title: Helicobacter pylori infection in children with portal hypertensive gastropathy.
abstract: BACKGROUND
  Data about the association of Helicobacter pylori (H. pylori) and portal hypertensive gastropathy (PHG) are scarce in children. The present study aimed to fill the knowledge gap in this area.
  
  
  METHODS
  The prevalence of H. pylori infection was studied in a group of infants and children with PHG using rapid urease test and histological demonstration of H. pylori in gastric mucosal biopsy obtained by upper gastrointestinal endoscopy. The results were compared to a control group who underwent endoscopy for other indications mainly hematemesis and/or dyspepsia.
  
  
  RESULTS
  H. pylori was equally prevalent in both groups (~60%). Children with PHG were significantly stunted in height, had significantly lower hemoglobin, platelets and serum iron. Severe PHG was associated with higher grade of esophageal varices. Within the group with PHG, H. pylori infection was associated with lower hemoglobin, serum iron and serum ferritin. Moderate to severe PHG was more associated with H. pylori infection.
  
  
  CONCLUSIONS
  H. pylori infection was not more commonly associated with PHG, however, it might contribute to the severity of PHG. The synergistic effect of PHG and H. pylori infection might contribute to the retarded growth and iron deficiency status noted in this group.
authors.affiliation: Department of Pediatrics, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Ayman E
authors.initials: AE
authors.lastname: Eskander
authors.affiliation: Department of Pathology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Bahaa I
authors.initials: BI
authors.lastname: Mounir
authors.affiliation: Department of Pediatrics, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Carolyne
authors.initials: C
authors.lastname: Morcos Ghobrial
authors.affiliation: Department of Pediatrics, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt - hanaakaraksy@kasralainy.edu.eg.
authors.forename: Hanaa M
authors.initials: HM
authors.lastname: El-Karaksy
mesh_terms: D001706:Biopsy / Q000379:methods; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D004932:Esophageal and Gastric Varices / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006130:Growth Disorders / Q000453:epidemiology / Q000209:etiology; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications* / Q000503:physiopathology; D000090463:Iron Deficiencies; D008297:Male; D015995:Prevalence; D012720:Severity of Illness Index; D013272:Stomach Diseases / Q000150:complications*