title: Regulating Factors in Acid-Sensing Ion Channel 1a Function.
abstract: In recent years, research of acid sensing ion channels (ASICs) has increased tremendously, especially studies focusing on ASIC1a, which plays a critical role in many important physiologic and pathological functions. This review will discuss factors regulating ASIC1a expression and activity in various conditions and will provide a theoretical basis for clinical development and application of ASIC1a modifiers.
authors.affiliation: School of Pharmacy, Anhui Medical University, Meishan Road, Hefei, 230032, Anhui, China.
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurobiology, Morehouse School of Medicine, 720 Westview Dr., Atlanta, GA, USA.
authors.forename: Zaven
authors.initials: Z
authors.lastname: O'Bryant
authors.affiliation: School of Pharmacy, Anhui Medical University, Meishan Road, Hefei, 230032, Anhui, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Anhui Medical University, Meishan Road, Hefei, 230032, Anhui, China. aydhy@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
mesh_terms: D062646:Acid Sensing Ion Channel Blockers / Q000494:pharmacology; D062565:Acid Sensing Ion Channels / Q000378:metabolism*; D000818:Animals; D006801:Humans; D010084:Oxidation-Reduction; D015398:Signal Transduction; D062687:Sodium Channel Agonists / Q000494:pharmacology
chemical_list: D062646:Acid Sensing Ion Channel Blockers; D062565:Acid Sensing Ion Channels; D062687:Sodium Channel Agonists
keywords: ASICs; Ion channels; Neuronal injury; Pharmacology; Stroke