title: The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength.
abstract: BACKGROUND
  Ergogenic aides are widely used by fitness enthusiasts and athletes to increase performance. Alpha glycerylphosphorylcholine (A-GPC) has demonstrated some initial promise in changing explosive performance. The purpose of the present investigation was to determine if 6 days of supplementation with A-GPC would augment isometric force production compared to a placebo.
  
  
  METHODS
  Thirteen college-aged males (Means ± SD; Age: 21.9 ± 2.2 years, Height: 180.3 ± 7.7 cm, Weight: 87.6 ± 15.6 kg; VO2 max: 40.08 ± 7.23 ml O2*Kg(-1)*min(-1), Body Fat: 17.5 ± 4.6%) gave written informed consent to participate in the study. The study was a double blind, placebo controlled, cross-over design. The participants reported to the lab for an initial visit where they were familiarized with the isometric mid thigh pull in a custom squat cage on a force platform and upper body isometric test against a high frequency load cell, and baseline measurements were taken for both. The participant then consumed either 600 mg per day of A-GPC or placebo and at the end of 6 days performed isometric mid thigh pulls and an upper body isometric test. A one-week washout period was used before the participants' baseline was re-measured and crossed over to the other treatment.
  
  
  RESULTS
  The A-GPC treatment resulted in significantly greater isometric mid thigh pull peak force change from baseline (t = 1.76, p = 0.044) compared with placebo (A-GPC: 98.8. ± 236.9 N vs Placebo: -39.0 ± 170.9 N). For the upper body test the A-GPC treatment trended towards greater change from baseline force production (A-GPC: 50.9 ± 67.2 N Placebo: -14.9 ± 114.9 N) but failed to obtain statistical significance (t = 1.16, p = 0.127).
  
  
  CONCLUSIONS
  A-GPC is effective at increasing lower body force production after 6 days of supplementation. Sport performance coaches can consider adding A-GPC to the diet of speed and power athletes to enhance muscle performance.
authors.affiliation: School of Kinesiology, University of Louisiana at Lafayette, Lafayette, LA 70503 USA.
authors.forename: David
authors.identifier: 0000-0001-8273-1373
authors.initials: D
authors.lastname: Bellar
authors.affiliation: School of Kinesiology, University of Louisiana at Lafayette, Lafayette, LA 70503 USA.
authors.forename: Nina R
authors.initials: NR
authors.lastname: LeBlanc
authors.affiliation: School of Kinesiology, University of Louisiana at Lafayette, Lafayette, LA 70503 USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Campbell
mesh_terms: D000704:Analysis of Variance; D056352:Athletes; D054874:Athletic Performance; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D005080:Exercise Test; D005997:Glycerylphosphorylcholine / Q000494:pharmacology*; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects*; D008145:Louisiana / Q000453:epidemiology; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects*; D053580:Muscle Strength / Q000187:drug effects*; D005082:Physical Exertion; D015203:Reproducibility of Results; D064133:Sports Nutritional Physiological Phenomena; D013647:Task Performance and Analysis; D013848:Thigh; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D005997:Glycerylphosphorylcholine
keywords: Alpha glycerylphosphorylcholine; Human performance; Sport supplements; Strength