title: The Performance of the Nottingham Prognosis Index and the Adjuvant Online Decision Making Tool for Prognosis in Early-stage Breast Cancer Patients.
abstract: BACKGROUND
  Prognostic tools are widely used in the practice of Oncology and have been developed to help stratify patients into specific risk-related grouping. We sought to apply of two such tools used for patients with early-stage breast cancer and to correlate them with actual outcomes.
  
  
  METHODS
  A retrospective study was designed to include early-stage breast cancer cases seen from 1994 to 2014 at the Seyedoshohada Hospital in Isfahan, Iran. Information was derived from the patients' records, and indices were derived from prognostic tools. Information was analyzed using descriptive statistics and one sample t-test.
  
  
  RESULTS
  In 233 patients, the difference between the predicted overall survival (OS) by the Adjuvant Online (AO) prognosis tools (69.28) and the observed OS (71.2) was not statistically significant (P = 0.52), and the AO prognosis tools had predicted the patients' OS correctly. In the Nottingham prognosis index (NPI), this difference in all groups except the very poor prognosis group was not statistically significant.
  
  
  CONCLUSIONS
  Adjuvant Online prognosis tools were capable of predicting the 10-year OS rate although not in all of the subgroups. The NPI was capable of distinguishing good, moderate, and poor survival rates, but this ability was not visible in more specific groups with moderate and poor prognosis.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mehri
authors.initials: M
authors.lastname: Rejali
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Tazhibi
authors.affiliation: Department of Internal Medicine, Isfahan University of Medical Sciences, Breast Cancer Research Group, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Fariborz
authors.initials: F
authors.lastname: Mokarian
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Nazjamal
authors.initials: N
authors.lastname: Gharanjik
authors.affiliation: Department of Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Reyhane
authors.initials: R
authors.lastname: Mokarian
keywords: Early-stage breast cancer; Nottingham prognostic index; prognostic tools