title: [Control of bone and cartilage lesions in rheumatoid arthritis with TNF inhibitors].
abstract: TNF inhibitors have provided the paradigm shift in the field of rheumatology. Now 5 TNF inhibitors(infliximab, etanercept, adalimumab, golimumab and certolizumab pegol)are available. Each agent has not only clinical efficacy but also suppressive effect of radiographic progression based on the large clinical trials. Prompt use of a TNF inhibitor after making a diagnosis of RA may be important to prevent joint deformities and to obtain better quality of life for RA patients.
authors.affiliation: Department of Rheumatology and Clinical Immunology,Saitama Medical Center, Saitama Medical University, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Amano
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002357:Cartilage Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D010010:Osteoclasts / Q000187:drug effects; D011859:Radiography; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha