title: The RS685012 Polymorphism of ACCN2, the Human Ortholog of Murine Acid-Sensing Ion Channel (ASIC1) Gene, is Highly Represented in Patients with Panic Disorder.
abstract: Panic disorder (PD) is a disabling anxiety disorder that is characterized by unexpected, recurrent panic attacks, associated with fear of dying and worrying about possible future attacks or other behavioral changes as a consequence of the attacks. The acid-sensing ion channels (ASICs) are a family of proton-sensing channels expressed throughout the nervous system. Their activity is linked to a variety of behaviors including fear, anxiety, pain, depression, learning, and memory. The human analog of ASIC1a is the amiloride-sensitive cation channel 2 (ACCN2). Adenosine A2A receptors are suggested to play an important role in different brain circuits and pathways involved in anxiety reactions. In this work we aimed to evaluate the distribution of ACCN2 rs685012 and ADORA2A rs2298383 polymorphisms in PD patients compared with healthy subjects. We found no association between ADORA2A polymorphism and PD. Instead, the C mutated allele for ACCN2 rs685012 polymorphism was significantly more frequent in patients than in controls. On the contrary, the TT homozygous wild-type genotype and also the ACCN2 TT/ADORA2A CT diplotype were significantly more represented in controls. These results are suggestive for a role of ACCN2 rs685012 polymorphism in PD development in Caucasian people.
authors.affiliation: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Via C. Valeria, 98125, Messina, Italy.
authors.forename: Agnese
authors.initials: A
authors.lastname: Gugliandolo
authors.affiliation: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Via C. Valeria, 98125, Messina, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Gangemi
authors.affiliation: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Via C. Valeria, 98125, Messina, Italy. dcaccamo@unime.it.|MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. dcaccamo@unime.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Caccamo
authors.affiliation: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Via C. Valeria, 98125, Messina, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Currò
authors.affiliation: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Via C. Valeria, 98125, Messina, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Pandolfo
authors.affiliation: MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: Diego
authors.initials: D
authors.lastname: Quattrone
authors.affiliation: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Via C. Valeria, 98125, Messina, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Crucitti
authors.affiliation: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Via C. Valeria, 98125, Messina, Italy.
authors.forename: Rocco Antonio
authors.initials: RA
authors.lastname: Zoccali
authors.affiliation: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Via C. Valeria, 98125, Messina, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Bruno
authors.affiliation: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Via C. Valeria, 98125, Messina, Italy.
authors.forename: Maria Rosaria Anna
authors.initials: MR
authors.lastname: Muscatello
mesh_terms: D062565:Acid Sensing Ion Channels / Q000235:genetics* / Q000502:physiology; D000328:Adult; D000483:Alleles; D000818:Animals; D001923:Brain Chemistry; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D016584:Panic Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D043705:Receptor, Adenosine A2A / Q000235:genetics* / Q000502:physiology; D012802:Sicily; D013045:Species Specificity; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: C568266:ASIC1 protein, human; C568267:ASIC1 protein, mouse; D062565:Acid Sensing Ion Channels; D043705:Receptor, Adenosine A2A
keywords: ACCN2; ADORA2A; Anxiety; Gene polymorphism; Panic disorder