title: Selective Ophthalmic Artery Infusion Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience.
abstract: Selective ophthalmic artery infusion chemotherapy (SOAIC) is increasingly used to treat retinoblastoma. We report the toxicities and outcome of 19 eyes in 17 patients with retinoblastoma receiving SOAIC treatment between 2008 and 2013. From the 87 treatments, mild local reactions were common. Myelosuppression was more common after triple-agent SOAIC (melphalan, carboplatin, and topotecan) than single-agent melphalan. Ocular salvage was achieved in 11 of 19 eyes and associated with triple-agent therapy. SOAIC is a effective therapy for some retinoblastoma with manageable toxicity; however, systemic toxicity increases with increasing therapeutic intensity of SOAIC.
authors.affiliation: *Division of Oncology †Department of Radiology, Cincinnati Children's Hospital Medical Center ‡Department of Ophthalmology, University of Cincinnati, Cincinnati, OH.
authors.forename: Samantha T
authors.initials: ST
authors.lastname: Michaels
authors.forename: Todd A
authors.initials: TA
authors.lastname: Abruzzo
authors.forename: James J
authors.initials: JJ
authors.lastname: Augsburger
authors.forename: Zélia M
authors.initials: ZM
authors.lastname: Corrêa
authors.forename: Adam
authors.initials: A
authors.lastname: Lane
authors.forename: James I
authors.initials: JI
authors.lastname: Geller
mesh_terms: D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007261:Infusions, Intra-Arterial; D008297:Male; D008558:Melphalan / Q000008:administration & dosage* / Q000009:adverse effects; D009880:Ophthalmic Artery; D019572:Retinal Neoplasms / Q000188:drug therapy*; D012175:Retinoblastoma / Q000188:drug therapy*; D012189:Retrospective Studies; D019772:Topotecan / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D018906:Antineoplastic Agents, Alkylating; D019772:Topotecan; D016190:Carboplatin; D008558:Melphalan