title: Melanoma: Clinical Presentations.
abstract: The malignant cell in melanoma is the melanocyte. Because melanocytes are located in the basal layer of the epidermis, melanoma is most commonly seen on the skin. However, melanoma can also arise on mucosal surfaces such as the oral cavity, the upper gastrointestinal mucosa, the genital mucosa, as well as the uveal tract of the eye and leptomeninges. Melanomas tend to be pigmented but can also present as pink or red lesions. They can mimic benign or other malignant skin lesions. This chapter presents the spectrum of typical and less typical presentations of melanoma, as well as patterns of spread. It is divided into (1) cutaneous lesions; (2) patterns of regional spread, (3) non-cutaneous lesions; and (4) distant metastases.
authors.affiliation: Departments of Dermatology and Medicine, Yale University School of Medicine, New Haven, USA.
authors.forename: Nour
authors.initials: N
authors.lastname: Kibbi
authors.affiliation: Departments of Dermatology and Medicine, Yale University School of Medicine, New Haven, USA. harriet.kluger@yale.edu.
authors.forename: Harriet
authors.initials: H
authors.lastname: Kluger
authors.affiliation: Departments of Dermatology and Medicine, Yale University School of Medicine, New Haven, USA.
authors.forename: Jennifer Nam
authors.initials: JN
authors.lastname: Choi
mesh_terms: D006801:Humans; D008545:Melanoma / Q000276:immunology / Q000473:pathology* / Q000556:secondary; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology; D014604:Uveal Neoplasms / Q000473:pathology
keywords: Atypical pigmented cutaneous lesions; Melanoma of unknown primary site; Non-cutaneous melanoma