title: [Effect of arginine vasopressin on alveolar fluid clearance in rats with acute lung injury].
abstract: OBJECTIVE
  To investigate the effect of arginine vasopressin (AVP) on alveolar fluid clearance (AFC) in acute lung injury (ALI).
  
  
  METHODS
  Forty-eight healthy adult Sprague-Dawley rats were randomly divided into control group, ALI model group and AVP treatment group. The pathological changes in the lungs, lung water content, alveolar permeability and AFC were observed, and the expressions of alveolar epithelial sodium channel (ENaC) and Na⁺, K⁺-ATPase were measured.
  
  
  RESULTS
  Compared with those in the model group, the rats treated with AVP showed significantly decreased alveolar permeability (0.27 ± 0.15 vs 0.59 ± 0.19) and lung water content (5.01 ± 1.59 vs 8.67 ± 1.79) (P<0.05) and increased AFC (23.56 ± 4.51 vs 8.28 ± 3.57) and of α-ENaC expressions (1.296 ± 0.322 vs 0.349 ± 0.141) and α1-Na⁺, K⁺-ATPase (1.421 ± 0.389 vs 0.338 ± 0.186) (P<0.05).
  
  
  CONCLUSIONS
  AVP can promote AFC in with ALI possibly by up-regulation of α-ENaC, α1-Na⁺, and K⁺-ATPase.
authors.affiliation: Department of Respiratory Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.E-mail: bsb_dw@163.com.
authors.forename: Wang
authors.initials: W
authors.lastname: Deng
authors.forename: Daoxin
authors.initials: D
authors.lastname: Wang
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D053503:Epithelial Sodium Channels / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D053503:Epithelial Sodium Channels; D001127:Arginine Vasopressin; D000254:Sodium-Potassium-Exchanging ATPase