title: Effect of cataract surgery on regulation of circadian rhythms.
abstract: This review looked at the effect of cataract surgery on the regulation of circadian rhythms and compared the effect of blue light-filtering and clear intraocular lenses (IOLs) on circadian rhythms. A systematic review and metaanalysis were performed, and the level of evidence was evaluated based on the principles described in the Grading of Recommendations Assessment, Development, and Evaluation system. A literature search of PubMed, Embase, and Cochrane Library databases was performed, as well as a search for unpublished trials at the U.S. National Institutes of Health Clinical Trials web site. Trials that reported the effect of cataract surgery on circadian rhythms were included. Outcomes were the Pittsburgh Sleep Quality Index (PSQI) global score, number of poor sleepers, Epworth Sleepiness Score, sleep efficiency, and mean concentration of melatonin. Cataract surgery improved regulation of circadian rhythms measured by the PSQI questionnaire, but the clinical relevance is uncertain. There was no difference between the effect of the 2 IOL types.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Faculty of Health and Medical Sciences (Erichsen), University of Copenhagen, Copenhagen, Department of Ophthalmology (Erichsen, Brøndsted), Glostrup Hospital, Glostrup, and Department of Ophthalmology (Kessel), Roskilde Hospital, Roskilde, Denmark. Electronic address: pcr974@alumni.ku.dk.
authors.forename: Jesper Høiberg
authors.initials: JH
authors.lastname: Erichsen
authors.affiliation: From the Faculty of Health and Medical Sciences (Erichsen), University of Copenhagen, Copenhagen, Department of Ophthalmology (Erichsen, Brøndsted), Glostrup Hospital, Glostrup, and Department of Ophthalmology (Kessel), Roskilde Hospital, Roskilde, Denmark.
authors.forename: Adam E
authors.initials: AE
authors.lastname: Brøndsted
authors.affiliation: From the Faculty of Health and Medical Sciences (Erichsen), University of Copenhagen, Copenhagen, Department of Ophthalmology (Erichsen, Brøndsted), Glostrup Hospital, Glostrup, and Department of Ophthalmology (Kessel), Roskilde Hospital, Roskilde, Denmark.
authors.forename: Line
authors.initials: L
authors.lastname: Kessel
mesh_terms: D000375:Aging / Q000502:physiology; D002387:Cataract Extraction; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D012165:Retinal Ganglion Cells / Q000502:physiology; D017299:Rod Opsins / Q000378:metabolism; D012893:Sleep Wake Disorders / Q000503:physiopathology; D000099210:Melanopsin
chemical_list: D017299:Rod Opsins; D000099210:Melanopsin