title: Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients.
abstract: We investigated the influence of the age-of-onset (AO) on the association of 45 loci conferring risk for bipolar disorder (BP) and schizophrenia with BP-type-I in a Romanian sample (461 patients, 436 controls). The AO-analysis implicated the EGFR gene, as well as loci in other genes, in the AO variation of BP-type-I and revealed for the first time the link between BP-type-I and risk variants considered specific to schizophrenia (polymorphisms in MMP16/RIPK2 and CNNM2 genes).
authors.affiliation: Alexandru Obregia Clinical Psychiatric Hospital, Biometric Psychiatric Genetics Research Unit, Bucharest, Romania. Electronic address: maria.serbanescu@googlemail.com.
authors.forename: Maria
authors.initials: M
authors.lastname: Grigoroiu-Serbanescu
authors.affiliation: Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
authors.forename: Carmen C
authors.initials: CC
authors.lastname: Diaconu
authors.affiliation: Institute of Human Genetics, Dept. Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Heilmann-Heimbach
authors.affiliation: Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
authors.forename: Ana Iulia
authors.initials: AI
authors.lastname: Neagu
authors.affiliation: Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, D-17475 Greifswald, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Becker
mesh_terms: D000328:Adult; D017668:Age of Onset; D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012383:Romania; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
keywords: CNNM2 genes; EGFR; MMP16