title: Evaluation of transabdominal ultrasound after oral administration of an echoic cellulose-based gastric ultrasound contrast agent for gastric cancer.
abstract: BACKGROUND
  With the remarkable improvements in ultrasound equipment, transabdominal ultrasound after oral administration of an echoic cellulose-based gastric ultrasound contrast agent (TUS-OCCA) has recently been suggested to be effective in initial screening of gastric cancer. The aim of this study was to evaluate the diagnostic value of TUS-OCCA for gastric cancer.
  
  
  METHODS
  Consecutive patients with gastric cancers who underwent resection in our hospital were enrolled. Before the lesion was resected, TUS-OCCA examination was performed by a skilled examiner who was blinded to the site, size, and endoscopy diagnosis of the lesion. TUS-OCCA findings were compared with those of endoscopy and pathological diagnoses as the gold standard.
  
  
  RESULTS
  There were a total of 288 consecutive patients enrolled in the study, including 228 with advanced gastric cancers (T2-T4 stage), 50 with early gastric cancer (26 with stage T1b and 24 with stage T1a), and 10 with high-grade intraepithelial neoplasia. TUS-OCCA had a detection rate of 100% (228/228) for advanced gastric cancers, 77% (20/26) for stage T1b, 67% (16/24) for stage T1a, and 60% (6/10) for high-grade intraepithelial neoplasia. The majority of patients with undetectable neoplasms using TUS-OCCA were obese (body mass index, 28.7-31.8 kg/m(2)). The overall accuracy of TUS-OCCA in determining the T stage of gastric cancer was 77.3% (62.5% for T1a, 70% for T1b, 71.1% for T2, 85.2% for T3, and 73.3% for T4).
  
  
  CONCLUSIONS
  These findings indicate that TUS-OCCA achieved a high detection rate for gastric cancers and was useful in assessing the degree of gastric cancer invasion.
authors.affiliation: Ultrasound Department, Sheng Jing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province, 110004, People's Republic of China. liuzj1@sj-hospital.org.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Endoscopy Center, Sheng Jing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China. guojt@sj-hospital.org.
authors.forename: Jintao
authors.initials: J
authors.lastname: Guo
authors.affiliation: Endoscopy Center, Sheng Jing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China. 154118924@qq.com.
authors.forename: Shupeng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Surgical Department, Sheng Jing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China. zhaoyicmu2@126.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Ultrasound Department, Sheng Jing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province, 110004, People's Republic of China. lijingcmu@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Ultrasound Department, Sheng Jing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province, 110004, People's Republic of China. renweidongcmu@aliyun.com.
authors.forename: Weidong
authors.initials: W
authors.lastname: Ren
authors.affiliation: Ultrasound Department, Sheng Jing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province, 110004, People's Republic of China. tangshaoshancmu@163.com.
authors.forename: Shaoshan
authors.initials: S
authors.lastname: Tang
authors.affiliation: Ultrasound Department, Sheng Jing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province, 110004, People's Republic of China. xielimeicmu@163.com.
authors.forename: Limei
authors.initials: L
authors.lastname: Xie
authors.affiliation: Ultrasound Department, Sheng Jing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province, 110004, People's Republic of China. huangyingcmu@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Endoscopy Center, Sheng Jing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China. sunsiyucmu@aliyun.com.
authors.forename: Siyu
authors.initials: S
authors.lastname: Sun
authors.affiliation: Ultrasound Department, Sheng Jing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province, 110004, People's Republic of China. huanglipingcmu@163.com.
authors.forename: Liping
authors.initials: L
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002482:Cellulose / Q000008:administration & dosage*; D003287:Contrast Media / Q000008:administration & dosage*; D055088:Early Detection of Cancer; D004724:Endoscopy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D002482:Cellulose