title: Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease.
abstract: Selenium (Se) is essential for both brain development and male fertility. Male mice lacking two key genes involved in Se metabolism (Scly(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures that manifest beginning in early adulthood. We demonstrate that prepubescent castration of Scly(-/-)Sepp1(-/-) mice prevents behavioral deficits, attenuates neurodegeneration, rescues maturation of GABAergic inhibition, and increases brain selenoprotein levels. Moreover, castration also yields similar neuroprotective benefits to Sepp1(-/-) and wild-type mice challenged with Se-deficient diets. Our data show that, under Se-compromised conditions, the brain and testes compete for Se utilization, with concomitant effects on neurodevelopment and neurodegeneration.
  
  
  CONCLUSIONS
  Selenium is an essential trace element that promotes male fertility and brain function. Herein, we report that prepubescent castration provides neuroprotection by increasing selenium-dependent antioxidant activity in the brain, revealing a competition between the brain and testes for selenium utilization. These findings provide novel insight into the interaction of sex and oxidative stress upon the developing brain and have potentially significant implications for the prevention of neurodevelopmental disorders characterized by aberrant excitatory/inhibitory balance, such as schizophrenia and epilepsy.
authors.affiliation: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, and mwpitts@hawaii.edu.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Pitts
authors.affiliation: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, and.
authors.forename: Penny M
authors.initials: PM
authors.lastname: Kremer
authors.affiliation: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, and.
authors.forename: Ann C
authors.initials: AC
authors.lastname: Hashimoto
authors.affiliation: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, and.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Torres
authors.affiliation: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, and.
authors.forename: China N
authors.initials: CN
authors.lastname: Byrns
authors.affiliation: Department of Medicine and Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Williams
authors.affiliation: Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, and.
authors.forename: Marla J
authors.initials: MJ
authors.lastname: Berry
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D002369:Castration; D016291:Dizocilpine Maleate / Q000494:pharmacology; D020195:Epilepsy, Reflex / Q000235:genetics; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008190:Lyases / Q000235:genetics / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000378:metabolism; D065886:Neurodevelopmental Disorders / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D012643:Selenium / Q000378:metabolism*; D051149:Selenoprotein P / Q000235:genetics / Q000378:metabolism*; D012737:Sex Factors; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D051149:Selenoprotein P; D014157:Transcription Factors; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1; D016291:Dizocilpine Maleate; D008190:Lyases; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1; C034278:selenocysteine lyase; D012643:Selenium
keywords: neurodegeneration; neurodevelopment; oxidative stress; parvalbumin interneurons; selenium; sex differences