title: N-Nicotinoyl dopamine inhibits skin pigmentation by suppressing of melanosome transfer.
abstract: We investigated the inhibitory effects of a niacinamide derivative, N-Nicotinoyl dopamine (NND) on melanogenesis. NND inhibits melanosome transfer in a normal human melanocyte-keratinocyte co-culture system and through phagocytic ability without affecting viability of cells while it did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. In addition, safety of NND was verified through performing neural stem cell morphology assay. Our findings indicate that NND may potentially be used for cosmetic industry for improvement of skin whitening and therapies related with several skin disorders, and the effect of NND may be acquired via reduction of melanosome transfer.
authors.affiliation: Skin & Bio Research, Ellead Co., Ltd., Gyeonggi 463-824, Republic of Korea.
authors.forename: Bora
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Genetic Engineering, Graduate School of Biotechnology and Skin Biotechnology Center, Kyung Hee University, Gyeonggi 443-766, Republic of Korea.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Hwang
authors.affiliation: Department of Food Science and Technology, Jungwon University, Chungbuk 367-805, Republic of Korea. Electronic address: hyun1006@jwu.ac.kr.
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D018920:Coculture Techniques; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects; D008546:Melanoma, Experimental / Q000473:pathology; D020460:Melanosomes / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism; D058953:Neural Stem Cells / Q000187:drug effects; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D010586:Phagocytes / Q000166:cytology / Q000187:drug effects; D051381:Rats; D012880:Skin Pigmentation / Q000187:drug effects*
chemical_list: D009536:Niacinamide; D014442:Monophenol Monooxygenase; D004298:Dopamine; C000610699:N-nicotinoyl dopamine
keywords: Melanogenesis; Melanosome transfer; N-Nicotinoyl dopamine