title: Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract from Camellia euphlebia Merr. ex Sealy in Mice.
abstract: Camellia euphlebia Merr. ex Sealy is a traditional Chinese medicine that has been widely used for improvement of human emotions in the Guangxi Province of southern China. However, there are no studies about the anxiolytic and antidepressant activities of Camellia euphlebia. This study evaluated the anxiolytic and antidepressant activities of the aqueous extract from Camellia euphlebia (CEE) in mice. We found that administration of 400 mg/kg CEE or 20 mg/kg fluoxetine for 7 days significantly reduced the immobility time in both TST and FST. Oral administration of 100 mg/kg extract or 4 mg/kg diazepam for 7 days significantly increased the percentage of time spent and the number of entries into the open arms of the EPMT. In addition, the time spent by mice in the illuminated side of the LDBT was increased. Furthermore, pretreatment with 400 mg/kg CEE for 7 days significantly elevated the level of 5-HT and DA in the whole brain of mice. These results provide support for the potential anxiolytic and antidepressant activity of Camellia euphlebia and contribute towards validation of the traditional use of Camellia euphlebia in the treatment of emotional disorders.
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China ; Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China.
authors.forename: Dongye
authors.initials: D
authors.lastname: He
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China.
authors.forename: Xitao
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China ; Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China ; Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China.
authors.forename: Xinxing
authors.initials: X
authors.lastname: Luo
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China ; Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China ; Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.affiliation: Dalian SEM Bio-Engineering Technology Co. Ltd., Dalian 116620, China.
authors.forename: Shuying
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China ; Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian 116620, China ; Dalian SEM Bio-Engineering Technology Co. Ltd., Dalian 116620, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Xu