title: Molecular basis of contact inhibition of locomotion.
abstract: Contact inhibition of locomotion (CIL) is a complex process, whereby cells undergoing a collision with another cell cease their migration towards the colliding cell. CIL has been identified in numerous cells during development including embryonic fibroblasts, neural crest cells and haemocytes and is the driving force behind a range of phenomenon including collective cell migration and dispersion. The loss of normal CIL behaviour towards healthy tissue has long been implicated in the invasion of cancer cells. CIL is a multi-step process that is driven by the tight coordination of molecular machinery. In this review, we shall breakdown CIL into distinct steps and highlight the key molecular mechanisms and components that are involved in driving each step of this process.
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
authors.forename: Alice
authors.initials: A
authors.lastname: Roycroft
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. r.mayor@ucl.ac.uk.
authors.forename: Roberto
authors.initials: R
authors.lastname: Mayor
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion; D002465:Cell Movement; D016764:Cell Polarity; D003260:Contact Inhibition; D006801:Humans; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D015820:Cadherins; D020741:rho GTP-Binding Proteins
keywords: Cadherin; Cell adhesion; Cell migration; Cell polarity; Rac; Rho