title: Magnetically Actuated Wormlike Nanomotors for Controlled Cargo Release.
abstract: Magnetically actuated nanomotor, which swims under externally applied magnetic fields, shows great promise for controlled cargo delivery and release in biological fluids. Here, we report an on-demand release of 6-carboxyfluoresceins (FAM), a green fluorescein, from G-quadruplex DNA functionalized magnetically actuated wormlike nanomotors by applying an alternating magnetic field. This field-triggered FAM releasing process can be easily controlled by multiple parameters such as magnetic field, frequency, and exposure time. In addition, the experimental results and the theoretical simulation demonstrate that both a thermal and a nonthermal mechanism are involved in the cargo releasing process.
authors.affiliation: College of Science, China Three Gorges University , Yichang 443002, Hubei, China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: College of Science, China Three Gorges University , Yichang 443002, Hubei, China.
authors.forename: Liqing
authors.initials: L
authors.lastname: Pan
authors.affiliation: College of Science, China Three Gorges University , Yichang 443002, Hubei, China.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Piao
authors.affiliation: National Center for Electron Microscopy, Tsinghua University , 100084 Beijing, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Sun
authors.affiliation: College of Science, China Three Gorges University , Yichang 443002, Hubei, China.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Huang
authors.affiliation: School of Physics and Electronic Engineering, Jiangsu Normal University , Xuzhou 221116, Jiangsu China.
authors.forename: Changde
authors.initials: C
authors.lastname: Peng
authors.affiliation: College of Science, China Three Gorges University , Yichang 443002, Hubei, China.
authors.forename: Yiman
authors.initials: Y
authors.lastname: Liu
mesh_terms: D003692:Delayed-Action Preparations; D005452:Fluoresceins / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D060526:Magnetic Fields; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D013050:Spectrometry, Fluorescence
chemical_list: D003692:Delayed-Action Preparations; D005452:Fluoresceins; C024098:6-carboxyfluorescein
keywords: CoFe2O4 nanoparticles; HeLa cells; cargo delivery; magnetic actuation; wormlike nanomotor