title: Parallel activities and interactions between antimicrobial peptides and complement in host defense at the airway epithelial surface.
abstract: Antimicrobial peptides and complement components contribute to host defense as well as inflammation and tissue injury in the respiratory tract. The airway epithelial surface is the main site of action of these immune effectors, and airway epithelial cells contribute markedly to their local production. Whereas both antimicrobial peptides and complement display overlapping functions, it is increasingly clear that both effector mechanisms also interact. Furthermore, excessive or uncontrolled release of antimicrobial peptides as well as complement activation may contribute to inflammatory lung diseases. Therefore, further knowledge of interactions between these systems may provide more insight into the pathogenesis of a range of lung diseases. In this review, recent findings on the functions, collaborations and other interactions between antimicrobial peptides and complement are discussed with a specific focus on the airway epithelium.
authors.affiliation: Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: p.s.hiemstra@lumc.nl.
authors.forename: Pieter S
authors.initials: PS
authors.lastname: Hiemstra
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000276:immunology*; D003165:Complement System Proteins / Q000235:genetics / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D008168:Lung / Q000276:immunology / Q000473:pathology; D020545:Respiratory Mucosa / Q000276:immunology* / Q000473:pathology; D012141:Respiratory Tract Infections / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D023181:Antimicrobial Cationic Peptides; D003165:Complement System Proteins
keywords: Airway epithelial cells; Antimicrobial peptides; Complement; Innate immunity; Lung