title: Biocompatibility and Structural Features of Biodegradable Polymer Scaffolds.
abstract: We performed a comparative analysis of physicochemical properties and biocompatibility of scaffolds of different composition on the basis of biodegradable polymers fabricated by casting and electrospinning methods. For production of polyhydroxyalkanoate-based scaffolds by electrospinning method, the optimal concentration of the polymer was 8-10%. Fiber diameter and properties of the scaffold produced by electrospinning method depended on polymer composition. Addition of polycaprolactone increased elasticity of the scaffolds. Bio- and hemocompatibility of the scaffolds largely depended on the composition formulation and method of scaffold fabrication. Polylactide introduced into the composition of polyhydroxybutyrate-oxyvalerate scaffolds accelerated degradation and increased adhesive properties of the scaffolds.
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Division of the Russian Academy of Medical Sciences, Kemerovo, Russia. mv-nas@mail.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Nasonova
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Division of the Russian Academy of Medical Sciences, Kemerovo, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Glushkova
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Division of the Russian Academy of Medical Sciences, Kemerovo, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Borisov
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Division of the Russian Academy of Medical Sciences, Kemerovo, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Velikanova
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Division of the Russian Academy of Medical Sciences, Kemerovo, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Burago
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Division of the Russian Academy of Medical Sciences, Kemerovo, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Kudryavtseva
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001792:Blood Platelets; D002448:Cell Adhesion; D004548:Elasticity; D004912:Erythrocytes; D005347:Fibroblasts; D006801:Humans; D051379:Mice; D011091:Polyesters; D054813:Polyhydroxyalkanoates; D017208:Rats, Wistar; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry; D000094122:Polyhydroxybutyrates
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D054813:Polyhydroxyalkanoates; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates; C016240:polycaprolactone; C033616:poly(lactide)
keywords: biocompatibility; biodegradable polymers; electrospinning; scaffolds; tissue engineering