title: Predictive timing functions of cortical beta oscillations are impaired in Parkinson's disease and influenced by L-DOPA and deep brain stimulation of the subthalamic nucleus.
abstract: Cortex-basal ganglia circuits participate in motor timing and temporal perception, and are important for the dynamic configuration of sensorimotor networks in response to exogenous demands. In Parkinson's disease (PD) patients, rhythmic auditory stimulation (RAS) induces motor performance benefits. Hitherto, little is known concerning contributions of the basal ganglia to sensory facilitation and cortical responses to RAS in PD. Therefore, we conducted an EEG study in 12 PD patients before and after surgery for subthalamic nucleus deep brain stimulation (STN-DBS) and in 12 age-matched controls. Here we investigated the effects of levodopa and STN-DBS on resting-state EEG and on the cortical-response profile to slow and fast RAS in a passive-listening paradigm focusing on beta-band oscillations, which are important for auditory-motor coupling. The beta-modulation profile to RAS in healthy participants was characterized by local peaks preceding and following auditory stimuli. In PD patients RAS failed to induce pre-stimulus beta increases. The absence of pre-stimulus beta-band modulation may contribute to impaired rhythm perception in PD. Moreover, post-stimulus beta-band responses were highly abnormal during fast RAS in PD patients. Treatment with levodopa and STN-DBS reinstated a post-stimulus beta-modulation profile similar to controls, while STN-DBS reduced beta-band power in the resting-state. The treatment-sensitivity of beta oscillations suggests that STN-DBS may specifically improve timekeeping functions of cortical beta oscillations during fast auditory pacing.
authors.affiliation: Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Gulberti
authors.affiliation: Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: C K E
authors.initials: CK
authors.lastname: Moll
authors.affiliation: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hamel
authors.affiliation: Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Buhmann
authors.affiliation: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: J A
authors.initials: JA
authors.lastname: Koeppen
authors.affiliation: Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany ; Department of Neurology, University Hospital of Würzburg, Josef-Schneider-Strasse 11, Würzburg 97080, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Boelmans
authors.affiliation: Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany ; Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Maria-Goeppert-Strasse 1, 23562 Lübeck, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Zittel
authors.affiliation: Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Gerloff
authors.affiliation: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Westphal
authors.affiliation: Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: T R
authors.initials: TR
authors.lastname: Schneider
authors.affiliation: Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
authors.forename: A K
authors.initials: AK
authors.lastname: Engel
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001307:Auditory Perception / Q000502:physiology*; D001611:Beta Rhythm; D002540:Cerebral Cortex / Q000503:physiopathology*; D046690:Deep Brain Stimulation; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000503:physiopathology* / Q000601:surgery; D013997:Time Factors
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa
keywords: Beta oscillations; Deep brain stimulation; Interval timing; Parkinson's disease; Subthalamic nucleus