title: Case report: Concomitant Chronic Lymphocytic Leukaemia and Cytogenetically Normal de novo Acute Leukaemia in a Patient.
abstract: The simultaneous occurrence of acute myeloid leukaemia with untreated chronic lymphocytic leukemia is extremely rare. We report a case of a 74-year-old man who was evaluated for macrocytic anaemia. Based on the morphology and immunophenotyping analysis of peripheral blood, a diagnosis of chronic lymphocytic leukemia was established. Subsequently, the bone marrow examination revealed the presence of two distinct, coexisting CLL and AML clones. Cytogenetic and molecular genetic analysis detected deletion 13q14.3 and unmutated immunoglobulin variable heavy-chain in the CLL clone, only. The AML and CLL clones did not share clonality, and the AML did not involve the peripheral blood. A diagnosis of cytogenetically normal de novo AML occurring concurrently with untreated CLL has not been reported previously in English literature.
authors.affiliation: Pécs University, Faculty of Medicine, Department of Pathology, Pécs-Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Kajtár
authors.affiliation: Kaposi Mór Teaching Hospital in affilation with Pécs University, Department of Haematology, Kaposvár-Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Rajnics
authors.affiliation: Kaposi Mór Teaching Hospital in affilation with Pécs University, Department of Haematology, Kaposvár-Hungary.
authors.forename: Miklós
authors.initials: M
authors.lastname: Egyed
authors.affiliation: Kaposi Mór Teaching Hospital in affilation with Pécs University, Department of Haematology, Kaposvár-Hungary Pécs University, Faculty of Medicine, 1st. Department of Internal Medicine, Division of Haematology and Haematopoietic Stem Cell Transplantation, Pécs-Hungary alizadeh.hussain@gmail.com.
authors.forename: Hussain
authors.initials: H
authors.lastname: Alizadeh
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13; D020732:Cytogenetic Analysis; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male
chemical_list: D007143:Immunoglobulin Heavy Chains
keywords: Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Concomitant; Cytogenetic