title: Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity.
abstract: Recent developments have demonstrated that metabolic rewiring imposed by adaptation of tissues to stress leads to the release of various metabolites which directly or indirectly impact innate immune responses and inflammation. Some metabolites can behave as second messengers and leave local cues in tissues. Immune cells which infiltrate stressed tissues reorient their metabolism to cope with these microenvironmental cues while preserving their effector functions in tissues.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France. Electronic address: naquet@ciml.univ-mrs.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Naquet
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Giessner
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Galland
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000276:immunology; D000222:Adaptation, Physiological / Q000276:immunology*; D000255:Adenosine Triphosphate / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D002952:Citric Acid Cycle / Q000276:immunology; D019610:Cytoprotection; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D055442:Metabolome / Q000276:immunology*; D010085:Oxidative Phosphorylation; D047493:PPAR alpha / Q000235:genetics / Q000276:immunology; D010944:Plants / Q000276:immunology; D015290:Second Messenger Systems / Q000276:immunology*; D013312:Stress, Physiological
chemical_list: D047493:PPAR alpha; D000255:Adenosine Triphosphate; D055372:AMP-Activated Protein Kinases