title: mTORC2 is a tyrosine kinase.
abstract: The mammalian target of rapamycin (mTOR), a protein kinase, is the centre of huge attention due to its importance in intracellular signaling and in health and disease. In their recent study, Yin et al. show that mTOR can regulate signaling through the insulin-like growth factor 1 receptor and that it possesses a new enzymatic activity - the ability to phosphorylate proteins on tyrosine residues.
authors.affiliation: Nutrition and Metabolism Theme, South Australian Health & Medical Research Institute, North Terrace, and University of Adelaide, Adelaide, Australia.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Nutrition and Metabolism Theme, South Australian Health & Medical Research Institute, North Terrace, and University of Adelaide, Adelaide, Australia.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Proud
mesh_terms: D000818:Animals; D006801:Humans; D000076225:Mechanistic Target of Rapamycin Complex 2; D046912:Multiprotein Complexes / Q000378:metabolism*; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
chemical_list: D046912:Multiprotein Complexes; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin; D000076225:Mechanistic Target of Rapamycin Complex 2; D058570:TOR Serine-Threonine Kinases