title: Adipose tissue autophagy status in obesity: Expression and flux--two faces of the picture.
abstract: In the context of elevated prevalence of obesity-associated metabolic diseases in the human population worldwide, interest in the autophagy degradation pathway is increasing, due to close links with energy metabolism, nutritional state, and inflammation. Here we highlight recent data focusing on adipose tissue which demonstrate alterations in fat cell autophagic flux in human obesity.
authors.affiliation: a INSERM UMRS 1166, Sorbonne University, Pierre & Marie Curie, Institute of Cardiometabolism and Nutrition, Pitié-Salpetriere Hospital , Paris , France.
authors.forename: Hedi
authors.initials: H
authors.lastname: Soussi
authors.affiliation: a INSERM UMRS 1166, Sorbonne University, Pierre & Marie Curie, Institute of Cardiometabolism and Nutrition, Pitié-Salpetriere Hospital , Paris , France.
authors.forename: Karine
authors.initials: K
authors.lastname: Clément
authors.affiliation: a INSERM UMRS 1166, Sorbonne University, Pierre & Marie Curie, Institute of Cardiometabolism and Nutrition, Pitié-Salpetriere Hospital , Paris , France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dugail
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D001343:Autophagy; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008954:Models, Biological; D009765:Obesity / Q000473:pathology*
keywords: DAPK2; LC3-II; adipocyte; bariatric surgery; obesity