title: Standardized weaning of infants <32 weeks of gestation from continuous positive airway pressure - a feasibility study.
abstract: The practice of weaning premature infants from continuous positive airway pressure (CPAP) varies considerably and is usually performed without written standards. In this study, the feasibility of a standardized weaning approach was evaluated. In a quasi-experimental design, data from a prospective, post-intervention cohort (n=41) were compared to data from a pre-intervention cohort (n=36). Standardized weaning was feasible but no significant differences in short-term respiratory outcomes were observed. Weaning from CPAP was achieved at 32.1 ± 1.6 (post-intervention) versus 32.5 ± 2.3 weeks (pre-intervention) postmenstrual age. More rigorous, large-scale clinical trials are necessary before firm recommendations on distinct weaning regimens can be made.
authors.affiliation: a Department of Neonatology , University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany , and.
authors.forename: André
authors.initials: A
authors.lastname: Kidszun
authors.affiliation: a Department of Neonatology , University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany , and.
authors.forename: Maren
authors.initials: M
authors.lastname: Plate
authors.affiliation: a Department of Neonatology , University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany , and.
authors.forename: Christine
authors.initials: C
authors.lastname: Arnold
authors.affiliation: a Department of Neonatology , University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany , and.
authors.forename: Julia
authors.initials: J
authors.lastname: Winter
authors.affiliation: b Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany.
authors.forename: Aslihan
authors.initials: A
authors.lastname: Gerhold-Ay
authors.affiliation: a Department of Neonatology , University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany , and.
authors.forename: Eva
authors.initials: E
authors.lastname: Mildenberger
mesh_terms: D045422:Continuous Positive Airway Pressure / Q000592:standards*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D017410:Practice Guidelines as Topic; D013997:Time Factors; D015300:Ventilator Weaning / Q000592:standards*
keywords: Evidence-based medicine; noninvasive respiratory support; prematurity