title: The prognostic value of p53 expression for patients with cervical cancer: a meta analysis.
abstract: OBJECTIVE
  A number of studies have evaluated the association of p53 expression with the cervical cancer clinical outcome, but the results were inconsistent.
  
  
  METHODS
  Electronic search of PubMed was conducted to select studies. Studies which quantitatively evaluated the relationship between p53 expression and survival of the patients with cervical cancer were chosen, and hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association.
  
  
  RESULTS
  The final meta-analysis contained 11 published studies including 1105 patients. Combined HRs suggested that p53 overexpression has an unfavorable impact on overall survival(OS) [HR=1.672, 95% confidence interval (CI): 1.144-2.444, P=0.008], and Caucasian cervical cancer patients OS[HR=1.942, 95% CI: 1.162-3.245, P=0.011].
  
  
  CONCLUSIONS
  p53 expression indicates a poor prognosis for Caucasian people with cervical cancer.
authors.affiliation: Laboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, Yunnan 650500, China.
authors.forename: Ruoyu
authors.initials: R
authors.lastname: Zhou
authors.affiliation: Laboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, Yunnan 650500, China.
authors.forename: Chuanyu
authors.initials: C
authors.lastname: Wei
authors.affiliation: Laboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, Yunnan 650500, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Laboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, Yunnan 650500, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Laboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, Yunnan 650500, China. Electronic address: twr@sina.com.
authors.forename: Wenru
authors.initials: W
authors.lastname: Tang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality; D005260:Female; D006801:Humans; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000401:mortality; D044465:White People
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
keywords: Cervical cancer; Expression; Meta-analysis; Prognosis; p53