title: Coronary endothelial function assessment using self-gated cardiac cine MRI and k-t sparse SENSE.
abstract: Electrocardiogram (ECG)-gated cine MRI, paired with isometric handgrip exercise, can be used to accurately, reproducibly, and noninvasively measure coronary endothelial function (CEF). Obtaining a reliable ECG signal at higher field strengths, however, can be challenging due to rapid gradient switching and an increased heart rate under stress. To address these limitations, we present a self-gated cardiac cine MRI framework for CEF measurements that operates without ECG signal.
  
  
  
  Cross-sectional slices of the right coronary artery (RCA) were acquired using a two-dimensional golden angle radial trajectory. This sampling approach, combined with the k-t sparse SENSE algorithm, allows for the reconstruction of both real-time images for self-gating signal calculations and retrospectively reordered self-gated cine images. CEF measurements were quantitatively compared using both the self-gated and the standard ECG-gated approach.
  
  
  
  Self-gated cine images with high-quality, temporal, and spatial resolution were reconstructed for 18 healthy volunteers. CEF as measured in self-gated images was in good agreement (R2= 0.60) with that measured by its standard ECG-gated counterpart.
  
  
  
  High spatial and temporal resolution cross-sectional cine images of the RCA can be obtained without ECG signal. The coronary vasomotor response to handgrip exercise compares favorably with that obtained with the standard ECG-gated method. Magn Reson Med 76:1443-1454, 2015. © 2015 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Department of Radiology, University Hospital and University of Lausanne, Lausanne, Switzerland. yerlyj.mri@gmail.com.|Center for Biomedical Imaging, Lausanne, Switzerland. yerlyj.mri@gmail.com.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Yerly
authors.affiliation: Department of Radiology, University Hospital and University of Lausanne, Lausanne, Switzerland.|Center for Biomedical Imaging, Lausanne, Switzerland.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ginami
authors.affiliation: Department of Radiology, University Hospital and University of Lausanne, Lausanne, Switzerland.|Center for Biomedical Imaging, Lausanne, Switzerland.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Nordio
authors.affiliation: Department of Radiology, University Hospital and University of Lausanne, Lausanne, Switzerland.|Center for Biomedical Imaging, Lausanne, Switzerland.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Coristine
authors.affiliation: Department of Radiology, University Hospital and University of Lausanne, Lausanne, Switzerland.|Center for Biomedical Imaging, Lausanne, Switzerland.
authors.forename: Simone
authors.initials: S
authors.lastname: Coppo
authors.affiliation: Cardiac MR Center, Service of Cardiology, University Hospital of Lausanne, Lausanne, Switzerland.
authors.forename: Pierre
authors.initials: P
authors.lastname: Monney
authors.affiliation: Department of Radiology, University Hospital and University of Lausanne, Lausanne, Switzerland.|Center for Biomedical Imaging, Lausanne, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Stuber
mesh_terms: D000328:Adult; D000465:Algorithms; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D017023:Coronary Angiography / Q000379:methods*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005080:Exercise Test / Q000379:methods; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
keywords: compressed sensing; coronary; endothelial function; golden angle; k-t sparse SENSE; self-gated cardiac cine