title: Impact of Anemia and Dual Antiplatelet Therapy on Mortality in Patients Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents.
abstract: The objective was to assess the impact of baseline anemia on all-cause mortality and whether 12-month dual antiplatelet therapy (DAPT) affects 1-year mortality linked to anemia in patients after percutaneous coronary intervention (PCI) with drug-eluting stents (DES). 4109 enrolled patients divided into three groups based on their pre-procedural hemoglobin (Hb) level: Hb < 100 mg/L represented moderate-severe anemia; 100 mg/L ≤ Hb < 120 mg/L for women and 100 mg/L ≤ Hb < 130 mg/L for men represented mild anemia; Hb ≥ 20 mg/L for women and Hb ≥ 130 mg/L for men represented no anemia. DAPT medications were prescribed when patients were discharged. There were significant differences in 30-day and 1-year mortality between moderate-severe anemia and no anemia patients (HR 8.05, 95% CI 1.46 to 44.33, P = 0.017; HR 3.93, 95% CI 1.11 to 13.98, P = 0.034), and in long-term mortality between anemia and no anemia groups (HR 1.82, 95% CI 1.17 to 2.83, P = 0.008 for mild anemia; HR 3.19,95% CI 1.29 to 7.86, P = 0.012 for moderate-severe anemia). There was not significant interaction between 12-month DAPT and anemia on mortality in anemic patients (P for interaction > 0.05). Anemia shows association with increased all-cause mortality in patients undergoing PCI. Twelve-month DAPT does not show synergy with anemia to increase the risk of all-cause 1-year mortality in anemic patients after PCI.
authors.affiliation: School of Public Health, Capital Medical University, Beijing, China.|School of General Practice and Continuing Education, Capital Medical University, Beijing, China.
authors.forename: Huili
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: School of Public Health, Capital Medical University, Beijing, China.
authors.forename: Lufeng
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Beijing University of Chinese Medicine Dongzhimen Hospital, Beijing, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
authors.forename: Jinguo
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan Province, China.
authors.forename: Shouyan
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Public Health, Capital Medical University, Beijing, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Peking University People's Hospital, Beijing, China.
authors.forename: Dayi
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Cardiology, Peking University People's Hospital, Beijing, China.
authors.forename: Rongjing
authors.initials: R
authors.lastname: Ding
mesh_terms: D000368:Aged; D000740:Anemia / Q000209:etiology / Q000473:pathology*; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000209:etiology
chemical_list: D006454:Hemoglobins; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin