title: A strategy for enhanced antibacterial activity against Staphylococcus aureus by the assembly of alamethicin with a thermo-sensitive polymeric carrier.
abstract: We demonstrate here a strategy for enhanced antibacterial activity against microbial strains by the assembly of antimicrobial peptides with a temperature-responsive polymeric carrier. The assembly complex was less toxic to human cells and more stable to enzymatic cleavage. This work may provide a promising drug delivery system for antimicrobial peptides.
authors.affiliation: School for Radiological and Interdisciplinary Sciences (RAD-X) & College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. dbhua_lab@suda.edu.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Dong
authors.affiliation: School for Radiological and Interdisciplinary Sciences (RAD-X) & College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. dbhua_lab@suda.edu.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: School for Radiological and Interdisciplinary Sciences (RAD-X) & College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. dbhua_lab@suda.edu.cn and Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: He
authors.affiliation: School for Radiological and Interdisciplinary Sciences (RAD-X) & College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. dbhua_lab@suda.edu.cn and Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China.
authors.forename: Daoben
authors.initials: D
authors.lastname: Hua