title: Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon.
abstract: Congenital melanocytic nevus (CMN) is a neural crest-derived hamartoma, which appear at or soon after birth. CMN has a dynamic course and may show variable changes over time, including spontaneous involution. Spontaneous involution of CMN is a rare phenomenon and is often reported in association with halo phenomenon or vitiligo. The mechanism of halo phenomenon is yet to be investigated but is suggested to be a destruction of melanocytes by immune responses of cytotoxic T cells or IgM autoantibodies. Here, the authors report an interesting case of spontaneously regressed medium-sized CMN with halo phenomenon and without vitiligo, which provides evidence that cytotoxic T cells account for the halo formation and pigmentary regression of CMN.
authors.affiliation: Department of Dermatology, Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
authors.forename: Noo Ri
authors.initials: NR
authors.lastname: Lee
authors.forename: Hee-Chul
authors.initials: HC
authors.lastname: Chung
authors.forename: Hannah
authors.initials: H
authors.lastname: Hong
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Sung Ku
authors.initials: SK
authors.lastname: Ahn
mesh_terms: D005260:Female; D006801:Humans; D009365:Neoplasm Regression, Spontaneous / Q000276:immunology*; D009508:Nevus, Pigmented / Q000151:congenital* / Q000276:immunology*; D012878:Skin Neoplasms / Q000151:congenital* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D055815:Young Adult