title: [Formula Optimization in Renshen Jianxin Capsule Based on Uniform Design and Anti-myocardial Ischemia Effect].
abstract: OBJECTIVE
  To realize quadratic formula optimization of Renshen Jianxin Capsule (RJC) by screening Chinese herbs with major anti-myocardial ischemia effect in RJC and optimize their optimal dosages.
  
  
  METHODS
  By following "uniform design-pharmacodynamic experiment-mathematical modeling-formula optimization", authors employed U10(10(8)) uniform design in the experiment. Eight Chinese herbs contained in RJC were taken as observatory factors. Electrocardiograph (ECG) changes of myocardial ischemia induced by isoproterenol were taken as pharmacodynamic indices. The mathematical model between herbal factors and pharmacodynamic indices was established using stepwise regression analysis to screen Chinese herbs with major anti-myocardial ischemia effect. Their optimal dosages were optimized using the grid algorithm.
  
  
  RESULTS
  The regression equation was y =1. 7889 -0. 3247 Ginseng xSalvia Miltiorrhiza -0. 0663 Astragalus membranaceus xOriental Waterplantain tuber. Forecasting factors included were Ginseng, Salvia Miltiorrhiza, Astragalus membranaceus, and Oriental Waterplantain tuber. The optimal formula dosage calculated by the grid algorithm was Ginseng 1. 62 g, Astragalus membranaceus 4. 62 g, Salvia Miltiorrhiza 2. 43 g, and Oriental Waterplantain tuber 1. 66 g.
  
  
  CONCLUSIONS
  Uniform design combined with stepwise regression analysis and grid algorithm were able to realize quadratic formula optimization of RJC.
authors.forename: Chua-hua
authors.initials: CH
authors.lastname: Yang
authors.forename: Yun-lun
authors.initials: YL
authors.lastname: Li
authors.forename: Hai-qiang
authors.initials: HQ
authors.lastname: Jiang
authors.forename: Lei
authors.initials: L
authors.lastname: Nie
authors.forename: Jiang-qing
authors.initials: JQ
authors.lastname: Ju
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Xue-yi
authors.initials: XY
authors.lastname: Ding
authors.forename: Shi-jun
authors.initials: SJ
authors.lastname: Zhang
mesh_terms: D027885:Astragalus propinquus; D002626:Chemistry, Pharmaceutical / Q000592:standards*; D003324:Coronary Artery Disease; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004562:Electrocardiography; D006801:Humans; D007545:Isoproterenol; D017202:Myocardial Ischemia / Q000188:drug therapy*; D005894:Panax; D027561:Salvia miltiorrhiza
chemical_list: D004365:Drugs, Chinese Herbal; D007545:Isoproterenol