title: [APPLICATION OF DEXMEDETOMIDIN FOR SEDATION OF PATIENTS IN ALCOHOL WITHDRAWAL STATE IN THE ICU].
abstract: The efficacy and safety of sedation on 44 patients in alcohol withdrawal state (AWS) for use of intravenous dexmedetomidine infusion. Dexmedetomidine increased the duration of target sedation level to 20%, decreased the duration of excessive/insufficient sedation to 10%, it was associated with AWS symptoms regression, better communication with the patient, reduced consumption of benzodiazepines (BZD) from 40 to 30 mg per day and antypsihotics for control AWS symptoms. The common complications of dexmedetomidine infusion were bradycardia and hypotension. Dexmedetomidine could be an alternative drug for sedation patients with mild or moderate AWS and applied in addition to BZD and antipsyhotics in patients with severe AWS.
authors.forename: K Yu
authors.initials: KY
authors.lastname: Belka
mesh_terms: D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology / Q000601:surgery; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000009:adverse effects; D000768:Anesthesia, General / Q000379:methods*; D018686:Anesthetics, Intravenous; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001919:Bradycardia / Q000139:chemically induced / Q000503:physiopathology; D020927:Dexmedetomidine / Q000008:administration & dosage* / Q000009:adverse effects; D003975:Diazepam; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D059408:Pain Management / Q000379:methods*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D018686:Anesthetics, Intravenous; D014150:Antipsychotic Agents; D020927:Dexmedetomidine; D006220:Haloperidol; D003975:Diazepam