title: Effects of Sevoflurane and Propofol on Organ Blood Flow in Left Ventricular Assist Devices in Pigs.
abstract: The aim of this study was to assess the effect of sevoflurane and propofol on organ blood flow in a porcine model with a left ventricular assist device (LVAD). Ten healthy minipigs were divided into 2 groups (5 per group) according to the anesthetic received (sevoflurane or propofol). A Biomedicus centrifugal pump was implanted. Organ blood flow (measured using colored microspheres), markers of tissue injury, and hemodynamic parameters were assessed at baseline (pump off) and after 30 minutes of partial support. Blood flow was significantly higher in the brain (both frontal lobes), heart (both ventricles), and liver after 30 minutes in the sevoflurane group, although no significant differences were recorded for the lung, kidney, or ileum. Serum levels of alanine aminotransferase and total bilirubin were significantly higher after 30 minutes in the propofol group, although no significant differences were detected between the groups for other parameters of liver function, kidney function, or lactic acid levels. The hemodynamic parameters were similar in both groups. We demonstrated that, compared with propofol, sevoflurane increases blood flow in the brain, liver, and heart after implantation of an LVAD under conditions of partial support.
authors.affiliation: Department of Anesthesiology and Intensive Care, Gregorio Marañón University General Hospital, 28007 Madrid, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Morillas-Sendín
authors.affiliation: Department of Experimental Medicine and Surgery, Gregorio Marañón University General Hospital, 28007 Madrid, Spain Department of Experimental Medicine and Surgery, Gregorio Marañón University General Hospital, 28007 Madrid, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Delgado-Baeza
authors.affiliation: Department of Experimental Medicine and Surgery, Gregorio Marañón University General Hospital, 28007 Madrid, Spain Department of Experimental Medicine and Surgery, Gregorio Marañón University General Hospital, 28007 Madrid, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Delgado-Martos
authors.affiliation: Department of Anesthesiology and Intensive Care, Gregorio Marañón University General Hospital, 28007 Madrid, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: Barranco
authors.affiliation: Department of Experimental Medicine and Surgery, Gregorio Marañón University General Hospital, 28007 Madrid, Spain Department of Experimental Medicine and Surgery, Gregorio Marañón University General Hospital, 28007 Madrid, Spain.
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: del Cañizo
authors.affiliation: Department of Cardiac Surgery, Gregorio Marañón University General Hospital, 28007 Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ruíz
authors.affiliation: Department of Anesthesiology and Intensive Care, Gregorio Marañón University General Hospital, 28007 Madrid, Spain ; Department of Pharmacology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Quintana-Villamandos
mesh_terms: D000818:Animals; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage*; D000077149:Sevoflurane; D013552:Swine; D013556:Swine, Miniature; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol