title: Perioperative myocardial infarction/injury after noncardiac surgery.
abstract: Cardiovascular complications, particularly perioperative myocardial infarction/injury, seem to be major contributors to mortality after noncardiac surgery. With surgical procedures being very frequent (900 000/year in Switzerland), perioperative myocardial injury is common in everyday clinical practice. Over 80% of patients experiencing perioperative myocardial injury do not report symptoms. Therefore perioperative myocardial injury remains undiagnosed and untreated. Moreover, its silent presentation results in limited awareness among both clinicians and the public. Despite being largely asymptomatic, perioperative myocardial injury increases 30-day mortality nearly 10-fold. This review aims to increase the awareness of perioperative myocardial injury/infarction and give an overview of the emerging evidence, including pathophysiology, clinical presentation, prevention, and potential future treatments.
authors.affiliation: Cardiology and Anaesthesia, University Hospital Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Puelacher
authors.affiliation: Cardiology and Anaesthesia, University Hospital Basel, Switzerland.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Lurati-Buse
authors.affiliation: Cardiology and Anaesthesia, University Hospital Basel, Switzerland.
authors.forename: Hélène
authors.initials: H
authors.lastname: Singeisen
authors.affiliation: Cardiology and Anaesthesia, University Hospital Basel, Switzerland.
authors.forename: Minh
authors.initials: M
authors.lastname: Dang
authors.affiliation: Cardiology and Anaesthesia, University Hospital Basel, Switzerland.
authors.forename: Florim
authors.initials: F
authors.lastname: Cuculi
authors.affiliation: Cardiology and Anaesthesia, University Hospital Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Müller
mesh_terms: D001364:Awareness; D015415:Biomarkers; D002317:Cardiovascular Agents / Q000008:administration & dosage; D004562:Electrocardiography; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D059035:Perioperative Period / Q000706:statistics & numerical data*; D012307:Risk Factors; D013557:Switzerland; D055986:Vital Signs
chemical_list: D015415:Biomarkers; D002317:Cardiovascular Agents