title: Controversies in the Management of Severe ARDS: Optimal Ventilator Management and Use of Rescue Therapies.
abstract: Groundbreaking research into the pathophysiology of the adult acute respiratory distress syndrome (ARDS) and the prevention of ventilator-induced lung injury has led to dramatic improvements in survival. Investigations over the last two decades have revolved around the development of rescue therapies that can be used for patients with severe ARDS and refractory hypoxemia. To date, the techniques of using high levels of positive end-expiratory pressure (PEEP), prompt institution of neuromuscular blockade, and early prolonged prone positioning have been shown to reduce mortality in patients with severe ARDS. PEEP titration using transpulmonary pressure estimations assisted by esophageal manometry has been shown to result in a substantial improvement in oxygenation. Extracorporeal membrane oxygenation (ECMO) has been used increasingly since the mid-2000s in part due to the H1N1 epidemic. A major randomized controlled trial conducted during this period showed a significant mortality benefit for patients with severe ARDS who were referred to a center with ECMO capabilities. The routine use of inhaled nitric oxide for patients with severe ARDS has not been shown to lead to more than a transient and limited improvement in oxygenation, which may hinder its use as a sole rescue therapy. Finally, recent studies have found that the routine use of high-frequency oscillatory ventilation in severe ARDS does not result in decreased mortality, although the technique has not been specifically investigated as rescue therapy for severe refractory hypoxemia.
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
authors.forename: Brian
authors.initials: B
authors.lastname: O'Gara
authors.affiliation: Interdepartmental Division of Critical Care Medicine, Institute of Health Policy, Management and Evaluation University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada.
authors.forename: Eddy
authors.initials: E
authors.lastname: Fan
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Talmor
mesh_terms: D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D006612:High-Frequency Ventilation / Q000009:adverse effects*; D006801:Humans; D000860:Hypoxia / Q000628:therapy; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics; D007251:Influenza, Human / Q000453:epidemiology; D009569:Nitric Oxide / Q000627:therapeutic use*; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D016684:Prone Position; D016032:Randomized Controlled Trials as Topic; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D055397:Ventilator-Induced Lung Injury / Q000517:prevention & control*
chemical_list: D009569:Nitric Oxide