title: Lipid profile among girls with systemic lupus erythematosus.
abstract: The aim of the study was to describe biomarkers of lipid metabolism associated with increased cardiovascular risk and their correlation with disease variables and markers of inflammation in adolescent females with systemic lupus erythematosus (SLE). This cross-sectional controlled study evaluated 33 adolescent females with juvenile SLE and 33 healthy controls. Anthropometric data, SLE disease activity index (SLEDAI), medications, proteinuria, ultra-sensitive C-reactive protein (us-CRP), lipid profile (total cholesterol, LDL-c, HDL-c and triglycerides), apolipoproteins A and B (Apo A-I and B), paraoxonase, and myeloperoxidase were evaluated. Median age of the patients and the median disease duration were 16.7 years and 54 months, respectively. SLEDAI scores above 4 were observed in 11 (33.3 %) patients. Moreover, 12 (36.4 %) patients were overweight, and 5 (15.2 %) had low height for age ratios. Dyslipidemia was observed in 13 (39.4 %) patients and in 7 (21.2 %) controls with a decrease in HDL-c concentrations in SLE patients even after adjustment for their nutritional status. In the group with SLE, us-CRP concentrations were inversely correlated with LDL-c/ApoB ratio (p = 0.031). After multivariate regression analysis, the SLE group showed lower concentration of Apo A-I and a decreased LDL-c/ApoB ratio. SLE adolescent females with low disease activity, with preserved kidney function and on low dose of corticosteroids, regardless of nutritional status and food intake, have proatherogenic lipid biomarkers, which may contribute to an increased atherosclerotic risk.
authors.affiliation: Federal University of São Paulo (Universidade Federal de São Paulo), ABC, Rua Ipê, 112, apto 111, São Paulo, SP, 04022-005, Brazil.
authors.forename: Daniele
authors.initials: D
authors.lastname: Machado
authors.affiliation: Federal University of São Paulo (Universidade Federal de São Paulo), ABC, Rua Ipê, 112, apto 111, São Paulo, SP, 04022-005, Brazil.|Medical School (Faculdade de Medicina do ABC), Santo André, Brazil.
authors.forename: Roseli O S
authors.initials: RO
authors.lastname: Sarni
authors.affiliation: Federal University of São Paulo (Universidade Federal de São Paulo), ABC, Rua Ipê, 112, apto 111, São Paulo, SP, 04022-005, Brazil.
authors.forename: Thaís T O
authors.initials: TT
authors.lastname: Abad
authors.affiliation: Federal University of São Paulo (Universidade Federal de São Paulo), ABC, Rua Ipê, 112, apto 111, São Paulo, SP, 04022-005, Brazil.
authors.forename: Simone G L
authors.initials: SG
authors.lastname: Silva
authors.affiliation: Federal University of São Paulo (Universidade Federal de São Paulo), ABC, Rua Ipê, 112, apto 111, São Paulo, SP, 04022-005, Brazil.
authors.forename: Eugênia J B
authors.initials: EJ
authors.lastname: Khazaal
authors.affiliation: Medical School (Faculdade de Medicina do ABC), Santo André, Brazil.
authors.forename: Sonia
authors.initials: S
authors.lastname: Hix
authors.affiliation: Medical School (Faculdade de Medicina do ABC), Santo André, Brazil.
authors.forename: Milena S G
authors.initials: MS
authors.lastname: Correia
authors.affiliation: Federal University of São Paulo (Universidade Federal de São Paulo), ABC, Rua Ipê, 112, apto 111, São Paulo, SP, 04022-005, Brazil.|Medical School (Faculdade de Medicina do ABC), Santo André, Brazil.
authors.forename: Fabíola I
authors.initials: FI
authors.lastname: Suano-Souza
authors.affiliation: Federal University of São Paulo (Universidade Federal de São Paulo), ABC, Rua Ipê, 112, apto 111, São Paulo, SP, 04022-005, Brazil.
authors.forename: Claudio A
authors.initials: CA
authors.lastname: Len
authors.affiliation: Federal University of São Paulo (Universidade Federal de São Paulo), ABC, Rua Ipê, 112, apto 111, São Paulo, SP, 04022-005, Brazil. teterreri@terra.com.br.
authors.forename: Maria Teresa R A
authors.initials: MT
authors.lastname: Terreri
mesh_terms: D000293:Adolescent; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002648:Child; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D001054:Apolipoproteins A; D001055:Apolipoproteins B; D015415:Biomarkers; D014280:Triglycerides; D002784:Cholesterol
keywords: Adolescents; Apolipoprotein A-I; Apolipoprotein B; Dyslipidemia; Systemic lupus erythematosus