title: ε-Viniferin, a resveratrol dimer, prevents diet-induced obesity in mice.
abstract: Red wines are thought to be one of the major dietary sources of trans-resveratrol. The beneficial effects of t-resveratrol against metabolic disorders have been well characterized, however, red wines also contain various resveratrol derivatives whose health benefits have not been completely elucidated. In this report, we investigated ε-viniferin, a resveratrol dimer, which is present at comparable concentrations to t-resveratrol in red wines, and has higher anti-adipogenesis activity in 3T3-L1 cells. In addition, ε-viniferin was more effective than t-resveratrol in its anti-obesity and anti-inflammatory effects in high-fat diet fed mice. These results suggested ε-viniferin may be one of the active ingredients against metabolic disorders in red wines, in addition to t-resveratrol.
authors.affiliation: Kirin Company, Limited, Research Laboratories for Health Science and Food Technologies, Research and Development Division, 1-13-5, Fukuura Kanazawa-ku, Yokohama 236-0004, Japan. Electronic address: Kazuaki_Ohara@kirin.co.jp.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ohara
authors.affiliation: Kirin Company, Limited, Research Laboratories for Health Science and Food Technologies, Research and Development Division, 1-13-5, Fukuura Kanazawa-ku, Yokohama 236-0004, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Kusano
authors.affiliation: Kirin Company, Limited, Research Laboratories for Health Science and Food Technologies, Research and Development Division, 1-13-5, Fukuura Kanazawa-ku, Yokohama 236-0004, Japan.
authors.forename: Sayoko
authors.initials: S
authors.lastname: Kitao
authors.affiliation: Mercian Corporation, New Product & Process Developments, 4-9-1 Johnan, Fujisawa, Kanagawa 251-0057, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Yanai
authors.affiliation: Mercian Corporation, New Product & Process Developments, 4-9-1 Johnan, Fujisawa, Kanagawa 251-0057, Japan.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Takata
authors.affiliation: Kirin Company, Limited, Research Laboratories for Health Science and Food Technologies, Research and Development Division, 1-13-5, Fukuura Kanazawa-ku, Yokohama 236-0004, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Kanauchi
mesh_terms: D016475:3T3 Cells; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage; D001572:Benzofurans / Q000008:administration & dosage* / Q000737:chemistry; D059305:Diet, High-Fat / Q000009:adverse effects*; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D019440:Anti-Obesity Agents; D001572:Benzofurans; D013267:Stilbenes; C091891:epsilon-viniferin; D000077185:Resveratrol
keywords: Grape shoot extract; Obesity; Resveratrol; ε-Viniferin