title: ERS-PERK signaling pathway-mediated Nrf2/ARE-HO-1 axis: A novel therapeutic target for attenuating myocardial ischemia and reperfusion injury.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Jiefang Road 238, Wuchang, 430060 Wuhan, PR China.
authors.forename: Jichun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Jiefang Road 238, Wuchang, 430060 Wuhan, PR China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Jiefang Road 238, Wuchang, 430060 Wuhan, PR China. Electronic address: jianghongwhu@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000818:Animals; D059865:Endoplasmic Reticulum Stress / Q000235:genetics*; D051547:Heme Oxygenase-1 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D017202:Myocardial Ischemia / Q000235:genetics* / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000235:genetics* / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction; D019892:eIF-2 Kinase / Q000235:genetics* / Q000378:metabolism
chemical_list: D051547:Heme Oxygenase-1; D051267:NF-E2-Related Factor 2; D019892:eIF-2 Kinase; C495635:NFE2L2 protein, human; C496541:HMOX1 protein, human
keywords: Endoplasmic reticulum stress (ERS); Heme oxygenase-1 (HO-1); Myocardial ischemia and reperfusion injury; Nuclear factor-erythroid 2-related factor 2 (Nrf2); Protein kinase-like ER kinase (PERK)