title: A Split-Face Study of Dual-Wavelength Laser on Neck and Facial Port-Wine Stains in Chinese Patients.
abstract: BACKGROUND
  Although pulsed dye laser (PDL) has long been regarded as the gold standard in treating port-wine stain (PWS), advanced PWS with deeper coloration may display resistance because of limited penetration depth of 585 or 595-nm light. Recently, a dual-wavelength laser system has been reported to achieve pronounced fading in many patients.
  
  
  OBJECTIVE
  The objective was to evaluate the efficacy and safety of a dual-wavelength laser device in treatment of neck and facial PWS in a direct side-by-side comparison.
  
  
  METHODS
  Sixteen Chinese patients with neck and/or facial PWSs were enrolled in the study. All lesions were randomly divided into two area, treated area and adjacent untreated area. Five successive treatments using a dual-wavelength laser system (595-nm PDL combined with 1,064-nm Nd:YAG laser) were delivered on treated areas at 4- to 6-week intervals. The adjacent area was not treated as self control. Two blinded dermatologists evaluated the clinical changes by comparing the before and after photos. Erythema index (EI) values were measured with a non-invasive instrument.
  
  
  RESULTS
  After five sessions of treatment, over 62.5% (10/16) patients achieved more than 50% (moderate or significant) improvement. The efficacy maintained at the 3-month follow-up visit. The values of EI on treated area showed a significant decrease. Adverse effects of treated area were limited.
  
  
  CONCLUSIONS
  Using this split-face module, the dual-wavelength laser system is proved to be effective and well tolerated in treating neck and facial PWSs in Chinese patients. Adverse effects were minimal and acceptable.
authors.forename: Han-deng
authors.initials: HD
authors.lastname: Tu
authors.forename: Yuan-hong
authors.initials: YH
authors.lastname: Li
authors.forename: Hong-fu
authors.initials: HF
authors.lastname: Xie
authors.forename: Jia-mei
authors.initials: JM
authors.lastname: Xiong
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Xue-gang
authors.initials: XG
authors.lastname: Xu
authors.forename: La-ga
authors.initials: LG
authors.lastname: Tong
authors.forename: Michael H
authors.initials: MH
authors.lastname: Gold
authors.forename: Hong-duo
authors.initials: HD
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D004890:Erythema / Q000453:epidemiology; D005145:Face; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D054025:Lasers, Dye / Q000009:adverse effects / Q000627:therapeutic use*; D053844:Lasers, Solid-State / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009333:Neck; D019339:Port-Wine Stain / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome; D055815:Young Adult