title: Novel crown-ether-methylenediphosphonotetrathioate hybrids as Zn(II) chelators.
abstract: Hybrids of methylenediphosphonotetrathioate and crown-ether (MDPT-CE) were synthesized forming 7-,8-,9-,10- and 13-membered rings. Both 7- and 13-membered ring-containing compounds were found to be highly stable to air-oxidation for at least four weeks. These hybrids bind Zn(II) by both MDPT and CE moieties, forming a 2 : 1 L : Zn(II) complex. Interestingly, the 13-membered ring MDPT-CE showing a high affinity to Zn(II) (Ka 3 ± 0.5 × 10(6) mol(-2) L(2)) does not bind Li(I) or Na(I). The 13-Membered MDPT-CE hybrid is a promising water-soluble, air-stable, high-affinity Zn(II)-chelator, exhibiting selectivity to Zn(II) vs. Mg(II), Na(I), and Li(I).
authors.affiliation: Department of Chemistry, Bar Ilan University, Ramat Gan, 52900, Israel. bilha.fischer@biu.ac.il.
authors.forename: Diana
authors.initials: D
authors.lastname: Meltzer
authors.forename: Hugo E
authors.initials: HE
authors.lastname: Gottlieb
authors.forename: Aviran
authors.initials: A
authors.lastname: Amir
authors.forename: Linda J W
authors.initials: LJ
authors.lastname: Shimon
authors.forename: Bilha
authors.initials: B
authors.lastname: Fischer