title: Circulating microRNAs and Outcome in Patients with Acute Heart Failure.
abstract: BACKGROUND
  The biomarker value of circulating microRNAs (miRNAs) has been extensively addressed in patients with acute coronary syndrome. However, prognostic performances of miRNAs in patients with acute heart failure (AHF) has received less attention.
  
  
  METHODS
  A test cohort of 294 patients with acute dyspnea (236 AHF and 58 non-AHF) and 44 patients with stable chronic heart failure (CHF), and an independent validation cohort of 711 AHF patients, were used. Admission levels of miR-1/-21/-23/-126/-423-5p were assessed in plasma samples.
  
  
  RESULTS
  In the test cohort, admission levels of miR-1 were lower in AHF and stable CHF patients compared to non-AHF patients (p = 0.0016). Levels of miR-126 and miR-423-5p were lower in AHF and in non-AHF patients compared to stable CHF patients (both p<0.001). Interestingly, admission levels of miR-423-5p were lower in patients who were re-admitted to the hospital in the year following the index hospitalization compared to patients who were not (p = 0.0001). Adjusted odds ratio [95% confidence interval] for one-year readmission was 0.70 [0.53-0.93] for miR-423-5p (p = 0.01). In the validation cohort, admission levels of miR-423-5p predicted 1-year mortality with an adjusted odds ratio [95% confidence interval] of 0.54 [0.36-0.82], p = 0.004. Patients within the lowest quartile of miR-423-5p were at high risk of long-term mortality (p = 0.02).
  
  
  CONCLUSIONS
  In AHF patients, low circulating levels of miR-423-5p at presentation are associated with a poor long-term outcome. This study supports the value of miR-423-5p as a prognostic biomarker of AHF.
authors.affiliation: Department of Cardiology, EA3920, University Hospital, Besançon, France.|UMRS 942 Inserm, University Paris Diderot, Paris, France.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Seronde
authors.affiliation: Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Vausort
authors.affiliation: UMRS 942 Inserm, University Paris Diderot, Paris, France.|Department of Anesthesiology and Critical Care Saint Louis-Lariboisière Hospital, Paris, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Gayat
authors.affiliation: Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg.
authors.forename: Emeline
authors.initials: E
authors.lastname: Goretti
authors.affiliation: University of Leicester and National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
authors.forename: Leong L
authors.initials: LL
authors.lastname: Ng
authors.affiliation: University of Leicester and National Institute for Health Research, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
authors.forename: Iain B
authors.initials: IB
authors.lastname: Squire
authors.affiliation: UMRS 942 Inserm, University Paris Diderot, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vodovar
authors.affiliation: UMRS 942 Inserm, University Paris Diderot, Paris, France.
authors.forename: Malha
authors.initials: M
authors.lastname: Sadoune
authors.affiliation: UMRS 942 Inserm, University Paris Diderot, Paris, France.
authors.forename: Jane-Lise
authors.initials: JL
authors.lastname: Samuel
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Thum
authors.affiliation: UMRS 942 Inserm, University Paris Diderot, Paris, France.|Department of Cardiology, Lariboisière Hospital, Paris, France.
authors.forename: Alain Cohen
authors.initials: AC
authors.lastname: Solal
authors.affiliation: UMRS 942 Inserm, University Paris Diderot, Paris, France.|Department of Emergency Medicine, Lariboisière Hospital, Paris, France.
authors.forename: Said
authors.initials: S
authors.lastname: Laribi
authors.affiliation: UMRS 942 Inserm, University Paris Diderot, Paris, France.|Department of Emergency Medicine, Lariboisière Hospital, Paris, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Plaisance
authors.affiliation: Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Wagner
authors.affiliation: UMRS 942 Inserm, University Paris Diderot, Paris, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Mebazaa
authors.affiliation: Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Devaux
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D004417:Dyspnea / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C548900:MIRN423 microRNA, human; D035683:MicroRNAs