title: Pentraxin-3 Predicts Long-Term Cardiac Events in Patients with Chronic Heart Failure.
abstract: The aim of this study was to investigate the long-term prognostic value of pentraxin-3 (PTX3) in patients with chronic heart failure (CHF). 377 patients were prospectively followed up for 3 years to determine cardiac events including cardiac death or rehospitalization for worsening heart failure. The plasma PTX3 levels were significantly higher in CHF patients than in healthy subjects (p < 0.001), and they increased with advancing New York Heart Association (NYHA) Functional Classification (p < 0.001). Plasma PTX3 levels in CHF patients with cardiac events were significantly higher than in event-free patients (p < 0.001). We determined the normal upper limit of plasma PTX3 levels from the mean + 2 SD value of 64 control subjects (3.64 ng/mL). A Kaplan-Meier analysis revealed that patients with increased PTX3 (≥ 3.64 ng/mL) were at a higher risk for cardiac events than those without increased PTX3 (p < 0.01). A multifactorial Cox proportional hazards model showed that increased PTX3 ( ≥ 3.64 ngImL) was an independent risk factor for cardiac events in CHF patients (hazard ratio (HR) = 4.224, p < 0.01; 95% CI: 1.130-15.783). Plasma PTX3 levels are a long-term independent predictor of prognosis in patients with CHF.
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; Department of Cardiology, Yinzhou People's Hospital, Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Liu
authors.affiliation: Clinical Laboratory Center, Yinzhou People's Hospital, Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Guo
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Yao
authors.affiliation: Department of Cardiology, Yinzhou People's Hospital, Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Chunming
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Yinzhou People's Hospital, Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Guozhong
authors.initials: G
authors.lastname: Chen
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Clinical Laboratory Center, Yinzhou People's Hospital, Medical School of Ningbo University, Ningbo 315040, China.
authors.forename: Wangjun
authors.initials: W
authors.lastname: Yu
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Junbo
authors.initials: J
authors.lastname: Ge
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002681:China / Q000453:epidemiology; D002908:Chronic Disease; D016757:Death, Sudden, Cardiac / Q000453:epidemiology*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D000683:Serum Amyloid P-Component / Q000032:analysis*; D015996:Survival Rate; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins