title: Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: randomized multicenter split-mouth clinical trial.
abstract: BACKGROUND
  Impacted third molar removal is a routine procedure in oral and maxillofacial surgery. Platelet-rich fibrin (PRF) is a second generation platelet concentration which is produced by simplified protocol. The aim of this study was to assess the effectiveness of PRF in the healing process by evaluating the changes in pain and swelling after third molar surgery.
  
  
  METHODS
  Fifty-six patients (23 male, 33 female) who provide the inclusion criteria were selected to participate in this study. The evaluation of the facial swelling was performed by using a horizontal and vertical guide. The pain was evaluated in the postoperative period using a visual analog scale (VAS) of 100 mm.
  
  
  RESULTS
  Horizontal and vertical measurements showed more swelling at the control side (without PRF) in 3th day postoperatively (p < 0.05). There were no statistically significant differences regarding pain among the groups.
  
  
  CONCLUSIONS
  As a conclusion, PRF seems to be effectiveness on postoperative horizontal swelling after third molar surgery. PRF could be used on a routine basis after third molar extraction surgery.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Ufuk University, Ankara, Turkey. ozkanozgul@yahoo.com.
authors.forename: Ozkan
authors.initials: O
authors.lastname: Ozgul
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Senses
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Trakya University, Edirne, Turkey.
authors.forename: Nilay
authors.initials: N
authors.lastname: Er
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Tekin
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
authors.forename: Hakan Hıfzi
authors.initials: HH
authors.lastname: Tuz
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, Kayseri,, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Alkan
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Ismail Doruk
authors.initials: ID
authors.lastname: Kocyigit
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Fethi
authors.initials: F
authors.lastname: Atil
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets; D004487:Edema / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D014081:Tooth Extraction / Q000009:adverse effects*; D014095:Tooth, Impacted / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005337:Fibrin