title: Sleep Disturbances in Schizophrenia.
abstract: Sleep disturbances are prevalent in patients with schizophrenia and play a critical role in the morbidity and mortality associated with the illness. Subjective and objective assessments of sleep in patients with schizophrenia have identified certain consistent findings. Findings related to the sleep structure abnormalities have shown correlations with important clinical aspects of the illness. Disruption of specific neurotransmitter systems and dysregulation of clock genes may play a role in the pathophysiology of schizophrenia-related sleep disturbances. Antipsychotic medications play an important role in the treatment of sleep disturbances in these patients and have an impact on their sleep structure.
authors.affiliation: Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-6415, USA. Electronic address: jkamath@uchc.edu.
authors.forename: Jayesh
authors.initials: J
authors.lastname: Kamath
authors.affiliation: Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-6415, USA.
authors.forename: Sundeep
authors.initials: S
authors.lastname: Virdi
authors.affiliation: Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-6415, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Winokur
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D019468:Disease Management; D006801:Humans; D012559:Schizophrenia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012893:Sleep Wake Disorders / Q000139:chemically induced / Q000150:complications* / Q000188:drug therapy / Q000628:therapy
chemical_list: D014150:Antipsychotic Agents
keywords: Antipsychotic medication; Clinical correlates; Clock genes; Neurotransmitter; Polysomnography; Schizophrenia; Sleep disturbances