title: The Mononuclear Phagocyte System in Organ Transplantation.
abstract: The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells (DCs). Over the past few decades, classification of the cells of the MPS has generated considerable controversy. Recent studies into the origin, developmental requirements and function of MPS cells are beginning to solve this problem in an objective manner. Using high-resolution genetic analyses and fate-mapping studies, three main mononuclear phagocyte lineages have been defined, namely, macrophage populations established during embryogenesis, monocyte-derived cells that develop during adult life and DCs. These subsets and their diverse subsets have specialized functions that are largely conserved between species, justifying the introduction of a new, universal scheme of nomenclature and providing the framework for therapeutic manipulation of immune responses in the clinic. In this review, we have commented on the implications of this novel MPS classification in solid organ transplantation.
authors.affiliation: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: J
authors.initials: J
authors.lastname: Ochando
authors.affiliation: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: W-H
authors.initials: WH
authors.lastname: Kwan
authors.affiliation: Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Singapore, Singapore.
authors.forename: F
authors.initials: F
authors.lastname: Ginhoux
authors.affiliation: Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
authors.forename: J A
authors.initials: JA
authors.lastname: Hutchinson
authors.affiliation: Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Hashimoto
authors.affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle, UK.
authors.forename: M
authors.initials: M
authors.lastname: Collin
mesh_terms: D000328:Adult; D000818:Animals; D006801:Humans; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D016377:Organ Transplantation