title: Targeted Drug Delivery System for Platinum-based Anticancer Drugs.
abstract: Platinum-based (Pt-based) anticancer drugs have been recognised as one of the most effective drugs for clinical treatment of malignant tumors due to its unique mechanism of action and broad range of anticancer spectrum. But, there are still some limitations such as side effects, drug resistance/cross resistance, no-specific targeting, becoming obstacles to restrict its expanding of clinical application. Targeted drug delivery system (TDDS) is a promising strategy for the research of novel Pt-based anticancer drugs. A variety of TDDS have been explored to improve the antitumor activity of Pt-based drugs such as nanoparticle drug systems, polymer-drug systems, drugs-macrocyclic compounds systems, etc. The review concentrates on recent development of various targeted drug delivery techniques, which could provide more opportunities for the development of Pt-based drugs with better efficiency, lower toxicity and less resistance.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. gczasd@163.com.
authors.forename: Chuanzhu
authors.initials: C
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ji
authors.initials: J
authors.lastname: Chen
authors.forename: Tianshuai
authors.initials: T
authors.lastname: Wang
authors.forename: Yunxu
authors.initials: Y
authors.lastname: Qian
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Peng
authors.initials: P
authors.lastname: Dong
authors.affiliation: Engineering Laboratory for Advanced Battery and Material of Yunnan Province, Kunming 650500, China. yingjie@kmust.edu.cn.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D047028:Macrocyclic Compounds; D009944:Organoplatinum Compounds; D011108:Polymers