title: What We Can Learn from "Super-responders".
abstract: This review discusses the state of the art of knowledge to help decision making in patients who are candidates for cardiac resynchronization therapy (CRT) and to analyze the long-term total and cardiac mortality, sudden death, and CRT with a defibrillator intervention rate, as well as the evolution of echocardiographic parameters in patients with a left ventricular (LV) ejection fraction of greater than 50% after CRT implantation. Owing to normalization of LV function in super-responders, the need for a persistent defibrillator backup is also considered.
authors.affiliation: University Hospital Santa Maria della Misericordia, Udine 33100, Italy. Electronic address: proclemer.alessandro@aoud.sanita.fvg.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Proclemer
authors.affiliation: Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Daniele
authors.initials: D
authors.lastname: Muser
authors.affiliation: University Hospital Santa Maria della Misericordia, Udine 33100, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Facchin
mesh_terms: D058406:Cardiac Resynchronization Therapy / Q000379:methods / Q000401:mortality / Q000706:statistics & numerical data*; D000066491:Clinical Decision-Making / Q000379:methods; D003131:Combined Modality Therapy / Q000379:methods / Q000401:mortality / Q000706:statistics & numerical data; D015897:Comorbidity; D017147:Defibrillators, Implantable / Q000706:statistics & numerical data*; D019317:Evidence-Based Medicine; D006333:Heart Failure / Q000401:mortality* / Q000517:prevention & control*; D006801:Humans; D018579:Patient Selection; D020127:Recovery of Function; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000401:mortality* / Q000517:prevention & control*
keywords: CRT; Cardiac resynchronization therapy; Left ventricular ejection fraction; Left ventricular function