title: Bio-guided Isolation of a New Sesterterpene from Serjania goniocarpa.
abstract: Serjania goniocarpa is a plant used in Mayan traditional medicine as a remedy for the treatment of cancer-like symptoms. Bio-guided fractionation of the methanol extract of the leaves led to the isolation of an α- and β-amyrin mixture, palmitic acid, phytol and the new sesterterpene goniocarpic acid whose structure was elucidated by IR, GC-MS, and NMR spectroscopic analyses. Goniocarpic acid exhibited cytotoxic and antiproliferative activity against several cancer cell lines.
authors.forename: Carlos
authors.initials: C
authors.lastname: Quintal-Novelo
authors.forename: Luis W
authors.initials: LW
authors.lastname: Torres-Tapia
authors.forename: Rosa
authors.initials: R
authors.lastname: Moo-Puc
authors.forename: Sergio R
authors.initials: SR
authors.lastname: Peraza-Sanchez
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D008519:Medicine, Traditional; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D029631:Sapindaceae / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification*; D054830:Sesterterpenes / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D010936:Plant Extracts; D012717:Sesquiterpenes; D054830:Sesterterpenes; C000603640:goniocarpic acid; D009828:Oleanolic Acid; C036380:beta-amyrin