title: Autophagy as a Potential Target for Sarcopenia.
abstract: Sarcopenia is an aging-related disease with a significant reduction in mass and strength of skeletal muscle due to the imbalance between protein synthesis and protein degradation. The loss of skeletal muscle is an inevitable event during aging process, which can result in the significant impact on the quality of life, and also can increase the risk for other aging-associated diseases in the elderly. However, the underlying molecular mechanism of aging-related skeletal muscle loss is still poorly understood. Autophagy is a degradation pathway for the clearance of dysfunctional organelles and damaged macromolecules during aging process. Appropriate induction or accurate regulation of autophagic process and improved quality control of mitochondria through autophagy or other strategies are required for the maintenance of skeletal muscle mass. In this article, we have summarized the current understanding of autophagic pathways in sarcopenia, and discussed the functional status of autophagy and autophagy-associated quality control of mitochondria in the pathogenesis of sarcopenia. Moreover, this article will provide some theoretical references for the exploration of scientific and optimal intervention strategies such as exercise and caloric restriction for the prevention and treatment of sarcopenia through the regulation of autophagic pathways.
authors.affiliation: College of Health Science, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, Wuhan Sports University, Wuhan, China.|Hubei Exercise Training and Monitoring Key Laboratory, Wuhan Sports University, Wuhan, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Fan
authors.affiliation: College of Health Science, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, Wuhan Sports University, Wuhan, China.|Hubei Exercise Training and Monitoring Key Laboratory, Wuhan Sports University, Wuhan, China.
authors.forename: Xianjuan
authors.initials: X
authors.lastname: Kou
authors.affiliation: College of Health Science, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, Wuhan Sports University, Wuhan, China.|Hubei Exercise Training and Monitoring Key Laboratory, Wuhan Sports University, Wuhan, China.
authors.forename: Shaohui
authors.initials: S
authors.lastname: Jia
authors.affiliation: Graduate School, Wuhan Sports University, Wuhan, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Hubei Exercise Training and Monitoring Key Laboratory, Wuhan Sports University, Wuhan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: College of Health Science, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, Wuhan Sports University, Wuhan, China.|Hubei Exercise Training and Monitoring Key Laboratory, Wuhan Sports University, Wuhan, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics* / Q000473:pathology; D001343:Autophagy / Q000235:genetics*; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology; D055948:Sarcopenia / Q000235:genetics* / Q000473:pathology