title: Treatment of zinc toxicosis in a dog with chelation using d-penicillamine.
abstract: OBJECTIVE
  To describe chelation therapy with d-penicillamine for treatment of zinc toxicosis in a dog.
  
  
  METHODS
  A 1.5-year-old intact female Maltese dog weighing 2.7 kg was presented with acute, progressive anorexia, lethargy, pigmenturia, and melena. The owner reported that the dog had ingested a hook from a dog leash made of a zinc-based alloy 9 days prior. A blood transfusion was administered and an abdominal radiograph revealed a metal-dense foreign body in the stomach. Laboratory findings revealed a serum zinc concentration of 1845.12 μg/dL (reference interval, 70-200 μg/dL) and a decreased hematocrit that remained low despite removal of the zinc foreign body. On day 3, another blood transfusion was performed and d-penicillamine therapy was instituted. After the administration of d-penicillamine, the clinical signs and hemogram progressively improved and the dog was discharged 2 days later. On day 9 after initial presentation, the hematocrit and platelet values were within normal limits and the serum zinc concentration was 280.16 μg/dL.
  
  
  CONCLUSIONS
  This case demonstrates the use of d-penicillamine in the treatment of zinc toxicosis. Serum zinc concentration appeared to decline more rapidly after administration of d-penicillamine than before chelation therapy. This is the first report to evaluate serial serum zinc concentrations before and during chelation therapy with d-penicillamine.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, South Korea.
authors.forename: Ye-Rin
authors.initials: YR
authors.lastname: Lee
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, South Korea.
authors.forename: Min-Hee
authors.initials: MH
authors.lastname: Kang
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, South Korea. parkhee@konkuk.ac.kr.
authors.forename: Hee-Myung
authors.initials: HM
authors.lastname: Park
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005547:Foreign Bodies / Q000188:drug therapy / Q000662:veterinary*; D010396:Penicillamine / Q000008:administration & dosage / Q000627:therapeutic use*; D011041:Poisoning / Q000628:therapy / Q000662:veterinary; D015032:Zinc / Q000506:poisoning*
chemical_list: D002614:Chelating Agents; D010396:Penicillamine; D015032:Zinc
keywords: Zn; canine; chelation; hemolytic anemia; intoxication