title: Regulation of macrophage development and function in peripheral tissues.
abstract: Macrophages are immune cells of haematopoietic origin that provide crucial innate immune defence and have tissue-specific functions in the regulation and maintenance of organ homeostasis. Recent studies of macrophage ontogeny, as well as transcriptional and epigenetic identity, have started to reveal the decisive role of the tissue stroma in the regulation of macrophage function. These findings suggest that most macrophages seed the tissues during embryonic development and functionally specialize in response to cytokines and metabolites that are released by the stroma and drive the expression of unique transcription factors. In this Review, we discuss how recent insights into macrophage ontogeny and macrophage-stroma interactions contribute to our understanding of the crosstalk that shapes macrophage function and the maintenance of organ integrity.
authors.affiliation: Department of Oncological Sciences, Tisch Cancer Institute and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, New York 10029, USA.
authors.forename: Yonit
authors.initials: Y
authors.lastname: Lavin
authors.affiliation: Department of Oncological Sciences, Tisch Cancer Institute and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, New York 10029, USA.
authors.forename: Arthur
authors.initials: A
authors.lastname: Mortha
authors.affiliation: Department of Oncological Sciences, Tisch Cancer Institute and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, New York 10029, USA.
authors.forename: Adeeb
authors.initials: A
authors.lastname: Rahman
authors.affiliation: Department of Oncological Sciences, Tisch Cancer Institute and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, New York 10029, USA.
authors.forename: Miriam
authors.initials: M
authors.lastname: Merad
mesh_terms: D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004622:Embryo, Mammalian / Q000098:blood supply / Q000166:cytology / Q000276:immunology*; D006410:Hematopoiesis / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism; D018448:Models, Immunological; D009928:Organ Specificity / Q000276:immunology; D014157:Transcription Factors / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D008565:Membrane Proteins; D014157:Transcription Factors