title: Intralesional Candida Antigen Immunotherapy for the Treatment of Recalcitrant and Multiple Warts in Children.
abstract: BACKGROUND
  Intralesional injection of Candida antigen appears to be an effective alternative for the treatment of warts.
  
  
  OBJECTIVE
  To determine the efficacy and safety of this treatment.
  
  
  METHODS
  We retrospectively reviewed records of all children who received intralesional injection of Candida antigen at our center from January 2008 to July 2013.
  
  
  RESULTS
  From a total of 220 patients, 156 (70.9%) had a complete response, 37 (16.8%) had a partial response, and 27 (12.2%) had no improvement. An average of 2.73 treatments was needed. Forty-seven of the patients with more than one wart (21.3%) also noted at least partial resolution of untreated warts at distant sites. Twenty-seven of the 47 patients (57.4%) had complete resolution. All treated patients experienced some discomfort at the time of the injection, but no serious side effects were reported.
  
  
  CONCLUSIONS
  We report our results using this approach in a large group of children.
  
  
  CONCLUSIONS
  Intralesional injection of Candida antigen is an effective and safe therapy for children with multiple and recalcitrant cutaneous warts.
authors.affiliation: Pediatric Dermatology Team, Dermik, Dermatologic Center, Barcelona, Spain.
authors.forename: Fania Z
authors.initials: FZ
authors.lastname: Muñoz Garza
authors.affiliation: Pediatric Dermatology Team, Dermik, Dermatologic Center, Barcelona, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Roé Crespo
authors.affiliation: Pediatric Dermatology Team, Dermik, Dermatologic Center, Barcelona, Spain.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Torres Pradilla
authors.affiliation: Pediatric Dermatology Team, Dermik, Dermatologic Center, Barcelona, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Aguilera Peirò
authors.affiliation: Pediatric Dermatology Team, Dermik, Dermatologic Center, Barcelona, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Baltà Cruz
authors.affiliation: Pediatric Dermatology Team, Dermik, Dermatologic Center, Barcelona, Spain.
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Hernández Ruiz
authors.affiliation: Pediatric Dermatology Team, Dermik, Dermatologic Center, Barcelona, Spain.
authors.forename: Eulàlia
authors.initials: E
authors.lastname: Baselga Torres
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000946:Antigens, Fungal / Q000008:administration & dosage*; D002175:Candida / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods*; D015552:Injections, Intralesional; D008297:Male; D061214:Patient Safety; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D016896:Treatment Outcome; D014860:Warts / Q000175:diagnosis / Q000628:therapy*
chemical_list: D000946:Antigens, Fungal