title: DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture.
abstract: Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis. The aim of the present study was to evaluate the significance of polymorphism Lys939Gln in XPC gene in patients with mitral chordae tendinea rupture (MCTR). Twenty-one patients with MCTR and thirty-seven age and sex matched controls were enrolled in the study. Genotyping of XPC gene Lys939Gln polymorphism was carried out using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP). The frequencies of the heterozygote genotype (Lys/Gln-AC) and homozygote genotype (Gln/Gln-CC) were significantly different in MCTR as compared to control group, respectively (52.4% versus 43.2%, p = 0.049; 38.15% versus 16.2%, p = 0.018). Homozygote variant (Gln/Gln) genotype was significantly associated with increased risk of MCTR (OR = 2.059; 95% CI: 1.097-3.863; p = 0.018). Heterozygote variant (Lys/Gln) genotype was also highly significantly associated with increased risk of MCTR (OR = 1.489; 95% CI: 1.041-2.129; p = 0.049). The variant allele C was found to be significantly associated with MCTR (OR = 1.481; 95% CI: 1.101-1.992; p = 0.011). This study has demonstrated the association of XPC gene Lys939Gln polymorphism with MCTR, which is significantly associated with increased risk of MCTR.
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
authors.forename: Aysel Kalayci
authors.initials: AK
authors.lastname: Yigin
authors.affiliation: Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
authors.forename: Mehmet Bulent
authors.initials: MB
authors.lastname: Vatan
authors.affiliation: Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
authors.affiliation: Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
authors.forename: Muhammed Necati Murat
authors.initials: MN
authors.lastname: Aksoy
authors.affiliation: Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Cakar
authors.affiliation: Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Kilic
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
authors.forename: Unal
authors.initials: U
authors.lastname: Erkorkmaz
authors.affiliation: Department of Anatomy, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
authors.forename: Keziban
authors.initials: K
authors.lastname: Karacan
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Kaleli
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002815:Chordae Tendineae / Q000473:pathology*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006349:Heart Valve Diseases / Q000235:genetics* / Q000473:pathology; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology*; D020641:Polymorphism, Single Nucleotide
chemical_list: D004268:DNA-Binding Proteins; C086984:XPC protein, human