title: Sleep Disturbances in Patients with Medical Conditions.
abstract: Sleep-wake cycle disturbances are prevalent in patients with medical conditions and frequently present as part of a symptom cluster. Sleep disturbances impair functioning and quality of life, decrease adherence to treatments of the primary medical condition, and increase morbidity and mortality. The pathophysiology of sleep disturbances in these patients involves alterations in immune and neuroendocrine function and shares common pathophysiologic pathways with comorbidities such as fatigue and depression. Emphasis is placed on the evaluation and management of medical and psychiatric comorbidities and other factors contributing to sleep problems. Primary treatments include cognitive-behavioral therapy and pharmacotherapy.
authors.affiliation: Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-6415, USA. Electronic address: jkamath@uchc.edu.
authors.forename: Jayesh
authors.initials: J
authors.lastname: Kamath
authors.affiliation: Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-6415, USA.
authors.forename: Galina
authors.initials: G
authors.lastname: Prpich
authors.affiliation: Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-6415, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Jillani
mesh_terms: D003131:Combined Modality Therapy; D019468:Disease Management; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D009422:Nervous System Diseases / Q000150:complications*; D010146:Pain / Q000150:complications*; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy
keywords: Cancer; Cognitive behavioral therapy; Comorbidities; Inflammation; Insomnia; Medical conditions; Sleep disturbances; Symptom cluster