title: Circadian Rhythm Sleep-Wake Disorders.
abstract: The circadian system regulates the timing and expression of nearly all biological processes, most notably, the sleep-wake cycle, and disruption of this system can result in adverse effects on both physical and mental health. The circadian rhythm sleep-wake disorders (CRSWDs) consist of 5 disorders that are due primarily to pathology of the circadian clock or to a misalignment of the timing of the endogenous circadian rhythm with the environment. This article outlines the nature of these disorders, the association of many of these disorders with psychiatric illness, and available treatment options.
authors.affiliation: Department of Neurology, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Suite 500, Chicago, IL 60611, USA.
authors.forename: Sabra M
authors.initials: SM
authors.lastname: Abbott
authors.affiliation: Department of Neurology, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Suite 500, Chicago, IL 60611, USA.
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Reid
authors.affiliation: Department of Neurology, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Suite 500, Chicago, IL 60611, USA. Electronic address: p-zee@northwestern.edu.
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Zee
mesh_terms: D006801:Humans; D010789:Phototherapy; D020178:Sleep Disorders, Circadian Rhythm / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology* / Q000628:therapy*
keywords: Advanced sleep phase type; Circadian rhythm sleep-wake disorders; Delayed sleep phase type; Irregular sleep-wake type; Non-24-hour sleep-wake type; Shift work type