title: Weight loss therapy for clinical management of patients with some atherosclerotic diseases: a randomized clinical trial.
abstract: BACKGROUND
  The prevalence and burden of atherosclerotic (AS) diseases are increasing during the last twenty years. Some studies show a close relationship between overweight and AS, but influence on AS diseases of different weight loss methods are still studying. The purpose of the research was to study the effectiveness of a weight loss program in AS patients in randomized controlled trial, and to develop a conception of evolution of AS.
  
  
  METHODS
  A randomized controlled prospective clinical trial including 97 people, from them 71 patients with various AS manifestations. Patients were divided in 2 subgroups for non-drug weight loss program, and conventional drug therapy. The weight loss program included calorie restriction with 100-150 kcal/day, fat-free vegetables, salt diet, and optimum physical activity. Statistical analysis was performed using SPSS for Windows version 17.0.
  
  
  RESULTS
  The weight loss subgroup lost ranging between 7-20% from an initial weight (P = 0.016). Weight loss was achieved due to fatty mass reduction only (P = 0.005). Hemoglobin levels (P < 0.001), bone mineral density (P < 0.001), percentages of water (P = 0.006) and muscle masses (P = 0.0038) were increased in weight loss subgroup. Ejection fraction (P < 0.0001), systolic output (P < 0.0001) were increased in patients with coronary artery disease. The weight loss program led to a decrease in symptomatic drugs doses up to total abolition. A conception of AS was developed.
  
  
  CONCLUSIONS
  The weight loss program treated the AS diseases; improved laboratory and instrumental parameters, decreased symptomatic drugs doses. AS development is a logical way of ontogenetic ageing of body fat.
  ClinicalTrials.gov NCT01700075.
  State registration is # 0109RK000079, code is O.0475 at the National Center for Scientific and Technical Information of the Republic of Kazakhstan.
authors.affiliation: Department of metabolic syndrome, National Medical Holding, Astana, Kazakhstan. okp.kuat@mail.ru.
authors.forename: Kuat
authors.initials: K
authors.lastname: Oshakbayev
authors.affiliation: Faculty of pathology and forensic medicine, Medical University Astana, Astana, Kazakhstan. dukenbaeva74@mail.ru.
authors.forename: Bibazhar
authors.initials: B
authors.lastname: Dukenbayeva
authors.affiliation: Department of cardiology, National Medical Holding, Astana, Kazakhstan. otarbaev@rambler.ru.
authors.forename: Nurzhan
authors.initials: N
authors.lastname: Otarbayev
authors.affiliation: Faculty of cardiology, Medical University Astana, Astana, Kazakhstan. gulnar1.01@mail.ru.
authors.forename: Gulnar
authors.initials: G
authors.lastname: Togizbayeva
authors.affiliation: Department of science and education, National Medical Holding, Astana, Kazakhstan. nariman_tab@mail.ru.
authors.forename: Nariman
authors.initials: N
authors.lastname: Tabynbayev
authors.affiliation: Faculty of internal medicine, Karaganda State Medical University, Karaganda, Kazakhstan. gazaliyeva@yandex.ru.
authors.forename: Meruyert
authors.initials: M
authors.lastname: Gazaliyeva
authors.affiliation: Faculty of endocrinology, Medical University Astana, Astana, Kazakhstan. aliser73@mail.ru.
authors.forename: Alisher
authors.initials: A
authors.lastname: Idrisov
authors.affiliation: Department of science and innovations, Medical University Astana, Astana, Kazakhstan. o.peru@mail.ru.
authors.forename: Pernekul
authors.initials: P
authors.lastname: Oshakbayev
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000150:complications*; D031204:Caloric Restriction / Q000379:methods; D018752:Diet, Fat-Restricted / Q000379:methods; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000150:complications* / Q000628:therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D016138:Walking; D015431:Weight Loss