title: Bronchopulmonary Dysplasia and Chronic Lung Disease: Stem Cell Therapy.
abstract: Bronchopulmonary dysplasia (BPD), a major complication of premature birth, still lacks safe and effective treatment. Mesenchymal stem cells (MSCs) have been proven to ameliorate critical aspects of the BPD pathogenesis. MSCs seem to exert therapeutic effects through the paracrine secretion of anti-inflammatory, antioxidant, antiapoptotic, trophic, and proangiogenic factors. Although these findings are promising, understanding the mechanism of action of MSCs and MSC manufacturing is still evolving. Several aspects can affect the efficacy of MSC therapy. Further research is required to optimize this potentially game-changing treatment but the translation of regenerative cell therapies for patients has begun.
authors.affiliation: Department of Clinical Sciences and Community Health, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Via della Commenda 12, Milan 20122, Italy; Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, 5, Genova 16148, Italy. Electronic address: maria.pierro@mangiagalli.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Pierro
authors.affiliation: Neonatal Intensive Care Unit, MBBM Foundation, San Gerardo Hospital, Via Pergolesi 33, Monza 20900, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Ciarmoli
authors.affiliation: Division of Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada; Regenerative Medicine Program, Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, The Ottawa Hospital, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada; Department of Cellular and Molecular Medicine, Sinclair Institute of Regenerative Medicine, University of Ottawa, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.
authors.forename: Bernard
authors.initials: B
authors.lastname: Thébaud
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001997:Bronchopulmonary Dysplasia / Q000628:therapy*; D002908:Chronic Disease; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008168:Lung / Q000196:embryology* / Q000254:growth & development; D008171:Lung Diseases / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D033581:Stem Cell Transplantation
keywords: Bronchopulmonary dysplasia; Clinical translation; Newborn; Prematurity; Stem cells