title: Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A.
abstract: The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: X-D
authors.initials: XD
authors.lastname: Gong
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Huang
authors.forename: Q
authors.initials: Q
authors.lastname: Nie
authors.forename: Z-F
authors.initials: ZF
authors.lastname: Wang
authors.forename: W-K
authors.initials: WK
authors.lastname: Ji
authors.forename: X-H
authors.initials: XH
authors.lastname: Hu
authors.forename: W-F
authors.initials: WF
authors.lastname: Hu
authors.forename: L-L
authors.initials: LL
authors.lastname: Gong
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: R-L
authors.initials: RL
authors.lastname: Qi
authors.forename: T-H
authors.initials: TH
authors.lastname: Yang
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Chen
authors.forename: W-B
authors.initials: WB
authors.lastname: Liu
authors.forename: Y-Z
authors.initials: YZ
authors.lastname: Liu
authors.affiliation: Key Laboratory of Protein Chemistry and Developmental Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China. dwli1688@hotmail.com.
authors.forename: D W-C
authors.initials: DW
authors.lastname: Li
mesh_terms: D000818:Animals; D017209:Apoptosis; D002386:Cataract / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005123:Eye / Q000254:growth & development / Q000378:metabolism*; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005901:Glaucoma / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D006054:Goldfish; D000076249:Heat Shock Transcription Factors; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D038081:Organogenesis / Q000235:genetics; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000235:genetics / Q000378:metabolism; D054645:Protein Phosphatase 1 / Q000235:genetics* / Q000378:metabolism; D054648:Protein Phosphatase 2 / Q000235:genetics* / Q000378:metabolism; D021122:Protein Subunits / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D005136:Eye Proteins; C102948:HSF4 protein, human; D000076249:Heat Shock Transcription Factors; D018398:Homeodomain Proteins; D007527:Isoenzymes; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D021122:Protein Subunits; D012097:Repressor Proteins; D014157:Transcription Factors; D054645:Protein Phosphatase 1; D054648:Protein Phosphatase 2