title: Smart nanosystems: Bio-inspired technologies that interact with the host environment.
abstract: Nanoparticle technologies intended for human administration must be designed to interact with, and ideally leverage, a living host environment. Here, we describe smart nanosystems classified in two categories: (i) those that sense the host environment and respond and (ii) those that first prime the host environment to interact with engineered nanoparticles. Smart nanosystems have the potential to produce personalized diagnostic and therapeutic schema by using the local environment to drive material behavior and ultimately improve human health.
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;
authors.forename: Ester J
authors.initials: EJ
authors.lastname: Kwon
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139; Medical Scientist Training Program, Harvard Medical School, Boston, MA 02115;
authors.forename: Justin H
authors.initials: JH
authors.lastname: Lo
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115 sbhatia@mit.edu.
authors.forename: Sangeeta N
authors.initials: SN
authors.lastname: Bhatia
mesh_terms: D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D050997:Nanomedicine; D053758:Nanoparticles; D036103:Nanotechnology; D010084:Oxidation-Reduction
keywords: cancer nanotechnology; environment-responsive; host priming; nanosystems; smart nanomaterials