title: Interacting sources of interference during sensorimotor integration processes.
abstract: Every day, a multitude of interfering sensory inputs needs to be integrated and adequately processed using response selection processes. Interference effects are typically investigated using classical paradigms like the Flanker and Simon task. The sources of interference for Flanker and Simon effect are known to be different and according to dual process accounts, two distinct functional pathways are involved in resolving these types of interference. It is an open question how far these sources of interference are related to each other and interact. We investigated this question in a system neurophysiological study utilizing a hybrid paradigm combining both Flanker effect-like and Simon effect-like features. We focus on event-related theta oscillations and use beamforming methods to examine functional neuroanatomical networks. The results show that Simon and Flanker interference interacted in a non-additive fashion by modulating theta band activity, probably reflecting the recruitment of cognitive control processes. Beamforming source reconstruction revealed that theta band activity was related to a broad neuronal network comprising prefrontal and cerebellar regions, including the MFG, SFG, IFG, and SMA. These regions were connected to interference processing and conflict resolution, but differed in the amount of specificity for different sources of interference.
authors.affiliation: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Germany. Electronic address: Moritz.mueckschel@uniklinikum-dresden.de.
authors.forename: Moritz
authors.initials: M
authors.lastname: Mückschel
authors.affiliation: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Germany.
authors.forename: Ann-Kathrin
authors.initials: AK
authors.lastname: Stock
authors.affiliation: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Germany.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dippel
authors.affiliation: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Germany.
authors.forename: Witold
authors.initials: W
authors.lastname: Chmielewski
authors.affiliation: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Beste
mesh_terms: D001921:Brain / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D055815:Young Adult
keywords: Beamforming; EEG; Flanker task; Interference; Sensorimotor processes; Simon task; Theta