title: Individual feature maps: a patient-specific analysis tool with applications in temporal lobe epilepsy.
abstract: OBJECTIVE
  MRI-based diagnosis of temporal lobe epilepsy (TLE) can be challenging when pathology is not visually evident due to low image contrast or small lesion size. Computer-assisted analyses are able to detect lesions common in a specific patient population, but most techniques do not address clinically relevant individual pathologies resulting from the heterogeneous etiology of the disease. We propose a novel method to supplement the radiological inspection of TLE patients (n = 15) providing patient-specific quantitative assessment.
  
  
  METHODS
  Regions of interest are defined across the brain and volume, relaxometry, and diffusion features are extracted from them. Statistical comparisons between individual patients and a healthy control group (n = 17) are performed on these features, identifying and visualizing significant differences through individual feature maps. Four maps are created per patient showing differences in intensity, asymmetry, and volume.
  
  
  RESULTS
  Detailed reports were generated per patient. Abnormal hippocampal intensity and volume differences were detected in all patients diagnosed with mesial temporal sclerosis (MTS). Abnormal intensities in the temporal cortex were identified in patients with no MTS. A laterality score correctly distinguished left from right TLE in 12 out of 15 patients.
  
  
  CONCLUSIONS
  The proposed focus on subject-specific quantitative changes has the potential of improving the assessment of TLE patients using MRI techniques, possibly even redefining current imaging protocols for TLE.
authors.affiliation: Imaging Research Laboratories, Robarts Research Institute, London, ON, N6A 5B7, Canada. dcantor@robarts.ca.|Biomedical Engineering Graduate Program, Western University, London, ON, Canada. dcantor@robarts.ca.
authors.forename: Diego
authors.initials: D
authors.lastname: Cantor-Rivera
authors.affiliation: Imaging Research Laboratories, Robarts Research Institute, London, ON, N6A 5B7, Canada.|Biomedical Engineering Graduate Program, Western University, London, ON, Canada.
authors.forename: John S H
authors.initials: JS
authors.lastname: Baxter
authors.affiliation: Imaging Research Laboratories, Robarts Research Institute, London, ON, N6A 5B7, Canada.|Biomedical Engineering Graduate Program, Western University, London, ON, Canada.|Department of Medical Biophysics, Western University, London, ON, Canada.|Epilepsy Program, Department of Clinical Neurological Sciences, Western University - London Health Science Centre, London, ON, Canada.
authors.forename: Sandrine
authors.initials: S
authors.lastname: de Ribaupierrre
authors.affiliation: Epilepsy Program, Department of Clinical Neurological Sciences, Western University - London Health Science Centre, London, ON, Canada.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Lau
authors.affiliation: Department of Medical Biophysics, Western University, London, ON, Canada.|Epilepsy Program, Department of Clinical Neurological Sciences, Western University - London Health Science Centre, London, ON, Canada.
authors.forename: Seyed M
authors.initials: SM
authors.lastname: Mirsattari
authors.affiliation: Imaging Research Laboratories, Robarts Research Institute, London, ON, N6A 5B7, Canada.|Biomedical Engineering Graduate Program, Western University, London, ON, Canada.
authors.forename: Maged
authors.initials: M
authors.lastname: Goubran
authors.affiliation: Epilepsy Program, Department of Clinical Neurological Sciences, Western University - London Health Science Centre, London, ON, Canada.
authors.forename: Jorge G
authors.initials: JG
authors.lastname: Burneo
authors.affiliation: Epilepsy Program, Department of Clinical Neurological Sciences, Western University - London Health Science Centre, London, ON, Canada.
authors.forename: David A
authors.initials: DA
authors.lastname: Steven
authors.affiliation: Imaging Research Laboratories, Robarts Research Institute, London, ON, N6A 5B7, Canada.|Biomedical Engineering Graduate Program, Western University, London, ON, Canada.|Department of Medical Biophysics, Western University, London, ON, Canada.
authors.forename: Terry M
authors.initials: TM
authors.lastname: Peters
authors.affiliation: Imaging Research Laboratories, Robarts Research Institute, London, ON, N6A 5B7, Canada.|Department of Medical Biophysics, Western University, London, ON, Canada.
authors.forename: Ali R
authors.initials: AR
authors.lastname: Khan
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000473:pathology*
keywords: DTI; Diffusion tensor imaging; Mean diffusivity; Patient-specific analysis; Statistical methods; Structural MRI; TLE; Temporal lobe epilepsy; fractional anisotropy; quantitative relaxometry