title: Benzodiazepine, psychotropic medication, and dementia: A population-based cohort study.
abstract: Benzodiazepine use has been associated with increased risk of dementia. However, it remains unclear whether the risk relates to short or long half-life benzodiazepines and whether it extends to other psychotropic drugs.
  
  
  
  Prospective cohort study among 8240 individuals ≥65, interviewed on medication use. Incident dementia confirmed by an end point committee after a multistep procedure.
  
  
  
  During a mean of 8 years of follow-up, 830 incident dementia cases were observed. Users of benzodiazepines at baseline had a 10% increased risk of dementia (adjusted hazard ratio [HR], 1.10; 95% confidence interval, 0.90-1.34). However, long half-life (>20 hours) benzodiazepine users had a marked increased risk of dementia (HR = 1.62; 1.11-2.37) compared with short half-life users (HR = 1.05; 0.85-1.30). Users of psychotropics had an increased risk of dementia (HR = 1.47; 1.16-1.86).
  
  
  
  Results of this large, prospective study show increased risk of dementia for long half-life benzodiazepine and psychotropic use.
authors.affiliation: Inserm Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, Bordeaux, France; University of Bordeaux, Bordeaux, France.
authors.forename: Dalia
authors.initials: D
authors.lastname: Shash
authors.affiliation: Inserm Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, Bordeaux, France; University of Bordeaux, Bordeaux, France.
authors.forename: Tobias
authors.initials: T
authors.lastname: Kurth
authors.affiliation: Inserm Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, Bordeaux, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Bertrand
authors.affiliation: Inserm Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, Bordeaux, France; University of Bordeaux, Bordeaux, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Dufouil
authors.affiliation: University of Bordeaux, Bordeaux, France; Inserm Unit 897-Epidemiology and Biostatistics Research Center (U897) - Team Epidemiology and Neuropsychology of Cerebral Aging, Bordeaux, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Barberger-Gateau
authors.affiliation: Inserm Unit 1061-Neuropsychiatry: Epidemiological and Clinical Research, University of Montpellier, Montpellier, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Berr
authors.affiliation: Inserm Unit 1061-Neuropsychiatry: Epidemiological and Clinical Research, University of Montpellier, Montpellier, France.
authors.forename: Karen
authors.initials: K
authors.lastname: Ritchie
authors.affiliation: University of Bordeaux, Bordeaux, France; Inserm Unit 897-Epidemiology and Biostatistics Research Center (U897) - Team Epidemiology and Neuropsychology of Cerebral Aging, Bordeaux, France.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Dartigues
authors.affiliation: University of Bordeaux, Bordeaux, France; Inserm Unit 657-Pharmacoepidemiology and Evaluation of the Impact of Health Products on Populations, Bordeaux, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Bégaud
authors.affiliation: Inserm Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, Bordeaux, France; University of Bordeaux, Bordeaux, France.
authors.forename: Annick
authors.initials: A
authors.lastname: Alpérovitch
authors.affiliation: Inserm Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, Bordeaux, France; University of Bordeaux, Bordeaux, France. Electronic address: christophe.tzourio@u-bordeaux.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
mesh_terms: D000368:Aged; D001569:Benzodiazepines / Q000009:adverse effects*; D003704:Dementia / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012306:Risk
chemical_list: D011619:Psychotropic Drugs; D001569:Benzodiazepines
keywords: Alzheimer's disease; Benzodiazepine; Cohort studies; Dementia; Psychotropic medication