title: Impact of morbid obesity and bariatric surgery on antioxidant/oxidant balance of the unstimulated and stimulated human saliva.
abstract: OBJECTIVE
  There is no study evaluating the influence of morbid obesity and bariatric surgery on antioxidant/oxidant homeostasis of the unstimulated and stimulated human saliva.
  
  
  METHODS
  Salivary flow rate, total antioxidant status (TAS), total oxidant status (TOS), oxidative status index (OSI), the total amount of uric acid (UA), polyphenols (pPh), catalase (CAT), superoxide dismutase 2 (SOD2), specific activity of peroxidase (Px), as well as malondialdehyde (MDA), and advanced glycation end products (AGE) concentrations were determined in the unstimulated (UWS) and stimulated (SWS) whole saliva of patients with morbid obesity before and after bariatric surgery.
  
  
  RESULTS
  In both UWS and SWS, the total amount of TOS, OSI, SOD2, and MDA was statistically higher in patients with morbid obesity as compared to the healthy controls, as well as significantly lower in the patients treated surgically as compared to the obese patients. The median values of the total amount of TAS, CAT, UA, pPh, and specific activity of Px were significantly reduced in UWS and SWS in patients with morbid obesity as compared to the control group and also statistically elevated in patients after bariatric surgery as compared to the patients with morbid obesity.
  
  
  CONCLUSIONS
  In morbid obesity, reduced unstimulated and stimulated salivary flow can be observed. Bariatric surgery restored only unstimulated salivary flow to normal values. Disturbances in oxidant/antioxidant homeostasis may be observed in UWS and SWS of obese patients before and after treatment.
authors.affiliation: Institute of Health Care Higher Vocational School, Suwalki, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Knaś
authors.affiliation: Students' Scientific Group ''Stomatological Biochemistry'' at the Department of Conservative Dentistry, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Maciejczyk
authors.affiliation: Department of Conservative Dentistry, Medical University Bialystok, Bialystok, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sawicka
authors.affiliation: 1st Department of General Surgery and Endocrinology, Medical University Bialystok, Bialystok, Poland.
authors.forename: Hady Razak
authors.initials: HR
authors.lastname: Hady
authors.affiliation: Research Laboratory of Esthetic Medicine, Medical University in Bialystok, Bialystok, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Niczyporuk
authors.affiliation: Department of Emergency Medicine and Disaster, Medical University Bialystok, Bialystok, Poland.
authors.forename: Jerzy R
authors.initials: JR
authors.lastname: Ładny
authors.affiliation: County Veterinary Inspection, Bialystok, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Matczuk
authors.affiliation: Department of Conservative Dentistry, Medical University Bialystok, Bialystok, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Waszkiel
authors.affiliation: Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Żendzian-Piotrowska
authors.affiliation: Department of Conservative Dentistry, Medical University Bialystok, Bialystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Zalewska
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D050110:Bariatric Surgery / Q000009:adverse effects / Q000379:methods*; D002374:Catalase / Q000378:metabolism; D004789:Enzyme Activation; D005260:Female; D017127:Glycation End Products, Advanced / Q000032:analysis; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism* / Q000601:surgery*; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D009195:Peroxidase / Q000378:metabolism; D059808:Polyphenols / Q000378:metabolism; D012463:Saliva / Q000378:metabolism*; D012469:Salivary Glands / Q000378:metabolism; D012636:Secretory Rate; D013482:Superoxide Dismutase / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism; D000099156:Superoxide Dismutase 2
chemical_list: D000975:Antioxidants; D002374:Catalase; D017127:Glycation End Products, Advanced; D008315:Malondialdehyde; D016877:Oxidants; D009195:Peroxidase; D059808:Polyphenols; D013482:Superoxide Dismutase; D014527:Uric Acid; D000099156:Superoxide Dismutase 2
keywords: bariatric surgery; human saliva; morbid obesity; oxidative stress; salivary glands