title: Clinical guideline seom: hereditary colorectal cancer.
abstract: Genetic mutations have been identified as the cause of inherited cancer risk in some colon cancer; these mutations are estimated to account for only 5-6 % of colorectal cancer (CRC) cases overall. Up to 25-30 % of patients have a family history of CRC that suggests a hereditary component, common exposures among family members, or a combination of both. Cancers in people with a hereditary predisposition typically occur at an earlier age than in sporadic cases. A predisposition to CRC may include a predisposition to other cancers, such as endometrial cancer. We describe genetics, current diagnosis and management of CRC hereditary syndromes pointing to a multidisciplinary approach to achieve the best results in patients and family outcomes.
authors.affiliation: Medical Oncology Department, Hospital Universitario Ramón y Cajal, Carretera de Colmenar Viejo, KM 9,100, 28034, Madrid, Spain. carmenguillenponce@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Guillén-Ponce
authors.affiliation: Medical Oncology Department, Hospital Reina Sofía, Córdoba, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Serrano
authors.affiliation: Medical Oncology Department, Hospital General Universitario de Elche, Elche (Alicante), Spain.
authors.forename: A B
authors.initials: AB
authors.lastname: Sánchez-Heras
authors.affiliation: Medical Oncology Department, Instituto Catalán de Oncología (ICO), Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Teulé
authors.affiliation: Medical Oncology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Chirivella
authors.affiliation: Medical Oncology Department, Hospital Universitario de Salamanca, Salamanca, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Martín
authors.affiliation: Medical Oncology Department, Hospital Marqués de Valdecilla, Santander, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Martínez
authors.affiliation: Medical Oncology Department, Hospital La Mancha Centro, Alcázar De San Juan (Ciudad Real), Spain.
authors.forename: R
authors.initials: R
authors.lastname: Morales
authors.affiliation: Medical Oncology Department, Hospital Doce de Octubre, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Robles
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000235:genetics / Q000517:prevention & control*; D055088:Early Detection of Cancer; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic / Q000592:standards*; D055815:Young Adult
keywords: Adenomatous polyposis; Colon cancer; Hereditary colorectal cancer; Lynch syndrome