title: Association between MMP-12-82A/G polymorphism and cancer risk: a meta-analysis.
abstract: BACKGROUND
  Numerous studies have focused on the association between MMP-12-82A>G polymorphism and cancer risk, but produced inconsistent results. Therefore, we performed a meta-analysis of case-control study to evaluate the association of MMP-12-82A>G polymorphism and cancer risk.
  
  
  METHODS
  A systematic literature search was conducted among PubMed, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI) and Wangfang databases updated on May 1st, 2015. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of association between this polymorphism and cancer risk.
  
  
  RESULTS
  A total of seventeen case-control studies with 7,450 cases and 7,348 controls were identified and analyzed. Overall, there was no statistically significant association between MMP-12-82A>G polymorphism and increased risk of cancer under all genetic models. Subgroup analysis by ethnicity observed that there is no strong relationship between MMP-12-82A>G polymorphism and cancer risk among Asian and European populations. Furthermore, stratified analysis based on the source of control revealed no statistically significant association between MMP-12-82A>G polymorphism and cancer risk either in hospital-based or population-based studies. However, when we stratified analysis based on cancer type, significant association was found in ovarian cancer, but not in other types of cancer.
  
  
  CONCLUSIONS
  This meta-analysis suggests that MMP-12-82A>G polymorphism is not significantly associated with overall cancer risk. However, MMP-12-82A>G polymorphism may increase the susceptibility to ovarian cancer.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
authors.forename: Luliang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Periodontology, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
authors.forename: Jinhuan
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
authors.forename: Guolin
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
authors.forename: Boyu
authors.initials: B
authors.lastname: Gu
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
authors.forename: Huirong
authors.initials: H
authors.lastname: Chi
authors.affiliation: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
authors.forename: Fulin
authors.initials: F
authors.lastname: Guo
keywords: Matrix metalloproteinases-12; cancer risk; meta-analysis; polymorphism