title: Automatic segmentation of the optic nerve head for deformation measurements in video rate optical coherence tomography.
abstract: Optical coherence tomography (OCT) imaging has become a standard diagnostic tool in ophthalmology, providing essential information associated with various eye diseases. In order to investigate the dynamics of the ocular fundus, we present a simple and accurate automated algorithm to segment the inner limiting membrane in video-rate optic nerve head spectral domain (SD) OCT images. The method is based on morphological operations including a two-step contrast enhancement technique, proving to be very robust when dealing with low signal-to-noise ratio images and pathological eyes. An analysis algorithm was also developed to measure neuroretinal tissue deformation from the segmented retinal profiles. The performance of the algorithm is demonstrated, and deformation results are presented for healthy and glaucomatous eyes.
authors.affiliation: Institut National de la Recherche Scientifique Centre Energie, Materiaux et Telecommunications, 1650 Boulevard Lionel-Boulet, Varennes, Québec J3X 1S2, CanadabMaisonneuve-Rosemont Hospital, Research Center, 5415 L'Assomption, Montreal, QC H1T 2M4, Canada.
authors.forename: Maribel
authors.initials: M
authors.lastname: Hidalgo-Aguirre
authors.affiliation: Maisonneuve-Rosemont Hospital, Research Center, 5415 L'Assomption, Montreal, QC H1T 2M4, Canada.
authors.forename: Julian
authors.initials: J
authors.lastname: Gitelman
authors.affiliation: Maisonneuve-Rosemont Hospital, Research Center, 5415 L'Assomption, Montreal, QC H1T 2M4, CanadacUniversite de Montreal, Ophthalmology Department, Faculty of Medicine, 2900 Boulevard Edouard-Montpetit, Montreal, QC H3T 1J4, Canada.
authors.forename: Mark Richard
authors.initials: MR
authors.lastname: Lesk
authors.affiliation: Maisonneuve-Rosemont Hospital, Research Center, 5415 L'Assomption, Montreal, QC H1T 2M4, CanadacUniversite de Montreal, Ophthalmology Department, Faculty of Medicine, 2900 Boulevard Edouard-Montpetit, Montreal, QC H3T 1J4, Canada.
authors.forename: Santiago
authors.initials: S
authors.lastname: Costantino
mesh_terms: D000465:Algorithms; D055119:Elastic Modulus; D005901:Glaucoma / Q000473:pathology* / Q000503:physiopathology; D006244:Hardness; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D009898:Optic Disk / Q000473:pathology* / Q000503:physiopathology; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D042262:Retinoscopy / Q000379:methods*; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D041623:Tomography, Optical Coherence / Q000379:methods*; D014741:Video Recording / Q000379:methods*