title: A pilot study of low-moderate drinking water arsenic contamination and chronic diseases among reproductive age women in Timiş County, Romania.
abstract: We conducted a pilot study of associations between drinking water contaminated by inorganic arsenic (iAs), mostly <10 μg/L, and self-reported chronic diseases in 297 pregnant women. Adjusted for confounding variables, we identified a positive association between iAs and heart disease (OR = 1.63, 95%CI 0.81-3.04, p = 0.094), which was stronger for women living at their current residence ≥ 10 years (OR = 2.47, 95%CI 0.87-10.43, p = 0.058). Confounder-adjusted associations were also suggested for iAs with kidney disease (OR = 1.32, 95%CI 0.77-2.21, p = 0.265) and with high blood pressure (OR = 1.36, 95%CI 0.68-2.39, p = 0.300). A post hoc power analysis indicated the need for a larger study with more statistical power.
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA.
authors.forename: Celeste D
authors.initials: CD
authors.lastname: Butts
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA. Electronic address: mbloom@albany.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Bloom
authors.affiliation: Environmental Health Center, Cluj-Napoca, Romania.
authors.forename: Iulia A
authors.initials: IA
authors.lastname: Neamtiu
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA.
authors.forename: Simona
authors.initials: S
authors.lastname: Surdu
authors.affiliation: Environmental Health Center, Cluj-Napoca, Romania.
authors.forename: Cristian
authors.initials: C
authors.lastname: Pop
authors.affiliation: University of Medicine and Pharmacy "Victor Babes", Timişoara, Romania; Gynecology Department of the Emergency County Hospital, Timişoara, Romania.
authors.forename: Doru
authors.initials: D
authors.lastname: Anastasiu
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA.
authors.forename: Edward F
authors.initials: EF
authors.lastname: Fitzgerald
authors.affiliation: Environmental Health Center, Cluj-Napoca, Romania; University of Medicine and Pharmacy "Iuliu Haţieganu", Cluj-Napoca, Romania.
authors.forename: Eugen S
authors.initials: ES
authors.lastname: Gurzau
mesh_terms: D000328:Adult; D001151:Arsenic / Q000633:toxicity*; D002908:Chronic Disease / Q000453:epidemiology*; D060766:Drinking Water / Q000032:analysis*; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011247:Pregnancy; D012383:Romania; D055815:Young Adult
chemical_list: D060766:Drinking Water; D001151:Arsenic
keywords: Arsenic; Blood pressure; Drinking water; Heart disease; Kidney disease; Thyroid disorder