title: MicroRNA in inflammatory bowel disease: Translational research and clinical implication.
abstract: Idiopathic inflammatory bowel disease (IBD) predominantly includes ulcerative colitis and Crohn's disease. The pathogenesis of IBD is complex and not completely understood. MicroRNAs belong to a class of noncoding small RNAs that post-transcriptionally regulate gene expression. Unique microRNA expression profiles have been explored in IBD. In this review, we focus on the unique microRNA expression pattern in both tissue and peripheral blood from IBD patients and emphasize the potential diagnostic and therapeutic applications. The discovery of microRNAs has contributed to our understanding of IBD pathogenesis and might lead to clinical advance in new therapeutics.
authors.affiliation: Kurt Fisher, Jingmei Lin, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
authors.forename: Kurt
authors.initials: K
authors.lastname: Fisher
authors.affiliation: Kurt Fisher, Jingmei Lin, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
authors.forename: Jingmei
authors.initials: J
authors.lastname: Lin
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D025202:Molecular Diagnostic Techniques; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis; D057170:Translational Research, Biomedical
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs
keywords: Crohn’s disease; Gene expression; Inflammatory bowel disease; MicroRNA; Pathogenesis; Ulcerative colitis