title: Effective Electroporation Therapy of Human Pancreatic Tumors Implanted in Nude Mice.
abstract: Electroporation therapy (EPT), also known as electrochemo-therapy (ECT), of a poorly differentiated human pancreatic carcinoma (Panc-3) implanted subcutaneously in nude mice significantly enhanced the cytotoxicity of bleomycin to tumor cells. A single treatment of intratumoral injection of bleomycin followed by 6 × 99 μs square wave electrical pulses of 1370 V resulted in complete tumor regression in 68% and partial regression (>80%) in 20% of the treated mice on day 28 following treatment. No palpable tumor was observed in 64% of the mice even 120 days after treatment. Histological studies of tissue samples taken from tumor sites 120 days after treatment in the D+E+ group showed complete absence of tumor cells.
authors.affiliation: a Genetronics, Inc., San Diego, California, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Dev
authors.affiliation: a Genetronics, Inc., San Diego, California, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Nanda
authors.affiliation: b Anticancer, Inc., San Diego, California, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: An
authors.affiliation: b Anticancer, Inc., San Diego, California, USA.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: b Anticancer, Inc., San Diego, California, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Hoffman
authors.affiliation: a Genetronics, Inc., San Diego, California, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Hofmann
keywords: Bleomycin and Tumor; Electrochemotherapy; Electroporation Therapy; Pancreatic Cancer