title: Scanning proton beam therapy reduces normal tissue exposure in pelvic radiotherapy for anal cancer.
abstract: An inter-comparison planning study between photon beam therapy (IMRT) and scanning proton beam therapy (SPBT) for squamous cell carcinoma of the anus (SCCA) is presented. SPBT plans offer significant reduction (>50%, P=0.008) in doses to small bowel, and bone marrow thereby offering the potential to reduce bowel and hemotoxicities.
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Phoenix/Scottsdale, United States. Electronic address: anand.aman@mayo.edu.
authors.forename: Aman
authors.initials: A
authors.lastname: Anand
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Phoenix/Scottsdale, United States.
authors.forename: Martin
authors.initials: M
authors.lastname: Bues
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Phoenix/Scottsdale, United States.
authors.forename: William G
authors.initials: WG
authors.lastname: Rule
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Phoenix/Scottsdale, United States.
authors.forename: Sameer R
authors.initials: SR
authors.lastname: Keole
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Rochester, United States.
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Beltran
authors.affiliation: Cancer Center Statistics, Mayo Clinic, Rochester, United States.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Rochester, United States.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Haddock
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Rochester, United States.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Hallemeier
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Jacksonville, United States.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Miller
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Phoenix/Scottsdale, United States.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Ashman
mesh_terms: D000368:Aged; D001005:Anus Neoplasms / Q000532:radiotherapy*; D001853:Bone Marrow / Q000528:radiation effects; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010388:Pelvis / Q000528:radiation effects*; D061766:Proton Therapy; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated
keywords: Anal cancer; Bone marrow sparing; Spot scanning proton planning; Whole pelvis proton therapy