title: Antischistosomal and Cytotoxic Effects of the Essential Oil of Tetradenia riparia (Lamiaceae).
abstract: This paper reports on the antischistosomal and cytotoxic effects of the essential oil obtained from Tetradenia riparia leaves (TR-EO). At concentrations of 50 and 100 µg/mL, TR-EO killed all the worms after 120 and 24 h of incubation, respectively. At a concentration equal to or higher than 50 µg/mL, this oil also separated the coupled pairs and decreased the adult worm motor activity after incubation periods higher than 72 h. In addition, at 120 h of incubation, TR-EO slightly decreased the number of eggs produced by Schistosoma mansoni adult worms and significantly reduced the percentage of developed eggs, in a dose-dependent manner. XTT-colorimetric assays showed that the tested TR-EO concentrations were not considerably cytotoxic to V79 cells (IC50 = 253.5 µg/mL). The effects of TR-EO on egg development were noteworthy; therefore, this essential oil deserves further investigation to identify the chemical constituents that elicit activity against S. mansoni.
authors.forename: Nathalya I
authors.initials: NI
authors.lastname: de Melo
authors.forename: André L L
authors.initials: AL
authors.lastname: Mantovani
authors.forename: Pollyanna F
authors.initials: PF
authors.lastname: de Oliveira
authors.forename: Milton
authors.initials: M
authors.lastname: Groppo
authors.forename: Ademar A Da Silva
authors.initials: AA
authors.lastname: Filho
authors.forename: Vanderlei
authors.initials: V
authors.lastname: Rodrigues
authors.forename: Wilson R
authors.initials: WR
authors.lastname: Cunha
authors.forename: Denise C
authors.initials: DC
authors.lastname: Tavares
authors.forename: Lizandra G
authors.initials: LG
authors.lastname: Magalhães
authors.forename: Antônio E M
authors.initials: AE
authors.lastname: Crottii
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D019686:Lamiaceae / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D012556:Schistosomicides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile; D010938:Plant Oils; D012556:Schistosomicides