title: Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity.
abstract: Premature infants suffer significant respiratory morbidity during infancy with long-term negative consequences on health, quality of life, and health care costs. Enhanced susceptibility to a variety of infections and inflammation play a large role in early and prolonged lung disease following premature birth, although the mechanisms of susceptibility and immune dysregulation are active areas of research. This article reviews aspects of host-pathogen interactions and immune responses that are altered by preterm birth and that impact chronic respiratory morbidity in these children.
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY 14642, USA; Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA. Electronic address: gloria_pryhuber@urmc.rochester.edu.
authors.forename: Gloria S
authors.initials: GS
authors.lastname: Pryhuber
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000276:immunology*; D002821:Chorioamnionitis / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007249:Inflammation; D008168:Lung / Q000276:immunology*; D011014:Pneumonia / Q000276:immunology*; D011247:Pregnancy; D011788:Quality of Life; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology*
keywords: Bronchopulmonary dysplasia; Chronic lung disease of prematurity; Lymphocytes; Neonatal immunology; Neonatal infection; Prematurity; Preterm; Virus