title: Anterior segment spectral domain optical coherence tomography imaging of patients with anterior scleritis.
abstract: The purpose of the study was to describe the findings seen on anterior segment spectral domain optical coherence tomography (SD-OCT) in patients with anterior scleritis and determine the feasibility of using SD-OCT to image and grade the degree of scleral inflammation and monitor response to treatment. All patients underwent slit lamp examination by a uveitis specialist, and the degree of scleral inflammation was recorded. Spectral domain OCT imaging was then performed of the conjunctiva and scleral tissue using a standardized acquisition protocol. The scans were graded and compared to clinical findings. Twenty-eight patients with anterior scleritis and ten patients without ocular disease were included in the study. Seventeen of the scleritis patients were followed longitudinally. Common findings on SD-OCT in patients with active scleritis included changes in hyporeflectivity within the sclera, nodules, and visible vessels within the sclera. There was significant variation in findings on SD-OCT within each clinical grade of active scleritis. These changes on SD-OCT improved with treatment and clinical improvement. SD-OCT imaging provided various objective measures that could be used in the future to grade inflammatory activity in patients with anterior scleritis. Longitudinal imaging of patients with active scleritis demonstrated that SD-OCT may have great utility in monitoring response to treatment.
authors.affiliation: Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Ave i32, Cleveland, OH, 44195, USA. ashleigh.levison@gmail.com.
authors.forename: Ashleigh L
authors.initials: AL
authors.lastname: Levison
authors.affiliation: Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Ave i32, Cleveland, OH, 44195, USA.
authors.forename: Careen Y
authors.initials: CY
authors.lastname: Lowder
authors.affiliation: Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Ave i32, Cleveland, OH, 44195, USA.
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Baynes
authors.affiliation: Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Ave i32, Cleveland, OH, 44195, USA.
authors.forename: Peter K
authors.initials: PK
authors.lastname: Kaiser
authors.affiliation: Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Ave i32, Cleveland, OH, 44195, USA.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Srivastava
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015423:Scleritis / Q000145:classification / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence
keywords: Inflammation; Optical coherence tomography; Scleritis; Scleromalacia