title: Characterizations and Correlations of Wall Shear Stress in Aneurysmal Flow.
abstract: Wall shear stress (WSS) is one of the most studied hemodynamic parameters, used in correlating blood flow to various diseases. The pulsatile nature of blood flow, along with the complex geometries of diseased arteries, produces complicated temporal and spatial WSS patterns. Moreover, WSS is a vector, which further complicates its quantification and interpretation. The goal of this study is to investigate WSS magnitude, angle, and vector changes in space and time in complex blood flow. Abdominal aortic aneurysm (AAA) was chosen as a setting to explore WSS quantification. Patient-specific computational fluid dynamics (CFD) simulations were performed in six AAAs. New WSS parameters are introduced, and the pointwise correlation among these, and more traditional WSS parameters, was explored. WSS magnitude had positive correlation with spatial/temporal gradients of WSS magnitude. This motivated the definition of relative WSS gradients. WSS vectorial gradients were highly correlated with magnitude gradients. A mix WSS spatial gradient and a mix WSS temporal gradient are proposed to equally account for variations in the WSS angle and magnitude in single measures. The important role that WSS plays in regulating near wall transport, and the high correlation among some of the WSS parameters motivates further attention in revisiting the traditional approaches used in WSS characterizations.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Arzani
authors.forename: Shawn C
authors.initials: SC
authors.lastname: Shadden
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology; D006439:Hemodynamics; D008954:Models, Biological; D066230:Patient-Specific Modeling; D033081:Shear Strength; D062211:Spatio-Temporal Analysis; D013314:Stress, Mechanical