title: Reconstruction and analysis of a genome-scale metabolic model for Eriocheir sinensis eyestalks.
abstract: The eyestalk of Eriocheir sinensis has significant biological functions with many nerve peptide hormones expressed in the X-organ which exists in the eyestalk. A metabolic network model is an effective tool for the systematic study of E. sinensis eyestalks. In this work, we reconstructed a metabolic network model for E. sinensis eyestalks based on transcriptome sequencing. The model contains 1304 reactions, 1381 unigenes and 1243 metabolites distributing in 98 pathways. The reconstructed metabolic network model was used for the functional module and block metabolite analysis of eyestalks, which reveals that the function of the eyestalk network agrees with its function as the centre of the E. sinensis endocrine system. The difference expression analysis of reactions in the model indicates that the eyestalk mainly functions in the regulation of amino acids, carbohydrate and nucleotide metabolism.
authors.affiliation: College of Life Sciences, Henan Normal University, Xinxiang 453007, Henan, P. R. China. nqjnqj1964@163.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Qianji
authors.initials: Q
authors.lastname: Ning
authors.forename: Tong
authors.initials: T
authors.lastname: Hao
authors.forename: Ailing
authors.initials: A
authors.lastname: Yu
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Sun
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D003386:Brachyura / Q000235:genetics* / Q000378:metabolism*; D003198:Computer Simulation; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D055106:Genome-Wide Association Study / Q000379:methods; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D059467:Transcriptome
chemical_list: D000596:Amino Acids