title: Oxygen Saturation Targeting and Bronchopulmonary Dysplasia.
abstract: Oxygen saturation targeting is widely used in neonatal intensive care, but the optimal target range in very preterm infants has been uncertain and is the subject of recent debate and research. This review briefly discusses the technology of oxygen monitoring and the role of oxygen toxicity in preterm infants. The background to the recent trials of oxygen saturation targeting in acute and continuing care of very preterm infants is reviewed, and the findings and implications of the recent trials, particularly with respect to bronchopulmonary dysplasia, are discussed.
authors.affiliation: Department of Paediatrics, University of Otago at Christchurch, PO Box 4345, Christchurch 8140, New Zealand. Electronic address: brian.darlow@otago.ac.nz.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Darlow
authors.affiliation: Department of Obstetrics and Gynaecology, University of Cambridge, 223, Level 2, The Rosie Hospital, Robinson Way, Cambridge CB2 2SW, UK.
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Morley
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000628:therapy*; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007234:Infant, Premature; D015931:Intensive Care, Neonatal; D010092:Oximetry; D010100:Oxygen / Q000009:adverse effects / Q000097:blood*; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects / Q000379:methods*; D010347:Patient Care Planning; D012178:Retinopathy of Prematurity / Q000209:etiology / Q000517:prevention & control
chemical_list: D010100:Oxygen
keywords: Bronchopulmonary dysplasia; Neonatal free radical disease; Oxygen saturation; Randomized controlled trial; Retinopathy of prematurity; Very preterm infant