title: Loop gain in severely obese women with obstructive sleep apnoea.
abstract: Our objective was to assess whether obstructive sleep apnoea (OSA) patients were characterised by a reduced central CO2 controller gain (CG) and an enhanced plant gain (PG). We matched three groups of women (n=10 per group) enrolled in a previous study (Essalhi et al., J. Asthma. 50: 565-572, 2013): obese women with a respiratory disturbance index (RDI)≥15/h and with a RDI<15, and lean women without OSA (RDI<5). Tidal ventilation recordings during wakefulness with end-tidal PCO2 monitoring allowed the assessment of loop gain (LG) and its components (PG and CG). LG were similar for the three groups (p=0.844) while both PG and CG depicted significant differences (p=0.046 and p=0.011, respectively). Obese women with OSA were characterised by an increased PG and a reduced CG as compared to obese women without OSA. A negative relationship between CG and RDI (rho=-0.46, p=0.008) was evidenced. In conclusion, OSA in women is associated with a reduced central CO2 controller gain and an enhanced plant gain.
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Service de Physiologie-Clinique de la Dyspnée, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, 75006 Paris, France.
authors.forename: Plamen
authors.initials: P
authors.lastname: Bokov
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Service de Physiologie-Clinique de la Dyspnée, 75015 Paris, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Essalhi
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Service de Physiologie-Clinique de la Dyspnée, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, 75006 Paris, France. Electronic address: christophe.delclaux@aphp.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Delclaux
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D010100:Oxygen / Q000097:blood*; D012119:Respiration / Q000276:immunology*; D012129:Respiratory Function Tests; D020181:Sleep Apnea, Obstructive / Q000150:complications*; D013990:Tidal Volume / Q000502:physiology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen
keywords: Loop gain; Respiratory control; Sleep apnoea