title: Clinical Utility of an Automated Pupillometer in Patients with Acute Brain Lesion.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the clinical utility and validity of using a pupillometer to assess patients with acute brain lesions.
  
  
  METHODS
  Pupillary examinations using an automated pupillometer (NeurOptics®NPi™-100 Pupillometer) were performed every 4 hours and were simultaneously assessed using the Glasgow Coma Scale (GCS) and for intracranial pressure (ICP), from admission to discharge or expire in neuro-intensive care unit (NICU). Manual pupillary examinations were also recorded for comparison. By comparing these data, we evaluated the validity of using automated pupillometers to predict clinical outcomes.
  
  
  RESULTS
  The mean values of the Neurologic Pupillary index (NPi) were different in the groups examined manually. The GCS correlated well with NPi values, especially in severe brain injury patients (GCS below 9). However, the NPi values were weakly correlated with intracranial pressure (ICP) when the ICP was lower than 30 cm H2O. The NPi value was not affected by age or intensity of illumination. In patients with a "poor" prognosis who had a Glasgow Outcome Scale (GOS) of 1 or 2, the mean initial NPi score was 0.88±1.68, whereas the value was 3.89±0.97 in patients with a "favorable" prognosis who had a GOS greater than 2 (p<0.001). For predicting clinical outcomes, the initial NPi value of 3.4 had the highest sensitivity and specificity.
  
  
  CONCLUSIONS
  An automated pupillometer can serve as a simple and useful tool for the accurate measurement of pupillary reactivity in patients with acute brain lesions.
authors.affiliation: Department of Neurosurgery, Konkuk University Medical Center, Seoul, Korea.
authors.forename: Jeong Goo
authors.initials: JG
authors.lastname: Park
authors.affiliation: Department of Neurosurgery, Konkuk University Medical Center, Seoul, Korea.
authors.forename: Chang Taek
authors.initials: CT
authors.lastname: Moon
authors.affiliation: Department of Neurosurgery, Konkuk University Medical Center, Seoul, Korea.
authors.forename: Dong Sun
authors.initials: DS
authors.lastname: Park
authors.affiliation: Department of Neurosurgery, Konkuk University Medical Center, Seoul, Korea.
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Song
keywords: Light reflex; Neurologic Pupillary Index; Pupillometer