title: The Effect of Regeneration Techniques on Periapical Surgery With Different Protocols for Different Lesion Types: A Meta-Analysis.
abstract: OBJECTIVE
  To evaluate the effect of regeneration techniques (RTs) on the outcome of periapical surgery with different protocols for different lesion types.
  
  
  METHODS
  PubMed, the Cochrane Library, and Embase were searched from the beginning of time until December 30, 2014. Studies that met the inclusion criteria were systematically evaluated, and a meta-analysis was performed.
  
  
  RESULTS
  Eight randomized controlled trials met the inclusion criteria. A significantly better outcome was found in the combination group (membranes plus bone replacement analogues) (risk ratio [RR], 0.41; 95% confidence interval [CI], 0.22 to 0.77; P = .005) and bone replacement analogue-only group (RR, 0.48; 95% CI, 0.23 to 0.98; P = .04), whereas no significant beneficial effect was found in the membrane-only group (RR, 0.59; 95% CI, 0.29 to 1.17; P = .13). The use of RTs favorably affected the outcome of periapical through-and-through lesions (RR, 0.38; 95% CI, 0.18 to 0.84; P = .02) and large lesions (≥10 mm) (RR, 0.52; 95% CI, 0.28 to 0.97; P = .04), whereas there was no significant benefit of using RTs for 4-wall lesions (RR, 0.54; 95% CI, 0.27 to 1.07; P = .08).
  
  
  CONCLUSIONS
  Both the isolated use of bone replacement analogues and the combination of membranes and bone replacement analogues can improve the outcome of periapical surgery, whereas using membranes alone does not have significantly favorable effects. The use of RTs for through-and-through and large lesions should be recommended.
authors.affiliation: Master Degree Candidate, Department of Endodontics, School and Hospital of Stomatology, Wuhan University, and The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Master Degree Candidate, Department of Endodontics, School and Hospital of Stomatology, Wuhan University, and The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Associate Professor, Department of Endodontics, School and Hospital of Stomatology, Wuhan University, and The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Associate Professor, Department of Preventive Dentistry, School and Hospital of Stomatology, Wuhan University, and The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, China.
authors.forename: Han
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Associate Professor, Department of Endodontics, School and Hospital of Stomatology, Wuhan University, and The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, Wuhan, China. Electronic address: 105633851@qq.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Yan
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery; D015982:Bias; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008567:Membranes, Artificial; D010483:Periapical Diseases / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial