title: Syzygium cumini (L.) skeels: a prominent source of bioactive molecules against cardiometabolic diseases.
abstract: Syzygium cumini (Myrtaceae) is a worldwide medicinal plant traditionally used in herbal medicines due to its vaunted properties against cardiometabolic disorders, which include: antihyperglycemic, hypolipemiant, antiinflammatory, cardioprotective, and antioxidant activities. These properties have been attributed to the presence of bioactive compounds such as phenols, flavonoids, and tannins in different parts of the plant, albeit the knowledge on their mechanisms of action is scarce. This mini-review highlights the cardiometabolic properties of S. cumini by correlating its already identified phytochemicals with their described mechanisms of action. Data herein compiled show that some compounds target multiple metabolic pathways; thereby, becoming potential pharmacological tools. Moreover, the lack of clinical trials on S. cumini usage makes it a fruitful field of interest for both scientific community and pharmaceutical industry.
authors.affiliation: Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão São Luís, Brazil ; Graduate Program in Health Sciences, Biological and Health Sciences Center, Federal University of Maranhão São Luís, Brazil.
authors.forename: Vinicyus Teles
authors.initials: VT
authors.lastname: Chagas
authors.affiliation: Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão São Luís, Brazil ; Graduate Program in Health Sciences, Biological and Health Sciences Center, Federal University of Maranhão São Luís, Brazil.
authors.forename: Lucas Martins
authors.initials: LM
authors.lastname: França
authors.affiliation: Graduate Program in Health Sciences, Biological and Health Sciences Center, Federal University of Maranhão São Luís, Brazil.
authors.forename: Sonia
authors.initials: S
authors.lastname: Malik
authors.affiliation: Laboratory of Experimental Physiology, Department of Physiological Sciences, Federal University of Maranhão São Luís, Brazil ; Graduate Program in Health Sciences, Biological and Health Sciences Center, Federal University of Maranhão São Luís, Brazil.
authors.forename: Antonio Marcus de Andrade
authors.initials: AM
authors.lastname: Paes
keywords: black plum; complementary and alternative medicine; ethnopharmacology; jamun; medicinal plants; metabolic syndrome; myrtaceae; phenolic compounds