title: A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development.
abstract: Multiple plant developmental processes, such as lateral root development, depend on auxin distribution patterns that are in part generated by the PIN-formed family of auxin-efflux transporters. Here we propose that AUXIN RESPONSE FACTOR7 (ARF7) and the ARF7-regulated FOUR LIPS/MYB124 (FLP) transcription factors jointly form a coherent feed-forward motif that mediates the auxin-responsive PIN3 transcription in planta to steer the early steps of lateral root formation. This regulatory mechanism might endow the PIN3 circuitry with a temporal 'memory' of auxin stimuli, potentially maintaining and enhancing the robustness of the auxin flux directionality during lateral root development. The cooperative action between canonical auxin signalling and other transcription factors might constitute a general mechanism by which transcriptional auxin-sensitivity can be regulated at a tissue-specific level.
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.|State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.|Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: Maere
authors.affiliation: Department of Botany, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
authors.forename: Eunkyoung
authors.initials: E
authors.lastname: Lee
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.
authors.forename: Gert
authors.initials: G
authors.lastname: Van Isterdael
authors.affiliation: Center for Applied Plant Sciences (CAPS) and Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Zidian
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.
authors.forename: Wei
authors.initials: W
authors.lastname: Xuan
authors.affiliation: Department of Botany, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
authors.forename: Jessica
authors.initials: J
authors.lastname: Lucas
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.|Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Academik Georgi Bonchev Street, Sofia 1113, Bulgaria.
authors.forename: Valya
authors.initials: V
authors.lastname: Vassileva
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.|Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka 560-0043 Japan.
authors.forename: Saeko
authors.initials: S
authors.lastname: Kitakura
authors.affiliation: Institute of Science and Technology Austria, Klosterneuburg 3400, Austria.|Department of Plant Molecular Biology, UNIL-Sorge, University of Lausanne, Lausanne 1015, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Marhavý
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.|Institute of Science and Technology Austria, Klosterneuburg 3400, Austria.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Wabnik
authors.affiliation: Department of Plant Molecular Biology, UNIL-Sorge, University of Lausanne, Lausanne 1015, Switzerland.
authors.forename: Niko
authors.initials: N
authors.lastname: Geldner
authors.affiliation: Institute of Science and Technology Austria, Klosterneuburg 3400, Austria.
authors.forename: Eva
authors.initials: E
authors.lastname: Benková
authors.affiliation: Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Le
authors.affiliation: Department of Biology, Graduate School of Science, Kobe University, 1-1 Rokkodai, Kobe 657-8501, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Fukaki
authors.affiliation: Center for Applied Plant Sciences (CAPS) and Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Erich
authors.initials: E
authors.lastname: Grotewold
authors.affiliation: State Key Laboratory of Plant Genomics, National Centre for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Chuanyou
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.|Institute of Science and Technology Austria, Klosterneuburg 3400, Austria.
authors.forename: Jiří
authors.initials: J
authors.lastname: Friml
authors.affiliation: Department of Botany, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
authors.forename: Fred
authors.initials: F
authors.lastname: Sack
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Beeckman
authors.affiliation: Department of Plant Systems Biology, VIB, Ghent 9052, Belgium.|Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent 9052, Belgium.
authors.forename: Steffen
authors.initials: S
authors.lastname: Vanneste
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000254:growth & development; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D047369:Chromatin Immunoprecipitation; D025461:Feedback, Physiological; D018506:Gene Expression Regulation, Plant; D005966:Glucuronidase / Q000378:metabolism; D030781:Organisms, Genetically Modified; D018517:Plant Roots / Q000254:growth & development* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: C503425:ARF7 protein, Arabidopsis; D029681:Arabidopsis Proteins; C507998:FLP protein, Arabidopsis; C449300:PIN3 protein, Arabidopsis; D012333:RNA, Messenger; D014157:Transcription Factors; D005966:Glucuronidase