title: Long noncoding RNAs in regulation of human breast cancer.
abstract: Less than 2% of the human genome DNA is composed of protein-coding genes, although the majority of the human genome is transcribed, indicating the transcripts mostly are noncoding RNAs. Those noncoding RNAs with length between 200 nt and 200 kb are categorized as long noncoding RNA (lncRNA). Around 30 000 lncRNAs have been predicted or identified, although little is known regarding the regulatory function for a vast majority of these sequences. Emerging evidence demonstrated that lncRNAs play crucial roles in regulation of many cancer types, including breast cancer, serving as oncogenes or tumor suppressors. Aberrant and differential expression of lncRNA in breast cancer has been frequently reported. Their regulation of breast cancer is still the beginning to be elucidated. This review collected those experimentally validated lncRNAs in human breast cancer, summarizing their biological function as well as the regulatory mechanism. In addition, the potential of lncRNAs as biomarkers for better diagnosis or therapeutic targets for cancer treatment was discussed.
authors.forename: Guangxue
authors.initials: G
authors.lastname: Wang
authors.forename: Cuicui
authors.initials: C
authors.lastname: Liu
authors.forename: Shengqiong
authors.initials: S
authors.lastname: Deng
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.forename: Tieyan
authors.initials: T
authors.lastname: Li
authors.forename: Shanshan
authors.initials: S
authors.lastname: Qiao
authors.forename: Lei
authors.initials: L
authors.lastname: Shen
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jinhui
authors.initials: J
authors.lastname: Lü
authors.forename: Lingyu
authors.initials: L
authors.lastname: Meng
authors.forename: Chunli
authors.initials: C
authors.lastname: Liang
authors.forename: Zuoren
authors.initials: Z
authors.lastname: Yu
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: breast cancer; long noncoding RNA; oncogene; tumor suppressor