title: Pediatric invasive pneumococcal disease in Senegal.
abstract: OBJECTIVE
  We aimed to describe the clinical, epidemiological, and outcome characteristics of IPD case patients hospitalized at the Albert-Royer National Children's Hospital (French acronym CHNEAR) to evaluate the disease burden of IPDs in a pediatric hospital of Dakar (Senegal).
  
  
  METHODS
  All children aged 0-15 years hospitalized at the CHNEAR between January 1st, 2008 and December 31st, 2013 for a documented IPD were included in the study. Medical history, risk factors, clinical, bacteriological, and outcome data was collected. Data was then analyzed using the SPSS software, version 16 (Pearson's Chi(2) test: a P-value<0.05 was considered statistically significant).
  
  
  RESULTS
  A total of 218 IPD patients were hospitalized at the CHNEAR during the study period (hospital prevalence: 0.79%). The mean age was 36.1 months. The male to female ratio was 1.27 (122 boys and 96 girls). Infants<2 years of age represented 61.46% of patients. Prior antibiotic therapy was found in 54% of patients but details were lacking. Infection sites were mostly meningeal (61%) and pleuropulmonary (28.9%). The main isolated serotypes were 1, 6A, 14, 5, and 23F. Case fatality was 17.4% and it was five times higher for pneumococcal meningitis.
  
  
  CONCLUSIONS
  IPDs are very common in children in Senegal. Infants<2 years of age are particularly affected. The very high case fatality (17%) was significantly associated with meningeal infection sites hence the need for better access to pneumococcal vaccines.
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal. Electronic address: docteuridy@hotmail.com.
authors.forename: I D
authors.initials: ID
authors.lastname: Ba
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: A
authors.initials: A
authors.lastname: Ba
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: P M
authors.initials: PM
authors.lastname: Faye
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: A
authors.initials: A
authors.lastname: Thiongane
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: M
authors.initials: M
authors.lastname: Attiyé Kane
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: A
authors.initials: A
authors.lastname: Sonko
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: A
authors.initials: A
authors.lastname: Diop
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: I
authors.initials: I
authors.lastname: Deme Ly
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: F N
authors.initials: FN
authors.lastname: Diouf
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: O
authors.initials: O
authors.lastname: Ndiaye
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: M M M
authors.initials: MM
authors.lastname: Leye
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: M F
authors.initials: MF
authors.lastname: Cissé
authors.affiliation: Hôpital d'enfants Albert-Royer de Fann-Dakar, université Cheikh Anta Diop de Dakar, BP 16109, Fann, Dakar, Senegal.
authors.forename: M
authors.initials: M
authors.lastname: Ba
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011008:Pneumococcal Infections / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D012675:Senegal / Q000453:epidemiology
keywords: Infections invasives à pneumocoque; Invasive pneumococcal disease; Pediatrics; Pneumococci with reduced susceptibility to penicillin; Pneumocoque à sensibilité diminuée à la pénicilline; Pédiatrie; Senegal; Sénégal