title: Renal Failure in Pregnancy.
abstract: Renal failure during pregnancy affects both mother and fetus, and may be related to preexisting disease or develop secondary to diseases of pregnancy. Causes include hypovolemia, sepsis, shock, preeclampsia, thrombotic microangiopathies, and renal obstruction. Treatment focuses on supportive measures, while pharmacologic treatment is viewed as second-line therapy, and is more useful in mitigating harmful effects than treating the underlying cause. When supportive measures and pharmacotherapy prove inadequate, dialysis may be required, with the goal being to prolong pregnancy until delivery is feasible. Outcomes and recommendations depend primarily on the underlying cause.
authors.affiliation: Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood, Box 604, Rochester, NY 14642, USA.
authors.forename: Ari
authors.initials: A
authors.lastname: Balofsky
authors.affiliation: Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood, Box 604, Rochester, NY 14642, USA. Electronic address: Maksim_Fedarau@URMC.Rochester.edu.
authors.forename: Maksim
authors.initials: M
authors.lastname: Fedarau
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D017582:Renal Replacement Therapy / Q000379:methods* / Q000592:standards; D013520:Urologic Surgical Procedures / Q000379:methods* / Q000592:standards
keywords: Acute fatty liver of pregnancy; Dialysis; HELLP; Preeclampsia; Pregnancy; Renal failure; Thrombotic microangiopathies