title: Direct Catalytic Asymmetric Synthesis of β-Hydroxy Acids from Malonic Acid.
abstract: A nickel(II) catalyzed asymmetric synthesis of β-hydroxy acids from malonic acid and ketones was developed, revealing for the first time the synthetic utility of malonic acid in the construction of chiral carboxyl acids; importantly, the synthetic potential of this strategy was further demonstrated by the rapid construction of cephalanthrin A, phaitanthrin B, cruciferane, and rice metabolites.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou, Zhejiang Province P.R. China.
authors.forename: Hang
authors.initials: H
authors.lastname: Gao
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou, Zhejiang Province P.R. China.
authors.forename: Zhenli
authors.initials: Z
authors.lastname: Luo
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou, Zhejiang Province P.R. China.
authors.forename: Pingjin
authors.initials: P
authors.lastname: Ge
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou, Zhejiang Province P.R. China.
authors.forename: Junqian
authors.initials: J
authors.lastname: He
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou, Zhejiang Province P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou, Zhejiang Province P.R. China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Zheng
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou, Zhejiang Province P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D006880:Hydroxy Acids / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure; D052999:Quinazolinones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D006880:Hydroxy Acids; D007659:Ketones; D058116:Lewis Acids; D008314:Malonates; D052999:Quinazolinones; C000606657:cephalanthrin A; C587287:cruciferane; C000606658:phaitanthrin B; C030290:malonic acid