title: Intracellular transport and cell surface delivery of the neural cell adhesion molecule (NCAM).
abstract: The neural cell adhesion molecule (NCAM) regulates differentiation and functioning of neurons by accumulating at the cell surface where it mediates the interactions of neurons with the extracellular environment. NCAM also induces a number of intracellular signaling cascades, which coordinate interactions at the cell surface with intracellular processes including changes in gene expression, transport and cytoskeleton remodeling. Since NCAM functions at the cell surface, its transport and delivery to the cell surface play a critical role. Here, we review recent advances in our understanding of the molecular mechanisms of the intracellular transport and cell surface delivery of NCAM. We also discuss the data suggesting a possibility of cross talk between activation of NCAM at the cell surface and the intracellular transport and cell surface delivery of NCAM.
authors.affiliation: a School of Biotechnology and Biomolecular Sciences ; The University of New South Wales ; Sydney , NSW , Australia.
authors.forename: Iryna
authors.initials: I
authors.lastname: Leshchyns'ka
authors.affiliation: a School of Biotechnology and Biomolecular Sciences ; The University of New South Wales ; Sydney , NSW , Australia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Sytnyk
mesh_terms: D000818:Animals; D006801:Humans; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology*; D020239:Receptor Cross-Talk / Q000502:physiology*
chemical_list: D019006:Neural Cell Adhesion Molecules
keywords: cell adhesion molecule; exocytosis; kinesin; neurons; p21-activated protein kinase; transport