title: Association between delivery of small-for-gestational-age neonate and long-term maternal chronic kidney disease.
abstract: OBJECTIVE
  To investigate whether delivery of a small for gestational age (SGA) neonate poses a risk for subsequent long-term maternal renal disease.
  
  
  METHODS
  A population-based study was conducted. Comparison was performed regarding the incidence of long-term renal morbidity in a cohort of women with and without a previous delivery of a SGA neonate. Deliveries occurred during a 25-year period, with a mean follow-up duration of 11.2 years. Renal morbidity included kidney transplantation, chronic renal failure and hypertensive renal disease. Cox proportional hazards model was used to estimate the adjusted hazards ratio (HR) for renal-related hospitalizations and mortality.
  
  
  RESULTS
  Out of 99 342 deliveries that met the inclusion criteria, 10 701 (10.7%) occurred in patients who had at least one previous delivery of a SGA neonate. During the follow-up period, patients with a delivery of an SGA neonate had higher rates of renal-related hospitalizations (0.2% versus 0.1%; OR = 1.6, 95% CI 1.01-2.5; p = 0.04). In a Cox proportional hazards model, adjusted for confounders, previous delivery of a SGA neonate was independently associated with subsequent maternal renal-related hospitalizations (adjusted HR, 1.7; 95% CI 1.1-2.8).
  
  
  CONCLUSIONS
  Delivery of a SGA neonate is an independent risk factor for long-term maternal renal disease.
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
authors.forename: Ofir
authors.initials: O
authors.lastname: Almasi
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
authors.forename: Gali
authors.initials: G
authors.lastname: Pariente
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
authors.forename: Roy
authors.initials: R
authors.lastname: Kessous
authors.affiliation: b Department of Epidemiology and Health Services Evaluation , Ben-Gurion University of the Negev , Beer-Sheva , Israel.
authors.forename: Ruslan
authors.initials: R
authors.lastname: Sergienko
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007236:Infant, Small for Gestational Age; D007557:Israel / Q000453:epidemiology; D011247:Pregnancy; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D012189:Retrospective Studies; D055815:Young Adult
keywords: Pregnancy complication; renal disease; small for gestational age