title: Histopathological gallbladder morphometric measurements in geriatric patients with symptomatic chronic cholecystitis.
abstract: BACKGROUND
  Cholecystectomy for symptomatic cholecystitis is one of the common surgical procedures in the geriatric patients. Increased gallbladder wall thickness is expected due to acute cholecystitis and in some other clinical conditions. Routine histopathological evaluation of cholecystectomy materials are required to confirm the diagnosis and document other pathologies. The aim of this study was to evaluate age-related histopathological gallbladder morphometric measurements.
  
  
  METHODS
  A retrospective chart review of 371 cholecystectomy materials was performed. Two groups were designed according to age (<65 and ≥65 years old, respectively). Age and gender analyses for histopathological gallbladder length, diameter and wall thickness were performed. In addition, pathologically confirmed acute inflammation rates were evaluated in this case-control study.
  
  
  RESULTS
  Gallbladder morphometric measurements and pathologically confirmed acute inflammation rates were similar in males and females. Histopathological gallbladder diameter was higher with acute inflammatory changes, but no differences were observed in gallbladder length and wall thickness. Gallbladder wall thickness and pathologically confirmed acute inflammation rates were not comparable between the control and geriatric patients (2.8 ± 1.3 vs 2.6 ± 1.2 mm, and 30/281 (10.7 %) vs 10/74 (13.5 %), respectively, p > 0.05). However, higher gallbladder length and diameter were observed in geriatric group.
  
  
  CONCLUSIONS
  Age is an independent factor on histopathological gallbladder length and diameter, but not for gallbladder wall thickness. In addition, pathologically confirmed acute inflammation rate is not higher in geriatric patients. Clinical significance of these findings merits further investigation.
authors.affiliation: Department of General Surgery, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Yaylak
authors.affiliation: Department of Pathology, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Deger
authors.affiliation: Department of General Surgery, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey. zulfubayhan@gmail.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Bayhan
authors.affiliation: Department of Pathology, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Kocak
authors.affiliation: Department of General Surgery, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Zeren
authors.affiliation: Department of Biochemistry, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey.
authors.forename: F E
authors.initials: FE
authors.lastname: Kocak
authors.affiliation: Department of General Surgery, Evliya Celebi Education and Training Hospital, 43020, Kutahya, Turkey.
authors.forename: M F
authors.initials: MF
authors.lastname: Ekici
authors.affiliation: Department of General Surgery, Dumlupinar University Faculty of Medicine, 43020, Kutahya, Turkey.
authors.forename: M C
authors.initials: MC
authors.lastname: Algın
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002764:Cholecystitis / Q000473:pathology*; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D005704:Gallbladder / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
keywords: Acute inflammation; Age; Cholecystectomy; Chronic cholecystitis; Gallbladder; Geriatric patient; Geriatrics