title: Sertraline-Associated Cholestasis and Ductopenia Consistent with Vanishing Bile Duct Syndrome.
abstract: An adolescent with depression treated with sertraline developed cholestasis and bile duct paucity, which resolved with medication discontinuation. Vanishing bile duct syndrome is an acquired destruction of interlobular bile ducts. This type of drug-induced liver injury has been associated with other medications and requires practitioners' awareness of potential hepatotoxicity.
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA. Electronic address: conradm@email.chop.edu.
authors.forename: Máire A
authors.initials: MA
authors.lastname: Conrad
authors.affiliation: University of Pennsylvania, Philadelphia, PA.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Cui
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Henry C
authors.initials: HC
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000009:adverse effects*; D001653:Bile Ducts, Intrahepatic / Q000187:drug effects / Q000473:pathology*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D002779:Cholestasis / Q000139:chemically induced*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D020280:Sertraline / Q000009:adverse effects*
chemical_list: D000928:Antidepressive Agents; D020280:Sertraline