title: A new flow diverter stent for direct treatment of intracranial aneurysm.
abstract: The use of a stand-alone flow diverter (FD) stent has demonstrated itself as an efficacious endovascular approach to intracranial aneurysm treatment. FD stents that are currently available adopt an interwoven braided design. The relatively low radial stiffness intrinsic to this design could cause difficulty in deployment and poor stent-wall apposition, leading to high complication rates. A new FD stent is proposed to overcome the problems of the interwoven FD stents. The new device is manufactured from a Nitinol tube through a laser-cutting technique, and its unique structure allows for both low porosity and high packaging efficiency. Computational simulation using Abaqus has been conducted to investigate the radial stiffness and longitudinal flexibility of the new device. The new device exhibits high radial stiffness when compared to interwoven FD stents and superior longitudinal flexibility. Results from on-going in-vivo experiments and CFD simulations have also demonstrated the efficacy of the new device as a FD stent.
authors.affiliation: Department of Engineering Science, University of Oxford, UK.
authors.forename: Jiayao
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Engineering Science, University of Oxford, UK. Electronic address: zhong.you@eng.ox.ac.uk.
authors.forename: Zhong
authors.initials: Z
authors.lastname: You
authors.affiliation: Department of Engineering Science, University of Oxford, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Peach
authors.affiliation: Department of Neuroradiology, Nuffield Department of Surgery, University of Oxford, UK.
authors.forename: James
authors.initials: J
authors.lastname: Byrne
authors.affiliation: Department of Neuroradiology, Nuffield Department of Surgery, University of Oxford, UK.
authors.forename: Rafik R
authors.initials: RR
authors.lastname: Rizkallah
mesh_terms: D000497:Alloys / Q000737:chemistry; D000818:Animals; D003198:Computer Simulation; D020342:Finite Element Analysis; D006439:Hemodynamics; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D008422:Materials Testing; D016062:Porosity; D011817:Rabbits; D015607:Stents; D013314:Stress, Mechanical
chemical_list: D000497:Alloys; C013616:nitinol
keywords: Flow diverter stent; Intracranial aneurysm; Longitudinal flexibility; Radial stiffness