title: Synthesis, crystal structure, DNA and protein binding studies of novel binuclear Pd(II) complex of 6-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicarbazone.
abstract: A novel binuclear palladium(II) complex [(AsPh3)2ClPd(L)PdCl] (LPd2) has been synthesized by reacting 2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicarbazone (HL) with [PdCl2(AsPh3)2], and the molecular structure was confirmed by single crystal X-ray diffraction studies. The DNA interactions of the free ligand and of the complex have been evaluated by absorption and ethidium bromide (EB) competitive studies which revealed that the complex could interact with calf thymus DNA (CT-DNA) through intercalation. In addition, the interactions with bovine serum albumin (BSA) were also studied showing that the new binuclear palladium complex had a strong binding affinity with BSA.
authors.affiliation: Department of Industrial Engineering, University Of Padova, Padova 35131, Italy.
authors.forename: Ramachandran
authors.initials: R
authors.lastname: Eswaran
authors.affiliation: Department of Industrial Engineering, University Of Padova, Padova 35131, Italy. Electronic address: roberta.bertani@unipd.it.
authors.forename: Roberta
authors.initials: R
authors.lastname: Bertani
authors.affiliation: Department of Industrial Engineering, University Of Padova, Padova 35131, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Sgarbossa
authors.affiliation: Department of Chemistry, Bharathiar University, Coimbatore 641046, Tamil Nadu, India. Electronic address: k_natraj6@yahoo.com.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Karuppannan
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, TX 77842, USA.
authors.forename: Bhuvanesh
authors.initials: B
authors.lastname: Nattamai S P
mesh_terms: D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D011506:Proteins; D013882:Thiosemicarbazones; D010165:Palladium; D004247:DNA
keywords: BSA binding; Binuclear palladium(II) complex; DNA binding; Quinoline; Thiosemicarbazone