title: Implications for reactive oxygen species in schizophrenia pathogenesis.
abstract: Oxidative stress is a well-recognized participant in the pathophysiology of multiple brain disorders, particularly neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. While not a dementia, a wide body of evidence has also been accumulating for aberrant reactive oxygen species and inflammation in schizophrenia. Here we highlight roles for oxidative stress as a common mechanism by which varied genetic and epidemiologic risk factors impact upon neurodevelopmental processes that underlie the schizophrenia syndrome. While there is longstanding evidence that schizophrenia may not have a single causative lesion, a common pathway involving oxidative stress opens the possibility for intervention at susceptible phases.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 3-166, Baltimore, MD 21287, USA.
authors.forename: Minori
authors.initials: M
authors.lastname: Koga
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 3-166, Baltimore, MD 21287, USA.
authors.forename: Anthony V
authors.initials: AV
authors.lastname: Serritella
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 3-166, Baltimore, MD 21287, USA.
authors.forename: Akira
authors.initials: A
authors.lastname: Sawa
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 3-166, Baltimore, MD 21287, USA. Electronic address: tsedlak@jhmi.edu.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Sedlak
mesh_terms: D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D018384:Oxidative Stress; D011618:Psychotic Disorders / Q000276:immunology / Q000378:metabolism; D017382:Reactive Oxygen Species; D012559:Schizophrenia / Q000276:immunology / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species
keywords: Glutathione; Inflammation; Microglia; Oxidative stress; Psychosis; Schizophrenia