title: Plasma Metabolic Profiles in Women are Menopause Dependent.
abstract: Menopause is an endocrinological transition that greatly affects health and disease susceptibility in middle-aged and elderly women. To gain new insights into the metabolic process of menopause, plasma metabolic profiles in 115 pre- and post-menopausal women were systematically analyzed by ultra-performance liquid chromatography/mass spectrometry in conjunction with univariate and multivariate statistical analysis. Metabolic signatures revealed considerable differences between pre- and post-menopausal women, and clear separations were observed between the groups in partial least-squares discriminant analysis score plots. In total, 28 metabolites were identified as potential metabolite markers for menopause, including up-regulated acylcarnitines, fatty acids, lysophosphatidylcholines, lysophosphatidylethanolamines, and down-regulated pregnanediol-3-glucuronide, dehydroepiandrosterone sulfate, p-hydroxyphenylacetic acid and dihydrolipoic acid. These differences highlight that significant alterations occur in fatty acid β-oxidation, phospholipid metabolism, hormone metabolism and amino acid metabolism in post-menopausal women. In conclusion, our plasma metabolomics study provides novel understanding of the metabolic profiles related to menopause, and will be useful for investigating menopause-related diseases and assessing metabolomic confounding factors.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Chaofu
authors.initials: C
authors.lastname: Ke
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Haiyu
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Jingtao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Guo
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, United States of America.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, 150086, P.R. China.
authors.forename: Kang
authors.initials: K
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002331:Carnitine / Q000031:analogs & derivatives / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D016002:Discriminant Analysis; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008244:Lysophosphatidylcholines / Q000097:blood; D008246:Lysophospholipids / Q000097:blood; D008593:Menopause / Q000097:blood*; D055442:Metabolome / Q000502:physiology*; D055432:Metabolomics; D008875:Middle Aged; D010648:Phenylacetates / Q000097:blood; D017698:Postmenopause / Q000097:blood*; D011276:Pregnanediol / Q000031:analogs & derivatives / Q000097:blood; D017697:Premenopause / Q000097:blood*; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D005227:Fatty Acids; D008244:Lysophosphatidylcholines; D008246:Lysophospholipids; D010648:Phenylacetates; C008301:lysophosphatidylethanolamine; C022270:pregnanediol-3 alpha-glucuronide; C008070:4-hydroxyphenylacetic acid; D019314:Dehydroepiandrosterone Sulfate; D008063:Thioctic Acid; C015144:dihydrolipoic acid; D011276:Pregnanediol; D002331:Carnitine