title: Adipose Tissue: Sanctuary for HIV/SIV Persistence and Replication.
abstract: This commentary highlights new findings from a recent study identifying adipose tissue as a potential HIV reservoir and a major site of inflammation during chronic human/simian immunodeficiency virus (HIV/SIV) infection. A concise discussion about upcoming challenges and new research avenues for reducing chronic adipose inflammation during HIV/SIV infection is presented.
authors.affiliation: Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1580 NW 10th Avenue BCRI 708, Miami, FL 33136, USA.
authors.forename: Suresh
authors.initials: S
authors.lastname: Pallikkuth
authors.affiliation: Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA. Electronic address: mmohan@tulane.edu.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Mohan
mesh_terms: D000273:Adipose Tissue / Q000276:immunology* / Q000473:pathology / Q000821:virology; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000821:virology; D006678:HIV / Q000235:genetics / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D006801:Humans; D007249:Inflammation / Q000821:virology; D008253:Macaca mulatta / Q000821:virology; D008264:Macrophages / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D019562:Viral Load; D014779:Virus Replication
keywords: CD4/CD8 T-cell; HIV/SIV reservoir; adipose tissue; inflammation; macrophage