title: [News in severe clinical adverse drug reactions: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)].
abstract: Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening conditions associated with significant morbidity and mortality. They are considered to be part of a spectrum of cutaneous drug reactions, differing only by their extent of skin detachment due to keratinocyte apoptosis. Drugs are assumed as the main cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in most cases. The pathophysiology is incompletely understood; however, current pathogenic models involve Fas ligand, granulysin, and cytokines. Diagnosis relies mainly on clinical signs together with the histological analysis, and treatment requires early cessation of the causative drug and supportive care. Of these conditions, herein we will review the advances in clinical, pathogenesis, and management.
authors.affiliation: Departamento de Dermatología, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., México.
authors.forename: Sylvia Aide
authors.initials: SA
authors.lastname: Martínez-Cabriales
authors.affiliation: Departamento de Dermatología, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., México.
authors.forename: Minerva
authors.initials: M
authors.lastname: Gómez-Flores
authors.affiliation: Departamento de Dermatología, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., México.
authors.forename: Jorge
authors.initials: J
authors.lastname: Ocampo-Candiani
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D053222:Fas Ligand Protein / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D016207:Cytokines; D053222:Fas Ligand Protein; C075005:GNLY protein, human