title: [Description of Clinical and Neurocognitive Profiles in Offspring of Bipolar-Type-I Parents From a Multimodal Intervention Program: Prisma].
abstract: BACKGROUND
  Offspring of bipolar parents are a high risk population for the develop of mental diseases, their study allow determining the genetic risk, early symptoms, prodromes and psychopathology of bipolar disorder.
  
  
  OBJECTIVE
  To describe the psychopathological characteristics and neurocognitives profiles of the offspring of bipolar type I parents. And to identify the presence of sub-syndromal symptoms in all the symptom domains.
  
  
  METHODS
  A descriptive and cross-sectional study was conducted on 110 offspring between 6 and 30 years old. Semi-structured diagnostic interviews were performed. The intelectual coeficient was determined and a neuropsychological assessment was performed on 89 offspring.
  
  
  RESULTS
  The most prevalent disorder in the offspring was ADHD (27.6%), with major depression (15.5%) and separation anxiety (14.1%) also being prevalent. Seven patients of the sample were diagnosed with bipolar disorder. There was a statistically significant difference between the age groups for ADHD prevalence. The most frequent sub-syndromal symptoms were observed in the disruptive group. Alterations in the cognitive domains: attention, verbal fluency, work memory, and speed of information processing, were observed in the group younger than 18 years.
  
  
  CONCLUSIONS
  The offspring of bipolar parents have an elevated rate of psychopathology and cognitive alterations. They are a high risk population for the development of mental disease. These subjects also require close longitudinal observation and early and preventive therapeuthic interventions.
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia; Programa de Trastornos del Ánimo, Hospital San Vicente Fundación, Medellín, Colombia; Grupo de Investigación en Psiquiatría, Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Electronic address: tdahcartagena@gmail.com.
authors.forename: Juan David
authors.initials: JD
authors.lastname: Palacio-Ortíz
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Esteban
authors.initials: E
authors.lastname: Uribe-Villa
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Paula
authors.initials: P
authors.lastname: Duque-Ríos
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Paola
authors.initials: P
authors.lastname: Gutiérrez-Briceño
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Violeta
authors.initials: V
authors.lastname: Zapata-Henao
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Cristian Esteban
authors.initials: CE
authors.lastname: Peña-Quintero
authors.affiliation: Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia; Programa de Trastornos del Ánimo, Hospital San Vicente Fundación, Medellín, Colombia; Grupo de Investigación en Psiquiatría, Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia; Jefe del Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Jaramillo
mesh_terms: D000293:Adolescent; D000328:Adult; D001010:Anxiety, Separation / Q000453:epidemiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology*; D001714:Bipolar Disorder / Q000453:epidemiology*; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology*; D003072:Cognition Disorders / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D055815:Young Adult
keywords: Bipolar disorder; Bipolar's offspring; Hijos; Hijos de pacientes con trastorno bipolar; Neurocognitives profiles; Neurocognitivos; Offspring; Psicopatología; Psychopathology; Trastorno afectivo bipolar