title: Adipokines, diabetes and atherosclerosis: an inflammatory association.
abstract: Cardiovascular diseases can be considered the most important cause of death in diabetic population and diabetes can in turn increase the risk of cardiovascular events. Inflammation process is currently recognized as responsible for the development and maintenance of diverse chronic diseases, including diabetes and atherosclerosis. Considering that adipose tissue is an important source of adipokines, which may present anti and proinflammatory effects, the aim of this review is to explore the role of the main adipokines in the pathophysiology of diabetes and atherosclerosis, highlighting the therapeutic options that could arise from the manipulation of these signaling pathways both in humans and in translational models.
authors.affiliation: Biological Sciences Institute, Federal University of Minas Gerais Belo Horizonte, Brazil.
authors.forename: Leandro C
authors.initials: LC
authors.lastname: Freitas Lima
authors.affiliation: Biotechnology Center, Federal University of Paraiba (Universidade Federal da Paraíba) Joao Pessoa, Brazil.
authors.forename: Valdir de Andrade
authors.initials: VA
authors.lastname: Braga
authors.affiliation: Biotechnology Center, Federal University of Paraiba (Universidade Federal da Paraíba) Joao Pessoa, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: do Socorro de França Silva
authors.affiliation: Biotechnology Center, Federal University of Paraiba (Universidade Federal da Paraíba) Joao Pessoa, Brazil.
authors.forename: Josiane de Campos
authors.initials: JC
authors.lastname: Cruz
authors.affiliation: Biological Sciences Institute, Federal University of Minas Gerais Belo Horizonte, Brazil ; Health Science Post-Graduate Program, State University of Montes Claros Montes Claros, Brazil.
authors.forename: Sérgio H
authors.initials: SH
authors.lastname: Sousa Santos
authors.affiliation: Biotechnology Center, Federal University of Paraiba (Universidade Federal da Paraíba) Joao Pessoa, Brazil.
authors.forename: Matheus M
authors.initials: MM
authors.lastname: de Oliveira Monteiro
authors.affiliation: Biotechnology Center, Federal University of Paraiba (Universidade Federal da Paraíba) Joao Pessoa, Brazil ; Health Sciences Center, Federal University of Paraiba (Universidade Federal da Paraíba) Joao Pessoa, Brazil.
authors.forename: Camille de Moura
authors.initials: CM
authors.lastname: Balarini
keywords: IL-6; MCP-1; TNFα; adipokines; adiponectin; atherosclerosis; diabetes; leptin