title: Lack of Association Between Polymorphisms in AGT and ATR1 and IgA Nephropathy in a Chinese Population.
abstract: OBJECTIVE
  The mechanism of immunoglobulin A nephropathy (IgAN) remains unclear. Genetic factors may be associated with the risk of IgAN. This study aims to identify the possible association of M268T (rs699) in the Angiotensinogen (AGT) gene and A1166C (rs5186) in the Angiotensin II receptor type 1 (ATR1) gene with IgAN risk.
  
  
  METHODS
  Study subjects included 351 patients with IgAN and 310 controls from the Chinese population. The tag SNPs (tSNPs) were genotyped by Sequenom MassARRAY RS1000. Statistical analysis of the association between tSNPs and IgAN was performed using the χ(2) test and SNPStats software.
  
  
  RESULTS
  The AGT (M268T) genotypes were distributed in IgAN as CC 61.9%, CT 34.8%, and TT 3.2%, while in controls CC 64.1%, CT 31.3%, and TT 4.6%. Distribution of ATR1 (A1166C) was AA 87.7%, CA 12.3%, and CC 0%, while in controls AA 87.2%, CA 12%, and CC 0.8%. We further analyzed tSNPs under different inheritance models and found that there were no significant differences in the genotypes and allele frequencies of rs699 and rs5186 between two groups (p > 0.05). We also analyzed tSNPs based on the rate of pressure, proteinuria and Lee's classification, and no significant differences were found in the models (p > 0.05).
  
  
  CONCLUSIONS
  rs699 in the AGT gene and rs5186 in the ATR1 gene were not associated with the risk and clinical outcomes of IgAN.
authors.affiliation: 1 Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.affiliation: 1 Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Qiao-Ling
authors.initials: QL
authors.lastname: Yu
authors.affiliation: 1 Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Rong-Guo
authors.initials: RG
authors.lastname: Fu
authors.affiliation: 1 Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Lin-Ting
authors.initials: LT
authors.lastname: Wei
authors.affiliation: 2 Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: 1 Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Feng-Ming
authors.initials: FM
authors.lastname: Dong
authors.affiliation: 1 Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.affiliation: 2 Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Peng-Tao
authors.initials: PT
authors.lastname: Yang
authors.affiliation: 2 Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Xing-Han
authors.initials: XH
authors.lastname: Liu
authors.affiliation: 2 Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Dai
mesh_terms: D000328:Adult; D000808:Angiotensinogen / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C534931:AGT protein, human; C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen