title: Characterization of Electrograms from Multipolar Diagnostic Catheters during Atrial Fibrillation.
abstract: Atrial fibrillation (AF) is the most common arrhythmia in USA with more than 2.3 million people affected annually. Catheter ablation procedure is a method for treatment of AF, which involves 3D electroanatomic mapping of the patient's left atrium (LA) by maneuvering a conventional multipolar diagnostic catheter (MPDC) along the LA endocardial surface after which pulmonary vein (PV) isolation is performed, thus eliminating the AF triggers originating from the PVs. However, it remains unclear how to effectively utilize the information provided by the MPDC to locate the AF-sustaining sites, known as sustained rotor-like activities (RotAs). In this study, we use computer modeling to investigate the variations in the characteristics of the MPDC electrograms, namely, total conduction delay (TCD) and average cycle length (CL), as the MPDC moves towards a RotA source. Subsequently, a study with a human subject was performed in order to verify the predictions of the simulation study. The conclusions from this study may be used to iteratively direct an MPDC towards RotA sources thus allowing the RotAs to be localized for customized and improved AF ablation.
authors.affiliation: Biomedical Engineering Department, Rochester Institute of Technology, Rochester, NY 14623, USA.
authors.forename: Prasanth
authors.initials: P
authors.lastname: Ganesan
authors.affiliation: School of Mathematical Sciences, Rochester Institute of Technology, Rochester, NY 14623, USA.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Cherry
authors.affiliation: Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
authors.forename: Arkady M
authors.initials: AM
authors.lastname: Pertsov
authors.affiliation: Biomedical Engineering Department, Rochester Institute of Technology, Rochester, NY 14623, USA.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Ghoraani
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D062906:Cardiac Catheters; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000503:physiopathology; D017115:Catheter Ablation / Q000379:methods; D003198:Computer Simulation; D003935:Diagnostic Techniques, Cardiovascular; D022062:Electrophysiologic Techniques, Cardiac; D004699:Endocardium / Q000503:physiopathology; D006325:Heart Atria / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular; D016896:Treatment Outcome