title: The spectrum of activity of the small RNA DsrA: not so narrow after all.
abstract: For a long time, the small regulatory RNA DsrA has been considered as a regulator with a narrow spectrum of action due to its restricted targetome. Since the first reports on DsrA characterization, only two targets of DsrA have been described: rpoS and hns mRNAs, encoding the sigma factor σS and the nucleoid-associated protein H-NS, respectively. Recently, the scope of DsrA targetome has been expanded by the characterization of two negatively regulated mRNAs, mreB and rbsD, involved in cell wall biosynthesis and ribose metabolism, respectively. In this review, we summarize new insights in DsrA-mediated regulation and emphasize the versatility of DsrA modes of action.
authors.affiliation: RNA Group, Department of Biochemistry, Université de Sherbrooke, 3201 Jean Mignault Street, Sherbrooke, QC, J1E 4K8, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Lalaouna
authors.affiliation: RNA Group, Department of Biochemistry, Université de Sherbrooke, 3201 Jean Mignault Street, Sherbrooke, QC, J1E 4K8, Canada. eric.masse@usherbrooke.ca.
authors.forename: Eric
authors.initials: E
authors.lastname: Massé
mesh_terms: D002473:Cell Wall; D005786:Gene Expression Regulation; D008957:Models, Genetic; D012333:RNA, Messenger / Q000235:genetics; D058727:RNA, Small Untranslated / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D058727:RNA, Small Untranslated
keywords: DsrA; Escherichia coli; Gene expression regulation; Small regulatory RNA; sRNA