title: Hyaluronic acid for anticancer drug and nucleic acid delivery.
abstract: Hyaluronic acid (HA) is widely used in anticancer drug delivery, since it is biocompatible, biodegradable, non-toxic, and non-immunogenic; moreover, HA receptors are overexpressed on many tumor cells. Exploiting this ligand-receptor interaction, the use of HA is now a rapidly-growing platform for targeting CD44-overexpressing cells, to improve anticancer therapies. The rationale underlying approaches, chemical strategies, and recent advances in the use of HA to design drug carriers for delivering anticancer agents, are reviewed. Comprehensive descriptions are given of HA-based drug conjugates, particulate carriers (micelles, liposomes, nanoparticles, microparticles), inorganic nanostructures, and hydrogels, with particular emphasis on reports of preclinical/clinical results.
authors.affiliation: Università degli Studi di Torino, Dipartimento di Scienza e Tecnologia del Farmaco, v. P. Giuria 9, 10125 Torino, Italy. Electronic address: franco.dosio@unito.it.
authors.forename: Franco
authors.initials: F
authors.lastname: Dosio
authors.affiliation: Università degli Studi di Torino, Dipartimento di Scienza e Tecnologia del Farmaco, v. P. Giuria 9, 10125 Torino, Italy. Electronic address: silvia.arpicco@unito.it.
authors.forename: Silvia
authors.initials: S
authors.lastname: Arpicco
authors.affiliation: Università degli Studi di Torino, Dipartimento di Scienza e Tecnologia del Farmaco, v. P. Giuria 9, 10125 Torino, Italy. Electronic address: barbara.stella@unito.it.
authors.forename: Barbara
authors.initials: B
authors.lastname: Stella
authors.affiliation: Université Paris-Sud, Faculté de Pharmacie, Institut Galien Paris-Sud, LabEx LERMIT, 5 rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France; CNRS, UMR 8612, 5 rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France. Electronic address: elias.fattal@u-psud.fr.
authors.forename: Elias
authors.initials: E
authors.lastname: Fattal
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000737:chemistry; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry; D009696:Nucleic Acids / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005079:Excipients; D020100:Hydrogels; D009696:Nucleic Acids; D006820:Hyaluronic Acid
keywords: Anticancer agents; CD44; Conjugates; Drug delivery systems; Hyaluronic acid; Nanotechnology