title: Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information.
abstract: Extensive drug discovery efforts have yielded many approved and candidate drugs targeting various targets in different biological pathways. Several freely accessible databases provide the drug, target and drug-targeted pathway information for facilitating drug discovery efforts, but there is an insufficient coverage of the clinical trial drugs and the drug-targeted pathways. Here, we describe an update of the Therapeutic Target Database (TTD) previously featured in NAR. The updated contents include: (i) significantly increased coverage of the clinical trial targets and drugs (1.6 and 2.3 times of the previous release, respectively), (ii) cross-links of most TTD target and drug entries to the corresponding pathway entries of KEGG, MetaCyc/BioCyc, NetPath, PANTHER pathway, Pathway Interaction Database (PID), PathWhiz, Reactome and WikiPathways, (iii) the convenient access of the multiple targets and drugs cross-linked to each of these pathway entries and (iv) the recently emerged approved and investigative drugs. This update makes TTD a more useful resource to complement other databases for facilitating the drug discovery efforts. TTD is accessible at http://bidd.nus.edu.sg/group/ttd/ttd.asp.
authors.affiliation: Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore.
authors.forename: Chu
authors.initials: C
authors.lastname: Qin
authors.affiliation: Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China.
authors.forename: Ying Hong
authors.initials: YH
authors.lastname: Li
authors.affiliation: Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore.
authors.forename: Lin
authors.initials: L
authors.lastname: Tao
authors.affiliation: Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China.
authors.forename: Chun Yan
authors.initials: CY
authors.lastname: Yu
authors.affiliation: College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Zhejiang Key Laboratory of Gastro-intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China zhufeng@cqu.edu.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore csccyz@nus.edu.sg.
authors.forename: Yu Zong
authors.initials: YZ
authors.lastname: Chen
mesh_terms: D002986:Clinical Trials as Topic; D062313:Databases, Pharmaceutical; D055808:Drug Discovery; D020407:Internet; D015398:Signal Transduction / Q000187:drug effects