title: Risk factor(s) related to high membrane permeability in peritoneal dialysis.
abstract: OBJECTIVE
  Peritoneal dialysis (PD) patients have different peritoneal membrane permeability (transport) characteristics. High peritoneal membrane permeability is associated with increased mortality risk in the patient population. In this study, we aimed to investigate possible risk factor(s) related to high peritoneal membrane permeability.
  
  
  METHODS
  The study included 475 PD patients (46.1 ± 14.5 years of mean age; 198 female and 277 male). The patients were divided two groups according to peritoneal equilibration test (PET) result: high-permeability group (high and high-average) and low- permeability group (low-average and low).
  
  
  RESULTS
  In both the univariate and multivariate logistic regression analyses, it was found that diabetes mellitus and hypoalbuminemia was significantly associated with high peritoneal membrane permeability [relative risk (RR): 1.90, 95% confidence interval (CI): 1.26-2.86, p: 0.002 and RR: 2.14, 95% CI: 1.44-3.18, p<0.001, respectively].
  
  
  CONCLUSIONS
  Diabetes mellitus and hypoalbuminemia were closely associated with high peritoneal membrane permeability. Diabetic patients had 1.9 times the likelihood of having high permeability. However, the relationship between hypoalbuminemia and high peritoneal permeability appears to be a result rather than cause.
authors.affiliation: a Department of Nephrology , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Unal
authors.affiliation: a Department of Nephrology , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Murat Hayri
authors.initials: MH
authors.lastname: Sipahioglu
authors.affiliation: a Department of Nephrology , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Kocyigit
authors.affiliation: a Department of Nephrology , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Tunca
authors.affiliation: a Department of Nephrology , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Tokgoz
authors.affiliation: a Department of Nephrology , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Oymak
mesh_terms: D015331:Cohort Studies; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D010539:Permeability; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey
keywords: Diabetes mellitus; hypoalbuminemia; peritoneal equilibration test; peritoneal membrane permeability; risk factor