title: [The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis].
abstract: In our clinical practice, we observed high interleukin-6 (IL-6) levels in gram-negative sepsis.
  
  
  
  To investigate the relationship between IL-6 and C-reactive protein (CRP) levels and early determination of neonatal sepsis of gram-negative or gram-positive aetiology.
  
  
  
  White blood cell count, IL-6 and CRP levels were compared among different groups.
  
  
  
  Gram-negative, gram-positive and fungal infection groups consisted of 73, 82 and 15 patients, respectively. The optimal cut-off levels of IL-6 between gram-negative and gram-positive fungal infection groups were 202 and 57 pg/ml. The fungal infection group had higher CRP levels than gram-negative and positive infection groups.
  
  
  
  To our knowledge, this is the largest reported study aiming at determining of IL-6 cut-off levels to differentiate neonatal sepsis aetiology. Gram-negative microorganisms led to 10 fold higher IL-6 production. The evaluation of IL-6 and CRP is useful to diagnose and also differentiate neonatal sepsis aetiology.
authors.affiliation: Neonatologia, Hospital Universitario y de Investigación en Ginecologia Etlik Zubeyde Hanim, Ankara.
authors.forename: Istemi H
authors.initials: IH
authors.lastname: Celik
authors.affiliation: Neonatologia, Medipol Üniversitesi, Estambul.
authors.forename: Gamze
authors.initials: G
authors.lastname: Demirel
authors.affiliation: Neonatologia, Hospital Universitario Maternal Zekai Tahir Burak, Ankara.
authors.forename: Nurdan
authors.initials: N
authors.lastname: Uras
authors.affiliation: Neonatologia, Hospital Universitario Maternal Zekai Tahir Burak, Ankara.
authors.forename: Erife S
authors.initials: ES
authors.lastname: Oguz
authors.affiliation: Neonatologia, Facultad de Medicina, Ankara Üniversitesi, Ankara.
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.affiliation: Neonatologia, Facultad de Medicina, Ankara Üniversitesi, Ankara.
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D016470:Bacteremia / Q000175:diagnosis; D002097:C-Reactive Protein / Q000032:analysis*; D016469:Fungemia / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood*; D007958:Leukocyte Count; D000071074:Neonatal Sepsis / Q000175:diagnosis* / Q000209:etiology
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein