title: Functional properties of chitosan built nanohydrogel with enhanced glucose-sensitivity.
abstract: A new approach to design multifunctional chitosan based nanohydrogel with enhanced glucose sensitivity, stability, drug loading and release profile are reported. Two approaches were followed for functionalization of chitosan based nanohydrogel with 3-APBA via EDC and 3-APTES. The effective functionalization, structure and morphology of Chitosan based IPN respectively were confirmed by FTIR, SEM and AFM. At physiological conditions, the glucose-induced volume phase transition and release profile of the model drug Alizarin Red with 1,2-diol structure (comparative to insulin as a drug as well as a dye for bio separation) were studied at various glucose concentrations, pH and ionic strengths. The results suggested a new concept for diabetes treatment and diols sensitivity in view of their potential hi-tech applications in self-regulated on-off response to the treatment (drug delivery and bio separation concurrently).
authors.affiliation: School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300 Nibong Tebal, Pulau Pinang, Malaysia.
authors.forename: Faheem
authors.initials: F
authors.lastname: Ullah
authors.affiliation: School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300 Nibong Tebal, Pulau Pinang, Malaysia.
authors.forename: Muhammad Bisyrul Hafi
authors.initials: MB
authors.lastname: Othman
authors.affiliation: School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300 Nibong Tebal, Pulau Pinang, Malaysia.
authors.forename: Fatima
authors.initials: F
authors.lastname: Javed
authors.affiliation: School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300 Nibong Tebal, Pulau Pinang, Malaysia.
authors.forename: Zulkifli
authors.initials: Z
authors.lastname: Ahmad
authors.affiliation: School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300 Nibong Tebal, Pulau Pinang, Malaysia. Electronic address: hazizan@usm.my.
authors.forename: Hazizan Md
authors.initials: HM
authors.lastname: Akil
authors.affiliation: School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, Seri Ampangan, 14300 Nibong Tebal, Pulau Pinang, Malaysia.
authors.forename: Siti Zalifah Md
authors.initials: SZ
authors.lastname: Rasib
mesh_terms: D000880:Anthraquinones / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D065546:Drug Liberation; D005947:Glucose / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures / Q000737:chemistry*; D009994:Osmolar Concentration; D011437:Propylamines; D012821:Silanes / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000880:Anthraquinones; D004337:Drug Carriers; D020100:Hydrogels; D011437:Propylamines; D012821:Silanes; C010078:alizarin; D048271:Chitosan; D005947:Glucose; C477625:amino-propyl-triethoxysilane
keywords: Drug release profile; Glucose sensitivity; Nanohydrogel; Zeta potential; pH