title: "Bringing Up Baby" to Tolerate Germs.
abstract: How immune tolerance is maintained in the skin remains unclear. In this issue of Immunity, Rosenblum and colleagues demonstrate that tolerance to commensal bacteria is established during the neonatal period via regulatory T cells. Defining the crucial window during which commensal-specific tolerance is achieved has strategic implications for the induction of tolerance in allergic diseases.
authors.affiliation: Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: keisuke.nagao@nih.gov.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nagao
authors.affiliation: Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address: jsegre@nhgri.nih.gov.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Segre
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D012867:Skin / Q000276:immunology* / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000276:immunology*; D013212:Staphylococcus epidermidis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*