title: Fish oil improves lipid profile in juvenile rats with intrauterine growth retardation by altering the transcriptional expression of lipid-related hepatic genes.
abstract: OBJECTIVE
  To determine whether maternal intrauterine undernutrition and post-weaning fish oil intake influence lipid profile in juvenile offspring, and explore the possible mechanisms at transcriptional levels.
  
  
  METHODS
  After weaning, 32 control offspring and 24 intrauterine growth retardation (IUGR) offspring were randomly allocated to standard chow or fish oil diet. At 10 weeks, fasting plasma glucose, triglycerides, total cholesterol and expressions of related hepatic genes were examined.
  
  
  RESULTS
  IUGR offspring without catch-up growth tended to develop hyperglycemia, dyslipidemia and hepatic steatosis. Down-regulation of CPT-1 and LDLR at transcriptional levels were found in IUGR offspring. Early short-term fish oil intervention reversed these unfavorable changes in juvenile rats with IUGR. The mechanisms might be mediated by decreased expression of ACC-1, increased expression of CPT-1, LDLR and ABCG5.
  
  
  CONCLUSIONS
  These data suggest that IUGR offspring already present lipid abnormality in juvenile stage, and early short-term fish oil consumption is beneficial to prevent these unfavorable changes.
authors.affiliation: a Department of Pediatrics , The First Affiliated Hospital of College of Medicine, Zhejiang University , Hangzhou , Zhejiang , China and.|b Department of Pediatrics , The Second Affiliated Hospital of Fujian Medical University , Quanzhou , Fujian , China.
authors.forename: Lian-Hui
authors.initials: LH
authors.lastname: Chen
authors.affiliation: a Department of Pediatrics , The First Affiliated Hospital of College of Medicine, Zhejiang University , Hangzhou , Zhejiang , China and.
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.affiliation: a Department of Pediatrics , The First Affiliated Hospital of College of Medicine, Zhejiang University , Hangzhou , Zhejiang , China and.
authors.forename: Yan-Lan
authors.initials: YL
authors.lastname: Fang
authors.affiliation: a Department of Pediatrics , The First Affiliated Hospital of College of Medicine, Zhejiang University , Hangzhou , Zhejiang , China and.
authors.forename: Ying-Min
authors.initials: YM
authors.lastname: Wang
authors.affiliation: a Department of Pediatrics , The First Affiliated Hospital of College of Medicine, Zhejiang University , Hangzhou , Zhejiang , China and.
authors.forename: Wei-Fen
authors.initials: WF
authors.lastname: Zhu
mesh_terms: D000818:Animals; D004435:Eating; D005260:Female; D005317:Fetal Growth Retardation / Q000178:diet therapy*; D005395:Fish Oils / Q000627:therapeutic use*; D015870:Gene Expression; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D009929:Organ Size; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D015430:Weight Gain
chemical_list: D005395:Fish Oils; D008055:Lipids
keywords: Fish oil; hyperlipidemia; intrauterine growth retardation; lipid metabolism disorders; non-alcoholic fatty liver disease