title: The relationship between five non-synonymous polymorphisms within three XRCC genes and gastric cancer risk in a Han Chinese population.
abstract: We aimed to assess the association of five non-synonymous polymorphisms within three X-ray repair cross-complementing group (XRCC) genes with gastric cancer risk in Han Chinese. Genotyping was determined in 693 gastric cancer patients and 681 healthy controls. Statistical analyses were completed with SPSS (version 20.0) and Haplo.stats (version 1.6.11). The genotypes of XRCC1 gene rs25487 polymorphism (P = 0.003) differed significantly between patients and controls, even after the Bonferroni correction (P < 0.05/5), and this polymorphism was significantly associated with gastric cancer after adjusting for age, sex, body mass index, smoking, drinking, especially under a dominant model (odds ratio or OR; 95 % confidence interval or CI; P 1.59; 1.20-2.00; 0.001). In multiple-marker analysis, the most common allele combination was C-G-G-G-C (alleles in order of rs1799782, rs25489, rs25487, rs3218536, rs861539), which was overrepresented in controls relative to patients (adjusted simulated P = 0.0001). Contrastingly, the frequency of allele combination C-G-A-G-C was significantly higher in patients than in controls (adjusted simulated P = 0.0009), and this combination was associated with a strikingly increased risk of gastric cancer (OR; 95 % CI; P 2.39; 1.32-4.31; 0.0040) after the Bonferroni correction (P < 0.05/11) and adjusting for confounders. Our findings demonstrated that XRCC1 gene rs25487 polymorphism might play a leading role in pronounced susceptibility to gastric cancer in Han Chinese.
authors.affiliation: Gastric and Intestine Department, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Huansong
authors.initials: H
authors.lastname: Gong
authors.affiliation: Gastric and Intestine Department, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zou
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, No. 346, Guanhai Road, Laishan District, Yantai, 264003, Shandong, China. mimi_mj@yeah.net.
authors.forename: Jia
authors.initials: J
authors.lastname: Mi
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, No. 346, Guanhai Road, Laishan District, Yantai, 264003, Shandong, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, No. 346, Guanhai Road, Laishan District, Yantai, 264003, Shandong, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, No. 346, Guanhai Road, Laishan District, Yantai, 264003, Shandong, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Yan
authors.affiliation: Institute of Molecular Imaging, Binzhou Medical University, Yantai, Shandong, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Institute of Pharmacology, Binzhou Medical University, No. 346, Guanhai Road, Laishan District, Yantai, 264003, Shandong, China. spchang11725@126.com.
authors.forename: Shuping
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, No. 346, Guanhai Road, Laishan District, Yantai, 264003, Shandong, China. tiangengshandong@yeah.net.
authors.forename: Geng
authors.initials: G
authors.lastname: Tian
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D012306:Risk; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C110901:X-ray repair cross complementing protein 3; C000619371:XRCC1 protein, human; C113187:XRCC2 protein, human
keywords: Case-control association study; DNA repair system; Gastric cancer; Polymorphism; X-ray repair cross-complementing group