title: [First trimester uric acid and adverse pregnancy outcomes in patients with chronic glomerulonephritis during pregnancy].
abstract: BACKGROUND
  The association between hyperuricemia and adverse perinatal outcome has been studied on numerous occasions, particularly in relation to hypertension and preeclampsia.
  
  
  OBJECTIVE
  The objective of this study is to analyze the predictive value of serum concentrations of uric acid during the first trimester of pregnancy for adverse perinatal outcome in women with glomerulopathies.
  
  
  METHODS
  Twenty-five women diagnosed with glomerulonephritis at the Instituto Nacional de Perinatología were included in this study. The determination of serum uric acid concentration was made between 7 and 12 weeks of gestation.
  
  
  RESULTS
  We finding that Uric acid level in the first trimester showed a significant correlation with blood pressure in the third trimester (Spearman rho coefficient: 0.45, p = 0.04,), with weeks of gestation at birth (Spearman rho coefficient: -0.42, p 0.05), and with weight at birth (Spearman rho coefficient: -0.61 p = 0.003).
  
  
  CONCLUSIONS
  The findings of our study suggest the clinical utility of determining and interpreting uric acid in the first trimester in patients with glomerulopathias and mild renal insufficiency (creatinine less than 1.4 mg/dL), and a threshold of 4.8 mg/dL to consider at which a patient can be considered at high risk of premature birth, low birth weight, and preeclampsia.
authors.forename: Karina Arlén
authors.initials: KA
authors.lastname: Sequeira-Alvarado
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Hernández-Pachecol
authors.forename: Salvador
authors.initials: S
authors.lastname: Espino y Sosa
mesh_terms: D000328:Adult; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D005921:Glomerulonephritis / Q000097:blood*; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid