title: Exploring the Electrophysiologic and Hemodynamic Effects of Cardiac Resynchronization Therapy: From Bench to Bedside and Vice Versa.
abstract: Cardiac resynchronization therapy (CRT) is an important therapy for heart failure patients with prolonged QRS duration. In patients with left bundle branch block the altered left ventricular electrical activation results in dyssynchronous, inefficient contraction of the left ventricle. CRT aims to reverse these changes and to improve cardiac function. This article explores the electrophysiologic and hemodynamic changes that occur during CRT in patient and animal studies. It also addresses how novel techniques, such as multipoint and endocardial pacing, can further improve the electromechanical response.
authors.affiliation: Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
authors.forename: Rick
authors.initials: R
authors.lastname: Schreurs
authors.affiliation: Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
authors.forename: Rob F
authors.initials: RF
authors.lastname: Wiegerinck
authors.affiliation: Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands. Electronic address: frits.prinzen@maastrichtuniversity.nl.
authors.forename: Frits W
authors.initials: FW
authors.lastname: Prinzen
mesh_terms: D000818:Animals; D002037:Bundle-Branch Block / Q000150:complications / Q000503:physiopathology* / Q000517:prevention & control; D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D056966:Excitation Contraction Coupling; D006329:Heart Conduction System / Q000503:physiopathology*; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology* / Q000517:prevention & control*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D057170:Translational Research, Biomedical / Q000639:trends; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control
keywords: Animal research; Cardiac resynchronization therapy; Electrophysiology; Hemodynamics; Left bundle branch block