title: Role of the lysophosphatidylinositol/GPR55 axis in cancer.
abstract: Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for LPI. Several investigations have demonstrated that the signalling pathways activated by LPI through its receptor GPR55 play a pivotal role in different cancer type. This review focuses on the role of the LPI/GPR55 axis, in particular with regards to its pharmacological potential therapeutic exploitation.
authors.affiliation: Metabolic Signalling Group, School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, Western Australia 6102, Australia; Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, 4 Newark Street, London E1 2AT, UK. Electronic address: marco.falasca@curtin.edu.au.
authors.forename: Marco
authors.initials: M
authors.lastname: Falasca
authors.affiliation: Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, 4 Newark Street, London E1 2AT, UK.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ferro
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D043882:Receptors, Cannabinoid; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C524885:GPR55 protein, human; D008246:Lysophospholipids; D043882:Receptors, Cannabinoid; D043562:Receptors, G-Protein-Coupled; C025449:lysophosphatidylinositol
keywords: ABC transporters; Cancer; Cannabidiol; G protein-coupled receptor 55; LPI