title: Mannose-binding lectin polymorphisms and rheumatoid arthritis: A short review and meta-analysis.
abstract: Mannose-binding lectin (MBL) is a pattern recognition receptor of the lectin pathway of complement system. MBL binds to carbohydrates on microorganism's surfaces leading to complement activation, opsonization and phagocytosis. Polymorphisms in the MBL gene (MBL2) are associated with variations on MBL serum levels and with the susceptibility to various infectious and autoimmune diseases. The involvement of the lectin pathway in rheumatoid arthritis (RA) has been demonstrated by several studies and although MBL has been considered to have a dual role in the pathogenesis of the disease, the association between MBL and RA remains inconclusive. In an attempt to clarify this relationship, we developed this short review summarizing accumulated evidences in regard to MBL and RA and a meta-analysis to evaluate the influence of MBL2 polymorphisms on the susceptibility to RA. Among a total of 217 articles that were identified following a predefined search strategy on PubMed, Scopus, Scielo, EMBASE and Cochrane databases, only 13 met all inclusion criteria and were included in the meta-analysis. Data assessment was conducted by three independent investigators and presented in odds ratio (OR) and 95% confidence intervals (CIs) using forest plot charts. Both heterogeneity and publication bias were analyzed. The results of the meta-analysis evidenced that MBL2 low producing OO and XX genotypes do not confer higher risk to RA, even when data were analyzed according to cohort's ethnicity. Further studies are needed in order to clarify the importance of other genes of the lectin pathway in the pathogenesis of RA.
authors.affiliation: Laboratory of Molecular Immunopatology-Department of Clinical Pathology, Hospital de Clínicas, Universidade Federal do Paraná, Rua General Carneiro, 181, Alto da Glória, Curitiba, PR, Brazil. Electronic address: stefi_epp@yahoo.com.br.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Epp Boschmann
authors.affiliation: Laboratory of Molecular Immunopatology-Department of Clinical Pathology, Hospital de Clínicas, Universidade Federal do Paraná, Rua General Carneiro, 181, Alto da Glória, Curitiba, PR, Brazil.
authors.forename: Isabela
authors.initials: I
authors.lastname: Goeldner
authors.affiliation: Division of Infectious Diseases, Hospital de Clínicas, Universidade Federal do Paraná, Rua General Carneiro, 181, Alto da Glória, Curitiba, PR, Brazil.
authors.forename: Felipe Francisco
authors.initials: FF
authors.lastname: Tuon
authors.affiliation: Laboratory of Molecular Immunopatology-Department of Clinical Pathology, Hospital de Clínicas, Universidade Federal do Paraná, Rua General Carneiro, 181, Alto da Glória, Curitiba, PR, Brazil.
authors.forename: Wagner
authors.initials: W
authors.lastname: Schiel
authors.affiliation: Laboratory of Molecular Immunopatology-Department of Clinical Pathology, Hospital de Clínicas, Universidade Federal do Paraná, Rua General Carneiro, 181, Alto da Glória, Curitiba, PR, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Aoyama
authors.affiliation: Laboratory of Molecular Immunopatology-Department of Clinical Pathology, Hospital de Clínicas, Universidade Federal do Paraná, Rua General Carneiro, 181, Alto da Glória, Curitiba, PR, Brazil. Electronic address: iara.reason@hc.ufpr.br.
authors.forename: Iara J
authors.initials: IJ
authors.lastname: de Messias-Reason
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D037601:Mannose-Binding Lectin / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin
keywords: MBL2; Mannose binding lectin; Meta-analysis; Polymorphisms; Rheumatoid arthritis