title: KAHA Ligation at Serine.
abstract: Oxazetidine assisted KAHA ligation was developed by the Bode group as an efficient peptide segment ligation strategy at native serine residues. This milestone achievement should enable the chemical synthesis of difficult-to-prepare proteins for biological studies.
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei, Anhui, 230009, China. ymli@hfut.edu.cn.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Li
authors.affiliation: Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Yi-Chao
authors.initials: YC
authors.lastname: Huang
authors.affiliation: Tsinghua-Peking Center for Life Sciences, Department of Chemistry, Tsinghua University, Beijing, 100084, China. lliu@mail.tsinghua.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D019811:Hydroxylamine / Q000737:chemistry*; D007651:Keto Acids / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011506:Proteins / Q000138:chemical synthesis* / Q000737:chemistry; D012694:Serine / Q000737:chemistry*
chemical_list: D007651:Keto Acids; D011506:Proteins; D019811:Hydroxylamine; D012694:Serine
keywords: KAHA ligation; chemical protein synthesis; ligation reactions; proteins; synthetic methods