title: [Infection status of enterovirus 71 and coxsackievirus A16 among children receiving health examination for child care setting entrance in Beijing and their related medical care seeking practice].
abstract: OBJECTIVE
  To understand the infection status of enterovirus 71 (EV71) and coxsackievirus A16 (Cox A16) among children receiving health examination for child care setting entrance in Beijing and their related medical care seeking practice and provide evidence for the estimation of disease burden caused by hand foot and mouth disease (HFMD).
  
  
  METHODS
  Serological survey was conducted in the local children receiving health examination for child care setting entrance. Enzyme-linked immunosorbent assay (ELISA) was conducted to detect anti-EV71 and anti-Cox A16 IgG and IgM.
  
  
  RESULTS
  A total of 813 children were surveyed (mean age: 3.5 ± 1.0 year old). The seropositive rate was 61.9% and 4.4% for anti-Cox A16 IgG and IgM. The seropositive rate was 9.3% and 1.1% for anti-EV71 IgG and IgM. No significant difference was observed in sex specific seropositive rate (P > 0.05). However, significant differences were found in seropositive rate among different age groups (P < 0.05). Among the children who were anti-Cox A16 positive, 7.8% had ever had rashes on their hands and feet, mouth or buttocks (HFMD-like rashes). Among the children who were anti-EV71 positive, 10.7% had ever had HFMD-like rashes. For the children who were anti-Cox A16 or anti-EV71 positive, only 7.1% were brought to see doctors by their parents. However, among the seropositive children with rashes, 80.5% were brought to see doctors.
  
  
  CONCLUSIONS
  In the healthy children at the age to go to child care setting in Beijing, most had ever infected with Cox A16. The anti-EV71 positive rate was much lower than the anti-Cox A16 positive rate. It was necessary to strengthen the prevention and control of EV71 infection in child cares settings.
authors.affiliation: Beijing Municipal Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Beijing Municipal Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Changying
authors.initials: C
authors.lastname: Lin
authors.affiliation: Dongcheng District Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Chaoyang District Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Ma
authors.affiliation: Huairou District Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Beijing Municipal Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Beijing Municipal Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jia
authors.affiliation: Beijing Municipal Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Beijing Municipal Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Du
authors.affiliation: Beijing Municipal Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Beijing Municipal Center for Disease Control and Prevention, Beijing 100013, China.
authors.forename: Quanyi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Beijing Municipal Center for Disease Control and Prevention, Beijing 100013, China; Email: hexiong@vip.163.com.
authors.forename: Xiong
authors.initials: X
authors.lastname: He
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D000068476:Beijing / Q000453:epidemiology; D002662:Child Health Services / Q000706:statistics & numerical data*; D002675:Child, Preschool; D017281:Cost of Illness; D029821:Enterovirus A, Human / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D010290:Parents / Q000523:psychology; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data*
chemical_list: D000888:Antibodies, Anti-Idiotypic; C048844:anti-IgG; C044203:anti-IgM