title: Serological markers of hepatitis B and C in patients with HIV/AIDS and active tuberculosis.
abstract: Infection with hepatitis B virus (HBV) and C virus (HCV) are common in patients with HIV/AIDS and tuberculosis (TB). This is a cross-sectional study with patients infected with HIV/AIDS and active TB in Recife, Brazil, aiming to verify the prevalence of markers for HBV: antibody to hepatitis B core antigen (anti-HBc); and HCV: antibody to hepatitis C virus (anti-HCV) by chemiluminescence, and to identify the frequency of associated factors. Data were collected through questionnaires, and blood was drawn from patients for analysis. We used the chi-square test and the Fisher exact test when necessary. We conducted a bivariate logistic regression analysis and the magnitude of the associations was expressed as odds ratio (OR) with a confidence interval of 95%. Among 166 patients studied with HIV/AIDS and active TB, anti-HBc was positive in 61 patients [36.7%; 95%CI (29.4-44.6%)] and anti-HCV in 11[6.6%; 95%CI (3.4-11.5%)]. In the logistic regression analysis, male sex, and age ≥40 years were independent factors associated with the occurrence of anti-HBc. In conclusion, we verified a high frequency of HBV contact marker and a low frequency of HCV markers in patients with HIV/AIDS and TB in Recife.
authors.affiliation: Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.
authors.forename: Carolline
authors.initials: C
authors.lastname: Araújo-Mariz
authors.affiliation: Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.
authors.forename: Edmundo Pessoa
authors.initials: EP
authors.lastname: Lopes
authors.affiliation: Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.|Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brazil.
authors.forename: Ricardo A A
authors.initials: RA
authors.lastname: Ximenes
authors.affiliation: Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.
authors.forename: Heloísa R
authors.initials: HR
authors.lastname: Lacerda
authors.affiliation: Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brazil.
authors.forename: Demócrito B
authors.initials: DB
authors.lastname: Miranda-Filho
authors.affiliation: Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brazil.
authors.forename: Ulisses R
authors.initials: UR
authors.lastname: Montarroyos
authors.affiliation: Hospital das Clínicas de Pernambuco, Universidade Federal de Pernambuco, Recife, Brazil.
authors.forename: Silvana
authors.initials: S
authors.lastname: Barreto
authors.affiliation: Laboratório de Virologia, Laboratório Central de Pernambuco - LACEN/PE, Recife, Brazil.
authors.forename: Daniela Medeiros
authors.initials: DM
authors.lastname: Salustiano
authors.affiliation: Departamento de Saúde Coletiva, Centro de Pesquisas Aggeu Magalhães/FIOCRUZ, Recife, Brazil.
authors.forename: Maria Fátima Pessoa Militão
authors.initials: MF
authors.lastname: Albuquerque
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology / Q000821:virology; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood; D006512:Hepatitis B Core Antigens / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011795:Surveys and Questionnaires; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies
keywords: HIV/Aids; hepatitis B; hepatitis C; tuberculosis