title: Immunohistochemical analysis of CD146 expression in canine skin tumours.
abstract: CD146, a cell adhesion molecule, is overexpressed in a variety of carcinomas, including melanoma, prostate cancer, epithelial ovarian cancer, and breast cancer. The level of expression is directly correlated with tumour progression and metastatic potential. The most commonly affected organ for both neoplastic and non-neoplastic tumours is the skin. The objective of this study is to investigate the immunohistochemical expression of CD146 in canine skin tumours of epidermal or follicular origin in 53 squamous cell carcinomas (SCCs), 9 squamous papillomas, 7 infundibular keratinizing acanthomas (IKA), 21 trichoepitheliomas, 13 trichoblastomas, and 3 pilomatricomas. Immunohistochemical results showed that SCCs (90.6%), squamous papilloma (33.3%), IKA (85.7%), trichoepithelioma (85.9%), trichoblastoma (30.8%) and pilomatricoma (100%), respectively, were positive for CD146. The significant expression of CD146 in SCCs supports its importance as a useful treatment target. CD146 could also be used in differentiation of trichoepithelioma and trichoblastoma.
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan and Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafr El-Sheikh University, Egypt.
authors.forename: S
authors.initials: S
authors.lastname: Abou Asa
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Anwar
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yanai
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan. shiroki@gifu-u.ac.jp.
authors.forename: H
authors.initials: H
authors.lastname: Sakai
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D051929:CD146 Antigen / Q000032:analysis / Q000096:biosynthesis*; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor; D051929:CD146 Antigen