title: [AWAKE CRANIOTOMY: IN SEARCH FOR OPTIMAL SEDATION].
abstract: Awake craniotomy is a "gold standard"for intraoperative brain language mapping. One of the main anesthetic challenge of awake craniotomy is providing of optimal sedation for initial stages of intervention. The goal of this study was comparison of different technics of anesthesia for awake craniotomy. Materials and methods: 162 operations were divided in 4 groups: 76 cases with propofol sedation (2-4mg/kg/h) without airway protection; 11 cases with propofol sedation (4-5 mg/kg/h) with MV via LMA; 36 cases of xenon anesthesia; and 39 cases with dexmedetomidine sedation without airway protection. Results and discussion: brain language mapping was successful in 90% of cases. There was no difference between groups in successfulness of brain mapping. However in the first group respiratory complications were more frequent. Three other technics were more safer Xenon anesthesia was associated with ultrafast awakening for mapping (5±1 min). Dexmedetomidine sedation provided high hemodynamic and respiratory stability during the procedure.
authors.forename: A S
authors.initials: AS
authors.lastname: Kulikova
authors.forename: D A
authors.initials: DA
authors.lastname: Sel'kov
authors.forename: G L
authors.initials: GL
authors.lastname: Kobyakov
authors.forename: A V
authors.initials: AV
authors.lastname: Shmigel'skiy
authors.forename: A Yu
authors.initials: AY
authors.lastname: Lubnin
mesh_terms: D000328:Adult; D016292:Procedural Sedation / Q000009:adverse effects / Q000379:methods*; D003399:Craniotomy / Q000009:adverse effects / Q000379:methods*; D020927:Dexmedetomidine; D006801:Humans; D017214:Laryngeal Masks; D016343:Monitoring, Intraoperative; D011183:Postoperative Complications / Q000453:epidemiology; D015742:Propofol; D012121:Respiration, Artificial; D014978:Xenon
chemical_list: D014978:Xenon; D020927:Dexmedetomidine; D015742:Propofol