title: Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering.
abstract: The structural features of bone engineering scaffolds are expected to exhibit osteoinductive behavior and promote cell adhesion, proliferation, and differentiation. In the present study, we employed synthesized ordered mesoporous calcium-magnesium silicate (om-CMS) and polybutylene succinate (PBSu) to develop a novel scaffold with potential applications in osseous tissue engineering. The characteristics, in vitro bioactivity of om-CMS/PBSu scaffold, as well as the cellular responses of MC3T3-E1 cells to the composite were investigated. Our results showed that the om-CMS/PBSu scaffold possesses a large surface area and highly ordered channel pores, resulting in improved degradation and biocompatibility compared to the PBSu scaffold. Moreover, the om-CMS/PBSu scaffold exhibited significantly higher bioactivity and induced apatite formation on its surface after immersion in the simulated body fluid. In addition, the om-CMS/PBSu scaffold provided a high surface area for cell attachment and released Ca, Mg, and Si ions to stimulate osteoblast proliferation. The unique surface characteristics and higher biological efficacy of the om-CMS/PBSu scaffold suggest that it has great potential for being developed into a system that can be employed in osseous tissue engineering.
authors.affiliation: TongRen Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.affiliation: TongRen Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Biao
authors.initials: B
authors.lastname: Zhong
authors.affiliation: Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.affiliation: Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China.
authors.forename: Quanxiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China.
authors.forename: Jiajin
authors.initials: J
authors.lastname: Ji
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.affiliation: TongRen Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017636:Asbestos, Amphibole / Q000494:pharmacology*; D001842:Bone and Bones / Q000502:physiology*; D002072:Butylene Glycols / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008970:Molecular Weight; D009584:Nitrogen / Q000737:chemistry; D011108:Polymers / Q000494:pharmacology*; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D017636:Asbestos, Amphibole; D002072:Butylene Glycols; D011108:Polymers; C089797:bionole; C005846:tremolite; D009584:Nitrogen
keywords: bone repair; calcium–magnesium silicate; ordered mesoporous; polybutylene succinate; proliferation