title: [Influence of diethyl sulfate (DES) mutagenesis on growth properties and pigment secondary metabolites of Phellinus igniarius].
abstract: The diethyl sulfate (DES) mutagenesis was chosen for the mutagenic treatment to Phellinus igniarius, and the relationship of mutagenesis time and death rate was investigated with 0.5% DES. The differences of mycelial growth speed, liquid fermentation mycelia biomass, morphology and pigment classes of secondary metabolites production speed and antioxidant activities of metabolite products were discussed. The study displayed that DES mutagenesis could change mycelial morphology without obvious effect on mycelium growth, and the DES mutagenesis improved antioxidant activities of the active ingredients of P. igniarius and had more antioxidant activity of hypoxia/sugar PC12 nerve cells than that of P. igniarius.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Xin-yuan
authors.initials: XY
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.forename: Xiu-li
authors.initials: XL
authors.lastname: Wu
mesh_terms: D001487:Basidiomycota / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D016296:Mutagenesis; D009153:Mutagens / Q000494:pharmacology*; D025282:Mycelium / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D010860:Pigments, Biological / Q000032:analysis / Q000378:metabolism*; D064210:Secondary Metabolism / Q000187:drug effects; D013463:Sulfuric Acid Esters / Q000494:pharmacology*
chemical_list: D009153:Mutagens; D010860:Pigments, Biological; D013463:Sulfuric Acid Esters; C011612:diethyl sulfate