title: Radionuclide Tracers for Myocardial Perfusion Imaging and Blood Flow Quantification.
abstract: Myocardial perfusion imaging is performed most commonly using Tc-99m-sestamibi or tetrofosmin SPECT as well as Rb-82-rubidium or N-13-ammonia PET. Diseased-to-normal tissue contrast is determined by the tracer retention fraction, which decreases nonlinearly with flow. Reduced tissue perfusion results in reduced tracer retention, but the severity of perfusion defects is typically underestimated by 20% to 40%. Compared to SPECT, retention of the PET tracers is more linearly related to flow, and therefore, the perfusion defects are measured more accurately using N-13-ammonia or Rb-82.
authors.affiliation: National Cardiac PET Center, Cardiac Imaging Department, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada. Electronic address: RAdeKemp@ottawaheart.ca.
authors.forename: Robert A
authors.initials: RA
authors.lastname: deKemp
authors.affiliation: National Cardiac PET Center, Cardiac Imaging Department, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Renaud
authors.affiliation: Division of Nuclear Medicine, Department of Medicine, The Ottawa Hospital, 1053 Carling Avenue, Ottawa, Ontario K1Y 4E9, Canada.
authors.forename: Ran
authors.initials: R
authors.lastname: Klein
authors.affiliation: National Cardiac PET Center, Cardiac Imaging Department, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada.
authors.forename: Rob S B
authors.initials: RS
authors.lastname: Beanlands
mesh_terms: D003326:Coronary Circulation / Q000502:physiology*; D006801:Humans; D055414:Myocardial Perfusion Imaging; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals
keywords: Coronary flow reserve; Myocardial blood flow; Myocardial perfusion imaging