title: Association of Fc gamma-receptors IIa, IIIa, and IIIb genetic polymorphism with susceptibility to chronic periodontitis in South Indian population.
abstract: OBJECTIVE
  Fc gamma receptors (FcγRs) are the members of the immunoglobulin superfamily and may play a role in the pathogenesis of periodontitis. Genetic variation in these receptors and its link with various forms of periodontitis is being studied in different populations. The aim of the present study is to determine whether specific FcγRIIa, FcγRIIIa, and FcγRIIIb alleles and/or genotypes are associated with risk for susceptibility to generalized chronic periodontitis (GCP) in South Indian population.
  
  
  METHODS
  The study population consisted of 120 South Indian subjects; 60 with GCP and 60 periodontally healthy. Deoxyribonucleic acid (DNA) was extracted from samples collected by scrapping buccal epithelium. FcγRIIa and FcγRIIIa genotyping were performed by polymerase chain reaction (PCR) amplification of DNA with allele-specific primers followed by allele-specific restriction digestion of the products. However, FcγRIIIb genotyping was done by allele-specific PCR.
  
  
  RESULTS
  No significant difference in the distribution of FcγRIIa H/R and FcγRIIIa NA1/NA2 genotypes or their respective alleles was observed in GCP patients and healthy subjects. For FcγRIIIa F/V genetic polymorphism, the homozygous V/V genotype and V allele were significantly overrepresented in GCP patients while F/F genotype and F allele in controls.
  
  
  CONCLUSIONS
  The present study demonstrates that FcγRIIIa V/V genotype, as well as V allele, could be a possible risk factor for chronic periodontitis in South Indian population.
authors.affiliation: Department of Periodontology, Faculty of Dental Sciences, SGT University, Gurgaon, India.
authors.forename: Veenu Madaan
authors.initials: VM
authors.lastname: Hans
authors.affiliation: Department of Periodontology and Implantology, Bapuji Dental College and Hospital, Davangere, Karnataka, India.
authors.forename: Dhoom Singh
authors.initials: DS
authors.lastname: Mehta
authors.affiliation: Department of Dentistry, ESIC Medical College and Hospital, Faridabad, Haryana, India.
authors.forename: Mayank
authors.initials: M
authors.lastname: Hans
keywords: Fc gamma receptor; South Indian; generalized chronic periodontitis; genetic polymorphism