title: Application of quantitative computed tomography for assessment of trabecular bone mineral density, microarchitecture and mechanical property.
abstract: Osteoporosis is a common metabolic bone disease, causing increased skeletal fragility characterized by a low bone mass and trabecular microarchitectural deterioration. Assessment of the bone mineral density (BMD) is the primary determinant of skeletal fragility. Computed tomography (CT)-based trabecular microarchitectural and mechanical assessments are important methods to evaluate the skeletal strength. In this review, we focus the feasibility of QCT BMD measurement using a calibration phantom or phantomless. The application of QCT could extend the bone mineral density assessment to all patients who underwent a heart, lung, whole-body, and as well as all routine clinical implications of CT scan.
authors.affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA, 1124 West Carson Street, Torrance, CA 90502. Electronic address: smao@labiomed.org.
authors.forename: Song Shou
authors.initials: SS
authors.lastname: Mao
authors.affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA, 1124 West Carson Street, Torrance, CA 90502. Electronic address: dli@labiomed.org.
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA, 1124 West Carson Street, Torrance, CA 90502. Electronic address: yluo@labiomed.org.
authors.forename: Yanting
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA, 1124 West Carson Street, Torrance, CA 90502. Electronic address: ysyed@labiomed.org.
authors.forename: Younus Saleem
authors.initials: YS
authors.lastname: Syed
authors.affiliation: Los Angeles Biomedical Research Institute at Harbor-UCLA, 1124 West Carson Street, Torrance, CA 90502. Electronic address: mbudoff@labiomed.org.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Budoff
mesh_terms: D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D019047:Phantoms, Imaging; D014057:Tomography, X-Ray Computed / Q000592:standards*
keywords: Bone mineral density; Calibration phantom; Multi-row detector CT; Quantitative CT