title: Increasing time trends of thin melanomas in The Netherlands: What are the explanations of recent accelerations?
abstract: BACKGROUND
  A disproportional increase in in situ or thin melanomas may point at underlying causes such as increased melanoma awareness, as well as 'overdiagnosis' of melanoma in diagnostically equivocal small lesions.
  
  
  OBJECTIVE
  The purposes of this study were to estimate trends in melanoma incidence by sex, Breslow thickness (thin melanomas subdivided into four subgroups: <0.25 mm, 0.25-0.49 mm, 0.50-0.74 mm, and 0.75-1.0 mm), age and location, and to compare these with trends in subgroups of thicker melanomas.
  
  
  METHODS
  Data on all histologically confirmed in situ and invasive melanomas diagnosed between 1994 and 2010 were retrieved from the Netherlands Cancer Registry. Trends in European standardised rates (ESRs) were assessed using joinpoint analysis, and expressed as estimated annual percentage change (EAPC).
  
  
  RESULTS
  Between 1994 and 2010, 34,156 persons were diagnosed with an in situ or thin melanoma. The ESR of in situ melanomas doubled for males and females with a recent steeper rise in incidence (EAPC 12% (95% confidence interval [CI]: 8.1-16) and 13% (95% CI: 5.9-20), respectively). ESR for thin melanomas amongst males approximately doubled with a steep, but non-significant acceleration compared to other thickness categories since 2006 for <0.25 mm melanomas (EAPC 26% (95% CI: 2.1-35)). For female patients with thin melanomas the ESRs increased almost two-fold, except for <0.25 mm melanomas.
  
  
  CONCLUSIONS
  The incidence rates of in situ, thin and thick melanomas increased similarly between 1994 and 2010. Recently steep increases were found for in situ melanomas and thin melanomas in men. Explanations are 'overdiagnosis' in conjunction with increased ultraviolet exposure (natural and artificial) and therefore a 'true' increase, increased awareness, early detection, diagnostic drift and changed market forces in the Dutch health care system.
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address: r.vanderleest@erasmusmc.nl.
authors.forename: Robert J T
authors.initials: RJ
authors.lastname: van der Leest
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
authors.forename: Judith
authors.initials: J
authors.lastname: Zoutendijk
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
authors.forename: Tamar
authors.initials: T
authors.lastname: Nijsten
authors.affiliation: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Wolter J
authors.initials: WJ
authors.lastname: Mooi
authors.affiliation: Department of Dermatology, LUMC University Medical Center, Leiden, The Netherlands; Department of Dermatology, Centrum Oosterwal, Alkmaar; Medisch Centrum Alkmaar, Alkmaar, The Netherlands.
authors.forename: Jasper I
authors.initials: JI
authors.lastname: van der Rhee
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands; National Cancer Institute, Directorate of Cancer Research, Surveillance, Prevention and Promotion, Bogotá, Colombia.
authors.forename: Esther
authors.initials: E
authors.lastname: de Vries
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
authors.forename: Loes M
authors.initials: LM
authors.lastname: Hollestein
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D000069342:Medical Overuse; D008545:Melanoma / Q000453:epidemiology* / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009426:Netherlands / Q000453:epidemiology; D011237:Predictive Value of Tests; D012042:Registries; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects; D055815:Young Adult
keywords: Breslow thickness; In situ melanoma; Incidence; Melanoma; Overdiagnosis; Thin melanoma