title: Transsynaptic Coordination of the Formation of Morphofunctional Contacts between the Brain and the Neurotransplant: an Ulrastructural Study.
abstract: We studied the role of neurotransmitter signaling mediated by synaptic vesicles in the formation of aberrant functional connections between fascia dentata grafts and the somatosensory neocortex in adult rats. Quantitative analysis of the different populations of synaptic vesicles in the ectopic giant axonal endings of granular neurons was performed and the results were compared with the normal. Two pools of small clear vesicles (rapidly releasable pool and pool of reserve vesicles circulating in the active zone) and one pool of large dense-core vesicles were analyzed. Significant differences from the control suggest that synaptic integration of the transplants into the recipient brain is coordinated by transsynaptic signaling and mediated by different populations of synaptic vesicles.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. zhuravleva@iteb.ru.
authors.forename: Z N
authors.initials: ZN
authors.lastname: Zhuravleva
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Science, Pushchino, Moscow Region, Russia.
authors.forename: G I
authors.initials: GI
authors.lastname: Zhuravlev
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Mugantseva
mesh_terms: D000818:Animals; D016380:Brain Tissue Transplantation; D002450:Cell Communication; D018891:Dentate Gyrus / Q000637:transplantation* / Q000648:ultrastructure; D016332:Fetal Tissue Transplantation; D006085:Graft Survival; D008297:Male; D008855:Microscopy, Electron, Scanning; D019599:Mossy Fibers, Hippocampal / Q000378:metabolism / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure; D018377:Neurotransmitter Agents / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D022142:Secretory Vesicles / Q000378:metabolism / Q000648:ultrastructure; D013003:Somatosensory Cortex / Q000601:surgery / Q000648:ultrastructure*; D013572:Synaptic Vesicles / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D018377:Neurotransmitter Agents
keywords: fascia dentata; neocortex; neurotransplant; pool of the synaptic vesicles; ultrastructure