title: Decline of Plasmacytoid Dendritic Cells and Their Subsets in Normal Pregnancy Are Related with Hormones.
abstract: OBJECTIVE
  To analyze the frequency of plasmacytoid dendritic cells (pDCs) in pregnancy, especially their subsets, by flow cytometry in each trimester and in the postpartum period.
  
  
  METHODS
  Peripheral blood was collected from pregnant women in each trimester and from non-pregnant women. Serum hormones were detected by ELISA, while pDCs and their subsets were detected by flow cytometer. Then correlation between them was further analyzed.
  
  
  RESULTS
  Both pDCs and their subsets declined as pregnancy progressed. Further experiments indicate that estradiol and progesterone are significantly negatively correlated with this change.
  
  
  CONCLUSIONS
  Our findings increase the knowledge of pDC subsets in healthy pregnant conditions.
authors.forename: Mingming
authors.initials: M
authors.lastname: Yang
authors.forename: Lingling
authors.initials: L
authors.lastname: Yang
authors.forename: Xiaoye
authors.initials: X
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wei
authors.forename: Yangyu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D049590:Postpartum Period / Q000276:immunology*; D011247:Pregnancy / Q000097:blood / Q000276:immunology*; D011264:Pregnancy Trimesters; D011374:Progesterone / Q000097:blood*; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol