title: Pulmonary Hypertension and Vascular Abnormalities in Bronchopulmonary Dysplasia.
abstract: Despite advances in the care of preterm infants, these infants remain at risk bronchopulmonary dysplasia (BPD), which results in prolonged need for supplemental oxygen, recurrent respiratory exacerbations, and exercise intolerance. Recent investigations have highlighted the important contribution of the developing pulmonary circulation to lung development, showing that these infants are also at risk for pulmonary vascular disease (PVD), including pulmonary hypertension (PH) and pulmonary vascular abnormalities. Several epidemiologic studies have delineated the incidence of PH in preterm infants and the impact on outcomes. These studies have also highlighted gaps in the understanding of PVD in BPD.
authors.affiliation: Section of Pediatric Critical Care, Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado, School of Medicine, 13121 East 17th Avenue, MS8414, Aurora, CO 80045, USA. Electronic address: peter.mourani@childrenscolorado.org.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Mourani
authors.affiliation: Section of Pulmonary Medicine, Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado, School of Medicine, Mail Stop B395, 13123 East 16th Avenue, Aurora, CO 80045, USA.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Abman
mesh_terms: D000280:Administration, Inhalation; D001997:Bronchopulmonary Dysplasia / Q000150:complications / Q000503:physiopathology*; D004452:Echocardiography; D045462:Endothelium-Dependent Relaxing Factors / Q000627:therapeutic use; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D007231:Infant, Newborn; D007234:Infant, Premature; D009569:Nitric Oxide / Q000627:therapeutic use; D011652:Pulmonary Circulation / Q000502:physiology; D014652:Vascular Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D045462:Endothelium-Dependent Relaxing Factors; D009569:Nitric Oxide
keywords: Bronchopulmonary dysplasia; Echocardiogram; Inhaled nitric oxide; Pulmonary hypertension; Pulmonary vascular disease