title: MDCT features of hepatocellular carcinoma (HCC) in non-cirrhotic liver.
abstract: OBJECTIVE
  To describe the multidetector row computed tomography (MDCT) imaging features of HCC that develops in patients who are free from underlying liver cirrhosis and to determine if the MDCT presentation of this specific tumor differs from that of the more common HCC that develops in patients with liver cirrhosis using a retrospective case-control study.
  
  
  METHODS
  The MDCT examinations of 38 patients with HCC in non-cirrhotic liver (group 1) were quantitatively and qualitatively analyzed and compared to those obtained in 38 patients with HCC in cirrhotic liver (group 2) matched for age and gender. Quantitative and qualitative characteristics of HCC of both groups were compared using univariate analysis.
  
  
  RESULTS
  HCCs were significantly larger in group 1 (81.5mm±55.5) than in group 2 (44.5mm±39.1 SD; P=0.0015). In group 1, HCCs were more frequently single tumors (87%) than in group 2 (37%) (P<0.0001), encapsulated (92% vs. 47% respectively; P<0.0001), had more frequently fatty component (24% vs. 8%, respectively; P=0.0279) and internal hemorrhage (29% vs. 3%, respectively; P=0.0033). No significant differences were found between the two groups for location, hyperenhancement of HCC during the arterial phase, washout during the portal phase, endoluminal portal involvement by HCC, endoportal cruoric thrombus, invasion of adjacent organs and underlying liver steatosis.
  
  
  CONCLUSIONS
  HCC in non-cirrhotic liver are larger than those observed in cirrhotic liver and more frequently present as a single encapsulated tumor. They have the same patterns of enhancement than HCC that develops in cirrhotic liver.
authors.affiliation: Service de radiologie, hôpital Brabois, allée du Morvan, 54511 Vandœuvre-lès-Nancy, France. Electronic address: marielafitte1@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Lafitte
authors.affiliation: Service de radiologie, hôpital Brabois, allée du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: V
authors.initials: V
authors.lastname: Laurent
authors.affiliation: Université Sorbonne Paris-Cité-Diderot Paris 7, 10, avenue de Verdun, 75010 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Soyer
authors.affiliation: Service de radiologie, hôpital Brabois, allée du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: A
authors.initials: A
authors.lastname: Ayav
authors.affiliation: Service de radiologie, hôpital Brabois, allée du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Balaj
authors.affiliation: Service de radiologie, hôpital Brabois, allée du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: I
authors.initials: I
authors.lastname: Petit
authors.affiliation: Service de radiologie, hôpital Brabois, allée du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: G
authors.initials: G
authors.lastname: Hossu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D012189:Retrospective Studies
keywords: Hepatocellular; Hyperenhancement; MDCT; Non-cirrhotic liver; Washout