title: Pathogenesis and Therapeutic Strategies in Alzheimer's Disease: From Brain to Periphery.
abstract: Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative disorder. At present, there are no effective disease-modifying therapies, and the cause of the disease remains unclear. Previously, almost all researchers focus on the brain for exploring the pathogenesis and therapeutic strategies in AD. A recent study by Xiang et al. (Acta Neuropathol 130:487-499, 2015) reported the significance of the physiological capacity of peripheral tissues and organs in clearing brain-derived amyloid-beta (Aβ), which opens a novel avenue to understand the AD pathogenesis and develop therapies for AD.
authors.affiliation: Department of Neurology, Memory and Aging Center, University of California, San Francisco, 675 Nelson Rising Lane, Suite 190, Box 1207, San Francisco, CA, 94158, USA. jintai.yu@ucsf.edu.
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.affiliation: Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
authors.forename: Can
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000378:metabolism* / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000097:blood / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans
chemical_list: D016229:Amyloid beta-Peptides
keywords: Alzheimer’s disease; Amyloid-beta; Pathogenesis; Periphery; Therapy