title: A correlation analysis between HDAC1 over-expression and clinical features of laryngeal squamous cell carcinoma.
abstract: CONCLUSIONS
  HDAC1 may be a prognostic biomarker for LSCC malignant potency and a potent factor resulting in decreased sensitivity of LSCC in radiotherapy.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the correlation between histone deacetylase 1 (HDAC1) over-expression and clinical features in laryngeal squamous cell carcinoma (LSCC).
  
  
  METHODS
  This study assessed the HDAC1 expressions in 90 formalin-fixed paraffin-embedded LSCC samples, 30 adjacent non-neoplastic tissues, and 30 laryngeal polyp tissues by immunohistochemistry (IHC). In addition, another 40 LSCC samples were collected that were divided into two groups after 3-month radiotherapy: the high radio-sensitive group (HRS) and low radio-sensitive group (LRS). Overall survival curves of all the LSCC patients were constructed by Kaplan-Meier method and long-rank test.
  
  
  RESULTS
  All ninety samples were positively immunostained for HDAC1. The expression of HDAC1 was up-regulated and significantly associated with T classification, lymph node metastases, tumor location and clinical stage. HDAC1 was mainly labeled in the epithelial cells of laryngeal polyp tissues and adjacent non-neoplastic tissues. In addition, the expression of HDAC1 was significantly higher in LRS than that in HRS. The positive rates for stage III-IV tumor were significantly higher than those for stage II. LSCC patients with HDAC1 over-expression and LRS presented a shorter 5-year overall survival rate.
authors.affiliation: a Department of Otorhinolaryngology, Head and Neck Surgery , The Second Affiliated Hospital of Harbin Medical University , Harbin , PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
authors.affiliation: a Department of Otorhinolaryngology, Head and Neck Surgery , The Second Affiliated Hospital of Harbin Medical University , Harbin , PR China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Chen
authors.affiliation: a Department of Otorhinolaryngology, Head and Neck Surgery , The Second Affiliated Hospital of Harbin Medical University , Harbin , PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Cao
authors.affiliation: a Department of Otorhinolaryngology, Head and Neck Surgery , The Second Affiliated Hospital of Harbin Medical University , Harbin , PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.affiliation: a Department of Otorhinolaryngology, Head and Neck Surgery , The Second Affiliated Hospital of Harbin Medical University , Harbin , PR China.
authors.forename: Linli
authors.initials: L
authors.lastname: Tian
authors.affiliation: a Department of Otorhinolaryngology, Head and Neck Surgery , The Second Affiliated Hospital of Harbin Medical University , Harbin , PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D056284:Histone Deacetylase 1 / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C110550:HDAC1 protein, human; D056284:Histone Deacetylase 1
keywords: HDAC1; LSCC; laryngeal polyp; radio-sensitivity