title: High dose of formaldehyde exposure during pregnancy increases neutrophils lung influx evoked by ovalbumin in the offspring.
abstract: OBJECTIVE
  Considering that asthma might have their onset in the intrauterine life and the exposure to FA during pregnancy interferes in the immune system of offspring, here we hypothesized that high dose of FA exposure during pregnancy could to contribute for development and severity of asthma in the offspring.
  
  
  METHODS
  Pregnant Wistar rats were submitted to FA inhalation (6.13 mg/m(3), 1 h/day, 5 days/week, for 21 days) or vehicle (distillated water). After 30 days of birth, the offspring was sensitized with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1%, 15 min, 3 days). After 24 h the OVA challenge, the analyses were performed. Non-manipulated rats were used as basal parameters.
  
  
  RESULTS
  Our data show that the exposure to high dose of FA during pregnancy predisposes the development of neutrophilic lung inflammation in the offspring, as observed by the profile of cells and cytokines in the lung.
  
  
  CONCLUSIONS
  This study contributes to the understanding of effects of pollution on the development of lung diseases.
authors.affiliation: Department of Pharmacology, University of São Paulo, São Paulo, Brazil.
authors.forename: Marília
authors.initials: M
authors.lastname: Maiellaro
authors.affiliation: Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Rua Vergueiro, 239/245, São Paulo, CEP 01504-000, Brazil.
authors.forename: Rodrigo Silva
authors.initials: RS
authors.lastname: Macedo
authors.affiliation: Department of Pharmacology, University of São Paulo, São Paulo, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mendes
authors.affiliation: Department of Pharmacology, University of São Paulo, São Paulo, Brazil.
authors.forename: Wothan
authors.initials: W
authors.lastname: Tavares-de-Lima
authors.affiliation: Department of Pharmacology, University of São Paulo, São Paulo, Brazil.
authors.forename: Caroline Marcantonio
authors.initials: CM
authors.lastname: Ferreira
authors.affiliation: Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Rua Vergueiro, 239/245, São Paulo, CEP 01504-000, Brazil. alsantosfranco@gmail.com.
authors.forename: Adriana
authors.initials: A
authors.lastname: Lino-dos-Santos-Franco
mesh_terms: D000534:Alum Compounds; D000818:Animals; D001249:Asthma / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D008168:Lung / Q000187:drug effects* / Q000276:immunology; D008431:Maternal-Fetal Exchange; D009504:Neutrophils / Q000187:drug effects*; D010047:Ovalbumin; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017208:Rats, Wistar
chemical_list: D000534:Alum Compounds; C446402:ovalbumin-alum; D005557:Formaldehyde; D010047:Ovalbumin
keywords: Eosinophil influx; Formaldehyde inhalation; Neutrophil influx