title: The YPEL5-PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples.
abstract: Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5-PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5-PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.
authors.affiliation: Laboratory for Molecular Diagnostics-Hematology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
authors.forename: Karl
authors.initials: K
authors.lastname: Vandepoele
authors.affiliation: Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Philippé
authors.affiliation: Laboratory for Molecular Diagnostics-Hematology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
authors.forename: Barbara
authors.initials: B
authors.lastname: Denys
keywords: Chronic lymphocytic leukemia; Trans-splicing; YPEL5–PPP1CB