title: Chemoselective Synthesis of 1-Substituted 4-Amino-2-(trifluoromethyl)-1H-pyrroles through the Heterocyclization Reaction of 4-Methoxy-5-bromo-1,1,1-trifluoropent-3-en-2-ones with Amines.
abstract: A concise method to synthesize 1-substituted 4-amino-2-(trifluoromethyl)-1H-pyrroles from the heterocyclization reaction of 5-bromo-4-methoxy-1,1,1-trifluoropent-3-en-2-ones with amines is described. This method has the following advantages: it uses a wide range of primary amines, starting materials are easily available, it is simple to perform, the reaction conditions are mild, it is environmentally friendly, and it furnishes yields of up to 98%.
authors.affiliation: Núcleo de Quı́mica de Heterociclos (NUQUIMHE), Departamento de Quı́mica, Universidade Federal de Santa Maria , 97105-900 Santa Maria, Brazil.
authors.forename: Estefania da C
authors.initials: Eda C
authors.lastname: Aquino
authors.affiliation: Núcleo de Quı́mica de Heterociclos (NUQUIMHE), Departamento de Quı́mica, Universidade Federal de Santa Maria , 97105-900 Santa Maria, Brazil.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Leonel
authors.affiliation: Núcleo de Quı́mica de Heterociclos (NUQUIMHE), Departamento de Quı́mica, Universidade Federal de Santa Maria , 97105-900 Santa Maria, Brazil.
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Gariboti
authors.affiliation: Núcleo de Quı́mica de Heterociclos (NUQUIMHE), Departamento de Quı́mica, Universidade Federal de Santa Maria , 97105-900 Santa Maria, Brazil.
authors.forename: Clarissa P
authors.initials: CP
authors.lastname: Frizzo
authors.affiliation: Núcleo de Quı́mica de Heterociclos (NUQUIMHE), Departamento de Quı́mica, Universidade Federal de Santa Maria , 97105-900 Santa Maria, Brazil.
authors.forename: Marcos A P
authors.initials: MA
authors.lastname: Martins
authors.affiliation: Núcleo de Quı́mica de Heterociclos (NUQUIMHE), Departamento de Quı́mica, Universidade Federal de Santa Maria , 97105-900 Santa Maria, Brazil.
authors.forename: Helio G
authors.initials: HG
authors.lastname: Bonacorso
authors.affiliation: Núcleo de Quı́mica de Heterociclos (NUQUIMHE), Departamento de Quı́mica, Universidade Federal de Santa Maria , 97105-900 Santa Maria, Brazil.
authors.forename: Nilo
authors.initials: N
authors.lastname: Zanatta