title: [Profuse sarcoidosis associated with multiple cutaneous squamous cell carcinomas].
abstract: BACKGROUND
  The cutaneous signs of sarcoidosis are polymorphous and occasionally misleading. Herein, we report a rare case of profuse sarcoidosis involving various rare cutaneous signs specific to the disease associated with multiple cutaneous squamous cell carcinomas.
  
  
  METHODS
  A seventy-three-year-old man had been presenting dry ichthyosiform erythroderma for 2 years. The examination also revealed diffuse cutaneous atrophy with ulceration, superficial adenopathy and pseudotumoral hypodermic masses. Ophthalmological examination revealed conjunctival nodules. Biopsy samples for the various cutaneous lesions, salivary glands, conjunctival nodules, a hypodermic nodule and an adenopathy yielded similar images evocative of epithelioid granulomas and giant cells without caseous necrosis. Infectious causes were ruled out. Respiratory function tests showed a restrictive respiratory disorder. ACE levels were extremely high. Proteinuria was noted for 24-hour urine tests and renal punch biopsy showed an appearance of membrane-proliferative glomerulonephritis. Oral corticosteroids produced clinical and laboratory improvement. Furthermore, the patient was also presenting several invasive cutaneous squamous cell carcinomas in a setting of marked helioderma.
  
  
  CONCLUSIONS
  Erythrodermic, ichthyosiform, atrophied, ulcerated and pseudotumoral forms of cutaneous sarcoidosis are very uncommon and their simultaneous appearance in the same patient is extremely rare. Further, the existence of numerous cutaneous carcinomas in this patient raises the question of an association between sarcoidosis and cancer, with fortuitous association appearing unlikely.
authors.affiliation: Service de dermatologie-vénéréologie, CHU Mohammed VI, 40000 Marrakech, Maroc. Electronic address: Fz.ouahidi@gmail.com.
authors.forename: F-E
authors.initials: FE
authors.lastname: Ouahidi
authors.affiliation: Service de dermatologie-vénéréologie, CHU Mohammed VI, 40000 Marrakech, Maroc.
authors.forename: O
authors.initials: O
authors.lastname: Hocar
authors.affiliation: Service de dermatologie-vénéréologie, CHU Mohammed VI, 40000 Marrakech, Maroc.
authors.forename: N
authors.initials: N
authors.lastname: Akhdari
authors.affiliation: Service d'anatomopathologie, CHU Mohammed VI, Marrakech, Maroc.
authors.forename: F-Z
authors.initials: FZ
authors.lastname: Hazmiri
authors.affiliation: Service d'anatomopathologie, CHU Mohammed VI, Marrakech, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Fakhri
authors.affiliation: Service d'anatomopathologie, CHU Mohammed VI, Marrakech, Maroc.
authors.forename: B
authors.initials: B
authors.lastname: Belaabidia
authors.affiliation: Service de chirurgie plastique, CHU Mohammed VI, Marrakech, Maroc.
authors.forename: Y
authors.initials: Y
authors.lastname: Benchemkha
authors.affiliation: Service de chirurgie plastique, CHU Mohammed VI, Marrakech, Maroc.
authors.forename: S
authors.initials: S
authors.lastname: Ettabli
authors.affiliation: Service de néphrologie-hémodialyse, CHU Mohammed VI, Marrakech, Maroc.
authors.forename: O
authors.initials: O
authors.lastname: Fadili
authors.affiliation: Service de néphrologie-hémodialyse, CHU Mohammed VI, Marrakech, Maroc.
authors.forename: I
authors.initials: I
authors.lastname: Louad
authors.affiliation: Service de dermatologie-vénéréologie, CHU Mohammed VI, 40000 Marrakech, Maroc.
authors.forename: S
authors.initials: S
authors.lastname: Amal
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D012507:Sarcoidosis / Q000150:complications*; D012871:Skin Diseases / Q000150:complications*; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology
keywords: Carcinome épidermoïde cutané; Cutaneous squamous cell carcinoma; Glomérulonéphrite membranoproliférative; Membranoproliferative glomerulonephritis; Sarcoidosis; Sarcoïdose