title: Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.
abstract: Since reports on the clinical significance of legumain in cancer have shown inconsistent results, we systematically evaluated clinical indicators of legumain in cancer. We searched the Cochrane Library, PubMed, Embase, and EBSCO databases and the Wangfang and CNKI databases in China by using "legumain" and ("neoplasms" OR "cancer") as search terms. We included case-controlled studies of legumain and cancer. The quality of the studies was evaluated by using Lichtenstein's guidelines, and valid data was extracted for analysis. In total, 10 articles were included in this study. Meta-analysis showed that legumain was overexpressed in cancer compared with in normal tissue and was higher in stage III-IV disease than in I-II disease. Moreover, legumain overexpression was correlated with poor prognosis and clinical stage. Furthermore, Cancer Genome Atlas data showed that among patients with rectal cancer, those with tumors overexpressing legumain had shorter overall survival than those in the low expression group (P < 0.05). Legumain appears to be involved in tumor development and deterioration; thus, it can potentially be developed into both a marker for monitoring and diagnosing tumors and a therapeutic target.
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhen
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Chunlei
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Wenzhi
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Shuangtao
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Luo
authors.initials: L
authors.lastname: Na
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Rongrong
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Luo
authors.initials: L
authors.lastname: Xiaohe
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Niu
authors.initials: N
authors.lastname: Haiying
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Luo
authors.initials: L
authors.lastname: Dehong
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Shan
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Tan
authors.initials: T
authors.lastname: Xiaoyue
authors.affiliation: Department of Tumor Molecular Biology, Nankai University School of Medicine, Tianjin 371000, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Rong
mesh_terms: D002454:Cell Differentiation; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology*; D016017:Odds Ratio; D000099240:Asparaginyl Endopeptidase
chemical_list: D003546:Cysteine Endopeptidases; D000099240:Asparaginyl Endopeptidase