title: Age and education adjusted normative data and discriminative validity for Rey's Auditory Verbal Learning Test in the elderly Greek population.
abstract: Rey's Auditory Verbal Learning Test (RAVLT) is a widely used neuropsychological test to assess episodic memory. In the present study we sought to establish normative and discriminative validity data for the RAVLT in the elderly population using previously adapted learning lists for the Greek adult population. We administered the test to 258 cognitively healthy elderly participants, aged 60-89 years, and two patient groups (192 with amnestic mild cognitive impairment, aMCI, and 65 with Alzheimer's disease, AD). From the statistical analyses, we found that age and education contributed significantly to most trials of the RAVLT, whereas the influence of gender was not significant. Younger elderly participants with higher education outperformed the older elderly with lower education levels. Moreover, both clinical groups performed significantly worse on most RAVLT trials and composite measures than matched cognitively healthy controls. Furthermore, the AD group performed more poorly than the aMCI group on most RAVLT variables. Receiver operating characteristic (ROC) analysis was used to examine the utility of the RAVLT trials to discriminate cognitively healthy controls from aMCI and AD patients. Area under the curve (AUC), an index of effect size, showed that most of the RAVLT measures (individual and composite) included in this study adequately differentiated between the performance of healthy elders and aMCI/AD patients. We also provide cutoff scores in discriminating cognitively healthy controls from aMCI and AD patients, based on the sensitivity and specificity of the prescribed scores. Moreover, we present age- and education-specific normative data for individual and composite scores for the Greek adapted RAVLT in elderly subjects aged between 60 and 89 years for use in clinical and research settings.
authors.affiliation: a Neuropsychology Section, Department of Neurology , University of Patras Medical School , Patras , Greece.
authors.forename: Lambros
authors.initials: L
authors.lastname: Messinis
authors.affiliation: b Higher Educational Institute of Epirus, Ioannina , Department of Speech and Language Therapy , Ioannina , Greece.
authors.forename: Grigorios
authors.initials: G
authors.lastname: Nasios
authors.affiliation: c Alzheimer Center of the Greek Psychogeriatric Association "Nestor," Athens , Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Mougias
authors.affiliation: d Department of Psychiatry, Eginition Hospial , School of Medicine, University of Athens , Athens , Greece.
authors.forename: Antonis
authors.initials: A
authors.lastname: Politis
authors.affiliation: e Department of Radiology , University of Patras Medical School , Patras , Greece.
authors.forename: Petros
authors.initials: P
authors.lastname: Zampakis
authors.affiliation: a Neuropsychology Section, Department of Neurology , University of Patras Medical School , Patras , Greece.
authors.forename: Eirini
authors.initials: E
authors.lastname: Tsiamaki
authors.affiliation: f Department of Mechanical Engineering & Aeronautics , University of Patras (statistics) , Patras , Greece.
authors.forename: Sonia
authors.initials: S
authors.lastname: Malefaki
authors.affiliation: g Department of Psychiatry , University of Patras Medical School , Patras , Greece.
authors.forename: Phillipos
authors.initials: P
authors.lastname: Gourzis
authors.affiliation: a Neuropsychology Section, Department of Neurology , University of Patras Medical School , Patras , Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Papathanasopoulos
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004522:Educational Status; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D012016:Reference Values; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric; D014706:Verbal Learning / Q000502:physiology*
keywords: Rey’s auditory verbal learning test; alzheimer’s disease.; composite measures; discriminant validity; episodic memory; greek; mild cognitive impairment; normative data elderly