title: The pivotal role of the mentor in triggering the research on Complement system.
abstract: Despite the fact that was one of the first systems to be discovered and investigated in the innate immunity, Complement is continuing to receive growing attention by the scientific community. Complement is involved in several diseases such as diabetes, atherosclerosis or Systemic Lupus Erythematous. Successful therapeutic intervention in treating Complement-mediated diseases such as Hemolytic Uremic Syndrome represent a promising advance to continue the research on Complement to develop specific inhibitors for treating human diseases.
authors.affiliation: Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy. Electronic address: giuseppe.castellano@uniba.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Castellano
mesh_terms: D000486:Allergy and Immunology / Q000193:education; D000818:Animals; D035843:Biomedical Research / Q000266:history; D003165:Complement System Proteins / Q000235:genetics*; D003299:Cooperative Behavior; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000276:immunology / Q000473:pathology; D005786:Gene Expression Regulation / Q000276:immunology*; D006463:Hemolytic-Uremic Syndrome / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D051379:Mice; D015427:Reperfusion Injury / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D013045:Species Specificity; D013552:Swine
chemical_list: D003165:Complement System Proteins
keywords: Complement; Ischemia/reperfusion injury