title: Impact of common SNPs in VEGF gene on the susceptibility of osteosarcoma.
abstract: We conducted a case-control study to assess the role of vascular endothelial growth factor (VEGF) -634G/C, +936C/T, and +1612G/A genetic variations in the development of osteosarcoma in a Chinese population. This hospital-based case-control study examined 130 patients with osteosarcoma and 130 age- and gender-matched healthy controls from March 2011 and March 2013. Polymerase chain reaction-restriction fragment length polymorphism was applied to assess the VEGF -634G/C, +936C/T, and +1612G/A gene polymorphisms. Using conditional regression analysis, individuals carrying the TT genotype of VEGF +936C/T were found to be correlated with an elevated risk of osteosarcoma, with an adjusted odds ratio (95% confidence interval) of 2.70 (1.02-8.28). In conclusion, our study suggests that the TT genotype of VEGF +936C/T genetic variants is associated with an increased risk of osteosarcoma.
authors.affiliation: Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan, China.
authors.forename: G L
authors.initials: GL
authors.lastname: Hu
authors.affiliation: Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan, China.
authors.forename: G
authors.initials: G
authors.lastname: Ma
authors.affiliation: Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan, China jianghua_ming@126.com.
authors.forename: J H
authors.initials: JH
authors.lastname: Ming
mesh_terms: D000328:Adult; D044466:Asian People; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A