title: Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar.
abstract: Seven new tetracyclic quassinoids, picrajavanicins A-G (1-7), along with three known analogues, were isolated from a CHCl3-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the cancer cells used (IC50 values >10 μM).
authors.affiliation: Institute of Natural Medicine, University of Toyama , 2630-Sugitani, Toyama 930-0194, Japan.|Department of Chemistry, University of Yangon , Yangon 11041, Myanmar.
authors.forename: Nwet Nwet
authors.initials: NN
authors.lastname: Win
authors.affiliation: Institute of Natural Medicine, University of Toyama , 2630-Sugitani, Toyama 930-0194, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Ito
authors.affiliation: Faculty of Pharmacy, Hasanuddin University , Makassar 90245, South Sulawesi, Indonesia.
authors.lastname: Ismail
authors.affiliation: Institute of Natural Medicine, University of Toyama , 2630-Sugitani, Toyama 930-0194, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kodama
authors.affiliation: Department of Chemistry, University of Yangon , Yangon 11041, Myanmar.
authors.forename: Yi Yi
authors.initials: YY
authors.lastname: Win
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Department of Chemistry, University of Yangon , Yangon 11041, Myanmar.
authors.forename: Hla
authors.initials: H
authors.lastname: Ngwe
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Ikuro
authors.initials: I
authors.lastname: Abe
authors.affiliation: Institute of Natural Medicine, University of Toyama , 2630-Sugitani, Toyama 930-0194, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morita
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D002052:Myanmar; D019906:Nuclear Magnetic Resonance, Biomolecular; D032270:Picrasma / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D036702:Quassins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036702:Quassins