title: Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL).
abstract: Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.
authors.affiliation: Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo 11790, Egypt. mohamed_almallah@science.helwan.edu.eg.|Institut National de la Santé et de la Recherche Médicale, UMR866, Dijon F-21079, France. mohamed_almallah@science.helwan.edu.eg.
authors.forename: Mohammed I Y
authors.initials: MI
authors.lastname: Elmallah
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, UMR866, Dijon F-21079, France. olivier.micheau@inserm.fr.|Unité de Formation et de Recherche, Science de Santé, Dijon F-21079, France. olivier.micheau@inserm.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Micheau
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D059001:Aquatic Organisms; D044822:Biodiversity; D018533:Biomass; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D053221:TNF-Related Apoptosis-Inducing Ligand
keywords: Apoptosis; TNF; TRAIL; alkaloids; cancer; carotenoids; macrolactones; marine drugs; resistance; sesquiterpenes