title: Evaluation of mode equivalence of the MSKCC Bowel Function Instrument, LASA Quality of Life, and Subjective Significance Questionnaire items administered by Web, interactive voice response system (IVRS), and paper.
abstract: OBJECTIVE
  To assess the equivalence of patient-reported outcome (PRO) survey responses across Web, interactive voice response system (IVRS), and paper modes of administration.
  
  
  METHODS
  Postoperative colorectal cancer patients with home Web/e-mail and phone were randomly assigned to one of the eight study groups: Groups 1-6 completed the survey via Web, IVRS, and paper, in one of the six possible orders; Groups 7-8 completed the survey twice, either by Web or by IVRS. The 20-item survey, including the MSKCC Bowel Function Instrument (BFI), the LASA Quality of Life (QOL) scale, and the Subjective Significance Questionnaire (SSQ) adapted to bowel function, was completed from home on consecutive days. Mode equivalence was assessed by comparison of mean scores across modes and intraclass correlation coefficients (ICCs) and was compared to the test-retest reliability of Web and IVRS.
  
  
  RESULTS
  Of 170 patients, 157 completed at least one survey and were included in analysis. Patients had mean age 56 (SD = 11), 53% were male, 81% white, 53% colon, and 47% rectal cancer; 78% completed all assigned surveys. Mean scores for BFI total score, BFI subscale scores, LASA QOL, and adapted SSQ varied by mode by less than one-third of a score point. ICCs across mode were: BFI total score (Web-paper = 0.96, Web-IVRS = 0.97, paper-IVRS = 0.97); BFI subscales (range = 0.88-0.98); LASA QOL (Web-paper = 0.98, Web-IVRS = 0.78, paper-IVRS = 0.80); and SSQ (Web-paper = 0.92, Web-IVRS = 0.86, paper-IVRS = 0.79).
  
  
  CONCLUSIONS
  Mode equivalence was demonstrated for the BFI total score, BFI subscales, LASA QOL, and adapted SSQ, supporting the use of multiple modes of PRO data capture in clinical trials.
authors.affiliation: UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Antonia V
authors.initials: AV
authors.lastname: Bennett
authors.affiliation: Memorial Sloan Kettering Cancer Center, 1233 York Avenue, New York, NY, 10065, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Keenoy
authors.affiliation: Memorial Sloan Kettering Cancer Center, 1233 York Avenue, New York, NY, 10065, USA.
authors.forename: Marwan
authors.initials: M
authors.lastname: Shouery
authors.affiliation: UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.|Memorial Sloan Kettering Cancer Center, 1233 York Avenue, New York, NY, 10065, USA.
authors.forename: Ethan
authors.initials: E
authors.lastname: Basch
authors.affiliation: Memorial Sloan Kettering Cancer Center, 1233 York Avenue, New York, NY, 10065, USA. templel@mskcc.org.
authors.forename: Larissa K
authors.initials: LK
authors.lastname: Temple
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D008055:Lipids; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D011184:Postoperative Period; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires / Q000592:standards
chemical_list: D008055:Lipids; C054080:lipid-associated sialic acid; D019158:N-Acetylneuraminic Acid
keywords: Electronic PRO capture; Mode equivalence; Quality of life; Rectal cancer