title: Serum Thiol/Disulphide Homeostasis in Preeclampsia.
abstract: OBJECTIVE
  To determine the serum thiol/disulphide homeostasis in preeclampsia and to investigate the association with clinical parameters.
  
  
  METHODS
  Forty-three pregnant women with preeclampsia and 43 healthy, uncomplicated pregnancies were included in the study. Native thiol, disulphide, and total thiol concentrations were measured by a novel automated method.
  
  
  RESULTS
  The serum native and total thiol levels were significantly lower in preeclampsia when compared with the healthy group (p < 0.001). There were significant correlations among the homeostatic parameters and preeclampsia.
  
  
  CONCLUSIONS
  Serum thiol/disulphide homeostasis may have a role in the pathogenesis and can be evaluated with the clinical and laboratory findings of preeclampsia.
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Ozler
authors.affiliation: b Department of Clinical Biochemistry , Yildirim Beyazit University Faculty of Medicine , Ankara , Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Efser
authors.initials: E
authors.lastname: Oztas
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Ali Ozgur
authors.initials: AO
authors.lastname: Ersoy
authors.affiliation: b Department of Clinical Biochemistry , Yildirim Beyazit University Faculty of Medicine , Ankara , Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Ergin
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Sucak
authors.affiliation: b Department of Clinical Biochemistry , Yildirim Beyazit University Faculty of Medicine , Ankara , Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Neselioglu
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
keywords: Preeclampsia; thiol/disulphide homeostasis.