title: [Bradykinin-induced angioedema: Definition, pathogenesis, clinical presentation, diagnosis and therapy].
abstract: The incidence of bradykinin-induced angioedema is considerably lower than that of histamine-induced forms; however, the same is true for the clinician's knowledge of this condition. Bradykinin-induced angioedemas include hereditary angioedema (HAE), as well as acquired forms induced by drugs or antibody formation, e.g., during the course of oncologic disease. Drug-induced forms affect almost exclusively the head and neck region, and are thus important for the otorhinolaryngologist. Clear differentiation between histamine-induced angioedema (e. g., connected to allergy/urticaria) and bradykinin-induced angioedema is essential for selection of the specific treatment and may be lifesaving. Antihistamines and cortisone derivatives have no relevant effect in bradykinin induced-angioedema, whereas blood-derived C1 esterase inhibitor and bradykinin receptor 2 antagonists represent effective therapeutic options--both for acute and prophylactic treatment.
authors.affiliation: Universitätsklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89070, Ulm, Deutschland. Janina.Hahn@uniklinik-ulm.de.
authors.forename: J
authors.initials: J
authors.lastname: Hahn
authors.affiliation: Hals-Nasen-Ohren-Klinik und Poliklinik, Technische Universität München, München, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Bas
authors.affiliation: Universitätsklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89070, Ulm, Deutschland.
authors.forename: T K
authors.initials: TK
authors.lastname: Hoffmann
authors.affiliation: Universitätsklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89070, Ulm, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Greve
mesh_terms: D000799:Angioedema / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D001920:Bradykinin / Q000378:metabolism*; D065094:Bradykinin B2 Receptor Antagonists / Q000008:administration & dosage*; D050718:Complement C1 Inhibitor Protein / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D006801:Humans; D016896:Treatment Outcome
chemical_list: D065094:Bradykinin B2 Receptor Antagonists; D050718:Complement C1 Inhibitor Protein; D001920:Bradykinin
keywords: Angiotensin-converting enzyme inhibitor; Antibodies; C1 esterase inhibitor; Hereditary angioneurotic edema; Vascular diseases