title: Role of necroptosis in the pathogenesis of solid organ injury.
abstract: Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase independent. Increasing evidence has implicated necroptosis in the pathogenesis of disease, including ischemic injury, neurodegeneration, viral infection and many others. Key players of the necroptosis signalling pathway are now widely recognized as therapeutic targets. Necrostatins may be developed as potent inhibitors of necroptosis, targeting the activity of RIPK1. Necrostatin-1, the first generation of necrostatins, has been shown to confer potent protective effects in different animal models. This review will summarize novel insights into the involvement of necroptosis in specific injury of different organs, and the therapeutic platform that it provides for treatment.
authors.affiliation: Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: T
authors.initials: T
authors.lastname: Jaffer
authors.affiliation: Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Eguchi
authors.affiliation: Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Division of Nephrology and Hypertension, Christian-Albrechts-University, Kiel, Germany.
authors.forename: A
authors.identifier: http://orcid.org/0000-0001-6287-9725
authors.initials: A
authors.lastname: Linkermann
authors.affiliation: Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Ma
mesh_terms: D000007:Abdominal Injuries / Q000473:pathology; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D015601:Injury Severity Score; D009336:Necrosis / Q000473:pathology; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000473:pathology*