title: The ELF Honest Data Broker: informatics enabling public-private collaboration in a precompetitive arena.
abstract: New precompetitive ways of working in the pharmaceutical industry are driving the development of new informatics systems to enable their execution and management. The European Lead Factory (ELF) is a precompetitive, 30-partner collaboration between academic groups, small-medium enterprises and pharmaceutical companies created to discover small molecule hits against novel biological targets. A unique HTS screening and triage workflow has been developed to balance the intellectual property and scientific requirements of all the partners. Here, we describe the ELF Honest Data Broker, a cloud-based informatics system providing the scientific triage tools, fine-grained permissions and management tools required to implement the workflow.
authors.affiliation: Dassault Systemes, BIOVIA Ltd., 334 Cambridge Science Park, Cambridge CB4 0WN, UK.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Paillard
authors.affiliation: Janssen EMEA, 2340 Turnhoutsweg 30, 2340 Beerse, Belgium; Finia Consulting Ltd, Unit 8 Dock Offices, Surrey Quays Road, London, SE16 2XU, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Cochrane
authors.affiliation: University of Dundee, Biocity Scotland, Bo'ness Road, Newhouse ML1 5SH, UK.
authors.forename: Philip S
authors.initials: PS
authors.lastname: Jones
authors.affiliation: Ex Scientia Ltd, Dundee Incubator, James Lindsay Place, Dundee, DD1 5JJ, United Kingdom.
authors.forename: Willem P
authors.initials: WP
authors.lastname: van Hoorn
authors.affiliation: Dassault Systemes, BIOVIA Ltd., 334 Cambridge Science Park, Cambridge CB4 0WN, UK.
authors.forename: Andrei
authors.initials: A
authors.lastname: Caracoti
authors.affiliation: Janssen EMEA, 2340 Turnhoutsweg 30, 2340 Beerse, Belgium.
authors.forename: Herman
authors.initials: H
authors.lastname: van Vlijmen
authors.affiliation: University of Dundee, Biocity Scotland, Bo'ness Road, Newhouse ML1 5SH, UK. Electronic address: a.pannifer@dundee.ac.uk.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Pannifer
mesh_terms: D003299:Cooperative Behavior; D055808:Drug Discovery / Q000379:methods*; D004345:Drug Industry; D048088:Informatics; D018973:Intellectual Property; D012108:Research Personnel; D054852:Small Molecule Libraries
chemical_list: D054852:Small Molecule Libraries