title: Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers.
abstract: Cytochrome P450, family 2, subfamily W, polypeptide 1 (CYP2W1) is a newly identified monooxygenase enzyme that is expressed specifically in tumor tissues and during fetal life. Particularly, high expression of CYP2W1 was observed in up to 60% of colorectal cancers and its expression correlated with poor survival. CYP2W1 has been shown to metabolize various endogenous substrates including lysophospholipids and several procarcinogens, such as polycyclic aromatic hydrocarbon. The specific substrate for CYP2W1, however, is currently unknown. Due to its tumor-specific expression and its unique catalytic activities in colorectal cancers, CYP2W1 was deemed as an interesting target in colorectal cancer therapy. This review sought to summarize the current understanding of the CYP2W1 biology and biochemistry, its genetic polymorphisms and cancer risk, and its implication as a tumor-specific diagnostic and therapeutic target.
authors.forename: Felicia Fei-Lei
authors.initials: FF
authors.lastname: Chung
authors.forename: Chun Wai
authors.initials: CW
authors.lastname: Mai
authors.forename: Pei Yuen
authors.initials: PY
authors.lastname: Ng
authors.affiliation: Faculty of Pharmacy, International Medical University, 126 Jalan 19/155B, Bukit Jalil, 57000 Kuala Lumpur, Malaysia. cheeonn_leong@imu.edu.my.
authors.forename: Chee-Onn
authors.initials: CO
authors.lastname: Leong
mesh_terms: D015179:Colorectal Neoplasms / Q000201:enzymology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D000072467:Cytochrome P450 Family 2; D006801:Humans
chemical_list: D003577:Cytochrome P-450 Enzyme System; C509336:CYP2W1 protein, human; D000072467:Cytochrome P450 Family 2