title: Effects of Reductions in Body Mass Index on the Future Osteoarthritis Burden in Canada: A Population-Based Microsimulation Study.
abstract: Osteoarthritis (OA) is the most common joint disease and a major cause of disability. Incidence and prevalence of OA are expected to increase due to population aging and increased levels of obesity. The purpose of this study was to project the effect of hypothetical interventions that change the distribution of body mass index (BMI) on OA burden in Canada.
  
  
  
  We used a microsimulation computer model of OA based on the Population Health Model platform. The model used demographic predictions for Canada and population data from an administrative database in British Columbia and national Canadian surveys.
  
  
  
  Under the base-case scenario, between 2010 and 2030, OA prevalence is expected to increase from 11.5% to 15.6% in men and 16.3% to 21.1% in women. In scenarios assuming, on average, a 0.3-, 0.5-, or 1-unit drop in BMI per year, OA prevalence in 2030 would reach 14.9%, 14.6%, and 14.2% in men and 20.3%, 19.7%, and 18.5%, in women, respectively. Under these scenarios, the proportion of new cases prevented would be 9.5%, 13.2%, and 16.7%, respectively, in men, and 9.1%, 15.2%, and 25.0% in women. Targeting only those people ages ≥50 years for weight reduction would achieve approximately 70% of the impact of a full population strategy. Targeting only the obese (BMI ≥30) would likely result in a larger benefit for men than women.
  
  
  
  Due to the aging of the population, OA will remain a major and growing health issue in Canada over the next 2 decades, regardless of the course of the obesity epidemic.
authors.affiliation: University of British Columbia, Vancouver, and Arthritis Research Canada, Richmond, British Columbia, Canada.
authors.forename: Jacek A
authors.initials: JA
authors.lastname: Kopec
authors.affiliation: Arthritis Research Canada, Richmond, British Columbia, Canada.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Sayre
authors.affiliation: Statistics Canada, Ottawa, Ontario, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Fines
authors.affiliation: Statistics Canada, Ottawa, Ontario, Canada.
authors.forename: William M
authors.initials: WM
authors.lastname: Flanagan
authors.affiliation: Statistics Canada, Ottawa, Ontario, Canada.
authors.forename: Claude
authors.initials: C
authors.lastname: Nadeau
authors.affiliation: McGill University, Montreal, Quebec, Canada.
authors.forename: Anya
authors.initials: A
authors.lastname: Okhmatovskaia
authors.affiliation: University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Wolfson
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002170:Canada / Q000453:epidemiology; D003198:Computer Simulation; D017281:Cost of Illness; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010003:Osteoarthritis / Q000453:epidemiology*; D015995:Prevalence; D055815:Young Adult