title: Inference of directional selection and mutation parameters assuming equilibrium.
abstract: In a classical study, Wright (1931) proposed a model for the evolution of a biallelic locus under the influence of mutation, directional selection and drift. He derived the equilibrium distribution of the allelic proportion conditional on the scaled mutation rate, the mutation bias and the scaled strength of directional selection. The equilibrium distribution can be used for inference of these parameters with genome-wide datasets of "site frequency spectra" (SFS). Assuming that the scaled mutation rate is low, Wright's model can be approximated by a boundary-mutation model, where mutations are introduced into the population exclusively from sites fixed for the preferred or unpreferred allelic states. With the boundary-mutation model, inference can be partitioned: (i) the shape of the SFS distribution within the polymorphic region is determined by random drift and directional selection, but not by the mutation parameters, such that inference of the selection parameter relies exclusively on the polymorphic sites in the SFS; (ii) the mutation parameters can be inferred from the amount of polymorphic and monomorphic preferred and unpreferred alleles, conditional on the selection parameter. Herein, we derive maximum likelihood estimators for the mutation and selection parameters in equilibrium and apply the method to simulated SFS data as well as empirical data from a Madagascar population of Drosophila simulans.
authors.affiliation: Institute of Animal Breeding and Genetics, Veterinärmedizinische Universität Wien, Veterinärplatz 1, A-1210 Vienna, Austria. Electronic address: claus.vogl@vetmeduni.ac.at.
authors.forename: Claus
authors.initials: C
authors.lastname: Vogl
authors.affiliation: Institute of Population Genetics, Veterinärmedizinische Universität Wien, Veterinärplatz 1, A-1210 Vienna, Austria; Vienna Graduate School of Population Genetics, Veterinärmedizinische Universität Wien, Veterinärplatz 1, A-1210 Vienna, Austria. Electronic address: juraj.bergman@vetmeduni.ac.at.
authors.forename: Juraj
authors.initials: J
authors.lastname: Bergman
mesh_terms: D000483:Alleles; D000818:Animals; D000067636:Drosophila simulans / Q000235:genetics*; D019143:Evolution, Molecular; D005787:Gene Frequency; D005828:Genetics, Population / Q000379:methods*; D016013:Likelihood Functions; D008957:Models, Genetic; D009154:Mutation; D012641:Selection, Genetic
keywords: Biallelic mutation–selection–drift model; Equilibrium density; Inference; Small scaled mutation rate