title: [THE EFFECT OF EPOXYGENASE INHIBITORS ON Ca(2+)-RESPONSES INDUCED BY GLUTOXIM AND MOLIXAN IN MACROPHAGES].
abstract: Using Fura-2AM microfluorimetry the possible involvement of epoxygenase pathway of arachidonic acid metabolism in the effect of glutoxim and molixan on intracellular Ca2+ concentration in rat peritoneal macrophages was investigated. It was shown for the first time that preincubation of the macrophages with epoxygenase inhibitors, proadifen and econazole, significantly decreases the intracellular Ca2+ concentration increase induced by glutoxim and molixan. The addition of the epoxygenase inhibitors during the already developed store-dependent Ca(2+)-entry induced by glutoxim or molixan partially inhibits Ca(2+)-entry. The obtained data suggest the involvement of the products and/or enzymes of epoxygenase pathway of the arachidonic acid metabolism in the glutoxim and molixan effect on the Ca2+ signaling processes in macrophages.
authors.forename: L S
authors.initials: LS
authors.lastname: Milenina
authors.forename: Z I
authors.initials: ZI
authors.lastname: Krutetskaya
authors.forename: A A
authors.initials: AA
authors.lastname: Naumova
authors.forename: S N
authors.initials: SN
authors.lastname: Butov
authors.forename: N I
authors.initials: NI
authors.lastname: Krutetskaya
authors.forename: V G
authors.initials: VG
authors.lastname: Antonov
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects*; D004464:Econazole / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011335:Proadifen / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004791:Enzyme Inhibitors; D009842:Oligopeptides; C462699:glutoxim; D004464:Econazole; D011335:Proadifen