title: Correlation between polymorphisms of hypoxia-inducible factor-1α Pro582Ser and type 2 diabetic nephropathy.
abstract: We examined the correlation between gene polymorphisms in hypoxia-inducible factor-1α (HIF-1α) Pro582Ser and type 2 diabetic nephropathy (DN). A total of 244 subjects with type 2 diabetes were recruited. The 1285-bp locus polymorphism of HIF-1α exon was detected using polymerase chain reaction-restriction fragment length polymorphism. C/T single nucleotide polymorphisms were detected at the site of 1285 bp of the HIF-1α exon, from a proline to a serine (Pro582Ser). The frequency of CT heterozygotes was significantly higher in DN patients than in diabetes patients (P < 0.05). Logistic regression analysis showed that high hemoglobin A1c and low high-density lipoprotein-cholesterol were risk factors for DN, and Pro582Ser was excluded in the equation. HIF-1α Pro582Ser single nucleotide polymorphisms may be correlated with type 2 DN, which needs further exploration.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Bi
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province, China.
authors.forename: G X
authors.initials: GX
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D008078:Cholesterol, LDL / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology; D003928:Diabetic Nephropathies / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006442:Glycated Hemoglobin / Q000235:genetics; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C497442:HIF1A protein, human; C517652:hemoglobin A1c protein, human