title: A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma.
abstract: Temporal bone squamous cell carcinoma (TBSCC) is an uncommon malignancy with a distinctly poor prognosis in advanced cases. There is still much controversy surrounding the rational diagnostic/therapeutic approach to TBSCC. Diagnostic differences are due mainly to: the small number of cases reported (even in the largest available series); the inappropriate histological heterogeneity of several case series; the lack of an internationally-accepted staging system for TBSCC; the frequent absence of adequate radiological imaging to enable a malignancy's local, regional and distant extension to be studied in detail; and a non-standardized approach to final histological assessment of the surgical margins. As for the therapeutic approaches, several issues are still debated, including the choice between en bloc and piecemeal primary surgery for the tumor's removal, and the role of elective neck dissection. Although radiotherapy seems to be an effective adjuvant therapy in advanced cases, its role in low-stage tumors or as a primary treatment has yet to be established. The value of chemotherapy is also still unclear. The treatment strategy for TBSCC is often based on the combined experience of a given surgeon and institution, bearing the results reportedly achieved by other oncology centers in mind. To date, the optimal management of TBSCC is still elusive. We aimed to critically review the ongoing crucial issues concerning the management of TBSCC, analyzing how it is diagnosed, staged and treated, the management of recurrences, rational follow-up schedules, and prognostic factors for this disease.
authors.affiliation: Department of Neurosciences DNS, Otolaryngology Section, University of Padova, Padova, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Zanoletti
authors.affiliation: Department of Neurosciences DNS, Otolaryngology Section, University of Padova, Padova, Italy; Department of Otolaryngology - Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lovato
authors.affiliation: Department of Neurosciences DNS, Otolaryngology Section, University of Padova, Padova, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Stritoni
authors.affiliation: Department of Neurosciences DNS, Otolaryngology Section, University of Padova, Padova, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martini
authors.affiliation: Department of Neurosciences DNS, Otolaryngology Section, University of Padova, Padova, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Mazzoni
authors.affiliation: Department of Neurosciences DNS, Otolaryngology Section, University of Padova, Padova, Italy. Electronic address: gino.marioni@unipd.it.
authors.forename: Gino
authors.initials: G
authors.lastname: Marioni
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012888:Skull Neoplasms / Q000175:diagnosis / Q000628:therapy*; D000077195:Squamous Cell Carcinoma of Head and Neck; D013701:Temporal Bone / Q000473:pathology / Q000601:surgery*
keywords: Diagnosis; Pitfalls; Prognosis; Temporal bone carcinoma; Treatment