title: Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion-induced ischaemia/reperfusion injury in rats.
abstract: The aim of this study was to investigate the antioxidant properties of udenafil citrate (1.4 mg kg(-1) -2.8 mg kg(-1) ), dexmedetomidine 25 μg kg(-1) and piracetam 200 mg kg(-1) administered on ipsilateral/contralateral testes after ischaemia in a rat model of testicular torsion/detorsion (T/D) and define its protective effect histologically. Fifty-six Wistar albino rats were included and randomly assigned into 6 groups. No intervention was performed in control group (Group 1, n = 8) and in torsion/detorsion group, (Group 2, n = 8). Udenafil 1.4 mg kg(-1) was given to torsion/detorsion group (Group 3, n = 10), udenafil 2.8 mg kg(-1) was given to torsion/detorsion group (Group 4, n = 10), piracetam 200 mg kg(-1) was given to torsion/detorsion group (Group 5, n = 10) and dexmedetomidine 25 μg kg(-1) was given to torsion/detorsion group (Group 6, n = 10) intraperitoneally after 60 mins of testicular torsion. Biochemical and histopathological testicular injury were evaluated. When the tissue was examined by TOS values, Group 3, Group 4 and Group 5 were significantly lower than Group 2. In contrary Group 6 values were significantly higher than Group 2. The increasing doses of udenafil demonstrated antioxidant properties on the testis tissue and histopathological that protects the testicles.
authors.affiliation: Faculty of Medicine, Department of Urology, University of Kirikkale, Kirikkale, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Tuglu
authors.affiliation: Faculty of Medicine, Department of Urology, University of Kirikkale, Kirikkale, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Yuvanc
authors.affiliation: Faculty of Medicine, Department of Urology, University of Firat, Elazıg, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Ozan
authors.affiliation: Faculty of Medicine, Department of Urology, University of Kirikkale, Kirikkale, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Bal
authors.affiliation: Faculty of Medicine, Department of Urology, University of Kirikkale, Kirikkale, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Yilmaz
authors.affiliation: Faculty of Medicine, Department of Pathology, University of Kirikkale, Kirikkale, Turkey.
authors.forename: P
authors.initials: P
authors.lastname: Atasoy
authors.affiliation: Faculty of Medicine, Department of Biochemistry, University of Kirikkale, Kirikkale, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Kisa
authors.affiliation: Faculty of Medicine, Department of Urology, University of Kirikkale, Kirikkale, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Batislam
mesh_terms: D000818:Animals; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D010889:Piracetam / Q000627:therapeutic use*; D020011:Protective Agents / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D013086:Spermatic Cord Torsion / Q000150:complications* / Q000188:drug therapy; D013449:Sulfonamides / Q000627:therapeutic use*; D016896:Treatment Outcome; D000096926:Benzenesulfonamides
chemical_list: D020927:Dexmedetomidine; D010889:Piracetam; D020011:Protective Agents; D011743:Pyrimidines; D013449:Sulfonamides; C419664:udenafil; D000096926:Benzenesulfonamides
keywords: Dexmedetomidine; piracetam; total antioxidant capacity (TAC); total oxidant status (TOS); udenafil