title: Carbamoyl anion-initiated cascade reaction for stereoselective synthesis of substituted α-hydroxy-β-amino amides.
abstract: A carbamoyl anion-initiated cascade reaction with acylsilanes and imines has been used to rapidly construct substituted α-hydroxy-β-amino amides. The Brook rearrangement-mediated cascade allows the formation of two C-C bonds and one O-Si bond in a single pot. Using this approach, a range of α-aryl α-hydroxy-β-amino amides has been synthesized in high yields with excellent diastereoselectivities.
authors.affiliation: The Key Laboratory of Plant Resources and Chemistry of Arid Zones, Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. clu@ms.xjb.ac.cn xuyj@ms.xjb.ac.cn.
authors.forename: Chao-Yang
authors.initials: CY
authors.lastname: Lin
authors.affiliation: The Key Laboratory of Plant Resources and Chemistry of Arid Zones, Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. clu@ms.xjb.ac.cn xuyj@ms.xjb.ac.cn.
authors.forename: Peng-Ju
authors.initials: PJ
authors.lastname: Ma
authors.affiliation: Department of Chemistry and Applied Chemistry, Changji University, Changji 831100, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Sun
authors.affiliation: The Key Laboratory of Plant Resources and Chemistry of Arid Zones, Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. clu@ms.xjb.ac.cn xuyj@ms.xjb.ac.cn and Department of Chemistry and Applied Chemistry, Changji University, Changji 831100, China.
authors.forename: Chong-Dao
authors.initials: CD
authors.lastname: Lu
authors.affiliation: The Key Laboratory of Plant Resources and Chemistry of Arid Zones, Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. clu@ms.xjb.ac.cn xuyj@ms.xjb.ac.cn.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Xu
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000838:Anions