title: Promising biological therapies for ulcerative colitis: A review of the literature.
abstract: Ulcerative colitis (UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. There is no single known unifying cause, and the pathogenesis is multifactorial, with genetics, environmental factors, microbiota, and the immune system all playing roles. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants (including purine antimetabolites, cyclosporine, and tacrolimus), and surgery. Therapeutic goals for UC are evolving. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab, an anti-tumor necrosis factor (TNF)-α monoclonal antibody, is the first biological agent for the treatment of UC. Over the last decade, infliximab and adalimumab (anti-TNF-α agents) have been used for moderate to severe UC, and have been shown to be effective in inducing and maintaining remission. Recent studies have indicated that golimumab (another anti-TNF-α agent), tofacitinib (a Janus kinase inhibitor), and vedolizumab and etrolizumab (integrin antagonists), achieved good clinical remission and response rates in UC. Recently, golimumab and vedolizumab have been approved for UC by the United States Food and Drug Administration. Vedolizumab may be used as a first-line alternative to anti-TNF-α therapy in patients with an inadequate response to corticosteroids and/or immunosuppressants. Here, we provide updated information on various biological agents in the treatment of UC.
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Hirotada
authors.initials: H
authors.lastname: Akiho
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Yokoyama
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nakazono
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Murakami
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Otsuka
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Fukawa
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Esaki
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Niina
authors.affiliation: Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka 802-0077, Japan.
authors.forename: Haruei
authors.initials: H
authors.lastname: Ogino
keywords: Anti-integrin agents; Anti-tumor necrosis factor α agents; Biological therapy; Janus kinase inhibitor; Ulcerative colitis