title: Role of the Red Ginseng in Defense against the Environmental Heat Stress in Sprague Dawley Rats.
abstract: Global temperature change causes heat stress related disorders in humans. A constituent of red ginseng has been known the beneficial effect on the resistance to many diseases. However, the mechanism of red ginseng (RG) against heat stress still remains unclear. To determine the effect of RG on heat stress, we examined the effect of the RG on the gene expression profiles in rats subjected to environmental heat stress. We evaluated the transcripts associated with hepatic lipid accumulation and oxidative stress in rats subjected to heat stress. We also analyzed the reactive oxygen species (ROS) contents. Our results suggested RG inhibited heat stress mediated altering mRNA expressions include HSPA1, DEAF1, HMGCR, and FMO1. We also determined RG attenuated fat accumulation in the liver by altering C/EBPβ expression. RG promoted to repress the heat stress mediated hepatic cell death by inhibiting of Bcl-2 expression in rats subjected to heat stress. Moreover, RG administered group during heat stress dramatically decreased the malondialdehyde (MDA) contents and ROS associated genes compared with the control group. Thus, we suggest that RG might influence inhibitory effect on environmental heat stress induced abnormal conditions in humans.
authors.affiliation: Department of Food Science and Biotechnology, College of Life Science, CHA University, Kyonggi 463-400, Korea. Kuijin.Kim@gmail.com.
authors.forename: Kui-Jin
authors.initials: KJ
authors.lastname: Kim
authors.affiliation: Department of Food Science and Biotechnology, College of Life Science, CHA University, Kyonggi 463-400, Korea. beautyygy@naver.com.
authors.forename: Kye-Yoon
authors.initials: KY
authors.lastname: Yoon
authors.affiliation: Korea Food Research Institute, Kyonggi, Seongnam 463-746, Korea. honghd@kfri.re.kr.
authors.forename: Hee-Do
authors.initials: HD
authors.lastname: Hong
authors.affiliation: Department of Food Science and Biotechnology, College of Life Science, CHA University, Kyonggi 463-400, Korea. bylee@cha.ac.kr.
authors.forename: Boo-Yong
authors.initials: BY
authors.lastname: Lee
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004777:Environment; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D018882:Heat Stress Disorders / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism*; D006358:Hot Temperature; D050356:Lipid Metabolism / Q000235:genetics; D015227:Lipid Peroxidation / Q000235:genetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D059467:Transcriptome
chemical_list: D010936:Plant Extracts
keywords: ginsenoside; heat environmental stress; herbal medicine; lipid accumulation; lipid peroxidation; red ginseng