title: Live birth resulting from a conjoined oocyte confirmed as euploid using array CGH: a case report.
abstract: The significance of conjoined oocytes in the clinical IVF laboratory setting has been of question due to the extremely limited data available. The most reliable criterion for true binovularity is the inclusion of two oocytes within a common zona pellucida or their fusion in the zonal region. This is a relatively rare event and owing to the limited number of embryo transfers performed and information on their outcomes, it is highly probable that these oocytes would be discarded without attempts at fertilization and subsequent embryo culture. To our knowledge, this is the first reported pregnancy resulting from a conjoined oocyte. Our experience involved a blastocyst transfer of a genetically screened embryo, performed after removal of the germinal vesicle from the conjoined oocyte/embryo on day 3. A clinical pregnancy with a gestational sac and fetal heartbeat was achieved and a healthy baby girl was delivered via Caesarean section at 37 weeks' gestation.
authors.affiliation: IVF Australia, Level 1, 225 Maroubra Rd, Maroubra, NSW 2035, Australia. Electronic address: Lisa.Cummins@ivf.com.au.
authors.forename: Lisa
authors.initials: L
authors.lastname: Cummins
authors.affiliation: IVF Australia, Level 1, 225 Maroubra Rd, Maroubra, NSW 2035, Australia.
authors.forename: Juliette
authors.initials: J
authors.lastname: Koch
authors.affiliation: IVF Australia, Level 1, 225 Maroubra Rd, Maroubra, NSW 2035, Australia.
authors.forename: Suha
authors.initials: S
authors.lastname: Kilani
mesh_terms: D000328:Adult; D055028:Comparative Genomic Hybridization; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D054315:Oocyte Retrieval / Q000009:adverse effects; D009865:Oocytes / Q000473:pathology*; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods
keywords: IVF; binovular follicle; conjoined oocyte