title: Validation of ion channel targets.
abstract: A prerequisite for a successful target-based drug discovery program is a robust data set that increases confidence in the validation of the molecular target and the therapeutic approach. Given the significant time and resource investment required to carry a drug to market, early selection of targets that can be modulated safely and effectively forms the basis for a strong portfolio and pipeline. In this article we present some of the more useful scientific approaches that can be applied toward the validation of ion channel targets, a molecular family with a history of clinical success in therapeutic areas such as cardiovascular, respiratory, pain and neuroscience.
authors.affiliation: a Icagen, Inc ; Durham , NC USA.
authors.forename: Aaron C
authors.initials: AC
authors.lastname: Gerlach
authors.affiliation: a Icagen, Inc ; Durham , NC USA.
authors.forename: Brett M
authors.initials: BM
authors.lastname: Antonio
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D049990:Membrane Transport Modulators / Q000737:chemistry / Q000494:pharmacology*; D054928:Validation Studies as Topic
chemical_list: D007473:Ion Channels; D049990:Membrane Transport Modulators
keywords: drug discovery; ion channel; modulator; proof of mechanism; validation