title: Competitive adsorption equilibrium model with continuous temperature dependent parameters for naringenin enantiomers on Chiralpak AD column.
abstract: Determination of competitive adsorption equilibrium model with continuous temperature dependent parameters is important for the design and optimization of a chromatographic separation process operated under non-isothermal conditions. In this study, linear pulse experiments were first carried to determine the parameters of transport-dispersive model and their temperature dependences in the range of 283–313 K. Overloaded band profiles of naringenin enantiomers on a Chiralpak AD column were acquired under various temperatures. Three of them were first separately fitted using Langmuir, linear-Langmuir and bi-Langmuir isotherm models substituted into the transport-dispersive column model. The comparison showed that bi-Langmuir model captures more details of the experimental results. This model was then extended with three extra parameters accounting for adsorption heat effects and used to simultaneously fit the band profiles at three temperatures.
authors.affiliation: Chemical Engineering Department, Wenzhou University, Wenzhou 325035, Zhejiang, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: Chemical Engineering Department, Wenzhou University, Wenzhou 325035, Zhejiang, China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Jiang
authors.affiliation: API Quality Research Center, Huahai Pharmaceuticals Co. Ltd., Linhai 317024, Zhejiang, China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Guo
authors.affiliation: Chemical Engineering Department, Wenzhou University, Wenzhou 325035, Zhejiang, China.
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Chemical Engineering Department, Wenzhou University, Wenzhou 325035, Zhejiang, China. Electronic address: ywf@wzu.edu.cn.
authors.forename: Weifang
authors.initials: W
authors.lastname: Yu
mesh_terms: D000327:Adsorption; D000688:Amylose / Q000031:analogs & derivatives* / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000379:methods*; D002845:Chromatography; D044950:Flavanones / Q000737:chemistry*; D008962:Models, Theoretical; D048448:Phenylcarbamates / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D044950:Flavanones; D048448:Phenylcarbamates; C080033:Chiralpak AD; D000688:Amylose; C005273:naringenin