title: Critical care admission trends and outcomes in individuals with bronchiectasis in the UK.
abstract: BACKGROUND
  There are limited data on admission trends and outcomes of individuals with bronchiectasis admitted to intensive care (ICU). Using national critical care data, we analysed admissions to ICU and estimated outcomes in terms of mortality in individuals with bronchiectasis and chronic obstructive pulmonary disease (COPD) admitted to ICU.
  
  
  METHODS
  Using data from the Intensive Care National Audit and Research Centre, admissions from bronchiectasis and COPD from 1 January 2009 to 31 December 2013 were extracted. Crude admission rates for bronchiectasis and COPD were calculated and Poisson regression was used to estimate unadjusted annual admission rate ratios. We investigated changes to length of stay on ICU, ICU mortality and in-hospital mortality during the study period. We also compared mortality rates in people with bronchiectasis and COPD aged 70 or above.
  
  
  RESULTS
  We found an annual increase of 8% (95% Confidence Interval [CI] 2-15) in the number of ICU admissions from bronchiectasis, whilst the yearly increase in ICU admissions from COPD was 1% (95% CI 0.3-2). ICU and in-hospital mortality was higher in individuals with bronchiectasis compared with those with COPD, especially in people aged 70 years or above.
  
  
  CONCLUSIONS
  Admission to ICU in people with bronchiectasis are uncommon, but are increasing in frequency over time, and carries a substantial mortality rate. This needs to be considered allocating health care resources and planning respiratory services.
authors.affiliation: From the Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK BronchUK, a MRC Funded Partnership in Bronchiectasis vidya.navaratnam@nottingham.ac.uk.
authors.forename: Vidya
authors.initials: V
authors.lastname: Navaratnam
authors.affiliation: BronchUK, a MRC Funded Partnership in Bronchiectasis Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Colin R
authors.initials: CR
authors.lastname: Muirhead
authors.affiliation: From the Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK BronchUK, a MRC Funded Partnership in Bronchiectasis.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hubbard
authors.affiliation: BronchUK, a MRC Funded Partnership in Bronchiectasis Institute of Cellular Medicine, Newcastle University & Sir William Leech Centre, Newcastle upon Tyne, UK.
authors.forename: Anthony
authors.initials: A
authors.lastname: De Soyza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001987:Bronchiectasis / Q000401:mortality*; D016208:Databases, Factual; D005260:Female; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data / Q000639:trends*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010343:Patient Admission / Q000706:statistics & numerical data / Q000639:trends*; D029424:Pulmonary Disease, Chronic Obstructive / Q000401:mortality*; D012044:Regression Analysis; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult