title: Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor.
abstract: BACKGROUND
  Upregulation of heparanase has been reported in an increasing number of human cancer tissues. However, the level of salivary heparanase and its clinical significance in patients with salivary gland tumors remain unclear.
  
  
  METHODS
  Salivary heparanase levels in patients with salivary gland tumors were detected using enzyme-linked immunosorbent assays (ELISAs) and the clinical significance was evaluated by analyzing the correlations among salivary heparanase levels, clinicopathological parameters, and clinical outcomes.
  
  
  RESULTS
  The levels of salivary heparanase were significantly higher in patients with malignant salivary gland tumors than in benign tumors and normal controls (P<0.0001). High salivary heparanase levels were positively correlated with increased lymph node metastasis (P = 0.0235) and poorer tumor node metastasis stage (TNM) (P = 0.0183). Survival analyses revealed that high salivary heparanase levels were associated with worse overall survival (P = 0.0023) and disease-free survival (DFS) (P = 0.0025).
  
  
  CONCLUSIONS
  The study shows that salivary heparanase levels, as detected by the ELISAs, can be used to diagnose and provide an accurate prognosis for malignant salivary gland tumors. Salivary heparanase level was an independent predictor in patients with malignant salivary gland tumors.
authors.affiliation: Department of Stomatology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
authors.forename: Xiangbing
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Stomatology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.affiliation: Center of Stomatology, Central Hospital of Enshi Autonomous Prefecture, Enshi, China.
authors.forename: Guilin
authors.initials: G
authors.lastname: Gao
authors.affiliation: Department of Stomatology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Stomatology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Shengrong
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Stomatology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
authors.forename: Zhongjian
authors.initials: Z
authors.lastname: Gong
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005966:Glucuronidase / Q000032:analysis*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D012469:Salivary Glands / Q000201:enzymology* / Q000473:pathology; D015854:Up-Regulation; D000099175:Heparanase
chemical_list: D014408:Biomarkers, Tumor; D005966:Glucuronidase; D000099175:Heparanase