title: Canine IgA nephropathy: a case report.
abstract: Immunoglobulin (Ig) A nephropathy is a rare form of canine glomerular disease. This report describes a case of canine IgA nephropathy showing characteristics typical of human IgA nephropathy. An 8-year-old, spayed female Miniature Dachshund showed persistent severe proteinuria without azotemia. She was receiving long-term glucocorticoid therapy due to chronic gastritis and an intra-abdominal suture granuloma. A renal biopsy demonstrated mesangial proliferative glomerulonephritis with predominantly mesangial IgA deposition and electron-dense deposits in the paramesangium. These findings closely resembled those of human IgA nephropathy. Glucocorticoid treatment was discontinued, and the angiotensin-converting enzyme inhibitor enalapril was administrated as an antiproteinuric agent. The proteinuria subsequently went into remission, and the patient has maintained good condition without recurrence.
authors.affiliation: Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-8580, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yabuki
authors.forename: Takako
authors.initials: T
authors.lastname: Shimokawa Miyama
authors.forename: Moeko
authors.initials: M
authors.lastname: Kohyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology* / Q000652:urine; D004285:Dogs; D005260:Female; D005922:Glomerulonephritis, IGA / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D011507:Proteinuria / Q000662:veterinary