title: Association of β-Adrenergic Receptor Gene Polymorphisms With Acute Coronary Syndrome and Cardiovascular Risk Factors in an Arab Population.
abstract: We evaluated the association between beta-adrenergic receptor genes (ADRB1 and ADRB2) polymorphism, cardiovascular risk, and acute coronary syndrome (ACS) in individuals from an Arab ethnicity. A total of 388 Qatari participants were assessed and genotyped for ADRB1 (rs1801252 & rs1801253) and ADRB2 (rs1042718 & rs1042713) polymorphisms using allele-specific PCR. Minor allele frequencies (MAF) in each single-nucleotide polymorphisms (SNPs) did not show statistically significant difference between cases and controls. A higher proportion of patients with ACS had homozygous minor alleles (GG) for rs1801253 (28.8% vs 17.1%; P = .019) compared with controls. Among cases with ACS, there was an association of minor allele frequency (G) for rs1801253 with severe coronary artery stenosis (0.485 vs 0.428; P = .04) than that of insignificant stenosis (<50% stenosis). There was a 3-fold increased risk of significant coronary stenosis in patients with diabetes mellitus (DM) and carrier of rs1801253 genotypes with dominant model (P = .01) and recessive model (P = .05). There is a possible synergic association between DM, carrier of ADRB1 (Arg389Gly) variants, and significant coronary artery stenosis among Arabs. Further prospective studies with larger sample sizes are warranted to support our findings.
authors.affiliation: Clinical Medicine, Weill Cornell Medical School, Qatar Clinical Research, Hamad General Hospital, Qatar Cardiology, Internal Medicine, Ahmed Maher Teaching Hospital, Cairo, Egypt aymanco65@yahoo.com.
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Menyar
authors.affiliation: Health Sciences Department, CAS-Qatar University, Doha, Qatar Physiology Department, Al-Mansoura Faculty of Medicine, Egypt.
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Rizk
authors.affiliation: Clinical Research, Hamad General Hospital, Qatar.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Asim
authors.affiliation: Vascular Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: Hassan
authors.initials: H
authors.lastname: Al-Thani
authors.affiliation: Department of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Akram
authors.initials: A
authors.lastname: Elgendy
authors.affiliation: Cardiology Department, Heart Hospital, Doha, Qatar.
authors.forename: Jassim
authors.initials: J
authors.lastname: Al-Suwaidi
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging / Q000208:ethnology / Q000235:genetics*; D000368:Aged; D018912:Arabs / Q000235:genetics*; D016022:Case-Control Studies; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000208:ethnology / Q000235:genetics*; D003920:Diabetes Mellitus / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011780:Qatar / Q000453:epidemiology; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C547787:ADRB1 protein, human; C553443:ADRB2 protein, human; D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2
keywords: Arab; beta receptors; coronary artery disease; diabetes; genotypes; polymorphism