title: [Anti-RANKL antibody for the treatment of bone and cartilage destruction in rheumatoid arthritis].
abstract: Rheumatoid arthritis (RA) is characterized by chronic synovitis and RANKL-dependent osteoclastogenesis leading to bone damage, which causes severe physical disability. Focal and systemic bone and cartilage destruction including secondary osteoporosis contributes to the morbidity associated with RA. The biologics targeting TNF and IL-6 has revolutionized the treatment of RA, producing significant improvements in clinical and structural outcomes. Furthermore, an anti-RANKL antibody denosumab possesses a potential to inhibit joint destruction as well as systemic osteoporosis. Targeting RANKL therapy will most likely enlarge the possibilities of osteoporosis treatment and improve the prognosis in RA patients.
authors.affiliation: The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Nakayamada
authors.affiliation: The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D001847:Bone Diseases / Q000188:drug therapy / Q000276:immunology*; D002357:Cartilage Diseases / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D010010:Osteoclasts / Q000187:drug effects / Q000276:immunology; D011379:Prognosis; D053245:RANK Ligand / Q000276:immunology*
chemical_list: D000906:Antibodies; D053245:RANK Ligand