title: Clinical Applications of Myocardial Innervation Imaging.
abstract: Cardiac autonomic innervation plays an important role in regulating function. Adrenergic innervation imaging is possible with the norepinephrine analogue radiotracer iodine 123 meta-iodobenzylguanidine ((123)I-mIBG) and positron emitting tracers such carbon-11 hydroxyephedrine. (123)I-mIBG uptake is assessed globally via the heart to mediastinum ratio on planar images and regionally with tomographic imaging and has utility in various cardiac diseases. There is promise for guiding expensive invasive therapies such as implantable defibrillators, ventricular assist devices, and transplant. There are reports of utility in primary arrhythmic conditions, ischemic heart disease, and diabetes and after cardiac damaging chemotherapy.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, 111 East-210th Street, Bronx, NY 10467-2490, USA. Electronic address: mtravin@montefiore.org.
authors.forename: Mark I
authors.initials: MI
authors.lastname: Travin
mesh_terms: D019797:3-Iodobenzylguanidine; D057791:Cardiac Imaging Techniques; D006321:Heart / Q000294:innervation*; D006333:Heart Failure / Q000175:diagnosis*; D006801:Humans; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine
keywords: Adrenergic innervation; Cardiac arrhythmias; Heart failure; Molecular imaging; mIBG