title: Alteration of Regional Homogeneity within the Sensorimotor Network after Spinal Cord Decompression in Cervical Spondylotic Myelopathy: A Resting-State fMRI Study.
abstract: There is a lack of longitudinal research to evaluate the function of neurons' adaptive changes within the sensorimotor network (SMN) following recovery after cervical cord decompression. Regional homogeneity (ReHo) may provide information that is critical to fully understand CSM-related functional neural synchrony alterations. The purpose of this study was to assess the ReHo alterations of resting state-functional MRI (rs-fMRI) within pre- and postdecompression CSM and healthy controls (HC) and its correlations with clinical indices. Predecompression CSM demonstrated a significantly lower ReHo in the left primary sensory cortex and primary motor cortex (PostG/PreG) but enhanced ReHo in the right superior parietal lobule (SPL) compared with HC. In comparison with predecompression CSM, the postdecompression CSM showed increased ReHo in the left PostG/PreG but significantly lower ReHo in the right SPL compared with HC patients. Abnormal ReHo regions in pre- or postdecompression CSM showed no significant correlation with the Japanese Orthopaedic Association (JOA) scores, Neck Disability Index (NDI) scores, and disease duration (P > 0.05). This result demonstrated disrupted regional homogeneity within SMN in CSM. This adaptive change in the brain may favor the preservation of sensorimotor networks before and after cervical cord decompression and clinical symptoms independent of ReHo within SMN.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Yong Wai Street, No. 17, Nanchang, Jiangxi 330006, China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Yong Wai Street, No. 17, Nanchang, Jiangxi 330006, China.
authors.forename: Fuqing
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Yong Wai Street, No. 17, Nanchang, Jiangxi 330006, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Orthopaedic Surgery, The First Affiliated Hospital of Nanchang University, Yong Wai Street, No. 17, Nanchang, Jiangxi 330006, China.
authors.forename: Zhili
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Yong Wai Street, No. 17, Nanchang, Jiangxi 330006, China.
authors.forename: Xianjun
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Yong Wai Street, No. 17, Nanchang, Jiangxi 330006, China.
authors.forename: Honghan
authors.initials: H
authors.lastname: Gong
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Yong Wai Street, No. 17, Nanchang, Jiangxi 330006, China.
authors.forename: Laichang
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D011859:Radiography; D066191:Sensorimotor Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D013116:Spinal Cord / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D055009:Spondylosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery