title: Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development.
abstract: Primary tumor-associated hypoxia stimulates the production of secreted factors that mobilize bone marrow-derived cells, including immunomodulatory myeloid-derived suppressor cells (MDSCs) to pre-metastatic niches. We recently found that the hypoxia-induced enzyme carbonic anhydrase IX (CAIX) promotes metastasis by stimulating the G-CSF dependent mobilization of granulocytic MDSCs to the lung pre-metastatic niche.
authors.affiliation: Department of Integrative Oncology; BC Cancer Research Centre ; Vancouver, BC, Canada.
authors.forename: Shawn C
authors.initials: SC
authors.lastname: Chafe
authors.affiliation: Department of Integrative Oncology; BC Cancer Research Centre ; Vancouver, BC, Canada ; Department of Biochemistry and Molecular Biology; University of British Columbia ; Vancouver, BC, Canada.
authors.forename: Shoukat
authors.initials: S
authors.lastname: Dedhar
keywords: G-CSF; MDSC; breast cancer; carbonic anhydrase IX; hypoxia; metastasis; pre-metastatic niche