title: VEGFR2 Gene Polymorphism Correlates with Deep Venous Thrombosis Risk in Chinese Han Population.
abstract: OBJECTIVE
  To investigate the correlations between three vascular endothelial growth factor 2 (VEGFR2) gene polymorphisms, +1192C>T, +1719T>A, and -604T>C, and deep venous thrombosis (DVT) in Chinese Han population.
  
  
  METHODS
  We conducted a case-control study, between September 2009 and September 2012, in a Chinese Han population with onset of lower extremity DVT. A total of 135 patients were enrolled in the case group and 156 healthy individuals in the control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the genotype and allele frequencies of the VEGFR2 gene polymorphisms +1192C>T, +1719T>A, and -604T>C. Haplotype analyses were conducted with SHEsis program. Logistic regression was used to detect the risk factors of DVT. Outpatient review and telephone follow-up were conducted to analyze the long-term treatment of DVT patients.
  
  
  RESULTS
  The allele and genotype frequencies of -604T>C VEGFR2 polymorphism exhibited significant differences between the case and control groups (both p < 0.05). Haplotype analyses showed remarkable differences between the case and control groups in the distribution frequency of TAC and CTT haplotypes in the VEGFR2 gene (both p < 0.05). Logistic regression analysis showed independent correlation between the incidence of DVT and TAC haplotype in the VEGFR2 gene (p < 0.05). In addition, the TAC haplotype may be a risk factor for DVT treatment failure.
  
  
  CONCLUSIONS
  Our findings suggest that the VEGFR2 gene -604T>C polymorphism and TAC haplotype are associated with DVT, and the TAC haplotype might affect the efficacy of long-term treatment of DVT patients.
authors.affiliation: 1 Department of Vascular Surgery, Jining No. 1 People's Hospital , Jining, People's Republic of China .
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: 1 Department of Vascular Surgery, Jining No. 1 People's Hospital , Jining, People's Republic of China .
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Wang
authors.affiliation: 1 Department of Vascular Surgery, Jining No. 1 People's Hospital , Jining, People's Republic of China .
authors.forename: Tao
authors.initials: T
authors.lastname: Jian
authors.affiliation: 1 Department of Vascular Surgery, Jining No. 1 People's Hospital , Jining, People's Republic of China .
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Qin
authors.affiliation: 1 Department of Vascular Surgery, Jining No. 1 People's Hospital , Jining, People's Republic of China .
authors.forename: Fei
authors.initials: F
authors.lastname: Xu
authors.affiliation: 1 Department of Vascular Surgery, Jining No. 1 People's Hospital , Jining, People's Republic of China .
authors.forename: Zhen-Lei
authors.initials: ZL
authors.lastname: Xin
authors.affiliation: 2 Operation Room, Jining No. 1 People's Hospital , Jining, People's Republic of China .
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Wang
authors.affiliation: 1 Department of Vascular Surgery, Jining No. 1 People's Hospital , Jining, People's Republic of China .
authors.forename: Mi
authors.initials: M
authors.lastname: Zhang
authors.affiliation: 2 Operation Room, Jining No. 1 People's Hospital , Jining, People's Republic of China .
authors.forename: Hui-Jun
authors.initials: HJ
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D002681:China / Q000208:ethnology; D005260:Female; D005500:Follow-Up Studies; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D017211:Treatment Failure; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics*; D020246:Venous Thrombosis / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics*; D014859:Warfarin / Q000008:administration & dosage
chemical_list: D014859:Warfarin; C000588866:KDR protein, human; D040301:Vascular Endothelial Growth Factor Receptor-2