title: Acutely deteriorated extravascular volume overload during peripheral blood stem cell mobilization in POEMS syndrome: A case series with cytokine analysis.
abstract: We describe two cases of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndrome patients with deteriorated extravascular volume overload without increased levels of vascular endothelial growth factor after the administration of cyclophosphamide + granulocyte colony-stimulating factor for stem cell mobilization. We then measured the serum levels of 27 cytokines from these cases using a multiplex suspension array system. The analysis revealed the changes of cytokine profiles before cyclophosphamide + granulocyte colony-stimulating factor and after the development of capillary leak symptoms in both cases. This may improve our current level of understanding of the pathogenesis of POEMS syndrome not driven by vascular endothelial growth factor.
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Muto
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Ohwada
authors.affiliation: Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Setsu
authors.initials: S
authors.lastname: Sawai
authors.affiliation: Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Beppu
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Shokichi
authors.initials: S
authors.lastname: Tsukamoto
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan; Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Mimura
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Sakaida
authors.affiliation: School of Life and Environmental Science, Azabu University, Kanagawa, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sogawa
authors.affiliation: Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Sonoko
authors.initials: S
authors.lastname: Misawa
authors.affiliation: Department of Blood Transfusion, Toho University Medical Center Sakura Hospital, Chiba, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Shimizu
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan; Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Iseki
authors.affiliation: Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Nomura
authors.affiliation: Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan. Electronic address: chiaki-nakaseko@faculty.chiba-u.jp.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakaseko
mesh_terms: D064592:Autografts; D016207:Cytokines / Q000097:blood*; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation; D000072916:Peripheral Blood Stem Cells; D014057:Tomography, X-Ray Computed
chemical_list: D016207:Cytokines
keywords: Cytokine profile; Extravascular volume overload; POEMS syndrome; Peripheral blood stem cell mobilization; Vascular endothelial growth factor