title: Serum Irisin Level is Higher and Related with Insulin in Acanthosis Nigricans-related Obesity.
abstract: OBJECTIVE
  Acanthosis nigricans (AN) is proved to be a skin phenotype of hyperinsulinemia especially in obese patients. Irisin is a new myokine which plays an important role in metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes. The role of irisin in the development of AN-related obesity is not yet understood. In this study, we aimed to investigate the relationship between irisin and AN-related obesity. Patients & Measurements: 30 obese patients without AN (OB group), 30 obese patients with AN (AN group), and 20 age-matched healthy volunteers (control group, CON) were included in this study. Weight, BMI, lipid profile, FFA, UA, and CRP were measured in all participants. Oral Glucose Tolerance tests (OGTT) were performed and serum glucose and plasma insulin were measured at 0, 30, 60,120 and 180 min. The AUC (area under curve) of glucose and insulin was calculated. Serum irisin was measured by ELISA.
  
  
  RESULTS
  Hyperinsulinemia is found in both AN and OB groups. The AN group had higher levels of insulin but better blood glucose tolerance and insulin response. The difference in irisin levels between the 3 groups was statistically significant, with the AN group showing the highest serum level of irisin. Serum irisin levels were positively correlated with BMI, and fasting insulin.
  
  
  CONCLUSIONS
  AN is a state of hyperinsulinmia and has better insulin response and glucose tolerance compared to obese patients without AN. Serum irisin may be a protective factor against impaired beta cell function in obesity with AN.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai, China.
authors.forename: J Q
authors.initials: JQ
authors.lastname: Chen
authors.affiliation: Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Fang
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai, China.
authors.forename: K X
authors.initials: KX
authors.lastname: Song
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai, China.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Huang
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai, China.
authors.forename: S Y
authors.initials: SY
authors.lastname: Chai
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai, China.
authors.forename: L
authors.initials: L
authors.lastname: Bu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai, China.
authors.forename: S
authors.initials: S
authors.lastname: Qu
mesh_terms: D000052:Acanthosis Nigricans / Q000097:blood* / Q000150:complications; D000328:Adult; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood* / Q000209:etiology; D007328:Insulin / Q000097:blood*; D050417:Insulin-Secreting Cells / Q000378:metabolism; D009765:Obesity / Q000097:blood* / Q000209:etiology
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins; D007328:Insulin