title: Bupropion abuse resulting in hypomania in a geriatric amphetamine user: A case report.
abstract: BACKGROUND
  Bupropion is a commonly prescribed antidepressant which acts on norepinephrine and dopamine neurotransmission. It is structurally similar to amphetamine. Several cases of recreational bupropion ingestion, insufflation, and injection have been reported in the literature.
  
  
  METHODS
  Here we report a case of bupropion abuse in a 79-year-old gentleman with a history of alcohol and amphetamine use disorders, resulting in hypertension and hypomanic symptoms.
  
  
  RESULTS
  To our knowledge, this is the first case of bupropion abuse documented in an older adult. The literature with respect to bupropion abuse is reviewed, and the matter of stimulant abuse in older adults is considered.
  
  
  CONCLUSIONS
  This case emphasizes the need to consider bupropion's abuse potential when prescribing it to older adults with risk factors for substance abuse.
authors.affiliation: Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Aviva
authors.initials: A
authors.lastname: Rostas
authors.affiliation: Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.|Baycrest Health Sciences, Department of Psychiatry, Toronto, Ontario, Canada.
authors.forename: Uri
authors.initials: U
authors.lastname: Wolf
mesh_terms: D000368:Aged; D019969:Amphetamine-Related Disorders / Q000150:complications* / Q000523:psychology*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000150:complications*; D016642:Bupropion / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000150:complications; D008297:Male; D063487:Prescription Drug Misuse / Q000523:psychology*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion