title: Parity and Risk of Coronary Heart Disease in Middle-aged and Older Chinese Women.
abstract: Pregnancy leads to physiological changes in lipid, glucose levels, and weight, which may increase the risk of coronary heart disease (CHD) in later life. The purpose of this study was to examine whether parity is associated with CHD in middle-aged and older Chinese women. A total of 20,207 women aged 37 to 94 years from Dongfeng-Tongji Cohort who completed the questionnaire, were medically examined and provided blood samples, were included in our analysis. CHD cases were determined by self-report of physician diagnosis through face-to-face interviews. Logistic regression models were used to estimate the association between parity and CHD. The rate of CHD was 15.8%. Parity had a positive association with CHD without adjustment of covariates. After controlling for the potential confounders, increasing risk of coronary heart disease was observed in women who had two (OR, 1.65; 95% CI, 1.41-1.93), three (OR, 1.76; 95% CI, 1.44-2.16), and four or more live births (OR, 1.71; 95% CI, 1.33-2.20) compared with women with just one live birth. High parity was significantly associated with increasing risk of CHD in Chinese women. This suggests that multiparity may be a risk factor for CHD among Chinese women.
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Shen
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.
authors.forename: Guiqiang
authors.initials: G
authors.lastname: Xu
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Song
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.
authors.forename: Siyi
authors.initials: S
authors.lastname: Yang
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Social Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430030, China.
authors.forename: Youjie
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D010298:Parity; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors