title: Magnetically targeted delivery of DOX loaded Cu9S5@mSiO2@Fe3O4-PEG nanocomposites for combined MR imaging and chemo/photothermal synergistic therapy.
abstract: The combination of multi-theranostic modes in a controlled fashion has received tremendous attention for the construction of cooperative therapeutic systems in nanomedicine. Herein, we have synthesized a smart magnetically targeted nanocarrier system, Cu9S5@mSiO2@Fe3O4-PEG (labelled as CMF), which integrates NIR triggered photothermal therapy, pH/NIR-responsive chemotherapy and MR imaging into one nanoplatform to enhance the therapeutic efficacy. This new multifunctional paradigm has a uniform and monodisperse sesame ball-like structure by decorating tiny Fe3O4 nanoparticles on the surface of Cu9S5@mSiO2 before a further PEG modification to improve its hydrophilicity and biocompatibility. With doxorubicin (DOX) payload, the as-obtained CMF-DOX composites can simultaneously provide an intense heating effect and enhanced DOX release upon 980 nm NIR light exposure, achieving a combined chemo/photothermal therapy. Under the influence of an external magnetic field, the magnetically targeted synergistic therapeutic effect of CMF-DOX can lead to highly superior inhibition of animal H22 tumor in vivo when compared to any of the single approaches alone. The results revealed that this Cu9S5 based magnetically targeted chemo/photothermal synergistic nanocarrier system has great promise in future MR imaging assisted tumor targeted therapy of cancer.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jlin@ciac.ac.cn cxli@ciac.ac.cn.
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.forename: Xinyang
authors.initials: X
authors.lastname: Zhang
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Yinyin
authors.initials: Y
authors.lastname: Chen
authors.forename: Shanshan
authors.initials: S
authors.lastname: Huang
authors.forename: Dayong
authors.initials: D
authors.lastname: Jin
authors.forename: Piaoping
authors.initials: P
authors.lastname: Yang
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008279:Magnetic Resonance Imaging; D051379:Mice; D053761:Nanocomposites; D053758:Nanoparticles; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010778:Photochemotherapy
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin