title: The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia.
abstract: BACKGROUND
  Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG). We examined the role of the voltage-gated sodium channel subtype Nav1.9 in the development of trigeminal neuralgia.
  
  
  RESULTS
  We found that Nav1.9 is required for the development of both thermal and mechanical hypersensitivity induced by constriction of the infraorbital nerve (CION). The CION model does not induce change on Nav1.9 mRNA expression in the ipsilateral TG neurons when evaluated 9 days after surgery.
  
  
  CONCLUSIONS
  These results demonstrate that Nav1.9 channels play a critical role in the development of orofacial neuropathic pain. New routes for the treatment of orofacial neuropathic pain focussing on regulation of the voltage-gated Nav1.9 sodium channel activity should be investigated.
authors.affiliation: Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower St, London, WC1E 6BT, UK. a.luiz@ucl.ac.uk.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Luiz
authors.affiliation: Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower St, London, WC1E 6BT, UK. o.kopach@ucl.ac.uk.
authors.forename: Olga
authors.initials: O
authors.lastname: Kopach
authors.affiliation: Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower St, London, WC1E 6BT, UK. s.santana@ucl.ac.uk.
authors.forename: Sonia
authors.initials: S
authors.lastname: Santana-Varela
authors.affiliation: Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower St, London, WC1E 6BT, UK. j.wood@ucl.ac.uk.|Department of Molecular Medicine and Biopharmaceutical Sciences, College of Medicine, Seoul National University, Seoul, South Korea. j.wood@ucl.ac.uk.
authors.forename: John N
authors.initials: JN
authors.lastname: Wood
mesh_terms: D000818:Animals; D005157:Facial Pain / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006930:Hyperalgesia / Q000235:genetics / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009437:Neuralgia / Q000150:complications* / Q000503:physiopathology*; D014277:Trigeminal Neuralgia / Q000150:complications* / Q000503:physiopathology*