title: The genomic sequence of lymphocryptovirus from cynomolgus macaque.
abstract: Lymphocryptoviruses such as Epstein-Barr virus (EBV) cause persistent infections in human and non-human primates, and suppression of the immune system can increase the risk of lymphocryptovirus (LCV)-associated tumor development in both human and non-human primates. To enable LCV infection as a non-clinical model to study effects of therapeutics on EBV immunity, we determined the genomic DNA sequence of the LCV from cynomolgus macaque, a species commonly used for non-clinical testing. Comparison to rhesus macaque LCV and human EBV sequences indicates that LCV from the cynomolgus macaque has the same genomic arrangement and a high degree of similarity in most genes, especially with rhesus macaque LCV. Genes showing lower similarity were those encoding proteins involved in latency and/or tumor promotion or immune evasion. The genomic sequence of LCV from cynomolgus macaque should aid the development of non-clinical tools for identifying therapeutics that impact LCV immunity and carry potential lymphoma risk.
authors.affiliation: Drug Safety Research and Development, Pfizer Global Research and Development, Pfizer, Inc., Groton, CT, USA. Electronic address: cris.kamperschroer@pfizer.com.
authors.forename: Cris
authors.initials: C
authors.lastname: Kamperschroer
authors.affiliation: Drug Safety Research and Development, Pfizer Global Research and Development, Pfizer, Inc., Groton, CT, USA.
authors.forename: Mark M
authors.initials: MM
authors.lastname: Gosink
authors.affiliation: Drug Safety Research and Development, Pfizer Global Research and Development, Pfizer, Inc., Groton, CT, USA.
authors.forename: Steven W
authors.initials: SW
authors.lastname: Kumpf
authors.affiliation: Drug Safety Research and Development, Pfizer Global Research and Development, Pfizer, Inc., Groton, CT, USA.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: O'Donnell
authors.affiliation: Drug Safety Research and Development, Pfizer Global Research and Development, Pfizer, Inc., Groton, CT, USA.
authors.forename: Karrie R
authors.initials: KR
authors.lastname: Tartaro
mesh_terms: D000818:Animals; D004279:DNA, Viral / Q000737:chemistry* / Q000235:genetics*; D023061:Gene Order; D016679:Genome, Viral; D018143:Lymphocryptovirus / Q000235:genetics* / Q000302:isolation & purification*; D008252:Macaca fascicularis / Q000821:virology*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D026801:Synteny
chemical_list: D004279:DNA, Viral
keywords: Cynomolgus; EBV; Genome; Lymphocryptovirus; Macaque; NHP; Non-human primate; Sequence; herpesvirus