title: Pyroptosis: Caspase-11 Unlocks the Gates of Death.
abstract: How inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.
authors.affiliation: Department of Biochemistry, University of Lausanne, 155 Ch. Des Boveresses, Epalinges 1066, Switzerland.
authors.forename: Aude
authors.initials: A
authors.lastname: de Gassart
authors.affiliation: Department of Biochemistry, University of Lausanne, 155 Ch. Des Boveresses, Epalinges 1066, Switzerland. Electronic address: fabio.martinon@unil.ch.
authors.forename: Fabio
authors.initials: F
authors.lastname: Martinon
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism*; D017630:Connexins / Q000378:metabolism*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000069292:Pyroptosis / Q000502:physiology*; D058486:Receptors, Purinergic P2X7 / Q000378:metabolism*; D012772:Shock, Septic / Q000378:metabolism*
chemical_list: D017630:Connexins; D009419:Nerve Tissue Proteins; D058486:Receptors, Purinergic P2X7; D020169:Caspases
keywords: Pyroptosis; caspase-11; danger signals; inflammation