title: Cutaneous T-cell lymphoma: 2016 update on diagnosis, risk-stratification, and management.
abstract: BACKGROUND
  Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).
  
  
  METHODS
  The diagnosis of MF or SS requires the integration of clinical and histopathologic data.
  
  
  METHODS
  TNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a "risk-adapted," multidisciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin-directed therapies is preferred, as both disease-specific and overall survival for these patients is favorable. In contrast, patients with advanced-stage disease with significant nodal, visceral, or blood involvement are generally approached with biologic-response modifiers or histone deacetylase inhibitors before escalating therapy to include systemic, single-agent chemotherapy. In highly-selected patients, allogeneic stem-cell transplantation may be considered, as this may be curative in some patients.
authors.affiliation: Division of Hematology/Oncology, University of Michigan Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Wilcox
mesh_terms: D056572:Histone Deacetylase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D009182:Mycosis Fungoides / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D009367:Neoplasm Staging; D018570:Risk Assessment; D012751:Sezary Syndrome / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D012878:Skin Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D033581:Stem Cell Transplantation; D016019:Survival Analysis
chemical_list: D056572:Histone Deacetylase Inhibitors