title: Aptamers Selected by Cell-SELEX for Molecular Imaging.
abstract: Conventional diagnostics for cancer rely primarily on anatomical techniques. However, these techniques cannot monitor the changes at the molecular level in normal cells, which possibly signal the onset of cancer at its very earliest stages. For accurate prediction of the carcinogenesis at the molecular level, targeting ligands have been used in combination with imaging probes to monitor this biological process. Among these targeting ligands, aptamers have high binding affinity to various targets ranging from small molecules to whole organisms, and, hence, exceptional recognition ability. Many recent studies have been reported on aptamer-based molecular imaging, clearly indicating its clinical and diagnostic utility. In this review, we will discuss some key results of these studies.
authors.affiliation: Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, 410082, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Jin
authors.affiliation: Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, 410082, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Li
authors.affiliation: Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, 410082, China.|Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, 32611-7200, USA.
authors.forename: Liping
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, 410082, China. xbzhang@hnu.edu.cn.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, 410082, China. tan@chem.ufl.edu.|Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, 32611-7200, USA. tan@chem.ufl.edu.
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide; D006801:Humans; D008279:Magnetic Resonance Imaging; D057054:Molecular Imaging; D009369:Neoplasms / Q000175:diagnosis*; D061848:Optical Imaging; D052156:SELEX Aptamer Technique / Q000379:methods*
chemical_list: D052157:Aptamers, Nucleotide
keywords: Aptamer; Cancer; Molecular imaging; SELEX; Targeting ligands