title: The Hierarchy of Transcriptional Activation: From Enhancer to Promoter.
abstract: Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.
authors.affiliation: The Roslin Institute, Developmental Biology Division, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK. Electronic address: douglas.vernimmen@roslin.ed.ac.uk.
authors.forename: Douglas
authors.initials: D
authors.lastname: Vernimmen
authors.affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Bickmore
mesh_terms: D004742:Enhancer Elements, Genetic; D011401:Promoter Regions, Genetic; D015533:Transcriptional Activation