title: [Eukaryotic elongation factor 2 kinase and cancer].
abstract: Eukaryotic elongation factor 2 kinase (eEF2K) is well known as a Ca2+/calmodulin (CaM)-dependent kinase. eEF2K catalyzes the phosphorylation of eEF2 and subsequently inactivates eEF2 by impairing its ability to bind to the ribosome, thereby negatively modulates protein synthesis. The high expression of eEF2K has been found recently in several types of malignancies. As participating in the progress of tumor, eEF2K emerges a potential target for future cancer therapy. The relationship between eEF2K and tumor, and the latest progress of eEF2K inhibitors were summarized in this article.
authors.forename: Gen-zhu
authors.initials: GZ
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Qi
authors.forename: Jing
authors.initials: J
authors.lastname: Li
mesh_terms: D054736:Elongation Factor 2 Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D020652:Peptide Elongation Factor 2 / Q000378:metabolism*; D010766:Phosphorylation
chemical_list: D020652:Peptide Elongation Factor 2; D054736:Elongation Factor 2 Kinase