title: More than just trash bins? Potential roles for extracellular vesicles in the vertical and horizontal transmission of yeast prions.
abstract: In the yeast Saccharomyces cerevisiae, an ensemble of structurally and functionally diverse cytoplasmic proteins has the ability to form self-perpetuating protein aggregates (e.g. prions) which are the vectors of heritable non-Mendelian phenotypic traits. Whether harboring these prions is deleterious-akin to mammalian degenerative disorders-or beneficial-as epigenetic modifiers of gene expression-for yeasts has been intensely debated and strong arguments were made in support of both views. We recently reported that the yeast prion protein Sup35p is exported via extracellular vesicles (EV), both in its soluble and aggregated infectious states. Herein, we discuss the possible implications of this observation and propose several hypotheses regarding the roles of EV in both vertical and horizontal propagation of 'good' and 'bad' yeast prions.
authors.affiliation: Centre National de la Recherche Scientifique (CNRS), Paris-Saclay Institute of Neuroscience, Université Paris-Saclay, Bât. 32-33, Avenue de la Terrasse, 91190, Gif-sur-Yvette, France. Mehdi.Kabani@lebs.cnrs-gif.fr.
authors.forename: Mehdi
authors.identifier: http://orcid.org/0000-0001-7440-6394
authors.initials: M
authors.lastname: Kabani
authors.affiliation: Centre National de la Recherche Scientifique (CNRS), Paris-Saclay Institute of Neuroscience, Université Paris-Saclay, Bât. 32-33, Avenue de la Terrasse, 91190, Gif-sur-Yvette, France. Ronald.Melki@lebs.cnrs-gif.fr.
authors.forename: Ronald
authors.initials: R
authors.lastname: Melki
mesh_terms: D000818:Animals; D000067128:Extracellular Vesicles / Q000235:genetics / Q000378:metabolism*; D000072002:Prion Proteins / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000072002:Prion Proteins; D029701:Saccharomyces cerevisiae Proteins
keywords: Exosome; Extracellular vesicle; Prion; SUP35; Yeast; [PSI +]