title: The radiolytic studies of cefpirome sulfate in the solid state.
abstract: The possibility of applying radiation sterilization to cefpirome sulfate was investigated. The lack of changes in the chemical structure of cefpirome sulfate irradiated with a dose of 25 kGy, required to attain sterility, was confirmed by UV, FT-IR, Raman, DSC and chromatographic methods. Some radical defects with concentration no more than over a several dozen ppm were created by radiation. The antibacterial activity of cefpirome sulfate for two Gram-positive and three Gram-negative strains was changed. The radiation sterilised cefpirome sulfate was not in vitro cytotoxic against fibroblast cells.
authors.affiliation: Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland. Electronic address: pzalewski@ump.edu.pl.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Zalewski
authors.affiliation: Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Skibiński
authors.affiliation: Department of Biotechnology and Food Microbiology, Poznań University of Life Sciences, Wojska Polskiego 48, 60-627 Poznań, Poland.
authors.forename: Daria
authors.initials: D
authors.lastname: Szymanowska-Powałowska
authors.affiliation: Department of Toxicology, Poznan University of Medical Sciences, ul. Dojazd 30, 60-631 Poznań, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Piotrowska
authors.affiliation: Department of Macromolecular Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Kozak
authors.affiliation: Department of Macromolecular Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland.
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Pietralik
authors.affiliation: Institute of Molecular Physics Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Poznań, Poland.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Bednarski
authors.affiliation: Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
authors.forename: Judyta
authors.initials: J
authors.lastname: Cielecka-Piontek
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology / Q000528:radiation effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002511:Cephalosporins / Q000032:analysis* / Q000494:pharmacology / Q000528:radiation effects*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D006801:Humans; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000379:methods; D000097572:Cefpirome
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097572:Cefpirome
keywords: Cefpirome sulfate; Cytotoxicity; Microbiological activity; Q-TOF; Radiation sterilization