title: Molecular mechanisms of etoposide.
abstract: Etoposide derives from podophyllotoxin, a toxin found in the American Mayapple. It was first synthesized in 1966 and approved for cancer therapy in 1983 by the U.S. Food and Drug Administration (Hande, 1998[25]). Starting from 1980s several studies demonstrated that etoposide targets DNA topoisomerase II activities thus leading to the production of DNA breaks and eliciting a response that affects several aspects of cell metabolisms. In this review we will focus on molecular mechanisms that account for the biological effect of etoposide.
authors.affiliation: Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, Pavia.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Montecucco
authors.affiliation: Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, Pavia ; Dipartimento di Biologia e Biotecnologia, Università degli Studi di Pavia, via Ferrata 9, Pavia, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Zanetta
authors.affiliation: Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, Pavia.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Biamonti