title: Antitoxic Activity of Extract from Salix Viminalis Leaves under Conditions of 5-Fluorouracil Treatment.
abstract: Injection of 5-fluorouracil to animals caused a pronounced toxic effect. Therapeutic and preventive treatment with Salix viminalis leaf extract significantly reduced the negative effects of the antitumor drug: promoted recovery of the bone marrow, peripheral blood, and visceral parameters and prevented ulceration. Combined use of the cytostatic and Salix viminalis extract increased the efficiency of antitumor therapy.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. sv.ak@mail.ru.
authors.forename: S G
authors.initials: SG
authors.lastname: Aksinenko
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: T N
authors.initials: TN
authors.lastname: Povet'eva
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nesterova
authors.affiliation: National Research Tomsk State University, Tomsk, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Kharina
authors.affiliation: National Research Tomsk State University, Tomsk, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Kravtsova
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use / Q000633:toxicity*; D001772:Blood Cell Count; D001853:Bone Marrow / Q000187:drug effects; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000556:secondary; D054697:Cytostatic Agents / Q000627:therapeutic use / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D000431:Ethanol; D005472:Fluorouracil / Q000627:therapeutic use / Q000633:toxicity*; D006402:Hematologic Diseases / Q000139:chemically induced / Q000517:prevention & control; D006410:Hematopoiesis / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D032108:Salix / Q000737:chemistry*; D012997:Solvents; D013163:Splenomegaly / Q000139:chemically induced / Q000517:prevention & control; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D014781:Viscera / Q000187:drug effects
chemical_list: D000964:Antimetabolites, Antineoplastic; D054697:Cytostatic Agents; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D005472:Fluorouracil
keywords: 5-fluorouracil; Lewis’ lung carcinoma; Salix viminalis; antitumor therapy; cytoprotective effect