title: Association of recently described adipokines with liver histology in biopsy-proven non-alcoholic fatty liver disease: a systematic review.
abstract: The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising, as is the prevalence of obesity and type 2 diabetes. It is increasingly recognized that an impaired pattern in adipokine secretion could play a pivotal role in the development of NAFLD. We performed a systematic review to evaluate the potential link between newly described adipokines and liver histology in biopsy-proven NAFLD patients. A computerized literature search was performed in PubMed, EMBASE and Web of Science electronic databases. Thirty-one cross-sectional studies were included, resulting in a total of seven different investigated adipokines. Studies included in this review mainly had a good methodological quality. Most adipokines were suggested to be involved in the inflammatory response that develops within the context of NAFLD, either at hepatic or systemic level, and/or hepatic insulin resistance. Based on literature, clinical studies suggest that chemerin, resistin and adipocyte-fatty-acid-binding protein potentially are involved in NAFLD pathogenesis and/or progression. However, major inconsistency still exists, and there is a high need for larger studies, together with the need of standardized assays to determine adipokine levels.
authors.affiliation: Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Bekaert
authors.affiliation: Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.
authors.forename: X
authors.initials: X
authors.lastname: Verhelst
authors.affiliation: Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Geerts
authors.affiliation: Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Lapauw
authors.affiliation: Revalidation Science and Physiotherapy, Ghent University Hospital, Ghent, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Calders
mesh_terms: D054392:Adipokines / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000473:pathology* / Q000503:physiopathology; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000503:physiopathology
chemical_list: D054392:Adipokines; D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins
keywords: Adipokines; insulin resistance; liver histology; non-alcoholic fatty liver disease