title: Therapeutic effects of Zataria Multiflora essential oil on recurrent oral aphthous lesion.
abstract: BACKGROUND
  Aphthous lesions are one of the most common diseases of the oral cavity. They can cause severe pain, and there is no definite treatment. The purpose of this study was to determine the efficacy of Zataria multiflora (ZM, a thyme-like plant) essential oil for the control and treatment of aphthous lesions.
  
  
  METHODS
  This Triple blind clinical trial study was performed on 28 patients who were divided into two groups (eight men and six women in each group) and given ZM or placebo (control). The healing time, pain intensity, and aphthous zone diameter were recorded for each patient and followed for 6-month. Data were analyzed using Mann-Whitney and Friedman tests (P < 0.05).
  
  
  RESULTS
  After 6-month of follow-up, 4 patients in the placebo group and 6 patients in the ZM group suffered from recurrent aphthous lesions. The average complete healing time and duration of burning sensation were significantly lower in the ZM group (P < 0.05). Significant difference was observed between the two groups with regard to the diameter of lesions and halo of the lesions (P < 0.05).
  
  
  CONCLUSIONS
  Within the limitations of this study, ZM shortened the healing period compared to placebo.
authors.affiliation: Department of Oral Medicine, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Babaee
authors.affiliation: Department of Pharmacology, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Baradaran
authors.affiliation: Department of General dentist, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Mohamadi
authors.affiliation: Department of Peridontics/Member of Research Committee, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Nooribayat
keywords: Aphthous stomatitis; multiflorol; therapeutics