title: [OPTIMIZATION OF BRONCHODILATOR THERAPY FOR CHILDREN DURING ASTHMA EXACERBATION WITH ALLOWANCE FOR THE RISK OF DEVELOPMENT OF CARDIOHEMODYNAMIC DISORDERS].
abstract: We have studied the effect of bronchodilator drugs representing three groups--b2-adrenomimetic (fenoterol), anticholinergic (ipratropium bromide), and combined preparation (fenoterol/ipratropium bromide)--on cardiohemodynamics in children with acute asthma exacerbation. It is established that incorrect choice of bronchodilator most significantly influences the parameters of blood pressure and blood flow rate in the pulmonary artery, mitral and tricuspid valves, and also contributes to the appearance of signs of diastolic dysfunction of the right and left ventricles. A model predicting the risk of cardiohemodynamic violations was created using the multiple regression method, which allows the probability of negative changes in the cardiovascular system on the background of bronchodilator therapy to be calculated within several minutes using data on the medical prehistory and the results of objective and instrumental examination of a patient. Using this model it is possible to optimize the bronchodilator treatment of acute asthma in children and also to prevent the formation of future complications of the cardiovascular system.
authors.forename: A
authors.initials: A
authors.lastname: Lebedenko
authors.forename: O
authors.initials: O
authors.lastname: Semernik
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000503:physiopathology*; D011651:Pulmonary Artery / Q000503:physiopathology*; D014261:Tricuspid Valve / Q000503:physiopathology*
chemical_list: D001993:Bronchodilator Agents