title: The relationships between hematogram and metabolic syndrome in elderly subgroups: A Taiwan cohort study.
abstract: BACKGROUND
  Abnormal hematogram components could predict future metabolic syndrome (MetS) and diabetes. However, there was no study focusing on the subgroups of the elderly. In this ten-year longitudinal study, we investigated the association between hematogram components, future MetS and diabetes in the elderly.
  
  
  METHODS
  Subjects above 65 years were divided into three groups by age (young old: ≧65 and <75, old-old: ≧75 and <85 and oldest-old ≧85).By using multiple logistic regression, the hazard ratio (HR) of higher hemoglobin (Hb), white blood cell count (WBCC) and platelet (PLT) to have future MetS and diabetes were evaluated.
  
  
  RESULTS
  There were 15169 subjects in the young-old group, 3536 in the old-old group and 202 in the oldest-old group, respectively. After 10 years follow-up, only higher WBCC and Hb levels (>5.0×10(3), 15 g/dL, respectively) was correlated to future MetS in young-old men (adjusted HR: 1.242, 1.166, respectively). In addition, higher Hb (>13.7 g/dL) was originally associated with future MetS in young-old and old-old women but failed in adjusted HR. Moreover, the PLT did not correlate with any of the endpoints. Finally, higher chances of diabetes could be noted with higher WBCC in both men and women (adjusted HR: 1.404, 1.206, respectively).
  
  
  CONCLUSIONS
  The associations between hematogram and future MetS were different in each subgroup of the elderly. Higher WBCC and Hb levels could predict future MetS in young-old men. Moreover, Higher WBCC is positively correlated with future diabetes in both young-old men and women.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan, ROC; Department of Internal Medicine, Armed Forces Taichung General Hospital, No. 348, Sec. 2, Zhongshan Rd., Taiping Dist., Taichung City 411, Taiwan, ROC.
authors.forename: Tsung-Ju
authors.initials: TJ
authors.lastname: Chuang
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan, ROC.
authors.forename: Jhih-Syuan
authors.initials: JS
authors.lastname: Liu
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan, ROC.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Li
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan, ROC.
authors.forename: Hsiao wen
authors.initials: Hw
authors.lastname: Chang
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan, ROC.
authors.forename: Chang-Hsun
authors.initials: CH
authors.lastname: Hsieh
authors.affiliation: Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan, ROC.
authors.forename: Jin-Biou
authors.initials: JB
authors.lastname: Chang
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu Dist., Taipei City 114, Taiwan, ROC.
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Hung
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, No. 510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City 242, Taiwan, ROC.
authors.forename: Dee
authors.initials: D
authors.lastname: Pei
authors.affiliation: Department and Institute of Life-Science, Fu-Jen Catholic University, No. 510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City 242, Taiwan, ROC.
authors.forename: Yao-Jen
authors.initials: YJ
authors.lastname: Liang
authors.affiliation: Department of Pathology, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, No. 510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City 242, Taiwan, ROC. Electronic address: anthonypatho@gmail.com.
authors.forename: Yen-Lin
authors.initials: YL
authors.lastname: Chen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001772:Blood Cell Count / Q000379:methods*; D015992:Body Mass Index; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis*; D012737:Sex Factors; D013624:Taiwan
chemical_list: D006454:Hemoglobins
keywords: Elderly; Hematogram; Metabolic syndrome