title: A new method testing the orthogonality of different protecting groups.
abstract: A new test was elaborated to identify a new set of orthogonal protecting groups. With the developed method eight different protecting groups were tested under various deprotection conditions and the complex reaction mixtures were analysed by HPLC. The developed method allows for quick identification of orthogonality using simple model structures.
authors.affiliation: Institute of Organic Chemistry, RCNS-HAS, Magyar Tudósok Körútja 2, 1117 Budapest, Hungary; Carbosynth LTD, 8&9 Old Station Business Park, RG20 6NE Compton, UK. Electronic address: karoly.agoston@carbosynth.com.
authors.forename: Károly
authors.initials: K
authors.lastname: Ágoston
authors.affiliation: Lab-Comp LTD, Rákos Tér 23/A, 1142 Budapest, Hungary.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Ágoston
authors.affiliation: Carbosynth LTD, 8&9 Old Station Business Park, RG20 6NE Compton, UK.
authors.forename: Colin R
authors.initials: CR
authors.lastname: Dorgan
authors.affiliation: Institute of Organic Chemistry, RCNS-HAS, Magyar Tudósok Körútja 2, 1117 Budapest, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Fügedi
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: D001688:Biological Products; D005960:Glucosides
keywords: Method development; Orthogonal protection; Protecting groups