title: [Estrogen receptor-β expression in laryngeal carcinoma: correlation with the expression of epithelial-mesenchymal transition specific biomarkers].
abstract: OBJECTIVE
  To detect the expression of ERβ in laryngeal carcinoma and the its correlation with the expression of epithelial-mesenchymal transition(EMT) specific biomarkers.
  
  
  METHODS
  Picture MT-Pv9000 was used to detect ERβ and EMT in 72 cases of human aqueous laryngeal carcinoma and 8 cases of adjacent non-neoplastic laryngeal mucosa by immunohistochemistry.
  
  
  RESULTS
  The positive rates of ERβ in tumors and adjacent non-neoplastic laryngeal mucosa were 27.78% and 25.00%, respectively. The differences were not significant (P > 0.05). The abnormal expression rates of E-cadherin and β-catenin were 61.11% and 76.39% respectively. The expression of ERβ correlated negatively with the loss of E-cadherin, nuclear translocation of β-catenin and increased TNM stage. The differences were significant (P < 0.05).
  
  
  CONCLUSIONS
  The positive expressions of ERβ suggest a good prognosis in the differentiation, clinical stages and lymphatic metastasis of the laryngeal carcinoma. The underlying mechanism may be related with the abnormal expressions of E-cadherin and β-catenin.
authors.forename: Lan
authors.initials: L
authors.lastname: Mu
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Gu
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.forename: Wang
authors.initials: W
authors.lastname: Li
mesh_terms: D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition; D047629:Estrogen Receptor beta / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008207:Lymphatic Metastasis; D051176:beta Catenin / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D047629:Estrogen Receptor beta; D051176:beta Catenin