title: Application of the quantitative detection of a change in concentration of magnesium stearate in a feeder tube of tableting manufacture by real-time near-infrared spectroscopy.
abstract: Process analytical technology is important for the analysis and control of manufacturing processes. Near-infrared spectroscopy is widely used in various process analytical technologies for the analysis of the chemical componentsof solid dosage forms. Lubrication is an important process carried out before a tablet is produced. In this process, the concentration of lubricant, such as magnesium stearate (StMg), might change for one of many reasons during powder transport, which would be a critical problem such as variation in tablet compressibility and dissolution failure of compressed tablets. Our group investigated the feasibility of the quantitative monitoring of a change in the concentration of StMg in the feeder tube of tableting equipment employing real-time near-infrared spectroscopy.
authors.forename: D
authors.initials: D
authors.lastname: Sasakura
authors.forename: K
authors.initials: K
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Chikuma
mesh_terms: D003199:Computer Systems; D004339:Drug Compounding / Q000295:instrumentation* / Q000379:methods*; D004345:Drug Industry; D005079:Excipients / Q000032:analysis*; D016018:Least-Squares Analysis; D012044:Regression Analysis; D019265:Spectroscopy, Near-Infrared; D013229:Stearic Acids / Q000032:analysis*; D013607:Tablets
chemical_list: D005079:Excipients; D013229:Stearic Acids; D013607:Tablets; C031183:stearic acid