title: Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma.
abstract: Primary thyroid lymphoma (PTL) is a rare malignant thyroid tumor; its pathogenesis is closely related to chronic lymphocytic thyroiditis. The different pathological subtypes and stages of PTL have distinct clinical characteristics and prognosis, but the specific reasons are not clear. Wnt5a is a representative protein of non-canonical Wnt signaling. It plays an important role in many different types of tumors. This study is to explore the changes of Wnt5a and its receptor Ror2 in PTL development process and the clinical significance of their represent. We collected 22 PTL patient tumor specimens and clinical data. We observed the expression of Wnt5a and Ror2 in PTL tumor tissues by immunohistochemistry. Wnt5a was expressed positively in 12 (54.5 %) cases, and Ror2 was expressed positively in 18 (81.8 %) cases. The expression of Wnt5a had a significant difference in different pathological subtypes of PTL (P < 0.05). Wnt5a and Ror2 expression were associated with local invasion and clinical stage, respectively (P < 0.05), and had no significant correlation with age, gender, and tumor size. Although, no significant difference in overall survival was found between positive and negative groups of Wnt5a (P = 0.416) or Ror2 (P = 0.256), respectively. We still consider that Wnt5a and Ror2 play a complex and subtle role in the pathogenesis and progression of PTL and may become potential biomarkers and therapeutic targets of PTL.
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of General Surgery, NO.202 Hospital of PLA, Shenyang, China.
authors.forename: Ying-Hou
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Hong-Ming
authors.initials: HM
authors.lastname: Gao
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Jun-Yuan
authors.initials: JY
authors.lastname: Lv
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang, China. sjxin@mail.cmu.edu.cn.
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Xin
mesh_terms: D000328:Adult; D000368:Aged; D045744:Cell Line, Tumor; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008223:Lymphoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D047368:Tumor Burden; D000071818:Wnt-5a Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D000071818:Wnt-5a Protein; C078717:ROR2 protein, human; D057050:Receptor Tyrosine Kinase-like Orphan Receptors
keywords: Immunohistochemistry; Primary thyroid lymphoma; Ror2; Wnt5a