title: Clinical use of plasma chitotriosidase in severe sepsis.
abstract: Plasma chitotriosidase activity (ChT) was previously proposed to quantify severity of sepsis. In a complex surgical case, with prolonged sepsis and consistently high ChT, we found that the least increased values occurred in stages of extreme illness, with profound hypocholesterolemia. ChT needs better characterization before becoming a reliable biomarker of septic evolution.
authors.affiliation: a a CNR-IASI Center for the Pathophysiology of Shock, Catholic University of the Sacred Heart, Agostino Gemelli Hospital , Rome , Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Chiarla
authors.affiliation: a a CNR-IASI Center for the Pathophysiology of Shock, Catholic University of the Sacred Heart, Agostino Gemelli Hospital , Rome , Italy.
authors.forename: Ivo
authors.initials: I
authors.lastname: Giovannini
authors.affiliation: b b Institute of Pediatrics, Catholic University of the Sacred Heart, Agostino Gemelli Hospital , Rome , Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Antuzzi
authors.affiliation: b b Institute of Pediatrics, Catholic University of the Sacred Heart, Agostino Gemelli Hospital , Rome , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Piras
authors.affiliation: c c Hepatobiliary Surgery Unit (Dept of Surgical Sciences), Catholic University of the Sacred Heart, Agostino Gemelli Hospital , Rome , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ardito
authors.affiliation: c c Hepatobiliary Surgery Unit (Dept of Surgical Sciences), Catholic University of the Sacred Heart, Agostino Gemelli Hospital , Rome , Italy.
authors.forename: Felice
authors.initials: F
authors.lastname: Giuliante
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D008297:Male; D018805:Sepsis / Q000097:blood*
chemical_list: D015415:Biomarkers; D006596:Hexosaminidases; C086400:chitotriosidase
keywords: Critical illness; Hypocholesterolemia; Intensive care; Monitoring; Plasma chitotriosidase; Sepsis