title: Exposure to the mixture of organophosphorus pesticides is embryotoxic and teratogenic on gestational rats during the sensitive period.
abstract: Mixture of organophosphorus pesticides (MOPs) has been used worldwide to increase food production. The MOPs are harmful, and the exposure to them is both agricultural and nonagricultural through contaminated food. The neurotoxicity of MOPs has received more consideration recently due to the increased cases of malformed fetuses suspected to be caused by the MOPs exposure during gestation; however, relevant studies in animal model are rare. In this study, we performed a comprehensive analysis and demonstrated potential perinatal embryotoxicity and teratogenicity of MOPs exposure. As results, we found that MOPs decreased in utero fetal growth and alter the ratio of organs to whole body weight of the pregnant rats. MOPs also had been shown to disturb the balance of sex hormones and affect the reproduction of rats. Furthermore, we found various significantly elevated deformities in MOPs exposed embryos, confirming the embryotoxic and teratogenic effects of maternal exposure to MOPs. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 139-146, 2017.
authors.affiliation: Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710061, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710061, China.
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710061, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710061, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Liu
authors.affiliation: The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Xue
authors.affiliation: Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710061, China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
authors.forename: Aimin
authors.initials: A
authors.lastname: Yang
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D008297:Male; D018811:Maternal Exposure; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010575:Pesticides / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens / Q000633:toxicity*
chemical_list: D009943:Organophosphorus Compounds; D010575:Pesticides; D013723:Teratogens
keywords: embryotoxicity; endocrine disruption; mixture of organophosphorus pesticides; reproductive toxicity; sensitive period of teratogenesis