title: Primary Extranodal Marginal Cell Lymphoma, MALT Type, of the Endometrium Arising in a Patient With Rheumatoid Arthritis: Report of a Case.
abstract: Primary marginal zone B-cell MALT-type lymphomas of the uterine corpus are exceedingly rare entities, with only 6 cases reported in the literature to date. We present the additional case of a 70-yr-old white woman who underwent a laparoscopic total hysterectomy with bilateral salpingo-oophorectomy for an asymptomatic ovarian cyst. At microscopic examination, endometrial samples showed a dense, nodular lymphocytic infiltrate, suggestive of a lymphoproliferative disorder. Morphology, immunohistochemistry, and molecular analysis supported the diagnosis of MALT-type lymphoma of the endometrium. Benign reactive conditions, such as endometritis and other small B-cell lymphomas were ruled out. Moreover, we investigated the pathogenesis of our case, focusing on Chlamydia trachomatis infection, chromosomal translocations affecting the NF-kB pathway, and discussing the role of autoimmunity in the development of MALT-type lymphomas.
authors.affiliation: Department of Surgical and Morphological Sciences (F.M., L.C., B.B., N.S., C.R., S.U.), University of Insubria, Varese Ospedale Moriggia-Pelascini (I.R.), Gravedona ed Uniti, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Magnoli
authors.forename: Laura
authors.initials: L
authors.lastname: Cimetti
authors.forename: Barbara
authors.initials: B
authors.lastname: Bernasconi
authors.forename: Nora
authors.initials: N
authors.lastname: Sahnane
authors.forename: Isabella
authors.initials: I
authors.lastname: Redaelli
authors.forename: Cristina
authors.initials: C
authors.lastname: Riva
authors.forename: Silvia
authors.initials: S
authors.lastname: Uccella
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D016328:NF-kappa B