title: Adherence to a predefined vaccination program in patients with inflammatory bowel disease.
abstract: BACKGROUND
  The application of vaccination programs in patients with inflammatory bowel disease (IBD) is heterogeneous and generally deficient. As a result, adherence in these patients to a predefined vaccination program has not been clearly established. The aim of this study was to estimate adherence to a predefined vaccination program among patients with IBD and to identify the factors that may predict poor adherence.
  
  
  METHODS
  All patients diagnosed with IBD and followed-up between January and March 2012 were referred to the Department of Preventive Medicine for evaluation of their immune status (with serological testing for hepatitis A, B and C viruses, varicella-zoster virus, mumps, rubella and measles), followed by vaccination based on the test results obtained and on the patient's vaccination history. The percentage of adherence to the vaccination program was determined, along with the factors associated with low adherence.
  
  
  RESULTS
  A total of 153 patients with IBD (ulcerative colitis in 50.3% and Crohn's disease in 49.7%) were included (45.1% men and 54.9% women; mean age 43.30±14.19 years, range 17-83). The vaccination program adherence rate was 84.3%. The factors associated with poor adherence were drugs related to IBD (patients not receiving immunosuppressants and/or biological agents showed lower adherence than those receiving these treatments; p=0.021), adherence to medical treatment (poor adherence to treatment was also associated with poor adherence to vaccination; p=0.016), and marital status (single, divorced or separated patients showed lower adherence than married individuals; p=0.015).
  
  
  CONCLUSIONS
  Adherence to vaccination is acceptable among patients with IBD. However, specific actions, such as optimization of patient information on the disease and emphasis on the need for adequate vaccination, are to improve adherence.
authors.affiliation: Department of Gastroenterology of Reina Sofía University Hospital, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain. Electronic address: patriciaruizcuesta@hotmail.com.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ruiz-Cuesta
authors.affiliation: Department of Gastroenterology of Reina Sofía University Hospital, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: González-Alayón
authors.affiliation: Department of Gastroenterology of Reina Sofía University Hospital, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Jurado-García
authors.affiliation: Department of Gastroenterology of Reina Sofía University Hospital, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Iglesias-Flores
authors.affiliation: Department of Preventive Medecine, Reina Sofía University Hospital, Córdoba, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Barranco-Quintana
authors.affiliation: Department of Gastroenterology of Reina Sofía University Hospital, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain.
authors.forename: Luisa
authors.initials: L
authors.lastname: García-García
authors.affiliation: Department of Gastroenterology of Reina Sofía University Hospital, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain.
authors.forename: Isabel M
authors.initials: IM
authors.lastname: Salgueiro-Rodríguez
authors.affiliation: Department of Gastroenterology of Reina Sofía University Hospital, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Benitez-Cantero
authors.affiliation: Department of Gastroenterology of Reina Sofía University Hospital, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain.
authors.forename: Valle
authors.initials: V
authors.lastname: García-Sánchez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001685:Biological Factors / Q000627:therapeutic use; D015897:Comorbidity; D005260:Female; D015438:Health Behavior; D006801:Humans; D007115:Immunization Schedule; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000276:immunology / Q000523:psychology*; D008297:Male; D008393:Marriage; D008875:Middle Aged; D010349:Patient Compliance; D011446:Prospective Studies; D014611:Vaccination / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D001685:Biological Factors; D007166:Immunosuppressive Agents
keywords: Adherence; Adherencia; Enfermedad inflamatoria intestinal; Inflammatory bowel disease; Vaccination; Vacunación