title: [Treatment of Tritrichomonas foetus in a cat colony with delayed release ronidazole tablets in the small intestine].
abstract: Seven abyssinian cats (two male, five female) showed intermittent green-yellow mucous diarrhoea, sometimes an inflammation of the anal region and faecal incontinence even after long-time treatment with fenbendazole against Giardia. During necropsy of one of the cats, which had to be euthanized due to another disease, the gut wall of small and large intestine appeared macroscopically thickened. Histological examination indicated flagellates in the lumen of the intestine (initiating at the jejunum) and in the crypts. However Giardia could be excluded. in this case. By PCR of the faeces Tritrichomonas (T) foetus was diagnosed in five of six cats of this colony. Five remaining animals (another cat had to be euthanized) were treated with about 30 mg per kg BW ronidazole p. o. (rededication; Ridzol 10% Bt®, Dr. Hesse Tierpharma GmbH & Co. KG, Germany) daily over 14 days. The special gastro-resistant processing of the ronidazole should ensure a targeted effects. Animals were treated consecutively, isolated from the other cats and were daily examined clinically and neurologically. Neurotoxic adverse effects appeared slightly, therefore--as a precaution--the treatment of two cats was paused for one day. After treatment of all cats, T. foetus wasn't diagnosed by PCR over the period of 345 to > 800 days in any cat. One animal had dubious findings in the ninth week after treatment. Hence it was still kept isolated from the group and PCR showed a negative result at all times afterwards. The treatment protocol shows that elimination of problematic protozoal infections is possible in cat colonies.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Reinert
authors.forename: Susanne
authors.initials: S
authors.lastname: Gerold
authors.forename: Ulf
authors.initials: U
authors.lastname: Scheurlen
authors.forename: Rolf
authors.initials: R
authors.lastname: Daniels
authors.forename: Matthias
authors.initials: M
authors.lastname: Wolm
authors.forename: Franz
authors.initials: F
authors.lastname: Iglauer
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002371:Cat Diseases / Q000188:drug therapy* / Q000378:metabolism; D002415:Cats; D003692:Delayed-Action Preparations; D005260:Female; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D011529:Protozoan Infections, Animal / Q000188:drug therapy* / Q000378:metabolism; D012385:Ronidazole / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013607:Tablets; D016835:Tritrichomonas foetus
chemical_list: D000981:Antiprotozoal Agents; D003692:Delayed-Action Preparations; D013607:Tablets; D012385:Ronidazole