title: Salivary Biomarkers in the Control of Mosquito-Borne Diseases.
abstract: Vector control remains the most effective measure to prevent the transmission of mosquito-borne diseases. However, the classical entomo-parasitological methods used to evaluate the human exposure to mosquito bites and the effectiveness of control strategies are indirect, labor intensive, and lack sensitivity in low exposure/transmission areas. Therefore, they are limited in their accuracy and widespread use. Studying the human antibody response against the mosquito salivary proteins has provided new biomarkers for a direct and accurate evaluation of the human exposure to mosquito bites, at community and individual levels. In this review, we discuss the development, applications and limits of these biomarkers applied to Aedes- and Anopheles-borne diseases.
authors.affiliation: Institut de Recherche pour le Développement, Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE) UM63: CNRS7278-IRD 198-INSERM U1095 Campus IRD-UCAD, BP 1386, Dakar 18524, Sénégal. souleymane.doucoure@ird.fr.
authors.forename: Souleymane
authors.initials: S
authors.lastname: Doucoure
authors.affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. papa.drame@nih.gov.
authors.forename: Papa Makhtar
authors.initials: PM
authors.lastname: Drame
keywords: biomarker; control; exposure; mosquito; salivary-proteins