title: RAG Off-Target Activity Is in the Loop.
abstract: The 'off-target' activity of RAG recombinases contributes to mutations and cancer. Recent studies show that the influence of DNA regulatory elements is largely constrained by the formation of chromatin loops and interaction frequencies. Now, the Alt lab has identified major RAG off-target activity bearing similar limitations, with joining events restricted to convergent paired RSS elements in loop domains.
authors.affiliation: Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Lili
authors.initials: L
authors.lastname: Blumenberg
authors.affiliation: Department of Pathology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: jane.skok@med.nyu.edu.
authors.forename: Jane A
authors.initials: JA
authors.lastname: Skok
mesh_terms: D000818:Animals; D016678:Genome; D059014:High-Throughput Nucleotide Sequencing; D051379:Mice; D008954:Models, Biological; D021382:Protein Sorting Signals; D045522:Recombinases / Q000378:metabolism*; D060152:V(D)J Recombination / Q000235:genetics
chemical_list: D021382:Protein Sorting Signals; D045522:Recombinases