title: Borrelia miyamotoi Disease: Neither Lyme Disease Nor Relapsing Fever.
abstract: Borrelia miyamotoi disease (BMD) is a newly recognized borreliosis globally transmitted by ticks of the Ixodes persulcatus species complex. Once considered to be a tick symbiont with no public health implications, B miyamotoi is increasingly recognized as the agent of a nonspecific febrile illness often misdiagnosed as acute Lyme disease without rash, or as ehrlichiosis. The frequency of its diagnosis in the northeastern United States is similar to that of human granulocytic ehrlichiosis. A diagnosis of BMD is confirmed by polymerase chain reaction analysis of acute blood samples, or by seroconversion using a recombinant glycerophosphodiester phosphodiesterase enzyme immunoassay. BMD is successfully treated with oral doxycycline or amoxicillin.
authors.affiliation: Department of Infectious Disease and Global Health, Tufts University, Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA. Electronic address: sam.telford@tufts.edu.
authors.forename: Sam R
authors.initials: SR
authors.lastname: Telford
authors.affiliation: Department of Infectious Disease and Global Health, Tufts University, Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA.
authors.forename: Heidi K
authors.initials: HK
authors.lastname: Goethert
authors.affiliation: Imugen, Inc., 315 Norwood Park South, Norwood, MA 02062, USA.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Molloy
authors.affiliation: Imugen, Inc., 315 Norwood Park South, Norwood, MA 02062, USA.
authors.forename: Victor P
authors.initials: VP
authors.lastname: Berardi
authors.affiliation: Hawthorn Medical Associates, 275 Allen Street, Unit 3, New Bedford, MA 02740, USA.
authors.forename: Hanumara Ram
authors.initials: HR
authors.lastname: Chowdri
authors.affiliation: Hunterdon Medical Center Infectious Diseases, 1100 Wescott Drive, Suite 306, Flemington, NJ 08822, USA.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Gugliotta
authors.affiliation: Nantucket Cottage Hospital, 57 Prospect Street, Nantucket, MA 02554, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Lepore
mesh_terms: D000368:Aged; D001899:Borrelia Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D005260:Female; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction
keywords: Borrelia miyamotoi; Borreliosis; Deer ticks; Lyme disease; Zoonotic infection