title: Association Between Trabecular Meshwork Anteroposterior Length and Anterior Chamber Angle Width.
abstract: OBJECTIVE
  To investigate the association between trabecular meshwork anteroposterior length and anterior chamber angle width in nonglaucomatous subjects.
  
  
  METHODS
  Prospective, cross-sectional study.
  
  
  METHODS
  Time-domain and spectral-domain anterior segment optical coherence tomography images for 561 eyes from 366 nonglaucomatous subjects were analyzed to determine trabecular meshwork anteroposterior length and 3 anterior chamber angle width parameters measured at different distances from the scleral spur: angle opening distance at 250 μm (AOD250), 500 μm (AOD500), and 750 μm (AOD750) from the scleral spur; trabecular-iris space area at 500 μm (TISA500) and 750 μm (TISA750) from the scleral spur; angle recess area at 750 μm (ARA750) from the scleral spur. Univariable and multivariable linear mixed-effect regression models, the latter adjusting for age, sex, ethnicity, axial length, and the use of both eyes in the same subject, were used to evaluate the association between trabecular meshwork anteroposterior length and anterior chamber angle width parameters.
  
  
  RESULTS
  Mean trabecular meshwork anteroposterior length was 824.86 ± 181.77 μm. Univariate regression analyses showed a significant positive association between trabecular meshwork anteroposterior length and all anterior chamber angle width parameters: AOD250 (P < .001; β = 335.13), AOD500 (P < .001; β = 271.84), AOD750 (P < .001; β = 202.56), TISA500 (P < .001; β = 780.78), TISA750 (P < .001; β = 449.17), ARA750 (P < .001; β = 381.39). Multivariate regression analyses showed a significant positive association between trabecular meshwork anteroposterior length and all anterior chamber angle width parameters: AOD250 (P = .005; β = 294.02), AOD500 (P = .036; β = 172.94), AOD750 (P = .049; β = 125.58), TISA500 (P = .004; β = 611.51), TISA750 (P = .011; β = 333.96), ARA750 (P < .0001; β = 309.12).
  
  
  CONCLUSIONS
  Wider anterior chamber angle is associated with greater trabecular meshwork anteroposterior length.
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California; Wake Forest University School of Medicine, Winston-Salem, North Carolina.
authors.forename: Roland Y
authors.initials: RY
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California.
authors.forename: Shuai-Chun
authors.initials: SC
authors.lastname: Lin
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California; Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Rebecca I
authors.initials: RI
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California; Department of Ophthalmology, Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil.
authors.forename: Diego T
authors.initials: DT
authors.lastname: Barbosa
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California. Electronic address: LinS@vision.ucsf.edu.
authors.forename: Shan C
authors.initials: SC
authors.lastname: Lin
mesh_terms: D000368:Aged; D000867:Anterior Chamber / Q000033:anatomy & histology*; D058452:Axial Length, Eye / Q000033:anatomy & histology*; D001699:Biometry; D003430:Cross-Sectional Studies; D005260:Female; D006068:Gonioscopy; D006801:Humans; D007498:Iris / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014129:Trabecular Meshwork / Q000033:anatomy & histology*