title: Reproducibility of optical coherence tomography airway imaging.
abstract: Optical coherence tomography (OCT) is a promising imaging technique to evaluate small airway remodeling. However, the short-term insertion-reinsertion reproducibility of OCT for evaluating the same bronchial pathway has yet to be established. We evaluated 74 OCT data sets from 38 current or former smokers twice within a single imaging session. Although the overall insertion-reinsertion airway wall thickness (WT) measurement coefficient of variation (CV) was moderate at 12%, much of the variability between repeat imaging was attributed to the observer; CV for repeated measurements of the same airway (intra-observer CV) was 9%. Therefore, reproducibility may be improved by introduction of automated analysis approaches suggesting that OCT has potential to be an in-vivo method for evaluating airway remodeling in future longitudinal and intervention studies.
authors.affiliation: Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada ; Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Miranda
authors.initials: M
authors.lastname: Kirby
authors.affiliation: Department of Surgery, Tokyo Medical University, Tokyo, Japan.
authors.forename: Keishi
authors.initials: K
authors.lastname: Ohtani
authors.affiliation: Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.
authors.forename: Taylor
authors.initials: T
authors.lastname: Nickens
authors.affiliation: Department of Respirology, Bellvitge University Hospital, l'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Rosa Maria Lopez
authors.initials: RM
authors.lastname: Lisbona
authors.affiliation: Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada.
authors.forename: Anthony M D
authors.initials: AM
authors.lastname: Lee
authors.affiliation: Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada.
authors.forename: Tawimas
authors.initials: T
authors.lastname: Shaipanich
authors.affiliation: Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lane
authors.affiliation: Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada.
authors.forename: Calum
authors.initials: C
authors.lastname: MacAulay
authors.affiliation: Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada ; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Lam
authors.affiliation: Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada ; Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Harvey O
authors.initials: HO
authors.lastname: Coxson
keywords: (170.0170) Medical optics and biotechnology; (170.4500) Optical coherence tomography