title: [A bilateral epithelial myoepithelial carcinoma of the parotid gland].
abstract: We report the case of a 52-year-old man, who was admitted in the department of otorhinolaryngology for a mass of the right parotid gland. The radiological and clinical hypothesis was a squamous cell carcinoma. Histopathological examination revealed a biphasic proliferation composed of epithelial cells arranged in a tubular pattern stained with cytokeratins 5-6 and 7 and EMA surrounded by clear myoepithelial cells stained with smooth muscle actin and p63. Ki-67 labeling index was low. The diagnosis of epithelial myoepithelial carcinoma was proposed. One year after, the patient noticed a centimetric mass of the left parotid gland. The radiological hypothesis was the presence of an intraparotidian lymph node. Histopathological examination showed a second epithelial myoepithelial carcinoma. This is an uncommon neoplasm comprising approximately 1% of all salivary gland tumours, affecting mainly the parotid gland. It is occurring preferably in patients older than 60years old. This is a low-grade malignant tumour with tendency to local recurrence and lymph node metastatic potential. We describe an exceptional bilateral epithelial myoepithelial carcinoma of the parotid gland.
authors.affiliation: Service de pathologie, centre hospitalier de Montbéliard, 12, rue Docteur-Flamand, 25200 Montbéliard, France. Electronic address: arnault.tauziedeespariat@gmail.com.
authors.forename: Arnault
authors.initials: A
authors.lastname: Tauziède-Espariat
authors.affiliation: Service de pathologie, centre hospitalier de Montbéliard, 12, rue Docteur-Flamand, 25200 Montbéliard, France.
authors.forename: Johnny
authors.initials: J
authors.lastname: Raffoul
authors.affiliation: Service de pathologie, centre hospitalier de Montbéliard, 12, rue Docteur-Flamand, 25200 Montbéliard, France.
authors.forename: Shan Rong
authors.initials: SR
authors.lastname: Sun
authors.affiliation: Service de pathologie, centre hospitalier de Montbéliard, 12, rue Docteur-Flamand, 25200 Montbéliard, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Monnin
authors.affiliation: Service de pathologie, centre hospitalier de Montbéliard, 12, rue Docteur-Flamand, 25200 Montbéliard, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Lassabe
authors.affiliation: Service de pathologie, CHU Lapeyronie, 191, avenue du Doyen-Giraud, 34295 Montpellier, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Costes
mesh_terms: D008949:Adenoma, Pleomorphic / Q000175:diagnosis; D014408:Biomarkers, Tumor; D002277:Carcinoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D053555:Keratin-5 / Q000032:analysis; D053553:Keratin-6 / Q000032:analysis; D053552:Keratin-7 / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D010307:Parotid Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D053555:Keratin-5; D053553:Keratin-6; D053552:Keratin-7; D018396:Mucin-1
keywords: Bilateral; Bilatérale; Carcinome épithélial myoépithélial; Epithelial myoepithelial carcinoma; Glande parotide; Parotid gland