title: Anti-obesity and lipid lowering effects of Cymodocea nodosa sulphated polysaccharide on high cholesterol-fed-rats.
abstract: This study aims to evaluate for the first time the effects of Cymodocea nodosa sulphated polysaccharide (CNSP) on lipase activity in vitro and in vivo to high fat diet (HFD)-rats on body weight, lipid profile and liver-kidney functions. The administration of CNSP decreases the body weight and inhibits lipase activity of obese rats in serum and intestine as compared with untreated HDF-rats. This decrease in lipase activity leads to lipid regulation shown by the decrease of total cholesterol (T-Ch), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) and an increase in high density lipoprotein cholesterol (HDL-C) levels in HFD-rats. Additionally, CNSP administration to HFD-rats induces anti-oxidant activity observed by the increase of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels and protects liver-kidney functions proven by a decrease in the levels of toxicity parameters in blood.
authors.affiliation: a Laboratory of Plant Biotechnology , Faculty of Sciences of Sfax , Sfax , Tunisia .|d Stazione Zoologica 'A. Dohrn', Functional and Evolutionary Ecology Laboratory , Punta S. Pietro, Ischia (Naples) , Italy .
authors.forename: Rihab
authors.initials: R
authors.lastname: Ben Abdallah Kolsi
authors.affiliation: a Laboratory of Plant Biotechnology , Faculty of Sciences of Sfax , Sfax , Tunisia .
authors.forename: Amel
authors.initials: A
authors.lastname: Ben Gara
authors.affiliation: b Biochemistry Laboratory , CHU Hedi Chaker , Sfax , Tunisia .
authors.forename: Rim
authors.initials: R
authors.lastname: Chaaben
authors.affiliation: c Laboratory of Animal Ecophysiology , Faculty of Sciences of Sfax , Tunisia , and.
authors.forename: Abdelfattah
authors.initials: A
authors.lastname: El Feki
authors.affiliation: d Stazione Zoologica 'A. Dohrn', Functional and Evolutionary Ecology Laboratory , Punta S. Pietro, Ischia (Naples) , Italy .
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Patti
authors.affiliation: a Laboratory of Plant Biotechnology , Faculty of Sciences of Sfax , Sfax , Tunisia .
authors.forename: Lotfi
authors.initials: L
authors.lastname: El Feki
authors.affiliation: a Laboratory of Plant Biotechnology , Faculty of Sciences of Sfax , Sfax , Tunisia .
authors.forename: Karima
authors.initials: K
authors.lastname: Belghith
mesh_terms: D035961:Alismatales / Q000737:chemistry*; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D001835:Body Weight; D002374:Catalase / Q000378:metabolism; D002784:Cholesterol / Q000633:toxicity*; D059305:Diet, High-Fat / Q000009:adverse effects*; D050356:Lipid Metabolism / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000032:analysis; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013439:Sulfhydryl Reagents / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts; D011134:Polysaccharides; D013439:Sulfhydryl Reagents; D017392:Thiobarbituric Acid Reactive Substances; D002784:Cholesterol; D002374:Catalase; D013482:Superoxide Dismutase
keywords: Polysaccharide; liver-kidney functions; obesity