title: Notch Signaling: Piercing a Harness of Simplicity.
abstract: The Notch pathway is an attractive therapeutic target for treatment of cancer and T cell-mediated pathology, but Notch inhibition leads to many side effects. Pinnell et al. (2015) demonstrate that oncogenic functions can be separated biochemically from other functions of Notch, opening new options for more selective targeting of this pathway.
authors.affiliation: Department of Hematopoiesis, Sanquin and Landsteiner Laboratory for Blood Research, 1066CX Amsterdam, the Netherlands.
authors.forename: Christina
authors.initials: C
authors.lastname: Helbig
authors.affiliation: Department of Hematopoiesis, Sanquin and Landsteiner Laboratory for Blood Research, 1066CX Amsterdam, the Netherlands. Electronic address: d.amsen@sanquin.nl.
authors.forename: Derk
authors.initials: D
authors.lastname: Amsen
mesh_terms: D000818:Animals; D006801:Humans; D007938:Leukemia / Q000378:metabolism*; D050828:Protein Inhibitors of Activated STAT / Q000378:metabolism*; D051881:Receptor, Notch1 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D050828:Protein Inhibitors of Activated STAT; D051881:Receptor, Notch1; D014157:Transcription Factors