title: Loco-regional administration of nanomedicines for the treatment of lung cancer.
abstract: Lung cancer poses one of the most significant challenges to modern medicine, killing thousands every year. Current therapy involves surgical resection supplemented with chemotherapy and radiotherapy due to high rates of relapse. Shortcomings of currently available chemotherapy protocols include unacceptably high levels of systemic toxicity and low accumulation of drug at the tumor site. Loco-regional delivery of nanocarriers loaded with anticancer agents has the potential to significantly increase efficacy, while minimizing systemic toxicity to anticancer agents. Local drug administration at the tumor site using nanoparticulate drug delivery systems can reduce systemic toxicities observed with intravenously administered anticancer drugs. In addition, this approach presents an opportunity for sustained delivery of anticancer drug over an extended period of time. Herein, the progress in the development of locally administered nanomedicines for the treatment of lung cancer is reviewed. Administration by inhalation, intratumoral injection and means of direct in situ application are discussed, the benefits and drawbacks of each modality are explored.
authors.affiliation: a Graduate School of Health, University of Technology Sydney , Sydney , Australia and.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Garrastazu Pereira
authors.affiliation: a Graduate School of Health, University of Technology Sydney , Sydney , Australia and.
authors.forename: Amanda Jane
authors.initials: AJ
authors.lastname: Lawson
authors.affiliation: b Department of Pharmacy , University of Parma , Parma , Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Buttini
authors.affiliation: b Department of Pharmacy , University of Parma , Parma , Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Sonvico
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations
keywords: Chemotherapy; inhalation; local drug delivery; lung cancer; nanomedicine