title: Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases.
abstract: The treatment of brain tumors and neurodegenerative diseases, represents an ongoing challenge. In Central Nervous System (CNS) the achievement of therapeutic concentration of chemical agents is complicated by the presence of distinct set of efflux proteins, such as ATP-Binding Cassette (ABC) transporters localized on the Blood-Brain Barrier (BBB). The activity of ABC transporters seems to be a common mechanism that underlies the poor response of CNS diseases to therapies. The molecular characterization of Breast Cancer Resistance Protein (BCRP/ABCG2), as an ABC transporter conferring multidrug resistance (MDR), has stimulated many studies to investigate its activity on the BBB, its involvement in physiology and CNS diseases and its role in limiting the delivery of drugs in CNS. In this review, we highlight the activity and localization of BCRP on the BBB and the action that this efflux pump has on many conventional drugs or latest generation molecules used for the treatment of CNS tumors and other neurodegenerative diseases.
authors.forename: Anna Lisa
authors.initials: AL
authors.lastname: Iorio
authors.forename: Martina da
authors.initials: Md
authors.lastname: Ros
authors.forename: Ornella
authors.initials: O
authors.lastname: Fantappiè
authors.forename: Maurizio
authors.initials: M
authors.lastname: Lucchesi
authors.forename: Ludovica
authors.initials: L
authors.lastname: Facchini
authors.forename: Alessia
authors.initials: A
authors.lastname: Stival
authors.forename: Sabrina
authors.initials: S
authors.lastname: Becciani
authors.forename: Milena
authors.initials: M
authors.lastname: Guidi
authors.forename: Claudio
authors.initials: C
authors.lastname: Favre
authors.forename: Maurizio de
authors.initials: Md
authors.lastname: Martino
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Genitori
authors.affiliation: Neuro-oncology Unit, Department of Pediatric Medicine, Meyer Children's Hospital. Viale G.Pieraccini 24, 50139 Florence, Italy. iacopo.sardi@meyer.it.
authors.forename: Iacopo
authors.initials: I
authors.lastname: Sardi
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2 / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D001812:Blood-Brain Barrier; D016543:Central Nervous System Neoplasms / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000628:therapy*; D018697:Nootropic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D014018:Tissue Distribution
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D018697:Nootropic Agents