title: European Group for Blood and Marrow Transplantation Centers with FACT-JACIE Accreditation Have Significantly Better Compliance with Related Donor Care Standards.
abstract: Previous studies have identified healthcare practices that may place undue pressure on related donors (RDs) of hematopoietic cell products and an increase in serious adverse events associated with morbidities in this population. As a result, specific requirements to safeguard RD health have been introduced to Foundation for the Accreditation of Cellular Therapy/The Joint Accreditation Committee ISCT and EBMT (FACT-JACIE) Standards, but the impact of accreditation on RD care has not previously been evaluated. A survey of transplant program directors of European Group for Blood and Marrow Transplantation member centers was conducted by the Donor Health and Safety Working Committee of the Center for International Blood and Marrow Transplant Research to test the hypothesis that RD care in FACT-JACIE accredited centers is more closely aligned with international consensus donor care recommendations than RD care delivered in centers without accreditation. Responses were received from 39% of 304 centers. Our results show that practice in accredited centers was much closer to recommended standards as compared with nonaccredited centers. Specifically, a higher percentage of accredited centers use eligibility criteria to assess RDs (93% versus 78%; P = .02), and a lower percentage have a single physician simultaneously responsible for an RD and their recipient (14% versus 35%; P = .008). In contrast, where regulatory standards do not exist, both accredited and nonaccredited centers fell short of accepted best practice. These results raise concerns that despite improvements in care, current practice can place undue pressure on donors and may increase the risk of donation-associated adverse events. We recommend measures to address these issues through enhancement of regulatory standards as well as national initiatives to standardize RD care.
authors.affiliation: Anthony Nolan Research Institute, London, United Kingdom. Electronic address: chloeanthias@anthonynolan.org.
authors.forename: Chloe
authors.initials: C
authors.lastname: Anthias
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Paul V
authors.initials: PV
authors.lastname: O'Donnell
authors.affiliation: Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, MN, USA.
authors.forename: Deidre M
authors.initials: DM
authors.lastname: Kiefer
authors.affiliation: Department of Medicine, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Jean
authors.initials: J
authors.lastname: Yared
authors.affiliation: Division of Hematology/Oncology, University of Florida, Florida College of Medicine, Gainesville, FL, USA.
authors.forename: Maxim
authors.initials: M
authors.lastname: Norkin
authors.affiliation: The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Anderlini
authors.affiliation: Division of Hematology/Oncology, Vanderbilt Medical Center, Nashville, TN, USA.
authors.forename: Bipin N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Department of Hematology/Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Diaz
authors.affiliation: Tel-Aviv Sourasky Medical Center, Israel.
authors.forename: Menachem
authors.initials: M
authors.lastname: Bitan
authors.affiliation: Department of Haematology, University Hospital Basel, Switzerland.
authors.forename: Joerg P
authors.initials: JP
authors.lastname: Halter
authors.affiliation: Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA; Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Brent R
authors.initials: BR
authors.lastname: Logan
authors.affiliation: University of Pittsburgh, VA Medical Healthcare System, Pittsburgh, PA, USA.
authors.forename: Galen E
authors.initials: GE
authors.lastname: Switzer
authors.affiliation: Children's Hospital of Los Angeles, USC Keck School of Medicine, Los Angeles, CA, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pulsipher
authors.affiliation: National Marrow Donor Program/Be The Match, Minneapolis, MN, USA.
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Confer
authors.affiliation: Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Bronwen E
authors.initials: BE
authors.lastname: Shaw
mesh_terms: D000068:Accreditation / Q000592:standards*; D046148:Donor Selection / Q000592:standards*; D005060:Europe; D005260:Female; D019983:Guideline Adherence / Q000592:standards*; D018380:Hematopoietic Stem Cell Transplantation / Q000592:standards; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D061349:Unrelated Donors
keywords: Accreditation; Hematopoietic cell donation; JACIE; Related donor