title: [Progress in the molecular genetic mechanism of gonadoblastoma].
abstract: Gonadoblastoma (GB), a rare in situ germ cell tumor derived from sex cord and germ cells, is closely associated with gonadal dysgenesis. About 80% of GB individuals exhibit 46, XY female phenotype while the others are 45, XY and 46, XX with disorders of sex development. Moreover, 35% of GB can eventually develop into malignant tumors, such as seminoma and dysgerminoma tumors. The molecular genetic mechanism of GB remains to be fully uncovered due to phenotypic and genetic heterogeneity. Increasing studies show that the formation of GB is closely related to genes regulating sexual differentiation and determination (e.g., SRY, WT1, SOX9, Foxl2, TSPY, etc), and is affected by the interaction of genetic and epigenetic regulation. Here we describe the clinical and pathological features, diagnosis and treatment of GB, and also summarize the molecular genetic and epigenetic mechanisms underlying the gonadal abnormalities that lead to GB. We analyze and construct the common gene regulatory networks related to the development of GB, and describe some obstacles and deficiencies in current studies to provide innovative perspectives on further studying the pathological and molecular mechanisms of GB.
authors.affiliation: Department of Medical Genetics and Pharmacogenomics, Faculty of Medicine, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Li-li
authors.initials: LL
authors.lastname: Yu
authors.affiliation: 1. Department of Medical Genetics and Pharmacogenomics, Faculty of Medicine, Kunming University of Science and Technology, Kunming 650500, China; 2. College of Life Science and Technology ,Faculty of Medicine, Kunming University of Science and Technology, Kunming 650500, China;
authors.forename: Wan-ru
authors.initials: WR
authors.lastname: Dong
authors.affiliation: Department of Medical Genetics and Pharmacogenomics, Faculty of Medicine, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Ming-hui
authors.initials: MH
authors.lastname: Chen
authors.affiliation: Department of Medical Genetics and Pharmacogenomics, Faculty of Medicine, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Xiang-yang
authors.initials: XY
authors.lastname: Kong
mesh_terms: D044127:Epigenesis, Genetic; D005260:Female; D053263:Gene Regulatory Networks; D016162:Genes, Wilms Tumor; D018238:Gonadoblastoma / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D051876:Sex-Determining Region Y Protein / Q000235:genetics
chemical_list: C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein