title: Physiologic Status Monitoring via the Gastrointestinal Tract.
abstract: Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, we developed an approach that enables vital sign monitoring internally from the gastrointestinal tract. Here we report initial proof-of-concept large animal (porcine) experiments and a robust processing algorithm that demonstrates the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage.
authors.affiliation: Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.|Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
authors.forename: G
authors.initials: G
authors.lastname: Traverso
authors.affiliation: Bioengineering Systems and Technologies, Massachusetts Institute of Technology Lincoln Laboratory, Lexington, MA, 02420, United States of America.
authors.forename: G
authors.initials: G
authors.lastname: Ciccarelli
authors.affiliation: Bioengineering Systems and Technologies, Massachusetts Institute of Technology Lincoln Laboratory, Lexington, MA, 02420, United States of America.
authors.forename: S
authors.initials: S
authors.lastname: Schwartz
authors.affiliation: Bioengineering Systems and Technologies, Massachusetts Institute of Technology Lincoln Laboratory, Lexington, MA, 02420, United States of America.
authors.forename: T
authors.initials: T
authors.lastname: Hughes
authors.affiliation: Bioengineering Systems and Technologies, Massachusetts Institute of Technology Lincoln Laboratory, Lexington, MA, 02420, United States of America.
authors.forename: T
authors.initials: T
authors.lastname: Boettcher
authors.affiliation: Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.|Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
authors.forename: R
authors.initials: R
authors.lastname: Barman
authors.affiliation: Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
authors.forename: R
authors.initials: R
authors.lastname: Langer
authors.affiliation: Bioengineering Systems and Technologies, Massachusetts Institute of Technology Lincoln Laboratory, Lexington, MA, 02420, United States of America.
authors.forename: A
authors.initials: A
authors.lastname: Swiston
mesh_terms: D000465:Algorithms; D000818:Animals; D004386:Duodenum; D004947:Esophagus; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D018670:Monitoring, Ambulatory / Q000295:instrumentation / Q000379:methods*; D056152:Respiratory Rate / Q000502:physiology*; D013270:Stomach; D013552:Swine; D017216:Telemedicine / Q000295:instrumentation; D059015:Wireless Technology / Q000295:instrumentation*