title: Correlation between ABO Blood Group, and Conventional Hematological and Metabolic Parameters in Blood Donors.
abstract: BACKGROUND
  Although several studies have investigated and confirmed the existence of an association between ABO blood type and several human disorders, especially with cardiovascular disease, little is known on the physiological influence or association of ABO blood groups on basal levels of some conventional hematological and metabolic parameters.
  
  
  METHODS
  A total number of 7,723 consecutive healthy blood donors underwent laboratory testing at the time of their first blood donation, which apart from ABO typing included assessment of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, total bilirubin, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides, creatinine, iron, ferritin, uric acid, glucose, hemoglobin, and platelet count.
  
  
  RESULTS
  The most relevant finding was the identification of significantly higher values of total cholesterol and HDL-c in subjects with blood group A compared with those with O blood type, with the highest levels being observed in A1 subtype.
  
  
  CONCLUSIONS
  The positive association between A blood type and plasma lipid levels supports its potential role in the pathogenesis of atherosclerosis and the clinical observations of increased vulnerability to cardiovascular disease of individuals with non-O blood groups.
authors.affiliation: Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.affiliation: University of Padova, Padova, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Mengoli
authors.affiliation: Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Capuzzo
authors.affiliation: Laboratory, Carlo Poma Hospital, Mantova, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Terenziani
authors.affiliation: Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Bonfanti
authors.affiliation: Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000097:blood; D001782:Blood Donors; D001786:Blood Glucose / Q000378:metabolism*; D001798:Blood Proteins / Q000032:analysis / Q000378:metabolism*; D003404:Creatinine / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies
chemical_list: D000017:ABO Blood-Group System; D001786:Blood Glucose; D001798:Blood Proteins; D008055:Lipids; D005293:Ferritins; D003404:Creatinine; D007501:Iron