title: Expression of vascular endothelial growth factor and other cytokines in atopic dermatitis, and correlation with clinical features.
abstract: BACKGROUND
  Vascular endothelial growth factor (VEGF) was found increased in the stratum corneum of patients with atopic dermatitis (AD). However, its potential pathogenic role(s) in AD needs further clarification.
  
  
  OBJECTIVE
  The aim of this study was to determine whether VEGF serum levels correlate with other selected cytokine levels and features of AD.
  
  
  METHODS
  VEGF and other cytokine levels were measured in 83 patients with AD and in a control group and then correlated with clinical and laboratory parameters of AD.
  
  
  RESULTS
  The mean serum concentrations of VEGF and tumor necrosis factor α were significantly higher in patients with AD than in the control group, whereas the mean interleukin eight serum level was lower. VEGF concentrations correlated with the severity of AD as expressed by SCORAD index and objective SCORAD.
  
  
  CONCLUSIONS
  VEGF could be regarded as a potentially important mediator in the pathogenesis of AD, as VEGF levels correlate somewhat with AD severity.
authors.affiliation: Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Samochocki
authors.affiliation: Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Bogaczewicz
authors.affiliation: Department of Social Sciences, University of Social Sciences, Lodz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Sysa-Jędrzejowska
authors.affiliation: Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA.|Private Practice, Rutland, VT, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: McCauliffe
authors.affiliation: Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Kontny
authors.affiliation: Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Wozniacka
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000097:blood; D016207:Cytokines / Q000097:blood*; D003876:Dermatitis, Atopic / Q000097:blood*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D019409:Interleukin-15 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D055815:Young Adult
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5; D016207:Cytokines; D019409:Interleukin-15; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D007073:Immunoglobulin E