title: Inhibitory effects of Cymodocea nodosa sulphated polysaccharide on α-amylase activity, liver-kidney toxicities and lipid profile disorders in diabetic rats.
abstract: This study aimed to evaluate for the first time the effects of Cymodocea nodosa sulphated polysaccharide (CNSP) on the α-amylase activity, hyperglycaemia, liver-kidney functions, and pancreatic architecture of alloxan-induced diabetic rats. Animals were allocated into four groups of seven rats each, the body weight and blood glucose levels were estimated periodically for 2 months of treatment by gastric gavages route. The CNSP effect was confirmed by biochemical procedures and histological study. The inhibition of α-amylase activity and protection of pancreatic β-cells induced a decrease in the blood glucose levels and regulated the lipid profile in the plasma of the treated diabetic rats, which helped to maintain the homeostasis of blood lipid. Moreover, CNSP administration induced a significant decrease in the levels of lipid peroxidation in the pancreas, liver and kidney of diabetic rats and protects their functions attested by a decrease in the levels of toxicity parameters in blood.
authors.affiliation: a Laboratory of Plant Biotechnology , Faculty of Sciences of Sfax , Sfax , Tunisia .|d Laboratory of Animal Ecophysiology , Faculty of Sciences of Sfax , Tunisia.
authors.forename: Rihab
authors.initials: R
authors.lastname: Ben Abdallah Kolsi
authors.affiliation: a Laboratory of Plant Biotechnology , Faculty of Sciences of Sfax , Sfax , Tunisia .
authors.forename: Amel
authors.initials: A
authors.lastname: Ben Gara
authors.affiliation: b Histology, Orthopaedic and Traumatology Laboratory Sfax Faculty of Medicine Sfax , Tunisia .
authors.forename: Neila
authors.initials: N
authors.lastname: Jardak
authors.affiliation: c Biochemistry Laboratory, CHU Hedi Chaker , Sfax , Tunisia , and.
authors.forename: Rim
authors.initials: R
authors.lastname: Chaaben
authors.affiliation: d Laboratory of Animal Ecophysiology , Faculty of Sciences of Sfax , Tunisia.
authors.forename: Abdelfattah
authors.initials: A
authors.lastname: El Feki
authors.affiliation: a Laboratory of Plant Biotechnology , Faculty of Sciences of Sfax , Sfax , Tunisia .
authors.forename: Lotfi
authors.initials: L
authors.lastname: El Feki
authors.affiliation: a Laboratory of Plant Biotechnology , Faculty of Sciences of Sfax , Sfax , Tunisia .
authors.forename: Karima
authors.initials: K
authors.lastname: Belghith
mesh_terms: D035961:Alismatales / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013439:Sulfhydryl Reagents / Q000737:chemistry; D000516:alpha-Amylases / Q000037:antagonists & inhibitors* / Q000187:drug effects / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides; D013439:Sulfhydryl Reagents; D000516:alpha-Amylases
keywords: Diabetes; liver-kidney functions; pancreas; polysaccharide; α-amylase