title: Association study of apolipoprotein E promoter polymorphism (-427 T/C) and Alzheimer's disease in a Tunisian population.
abstract: BACKGROUND
  Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an as yet poorly understood etiology. Both environmental and genetic factors have been implicated as predisposing factors. The apolipoprotein E (APOE) ɛ4 allele is an established genetic susceptibility factor for AD for several populations including the Tunisian population. Polymorphism rs769446 (-427 T/C) at the promoter region of the APOE gene is postulated to affect the expression of the gene through differential binding of transcription factors.
  
  
  OBJECTIVE
  This study aims at examining the APOE promoter polymorphism rs769446 for possible association with AD in a Tunisian population.
  
  
  METHODS
  Using a case-control study design, a sample of 85 patients and 90 controls were investigated for association with the rs769446 polymorphism.
  
  
  RESULTS
  No evidence of association was found in this population upon comparison between patients and healthy controls or upon stratification by APOE ɛ4.
  
  
  CONCLUSIONS
  Investigations of potential gene-gene and gene-environmental interactions for this polymorphism need to be further conducted.
authors.affiliation: Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia; Biochemistry and molecular biology laboratory, Children's hospital, Bab Saadoun, 1029 Tunis, Tunisia. Electronic address: achouriafef@yahoo.fr.
authors.forename: A
authors.initials: A
authors.lastname: Achouri-Rassas
authors.affiliation: Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Ben Ali
authors.affiliation: Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Fray
authors.affiliation: Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Kechaou
authors.affiliation: Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Oudiaa Zakraoui
authors.affiliation: Biochemistry and molecular biology laboratory, Children's hospital, Bab Saadoun, 1029 Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Hadj-Fredj
authors.affiliation: Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Cherif
authors.affiliation: Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Anane
authors.affiliation: Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Echebi
authors.affiliation: Biochemistry and molecular biology laboratory, Children's hospital, Bab Saadoun, 1029 Tunis, Tunisia.
authors.forename: T
authors.initials: T
authors.lastname: Messaoud
authors.affiliation: Neurological department, Charles Nicolle hospital, boulevard du 9 Avril, 1006 Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Belal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014416:Tunisia
chemical_list: D053327:Apolipoprotein E4
keywords: Alzheimer's disease; Apolipoprotein E; Facteur de risque; L’apolipoprotéine E; Maladie d’Alzheimer; Polymorphisme du promoteur; Promoter polymorphism; Risk factor