title: Effects of in vivo exposure to polyfluorinated dibenzo-p-dioxins on organo-somatic indices and ethoxyresorufin-O-deethylase activity in mice (Mus musculus).
abstract: In this study, five different congeners of polyfluorinated dibenzo-P-dioxins (PFDDs) (1,8-di-FDD, 1,3,8-tri-FDD, 1,3,6,8-tetra-FDD, 2,3,7,8-tetra-FDD and 1,2,3,4,5,6,7,8-octa-FDD), representing different numbers and positions of fluorine substituents of all 75 PFDD congeners, were synthesized and purified to evaluate their potential environmental impact on living organisms. Their toxicity was evaluated by determining the impact on the organo-somatic indices (OSI) and ethoxyresorufin-O-deethylase (EROD) activity in mice (Mus musculus) after intragastric administration with different doses (0.5-100 μg/kg body weight) for 3 days. The results showed that these PFDDs significantly inhibited the growth and changed the OSI in mouse tissues. Notably, hepatic EROD activity was markedly induced in mice after exposure to these PFDDs, probably indicating a high affinity of binding to the aryl hydrocarbon receptor. Overall, these findings provided some preliminary but alarming toxicity data of PFDDs, and filled information gaps in the toxicological databases for living organisms.
authors.affiliation: a State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University , Jiangsu Nanjing , P.R. China.
authors.forename: Mingbao
authors.initials: M
authors.lastname: Feng
authors.affiliation: b School of Life and Chemistry, Jiangsu Second Normal University , Nanjing , Jiangsu , P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Jin
authors.affiliation: a State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University , Jiangsu Nanjing , P.R. China.
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Qu
authors.affiliation: a State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University , Jiangsu Nanjing , P.R. China.
authors.forename: Bingzhe
authors.initials: B
authors.lastname: Xu
authors.affiliation: a State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University , Jiangsu Nanjing , P.R. China.
authors.forename: Zunyao
authors.initials: Z
authors.lastname: Wang
keywords: EROD activity; Mus musculus; PFDDs; organo-somatic index; synthesis