whether the studies included the older aged patients (defined as aged over 65). We also discuss approaches to the management of CV risk in the older aged. The available data suggest a significant CVD burden in patients with T1D and poor management of CV risk factors. This is underpinned by a poor evidence base for therapeutic management of CV risk specifically for patients with T1D, and in the most relevant population - the older aged patients. We would suggest that important areas remain to be addressed, particularly exploring the risks and benefits of therapeutic approaches to CVD management in the older aged.
authors.affiliation: School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK.
authors.forename: Siang Ing
authors.initials: SI
authors.lastname: Lee
authors.affiliation: School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK.
authors.forename: Mitesh
authors.initials: M
authors.lastname: Patel
authors.affiliation: School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Jones
authors.affiliation: Institute of Biomedical Research, The Medical School, University of Birmingham, Edgbaston B15 2TT, UK.
authors.forename: Parth
authors.initials: P
authors.lastname: Narendran
keywords: Type 1 diabetes; ageing; cardiovascular disease; elderly; management; older adults; older aged; prevalence; risk factor; treatment