title: Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora.
abstract: The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed.
authors.affiliation: Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Shi
authors.affiliation: Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan. Electronic address: szhu@inm.u-toyama.ac.jp.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Ge
authors.affiliation: Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: He
authors.affiliation: Division of Kampo-Pharmaceutics, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Kazuma
authors.affiliation: The MOE Key laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201-203, China.
authors.forename: Zhengtao
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki 305-0843, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Yoshimatsu
authors.affiliation: Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan. Electronic address: katsukok@inm.u-toyama.ac.jp.
authors.forename: Katsuko
authors.initials: K
authors.lastname: Komatsu
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015394:Molecular Structure; D039821:Monoterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D029596:Paeonia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats
chemical_list: D018926:Anti-Allergic Agents; D039821:Monoterpenes; D010936:Plant Extracts
keywords: Anti-allergic activity; Monoterpene derivatives; Paeonia lactiflora; Red peony root