title: Role of extracellular vesicles in autoimmune diseases.
abstract: Extracellular vesicles (EVs) consist of exosomes released upon fusion of multivesicular bodies with the cell plasma membrane and microparticles shed directly from the cell membrane of many cell types. EVs can mediate cell-cell communication and are involved in many processes including inflammation, immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. Accumulating evidence reveals that EVs act in the establishment, maintenance and modulation of autoimmune processes among several others involved in cancer and cardiovascular complications. EVs could also present biomedical applications, as disease biomarkers and therapeutic targets or agents for drug delivery.
authors.affiliation: Immunology and Immunogenetic Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France. Electronic address: delphine.turpin@chu-bordeaux.fr.
authors.forename: Delphine
authors.initials: D
authors.lastname: Turpin
authors.affiliation: Rheumatology Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France; UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: marie-elise.truchetet@chu-bordeaux.fr.
authors.forename: Marie-Elise
authors.initials: ME
authors.lastname: Truchetet
authors.affiliation: UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: bfaustin@cirid.org.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Faustin
authors.affiliation: UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: jfaugust@cirid.org.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Augusto
authors.affiliation: Immunology and Immunogenetic Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France; UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: cecile.bordes@chu-bordeaux.fr.
authors.forename: Cécile
authors.initials: C
authors.lastname: Contin-Bordes
authors.affiliation: UMR-5248-CBMN CNRS University of Bordeaux-IBP, allée Geoffroy Saint-Hilaire, 33600 Pessac, France. Electronic address: a.brisson@cbmn.u-bordeaux.fr.
authors.forename: Alain
authors.initials: A
authors.lastname: Brisson
authors.affiliation: Immunology and Immunogenetic Department, Bordeaux Hospital, place Amélie Raba Léon, 33076 Bordeaux Cedex, France; UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address: patrick.blanco@chu-bordeaux.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Blanco
authors.affiliation: UMR-5164 CNRS, CIRID, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France; Internal Medicine and Clinical Immunology Department, Bordeaux Hospital, 1 rue Jean Burguet, 33075 Bordeaux Cedex, France. Electronic address: pierre.duffau@chu-bordeaux.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Duffau
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism; D001692:Biological Transport; D002450:Cell Communication; D000067128:Extracellular Vesicles / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D015398:Signal Transduction
keywords: Autoimmune diseases; Exosomes; Extracellular vesicles; Microparticles; Rheumatoid arthritis; Systemic lupus erythematosus