title: [Effect of Modified Baizhu Powder on Gastrointestinal Functions in Mouse Models with Stomach-cold Functional Dyspepsia].
abstract: OBJECTIVE
  To explore the effect of modified Baizhu (Rhizoma Atractylodis Macrocephalae) powder on the gastrointestinal function in mouse models with stomach-cold functional dyspepsia. Meanwhile,the mouse models were administered with Shihu (dendrobium), a traditional Chinese drug with cold nature and flavour, to explore the way via which it exert its effect on specific symptoms. Methods: Mouse models with stomach-cold functional dyspepsia were established by ice water and ice NaOH. The effects of modified Baizhu powder and dendrobium on mice were observed in terms of water intake, weight change,small intestine propulsion rate, intestinal absorption function, and effects on ghrelin and motilin.
  
  
  RESULTS
  The modified Baizhu powder effectively increased food intake, water intake, body weight (P<0.05) and swimming time (P<0.01), increased the small intestine propulsion rate and serum D-xylose content (P<0.05), and up-regulated ghrelin (P<0.05). Also, it showed a trend to down-regulate the motilin, although the change was not statistically significant (P>0.05). In contrast,the use of Shihu aggravated symptoms in the mouse models. Conclusion: The changes in ghrelin and motilin levels may be the neuro-endocrine mechanisms via which the modified Baizhu powder and Shihu exert their effects on mouse models.
authors.affiliation: Department of Acupuncture and Manipulation,the Second Clinical College of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China 2Department of Orthopaedics,the First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China3Clinical Medicine Teaching and Research Section of Medical Institute of Pingdingshan University,Pingdingshan,Henan 467000,China.
authors.forename: Xu-wen
authors.initials: XW
authors.lastname: Zhang
authors.forename: Chi
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Acupuncture and Manipulation,the Second Clinical College of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China 2Department of Orthopaedics,the First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China3Clinical Medicine Teaching and Research Section of Medical Institute of Pingdingshan University,Pingdingshan,Henan 467000,China.
authors.forename: Xiao-tong
authors.initials: XT
authors.lastname: Wang
authors.affiliation: Department of Acupuncture and Manipulation,the Second Clinical College of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China 2Department of Orthopaedics,the First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China3Clinical Medicine Teaching and Research Section of Medical Institute of Pingdingshan University,Pingdingshan,Henan 467000,China.
authors.forename: Hai-xiong
authors.initials: HX
authors.lastname: Lin
authors.affiliation: Department of Acupuncture and Manipulation,the Second Clinical College of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China 2Department of Orthopaedics,the First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China3Clinical Medicine Teaching and Research Section of Medical Institute of Pingdingshan University,Pingdingshan,Henan 467000,China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.forename: Wan-quan
authors.initials: WQ
authors.lastname: Tang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004415:Dyspepsia; D054439:Ghrelin; D007421:Intestine, Small; D008516:Medicine, Chinese Traditional; D051379:Mice; D009037:Motilin; D011208:Powders; D013270:Stomach
chemical_list: D054439:Ghrelin; D011208:Powders; D009037:Motilin