title: Changes in health-related quality of life (HRQoL) after discharge from intensive care unit: a protocol for a systematic review.
abstract: BACKGROUND
  Treatment on an intensive care unit (ICU) imposes a high treatment burden on patients, as well as an economic burden for the healthcare provider. Many studies have recorded health-related quality of life (HRQoL) in patients after treatment on an ICU. We propose a systematic review of these studies.
  
  
  METHODS
  We will search the National Library of Medicine's PubMed electronic database (PubMed), the Cochrane database, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science and Open Grey to identify papers reporting quality of life after discharge from ICU. We will include papers including validated quality of life measures. We will examine three categories: populations of patients treated on general ICUs, patients with severe infections and patients with respiratory dysfunction. We will extract HRQoL data. We will assess papers for risk of bias using the QUADAS-2 tool. The strength of our conclusions will depend on the quality and number of papers showing uniform results.
  
  
  BACKGROUND
  This review will use published literature and contains no primary data; so we do not need ethical approval. We will submit the outcome of the systematic review to a peer-reviewed journal.
  
  
  BACKGROUND
  PROSPERO CRD42015024700.
authors.affiliation: Kadoorie Centre for Critical Care Research and Education, John Radcliffe Hospital, Oxford, UK.
authors.forename: Alice M J
authors.initials: AM
authors.lastname: Gerth
authors.affiliation: Kadoorie Centre for Critical Care and Trauma Research and Education, John Radcliffe Hospital, Oxford, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Watkinson
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
authors.forename: J Duncan
authors.initials: JD
authors.lastname: Young
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010351:Patient Discharge / Q000706:statistics & numerical data*; D011788:Quality of Life; D012107:Research Design; D000078202:Systematic Reviews as Topic; D055815:Young Adult
keywords: HRQoL; Health Related Quality of Life; INTENSIVE & CRITICAL CARE