title: Dietary conjugated linoleic acids increase intramuscular fat deposition and decrease subcutaneous fat deposition in Yellow Breed × Simmental cattle.
abstract: This study was conducted to estimate the effect of dietary conjugated linoleic acids (CLA) on intramuscular and subcutaneous fat deposition in Yellow Breed × Simmental cattle. The experiment was conducted for 60 days. The results showed that the average backfat thickness, (testicles + kidney + pelvic) fat percentage and subcutaneous fat percentage in dietary CLA were significantly lower than in the control group, while intramuscular the fat percentage was significantly higher. Compared to the control group, the Longissimus muscle enzyme activities of lipoprotein lipase (LPL), fatty acid synthase (FAS) and acetyl-coenzyme A carboxylase (ACC) in dietary CLA and the subcutaneous fat enzyme activities of LPL, hormone-sensitive lipase (HSL) and carnitine palmitoyltransferase-1 (CPT-1) were significantly increased. Similarly, compared to the control group, the Longissimus muscle sterol regulatory element binding protein 1 (SREBP-1), FAS, stearoyl-coenzyme A desaturase (SCD), ACC, peroxisome proliferator-activated receptor γ (PPARγ), heart fatty-acid binding protein (H-FABP) and LPL gene expression in dietary CLA were significant increased, as were the subcutaneous fat of PPARγ, H-FABP, LPL, CPT-1 and HSL in dietary CLA. These results indicated that dietary CLA increases IMF deposition mainly by the up-regulation of lipogenic gene expression, while decreasing subcutaneous fat deposition mainly by the up-regulation of lipolytic gene expression.
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, China.|Sichuan Academy of Grassland Science, Chengdu, Sichuan, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, China.
authors.forename: Xianwen
authors.initials: X
authors.lastname: Dong
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, China.
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, China.
authors.forename: Aiming
authors.initials: A
authors.lastname: Zhou
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, China.
authors.forename: Quanhui
authors.initials: Q
authors.lastname: Peng
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Zou
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, China.
authors.forename: Bai
authors.initials: B
authors.lastname: Xue
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute of Sichuan Agricultural University, Ya'an, China.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Wang
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002334:Carnitine O-Palmitoyltransferase / Q000235:genetics / Q000378:metabolism; D002417:Cattle / Q000235:genetics* / Q000378:metabolism*; D004032:Diet / Q000662:veterinary*; D005223:Fats / Q000378:metabolism*; D054890:Fatty Acid Synthase, Type I / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D050155:Lipogenesis / Q000235:genetics*; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism*; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D013230:Stearoyl-CoA Desaturase / Q000235:genetics / Q000378:metabolism; D002787:Sterol Esterase / Q000235:genetics / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism; D050151:Subcutaneous Fat / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D005223:Fats; D044243:Linoleic Acids, Conjugated; D047495:PPAR gamma; D051780:Sterol Regulatory Element Binding Protein 1; D013230:Stearoyl-CoA Desaturase; D002334:Carnitine O-Palmitoyltransferase; D054890:Fatty Acid Synthase, Type I; D002787:Sterol Esterase; D008071:Lipoprotein Lipase; D000103:Acetyl-CoA Carboxylase
keywords: cattle; conjugated linoleic acids; intramuscular fat; subcutaneous fat