title: Retargeted oncolytic viruses provoke tumor-directed T-cell responses.
abstract: Intratumoral application of oncolytic viruses effectively induce tumor-directed immune responses. However, their systemic application is typically insufficient to stimulate the required extent of tumor tissue inflammation to elicit antitumor immunity. We recently discovered evidence that this barrier can be overcome by effective molecular retargeting of viral infection.
authors.affiliation: Clinic of Gastroenterology; Hepatology and Endocrinology; Hannover Medical School ; Hannover, Germany ; Department of Hematology; Hemostasis; Oncology and Stem Cell Transplantation; Hannover Medical School ; Hannover, Germany.
authors.forename: Arnold
authors.initials: A
authors.lastname: Kloos
authors.affiliation: Clinic of Gastroenterology; Hepatology and Endocrinology; Hannover Medical School ; Hannover, Germany.
authors.forename: Norman
authors.initials: N
authors.lastname: Woller
authors.affiliation: Institute of Cellular Chemistry; Hannover Medical School ; Hannover, Germany.
authors.forename: Rita
authors.initials: R
authors.lastname: Gerardy-Schahn
authors.affiliation: Clinic of Gastroenterology; Hepatology and Endocrinology; Hannover Medical School ; Hannover, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Kühnel
keywords: oncolytic virus, molecular retargeting, neoepitope-specific T cell responses