title: Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard.
abstract: A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a-m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.
authors.affiliation: Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar, Annaba University, BOX 12, Annaba, Algeria.
authors.forename: H
authors.initials: H
authors.lastname: Cheloufi
authors.affiliation: Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar, Annaba University, BOX 12, Annaba, Algeria.
authors.forename: B
authors.initials: B
authors.lastname: Belhani
authors.affiliation: Laboratoire de Chimie des Substances Naturelles, Université de Limoges, 123 Av. Albert Thomas, 87060, Limoges Cedex, France.
authors.forename: T S
authors.initials: TS
authors.lastname: Ouk
authors.affiliation: Laboratoire de Chimie des Substances Naturelles, Université de Limoges, 123 Av. Albert Thomas, 87060, Limoges Cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Zerrouki
authors.affiliation: Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar, Annaba University, BOX 12, Annaba, Algeria.
authors.forename: N-E
authors.initials: NE
authors.lastname: Aouf
authors.affiliation: Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar, Annaba University, BOX 12, Annaba, Algeria. malika.berredjem@univ-annaba.org.
authors.forename: M
authors.initials: M
authors.lastname: Berredjem
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008466:Mechlorethamine / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014510:Urease / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D008466:Mechlorethamine; D014510:Urease
keywords: Antitumor; Cancer; Nitrogen mustard; Sulfonamides; Sulfonylcycloureas