title: Encapsulation and in vitro release of erythromycin using biopolymer micelle.
abstract: An amphiphilic block copolymer poly(ethylene glycol)-block-poly[2-(2-methoxyethoxy)ethyl methacrylate] (PEG-b-PMEO2MA) was prepared and the polymer micelle was applied to encapsulate erythromycin. The Critical Micelle Concentration (CMC) of PEG-b-PMEO2MA was determined by the fluorescent probe pyrene. The effects of addition of erythromycin on encapsulation efficiency and drug loading content were investigated. Drug release was also studied in a phosphate buffer solution with a pH of 7.5. The CMC of PEG-b-PMEO2MA is 0.065 mg/mL when the monomer ratio of the hydrophobic block PMEO2MA to the hydrophilic block PEG is equal to 6:4. The encapsulation efficiency and drug loading were 87.1% and 16.8%, respectively, as the loading content of erythromycin in polymeric micelle is equal to 28%. After erythromycin is loaded into the micelle, the size of PEG-b-PMEO2MA micelle becomes approximately thrice the size of unloaded micelle. The loading micelles stably release erythromycin within 180 hours in phosphate buffer, suggesting that the micelle loaded with erythromycin have a good sustained-release effect.
authors.affiliation: Jiangnan University School of Pharmaceutical Science Jiangsu China yanhuang69@yeah.net.
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Jiangnan University School of Pharmaceutical Science Jiangsu China.
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Jiangnan University School of Pharmaceutical Science Jiangsu China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002021:Buffers; D002214:Capsules / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics; D004917:Erythromycin / Q000737:chemistry* / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D002021:Buffers; D002214:Capsules; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D011109:Polymethacrylic Acids; C000610406:poly(ethylene glycol)-block-poly(2-(2-methoxyethoxy)ethyl methacrylate); D011092:Polyethylene Glycols; D004917:Erythromycin