title: [Advances in Research of Osteopontion and Its Receptor CD44v in Tumor Invasion and Metastasis].
abstract: Osteopontin (OPN) is a multifunctional, extracellular matrix-associated, secretory, glyco-protein. It can be used as an adhesion protein involved in tumor cell adhesion,migration; but also as a cytokine, promoting tumor angiogenesis, evading immune surveillance and inhibiting cellular apoptosis. CD44v glycoprotein, is one of the cell surface adhesion molecule that mediates cell-matrix and cell-cell interactions. Extensive research has suggested the important role of OPN in regulating signaling pathways that contribute to tumor progression and metastasis, and the serum level is associated with the prognosis of various malignancies. Therefore, clarifying OPN in the molecular mechanisms of tumor progression and its signaling pathway contributes to seeking a novel anti-cancer therapy.
authors.affiliation: Department of Lung Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
authors.forename: Bingsheng
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Lung Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
authors.forename: Zhenfa
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D018960:Hyaluronan Receptors / Q000737:chemistry / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D053495:Osteopontin / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D053495:Osteopontin