title: Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs.
abstract: Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery. Much effort has been made to incorporate hydrophilic molecules in hydrogels in the field of drug delivery, while loading of hydrophobic drugs has not been vastly studied. However, in recent years, research has also been conducted on incorporating hydrophobic molecules within hydrogel matrices for achieving a steady release of drugs to treat various ailments. Here, we summarize the types of hydrogels used as drug delivery vehicles, various methods to incorporate hydrophobic molecules in hydrogel matrices, and the potential therapeutic applications of hydrogels in cancer.
authors.affiliation: Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, USA. Matthew.Mckenzie@stlcop.edu.
authors.forename: Matthew
authors.initials: M
authors.lastname: McKenzie
authors.affiliation: Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, USA. David.Betts@stlcop.edu.
authors.forename: David
authors.initials: D
authors.lastname: Betts
authors.affiliation: Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, USA. Amy.Suh@stlcop.edu.
authors.forename: Amy
authors.initials: A
authors.lastname: Suh
authors.affiliation: Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, USA. Kathryn.Bui@stlcop.edu.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Bui
authors.affiliation: Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, USA. Doyoung.Kim@stlcop.edu.
authors.forename: London Doyoung
authors.initials: LD
authors.lastname: Kim
authors.affiliation: Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, USA. Hyunah.Cho@stlcop.edu.
authors.forename: Hyunah
authors.initials: H
authors.lastname: Cho
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D009369:Neoplasms / Q000188:drug therapy; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013696:Temperature; D014867:Water
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D020100:Hydrogels; D004364:Pharmaceutical Preparations; D011108:Polymers; D014867:Water
keywords: block copolymers; hydrogels; hydrophobic drugs; thermosensitive