title: Pharmacogenomic agreement between two cancer cell line data sets.
abstract: Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two publicly available large-scale pharmacogenomics resources: The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer databases.
mesh_terms: D045744:Cell Line, Tumor / Q000187:drug effects*; D016208:Databases, Factual; D066264:Datasets as Topic; D006801:Humans; D020128:Inhibitory Concentration 50; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D010597:Pharmacogenetics; D015203:Reproducibility of Results