title: PEG-Biscyanoacrylate Crosslinker for Octyl Cyanoacrylate Bioadhesive.
abstract: PEG400 (polyethylene glycol, MW 400) biscyanoacrylate is synthesized and copolymerized with 2-octyl cyanoacrylate for potential use as bioadhesive. PEG400 biscyanoacrylate is synthesized from the esterification of anthracenyl cyanoacrylic acid where the anthracene unit serves as vinyl-protecting group. Copolymerization increases the plasticity, mechanical strength, and resilience of the resulted polymer as determined by dynamic mechanical analysis. Peeling test confirms its superior bioadhesive properties. Surface morphology is characterized by SEM imaging. The formulations are cytocompatible and safe. This cyanoacrylate composition may provide improved bioadhesive cyanoacrylates.
authors.affiliation: Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
authors.forename: Arijit
authors.initials: A
authors.lastname: Basu
authors.affiliation: Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
authors.forename: Ilana
authors.initials: I
authors.lastname: Veprinsky-Zuzulia
authors.affiliation: Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
authors.forename: Mira
authors.initials: M
authors.lastname: Levinman
authors.affiliation: Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Barkan
authors.affiliation: Department of Microbiology and Molecular Genetics, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
authors.forename: Jacob
authors.initials: J
authors.lastname: Golenser
authors.affiliation: Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Domb
mesh_terms: D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003487:Cyanoacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D004548:Elasticity; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D012212:Rheology; D014014:Tissue Adhesives / Q000494:pharmacology*; D014783:Viscosity
chemical_list: D003432:Cross-Linking Reagents; D003487:Cyanoacrylates; D014014:Tissue Adhesives; D011092:Polyethylene Glycols; C100832:octyl 2-cyanoacrylate
keywords: 2-octyl cyanoacrylate; PEG biscyanoacrylate; bioadhesives; plasticity; viscoelasticity