title: Prospective Study of Malabsorption and Malnutrition After Esophageal and Gastric Cancer Surgery.
abstract: OBJECTIVE
  To study malabsorption and malnutrition after curative resection of esophageal and gastric cancer.
  
  
  METHODS
  Prospective cohort study.
  
  
  BACKGROUND
  Improved cure rates for esophageal and gastric cancer have increased focus on health-related quality of life (HR-QL) in survivorship. Although malnutrition is well described in long-term follow-up, and gastrointestinal symptoms are common, data on gut and pancreatic-related malabsorption are scant.
  
  
  METHODS
  Disease-free patients at least 18 months after esophageal or gastric oncologic resections represented the study cohort. A modified Gastrointestinal Symptom Rating Scale questionnaire was completed, and weight, fecal elastase (FE), albumin, vitamins, and micronutrients measured preoperatively and at 1, 6, and 18 to 24 months postoperatively. Small intestinal bacterial overgrowth (SIBO) and changes in body composition were also evaluated postoperatively.
  
  
  RESULTS
  At a median follow-up of 23 months, 45 of 66 patients in a consecutive series were disease-free. Mean weight (78 ± 19 vs 67 ± 16 kg), body mass index (27 ± 5 vs 24 ± 5 kg/m), Vitamin A (1.7 ± 0.6 vs 1.2 ± 0.4 umol/L), and Vitamin E (28 ± 7 vs 20 ± 7 umol/L) were significantly decreased (P < 0.01) at last follow-up compared with preoperatively. Malabsorption was evident in 73% of patients, of whom 44% had FE < 200 μg/g and 38% had evidence of SIBO. Total body fat-free mass (175 ± 96 vs 84 ± 71, P < 0.001) and skeletal muscle index (44 ± 8 vs 39 ± 8, P = 0.007) were significantly decreased at 18 to 24 months.
  
  
  CONCLUSIONS
  Malabsorption and malnutrition are prevalent in survivorship of esophageal and stomach cancer. This may be underappreciated, and both gut and pancreatic insufficiency represent modifiable targets in the interdisciplinary approach to recovery of HR-QL.
authors.affiliation: Department of Surgery, Trinity College Dublin, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Heneghan
authors.forename: Alexandra
authors.initials: A
authors.lastname: Zaborowski
authors.forename: Michelle
authors.initials: M
authors.lastname: Fanning
authors.forename: Aisling
authors.initials: A
authors.lastname: McHugh
authors.forename: Suzanne
authors.initials: S
authors.lastname: Doyle
authors.forename: Jenny
authors.initials: J
authors.lastname: Moore
authors.forename: Nayarasamy
authors.initials: N
authors.lastname: Ravi
authors.forename: John V
authors.initials: JV
authors.lastname: Reynolds
mesh_terms: D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007494:Ireland / Q000453:epidemiology; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D044342:Malnutrition / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D011446:Prospective Studies; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000601:surgery*; D013997:Time Factors