title: Baicalin may have a therapeutic effect in attention deficit hyperactivity disorder.
abstract: Baicalin is a flavonoid purified from Scutellaria baicalensis Georgi. It possesses a variety of pharmacological properties, such as anti-inflammatory, antioxidant, antiapoptotic, and neuro-protective properties, and provides protection against cerebral hemorrhage. However, it is seldom considered a therapeutic in mental disorders. Recent studies showed that baicalin protects cerebral functions against ischemia and has sedative and anxiolytic-like effects. Animal experiments showed that it protects dopaminergic neurons in the striatum, hippocampus and substantia nigra. It also has effects such as anti-depressive and anti-epileptic and offers resistance to Parkinson's disease. Attention deficit hyperactivity disorder (ADHD) pathogenesis is closely related to dopamine deficiency. However, the therapeutic effect of baicalin in ADHD has not been studied. We hypothesize that baicalin may protect dopaminergic neurons and increase brain dopamine levels, thus serving as an effective novel treatment for ADHD.
authors.forename: Rongyi
authors.initials: R
authors.lastname: Zhou
authors.forename: Xinmin
authors.initials: X
authors.lastname: Han
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Wang
authors.forename: Jichao
authors.initials: J
authors.lastname: Sun
mesh_terms: D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000928:Antidepressive Agents; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D059290:Dopaminergic Neurons / Q000187:drug effects* / Q000502:physiology*; D019317:Evidence-Based Medicine; D005419:Flavonoids / Q000008:administration & dosage*; D006801:Humans; D008959:Models, Neurological; D018696:Neuroprotective Agents / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000928:Antidepressive Agents; D005419:Flavonoids; D018696:Neuroprotective Agents; C038044:baicalin