title: [Effect of high-fat diet and food restriction on energy metabolism in obesity-prone and obesity-resistant rats].
abstract: OBJECTIVE
  To explore the effect of high-fat diet and food restriction on energy metabolism in obesity-prone (OP) and obesity-resistant (OR) rats.
  
  
  METHODS
  Sixty male Sprague-Dawley (SD) rats were divided into OP, OR and control groups according to their body weight gain after fed with high-fat diet for 3 wk. OP and OR groups were fed with high-fat diet in the following 12 wk to promote the development of obesity. Then one-half of the rats of each group began to food restriction and were allowed access to 50% of their individual baseline mean daily food intake each day, while the other half were maintained on ad libitum food for 2 wk. Basal metabolic rate (BMR), resting metabolic rate (RMR) of each group were measured by indirect calorimetry during the high-fat diet feeding and food restriction conditions. After the rats were sacrificed, body fat content was measured.
  
  
  RESULTS
  OR rats had significantly higher BMR and RMR than the other two groups during high-fat diet feeding condition. There was no significant difference between OP and control group. Food restriction led to a reduction in BMR and RMR in all groups. OR rats showed a significantly greater reduction. OP group showed a significant decrease in body fat weight and fat content during the food restriction period, while there was no significant differences in OR rats.
  
  
  CONCLUSIONS
  There are significant differences between OP and OR rats in BMR and RMR either in high-fat diet feeding condition or food restricted state. OR rat has the ability to sense and respond to energy imbalance more accurately than OP rat.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Liu
authors.forename: Junxia
authors.initials: J
authors.lastname: Wang
authors.forename: Long
authors.initials: L
authors.lastname: Zheng
authors.forename: Weiguang
authors.initials: W
authors.lastname: Lian
authors.forename: Shufeng
authors.initials: S
authors.lastname: Liu
mesh_terms: D000273:Adipose Tissue; D000818:Animals; D001823:Body Composition / Q000502:physiology; D001835:Body Weight; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000494:pharmacology*; D004435:Eating; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000502:physiology
chemical_list: D004041:Dietary Fats