title: Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential.
abstract: Dysregulation of microRNAs (miRNAs) has been implicated in almost every known survival mechanisms utilized by cancer cells. One of such mechanisms, anoikis resistance, plays a pivotal role in enabling metastasis by allowing cancer cells to circumvent cell death induced by lack of attachment. Understanding how miRNAs regulate the various anoikis pathways has become the research question of increasing number of studies published in the past years. Through these studies, a growing list of miRNAs has been identified to be important players in promoting either anoikis or resistance to anoikis. In this review, we will be focusing on these miRNAs and how the findings from those studies can contribute to novel therapeutic strategies against cancer progression. We will be examining miRNAs that have been found to promote anoikis sensitivity in numerous cancer types followed by miRNAs that inhibit anoikis. In addition, we will also be taking a look at major signaling pathways involved in the action of the each of these miRNAs to gain a better understanding on how miRNAs regulate anoikis.
authors.affiliation: Institute of Biological Sciences (Genetics & Molecular Biology), Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Sharan
authors.initials: S
authors.lastname: Malagobadan
authors.affiliation: Institute of Biological Sciences (Genetics & Molecular Biology), Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia ; Centre for Research in Biotechnology for Agriculture (CEBAR), University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Noor Hasima
authors.initials: NH
authors.lastname: Nagoor
mesh_terms: D000818:Animals; D023102:Anoikis / Q000235:genetics*; D002470:Cell Survival; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D012334:RNA, Neoplasm