title: Overview: A New Era of Cancer Genome in Myeloid Malignancies.
abstract: In the Myeloid session of the 30th Nagoya International Cancer Treatment Symposium, three speakers were invited. Prof. Clara Bloomfield emphasized the importance of genetic alterations for the prognostic stratification and treatment of acute myeloid leukemia (AML). Dr. Eytan Stein showed that there are promising anti-leukemia effects of IDH2 inhibitor, AG-221, and DOT1L inhibitor, EPZ-5676, based on early-phase clinical studies. Prof. Seishi Ogawa presented a review of the clonal dynamics of secondary myelodysplastic syndrome (MDS) derived from aplastic anemia (AA). From these presentations, we are confident that molecular analysis-based individualized therapies will be realized within a few years.
authors.affiliation: Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kiyoi
mesh_terms: D000631:Aminopyridines / Q000494:pharmacology / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000150:complications / Q000235:genetics*; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use; D060965:Clonal Evolution / Q000235:genetics; D015894:Genome, Human; D006410:Hematopoiesis / Q000235:genetics; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007521:Isocitrate Dehydrogenase / Q000037:antagonists & inhibitors; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics*; D008780:Methyltransferases / Q000037:antagonists & inhibitors; D058990:Molecular Targeted Therapy; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000188:drug therapy / Q000235:genetics*; D014227:Triazines / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000631:Aminopyridines; D000970:Antineoplastic Agents; D001562:Benzimidazoles; C583893:EPZ-5676; D007166:Immunosuppressive Agents; D014227:Triazines; C000605269:enasidenib; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C473477:DOT1L protein, human; D008780:Methyltransferases; D011495:Histone-Lysine N-Methyltransferase