title: Silver(I) as a widely applicable, homogeneous catalyst for aerobic oxidation of aldehydes toward carboxylic acids in water-"silver mirror": From stoichiometric to catalytic.
abstract: The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids in extremely high yields. The reaction conditions are very mild and greener, requiring only a very low silver(I) catalyst loading, using atmospheric oxygen as the oxidant and water as the solvent, and allowing gram-scale oxidation with only 2 mg of our catalyst. Chromatography is completely unnecessary for purification in most cases.
authors.affiliation: Department of Chemistry and FRQNT Centre in Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Mingxin
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Chemistry and FRQNT Centre in Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Haining
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemistry and FRQNT Centre in Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Huiying
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Department of Chemistry and FRQNT Centre in Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Li
keywords: aerobic oxidation; aldehyde oxidation; oxygen activation; reactions in water; silver catalysis