title: Recent developments in HLA-haploidentical transplantations.
abstract: While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area.
authors.affiliation: Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 289 Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21287, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Showel
authors.affiliation: Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 289 Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21287, USA. Electronic address: fuchsep@jhmi.edu.
authors.forename: Ephraim J
authors.initials: EJ
authors.lastname: Fuchs
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D019337:Hematologic Neoplasms / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D012008:Recurrence; D035781:Siblings; D016019:Survival Analysis; D019172:Transplantation Conditioning / Q000379:methods; D014185:Transplantation, Isogeneic; D061349:Unrelated Donors
chemical_list: D000970:Antineoplastic Agents; D003520:Cyclophosphamide
keywords: Acute myeloid leukemia; Cyclophosphamide; Graft versus host disease; HLA-haploidentical transplantation; Matched related donor; Matched unrelated donor; Mismatched unrelated donor; Relapse