title: [The influence of electrical stimulation on the peripheral immune system under the experimental and clinical conditions].
abstract: The authors for the first time provide the scientifically-grounded substantiation for the application of electrical stimulation with bipolar pulsed currents for the combined treatment of the patents presenting with acne vulgaris. Experiments on the rabbits have demonstrated the influence of bipolar pulsed currents on the cellular composition of lymph nodes and thereby facilitated the better understanding of certain theoretical aspects of the application of electrical stimulation at large. The clinical study on the application of multi-channel electrical stimulation and microcurrent therapy showed that these physical factors may cause remodeling of immunogenesis in the patents presenting with acne vulgaris manifested as the normalization of the cellular composition of peripheral blood (leukocyte, lymphocyte, T- and B-lymphocyte counts and immunoglobulin levels). These findings confirm the effectiveness of the proposed integrated treatment responsible for the enhancement of the overall resistance of the patents with acne vulgaris. Moreover, this therapeutic modality proved to exert the immunocorrective action and promote the restoration of the adaptive capacity at large. As a result, 80.9% of the patients presenting with acne vulgaris enjoyed prolonged remission of the disease.
authors.affiliation: Federal state budgetary institution 'M.F. Vladimirsky Moscow Regional Clinical Research Institute', ul. Shchepkina, 61/2, Moscow, Russian Federation, 129110.
authors.forename: N N
authors.initials: NN
authors.lastname: Lazarenko
authors.affiliation: Federal state budgetary institution 'M.F. Vladimirsky Moscow Regional Clinical Research Institute', ul. Shchepkina, 61/2, Moscow, Russian Federation, 129110.
authors.forename: M V
authors.initials: MV
authors.lastname: Supova
authors.affiliation: Federal state budgetary institution 'M.F. Vladimirsky Moscow Regional Clinical Research Institute', ul. Shchepkina, 61/2, Moscow, Russian Federation, 129110.
authors.forename: O V
authors.initials: OV
authors.lastname: Trunova
authors.affiliation: Federal state budgetary institution 'M.F. Vladimirsky Moscow Regional Clinical Research Institute', ul. Shchepkina, 61/2, Moscow, Russian Federation, 129110.
authors.forename: S N
authors.initials: SN
authors.lastname: Smirnova
authors.affiliation: Federal state budgetary institution 'M.F. Vladimirsky Moscow Regional Clinical Research Institute', ul. Shchepkina, 61/2, Moscow, Russian Federation, 129110.
authors.forename: V F
authors.initials: VF
authors.lastname: Prikuls
mesh_terms: D000152:Acne Vulgaris / Q000276:immunology / Q000628:therapy*; D000328:Adult; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000528:radiation effects; D004558:Electric Stimulation; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008198:Lymph Nodes / Q000276:immunology / Q000528:radiation effects; D008297:Male; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects
chemical_list: D007136:Immunoglobulins