title: The wonderous chaperones: A highlight on therapeutics of cancer and potentially malignant disorders.
abstract: Diverse environmental and physiological factors are known to induce the transcription of a set of genes encoding special protective molecules known as "molecular chaperones" within our cells. Literature abounds in evidence regarding the varied roles; these "guides" can effectively perform in our system. Highly conserved through evolution, from the prokaryotes to the eukaryotes, these make perfect study tools for verifying their role in both the pathogenesis as well as the therapeutics of varied neurodegenerative, autoimmune and potentially malignant disorders and varied cancer states. We present a concise review of this ever dynamic molecule, highlighting the probable role in a potentially malignant disorder, oral lichen planus.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Institute of Dental Studies and Technologies, NH-58, Kadrabad, Modinagar, New Delhi, India.
authors.forename: Nutan
authors.initials: N
authors.lastname: Tyagi
authors.affiliation: Department of Pedodontics and Preventive Dentistry, University of Delhi, University College of Medical Sciences and GTB Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Rishi
authors.initials: R
authors.lastname: Tyagi
keywords: Cancer therapeutics; cytoprotection; heat shock response; molecular chaperones