title: A Structuring Repeat for Peptide Design: Long Beta Ribbons.
abstract: Beta sheets are inherently length-limited; adding residues to the ends of model β-sheets does not necessarily grow the β-sheet. Here, we present a method for extending β-sheets to any length with a stabilizing repeat unit containing cross-strand Trp residues. Beta ribbons as long as 35 residues (approaching 100 Å in length) are reported and characterized.
authors.affiliation: Department of Chemistry, University of Washington, Box 351700, Bagley Hall, Seattle, WA, 98195-1700, USA. sciguy@u.washington.edu.
authors.forename: Brandon L
authors.identifier: http://orcid.org/0000-0002-6056-2246
authors.initials: BL
authors.lastname: Kier
authors.affiliation: Department of Chemical Engineering, University of Washington, Box 351750, Benson Hall, Seattle, WA, 98195-1750, USA.
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Newbloom
authors.affiliation: Department of Chemical Engineering, University of Washington, Box 351750, Benson Hall, Seattle, WA, 98195-1750, USA.
authors.forename: Lilo D
authors.initials: LD
authors.lastname: Pozzo
authors.affiliation: Department of Chemistry, University of Washington, Box 351700, Bagley Hall, Seattle, WA, 98195-1700, USA. andersen@chem.washington.edu.
authors.forename: Niels H
authors.initials: NH
authors.lastname: Andersen
mesh_terms: D000595:Amino Acid Sequence; D002942:Circular Dichroism; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
chemical_list: D010455:Peptides
keywords: beta-caps; beta-sheets; bioengineering; disulfide; peptide