title: Phthalate monoesters in association with uterine leiomyomata in Shanghai.
abstract: Phthalates are ubiquitous environmental pollutants because of the broad use of plastics. We conducted a case-control study to determine whether uterine leiomyomata were related to exposure to phthalates. Urine specimens and questionnaires were collected from 61 cases and 61 age-matched controls. Nine phthalate monoesters were determined by ultra performance liquid chromatography coupled with tandem mass spectroscopy. Cases had significantly higher levels of creatinine-adjusted mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-oxohexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), total di(2-ethylhexyl) phthalate metabolites (∑DEHPmet), and total dibutyl phthalate metabolites (∑DBP(met)) than controls. After adjusting for potential confounders, logistic regression analyses demonstrated that leiomyomata were positively associated with MiBP, MnBP, MEHP, MEHHP, MECPP, ∑DEHP(met), and ∑DBP(met). In summary, our data support the hypothesis that uterine leiomyomata are related to phthalate exposure.
authors.affiliation: a Department of Gynecology , Shanghai First Maternity and Infant Hospital of Tongji University , Shanghai , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: b Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Mei-Ru
authors.initials: MR
authors.lastname: Zhang
authors.affiliation: b Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Li-Qian
authors.initials: LQ
authors.lastname: Zhang
authors.affiliation: a Department of Gynecology , Shanghai First Maternity and Infant Hospital of Tongji University , Shanghai , China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhao
authors.affiliation: b Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Li
authors.affiliation: b Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, School of Public Health , Fudan University , Shanghai , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004781:Environmental Exposure; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000652:urine*; D004952:Esters / Q000652:urine*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000139:chemically induced / Q000453:epidemiology*; D010795:Phthalic Acids / Q000652:urine*; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D004952:Esters; D010795:Phthalic Acids
keywords: di-(2-ethylhexyl)-phthalate (DEHP); dibutyl phthalate; phthalate exposure; phthalate monoesters; uterine leiomyomata