title: Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease.
abstract: Peripheral vascular disease (PVD) is a progressive atherosclerotic disease that leads to stenosis or occlusion of blood vessels supplying the lower extremities. Current diagnostic imaging techniques commonly focus on evaluation of anatomy or blood flow at the macrovascular level and do not permit assessment of the underlying pathophysiology associated with disease progression or treatment response. Molecular imaging with radionuclide-based approaches can offer novel insight into PVD by providing noninvasive assessment of biological processes such as angiogenesis and atherosclerosis. This article discusses emerging radionuclide-based imaging approaches that have potential clinical applications in the evaluation of PVD progression and treatment.
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, PO Box 208017, Dana-3, New Haven, CT 06520, USA. Electronic address: mitchel.stacy@yale.edu.
authors.forename: Mitchel R
authors.initials: MR
authors.lastname: Stacy
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, PO Box 208017, Dana-3, New Haven, CT 06520, USA; Department of Diagnostic Radiology, Yale University School of Medicine, PO Box 208042, New Haven, CT 06520, USA.
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Sinusas
mesh_terms: D006801:Humans; D064847:Multimodal Imaging; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals
keywords: Angiogenesis; Atherosclerosis; Molecular imaging; PET; Perfusion; Peripheral vascular disease; SPECT