title: Natural product derived insecticides: discovery and development of spinetoram.
abstract: This review highlights the importance of natural product research and industrial microbiology for product development in the agricultural industry, based on examples from Dow AgroSciences. It provides an overview of the discovery and development of spinetoram, a semisynthetic insecticide derived by a combination of a genetic block in a specific O-methylation of the rhamnose moiety of spinosad coupled with neural network-based QSAR and synthetic chemistry. It also emphasizes the key role that new technologies and multidisciplinary approaches play in the development of current spinetoram production strains.
authors.affiliation: Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN, 46268, USA. uggalm@dow.com.
authors.forename: Ute
authors.initials: U
authors.lastname: Galm
authors.affiliation: Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN, 46268, USA.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Sparks
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D004338:Drug Combinations; D005285:Fermentation; D006801:Humans; D007218:Industrial Microbiology; D007306:Insecticides / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship; D012210:Rhamnose / Q000378:metabolism; D016930:Saccharopolyspora / Q000737:chemistry / Q000378:metabolism
chemical_list: D001688:Biological Products; D004338:Drug Combinations; D007306:Insecticides; D018942:Macrolides; D012210:Rhamnose; C415329:spinosad; C548262:spinetoram
keywords: Insecticide; Natural products; Saccharopolyspora spinosa; Spinetoram; Spinosyn