title: Cyanobactins from Cyanobacteria: Current Genetic and Chemical State of Knowledge.
abstract: Cyanobacteria are considered to be one of the most promising sources of new, natural products. Apart from non-ribosomal peptides and polyketides, ribosomally synthesized and post-translationally modified peptides (RiPPs) are one of the leading groups of bioactive compounds produced by cyanobacteria. Among these, cyanobactins have sparked attention due to their interesting bioactivities and for their potential to be prospective candidates in the development of drugs. It is assumed that the primary source of cyanobactins is cyanobacteria, although these compounds have also been isolated from marine animals such as ascidians, sponges and mollusks. The aim of this review is to update the current knowledge of cyanobactins, recognized as being produced by cyanobacteria, and to emphasize their genetic clusters and chemical structures as well as their bioactivities, ecological roles and biotechnological potential.
authors.affiliation: Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto 4169-007, Portugal. joana.o.martins@gmail.com.|Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, Porto 4050-123, Portugal. joana.o.martins@gmail.com.
authors.forename: Joana
authors.initials: J
authors.lastname: Martins
authors.affiliation: Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto 4169-007, Portugal. vmvascon@fc.up.pt.|Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, Porto 4050-123, Portugal. vmvascon@fc.up.pt.
authors.forename: Vitor
authors.initials: V
authors.lastname: Vasconcelos
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000302:isolation & purification*; D001709:Biotechnology / Q000379:methods; D000458:Cyanobacteria / Q000235:genetics / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D005810:Multigene Family; D011499:Protein Processing, Post-Translational
chemical_list: D001426:Bacterial Proteins
keywords: bioactivities; biotechnological potential; chemical structures; cyanobacteria; cyanobactins; ecological roles; genetic clusters