title: Potential benefits of pentoxifylline on wound healing.
abstract: In this review, potential benefits of pentoxifylline (PTX) on wound healing have been evaluated. All available experimental and clinical studies examined effects of PTX on wound healing have been included. No time limitation was considered and all studies up to writing the manuscript were included. Administration of oral or parenteral PTX showed beneficial effects on the healing of colorectal anastomosis, post burn scar, radiation-induced skin/soft tissue injury, venous ulcers, recurrent aphthous stomatitis and cutaneous/mucocutaneous leishmaniasis. Data regarding effect of PTX on skin flap survival are conflicting. Only few evidences support promising effects of PTX in pressure ulcer, skin developing injury and burn.
authors.affiliation: a Department of Clinical Pharmacy, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Motahareh
authors.initials: M
authors.lastname: Ahmadi
authors.affiliation: a Department of Clinical Pharmacy, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Khalili
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D010431:Pentoxifylline / Q000008:administration & dosage* / Q000494:pharmacology; D003668:Pressure Ulcer / Q000188:drug therapy / Q000473:pathology; D013524:Surgical Flaps / Q000502:physiology; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D014665:Vasodilator Agents; D010431:Pentoxifylline
keywords: Pentoxifylline; healing; wound