title: Acute myeloid leucaemia presenting as a rapidly progressive polyradiculoneuropathy.
abstract: Neurological involvement at onset in acute myeloid leucaemia (AML) is rare, with only a few isolated case reports. We present the case of a 46-year-old man with rapidly progressive polyradiculoneuropathy as the presenting feature of AML. The proposed mechanism for this is postulated to be direct intraneural infiltration, although a paraneoplastic, autoimmune-related phenomenon could be possible. Despite chemotherapeutic intervention, the patient died 1 month after initial presentation. Although rare, neurological manifestations of AML do occur and it is important to include haematological malignancies in the differential diagnosis in patients presenting with neurological symptoms.
authors.affiliation: Department of Neurology, Morriston Hospital, Swansea, UK.
authors.forename: Claire L
authors.initials: CL
authors.lastname: Hirst
authors.affiliation: Department of Neurology, University Hospital of Wales, Cardiff, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Willis
authors.affiliation: Department of Neurology, Morriston Hospital, Swansea, UK.
authors.forename: Hussain
authors.initials: H
authors.lastname: Hussain
authors.affiliation: Department of Neurology, Morriston Hospital, Swansea, UK.
authors.forename: Rob
authors.initials: R
authors.lastname: Powell
mesh_terms: D017809:Fatal Outcome; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000209:etiology*