title: Acute Inflammatory Response to Low-, Moderate-, and High-Load Resistance Exercise in Women With Breast Cancer-Related Lymphedema.
abstract: Background Resistance exercise is emerging as a potential adjunct therapy to aid in the management of breast cancer-related lymphedema (BCRL). However, the mechanisms underlying the relationships between the acute and long-term benefits of resistance exercise on BCRL are not well understood. Purpose To examine the acute inflammatory response to upper-body resistance exercise in women with BCRL and to compare these effects between resistance exercises involving low, moderate, and high loads. The impact on lymphedema status and associated symptoms was also compared. Methods A total of 21 women, 62 ± 10 years old, with BCRL participated in the study. Participants completed low-load (15-20 repetition maximum [RM]), moderate-load (10-12 RM), and high-load (6-8 RM) exercise sessions consisting of 3 sets of 6 upper-body resistance exercises. Sessions were completed in a randomized order separated by a 7- to 10-day wash-out period. Venous blood samples were obtained to assess markers of exercise-induced muscle damage and inflammation. Lymphedema status was assessed using bioimpedance spectroscopy and arm circumferences, and associated symptoms were assessed using Visual Analogue Scales for pain, heaviness, and tightness. Measurements were conducted before and 24 hours after the exercise sessions. Results No significant changes in creatine kinase, C-reactive protein, interleukin-6, and tumor necrosis factor-α were observed following the 3 resistance exercise sessions. There were no significant changes in arm swelling or symptom severity scores across the 3 resistance exercise conditions. Conclusions The magnitude of acute exercise-induced inflammation following upper-body resistance exercise in women with BCRL does not vary between resistance exercise loads.
authors.affiliation: Australian Catholic University, Melbourne, Victoria, Australia Edith Cowan University, Joondalup, Western Australia, Australia Prue.Cormie@acu.edu.au.
authors.forename: Prue
authors.initials: P
authors.lastname: Cormie
authors.affiliation: Queensland University of Technology, Queensland, Australia.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Singh
authors.affiliation: Queensland University of Technology, Queensland, Australia.
authors.forename: Sandi
authors.initials: S
authors.lastname: Hayes
authors.affiliation: Queensland University of Technology, Queensland, Australia.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Peake
authors.affiliation: Edith Cowan University, Joondalup, Western Australia, Australia.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Galvão
authors.affiliation: Edith Cowan University, Joondalup, Western Australia, Australia University of Wollongong, Wollongong, New South Wales, Australia.
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Taaffe
authors.affiliation: Edith Cowan University, Joondalup, Western Australia, Australia Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
authors.forename: Nigel
authors.initials: N
authors.lastname: Spry
authors.affiliation: Edith Cowan University, Joondalup, Western Australia, Australia.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nosaka
authors.affiliation: Queensland University of Technology, Queensland, Australia.
authors.forename: Bruce
authors.initials: B
authors.lastname: Cornish
authors.affiliation: University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Kathryn H
authors.initials: KH
authors.lastname: Schmitz
authors.affiliation: Edith Cowan University, Joondalup, Western Australia, Australia University of Queensland, Herston, Queensland, Australia.
authors.forename: Robert U
authors.initials: RU
authors.lastname: Newton
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D000072656:Breast Cancer Lymphedema / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D001943:Breast Neoplasms / Q000150:complications* / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D015850:Interleukin-6 / Q000378:metabolism; D008875:Middle Aged; D055070:Resistance Training / Q000379:methods; D017741:Survivors
chemical_list: D014408:Biomarkers, Tumor; D015850:Interleukin-6; D002097:C-Reactive Protein; D003402:Creatine Kinase
keywords: breast cancer; inflammation; lymphedema; resistance exercise; weight training