title: [Keratomycosis due to Fusarium oxysporum treated with the combination povidone iodine eye drops and oral fluconazole].
abstract: In developing countries where systemic antifungal are often unavailable, treatment of filamentous fungi infection as Fusarium is sometimes very difficult to treat. We report the case of a keratomycosis due to Fusarium oxysporum treated by povidone iodine eye drops and oral fluconazole. The diagnosis of abscess in the cornea was retained after ophthalmological examination for a 28-year-old man with no previous ophthalmological disease, addressed to the Ophthalmological clinic at the University Hospital Le Dantec in Dakar for a left painful red eye with decreased visual acuity lasting for 15 days. The patient did not receive any foreign body into the eye. Samples by corneal scraping were made for microbiological analysis and the patient was hospitalized and treated with a reinforced eye drops based treatment (ceftriaxone+gentamicin). The mycological diagnosis revealed the presence of a mold: F. oxysporum, which motivated the replacement of the initial treatment by eye drops containing iodized povidone solution at 1% because of the amphotericin B unavailability. Due to the threat of visual loss, oral fluconazole was added to the local treatment with eye drops povidone iodine. The outcome was favorable with a healing abscess and visual acuity amounted to 1/200th. Furthermore, we noted sequels such as pannus and pillowcase. The vulgarization of efficient topical antifungal in developing countries would be necessary to optimize fungal infection treatment.
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal. Electronic address: khadimase@gmail.com.
authors.forename: K
authors.initials: K
authors.lastname: Diongue
authors.affiliation: Clinique d'ophtalmologie, CHU Aristide Le Dantec, BP 5005, Dakar, Sénégal.
authors.forename: A S
authors.initials: AS
authors.lastname: Sow
authors.affiliation: Clinique d'ophtalmologie, CHU Aristide Le Dantec, BP 5005, Dakar, Sénégal.
authors.forename: M
authors.initials: M
authors.lastname: Nguer
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal; Laboratoire de parasitologie-mycologie, faculté de médecine, de pharmacie et d'odontologie de l'université Cheikh Anta Diop, BP 16477, Dakar, Sénégal.
authors.forename: M C
authors.initials: MC
authors.lastname: Seck
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal; Laboratoire de parasitologie-mycologie, faculté de médecine, de pharmacie et d'odontologie de l'université Cheikh Anta Diop, BP 16477, Dakar, Sénégal.
authors.forename: M
authors.initials: M
authors.lastname: Ndiaye
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal; Laboratoire de parasitologie-mycologie, faculté de médecine, de pharmacie et d'odontologie de l'université Cheikh Anta Diop, BP 16477, Dakar, Sénégal.
authors.forename: A S
authors.initials: AS
authors.lastname: Badiane
authors.affiliation: Clinique d'ophtalmologie, CHU Aristide Le Dantec, BP 5005, Dakar, Sénégal.
authors.forename: J M
authors.initials: JM
authors.lastname: Ndiaye
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal.
authors.forename: N W
authors.initials: NW
authors.lastname: Ndoye
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal.
authors.forename: M A
authors.initials: MA
authors.lastname: Diallo
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal; Clinique d'ophtalmologie, CHU Aristide Le Dantec, BP 5005, Dakar, Sénégal; Laboratoire de parasitologie-mycologie, faculté de médecine, de pharmacie et d'odontologie de l'université Cheikh Anta Diop, BP 16477, Dakar, Sénégal.
authors.forename: A
authors.initials: A
authors.lastname: Diop
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal.
authors.forename: Y D
authors.initials: YD
authors.lastname: Ndiaye
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal.
authors.forename: B
authors.initials: B
authors.lastname: Dieye
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal.
authors.forename: A
authors.initials: A
authors.lastname: Déme
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal.
authors.forename: I M
authors.initials: IM
authors.lastname: Ndiaye
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal; Laboratoire de parasitologie-mycologie, faculté de médecine, de pharmacie et d'odontologie de l'université Cheikh Anta Diop, BP 16477, Dakar, Sénégal.
authors.forename: O
authors.initials: O
authors.lastname: Ndir
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU Aristide Le Dantec, Dakar, Sénégal; Laboratoire de parasitologie-mycologie, faculté de médecine, de pharmacie et d'odontologie de l'université Cheikh Anta Diop, BP 16477, Dakar, Sénégal.
authors.forename: D
authors.initials: D
authors.lastname: Ndiaye
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D004359:Drug Therapy, Combination; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D015725:Fluconazole / Q000008:administration & dosage*; D005670:Fusarium / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D011206:Povidone-Iodine / Q000008:administration & dosage*
chemical_list: D009883:Ophthalmic Solutions; D011206:Povidone-Iodine; D015725:Fluconazole
keywords: Dantec; Fluconazole; Fungal keratitis; Fusarium oxysporum; Kératite fongique; Povidone iodine; Povidone iodée