title: Peculiar Effects of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiac Chronotropy in Newborn Rats.
abstract: We studied the effects of selective blockade of various subtypes of α2-adrenoceptors on cardiac chronotropy in newborn rats. This period in rats is characterized by the absence of adrenergic regulation of heart function. Blockade of α2A/D- and α2B-adrenoceptors in 1-weekold rats provoked tachycardia. In contrast, blockade of α2C-adrenoceptors in newborn rats had no effect on heart rate.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia. zefirovtl@mail.ru.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Khisamieva
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Ziyatdinova
authors.affiliation: Department of Normal Physiology, Kazan Federal Medical University, Kazan, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D000166:Acridines / Q000494:pharmacology; D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D006321:Heart / Q000254:growth & development; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D019329:Idazoxan / Q000031:analogs & derivatives / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology*; D017661:Receptors, Presynaptic / Q000502:physiology*; D013610:Tachycardia / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D000166:Acridines; D058669:Adrenergic alpha-2 Receptor Antagonists; D007093:Imidazoles; C518829:JP-1302; D010879:Piperazines; D018341:Receptors, Adrenergic, alpha-2; D017661:Receptors, Presynaptic; C058525:2-methoxyidazoxan; D019329:Idazoxan; C044484:Imiloxan
keywords: chronotropy; heart; ontogeny; rats; α2-adrenoceptors