title: The fat mass and obesity-associated (FTO) gene variant rs9939609 predicts long-term incidence of cardiovascular disease and related death independent of the traditional risk factors.
abstract: OBJECTIVE
  The impact of the rs9939609 FTO variant on cardiovascular events was investigated in the 19-year follow-up of subjects recruited to the OPERA study.
  
  
  RESULTS
  A total of 212 cardiovascular disease (CVD) and 152 coronary heart disease (CHD) events or deaths occurred during follow-up. The logistic regression analysis revealed that among the AA genotype the incidence of CHD (OR 1.905; 95% CI 1.250-2.903, p = 0.001) and CVD (OR 1.849; 1.265-2.702, p = 0.003) events or death was significantly higher when adjusted for age, sex, and study group. After further adjustment with BMI, smoking status, systolic blood pressure, and low-density lipoprotein cholesterol, the higher incidence of CHD and CVD events or death among subjects with the AA genotype remained significant (OR 1.895; p = 0.002 and p = 0.004, respectively). In Cox regression analysis, the AA genotype displayed a higher rate of CVD and CHD death when the model was adjusted for sex, age, and study group (p = 0.006 and p = 0.046). FTO rs9939609 AA genotype improved the C-index of the final predictive model from 0.709 to 0.715. In reclassification analyses, the integrated discrimination index was significant 0.011 (p = 0.010).
  
  
  CONCLUSIONS
  The AA genotype of FTO rs9939609 seems to be associated with a higher risk of CVD, and this phenomenon seems to be independent of the traditional risk factors for atherosclerosis.
authors.affiliation: a Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland.
authors.forename: Meiju
authors.initials: M
authors.lastname: Äijälä
authors.affiliation: a Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland.|b Biocenter Oulu , University of Oulu , Finland.
authors.forename: Justiina
authors.initials: J
authors.lastname: Ronkainen
authors.affiliation: a Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland.|b Biocenter Oulu , University of Oulu , Finland.
authors.forename: Tuija
authors.initials: T
authors.lastname: Huusko
authors.affiliation: a Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland.
authors.forename: Elina
authors.initials: E
authors.lastname: Malo
authors.affiliation: a Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland.|c NordLab Oulu , Oulu University Hospital and Department of Clinical Chemistry, University of Oulu , Finland.
authors.forename: Eeva-Riitta
authors.initials: ER
authors.lastname: Savolainen
authors.affiliation: a Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland.|b Biocenter Oulu , University of Oulu , Finland.
authors.forename: Markku J
authors.initials: MJ
authors.lastname: Savolainen
authors.affiliation: a Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland.|b Biocenter Oulu , University of Oulu , Finland.
authors.forename: Tuire
authors.initials: T
authors.lastname: Salonurmi
authors.affiliation: d Medical Informatics and Statistics Research Group , University of Oulu , Finland.
authors.forename: Risto
authors.initials: R
authors.lastname: Bloigu
authors.affiliation: a Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland.
authors.forename: Y Antero
authors.initials: YA
authors.lastname: Kesäniemi
authors.affiliation: a Medical Research Center Oulu, Oulu University Hospital and University of Oulu , Oulu , Finland.
authors.forename: Olavi
authors.initials: O
authors.lastname: Ukkola
mesh_terms: D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000401:mortality; D005260:Female; D005387:Finland / Q000453:epidemiology; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D015994:Incidence; D008077:Lipoproteins, LDL / Q000378:metabolism; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D008077:Lipoproteins, LDL; D011506:Proteins; D002097:C-Reactive Protein; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: Cardiovascular disease; FTO; mortality