title: Preparation and in vitro evaluation of enteric-coated tablets of rosiglitazone sodium.
abstract: The aim of this study was to prepare the rosiglitazone sodium enteric-coated tablets and investigate its release rate. The rosiglitazone sodium enteric-coated tablet was prepared by single punch tablet press using substituted hydroxypropyl cellulose and polyvinylpyrrolidone (PVP). The release rate from the enteric-coated tablet of rosiglitazone sodium was evaluated. The release rate study showed that few rosiglitazone sodium was released from enteric coated formulation within 2 h in simulated gastric juice, while it released more than 80% of the labeled amount in 30 min in simulated intestinal juice. The preparing method of rosiglitazone sodium enteric-coated tablets was simple and had a good reproducibility. The release condition and determined methods could be used for the routine determinations of rosiglitazone sodium enteric-coated tablets.
authors.affiliation: School of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Xin-Mei
authors.initials: XM
authors.lastname: Pan
authors.affiliation: School of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Run
authors.initials: R
authors.lastname: Gan
authors.affiliation: School of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Xiang-Nan
authors.initials: XN
authors.lastname: Hu
keywords: Enteric-coated tablet; Hydroxypropyl cellulose; Polyvinylpyrrolidone (PVP); Release tests