title: Addressing viral resistance through vaccines.
abstract: Antimicrobial resistance is a serious healthcare concern affecting millions of people around the world. Antiviral resistance has been viewed as a lesser threat than antibiotic resistance, but it is important to consider approaches to address this growing issue. While vaccination is a logical strategy, and has been shown to be successful many times over, next generation viral vaccines with a specific goal of curbing antiviral resistance will need to clear several hurdles including vaccine design, evaluation and implementation. This article suggests that a new model of vaccination may need to be considered: rather than focusing on public health, this model would primarily target sectors of the population who are at high risk for complications from certain infections.
authors.affiliation: Division of Microbiology & Infectious Diseases, National Institute of Allergy & Infectious Diseases (NIAID), NIH, 5601 Fishers Lane, Bethesda, MD 20852, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Laughlin
authors.affiliation: Division of Microbiology & Infectious Diseases, National Institute of Allergy & Infectious Diseases (NIAID), NIH, 5601 Fishers Lane, Bethesda, MD 20852, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Schleif
authors.affiliation: Division of Microbiology & Infectious Diseases, National Institute of Allergy & Infectious Diseases (NIAID), NIH, 5601 Fishers Lane, Bethesda, MD 20852, USA.
authors.forename: Carole A
authors.initials: CA
authors.lastname: Heilman
keywords: HIV; antimicrobial resistance; antiviral resistance; cytomegalovirus; hepatitis C; influenza; vaccine design; vaccine evaluation; vaccine implementation; vaccines