title: Measurement of nasal and fractional exhaled nitric oxide in children with upper airway inflammatory disease: Preliminary results.
abstract: OBJECTIVE
  To assess the clinical significance of nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with upper airway inflammatory disease.
  
  
  METHODS
  Fifteen healthy children, 30 with allergic rhinitis (AR), 10 with non-allergic rhinitis (NAR), and 30 with sleep disordered breathing (SDB) were enrolled. The FeNO and nNO concentrations were measured non-invasively using a NIOX MINO system.
  
  
  RESULTS
  Both nNO and FeNO were significantly higher in children with AR than in healthy children (P=0.000 and P=0.000, respectively). Compared to healthy children, nNO was also significant higher in children with NAR (P=0.011) or SDB (P=0.027). In contrast, FeNO did not differ from controls in children with NAR or SDB.
  
  
  CONCLUSIONS
  Our data suggest that nNO has potential value for diagnosing upper airway inflammation. Moreover, elevated FeNO distinguishes allergic from non-allergic rhinitis.
authors.affiliation: Department of Otolaryngology, Guangzhou Women and Children's Medical Centre, The Affiliated Hospital of Guangzhou Medical University, No. 318 Renmin Zhong Road, Guangzhou 510115, Guangdong, China. Electronic address: gzdaboliu@126.com.
authors.forename: Dabo
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Otolaryngology, Guangzhou Women and Children's Medical Centre, The Affiliated Hospital of Guangzhou Medical University, No. 318 Renmin Zhong Road, Guangzhou 510115, Guangdong, China.
authors.forename: Zhenyun
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Otolaryngology, Guangzhou Women and Children's Medical Centre, The Affiliated Hospital of Guangzhou Medical University, No. 318 Renmin Zhong Road, Guangzhou 510115, Guangdong, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Otolaryngology, Guangzhou Women and Children's Medical Centre, The Affiliated Hospital of Guangzhou Medical University, No. 318 Renmin Zhong Road, Guangzhou 510115, Guangdong, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Yi
authors.affiliation: Department of Otolaryngology, Guangzhou Women and Children's Medical Centre, The Affiliated Hospital of Guangzhou Medical University, No. 318 Renmin Zhong Road, Guangzhou 510115, Guangdong, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D001944:Breath Tests; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D012220:Rhinitis / Q000175:diagnosis / Q000378:metabolism; D065631:Rhinitis, Allergic / Q000175:diagnosis / Q000378:metabolism*; D012891:Sleep Apnea Syndromes / Q000378:metabolism
chemical_list: D009569:Nitric Oxide
keywords: Allergic rhinitis; Fractional exhaled nitric oxide; Nasal nitric oxide; Sleep disordered breathing