title: Innate Immune Factors in Mothers' Breast Milk and Their Lack of Association With Rotavirus Vaccine Immunogenicity in Nicaraguan Infants.
abstract: To better understand underlying causes of lower rotavirus vaccine effectiveness in low-middle income countries (LMICs), we measured innate antiviral factors in Nicaraguan mothers' milk and immune response to the first dose of the pentavalent rotavirus vaccine in corresponding infants. No relationship was found between concentrations of innate factors and rotavirus vaccine response.
authors.affiliation: Department of Family Medicine, School of Medicine.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Becker-Dreps
authors.affiliation: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill.
authors.forename: Wan Suk
authors.initials: WS
authors.lastname: Choi
authors.affiliation: Department of Pediatrics, Human Vaccine Institute, Duke University, Durham, North Carolina.
authors.forename: Lisa
authors.initials: L
authors.lastname: Stamper
authors.affiliation: Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León.
authors.forename: Samuel
authors.initials: S
authors.lastname: Vilchez
authors.affiliation: Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Velasquez
authors.affiliation: Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Sung-Sil
authors.initials: SS
authors.lastname: Moon
authors.affiliation: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Hudgens
authors.affiliation: Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Baoming
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Pediatrics, Human Vaccine Institute, Duke University, Durham, North Carolina.
authors.forename: Sallie R
authors.initials: SR
authors.lastname: Permar
mesh_terms: D003906:Developing Countries; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D000071497:Immunogenicity, Vaccine / Q000276:immunology; D007223:Infant; D008297:Male; D008895:Milk, Human / Q000276:immunology*; D009527:Nicaragua; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000276:immunology*; D016896:Treatment Outcome; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C426945:Pentavac; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined
keywords: Nicaragua; breast milk; innate immunity; lactadherin; lactoferrin; rotavirus vaccines