title: Novel oral anticoagulants and HIV: dabigatran use with antiretrovirals.
abstract: Compatibility of novel oral anticoagulants in patients with HIV taking combined antiretroviral therapy has not been established, with no published reports of successful concurrent use. We present a case where chronic anticoagulation was indicated in a patient with treated HIV and non-valvular atrial fibrillation who refused warfarin therapy. The patient tolerated the combination, with dabigatran blood levels within the expected range at a standard dosing regimen, without evidence of bleeding or other adverse outcomes. While further research is needed to establish the role of novel oral anticoagulants in patients taking antiretrovirals, this case suggests that dabigatran may be a viable option for selected patients.
authors.affiliation: St Vincent's Hospital, Sydney, New South Wales, Australia.
authors.forename: Jacinta
authors.initials: J
authors.lastname: Perram
authors.affiliation: St Vincent's Hospital, Sydney, New South Wales, Australia.
authors.forename: Joanne
authors.initials: J
authors.lastname: Joseph
authors.affiliation: St Vincent's Hospital, Sydney, New South Wales, Australia.
authors.forename: Cameron
authors.initials: C
authors.lastname: Holloway
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000991:Antithrombins / Q000009:adverse effects / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D000075202:Contraindications; D000069604:Dabigatran / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013923:Thromboembolism / Q000517:prevention & control
chemical_list: D019380:Anti-HIV Agents; D000991:Antithrombins; D000069604:Dabigatran