title: Concomitant Medical Conditions and Therapies Preclude Accurate Classification of Children With Severe or Severe Complicated Clostridium difficile Infection.
abstract: Severe and severe complicated Clostridium difficile infections (SCDI/SCCDI) were retrospectively assessed in a pediatric cohort. Underlying medical conditions and concomitant medical therapy preclude accurate classification of children with SCDI/SCCDI, using current CDI severity definitions. Revised CDI definitions in children should focus on more objective, age-appropriate, and CDI-specific markers of severity.
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Illinois Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Larry K
authors.initials: LK
authors.lastname: Kociolek
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Illinois Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Sameer J
authors.initials: SJ
authors.lastname: Patel
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Illinois Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Stanford T
authors.initials: ST
authors.lastname: Shulman
authors.affiliation: Department of Medicine, Edward Hines, Jr. VA Hospital, Hines, Illinois Loyola University Chicago Stritch School of Medicine, Maywood, Illinois.
authors.forename: Dale N
authors.initials: DN
authors.lastname: Gerding
mesh_terms: D002648:Child; D002675:Child, Preschool; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000145:classification / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Clostridium difficile; complicated; definition; pediatric; severe