title: First description of cervical intradural thymoma metastasis.
abstract: Thymoma and thymic carcinoma are rare epithelial tumors, which originate from the thymus gland. According to the World Health Organization there are "organotypic" (types A, AB, B1, B2, and B3) and "non-organotypic" (thymic carcinomas) thymomas. Type B3 thymomas are aggressive tumors, which can metastasize. Due to the rarity of these lesions, only 7 cases of extradural metastasis are described in the literature. We report the first and unique case of a man with cervical intradural B3 thymoma metastasis. A 46-year-old man underwent thymoma surgical removal. The year after the procedure he was treated for a parietal pleura metastasis. In 2006 he underwent cervical-dorsal extradural metastasis removal and C5-Th1 stabilization. Seven years after he came to our observation complaining left cervicobrachialgia and a reduction of strength of the left arm. He underwent a cervical spine magnetic resonance imaging, which showed a new lesion at the C5-C7 level. The patient underwent a surgery for the intradural B3 thymoma metastasis. Neurological symptoms improved although the removal was subtotal. He went through postoperative radiation therapy with further mass reduction. Spinal metastases are extremely rare. To date, only 7 cases of spinal extradural metastasis have been described in the literature. This is the first case of spinal intradural metastasis. Early individuation of these tumors and surgical treatment improve neurological outcome in patients with spinal cord compression. A multimodal treatment including neoadjuvant chemotherapy, surgery and postoperative radiation therapy seems to improve survival in patients with metastatic thymoma.
authors.affiliation: Nicola Marotta, Cristina Mancarella, Davide Colistra, Alessandro Landi, Demo Eugenio Dugoni, Roberto Delfini, Department of Neurology and Psychiatry, Division of Neurosurgery, University of Rome "Sapienza", 00161 Rome, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Marotta
authors.affiliation: Nicola Marotta, Cristina Mancarella, Davide Colistra, Alessandro Landi, Demo Eugenio Dugoni, Roberto Delfini, Department of Neurology and Psychiatry, Division of Neurosurgery, University of Rome "Sapienza", 00161 Rome, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mancarella
authors.affiliation: Nicola Marotta, Cristina Mancarella, Davide Colistra, Alessandro Landi, Demo Eugenio Dugoni, Roberto Delfini, Department of Neurology and Psychiatry, Division of Neurosurgery, University of Rome "Sapienza", 00161 Rome, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Colistra
authors.affiliation: Nicola Marotta, Cristina Mancarella, Davide Colistra, Alessandro Landi, Demo Eugenio Dugoni, Roberto Delfini, Department of Neurology and Psychiatry, Division of Neurosurgery, University of Rome "Sapienza", 00161 Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Landi
authors.affiliation: Nicola Marotta, Cristina Mancarella, Davide Colistra, Alessandro Landi, Demo Eugenio Dugoni, Roberto Delfini, Department of Neurology and Psychiatry, Division of Neurosurgery, University of Rome "Sapienza", 00161 Rome, Italy.
authors.forename: Demo Eugenio
authors.initials: DE
authors.lastname: Dugoni
authors.affiliation: Nicola Marotta, Cristina Mancarella, Davide Colistra, Alessandro Landi, Demo Eugenio Dugoni, Roberto Delfini, Department of Neurology and Psychiatry, Division of Neurosurgery, University of Rome "Sapienza", 00161 Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Delfini
keywords: Intradural lesion; Metastasis; Spinal surgery; Spinal tumor; Thymoma