title: Homeotic Transformations of Neuronal Cell Identities.
abstract: Homeosis is classically defined as the transformation of one body part into something that resembles another body part. We propose here to broaden the concept of homeosis to the many neuronal cell identity transformations that have been uncovered over the past few years upon removal of specific regulatory factors in organisms from Caenorhabditis elegans to Drosophila, zebrafish, and mice. The concept of homeosis provides a framework for the evolution of cell type diversity in the brain.
authors.affiliation: Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: Paola_Arlotta@harvard.edu.
authors.forename: Paola
authors.initials: P
authors.lastname: Arlotta
authors.affiliation: Department of Biology and Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY, USA. Electronic address: or38@columbia.edu.
authors.forename: Oliver
authors.initials: O
authors.lastname: Hobert
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D005075:Biological Evolution; D001921:Brain / Q000502:physiology; D006801:Humans; D009024:Morphogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010944:Plants