title: Fat Quality Influences the Obesogenic Effect of High Fat Diets.
abstract: High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.
authors.affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. rcrescen@unina.it.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Crescenzo
authors.affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. francibianco@yahoo.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Bianco
authors.affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. arimazzoli@hotmail.it.
authors.forename: Arianna
authors.initials: A
authors.lastname: Mazzoli
authors.affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. antonia.giacco@hotmail.it.
authors.forename: Antonia
authors.initials: A
authors.lastname: Giacco
authors.affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. cancelliererosa@gmail.com.
authors.forename: Rosa
authors.initials: R
authors.lastname: Cancelliere
authors.affiliation: Department of Chemical Sciences, Federico II University, Via Cinthia, 80138 Naples, Italy. difabio@unina.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: di Fabio
authors.affiliation: Department of Chemical Sciences, Federico II University, Via Cinthia, 80138 Naples, Italy. zarrelli@unina.it.|Inter-University Consortium SannioTech, Piazza San G. Moscati, 82030 Apollosa (BN), Italy. zarrelli@unina.it.
authors.forename: Armando
authors.initials: A
authors.lastname: Zarrelli
authors.affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. liverini@unina.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Liverini
authors.affiliation: Department of Biology, Federico II University, Via Cinthia, 80138 Naples, Italy. susiossa@unina.it.
authors.forename: Susanna
authors.initials: S
authors.lastname: Iossa
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000008:administration & dosage* / Q000032:analysis; D004734:Energy Metabolism; D005223:Fats / Q000737:chemistry*; D005227:Fatty Acids / Q000008:administration & dosage / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000097:blood; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism; D008043:Linseed Oil / Q000008:administration & dosage / Q000032:analysis; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000503:physiopathology*; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D012450:Safflower Oil / Q000008:administration & dosage / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D000071256:Uncoupling Protein 1
chemical_list: D015415:Biomarkers; D004041:Dietary Fats; D005223:Fats; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D007473:Ion Channels; D024101:Mitochondrial Proteins; D014280:Triglycerides; D000071256:Uncoupling Protein 1; D012450:Safflower Oil; D008043:Linseed Oil; D002784:Cholesterol; D000410:Alanine Transaminase; C029310:lard
keywords: hepatic steatosis; high fat diet; lipid peroxidation; unsaturated fatty acids