title: Acquired coagulation factor XIII deficiency: a case report.
abstract: The main objective of the study is to summarize the clinical characteristics of acquired factor XIII (FXIII) deficiency caused by a spontaneous FXIII inhibitor. Here we report a new case of acquired FXIII deficiency caused by FXIII inhibitor and review the medical literature regarding the characteristics and treatment of this disorder. FXIII deficiency caused by FXIII inhibitors is rare and of uncertain pathogenesis. Experience with therapeutic measures is limited to data from case reports. Immunosuppressive drugs may reduce autoantibodies or inhibit the cell clone generating the antibodies and may have been of benefit in our patient. The impact of such therapy on patient prognosis is incompletely known.
authors.affiliation: Department of Hematology, Jinhua Hospital of Zhejiang University, Jinhua, China.
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Jia
authors.forename: Huixian
authors.initials: H
authors.lastname: Hu
authors.forename: Bin
authors.initials: B
authors.lastname: Wei
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000187:drug effects; D001379:Azathioprine / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D005176:Factor XIII / Q000378:metabolism; D005177:Factor XIII Deficiency / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy* / Q000276:immunology; D006406:Hematoma / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D005176:Factor XIII; D001379:Azathioprine; D011241:Prednisone