title: Direct Amidation of N-Boc- and N-Cbz-Protected Amines via Rhodium-Catalyzed Coupling of Arylboroxines and Carbamates.
abstract: N-Boc- and N-Cbz-protected amines are directly converted into amides by a novel rhodium-catalyzed coupling of arylboroxines and carbamates, replacing the traditional two-step deprotection-condensation sequence. Both protected anilines and aliphatic amines are efficiently transformed into a wide variety of secondary benzamides, including sterically hindered and electron-deficient amides, as well as in the presence of acid-labile and reducible functional groups.
authors.affiliation: Institute of Bioengineering and Nanotechnology , 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
authors.forename: Diane S W
authors.initials: DS
authors.lastname: Lim
authors.affiliation: Institute of Bioengineering and Nanotechnology , 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
authors.forename: Tedrick T S
authors.initials: TT
authors.lastname: Lew
authors.affiliation: Institute of Bioengineering and Nanotechnology , 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
authors.forename: Yugen
authors.initials: Y
authors.lastname: Zhang