title: Accelerated cellular on- and off-target screening of bioactive compounds using microarrays.
abstract: In situ proteome labeling was carried out with 9 drug-like probes in live mammalian cells, with the corresponding cellular targets captured on microarrays and simultaneously screened using a diverse set of antibodies, revealing potential on- and off-targets.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore. chmyaosq@nus.edu.sg.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Fu
authors.forename: Zhenkun
authors.initials: Z
authors.lastname: Na
authors.forename: Bo
authors.initials: B
authors.lastname: Peng
authors.forename: Mahesh
authors.initials: M
authors.lastname: Uttamchandani
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D000906:Antibodies / Q000276:immunology; D056945:Hep G2 Cells; D006801:Humans; D015335:Molecular Probes / Q000032:analysis* / Q000276:immunology / Q000378:metabolism*; D015394:Molecular Structure; D040081:Protein Array Analysis; D019704:Protein Disulfide-Isomerases / Q000032:analysis / Q000276:immunology / Q000378:metabolism; D011494:Protein Kinases / Q000032:analysis / Q000276:immunology / Q000378:metabolism; D020543:Proteome / Q000032:analysis* / Q000276:immunology / Q000378:metabolism*
chemical_list: D000906:Antibodies; D015335:Molecular Probes; D020543:Proteome; D011494:Protein Kinases; D019704:Protein Disulfide-Isomerases