title: Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
abstract: A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10(-10)) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.
authors.affiliation: The Generation R Study Group, Department of Pediatrics, Department of Epidemiology, j.felix@erasmusmc.nl.
authors.forename: Janine F
authors.initials: JF
authors.lastname: Felix
authors.affiliation: Center for Applied Genomics.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Bradfield
authors.affiliation: The Generation R Study Group, Department of Pediatrics, Department of Epidemiology.
authors.forename: Claire
authors.initials: C
authors.lastname: Monnereau
authors.affiliation: Department of Pulmonology, GRIAC (Groningen Research Institute for Asthma and COPD).
authors.forename: Ralf J P
authors.initials: RJ
authors.lastname: van der Valk
authors.affiliation: MRC Integrative Epidemiology Unit at the University of Bristol.
authors.forename: Evie
authors.initials: E
authors.lastname: Stergiakouli
authors.affiliation: Division of Human Genetics.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Chesi
authors.affiliation: The Generation R Study Group, Department of Pediatrics, Department of Epidemiology.
authors.forename: Romy
authors.initials: R
authors.lastname: Gaillard
authors.affiliation: Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Bjarke
authors.initials: B
authors.lastname: Feenstra
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany, Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Thiering
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
authors.forename: Eskil
authors.initials: E
authors.lastname: Kreiner-Møller
authors.affiliation: Wellcome Trust Centre for Human Genetics.
authors.forename: Anubha
authors.initials: A
authors.lastname: Mahajan
authors.affiliation: Research Centre of Applied and Preventive Cardiovascular Medicine, Institute of Clinical Medicine, Neurology.
authors.forename: Niina
authors.initials: N
authors.lastname: Pitkänen
authors.affiliation: Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Raimo
authors.initials: R
authors.lastname: Joro
authors.affiliation: Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK, Population, Policy and Practice, UCL Institute of Child Health.
authors.forename: Alana
authors.initials: A
authors.lastname: Cavadino
authors.affiliation: Centre for Life Course Epidemiology.
authors.forename: Ville
authors.initials: V
authors.lastname: Huikari
authors.affiliation: Institute of Reproductive and Developmental Biology.
authors.forename: Steve
authors.initials: S
authors.lastname: Franks
authors.affiliation: Department of Biological Psychology, VU University Amsterdam, NCA Neuroscience Campus Amsterdam, EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Groen-Blokhuis
authors.affiliation: Institute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland.
authors.forename: Diana L
authors.initials: DL
authors.lastname: Cousminer
authors.affiliation: School of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Marsh
authors.affiliation: Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, Department of Clinical Chemistry.
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.affiliation: Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.
authors.forename: John A
authors.initials: JA
authors.lastname: Curtin
authors.affiliation: Universidad Miguel Hernandez, Elche-Alicante, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Vioque
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Steno Diabetes Center, Gentofte, Denmark.
authors.forename: Tarunveer S
authors.initials: TS
authors.lastname: Ahluwalia
authors.affiliation: Department of Genes and Envrionment, Division of Epidemiology.
authors.forename: Ronny
authors.initials: R
authors.lastname: Myhre
authors.affiliation: Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, USA.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Price
authors.affiliation: CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Pompeu Fabra University (UPF), Barcelona, Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Vilor-Tejedor
authors.affiliation: CNRS UMR8199, Pasteur Institute Lille, France, European Genomic Institute for Diabetes (EGID), Lille, France.
authors.forename: Loïc
authors.initials: L
authors.lastname: Yengo
authors.affiliation: Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Niels
authors.initials: N
authors.lastname: Grarup
authors.affiliation: Department of Health Sciences, University of Leicester, Leicester, UK, Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Ntalla
authors.affiliation: School of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
authors.forename: Wei
authors.initials: W
authors.lastname: Ang
authors.affiliation: Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Atalay
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
authors.forename: Hans
authors.initials: H
authors.lastname: Bisgaard
authors.affiliation: Section of Investigative Medicine, Division of Diabetes, Endocrinology, and Metabolism, Faculty of Medicine, Imperial College, London, UK.
authors.forename: Alexandra I
authors.initials: AI
authors.lastname: Blakemore
authors.affiliation: CNRS UMR8199, Pasteur Institute Lille, France, European Genomic Institute for Diabetes (EGID), Lille, France.
authors.forename: Amelie
authors.initials: A
authors.lastname: Bonnefond
authors.affiliation: Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Carstensen
authors.affiliation: National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Johan
authors.initials: J
authors.lastname: Eriksson
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Flexeder
authors.affiliation: Department of Genetics.
authors.forename: Lude
authors.initials: L
authors.lastname: Franke
authors.affiliation: Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Frank
authors.initials: F
authors.lastname: Geller
authors.affiliation: Center of Pediatric Research, Department of Women's and Child Health, LIFE Child (Leipzig Research Center for Civilization Diseases).
authors.forename: Mandy
authors.initials: M
authors.lastname: Geserick
authors.affiliation: Institute of Clinical Medicine/Obstetrics and Gynecology.
authors.forename: Anna-Liisa
authors.initials: AL
authors.lastname: Hartikainen
authors.affiliation: Department of Psychology, University of Warwick, UK.
authors.forename: Claire M A
authors.initials: CM
authors.lastname: Haworth
authors.affiliation: Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, USA, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, USA, Department of Genetics, Harvard Medical School, Boston, USA.
authors.forename: Joel N
authors.initials: JN
authors.lastname: Hirschhorn
authors.affiliation: The Generation R Study Group, Department of Epidemiology.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, The Danish Childhood Obesity Biobank, Denmark, Institute of Medicine, Copenhagen University, Copenhagen, Denmark.
authors.forename: Jens-Christian
authors.initials: JC
authors.lastname: Holm
authors.affiliation: Wellcome Trust Centre for Human Genetics, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
authors.forename: Momoko
authors.initials: M
authors.lastname: Horikoshi
authors.affiliation: Department of Biological Psychology, VU University Amsterdam, NCA Neuroscience Campus Amsterdam, EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
authors.forename: Jouke Jan
authors.initials: JJ
authors.lastname: Hottenga
authors.affiliation: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jinyan
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark.
authors.forename: Haja N
authors.initials: HN
authors.lastname: Kadarmideen
authors.affiliation: Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland, Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.affiliation: Center of Pediatric Research, Department of Women's and Child Health.
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
authors.affiliation: Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Hanna-Maaria
authors.initials: HM
authors.lastname: Lakka
authors.affiliation: Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland, Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Timo A
authors.initials: TA
authors.lastname: Lakka
authors.affiliation: Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London, UK.
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Lewin
authors.affiliation: Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Boston, USA.
authors.forename: Liming
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland, Department of Clinical Chemistry.
authors.forename: Leo-Pekka
authors.initials: LP
authors.lastname: Lyytikäinen
authors.affiliation: College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning Province, China.
authors.forename: Baoshan
authors.initials: B
authors.lastname: Ma
authors.affiliation: Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
authors.forename: Per
authors.initials: P
authors.lastname: Magnus
authors.affiliation: Division of Human Genetics, Division of Endocrinology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Shana E
authors.initials: SE
authors.lastname: McCormack
authors.affiliation: MRC Integrative Epidemiology Unit at the University of Bristol.
authors.forename: George
authors.initials: G
authors.lastname: McMahon
authors.affiliation: Center for Applied Genomics.
authors.forename: Frank D
authors.initials: FD
authors.lastname: Mentch
authors.affiliation: Department of Biological Psychology, VU University Amsterdam, NCA Neuroscience Campus Amsterdam, EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
authors.forename: Christel M
authors.initials: CM
authors.lastname: Middeldorp
authors.affiliation: Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.
authors.forename: Clare S
authors.initials: CS
authors.lastname: Murray
authors.affiliation: Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Health and Physical Activity, Paavo Nurmi Centre, Sports and Exercise Medicine Unit.
authors.forename: Katja
authors.initials: K
authors.lastname: Pahkala
authors.affiliation: Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, USA, Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, USA.
authors.forename: Tune H
authors.initials: TH
authors.lastname: Pers
authors.affiliation: Center of Pediatric Research, Department of Women's and Child Health, CrescNet, Medical Faculty, University of Leipzig, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Pfäffle
authors.affiliation: Department of Pulmonology, GRIAC (Groningen Research Institute for Asthma and COPD).
authors.forename: Dirkje S
authors.initials: DS
authors.lastname: Postma
authors.affiliation: Population, Policy and Practice, UCL Institute of Child Health.
authors.forename: Christine
authors.initials: C
authors.lastname: Power
authors.affiliation: Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and.
authors.forename: Angela
authors.initials: A
authors.lastname: Simpson
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahlgrenska University Hosptial, Gothenburg, Sweden.
authors.forename: Verena
authors.initials: V
authors.lastname: Sengpiel
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany, Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
authors.forename: Carla M T
authors.initials: CM
authors.lastname: Tiesler
authors.affiliation: CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Area de Salut de Menorca, ib-salut, Menorca, Spain.
authors.forename: Maties
authors.initials: M
authors.lastname: Torrent
authors.affiliation: The Generation R Study Group, Department of Epidemiology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.affiliation: Department of Epidemiology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Joyce B
authors.initials: JB
authors.lastname: van Meurs
authors.affiliation: Department of Pediatrics, Naestved Hospital, Naestved, Denmark, COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Vinding
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
authors.forename: Johannes
authors.initials: J
authors.lastname: Waage
authors.affiliation: Department of Epidemiology and Public Health, University College London, UK.
authors.forename: Jane
authors.initials: J
authors.lastname: Wardle
authors.affiliation: Wellcome Trust Sanger Institute, The Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Zeggini
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Babette S
authors.initials: BS
authors.lastname: Zemel
authors.affiliation: Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
authors.forename: George V
authors.initials: GV
authors.lastname: Dedoussis
authors.affiliation: Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Oluf
authors.initials: O
authors.lastname: Pedersen
authors.affiliation: CNRS UMR8199, Pasteur Institute Lille, France, Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
authors.affiliation: CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Pompeu Fabra University (UPF), Barcelona, Spain, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Sunyer
authors.affiliation: King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Plomin
authors.affiliation: Department of Genes and Envrionment, Division of Epidemiology, Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahlgrenska University Hosptial, Gothenburg, Sweden.
authors.forename: Bo
authors.initials: B
authors.lastname: Jacobsson
authors.affiliation: Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Hansen
authors.affiliation: CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Pompeu Fabra University (UPF), Barcelona, Spain.
authors.forename: Juan R
authors.initials: JR
authors.lastname: Gonzalez
authors.affiliation: Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.
authors.forename: Adnan
authors.initials: A
authors.lastname: Custovic
authors.affiliation: Research Centre of Applied and Preventive Cardiovascular Medicine, Department of Clinical Physiology and Nuclear Medicine.
authors.forename: Olli T
authors.initials: OT
authors.lastname: Raitakari
authors.affiliation: School of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
authors.forename: Craig E
authors.initials: CE
authors.lastname: Pennell
authors.affiliation: Institute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Widén
authors.affiliation: Department of Biological Psychology, VU University Amsterdam, NCA Neuroscience Campus Amsterdam, EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
authors.affiliation: Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Gerard H
authors.initials: GH
authors.lastname: Koppelman
authors.affiliation: Centre for Life Course Epidemiology, Biocenter Oulu, University of Oulu, Oulu, Finland.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Sebert
authors.affiliation: Centre for Life Course Epidemiology, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London, UK, Unit of Primary Care, Oulu University Hospital, Oulu, Finland, Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.
authors.forename: Marjo-Riitta
authors.initials: MR
authors.lastname: Järvelin
authors.affiliation: Population, Policy and Practice, UCL Institute of Child Health, School of Population Health and Sansom Institute, University of South Australia, Adelaide, Australia, South Australian Health and Medical Research Institute, Adelaide, Australia.
authors.forename: Elina
authors.initials: E
authors.lastname: Hyppönen
authors.affiliation: Wellcome Trust Centre for Human Genetics, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK, Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital, Oxford, UK.
authors.forename: Mark I
authors.initials: MI
authors.lastname: McCarthy
authors.affiliation: Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Virpi
authors.initials: V
authors.lastname: Lindi
authors.affiliation: Department of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland.
authors.forename: Niinikoski
authors.initials: N
authors.lastname: Harri
authors.affiliation: Center of Pediatric Research, Department of Women's and Child Health.
authors.forename: Antje
authors.initials: A
authors.lastname: Körner
authors.affiliation: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital.
authors.forename: Klaus
authors.initials: K
authors.lastname: Bønnelykke
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
authors.affiliation: Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA and.
authors.forename: Mads
authors.initials: M
authors.lastname: Melbye
authors.affiliation: The Generation R Study Group, Department of Epidemiology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivadeneira
authors.affiliation: Center for Applied Genomics, Division of Human Genetics, Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahlgrenska University Hosptial, Gothenburg, Sweden.
authors.forename: Hakon
authors.initials: H
authors.lastname: Hakonarson
authors.affiliation: MRC Integrative Epidemiology Unit at the University of Bristol, Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Ring
authors.affiliation: MRC Integrative Epidemiology Unit at the University of Bristol.
authors.forename: George Davey
authors.initials: GD
authors.lastname: Smith
authors.affiliation: MRC Integrative Epidemiology Unit at the University of Bristol, Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
authors.forename: Thorkild I A
authors.initials: TI
authors.lastname: Sørensen
authors.affiliation: MRC Integrative Epidemiology Unit at the University of Bristol.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Timpson
authors.affiliation: Center for Applied Genomics, Division of Human Genetics, Division of Endocrinology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Struan F A
authors.initials: SF
authors.lastname: Grant
authors.affiliation: The Generation R Study Group, Department of Pediatrics, Department of Epidemiology.
authors.forename: Vincent W V
authors.initials: VW
authors.lastname: Jaddoe
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D005260:Female; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People / Q000235:genetics; D055815:Young Adult