title: Pharmacological perspectives in sarcopenia: a potential role for renin-angiotensin system blockers?
abstract: Sarcopenia represents a major health problem highly prevalent in elderly and age-related chronic diseases. Current pharmacological strategies available to prevent and reverse sarcopenia are largely unsatisfactory thus raising the need to identify novel targets for pharmacological intervention and possibly more effective and safe drugs. This review highlights the current knowledge of the potential benefits of renin-angiotensin system blockade in sarcopenia and discuss the main mechanisms underlying the effects.
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Center of Molecular Medicine (CIMMBA), University of Florence, Florence, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Sartiani
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Center of Molecular Medicine (CIMMBA), University of Florence, Florence, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Spinelli
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Center of Molecular Medicine (CIMMBA), University of Florence, Florence, Italy.
authors.forename: Annunziatina
authors.initials: A
authors.lastname: Laurino
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Center of Molecular Medicine (CIMMBA), University of Florence, Florence, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Blescia
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Center of Molecular Medicine (CIMMBA), University of Florence, Florence, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Raimondi
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Center of Molecular Medicine (CIMMBA), University of Florence, Florence, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Cerbai
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Center of Molecular Medicine (CIMMBA), University of Florence, Florence, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mugelli
keywords: angiotensin; angiotensin receptors blockers; angiotensin-converting enzyme inhibitors; sarcopenia; skeletal muscle