title: Pharmaceutical Composition for Improving Physical Working Capacity.
abstract: For development of a pharmaceutical composition improving physical performance, effects of various drugs and their combinations on forced swimming test performance were studied on laboratory rats. Maximum increase in animal performance was produced by a 3-component composition asparcam+mildronate+metaprote in proportion of 5.0, 10.7, and 14.3 mg/kg, respectively. No changes in blood serum biochemistry and morphological composition of the peripheral blood were detected after single intragastric administration of the composition.
authors.affiliation: Yu. A. Gagarin Saratov State Technological University, Saratov, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Baulin
authors.affiliation: Yu. A. Gagarin Saratov State Technological University, Saratov, Russia.
authors.forename: S M
authors.initials: SM
authors.lastname: Rogacheva
authors.affiliation: Yu. A. Gagarin Saratov State Technological University, Saratov, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Afanaseva
authors.affiliation: Yu. A. Gagarin Saratov State Technological University, Saratov, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Zabanova
authors.affiliation: Yu. A. Gagarin Saratov State Technological University, Saratov, Russia. karagaycheva.julia@yandex.ru.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Karagaycheva
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001224:Aspartic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D054874:Athletic Performance; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004441:Ecdysterone / Q000008:administration & dosage / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects; D008763:Methylhydrazines / Q000008:administration & dosage / Q000494:pharmacology*; D058573:Performance-Enhancing Substances / Q000008:administration & dosage / Q000494:pharmacology*; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology; D010807:Physical Endurance / Q000187:drug effects*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013550:Swimming; D016474:Weight-Bearing
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; D000697:Central Nervous System Stimulants; D004338:Drug Combinations; D008763:Methylhydrazines; D058573:Performance-Enhancing Substances; D011506:Proteins; D001224:Aspartic Acid; D004441:Ecdysterone; D010672:Phenytoin; C049825:bemethyl; C050147:3-(2,2,2-trimethylhydrazine)propionate; D000255:Adenosine Triphosphate
keywords: forced swimming test; laboratory animals; pharmaceutical composition; physical performance