title: Protective Effect of Tetrandrine on Sodium Taurocholate-Induced Severe Acute Pancreatitis.
abstract: Tet is a type of alkaloid extracted from Stephania tetrandra, and it has recently been demonstrated that Tet can protect against inflammation and free radical injury and inhibit the release of inflammatory mediators. The present study was designed to observe the protective effect of Tet on sodium taurocholate-induced severe acute pancreatitis (SAP). The rat model of SAP was induced by retrograde bile duct injection of sodium taurocholate and then treated with Verapamil and Tet. The results showed that Tet can reduce NF-κB activation in pancreas issue, inhibit the SAP cascade, and improve SAP through inducing pancreas acinar cell apoptosis and stabilizing intracellular calcium in the pancreas, thus mitigating the damage to the pancreas. Our study revealed that Tet may reduce systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndromes (MODS) to protect against damage, and these roles may be mediated through the NF-κB pathway to improve the proinflammatory/anti-inflammatory imbalance.
authors.affiliation: Pancreatic Disease Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China ; Clinical Medicine Research Institute, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China ; Department of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, China.
authors.forename: Xian-Lin
authors.initials: XL
authors.lastname: Wu
authors.affiliation: Pancreatic Disease Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China ; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
authors.forename: Jie-Xing
authors.initials: JX
authors.lastname: Li
authors.affiliation: Pancreatic Disease Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China ; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
authors.forename: Zhen-Dong
authors.initials: ZD
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
authors.forename: Da-Sheng
authors.initials: DS
authors.lastname: Liu
authors.affiliation: Department of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, China.
authors.forename: Su-Hong
authors.initials: SH
authors.lastname: Lu
authors.affiliation: Department of Internal Medicine, Nancheng Peoples' Hospital, Dongguan 523071, China.
authors.forename: Kang-Li
authors.initials: KL
authors.lastname: Liu
authors.affiliation: Department of Fetal Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Duan
authors.affiliation: Pancreatic Disease Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China ; Department of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, China ; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Luo