title: BDNF polymorphisms are associated with schizophrenia onset and positive symptoms.
abstract: Numerous studies have showed that brain-derived neurotrophic factor (BDNF) may be involved in the pathogenesis and pathophysiology of schizophrenia. The purposes of this study were to investigate the potential association of BDNF gene polymorphisms with susceptibility to schizophrenia and the psychopathological symptoms in patients with schizophrenia in a Han Chinese population. Four polymorphisms (rs6265, rs12273539, rs10835210 and rs2030324) of the BDNF gene were analyzed in a case-control study of 1887 Han Chinese individuals (844 patients and 1043 controls). We assessed 825 patients for psychopathology using the Positive and Negative Syndrome Scale. In single marker analyses the BDNF rs10835210 mutant A allele was significantly associated with schizophrenia. Haplotype analyses revealed higher frequencies of haplotypes containing the mutant A allele of the rs10835210 in schizophrenia than controls. We also found that this polymorphism rs10835210 was associated with positive symptoms, and the patients carrying the mutational allele A showed more positive symptoms. These findings suggest the role of these BDNF gene variants in both susceptibility to schizophrenia and in clinical symptom severity.
authors.affiliation: Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China; Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: xiang.y.zhang@uth.tmc.edu.
authors.forename: Xiang Yang
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Da-Chun
authors.initials: DC
authors.lastname: Chen
authors.affiliation: Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Tan
authors.affiliation: Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Tan
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Xingguang
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Lingjun
authors.initials: L
authors.lastname: Zuo
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Jair C
authors.initials: JC
authors.lastname: Soares
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use; D044466:Asian People; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: Association; BDNF; Haplotype; Polymorphism; Schizophrenia; Symptoms