title: Spinal metastases: Is stereotactic body radiation therapy supported by evidences?
abstract: Stereotactic body radiotherapy (SBRT) is becoming widely adopted in the treatment of primary and secondary tumors. Spinal bone metastases are frequently discovered in cancer patients, and in the past have been usually treated with a palliative goal. Nevertheless, in some particular clinical settings, such as oligometastatic patients and/or those with a long life expectancy, spinal SBRT could be considered a valid therapeutic option to obtain long-lasting palliation and, when possible, with a curative goal. This review aims to summarize available clinical and dosimetric data of published studies about spinal SBRT.
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. Electronic address: berardino.de-bari@chuv.ch.
authors.forename: Berardino
authors.initials: B
authors.lastname: De Bari
authors.affiliation: Radiation Oncology Department, Sacro Cuore-Don Calabria Hospital, Negrar-Verona, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Alongi
authors.affiliation: Radiation Oncology Department, University of Palermo, Palermo,Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Mortellaro
authors.affiliation: Radiation Oncology Department, Sacro Cuore-Don Calabria Hospital, Negrar-Verona, Italy; Radiation Oncology Department, University of Palermo, Palermo,Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Mazzola
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
authors.forename: Luis
authors.initials: L
authors.lastname: Schiappacasse
authors.affiliation: Department for Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Guckenberger
mesh_terms: D001859:Bone Neoplasms / Q000453:epidemiology / Q000556:secondary / Q000601:surgery; D055317:Evidence-Based Practice / Q000592:standards / Q000706:statistics & numerical data; D050815:Fractures, Compression / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D006801:Humans; D010166:Palliative Care; D016634:Radiosurgery / Q000009:adverse effects / Q000706:statistics & numerical data; D011879:Radiotherapy Dosage; D016103:Spinal Fractures / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D013125:Spinal Neoplasms / Q000453:epidemiology / Q000556:secondary* / Q000601:surgery*; D016896:Treatment Outcome
keywords: Dosimetry; Local control; Palliative radiotherapy; SBRT; Spine metastases; Toxicity