title: Association between microRNA-499 polymorphism and gastric cancer risk in Chinese population.
abstract: Single-nucleotide polymorphisms in microRNAs are related to the occurrence, development and prognosis of cancer. The aim of the present study is to investigate the possible influence of the miR-499(rs3746444) polymorphism on the risk of gastric cancer in Chinese population. A total of 363 GC patients and 969 cancer-free controls were enrolled in this study. The genotypes were obtained using MassARRAY method. The results showed that, compared with T allele, C allele was associated with a significantly increased risk of GC (OR=1.491, 95% CI=1.155-1.923, P=0.002). Moreover, a significantly increased risk of GC in subjects with the TC genotype was observed (adjusted OR of 1.559, 95% CI=1.148-2.117, P=0.004), compared with the wide type TT. We also found that basically dominant model (TT vs. TC+CC) was suitable for the association between rs6513497 and the risk of GC (OR=1.568, 95% CI=1.173-2.097, P=0.002). However, the same association was also shown in males and females. Meanwhile, rs3746444 was associated with the tumor size of GC patients. The present study indicated that miR-499 rs3746444 might contribute to GC risk and this SNP could be developed as a biomarker for GC prediction.
authors.affiliation: Tongji University School of Medicine, Shanghai Yangpu District Central Hospital, Department of Digestive Diseases, China.
authors.forename: Min
authors.initials: M
authors.lastname: Cai
authors.affiliation: Huashan Hospital, Fudan University, Department of Digestive Diseases, 12, Middle Wulumuqi Road, 200040 Shanghai, China.
authors.forename: Yitong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Huashan Hospital, Fudan University, Department of Digestive Diseases, 12, Middle Wulumuqi Road, 200040 Shanghai, China.
authors.forename: Wenshuai
authors.initials: W
authors.lastname: Li
authors.affiliation: Southeast Hospital, Xiamen University, Department of Digestive Diseases, Zhangzhou, Fujian, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Min
authors.affiliation: Huadong Hospital, Fudan University, Department of General Surgery, Shanghai, China.
authors.forename: Jigang
authors.initials: J
authors.lastname: Qiu
authors.affiliation: Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Department of Clinical Laboratory, Shanghai, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Xu
authors.affiliation: Southeast Hospital, Xiamen University, Department of Digestive Diseases, Zhangzhou, Fujian, China.
authors.forename: Mingqing
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Renji Hospital, Shanghai Jiao Tong University School of Medicine, Department of Clinical Laboratory, Shanghai, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Shanghai Yangpu District Central Hospital, Tongji University School of Medicine, Department of Digestive Diseases, 450, Tengyue Road, 200082 Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Huashan Hospital, Fudan University, Department of Digestive Diseases, 12, Middle Wulumuqi Road, 200040 Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Huashan Hospital, Fudan University, Department of Digestive Diseases, 12, Middle Wulumuqi Road, 200040 Shanghai, China.
authors.forename: Dongqin
authors.initials: D
authors.lastname: Yang
authors.affiliation: Huashan Hospital, Fudan University, Department of Digestive Diseases, 12, Middle Wulumuqi Road, 200040 Shanghai, China. Electronic address: archsteed@gmail.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Shanghai Yangpu District Central Hospital, Tongji University School of Medicine, Department of Digestive Diseases, 450, Tengyue Road, 200082 Shanghai, China. Electronic address: ftao216@163.com.
authors.forename: Fengtao
authors.initials: F
authors.lastname: Cheng
mesh_terms: D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D047368:Tumor Burden / Q000235:genetics
chemical_list: D005819:Genetic Markers; C548683:MIRN499 microRNA, human; D035683:MicroRNAs
keywords: Gastric cancer; MiR-499; Single nucleotide polymorphism