title: Advanced trends in controlling Helicobacter pylori infections using functional and therapeutically supplements in baby milk.
abstract: Helicobacter pylori is a common human pathogen infecting about 30 % of children and 60 % of adults worldwide. It is responsible for diseases such as gastritis, peptic ulcer and gastric cancer. H. pylori treatment based on antibiotics with proton pump inhibitor, but therapy failure is shown to be higher than 20 % and is essentially due to an increasing in prevalence of antibiotic-resistant bacteria, which has led to the search for alternative therapies. In this study, we discuss the usage of natural extracts mixture as alternative or complementary agents in controlling H. pylori infection so here, we focused on the plant extracts of (Cloves, Pepper, Cumin, Sage, Pomegranate peel, Ginger, Myrrh and Licorice). To that end, Phytochemical constituents detection like Tannins, Glycosides, Alkaloids, Flavonoids, Terpenoids, Saponins, Phenolic compounds, Reducing sugars, Volatile oils, Amino acids and Proteins was demonstrated. Each plant extract was examined individually or in combination for its antimicrobial activity against H. pylori. Out of the used extracts, four mixes were prepared and tested against H. pylori. The antibacterial activities of the four mixes, represented by the diameter of inhibition clear zone, recorded 21, 39, 23 and 28 mm. The most potent mix (mix2) was chosen and mixed with baby milk as a new combination for H. pylori infections treatment in babies.
authors.affiliation: Food Technology Department, Arid Land Cultivation Research Institute (ALCRI), City of Scientific Research and Technology Applications (SRTA- CITY), New Borg El-Arab City, Alexandria 21934 Egypt.
authors.forename: Gamal M
authors.initials: GM
authors.lastname: Hamad
authors.affiliation: Environmental Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technology Applications (SRTA- CITY), New Borg El-Arab City, Alexandria 21934 Egypt.
authors.forename: Tarek H
authors.initials: TH
authors.lastname: Taha
authors.affiliation: Bio Pharmaceutical Product Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technology Applications (SRTA- CITY), New Borg El-Arab City, Alexandria 21934 Egypt.
authors.forename: Nehal M
authors.initials: NM
authors.lastname: El-Deeb
authors.affiliation: Biology Department, Faculty of Science, King Khalid University, Abha, 9004 Saudi Arabia.
authors.forename: Ali M A
authors.initials: AM
authors.lastname: Alshehri
keywords: Antimicrobial; Baby milk; Cytotoxicity; Helicobacter pylori; Herbal plants; Phytochmical