title: Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower Type 2 Diabetes Risk.
abstract: Combining metformin with exercise has been proposed to improve glucose homeostasis. However, we primarily discuss evidence suggesting that metformin and other pharmacological agents/dietary supplements (e.g., statins, resveratol, or antioxidants) may in fact oppose exercise-induced benefits on insulin sensitivity and cardiometabolic health. We explore the novel hypothesis that attenuation of oxidative stress from exercise by these exogenous compounds blunts metabolic adaptation.
authors.affiliation: 1Department of Kinesiology and 2Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA; and 3Department of Health and Exercise Science, Colorado State University, Fort Collins, CO.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Malin
authors.forename: Barry
authors.initials: B
authors.lastname: Braun
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000628:therapy*; D003925:Diabetic Angiopathies / Q000517:prevention & control; D005081:Exercise Therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007333:Insulin Resistance; D008687:Metformin / Q000627:therapeutic use*; D018384:Oxidative Stress; D010809:Physical Fitness; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008687:Metformin