title: Sensitivity analysis aimed at blood vessels detection using interstitial optical tomography during brain needle biopsy procedures.
abstract: A brain needle biopsy procedure is performed for suspected brain lesions in order to sample tissue that is subsequently analysed using standard histopathology techniques. A common complication resulting from this procedure is brain hemorrhaging from blood vessels clipped off during tissue extraction. Interstitial optical tomography (iOT) has recently been introduced by our group as a mean to assess the presence of blood vessels in the vicinity of the needle. The clinical need to improve safety requires the detection of blood vessels within 2 mm from the outer surface of the needle, since this distance is representative of the volume of tissue that is aspirated durirng tissue extraction. Here, a sensitivity analysis is presented to establish the intrinsic detection limits of iOT based on simulations and experiments using brain tissue phantoms. It is demonstrated that absorbers can be detected with diameters >300 μm located up to >2 mm from the biopsy needle core for bulk optical properties consistent with brain tissue.
authors.affiliation: Department of Engineering Physics, Polytechnique Montreal, 2900 blvd Edouard-Montpetit, Campus de l'Université de Montréal, Montreal, Que, H3T 1J4, Canada.
authors.forename: Julien
authors.initials: J
authors.lastname: Pichette
authors.affiliation: Department of Engineering Physics, Polytechnique Montreal, 2900 blvd Edouard-Montpetit, Campus de l'Université de Montréal, Montreal, Que, H3T 1J4, Canada.
authors.forename: Andréanne
authors.initials: A
authors.lastname: Goyette
authors.affiliation: Department of Engineering Physics, Polytechnique Montreal, 2900 blvd Edouard-Montpetit, Campus de l'Université de Montréal, Montreal, Que, H3T 1J4, Canada.
authors.forename: Fabien
authors.initials: F
authors.lastname: Picot
authors.affiliation: Department of Engineering Physics, Polytechnique Montreal, 2900 blvd Edouard-Montpetit, Campus de l'Université de Montréal, Montreal, Que, H3T 1J4, Canada.
authors.forename: Marie-Andrée
authors.initials: MA
authors.lastname: Tremblay
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal, rue Saint-Denis, Que, Canada.
authors.forename: Gilles
authors.initials: G
authors.lastname: Soulez
authors.affiliation: Division of Biophysics and Bioimaging, Ontario Cancer Institute, 610 University Avenue, Toronto, On, M5B 2K3, Canada.
authors.forename: Brian C
authors.initials: BC
authors.lastname: Wilson
authors.affiliation: Department of Engineering Physics, Polytechnique Montreal, 2900 blvd Edouard-Montpetit, Campus de l'Université de Montréal, Montreal, Que, H3T 1J4, Canada ; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, rue Saint-Denis, Que, Canada.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Leblond
keywords: (110.0113) Imaging through turbid media; (110.2350) Fiber optics imaging; (120.3890) Medical optics instrumentation; (170.3880) Medical and biological imaging