title: Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity.
abstract: Synaptic adhesion molecules regulate synapse development and plasticity through mechanisms that include trans-synaptic adhesion and recruitment of diverse synaptic proteins. We found that the immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially expressed in the brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors (AMPARs). IgSF11 required PSD-95 binding for its excitatory synaptic localization. In addition, IgSF11 stabilized synaptic AMPARs, as determined by IgSF11 knockdown-induced suppression of AMPAR-mediated synaptic transmission and increased surface mobility of AMPARs, measured by high-throughput, single-molecule tracking. IgSF11 deletion in mice led to the suppression of AMPAR-mediated synaptic transmission in the dentate gyrus and long-term potentiation in the CA1 region of the hippocampus. IgSF11 did not regulate the functional characteristics of AMPARs, including desensitization, deactivation or recovery. These results suggest that IgSF11 regulates excitatory synaptic transmission and plasticity through its tripartite interactions with PSD-95 and AMPARs.
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
authors.forename: Seil
authors.initials: S
authors.lastname: Jang
authors.affiliation: Department of Biomedical Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.|Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seoul, Korea.
authors.forename: Daeyoung
authors.initials: D
authors.lastname: Oh
authors.affiliation: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 305-701, Korea.
authors.forename: Yeunkum
authors.initials: Y
authors.lastname: Lee
authors.affiliation: University of Bordeaux, Interdisciplinary Institute for Neuroscience, France; CNRS UMR 5297, F-33000 Bordeaux, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Hosy
authors.affiliation: Department of Biomedical Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
authors.forename: Hyewon
authors.initials: H
authors.lastname: Shin
authors.affiliation: Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D-37075 Göttingen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: van Riesen
authors.affiliation: School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Whitson street, Bristol, UK.|Centre for Synaptic Plasticity, University of Bristol, Whitson street, Bristol, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Whitcomb
authors.affiliation: School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Whitson street, Bristol, UK.
authors.forename: Julia M
authors.initials: JM
authors.lastname: Warburton
authors.affiliation: School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Whitson street, Bristol, UK.|Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Jo
authors.affiliation: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 305-701, Korea.
authors.forename: Doyoun
authors.initials: D
authors.lastname: Kim
authors.affiliation: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 305-701, Korea.
authors.forename: Sun Gyun
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
authors.forename: Seung Min
authors.initials: SM
authors.lastname: Um
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
authors.forename: Seok-Kyu
authors.initials: SK
authors.lastname: Kwon
authors.affiliation: Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.|Seoul National University Bundang Hospital, Seongnam, Gyeonggi 463-707, Republic of Korea.
authors.forename: Myoung-Hwan
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 305-701, Korea.
authors.forename: Junyeop Daniel
authors.initials: JD
authors.lastname: Roh
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
authors.forename: Jooyeon
authors.initials: J
authors.lastname: Woo
authors.affiliation: Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
authors.forename: Heejung
authors.initials: H
authors.lastname: Jun
authors.affiliation: Department of Anatomy and Division of Brain Korea 21 Biomedical Science, College of Medicine, Korea University, 126-1, 5-Ka, Anam-Dong, Seongbuk-Gu, Seoul 136-705, Korea.
authors.forename: Dongmin
authors.initials: D
authors.lastname: Lee
authors.affiliation: Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 700-412, Korea.
authors.forename: Won
authors.initials: W
authors.lastname: Mah
authors.affiliation: Department of Anatomy and Division of Brain Korea 21 Biomedical Science, College of Medicine, Korea University, 126-1, 5-Ka, Anam-Dong, Seongbuk-Gu, Seoul 136-705, Korea.
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
authors.affiliation: Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
authors.affiliation: School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Whitson street, Bristol, UK.|Centre for Synaptic Plasticity, University of Bristol, Whitson street, Bristol, UK.
authors.forename: Kwangwook
authors.initials: K
authors.lastname: Cho
authors.affiliation: Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D-37075 Göttingen, Germany.
authors.forename: Jeong-Seop
authors.initials: JS
authors.lastname: Rhee
authors.affiliation: University of Bordeaux, Interdisciplinary Institute for Neuroscience, France; CNRS UMR 5297, F-33000 Bordeaux, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Choquet
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.|Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 305-701, Korea.
authors.forename: Eunjoon
authors.initials: E
authors.lastname: Kim
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism / Q000502:physiology*; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D002478:Cells, Cultured; D000076122:Disks Large Homolog 4 Protein; D005786:Gene Expression Regulation / Q000502:physiology*; D055785:Gene Knockdown Techniques; D006168:Guinea Pigs; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D018408:Patch-Clamp Techniques; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules; D015816:Cell Adhesion Molecules, Neuronal; D000076122:Disks Large Homolog 4 Protein; C501449:Dlg4 protein, rat; C482101:IGSF11 protein, human; D007136:Immunoglobulins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D018091:Receptors, AMPA