title: <mds_ies_db>: a database of ciliate genome rearrangements.
abstract: Ciliated protists exhibit nuclear dimorphism through the presence of somatic macronuclei (MAC) and germline micronuclei (MIC). In some ciliates, DNA from precursor segments in the MIC genome rearranges to form transcriptionally active genes in the mature MAC genome, making these ciliates model organisms to study the process of somatic genome rearrangement. Similar broad scale, somatic rearrangement events occur in many eukaryotic cells and tumors. The <mds_ies_db> (http://oxytricha.princeton.edu/mds_ies_db) is a database of genome recombination and rearrangement annotations, and it provides tools for visualization and comparative analysis of precursor and product genomes. The database currently contains annotations for two completely sequenced ciliate genomes: Oxytricha trifallax and Tetrahymena thermophila.
authors.affiliation: Department of Ecology and Evolutionary Biology, Princeton University, NJ 08544, USA Department of Mathematics & Statistics, University of South Florida, FL 33620, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Burns
authors.affiliation: Department of Mathematics & Statistics, University of South Florida, FL 33620, USA.
authors.forename: Denys
authors.initials: D
authors.lastname: Kukushkin
authors.affiliation: Department of Ecology and Evolutionary Biology, Princeton University, NJ 08544, USA.
authors.forename: Kelsi
authors.initials: K
authors.lastname: Lindblad
authors.affiliation: Department of Ecology and Evolutionary Biology, Princeton University, NJ 08544, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Mathematics & Statistics, University of South Florida, FL 33620, USA.
authors.forename: Nataša
authors.initials: N
authors.lastname: Jonoska
authors.affiliation: Department of Ecology and Evolutionary Biology, Princeton University, NJ 08544, USA lfl@princeton.edu.
authors.forename: Laura F
authors.initials: LF
authors.lastname: Landweber
mesh_terms: D030561:Databases, Nucleic Acid; D015321:Gene Rearrangement; D016678:Genome; D058977:Molecular Sequence Annotation; D016813:Oxytricha / Q000235:genetics*; D011995:Recombination, Genetic; D016808:Tetrahymena thermophila / Q000235:genetics*