title: Controlled Antibiotics Release System through Simple Blended Electrospun Fibers for Sustained Antibacterial Effects.
abstract: Implantation of sustained antibacterial system after abdominal surgery could effectively prevent complicated intra-abdominal infection. In this study, a simple blended electrospun membrane made of poly(D,L-lactic-co-glycolide) (PLGA)/poly(dioxanone) (PDO)/Ciprofloxacin hydrochloride (CiH) could easily result in approximately linear drug release profile and sustained antibacterial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The addition of PDO changed the stack structure of PLGA, which in turn influenced the fiber swelling and created drug diffusion channels. It could be a good candidate for reducing postoperative infection or be associated with other implant to resist biofilm formation.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.|University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors.forename: Zixin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Huadong Hospital affiliated to Fudan University , Shanghai 200040, P. R. China.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Tang
authors.affiliation: Torch High Technology Industry Development Center, Ministry of Science and Technology , Beijing 100045, P. R. China.
authors.forename: Heran
authors.initials: H
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.|University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Xia
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Charles C
authors.initials: CC
authors.lastname: Han
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000737:chemistry / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D019344:Lactic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D016687:Polydioxanone / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D016687:Polydioxanone; D019344:Lactic Acid; D002939:Ciprofloxacin
keywords: antibacterial activity; bicomponent; control release; electrospinning; intra-abdominal infections