title: Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery.
abstract: A novel siRNA delivery system based on a triblock copolymer with pH and reduction dual-sensitivity was introduced. The polyplex, having high delivery efficiency not dependent on surface charge reversion in response to the pH value of tumor tissue, was used for target gene silencing in cancer therapy.
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. shuaixt@mail.sysu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. shuaixt@mail.sysu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Fang
authors.affiliation: Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Xingsu
authors.initials: X
authors.lastname: Yu
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. shuaixt@mail.sysu.edu.cn.
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Su
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. shuaixt@mail.sysu.edu.cn.
authors.forename: Du
authors.initials: D
authors.lastname: Cheng
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. shuaixt@mail.sysu.edu.cn and Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Xintao
authors.initials: X
authors.lastname: Shuai
mesh_terms: D006801:Humans; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine; D009369:Neoplasms / Q000628:therapy*; D034741:RNA, Small Interfering / Q000008:administration & dosage*
chemical_list: D034741:RNA, Small Interfering