title: The Gut-Liver Axis in Primary Sclerosing Cholangitis.
abstract: Dysregulation of the key genetic, immunologic, and microbiome compounds of the gut-liver axis is the basis for inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC). This creates opportunities to accelerate therapies that have been traditionally developed for IBD to be used in PSC to the benefit of both diseases. Shared genetic susceptibility loci has yielded important clues into the pathogenesis of PSC-IBD. Understanding of the critical links between PSC and IBD are essential in designing clinical care pathways for these complex patients.
authors.affiliation: Division of Gastroenterology and Hepatology, Health Research and Innovation Centre (HRIC), Snyder Institute for Chronic Diseases, University of Calgary, 4AC66 - 3280 Hospital Drive Northwest, Calgary, Alberta T2N 4N1, Canada. Electronic address: b.eksteen@ucalgary.ca.
authors.forename: Bertus
authors.initials: B
authors.lastname: Eksteen
mesh_terms: D015209:Cholangitis, Sclerosing / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology*; D016207:Cytokines / Q000378:metabolism*; D005647:Fucosyltransferases / Q000235:genetics; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D020022:Genetic Predisposition to Disease; D017228:Hepatocyte Growth Factor / Q000235:genetics; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D007376:Interleukin-2 / Q000235:genetics; D053645:Interleukin-2 Receptor alpha Subunit / Q000235:genetics; D058990:Molecular Targeted Therapy; D019449:Pouchitis / Q000209:etiology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D016207:Cytokines; D005647:Fucosyltransferases; D017228:Hepatocyte Growth Factor; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D014409:Tumor Necrosis Factor-alpha; D000097631:Galactoside 2-alpha-L-fucosyltransferase; C082332:macrophage stimulating protein; C551842:salt-inducible kinase-2, human
keywords: Cholangiocarcinoma; Genetics; Inflammatory bowel disease; Microbiome; Pouchitis; Primary sclerosing cholangitis; Vedolizumab