title: Optimal detection of infratentorial lesions with a combined dual-echo MRI sequence: "PT2".
abstract: The infratentorial compartment is cardinal for multiple sclerosis (MS) diagnosis. T2-weighted (T2) and proton density-weighted (PD) magnetic resonance imaging (MRI) can visualize infratentorial lesions, but only suboptimally.
  
  
  
  To combine PD and T2 for better lesion assessment.
  
  
  
  T2 and PD from 35 cases were averaged to form "PT2" images. Two raters counted infratentorial lesions and qualitatively assessed their conspicuity.
  
  
  
  PT2 showed 244 infratentorial lesions, of which 94% and 74% were seen in PD and T2. PT2 received higher grades for image quality and lesion conspicuity (p < 0.001 for all comparisons).
  
  
  
  PT2 could improve our ability to diagnose and monitor MS.
authors.affiliation: Department of Neurology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina migaitan@fleni.org.ar.
authors.forename: María I
authors.initials: MI
authors.lastname: Gaitán
authors.affiliation: Department of Radiology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.
authors.forename: Paulina
authors.initials: P
authors.lastname: Yañes
authors.affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Pascal
authors.initials: P
authors.lastname: Sati
authors.affiliation: Department of Radiology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.
authors.forename: Carlos
authors.initials: C
authors.lastname: Romero
authors.affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Reich
authors.affiliation: Department of Neurology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.
authors.forename: Jorge
authors.initials: J
authors.lastname: Correale
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging*
keywords: MRI; Multiple sclerosis; T2 lesions; infratentorial brain