title: Total Synthesis of Linckosides A and B, the Representative Starfish Polyhydroxysteroid Glycosides with Neuritogenic Activities.
abstract: Linckosides A and B, two starfish metabolites with promising neuritogenic activities, are synthesized in a longest linear sequence of 32 steps and 0.5% overall yield; this represents the first synthesis of members of the polyhydroxysteroid glycoside family, which occur widely in starfishes.
authors.affiliation: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D000818:Animals; D016501:Neurites / Q000187:drug effects*; D012503:Saponins / Q000138:chemical synthesis* / Q000494:pharmacology*; D013215:Starfish / Q000737:chemistry
chemical_list: D012503:Saponins; C470915:linckoside A; C470916:linckoside B