title: An unusual tumour of the lung.
abstract: We report a case of a 51-year-old woman with a solitary mast cell tumour of the lung, a rare neoplasm with only three previously-reported cases reported in the literature. Unlike previous cases, the tumour in the present case was bulky, measuring 14 cm in diameter and budding into the segmental bronchus. Histologically, it showed proliferation of typical metachromatic mast cells intermingled with undifferentiated cells with a ratio of 3:1. The neoplastic mast cells stained strongly with tryptase, CD117, CD68 and CD45, CD14 and CD33; whereas the undifferentiated cells lacked all these markers and expressed EMA and cytokeratin. Histological examination of bone marrow and laboratory data were unremarkable. To our knowledge, this is the fourth case of solitary extracutaneous mastocytoma of the lung. The differentiating features of this neoplasm and a review of literature are presented.
authors.forename: L
authors.initials: L
authors.lastname: Ayadi
authors.forename: N
authors.initials: N
authors.lastname: Abid
authors.forename: S
authors.initials: S
authors.lastname: Makni
authors.forename: I
authors.initials: I
authors.lastname: Bahri
authors.forename: I
authors.initials: I
authors.lastname: Frikha
authors.forename: T
authors.initials: T
authors.lastname: Sellami-Boudawara
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008407:Mast Cells / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D011013:Pneumonectomy; D011237:Predictive Value of Tests; D003074:Solitary Pulmonary Nodule / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor