title: Effects of aneuploidy on gene expression: implications for cancer.
abstract: Unbalanced chromosome content, so-called aneuploidy, is a hallmark of cancer cells. Changes in the copy numbers of chromosomes or large chromosomal regions significantly alter the expression of several hundreds of genes that are gained or lost. At the same time, aneuploidy per se affects the transcription of many genes throughout the entire genome, as several pathways are activated or inhibited in response to changes in chromosome copy number. In recent years, a large amount of quantitative genome, transcriptome and proteome data has enabled comparison of the changes in gene expression observed in aneuploid cancer cells, as well as in model aneuploid cells with defined karyotypes. Here, we summarize how aneuploidy shapes gene expression and how it may contribute to the phenotypes of cancer cells.
authors.affiliation: Group Maintenance of Genome Stability, Max Planck Institute of Biochemistry, Martinsried, Germany.|Center for Integrated Protein Science Munich, Ludwig-Maximilian-University Munich, Germany.
authors.forename: Milena
authors.initials: M
authors.lastname: Dürrbaum
authors.affiliation: Group Maintenance of Genome Stability, Max Planck Institute of Biochemistry, Martinsried, Germany.|Center for Integrated Protein Science Munich, Ludwig-Maximilian-University Munich, Germany.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Storchová
mesh_terms: D000782:Aneuploidy; D000818:Animals; D016923:Cell Death; D002875:Chromosomes / Q000235:genetics; D018628:Gene Dosage; D005786:Gene Expression Regulation; D015894:Genome, Human; D006801:Humans; D007621:Karyotyping; D051379:Mice; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011123:Polyploidy; D020543:Proteome / Q000378:metabolism; D059467:Transcriptome
chemical_list: D020543:Proteome
keywords: Aneuploidy; Cancer; Chromosomal Instability; Transcription; Trisomy