title: Pd-Catalyzed Isocyanide Assisted Reductive Cyclization of 1-(2-Hydroxyphenyl)-propargyl Alcohols for 2-Alkyl/Benzyl Benzofurans and Their Useful Oxidative Derivatization.
abstract: An unusual Pd-catalyzed isocyanide assisted 5-exo-dig reductive cyclization of 1-(2-hydroxyphenyl)-propargyl alcohols is achieved for 2-alkyl/benzyl benzofurans. The reaction features a high substrate scope, insensitivity to air, and excellent product yielding. Further, a direct metal-free C-H functionalization (azidation, alkoxylation, and hydroxylation) and selective oxidative cleavage of thus synthesized 2-benzylfurans are described for azido-, alkoxy-, hydroxyl-, amide-, and tetrazolyl adducts.
authors.affiliation: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute , BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India.
authors.forename: Manda
authors.initials: M
authors.lastname: Rajesh
authors.affiliation: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute , BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India.
authors.forename: Nuligonda
authors.initials: N
authors.lastname: Thirupathi
authors.affiliation: SAIF Division, CSIR-CDRI , Lucknow 226031, India.
authors.forename: Thota Jagadeshwar
authors.initials: TJ
authors.lastname: Reddy
authors.affiliation: SAIF Division, CSIR-CDRI , Lucknow 226031, India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kanojiya
authors.affiliation: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute , BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India.|Academy of Scientific and Innovative Research , New Delhi 110001, India.
authors.forename: Maddi Sridhar
authors.initials: MS
authors.lastname: Reddy