title: Epidemiological study of soft-tissue sarcomas in Ireland.
abstract: Soft-tissue sarcomas (STS) account for 1% of adult and 7% of pediatric malignancies. Histopathology and classification of these rare tumors requires further refinements. The aim of this paper is to describe the current incidence and survival of STS from 1994 to 2012 in Ireland and compare these with comparably coded international published reports. This is a retrospective, population study based on the data from the National Cancer Registry of Ireland (NCRI). Incidence and relative survival rates for STS in Ireland were generated. Incidence of STS based on gender, age and anatomical location was examined. Annual mean incidence rate (European Age Standardized) in Ireland between 1994 and 2012 was 4.48 ± 0.15 per 100,000 person-years. The overall relative 5-year survival rate of STS for the period 1994-2011 in Ireland was 56%, which was similar to that reported in the U.K. but lower than in most of Europe and U.S.A. Survival rate fluctuated over the period examined, declining slightly in females but showing an increase in males. STS incidence trends in Ireland were comparable to international reports. Survival trends of STS were significantly different between Ireland and other European countries, requiring further study to understand causation.
authors.affiliation: Department of Surgery, Adelaide and Meath Hospital, Tallaght, Dublin, Ireland.
authors.forename: Nikita
authors.initials: N
authors.lastname: Bhatt
authors.affiliation: National Cancer Registry Ireland, Cork, Ireland.
authors.forename: Sandra
authors.initials: S
authors.lastname: Deady
authors.affiliation: Department of Surgery, Adelaide and Meath Hospital, Tallaght, Dublin, Ireland.
authors.forename: Amy
authors.initials: A
authors.lastname: Gillis
authors.affiliation: Department of Medical Oncology, Adelaide and Meath Hospital, Tallaght, Dublin, Ireland.
authors.forename: Alexia
authors.initials: A
authors.lastname: Bertuzzi
authors.affiliation: Department of Histopathology, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Aurelie
authors.initials: A
authors.lastname: Fabre
authors.affiliation: Department of Radiology, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Eric
authors.initials: E
authors.lastname: Heffernan
authors.affiliation: Department of Radiation Oncology, St Luke's Hospital, Dublin, Ireland.
authors.forename: Charles
authors.initials: C
authors.lastname: Gillham
authors.affiliation: Department of Orthopaedics, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Gary
authors.initials: G
authors.lastname: O'Toole
authors.affiliation: Department of Surgery, Adelaide and Meath Hospital, Tallaght, Dublin, Ireland.
authors.forename: Paul F
authors.identifier: http://orcid.org/0000-0002-9297-240X
authors.initials: PF
authors.lastname: Ridgway
mesh_terms: D000367:Age Factors; D005260:Female; D006801:Humans; D015994:Incidence; D007494:Ireland / Q000453:epidemiology; D008297:Male; D009026:Mortality; D011159:Population Surveillance; D012189:Retrospective Studies; D012509:Sarcoma / Q000453:epidemiology* / Q000401:mortality; D012737:Sex Factors
keywords: Incidence; rare cancers; soft-tissue sarcomas; survival