title: A novel graphene nanodots inlaid porous gold electrode for electrochemically controlled drug release.
abstract: A uniform graphene nanodots inlaid porous gold electrode was prepared via ion beam sputtering deposition (IBSD) and mild corrosion chemistry. HRTEM, SEM, AFM and XPS analyses revealed the successful fabrication of graphene nanodots inlaid porous gold electrode. The as-prepared porous electrode was used as π-orbital-rich drug loading platform to fabricate an electrochemically controlled drug release system with high performance. π-orbital-rich drugs with amino mioety, like doxorubicin (DOX) and tetracycline (TC), were loaded into the graphene nanodots inlaid porous gold electrode via non-covalent π-π stacking interaction. The amino groups in DOX and TC can be easily protonated at acidic medium to become positively-charged NH3(+), which allow these drug molecules to be desorbed from the porous electrode surface via electrostatic repulsion when positive potential is applied at the electrode. The drug loading and release experiment indicated that this graphene nanodots inlaid porous gold electrode can be used to conveniently and efficiently control the drug release electrochemically. Not only did our work provide a benign method to electrochemically controlled drug release via electrostatic repulsion process, it also enlighten the promising practical applications of micro electrode as a drug carrier for precisely and efficiently controlled drug release via embedding in the body.
authors.affiliation: College of Chemical Science and Engineering, Qingdao University, Qingdao 266071, China; Laboratory of Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China.
authors.forename: Jianmei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Biology, Medical College of Qingdao University, Qingdao 266071, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.affiliation: College of Chemical Science and Engineering, Qingdao University, Qingdao 266071, China; Laboratory of Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China.
authors.forename: Mengmei
authors.initials: M
authors.lastname: Cao
authors.affiliation: School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3217, Australia.
authors.forename: Na
authors.initials: N
authors.lastname: Kong
authors.affiliation: School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3217, Australia.
authors.forename: Wenrong
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Pathophysiology, Medical College of Qingdao University, Qingdao 266071, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Sun
authors.affiliation: College of Physics Science, Qingdao University, Qingdao 266071, China; Laboratory of Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China.
authors.forename: You
authors.initials: Y
authors.lastname: Meng
authors.affiliation: College of Chemical Science and Engineering, Qingdao University, Qingdao 266071, China; Laboratory of Fiber Materials and Modern Textile, Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, China. Electronic address: jliu@qdu.edu.cn.
authors.forename: Jingquan
authors.initials: J
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D013752:Tetracycline / Q000737:chemistry / Q000378:metabolism
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006046:Gold; D006108:Graphite; D004317:Doxorubicin; D013752:Tetracycline
keywords: Drug release; Electrochemistry; Electrostatic repulsion process; Graphene nanodots; Ion beam sputtering deposition; Porous gold