title: Control of telomerase action at human telomeres.
abstract: Recent progress has greatly increased the understanding of telomere-bound shelterin proteins and the telomerase holoenzyme, predominantly as separate complexes. Pioneering studies have begun to investigate the requirements for shelterin-telomerase interaction. From this vantage point, focusing on human cells, we review and discuss models for how telomerase and shelterin subunits coordinate to achieve balanced telomere-length homeostasis.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.|Berkeley Stem Cell Center, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Dirk
authors.initials: D
authors.lastname: Hockemeyer
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.|Berkeley Stem Cell Center, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Collins
mesh_terms: D004247:DNA / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D000089804:Shelterin Complex; D019098:Telomerase / Q000378:metabolism*; D059505:Telomere Homeostasis; D034501:Telomere-Binding Proteins / Q000378:metabolism*
chemical_list: D000089804:Shelterin Complex; D034501:Telomere-Binding Proteins; D004247:DNA; D019098:Telomerase