title: [Expression and clinical significance of T lymphoma invasion and metastasis inducing factor 1 in oral squamous cell carcinoma].
abstract: OBJECTIVE
  T lymphoma invasion and metastasis inducing factor 1 (TIAM1) overexpression has been reported in a variety of human cancers. However, the investigation of TIAM1 in oral squamous cell carcinoma (OSCC) was extremely rare. The aim of the study was to assess TIAM1 expression and explore its role in OSCC.
  
  
  METHODS
  Immunohistochemistry staining was performed in 80 primary OSCC patients and 20 normal oral mucosa samples. The expression of TIAM1 and its association with clinicopathological parameters were analyzed using SPSS19.0 software package.
  
  
  RESULTS
  TIAM1 expression was significantly stronger in OSCC tissues (91.25%) compared with normal oral mucosa (10.00%); TIAM1 overexpression was significantly correlated with histological grade (P=0.019), clinical stage (P<0.001) and lymph node metastasis (P=0.004), but not significantly correlated with sex or age.
  
  
  CONCLUSIONS
  TIAM1 may play an important role in the occurrence, development and metastasis of OSCC, which may be a potentially therapeutic target in the future.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital of Central-South University. Changsha 410008;China.E-mail:linlu330@aliyun.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Lin
authors.forename: Jing-min
authors.initials: JM
authors.lastname: You
authors.forename: Yun-mei
authors.initials: YM
authors.lastname: Qian
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.forename: Hao-feng
authors.initials: HF
authors.lastname: Xiong
authors.forename: Tong
authors.initials: T
authors.lastname: Su
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D002465:Cell Movement; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D016399:Lymphoma, T-Cell / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000378:metabolism*; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1
chemical_list: D020662:Guanine Nucleotide Exchange Factors; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1; C087334:TIAM1 protein, human