title: Relationship Between Cerebrospinal Fluid Protein Levels and Electrophysiologic Abnormalities in Guillain-Barré Syndrome.
abstract: OBJECTIVE
  The cerebrospinal fluid (CSF) protein level is known to be elevated in patients with Guillain-Barré syndrome (GBS). This report correlates the degree of CSF protein elevation with the number of electrophysiologic abnormalities on nerve conduction study (NCS).
  
  
  METHODS
  We reviewed 38 patients admitted to our institution with a diagnosis of GBS and had both a measured CSF protein level and a NCS within 24 hours of each other.
  
  
  RESULTS
  CSF protein level correlates with the number of NCS demyelination criteria, as described by Cornblath, in patients with GBS.
  
  
  CONCLUSIONS
  This retrospective study is the first to demonstrate a relationship between the CSF protein level and the electrophysiologic abnormalities that accompany GBS.
authors.affiliation: *Department of Neurology, Yale University School of Medicine, New Haven, CT; †Department of Neurology, Medical College of Wisconsin, Milwaukee, WI; and ‡Department of Neurology, Hospital for Special Surgery, New York, NY.
authors.forename: Daniel B
authors.initials: DB
authors.lastname: DiCapua
authors.forename: Amanda A
authors.initials: AA
authors.lastname: Lakraj
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Nowak
authors.forename: Kimberly
authors.initials: K
authors.lastname: Robeson
authors.forename: Jonathan
authors.initials: J
authors.lastname: Goldstein
authors.forename: Huned
authors.initials: H
authors.lastname: Patwa
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D004594:Electrophysiology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D011506:Proteins