title: Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine.
abstract: This paper describes the highly selective, sensitive and topology-specific fluorescent sensing of dimeric G-quadruplexes by a polyether-tethered dimeric berberine 1. Compound 1 displays high selectivity for dimeric G-quadruplexes over monomeric ones, and can be lit up by dimeric G-quadruplexes, in particular by the one linked with one TTA subunit. In addition, it shows no effect on the topology or thermal stability of the G-quadruplexes.
authors.affiliation: Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China. whchen@smu.edu.cn.
authors.forename: Chun-Qiong
authors.initials: CQ
authors.lastname: Zhou
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Yang
authors.forename: Cheng
authors.initials: C
authors.lastname: Dong
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.forename: Jin-Xiang
authors.initials: JX
authors.lastname: Chen
authors.forename: Ya-Shi
authors.initials: YS
authors.lastname: Xu
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Chen
mesh_terms: D001599:Berberine / Q000138:chemical synthesis / Q000737:chemistry*; D019281:Dimerization; D005453:Fluorescence; D054856:G-Quadruplexes; D013696:Temperature
chemical_list: D001599:Berberine