title: Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum.
abstract: During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 μM. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics.
authors.affiliation: Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Ham
authors.affiliation: Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea.
authors.forename: Weon-Jong
authors.initials: WJ
authors.lastname: Yoon
authors.affiliation: Nakdonggang National Institute of Biological Resources, Chungbuk 742-350, Korea.
authors.forename: Wook Jae
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: Nakdonggang National Institute of Biological Resources, Chungbuk 742-350, Korea.
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Kim
authors.affiliation: Cosmetic Science Center, Department of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea.
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Baik
authors.affiliation: R & D Center, Hanbul Cosmetics Co., Chungbuk 369-830, Korea.
authors.forename: Jin Hwa
authors.initials: JH
authors.lastname: Kim
authors.affiliation: R & D Center, Hanbul Cosmetics Co., Chungbuk 369-830, Korea.
authors.forename: Geun Soo
authors.initials: GS
authors.lastname: Lee
authors.affiliation: Cosmetic Science Center, Department of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea.
authors.forename: Nam Ho
authors.initials: NH
authors.lastname: Lee
authors.affiliation: Cosmetic Science Center, Department of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea.
authors.forename: Chang-Gu
authors.initials: CG
authors.lastname: Hyun
keywords: Sargassum micracanthum; brown alga; inflammation; isoketochabrolic acid