title: Association between angiotensinogen T174M polymorphism and ischemic stroke: A meta-analysis.
abstract: BACKGROUND
  Numerous studies have evaluated the association between the angiotensinogen (AGT) T174M polymorphism and ischemic stroke(IS) risk. However, the specific association is still controversial.
  
  
  METHODS
  In order to explore this association more deeply, we performed a meta-analysis. All of the relevant studies were identified from PubMed, Embase, and Chinese National Knowledge Infrastructure database up to October 2014. Statistical analyses were conducted with STATA 12.0 software. Odds ratio (OR) with 95% confidence interval (CI) values were applied to evaluate the strength of the association.
  
  
  RESULTS
  Six studies with 1290 cases and 1125 controls were included. No significant variation in IS risk was detected in any of the genetic models in the overall (MM vs. TT: OR = 1.64, 95% CI = 0.51-5.28; MT vs. TT: OR = 0.93, 95% CI = 0.66-1.31; dominant model: OR = 1.08, 95% CI = 0.69-1.72; recessive model: OR = 0.61,95% CI = 0.20-1.91). Taking into account the effect of ethnicity, further stratified analyses were performed. The results showed that AGT gene T174M polymorphism might be associated with IS risk in Asians (MM vs. TT: OR = 3.28, 95% CI = 1.79-6.02; recessive model: OR = 0.31, 95% CI = 0.17-0.57).
  
  
  CONCLUSIONS
  In conclusion, the AGT T174M polymorphism may be a susceptible predictor of the risk of IS in Asians. Further, large and well-designed studies are needed to confirm this conclusion.
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, P.R. China.
authors.forename: Zilin
authors.initials: Z
authors.lastname: Ou
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, P.R. China.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Neurology, Guangzhou Number 8 People's Hospital of Guangzhou Medical University, Guangzhou 510440, P.R. China.
authors.forename: Chuo
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, P.R. China.
authors.forename: Shaoying
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, P.R. China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Lin
keywords: Angiotensinogen gene; T174M polymorphism; ischemic stroke; meta-analysis