title: Feasibility of an Intraluminal Bypass Device in Low Colorectal Anastomosis: Preliminary Results in a Porcine Model.
abstract: BACKGROUND
  The Cologuard CG-100 is a novel intraluminal bypass device designed to reduce the clinical outcomes associated with low colorectal anastomotic leak. The device is inserted transanally, anchored to the colon above the anastomosis, and deployed intraluminally to cover the anastomosis from within. The purpose of this study was to evaluate the safety and performance of the device in a porcine model.
  
  
  METHODS
  Twelve pigs underwent low colorectal anastomosis with insertion of the Cologuard CG-100 device. Contrast material injection, abdominal X-ray, and histologic studies were used to evaluate sealing quality, device positioning, and tissue damage, respectively. The surgeons completed a usability and satisfaction questionnaire after completion of the procedure.
  
  
  RESULTS
  Absolute sealing was observed in all 4 animals euthanized immediately after surgery. In the other 8 animals, the device was kept in situ for 10 days and then extracted. X-ray films with injection of contrast material through a designated injection tube before device removal showed that the sheath and ring were correctly placed. No leak was demonstrated. There were no device-related adverse events, and no critical histological abnormalities were noted in the bowel area that was compressed by the device. The device was found to be easy to insert, position, and extract.
  
  
  CONCLUSIONS
  The Cologuard CG-100 device efficiently reduced contact between fecal content and low colorectal anastomosis in a porcine model and is easily deployed and extracted. It holds promise for possible clinical use pending further studies.
authors.affiliation: The Institute of Animal Research, Kibbutz Lahav, Israel.
authors.forename: Udi
authors.initials: U
authors.lastname: Willenz
authors.affiliation: Rabin Medical Center, Petach Tikva, Israel Tel Aviv University, Tel Aviv, Israel nirw@clalit.co.il.
authors.forename: Nir
authors.initials: N
authors.lastname: Wasserberg
authors.affiliation: Pathovet, Rehovot, Israel.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Botero-Anug
authors.affiliation: Tel Aviv University, Tel Aviv, Israel Tel Aviv Medical Center, Tel Aviv, Israel.
authors.forename: Ron
authors.initials: R
authors.lastname: Greenberg
mesh_terms: D000714:Anastomosis, Surgical / Q000295:instrumentation / Q000379:methods; D057868:Anastomotic Leak / Q000517:prevention & control*; D017130:Angioplasty / Q000295:instrumentation*; D000818:Animals; D003107:Colorectal Surgery / Q000009:adverse effects / Q000379:methods; D004195:Disease Models, Animal; D005240:Feasibility Studies; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods*; D012007:Rectum / Q000601:surgery*; D013552:Swine; D016896:Treatment Outcome
keywords: anastomotic leak; colorectal surgery; intraluminal device