title: Efficacy of lifestyle interventions on clinical and neuroimaging outcomes in elderly.
abstract: The prevalence of Alzheimer's disease (AD) is constantly growing worldwide in absence of any effective treatment. Methodology and technique advancements facilitated the early diagnosis of AD leading to a shift toward preclinical AD stages investigation in order to delay the disease onset in individuals at risk for AD. Recent evidence demonstrating the aging related multifactorial nature of AD supported the hypothesis that modifiable environmental factors can accelerate or delay the disease onset. In particular, healthy dietary habits, constant physical and cognitive activities are associated with reduced brain atrophy, amyloid load and incidence of AD cases. Due to these promising results, an emerging field of studies is currently investigating the efficacy of interventions addressing different lifestyle habits in cognitive intact elderly individuals as a potential preventive strategy against AD onset. We provide a critical overview of the current evidence on nonpharmacologic treatments in elderly individuals, discussing their efficacy on clinical and neuroimaging outcomes and identifying current methodological issues. Future perspectives, relevant for the scientific community and the worldwide public health institutes will be further discussed.
authors.affiliation: Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. Electronic address: erolandi@fatebenefratelli.eu.
authors.forename: Elena
authors.initials: E
authors.lastname: Rolandi
authors.affiliation: Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and Laboratory of Neuroimaging of Ageing - LANVIE, University Hospitals and University of Geneva, Geneva, Switzerland. Electronic address: giovanni.frisoni@gmail.com.
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Frisoni
authors.affiliation: Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Sorbonne Universités, Université Pierre et Marie Curie (UPMC), Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), UMR S 1127, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, 75013 Paris, France and the CATI multicenter neuroimaging platform (cati-neuroimaging.com), France. Electronic address: enrica.cavedo@gmail.com.
authors.forename: Enrica
authors.initials: E
authors.lastname: Cavedo
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology* / Q000517:prevention & control*; D006801:Humans; D008019:Life Style; D059906:Neuroimaging / Q000379:methods*
keywords: Alzheimer’s disease; Clinical outcomes; Lifestyle; Neuroimaging; Nonpharmacological interventions; Prevention trials