title: In Vitro Effect of Laser-Induced Hydrodynamics on Cancer Cells.
abstract: We studied the effect of laser-induced hydrodynamic on viability of Colo-26 murine colon carcinoma cells in vitro. Laser-induced hydrodynamics was generated by a laser (λ=1.56 μ, power 3 W, 5 min exposure); to this end, the fiber end was submersed into a buffer above the cell monolayer. It was found that laser-induced hydrodynamics destructed the monolayer at standoff distances of between the working end of the laser fiber to cell monolayer of 1 and 5 mm and triggers apoptotic and necrotic death in remaining cells at a distance of 4 mm from the emitter.
authors.affiliation: Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia. elagin.vadim@gmail.com.
authors.forename: V V
authors.initials: VV
authors.lastname: Elagin
authors.affiliation: Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Pavlikov
authors.affiliation: Institute of Laser and Information Technologies, Russian Academy of Sciences, Moscow, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Yusupov
authors.affiliation: Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Shirmanova
authors.affiliation: Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Zagaynova
authors.affiliation: Institute of Laser and Information Technologies, Russian Academy of Sciences, Moscow, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Bagratashvili
mesh_terms: D000818:Animals; D017209:Apoptosis; D002277:Carcinoma / Q000473:pathology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000473:pathology*; D005336:Fiber Optic Technology / Q000295:instrumentation / Q000379:methods*; D057446:Hydrodynamics; D066298:In Vitro Techniques; D053685:Laser Therapy / Q000295:instrumentation / Q000379:methods; D007834:Lasers; D051379:Mice; D045423:Microbubbles; D009336:Necrosis; D013696:Temperature; D014741:Video Recording
keywords: apoptosis; laser radiation; laser-induced hydrodynamics; necrosis