title: Visible-Light-Triggered Drug Release from TiO2 Nanotube Arrays: A Controllable Antibacterial Platform.
abstract: In this work, we use a double-layered stack of TiO2 nanotubes (TiNTs) to construct a visible-light-triggered drug delivery system. The key for visible light drug release is a hydrophobic cap on the nanotubes containing Au nanoparticles (AuNPs). The AuNPs allow for a photocatalytic scission of the hydrophobic chain under visible light. To demonstrate this principle, we loaded ampicillin (AMP) into the lower part of the TiO2 nanotube stack, triggered visible-light-induced release, and carried out antibacterial studies. The release from the platform becomes most controllable if the drug is silane-grafted in the hydrophilic bottom layer for drug storage. Thus, visible light photocatalysis can also determine the release kinetics of the active drug from the nanotube wall.
authors.affiliation: College of Sciences, Northeastern University, Shenyang 110004 (China).
authors.forename: Jingwen
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Materials Science, WW4-LKO, University of Erlangen-Nuremberg, Martensstrasse 7, 91058 Erlangen (Germany).
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhou
authors.affiliation: College of Sciences, Northeastern University, Shenyang 110004 (China).
authors.forename: Zhida
authors.initials: Z
authors.lastname: Gao
authors.affiliation: College of Sciences, Northeastern University, Shenyang 110004 (China). yysong@mail.neu.edu.cn.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Song
authors.affiliation: Department of Materials Science, WW4-LKO, University of Erlangen-Nuremberg, Martensstrasse 7, 91058 Erlangen (Germany). schmuki@ww.uni-erlangen.de.
authors.forename: Patrik
authors.initials: P
authors.lastname: Schmuki
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D006046:Gold / Q000737:chemistry; D008027:Light; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes; D013056:Spectrophotometry, Ultraviolet; D014025:Titanium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; C009495:titanium dioxide; D006046:Gold; D000667:Ampicillin; D014025:Titanium
keywords: antibiotics; drug delivery; nanotubes; surface plasmon resonance