title: Controlled release of drugs from cellulose acetate matrices produced from sugarcane bagasse: monitoring by square-wave voltammetry.
abstract: In this paper, cellulose triacetate (CTA) was produced from sugarcane bagasse and used as matrices for controlled release of paracetamol. Symmetric and asymmetric membranes were obtained by formulations of CTA/dichloromethane/drug and CTA/dichloromethane/water/drug, respectively, and they were characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). Different morphologies of membranes were observed by SEM, and the incorporation of paracetamol was confirmed by lowering of the glass transition temperature (Tg) in the DSC curves. This indicates the existence of interactions between the matrix and the drug. The evaluation of drug release was based on the electrochemical monitoring of paracetamol through its oxidation at a glassy carbon electrode surface using square-wave voltammetry (SWV), which provides fast, precise and accurate in situ measurements. The studies showed a content release of 27% and 45% by the symmetric and asymmetric membranes, respectively, during 8 h.
authors.affiliation: a Instituto De Química, Universidade Federal De Uberlândia , Uberlândia , Minas Gerais , Brazil ;
authors.forename: Guimes
authors.initials: G
authors.lastname: Rodrigues Filho
authors.affiliation: a Instituto De Química, Universidade Federal De Uberlândia , Uberlândia , Minas Gerais , Brazil ;
authors.forename: Flávia
authors.initials: F
authors.lastname: Almeida
authors.affiliation: a Instituto De Química, Universidade Federal De Uberlândia , Uberlândia , Minas Gerais , Brazil ;
authors.forename: Sabrina D
authors.initials: SD
authors.lastname: Ribeiro
authors.affiliation: a Instituto De Química, Universidade Federal De Uberlândia , Uberlândia , Minas Gerais , Brazil ;
authors.forename: Thiago F
authors.initials: TF
authors.lastname: Tormin
authors.affiliation: a Instituto De Química, Universidade Federal De Uberlândia , Uberlândia , Minas Gerais , Brazil ;
authors.forename: Rodrigo A A
authors.initials: RA
authors.lastname: Muñoz
authors.affiliation: b Faculdade De Ciências Integradas Do Pontal, Universidade Federal De Uberlândia , Ituiutaba , Minas Gerais , Brazil ;
authors.forename: Rosana M N
authors.initials: RM
authors.lastname: Assunção
authors.affiliation: c Instituto De Química, Universidade Estadual Paulista "Júlio De Mesquita Filho" , Rua Francisco Degni, 55, Quitandinha , Araraquara - SP , Brazil.
authors.forename: Hernane
authors.initials: H
authors.lastname: Barud
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage; D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D055664:Electrochemical Techniques; D008567:Membranes, Artificial; D031786:Saccharum / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature
chemical_list: D018712:Analgesics, Non-Narcotic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008567:Membranes, Artificial; D000082:Acetaminophen; D002482:Cellulose; C027433:bagasse; C024671:cellulose triacetate
keywords: Cellulose acetate; controlled release; membranes; square wave voltammetry; sugarcane bagasse