title: 3D Biomaterial Microarrays for Regenerative Medicine: Current State-of-the-Art, Emerging Directions and Future Trends.
abstract: Three dimensional (3D) biomaterial microarrays hold enormous promise for regenerative medicine because of their ability to accelerate the design and fabrication of biomimetic materials. Such tissue-like biomaterials can provide an appropriate microenvironment for stimulating and controlling stem cell differentiation into tissue-specific lineages. The use of 3D biomaterial microarrays can, if optimized correctly, result in a more than 1000-fold reduction in biomaterials and cells consumption when engineering optimal materials combinations, which makes these miniaturized systems very attractive for tissue engineering and drug screening applications.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.|Department of Materials Science and Engineering, Texas A&M University, College Station, TX, 77843, USA.
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Gaharwar
authors.affiliation: Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
authors.forename: Ayyoob
authors.initials: A
authors.lastname: Arpanaei
authors.affiliation: Technical University of Denmark, DTU Nanotech, Center for Nanomedicine and Theranostics, 2800, Kgs, Denmark.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Andresen
authors.affiliation: Technical University of Denmark, DTU Nanotech, Center for Nanomedicine and Theranostics, 2800, Kgs, Denmark.
authors.forename: Alireza
authors.initials: A
authors.lastname: Dolatshahi-Pirouz
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D002470:Cell Survival; D053595:Embryonic Stem Cells / Q000166:cytology; D016326:Extracellular Matrix Proteins / Q000737:chemistry; D057166:High-Throughput Screening Assays; D006801:Humans; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods*; D044968:Regenerative Medicine; D054852:Small Molecule Libraries / Q000737:chemistry / Q000633:toxicity; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D016326:Extracellular Matrix Proteins; D054852:Small Molecule Libraries
keywords: 3D microarrays; 3D printing; biomaterials; microfabrication; tissue engineering