title: Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models.
abstract: Studying long-lived animals provides novel insight into shared characteristics of aging and represents a unique model to elucidate approaches to prevent chronic disease. Oxidant stress underlies many chronic diseases and resistance to stress is a potential mechanism governing slowed aging. The transcription factor nuclear factor (erythroid-derived 2)-like 2 is the "master regulator" of cellular antioxidant defenses. Nrf2 is upregulated by some longevity promoting interventions and may play a role in regulating species longevity. However, Nrf2 expression and activity in long-lived models have not been well described. Here, we review evidence for altered Nrf2 signaling in a variety of slowed aging models that accomplish lifespan extension via pharmacological, nutritional, evolutionary, genetic, and presumably epigenetic means.
authors.affiliation: Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523-1582, USA.
authors.forename: Danielle R
authors.initials: DR
authors.lastname: Bruns
authors.affiliation: Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523-1582, USA.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Drake
authors.affiliation: Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523-1582, USA.
authors.forename: Laurie M
authors.initials: LM
authors.lastname: Biela
authors.affiliation: Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523-1582, USA.
authors.forename: Frederick F
authors.initials: FF
authors.lastname: Peelor
authors.affiliation: Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523-1582, USA.
authors.forename: Benjamin F
authors.initials: BF
authors.lastname: Miller
authors.affiliation: Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523-1582, USA.
authors.forename: Karyn L
authors.initials: KL
authors.lastname: Hamilton
mesh_terms: D000375:Aging; D000818:Animals; D031204:Caloric Restriction; D008136:Longevity; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D051267:NF-E2-Related Factor 2; D013482:Superoxide Dismutase; D016660:NAD(P)H Dehydrogenase (Quinone)