title: Plutonium-DTPA Model Application with USTUR Case 0269.
abstract: A plutonium-DTPA (Pu-DTPA) biokinetic model was introduced that had originated from the study of a plutonium-contaminated wound. This work evaluated the extension of the Pu-DTPA model to United States Transuranium and Uranium Registry (USTUR) Case 0269 involving an acute inhalation of a plutonium nitrate aerosol. Chelation was administered intermittently for the first 7 mo as Ca-EDTA, mostly through intravenous injection, with Ca-DTPA treatments administered approximately 2.5 y post intake. Urine and fecal bioassays were collected following intake for several years. Tissues were collected and analyzed for plutonium content approximately 38 y post intake. This work employed the Pu-DTPA model for predicting the urine and fecal bioassay and final tissue quantity at autopsy. The Pu-DTPA model was integrated with two separate plutonium systemic models (i.e., ICRP Publication 67 and its proposed modification). This work illustrated that the Pu-DTPA model was useful for predicting urine and fecal bioassay, including final tissue quantity, 38 y post intake.
authors.affiliation: *Department of Nuclear Engineering and Health Physics, Idaho State University, 921 South 8th Avenue, Stop 8060, Pocatello, ID 83209-8060; †Division of Radiobiology, School of Medicine, University of Utah, Salt Lake City, UT 84108.
authors.forename: Kevin
authors.initials: K
authors.lastname: Konzen
authors.forename: Richard
authors.initials: R
authors.lastname: Brey
authors.forename: Scott
authors.initials: S
authors.lastname: Miller
mesh_terms: D000336:Aerosols; D001344:Autopsy; D001681:Biological Assay; D001842:Bone and Bones / Q000737:chemistry* / Q000187:drug effects / Q000528:radiation effects; D002614:Chelating Agents / Q000008:administration & dosage; D005243:Feces / Q000737:chemistry; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000737:chemistry* / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008954:Models, Biological; D009566:Nitrates / Q000493:pharmacokinetics* / Q000506:poisoning* / Q000652:urine; D004369:Pentetic Acid / Q000008:administration & dosage*; D011005:Plutonium / Q000493:pharmacokinetics* / Q000506:poisoning* / Q000652:urine; D011832:Radiation Injuries / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness; D014018:Tissue Distribution; D014481:United States
chemical_list: D000336:Aerosols; D002614:Chelating Agents; D009566:Nitrates; D011837:Radiation-Protective Agents; C015459:plutonium nitrate; D011005:Plutonium; D004369:Pentetic Acid