title: The neuroprotection of hypoxic preconditioning on rat brain against traumatic brain injury by up-regulated transcription factor Nrf2 and HO-1 expression.
abstract: Hypoxic preconditioning (HPC) increases the inherent tolerance of brain tissue suffering from severe hypoxia or ischemia insult by stimulating the protective ability of the brain. However, little is known concerning the effect of HPC on traumatic brain injury (TBI). We designed this study to investigate the effect of HPC on TBI and explore its underlying mechanisms. We found that HPC significantly alleviates neurological dysfunction, lessens brain edema, reduces cell apoptosis, increases neuronal survival, up-regulates the expressions of Nrf2 and HO-1, and decreases the inducer of protein carbonyls, 4-hydroxy-2-nonenal, and 8-hydroxy-2-deoxyguanosine in the brain tissue of rats 24h after brain injury. However, no influence was observed in normal rats after only 3d of hypoxic training. Results further indicated that HPC protects the brain against traumatic damage. This protective effect may be achieved by up-regulating Nrf2 and HO-1 expression and alleviating oxidative stress damage.
authors.affiliation: Department of Neurosurgery, 105 Hospital of PLA, Clinical College of PLA, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Longfei
authors.initials: L
authors.lastname: Shu
authors.affiliation: Department of Neurosurgery, 105 Hospital of PLA, Clinical College of PLA, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, 105 Hospital of PLA, Clinical College of PLA, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Jinbiao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, 105 Hospital of PLA, Clinical College of PLA, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, 105 Hospital of PLA, Clinical College of PLA, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, 105 Hospital of PLA, Clinical College of PLA, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, 105 Hospital of PLA, Clinical College of PLA, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhuo
authors.affiliation: Department of Neurosurgery, 105 Hospital of PLA, Clinical College of PLA, Anhui Medical University, Hefei, Anhui 230031, China. Electronic address: ljc571017@sina.com.
authors.forename: Jiachuan
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001929:Brain Edema / Q000473:pathology / Q000517:prevention & control; D001930:Brain Injuries / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D002470:Cell Survival; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D002534:Hypoxia, Brain; D008297:Male; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D009474:Neurons / Q000473:pathology; D018384:Oxidative Stress; D050050:Protein Carbonylation; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction
chemical_list: D051267:NF-E2-Related Factor 2; C495637:Nfe2l2 protein, rat; D051547:Heme Oxygenase-1
keywords: Heme oxygenase-1; Hypoxic preconditioning; Nuclear factor erythroid 2-related factor 2p; Traumatic brain injury