title: Antidepressants and Gastric Cancer: A Nationwide Population-Based Nested Case-Control Study.
abstract: BACKGROUND
  To our knowledge, no epidemiological study has reported on whether an association between antidepressant exposure and gastric cancer exists. Herein, we aim to investigate the possible association between antidepressant exposure and gastric cancer incidence.
  
  
  METHODS
  Using a nested case-control design, we identified 26289 cases with gastric cancer and 127984 controls from Taiwan's National Health Insurance Research Database (NHIRD). The data were analyzed using a conditional logistic regression model adjusting for possible confounding variables.
  
  
  RESULTS
  We found antidepressant use did not increase the risk of gastric cancer. The lack of an association between antidepressant prescription and elevated gastric cancer incidence was apparent for across selective serotonin-reuptake inhibitors (SSRIs), tricyclic agents (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), reversible inhibitors of monoamine oxidase A (RIMA), trazodone, mirtazapine and bupropion. There were slightly decreased gastric cancer risks of SSRIs use (≧28 DDD group, adjusted OR = 0.87; 95% CI = 0.78-0.96). Sensitive analysis showed SSRIs, TCAs, and SNRIs did not increase gastric cancer risks significantly even in the group with peptic ulcer history.
  
  
  CONCLUSIONS
  An association between antidepressant exposure and gastric cancer was not apparent in this analysis.
authors.affiliation: Department of Child and Adolescent Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Yi-Hsuan
authors.initials: YH
authors.lastname: Hsieh
authors.affiliation: Department of Psychiatry, Cathay General Hospital, Taipei 10630, Taiwan.|School of Medicine, Fu Jen Catholic University, Taipei 24205, Taiwan.
authors.forename: Wei-Che
authors.initials: WC
authors.lastname: Chiu
authors.affiliation: Department of Child and Adolescent Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Chiao-Fan
authors.initials: CF
authors.lastname: Lin
authors.affiliation: Department of Child and Adolescent Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Hsiang-Lin
authors.initials: HL
authors.lastname: Chan
authors.affiliation: Department of Child and Adolescent Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Liang
authors.affiliation: School of Medicine, Fu Jen Catholic University, Taipei 24205, Taiwan.
authors.forename: Yena
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, University of Toronto, Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.
authors.forename: Roger S
authors.initials: RS
authors.lastname: McIntyre
authors.affiliation: Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
authors.forename: Vincent Chin-Hung
authors.initials: VC
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D015897:Comorbidity; D015986:Confounding Factors, Epidemiologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D012306:Risk; D012959:Socioeconomic Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents