title: Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell.
abstract: In this issue, Tosoni et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505037) report that cell fate determinant and tumor suppressor Numb imposes asymmetric cell divisions in mammary stem cells by regulating p53. Numb thereby restricts mammary stem cell expansion and controls the proliferation and lineage-specific characteristics of their progeny.
authors.affiliation: Institut Curie, PSL Research University, F-75248 Paris, France Centre National de la Recherche Scientifique, UMR144, F-75248 Paris, France Institut National de la Santé et de la Recherche Médicale, F-75013 Paris, France.
authors.forename: Marisa M
authors.initials: MM
authors.lastname: Faraldo
authors.affiliation: Institut Curie, PSL Research University, F-75248 Paris, France Centre National de la Recherche Scientifique, UMR144, F-75248 Paris, France Institut National de la Santé et de la Recherche Médicale, F-75013 Paris, France Marina.Glukhova@curie.fr.
authors.forename: Marina A
authors.initials: MA
authors.lastname: Glukhova
mesh_terms: D000818:Animals; D000066673:Cell Self Renewal; D004847:Epithelial Cells / Q000502:physiology*; D005260:Female; D008565:Membrane Proteins / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D016159:Tumor Suppressor Protein p53