title: Digital Breast Tomosynthesis: State of the Art.
abstract: This topical review on digital breast tomosynthesis (DBT) is provided with the intent of describing the state of the art in terms of technology, results from recent clinical studies, advanced applications, and ongoing efforts to develop multimodality imaging systems that include DBT. Particular emphasis is placed on clinical studies. The observations of increase in cancer detection rates, particularly for invasive cancers, and the reduction in false-positive rates with DBT in prospective trials indicate its benefit for breast cancer screening. Retrospective multireader multicase studies show either noninferiority or superiority of DBT compared with mammography. Methods to curtail radiation dose are of importance. (©) RSNA, 2015.
authors.affiliation: From the Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655 (S.V., A.K., G.R.V.); and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (D.B.K.).
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Vedantham
authors.affiliation: From the Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655 (S.V., A.K., G.R.V.); and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (D.B.K.).
authors.forename: Andrew
authors.initials: A
authors.lastname: Karellas
authors.affiliation: From the Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655 (S.V., A.K., G.R.V.); and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (D.B.K.).
authors.forename: Gopal R
authors.initials: GR
authors.lastname: Vijayaraghavan
authors.affiliation: From the Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655 (S.V., A.K., G.R.V.); and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (D.B.K.).
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Kopans
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011829:Radiation Dosage; D011856:Radiographic Image Enhancement / Q000379:methods*; D012189:Retrospective Studies