title: Intracellular antigens as targets for antibody based immunotherapy of malignant diseases.
abstract: This review discusses the potential use of intracellular tumor antigens as targets of antibody-based immunotherapy for the treatment of solid tumors. In addition, it describes the characteristics of the intracellular tumor antigens targeted with antibodies which have been described in the literature and have been identified in the authors' laboratory. Finally, the mechanism underlying the trafficking of the intracellular tumor antigens to the plasma membrane of tumor cells are reviewed.
authors.affiliation: Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
authors.forename: Xinhui
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
authors.forename: Cristina R
authors.initials: CR
authors.lastname: Ferrone
authors.affiliation: Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Schwab
authors.affiliation: Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States; Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States. Electronic address: sferrone@mgh.harvard.edu.
authors.forename: Soldano
authors.initials: S
authors.lastname: Ferrone
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D000091342:Endoplasmic Reticulum Chaperone BiP; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000628:therapy*
chemical_list: D000951:Antigens, Neoplasm; D000091342:Endoplasmic Reticulum Chaperone BiP; C000717247:HSPA5 protein, human
keywords: Grp78; Grp94; Hsp70; Intracellular tumor antigen; Monoclonal antibodies; PRL-3