title: A new nano-worm structure from gold-nanoparticle mediated random curving of zinc oxide nanorods.
abstract: Creating novel nanostructures is a primary step for high-performance analytical sensing. Herein, a new worm like nanostructure with Zinc Oxide-gold (ZnO/Au) hybrid was fabricated through an aqueous hydrothermal method, by doping Au-nanoparticle (AuNP) on the growing ZnO lattice. During ZnO growth, fine tuning the solution temperature expedites random curving of ZnO nanorods and forms nano-worms. The nano-worms which were evidenced by morphological, physical and structural analyses, revealed elongated structures protruding from the surface (length: 1 µm; diameter: ~100 nm). The appropriate peaks for the face centred cubic gold were (111) and (200), as seen from X-ray diffractogram. The strong interrelation between Au and ZnO was manifested by X-ray photoelectron spectroscopy. The combined surface area increment from the nanoparticle radii and ZnO nanorod random curving gives raise an enhancement in detection sensitivity by increasing bio-loading. 'Au-decorated hybrid nano-worm' was immobilized with a probe DNA from Vibrio Cholera and duplexed with a target which was revealed by Fourier Transform Infrared Spectroscopy. Our novel Au-decorated hybrid nano-worm is suitable for high-performance bio-sensing, as evidenced by impedance spectroscopy, having higher-specificity and attained femtomolar (10 fM) sensitivity. Further, higher stability, reproducibility and regeneration on this sensing surface were demonstrated.
authors.affiliation: Biomedical Nano Diagnostics Research Group, Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP), Kangar, Perlis, Malaysia.
authors.forename: Veeradasan
authors.initials: V
authors.lastname: Perumal
authors.affiliation: Biomedical Nano Diagnostics Research Group, Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP), Kangar, Perlis, Malaysia; School of Microelectronic Engineering, University Malaysia Perlis (UniMAP), Kuala Perlis, Perlis, Malaysia. Electronic address: uda@unimap.edu.my.
authors.forename: Uda
authors.initials: U
authors.lastname: Hashim
authors.affiliation: Biomedical Nano Diagnostics Research Group, Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP), Kangar, Perlis, Malaysia.
authors.forename: Subash C B
authors.initials: SCB
authors.lastname: Gopinath
authors.affiliation: Biomedical Nano Diagnostics Research Group, Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP), Kangar, Perlis, Malaysia.
authors.forename: R
authors.initials: R
authors.lastname: Haarindraprasad
authors.affiliation: School of Microelectronic Engineering, University Malaysia Perlis (UniMAP), Kuala Perlis, Perlis, Malaysia.
authors.forename: P
authors.initials: P
authors.lastname: Poopalan
authors.affiliation: Biomedical Nano Diagnostics Research Group, Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP), Kangar, Perlis, Malaysia.
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Liu
authors.affiliation: Department of Biotechnology, Faculty of Applied Sciences, Asian Institute of Medicine, Science & Technology (AIMST), Semelling, Bedong, Kedah, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Ravichandran
authors.affiliation: Biomedical Nano Diagnostics Research Group, Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP), Kangar, Perlis, Malaysia.
authors.forename: S R
authors.initials: SR
authors.lastname: Balakrishnan
authors.affiliation: Biomedical Nano Diagnostics Research Group, Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP), Kangar, Perlis, Malaysia.
authors.forename: A R
authors.initials: AR
authors.lastname: Ruslinda
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004269:DNA, Bacterial / Q000737:chemistry / Q000302:isolation & purification*; D055664:Electrochemical Techniques / Q000379:methods*; D006046:Gold / Q000737:chemistry; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry; D014734:Vibrio cholerae / Q000302:isolation & purification*; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry
chemical_list: D004269:DNA, Bacterial; D006046:Gold; D015034:Zinc Oxide
keywords: Cholera; DNA; Gold nanoparticle; Nano-worm; Nanorod; Zinc Oxide