title: Cardiac Chamber Volumetric Assessment Using 3D Ultrasound - A Review.
abstract: When designing clinical trials for testing novel cardiovascular therapies, it is highly relevant to understand what a given technology can provide in terms of information on the physiologic status of the heart and vessels. Ultrasound imaging has traditionally been the modality of choice to study the cardiovascular system as it has an excellent temporal resolution; it operates in real-time; it is very widespread and - not unimportant - it is cheap. Although this modality is mostly known clinically as a two-dimensional technology, it has recently matured into a true three-dimensional imaging technique. In this review paper, an overview is given of the available ultrasound technology for cardiac chamber quantification in terms of volume and function and evidence is given why these parameters are of value when testing the effect of new cardiovascular therapies.
authors.affiliation: Medical Imaging Research Center, University Hospital Gasthuisberg, Herestraat 49 - bus 7003, B-3000 Leuven, Belgium. joao.pedrosa@kuleuven.be.
authors.forename: João
authors.initials: J
authors.lastname: Pedrosa
authors.forename: Daniel
authors.initials: D
authors.lastname: Barbosa
authors.forename: Nuno
authors.initials: N
authors.lastname: Almeida
authors.forename: Olivier
authors.initials: O
authors.lastname: Bernard
authors.forename: Johan
authors.initials: J
authors.lastname: Bosch
authors.forename: Jan
authors.initials: J
authors.lastname: D'hooge
mesh_terms: D002306:Cardiac Volume / Q000502:physiology*; D019560:Echocardiography, Three-Dimensional; D006321:Heart / Q000502:physiology*; D006801:Humans; D016276:Ventricular Function / Q000502:physiology*