title: To intervene or not? A man with multidrug-resistant hypertension, endovascular abdominal aneurysm repair, bilateral renal artery stenosis and end-stage renal disease salvaged with renal artery stenting.
abstract: We report the case of a 69-year-old man with uncontrolled multidrug-resistant secondary hypertension following a 10 year history of endovascular abdominal aortic aneurysm repair, with suprarenal fixation and concurrent angioplasty with stenting of the left renal artery for atherosclerotic renal disease, and progressive chronic kidney disease. Renal scintigraphy revealed complete loss of the right kidney's and severe reduction of the left kidney's perfusion and function. Following recent evidence and consultation with vascular surgeons regarding the technical difficulties of any procedure, escalation of antihypertensive treatment was initially chosen. Careful drug adjustments significantly improved but did not fully control blood pressure (BP); further, the patient experienced an acute ischaemic stroke and renal function deterioration towards end-stage renal disease within a few months. At this point, revascularization of the left renal artery coupled with three haemodialysis sessions to remove contrast media was justified as rescue therapy against permanent renal replacement therapy. Successful intervention achieved an immediate BP reduction, with BP fully controlled, despite a  > 70% decrease in antihypertensive treatment, while renal function improved at 6 months from 11.5 to 22 ml/min/1.73 m(2). Renal angioplasty confers undisputed benefits in BP control and nephroprotection, and should be offered without delay to patients with renovascular hypertension and/or ischaemic nephropathy.
authors.affiliation: a Department of Nephrology , Hippokration Hospital, Aristotle University of Thessaloniki , Thessaloniki , Greece ;
authors.forename: Pantelis A
authors.initials: PA
authors.lastname: Sarafidis
authors.affiliation: b Department of General and Vascular Surgery , Papageorgiou General Hospital, Aristotle University of Thessaloniki , Thessaloniki , Greece ;
authors.forename: Kyriakos C
authors.initials: KC
authors.lastname: Stavridis
authors.affiliation: a Department of Nephrology , Hippokration Hospital, Aristotle University of Thessaloniki , Thessaloniki , Greece ;
authors.forename: Charalampos N
authors.initials: CN
authors.lastname: Loutradis
authors.affiliation: c Department of Surgery , University Hospitals Coventry and Warwickshire , Coventry , UK ;
authors.forename: Athanasios N
authors.initials: AN
authors.lastname: Saratzis
authors.affiliation: d Department of Nephrology , Papageorgiou General Hospital , Thessaloniki , Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Pateinakis
authors.affiliation: a Department of Nephrology , Hippokration Hospital, Aristotle University of Thessaloniki , Thessaloniki , Greece ;
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Papagianni
authors.affiliation: a Department of Nephrology , Hippokration Hospital, Aristotle University of Thessaloniki , Thessaloniki , Greece ;
authors.forename: Georgios
authors.initials: G
authors.lastname: Efstratiadis
authors.affiliation: b Department of General and Vascular Surgery , Papageorgiou General Hospital, Aristotle University of Thessaloniki , Thessaloniki , Greece ;
authors.forename: Nicolaos
authors.initials: N
authors.lastname: Saratzis
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon; D000959:Antihypertensive Agents / Q000627:therapeutic use; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D001794:Blood Pressure / Q000187:drug effects; D018432:Drug Resistance, Multiple; D006801:Humans; D006978:Hypertension, Renovascular / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D008297:Male; D012077:Renal Artery / Q000473:pathology / Q000601:surgery*; D012078:Renal Artery Obstruction / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D015607:Stents; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents
keywords: Atherosclerotic renal disease; chronic kidney disease; ischaemic nephropathy; renal artery stenosis; secondary hypertension