title: TCM, brain function and drug space.
abstract: Covering: up to 2015. Traditional Chinese medicine has played a significant role in the mainstream healthcare system in China for thousands of years. Here, we summarize 84 major compounds from 15 selected herbal medicines targeting neurodegenerative diseases. We present a perspective based on the analysis of physicochemical properties of these TCM compounds, and comparison with current drugs and candidates for the treatment of Parkinson's and Alzheimer's disease. The results demonstrate that traditional Chinese medicines contain compounds possessing physicochemical properties that have excellent overlap with developed western medicines.
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia. r.quinn@griffith.edu.au and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors.forename: Chunping
authors.initials: C
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China and Eskitis-SIMM Joint Laboratory for Drug Discovery, Australia.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia. r.quinn@griffith.edu.au and Eskitis-SIMM Joint Laboratory for Drug Discovery, Australia.
authors.forename: Yunjiang
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia. r.quinn@griffith.edu.au and Eskitis-SIMM Joint Laboratory for Drug Discovery, Australia.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D001921:Brain / Q000503:physiopathology*; D006801:Humans; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010300:Parkinson Disease / Q000188:drug therapy; D010946:Plants, Medicinal / Q000737:chemistry*