title: ISG15: A double edged sword in cancer.
abstract: Interferon-Stimulated Gene 15(ISG15) transcript is aberrantly expressed in most human malignancies, suggesting that it has a protumor function. However, at the protein level ISG15 has both protumor and immunomodulatory antitumor functions. Therapeutic strategies to maximize the latter may benefit cancer patients overexpressing the ISG15 pathway.
authors.affiliation: Department of Biochemistry & Molecular Biology; LSU Health Sciences Center-School of Medicine ; New Orleans, LA USA.
authors.forename: Shyamal D
authors.initials: SD
authors.lastname: Desai
keywords: ISG15; cancer; immune system; immunostimulatory cytokine; ubiquitin/26S proteasome