title: Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential.
abstract: MicroRNAs (miRNAs) are a recently discovered class of endogenous, small (about 22 nucleotides) non-coding RNAs, which play important roles in cancer development and progression. Emerging evidence shows that microRNAs exert their regulatory effects by directly binding to the 3'- untranslated regions (UTRs) of their target genes. MicroRNA-100 (miR-100) is aberrantly expressed and functions in many human cancers by regulating multiple cell processes, such as cell cycle, proliferation, differentiation, migration, invasion and apoptosis, via post-transcriptionally regulating various target genes. A better understanding of the molecular mechanisms involved in miR-100-mediated tumor progression will provide an opportunity for exploring novel miR-100-based targeted therapies for human cancers. This review aims to summarize the recently published literature on the roles of miR-100 in regulating tumorigenesis, and explore its potential clinical applications for cancer diagnosis, prognosis and clinical treatment.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Yanping
authors.initials: Y
authors.lastname: Gao
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Siqi
authors.initials: S
authors.lastname: Han
authors.forename: Bing
authors.initials: B
authors.lastname: Feng
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Longbang
authors.initials: L
authors.lastname: Chen
mesh_terms: D020413:3' Untranslated Regions; D017209:Apoptosis / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D009361:Neoplasm Invasiveness / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy
chemical_list: D020413:3' Untranslated Regions; C544266:MIRN100 microRNA, human; D035683:MicroRNAs