title: Effect of phenylephrine and terbutaline on ischemic priapism: a retrospective review.
abstract: BACKGROUND
  Ischemic priapism is the most common cause of priapism due to low blood flow. Current guidelines recommend penile aspiration and the use of intracavernous injection of vasoactive agents. The data to support these recommendations are limited and rely on expert consensus.
  
  
  OBJECTIVE
  The objective was to determine the effectiveness of terbutaline and phenylephrine on detumescence of ischemic priapism.
  
  
  METHODS
  This was a retrospective review of patients presenting to the emergency department with a chief concern of priapism who received oral or subcutaneous terbutaline or intracavernous phenylephrine. The primary outcome is successful detumescence. The secondary outcome is drug-related adverse drug events.
  
  
  RESULTS
  A total of 31 cases of ischemic priapism were included, with 8 patients receiving terbutaline and 23 receiving phenylephrine. Of the cases treated with terbutaline, 25% had successful detumescence compared with phenylephrine with a 74% success rate. No drug-related adverse events were reported or identified.
  
  
  CONCLUSIONS
  Patients receiving intracavernous irrigation with phenylephrine were more likely to achieve successful detumescence than those treated with oral or subcutaneous terbutaline.
authors.affiliation: Emergency Medicine, Nyack Hospital, Nyack, NY. Electronic address: Colleenmartin13@gmail.com.
authors.forename: Colleen
authors.initials: C
authors.lastname: Martin
authors.affiliation: Emergency Medicine, Trinity Mother Frances Hospital, Tyler, TX.
authors.forename: Craig
authors.initials: C
authors.lastname: Cocchio
mesh_terms: D058646:Adrenergic alpha-1 Receptor Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D008297:Male; D010413:Penis / Q000098:blood supply; D010656:Phenylephrine / Q000627:therapeutic use*; D011317:Priapism / Q000188:drug therapy*; D012189:Retrospective Studies; D013726:Terbutaline / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D058666:Adrenergic beta-2 Receptor Agonists; D010656:Phenylephrine; D013726:Terbutaline