title: Elevated inflammatory markers in preeclamptic pregnancies, but no relation to systemic arterial stiffness.
abstract: OBJECTIVE
  To investigate if circulating markers of systemic and vascular inflammation are associated with systemic arterial properties at term and 6months post-partum in women with preeclampsia (PE) and normal pregnancy (NP).
  
  
  METHODS
  Longitudinal, sampling at term and 6months post-partum in 34 women (32±6years) with PE and 61 women (32±5years) with NP.
  
  
  METHODS
  Circulating markers related to systemic and vascular inflammation were measured by enzyme immune-assay. Systemic arterial properties were estimated by Doppler (transthoracic echocardiography) and calibrated right subclavian artery pulse traces.
  
  
  RESULTS
  CXCL16, soluble tumor necrosis factor receptor type 1 (sTNF-R1), monocyte chemoattractant peptide 1, pentraxin 3 and soluble vascular adhesion molecule 1 (sVCAM-1) were elevated at term in PE, and sTNF-R1 remained elevated 6months post partum compared to NP. However, apart from a negative correlation between mean arterial pressure and sTNF-R1 and sVCAM-1 at term, no associations between systemic and vascular inflammatory markers and systemic arterial properties as reflected by characteristic impedance and arterial elastance, representing proximal aortic stiffness and effective arterial elastance, were found at any time point.
  
  
  CONCLUSIONS
  Preeclamptic pregnancies are characterized by increased circulating levels of systemic and vascular inflammatory markers. However, these are not associated with systemic arterial properties at term or 6months post partum.
authors.affiliation: National Resource Center for Women's Health, Oslo University Hospital Rikshospitalet, Oslo, Norway; Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Mette-Elise
authors.initials: ME
authors.lastname: Estensen
authors.affiliation: Department of Anaesthesiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Guro
authors.initials: G
authors.lastname: Grindheim
authors.affiliation: Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute for Surgical Research, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Espen W
authors.initials: EW
authors.lastname: Remme
authors.affiliation: Section of Specialized Endocrinology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Kristin
authors.initials: K
authors.lastname: Godang
authors.affiliation: Department of Obstetrics, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Tore
authors.initials: T
authors.lastname: Henriksen
authors.affiliation: Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway.
authors.forename: Pål
authors.initials: P
authors.lastname: Aukrust
authors.affiliation: Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Svend
authors.initials: S
authors.lastname: Aakhus
authors.affiliation: Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway.
authors.forename: Lars
authors.initials: L
authors.lastname: Gullestad
authors.affiliation: Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway; K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway. Electronic address: thor.ueland@medisin.uio.no.
authors.forename: Thor
authors.initials: T
authors.lastname: Ueland
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000276:immunology; D000075743:Chemokine CXCL16; D018925:Chemokines / Q000097:blood*; D019743:Chemokines, CXC / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008137:Longitudinal Studies; D049590:Postpartum Period / Q000276:immunology; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology*; D011247:Pregnancy; D051116:Receptors, Scavenger / Q000097:blood; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood; D000683:Serum Amyloid P-Component / Q000276:immunology; D013348:Subclavian Artery / Q000000981:diagnostic imaging; D053773:Transforming Growth Factor beta1 / Q000097:blood; D014463:Ultrasonography; D059289:Vascular Stiffness / Q000276:immunology; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D000075743:Chemokine CXCL16; D018925:Chemokines; D019743:Chemokines, CXC; D051116:Receptors, Scavenger; D047888:Receptors, Tumor Necrosis Factor, Type I; D000683:Serum Amyloid P-Component; D053773:Transforming Growth Factor beta1; D000099153:Pentraxins; C423727:CXCL16 protein, human
keywords: Arterial stiffness; Inflammation; Preeclampsia; Pregnancy