title: [Treatment of Proteinuria in Chronic Glomerular Disease Patients with Pi-Shen Deficiency Complicated Damp-Heat Syndrome by Yishen Qingre Huashi Recipe: a Clinical Study].
abstract: OBJECTIVE
  To observe the therapeutic effect of Yishen Qingre Huashi Recipe (YQHR) in treating proteinuria of chronic glomerular disease patients with Pi-Shen deficiency complicated damp-heat syndrome (PSDCDHS).
  
  
  METHODS
  Totally 121 stage 1 -2 primary chronic glomerular disease patients with PSDCDHS were randomly assigned to the treated group (85 cases) and the control group (36 cases) according to 2:1. All patients received conventional and symptomatic treatment. Patients in the treated group took YQHR additionally, while those in the control group took Losartan Potassium Tablet (50 mg each time, once per day) additionally. The therapeutic course for all was 6 months. Changes of 24 h urine protein, blood urea nitrogen (BUN), serum creatinine(SCr), and estimated glomerular filtration rate (eGFR) were observed at different time points. And the difference in therapeutic effects were compared between the two groups.
  
  
  RESULTS
  Compared with the control group after 6 months of treatment, 24 h urine protein obviously decreased in the treated group (P <0. 05). There was no statistical difference in SCr, BUN, or eGFR between the two groups after 6 months of treatment (P >0. 05). The total effective rate after 2, 4, and 6 months of treatment in the treated group was 77. 6% (66/85 cases), 82. 4% (70/85 cases), and 89. 4% (76/85 cases), respectively. They were 47. 2% (17/36 cases), 55. 6% (20/36 cases), and 61. 1% (22/36 cases) in the control group, respectively. Compared with before treatment in the treated group, the total effective effect after 6 months of treatment was higher than that after 2 months of treatment (χ2=4. 28, P <0. 01). Compared with the control group at the same time points, the total effective rate in the treated group after 2, 4, and 6 months of treatment was higher (χ2=10. 87, 9. 53, 13.16, P <0. 01).
  
  
  CONCLUSIONS
  YQHR could significantly lower proteinuria in chronic glomerular disease patients with PSDCDHS, improve the clinical effect, thereby providing clinical evidence for treating chronic glomerular disease proteinuria from resolving dampness and clearing heat.
authors.forename: Qin
authors.initials: Q
authors.lastname: Dai
authors.forename: Pei-qing
authors.initials: PQ
authors.lastname: Zhang
authors.forename: Xiao-qin
authors.initials: XQ
authors.lastname: Wang
authors.forename: Li-fang
authors.initials: LF
authors.lastname: Nie
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Fu
authors.forename: Wen
authors.initials: W
authors.lastname: Peng
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Yue-ping
authors.initials: YP
authors.lastname: Bi
authors.forename: Xiu-hua
authors.initials: XH
authors.lastname: Mi
authors.forename: Min
authors.initials: M
authors.lastname: Yuan
authors.forename: Li-qun
authors.initials: LQ
authors.lastname: He
mesh_terms: D001806:Blood Urea Nitrogen; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006358:Hot Temperature; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000628:therapy; D007678:Kidney Glomerulus / Q000473:pathology*; D019808:Losartan; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D011507:Proteinuria / Q000209:etiology / Q000628:therapy*; D013577:Syndrome; D013607:Tablets
chemical_list: D004365:Drugs, Chinese Herbal; D013607:Tablets; C525740:yishen; D019808:Losartan