title: The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking.
abstract: The extracellular matrix in the healthy breast has an important tumor suppressive role, whereas the abnormal ECM in tumors can promote aggressiveness, and has been linked to breast cancer relapse, survival and resistance to chemotherapy. This review article gives an overview of the elements of the ECM which have been linked to prognosis of breast cancers, including changes in ECM protein composition, splicing, and microstructure.
authors.affiliation: Lawrence Berkeley National Lab, 1 Cyclotron Rd. MS 977, Berkeley, CA 94720, United States. Electronic address: Crobertson@lbl.gov.
authors.forename: Claire
authors.initials: C
authors.lastname: Robertson
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D005109:Extracellular Matrix / Q000473:pathology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D011379:Prognosis; D012326:RNA Splicing
chemical_list: D016326:Extracellular Matrix Proteins
keywords: Breast cancer; Extracellular matrix; Microstructure; Splicing