title: Epicutaneous immunotherapy for food allergy as a novel pathway for oral tolerance induction.
abstract: Epicutaneous immunotherapy is a developing technique, aiming at desensitizing patients with food allergy with less risks that oral ingestion or injection could generate. Several clinical trials have been performed and are currently running, in milk and peanut allergy, assessing the safety of the technique and its efficacy. Preclinical models indicate a major role in the mechanisms of desensitization, for example, Tregs and epigenetic modifications.
authors.affiliation: DBV Technologies, Green Square, 80/84 rue des Meuniers, Bagneux, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Mondoulet
authors.affiliation: DBV Technologies, Green Square, 80/84 rue des Meuniers, Bagneux, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Dioszeghy
authors.affiliation: DBV Technologies, Green Square, 80/84 rue des Meuniers, Bagneux, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Thébault
authors.affiliation: DBV Technologies, Green Square, 80/84 rue des Meuniers, Bagneux, France.
authors.forename: Pierre-Henri
authors.initials: PH
authors.lastname: Benhamou
authors.affiliation: Université Paris Descartes - Hôpital Necker-Enfants Malades, 149 Rue de Sèvres, 75015 Paris, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Dupont
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003888:Desensitization, Immunologic / Q000295:instrumentation / Q000379:methods*; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D006801:Humans; D007223:Infant; D051379:Mice; D016269:Milk Hypersensitivity / Q000628:therapy*; D021183:Peanut Hypersensitivity / Q000628:therapy*; D012867:Skin / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D035703:Therapies, Investigational / Q000295:instrumentation / Q000379:methods*; D057968:Transdermal Patch
keywords: adults; animal models; children; epicutaneous immunotherapy; food allergy; regulatory T cells; skin