title: Risk of Advanced Adenomas in Siblings of Individuals With Advanced Adenomas: A Cross-Sectional Study.
abstract: OBJECTIVE
  The risk of colorectal neoplasms among siblings of patients with advanced adenomas is not clear. We determined the prevalence of advanced adenomas in the siblings of patients with advanced adenomas and compared it with that of siblings of individuals without these lesions.
  
  
  METHODS
  In a blinded, cross-sectional study, colonoscopies were performed (from 2010 through 2014), at 2 hospitals in Hong Kong on 200 asymptomatic siblings of patients with advanced adenomas (exposed; mean age, 58.2 ± 6.3 years; adenomas ≥10 mm, high-grade dysplasia, villous, or tubulovillous) and 400 age- and sex-matched siblings of subjects with normal findings from colonoscopies and no family history of colorectal cancer (unexposed; mean age, 58.1 ± 6 years). We recruited 1 sibling per family. The primary outcome was prevalence of advanced adenomas.
  
  
  RESULTS
  Baseline demographics (ie, aspirin use, smoking, body mass index, and metabolic diseases) did not differ significantly between exposed and unexposed individuals. The prevalence of advanced adenoma was 11.5% among the exposed subjects and 2.5% among the unexposed subjects (matched odds ratio [mOR] = 6.05; 95% confidence interval [CI]: 2.74-13.36; P < .001). The prevalence of adenomas ≥10 mm was higher among exposed than unexposed siblings (10.5% vs 1.8%; mOR = 8.59; 95% CI: 3.44-21.45; P < .001), as was the prevalence of villous adenomas (5.5% vs 1.3% in unexposed; mOR = 6.28; 95% CI: 2.02-19.53; P = .001) and all colorectal adenomas (39.0% vs 19.0% in unexposed; mOR = 3.29; 95% CI: 2.16-5.03; P < .001). Two cancers were detected in exposed siblings and none in unexposed siblings.
  
  
  CONCLUSIONS
  In a cross-sectional study of subjects undergoing colonoscopy in Hong Kong, siblings of individuals with at least 1 advanced adenoma had a 6-fold increased odds of advanced adenoma compared with subjects who had a sibling with a screening colonoscopy with no identified neoplasia. ClinicalTrials.gov, Number: NCT01593098.
authors.affiliation: Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong.
authors.forename: Siew C
authors.initials: SC
authors.lastname: Ng
authors.affiliation: Department of Surgery, Chinese University of Hong Kong, Hong Kong. Electronic address: laujyw@surgery.cuhk.edu.hk.
authors.forename: James Y W
authors.initials: JY
authors.lastname: Lau
authors.affiliation: Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong.
authors.forename: Francis K L
authors.initials: FK
authors.lastname: Chan
authors.affiliation: Department of Surgery, Chinese University of Hong Kong, Hong Kong.
authors.forename: Bing Yee
authors.initials: BY
authors.lastname: Suen
authors.affiliation: Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong.
authors.forename: Yee Kit
authors.initials: YK
authors.lastname: Tse
authors.affiliation: Department of Gastroenterology, Alice Ho Miu-Ling Nethersole Hospital, Hong Kong.
authors.forename: Aric J
authors.initials: AJ
authors.lastname: Hui
authors.affiliation: Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong.
authors.forename: En Ling
authors.initials: EL
authors.lastname: Leung-Ki
authors.affiliation: Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong.
authors.forename: Jessica Y L
authors.initials: JY
authors.lastname: Ching
authors.affiliation: Department of Anatomy Chemical Pathology, Chinese University of Hong Kong, Hong Kong.
authors.forename: Anthony W H
authors.initials: AW
authors.lastname: Chan
authors.affiliation: School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: Martin C S
authors.initials: MC
authors.lastname: Wong
authors.affiliation: Department of Surgery, Chinese University of Hong Kong, Hong Kong.
authors.forename: Simon S M
authors.initials: SS
authors.lastname: Ng
authors.affiliation: Department of Anatomy Chemical Pathology, Chinese University of Hong Kong, Hong Kong.
authors.forename: Ka Fai
authors.initials: KF
authors.lastname: To
authors.affiliation: Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong.
authors.forename: Justin C Y
authors.initials: JC
authors.lastname: Wu
authors.affiliation: Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong.
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D016017:Odds Ratio; D010375:Pedigree; D010641:Phenotype; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D035781:Siblings; D047368:Tumor Burden
keywords: Colon Cancer; Early Detection; Prevention; Risk Factor