title: [Distribution of HCV genotypes in Chinese Han population with chronic hepatitis C].
abstract: To investigate the distribution of HCV genotypes in Chinese Han population with chronic hepatitis C (CHC).
  
  
  
  This randomized multicenter study included 1 014 CHC patients from 28 hospitals in different regions of China. SPSS 20.0 was applied to analyze the relationship among region, HCV genotype, gender and the replication level of HCV-RNA.
  
  
  
  HCV 1 genotype (56.80%) was the most common genotype. The majority of CHC patients were of genotype 1, 2, 3, 6 in the order of frequency, except those in southwestern, southern and central China. HCV 1, 2, 3, 6 genotypes were most common among male patients in southern China; among female patients in northern China; among male patients in northern and northwestern China and among male patients in northwestern China, respectively (all P <0.05). There was no statistical significance between different genders in other regions. The high viral load was more common than the low viral load among HCV 1, 2, 3, 6 genotype-infected patients.
  
  
  
  There are different distributions of HCV genotypes among the different regions. In addition, HCV genotypes are correlated with gender and HCV-RNA load.
authors.affiliation: Department of Infectious Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Mao
authors.affiliation: Department of Infectious Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Li-ting
authors.initials: LT
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Department of Infectious Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xiao
authors.affiliation: Department of Infectious Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: Xue-bin
authors.initials: XB
authors.lastname: Peng
authors.affiliation: Department of General Surgery, the Second Hospital of Lanzhou University, Lanzhou 730000, China.
authors.forename: You-cheng
authors.initials: YC
authors.lastname: Zhang
mesh_terms: D044466:Asian People; D002681:China; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000821:virology*; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic; D019562:Viral Load