title: Aging, cytomegalovirus (CMV) and influenza vaccine responses.
abstract: Influenza vaccination is less effective in elderly as compared to young individuals. Several studies have identified immune biomarkers able to predict a protective humoral immune response to the vaccine. In this review, we summarize current knowledge on the effects of aging on influenza vaccine responses and on biomarkers so far identified, and we discuss the relevance of latent cytomegalovirus (CMV) infection on these vaccine responses.
authors.affiliation: a Department of Microbiology and Immunology , University of Miami Miller School of Medicine , Miami , FL , USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Frasca
authors.affiliation: a Department of Microbiology and Immunology , University of Miami Miller School of Medicine , Miami , FL , USA.
authors.forename: Bonnie B
authors.initials: BB
authors.lastname: Blomberg
mesh_terms: D000375:Aging; D000914:Antibodies, Viral / Q000097:blood; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines
keywords: Aging; B cells; CMV; influenza vaccine