title: Assessment of the best flow model to characterize diffuse correlation spectroscopy data acquired directly on the brain.
abstract: Diffuse correlation spectroscopy (DCS) is a non-invasive optical technique capable of monitoring tissue perfusion. The normalized temporal intensity autocorrelation function generated by DCS is typically characterized by assuming that the movement of erythrocytes can be modeled as a Brownian diffusion-like process instead of by the expected random flow model. Recently, a hybrid model, referred to as the hydrodynamic diffusion model, was proposed, which combines the random and Brownian flow models. The purpose of this study was to investigate the best model to describe autocorrelation functions acquired directly on the brain in order to avoid confounding effects of extracerebral tissues. Data were acquired from 11 pigs during normocapnia and hypocapnia, and flow changes were verified by computed tomography perfusion (CTP). The hydrodynamic diffusion model was found to provide the best fit to the autocorrelation functions; however, no significant difference for relative flow changes measured by the Brownian and hydrodynamic diffusion models was observed.
authors.affiliation: Imaging Division, Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Medical Biophysics, Western University, 1151 Richmond Street North, London, ON N6A 5C1, Canada.
authors.forename: Kyle
authors.initials: K
authors.lastname: Verdecchia
authors.affiliation: Imaging Division, Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Medical Biophysics, Western University, 1151 Richmond Street North, London, ON N6A 5C1, Canada.
authors.forename: Mamadou
authors.initials: M
authors.lastname: Diop
authors.affiliation: Imaging Division, Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Medical Biophysics, Western University, 1151 Richmond Street North, London, ON N6A 5C1, Canada.
authors.forename: Laura B
authors.initials: LB
authors.lastname: Morrison
authors.affiliation: Imaging Division, Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Medical Biophysics, Western University, 1151 Richmond Street North, London, ON N6A 5C1, Canada ; Imaging Research Laboratories, Robarts Research Institute, 1151 Richmond Street North, London, ON N6G 2V4, Canada.
authors.forename: Ting-Yim
authors.initials: TY
authors.lastname: Lee
authors.affiliation: Imaging Division, Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Medical Biophysics, Western University, 1151 Richmond Street North, London, ON N6A 5C1, Canada.
authors.forename: Keith
authors.initials: K
authors.lastname: St Lawrence
keywords: (170.1470) Blood or tissue constituent monitoring; (170.3660) Light propagation in tissues; (170.3880) Medical and biological imaging; (170.6935) Tissue characterization