title: Chronic Kidney Disease and Functional Outcomes 6 Months after Ischemic Stroke: A Prospective Multicenter Study.
abstract: BACKGROUND
  The aim of this study was to investigate whether chronic kidney disease (CKD) predicts the outcome of the Functional Independence Measure (FIM) and the Korean version of the modified Barthel Index (K-MBI) 6 months after stroke with adjustment for age, gender, education, smoking, drinking, obesity, hypertension, diabetes mellitus, dyslipidemia, the FIM or K-MBI at discharge and the National Institutes of Health Stroke Scale (NIHSS) score 7 days post stroke.
  
  
  METHODS
  This study is an interim report of the Korean Stroke Cohort for Functioning and Rehabilitation. The sample included 2,037 ischemic stroke patients aged 18 years or older. The FIM and K-MBI scores were assessed at discharge and at 6 months after the onset of stroke. The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. CKD was defined as an eGFR <60 ml/min/1.73 m2.
  
  
  RESULTS
  Overall, the mean age was 65.5 (±12.4) years. The proportion of men was 62.6%. The proportion of CKD cases was 12.7%. The means of the 6-month FIM and K-MBI were 109.8 (±27.9) and 87.0 (±26.4), respectively. In multiple linear regressions, the 6-month FIM after stroke was significantly associated with CKD (-2.85, p < 0.05), age (-0.29, p < 0.01), the FIM at discharge (0.46, p < 0.01) and the 7-day NIHSS score (-1.71, p < 0.01). Additionally, the post-stroke 6-month K-MBI was significantly associated with CKD (-2.88, p < 0.01), age (-0.27, p < 0.01), the K-MBI at discharge (0.46, p < 0.01) and the 7-day NIHSS score (-1.55, p < 0.01).
  
  
  CONCLUSIONS
  This nationwide hospital-based cohort study showed that CKD might predict poor 6-month FIM and K-MBI scores in ischemic stroke patients.
authors.affiliation: Heart Vascular Stroke Imaging Center, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Shin Yi
authors.initials: SY
authors.lastname: Jang
authors.forename: Min Kyun
authors.initials: MK
authors.lastname: Sohn
authors.forename: Jongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Deog Young
authors.initials: DY
authors.lastname: Kim
authors.forename: Sam-Gyu
authors.initials: SG
authors.lastname: Lee
authors.forename: Yong-Il
authors.initials: YI
authors.lastname: Shin
authors.forename: Gyung-Jae
authors.initials: GJ
authors.lastname: Oh
authors.forename: Yang-Soo
authors.initials: YS
authors.lastname: Lee
authors.forename: Min Cheol
authors.initials: MC
authors.lastname: Joo
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Han
authors.forename: Won Hyuk
authors.initials: WH
authors.lastname: Chang
authors.forename: Ahee
authors.initials: A
authors.lastname: Lee
authors.forename: Jeong Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology*; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012737:Sex Factors; D012907:Smoking; D020521:Stroke / Q000150:complications; D000071939:Stroke Rehabilitation; D016896:Treatment Outcome; D055815:Young Adult