title: The coexistence of peripheral nerve sheath tumors and vitiligo: more than coincidence?
abstract: Neurocristopathies arise from abnormal migration, differentiation, or proliferation of neural crest derivatives, leading to diverse clinical and pathological features. They are classified into dysgenetic or neoplastic, and can affect single or multiple sites (simple versus complex). Examples include congenital melanocytic nevi, neuroblastoma, Hirshsprung's disease, Waardenburg's syndrome, neurofibromatosis (NF) 1 and multiple endocrine neoplasia (MEN) 2A and 2B. We report two cases of peripheral nerve sheath tumors associated with vitiligo and discuss the possible implicated embryologic, genetic and molecular mechanisms. To our knowledge, we also report the first case of de novo malignant peripheral nerve sheath tumor (MPNST) associated with vitiligo.
authors.affiliation: Department of Neurosurgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Elsherif
authors.affiliation: Department of Neurosurgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Spinner.Robert@mayo.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Spinner
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Rachel Y
authors.initials: RY
authors.lastname: Miest
mesh_terms: D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000453:epidemiology / Q000209:etiology*; D014820:Vitiligo / Q000453:epidemiology / Q000209:etiology*
keywords: Malignant peripheral nerve sheath tumors; Neurocristopathies; Peripheral nerve sheath tumors; Schwannoma; Vitiligo