title: Flavanones of Erythrina livingstoniana with antioxidant properties.
abstract: Six new flavanones (1-6), together with six known compounds were isolated from Erythrina livingstoniana. Their structures were elucidated on the basis of NMR data and HRMS(n) fragmentation pathway and by comparison with literature data. Compounds 5, 7 and 8 showed remarkable DPPH free radical scavenging efficacies. The compounds, however, did not demonstrate an anti-inflammatory potential when tested using a PGE2 (prostaglandin E2) competitive enzyme immunoassay. The plausible biosynthetic pathways of the isolated compounds are described.
authors.affiliation: Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221, Dortmund, Germany.
authors.forename: Kibrom Gebreheiwot
authors.initials: KG
authors.lastname: Bedane
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221, Dortmund, Germany.
authors.forename: Souvik
authors.initials: S
authors.lastname: Kusari
authors.affiliation: Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana.
authors.forename: Ishmael B
authors.initials: IB
authors.lastname: Masesane
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221, Dortmund, Germany. Electronic address: m.spiteller@infu.tu-dortmund.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Spiteller
authors.affiliation: Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana. Electronic address: majindar@mopipi.ub.bw.
authors.forename: Runner R T
authors.initials: RR
authors.lastname: Majinda
mesh_terms: D015232:Dinoprostone; D004895:Erythrina / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D044950:Flavanones; D016166:Free Radical Scavengers; D010936:Plant Extracts; D015232:Dinoprostone
keywords: Erylivingstone D–I; Erythrina livingstoniana; Fabaceae; Flavanone; HRMS(n); NMR