title: Enhanced Bioavailability and Anticancer Effect of Curcumin-Loaded Electrospun Nanofiber: In Vitro and In Vivo Study.
abstract: Nanofibers have attracted increasing attention in drug delivery and other biomedical applications due to their some special properties. The present study aims to prepare a fiber-based nanosolid dispersion system to enhance the bioavailability of curcumin (CUR). CUR-loaded polyvinyl pyrrolidone (CUR@PVP) nanofibers were successfully prepared via electrospinning. Scanning electron microscopy (SEM) was employed to observe the morphology of the nanofibers, and the SEM image showed that the drug-loaded nanofibers were smooth, and no CUR clusters were found on the surface of the nanofibers. The results of X-ray diffraction (XRD) demonstrated that the CUR was evenly distributed in the nanofibers in an amorphous state. Fourier transform infrared (FTIR) spectroscopy analysis indicated that intermolecular hydrogen bonding occurred between the CUR and the polymer matrix. In vitro dissolution profiles showed that CUR@PVP nanofiber could be quickly dissolved in phosphate-buffered saline (PBS) solution, while negligible dissolution was observed in pure CUR sample. Importantly, in vitro cell viability assays and in vivo animal tests revealed that the nanosolid dispersion system dramatically enhanced the bioavailability and showed effective anticancer effect of the CUR.
authors.affiliation: Department of Physical Examination Center, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, People's Republic of China. wangchuan810@126.com.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Spine Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221009, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Pediatric Orthopaedics, Shanghai XinHua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, People's Republic of China.
authors.forename: Zhenkai
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, People's R. China.
authors.forename: He
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, People's R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yan
authors.affiliation: Department of Orthopaedics, Shanghai XinHua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, People's Republic of China. jia_jia_song@hotmail.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Song
authors.affiliation: Institute for Organic and Biomolecular Chemistry, Free University of Berlin, Takustr. 3, 14195, Berlin, Germany.
authors.forename: Nan
authors.initials: N
authors.lastname: Ma
authors.affiliation: Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, People's R. China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhao
keywords: Anticancer; Bioavailability; Curcumin; Electrospinning