title: Chromatin Modifications and Mast Cell Migration in UV-Induced Immunosuppression, an Epigenetic Piece of The Puzzle.
abstract: The migration of dermal mast cells to skin-draining lymph nodes is a key step in UV-induced immunosuppression. Examining the effects of platelet-activating factor (PAF), a phospholipid mediator secreted by keratinocytes following UV exposure, on mast cells, Damiani et al. demonstrate that increased expression of CXCR4 is associated with increased histone acetylation at the promoter of this chemokine receptor gene.
authors.affiliation: Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: rvandoorn@lumc.nl.
authors.forename: Remco
authors.initials: R
authors.lastname: van Doorn
authors.affiliation: Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: de Gruijl
mesh_terms: D044127:Epigenesis, Genetic; D006801:Humans; D008407:Mast Cells / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000502:physiology*
chemical_list: D010972:Platelet Activating Factor