title: Fundamental aspects of solid dispersion technology for poorly soluble drugs.
abstract: The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug-polymer two-component system, the drug-polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology.
authors.affiliation: Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Janssen Research and Development, Johnson & Johnson Company, Randor 19087, PA, USA.
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Dai
keywords: Drug–polymer interaction; Phase separation; Poorly soluble drug; Solid dispersion