title: Cornoid Lamella-Like Structures in HIV-Associated Epidermodysplasia Verruciformis: A Unique Histopathologic Finding.
abstract: Epidermodysplasia verruciformis (EV) is an uncommon inherited skin condition with increased vulnerability to widespread infection by certain human papillomavirus types, resulting in extensive verruca plana-like papules coalescing to large confluent plaques. Since the AIDS epidemic starting in the 1980s, an acquired type of EV has been described in patients infected with human immunodeficiency virus. The histopathologic features of EV consist of papillated epidermal hyperplasia with hypergranulosis and a distinct bluish-gray color in the large human papillomavirus-infected keratinocytes in the stratum granulosum. The authors present a case of HIV-associated EV with a unique histopathologic finding of multiple cornoid lamella-like structures. To the authors' knowledge, this finding has not been previously described in the literature.
authors.affiliation: *Department of Dermatology, University of Missouri, Columbia, MO; †Department of Dermatology, Laboratory for Molecular Studies in Mucocutaneous Diseases, University of Texas Health Science Center at Houston, Houston, TX; and Departments of ‡Dermatology, and §Pathology, University of California, San Francisco, San Francisco, CA.
authors.forename: Courtney
authors.initials: C
authors.lastname: Champagne
authors.forename: Lindsey
authors.initials: L
authors.lastname: Moore
authors.forename: Ross
authors.initials: R
authors.lastname: Reule
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Dyer
authors.forename: Peter
authors.initials: P
authors.lastname: Rady
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Tyring
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: North
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D004819:Epidermodysplasia Verruciformis / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host