title: Periodontitis and bone metabolism.
abstract: Periodontitis is a plaque induced disease characterized by tissue destruction. The extent of the alveolar bone loss depends on the host response stimulated by bacterial infection. Recently researchers have focused on the role of the immune system, of RANK/RANKL/OPG pathway and of cytokines network. Another recent field of interest is osteoimmunology that try to explain the relationship between immune and bone cells in activating bone resorption. Advances in the understanding of the pathogenic mechanisms allowed a better understanding of the relationship with other diseases like osteoporosis and also to hypothesize new therapies based on modulation of host response (host modulatory therapy - HMT). The purpose of this mini-review is to briefly discuss these topics.
authors.affiliation: Department of Translational Medicine and Surgery, Section of Dentistry, University of Florence, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Barbato
authors.affiliation: Department of Translational Medicine and Surgery, Section of Dentistry, University of Florence, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Francioni
authors.affiliation: Department of Translational Medicine and Surgery, Section of Dentistry, University of Florence, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Bianchi
authors.affiliation: Department of Translational Medicine and Surgery, Section of Dentistry, University of Florence, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Mascitelli
authors.affiliation: Department of Translational Medicine and Surgery, Section of Dentistry, University of Florence, Italy.
authors.forename: Leila Brancato
authors.initials: LB
authors.lastname: Marco
authors.affiliation: Department of Translational Medicine and Surgery, Section of Dentistry, University of Florence, Italy.
authors.forename: Duvina Paolo
authors.initials: DP
authors.lastname: Tonelli
keywords: alveolar bone; osteoimmunology; osteoporosis; periodontitis