title: Effect of soothing-liver and nourishing-heart acupuncture on early selective serotonin reuptake inhibitor treatment onset for depressive disorder and related indicators of neuroimmunology: a randomized controlled clinical trial.
abstract: OBJECTIVE
  To observe the effect of soothing-liver and nourishing-heart acupuncture on selective serotonin reuptake inhibitor (SSRIs) treatment effect onset in patients with depressive disorder and related indicators of neuroimmunology.
  
  
  METHODS
  Overall, 126 patients with depressive disorder were randomly divided into a medicine and acupuncture-medicine group using a random number table. Patients were treated for 6 consecutive weeks. The two groups were evaluated by the Montgomery-Asberg Depression Rating Scale (MADRS) and Side Effects Rating Scale (SERS) to assess the effect of the soothing-liver and nourishing-heart acupuncture method on early onset of SSRI treatment effect. Changes in serum 5-hydroxytryptamine (5-HT) and inflammatory cytokines before and after treatment were recorded and compared between the medicine group and the acupuncture-medicine group.
  
  
  RESULTS
  The acupuncture-medicine group had significantly lower MADRS scores at weeks 1, 2, 4, and 6 after treatment compared with the medicine group (P < 0.01). The acupuncture group had significantly lower SERS scores at weeks 1, 2, 4, and 6 after treatment compared with the medicine group (P < 0.01). At 6 weeks after treatment, serum 5-HT in the acupuncture-medicine group was significantly higher compared with the medicine group (P < 0.01). Interleukin-6 (IL-6) in the acupuncture-medicine group was significantly lower than that in the medicine group (P < 0.01), whereas there was no significant difference in IL-1β between the groups (P > 0.05). Anti-inflammatory cytokines IL-4 and IL-10 were significantly higher in the acupuncture-medicine group compared with the medicine group (P < 0.01, P < 0.05, respectively).
  
  
  CONCLUSIONS
  The soothing-liver and nourishing-heart acupuncture method can effectively accelerate the onset of SSRI effects when treating depressive disorder and can significantly reduce the adverse reactions of SSRIs. Moreover, acupuncture can enhance serum 5-HT and regulate the balance of pro-inflammatory cytokines and anti-inflammatory cytokines.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Feng
authors.forename: Yali
authors.initials: Y
authors.lastname: Mo
authors.forename: Jingfang
authors.initials: J
authors.lastname: Gao
authors.forename: Hongjing
authors.initials: H
authors.lastname: Mao
authors.forename: Mingfen
authors.initials: M
authors.lastname: Song
authors.forename: Shengdong
authors.initials: S
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Yin
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Liu
mesh_terms: D015670:Acupuncture Therapy; D000293:Adolescent; D000328:Adult; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008099:Liver / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D055815:Young Adult
chemical_list: D016753:Interleukin-10; D015847:Interleukin-4; D015850:Interleukin-6; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; C508609:IL10 protein, human; C508600:IL6 protein, human