title: Two decades of new drug development for central nervous system disorders.
authors.affiliation: Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA.
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Kesselheim
authors.affiliation: Harvard University, Cambridge, Massachusetts, and Bain Capital, Boston, Massachusetts 02116, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hwang
authors.affiliation: Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Franklin
mesh_terms: D002491:Central Nervous System Agents; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D017277:Drug Approval / Q000379:methods*; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D010601:Pharmacology, Clinical / Q000639:trends
chemical_list: D002491:Central Nervous System Agents