title: Chrononutrition.
abstract: Well-regulated eating habits are said to be important for health. A major breakthrough was the discovery of the negative regulatory feedback for transcription via the binding of Clock/Bmal1 to E-box, which forms the basis of biological clocks. Well-regulated eating habits normalize the liver clock gene, the rhythm of CYP7A1 gene, and blood cholesterol levels through insulin secretion. Moreover, well-regulated eating habits actively contribute to better lipid metabolism such as obesity, even if animals ingest a high-fat diet. From reported results so far, chrononutition has two important functions: 1) meal timing is important for our health, and 2) meal timing entrains our body clock.
authors.affiliation: Laboratory of Nutritional Biochemistry, Nagoya University.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Oda
mesh_terms: D000818:Animals; D056926:CLOCK Proteins / Q000235:genetics / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics / Q000378:metabolism; D002909:Chronobiology Phenomena; D057906:Circadian Clocks / Q000502:physiology; D004032:Diet; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D005247:Feeding Behavior; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D062407:Meals; D009765:Obesity / Q000209:etiology / Q000378:metabolism; D013997:Time Factors
chemical_list: D007328:Insulin; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase; D056926:CLOCK Proteins