title: Platelet derived growth factor inhibitors: A potential therapeutic approach for ocular neovascularization.
abstract: Retinochoroidal vascular diseases are the leading causes of blindness in the developed world. They include diabetic retinopathy (DR), retinal vein occlusion, retinopathy of prematurity, age-related macular degeneration (AMD), and pathological myopia, among many others. Several different therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factor (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF plays an important role in the angiogenesis cascade that is activated in retinochoroidal vascular diseases. The mechanism of action, side effects, efficacy, and the potential synergistic role of these agents in combination with other treatment options is discussed. The future of treatment of retinochoroidal vascular diseases, particularly AMD, has become more exciting due to agents such as PDGF antagonists.
authors.affiliation: Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sadiq
authors.affiliation: Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Hanout
authors.affiliation: Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Salman
authors.initials: S
authors.lastname: Sarwar
authors.affiliation: Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hassan
authors.affiliation: Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Do
authors.affiliation: Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Quan Dong
authors.initials: QD
authors.lastname: Nguyen
authors.affiliation: Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Yasir Jamal
authors.initials: YJ
authors.lastname: Sepah
keywords: Age related macular degeneration; Diabetic retinopathy; PDGF; Platelet derived growth factor; Retinal vascular disease