title: Tanshinone IIA inhibits acute promyelocytic leukemia cell proliferation and induces their apoptosis in vivo.
abstract: Tanshinone IIA (TanIIA) is a traditional Chinese agent and has been widely used for treatment of cardiovascular diseases. Our previous study has shown that TanIIA can induce the differentiation of acute promyelocytic leukemia (APL) cells by increasing C/EBPβ expression and induce APL cell apoptosis in vitro. In this study, we evaluated the activity of TanIIA against APL in vivo. We found that treatment with TanIIA prevented APL-mediated reduction in body weights. Treatment with TanIIA inhibited the proliferation of APL cells and triggered APL cell apoptosis and differentiation in vivo. Treatment with TanIIA significantly prolonged the survival of APL-bearing mice. Our data indicate that TanIIA has potent anti-APL activity with little adverse effect.
authors.affiliation: Department of Hematology, Guizhou Medical University Affiliated Hospital, Guiyang 550004, Guizhou Province, China.
authors.forename: Kaiji
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Hematology, West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Wentong
authors.initials: W
authors.lastname: Meng
authors.affiliation: Department of Hematology, Sichuan Medical University affiliated hospital, Luzhou 646000, Sichuan Province, China.
authors.forename: Hongyun
authors.initials: H
authors.lastname: Xing
authors.affiliation: Department of Hematology, West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China. Electronic address: laurayang1944@hotmail.com.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Yang
mesh_terms: D045784:Abietanes / Q000627:therapeutic use*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000473:pathology; D016513:Mice, SCID
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; C021751:tanshinone
keywords: Acute promyelocytic leukemia; Apoptosis; Mice; Proliferation; Tanshinone IIA