title: Clinical efficacy and tolerability of two Japanese traditional herbal medicines, Hachimi-jio-gan and Gosha-jinki-gan, for lower urinary tract symptoms with cold sensitivity.
abstract: We evaluated the efficacy and tolerability of Hachimi-jio-gan (HJG; bā wèi dì huáng wán) and Gosha-jinki-gan (GJG; jì shēng shèn qì wán), two traditional Japanese medicines, in 60 patients with lower urinary tract symptoms (LUTS) having cold sensitivity unresponsive to α1-blockers or antimuscarinic drugs. All patients received a mixture of HJG or GJG for 12 weeks in addition to α1-blockers or antimuscarinic drugs as add-on therapy. International Prostate Symptom Score, International Prostate Symptom Score-Quality of Life, Benign Prostatic Hyperplasia Impact Index, and the number of nocturnal voids were statistically much improved. However, there was no change in maximal urinary flow rate and post-void residual urine. Urinary 8-hydroxy-2-deoxyguanosine was statistically greatly improved from baseline after treatment in the HJG group compared to the GJG group. Adverse reactions were observed in 8.3% of patients, but all reactions were mild. Both HJG and GJG mixtures can serve as safe and effective potential therapeutic alternatives in patients with LUTS and cold sensitivity unresponsive to α1-blockers or antimuscarinic drugs. Additionally, HJG mixture was found to have anti-oxidative activity, and therefore further long-term clinical investigations are needed to examine its anti-aging effects in addition to its effect on urinary symptoms.
authors.affiliation: Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagi
authors.affiliation: Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Sato
authors.affiliation: Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
authors.forename: Kojiro
authors.initials: K
authors.lastname: Nishio
authors.affiliation: Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
authors.forename: Gaku
authors.initials: G
authors.lastname: Arai
authors.affiliation: Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Soh
authors.affiliation: Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okada
keywords: Cold sensitivity; Gosha-jinki-gan; Hachimi-jio-gan; Lower urinary tract symptoms; Oxidative stress