title: [Survey on the status of health effects and relationship between indices of health effects of population in environment cadmium polluted area in Hezhang County, Guizhou Province].
abstract: OBJECTIVE
  To investigate health status of general population in environment cadmium polluted area in Hezhang County, Guizhou Province. Methods The subjects were selected by random sampling from the local resident. The urine samples were collected and detected for cadmium, N-acetyl-β-D-glucosaminidase (NAG) and β2-microglobulin (β2-MG). ICP-MS (inductively coupled plasma-mass spectrometry) was used to determine Cd concentrations. β2-MG was determined using radioimmunoassay. NAG and creatinine was measured by spectrophotometry.
  
  
  RESULTS
  Urinary screening was carried out and 1351 urine samples were collected, 948 samples from polluted area and 403 samples from control area. There were significant difference for urine Cd between polluted and control population. The mean value of urinary Cd in polluted area and control area were 8. 79 µg/g Cr and 2. 93 µg/g Cr respectively, There was significant difference for Cd between pollution and control population(P <0. 05). The positive ratio of urinary Cd in polluted area and control area were 10. 8% and 1. 2% respectively. There were no significant difference for β2-MG and NAG between pollution and control population. The cooperation positive rate of population in polluted and control area were 1. 6% and 0. 5% respectively.
  
  
  CONCLUSIONS
  There were potential health risk in the environmental cadmium polluted area, Cd, β2-MG and NAG should be used together to assess the health risk of environmental cadmium pollution comnletely.
authors.forename: Wenli
authors.initials: W
authors.lastname: Zhang
authors.forename: Dancheng
authors.initials: D
authors.lastname: Yao
authors.forename: Jialong
authors.initials: J
authors.lastname: Sun
authors.forename: Jingxiu
authors.initials: J
authors.lastname: Han
authors.forename: Qi
authors.initials: Q
authors.lastname: Shang
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002104:Cadmium / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000652:urine*; D003404:Creatinine / Q000652:urine; D004781:Environmental Exposure / Q000009:adverse effects; D004784:Environmental Monitoring / Q000379:methods; D004787:Environmental Pollution / Q000009:adverse effects*; D005260:Female; D015386:Hazardous Substances; D006304:Health Status; D006801:Humans; D012306:Risk; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D015386:Hazardous Substances; D002104:Cadmium; D003404:Creatinine; D000118:Acetylglucosaminidase