title: Nanoparticle dosage-a nontrivial task of utmost importance for quantitative nanosafety research.
abstract: For a detailed and correct understanding of effects of colloidal nanoparticles exposed to organisms, a correlation of such effects to the physicochemical properties of the nanoparticles is a necessity. Such correlation is complex by the fact that many physicochemical parameters such as size, shape, surface charge, and colloidal stability are interlinked, and nontrivial to experimentally determine. This review aims to give an overview regarding such correlations. Particular focus will be given on the role of determining nanoparticle concentrations, which is the basis for most quantitative toxicity evaluations. A comparison of mass versus particle number concentrations is given, and their respective differences are highlighted. WIREs Nanomed Nanobiotechnol 2016, 8:479-492. doi: 10.1002/wnan.1378 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Neus
authors.initials: N
authors.lastname: Feliu
authors.affiliation: Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pelaz
authors.affiliation: Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: CIC BiomaGUNE, San Sebastian, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Del Pino
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Andreas
authors.initials: A
authors.lastname: Nyström
authors.affiliation: Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.|CIC BiomaGUNE, San Sebastian, Spain.
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Parak
mesh_terms: D035843:Biomedical Research; D002460:Cell Line; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D018675:Toxicity Tests