title: [Correlation Study on Pathological Characteristics of Target Organs and Excess Evil Syndrome in IgA Nephropathy].
abstract: OBJECTIVE
  To explore the correlation between pathological characteristics of target organs and excess evil syndrome in IgA nephropathy.
  
  
  METHODS
  Data were collected in multicenter cooperation. Totally 266 IgA nephropathy patients were typed into exogenous wind-heat affection syndrome (49 cases), lower energizer damp-heat syndrome (100 cases), damp-phlegm syndrome (43 cases), and blood stasis syndrome (74 cases). Meanwhile, percutaneous renal biopsy was performed in all patients for Hass classification, Oxford classification, Katafuchi integral, and Jiang's classification methods. The correlation between excess evil syndrome and pathological index was analyzed.
  
  
  RESULTS
  Four syndrome types were correlated with their Hass levels (r = 0. 341, P <0. 01). Affection of exogenous wind-heat syndrome was correlated with segmental proliferation of endothelial cells and damaged active lesions of segmental capillary loops. Lower-energizer damp-heat syndrome was associated with Hass III level, destroying active lesions of capillary loops, segmental proliferation of endothelial cells, glomerular segmental lesions, focal interstitial infiltration of inflammatory cells, focal interstitial fibrosis and tubular atrophy. Blood stasis syndrome was associated with Hass IV level, glomerular sclerosis, segmental glomerulosclerosis (S)/adhesion, mesangial hypercellularity (M), angiohyalinosis, multi-foci interstitial infiltration of inflammatory cells, multi-foci interstitial fibrosis and tubular atrophy. Phlegm-damp syndrome had higher proportions of Hass I and III levels, but with no association with other pathological parameters.
  
  
  CONCLUSIONS
  Excess evil syndrome was associated with partial pathological characteristics of IgA nephropathy. It could reflect pathological damage degree of target organs, activities, chronic lesions, and prognosis of IgA nephropathy to certain extent. Correlated pathological characteristics and its evolution could indicate excess evil syndrome types and their evolution rules.
authors.forename: Ting-xin
authors.initials: TX
authors.lastname: Wan
authors.forename: En-lai
authors.initials: EL
authors.lastname: Dai
authors.forename: Wen-ge
authors.initials: WG
authors.lastname: Wang
authors.forename: Tian-xi
authors.initials: TX
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Yin-xia
authors.initials: YX
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.forename: Zhu-hua
authors.initials: ZH
authors.lastname: Zhao
authors.forename: Bai-quan
authors.initials: BQ
authors.lastname: Yang
mesh_terms: D002196:Capillaries; D005355:Fibrosis; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental; D006801:Humans; D007678:Kidney Glomerulus; D008516:Medicine, Chinese Traditional; D011379:Prognosis; D013577:Syndrome