title: Complement component 3: a new paradigm in tuberculosis vaccine.
abstract: Vaccines are critical for the control of tuberculosis (TB) affecting humans and animals worldwide. First-generation vaccines protect from active TB but new vaccines are required to protect against pulmonary disease and infection. Recent advances in post-genomics technologies have allowed the characterization of host-pathogen interactions to discover new protective antigens and mechanisms to develop more effective vaccines against TB. Studies in the wild boar model resulted in the identification of complement component 3 (C3) as a natural correlate of protection against TB. Oral immunization with heat-inactivated mycobacteria protected wild boar against TB and showed that C3 plays a central role in protection. These results point at C3 as a target to develop novel vaccine formulations for more effective protection against TB in humans and animals.
authors.affiliation: a SaBio, Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM) , Ciudad Real , Spain.|b Department of Veterinary Pathobiology , Center for Veterinary Health Sciences, Oklahoma State University , Stillwater , OK , USA.
authors.forename: José
authors.initials: J
authors.lastname: De La Fuente
authors.affiliation: a SaBio, Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM) , Ciudad Real , Spain.
authors.forename: Christian
authors.initials: C
authors.lastname: Gortázar
authors.affiliation: c Departamento de Sanidad Animal , NEIKER-Tecnalia. Instituto Vasco de Investigación y Desarrollo Agrario , Derio , Vizcaya , Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Juste
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003176:Complement C3 / Q000378:metabolism*; D004195:Disease Models, Animal; D034421:Sus scrofa; D016896:Treatment Outcome; D014376:Tuberculosis / Q000276:immunology* / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D003176:Complement C3; D032581:Tuberculosis Vaccines
keywords: Complement; immunology; mycobacteria; tuberculosis; vaccine