title: Tumors induce immune tolerance through activation of β-catenin/TCF4 signaling in dendritic cells: A novel therapeutic target for cancer immunotherapy.
abstract: Tumors promote immune suppression and dendritic cells (DCs) play a key role in this. However, signaling networks that program DCs to induce immune suppression are unknown. In our recent study, we showed that tumors activate β-catenin/TCF4 in DCs programming them to a regulatory state, which promotes T regulatory responses while suppresses effector T cell responses. Thus, targeting DCs-β-catenin pathway represents a promising target for anticancer immunotherapy.
authors.affiliation: Cancer Immunology; Inflammation, and Tolerance Program; GRU Cancer Center; Georgia Regents University ; Augusta, GA USA.
authors.forename: Amol
authors.initials: A
authors.lastname: Suryawanshi
authors.affiliation: Cancer Immunology; Inflammation, and Tolerance Program; GRU Cancer Center; Georgia Regents University ; Augusta, GA USA.
authors.forename: Santhakumar
authors.initials: S
authors.lastname: Manicassamy
keywords: immune suppression, dendritic cells, cancer immunotherapy, Wnt, β-catenin, retionic acid, regulatory T cells