title: ReSure Sealant for Pars Plana Vitrectomy Wound Closure.
abstract: OBJECTIVE
  ReSure Sealant (Ocular Therapeutix, Bedford, MA) is an ocular sealant that demonstrated both safety and effectiveness in a prospective, randomized clinical trial for sealing clear corneal incisions following cataract surgery and intraocular lens placement in adults.1 PATIENTS AND METHODS: This is the first literature report of ReSure Sealant used for the closure of 23-gauge (G) pars plana vitrectomy (PPV) sclerotomies. A 70-year-old pseudophakic female with a history of epiretinal membrane and branch retinal vein occlusion of the right eye underwent 23-G PPV, membrane peel, and air-fluid exchange and was found to have leaking subconjunctival air at the end of the case. A linear conjunctival incision was performed to access the sclerotomy site. The incisions were then carefully dried before the sealant was applied to seal both the sclera and conjunctiva.
  
  
  RESULTS
  After polymerization, the sealant formed a polyethylene glycol (PEG) hydrogel that was 89% water and 9.44% PEG. PEG is a synthetic material that is non-toxic and inert and, thus, suitable for use in medical products.
  
  
  CONCLUSIONS
  ReSure Sealant may be a safe, quick method to close sclerotomy wounds in select cases. [
authors.forename: Vincent Y
authors.initials: VY
authors.lastname: Ho
authors.forename: Gaurav K
authors.initials: GK
authors.lastname: Shah
authors.forename: Enchun M
authors.initials: EM
authors.lastname: Liu
mesh_terms: D000368:Aged; D003228:Conjunctiva / Q000187:drug effects*; D058450:Endotamponade; D019773:Epiretinal Membrane / Q000601:surgery; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000627:therapeutic use*; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000601:surgery; D012590:Sclera / Q000187:drug effects*; D012599:Sclerostomy; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014821:Vitrectomy; D058106:Wound Closure Techniques
chemical_list: D014014:Tissue Adhesives; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate