title: Roles of antibody against oxygenized low density lipoprotein in atherosclerosis: recent advances.
abstract: Atherosclerosis is a chronic immune inflammatory disease. Atherosclerosis and relevant disease are threatening human life and health. Oxygenized low density lipoprotein (oxLDL) is a molecular basis in the pathogenesis of atherosclerosis and able to induce inflammation, stimulate immune system and interfere with lipid metabolism in the occurrence and development of atherosclerosis. Antibody against oxLDL has been an important molecule in the immune related pathogenesis of atherosclerosis. In available studies on atherosclerosis, antibody against oxLDL has been a focus, but how oxLDL acts to affect the atherosclerosis and relevant diseases, whether oxLDL is protective or detrimental, and whether oxLDL acts in different ways at different stages of atherosclerosis are still unclear. This paper focuses on the role of antibody against oxLDL in the atherosclerosis and relevant diseases, and summarizes the advances in this field, aiming to provide new clue and new methods for the therapy of atherosclerosis.
authors.affiliation: Second Xiangya Hospital, Central South University Changsha 410011, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Second Xiangya Hospital, Central South University Changsha 410011, China ; Department of Cardiology, Northern Jiangsu People's Hospital, Medical College of Yangzhou University Yangzhou 225001, China.
authors.forename: Daxin
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Northern Jiangsu People's Hospital, Medical College of Yangzhou University Yangzhou 225001, China.
authors.forename: Shenghu
authors.initials: S
authors.lastname: He
keywords: Oxygenized low density lipoprotein; antibody against oxygenized low density lipoprotein; atherosclerosis; new detection method