title: RNA editing by ADAR1 marks dsRNA as "self".
abstract: A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.
authors.affiliation: National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yu
authors.affiliation: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, China.
authors.forename: Taoyong
authors.initials: T
authors.lastname: Chen
authors.affiliation: National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.|National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, China.
authors.forename: Xuetao
authors.initials: X
authors.lastname: Cao
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D020964:Embryo Loss / Q000235:genetics*; D017393:RNA Editing; D012330:RNA, Double-Stranded / Q000378:metabolism*
chemical_list: D012330:RNA, Double-Stranded; D000243:Adenosine Deaminase; D053487:DEAD-box RNA Helicases