title: Electron beam radiotherapy for the management of recurrent extensive ocular surface squamous neoplasia with orbital extension.
abstract: Recurrent extensive ocular surface squamous neoplasia (OSSN) with orbital invasion can be successfully managed with external radiotherapy using electrons resulting in eye and vision salvage. We report a case of right eye recurrent OSSN in an immunocompetent adult Indian male, with extensive orbital involvement. The patient had two previous surgical excisions with recurrent disease. At this stage, conventionally exenteration is considered the treatment modality. However, he was treated with 5040 cGy radiotherapy (15eV electrons) resulting in complete disease regression. At the end of 3 years follow-up, the patient was disease free, maintained a vision of 20/25, with mild dry eye, well-managed with topical lubricants. Extensive OSSN with orbital invasion does not always need exenteration. External beam electron radiotherapy provides a noninvasive cure with organ and vision salvage and should be considered in extensive OSSN not amenable to simple excision biopsies. Long-term studies to evaluate the effect of radiation on such eyes are suggested.
authors.affiliation: Department of Oculoplasty and Ocular Oncology, Axis Eye Clinic, Pune, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Murthy
authors.forename: Himika
authors.initials: H
authors.lastname: Gupta
authors.forename: Rahul
authors.initials: R
authors.lastname: Krishnatry
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Laskar
mesh_terms: D000328:Adult; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000532:radiotherapy*; D003228:Conjunctiva / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D003315:Cornea / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000532:radiotherapy*; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000379:methods*; D014057:Tomography, X-Ray Computed