title: Metabolic differentiation and classification of abnormal Savda Munziq's pharmacodynamic role on rat models with different diseases by nuclear magnetic resonance-based metabonomics.
abstract: BACKGROUND
  Abnormal Savda Munziq (ASMq) is a traditional Uyghur herbal preparation used as a therapy for abnormal Savda-related diseases. In this study, we investigate ASMq's dynamic effects on abnormal Savda rat models under different disease conditions.
  
  
  METHODS
  Abnormal Savda rat models with hepatocellular carcinoma (HCC), type 2 diabetes mellitus (T2DM), and asthma dosed of ASMq. Serum samples of each animal tested by nuclear magnetic resonance spectroscopy and analyzed by orthogonal projection to latent structure with discriminant analysis.
  
  
  RESULTS
  Compared with healthy controls, HCC rats had higher concentrations of amino acids, fat-related metabolites, lactate, myoinositol, and citrate, but lower concentrations of α-glucose, β-glucose, and glutamine. Following ASMq treatment, the serum acetone very low-density lipoprotein (VLDL), LDL, unsaturated lipids, acetylcysteine, and pyruvate concentration decreased, but α-glucose, β-glucose, and glutamine concentration increased (P < 0.05). T2DM rats had higher concentrations of α- and β-glucose, but lower concentrations of isoleucine, leucine, valine, glutamine, glycoprotein, lactate, tyrosine, creatine, alanine, carnitine, and phenylalanine. After ASMq treated T2DM groups showed reduced α- and β-glucose and increased creatine levels (P < 0.05). Asthma rats had higher acetate, carnitine, formate, and phenylalanine levels, but lower concentrations of glutamine, glycoprotein, lactate, VLDL, LDL, and unsaturated lipids. ASMq treatment showed increased glutamine and reduced carnitine, glycoprotein, formate, and phenylalanine levels (P < 0.05).
  
  
  CONCLUSIONS
  Low immune function, decreased oxidative defense, liver function abnormalities, amino acid deficiencies, and energy metabolism disorders are common characteristics of abnormal Savda-related diseases. ASMq may improve the abnormal metabolism and immune function of rat models with different diseases combined abnormal Savda.
authors.affiliation: Central Laboratory, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Batur
authors.initials: B
authors.lastname: Mamtimin
authors.affiliation: Central Laboratory, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Xia
authors.affiliation: College of Basic Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Mijit
authors.affiliation: College of Traditional Uyghur Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Mawlanjan
authors.initials: M
authors.lastname: Hizbulla
authors.affiliation: Central Laboratory, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Nazuk
authors.initials: N
authors.lastname: Kurbantay
authors.affiliation: College of Traditional Uyghur Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Li
authors.initials: L
authors.lastname: You
authors.affiliation: College of Traditional Uyghur Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Halmurat
authors.initials: H
authors.lastname: Upur
keywords: Abnormal Savda; abnormal Savda Munziq; metabonomics; rat model; traditional Uyghur medicine