title: The excess mortality of patients with diabetes and concurrent psychiatric illness is markedly reduced by structured personal diabetes care: A 19-year follow up of the randomized controlled study Diabetes Care in General Practice (DCGP).
abstract: OBJECTIVE
  To assess the effectiveness of an intervention in Type 2 diabetic patients with concurrent psychiatric illness (PI) and compare this with the effectiveness in patients without PI.
  
  
  METHODS
  In the Diabetes Care in General Practice trial, 1381 patients newly diagnosed with Type 2 diabetes were randomized to 6 years of structured personal diabetes care or routine diabetes care (ClinicalTrials.gov NCT01074762). In this observational post-hoc analysis, the effectiveness of the intervention for diabetes in 179 patients with concurrent PI was analyzed.
  
  
  RESULTS
  During the 19-year follow-up period, patients with PI in the structured personal care group experienced a lower risk for all-cause mortality [105.3 vs. 140.4 events per 1000 patient-years; hazard ratio (HR): 0.63, P=0.023, multivariably adjusted], diabetes-related death (66.0 vs. 95.1; HR: 0.57, P=0.015), any diabetes-related endpoint (169.5 vs. 417.5; HR: 0.47, P=0.0009) and myocardial infarction (54.1 vs. 104.4; HR: 0.48, P=0.013), compared to patients with PI in the routine care group. This translates into a number needed to treat over 10 years of three or lower for these outcomes.
  
  
  CONCLUSIONS
  These findings suggest that in primary care, structured diabetes care allowing for individualization was highly effective among diabetic patients with co-occurring PI.
authors.affiliation: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark; Psychiatric Centre Copenhagen and Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Julie Rask
authors.initials: JR
authors.lastname: Larsen
authors.affiliation: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark.
authors.forename: Volkert D
authors.initials: VD
authors.lastname: Siersma
authors.affiliation: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark.
authors.forename: Annette S
authors.initials: AS
authors.lastname: Davidsen
authors.affiliation: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark.
authors.forename: Frans B
authors.initials: FB
authors.lastname: Waldorff
authors.affiliation: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark.
authors.forename: Susanne
authors.initials: S
authors.lastname: Reventlow
authors.affiliation: The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, DK-1014 Copenhagen K, Denmark. Electronic address: olivarius@sund.ku.dk.
authors.forename: Niels
authors.initials: N
authors.lastname: de Fine Olivarius
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality*; D002423:Cause of Death; D015897:Comorbidity; D003718:Denmark; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000401:mortality* / Q000523:psychology / Q000628:therapy; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D008875:Middle Aged; D009026:Mortality; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology / Q000401:mortality; D016491:Peripheral Vascular Diseases / Q000453:epidemiology / Q000401:mortality; D057285:Precision Medicine; D011320:Primary Health Care / Q000379:methods*; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic; D012648:Self Care; D020521:Stroke / Q000453:epidemiology / Q000401:mortality
keywords: All-cause mortality; Primary care; Psychiatric illness; Randomized controlled trial; Type 2 diabetes mellitus