title: Interleukin-10 production at the early stage of infection with foot-and-mouth disease virus related to the likelihood of persistent infection in cattle.
abstract: The factors leading to persistent infection of foot-and-mouth disease (FMD) virus in ruminants are not well defined. This paper provides evidence of the presence of interleukin-10 (IL-10) early in the course of infection (1-4 days) as a factor in the development of persistence of FMD virus in cattle. Results showed that serum IL-10 in carrier cattle infected with FMD virus type O (n = 4) was detected and peaked at 1 or 2 days post infection and rapidly declined thereafter. In contract, serum IL-10 levels in non-carrier cattle (n = 21) were very low or undetectable during the same period.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Xujiaping 1, Lanzhou, 730046, Gansu, China. zhangzhidong@caas.cn.|The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, GU24 0NF, UK. zhangzhidong@caas.cn.
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, GU24 0NF, UK. cmfdadoel@gmail.com.|DCD Consulting Ltd, Alton, Hants, GU34 5BG, UK. cmfdadoel@gmail.com.
authors.forename: Claudia
authors.initials: C
authors.lastname: Doel
authors.affiliation: The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, GU24 0NF, UK. john.bashiruddin@btinternet.com.|JBBiologik, Farnham, Surrey, GU10 1DH, UK. john.bashiruddin@btinternet.com.
authors.forename: John B
authors.initials: JB
authors.lastname: Bashiruddin
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000821:virology; D005536:Foot-and-Mouth Disease / Q000276:immunology* / Q000821:virology; D029544:Foot-and-Mouth Disease Virus / Q000235:genetics / Q000502:physiology*; D007372:Interferons / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*
chemical_list: D016753:Interleukin-10; D007372:Interferons