title: A randomized controlled experimental study comparing chitosan coated polypropylene mesh and Proceed™ mesh for abdominal wall defect closure.
abstract: BACKGROUND
  Abdominal wall defects and hernias are commonly repaired with synthetic or biological materials. Adhesions and recurrences are a common problem. A study was conducted to compare Chitosan coated polypropylene mesh and a polypropylene-polydioxanone composite with oxidized cellulose coating mesh (Proceed™) in repair of abdominal wall defect in a Rabbit hernia model.
  
  
  METHODS
  A randomized controlled experimental study was done on twelve New Zealand white rabbits. A ventral abdominal defect was created in each of the rabbits. The rabbits were divided into two groups. In one group the defect was repaired with Chitosan coated polypropylene mesh and Proceed mesh™ in the other. The rabbits were operated in two phases. They were followed up at four weeks and twelve weeks respectively after which the rabbits were sacrificed. They were evaluated by open exploration and histopathological examination. Their efficacy in reducing adhesion and ability of remodeling and tissue integration were studied.
  
  
  RESULTS
  There was no statistical significance in the area of adhesion, the force required to remove the adhesions, tissue integration and remodeling between Chitosan and Proceed™ group. Histological analysis revealed that the inflammatory response, fibrosis, material degradation and remodeling were similar in both the groups. There were no hernias, wound infection or dehiscence in any of the studied animals.
  
  
  CONCLUSIONS
  Chitosan coated polypropylene mesh was found to have similar efficacy to Proceed™ mesh. Chitosan coated polypropylene mesh, can act as an anti adhesive barrier when used in the repair of incisional hernias and abdominal wall defects.
authors.affiliation: Department of General Surgery, Christian Medical College, Vellore, India.
authors.forename: S T
authors.initials: ST
authors.lastname: Jayanth
authors.affiliation: Department of Pathology, Christian Medical College, Vellore, India.
authors.forename: Anna
authors.initials: A
authors.lastname: Pulimood
authors.affiliation: Department of Endocrine Surgery, Christian Medical College, Vellore, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Abraham
authors.affiliation: Department of Biophysics, Central Leather Research Institute, Chennai, India.
authors.forename: A
authors.initials: A
authors.lastname: Rajaram
authors.affiliation: Department of Endocrine Surgery, Christian Medical College, Vellore, India.
authors.forename: M J
authors.initials: MJ
authors.lastname: Paul
authors.affiliation: Department of Endocrine Surgery, Christian Medical College, Vellore, India.
authors.forename: Aravindan
authors.initials: A
authors.lastname: Nair
keywords: Abdominal wall defect; Adhesions; Chitosan; Experimental study