title: [THE INFLUENCE OF NEW DIRECT ANTICOAGULANT THIAZOLINE AMMONIUM 4-CHLOROPHENYL-2-HYDROXY-4-OXO-2-BUTENOATE ON BLOOD COAGULATION INDICES].
abstract: The influence of newly synthesized compound--thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate (FS-169), which has a direct anticoagulant--on the indices of coagulation activity has been studied in rabbit blood plasma with the aid of an APG4-02-P coagulometer. It is established that FS-169 reliably extends the partial thromboplastin time by 122.2% (p < 0.001) and the prothrombin time by 49.1% (p = 0.001), increases the prothrombin index by 30.9% (p = 0.001), and decreases the prothrombin ratio and international normalized ratio by 40.0% (p = 0.001). At the same time FS-169 does not influence the thrombin time FS-169.
authors.forename: A V
authors.initials: AV
authors.lastname: Starkov
authors.forename: B Ya
authors.initials: BY
authors.lastname: Syropyatov
authors.forename: F V
authors.initials: FV
authors.lastname: Sobin
authors.forename: N A
authors.initials: NA
authors.lastname: Pullina
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D011517:Prothrombin Time; D011817:Rabbits; D014753:Vinyl Compounds / Q000494:pharmacology*
chemical_list: C586859:4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate; D000085:Acetates; D000925:Anticoagulants; D001555:Benzene Derivatives; D014753:Vinyl Compounds