title: Assessment of relative bioavailability of heavy metals in soil using in vivo mouse model and its implication for risk assessment compared with bioaccessibility using in vitro assay.
abstract: There is limited study to simultaneously determine the relative bioavailability of heavy metals such as Cd, Pb, Cu, Cr(VI), and Ni in soil samples. In the present study, the bioaccessibility of heavy metals using in vitro assay was compared with the relative bioavailability of heavy metals using in vivo mouse model. The bioaccessibility of heavy metals ranged from 9.05 ± 0.97 % (Cr) to 42.8 ± 3.52 % (Cd). The uptake profile of heavy metals in soil and solution samples in mouse revealed that the uptake kinetics could be fitted to a two-compartment model. The relative bioavailability of heavy meals ranged from 34.8 ± 7.0 % (Ni) to 131 ± 20.3 % (Cu). Poor correlation between bioaccessibility and relative bioavailability of heavy metals was observed (r (2) = 0.11, p > 0.05). The relative bioavailability of heavy metals was significantly higher than the bioaccessibility of heavy metals (p < 0.05). The present study indicated that the in vitro digestion method should be carefully employed in risk assessment.
authors.affiliation: Guangdong Engineering Technology Research Center for Drinking Water Safety; School of Chemistry and Environment, South China Normal University, Higher Education Mega Center, Guangzhou, 510006, People's Republic of China. kangyuan@m.scnu.edu.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Kang
authors.affiliation: Guangdong Engineering Technology Research Center for Drinking Water Safety; School of Chemistry and Environment, South China Normal University, Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Pan
authors.affiliation: Guangdong Engineering Technology Research Center for Drinking Water Safety; School of Chemistry and Environment, South China Normal University, Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.
authors.forename: Siyun
authors.initials: S
authors.lastname: Liang
authors.affiliation: Guangdong Engineering Technology Research Center for Drinking Water Safety; School of Chemistry and Environment, South China Normal University, Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Guangdong Engineering Technology Research Center for Drinking Water Safety; School of Chemistry and Environment, South China Normal University, Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.
authors.forename: Lixuan
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Guangdong Engineering Technology Research Center for Drinking Water Safety; School of Chemistry and Environment, South China Normal University, Higher Education Mega Center, Guangzhou, 510006, People's Republic of China. hnsdhks@163.com.
authors.forename: Qiuyun
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Guangdong Engineering Technology Research Center for Drinking Water Safety; School of Chemistry and Environment, South China Normal University, Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.
authors.forename: Jiwen
authors.initials: J
authors.lastname: Luo
mesh_terms: D000818:Animals; D001682:Biological Availability; D066298:In Vitro Techniques; D008297:Male; D019216:Metals, Heavy / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D018570:Risk Assessment / Q000379:methods; D012987:Soil / Q000737:chemistry; D012989:Soil Pollutants / Q000737:chemistry / Q000378:metabolism*
chemical_list: D019216:Metals, Heavy; D012987:Soil; D012989:Soil Pollutants
keywords: Bioaccessibility; Heavy metals; Relative bioavailability