title: Can Laparoscopic Cholecystectomy Prevent Recurrent Idiopathic Acute Pancreatitis?: A Prospective Randomized Multicenter Trial.
abstract: OBJECTIVE
  The aim of the present trial was to ascertain whether laparoscopic cholecystectomy (LCC) can prevent recurrent attacks of idiopathic acute pancreatitis (IAP).
  
  
  CONCLUSIONS
  Up to 50% to 75% of IAP may be due to microlithiasis, which is undetectable by conventional imaging methods.
  
  
  METHODS
  This randomized, prospective trial included 85 patients (39 in the LCC and 46 in the control group) in 8 hospitals in Finland. We included adult patients (over 18 years) with their first attack of IAP. The diagnosis of IAP was based on the exclusion of common etiological reasons for acute pancreatitis (AP), whereafter the patients were randomized into conservative watchful waiting (controls) or LCC group. The primary end point was the number of patients with recurrent AP during the follow-up. All recurrent attacks of AP after an initial IAP episode were registered.
  
  
  RESULTS
  During a median follow-up of 36 (5-58) months, the recurrence of IAP was significantly higher in the control group than in LCC group (14/46 vs. 4/39, P = 0.016), as was also the number of recurrences (23/46 vs. 8/39, P = 0.003). In the subgroup of patients with at least 24 months' follow-up, the recurrence was still higher among controls (14/37 vs. 4/35, P = 0.008). In patients with normal liver function, recurrence was also significantly higher in the control than in the LCC group (13/46 vs. 4/39, P = 0.026). During surgery, 23/39 (59%) of the gallbladders were found to contain biliary stones or sludge.
  
  
  CONCLUSIONS
  LCC can effectively prevent the recurrence of IAP when all other possible etiologies of pancreatitis are carefully excluded. A total of 5 patients needed to be treated (NNT-value) to prevent 1 IAP.
authors.affiliation: *Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland †Department of Surgery, Kuopio University Hospital, Kuopio, Finland ‡Department of Surgery, Vaasa Central Hospital, Vaasa, Finland §Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland ¶Department of Surgery, Seinäjoki Central Hospital, Seinäjoki, Finland ||Department of Surgery, Kanta-Häme Central Hospital, Hämeenlinna, Finland **Department of Surgery, Kuopio University Hospital and University of Eastern Finland.
authors.forename: Sari
authors.initials: S
authors.lastname: Räty
authors.forename: Jukka
authors.initials: J
authors.lastname: Pulkkinen
authors.forename: Isto
authors.initials: I
authors.lastname: Nordback
authors.forename: Juhani
authors.initials: J
authors.lastname: Sand
authors.forename: Mikael
authors.initials: M
authors.lastname: Victorzon
authors.forename: Juha
authors.initials: J
authors.lastname: Grönroos
authors.forename: Heli
authors.initials: H
authors.lastname: Helminen
authors.forename: Pekka
authors.initials: P
authors.lastname: Kuusanmäki
authors.forename: Pia
authors.initials: P
authors.lastname: Nordström
authors.forename: Hannu
authors.initials: H
authors.lastname: Paajanen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D042882:Gallstones / Q000150:complications / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult