title: Midterm Outcomes Following Total Knee Arthroplasty in Lupus Patients.
abstract: BACKGROUND
  An increasing number of patients with systemic lupus erythematosus (SLE) are undergoing total knee arthroplasty (TKA), but there are few studies detailing their outcomes. The purpose of this study was to evaluate TKA cohort of patients who had SLE compared with a matched cohort who did not have this disease by analyzing (1) implant survivorship, (2) functional outcomes, (3) complication rates, (4) health-related quality of life, and (5) patient-perceived activity level.
  
  
  METHODS
  A retrospective review of all patients who underwent TKA and had an International Classification of Diseases, Ninth Revision, code diagnosis for SLE was performed at 3 high-volume institutions. A total of 31 patients (34 arthroplasties) were identified, and they were compared with a matched cohort (1:3) who did not have SLE and had undergone a primary TKA during this same time period.
  
  
  RESULTS
  After a mean 6-year follow-up (range, 2-10 years), both cohorts had similar implant survivorship (91% vs 99%). In addition, each cohort had similar complication rates (odds ratio = 1.9, 0.99-13). Functional outcomes were similar as measured by Knee Society Scores objective (90 vs 91 points) and functional (89 vs 90 points). There were no differences in Short Form-36 physical (47 vs 49 points) or mental components (51 vs 53 points). University of California Los Angeles activity scores were similar as well (5.1 vs 5.9 points).
  
  
  CONCLUSIONS
  Our study demonstrated comparable excellent clinical and patient-reported outcomes of TKA in patients with or without SLE. Prospective studies are necessary to evaluate these outcomes at longer follow-up.
authors.affiliation: Seton Hall University, School of Health and Medical Sciences, Department of Orthopaedics, South Orange, New Jersey.
authors.forename: Kimona
authors.initials: K
authors.lastname: Issa
authors.affiliation: Seton Hall University, School of Health and Medical Sciences, Department of Orthopaedics, South Orange, New Jersey.
authors.forename: Todd P
authors.initials: TP
authors.lastname: Pierce
authors.affiliation: Seton Hall University, School of Health and Medical Sciences, Department of Orthopaedics, South Orange, New Jersey.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Scillia
authors.affiliation: Seton Hall University, School of Health and Medical Sciences, Department of Orthopaedics, South Orange, New Jersey.
authors.forename: Anthony
authors.initials: A
authors.lastname: Festa
authors.affiliation: Mount Sinai Beth Israel Hospital, New York, New York.
authors.forename: Steven F
authors.initials: SF
authors.lastname: Harwin
authors.affiliation: Center for Joint Preservation and Replacement, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Mont
mesh_terms: D000328:Adult; D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000150:complications / Q000601:surgery*; D007719:Knee Joint / Q000601:surgery*; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011475:Prosthesis Failure; D011788:Quality of Life; D020127:Recovery of Function; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: complications; outcomes; survivorship; systemic lupus erythematosus; total knee arthroplasty