title: Efficacy of Donepezil for Cognitive Impairments in Familial Hypercholesterolemia: Preclinical Proof of Concept.
authors.affiliation: Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brasil.
authors.forename: Jadna Bogado
authors.initials: JB
authors.lastname: Lopes
authors.affiliation: Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brasil.
authors.forename: Jade
authors.initials: J
authors.lastname: de Oliveira
authors.affiliation: Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brasil.
authors.forename: Daiane Fátima
authors.initials: DF
authors.lastname: Engel
authors.affiliation: Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brasil.
authors.forename: Gabriela Cristina
authors.initials: GC
authors.lastname: de Paula
authors.affiliation: Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brasil.
authors.forename: Eduardo Luiz Gasnhar
authors.initials: EL
authors.lastname: Moreira
authors.affiliation: Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brasil.
authors.forename: Andreza Fabro
authors.initials: AF
authors.lastname: de Bem
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D004192:Discrimination, Psychological / Q000187:drug effects; D004195:Disease Models, Animal; D000077265:Donepezil; D004353:Drug Evaluation, Preclinical; D005106:Exploratory Behavior / Q000187:drug effects; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D007189:Indans / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018697:Nootropic Agents / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D011581:Psychological Tests; D011973:Receptors, LDL / Q000235:genetics / Q000378:metabolism; D013028:Space Perception / Q000187:drug effects
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D011973:Receptors, LDL; D000077265:Donepezil