title: Role of Exosomal Noncoding RNAs in Lung Carcinogenesis.
abstract: Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology.
authors.affiliation: Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.affiliation: Department of Perinatal Medicine, Pregnancy Research Centre and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors.forename: Bill
authors.initials: B
authors.lastname: Kalionis
authors.affiliation: Emergency Department of Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430010, China.
authors.forename: Guoying
authors.initials: G
authors.lastname: Lv
authors.affiliation: Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Shijin
authors.initials: S
authors.lastname: Xia
authors.affiliation: Department of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D055354:Exosomes / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D022661:RNA, Untranslated / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated