title: Chromosomal Abnormalities in Embryonic and Somatic Stem Cells.
abstract: The potential use of stem cells (SCs) for tissue engineering, regenerative medicine, disease modeling, toxicological studies, drug delivery, and as in vitro model for the study of basic developmental processes implies large-scale in vitro culture. Here, after a brief description of the main techniques used for karyotype analysis, we will give a detailed overview of the chromosome abnormalities described in pluripotent (embryonic and induced pluripotent SCs) and somatic SCs, and the possible causes of their origin during culture.
authors.affiliation: Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia e Biotecnologie, Universitx00E0; degli Studi di Pavia, Pavia, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Rebuzzini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zuccotti
authors.forename: Carlo A
authors.initials: CA
authors.lastname: Redi
authors.forename: Silvia
authors.initials: S
authors.lastname: Garagna
mesh_terms: D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D055028:Comparative Genomic Hybridization; D053595:Embryonic Stem Cells / Q000378:metabolism / Q000473:pathology*; D066026:Endothelial Progenitor Cells / Q000378:metabolism / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism / Q000473:pathology*; D007621:Karyotyping; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000473:pathology; D051379:Mice; D058953:Neural Stem Cells / Q000378:metabolism / Q000473:pathology