title: Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis.
abstract: The objective of the study is to assess the association between rs1801278 and rs2943641 of insulin receptor substrate 1 gene (IRS1) and the susceptibility to type 2 diabetes. A literature search strategy was conducted to identify all references lists of relevant studies. The fixed or random effect model was used to calculate the pooled ORs on the basis of heterogeneity. Further analyses were performed to explore the sources of heterogeneity by sensitivity analysis, meta-regression analysis, and subgroup analysis. There was significant association between rs1801278 and type 2 diabetes risk in recessive model (AA vs. GA + GG, p = 0.043) and codominant model (AA vs. GG, p = 0.007). Subgroup analysis showed that the association between rs1801278 and type 2 diabetes risk was significant in dominant model (GA + AA vs. GG, p = 0.044), codominant model (GA vs. GG, p = 0.039), codominant model (AA vs. GG, p = 0.044), overdominant model (GG + AA vs. GA, p = 0.037) in Asian and codominant model (AA vs. GG, p = 0.039) in Caucasian of rs1801278. The association between rs2943641 and type 2 diabetes risk was significant in codominant model (CT vs. CC, p = 0.023) in Caucasian. This meta-analysis suggests that rs1801278 may play a role in type 2 diabetes risk, especially in Asian. It also indicates that rs2943641 may be associated with type 2 diabetes risk in Caucasian. Further larger studies should be performed to warrant confirmation.
authors.affiliation: Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, People's Republic of China.
authors.forename: Qiuyan
authors.initials: Q
authors.lastname: Li
authors.affiliation: Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, People's Republic of China.
authors.forename: Yuandong
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, People's Republic of China.
authors.forename: Chuntao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, People's Republic of China.
authors.forename: Guangfa
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, People's Republic of China.
authors.forename: Xuelong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, People's Republic of China. xuld@ems.hrbmu.edu.cn.
authors.forename: Lidan
authors.initials: L
authors.lastname: Xu
mesh_terms: D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D044383:Black People / Q000235:genetics / Q000706:statistics & numerical data; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D055106:Genome-Wide Association Study / Q000706:statistics & numerical data; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data
chemical_list: C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins
keywords: IRS1; Meta-analysis; Polymorphism; Susceptibility; Type 2 diabetes