title: Regulation of lamin properties and functions: does phosphorylation do it all?
abstract: The main functions of lamins are their mechanical and structural roles as major building blocks of the karyoskeleton. They are also involved in chromatin structure regulation, gene expression, intracellular signalling pathway modulation and development. All essential lamin functions seem to depend on their capacity for assembly or disassembly after the receipt of specific signals, and after specific, selective and precisely regulated interactions through their various domains. Reversible phosphorylation of lamins is crucial for their functions, so it is important to understand how lamin polymerization and interactions are modulated, and which sequences may undergo such modifications. This review combines experimental data with results of our in silico analyses focused on lamin phosphorylation in model organisms to show the presence of evolutionarily conserved sequences and to indicate specific in vivo phosphorylations that affect particular functions.
authors.affiliation: Laboratory of Nuclear Proteins, Faculty of Biotechnology, University of Wrocław, ul. Fryderyka Joliot-Curie 14a, Wrocław 50-383, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Machowska
authors.affiliation: Laboratory of Nuclear Proteins, Faculty of Biotechnology, University of Wrocław, ul. Fryderyka Joliot-Curie 14a, Wrocław 50-383, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Piekarowicz
authors.affiliation: Laboratory of Nuclear Proteins, Faculty of Biotechnology, University of Wrocław, ul. Fryderyka Joliot-Curie 14a, Wrocław 50-383, Poland rzepecki@ibmb.uni.wroc.pl.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Rzepecki
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D034882:Lamins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational
chemical_list: D034882:Lamins
keywords: Cdk1/PKA/PKC; chromatin binding; kinase motif; lamin polymerization; nuclear envelope; signalling