title: Genetics of Sleep Disorders.
abstract: Sleep disorders are, in part, attributable to genetic variability across individuals. There has been considerable progress in understanding the role of genes for some sleep disorders, such as the identification of a human leukocyte antigen gene for narcolepsy. For other sleep disorders, such as insomnia, little work has been done. Optimizing phenotyping strategies is critical, as is the case for sleep apnea, for which intermediate traits such as obesity and craniofacial features may prove to be more tractable for genetic studies. Rapid advances in genotyping and statistical genetics are likely to lead to greater discoveries in the near future.
authors.affiliation: Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA. Electronic address: gehrman@exchange.upenn.edu.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Gehrman
authors.affiliation: Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Suite 2100, Philadelphia, PA 19104-3403, USA.
authors.forename: Brendan T
authors.initials: BT
authors.lastname: Keenan
authors.affiliation: Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Suite 2100, Philadelphia, PA 19104-3403, USA; Queensland Brain Institute, Brisbane QLD 4072, Australia.
authors.forename: Enda M
authors.initials: EM
authors.lastname: Byrne
authors.affiliation: Division of Sleep Medicine, Department of Medicine, Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Suite 2100, Philadelphia, PA 19104-3403, USA.
authors.forename: Allan I
authors.initials: AI
authors.lastname: Pack
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009290:Narcolepsy / Q000235:genetics*; D012148:Restless Legs Syndrome / Q000235:genetics*; D012891:Sleep Apnea Syndromes / Q000235:genetics*; D020178:Sleep Disorders, Circadian Rhythm / Q000235:genetics*; D007319:Sleep Initiation and Maintenance Disorders / Q000235:genetics*
keywords: Genetics; Insomnia; Narcolepsy; Restless legs syndrome; Sleep apnea; Sleep disorder