title: Association Between IL-17A +197 G/A Polymorphism and Cancer Risk: A Meta-analysis.
abstract: OBJECTIVE
  The association between interleukin-17 (IL-17) gene polymorphism and cancer is controversial. Thus, we performed a meta-analysis to evaluate the correlation between this gene variant and cancer risk.
  
  
  METHODS
  We retrieved the available data from EMBASE and PUBMED through June, 2015, and evaluated the effect of the rs2273913 polymorphism in different ethnicities and cancer types. A meta-analysis was performed after data sorting.
  
  
  RESULTS
  Significant associations were confirmed among Asians by the allelic model (T allele vs. G allele, 95% confidence interval [95% CI] 1.304-2.120), homozygote comparison (AA vs. GG, 95% CI 1.073-1.615), and the recessive model (AA vs. AG/GG, 95% CI 1.128-1.778). We also demonstrated that rs2273913 confers a high risk of nongastrointestinal cancer based on the allelic model (T allele vs. G allele, 95% CI 2.288-3.442), homozygote comparison (AA vs. GG, 95% CI 1.312-1.925), and recessive model (AA vs. AG/GG, 95% CI 1.259-1.689).
  
  
  CONCLUSIONS
  Our present study indicates that the IL-17A +197 G/A/T polymorphism (rs2275913) is associated with the risk of cancer in Asian populations and nongastrointestinal cancers. Hence, rs2275913 might be useful as a diagnostic biomarker of cancer in these populations.
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital, Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University , Nanjing, China .
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital, Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University , Nanjing, China .
authors.forename: Jian
authors.initials: J
authors.lastname: Gu
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital, Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University , Nanjing, China .
authors.forename: Hao
authors.initials: H
authors.lastname: Lu
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital, Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University , Nanjing, China .
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital, Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University , Nanjing, China .
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital, Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University , Nanjing, China .
authors.forename: Xuehao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital, Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University , Nanjing, China .
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital, Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University , Nanjing, China .
authors.forename: Chuanyong
authors.initials: C
authors.lastname: Zhang
mesh_terms: D044466:Asian People; D014408:Biomarkers, Tumor / Q000235:genetics*; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D014408:Biomarkers, Tumor; C508717:IL17A protein, human; D020381:Interleukin-17; D009363:Neoplasm Proteins