title: Do Intraocular Pressure Measurements Under Anesthesia Reflect the Awake Condition?
abstract: BACKGROUND
  Anesthesia or sedation is needed when intraocular pressure (IOP) measurement is required in certain circumstances. The effect of different anesthetic regimens on the IOP is still debatable. We aimed to evaluate alterations in the IOP under anesthesia with either propofol or different end-tidal concentrations of sevoflurane, when compared with the awake state.
  
  
  METHODS
  The IOP was measured in both eyes of 20 adult patients undergoing extraocular ophthalmic surgeries at 5 timepoints: before the induction of general anesthesia (under topical anesthesia), after the induction using propofol target-controlled infusion, and under 3 end-tidal concentrations of sevoflurane (0.5%, 2%, and 5%), either in a decreasing (group A) or an increasing (group B) concentration order.
  
  
  RESULTS
  With either propofol or sevoflurane anesthesia, the IOP did not differ significantly from the measurement performed during the awake state (no anesthesia), regardless of the concentration of sevoflurane used (in the range of 0.5% to 5%) or the order of sevoflurane administration (from low to high concentration or vice versa).
  
  
  CONCLUSIONS
  These data suggest that propofol and sevoflurane are valid anesthetic agents for the evaluation of IOP in adults when anesthesia is needed.
authors.affiliation: *Division of Anesthesia, Pain and Critical Care †Department of Ophthalmology, Tel-Aviv Medical Center Affiliated with Sackler Medical School, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Nina
authors.initials: N
authors.lastname: Gofman
authors.forename: Barak
authors.initials: B
authors.lastname: Cohen
authors.forename: Idit
authors.initials: I
authors.lastname: Matot
authors.forename: Anat
authors.initials: A
authors.lastname: Cattan
authors.forename: Gad
authors.initials: G
authors.lastname: Dotan
authors.forename: Chaim
authors.initials: C
authors.lastname: Stolovitch
authors.forename: Noa
authors.initials: N
authors.lastname: Ela-Dalman
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage; D000077149:Sevoflurane; D014065:Tonometry, Ocular; D014851:Wakefulness / Q000502:physiology*
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol