title: Management of Gonorrhea in Adolescents and Adults in the United States.
abstract: Gonorrhea is the second most commonly reported notifiable disease in the United States and is associated with serious health sequelae, including pelvic inflammatory disease, infertility, and ectopic pregnancy. Treatment for gonorrhea has been complicated by antimicrobial resistance. Neisseria gonorrhoeae has developed resistance to each of the antimicrobials that were previously recommended as first-line treatment regimens, and current treatment options are severely limited. This article summarizes the key questions and data that were discussed at the Sexually Transmitted Diseases (STD) Treatment Guidelines Expert Consultation meeting in April 2013, and the rationale for the 2015 Centers for Disease Control and Prevention STD treatment guidelines for gonococcal infections in adolescents and adults. Key issues addressed include whether to change the dosage of ceftriaxone and azithromycin used in the recommended dual treatment regimen, whether to continue to list dual treatment with cefixime and azithromycin as an alternative treatment regimen, and management of gonococcal infections in persons with severe cephalosporin allergy or suspected treatment failure.
authors.affiliation: Division of STD Prevention, Centers for Disease Control and Prevention.
authors.forename: Sarah
authors.initials: S
authors.lastname: Kidd
authors.affiliation: Division of STD Prevention, Centers for Disease Control and Prevention Division of Infectious Diseases, Emory University, Atlanta, Georgia.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Workowski
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D002443:Ceftriaxone / Q000494:pharmacology / Q000627:therapeutic use; D002487:Centers for Disease Control and Prevention, U.S.; D019468:Disease Management; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone
keywords: Neisseria gonorrhoeae; drug therapy; gonorrhea