title: Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.
abstract: The deposition of aggregates of human islet amyloid polypeptide (hIAPP) has been correlated with the death of β-cells in type II diabetes mellitus. The actual molecular mechanism of cell death remains largely unknown; however, it has been postulated that the process of aggregation from monomeric hIAPP is closely involved. A possible cause of cellular toxicity may be through the disruption of structural integrity of the cell membrane by IAPP. Herein, a water-soluble curcumin derivative, CurDAc, is used to investigate the mitigation of hIAPP aggregation in the absence and presence of lipid membrane.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu.
authors.forename: Amit S
authors.initials: AS
authors.lastname: Pithadia
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu and Department of Biophysics, Bose Institute, Kolkata 700 054, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Bhunia
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamraj University, Madurai 21, India.
authors.forename: Rajendran
authors.initials: R
authors.lastname: Sribalan
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu and Biophysics Program, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Vediappen
authors.initials: V
authors.lastname: Padmini
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu and Biophysics Program, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Fierke
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu and Biophysics Program, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Ayyalusamy
authors.initials: A
authors.lastname: Ramamoorthy
mesh_terms: D002462:Cell Membrane / Q000737:chemistry*; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D058228:Islet Amyloid Polypeptide / Q000737:chemistry*; D008563:Membrane Lipids / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D066329:Protein Aggregates / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D058228:Islet Amyloid Polypeptide; D008563:Membrane Lipids; D066329:Protein Aggregates; D003474:Curcumin