title: A dynamic model for the outbreaks of hand, foot, and mouth disease in Taiwan.
abstract: The first large outbreak of hand, foot, and mouth disease (HFMD) with severe complications primarily caused by enterovirus 71 was reported in Taiwan in 1998. Surveillance of HFMD to evaluate the spread of HFMD with and without infection control policy is needed. We developed a new dynamic epidemic Susceptible-Infected-Recovered (SIR) model to fit the surveillance data on containing valuable information on the severity of HFMD in order to accurately estimate the basic reproductive number (R 0) of HFMD. After fitting the empirical data, in conjunction with other relevant parameters extracted from the literature, the estimated transmission coefficients were close to 5 × 10-7 (per day) and the proportion of severe HFMD cases ranged between 0 and 0·0036 (per day). Taking into account the distribution of all parameters considered in our dynamic epidemic model, the R 0 computed was 1·37 (95% confidence interval 0·24-5·84), suggesting a higher likelihood of the spread of HFMD if no infection control policy is provided. The isolation strategy against the spread of HFMD not only delayed the epidemic peak with the delayed time ranging from 4 weeks for only 20% isolation to 47 weeks for 100% isolation but also reduced total number of HFMD cases with the percentage of reduction ranging from 1·3% for only 20% isolation to 13·3% for 100% isolation. The proposed model can also be flexible for evaluating the effectiveness of two other possible policies for containing HFMD, quarantine and vaccination (if the vaccine can be developed).
authors.affiliation: Emergency Department,Taipei City Hospital,Ren-Ai Branch,Taiwan.
authors.forename: C-C
authors.initials: CC
authors.lastname: Lai
authors.affiliation: Field Epidemiology Training Program,Centres for Disease Control,Taiwan.
authors.forename: D-S
authors.initials: DS
authors.lastname: Jiang
authors.affiliation: Graduate Institute of Epidemiology and Preventive Medicine,College of Public Health,National Taiwan University,Division Biostatistics,TaipeiTaiwan.
authors.forename: H-M
authors.initials: HM
authors.lastname: Wu
authors.affiliation: Graduate Institute of Epidemiology and Preventive Medicine,College of Public Health,National Taiwan University,Division Biostatistics,TaipeiTaiwan.
authors.forename: H-H
authors.initials: HH
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D029821:Enterovirus A, Human / Q000502:physiology*; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D008962:Models, Theoretical; D011159:Population Surveillance / Q000379:methods*; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
keywords: Compartmental model; SIR model; and mouth disease (HFMD); enterovirus 71; foot; hand; reproductive number