title: Invasive cervical cancer in pregnancy.
abstract: Detection of invasive cervical cancer during pregnancy is rare, with reported incidence rates ranging from 0.05% to 0.1%. However, cervical cancer is one of the most common malignancies diagnosed during pregnancy. The management of invasive cervical cancer in pregnancy is extremely challenging and requires a multidisciplinary team approach to optimise the treatment for the patient by simultaneously providing the best chance of survival for the foetus. The approach is based mainly on the following factors: gestational age at the time of the diagnosis, stage, histological subtype, desire regarding fertility and quality of life. The gold standard treatment for this condition in pregnancy is not yet established. This is due to the absence of prospective studies and clinical trials. Therefore, its management presents a dilemma that requires individualisation of care. The various factors that need to be considered for obtaining a good outcome for both mother and child are described in this study.
authors.affiliation: Department of Gynaecological Oncology, Barts Health NHS Trust, Royal London Hospital, London E1 1BB, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: La Russa
authors.affiliation: Department of Gynaecological Oncology, Barts Health NHS Trust, Royal London Hospital, London E1 1BB, United Kingdom. Electronic address: arjun.jeyarajah@bartshealth.nhs.uk.
authors.forename: A R
authors.initials: AR
authors.lastname: Jeyarajah
mesh_terms: D000032:Abortion, Therapeutic; D017024:Chemotherapy, Adjuvant; D003127:Colposcopy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D014626:Vaginal Smears
keywords: cancer in pregnancy; chemotherapy in pregnancy; invasive cervical cancer