title: Fluorescent N-Doped Carbon Dots as in Vitro and in Vivo Nanothermometer.
abstract: The fluorescent N-doped carbon dots (N-CDs) obtained from C3N4 emit strong blue fluorescence, which is stable with different ionic strengths and time. The fluorescence intensity of N-CDs decreases with the temperature increasing, while it can recover to the initial one with the temperature decreasing. It is an accurate linear response of fluorescence intensity to temperature, which may be attributed to the synergistic effect of abundant oxygen-containing functional groups and hydrogen bonds. Further experiments also demonstrate that N-CDs can serve as effective in vitro and in vivo fluorescence-based nanothermometer.
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Weiqian
authors.initials: W
authors.lastname: Kong
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Manman
authors.initials: M
authors.lastname: Yang
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Shanghai Advanced Research Institute, Chinese Academy of Sciences , Shanghai 20050, China.
authors.forename: Zhongyang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Canadian Light Source , Saskatoon, Saskatchewan S7N2 V3, Canada.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Canadian Light Source , Saskatoon, Saskatchewan S7N2 V3, Canada.
authors.forename: Tsun-Kong
authors.initials: TK
authors.lastname: Sham
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Shuit-Tong
authors.initials: ST
authors.lastname: Lee
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren'ai Road, Suzhou 215123, Jiangsu, People's Republic of China.
authors.forename: Zhenhui
authors.initials: Z
authors.lastname: Kang
mesh_terms: D002244:Carbon / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D045663:Quantum Dots; D013821:Thermometers
chemical_list: D002244:Carbon
keywords: N-doped carbon dots; cellular imaging; in vivo imaging; linear response; nanothermometer; temperature-dependent fluorescence