title: Controlled Delivery of Chemopreventive Agents by Polymeric Implants.
abstract: The clinical development of cancer chemopreventive agents has been hampered by poor oral bioavailability issue. Several compounds have low aqueous solubility and undergo extensive first pass metabolism following oral dosing. To overcome this limitation, we developed polymeric implants from biodegradable ε-polycaprolactone (PCL) that can deliver both lipophilic as well as hydrophilic compounds. Implants furnish controlled release of compounds for long duration and provide dose-dependent release. The rate of release in vitro correlated well with the in vivo release. The polymeric implant technology thus overcomes the oral bioavailability issues, lowers the total required dose and minimizes or eliminates toxicity generally associated with high doses.
authors.affiliation: James Graham Brown Cancer Center, University of Louisville, 580 S. Preston St., #304B, Louisville, KY, 40202, USA.|Department of Medicine, University of Louisville, Louisville, KY, 40202, USA.
authors.forename: Farrukh
authors.initials: F
authors.lastname: Aqil
authors.affiliation: James Graham Brown Cancer Center, University of Louisville, 580 S. Preston Street, Delia Baxter II, Room 304E, Louisville, KY, 40202, USA. rcgupta@louisville.edu.|Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA. rcgupta@louisville.edu.
authors.forename: Ramesh C
authors.initials: RC
authors.lastname: Gupta
mesh_terms: D002626:Chemistry, Pharmaceutical; D018890:Chemoprevention; D004337:Drug Carriers; D065546:Drug Liberation; D057927:Hydrophobic and Hydrophilic Interactions; D011091:Polyesters; D019736:Prostheses and Implants
chemical_list: D004337:Drug Carriers; D011091:Polyesters; C016240:polycaprolactone
keywords: Bioavailability; Controlled release; Drug delivery; Polycaprolactone; Polymeric implants