title: Effects of Different Therapeutic Ultrasound Waveforms on Endothelial Function in Healthy Volunteers: A Randomized Clinical Trial.
abstract: The purpose of this study was to determine the effects of different therapeutic 1-MHz ultrasound waveforms on endothelial function before and after cyclooxygenase (COX) inhibition. Forty-two healthy volunteers aged 27.2 ± 3.8 y underwent interventions and an evaluation for endothelial function (n = 15; with COX inhibition, n = 15; duration of the vasodilator effect, n = 12) by technique flow-mediated dilation. Continuous ultrasound therapy (0.4 W/cm(2 SATA)), pulsed ultrasound therapy (20% duty cycle, 0.08 W/cm(2 SATA)) or placebo (equipment power off) was randomly applied over the brachial artery for 5 min. COX inhibition (aspirin) was carried out 30 min before treatments. In relation to the placebo, flow-mediated dilation increased by 4.8% using continuous ultrasound and by 3.4% using pulsed ultrasound. After COX, flow-mediated dilation was enhanced by 2.1% by continuous ultrasound and 2.6% by pulsed ultrasound. This vasodilation persisted for 20 min. Continuous and pulsed therapeutic 1-MHz ultrasound waveforms improved endothelial function in humans, which provided them with anti-inflammatory vascular effects.
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande, Rio Grande do Sul, Brazil.
authors.forename: Jeferson Mendes
authors.initials: JM
authors.lastname: Cruz
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande, Rio Grande do Sul, Brazil.
authors.forename: Melina
authors.initials: M
authors.lastname: Hauck
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande, Rio Grande do Sul, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Cardoso Pereira
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande, Rio Grande do Sul, Brazil.
authors.forename: Maicon Borges
authors.initials: MB
authors.lastname: Moraes
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande, Rio Grande do Sul, Brazil.
authors.forename: Cassio Noronha
authors.initials: CN
authors.lastname: Martins
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande, Rio Grande do Sul, Brazil.
authors.forename: Felipe
authors.initials: F
authors.lastname: da Silva Paulitsch
authors.affiliation: Departamento de Fisioterapia, Universidade Federal de Ciências da Saúde de Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Rodrigo Della Méa
authors.initials: RD
authors.lastname: Plentz
authors.affiliation: Universidade Federal de Pelotas, Rio Grande do Sul, Brazil.
authors.forename: William
authors.initials: W
authors.lastname: Peres
authors.affiliation: Departamento de Fisioterapia e Reabilitação, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Antônio Marcos
authors.initials: AM
authors.lastname: Vargas da Silva
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande, Rio Grande do Sul, Brazil; Departamento de Fisioterapia e Reabilitação, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil. Electronic address: l.signori@hotmail.com.
authors.forename: Luis Ulisses
authors.initials: LU
authors.lastname: Signori
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D001916:Brachial Artery / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects*; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*; D000069453:Ultrasonic Waves; D014664:Vasodilation / Q000502:physiology / Q000528:radiation effects; D014665:Vasodilator Agents / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D014665:Vasodilator Agents; D001241:Aspirin
keywords: Cyclooxygenase inhibitors; Endothelial function; Nitric oxide; Ultrasonic therapy; Ultrasound; Vascular endothelium