title: Longitudinal DRG-based survey of all-cause and pneumococcal pneumonia and meningitis for inpatients in France (2005-2010).
abstract: OBJECTIVE
  This population-based retrospective study quantified the burden of all-cause and pneumococcal pneumonia and meningitis in the Rhône-Alpes region of France from 2005 to 2010, when the 7-valent pneumococcal conjugate vaccine uptake increased from 50 to>90% in children.
  
  
  METHODS
  Hospital admission data was obtained from the French Diagnosis Related Groups program database (French acronym PMSI). Patients were residents of the Rhône-Alpes region hospitalized for the diseases of interest during 2005-2010. Hospitalization and in-hospital mortality rates were calculated by age, sex, and year on the basis of the Rhône-Alpes region population. Hospitalization and in-hospital mortality rates were compared using Chi(2) tests with statistical significance adjusted for multiple comparisons.
  
  
  RESULTS
  The highest hospitalization rates by age group were: all-cause pneumonia, oldest group (>65 years); all-cause and pneumococcal meningitis, youngest group (0-4 years), and pneumococcal pneumonia, youngest and oldest groups. Hospitalization rates significantly decreased for all-cause pneumonia (5-19 years: -12.71%) and all-cause meningitis (20-49 years: -29.22%). Pneumococcal disease rates did not significantly change in any age group. Mortality rates from all-cause pneumonia and meningitis were highest in the oldest age groups.
  
  
  CONCLUSIONS
  The burden of all-cause and pneumococcal pneumonia and meningitis remains substantial. Significant changes (decreases) between 2005 and 2010 in hospitalization rates were limited and varied among age groups, most likely because this study began 2 years after PCV7 was first introduced in France for children at broadly-defined high risk. Further research is needed on the relationship between serotype epidemiology and clinical patterns of disease.
authors.affiliation: Service d'information et d'évaluation médicale, centre hospitalier Annecy-Genevois, 1, avenue de l'Hôpital, 74370 Pringy, France. Electronic address: pcasez@ch-annecygenevois.fr.
authors.forename: P
authors.initials: P
authors.lastname: Casez
authors.affiliation: TIMC-IMAG, université Joseph-Fourier, CHU de Grenoble, 38041 Saint-Martin-d'Hères, France.
authors.forename: J
authors.initials: J
authors.lastname: Fauconnier
authors.affiliation: Via Research, LLC, Princeton Junction, NJ, 08550, USA.
authors.forename: L
authors.initials: L
authors.lastname: Jorgensen
authors.affiliation: Via Research, LLC, Princeton Junction, NJ, 08550, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Gutterman
authors.affiliation: Pfizer Inc, Collegeville, PA, 19426, USA.
authors.forename: S
authors.initials: S
authors.lastname: Gray
authors.affiliation: Pfizer Inc, Collegeville, PA, 19426, USA.
authors.forename: S
authors.initials: S
authors.lastname: Munson
authors.affiliation: Pfizer Europe, 75668 Paris cedex 14, France.
authors.forename: N
authors.initials: N
authors.lastname: Dartois
authors.affiliation: Service d'information et d'évaluation médicale, centre hospitalier Annecy-Genevois, 1, avenue de l'Hôpital, 74370 Pringy, France.
authors.forename: J
authors.initials: J
authors.lastname: Gaillat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003953:Diagnosis-Related Groups; D005260:Female; D005602:France / Q000453:epidemiology; D006306:Health Surveys; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology* / Q000517:prevention & control; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000453:epidemiology / Q000517:prevention & control; D011018:Pneumonia, Pneumococcal / Q000453:epidemiology* / Q000517:prevention & control; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine
keywords: Incidence; Infections à pneumocoque; Meningitis; Méningite; Pneumococcal infections; Pneumonia; Pneumopathie