title: BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs.
abstract: The biopharmaceutics drug disposition classification system was developed in 2005 by Wu and Benet as a tool to predict metabolizing enzyme and drug transporter effects on drug disposition. The system was modified from the biopharmaceutics classification system and classifies drugs according to their extent of metabolism and their water solubility. By 2010, Benet et al. had classified over 900 drugs. In this paper, we incorporate more than 175 drugs into the system and amend the classification of 13 drugs. We discuss current and additional applications of BDDCS, which include predicting drug-drug and endogenous substrate interactions, pharmacogenomic effects, food effects, elimination routes, central nervous system exposure, toxicity, and environmental impacts of drugs. When predictions and classes are not aligned, the system detects an error and is able to self-correct, generally indicating a problem with initial class assignment and/or measurements determining such assignments.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 533 Parnassus Ave., Room U-68, San Francisco, California, 94143-0912, USA.
authors.forename: Chelsea M
authors.initials: CM
authors.lastname: Hosey
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 533 Parnassus Ave., Room U-68, San Francisco, California, 94143-0912, USA.
authors.forename: Rosa
authors.initials: R
authors.lastname: Chan
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 533 Parnassus Ave., Room U-68, San Francisco, California, 94143-0912, USA. leslie.benet@ucsf.edu.
authors.forename: Leslie Z
authors.initials: LZ
authors.lastname: Benet
mesh_terms: D001702:Biopharmaceutics / Q000145:classification*; D002352:Carrier Proteins / Q000378:metabolism; D004347:Drug Interactions; D004777:Environment; D018565:Food-Drug Interactions; D006801:Humans; D004364:Pharmaceutical Preparations / Q000145:classification* / Q000378:metabolism; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D012995:Solubility; D014018:Tissue Distribution
chemical_list: D002352:Carrier Proteins; D004364:Pharmaceutical Preparations
keywords: BDDCS; biopharmaceutics drug disposition classification system; disposition; drug development; drug transport