title: TCF-1 at the Tfh and Th1 Divergence.
abstract: Three recent studies provide new insight into the mechanisms that promote the differentiation of antigen-primed T cells into the follicular helper T (Tfh) lineage, revealing a key role for the transcription factor TCF-1 in the regulation of the Bcl6-Blimp-1 axis that mediates the divergence between the Tfh and the Th1 lineages.
authors.affiliation: Molecular Immunomodulation Laboratory, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Molecular Immunomodulation Laboratory, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Victoria 3800, Australia. Electronic address: Di.Yu@monash.edu.
authors.forename: Di
authors.initials: D
authors.lastname: Yu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D054380:Receptors, CXCR5 / Q000502:physiology; D051822:T Cell Transcription Factor 1 / Q000378:metabolism*; D018417:Th1 Cells / Q000378:metabolism* / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D054380:Receptors, CXCR5; D051822:T Cell Transcription Factor 1; D014157:Transcription Factors