title: Alcohol consumption and risk of myelodysplastic syndromes: a case-control study.
abstract: OBJECTIVE
  Epidemiological studies on alcohol consumption and the risk of myelodysplastic syndromes (MDS) have been inconclusive. We evaluated the association between alcohol consumption and MDS risk in a Chinese population.
  
  
  METHODS
  A hospital-based case-control study was conducted between 2012 and 2013 in Hangzhou, China. The analysis included 208 case-control pairs. Diagnosis of MDS was confirmed according to the 2008 World Health Organization classification system. Controls were individually matched to the cases by gender, birth quinquennium, and residential locality. Information on habitual alcohol consumption, diet, and lifestyle was sought from face-to-face interview using a validated questionnaire. Odds ratios (ORs) were calculated using conditional logistic regression.
  
  
  RESULTS
  Fewer cases (36.5 %) were classified as alcohol drinkers compared with the controls (48.6 %). Compared with abstainers, the adjusted OR for alcohol drinkers was 0.41 (95 % CI 0.21-0.80), and significant reduced risks were found for light alcohol consumption (≤12.5 g/day of ethanol) and for wine consumption, adjusted ORs (95 % CIs) being 0.27 (0.12-0.61) and 0.12 (0.02-0.79), respectively. Compared with individuals who consumed neither alcohol nor cigarettes, the reduced risk associated with light alcohol consumption was only statistically significant among non-smokers (OR 0.19, 95 % CI 0.06-0.60).
  
  
  CONCLUSIONS
  The findings suggest a favorable role of light alcohol consumption in MDS, particularly among non-smokers.
authors.affiliation: School of Population Health, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA, 6009, Australia.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: School of Population Health, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA, 6009, Australia.
authors.forename: C D'Arcy J
authors.initials: CD
authors.lastname: Holman
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, The People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
authors.affiliation: School of Population Health, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA, 6009, Australia. min.zhang@mq.edu.au.|Center for Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Road, Sydney, NSW, 2109, Australia. min.zhang@mq.edu.au.
authors.forename: Min
authors.identifier: http://orcid.org/0000-0003-0167-0404
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064829:Alcohol Abstinence / Q000706:statistics & numerical data*; D000428:Alcohol Drinking / Q000453:epidemiology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000453:epidemiology*; D016017:Odds Ratio; D065840:Protective Factors; D040242:Risk Reduction Behavior; D012907:Smoking / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Alcohol consumption; Case–control study; Myelodysplastic syndromes