title: Structural analysis of bovine norovirus protruding domain.
abstract: We determined a structure of a bovine (genogroup III, GIII) norovirus capsid protruding (P) domain using X-ray crystallography. The bovine P domain was reminiscent of other norovirus genogroups (GI, GII, GIV, and GV), but closely matched the human GI P domain. We also identified a monoclonal antibody that was capable of binding the five different (GI-GV) P domains. Our data suggests that genetically diverse noroviruses still contain common epitopes.
authors.affiliation: Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg 69120, Germany; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg 69120, Germany.
authors.forename: Bishal Kumar
authors.initials: BK
authors.lastname: Singh
authors.affiliation: Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg 69120, Germany; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg 69120, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Koromyslova
authors.affiliation: Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg 69120, Germany; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg 69120, Germany. Electronic address: g.hansman@dkfz.de.
authors.forename: Grant S
authors.initials: GS
authors.lastname: Hansman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D002213:Capsid / Q000276:immunology* / Q000648:ultrastructure*; D036022:Capsid Proteins / Q000235:genetics / Q000276:immunology* / Q000648:ultrastructure*; D002417:Cattle; D002418:Cattle Diseases / Q000821:virology; D003429:Cross Reactions / Q000276:immunology; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008969:Molecular Sequence Data; D029322:Norovirus / Q000145:classification / Q000648:ultrastructure*; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D036022:Capsid Proteins
keywords: Antibodies; Bovine norovirus; Cross-reactivity