title: Chronic exposure to aluminum and risk of Alzheimer's disease: A meta-analysis.
abstract: A meta-analysis was performed to investigate whether chronic exposure to aluminum (Al) is associated with increased risk of Alzheimer's disease (AD). Eight cohort and case-control studies (with a total of 10567 individuals) that met inclusion criteria for the meta-analysis were selected after a thorough literature review of PubMed, Web of Knowledge, Elsevier ScienceDirect and Springer databases up to June, 2015. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of included studies. Q test and I(2) statistic were used to examine heterogeneity between selected studies. The overall odds ratio (OR) was calculated using a fixed-effect model because no significant heterogeneity between studies was found. No publication bias was observed based on a funnel plot and Egger's test. Results showed that individuals chronically exposed to Al were 71% more likely to develop AD (OR: 1.71, 95% confidence interval (CI), 1.35-2.18). The finding suggests that chronic Al exposure is associated with increased risk of AD.
authors.affiliation: School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan 250012 Shandong, PR China.
authors.forename: Zengjin
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan 250012 Shandong, PR China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Wei
authors.affiliation: School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan 250012 Shandong, PR China.
authors.forename: Junlin
authors.initials: J
authors.lastname: Yang
authors.affiliation: School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan 250012 Shandong, PR China.
authors.forename: Jinning
authors.initials: J
authors.lastname: Suo
authors.affiliation: School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan 250012 Shandong, PR China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Chen
authors.affiliation: University of Tennessee Health Science Center, United States.
authors.forename: Xianchen
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan 250012 Shandong, PR China. Electronic address: zhao.xl@sdu.edu.cn.
authors.forename: Xiulan
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000535:Aluminum / Q000633:toxicity*; D000544:Alzheimer Disease / Q000139:chemically induced*; D004785:Environmental Pollutants / Q000633:toxicity; D006801:Humans; D012306:Risk
chemical_list: D004785:Environmental Pollutants; D000535:Aluminum
keywords: Aluminum; Alzheimer’; Meta-analysis; Odds ratio; s disease