title: Differential Expression of the Eicosanoid Pathway in Patients With Localized or Mucosal Cutaneous Leishmaniasis.
abstract: Unfettered inflammation is thought to play critical role in the development of different clinical forms of tegumentary leishmaniasis. Eicosanoids are potent mediators of inflammation and tightly associated with modulation of immune responses. In this cross-sectional exploratory study, we addressed whether targets from the eicosanoid biosynthetic pathway, assessed by multiplexed expression assays in lesion biopsy and plasma specimens, could highlight a distinct biosignature in patients with mucocutaneous leishmaniasis (MCL) or localized cutaneous leishmaniasis (LCL). Differences in immunopathogenesis between MCL and LCL may result from an imbalance between prostaglandins and leukotrienes, which may serve as targets for future host-directed therapies.
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ).
authors.forename: Jaqueline
authors.initials: J
authors.lastname: França-Costa
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ) Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Fundação José Silveira.
authors.forename: Bruno B
authors.initials: BB
authors.lastname: Andrade
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ).
authors.forename: Ricardo
authors.initials: R
authors.lastname: Khouri
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ) Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Van Weyenbergh
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ) Universidade Federal da Bahia, Salvador.
authors.forename: Hayna
authors.initials: H
authors.lastname: Malta-Santos
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ).
authors.forename: Claire
authors.initials: C
authors.lastname: da Silva Santos
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ) Universidade Federal da Bahia, Salvador Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia, São Paulo.
authors.forename: Cláudia I
authors.initials: CI
authors.lastname: Brodyskn
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ).
authors.forename: Jackson M
authors.initials: JM
authors.lastname: Costa
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ) Universidade Federal da Bahia, Salvador Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia, São Paulo.
authors.forename: Aldina
authors.initials: A
authors.lastname: Barral
authors.affiliation: Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
authors.forename: Patrícia T
authors.initials: PT
authors.lastname: Bozza
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ) Universidade Federal da Bahia, Salvador.
authors.forename: Viviane
authors.initials: V
authors.lastname: Boaventura
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ) Universidade Federal da Bahia, Salvador.
authors.forename: Valeria M
authors.initials: VM
authors.lastname: Borges
mesh_terms: D000328:Adult; D000368:Aged; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D015777:Eicosanoids / Q000097:blood / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000378:metabolism*; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D000981:Antiprotozoal Agents; D015777:Eicosanoids
keywords: biomarkers; eicosanoids; inflammation; leukotrienes; prostaglandin; tegumentary leishmaniasis