title: Randomized Clinical Trial of Intraosseous Methylprednisolone Injection for Acute Pulpitis Pain.
abstract: BACKGROUND
  The present study reports the results of a randomized clinical trial comparing local intraosseous methylprednisolone injection and emergency pulpotomy in the management of acute pulpitis on efficacy, safety, and efficiency end points.
  
  
  METHODS
  After providing prior informed written consent, 94 patients consulting for acute irreversible pulpitis pain at university-affiliated teaching hospital dental clinics in Dakar, Senegal were randomly assigned to either the methylprednisolone treatment group (n = 47) or the pulpotomy treatment group (n = 47). Patients were followed up at 1 week and assessed 6 months later to evaluate the therapeutic outcome of their treatment.
  
  
  RESULTS
  At day 7 the patients in the methylprednisolone group reported less intense spontaneous and percussion pain in the day 0-day 7 period than the patients in the pulpotomy group. Methylprednisolone treatment took approximately 7 minutes (4.6-9.3) less to accomplish than pulpotomy (or about half the time). No difference in the therapeutic outcome was found between the 2 treatment groups at 6 months (all credible intervals span 0).
  
  
  CONCLUSIONS
  This study establishes that methylprednisolone injection for acute pulpitis is relieved by a minimally invasive pharmacologic approach more effectively than by the reference pulpotomy and conserves scarce dental resources (ie, endodontic equipment and supplies, dental surgeon's time).
authors.affiliation: Service d'Odontologie Conservatrice et Endodontie, Département d'Odontologie, Faculté de Médecine, Pharmacie et d'Odonto-Stomatologie, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal.
authors.forename: Khaly
authors.initials: K
authors.lastname: Bane
authors.affiliation: Secrétariat Scientifique du CEDIT-PIVT, Assistance Publique-Hôpitaux de Paris, Paris, France; Service d'Odontologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. Electronic address: emmanuel.charpentier@sap.aphp.fr.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Charpentier
authors.affiliation: Service d'Odontologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France; UFR d'Odontologie, Université Denis Diderot, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Bronnec
authors.affiliation: Service d'Odontologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France; UFR d'Odontologie, Université Denis Diderot, Paris, France.
authors.forename: Vianney
authors.initials: V
authors.lastname: Descroix
authors.affiliation: Service d'Odontologie Conservatrice et Endodontie, Département d'Odontologie, Faculté de Médecine, Pharmacie et d'Odonto-Stomatologie, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal.
authors.forename: Fatou
authors.initials: F
authors.lastname: Gaye-N'diaye
authors.affiliation: Service d'Odontologie Conservatrice et Endodontie, Département d'Odontologie, Faculté de Médecine, Pharmacie et d'Odonto-Stomatologie, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal.
authors.forename: Abdoul Wahabe
authors.initials: AW
authors.lastname: Kane
authors.affiliation: Service d'Odontologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: Rafael
authors.initials: R
authors.lastname: Toledo
authors.affiliation: Service d'Odontologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France; UFR d'Odontologie, Université Denis Diderot, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Machtou
authors.affiliation: Service d'Odontologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France; UFR d'Odontologie, Université Denis Diderot, Paris, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Azérad
mesh_terms: D000208:Acute Disease; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008775:Methylprednisolone / Q000008:administration & dosage*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D011671:Pulpitis / Q000503:physiopathology*; D011672:Pulpotomy; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone
keywords: Emergency treatment; endodontics; pain management; pulpitis