title: Is in vivo amyloid distribution asymmetric in primary progressive aphasia?
abstract: We aimed to determine whether (18) F-florbetapir amyloid positron emission tomography imaging shows a clinically concordant, left-hemisphere-dominant pattern of deposition in primary progressive aphasia (PPA). Elevated cortical amyloid (Aβ(+) ) was found in 19 of 32 PPA patients. Hemispheric laterality of amyloid burden was compared between Aβ(+) PPA and an Aβ(+) amnestic dementia groups (n = 22). The parietal region showed significantly greater left lateralized amyloid uptake in the PPA group than the amnestic group (p < 0.007), consistent with the left lateralized pattern of neurodegeneration in PPA. These results suggest that the cortical distribution of amyloid may have a greater clinical concordance than previously reported.
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL.
authors.forename: Adam
authors.initials: A
authors.lastname: Martersteck
authors.affiliation: The University of Arizona College of Medicine, Tucson, AZ.
authors.forename: Christopher
authors.initials: C
authors.lastname: Murphy
authors.affiliation: NU Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL.
authors.forename: Alfred
authors.initials: A
authors.lastname: Rademaker
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL.
authors.forename: Christina
authors.initials: C
authors.lastname: Wieneke
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL.|NU Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL.
authors.forename: Sandra
authors.initials: S
authors.lastname: Weintraub
authors.affiliation: Banner Alzheimer's Institute, Phoenix, AZ.
authors.forename: Kewei
authors.initials: K
authors.lastname: Chen
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL.|NU Feinberg School of Medicine, Department of Neurology, Chicago, IL.
authors.forename: M-Marsel
authors.initials: MM
authors.lastname: Mesulam
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL.
authors.forename: Emily
authors.initials: E
authors.lastname: Rogalski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds / Q000493:pharmacokinetics; D018888:Aphasia, Primary Progressive / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D004292:Dominance, Cerebral; D005026:Ethylene Glycols / Q000493:pharmacokinetics; D006321:Heart; D006801:Humans; D008297:Male; D008875:Middle Aged; D057054:Molecular Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D005026:Ethylene Glycols; D019275:Radiopharmaceuticals; C545186:florbetapir