title: Hypoxic Episodes in Bronchopulmonary Dysplasia.
abstract: Hypoxic episodes are troublesome components of bronchopulmonary dysplasia (BPD) in preterm infants. Immature respiratory control seems to be the major contributor, superimposed on abnormal respiratory function. Relatively short respiratory pauses may precipitate desaturation and bradycardia. This population is predisposed to pulmonary hypertension; it is likely that pulmonary vasoconstriction also plays a role. The natural history has been well-characterized in the preterm population at risk for BPD; however, the consequences are less clear. Proposed associations of intermittent hypoxia include retinopathy of prematurity, sleep disordered breathing, and neurodevelopmental delay. Future study should address whether these associations are causal relationships.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Suite RBC 3100, Cleveland, OH 44106-6010, USA. Electronic address: rxm6@case.edu.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Martin
authors.affiliation: Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, 11100 Euclid Avenue, Suite RBC 3100, Cleveland, OH 44106-6010, USA.
authors.forename: Juliann M
authors.initials: JM
authors.lastname: Di Fiore
authors.affiliation: Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Suite RBC 3100, Cleveland, OH 44106-6010, USA.
authors.forename: Michele C
authors.initials: MC
authors.lastname: Walsh
mesh_terms: D001049:Apnea / Q000378:metabolism / Q000503:physiopathology*; D001919:Bradycardia / Q000378:metabolism / Q000503:physiopathology; D001997:Bronchopulmonary Dysplasia / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism / Q000503:physiopathology*; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D007231:Infant, Newborn; D007234:Infant, Premature; D012120:Respiration Disorders / Q000378:metabolism / Q000503:physiopathology
keywords: Apnea of prematurity; Desaturation episodes in preterm infants; Neonatal respiratory control