title: [Endothelial dysfunction and nonspecific immune reactions in development and progression of osteoarthrosis in women engaged into manual work].
abstract: The article considers mechanisms of development and progression of osteoarthrosis as an occupationally conditioned disease in women of manual work. Women working in physical overstrain conditions are under occupational risk with dysfunction of many body systems. The authors set a hypothesis on association of endothelial dysfunction markers dysbalance and structural remodelling of cartilage matrix as a proof of degenerative changes.
authors.forename: N N
authors.initials: NN
authors.lastname: Maliutina
authors.forename: M S
authors.initials: MS
authors.lastname: Nevzorova
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D056724:Immunity, Humoral; D009569:Nitric Oxide / Q000097:blood; D009784:Occupational Diseases / Q000097:blood / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D016273:Occupational Exposure / Q000032:analysis; D010003:Osteoarthritis / Q000097:blood / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000097:blood; D016526:Workload; D017132:Workplace / Q000592:standards*
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D009569:Nitric Oxide; D002097:C-Reactive Protein