title: Genetic Associations of Interleukin-related Genes with Graves' Ophthalmopathy: a Systematic Review and Meta-analysis.
abstract: Graves' ophthalmopathy (GO) is the commonest extra-thyroidal manifestation of Graves' disease (GD). Associations between interleukin-related (IL) gene polymorphisms and GO have been reported in different populations. We aim to confirm such associations by conducting a meta-analysis. Totally 382 publications were retrieved in MEDLINE and EMBASE up to 25/2/2015. After removing the duplicates and assessing the studies, we retrieved 16 studies that met the selection criteria for meta-analysis, involving 12 polymorphisms in 8 IL-related genes, and 1650 GO cases and 2909 GD controls. The summary odds ratio (OR) and 95% confidence intervals (CI) were estimated. We found one polymorphism in IL1A (rs1800587, c.-889C>T) showing a suggestive association with GO in the meta-analysis (allelic model [T vs. C]: OR = 1.62, 95% CI: 1.00-2.62, P = 0.050, I(2) = 53.7%; recessive model [TT vs. TC + CC]: OR = 2.39, 95% CI: 1.07-5.37, P = 0.039, I(2) = 23.6%; heterozygous model [TC vs. CC]: OR = 1.52, 95% CI: 1.04-2.22, P = 0.034, I(2) = 37.0%). No association with GO was detected for the other 7 genes (IL1B, IL1RA, IL4, IL6, IL12B, IL13 and IL23R). Our results thus indicate that IL1A is likely to be a genetic biomarker for GO. Further studies with larger sample sizes are warranted to confirm the associations of IL1A and other IL-related genes with GO.
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Kah Hie
authors.initials: KH
authors.lastname: Wong
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Shi Song
authors.initials: SS
authors.lastname: Rong
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.|Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.
authors.forename: Kelvin K L
authors.initials: KK
authors.lastname: Chong
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.|Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.
authors.forename: Alvin L
authors.initials: AL
authors.lastname: Young
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Chi Pui
authors.initials: CP
authors.lastname: Pang
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.|Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.
authors.forename: Li Jia
authors.initials: LJ
authors.lastname: Chen
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D049970:Graves Ophthalmopathy / Q000235:genetics*; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
chemical_list: D007378:Interleukins