title: Association between MYC rs9642880[T] allele and bladder cancer risk: a meta-analysis.
abstract: A single nucleotide polymorphism of MYC rs9642880 (G>T) at the 8q24.1 locus is thought to be associated with bladder cancer risk based on the results of genome-wide association studies, but the results remain inconclusive. To assess the association between rs9642880[T] allele and bladder cancer risk, we performed this meta-analysis including 18 case-control studies and involving 23,084 cases and 97,164 controls. Electronic searches for publications were conducted to determine the association between this variant and prostate cancer in several databases. The last search update was August 4, 2014. We used odds ratios and 95%CIs to evaluate the strength of the associations. The overall results suggested that the rs9642880[T] allele was associated with bladder cancer susceptibility (T vs G, odds ratio = 1.18, 95%CI = 1.14-1.22). In subgroup analysis by ethnicity and source of controls, the risk remained significant. The present meta-analysis suggests that the MYC rs9642880[T] allele is significantly associated with bladder cancer risk.
authors.affiliation: Department of Urology, Xuzhou Cancer Hospital, Affiliated Hospital of Jiangsu University, Jiangsu, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Urology, Xuzhou Cancer Hospital, Affiliated Hospital of Jiangsu University, Jiangsu, China.
authors.forename: J G
authors.initials: JG
authors.lastname: Qi
authors.affiliation: Department of Urology, Xuzhou Cancer Hospital, Affiliated Hospital of Jiangsu University, Jiangsu, China.
authors.forename: N
authors.initials: N
authors.lastname: Yang
authors.affiliation: Department of Urology, Xuzhou Cancer Hospital, Affiliated Hospital of Jiangsu University, Jiangsu, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Lin
authors.affiliation: Department of Urology, Xuzhou Cancer Hospital, Affiliated Hospital of Jiangsu University, Jiangsu, China.
authors.forename: J
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of General Surgery, The East District of Suzhou Municipal Hospital, Suzhou, China 601127797@qq.com.
authors.forename: X
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc