title: Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development.
abstract: The human gut contains a microbial community composed of tens of trillions of organisms that normally assemble during the first 2-3 y of postnatal life. We propose that brain development needs to be viewed in the context of the developmental biology of this "microbial organ" and its capacity to metabolize the various diets we consume. We hypothesize that the persistent cognitive abnormalities seen in children with undernutrition are related in part to their persistent gut microbiota immaturity and that specific regions of the brain that normally exhibit persistent juvenile (neotenous) patterns of gene expression, including those critically involved in various higher cognitive functions such as the brain's default mode network, may be particularly vulnerable to the effects of microbiota immaturity in undernourished children. Furthermore, we postulate that understanding the interrelationships between microbiota and brain metabolism in childhood undernutrition could provide insights about responses to injury seen in adults. We discuss approaches that can be used to test these hypotheses, their ramifications for optimizing nutritional recommendations that promote healthy brain development and function, and the potential societal implications of this area of investigation.
authors.affiliation: Neuroimaging Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110;
authors.forename: Manu S
authors.initials: MS
authors.lastname: Goyal
authors.affiliation: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110;
authors.forename: Siddarth
authors.initials: S
authors.lastname: Venkatesh
authors.affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Milbrandt
authors.affiliation: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110; jgordon@wustl.edu marc@npg.wustl.edu.
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Gordon
authors.affiliation: Neuroimaging Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110; jgordon@wustl.edu marc@npg.wustl.edu.
authors.forename: Marcus E
authors.initials: ME
authors.lastname: Raichle
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002648:Child; D015362:Child Nutrition Disorders / Q000378:metabolism* / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D000069196:Gastrointestinal Microbiome; D005786:Gene Expression Regulation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008954:Models, Biological
keywords: brain development; brain metabolism; childhood undernutrition; gut microbiota development