title: Olodaterol and vilanterol detection in sport drug testing.
abstract: The possibility of the detection of olodaterol and vilanterol, two novel β2 -agonists, in human urine for the purpose of sport drug testing was investigated. Compounds of interest were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) employing methods commonly used in the World Anti-Doping Agency (WADA) accredited laboratories. For both substances, the respective parent compound was found to be a suitable target analyte for monitoring therapeutic dose administration.
authors.affiliation: Institute of Doping Analysis and Sport Biochemistry Dresden, Dresdner Str. 12, 01731, Kreischa, Germany.
authors.forename: Zdenek
authors.identifier: http://orcid.org/0000-0001-7453-3377
authors.initials: Z
authors.lastname: Chundela
authors.affiliation: Institute of Doping Analysis and Sport Biochemistry Dresden, Dresdner Str. 12, 01731, Kreischa, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Große
mesh_terms: D000280:Administration, Inhalation; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage / Q000652:urine*; D048588:Benzoxazines / Q000008:administration & dosage / Q000652:urine*; D001592:Benzyl Alcohols / Q000008:administration & dosage / Q000652:urine*; D002722:Chlorobenzenes / Q000008:administration & dosage / Q000652:urine*; D002853:Chromatography, Liquid; D004300:Doping in Sports; D006801:Humans; D008297:Male; D008875:Middle Aged; D058573:Performance-Enhancing Substances / Q000008:administration & dosage / Q000652:urine*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D015813:Substance Abuse Detection / Q000379:methods*; D053719:Tandem Mass Spectrometry; D016482:Urinalysis
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D048588:Benzoxazines; D001592:Benzyl Alcohols; D002722:Chlorobenzenes; D058573:Performance-Enhancing Substances; C550468:vilanterol; C549647:olodaterol
keywords: olodaterol; sport drug testing; vilanterol; ß2-agonists