title: Utility of Noninvasive Markers of Fibrosis in Cholestatic Liver Diseases.
abstract: Methods of liver fibrosis assessment have changed considerably in the last 20 years, and noninvasive markers now have been recognized as major first-line tools in the management of patients with chronic viral hepatitis infection. But what about the efficiency and utility of these surrogate indices for the more uncommon chronic cholestatic liver diseases, namely primary biliary cirrhosis and primary sclerosing cholangitis? This article provides clinicians with a global overview of what is currently known in the field. Both diagnostic and prognostic aspects of noninvasive markers of fibrosis in cholestatic liver diseases are presented and discussed.
authors.affiliation: Hepatology Department, Reference Center for Chronic Inflammatory Biliary Diseases (MIVB), French Network for Childhood and Adult Rare Liver Diseases (FILFOIE), Saint-Antoine Hospital, Assistance Publique - Hôpitaux de Paris (APHP), 184 rue du Faubourg Saint-Antoine, 75571, Paris Cedex 12, France; Inserm UMR_S938, Faculty of Medicine Pierre et Marie Curie, Saint-Antoine Site, Paris 6 University, 27 rue de Chaligny, Paris 75012, France. Electronic address: christophe.corpechot@sat.aphp.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Corpechot
mesh_terms: D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D015209:Cholangitis, Sclerosing / Q000150:complications*; D054459:Elasticity Imaging Techniques; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D008105:Liver Cirrhosis, Biliary / Q000150:complications; D008279:Magnetic Resonance Imaging; D011379:Prognosis
chemical_list: D015415:Biomarkers
keywords: Elastography; Liver biopsy; Primary biliary cirrhosis; Primary sclerosing cholangitis; Prognosis; Surrogate markers