title: [THE INHIBITORY EFFECT OF GLYCINE AND GABA ON MONOSYNAPTIC EPSPs IN THE FROG SPTNAL MOTONFUCTYNMR].
abstract: In this research we have studied the inhibitory effect of glycine and GABA on the monosynaptic EPSPs induced by microstimulation of presynaptic fibers close to the frog lumbar motoneurones. Monosynaptic EPSPs had two components mediated by AMPA/KA (78%) and NMDA (22%) receptors. Both inhibitory mediators considerably decreased EPSP's decay time by 33.4 +/- 4.0% (n = 18) for glycine and by 40.2 +/- 3.6% (n = 18) for GABA. The decrease of EPSP's decay time was reduced after blockade ofNMDA receptors by AP5. The time characteristics were recovered in the normal saline. Glycine and GABA inhibited NMDA component of EPSPs to a greater extent than AMPA/KA component. It was confirmed by our previous data about the predominant inhibitory effect of glycine and GABA on responses induced by NMDA (as compared with AMPA and KA) application to motoneurone membrane.
authors.forename: N I
authors.initials: NI
authors.lastname: Kalinina
authors.forename: G G
authors.initials: GG
authors.lastname: Kurchavyi
authors.forename: N P
authors.initials: NP
authors.lastname: Vesselkin
mesh_terms: D000818:Animals; D019706:Excitatory Postsynaptic Potentials; D005998:Glycine / Q000494:pharmacology*; D009046:Motor Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011898:Ranidae; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism; D013116:Spinal Cord / Q000166:cytology; D013569:Synapses / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D005680:gamma-Aminobutyric Acid; D005998:Glycine