title: TERRA and the state of the telomere.
abstract: Long noncoding telomeric repeat-containing RNA (TERRA) has been implicated in telomere maintenance in a telomerase-dependent and a telomerase-independent manner during replicative senescence and cancer. TERRA's proposed activities are diverse, thus making it difficult to pinpoint the critical roles that TERRA may have. We propose that TERRA orchestrates different activities at chromosome ends in a manner that depends on the state of the telomere.
authors.affiliation: Research Group Genome Organization &Function, Deutsches Krebsforschungszentrum (DKFZ) and Bioquant Center, Heidelberg, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Rippe
authors.affiliation: Institute of Molecular Biology (IMB), Mainz, Germany.
authors.forename: Brian
authors.initials: B
authors.lastname: Luke
mesh_terms: D056890:Eukaryota / Q000502:physiology*; D008954:Models, Biological; D022661:RNA, Untranslated / Q000378:metabolism*; D019098:Telomerase / Q000378:metabolism*; D059505:Telomere Homeostasis
chemical_list: D022661:RNA, Untranslated; D019098:Telomerase