title: ABCA1 rs1883025 polymorphism and risk of age-related macular degeneration.
abstract: OBJECTIVE
  To evaluate the association of the ABCA1 rs1883025 polymorphism and susceptibility to age-related macular degeneration (AMD).
  
  
  METHODS
  A systematic search of the PubMed, EMBASE, and ISI web of science databases was performed to identify eligible published studies without language restrictions up to September 2015. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were estimated under different genetic models using meta-analytic methods. Stratified analysis and sensitivity analysis were performed to explore potential sources of heterogeneity.
  
  
  RESULTS
  A total of 12 articles with 25,445 cases and 36,460 controls were eligible in this meta-analysis. The ABCA1 rs1883025 variant showed significant association with the lower risk of overall AMD under the allelic model (OR= 0.81, 95   %   CI=0.74-0.89). Stratified analysis based on ethnicity demonstrated a strong association between rs1883025 polymorphism and AMD in the Caucasian population, but not in Asian population. For late AMD, the ABCA1 rs1883025 variant was observed to have a significant association with the lower risk of this disease (OR = 0.81, 95 % CI, 0.72-0.91). In early-stage AMD, significant associations of the rs1883025 polymorphism with lower risk of early AMD were observed in different genetic models (OR ranging from 0.45 to 0.65, all P < 0.05).
  
  
  CONCLUSIONS
  The present meta-analysis indicated that the T allelic in rs1883025 variant was significantly associated with the risk of developing AMD, particularly at the early stage. The associations of the ABCA1 locus with AMD risk in various populations need further exploration.
authors.affiliation: School of Public Health, Xi'an Jiao tong University Health Science Center, 76 Yanta West Road, Xi'an, Shaanxi, 710061, China.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Public Health, Xi'an Jiao tong University Health Science Center, 76 Yanta West Road, Xi'an, Shaanxi, 710061, China.
authors.forename: Mingxu
authors.initials: M
authors.lastname: Wang
authors.affiliation: School of Public Health, Xi'an Jiao tong University Health Science Center, 76 Yanta West Road, Xi'an, Shaanxi, 710061, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Han
authors.affiliation: School of Public Health, Xi'an Jiao tong University Health Science Center, 76 Yanta West Road, Xi'an, Shaanxi, 710061, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: School of Public Health, Xi'an Jiao tong University Health Science Center, 76 Yanta West Road, Xi'an, Shaanxi, 710061, China. male@mail.xjtu.edu.cn.
authors.forename: Le
authors.initials: L
authors.lastname: Ma
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1
keywords: ABCA1; Age-related macular degeneration; Polymorphism