title: Can formulation and drug delivery reduce attrition during drug discovery and development-review of feasibility, benefits and challenges.
abstract: Drug discovery and development has become longer and costlier process. The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards "me too" drugs and improved generics (505(b) (2)) fillings. The discontinuance of molecules at late stage clinical trials is common these years. The molecules are withdrawn at various stages of discovery and development process for reasons such as poor ADME properties, lack of efficacy and safety reasons. Hence this review focuses on possible applications of formulation and drug delivery to salvage molecules and improve the drugability. The formulation and drug delivery technologies are suitable for addressing various issues contributing to attrition are discussed in detail.
authors.affiliation: Western Centre for Drug Development, Western University of Health Sciences, Pomona, CA 91766, USA.
authors.forename: S
authors.initials: S
authors.lastname: Basavaraj
authors.affiliation: Western Centre for Drug Development, Western University of Health Sciences, Pomona, CA 91766, USA.
authors.forename: Guru V
authors.initials: GV
authors.lastname: Betageri
keywords: Drug delivery technology; Drug discovery and development; Drugability; Formulation