title: High-risk human papillomavirus cervical infections among healthy women in Guadeloupe.
abstract: OBJECTIVE
  To assess high-risk human papillomavirus (HR HPV) cervical infections and their type distribution among healthy women in Guadeloupe, French West Indies.
  
  
  METHODS
  The details of consecutive non-pregnant women who attended cervical cancer screening and had HPV genotyping performed at the largest pathology laboratory on the island from January 1, 2013 to December 31, 2014 were recorded retrospectively. All women with available HPV genotyping results were included in the study.
  
  
  RESULTS
  HR HPV genotyping results for 618 women (median age 42 years) were collected. The overall prevalence rate of HR HPV cervical infection was 36.1% (95% confidence interval (CI) 32.3-40.0%), with the following type distribution: HPV 16 or 18 irrespective of other HPV types, 7.3% (95% CI 5.4-9.6%); other HR HPV types excluding HPV 16 or 18, 28.8% (95% CI 25.3-32.5%). The prevalence rates of overall HR HPV and HR HPV other than 16 or 18 infection increased significantly (p<0.001) with the severity of cytology grade, from 19.7% for normal cytology to 53.8% in atypical squamous cells of undetermined significance (ASC-US) and 67.7% in low-grade squamous intraepithelial lesions (LSIL).
  
  
  CONCLUSIONS
  The high prevalence rate of HR HPV cervical infection with genotypes other than 16 and 18 in Guadeloupe, irrespective of age and the cytology grade, suggests a potential benefit of the new nine-valent HPV vaccine to prevent HPV infection-related cancers in this Caribbean country.
authors.affiliation: Dermatology and Internal Medicine Unit, Guadeloupe University Hospital and EA 4546, CELTEC, Antilles University, BP 465, 97159 Pointe-à-Pitre cedex, Guadeloupe. Electronic address: nadege.cordel@chu-guadeloupe.fr.
authors.forename: Nadège
authors.initials: N
authors.lastname: Cordel
authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center, Temple Health and Department of Epidemiology and Biostatistics, Temple University, College of Public Health, Philadelphia, Pennsylvania, USA.
authors.forename: Camille
authors.initials: C
authors.lastname: Ragin
authors.affiliation: Pathology Laboratory Trival Monique, Jarry, Guadeloupe.
authors.forename: Monique
authors.initials: M
authors.lastname: Trival
authors.affiliation: Centre d'Investigation Clinique Antilles-Guyane, Guadeloupe, Inserm CIC 1424.
authors.forename: Benoît
authors.initials: B
authors.lastname: Tressières
authors.affiliation: Parent-Child Department, Gynecology and Obstetrics Unit, Guadeloupe University Hospital, EA 4546, CELTEC, Antilles University, Guadeloupe.
authors.forename: Eustase
authors.initials: E
authors.lastname: Janky
mesh_terms: D000328:Adult; D055088:Early Detection of Cancer; D005260:Female; D005838:Genotype; D019430:Guadeloupe / Q000453:epidemiology; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D006801:Humans; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology*
keywords: Caribbean; Cervical infection; Cytology; High-risk human papillomavirus; Prevalence