title: Uterine artery embolization combined with curettage vs. methotrexate plus curettage for cesarean scar pregnancy.
abstract: To compare the efficacy and safety of uterine artery embolization (UAE) combined with curettage and methotrexate (MTX) plus curettage in the treatment of cesarean scar pregnancy (CSP).
  
  
  
  From January 2005 to December 2013, we treated 38 CSP patients with UAE combined with curettage, and another 26 patients with CSP were treated with methotrexate (MTX) plus curettage. The resulting data were analyzed statistically.
  
  
  
  The median volume of blood loss was 17.5 ml in the UAE combined with curettage (UAE-C) group vs. 335 ml in the MTX plus curettage (MTX-C) group (p < 0.001). The time from the procedure till β-human chorionic gonadotropin (β-hCG) concentration returned to normal was 25.13 ± 3.74 days in the UAE-C group vs. 56.15 ± 15.99 days in the MTX-C group (p < 0.001). The duration of hospitalization was 7.44 ± 1.92 vs. 19.38 ± 8.75 days, respectively (p < 0.001). The percentage of side effects in the UAE-C group was significantly lower than in the MTX-C group.
  
  
  
  UAE combined with curettage appears to be superior to MTX plus curettage for treatment of CSP with high serum β-hCG level, though prospective trials are needed.
authors.affiliation: Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250012, Shandong, People's Republic of China. 2583546770@qq.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250012, Shandong, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Interventional Radiology, Shandong Medical Imaging Research Institute, 324 Jingwu Road, Jinan, 250012, Shandong, People's Republic of China.
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Interventional Radiology, Shandong Medical Imaging Research Institute, 324 Jingwu Road, Jinan, 250012, Shandong, People's Republic of China.
authors.forename: Zengtao
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000009:adverse effects; D002921:Cicatrix / Q000209:etiology; D003475:Curettage / Q000379:methods*; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000628:therapy*; D012189:Retrospective Studies; D055357:Uterine Artery Embolization / Q000009:adverse effects / Q000379:methods*
chemical_list: D008727:Methotrexate
keywords: Cesarean scar pregnancy; Curettage; Methotrexate; Treatment; Uterine artery embolization