title: Neuroprotective effects of Tilia americana var. mexicana on damage induced by cerebral ischaemia in mice.
abstract: Tilia americana var. mexicana (T. americana) is a plant widely used in Mexico for its medicinal properties on the central nervous system. In the present study, we designed a protocol to investigate the neuroprotective effects of non-polar and polar extracts of T. americana on damage induced by cerebral ischaemia in mice. Vehicle or extracts were administered immediately after ischaemia. Functional neurological deficit, survival percentage and infarct area were determined in each experimental group. Results showed that groups treated with non-polar or polar extracts of T. americana had increased survival rate, improved neurological deficits and diminished the infarct area in relation to the ischaemic group. In conclusion, this study confirms the neuroprotective activity of T. americana, suggests a possible synergism between non-polar and polar constituents and supports its potential as a useful aid in the clinical management of stroke.
authors.affiliation: a Facultad de Medicina, Departamento de Farmacología , Universidad Nacional Autónoma de México , México D.F. , Mexico.
authors.forename: Guadalupe E
authors.initials: GE
authors.lastname: Angeles-López
authors.affiliation: b Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias , Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz" , México D.F. , Mexico.
authors.forename: Ma Eva
authors.initials: ME
authors.lastname: González-Trujano
authors.affiliation: a Facultad de Medicina, Departamento de Farmacología , Universidad Nacional Autónoma de México , México D.F. , Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Gómez
authors.affiliation: c Laboratorio de Patologia Vascular Cerebral , Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez" , México D.F. , Mexico.
authors.forename: Ma Elena
authors.initials: ME
authors.lastname: Chánez-Cárdenas
authors.affiliation: a Facultad de Medicina, Departamento de Farmacología , Universidad Nacional Autónoma de México , México D.F. , Mexico.
authors.forename: Rosa
authors.initials: R
authors.lastname: Ventura-Martinez
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D002544:Cerebral Infarction / Q000473:pathology / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006586:Hexanes; D051379:Mice; D009422:Nervous System Diseases / Q000517:prevention & control / Q000523:psychology; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D012997:Solvents; D016019:Survival Analysis; D032384:Tilia / Q000737:chemistry*; D014867:Water
chemical_list: D006586:Hexanes; D018696:Neuroprotective Agents; D010936:Plant Extracts; D012997:Solvents; D014867:Water
keywords: Tilia americana var. mexicana (T. americana); damage induced by ischaemia; infarct area; neurological deficit; neuroprotective activity