title: Oral candidiasis following steroid therapy for oral lichen planus.
abstract: OBJECTIVE
  The purpose of this multicentre study was to determine the incidence of oral candidiasis in patients treated with topical steroids for oral lichen planus (OLP) and to determine whether the application of a concurrent antifungal therapy prevented the development of an oral candidiasis in these patients.
  
  
  METHODS
  Records of 315 patients with OLP seen at four Oral Medicine practices treated for at least 2 weeks with steroids with and without the use of an antifungal regimen were retrospectively reviewed.
  
  
  RESULTS
  The overall incidence of oral fungal infection in those treated with steroid therapy for OLP was 13.6%. There was no statistically significant difference in the rate of oral candidiasis development in those treated with an antifungal regimen vs those not treated prophylactically (14.3% vs 12.6%) (P = 0.68).
  
  
  CONCLUSIONS
  Despite the use of various regimens, none of the preventive antifungal strategies used in this study resulted in a significant difference in the rate of development of an oral candidiasis in patients with OLP treated with steroids.
authors.affiliation: Department of Oral Medicine, Carolinas Healthcare System, Charlotte, NC, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Marable
authors.affiliation: Department of Oral Medicine, Carolinas Healthcare System, Charlotte, NC, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Bowers
authors.affiliation: Department of Oral Medicine, Carolinas Healthcare System, Charlotte, NC, USA.
authors.forename: T L
authors.initials: TL
authors.lastname: Stout
authors.affiliation: Oral & Maxillofacial Surgery and Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Stewart
authors.affiliation: Oral & Maxillofacial Surgery and Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Berg
authors.affiliation: Department of Comprehensive Dentistry, University of Texas Health Science Center School of Dentistry, San Antonio, TX, USA.
authors.forename: V
authors.initials: V
authors.lastname: Sankar
authors.affiliation: Oral Health and Diagnostic Sciences, Georgia Regents University - College of Dental Medicine, Augusta, GA, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: DeRossi
authors.affiliation: Oral Health and Diagnostic Sciences, Georgia Regents University - College of Dental Medicine, Augusta, GA, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Thoppay
authors.affiliation: Department of Oral Medicine, Carolinas Healthcare System, Charlotte, NC, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Brennan
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D001623:Betamethasone / Q000008:administration & dosage; D002180:Candidiasis, Oral / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D003022:Clotrimazole / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D005447:Fluocinonide / Q000008:administration & dosage; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D017676:Lichen Planus, Oral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D005938:Glucocorticoids; C452620:Lotrisone; D005447:Fluocinonide; D003907:Dexamethasone; D001623:Betamethasone; D003022:Clotrimazole
keywords: oral candidiasis; oral lichen planus; steroids