title: The serum levels of MMP-9, MMP-2 and vWF in patients with low doses of urokinase peritoneal dialysis decreased uremia complicated with cerebral infarction.
abstract: To investigate the effect of MMP-9, MMP-2 and vWF in patients with low doses of urokinase peritoneal dialysis decreased uremia complicated with cerebral infarction. 112 cases of uremia complicated with cerebral infarction were randomly divided into the peritoneal dialysate with urokinase treatment group (66 cases) and the conventional treatment group (46 cases). At the same time, 50 cases of healthy people who were more than 45 years old were enrolled in the control group. The basic treatment in both treatment groups was the same. In urokinase therapy group based on the conventional treatment, urokinase was added into peritoneal dialysis fluid, and changes of serum MMP-9, MMP-2 and vWF were observed by drawing blood at different time points within 8 weeks. The changes of serum MMP-2, MMP-9 and vWF were detected by enzyme-linked immunosorbent assay. At the time of the onset of uremia complicated with cerebral infarction patients the serum MMP-9, MMP-2, vWF were significantly higher (P<0.05, P<0.05, P<0.01). Conventional antiplatelet therapy in brain protection only reduce MMP-9 to the normal range (P>0.05) within 8 weeks. But the MMP-2 and vWF cannot be reduced to the normal range (P<0.01, P<0.01). Low doses of urokinase can reduce MMP-9 (7 d) and MMP-2 (14 d) to the normal range (P>0.05, P>0.05) at the early stage and decrease the vWF to a normal range within 8 weeks (P>0.05). At the time of the onset of uremia complicated with cerebral infarction patients the serum MMP-9, MMP-2 and vWF increased significantly. Low doses of urokinase dialysis can reduce serum MMP-9, MMP-2, and vWF in acute uremia complicated with cerebral infarction without recurrence of cerebral infarction and cerebral hemorrhagic transformation, indicating that low dose of urokinase peritoneal dialysis may have a certain effect on the early treatment of this disease.
authors.affiliation: Department of Neurology, The First Hospital of Zibo Affiliated Weifang Medical University Zibo 25520, China.
authors.forename: Shu-Jin
authors.initials: SJ
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shanghai Jiao Tong University Affiliated The Sixth People's Hospital Yi Shan Road 600, Shanghai 200233, China.
authors.forename: Zhong-Sen
authors.initials: ZS
authors.lastname: Qu
authors.affiliation: Department of Internal Medicine, Heze High Medical School Heze 274030, China.
authors.forename: Qing-De
authors.initials: QD
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Qingdao University Affiliated The Central Hospital Qingdao 266042, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Neurology, Shanghai Jiao Tong University Affiliated The Sixth People's Hospital Yi Shan Road 600, Shanghai 200233, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shanghai Jiao Tong University Affiliated The Sixth People's Hospital Yi Shan Road 600, Shanghai 200233, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Hospital of Zibo Affiliated Weifang Medical University Zibo 25520, China.
authors.forename: Bang-Li
authors.initials: BL
authors.lastname: Wu
authors.affiliation: Department of Neurology, Shanghai Jiao Tong University Affiliated The Sixth People's Hospital Yi Shan Road 600, Shanghai 200233, China.
authors.forename: Yu-Wu
authors.initials: YW
authors.lastname: Zhao
keywords: Uremia; infarction; matrix metalloproteinases; urokinase; von Willebrand factor