title: Association of the NOTCH4 Gene Polymorphism rs204993 with Schizophrenia in the Chinese Han Population.
abstract: NOTCH4 regulates signaling pathways associated with neuronal maturation, a process involved in the development and patterning of the central nervous system. The NOTCH4 gene has also been identified as a possible susceptibility gene for schizophrenia (SCZ). The objective of this study was to examine the relationship between NOTCH4 polymorphisms and SCZ in the Chinese Han population. The rs2071287 and rs204993 polymorphisms of the NOTCH4 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent. Single SNP allele-, genotype-, and gender-specific associations were analyzed using different models (i.e., additive, dominant, and recessive models). This association study revealed that the rs204993 polymorphism is significantly associated with susceptibility for SCZ and that the AA genotype of rs204993 is associated with a higher risk for SCZ (P = 0.027; OR = 1.460; 95% CI, 1.043-2.054). Our data are consistent with those obtained in previous studies that suggested that rs204993 is associated with SCZ and that the AA genotype of rs204993 demonstrates a higher risk. Further large-scale association analyses in Han Chinese populations are warranted.
authors.affiliation: College of Medicine & Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Bao
authors.initials: B
authors.lastname: Zhang
authors.affiliation: College of Medicine & Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Qian Rui
authors.initials: QR
authors.lastname: Fan
authors.affiliation: College of Medicine & Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Wen Hao
authors.initials: WH
authors.lastname: Li
authors.affiliation: Department of Food and Biological Engineering, Henan Industry & Trade Vocational College, Henan, Zhengzhou 451191, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Lu
authors.affiliation: College of Medicine & Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Dong Ke
authors.initials: DK
authors.lastname: Fu
authors.affiliation: College of Medicine & Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Yan Jie
authors.initials: YJ
authors.lastname: Kang
authors.affiliation: College of Medicine & Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: College of Medicine & Forensic, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Xiao Peng
authors.initials: XP
authors.lastname: Wen
authors.affiliation: Department of Stomatology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Da Xu
authors.initials: DX
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D000074562:Receptor, Notch4; D051880:Receptors, Notch / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
chemical_list: C106075:NOTCH4 protein, human; D011518:Proto-Oncogene Proteins; D000074562:Receptor, Notch4; D051880:Receptors, Notch