title: Models for Predicting Drug Absorption From Oral Lipid-Based Formulations.
abstract: In this review, we describe the in vitro tools currently used to identify when a lipid-based formulation has the potential to deliver a poorly water-soluble drug via the oral route. We describe the extent to which these tools reflect the in vivo performance of the formulation and, more importantly, we present strategies that we foresee will improve the in vitro-in vivo correlations. We also present emerging computational methods that are likely to allow large parts of the formulation development to be carried out in the computer rather than in the test tube. We suggest that these computational tools will also improve the mechanistic understanding of in vivo formulation performance in the complex and dynamic environment of the gut.
authors.affiliation: Department of Pharmacy, Uppsala University, Uppsala Biomedical Center, P.O Box 580, SE-751 23 Uppsala, Sweden.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Alskär
authors.affiliation: Department of Pharmacy, Uppsala University, Uppsala Biomedical Center, P.O Box 580, SE-751 23 Uppsala, Sweden.
authors.forename: Christel A S
authors.initials: CA
authors.lastname: Bergström
keywords: Formulation performance; In vitro models; Lipid-based formulations; Molecular dynamics simulations; Multivariate data analysis; Prediction