title: Targeting STING pathways for the treatment of cancer.
abstract: Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.
authors.affiliation: Albert Einstein College of Medicine; Department of Microbiology and Immunology ; New York, NY USA.
authors.forename: Claudia
authors.initials: C
authors.lastname: Gravekamp
authors.affiliation: Albert Einstein College of Medicine; Department of Microbiology and Immunology ; New York, NY USA.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Chandra
keywords: IL-12; Listeria-Mage-b; STING ligand; c-di-GMP; metastatic breast cancer