title: Assessment of ovarian reserve in euthyroid adolescents with Hashimoto thyroiditis.
abstract: OBJECTIVE
  We aimed to investigate the ovarian function and reserve in euthyroid adolescents (TSH < 2.5 mIU/L) diagnosed with Hashimoto thyroiditis (HT).
  
  
  METHODS
  This case-control study included 30 adolescent girls (mean age 15.1 ± 1.4 years) newly diagnosed as HT with presence of high thyroid antibodies with gland heterogeneity in ultrasound and age-matched 30 healthy female subjects. Anti-ovarian antibody (AOAb), LH/FSH ratio, estradiol, anti-mullerian hormone (AMH), inhibin-B, total testosterone, antral follicle count, ovarian volumes and uterine length were measured. The clinical, laboratory, and ultrasound data of the HT and control groups were compared.
  
  
  RESULTS
  There were no significant differences between the girls with HT and healthy controls in relation to LH/FSH ratio, estradiol and inhibin-B levels. AOAb (p = 0.02), AMH (p = 0.007) and total testosterone levels were higher in HT group than the control group (p = 0.03). AOAb level was found to be positively correlated with LH/FSH ratio (p = 0.03), AMH (p = 0.01) and inhibin-B (p < 0.001) in HT group.
  
  
  CONCLUSIONS
  This study demonstrated that the adolescent girls diagnosed with autoimmune thyroiditis had normal ovarian reserve based on measurements of AMH, inhibin B, FSH, LH/FSH ratio, estradiol and antral follicle counts.
authors.affiliation: a Department of Pediatric Endocrinology and Diabetes .
authors.forename: Ozgur
authors.initials: O
authors.lastname: Pirgon
authors.affiliation: a Department of Pediatric Endocrinology and Diabetes .
authors.forename: Cigdem
authors.initials: C
authors.lastname: Sivrice
authors.affiliation: b Department of Pediatric Radiology, Faculty of Medicine , S. Demirel University , Isparta , Turkey , and.
authors.forename: Hakan
authors.initials: H
authors.lastname: Demirtas
authors.affiliation: c Department of Pediatric Endocrinology and Diabetes, Faculty of Medicine , Katip Celebi University , Izmir , Turkey.
authors.forename: Bumin
authors.initials: B
authors.lastname: Dundar
mesh_terms: D000293:Adolescent; D054304:Anti-Mullerian Hormone / Q000097:blood; D000906:Antibodies / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D050031:Hashimoto Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007265:Inhibins / Q000097:blood; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D065851:Ovarian Reserve; D014463:Ultrasonography
chemical_list: D000906:Antibodies; C422364:inhibin B; D007265:Inhibins; D054304:Anti-Mullerian Hormone
keywords: Adolescent; Hashimoto thyroiditis; anti-ovarian antibody; autoimmunity; ovarian reserve