title: A review of recent patents on the ASICs as a key drug target.
abstract: Acid-sensing ion channels (ASICs) are scattered various cells of human body. Drugs like amiloride has demonstrated nonspecific antagonism ASICs. Toxins, such as Psalmotoxin-1, have been used in animal models. There are no drugs available in the market whose action mechanism acts through these channels. We revised all patents relating to pharmaceutical formulations of applicability in ASICs. Drugs acting as antagonist in ASIC1 or ASIC3 channels seem to be the most promising targets. Patent data have suggested a variety of approaches for selective ASICs drugs, such as neuroprotective and analgesic. Studies analysis suggested that ASICs are promising targets for new drugs.
authors.forename: Priscila L
authors.initials: PL
authors.lastname: Santos
authors.forename: Adriana G
authors.initials: AG
authors.lastname: Guimarães
authors.forename: Rosana S S
authors.initials: RS
authors.lastname: Barreto
authors.forename: Mairim R
authors.initials: MR
authors.lastname: Serafini
authors.forename: Jullyana S S
authors.initials: JS
authors.lastname: Quintans
authors.affiliation: Department of Physiology, Federal University of Sergipe, Av. Marechal Rondom, Sao Cristovao, Sergipe-Brazil. lucindo@pq.cnpq.br.
authors.forename: Lucindo J
authors.initials: LJ
authors.lastname: Quintans-Júnior
mesh_terms: D062646:Acid Sensing Ion Channel Blockers; D000818:Animals; D000893:Anti-Inflammatory Agents; D002460:Cell Line; D004345:Drug Industry; D006801:Humans; D051379:Mice; D059408:Pain Management; D010330:Patents as Topic
chemical_list: D062646:Acid Sensing Ion Channel Blockers; D000893:Anti-Inflammatory Agents