title: Antimicrobial Susceptibility Patterns Among Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in a Large Pediatric Hospital in the United Kingdom.
abstract: Of the 551 extended spectrum β-lactamase-producing isolates characterized, the MIC90 for Escherichia coli, Klebsiella spp., and Enterobacter spp. were in the susceptible range when tested against meropenem, but were in the resistant range for all other antimicrobials tested excluding E coli and Klebsiella spp. against ertapenem and ciprofloxacin, and for Enterobacter spp. against ciprofloxacin.
authors.affiliation: Department of Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Drew
authors.affiliation: Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool.
authors.forename: Emma E
authors.initials: EE
authors.lastname: Ormandy
authors.affiliation: Department of Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: Ball
authors.affiliation: Department of Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Lambert
authors.affiliation: Department of Paediatric Infectious Diseases and Immunology, Alder Hey Children's NHS Foundation Trust, Liverpool Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, UK.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Paulus
authors.affiliation: Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool.
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Williams
authors.affiliation: Department of Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, UK.
authors.forename: Nigel A
authors.initials: NA
authors.lastname: Cunliffe
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D006776:Hospitals, Pediatric; D006801:Humans; D007709:Klebsiella / Q000187:drug effects / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D006113:United Kingdom; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases
keywords: E coli; ESBL; antimicrobial resistance; extended spectrum β-lactamase; meropenem