title: Five Simultaneous Primary Tumors in a Single Patient: A Case Report and Review of the Literature.
abstract: Multiple primary malignancies (MPMs) are present when a patient is diagnosed with more than one primary malignancy and when each tumor is histologically unrelated to the others. MPMs are considered synchronous when they present within 6 months of one another. Here, we report the case of a 57-year-old woman with a past medical history significant for melanoma in 1988, who presented in 2014 with 5 distinct tumors within 4 months: malignant melanoma of the right popliteal fossa, invasive lobular breast carcinoma, diffuse large B cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and a giant cell tumor of tendon sheath/pigmented villonodular synovitis. We discuss her treatment and also present a brief review of the literature. The incidence of MPMs appears to be on the rise, which demands an interdisciplinary, multimodal, and personalized approach to care.
authors.affiliation: Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, Calif., USA.
authors.forename: Casey W
authors.initials: CW
authors.lastname: Williamson
authors.affiliation: Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, Calif., USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Paravati
authors.affiliation: Department of Pathology, Kaiser Permanente, San Diego, Calif., USA.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghassemi
authors.affiliation: Department of Hematology-Oncology, Kaiser Permanente, San Diego, Calif., USA.
authors.forename: Kristine
authors.initials: K
authors.lastname: Lethert
authors.affiliation: Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, Calif., USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Hua
authors.affiliation: Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, Calif., USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartman
authors.affiliation: Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, Calif., USA.
authors.forename: Parag
authors.initials: P
authors.lastname: Sanghvi
keywords: Breast cancer; Giant cell tumor; Lymphoma; Melanoma; Multiple malignancies