title: Correspondence between Resting-State Activity and Brain Gene Expression.
abstract: The relationship between functional brain activity and gene expression has not been fully explored in the human brain. Here, we identify significant correlations between gene expression in the brain and functional activity by comparing fractional amplitude of low-frequency fluctuations (fALFF) from two independent human fMRI resting-state datasets to regional cortical gene expression from a newly generated RNA-seq dataset and two additional gene expression datasets to obtain robust and reproducible correlations. We find significantly more genes correlated with fALFF than expected by chance and identify specific genes correlated with the imaging signals in multiple expression datasets in the default mode network. Together, these data support a population-level relationship between regional steady-state brain gene expression and resting-state brain activity.
authors.affiliation: Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Guang-Zhong
authors.initials: GZ
authors.lastname: Wang
authors.affiliation: Program in Neurobehavioral Genetics, Center for Autism Treatment and Research, Semel Institute, Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: T Grant
authors.initials: TG
authors.lastname: Belgard
authors.affiliation: Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Deng
authors.initials: D
authors.lastname: Mao
authors.affiliation: Department of Human Genetics, Center for Autism Treatment and Research, Semel Institute, Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Leslie
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Stefano
authors.initials: S
authors.lastname: Berto
authors.affiliation: Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, and Department of Pathology, Emory University School of Medicine, Atlanta, GA 30329, USA.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Preuss
authors.affiliation: Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX 75390, USA; Departments of Psychiatry and Radiology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Hanzhang
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Human Genetics, Center for Autism Treatment and Research, Semel Institute, Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: dhg@ucla.edu.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Geschwind
authors.affiliation: Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: genevieve.konopka@utsouthwestern.edu.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Konopka
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D005260:Female; D059907:Functional Neuroimaging; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019579:Neocortex / Q000378:metabolism; D009434:Neural Pathways / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism*; D017423:Sequence Analysis, RNA
chemical_list: D012333:RNA, Messenger