title: [Localized Scleroderma of Lower Extremities:Clinical and Magnetic Resonance Imaging Features].
abstract: OBJECTIVE
  To evaluate the clinical and musculoskeletal characteristics of localized scleroderma with lower extremities affected.
  
  
  METHODS
  All the localized scleroderma patients,who received magnetic resonance (MR ) examinations of affected lower extremities at Peking Union Medical College Hospital from April 2013 to June 2014,were retrospectively reviewed. Their clinical data and laboratory results of antinuclear antibody,anti-double stranded-DNA antibody, and anti-extractable nuclear antigen antibody were collected and analyzed. All the MR examinations were non-contrast imaging using Siemens Skyra 3.0T MR scanner.
  
  
  RESULTS
  There were 16 localized scleroderma patients with lower extremities affected, 11 of whom were linear scleroderma, 4 generalized morphea, and 1 deep morphea. Female to male ratio was 1:2.2. The mean age was 22.5 years. The mean time span was 7.4 years. Four of the 14 patients (28.6%) who received antinuclear antibody test were positive. All the 10 patients who received anti-double stranded-DNA antibody test and the 7 patients who received anti-extractable nuclear antigen antibody test were negative. The most common musculoskeletal MR features were subcutaneous septal thickening (16/16) and fascial thickening (11/16). The thickened speta and fascia could either be hypointenstiy or hyperintensity on turbo inversion recovery magnitude/proton density weighted imaging. Other MR manifestations were intramuscular speta thickening (3/16), muscular abnormal signals (1/16), and bone marrow abnormal signals (2/16).
  
  
  CONCLUSIONS
  Musculoskeletal manifestations of the lower extremities with localized scleroderma can be well revealed using MR imaging.
authors.affiliation: Department of Radiology,2Department of Dermatology,3Department of Orthopedics,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Feng-dan
authors.initials: FD
authors.lastname: Wang
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Wang
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Wu
authors.affiliation: Department of Radiology,2Department of Dermatology,3Department of Orthopedics,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hou
authors.affiliation: Department of Radiology,2Department of Dermatology,3Department of Orthopedics,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Radiology,2Department of Dermatology,3Department of Orthopedics,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Radiology,2Department of Dermatology,3Department of Orthopedics,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Feng
authors.initials: F
authors.lastname: Feng
authors.affiliation: Department of Radiology,2Department of Dermatology,3Department of Orthopedics,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Zheng-yu
authors.initials: ZY
authors.lastname: Jin
authors.forename: Xie
authors.initials: X
authors.lastname: Yuan
mesh_terms: D000974:Antibodies, Antinuclear; D005260:Female; D006801:Humans; D035002:Lower Extremity; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D012594:Scleroderma, Localized
chemical_list: D000974:Antibodies, Antinuclear