title: The Changes in Mean Platelet Volume after Using of Antiplatelet Drugs in Acute Ischemic Stroke: A Randomized Controlled Trial.
abstract: OBJECTIVE
  To measure the changes of mean platelet volume (MPV) after using four antiplatelet drugs in acute non-cardioembolic ischemic stroke patients and assess the association of antiplatelets and MPV and stroke outcome.
  
  
  METHODS
  Ischemic stroke survivors with National Institute of Health Stroke Scale (NIHSS) 8 were randomly allocated intofour groups, receiving aspirin, clopidogrel, combined aspirin and dipyridamole, and cilostazol. The change of MPV NIHSS, and modified Rankin Scale (mRS) were recorded at baseline and week 4 in all studied groups. MPV was measured using the standard automated blood test for complete blood count.
  
  
  RESULTS
  Twenty-one subjects were included in this study. They comprised of five cases in each antiplatelet group, except for aspirin, which had six subjects. Male was 57%, and hypertension was the most common risk factor (61.9%). Most of participants (76%) had small vessel disease. At 4-week, MPVwas reduced and NIHSS, mRS were improved in every studied group. Clopidogrel sign ficantly reduced NIHSS score (p = 0.003), and it produced the greatest reduction in MPV compared to others.
  
  
  CONCLUSIONS
  Every type of antiplatelets included in this study reduced MPV NIHSS, and mRS in acute non-cardioembolic stroke patients. Clopidogrel improved NIHSS the most.
authors.forename: Rojanant
authors.initials: R
authors.lastname: Haungsaithong
authors.forename: Chesda
authors.initials: C
authors.lastname: Udommongkol
authors.forename: Samart
authors.initials: S
authors.lastname: Nidhinandana
authors.forename: Parnsiri
authors.initials: P
authors.lastname: Chairungsaris
authors.forename: Yotin
authors.initials: Y
authors.lastname: Chinvarun
authors.forename: Jithanorm
authors.initials: J
authors.lastname: Suwantamee
authors.forename: Pasiri
authors.initials: P
authors.lastname: Sithinamsuwan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy*; D013785:Thailand
chemical_list: D010975:Platelet Aggregation Inhibitors