title: Recurrent glioblastoma: Current patterns of care in an Australian population.
abstract: This retrospective population-based survey examined current patterns of care for patients with recurrent glioblastoma (rGBM) who had previously undergone surgery and post-operative therapy at original diagnosis. The patients were identified from the Victorian Cancer Registry (VCR) from 2006 to 2008. Patient demographics, tumour characteristics and oncological management were extracted using a standardised survey by the treating clinicians/VCR staff and results analysed by the VCR. Kaplan-Meier estimates of overall survival (OS) at diagnosis and progression were calculated. A total of 95 patients (48%) received treatment for first recurrence; craniotomy and post-operative treatment (38), craniotomy only (34) and non-surgical treatment (23). Patients receiving treatment at first progression had a higher median OS than those who did not (7 versus 3 months, p<0.0001). All patients progressed after treatment for first progression with 43 patients (45%) receiving treatment at second progression. To our knowledge this is the first population-based pattern of care survey of treatment for rGBM in an era where post-operative "Stupp" chemo-radiation is standard. First and second line therapy for rGBM is common and associated with significant benefit. Treatment generally includes re-resection and/or systemic therapy.
authors.affiliation: Department of Medical Oncology, Austin Health, 145 Studley Road, Heidelberg, Melbourne, VIC 3084, Australia.
authors.forename: Sagun
authors.initials: S
authors.lastname: Parakh
authors.affiliation: Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, VIC, Australia.
authors.forename: Vicky
authors.initials: V
authors.lastname: Thursfield
authors.affiliation: Department of Medical Oncology, Austin Health, 145 Studley Road, Heidelberg, Melbourne, VIC 3084, Australia.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Cher
authors.affiliation: Alfred Health, Prahran, Melbourne, VIC, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Dally
authors.affiliation: Department of Neurosurgery, Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia; Department of Surgery, Melbourne University, Melbourne, VIC, Australia.
authors.forename: Katharine
authors.initials: K
authors.lastname: Drummond
authors.affiliation: St. Vincent's Hospital, Fitzroy, Melbourne, VIC, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Murphy
authors.affiliation: Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Grattan Street, Parkville, VIC, Australia.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rosenthal
authors.affiliation: Department of Medical Oncology, Austin Health, 145 Studley Road, Heidelberg, Melbourne, VIC 3084, Australia; Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, VIC, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC, Australia. Electronic address: Hui.Gan@onjcri.org.au.
authors.forename: Hui K
authors.initials: HK
authors.lastname: Gan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia; D001932:Brain Neoplasms / Q000401:mortality / Q000628:therapy*; D018450:Disease Progression; D005260:Female; D005909:Glioblastoma / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000628:therapy*; D011184:Postoperative Period; D012189:Retrospective Studies
keywords: Chemotherapy; Recurrent glioblastoma; Survival