title: Exposure to the lampricide 3-trifluoromethyl-4-nitrophenol results in increased expression of carbohydrate transporters in Saccharomyces cerevisiae.
abstract: The lampricide 3-trifluoromethyl-4-nitrophenol (TFM) is used to control sea lamprey (Petromyzon marinus) populations in freshwater lakes. Although TFM can have sublethal and lethal effects, little is known about gene expression changes with TFM exposure. Microarray analysis was used to determine differential gene expression over 4 h of exposure in Saccharomyces cerevisiae. Among the most significantly up-regulated genes were regulators of carbohydrate transport, including HXT1, HXT3, HXT4, IMA5, MIG2, and YKR075C. Environ Toxicol Chem 2016;35:1727-1732. © 2015 SETAC.
authors.affiliation: Department of Biology and Physical Education, Norwich University, Northfield, Vermont, USA.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Hinkle
authors.affiliation: Department of Biology and Physical Education, Norwich University, Northfield, Vermont, USA.
authors.forename: Chad C
authors.initials: CC
authors.lastname: Anderson
authors.affiliation: Department of Biology and Physical Education, Norwich University, Northfield, Vermont, USA.
authors.forename: Blake
authors.initials: B
authors.lastname: Forkey
authors.affiliation: Department of Biology and Physical Education, Norwich University, Northfield, Vermont, USA.|Department of Mathematics, Norwich University, Northfield, Vermont, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Griffin
authors.affiliation: Department of Biology and Physical Education, Norwich University, Northfield, Vermont, USA.
authors.forename: Kelsey
authors.initials: K
authors.lastname: Cone
authors.affiliation: Department of Biology and Physical Education, Norwich University, Northfield, Vermont, USA.
authors.forename: Carl
authors.initials: C
authors.lastname: Vitzthum
authors.affiliation: Department of Mathematics, Norwich University, Northfield, Vermont, USA.
authors.forename: Darlene
authors.initials: D
authors.lastname: Olsen
mesh_terms: D000818:Animals; D001692:Biological Transport; D050260:Carbohydrate Metabolism / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects*; D055106:Genome-Wide Association Study; D006868:Hydrolysis; D009596:Nitrophenols / Q000633:toxicity*; D048428:Petromyzon / Q000254:growth & development; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D009596:Nitrophenols; D029701:Saccharomyces cerevisiae Proteins; D014874:Water Pollutants, Chemical; C003687:3-trifluoromethyl-4-nitrophenol
keywords: 3-trifluoromethyl-4-nitrophenol; Carbohydrate transport; Gene expression; Microarray; Saccharomyces cerevisiae