title: The European project NanoAthero to fight cardiovascular diseases using nanotechnologies.
abstract: Cardiovascular diseases are the main causes of death in the world. Nanosystems with contrast agents or drugs appear as promising tools for early detection and treatments. NanoAthero, a large-scale 5-year project funded by the European Union FP7 gathers 16 partners from ten different countries to demonstrate the benefit of the use of nanoparticle technologies. Through the design and characterization of nanosystems, preclinical and clinical validations, toxicology, industrial development and production in good manufacturing practice forms, several studies are underway for plaque and stroke both for imaging and treatment. A clinical study was already completed using a good manufacturing practice liposomal formulation in patients with carotid atheroma. NanoAthero is a unique opportunity to open new strategies for the management of cardiovascular diseases.
authors.affiliation: Inserm, U1148, Department of Cardiovascular Bio-Engineering, X Bichat Hospital, University Paris Diderot, 46 rue H Huchard, 75018 Paris, France.|Institut Galilée, University Paris 13, Sorbonne Paris Cité, 93430 Villetaneuse, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Chauvierre
authors.affiliation: Inserm, U1148, Department of Cardiovascular Bio-Engineering, X Bichat Hospital, University Paris Diderot, 46 rue H Huchard, 75018 Paris, France.|Institut Galilée, University Paris 13, Sorbonne Paris Cité, 93430 Villetaneuse, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Letourneur
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000473:pathology; D016503:Drug Delivery Systems; D005060:Europe; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D008081:Liposomes
keywords: cardiovascular diseases; clinical studies; drug loading; molecular imaging; nanocarriers; nanomedicine; preclinical studies; therapy