title: Effect of Combined Stress on Morphological Changes and Expression of NO Synthases in Rat Ventral Hippocampus.
abstract: Adult rats were subjected to 7-day combined stress with stochastic changes of stressors of different modalities (noise, vibration, pulsating bright light) along with mobility restriction and elevated temperature in the chamber during stress exposures (daily 30-min sessions). Circulatory disorders, inhibition of endothelial NO-synthase expression in endothelial cells of the microcirculatory bed, perivascular edema, pronounced degenerative changes, and enhanced expression of inducible NO synthase in CA3 pyramidal neurons in the ventral hippocampus of stressed 12-month-old rats were observed. These findings can attest to the involvement NOdependent mechanisms and different contribution of NO synthase isoforms into the formation of hippocampal neuronal damage.
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia. alexey-smirnov@rambler.ru.|Volgograd Medical Research Center, Volgograd, Russia. alexey-smirnov@rambler.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnov
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.|Volgograd Medical Research Center, Volgograd, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Shmidt
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: M R
authors.initials: MR
authors.lastname: Ekova
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: D S
authors.initials: DS
authors.lastname: Mednikov
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: D D
authors.initials: DD
authors.lastname: Borodin
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001929:Brain Edema / Q000201:enzymology / Q000209:etiology / Q000473:pathology; D056654:CA3 Region, Hippocampal / Q000098:blood supply / Q000201:enzymology* / Q000648:ultrastructure; D042783:Endothelial Cells / Q000201:enzymology; D004790:Enzyme Induction; D008027:Light / Q000009:adverse effects; D008297:Male; D008833:Microcirculation; D009410:Nerve Degeneration / Q000201:enzymology / Q000209:etiology / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis* / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000096:biosynthesis* / Q000235:genetics; D009622:Noise / Q000009:adverse effects; D017966:Pyramidal Cells / Q000201:enzymology* / Q000648:ultrastructure; D051381:Rats; D012149:Restraint, Physical / Q000009:adverse effects; D013312:Stress, Physiological; D013696:Temperature; D014732:Vibration / Q000009:adverse effects
chemical_list: D009419:Nerve Tissue Proteins; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; C496318:Nos2 protein, rat; C496316:Nos3 protein, rat
keywords: endothelial NO synthase; hippocampus; inducible NO synthase; rat; stress