title: Altered interhemispheric resting state functional connectivity during passive hyperthermia.
abstract: OBJECTIVE
  This study examines the effect of passive hyperthermia on interhemispheric resting state functional connectivity and the correlation between interhemispheric resting state functional connectivity and efficiency of a succedent working memory task.
  
  
  METHODS
  We performed voxel-mirrored homotopic connectivity (VMHC) analyses on resting state MRI data and a one-back task from 14 healthy subjects in both HT (hyperthermia, 50 °C) conditions and normal control (NC, 25 °C) conditions. The group analyses of the differences for VMHC between the two conditions and the correlation analysis between the VMHC and the reaction time (RT) of the one-back task were performed with the statistical parametric mapping software package and the software REST.
  
  
  RESULTS
  Compared with NC conditions, HT conditions increased VMHC in the cuneus, the postcentral gyrus, and the fusiform gyrus. No region showed decreased VMHC in the HT group in comparison with the NC group. For NC conditions, negative correlations were demonstrated between RT of the one-back task and VMHC in bilateral superior temporal gyrus, and bilateral middle frontal gyrus; for HT conditions, negative correlations were demonstrated between RT and VMHC in bilateral inferior frontal gyrus, bilateral middle frontal gyrus, as well as cerebellum posterior lobe.
  
  
  CONCLUSIONS
  Passive heat stress can impact the interhemispheric information interactions at resting state and the VMHC deficits may play an important role in cognitive dysfunction.
authors.affiliation: a Department of Medical Imaging , Jinan Military General Hospital , Shandong , China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.affiliation: a Department of Medical Imaging , Jinan Military General Hospital , Shandong , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: a Department of Medical Imaging , Jinan Military General Hospital , Shandong , China.
authors.forename: Shaowen
authors.initials: S
authors.lastname: Qian
authors.affiliation: a Department of Medical Imaging , Jinan Military General Hospital , Shandong , China.
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: a Department of Medical Imaging , Jinan Military General Hospital , Shandong , China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: a Department of Medical Imaging , Jinan Military General Hospital , Shandong , China.
authors.forename: Gang
authors.initials: G
authors.lastname: Sun
mesh_terms: D000328:Adult; D001831:Body Temperature; D001835:Body Weight; D003071:Cognition; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term; D013312:Stress, Physiological / Q000502:physiology*; D055815:Young Adult
keywords: Passive hyperthermia; functional MRI; resting state; voxel-mirrored homotopic connectivity; working memory