title: [The action mechanisms of Morus alba leaves extract for the treatment of diabetes based on plasma metabolomics].
abstract: In order to evaluate the effect and mechanism of the mulberry leaf alkaloid, flavones, and polysaccharide intervention on diabetes, the overall metabolite profiling characteristics for the plasma of diabetic mouse was performed by using an ultra-performance liquid chromatography/electrospray-tandem mass spectrometry (UPLC-ESI-MS). The 8 potential biomarkers were found in diabetic mice plasma based on the data of MS/MS characteristics obtained from the UPLC-OrbitrapMS analysis, which mainly involved in sphingolipids, amino acid metabolic pathway. The principal component analysis showed that the normal group and model group were obviously distinguished and implied that metabolic disturbance was happened in diabetic mice plasma. The extracts of mulberry leaf flavonoids, polysaccharide, alkaloid had exhibited the effects of callback function for diabetic mice through regulating the amino acid metabolism and sphingolipid metabolism.
authors.forename: Tao
authors.initials: T
authors.lastname: Ji
authors.forename: Li-li
authors.initials: LL
authors.lastname: Zhang
authors.forename: Xiao-chen
authors.initials: XC
authors.lastname: Huang
authors.forename: Shu-lan
authors.initials: SL
authors.lastname: Su
authors.forename: Zhen
authors.initials: Z
authors.lastname: Ouyang
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Zhu
authors.forename: Sheng
authors.initials: S
authors.lastname: Guo
authors.forename: Er-xin
authors.initials: EX
authors.lastname: Shang
authors.forename: Da-wei
authors.initials: DW
authors.lastname: Qian
authors.forename: Jin-ao
authors.initials: JA
authors.lastname: Duan
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D047309:Flavones / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry; D053858:Metabolic Networks and Pathways; D055432:Metabolomics; D051379:Mice; D031625:Morus / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013107:Sphingolipids / Q000378:metabolism; D053719:Tandem Mass Spectrometry
chemical_list: D000470:Alkaloids; D000596:Amino Acids; D015415:Biomarkers; D047309:Flavones; D005419:Flavonoids; D013107:Sphingolipids