title: Melanoma targeting with the loco-regional chemotherapeutic, Melphalan: From cell death to immunotherapeutic efficacy.
abstract: All immunoregulatory chemotherapeutics are chiefly applied in a systemic setting for anticancer therapy. However, immune responses following loco-regional application of chemotherapy may differ from those after systemic application. We recently found that Melphalan, a prototypical loco-regionally applied chemotherapeutic agent, exhibits the ability to increase the immunogenicity of dying melanoma cells.
authors.affiliation: Cell Death Research and Therapy Laboratory, Department of Cellular and Molecular Medicine; Faculty of Medicine ; KU Leuven , Leuven, Belgium.
authors.forename: Aleksandra Maria
authors.initials: AM
authors.lastname: Dudek-Perić
authors.affiliation: Department of Immunology; Center of Biostructure Research; Medical University of Warsaw ; Warsaw, Poland ; Institute of Physical Chemistry; Polish Academy of Sciences ; Warsaw, Poland.
authors.forename: Jakub
authors.initials: J
authors.lastname: Gołąb
authors.affiliation: Cell Death Research and Therapy Laboratory, Department of Cellular and Molecular Medicine; Faculty of Medicine ; KU Leuven , Leuven, Belgium.
authors.forename: Abhishek D
authors.initials: AD
authors.lastname: Garg
authors.affiliation: Cell Death Research and Therapy Laboratory, Department of Cellular and Molecular Medicine; Faculty of Medicine ; KU Leuven , Leuven, Belgium.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Agostinis
keywords: chemotherapy; danger signals; immunogenicity; immunotherapy; melanoma