title: Plasmonic fluorescent CdSe/Cu2S hybrid nanocrystals for multichannel imaging and cancer directed photo-thermal therapy.
abstract: A simple, crude Jatropha curcas (JC) oil-based synthesis approach, devoid of any toxic phosphine and pyrophoric ligands, to produce size and shape tuned CdSe QDs and a further copper sulfide (Cu2S) encasing is presented. The QDs exhibited excellent photoluminescent properties with narrow band gap emission. Furthermore, the Cu2S shell rendered additional cytocompatibility and stability to the hybrid nanomaterial, which are major factors for translational and clinical applications of QDs. The nanocomposites were PEGylated and folate conjugated to augment their cytoamiability and enhance their specificity towards cancer cells. The nanohybrids possess potentials for visible, near infrared (NIR), photoacoustic (PA) and computed tomography (μCT) imaging. The diverse functionality of the composite was derived from the multi-channel imaging abilities and thermal competence on NIR laser irradiation to specifically actuate the photo-thermal ablation of brain cancer cells.
authors.affiliation: Bio-Nano Electronics Research Center, Toyo University, 2100, Kujirai, Kawagoe, Saitama, 350-8585, Japan. sakthi@toyo.jp.
authors.forename: M
authors.initials: M
authors.lastname: Sheikh Mohamed
authors.affiliation: Bio-Nano Electronics Research Center, Toyo University, 2100, Kujirai, Kawagoe, Saitama, 350-8585, Japan. sakthi@toyo.jp.
authors.forename: Aby Cheruvathoor
authors.initials: AC
authors.lastname: Poulose
authors.affiliation: Bio-Nano Electronics Research Center, Toyo University, 2100, Kujirai, Kawagoe, Saitama, 350-8585, Japan. sakthi@toyo.jp.
authors.forename: Srivani
authors.initials: S
authors.lastname: Veeranarayanan
authors.affiliation: Department of Material Science and NanoEngineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Romero Aburto
authors.affiliation: Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Trevor
authors.initials: T
authors.lastname: Mitcham
authors.affiliation: Biomedical Research Centre, Division of Analytical Science, Saitama Medical University, Saitama 350-0495, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Biomedical Research Centre, Division of Analytical Science, Saitama Medical University, Saitama 350-0495, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sakamoto
authors.affiliation: Department of Material Science and NanoEngineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.
authors.forename: Pulickel M
authors.initials: PM
authors.lastname: Ajayan
authors.affiliation: Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Bouchard
authors.affiliation: Bio-Nano Electronics Research Center, Toyo University, 2100, Kujirai, Kawagoe, Saitama, 350-8585, Japan. sakthi@toyo.jp.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: Bio-Nano Electronics Research Center, Toyo University, 2100, Kujirai, Kawagoe, Saitama, 350-8585, Japan. sakthi@toyo.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Maekawa
authors.affiliation: Bio-Nano Electronics Research Center, Toyo University, 2100, Kujirai, Kawagoe, Saitama, 350-8585, Japan. sakthi@toyo.jp.
authors.forename: D
authors.initials: D
authors.lastname: Sakthi Kumar
mesh_terms: D000818:Animals; D019187:Cadmium Compounds; D045744:Cell Line, Tumor; D003300:Copper; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D031286:Jatropha; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use* / Q000648:ultrastructure; D036103:Nanotechnology; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D019047:Phantoms, Imaging; D010789:Phototherapy / Q000379:methods*; D010938:Plant Oils; D045663:Quantum Dots / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D018036:Selenium Compounds; D017550:Spectroscopy, Fourier Transform Infrared; D013440:Sulfides; D055114:X-Ray Microtomography
chemical_list: D019187:Cadmium Compounds; D010938:Plant Oils; D018036:Selenium Compounds; D013440:Sulfides; D003300:Copper; C058667:cadmium selenide