title: Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation.
abstract: Aggregation at the neuronal cell membrane's lipid bilayer surface is implicated in amyloid-β (Aβ) toxicity associated with Alzheimer's disease; however, structural and mechanistic insights into the process remain scarce. We have identified a conserved binding mode of Aβ40 on lipid bilayer surfaces with a conserved helix containing the self-recognition site (K16-E22).
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu.
authors.forename: Kyle J
authors.initials: KJ
authors.lastname: Korshavn
authors.affiliation: Biophysics Program, University of Michigan, Ann Arbor, MI 48109, USA and Department of Biophysics, Bose Institute, Kolkata 700 054, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Bhunia
authors.affiliation: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Lim
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu and Biophysics Program, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Ayyalusamy
authors.initials: A
authors.lastname: Ramamoorthy
mesh_terms: D000682:Amyloid / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism*; D001665:Binding Sites; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D013499:Surface Properties
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D008051:Lipid Bilayers