title: Synthesis of Functionalized 1H-Isochromene Derivatives via a Au-Catalyzed Domino Cycloisomerization/Reduction Approach.
abstract: A Au-catalyzed versatile and efficient access to 1H-isochromenes is reported. The efficiency of the [AuCl2(Pic)] complex (1-5 mol %) was demonstrated and allowed a domino cycloisomerization/reduction reaction process starting from a wide range of functionalized ortho-alkynylbenzaldehydes and one example of ortho-alkynylpyridinylaldehyde. The smooth reaction conditions were amenable to aryl- and alkyl-substituted alkynyl derivatives, as well as functionalized halogen and ether moieties, leading to a chemo- and regioselective 6-endo-cyclization with good to excellent yields.
authors.affiliation: Chimie ParisTech, PSL Research University, CNRS, Institut de Recherche de Chimie Paris (IRCP) , F-75005 Paris, France.
authors.forename: Eder
authors.initials: E
authors.lastname: Tomás-Mendivil
authors.affiliation: Institut de Recherches Servier , 125 Chemin de Ronde, 78290 Croissy-Seine, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Starck
authors.affiliation: Institut de Recherches Servier , 125 Chemin de Ronde, 78290 Croissy-Seine, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Ortuno
authors.affiliation: Chimie ParisTech, PSL Research University, CNRS, Institut de Recherche de Chimie Paris (IRCP) , F-75005 Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Michelet