title: What is myeloperoxidase doing in ANCA-associated glomerulonephritis?
abstract: O'Sullivan et al. describe glomerular localization of myeloperoxidase (MPO) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and correlate the amount of deposition with severity of injury. MPO is the antigen against which anti-MPO ANCAs are directed, the antigen to which pathogenic T cells that can induce antibody-independent AAV are directed, and MPO can induce glomerular injury directly by interacting with H2O2 and a halide to halogenate glomerular structures. All three of these roles are likely involved in human disease.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Washington, Woodinville, Washington, USA.
authors.forename: William G
authors.initials: WG
authors.lastname: Couser
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, University of Colorado, Aurora, Colorado, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Johnson
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000276:immunology; D019268:Antibodies, Antineutrophil Cytoplasmic; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D006861:Hydrogen Peroxide; D009195:Peroxidase / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D006861:Hydrogen Peroxide; D009195:Peroxidase