title: [THE ROLE OF HEME-CONTAINING GLOBINS IN HYPOXIC NO-SIGNALING OF VERTEBRATE CELLS].
abstract: Nitric oxide is one of the most important signaling molecule of living organisms. It may be produced by two ways: from arginine by means of NO-syntases and from nitrite by means of nitrite reductases. The last way is realized mostly at hypoxic state of organisms and heme-containing globins of vertebrates (hemoglobin, myoglobin, cytoglobin, neuroglobin) mediate the transformation of NO2 into NO by means of their nitrite reductase activities. Hypoxic NO-signaling depends on oxygen concentration and is important for exercise, vascular hypoxic vasodilation, myocardial preconditioning and angiogenesis. Data of scientific literature of last 15 years show that the nitrite-reductase activity of heme-containing globins was used for oxygen sensing and ROS/RNS defence at early stages of life evolution.
authors.forename: N V
authors.initials: NV
authors.lastname: Kuleva
authors.forename: I E
authors.initials: IE
authors.lastname: Krasovskaya
mesh_terms: D000818:Animals; D005075:Biological Evolution; D000078842:Cytoglobin; D005914:Globins / Q000737:chemistry / Q000378:metabolism*; D006418:Heme / Q000737:chemistry / Q000378:metabolism; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D019157:Ischemic Preconditioning, Myocardial; D009211:Myoglobin / Q000737:chemistry / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*; D000078787:Neuroglobin; D009569:Nitric Oxide / Q000378:metabolism*; D009572:Nitrite Reductases / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D014664:Vasodilation / Q000502:physiology
chemical_list: C000627265:CYGB protein, human; D000078842:Cytoglobin; D006454:Hemoglobins; D009211:Myoglobin; D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D009569:Nitric Oxide; D006418:Heme; D005914:Globins; D009572:Nitrite Reductases