title: Mass Spectrometry in Clinical Laboratory: Applications in Biomolecular Analysis.
abstract: Mass spectrometry (MS) is a technique that can identify analytes on the basis of mass-to-charge (m/z) ratio. Although this technique has been used in research and specialized clinical laboratories for decades, however, in recent years, MS has been increasingly used in routine clinical laboratories. MS, especially when coupled to gas chromatography or liquid chromatography, provides very specific and often sensitive analysis of many analytes. Other advantages of MS include simultaneous analysis of multiple analytes (>100) and generally without need for specialized reagents. Commonly measured analytes by MS include drugs, hormones, and proteins.
authors.affiliation: Department of Pathology and Laboratory Medicine, Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO, 64108, USA. ugarg@cmh.edu.|University of Missouri School of Medicine, Kansas City, MO, USA. ugarg@cmh.edu.
authors.forename: Uttam
authors.initials: U
authors.lastname: Garg
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, USA.
authors.forename: Yan Victoria
authors.initials: YV
authors.lastname: Zhang
mesh_terms: D019963:Clinical Chemistry Tests / Q000379:methods*; D016903:Drug Monitoring; D004704:Endocrinology; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D008659:Metabolic Diseases / Q000378:metabolism
keywords: Clinical laboratory; Endocrinology; Gas chromatography; Hormones and proteins; Liquid chromatography; Mass spectrometry; Newborn screening; Tandem mass spectrometry