title: [Differential effects of attention deficit/hyperactivity disorder subtypes in event-related potentials].
abstract: BACKGROUND
  To better understand the neurophysiological substrates in attention deficit/hyperactivity disorder (ADHD), a study was performed on of event-related potentials (ERPs) in Colombian patients with inattentive and combined ADHD.
  
  
  METHODS
  A case-control, cross-sectional study was designed. The sample was composed of 180 subjects between 5 and 15 years of age (mean, 9.25±2.6), from local schools in Manizales. The sample was divided equally in ADHD or control groups and the subjects were paired by age and gender. The diagnosis was made using the DSM-IV-TR criteria, the Conners and WISC-III test, a psychiatric interview (MINIKID), and a medical evaluation. ERPs were recorded in a visual and auditory passive oddball paradigm. Latency and amplitude of N100, N200 and P300 components for common and rare stimuli were used for statistical comparisons.
  
  
  RESULTS
  ADHD subjects show differences in the N200 amplitude and P300 latency in the auditory task. The N200 amplitude was reduced in response to visual stimuli. ADHD subjects with combined symptoms show a delayed P300 in response to auditory stimuli, whereas inattentive subjects exhibited differences in the amplitude of N100 and N200. Combined ADHD patients showed longer N100 latency and smaller N200-P300 amplitude compared to inattentive ADHD subjects.
  
  
  CONCLUSIONS
  The results show differences in the event-related potentials between combined and inattentive ADHD subjects.
authors.affiliation: Laboratorio de Neurofisiología, Universidad Autónoma de Manizales, Manizales, Colombia.
authors.forename: Lukas
authors.initials: L
authors.lastname: Tamayo-Orrego
authors.affiliation: Laboratorio de Neurofisiología, Universidad Autónoma de Manizales, Manizales, Colombia.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Osorio Forero
authors.affiliation: Laboratorio de Neurofisiología, Universidad Autónoma de Manizales, Manizales, Colombia.
authors.forename: Lina Paola
authors.initials: LP
authors.lastname: Quintero Giraldo
authors.affiliation: Universidad Nacional de Colombia, Sede Manizales, Manizales, Colombia.
authors.forename: José Hernán
authors.initials: JH
authors.lastname: Parra Sánchez
authors.affiliation: Facultad de Ciencias Sociales y Humanas, Universidad de Manizales, Manizales, Colombia.
authors.forename: Vilma
authors.initials: V
authors.lastname: Varela
authors.affiliation: Laboratorio de Neurofisiología, Universidad Autónoma de Manizales, Manizales, Colombia. Electronic address: francia46@gmail.com.
authors.forename: Francia
authors.initials: F
authors.lastname: Restrepo
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003105:Colombia; D003430:Cross-Sectional Studies; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male
keywords: Attention deficit/hyperactivity disorder; Clinical subtypes; Event-related potentials; Potenciales evocados relacionados con eventos; Subtipos clínicos; Trastorno por déficit de atención e hiperactividad