title: Metal-free oxidative cyclization of acetophenones with diamines: a facile access to phenylpyridines.
abstract: An efficient metal-free access to 2- and 3-phenylpyridines via oxidative coupling of acetophenones or phenylacetones with 1,3-diaminopropane has been described. The reaction involves shorter reaction time, excellent yields and a broad substrate scope. The reaction proceeds via the formation of imine, which further undergoes oxidative C-N bond cleavage, C-C bond formation and oxidation to give a pyridine skeleton. The quantum chemical calculations identified the transition state for the reaction and helped in tracing the reaction mechanism.
authors.affiliation: Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India. sbharate@iiim.ac.in and Academy of Scientific & Innovative Research (AcSIR), CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Department of Pharmacoinformatics and Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, Punjab-160062, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Patel
authors.affiliation: Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India. sbharate@iiim.ac.in and Academy of Scientific & Innovative Research (AcSIR), CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India.
authors.forename: Ram A
authors.initials: RA
authors.lastname: Vishwakarma
authors.affiliation: Department of Pharmacoinformatics and Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, Punjab-160062, India.
authors.forename: Prasad V
authors.initials: PV
authors.lastname: Bharatam
authors.affiliation: Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India. sbharate@iiim.ac.in and Academy of Scientific & Innovative Research (AcSIR), CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India.
authors.forename: Sandip B
authors.initials: SB
authors.lastname: Bharate