title: Semi-automated production of ⁸⁹Zr-oxalate/⁸⁹Zr-chloride and the potential of ⁸⁹Zr-chloride in radiopharmaceutical compounding.
abstract: Interest in using (89)Zr is rapidly increasing for immuno-PET applications due to its unique characteristics and increased availability. The focus of this study was to develop an optimized semi-automated methodology for producing (89)Zr-oxalate/(89)Zr-chloride, and evaluate the potential application of (89)Zr-chloride for radiopharmaceutical compounding. The data presented herein will be useful for the production of (89)Zr-labeled radiopharmaceuticals and their compliance with regulatory issues for both preclinical and clinical use.
authors.affiliation: Cyclotron Radiochemistry Facility, Center for Advanced Biomedical Imaging, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: Mai
authors.initials: M
authors.lastname: Lin
authors.affiliation: Cyclotron Radiochemistry Facility, Center for Advanced Biomedical Imaging, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: Uday
authors.initials: U
authors.lastname: Mukhopadhyay
authors.affiliation: Cyclotron Radiochemistry Facility, Center for Advanced Biomedical Imaging, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Waligorski
authors.affiliation: Cyclotron Radiochemistry Facility, Center for Advanced Biomedical Imaging, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: Julius A
authors.initials: JA
authors.lastname: Balatoni
authors.affiliation: Cyclotron Radiochemistry Facility, Center for Advanced Biomedical Imaging, The University of Texas MD Anderson Cancer Center, Houston, USA; Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address: CEGonzalez1@mdanderson.org.
authors.forename: Carlos
authors.initials: C
authors.lastname: González-Lepera
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods; D002712:Chlorides / Q000302:isolation & purification; D017357:Cyclotrons; D003676:Deferoxamine; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification; D007553:Isotope Labeling / Q000295:instrumentation / Q000379:methods*; D010070:Oxalates / Q000302:isolation & purification; D049268:Positron-Emission Tomography; D011868:Radioisotopes / Q000302:isolation & purification*; D019275:Radiopharmaceuticals / Q000302:isolation & purification*; D052616:Solid Phase Extraction; D015040:Zirconium / Q000302:isolation & purification*
chemical_list: D002712:Chlorides; D007074:Immunoglobulin G; D010070:Oxalates; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D015040:Zirconium; D003676:Deferoxamine; C429984:zirconium chloride
keywords: (89)Zr; DFO; PET; Radiopharmaceutical compounding; Remote synthesis module; Semi-automation