title: Two cases of gastrointestinal stromal tumor of the small intestine with liver and bone metastasis.
abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. These tumors most commonly occur in the stomach (60%), jejunum and ileum (30%). Metastasis is characteristically the malignant behavior of the GISTs. GISTs most frequently metastasize to the liver and peritoneum, whereas bone and lung metastases are uncommon sites. Here, we described two cases of bone and liver metastases in patients with advanced GISTs. Both of them showed liver metastasis at disease presentation and bone metastasis in early time after the diagnosis. Bone metastases involved the lumber spine and right femur in first patient and L2 vertebral body in the second case. All of the lesions presented a lytic pattern. These cases are presented because of the rare incidence of bone metastasis to femur and vertebral bodies. More attention should be paid to the diagnosis of bone metastases from GISTs in clinical practice despite the shortage of available data on the sensitivity and specificity of bone scintigraphy and PET-CT.
authors.affiliation: Meram Faculty of Medicine, Department of Radiation Oncology, Necmettin Erbakan University, 42090 Konya, Turkey.
authors.forename: Meryem
authors.initials: M
authors.lastname: Aktan
authors.affiliation: Meram Faculty of Medicine, Department of Radiation Oncology, Necmettin Erbakan University, 42090 Konya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Koc
authors.affiliation: Meram Faculty of Medicine, Department of Radiation Oncology, Necmettin Erbakan University, 42090 Konya, Turkey.
authors.forename: Berrin Benli
authors.initials: BB
authors.lastname: Yavuz
authors.affiliation: Meram Faculty of Medicine, Department of Radiation Oncology, Necmettin Erbakan University, 42090 Konya, Turkey.
authors.forename: Gul
authors.initials: G
authors.lastname: Kanyilmaz
keywords: Gastrointestinal stromal tumor (GIST); bone; metastasis