title: Cancer stem cells in laryngeal cancer: what we know.
abstract: Cancer stem cells (CSCs) are a group of cells with eternal life or infinite self-renewal ability, which have high migrating, infiltrative, and metastatic abilities. Though CSCs only account for a small proportion in tumors, the high resistance to traditional therapy exempts them from therapy killing and thus they can reconstruct tumors. Previous studies found that heterogeneity of cancer cells extensively exists in head and neck cancers. Our current knowledge, about CSCs in the laryngeal cancer (LC), largely depends on head and neck studies. Given the lack of systematic data about CSCs in LC, we propose a review of the literature, reporting the evidences of CSCs in tumorigenesis of LC, with the purpose to provide new insights into the prevention and/or treatment of laryngeal carcinoma.
authors.affiliation: Department Organs of Sense, ENT Section, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Greco
authors.affiliation: Department of Surgical Science, Advanced Technology in Surgery, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. mariaidarizzo@gmail.com.
authors.forename: Maria Ida
authors.initials: MI
authors.lastname: Rizzo
authors.affiliation: Department of Surgical Science, Advanced Technology in Surgery, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: De Virgilio
authors.affiliation: Department Organs of Sense, ENT Section, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gallo
authors.affiliation: Department Organs of Sense, ENT Section, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fusconi
authors.affiliation: Department Organs of Sense, ENT Section, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pagliuca
authors.affiliation: Department Organs of Sense, ENT Section, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Martellucci
authors.affiliation: Department Organs of Sense, ENT Section, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Turchetta
authors.affiliation: Department Organs of Sense, ENT Section, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: De Vincentiis
mesh_terms: D000071916:AC133 Antigen / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000818:Animals; D063646:Carcinogenesis; D015687:Cell Hypoxia; D002471:Cell Transformation, Neoplastic; D058750:Epithelial-Mesenchymal Transition; D005347:Fibroblasts; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D018960:Hyaluronan Receptors; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000502:physiology; D059016:Tumor Microenvironment
chemical_list: D000071916:AC133 Antigen; D018960:Hyaluronan Receptors; D000444:Aldehyde Dehydrogenase
keywords: Cancer stem cells; Epithelial-to-mesenchymal transition; Laryngeal carcinoma; Side population; Stemness markers