title: Correlated responses of respiratory disease and immune capacity traits of Landrace pigs selected for Mycoplasmal pneumonia of swine (MPS) lesion.
abstract: Five generations of Landrace pigs selected for average daily gain, backfat thickness, Mycoplasmal pneumonia of swine (MPS) lesion score, and plasma cortisol levels, was executed to decrease the MPS lesion score. Genetic parameters and correlated genetic responses for respiratory disease and peripheral blood immune traits were estimated in 1395 Landrace pigs. We estimated the negative genetic correlation of MPS lesion score with phagocytic activity (PA) at 7 weeks of age (-0.67). The breeding values of PA at 7 weeks of age and 105 kg body weight and the correlated selection response of the ratio of granular leukocytes to lymphocytes at 105 kg body weight were significantly increased, and sheep red blood cell-specific antibody production (AP) was significantly decreased in a selection-dependent manner. Increasing of natural immunological indicators (e.g. PA) and decreasing of humoral immunological indicator (e.g. AP) were observed due to genetically decreasing MPS lesion score.
authors.affiliation: Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan.|NARO Institute of Livestock and Grassland Science, Ibaraki, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Okamura
authors.affiliation: Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan.
authors.forename: Kouki
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Onodera
authors.affiliation: Miyagi Livestock Experimental Station, Osaki, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kadowaki
authors.affiliation: Miyagi Livestock Experimental Station, Osaki, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kojima-Shibata
authors.affiliation: Miyagi Livestock Experimental Station, Osaki, Japan.
authors.forename: Eisaku
authors.initials: E
authors.lastname: Suzuki
authors.affiliation: Division of Animal Sciences, National Institute of Agrobiological Sciences, Tsukuba, Japan.
authors.forename: Hirohide
authors.initials: H
authors.lastname: Uenishi
authors.affiliation: NARO Institute of Livestock and Grassland Science, Ibaraki, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Satoh
authors.affiliation: Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000235:genetics / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006854:Hydrocortisone / Q000097:blood; D007962:Leukocytes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D010587:Phagocytosis / Q000235:genetics / Q000276:immunology; D045729:Pneumonia of Swine, Mycoplasmal / Q000235:genetics* / Q000276:immunology*; D019655:Quantitative Trait, Heritable; D012140:Respiratory Tract Diseases / Q000235:genetics / Q000276:immunology* / Q000662:veterinary*; D013552:Swine / Q000235:genetics* / Q000276:immunology*; D013553:Swine Diseases / Q000235:genetics / Q000276:immunology*
chemical_list: D006854:Hydrocortisone
keywords: genetic parameter; genetic trend; immunity; pig; respiratory disease