title: Radionuclide Assessment of Left Ventricular Dyssynchrony.
abstract: Phase analysis of gated myocardial perfusion single-photon emission computed tomography is a widely available and reproducible measure of left ventricular (LV) dyssynchrony, which also provides comprehensive assessment of LV function, global and regional scar burden, and patterns of LV mechanical activation. Preliminary studies indicate potential use in predicting cardiac resynchronization therapy response and elucidation of mechanisms. Because advances in technology may expand capabilities for precise LV lead placement in the future, identification of specific patterns of dyssynchrony may have a critical role in guiding cardiac resynchronization therapy.
authors.affiliation: Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
authors.forename: Hussein
authors.initials: H
authors.lastname: Abu Daya
authors.affiliation: Division of Cardiology, University at Buffalo, 875 Ellicott Street, Suite 7030, Buffalo, NY 14203, USA.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Malhotra
authors.affiliation: Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address: somanp@upmc.edu.
authors.forename: Prem
authors.initials: P
authors.lastname: Soman
mesh_terms: D057791:Cardiac Imaging Techniques; D058406:Cardiac Resynchronization Therapy; D006801:Humans; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D016277:Ventricular Function, Left
keywords: Cardiac resynchronization therapy; Echo; Heart failure; LBBB; Left ventricular dyssynchrony; Myocardial scar; QRS; Radionuclide; SPECT; Site of latest activation