title: Diversity of CRISPR-Cas immune systems and molecular machines.
abstract: Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.
authors.affiliation: Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC, 27695, USA. rbarran@ncsu.edu.
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Barrangou
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics*; D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000276:immunology; D064113:CRISPR-Cas Systems / Q000235:genetics* / Q000276:immunology; D004247:DNA / Q000235:genetics; D005818:Genetic Engineering / Q000379:methods; D014644:Genetic Variation / Q000235:genetics* / Q000276:immunology; D006801:Humans; D017393:RNA Editing / Q000235:genetics
chemical_list: D004247:DNA