title: Segregating attention from response control when performing a motor inhibition task: Segregating attention from response control.
abstract: Considerable work has demonstrated that inferior frontal gyrus (IFG), anterior insula cortex (AIC) and the supplementary motor area (SMA) are responsive during inhibitory control tasks. However, there is disagreement as to whether this relates to response selection/ inhibition or attentional processing. The current study investigates this by using a Go/No-go task with a factorial design. We observed that both left IFG and dorsal pre-SMA were responsive to no-go cues irrespective of cue frequency. This suggests a role for both in the inhibition of motor responses. Generalized psychophysiological interaction (gPPI) analyses suggest that inferior frontal gyrus may implement this function through interaction with basal ganglia and by suppressing the visual representation of cues associated with no-go responses. Anterior insula cortex and a more ventral portion of pre-SMA showed greater responsiveness to low frequency relative to higher frequency stimuli, irrespective of response type. This may reflect the hypothesized role of anterior insula cortex in marking low frequency items for additional processing (cf. Menon and Uddin, 2010). Consistent with this, the gPPI analysis revealed significantly greater anterior insula cortex connectivity with visual cortex in response to low relative to high frequency cues.
authors.affiliation: Section of Affective and Cognitive Neuroscience, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA. Electronic address: harma.meffert@nih.gov.
authors.forename: Harma
authors.initials: H
authors.lastname: Meffert
authors.affiliation: Section of Affective and Cognitive Neuroscience, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
authors.forename: Soonjo
authors.initials: S
authors.lastname: Hwang
authors.affiliation: Section of Affective and Cognitive Neuroscience, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
authors.forename: Zachary T
authors.initials: ZT
authors.lastname: Nolan
authors.affiliation: Scientific and Statistical Computing Core, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Section of Affective and Cognitive Neuroscience, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Blair
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D055815:Young Adult
keywords: Cognitive control; Generalized psychophysiological interactions; Go/No-go; fMRI