title: Antibody Array as a Tool for Screening of Natural Agents in Cancer Chemoprevention.
abstract: The efficacy of a given drug resides mainly on its ability to specifically target disease mechanisms. Natural products represent the leading source of bioactive molecules with a broad range of activities. It is becoming increasingly clear that natural compounds exert their chemopreventive or antitumoral activities targeting simultaneously diverse cellular pathways. Here we describe the use of antibody array to assess the effects of natural compounds on the expression of multiple proteins and of their posttranslational modifications in cellular systems. This might turn to be a very flexible application for cancer chemoprevention studies.
authors.affiliation: Molecular Chemoprevention Unit, Molecular Medicine Area, Italian National Cancer Institute "Regina Elena", via Elio Chianesi, 53, Rome, 00144, Italy. c.pulito@ifo.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Pulito
authors.affiliation: Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sacconi
authors.affiliation: Molecular Chemoprevention Unit, Molecular Medicine Area, Italian National Cancer Institute "Regina Elena", via Elio Chianesi, 53, Rome, 00144, Italy.
authors.forename: Etleva
authors.initials: E
authors.lastname: Korita
authors.affiliation: Aboca SpA Società Agricola, Sansepolcro, Tuscany, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Maidecchi
authors.affiliation: Molecular Chemoprevention Unit, Molecular Medicine Area, Italian National Cancer Institute "Regina Elena", via Elio Chianesi, 53, Rome, 00144, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Strano
mesh_terms: D000906:Antibodies / Q000276:immunology*; D001688:Biological Products / Q000627:therapeutic use*; D018890:Chemoprevention; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D009369:Neoplasms / Q000517:prevention & control*; D040081:Protein Array Analysis / Q000379:methods*; D013194:Staining and Labeling
chemical_list: D000906:Antibodies; D001688:Biological Products
keywords: Antibody array; Cancer chemoprevention; Natural agent