title: Contact Lens Corneal Inflammatory Events in a University Population.
abstract: OBJECTIVE
  To identify the contact lens-related modifiable and nonmodifiable factors associated with corneal inflammatory events (CIEs) in a university eye care center.
  
  
  METHODS
  Contact lens-wearing undergraduate and graduate/professional students (age range, 18 to 36 years) with CIEs and contact lens wearers without complications (non-CIEs) were surveyed about their age, education level, overnight wear, brand of lens, brand of care solution, storage case age, topping-off, and lens replacement. Logistic regression was used to assess the impact of participant characteristics (demographic and behavior) and contact lens factors on the risk of a CIE.
  
  
  RESULTS
  There were 160 participants enrolled, with 76 presenting with a CIE. Age was significant in the multivariate model (p < 0.001) as was an interaction between disinfectant and wearing schedule (p = 0.027). When daily wear (DW) and disinfectant were compared, polyquaternium-1/myristamidopropyl dimethylamine (PQ-1/MAPD) was associated with a greater risk of CIE versus peroxide (adjusted odds ratio [aOR], 18.4; 95% confidence interval [95% CI], 1.9-173.9) and versus polyhexamethylene biguanide or polyaminopropyl biguanide (PHMB) (aOR, 15.0; 95% CI, 4.5-50.0). For PHMB users only, extended wear (EW) compared with DW increased CIE risk (aOR, 10.0; 95% CI, 2.0-51.2). There was no difference in risk between EW and DW for PQ-1/MAPD (aOR, 0.8; 95% CI, 0.2, 2.6).
  
  
  CONCLUSIONS
  The multivariate analysis suggests that younger age and the use of PQ-1/MAPD, particularly in DW, increase the risk of acquiring a CIE with soft contact lens wear in college-aged students. For PHMB users, EW compared with DW increases the risk of a CIE; but for PQ-1/MAPD users, there is no difference between EW and DW.
authors.affiliation: *OD, MS, FAAO †OD, FAAO ‡MAS, FAAO The Ohio State University College of Optometry, Columbus, Ohio (ABZ, JG, GJN, GLM); and Archbold Eye Care, Archbold, Ohio (AJE).
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Zimmerman
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Emch
authors.forename: Julia
authors.initials: J
authors.lastname: Geldis
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Nixon
authors.forename: G Lynn
authors.initials: GL
authors.lastname: Mitchell
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001645:Biguanides / Q000009:adverse effects; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D004202:Disinfectants / Q000009:adverse effects; D004209:Disposable Equipment; D005260:Female; D006801:Humans; D007634:Keratitis / Q000209:etiology*; D008297:Male; D016017:Odds Ratio; D011108:Polymers / Q000009:adverse effects; D011437:Propylamines / Q000009:adverse effects; D011446:Prospective Studies; D012307:Risk Factors; D014495:Universities; D055815:Young Adult
chemical_list: D001645:Biguanides; D004202:Disinfectants; D011108:Polymers; D011437:Propylamines; C064420:polyaminopropylbiguanide; C031233:polihexanide; C058655:polyquaternium 1; C401661:myristamidopropyl dimethylamine