title: Fast segmentation of anterior segment optical coherence tomography images using graph cut.
abstract: BACKGROUND
  Optical coherence tomography (OCT) is a non-invasive imaging system that can be used to obtain images of the anterior segment. Automatic segmentation of these images will enable them to be used to construct patient specific biomechanical models of the human eye. These models could be used to help with treatment planning and diagnosis of patients.
  
  
  METHODS
  A novel graph cut technique using regional and shape terms was developed. It was evaluated by segmenting 39 OCT images of the anterior segment. The results of this were compared with manual segmentation and a previously reported level set segmentation technique. Three different comparison techniques were used: Dice's similarity coefficient (DSC), mean unsigned surface positioning error (MSPE), and 95% Hausdorff distance (HD). A paired t-test was used to compare the results of different segmentation techniques.
  
  
  RESULTS
  When comparison with manual segmentation was performed, a mean DSC value of 0.943 ± 0.020 was achieved, outperforming other previously published techniques. A substantial reduction in processing time was also achieved using this method.
  
  
  CONCLUSIONS
  We have developed a new segmentation technique that is both fast and accurate. This has the potential to be used to aid diagnostics and treatment planning.
authors.affiliation: Ocular Biomechanics and Biomaterials Group, School of Engineering, University of Liverpool, Brownlow Hill, Liverpool, L69 3GH UK ; Department of Eye and Vision Science, University of Liverpool, 3rd Floor, UCD Building, Daulby Street, Liverpool, L69 3GA UK.
authors.forename: Dominic
authors.initials: D
authors.lastname: Williams
authors.affiliation: Department of Eye and Vision Science, University of Liverpool, 3rd Floor, UCD Building, Daulby Street, Liverpool, L69 3GA UK.
authors.forename: Yalin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, No. 270, Xueyuanxi Road, Wenzhou City, Zhejiang Province 325027 China.
authors.forename: Fangjun
authors.initials: F
authors.lastname: Bao
authors.affiliation: Ocular Biomechanics and Biomaterials Group, School of Engineering, University of Liverpool, Brownlow Hill, Liverpool, L69 3GH UK.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Elsheikh
keywords: Anterior segment; Cornea; Graph cut; Image segmentation; Optical coherence tomography; Shape prior