title: Therapeutic application of hydrogen sulfide donors: the potential and challenges.
abstract: Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been considered a toxic gas and environment hazard. However, evidences show that H2S plays a great role in many physiological and pathological activities, and it exhibits different effects when applied at various doses. In this review, we summarize the chemistry and biomedical applications of H2S-releasing compounds, including inorganic salts, phosphorodithioate derivatives, derivatives of Allium sativum extracts, derivatives of thioaminoacids, and derivatives of antiinflammatory drugs.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China.|Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China.
authors.forename: Qingxun
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China. zhuyz@fudan.edu.cn.
authors.forename: Yizhun
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005737:Garlic; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D010710:Phosphates / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D012492:Salts / Q000627:therapeutic use; D013440:Sulfides / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D010710:Phosphates; D010936:Plant Extracts; D012492:Salts; D013440:Sulfides; C083120:phosphorodithioic acid; D006862:Hydrogen Sulfide
keywords: cancer; cardiovascular; hydrogen sulfide; hypertension