title: Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests.
abstract: Superparamagnetic nanoparticles and a functional, degradable polymer matrix based on poly(ethylene glycol) are combined to enable fully degradable magnetic microdevices for minimally invasive biomedical applications. A bioinspired helical microrobot platform mimicking Escherichia coli bacteria is fabricated and actuated using weak rotating magnetic fields. Locomotion based on corkscrew propulsion, targeted drug delivery, and low-degradation-product cytotoxicity are demonstrated.
authors.affiliation: Micro and Nanosystems, ETH Zurich, Tannenstrasse 3, 8092, Zurich, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Peters
authors.affiliation: Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, 8092, Zurich, Switzerland.
authors.forename: Marcus
authors.initials: M
authors.lastname: Hoop
authors.affiliation: Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, 8092, Zurich, Switzerland.
authors.forename: Salvador
authors.initials: S
authors.lastname: Pané
authors.affiliation: Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, 8092, Zurich, Switzerland.
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Nelson
authors.affiliation: Micro and Nanosystems, ETH Zurich, Tannenstrasse 3, 8092, Zurich, Switzerland.
authors.forename: Christofer
authors.initials: C
authors.lastname: Hierold
mesh_terms: D016475:3T3 Cells; D000179:Acrylates / Q000737:chemistry*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity*; D004867:Equipment Design; D059346:Magnets / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D012371:Robotics / Q000295:instrumentation*
chemical_list: D000179:Acrylates; D004337:Drug Carriers; D011409:Propylene Glycols; C437167:poly(ethylene glycol)diacrylate; D011092:Polyethylene Glycols; C027992:pentaerythrityl triacrylate
keywords: cytotoxicity; degradable composites; superparamagnetic particles; swimming microrobots; targeted drug delivery