title: Neurofibromatosis type 1 and pregnancy: The transformation of a nodular to cystic neurofibroma in the cervical region.
abstract: BACKGROUND
  The peripheral hallmarks of neurofibromatosis type 1 (NF1) are Café au lait and solid nodular neurofibromas. The morphological behavior of these lesions could be susceptible to modification during pregnancy. The present case report describes a case of cystic transformation of a nodular neurofibroma, with progressive growth and mass effect in the anterior cervical region, which was surgically resolved without any complications.
  
  
  METHODS
  A 33-year-old female patient with a known personal history of NF1, with annual control of the peripheral neurofibromas and cerebral and spinal magnetic resonance imaging follow-ups. Under genetic counseling, she decides to get pregnant following all the medical advises. Once the pregnancy is confirmed, she starts to notice the growth of one of them adjacent to the left cervical region. Such neurofibroma presented with the progressive gradual increase and in the last month, she presented dysphagia, dysphonia, and postural pain localized by the mass effect. Once the pregnancy concluded, the microsurgical approach was scheduled for resection of the lesion, where a cystic mass was found within the walls of the neurofibroma. The resection was uneventful.
  
  
  CONCLUSIONS
  The transformation of a nodular to cystic neurofibroma during pregnancy is a very rare presentation, which may exacerbate the clinical symptomatology depending on the topography of the lesion due to the mass effect it may create. This condition may alert to the recommendations and vigilance in patients with NF1, who are pregnant or are planning on a future pregnancy. The neurosurgical resolution in this region is safe and beneficial.
authors.affiliation: Department of Neurosciences, Institute of Translational Neurosciences, CUCS University of Guadalajara, Jalisco, México.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Ramos-Zúñiga
authors.affiliation: Department of Neurosciences, CUCS University of Guadalajara, Jalisco, México.
authors.forename: Daniel Alexander
authors.initials: DA
authors.lastname: Saldaña-Koppel
keywords: Microsurgery; neck dissection; neurofibromatosis type 1; neuropathology; pregnancy