title: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) and multiple pulmonary epithelioid hemangioendothelioma (PEH): a case report.
abstract: We report a case of a 76-year-old female with multiple lung nodules (Fig. 1 Rx). Pathologic evaluation of the lower left video-assisted thoracoscopic surgery (VATS) lobectomy VATS-lobectomy showed four nodules that were described as pulmonary epithelioid hemangio-endothelioma (PEH); the immunohistochemical stains showed that the neoplastic cells expressed CD31, a variable expression for factor VIII and a low expression of CD34. In the remaining parenchyma of the lobe, multiple nests of neuroendocrine cells were observed with immunohistochemical confirmation, and the diagnosis was diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). To our knowledge, the association between PEH and DIPNECH has never been described in the literature.
authors.forename: F
authors.initials: F
authors.lastname: Erdini
authors.forename: A Ambrosini
authors.initials: AA
authors.lastname: Spaltro
authors.forename: A
authors.initials: A
authors.lastname: Ruiu
authors.forename: M
authors.initials: M
authors.lastname: Pittertschatscher
authors.forename: G
authors.initials: G
authors.lastname: Resch
authors.forename: B
authors.initials: B
authors.lastname: Feil
authors.forename: R
authors.initials: R
authors.lastname: Carella
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D055613:Multiple Pulmonary Nodules / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D055099:Neuroendocrine Cells / Q000737:chemistry / Q000473:pathology*; D011013:Pneumonectomy / Q000379:methods; D011230:Precancerous Conditions / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor