title: A Method for Detection of Cholesterol Synthesis in the Placenta during Exacerbation of Cytomegalovirus Infection.
abstract: Histochemical analysis showed that exacerbation of cytomegalovirus infection even at early terms of gestation (weeks 5-6) suppresses synthesis of mevalonic acid, squalene, and 7α-dehydrocholesterol dehydrogenase in the placenta. Inhibition of cholesterol biosynthesis in the placenta at the early stages of gestation decreases production of sex hormones, reduces cholesterol concentration in the maternal peripheral blood, and impairs cholesterol supply to the fetus, which is associated with the risk of placental insufficiency.
authors.affiliation: Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia. lucenkomt@mail.ru.
authors.forename: M T
authors.initials: MT
authors.lastname: Lutsenko
authors.affiliation: Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Dovzhikova
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002784:Cholesterol / Q000096:biosynthesis*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D008798:Mevalonic Acid / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D010927:Placental Insufficiency / Q000209:etiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism*; D011261:Pregnancy Trimester, First; D013185:Squalene / Q000378:metabolism
chemical_list: D012739:Gonadal Steroid Hormones; D013185:Squalene; D002784:Cholesterol; D006913:Hydroxysteroid Dehydrogenases; C025376:7 alpha-hydroxysteroid dehydrogenase; D008798:Mevalonic Acid
keywords: cholesterol; cytomegalovirus infection; placenta