title: Febrile Ulceronecrotic Mucha-Habermann Disease: Two Cases with Excellent Response to Methotrexate.
abstract: Febrile ulceronecrotic Mucha-Habermann disease (FUMHD), a severe form of pityriasis lichenoides et varioliformis acuta (PLEVA), featuring large, ulcerative, necrotic skin plaques, high fever, and other systemic symptoms, is a rare disorder of unknown etiology. No randomized controlled trials have established treatment guidelines and multiple modalities are often employed, making it difficult to assess the efficacy of any single agent. We report two cases of this condition in which treatment with methotrexate plus antibiotic treatment for superinfection led to rapid improvement.
authors.affiliation: Department of Dermatology, Center for Health and Healing, Oregon Health and Science University, Portland, Oregon.
authors.forename: Kelly
authors.initials: K
authors.lastname: Griffith-Bauer
authors.affiliation: Department of Dermatology, Center for Health and Healing, Oregon Health and Science University, Portland, Oregon.
authors.forename: Sabra L
authors.initials: SL
authors.lastname: Leitenberger
authors.affiliation: Department of Dermatology, Center for Health and Healing, Oregon Health and Science University, Portland, Oregon.
authors.forename: Alfons
authors.initials: A
authors.lastname: Krol
mesh_terms: D001707:Biopsy, Needle; D002506:Cephalexin / Q000008:administration & dosage; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005076:Exanthema / Q000175:diagnosis / Q000209:etiology; D005334:Fever / Q000175:diagnosis / Q000209:etiology; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000175:diagnosis* / Q000188:drug therapy*; D006760:Hospitalization; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D017514:Pityriasis Lichenoides / Q000175:diagnosis* / Q000188:drug therapy*; D035583:Rare Diseases; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D015163:Superinfection / Q000188:drug therapy / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D002506:Cephalexin; D008727:Methotrexate