title: Pregabalin reduces postoperative opioid consumption and pain for 1 week after hospital discharge, but does not affect function at 6 weeks or 3 months after total hip arthroplasty.
abstract: BACKGROUND
  This study examined whether a perioperative regimen of pregabalin added to celecoxib improved pain scores and functional outcomes postdischarge up to 3 months after total hip arthroplasty (primary outcome) and acute postoperative pain and adverse effects (secondary outcomes).
  
  
  METHODS
  One hundred and eighty-four patients were enrolled in a randomized, double-blind, placebo-controlled study. Two hours before receiving a spinal anaesthetic and undergoing surgery, patients received celecoxib 400 mg p.o. and were randomly assigned to receive either pregabalin 150 mg p.o. or placebo p.o. After surgery, patients received pregabalin 75 mg or placebo twice daily in hospital and for 7 days after discharge. Patients also received celecoxib 200 mg every 12 h for 72 h and morphine i.v. patient-controlled analgesia for 24 h. Pain and function were assessed at baseline, 6 weeks, and 3 months after surgery.
  
  
  RESULTS
  There was no difference between groups in physical function or incidence and intensity of chronic pain 3 months after total hip arthroplasty. The pregabalin group used less morphine [mean (sd): 39.85 (28.1) mg] than the placebo group [54.01 (31.2) mg] in the first 24 h after surgery (P<0.01). Pain scores were significantly lower in the pregabalin group vs the placebo group on days 1-7 after hospital discharge, and the pregabalin group required less adjunctive opioid medication (Percocet) 1 week after hospital discharge (P<0.05).
  
  
  CONCLUSIONS
  Perioperative administration of pregabalin did not improve pain or physical function at 6 weeks or 3 months after total hip arthroplasty. Perioperative administration of pregabalin decreased opioid consumption in hospital and reduced daily pain scores and adjunct opioid consumption for 1 week after discharge.
authors.affiliation: Department of Anaesthesia and Pain Management, Toronto General Hospital, Holland Orthopaedic and Arthritic Institute, 43 Wellesley Street, Toronto, Ontario, Canada M4Y 1H1 Department of Anaesthesia Department of Clinical Epidemiology and Biostatistics hance.clarke@utoronto.ca.
authors.forename: H
authors.initials: H
authors.lastname: Clarke
authors.affiliation: Department of Psychology, York University, Toronto, Ontario, Canada.
authors.forename: G M
authors.initials: GM
authors.lastname: Pagé
authors.affiliation: Department of Anesthesia, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: C J L
authors.initials: CJ
authors.lastname: McCartney
authors.affiliation: Department of Anaesthesia, University of Toronto, Toronto, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Huang
authors.affiliation: School of Rehabilitation Science Department of Clinical Epidemiology and Biostatistics.
authors.forename: P
authors.initials: P
authors.lastname: Stratford
authors.affiliation: Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Andrion
authors.affiliation: School of Rehabilitation Science.
authors.forename: D
authors.initials: D
authors.lastname: Kennedy
authors.affiliation: Department of Anaesthesia Department of Anaesthesia, University of Toronto, Toronto, Ontario, Canada.
authors.forename: I T
authors.initials: IT
authors.lastname: Awad
authors.affiliation: Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Gollish
authors.affiliation: Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Kay
authors.affiliation: Department of Anaesthesia and Pain Management, Toronto General Hospital, Holland Orthopaedic and Arthritic Institute, 43 Wellesley Street, Toronto, Ontario, Canada M4Y 1H1 Department of Anaesthesia, University of Toronto, Toronto, Ontario, Canada Department of Psychology, York University, Toronto, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Katz
mesh_terms: D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000775:Anesthesia, Spinal / Q000379:methods; D019644:Arthroplasty, Replacement, Hip / Q000534:rehabilitation*; D000068579:Celecoxib / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005080:Exercise Test / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D010149:Postoperative Pain / Q000517:prevention & control*; D010351:Patient Discharge; D018579:Patient Selection; D019990:Perioperative Care / Q000379:methods; D011184:Postoperative Period; D000069583:Pregabalin / Q000009:adverse effects / Q000627:therapeutic use*; D020127:Recovery of Function
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000069583:Pregabalin; D000068579:Celecoxib
keywords: multimodal analgesia; pain; postdischarge pain; pregabalin; total hip arthroplasty