title: [THE IMMUNOLOGIC INDICATORS IN PATIENTS WITH CARIES OF CONTACT SURFACES OF LATERAL TEETH].
abstract: The samplings of patients aged 18-45 years with caries of contact surfaces of lateral teeth (n=18) and healthy adults aged 18-20 years with intact teeth (n=18) were examined The saliva taken in rotary vial on empty stomach in amount of 3-4 mi served as assay for analysis. To identify secretory immunoglobulin A, interleukin lβ, interleukin-4 and interferon y saliva was centrifuged during 15 min under 1500 rpm. The supernatant fluid was analyzed using enzymoimmunoassay (test-systems "Vector-Best", Novosibirsk). The registration of reaction was implemented using multiscan Labsystem under wavelength 450 nm. The content of secretory immunoglobulin A was expressed in mg/l, cytokines - in pg/ml. It is demonstrated that in patients with caries average level of interleukin lβ was almost two times higher (p<0.05) than analogous indicator in healthy examined patients. In healthy patients average level of interferon γ significantly (more than in 10 times) exceeded upper limit of allowable standard and was higher (p<0.05) in comparison with such in patients with caries of contact surfaces. The analysis of content of secretory immunoglobulin A in saliva established that in healthy patients average values of the given indicator were higher (p<0.05) than in patients with caries of contact surfaces of lateral teeth. The lower content of secretory immunoglobulin A and interferon y against the background of increased level of interleukin lβ was detected in saliva of patients with caries of contact surfaces of lateral teeth. This occurrence can be considered as factor predisposing to development of caries process.
authors.forename: A V
authors.initials: AV
authors.lastname: Heigetyan
authors.forename: E A
authors.initials: EA
authors.lastname: Bragin
authors.forename: S Yu
authors.initials: SY
authors.lastname: Maksiukov
authors.forename: A V
authors.initials: AV
authors.lastname: Labushkina
authors.forename: E L
authors.initials: EL
authors.lastname: Alutina
authors.forename: G G
authors.initials: GG
authors.lastname: Harseeva
mesh_terms: D000293:Adolescent; D000328:Adult; D001641:Bicuspid / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D003731:Dental Caries / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000235:genetics / Q000276:immunology*; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D053583:Interleukin-1beta / Q000235:genetics / Q000276:immunology; D015847:Interleukin-4 / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry
chemical_list: D015415:Biomarkers; C508598:IL4 protein, human; D007071:Immunoglobulin A, Secretory; D053583:Interleukin-1beta; D015847:Interleukin-4; D007371:Interferon-gamma