title: Altered sensitization patterns to sweet food stimuli in patients recovered from anorexia and bulimia nervosa.
abstract: Recent studies show that higher-order appetitive neural circuitry may contribute to restricted eating in anorexia nervosa (AN) and overeating in bulimia nervosa (BN). The purpose of this study was to determine whether sensitization effects might underlie pathologic eating behavior when a taste stimulus is administered repeatedly. Recovered AN (RAN, n=14) and BN (RBN, n=15) subjects were studied in order to avoid the confounding effects of altered nutritional state. Functional magnetic resonance imaging (fMRI) measured higher-order brain response to repeated tastes of sucrose (caloric) and sucralose (non-caloric). To test sensitization, the neuronal response to the first and second administration was compared. RAN patients demonstrated a decreased sensitization to sucrose in contrast to RBN patients who displayed the opposite pattern, increased sensitization to sucrose. However, the latter was not as pronounced as in healthy control women (n=13). While both eating disorder subgroups showed increased sensitization to sucralose, the healthy controls revealed decreased sensitization. These findings could reflect on a neuronal level the high caloric intake of RBN during binges and the low energy intake for RAN. RAN seem to distinguish between high energy and low energy sweet stimuli while RBN do not.
authors.affiliation: University of California at San Diego, Department of Psychiatry, La Jolla, CA 92093-0603, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Wagner
authors.affiliation: University of California at San Diego, Department of Psychiatry, La Jolla, CA 92093-0603, USA; Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA 92161, USA.
authors.forename: Alan N
authors.initials: AN
authors.lastname: Simmons
authors.affiliation: University of California at San Diego, Department of Psychiatry, La Jolla, CA 92093-0603, USA; University of Colorado Denver Health Sciences Center, Department of Internal Medicine, 12631 E. 17th Avenue, Aurora, CO 80045, USA.
authors.forename: Tyson A
authors.initials: TA
authors.lastname: Oberndorfer
authors.affiliation: University of Colorado Denver Health Sciences Center, Department of Psychiatry, The Children's Hospital, 13123 E. 16th Avenue, Aurora, CO 80045, USA.
authors.forename: Guido K W
authors.initials: GK
authors.lastname: Frank
authors.affiliation: University of California at Los Angeles, Department of Psychiatry, Los Angeles, CA 90024-1759, USA.
authors.forename: Danyale
authors.initials: D
authors.lastname: McCurdy-McKinnon
authors.affiliation: University of Rochester Medical Center, Departments of Psychiatry and Neurobiology and Anatomy, 601 Elmwood Avenue, Rochester, NY 14642-8409, USA.
authors.forename: Julie L
authors.initials: JL
authors.lastname: Fudge
authors.affiliation: University of California at San Francisco, Department of Psychiatry, Division of Child and Adolescent Psychiatry, San Francisco, CA 94143, USA.
authors.forename: Tony T
authors.initials: TT
authors.lastname: Yang
authors.affiliation: University of California at San Diego, Department of Psychiatry, La Jolla, CA 92093-0603, USA; Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA 92161, USA.
authors.forename: Martin P
authors.initials: MP
authors.lastname: Paulus
authors.affiliation: University of California at San Diego, Department of Psychiatry, La Jolla, CA 92093-0603, USA. Electronic address: wkaye@ucsd.ed.
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000523:psychology; D056912:Binge-Eating Disorder; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D052018:Bulimia Nervosa / Q000503:physiopathology* / Q000523:psychology; D016022:Case-Control Studies; D004435:Eating; D002149:Energy Intake; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013649:Taste / Q000502:physiology*
chemical_list: D013395:Sucrose; C026285:trichlorosucrose
keywords: Eating disorders; FMRI; Habituation; Sensitization; Taste