title: Central immune alterations in passive strategy following chronic defeat stress.
abstract: The relationship between stress, mood disorders and immune disorders is known, but what remains to be resolved is why certain individuals are more susceptible than others to suffer different disorders, along with the biological mechanisms that underlie these differences. The objective of this study was to analyze the changes in the expression patterns of proinflammatory cytokines in the hypothalamus, hippocampus, amygdala and prefrontal cortex after chronic defeat, depending on the coping strategy used. The expression levels of α1b and α2a adrenergic receptors and cytokine-inducible nitric oxide synthase (iNOS) in the prefrontal cortex were also measured. The results indicated that subjects with a passive coping strategy showed high levels of interleukin-6 (IL-6) and interleukin-1β (IL-1β) expression in several cerebral structures in resting conditions after 21 days of chronic stress and increases in these cytokine levels in the hippocampus following an additional stress. Low expression levels of tumour necrosis factor-alpha (TNF-α) in the prefrontal cortex in active subjects at rest and in passive subjects after an additional defeat were detected. The iNOS expression levels were lower in the prefrontal cortex of the active group at rest. With respect to adrenergic receptor expression, there were no changes as a function of stress, but there were changes as a function of coping strategy. These results indicate differences in the variables studied in terms of the coping strategy adopted, with passive subjects having a biological profile that could be considered more vulnerable to the development of stress-related disorders.
authors.affiliation: Department of Basic Psychological Processes and their Development, University of the Basque Country UPV/EHU, Avda. Tolosa 70, 20018 San Sebastian, Spain.
authors.forename: Perez-Tejada
authors.initials: PT
authors.lastname: Joana
authors.affiliation: Department of Basic Psychological Processes and their Development, University of the Basque Country UPV/EHU, Avda. Tolosa 70, 20018 San Sebastian, Spain.
authors.forename: Arregi
authors.initials: A
authors.lastname: Amaia
authors.affiliation: Department of Basic Psychological Processes and their Development, University of the Basque Country UPV/EHU, Avda. Tolosa 70, 20018 San Sebastian, Spain.
authors.forename: Azpiroz
authors.initials: A
authors.lastname: Arantza
authors.affiliation: Department of Basic Psychological Processes and their Development, University of the Basque Country UPV/EHU, Avda. Tolosa 70, 20018 San Sebastian, Spain.
authors.forename: Beitia
authors.initials: B
authors.lastname: Garikoitz
authors.affiliation: Department of Basic Psychological Processes and their Development, University of the Basque Country UPV/EHU, Avda. Tolosa 70, 20018 San Sebastian, Spain.
authors.forename: Gomez-Lazaro
authors.initials: GL
authors.lastname: Eneritz
authors.affiliation: Department of Basic Psychological Processes and their Development, University of the Basque Country UPV/EHU, Avda. Tolosa 70, 20018 San Sebastian, Spain. Electronic address: l.garmendia@ehu.es.
authors.forename: Garmendia
authors.initials: G
authors.lastname: Larraitz
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology; D000818:Animals; D001921:Brain / Q000276:immunology*; D002755:Choice Behavior / Q000502:physiology; D002908:Chronic Disease; D004291:Dominance-Subordination; D007206:Individuality; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism; D013315:Stress, Psychological / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C587672:IL1B protein, mouse; D053583:Interleukin-1beta; D015850:Interleukin-6; D012333:RNA, Messenger; D011941:Receptors, Adrenergic; D014409:Tumor Necrosis Factor-alpha; C577686:interleukin-6, mouse; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse
keywords: Adrenergic receptors; Chronic social stress; Coping; Cytokines; Stress-related disorders; iNOS