title: Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population.
abstract: The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the study between 2012 and 2014. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype the rs35767 and rs972936 IGF-1 polymorphisms. By comparing the demographic characteristics between patients and controls, patients with osteoporosis were found to be more likely to have a habit of alcohol drinking (P = 0.023). Furthermore, the BMD levels of the L1-L4 vertebrae, femoral necks, total hips, and trochanters in patients with osteoporosis were significantly lower than those in controls. By conditional regression analysis, we found that the IGF-1 rs2288377 and rs972936 gene polymorphisms were not associated with the risk of osteoporosis (P < 0.05). However, the CT+TT genotype of rs35767 and the AG+GG genotype of rs972936 were significantly associated with lower BMD levels in the femoral neck. Overall, our study suggests that IGF-1 rs2288377 and rs972936 gene polymorphisms do not influence the risk osteoporosis.
authors.affiliation: Department of Orthopaedics, 3201 Affiliated Hospital, School of Medicine, Xiꞌan Jiaotong University, Hanzhong, China.
authors.forename: Y K
authors.initials: YK
authors.lastname: Wei
authors.affiliation: Hangzhong Vocational and Technical College, Hanzhong, China.
authors.forename: H L
authors.initials: HL
authors.lastname: Ma
authors.affiliation: Hangzhong Zhenba Orthopaedic Hospital, Hanzhong, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Guo
authors.affiliation: Department of Orthopaedics, 3201 Affiliated Hospital, School of Medicine, Xiꞌan Jiaotong University, Hanzhong, China.
authors.forename: B H
authors.initials: BH
authors.lastname: Yang
authors.affiliation: Hangzhong Zhenba Orthopaedic Hospital, Hanzhong, China.
authors.forename: W X
authors.initials: WX
authors.lastname: Pang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D015519:Bone Density / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D005272:Femur Neck; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000235:genetics
chemical_list: D007334:Insulin-Like Growth Factor I