title: Twin Anemia-Polycythemia Sequence: Perinatal Management and Outcome.
abstract: OBJECTIVE
  To determine the perinatal outcome of monochorionic twin pregnancies complicated by twin anemia-polycythemia sequence (TAPS).
  
  
  METHODS
  All monochorionic twins diagnosed with TAPS between 2011 and 2014 were included. Each twin pair with TAPS (study group) was compared with 2 uncomplicated monochorionic twin pairs who were matched for gestational age at delivery (control group). Neonatal morbidity and mortality were evaluated.
  
  
  RESULTS
  During the study period, 179 monochorionic twins were followed at our center, of whom 46 underwent laser ablation due to twin-to-twin transfusion syndrome. TAPS was diagnosed in 10 cases; 8 of them were spontaneous, and 2 occurred following laser surgery. Out of 7 patients diagnosed prenatally with TAPS, 5 cases were managed expectantly, and 2 cases were treated with intrauterine blood transfusion. The rates of severe and mild central nervous system lesions on postnatal ultrasound were similar in the TAPS group and control group (5.0 vs. 2.5%, p = 0.61, and 5.0 vs. 12.5%, p = 0.25, respectively). Additionally, severe neonatal morbidity was comparable between the groups. All neonates were alive at 1 month of age.
  
  
  CONCLUSIONS
  The neonatal outcome of monocohorionic twins affected by TAPS is favorable and comparable to gestational age-matched uncomplicated monochorionic twins.
authors.affiliation: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Ashwal
authors.forename: Yoav
authors.initials: Y
authors.lastname: Yinon
authors.forename: Michal
authors.initials: M
authors.lastname: Fishel-Bartal
authors.forename: Abraham
authors.initials: A
authors.lastname: Tsur
authors.forename: Benjamin
authors.initials: B
authors.lastname: Chayen
authors.forename: Boaz
authors.initials: B
authors.lastname: Weisz
authors.forename: Shlomo
authors.initials: S
authors.lastname: Lipitz
mesh_terms: D000328:Adult; D001805:Blood Transfusion, Intrauterine; D005260:Female; D005330:Fetofetal Transfusion / Q000000981:diagnostic imaging / Q000601:surgery / Q000628:therapy*; D005332:Fetoscopy; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D016896:Treatment Outcome