title: Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma.
abstract: CD70 upregulation by hypoxia-inducible factor and CD27+lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene(VHL)mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high soluble CD27 levels in the sera of ccRCC patients suggesting that soluble CD27 is a potential predictive tool for anti-CD70 therapy.
authors.affiliation: Institute of Surgical Pathology; University Hospital Zürich ; Zürich, Switzerland.
authors.forename: Melanie
authors.initials: M
authors.lastname: Ruf
authors.affiliation: Institute of Surgical Pathology; University Hospital Zürich ; Zürich, Switzerland.
authors.forename: Holger
authors.initials: H
authors.lastname: Moch
authors.affiliation: Institute of Surgical Pathology; University Hospital Zürich ; Zürich, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Schraml
keywords: CD27; CD70; clear cell renal cell carcinoma; soluble CD27; von Hippel-Lindau gene