title: The role of circulating miRNAs in multiple myeloma.
abstract: Multiple myeloma (MM) is a common malignant hematological disease. Dysregulation of microRNAs (miRNAs) in MM cells and bone marrow microenviroment has important impacts on the initiation and progression of MM and drug resistance in MM cells. Recently, it was reported that MM patient serum and plasma contained sufficiently stable miRNA signatures, and circulating miRNAs could be identified and measured accurately from body fluid. Compared to conventional diagnostic parameters, the circulating miRNA profile is appropriate for the diagnosis of MM and estimates patient progression and therapeutic outcome with higher specificity and sensitivity. In this review, we mainly focus on the potential of circulating miRNAs as diagnostic, prognostic, and predictive biomarkers for MM and summarize the general strategies and methodologies for identification and measurement of circulating miRNAs in various cancers. Furthermore, we discuss the correlation between circulating miRNAs and the cytogenetic abnormalities and biochemical parameters assessed in multiple myeloma.
authors.affiliation: Department of Hematology, The First Affiliated Hospital, University of South China, Hengyang, 421001, China.|State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, 410078, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, 410078, China.
authors.forename: XiaoJuan
authors.initials: X
authors.lastname: Xiao
authors.affiliation: State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, 410078, China. jingliucsu@hotmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D018450:Disease Progression; D020869:Gene Expression Profiling / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D009101:Multiple Myeloma / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: biomarker; diagnosis; miRNA; multiple myeloma