title: [Genetic polymorphism of cytochrome P450 2E1 and the risk of nasopharyngeal carcinoma].
abstract: Cytochrome P450 2E1 (CYP2E1) is a detoxifying enzyme that belongs to the phase I metabolism of xenobiotics. This enzyme is encoded by a highly polymorphic gene whose common polymorphism corresponds to the substitution of cytosine (C) and thymine (T) at position -1019 (rs2031920). This polymorphism has been identified in several cancers including nasopharyngeal cancer (NPC). The study involved 124 patients with nasopharyngeal carcinoma, compared with 166 healthy controls. The presence or absence of the polymorphism is determined by PCR-RFLP. The frequency comparison between the two groups is determined by the χ(2) test. The analysis of our results showed a significant difference between the two groups regarding the mutant genotype (C2/C2) (5% vs. 0.5%, P=0.04) and has a risk factor for NPC in Tunisia (OR=8.39; CI 95% [0.99-388.1]). Also, the C2 allele was significantly associated with the group of patients than the control group (6% vs. 2%, P=0.016) and increased three times the risk of NPC in Tunisia (OR=2.99, CI 95% [1.12-8.79]). Our results confirm the results reported in other populations and emphasize the importance of the involvement of this gene in the development of detoxification of the NPC, which seems more and more strongly associated with environmental factors.
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie. Electronic address: arijnour_06@yahoo.fr.
authors.forename: Arij
authors.initials: A
authors.lastname: Ben Chaaben
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie.
authors.forename: Hajer
authors.initials: H
authors.lastname: Abaza
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie.
authors.forename: Hayet
authors.initials: H
authors.lastname: Douik
authors.affiliation: Institut Pasteur de Tunis, laboratoire d'hématologie moléculaire et cellulaire, Tunis, Tunisie.
authors.forename: Leila
authors.initials: L
authors.lastname: Chaouch
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie.
authors.forename: Fayza
authors.initials: F
authors.lastname: Ayari
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie.
authors.forename: Nesrine
authors.initials: N
authors.lastname: Ouni
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie.
authors.forename: Tasnim
authors.initials: T
authors.lastname: Mamoghli
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie.
authors.forename: Dorra
authors.initials: D
authors.lastname: Ben Guezella
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie.
authors.forename: Rachida
authors.initials: R
authors.lastname: Mejri
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie.
authors.forename: Latifa
authors.initials: L
authors.lastname: Harzallah
authors.affiliation: Institut Salah Azaiz, laboratoire de biologie Clinique, Tunis, Tunisie.
authors.forename: Fethi
authors.initials: F
authors.lastname: Guemira
mesh_terms: D000328:Adult; D000483:Alleles; D002277:Carcinoma; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008297:Male; D009154:Mutation; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012306:Risk; D014416:Tunisia
chemical_list: D019392:Cytochrome P-450 CYP2E1
keywords: Carcinome du nasopharynx; Cytochrome P450 2E1; Detoxication; Détoxication; Genetic polymorphism; Nasopharyngeal carcinoma; Polymorphisme génétique