title: Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women' Lifestyle and Health Study.
abstract: BACKGROUND
  We aimed to estimate the effect of alcohol consumption on breast cancer risk and to test whether overweight and obesity modifies this association.
  
  
  METHODS
  We included in the analysis 45,233 women enrolled in the Swedish Women's Lifestyle and Health study between 1991 and 1992. Participants were followed for occurrence of breast cancer and death until December 2009. Poisson regression models were used, and analyses were done for overall breast cancer and for estrogen receptor positive or negative (ER+, ER-) and progesterone receptor positive and negative (PR+, PR-) tumors separately.
  
  
  RESULTS
  A total of 1,385 breast cancer cases were ascertained during the follow-up period. Overall, we found no statistically significant association between alcohol intake and breast cancer risk after adjustment for confounding, with an estimated relative risk (RR) of 1.01 (95 % CI: 0.98-1.04) for an increment in alcohol consumption of 5 g/day. A statistically significant elevated breast cancer risk associated with higher alcohol consumption was found only among women with BMI ≤25 (RR 1.03, 95 % CI 1.0-1.05 per 5 g/day increase).
  
  
  CONCLUSIONS
  An increase in breast cancer risk with higher alcohol consumption was found for breast cancers in women with a BMI ≤25 kg/m(2).
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea. shinaesun@snu.ac.kr.
authors.forename: Aesun
authors.initials: A
authors.lastname: Shin
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden. Sven.Sandin@ki.se.
authors.forename: Sven
authors.initials: S
authors.lastname: Sandin
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. Marie.Lof@ki.se.
authors.forename: Marie
authors.initials: M
authors.lastname: Lof
authors.affiliation: HealthPartners Institute for Education and Research, Minneapolis, USA. Karen.L.Margolis@HealthPartners.Com.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Margolis
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea. kyeezu@gmail.com.
authors.forename: Kyeezu
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden. Elisabeth.Couto@kunnskapssenteret.no.|Norwegian Knowledge Centre for the Health Services, Health Economic and Drug Unit, Oslo, Norway. Elisabeth.Couto@kunnskapssenteret.no.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Couto
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden. hadami@hsph.harvard.edu.|Department of Epidemiology, Harvard School of Public Health, Boston, USA. hadami@hsph.harvard.edu.
authors.forename: Hans Olov
authors.initials: HO
authors.lastname: Adami
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden. elisabete.weiderpass.vainio@ki.se.|Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway. elisabete.weiderpass.vainio@ki.se.|Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. elisabete.weiderpass.vainio@ki.se.|Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland. elisabete.weiderpass.vainio@ki.se.
authors.forename: Elisabete
authors.initials: E
authors.lastname: Weiderpass
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000473:pathology; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D017698:Postmenopause; D011960:Receptors, Estrogen / Q000097:blood / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics; D012307:Risk Factors; D013548:Sweden
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone