title: Evaluation of a Low Energy, Low Density, Non-Ablative Fractional 1927 nm Wavelength Laser for Facial Skin Resurfacing.
abstract: OBJECTIVE
  We investigated the safety, tolerability and efficacy of a low energy low density, non-ablative fractional 1,927-nm laser in the treatment of facial photodamage, melasma, and post inflammatory hyperpigmentation.
  
  
  METHODS
  Prospective non-randomized trial.
  
  
  METHODS
  Single center, private practice with a dedicated research department.
  
  
  METHODS
  Subjects with clinically diagnosed facial photodamage, melasma, or post inflammatory hyperpigmentation.
  
  
  METHODS
  Subjects received four to six treatments at 14-day intervals (+/- 3 days) with a low energy low density non-ablative fractional 1,927-nm laser (Solta Hayward, CA) with an energy level of 5 mJ, and density coverage of either 5%, 7.5%, or 10%, with a total of up to 8 passes.
  
  
  METHODS
  Blinded assessment of clinical photos for overall improvement at one and three months post final treatment. Investigator improvement scores, and subject pain and satisfaction scores for overall improvement were recorded as well.
  
  
  RESULTS
  We enrolled 23 subjects, average age 45.0 years (range, 25-64 years), 22 with Fitzpatrick Skin Types I-IV and 1 with Type VI, with facial photodamage, melasma, or post inflammatory hyperpigmentation. Approximately 55% of subjects reported marked to very significant improvement at one and three months post final treatment. Blinded assessment of photography of 20 subjects revealed an average of moderate improvement at one-month follow up and mild to moderate improvement at three months. Average subject pain score was 3.4/10 during treatment.
  
  
  CONCLUSIONS
  Favorable outcomes were demonstrated using the low energy low density, non-ablative fractional 1,927-nm laser in facial resurfacing for photodamage, melasma, and post inflammatory hyperpigmentation. Results were maintained at the 3-month follow up, as demonstrated by investigator and subject assessments, as well as blinded evaluations by three independent dermatologists utilizing photographs obtained from a standardized facial imaging device.
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: Brauer
authors.forename: Hamad
authors.initials: H
authors.lastname: Alabdulrazzaq
authors.forename: Yoon-Soo Cindy
authors.initials: YS
authors.lastname: Bae
authors.forename: Roy G
authors.initials: RG
authors.lastname: Geronemus
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017495:Hyperpigmentation / Q000628:therapy*; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D008548:Melanosis / Q000628:therapy*; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D012867:Skin / Q000378:metabolism / Q000473:pathology; D015595:Skin Aging; D013997:Time Factors; D016896:Treatment Outcome