title: PCOSKB: A KnowledgeBase on genes, diseases, ontology terms and biochemical pathways associated with PolyCystic Ovary Syndrome.
abstract: Polycystic ovary syndrome (PCOS) is one of the major causes of female subfertility worldwide and ≈ 7-10% of women in reproductive age are affected by it. The affected individuals exhibit varying types and levels of comorbid conditions, along with the classical PCOS symptoms. Extensive studies on PCOS across diverse ethnic populations have resulted in a plethora of information on dysregulated genes, gene polymorphisms and diseases linked to PCOS. However, efforts have not been taken to collate and link these data. Our group, for the first time, has compiled PCOS-related information available through scientific literature; cross-linked it with molecular, biochemical and clinical databases and presented it as a user-friendly, web-based online knowledgebase for the benefit of the scientific and clinical community. Manually curated information on associated genes, single nucleotide polymorphisms, diseases, gene ontology terms and pathways along with supporting reference literature has been collated and included in PCOSKB (http://pcoskb.bicnirrh.res.in).
authors.affiliation: Biomedical Informatics Center of Indian Council of Medical Research, National Institute for Research in Reproductive Health, Mumbai-400012, India.
authors.forename: Shaini
authors.initials: S
authors.lastname: Joseph
authors.affiliation: Biomedical Informatics Center of Indian Council of Medical Research, National Institute for Research in Reproductive Health, Mumbai-400012, India.
authors.forename: Ram Shankar
authors.initials: RS
authors.lastname: Barai
authors.affiliation: G.N. Khalsa College, University of Mumbai, India.
authors.forename: Rasika
authors.initials: R
authors.lastname: Bhujbalrao
authors.affiliation: Biomedical Informatics Center of Indian Council of Medical Research, National Institute for Research in Reproductive Health, Mumbai-400012, India thomass@nirrh.res.in.
authors.forename: Susan
authors.initials: S
authors.lastname: Idicula-Thomas
mesh_terms: D001669:Biochemical Phenomena; D015897:Comorbidity; D062126:Databases, Chemical; D016208:Databases, Factual; D005260:Female; D063990:Gene Ontology; D053263:Gene Regulatory Networks; D006801:Humans; D051188:Knowledge Bases; D009154:Mutation; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011487:Protein Conformation