title: Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin.
abstract: Metabolic reprogramming refers to the ability of cancer cells to alter their metabolism in order to support the increased energy request due to continuous growth, rapid proliferation, and other characteristics typical of neoplastic cells. It has long been believed that the increase of metabolic request was independent of the mitochondrial action but recently we know that mitochondrial activity together with metabolism plays a pivotal role in the regulation of the energy needed for tumor cell growth and proliferation. For these reasons the mitochondria pathways could be a new target for therapeutic and chemopreventive intervention. Metformin in particular is actually considered a promising agent against mitochondrial activity thanks to its ability to inhibit the mitochondrial complex I.
authors.affiliation: Division of Cancer Prevention and Genetics, European Institute of Oncology, 20141 Milan, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Cazzaniga
authors.affiliation: Division of Cancer Prevention and Genetics, European Institute of Oncology, 20141 Milan, Italy.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Bonanni
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000517:prevention & control; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008687:Metformin / Q000627:therapeutic use*; D008928:Mitochondria / Q000378:metabolism*
chemical_list: D008687:Metformin