title: Should we question early feminizing genitoplasty for patients with congenital adrenal hyperplasia and XX karyotype?
abstract: BACKGROUND
  There is a wide difference of opinion between the medical-surgical community and advocacy group regarding Disorders of Sexual Development (DSD) secondary to congenital adrenal hyperplasia (CAH) being ranked in the intersex category. This rupture is even more evident when the issue of genitoplasty is brought up. For physicians it is obvious and unequivocal that a person with CAH and an XX karyotype has a female gender identity, whereas associations tend to rank persons with CAH in the intersex category and advocate holding-off on surgical management.
  
  
  METHODS
  A retrospective case study vs. control group, spanning over 40years, included 21 patients who were treated in 3 different centers. Each patient and their parents were contacted independently and interviewed regarding interpersonal relationships, psychological impact of genitoplasty, gender identity and opinion on optimal care management for this disorder. Three couples controls (parent-child) per CAH patients were used and matched according to age, sex assigned at birth and ethnic origin.
  
  
  RESULTS
  Sex assigned at birth seemed to concord with the gender identity perceived by the patients in 85.7% of cases. In fact, 89.7% of patients and 100% of parents felt that feminizing genitoplasty should be performed within the first year of life. There is however a significant difference compared to controls who felt that surgical management should occur later on in life. No difference was highlighted during childhood regarding parents-child relationships or social integration. However, during adolescence, the parents-child relationship tended to be significantly more painful for the CAH group. Integrating their parenting role was significantly harder for patients in the CAH-DSD group. In the population of CAH-DSD patients who had genitoplasty the level of sexual fulfillment was not lower to the one reported by the control group.
  
  
  CONCLUSIONS
  Female sex assignment seems legitimate according to this study and the development of gender identity in these patients matches the sex assigned at birth. Resolving early on the adequacy of the genital anatomy with the sex assigned is promoted by patients as well as their parents. Proper psychomotor development and sexual satisfaction underline the absence of complications related to the surgical technique and the relevance of early surgical management.
authors.affiliation: American Memorial Hospital, Pediatric Surgery Unit, 51100 Reims France. Electronic address: aurelien.binet1@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Binet
authors.affiliation: Hopital Gatien de Clocheville, Pediatric Surgery Unit, 37000 Tours France.
authors.forename: H
authors.initials: H
authors.lastname: Lardy
authors.affiliation: CHRU Anger, Pediatric Surgery Unit, 49000 Angers France.
authors.forename: D
authors.initials: D
authors.lastname: Geslin
authors.affiliation: American Memorial Hospital, Pediatric Surgery Unit, 51100 Reims France.
authors.forename: C
authors.initials: C
authors.lastname: Francois-Fiquet
authors.affiliation: American Memorial Hospital, Pediatric Surgery Unit, 51100 Reims France.
authors.forename: M L
authors.initials: ML
authors.lastname: Poli-Merol
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000235:genetics / Q000523:psychology / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D041321:Chromosomes, Human, X; D005260:Female; D005500:Follow-Up Studies; D005783:Gender Identity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D059785:Karyotype; D008297:Male; D010287:Parent-Child Relations; D010290:Parents / Q000523:psychology; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome; D013519:Urogenital Surgical Procedures / Q000379:methods*; D055815:Young Adult
keywords: Congenital adrenal hyperplasia; Gender identity; Interpersonal relationships; Plastic surgery; Relationships between family and healthcare professionals