title: Development of New Strategies for Echinocandins: Progress in Translational Research.
abstract: Echinocandins are N-acyl-substituted cyclic hexapeptides with potent in vitro and in vivo activity against Candida species that are used for primary treatment and prevention of candidemia and invasive candidiasis. Recent progress in the translational research of echinocandins has led to new approaches for treatment of central venous catheter Candida biofilms. Other studies have laid the experimental and clinical foundation for use of extended dosing intervals for administration of echinocandins in treatment and prevention of candidemia and invasive candidiasis.
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine Department of Pediatrics Department of Microbiology and Immunology, Weill Cornell Medical Center of Cornell University, New York, New York.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
authors.affiliation: Astellas Pharma Global Development, Northbrook, Illinois.
authors.forename: Nkechi
authors.initials: N
authors.lastname: Azie
authors.affiliation: University of Wisconsin School of Medicine and Public Health, Madison.
authors.forename: David R
authors.initials: DR
authors.lastname: Andes
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects; D002175:Candida / Q000187:drug effects* / Q000502:physiology; D058387:Candidemia / Q000188:drug therapy / Q000517:prevention & control; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D058365:Candidiasis, Invasive / Q000188:drug therapy / Q000517:prevention & control; D000077336:Caspofungin; D055499:Catheter-Related Infections / Q000188:drug therapy; D054714:Echinocandins / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D055666:Lipopeptides / Q000627:therapeutic use; D000077551:Micafungin; D057170:Translational Research, Biomedical
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin; D000077551:Micafungin
keywords: anidulafungin; caspofungin; echinocandins; micafungin