title: The relationships of irisin with bone mineral density and body composition in PCOS patients.
abstract: OBJECTIVE
  Our study aims to assay the irisin level and investigate the relationships of irisin level with body mass index (BMI), body composition and bone metabolism in the polycystic ovary syndrome (PCOS) and control women.
  
  
  METHODS
  Fifty two PCOS and 39 control women were recruited. Serum sex hormone, fasting insulin and C-peptide were tested. Fasting serum irisin and adiponectin were measured with enzyme-linked immunosorbent assay. Body composition and bone mineral density were assayed by dual energy X-ray absorptiometry.
  
  
  RESULTS
  Polycystic ovary syndrome women showed different body compositions compared with controls. Serum irisin level of PCOS did not show significant difference compared with controls although it was decreased. The level of adiponectin in PCOS patients was significantly reduced. BMI had no correlation with irisin level. It indicated a positive correlation between serum irisin levels and bone mineral density in the control group and a negative correlation in the PCOS group after BMI and age adjusted. Furthermore, total lean mass has a significant effect on irisin concentration in the PCOS group. There are no correlations between adiponection and body compositions and bone mineral density in both groups.
  
  
  CONCLUSIONS
  The abnormal body composition in PCOS may contribute to the circulation irisin. The crosstalk of irisin in different organs was found and may be related to disease development in PCOS.
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun, China.|School of Life Sciences, Jilin University, Changchun, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Endocrinology, the Second Hospital of Jilin University, Jilin University, Changchun, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Endocrinology, the Second Hospital of Jilin University, Jilin University, Changchun, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun, China.|School of Life Sciences, Jilin University, Changchun, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, the Second Hospital of Jilin University, Jilin University, Changchun, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D001823:Body Composition; D015519:Bone Density; D002096:C-Peptide / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011379:Prognosis; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D002096:C-Peptide; C577593:FNDC5 protein, human; D005353:Fibronectins
keywords: adiponectin; body composition; bone metabolism; irisin; polycystic ovary syndrome