title: Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress.
abstract: In order to investigate the possible involvement of endoplasmic reticulum (ER) stress in the developmental origins of hepatic steatosis associated with undernourishment in utero, we herein employed a fetal undernourishment mouse model by maternal caloric restriction in three cohorts; cohort 1) assessment of hepatic steatosis and the ER stress response at 9 weeks of age (wks) before a high fat diet (HFD), cohort 2) assessment of hepatic steatosis and the ER stress response on a HFD at 17 wks, cohort 3) assessment of hepatic steatosis and the ER stress response at 22 wks on a HFD after the alleviation of ER stress with a chemical chaperone, tauroursodeoxycholic acid (TUDCA), from 17 wks to 22 wks. Undernourishment in utero significantly deteriorated hepatic steatosis and led to the significant integration of the ER stress response on a HFD at 17 wks. The alleviation of ER stress by the TUDCA treatment significantly improved the parameters of hepatic steatosis in pups with undernourishment in utero, but not in those with normal nourishment in utero at 22 wks. These results suggest the pivotal involvement of the integration of ER stress in the developmental origins of hepatic steatosis in association with undernourishment in utero.
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Muramatsu-Kato
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Itoh
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kohmura-Kobayashi
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 Japan.
authors.forename: Urmi J
authors.initials: UJ
authors.lastname: Ferdous
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 Japan.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Tamura
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 Japan.
authors.forename: Chizuko
authors.initials: C
authors.lastname: Yaguchi
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 Japan.
authors.forename: Kazunao
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Preemptive Medicine and Metabolism, Tokyo 113-8510, Japan.
authors.forename: Koshi
authors.initials: K
authors.lastname: Hashimoto
authors.affiliation: Department of Organ Network and Metabolism, Tokyo 113-8510, Japan.|Japan Science and Technology Agency, PRESTO, Tokyo, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Suganami
authors.affiliation: Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.|Japan Agency for Medical Research and Development, CREST, Tokyo, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ogawa
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 Japan.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Kanayama
mesh_terms: D000818:Animals; D002452:Cell Count; D059305:Diet, High-Fat; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D005234:Fatty Liver / Q000097:blood / Q000209:etiology* / Q000473:pathology; D005260:Female; D006909:Hydroxyproline / Q000378:metabolism; D007249:Inflammation / Q000150:complications / Q000473:pathology; D007328:Insulin / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D044342:Malnutrition / Q000150:complications* / Q000473:pathology; D008810:Mice, Inbred C57BL; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology; D000637:Transaminases / Q000378:metabolism
chemical_list: D007328:Insulin; D008055:Lipids; D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine; D000637:Transaminases; D006909:Hydroxyproline