title: Environmental stress stability of microencapsules based on liposomes decorated with chitosan and sodium alginate.
abstract: In this study, liposomes (LPs), chitosan (CH) coated LPs, sodium alginate (AL) and CH multilayered LPs (AL-CH-LPs) were developed based on the electrostatic interaction between charged polysaccharides at a certain pH. The increase of polymer layers on LPs led to a monotonic increase in size from ∼600 (LPs) to ∼1810 nm (AL-CH-LPs) and negative charge from -12.5 to -25.2 mV, regarded as a consequence of the formation of gradually expanded structures by cationic CH and anionic AL. The environmental stress including pH, storage and ionic strength (10-200 mM NaCl) had significant impact on the appearance and the particle size of the double-layered liposome (AL-CH-LPs). Furthermore, LPs showed the highest release rate of hydrophilic model ingredient (vitamin C) under gastrointestinal conditions, while the polymers had a capacity to reduce the vitamin C release in simulated intestinal fluid. This work provided useful information on the potential application of CH and AL based delivery systems.
authors.affiliation: College of Food and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, Zhejiang, PR China.
authors.forename: Weilin
authors.initials: W
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China. Electronic address: liuwei@ncu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Riddet Institute, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand.
authors.forename: Aiqian
authors.initials: A
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China.
authors.forename: Shengfeng
authors.initials: S
authors.lastname: Peng
authors.affiliation: College of Food and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, Zhejiang, PR China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China.
authors.forename: Chengmei
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Food and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, Zhejiang, PR China. Electronic address: hanjz99@zjgsu.edu.cn.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Han
mesh_terms: D000464:Alginates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D004356:Drug Storage; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry*; D009994:Osmolar Concentration; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D055672:Static Electricity
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D008081:Liposomes; D011108:Polymers; D020723:Glucuronic Acid; D048271:Chitosan
keywords: Alginate; Chitosan; Environmental stress; Liposome; Microencapsule; Structure stability