title: Overrepresentation of Th1- and Th17-like Follicular Helper T Cells in Coronary Artery Disease.
abstract: T cells and B cells play substantial roles in the process of coronary artery disease (CAD). Here, we examined the role of circulating follicular helper T (Tfh) cells in CAD. Compared to non-CAD controls, CAD patients had increased levels of circulating Tfh. Also, circulating Tfh in CAD patients exhibited increased frequencies of Th1- and Th17-like phenotypes and aberrant cytokine expressions. Coculture experiments with B cells showed that Tfh from CAD patients were more potent at inducing antibody production from B cells, enhancing plasmablast differentiation and suppressing B10 cell differentiation. Importantly, we found that the skewing of circulating Tfh toward the Th1/Th17-like cells was directly correlated with B cell inflammation and low density lipoprotein level in CAD patients. Together, our data demonstrated a skewing of blood Tfh composition in CAD patients, which resulted in significant changes in B cell inflammation.
authors.affiliation: Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Ding
authors.affiliation: Department of Orthopedics, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
authors.forename: Wenwu
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: He
authors.affiliation: Ganbu Ward, No. 401 Hospital of PLA, Qingdao, Shandong, China.
authors.forename: Haibing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Research Center, BGC Biotechnology, Chicago, IL, USA.
authors.forename: Colin D
authors.initials: CD
authors.lastname: Conrad
authors.affiliation: Research Center, BGC Biotechnology, Chicago, IL, USA.
authors.forename: Charles M
authors.initials: CM
authors.lastname: Dinney
authors.affiliation: Research Center, BGC Biotechnology, Chicago, IL, USA.
authors.forename: Xiaozou
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.affiliation: Department of Cardiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. malanseh@hotmail.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. zongguiwu@126.com.
authors.forename: Zonggui
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. chunliangcz@126.com.
authors.forename: Chun
authors.initials: C
authors.lastname: Liang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000276:immunology / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: B cell; Coronary artery disease; Follicular helper T cells; Inflammation