title: A Case of a Bilateral Cicatricial Upper Eyelid Entropion After Hematopoietic Stem Cell Transplantation in Mucopolysaccharidosis Type I.
abstract: Minor eyelid abnormalities are commonly encountered in mucopolysaccharidosis, but only rarely leading to a clinically relevant situation. The authors report a clinical case of severe bilateral cicatricial entropion of the upper eyelids, leading to recurrent conjunctival infections, corneal erosion, persistent epiphora, and a major decline in life quality in a 7-year-old boy with mucopolysaccharidosis type I who underwent hematopoietic stem cell transplantation at 1.6 years old. A bilateral anterior lamellar repositioning including eyelid split and cryoepilation was performed to correct bilateral upper eyelid entropium and trichiasis. Three months after the surgical intervention, the patient showed a persistent regular eyelid position with only mild recurrent right-sided lateral upper eyelid entropion. A significant reduction in conjunctival infections and epiphora with complete discontinuation of topical therapy was achieved. Although mucopolysaccaridosis is associated with eyelid abnormalities, the authors conclude that the described case is most likely due to chronic graft versus host disease.
authors.affiliation: *Department of Ophthalmology, and †University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Simon
authors.initials: S
authors.lastname: Dulz
authors.forename: Lars
authors.initials: L
authors.lastname: Wagenfeld
authors.forename: Gisbert
authors.initials: G
authors.lastname: Richard
authors.forename: Johanna
authors.initials: J
authors.lastname: Schrum
authors.forename: Nicole
authors.initials: N
authors.lastname: Muschol
authors.forename: Matthias
authors.initials: M
authors.lastname: Keserü
mesh_terms: D019882:Blepharoplasty / Q000379:methods; D002648:Child; D002921:Cicatrix / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D004774:Entropion / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D005143:Eyelids / Q000473:pathology* / Q000601:surgery; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008059:Mucopolysaccharidosis I / Q000601:surgery*