title: Effect of platelet-rich plasma in alveolar distraction osteogenesis: a controlled clinical trial.
abstract: We have evaluated the effect of the use of platelet-rich plasma in alveolar distraction osteogenesis. Fourteen patients who were partly edentulous in the anterior premaxilla region were selected and randomised into two groups (n=7 in each group). Those in the experimental group were give platelet-rich plasma at the time of distraction, and the control group had only distraction. Selected cases had defects in the alveolar ridge of more than 3mm, and a minimal bone height of 7 mm from the alveolar ridge crest to important anatomical structures. The plaque index and gingival index were recorded on days 3, 7, 14, 21, 28, 45, 60, 75, 90, and 105 postoperatively. There was a strong negative correlation between the gingival index and augmentation of bone, and a strong positive correlation between the mean gingival index and loss of bone from the transported segment. The addition of platelet-rich plasma had a protective effect on the mucosa around the distractor, which decreased the potential for complications.
authors.affiliation: Department of Periodontology and Implantology, School of Dentistry, University of Santo Amaro, São Paulo, Brazil.
authors.forename: Diogo J B
authors.initials: DJ
authors.lastname: Menezes
authors.affiliation: Department of Periodontology and Oral Implantology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
authors.forename: Jamil Awad
authors.initials: JA
authors.lastname: Shibli
authors.affiliation: Coordinator of Biotecnos - Tecnhology and Science, Santa Maria, Brazil. Electronic address: sergio.gehrke@hotmail.com.
authors.forename: Sergio Alexandre
authors.initials: SA
authors.lastname: Gehrke
authors.affiliation: Department of Periodontology and Implantology, School of Dentistry, University of Santo Amaro, São Paulo, Brazil.
authors.forename: Andréa M
authors.initials: AM
authors.lastname: Beder
authors.affiliation: Department of Periodontology and Implantology, School of Dentistry, University of Santo Amaro, São Paulo, Brazil.
authors.forename: Wilson R
authors.initials: WR
authors.lastname: Sendyk
mesh_terms: D000539:Alveolar Process; D000540:Alveolar Ridge Augmentation; D003758:Dental Implantation, Endosseous; D006801:Humans; D019857:Osteogenesis, Distraction; D053657:Platelet-Rich Plasma
keywords: Bone augmentation; Dental implants; Osteogenesis by distraction; Platelet-rich plasma