title: TSH receptor antibody titers measured with a third-generation assay did not reflect the activity of Graves' ophthalmopathy in untreated Japanese Graves' disease patients.
abstract: TSH receptor antibody (TRAb) titer has been reported to be correlated with Graves' ophthalmopathy (GO). However, the correlation between GO activity and TRAb titer assessed with a third-generation assay has not been reported. We enrolled 238 untreated Graves' disease patients who came to the outpatient clinic of Ito Hospital and 28 patients who were euthyroid. All of the patients were assessed for GO by an ophthalmologist within 3 months of their initial visit to Ito Hospital. Clinical activity score (CAS), short inversion time inversion recovery (STIR), and sum of the maximum external orbital muscle areas (SEOMA) on a frontal sectional magnetic resonance imaging (MRI). The TRAb titer was significantly higher in patients with inactive ophthalmopathy (the inactive-GO group) than in patients with active ophthalmopathy (the active-GO group) (17.7 ± 13.5 IU/L vs. 13.0 ± 13.1 IU/L, p=0.0082). The SEOMA values were not correlated with TRAb titer. The prevalence of active-GO was higher in euthyroid patients than in hyperthyroid patients although the difference was not significant. In conclusion, TRAb titer measured with a third-generation assay dose not correlate with GO activity based on MRI findings in untreated Graves' disease patients, and the prevalence of active-GO is higher in euthyroid patients with lower TRAb titers than in hyperthyroid patients.
authors.affiliation: Ito Hospital, Tokyo, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Mukasa
authors.forename: Jaeduk
authors.initials: J
authors.lastname: Yoshimura Noh
authors.forename: Ai
authors.initials: A
authors.lastname: Kouzaki
authors.forename: Hidemi
authors.initials: H
authors.lastname: Ohye
authors.forename: Yo
authors.initials: Y
authors.lastname: Kunii
authors.forename: Natsuko
authors.initials: N
authors.lastname: Watanabe
authors.forename: Ai
authors.initials: A
authors.lastname: Yoshihara
authors.forename: Masako
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Miho
authors.initials: M
authors.lastname: Suzuki
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018450:Disease Progression; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000150:complications / Q000473:pathology; D049970:Graves Ophthalmopathy / Q000097:blood* / Q000175:diagnosis*; D006403:Hematologic Tests / Q000379:methods*; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000032:analysis* / Q000097:blood*; D007564:Japan; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
chemical_list: D018828:Immunoglobulins, Thyroid-Stimulating; C094372:thyrotropin-binding inhibitory immunoglobulin