title: HUMAN SUBCUTANEOUS DIROFILARIASIS - CASE REPORT.
abstract: BACKGROUND
  Human dirofilariasis is a zoonotic disease caused by Dirofilaria repens and Dirofilaria immitis. It usually presents as a nodular lesion in the lung, subcutaneous tissues or eyes. In animals, dirofilariasis is a very common disease with serious cardiovascular and respiratory manifestations. If adequate therapy is not given at the beginning ofthe disease, dirofilariasis can lead to animal death. On the contrary, human dirofilariasis is frequently mild, sporadic and asymptomatic disease. Complications in humans are very rare. In Europe, human dirofilariasis is a very rare zoonotic disease even in endemic areas such as Italy, Spain and the Mediterranean.
  
  
  METHODS
  The authors reported the case of a 43-year-old male with a subcutaneous nodule caused by Dirofilaria repens. The patient who lives in Budva, Montenegro, had a nodule in the right-hand side of the anterior abdominal walljust below the sternum with maximum diameter of 3 cm. His health condition was good and all laboratory analyses were normal. The lesion was surgically removed and the histopathological examination confirmed the parasitic infection by Dirofilaria repens. After surgical excision, the patient was treated with dual antimicrobial therapy (100 mg doxycycline per os twice a day for 28 days and 200 mg albendazole per os twice a day for 10 days).
  
  
  CONCLUSIONS
  It is very difficult to make the diagnosis of a subcutaneous nodule. The difficulties arise in the differential diagnosis because subcutaneous nodules are suspected to be malignant neoplasm or other pathologies such as tuberculosis, fungal infections, sebaceous cysts, hamartomas, abscesses, and so on. Although human dirofilariasis is a rare disease, the number of reported cases has recently been increasing worldwide.
authors.forename: Aleksandra P
authors.initials: AP
authors.lastname: Radovanović Spurnić
authors.forename: Goran
authors.initials: G
authors.lastname: Stevanović
authors.forename: Zorica
authors.initials: Z
authors.lastname: Dakić
authors.forename: Irena
authors.initials: I
authors.lastname: Ofori Belić
authors.forename: Igor
authors.initials: I
authors.lastname: Spurnić
authors.forename: Mijomir
authors.initials: M
authors.lastname: Pelemiš
mesh_terms: D034861:Abdominal Wall; D000328:Adult; D015766:Albendazole / Q000627:therapeutic use; D000871:Anthelmintics / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004184:Dirofilariasis / Q000175:diagnosis* / Q000628:therapy; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D008297:Male; D054548:Montenegro; D012876:Skin Diseases, Parasitic / Q000175:diagnosis* / Q000628:therapy
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D015766:Albendazole; D004318:Doxycycline