title: Dexmedetomidine-related polyuria in a pediatric patient.
abstract: Polyuria related to pharmacologic α2-adrenoreceptor agonism has been well described in vitro and in animal models and is thought to be the result of functional antagonism of arginine vasopressin. Despite its widespread use as a sedative and anesthetic adjunct, very few reports of dexmedetomidine-related polyuria in humans exist in the literature. We present the first description of a pediatric patient manifesting polyuria and hypernatremia in association with dexmedetomidine infusion for posterior spinal fusion.
authors.affiliation: Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Pittsburgh, PA, 15224, USA. adamsp@upmc.edu.
authors.forename: Phillip S
authors.initials: PS
authors.lastname: Adams
authors.affiliation: Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Pittsburgh, PA, 15224, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cassara
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000037:antagonists & inhibitors; D002648:Child; D020927:Dexmedetomidine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006955:Hypernatremia / Q000139:chemically induced; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D011141:Polyuria / Q000139:chemically induced*; D013123:Spinal Fusion
chemical_list: D006993:Hypnotics and Sedatives; D001127:Arginine Vasopressin; D020927:Dexmedetomidine
keywords: Dexmedetomidine; Pediatric; Polyuria