title: Lung specific X protein as a novel therapeutic target for lung cancer.
abstract: The identification of novel therapeutic targets in lung cancer is an urgent challenge. We found lung-specific X protein (LunX) is overexpressed in lung cancer and promotes primary tumor growth and metastatic colonization. The antibody against LunX appears to be potentially applicable for therapeutic use in the future, given its efficacy in preclinical models.
authors.affiliation: Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease; School of Life Science and Medical Center; University of Science and Technology of China ; Hefei, China ; Hefei National Laboratory for Physical Sciences at Microscale; University of Science and Technology of China ; Hefei, China.
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease; School of Life Science and Medical Center; University of Science and Technology of China ; Hefei, China ; Hefei National Laboratory for Physical Sciences at Microscale; University of Science and Technology of China ; Hefei, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Tian
authors.affiliation: Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease; School of Life Science and Medical Center; University of Science and Technology of China ; Hefei, China ; Hefei National Laboratory for Physical Sciences at Microscale; University of Science and Technology of China ; Hefei, China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Wei
keywords: 14–3–3; LunX; antibody therapy; non-small-cell lung cancer; tumor growth and metastasis