title: Cell biology and immunology lessons taught by Legionella pneumophila.
abstract: Legionella pneumophila is a facultative intracellular pathogen capable of replicating within a broad range of hosts. One unique feature of this pathogen is the cohort of ca. 300 virulence factors (effectors) delivered into host cells via its Dot/Icm type IV secretion system. Study of these proteins has produced novel insights into the mechanisms of host function modulation by pathogens, the regulation of essential processes of eukaryotic cells and of immunosurveillance. In this review, we will briefly discuss the roles of some of these effectors in the creation of a niche permissive for bacterial replication in phagocytes and recent advancements in the dissection of the innate immune detection mechanisms by challenging immune cells with L. pneumophila.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN47907, USA.
authors.forename: Wenhan
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN47907, USA. luoz@purdue.edu.
authors.forename: Zhao-Qing
authors.initials: ZQ
authors.lastname: Luo
mesh_terms: D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D016952:Legionella pneumophila / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology; D007877:Legionnaires' Disease / Q000276:immunology / Q000382:microbiology; D018448:Models, Immunological; D000069319:Type IV Secretion Systems / Q000276:immunology; D014774:Virulence / Q000276:immunology
chemical_list: D000069319:Type IV Secretion Systems
keywords: Type IV secretion; effectors; inflammasome; posttranslational modification; vesicle transport