title: Our Odyssey with Functionalized Chiral Phosphines: From Optical Resolution to Asymmetric Synthesis to Catalysis.
abstract: Our journey in organophosphorus research over the past 26 years is compiled in this Personal Account. Advances in palladacycle design have engendered a shift in our focus from template-mediated transformations to catalysis for the direct preparation of chiral phosphines containing a wide variety of functional groups. Novel approaches to access previously inaccessible phosphines and their applications in cancer research are summarized herein.
authors.affiliation: School of Physical and Mathematical Sciences Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.
authors.forename: Renta Jonathan
authors.initials: RJ
authors.lastname: Chew
authors.affiliation: School of Physical and Mathematical Sciences Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.
authors.forename: Pak-Hing
authors.initials: PH
authors.lastname: Leung
keywords: P ligands; asymmetric synthesis; hydrophosphination; metallacycles; palladium