title: Effect of exercise on fluoride metabolism in adult humans: a pilot study.
abstract: An understanding of all aspects of fluoride metabolism is critical to identify its biological effects and avoid fluoride toxicity in humans. Fluoride metabolism and subsequently its body retention may be affected by physiological responses to acute exercise. This pilot study investigated the effect of exercise on plasma fluoride concentration, urinary fluoride excretion and fluoride renal clearance following no exercise and three exercise intensity conditions in nine healthy adults after taking a 1-mg Fluoride tablet. After no, light, moderate and vigorous exercise, respectively, the mean (SD) baseline-adjusted i) plasma fluoride concentration was 9.6(6.3), 11.4(6.3), 15.6(7.7) and 14.9(10.0) ng/ml; ii) rate of urinary fluoride excretion over 0-8 h was 46(15), 44(22), 34(17) and 36(17) μg/h; and iii) rate of fluoride renal clearance was 26.5(9.0), 27.2(30.4), 13.1(20.4) and 18.3(34.9) ml/min. The observed trend of a rise in plasma fluoride concentration and decline in rate of fluoride renal clearance with increasing exercise intensity needs to be investigated in a larger trial. This study, which provides the first data on the effect of exercise with different intensities on fluoride metabolism in humans, informs sample size planning for any subsequent definitive trial, by providing a robust estimate of the variability of the effect.
authors.affiliation: Health and Social Care Institute, Teesside University, Middlesbrough, UK.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: V Zohoori
authors.affiliation: School of Social Sciences, Business &Law, Teesside University, Middlesbrough, UK.
authors.forename: Alison
authors.initials: A
authors.lastname: Innerd
authors.affiliation: Health and Social Care Institute, Teesside University, Middlesbrough, UK.
authors.forename: Liane B
authors.initials: LB
authors.lastname: Azevedo
authors.affiliation: Department of Oral Biology, College of Dental Medicine, Georgia Regents University, Augusta, US.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Whitford
authors.affiliation: Centre for Oral Health Research, School of Dental Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Maguire
mesh_terms: D000328:Adult; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D015444:Exercise / Q000502:physiology*; D005260:Female; D005459:Fluorides / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008297:Male; D010865:Pilot Projects; D055815:Young Adult
chemical_list: D005459:Fluorides