title: Study of Subchronic Toxicity of Relatox on Sexually Immature Animals.
abstract: Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation (inflammation, atrophy, and sclerosis in muscle tissue). Regeneration processes started in muscle tissue 7 days after Relatox withdrawal.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. toxicology_lab@mail.ru.
authors.forename: A A
authors.initials: AA
authors.lastname: Churin
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Ermolaeva
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Vetoshkina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: T Yu
authors.initials: TY
authors.lastname: Dubskaya
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: T Yu
authors.initials: TY
authors.lastname: Lamzina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Fedorova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Neupokoeva
authors.affiliation: Microgen Research-and-Production Center for Medical and Immunobiological Drugs, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Nikiforova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001284:Atrophy; D019274:Botulinum Toxins, Type A / Q000494:pharmacology / Q000633:toxicity*; D004338:Drug Combinations; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D006388:Hemagglutinins / Q000494:pharmacology / Q000633:toxicity*; D006614:Hindlimb; D007273:Injections, Intramuscular; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D009210:Myofibrils / Q000187:drug effects / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010291:Paresis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D012038:Regeneration; D012741:Sexual Maturation; D014781:Viscera / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D006388:Hemagglutinins; D019274:Botulinum Toxins, Type A
keywords: Relatox; botulinum toxin A; preclinical studies; subchronic toxicity; young rats