title: Paediatric acute myeloid leukaemia with the t(7;12)(q36;p13) rearrangement: a review of the biological and clinical management aspects.
abstract: The presence of chromosomal abnormalities is one of the most important criteria for leukaemia diagnosis and management. Infant leukaemia is a rare disease that affects children in their first year of life. It has been estimated that approximately one third of infants with acute myeloid leukaemia harbour the t(7;12)(q36;p13) rearrangement in their leukaemic blasts. However, the WHO classification of acute myeloid leukaemia does not yet include the t(7;12) as a separate entity among the different genetic subtypes, although the presence of this chromosomal abnormality has been associated with an extremely poor clinical outcome. Currently, there is no consensus treatment for t(7;12) leukaemia patients. However, with the inferior outcome with the standard induction therapy, stem cell transplantation may offer a better chance for disease control. A better insight into the chromosome biology of this entity might shed some light into the pathogenic mechanisms arising from this chromosomal translocation, that at present are not fully understood. Further work is needed to improve our understanding of the molecular and genetic basis of this disorder. This will hopefully open some grounds for possible tailored treatment for this subset of very young patients with inferior disease outcome. This review aims at highlighting the cytogenetic features that characterise the t(7;12) leukaemias for a better detection of the abnormality in the diagnostic setting. We also review treatment and clinical outcome in the cases reported to date.
authors.affiliation: Leukaemia and Chromosome Research Laboratory, Division of Biosciences, Brunel University London, Middlesex, UB8 3PH UK.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Tosi
authors.affiliation: Leukaemia and Chromosome Research Laboratory, Division of Biosciences, Brunel University London, Middlesex, UB8 3PH UK.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Mostafa Kamel
authors.affiliation: Leukaemia and Chromosome Research Laboratory, Division of Biosciences, Brunel University London, Middlesex, UB8 3PH UK.
authors.forename: Temitayo
authors.initials: T
authors.lastname: Owoka
authors.affiliation: Dipartimento di Scienze Biologiche, Geologiche e Ambientali, Sezione di Biologia Animale, University of Catania, Catania, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Federico
authors.affiliation: Division of Pediatric Oncology, Blood and Marrow Transplant, Alberta Children's Hospital, University of Calgary, Calgary, Canada.
authors.forename: Tony H
authors.initials: TH
authors.lastname: Truong
authors.affiliation: Dipartimento di Scienze Biologiche, Geologiche e Ambientali, Sezione di Biologia Animale, University of Catania, Catania, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Saccone
keywords: Acute myeloid leukaemia; Chromosomal abnormalities; Clinical outcome; HLXB9 gene; Paediatric leukaemia; t(7;12) translocation