title: Hydrogen sulfide prodrugs-a review.
abstract: Hydrogen sulfide (H2S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO). As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the development of H2S prodrugs for various reasons. In this review, we summarize different H2S prodrugs, their chemical properties, and some of their potential therapeutic applications.
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Xingyue
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Kaili
authors.initials: K
authors.lastname: Ji
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
keywords: Controllable H2S prodrugs; Gasotransmitters; H2S prodrugs; H2S-hybrid nonsteroidal anti-inflammatory drugs; Hydrogen sulfide (H2S); Hydrolysis-based H2S prodrugs