title: Biological Behaviour and Enhanced Anticorrosive Performance of the Nitrided Superelastic Ti-23Nb-0.7Ta-2Zr-0.5N Alloy.
abstract: The influence of gas nitriding surface treatment on the superelastic Ti-23Nb-0.7Ta-2Zr-0.5N alloy was evaluated. A thorough characterization of bare and nitrided Ti-based alloy and pure Ti was performed in terms of surface film composition and morphology, electrochemical behaviour, and short term osteoblast response. XPS analysis showed that the nitriding treatment strongly influenced the composition (nitrides and oxynitrides) and surface properties both of the substrate and of the bulk alloy. SEM images revealed that the nitrided surface appears as a similar dotted pattern caused by the formation of N-rich domains coexisting with less nitrided domains, while before treatment only topographical features could be observed. All the electrochemical results confirmed the high chemical stability of the nitride and oxynitride coating and the superiority of the applied treatment. The values of the corrosion parameters ascertained the excellent corrosion resistance of the coated alloy in the real functional conditions from the human body. Cell culture experiments with MG63 osteoblasts demonstrated that the studied biomaterials do not elicit any toxic effects and support cell adhesion and enhanced cell proliferation. Altogether, these data indicate that the nitrided Ti-23Nb-0.7Ta-2Zr-0.5N alloy is the most suitable substrate for application in bone implantology.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.
authors.forename: Valentina
authors.initials: V
authors.lastname: Mitran
authors.affiliation: Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Splaiul Independentei 202, 060021 Bucharest, Romania.
authors.forename: Cora
authors.initials: C
authors.lastname: Vasilescu
authors.affiliation: Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Splaiul Independentei 202, 060021 Bucharest, Romania.
authors.forename: Silviu Iulian
authors.initials: SI
authors.lastname: Drob
authors.affiliation: Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Splaiul Independentei 202, 060021 Bucharest, Romania.
authors.forename: Petre
authors.initials: P
authors.lastname: Osiceanu
authors.affiliation: Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Splaiul Independentei 202, 060021 Bucharest, Romania.
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Calderon-Moreno
authors.affiliation: INSA Rennes, UMR CNRS 6226 Institut des Sciences Chimiques de Rennes, 20 avenue de Buttes de Coëmes, 35708 Rennes Cedex 07, France.
authors.forename: Mariana-Cristina
authors.initials: MC
authors.lastname: Tabirca
authors.affiliation: INSA Rennes, UMR CNRS 6226 Institut des Sciences Chimiques de Rennes, 20 avenue de Buttes de Coëmes, 35708 Rennes Cedex 07, France.
authors.forename: Doina-Margareta
authors.initials: DM
authors.lastname: Gordin
authors.affiliation: INSA Rennes, UMR CNRS 6226 Institut des Sciences Chimiques de Rennes, 20 avenue de Buttes de Coëmes, 35708 Rennes Cedex 07, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Gloriant
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.
authors.forename: Anisoara
authors.initials: A
authors.lastname: Cimpean
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000627:therapeutic use*; D001672:Biocompatible Materials; D000069343:Bone-Implant Interface; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000187:drug effects*; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D014025:Titanium