title: Emerging biomarkers in psoriatic arthritis.
abstract: Psoriasis is an immune-mediated skin disease which affects 2-4% of the worldwide population. Approximately 20-30% of patients with psoriasis develop psoriatic arthritis (PsA), a frequently destructive and disabling condition. As skin manifestations precede joint symptoms in nearly all patients with PsA, identification of biomarkers for early prediction of joint damage is an important clinical need. Because not all patients with PsA respond to treatment in the same fashion, identification of biomarkers capable of predicting therapeutic response is also imperative. Here, we review existing literature and discuss current investigations to identify potential biomarkers for PsA disease activity, with particular emphasis on microRNAs as novel markers of interest. Serum (soluble) biomarkers, peripheral osteoclast precursor as cellular biomarkers, and genetic loci associated with skin and joint disease are also reviewed.
authors.affiliation: Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Paek
authors.affiliation: Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.|Immunology Program, Henry Ford Health System, Detroit, MI, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Immunology Program, Henry Ford Health System, Detroit, MI, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Weiland
authors.affiliation: Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
authors.forename: Chuan-Jian
authors.initials: CJ
authors.lastname: Lu
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: McKinnon
authors.affiliation: Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Immunology Program, Henry Ford Health System, Detroit, MI, USA.
authors.forename: Henry W
authors.initials: HW
authors.lastname: Lim
authors.affiliation: Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: James T
authors.initials: JT
authors.lastname: Elder
authors.affiliation: Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.|Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
authors.forename: Qing-Sheng
authors.initials: QS
authors.lastname: Mi
mesh_terms: D015535:Arthritis, Psoriatic / Q000097:blood* / Q000235:genetics* / Q000473:pathology; D015415:Biomarkers / Q000097:blood*; D005819:Genetic Markers; D006801:Humans; D035683:MicroRNAs; D010010:Osteoclasts / Q000473:pathology; D020641:Polymorphism, Single Nucleotide
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D035683:MicroRNAs
keywords: biomarkers; microRNAs; psoriatic arthritis