title: Review of clinically accessible methods to determine lean body mass for normalization of standardized uptake values.
abstract: With the routine use of 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) scans, metabolic activity of tumors can be quantitatively assessed through calculation of SUVs. One possible normalization parameter for the standardized uptake value (SUV) is lean body mass (LBM), which is generally calculated through predictive equations based on height and body weight. (Semi-)direct measurements of LBM could provide more accurate results in cancer populations than predictive equations based on healthy populations. In this context, four methods to determine LBM are reviewed: bioelectrical impedance analysis, dual-energy X-ray absorptiometry. CT, and magnetic resonance imaging. These methods were selected based on clinical accessibility and are compared in terms of methodology, precision and accuracy. By assessing each method's specific advantages and limitations, a well-considered choice of method can hopefully lead to more accurate SUVLBM values, hence more accurate quantitative assessment of 18F-FDG PET images.
authors.affiliation: Department of Public Health and Primary Care KU Leuven campus Kortrijk, Kortrijk, Belgium - Hans.Pottel@kuleuven-kulak.be.
authors.forename: Joke
authors.initials: J
authors.lastname: Devriese
authors.forename: Laurence
authors.initials: L
authors.lastname: Beels
authors.forename: Alex
authors.initials: A
authors.lastname: Maes
authors.forename: Christophe
authors.initials: C
authors.lastname: Van De Wiele
authors.forename: Olivier
authors.initials: O
authors.lastname: Gheysens
authors.forename: Hans
authors.initials: H
authors.lastname: Pottel
mesh_terms: D000818:Animals; D016477:Artifacts; D001692:Biological Transport; D001835:Body Weight; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D010808:Physical Examination / Q000379:methods*; D012015:Reference Standards
chemical_list: D019788:Fluorodeoxyglucose F18