title: Detection of diabetic macular oedema: validation of optical coherence tomography using both foveal thickness and intraretinal fluid.
abstract: No studies have yet evaluated jointly central foveal thickness (CFT) and the presence of intraretinal fluid (PIF) to diagnose diabetic macular oedema (DMO) using optic coherence tomography (OCT). We performed a cross-sectional observational study to validate OCT for the diagnosis of DMO using both CFT and PIF assessed by OCT (3D OCT-1 Maestro). A sample of 277 eyes from primary care diabetic patients was assessed in a Spanish region in 2014.
  
  
  RESULTS
  DMO diagnosed by stereoscopic mydriatic fundoscopy. OCT was used to measure CFT and PIF. A binary logistic regression model was constructed to predict the outcome using CFT and PIF. The area under the ROC curve (AUC) of the model was calculated and non-linear equations used to determine which CFT values had a high probability of the outcome (positive test), distinguishing between the presence or absence of PIF. Calculations were made of the sensitivity, specificity, and the positive (PLR) and negative (NLR) likelihood ratios. The model was validated using bootstrapping methodology. A total of 37 eyes had DMO. AUC: 0.88. Positive test: CFT ≥90 µm plus PIF (≥310 µm if no PIF). Clinical parameters: sensitivity, 0.83; specificity, 0.89; PLR, 7.34; NLR, 0.19. The parameters in the validation were similar. In conclusion, combining PIF and CFT provided a tool to very precisely discriminate the presence of DMO. Similar studies are needed to provide greater scientific evidence for the use of PIF in the diagnosis of DMO.
authors.affiliation: Ophthalmology Service, General Hospital of Elche , Elche, Alicante , Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Hernández-Martínez
authors.affiliation: Department of Clinical Medicine, Miguel Hernández University , San Juan de Alicante, Alicante , Spain ; Research Unit, Elda Hospital , Elda, Alicante , Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Palazón-Bru
authors.affiliation: Ophthalmology Service, General Hospital of Elche , Elche, Alicante , Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Azrak
authors.affiliation: Ophthalmology Service, General Hospital of Elche , Elche, Alicante , Spain.
authors.forename: Aída
authors.initials: A
authors.lastname: Navarro-Navarro
authors.affiliation: Ophthalmology Service, General Hospital of Elche , Elche, Alicante , Spain ; Department of Clinical Medicine, Miguel Hernández University , San Juan de Alicante, Alicante , Spain.
authors.forename: Manuel Vicente
authors.initials: MV
authors.lastname: Baeza-Díaz
authors.affiliation: Ophthalmology Service, General Hospital of Elche , Elche, Alicante , Spain.
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Martínez-Toldos
authors.affiliation: Department of Clinical Medicine, Miguel Hernández University , San Juan de Alicante, Alicante , Spain ; Research Unit, Elda Hospital , Elda, Alicante , Spain.
authors.forename: Vicente Francisco
authors.initials: VF
authors.lastname: Gil-Guillén
keywords: Diabetes complications; Macular oedema; Optical coherence tomography; Vision screening