title: Effect of Decitabine Combined with Unrelated Cord Blood Transplantation in an Adult Patient with -7/EVI1+ Acute Myeloid Leukemia: a Case Report and Literature Review.
abstract: Patients with relapsed or refractory acute myeloid leukemia (rAML) have a poor prognosis if they do not undergo hematopoietic stem cell transplantation (HSCT). We describe a case herein of acute myeloid leukemia (AML) with monosomy 7 and EVI1(+)(-7/EVI1(+)) in a patient who failed to achieve a complete remission (CR) after two cycles of standard induction chemotherapy. He subsequently received decitabine (DAC) as "bridge therapy" and directly underwent unrelated cord blood transplantation (UCBT) due to the absence of an available sibling donor. Although DAC treatment did not induce CR, it did produce hematologic improvement and control disease progression with acceptable side effects, thus effectively bridging the time of donor search. Following UCBT, the marrow showed complete hematologic and cytogenetic remission. At present, 18 months after the transplantation, the patient's general condition is still good.
authors.affiliation: Department of Hematology, the Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China.
authors.forename: Yi-Zhi
authors.initials: YZ
authors.lastname: Jiang
authors.affiliation: Department of Hematology, the Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China.
authors.forename: Gui-Ping
authors.initials: GP
authors.lastname: Su
authors.affiliation: Department of Hematology, the Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Hematology, the Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China.
authors.forename: He-Sheng
authors.initials: HS
authors.lastname: He
authors.affiliation: Department of Hematology, the Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China.
authors.forename: Lai-Quan
authors.initials: LQ
authors.lastname: Huang
authors.affiliation: Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
authors.forename: Zi-Min
authors.initials: ZM
authors.lastname: Sun
authors.affiliation: Department of Hematology, the Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China hdp0513@163.com.
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Huang
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D004268:DNA-Binding Proteins / Q000235:genetics; D000077209:Decitabine; D005312:Fetal Blood / Q000637:transplantation; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D060828:Induction Chemotherapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy*; D000074008:MDS1 and EVI1 Complex Locus Protein; D008297:Male; D011519:Proto-Oncogenes / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D014184:Transplantation, Homologous / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000964:Antimetabolites, Antineoplastic; D004268:DNA-Binding Proteins; D000074008:MDS1 and EVI1 Complex Locus Protein; C063575:MECOM protein, human; D014157:Transcription Factors; D000077209:Decitabine; D001374:Azacitidine
keywords: EVI1; decitabine; monosomy of chromosome 7; relapsed or refractory acute myeloid leukemia; unrelated cord blood transplantation