title: Diagnostic and Therapeutic Applications of Quantum Dots in Nanomedicine.
abstract: The interest in Quantum Dots as a class of nanomaterials has grown considerably since their discovery by Ekimov and Efros in the early 1980s. Although this early work focussed primarily on CdSe-based nanocrystals, the field has now expanded to include various classes of nanoparticles with different types of core, shell or passivation chemistry. Such differences can have a profound effect on the optical properties and potential biocompatibility of the resulting constructs. Although QDs have predominantly been used for imaging and sensing applications, more examples of their use as therapeutics are beginning to emerge. In this chapter we discuss the progress made over the past decade in developing QDs for imaging and therapeutic applications.
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK.
authors.forename: Sukanta
authors.initials: S
authors.lastname: Kamila
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK.
authors.forename: Conor
authors.initials: C
authors.lastname: McEwan
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK.
authors.forename: David
authors.initials: D
authors.lastname: Costley
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK.
authors.forename: Jordan
authors.initials: J
authors.lastname: Atchison
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK.
authors.forename: Yinjie
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK.
authors.forename: Graham R C
authors.initials: GR
authors.lastname: Hamilton
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK.
authors.forename: Colin
authors.initials: C
authors.lastname: Fowley
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK. j.callan@ulster.ac.uk.
authors.forename: John F
authors.initials: JF
authors.lastname: Callan
mesh_terms: D006801:Humans; D050997:Nanomedicine; D010778:Photochemotherapy; D045663:Quantum Dots; D021701:Sentinel Lymph Node Biopsy
keywords: Cancer; Fluorescence; Microbiology; Photodynamic therapy; Quantum dots; ROS