title: [Susceptibility of induced sickle in samples of heterozygous hemoglobin S patients (sickle cell trait) suffering diabetes mellitus type 2].
abstract: Hemoglobin S is an abnormal protein that induces morphological changes in erythrocyte in low-oxygen conditions. In Mexico, it is reported that up to 13.7% of the population with mutation in one allele are considered asymptomatic (sickle cell trait). The sickle cell trait and diabetes mellitus are conditions that occur together in more than one million patients worldwide. Both diseases possibly produce microvascular changes in retinopathy and acute chest syndrome. The aim of this study was to evaluate the induction of sickle cells in samples of diabetic patients with sickle cell trait to identify altered red cell parameters. We obtained samples of diabetic patients to determine hemoglobin A1c and S; furthermore, red blood cell biometrics data were analyzed. We found that older men with diabetes were susceptible to generate sickle cells and this correlated with reduced red blood cell count and an increase in media cell volume. In samples of women diabetes, there were no differences. We conclude that samples from patients with sickle cell trait and diabetes can cause sickle cells with high frequency in men, with lower red blood cells count and increased mean corpuscular volume as susceptibility parameters.
authors.affiliation: Departamento de Hematología, Laboratorio Carpermor, México, D.F., México.
authors.forename: Pablo
authors.initials: P
authors.lastname: Díaz-Piedra
authors.affiliation: Facultad de Ciencias Químicas, Universidad Autónoma de Zacatecas, Zacatecas, México.
authors.forename: Alberto Rafael
authors.initials: AR
authors.lastname: Cervantes-Villagrana
authors.affiliation: Departamento de Hematología, Laboratorio Carpermor, México, D.F., México.
authors.forename: Raúl
authors.initials: R
authors.lastname: Ramos-Jiménez
authors.affiliation: Dirección Proyectos e Investigación, Grupo Diagnóstico Médico Proa, México, D.F., México.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Presno-Bernal
authors.affiliation: Departamento de Investigación Clínica, Grupo Diagnóstico Médico Proa, México, D.F., México.
authors.forename: Rodolfo Daniel
authors.initials: RD
authors.lastname: Cervantes-Villagrana
mesh_terms: D048429:Cell Size; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004906:Erythrocyte Count; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006801:Humans; D008297:Male; D008800:Mexico; D012737:Sex Factors; D012805:Sickle Cell Trait / Q000097:blood*
chemical_list: D006442:Glycated Hemoglobin; D006451:Hemoglobin, Sickle; C517652:hemoglobin A1c protein, human