title: Adenomyoepithelioma with carcinoma of the breast: A report of two cases and a review of the literature.
abstract: We herein described two cases of adenomyoepithelioma (AME) with carcinoma of the breast. Both of them were Japanese women, and they presented with a mass in their breast. Post-operative specimens revealed encapsulated and well-circumscribed tumors with local invasion, necrosis, cytological atypia, and a high mitotic rate. In immunohistochemistry, coincidentally with the loose adhesion pattern of myoepithelial cells in both cases, the intensities of E-cadherin and beta-catenin were much weaker in myoepithelial than luminal epithelial cells, with almost negative finding of beta-catenin in one case. We first found deletion of CDH1 and polysomy of CEP16 in myoepithelial cells by double color-fluorescence in situ hybridization. The two cases have been followed up for 5-8 years, and both remained free from local recurrence and distant metastases. We also presented an overview of 47 cases of AME with carcinoma in English-language literatures.
authors.affiliation: Department of Pathology, Nihon University School of Medicine, Tokyo, Japan; Department of Pathology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, China. Electronic address: katherine_xu@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Respiratory Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iida
authors.affiliation: Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Fumi
authors.initials: F
authors.lastname: Fuchinoue
authors.affiliation: Department of Pathology, Aomori City Hospital, Aomori, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kusumi
authors.affiliation: Division of Pathology and Clinical Laboratory, Hirosaki National Hospital, Aomori, Japan.
authors.forename: Norito
authors.initials: N
authors.lastname: Yagihashi
authors.affiliation: Department of Pathology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
authors.forename: Kae
authors.initials: K
authors.lastname: Kawachi
authors.affiliation: Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Shimizu
authors.affiliation: Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Masuda
mesh_terms: D055331:Adenomyoepithelioma / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001943:Breast Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D015820:Cadherins / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D002885:Chromosomes, Human, Pair 16; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008408:Mastectomy; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D051176:beta Catenin / Q000032:analysis
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D051176:beta Catenin
keywords: Adenomyoepithelioma with carcinoma; Review; Tumor of the breast; WHO Classification