title: Management of obstructive sleep apnea in edentulous patients: an overview of the literature.
abstract: OBJECTIVE
  A high prevalence of obstructive sleep apnea (OSA) is seen in edentulous individuals. Treatment options for edentulous OSA patients however are limited with continuous positive airway pressure therapy (CPAP) remaining the current therapy of choice. As CPAP is associated with high non-adherence rates and oral appliance therapy requiring sufficient dentition, there is a clinical need for effective treatment strategies aimed at edentulous OSA patients. The purpose of this study was to present a thorough overview of the literature regarding (1) the effects of nocturnal denture wearing on OSA, (2) the outcomes of oral appliance therapy, and (3) surgical treatment in edentulous OSA patients.
  
  
  METHODS
  A computer-assisted literature search was performed in the MEDLINE database on "edentulism" and "obstructive sleep apnea." The search yielded a total of 34 original articles.
  
  
  RESULTS
  A total of 20 studies were included after exclusion of non-relevant, duplicate, and non-English publications, comprising 4 randomized clinical trials, 12 case reports, and 4 cohort or cross-sectional studies. The outcomes of these studies were addressed in detail concerning nocturnal wearing of dentures, oral appliance therapy, and surgical treatment.
  
  
  CONCLUSIONS
  Currently, there is no consensus in the literature on the effects of nocturnal wearing of dentures on OSA. Several studies report the successful use of oral appliance therapy, including implant-retained mandibular advancement devices (MADs), in selected cases of edentulous patients with varying stages of OSA. Little evidence is available regarding outcomes of surgical procedures in edentulous patients. Based on the results of this literature overview, the paucity of effective evidence-based treatment strategies for edentulous OSA patients indicates the further need of clinical studies to improve clinical management.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Suite A1-121, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. d.s.heidsieck@amc.uva.nl.
authors.forename: David S P
authors.initials: DS
authors.lastname: Heidsieck
authors.affiliation: Department of Oral and Maxillofacial Surgery, Suite A1-121, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: Maurits H T
authors.initials: MH
authors.lastname: de Ruiter
authors.affiliation: Department of Oral and Maxillofacial Surgery, Suite A1-121, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: de Lange
mesh_terms: D000368:Aged; D045422:Continuous Positive Airway Pressure; D003430:Cross-Sectional Studies; D003824:Denture, Complete; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009066:Mouth, Edentulous / Q000150:complications* / Q000453:epidemiology / Q000628:therapy*; D017090:Occlusal Splints; D010159:Palate / Q000601:surgery; D010349:Patient Compliance; D017286:Polysomnography; D012225:Rhinoplasty; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D014139:Tracheostomy
keywords: Dentures; Edentulism; Obstructive sleep apnea; Oral appliance therapy