title: Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis.
abstract: Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented.
authors.affiliation: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Klopries
authors.affiliation: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
authors.forename: Kenny
authors.initials: K
authors.lastname: Bravo-Rodriguez
authors.affiliation: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany.
authors.forename: Kyra R M
authors.initials: KR
authors.lastname: Koopmans
authors.affiliation: Dr. Fooke-Achterrath Laboratorien GmbH, Habichtweg 16, 41468 Neuss, Germany.
authors.forename: Uschi
authors.initials: U
authors.lastname: Sundermann
authors.affiliation: Université de Caen Basse-Normandie, Centre d'Etudes et de Recherche sur le Médicament de Normandie, F-14032 Caen, France.
authors.forename: Samir
authors.initials: S
authors.lastname: Yahiaoui
authors.affiliation: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Arens
authors.affiliation: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany.
authors.forename: Susanna
authors.initials: S
authors.lastname: Kushnir
authors.affiliation: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
authors.forename: Elsa
authors.initials: E
authors.lastname: Sanchez-Garcia
authors.affiliation: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Schulz