title: A new analytical protocol for the determination of 62 endocrine-disrupting compounds in indoor air.
abstract: The objective of this study was to develop and validate a new analytical protocol for simultaneous determination of 62 semi-volatile organic compounds in both phases of indoor air. Studied compounds belong to several families: polybrominated diphenyl ethers, polychlorinated biphenyls, hexachlorobenzene, pentachlorobenzene, phthalates, polyaromatic hydrocarbons, parabens, tetrabromobisphenol A, bisphenol A, hexabromocyclododecane, triclosan, alkylphenols, alkylphenol ethoxylates, synthetic musks (galaxolide and tonalide) and pesticides (lindane and cypermethrin). A medium volume sampling system was used to collect simultaneously these endocrine-disrupting compounds (EDCs) from the gaseous and particulate phases. An accelerated solvent extraction method was optimized to obtain all EDCs in a single extract by atmospheric phase. Their extraction from the sorbents and their analysis by liquid and gas chromatography-mass spectrometry (LC/MS/MS, GC/MS and GC/MS/MS) was validated using spiked sorbents (recovery study and analytical uncertainty analysis by fully nested design). The developed protocol achieved low limits of quantification (<0.5ng m(-3)) and low uncertainty values (<5ng m(-3)) for all compounds. Once validated, the method was applied to indoor air samples from four locations (a house, an apartment, a day nursery and an office) and compared to literature to confirm its efficiency. All target EDCs were quantified in the samples and were primarily present in the gaseous phase. The major contaminants found in indoor air were, in descending order, phthalates, synthetic musks, alkylphenols and parabens.
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, EPHE, UMR 7619 Metis, 4 Place Jussieu, 75005 Paris, France. Electronic address: stephanie.laborie@upmc.fr.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Laborie
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, EPHE, UMR 7619 Metis, 4 Place Jussieu, 75005 Paris, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Moreau-Guigon
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, EPHE, UMR 7619 Metis, 4 Place Jussieu, 75005 Paris, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Alliot
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, EPHE, UMR 7619 Metis, 4 Place Jussieu, 75005 Paris, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Desportes
authors.affiliation: Université Paris Sud, CNRS, AgroParisTech, UMR 8079, ESE, F-91405 Orsay, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Oziol
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, CNRS, EPHE, UMR 7619 Metis, 4 Place Jussieu, 75005 Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Chevreuil
mesh_terms: D016902:Air Pollution, Indoor / Q000032:analysis*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002853:Chromatography, Liquid; D052244:Endocrine Disruptors / Q000032:analysis* / Q000737:chemistry; D004784:Environmental Monitoring / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry
chemical_list: D052244:Endocrine Disruptors
keywords: Endocrine disruptors; Gas chromatography; Indoor air; Liquid chromatography; Mass spectrometry