title: Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes.
abstract: Aging research is a multi-disciplinary field encompassing knowledge from many areas of basic, applied and clinical research. Age-related processes occur on molecular, cellular, tissue, organ, system, organismal and even psychological levels, trigger the onset of multiple debilitating diseases and lead to a loss of function, and there is a need for a unified knowledge repository designed to track, analyze and visualize the cause and effect relationships and interactions between the many elements and processes on all levels. Aging Chart (http://agingchart.org/) is a new, community-curated collection of aging pathways and knowledge that provides a platform for rapid exploratory analysis. Building on an initial content base constructed by a team of experts from peer-reviewed literature, users can integrate new data into biological pathway diagrams for a visible, intuitive, top-down framework of aging processes that fosters knowledge-building and collaboration. As the body of knowledge in aging research is rapidly increasing, an open visual encyclopedia of aging processes will be useful to both the new entrants and experts in the field.
authors.affiliation: Laboratory of molecular radiobiology and gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia Laboratory of postgenomic studies, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia School of Systems Biology, George Mason University, VA, Manassas, 20110, USA Branch of N.I.Pirogov Russian State Medical University "Scientific Clinical Center of Gerontology", Moscow, 117997, Russia amoskalev@list.ru.
authors.forename: Alexey
authors.initials: A
authors.lastname: Moskalev
authors.affiliation: Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia Laboratory of postgenomic studies, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Zhikrivetskaya
authors.affiliation: Laboratory of molecular radiobiology and gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia.
authors.forename: Mikhail
authors.identifier: http://orcid.org/0000-0002-4625-6488
authors.initials: M
authors.lastname: Shaposhnikov
authors.affiliation: Laboratory of molecular radiobiology and gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia.
authors.forename: Evgenia
authors.identifier: http://orcid.org/0000-0001-6090-8254
authors.initials: E
authors.lastname: Dobrovolskaya
authors.affiliation: Xpansa, Conzl OU, Mustamae Tee 5, Tallinn, 10616, Estonia Infinity Sciences, Inc, 16192 Coastal Highway, Lewes, Delaware, County of Sussex, 19958, USA amoskalev@list.ru.
authors.forename: Roman
authors.identifier: http://orcid.org/0000-0002-9985-9493
authors.initials: R
authors.lastname: Gurinovich
authors.affiliation: Xpansa, Conzl OU, Mustamae Tee 5, Tallinn, 10616, Estonia Infinity Sciences, Inc, 16192 Coastal Highway, Lewes, Delaware, County of Sussex, 19958, USA.
authors.forename: Oleg
authors.initials: O
authors.lastname: Kuryan
authors.affiliation: Xpansa, Conzl OU, Mustamae Tee 5, Tallinn, 10616, Estonia Infinity Sciences, Inc, 16192 Coastal Highway, Lewes, Delaware, County of Sussex, 19958, USA.
authors.forename: Aleksandr
authors.identifier: http://orcid.org/0000-0001-6551-7658
authors.initials: A
authors.lastname: Pashuk
authors.affiliation: Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
authors.forename: Leslie C
authors.initials: LC
authors.lastname: Jellen
authors.affiliation: D.Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology, Samory Machela 1, Moscow, 117997, Russia Insilico Medicine, Inc, Johns Hopkins University, ETC, B310, Baltimore, MD, 21218, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Aliper
authors.affiliation: The Biogerontology Research Foundation, 2354 Chynoweth House, Trevissome Park, Blackwater, Truro, Cornwall TR4 8UN, UK.
authors.forename: Alex
authors.initials: A
authors.lastname: Peregudov
authors.affiliation: Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia D.Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology, Samory Machela 1, Moscow, 117997, Russia Insilico Medicine, Inc, Johns Hopkins University, ETC, B310, Baltimore, MD, 21218, USA The Biogerontology Research Foundation, 2354 Chynoweth House, Trevissome Park, Blackwater, Truro, Cornwall TR4 8UN, UK amoskalev@list.ru.
authors.forename: Alex
authors.identifier: http://orcid.org/0000-0001-7067-8966
authors.initials: A
authors.lastname: Zhavoronkov
mesh_terms: D000375:Aging / Q000235:genetics / Q000502:physiology*; D016208:Databases, Factual; D004194:Disease; D006801:Humans; D015398:Signal Transduction