title: [dFOXO Transcription Factor Regulates Juvenile Hormone Metabolism in Drosophila melanogaster Females].
abstract: dFOXO transcription factor is a component of the insulin/insulin-like growth factor signaling pathway in Drosophila. Juvenile hormone negatively regulates dFOXO gene expression. In the present work, the effect of hypomorphic dFOXO mutation on juvenile hormone metabolism under normal and stressing conditions and on D. melanogaster female resistance to thermal stress was studied. It was demonstrated that dFOXO mutation in D. melanogaster females induces (1) an increase in the level of juvenile hormone degradation and in the intensity of the response of the juvenile hormone metabolism system to thermal stress and (2) a decrease in thermal stress resistance. These parameters are indicators of the level of juvenile hormone synthesis and indicate its decrease in females with decreased dFOXO expression. Thus, the presence of feedback in the regulation of dFOXO gene expression by juvenile hormone was established for the first time.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Rauschenbach
authors.forename: E K
authors.initials: EK
authors.lastname: Karpova
authors.forename: N E
authors.initials: NE
authors.lastname: Gruntenko
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000096:biosynthesis* / Q000235:genetics; D004331:Drosophila melanogaster; D005260:Female; D051858:Forkhead Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation; D018869:Heat-Shock Response; D007605:Juvenile Hormones / Q000235:genetics / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; C477334:FOXO protein, Drosophila; D051858:Forkhead Transcription Factors; D007605:Juvenile Hormones