title: [Retrospective Cytogenetic Dose Evaluation. I. Chromosome Aberration Levels in Remote Periods after Acute External Exposure in Different Situations].
abstract: Cytogenetic analysis of peripheral blood lymphocyte cultures of 22 persons was performed in remote terms after acute external γ-, γ-β- or γ-neutron irradiation as a result of various accidents using the classical me- thod. The initial dose estimates were obtained using physical calculations, the method of measuring the EPR signal in tooth enamel, according to haematological and/or cytogenetic parameters. The purpose of this study was to obtain evidence about the state of the lymphocyte chromosome apparatus of people approxi- mately 17-50 years after an accidental radiation exposure. In general, elevated levels of chromosome aberra- tions were detected. An average correlation was observed between the atypical chromosome frequency and absorbed dose. It is proposed to use the obtained results in the future to explore the possibility of retrospective dose evaluation on the basis of a special computer program.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Nugs
authors.forename: I K
authors.initials: IK
authors.lastname: Khvostunov
authors.forename: E V
authors.initials: EV
authors.lastname: Goloub
authors.forename: M G
authors.initials: MG
authors.lastname: Kozlova
authors.forename: N M
authors.initials: NM
authors.lastname: Nadejina
authors.forename: I A
authors.initials: IA
authors.lastname: Galstian
mesh_terms: D002869:Chromosome Aberrations / Q000528:radiation effects*; D020732:Cytogenetic Analysis; D003627:Data Interpretation, Statistical; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000097:blood / Q000235:genetics*; D011834:Radiation Monitoring / Q000379:methods*; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release; D012189:Retrospective Studies; D012426:Russia; D013997:Time Factors