title: Regio- and Stereoselective Synthesis of Sulfur-Bearing Four-Membered Heterocycles: Direct Access to 2,4-Disubstituted Thietane 1-Oxides.
abstract: Starting from readily available C2-substituted thietane 1-oxides, a straightforward synthesis of new C2,C4-disubstituted thietane 1-oxides has been developed by using a lithiation/electrophilic trapping sequence. The chemical and configurational stability of lithiated C2-substituted thietane 1-oxides has been investigated as well as the stereochemical implications for this process. The results demonstrate that a stereoselective functionalization at the C2, C4 positions of a thietane is feasible, leaving intact the four-membered ring.
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" , Via E. Orabona 4, 70125 Bari, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Degennaro
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" , Via E. Orabona 4, 70125 Bari, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Carroccia
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" , Via E. Orabona 4, 70125 Bari, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Parisi
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" , Via E. Orabona 4, 70125 Bari, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Zenzola
authors.affiliation: DICATECh, Politecnico di Bari , Via Orabona 4, 70125 Bari, Italy.|CNR NANOTEC-Istituto di Nanotecnologia , Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100 Lecce, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Romanazzi
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" , Via E. Orabona 4, 70125 Bari, Italy.|CNR, Institute of Crystallography IC-CNR , Amendola, 122/o, 70125 Bari, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Fanelli
authors.affiliation: Department of Chemistry and Pharmacy, University of Sassari , Via Vienna 2, 07100 Sassari, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Pisano
authors.affiliation: Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" , Via E. Orabona 4, 70125 Bari, Italy.
authors.forename: Renzo
authors.initials: R
authors.lastname: Luisi