title: Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease.
abstract: One of the early pathological hallmarks of Alzheimer׳s disease (AD) is the deposition of amyloid-β (Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence (NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review, we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Tong
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Kaiyan
authors.initials: K
authors.lastname: Lou
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, Shanghai 200237, China ; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131-0001, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
keywords: AD, Alzheimer’s disease; APP, amyloid peptide precursor; Ach, acetylcholine; Alzheimer׳s disease; Amyloid-β plagues; Aβ, amyloid-β; BAP, BODIPY-based Ab imaging probe; BBB, blood-brain barrier; Blood-brain barrier; Cy, cyanine dyes; Fluorescence probe; ICG, indocyanine green dyes; MRI, magnetic resonance imaging; NIR, near-infrared; NIRF, near-infrared fluorescence; Near-infrared fluorescence; Optical imaging; PET, positron emission tomography; ROS, reactive oxygen species; SPECT, single photon emission computed tomography