title: CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype.
abstract: Databases pertaining to various diseases provide valuable resources on particular genes of interest but lack the molecular subtype and epithelial-mesenchymal transition status. CSIOVDB is a transcriptomic microarray database of 3,431 human ovarian cancers, including carcinoma of the ovary, fallopian tube, and peritoneum, and metastasis to the ovary. The database also comprises stroma and ovarian surface epithelium from normal ovary tissue, as well as over 400 early-stage ovarian cancers. This unique database presents the molecular subtype and epithelial-mesenchymal transition status for each ovarian cancer sample, with major ovarian cancer histologies (clear cell, endometrioid, mucinous, low-grade serous, serous) represented. Clinico-pathological parameters available include tumor grade, surgical debulking status, clinical response and age. The database has 1,868 and 1,516 samples with information pertaining to overall and disease-free survival rates, respectively. The database also provides integration with the copy number, DNA methylation and mutation data from TCGA. CSIOVDB seeks to provide a resource for biomarker and therapeutic target exploration for ovarian cancer research.
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore 117599.
authors.forename: Tuan Zea
authors.initials: TZ
authors.lastname: Tan
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore 117599.
authors.forename: He
authors.initials: H
authors.lastname: Yang
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore 117599.
authors.forename: Jieru
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department of Obstetrics and Gynecology, National University Health System, Singapore 119228.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Low
authors.affiliation: Department of Obstetrics and Gynecology, National University Health System, Singapore 119228.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Choolani
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore 117599.|Department of Obstetrics and Gynecology, National University Health System, Singapore 119228.|Department of Haematology-Oncology, National University Hospital, Singapore 119074.
authors.forename: David Shao Peng
authors.initials: DS
authors.lastname: Tan
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore 117599.|Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore 138673.|Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Thiery
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore 117599.|Department of Obstetrics and Gynecology, National University Health System, Singapore 119228.|Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596.|Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596.
authors.forename: Ruby Yun-Ju
authors.initials: RY
authors.lastname: Huang
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D030541:Databases, Genetic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D010051:Ovarian Neoplasms / Q000235:genetics*
keywords: database; microarray gene expression; molecular subtype; ovarian cancer