title: IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases.
abstract: Autoimmune bullous diseases (AIBDs) are characterized by autoantibodies against structural proteins of the dermal-epidermal junction (in pemphigoid diseases) and the epidermal/ epithelial desmosomes (in pemphigus diseases). By far, the most common AIBD is bullous pemphigoid, which is immunopathologically characterized by autoantibodies against BP180 (type XVII collagen) and BP230. IgG and, to a lesser extent, IgA autoantibodies are the major autoantibody isotypes in these disorders. IgE autoantibodies are increasingly reported in particular in bullous pemphigoid. The development of specific and sensitive anti-BP180 IgE ELISA systems, the report of two experimental murine models employing IgE autoantibodies against BP180, and the successful treatment of bullous pemphigoid with the anti-IgE antibody omalizumab have raised interest in the role of IgE autoantibodies and the modulation of their production in AIBDs. Here, the relevance of IgE autoantibodies in the diagnosis, pathophysiology, and treatment decisions of AIBDs, with a focus on bullous pemphigoid, is reviewed.
authors.affiliation: a Department of Dermatology , University of Lübeck , Lübeck , Germany.
authors.forename: Nina
authors.initials: N
authors.lastname: van Beek
authors.affiliation: b Lübeck Institute of Experimental Dermatology (LIED) , University of Lübeck , Lübeck , Germany.
authors.forename: Franziska S
authors.initials: FS
authors.lastname: Schulze
authors.affiliation: a Department of Dermatology , University of Lübeck , Lübeck , Germany.
authors.forename: Detlef
authors.initials: D
authors.lastname: Zillikens
authors.affiliation: a Department of Dermatology , University of Lübeck , Lübeck , Germany.|b Lübeck Institute of Experimental Dermatology (LIED) , University of Lübeck , Lübeck , Germany.
authors.forename: Enno
authors.initials: E
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism*; D015551:Autoimmunity; D003896:Desmosomes / Q000378:metabolism*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D024041:Non-Fibrillar Collagens / Q000276:immunology / Q000378:metabolism*; D010391:Pemphigoid, Bullous / Q000175:diagnosis / Q000276:immunology*; D000097805:Collagen Type XVII
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007073:Immunoglobulin E; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII
keywords: BP180; BP230; Bullous pemphigoid; ELISA; eosinophilia; immunofluorescence microscopy