title: Diffusion-weighted magnetic resonance imaging in predicting the radiosensitivity of cervical cancer.
abstract: This study investigates the application value of diffusion-weighted magnetic resonance imaging in predicting cervical cancer radiosensitivity. Twenty-five patients who were newly diagnosed as cervical cancer and accepted simple radiotherapy were included in this study. Before external irradiation, 20 GY and at the end of irradiation, routine 1.5 T MRI and diffusion-weighted magnetic resonance imaging scanning were carried. Apparent diffusion coefficient (ADC) value of primary tumor was measured. Its correlation with tumor regression rate was analyzed. ADC values of before irradiation, 20 GY and at the end of irradiation was (0.93 ± 0.14) × 10(-3) mm(2)/s, (1.25 ± 0.17) × 10(-3) mm(2)/s and (1.55 ± 0.13) × 10(-3) mm(2)/s, respectively. There were statistical significant differences (P< 0.01). D-value of ADC values between before and 20 GY external irradiation was (0.33 ± 0.16) mm(2)/s. The tumor volume before and at the end of external irradiation were (37.48 ± 26.83) cm(3) and (4.41 ± 3.72) cm(3) respectively, with tumor regression rate of before and after external irradiation of (0.86 ± 0.11). ADC values of before irradiation, 20 GY and at the end of irradiation did not correlate with tumor regression rate. D-value of ADC values between before and 20 GY external irradiation positively correlated with tumor regression rate (r = 0.423, P = 0.035). ADC value of cervical cancer increased after radiotherapy and early changes of ADC value was positively correlated with tumor regression rate, thus, ADC value could be used as a potential prediction factor for cervical cancer radiosensitivity.
authors.affiliation: Department of Radiation Oncology, The First Hospital of Longyan Affiliated to Fujian Medical University Longyan 364000, P. R. China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Ni
authors.affiliation: Department of Radiation Oncology, The First Hospital of Longyan Affiliated to Fujian Medical University Longyan 364000, P. R. China.
authors.forename: Yuanhe
authors.initials: Y
authors.lastname: Tong
authors.affiliation: Department of Radiology, Fujian Cancer Hospital Fuzhou 350014, P. R. China.
authors.forename: Youping
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Radiology, Fujian Cancer Hospital Fuzhou 350014, P. R. China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Liao
authors.affiliation: Department of Radiology, Fujian Cancer Hospital Fuzhou 350014, P. R. China.
authors.forename: Yunbing
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Gynecological Oncology, Fujian Cancer Hospital Fuzhou 350014, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
keywords: Cervical cancer; apparent diffusion coefficient; diffusion-weighted magnetic resonance imaging; radiosensitivity