title: Assessment of Clostridium difficile Burden in Patients Over Time With First Episode Infection Following Fidaxomicin or Vancomycin.
abstract: In patients with first episode Clostridium difficile infection treated with vancomycin or fidaxomicin, more patients receiving fidaxomicin achieved at least 2 log10 colony-forming units/g reduction in spores at the follow-up visit (P=.02). Similar to published literature, a higher proportion of patients receiving fidaxomicin demonstrated sustained clinical response.
authors.affiliation: 1Center for Anti-Infective Research and Development,Hartford Hospital,Hartford,Connecticut.
authors.forename: Seth T
authors.initials: ST
authors.lastname: Housman
authors.affiliation: 1Center for Anti-Infective Research and Development,Hartford Hospital,Hartford,Connecticut.
authors.forename: Abrar K
authors.initials: AK
authors.lastname: Thabit
authors.affiliation: 1Center for Anti-Infective Research and Development,Hartford Hospital,Hartford,Connecticut.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Kuti
authors.affiliation: 2Division of Infectious Diseases,Hartford Hospital,Hartford,Connecticut.
authors.forename: Richard
authors.initials: R
authors.lastname: Quintiliani
authors.affiliation: 1Center for Anti-Infective Research and Development,Hartford Hospital,Hartford,Connecticut.
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
mesh_terms: D000328:Adult; D000368:Aged; D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D015169:Colony Count, Microbial; D003237:Connecticut; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy*; D005243:Feces / Q000382:microbiology; D005260:Female; D000077732:Fidaxomicin; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D014640:Vancomycin; D000077732:Fidaxomicin