title: Nervous System Lyme Disease.
abstract: Nervous system involvement occurs in 10% to 15% of patients infected with the tick-borne spirochetes Borrelia burgdorferi, B afzelii, and B garinii. Peripheral nervous system involvement is common. Central nervous system (CNS) involvement, most commonly presenting with lymphocytic meningitis, causes modest cerebrospinal fluid (CSF) pleocytosis. Parenchymal CNS infection is rare. If the CNS is invaded, however, measuring local production of anti-B burgdorferi antibodies in the CSF provides a useful marker of infection. Most cases of neuroborreliosis can be cured with oral doxycycline; parenteral regimens should be reserved for patients with particularly severe disease.
authors.affiliation: Department of Neurosciences, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA; Sidney Kimmel Medical College of Thomas Jefferson University, 132 South, 10th street, Philadelphia, PA 19107, USA. Electronic address: john.halperin@atlantichealth.org.
authors.forename: John J
authors.initials: JJ
authors.lastname: Halperin
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology
chemical_list: D000907:Antibodies, Bacterial; D004318:Doxycycline
keywords: Diagnosis; Garin Bujadoux Bannwarth syndrome; Lyme disease; Nervous system; Neuroborreliosis; Spinal fluid; Treatment