title: Impulsivity trait in the early symptomatic BACHD transgenic rat model of Huntington disease.
abstract: Impulsivity trait was characterized in 3-5 months old BACHD rats, a transgenic model of Huntington disease, using (1) the delay discounting task to assess cognitive/choice impulsivity, and (2) the Differential Reinforcement of Low Rate of Responding task to evaluate motor/action impulsivity. Transgenic animals showed a high level of choice impulsivity and, to a lesser extent, action impulsivity. Our results provide the first evidence that the transgenic BACHD rat (TG5 line) displays impulsivity disorder as early as 3 months old, as described in early symptomatic HD patients, thus adding to the face validity of the rat model.
authors.affiliation: Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany; IMPRS for Cognitive and Systems Neuroscience, University of Tuebingen, Tuebingen, Germany.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Manfré
authors.affiliation: Paris-Saclay Institute of Neuroscience (Neuro-PSI), UMR 9197, Université Paris-Sud, Orsay F-91405, France; CNRS, Orsay F-91405, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Doyère
authors.affiliation: Paris-Saclay Institute of Neuroscience (Neuro-PSI), UMR 9197, Université Paris-Sud, Orsay F-91405, France; CNRS, Orsay F-91405, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Bossi
authors.affiliation: Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Riess
authors.affiliation: Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany.
authors.forename: Huu Phuc
authors.initials: HP
authors.lastname: Nguyen
authors.affiliation: Paris-Saclay Institute of Neuroscience (Neuro-PSI), UMR 9197, Université Paris-Sud, Orsay F-91405, France; CNRS, Orsay F-91405, France. Electronic address: nicole.elmassioui@u-psud.fr.
authors.forename: Nicole
authors.initials: N
authors.lastname: El Massioui
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D003657:Decision Making; D004195:Disease Models, Animal; D006816:Huntington Disease / Q000523:psychology*; D007175:Impulsive Behavior / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D055647:Rats, Transgenic
keywords: Decision making; Executive functions; Huntington disease; Impulsivity; Transgenic rats