title: Nailfold capillaroscopic findings in primary Sjögren's syndrome with and without Raynaud's phenomenon and/or positive anti-SSA/Ro and anti-SSB/La antibodies.
abstract: The aim of this study was to assess nailfold capillaroscopic (NC) findings in patients with primary Sjögren's syndrome (PSS) with and without Raynaud's phenomenon (RP) as well as in the presence of positive anti-SSA/Ro and anti-SSB/La antibodies. Videocapillaroscopy was performed in 150 patients with PSS. Data collected included demographics, presence of RP, PSS symptoms, antinuclear antibodies, rheumatoid factor, anti-Ro, anti-La, anti-CCP, salivary scintigraphy, labial biopsy, and NC findings. RP was present in 32% of PSS, keratoconjunctivitis sicca in 91%, oral xerosis in 93%, and skin or genital xerosis in 53%. In patients with positive anti-SSA/Ro (75%) and positive anti-SSB/La (40%), NC showed normal findings in 53% of cases and non-specific in 36%. In patients with PSS, NC was normal in 51% of cases and non-specific in 34%. Scleroderma pattern was found in 14 patients. RP associated with PSS had non-specific capillaroscopy in 40% of cases (p = 0.1). Pericapillary haemorrhages (p = 0.06) and capillary thrombosis (p = 0.2) were not increased, but more dilated capillaries were detected in 48% of cases. Patients with positive anti-Ro and/or anti-La have not a distinct NC profile. Patients with RP associated with PSS had more dilated capillaries, but neither pericapillary haemorrhages nor capillary thrombosis was observed.
authors.affiliation: Service of Rheumatology, Hospital de Sant Joan Despí Moisés Broggi-Hospital General Hospitalet, Consorci Sanitari Integral (CSI), Avda. Jacint Verdaguer 90, 08970, Sant Joan Despí, Barcelona, Catalonia, Spain. vancor@yahoo.com.
authors.forename: Hèctor
authors.initials: H
authors.lastname: Corominas
authors.affiliation: Service of Rheumatology, Hospital de Granollers, Granollers, Barcelona, Spain. veraortiz@hotmail.com.
authors.forename: Vera
authors.initials: V
authors.lastname: Ortiz-Santamaría
authors.affiliation: Service of Rheumatology, Hospital Universitari de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. ivancastellvi@hotmail.com.
authors.forename: Iván
authors.initials: I
authors.lastname: Castellví
authors.affiliation: Service of Rheumatology, Hospital Corporació Parc Taulí, Sabadell, Barcelona, Spain. mmoreno@tauli.cat.
authors.forename: Mireia
authors.initials: M
authors.lastname: Moreno
authors.affiliation: Service of Rheumatology, Hospital del Vendrell, El Vendrell, Tarragona, Spain. rmmorla@gmail.com.
authors.forename: Rosa
authors.initials: R
authors.lastname: Morlà
authors.affiliation: Service of Rheumatology, Hospital de Palamós, Palamós, Girona, Spain. tclava1@yahoo.es.
authors.forename: Teresa
authors.initials: T
authors.lastname: Clavaguera
authors.affiliation: Service of Rheumatology, Hospital Sant Rafael, Barcelona, Spain. aerra@hsrafael.es.
authors.forename: Alba
authors.initials: A
authors.lastname: Erra
authors.affiliation: Service of Rheumatology, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain. smartinez@mutuaterrasa.cat.
authors.forename: Silvia
authors.initials: S
authors.lastname: Martínez-Pardo
authors.affiliation: Service of Rheumatology, Hospital Arnau de Vilanova, Lleida, Spain. ordonezsergi@gmail.com.
authors.forename: Sergi
authors.initials: S
authors.lastname: Ordóñez
authors.affiliation: Service of Rheumatology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. pili_santo@yahoo.es.
authors.forename: Pilar
authors.initials: P
authors.lastname: Santo
authors.affiliation: Service of Rheumatology, Hospital de Santa Caterina, Girona, Spain. preyner1@hotmail.com.
authors.forename: Patricia
authors.initials: P
authors.lastname: Reyner
authors.affiliation: Service of Rheumatology, Hospital Universitari Quirón Dexeus, Barcelona, Spain. mj_gonzalez@hotmail.com.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: González
authors.affiliation: Service of Rheumatology, Hospital de Figueres, Figueres, Girona, Spain. ocodina@salutemporda.cat.
authors.forename: Oriol
authors.initials: O
authors.lastname: Codina
authors.affiliation: Service of Rheumatology, Fundació Althaia Hospital de Manresa, Manresa, Barcelona, Spain. 14979sga@comb.cat.
authors.forename: Mario Saul
authors.initials: MS
authors.lastname: Gelman
authors.affiliation: Service of Rheumatology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. x.juanola@bellvitgehospital.cat.
authors.forename: Xavier
authors.initials: X
authors.lastname: Juanola-Roura
authors.affiliation: Service of Rheumatology, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain. aolive.germanstrias@gencat.cat.
authors.forename: Alex
authors.initials: A
authors.lastname: Olivé
authors.affiliation: Service of Rheumatology, Hospital de Sant Joan Despí Moisés Broggi-Hospital General Hospitalet, Consorci Sanitari Integral (CSI), Avda. Jacint Verdaguer 90, 08970, Sant Joan Despí, Barcelona, Catalonia, Spain. vicente.torrente@sanitatintegral.org.
authors.forename: Vicenç
authors.initials: V
authors.lastname: Torrente-Segarra
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation; D020678:Microscopic Angioscopy / Q000379:methods*; D008875:Middle Aged; D009262:Nails / Q000098:blood supply*; D011237:Predictive Value of Tests; D011928:Raynaud Disease / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D012039:Regional Blood Flow; D012859:Sjogren's Syndrome / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D013030:Spain; D014741:Video Recording
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers; C035356:SS-A antibodies; C035357:SS-B antibodies
keywords: Antibodies, antinuclear; Connective tissue diseases; Microscopic angioscopy; Raynaud’s disease; Sjögren’s syndrome; Systemic sclerosis