title: Unconventional Functions of Mitotic Kinases in Kidney Tumorigenesis.
abstract: Human tumors exhibit a variety of genetic alterations, including point mutations, translocations, gene amplifications and deletions, as well as aneuploid chromosome numbers. For carcinomas, aneuploidy is associated with poor patient outcome for a large variety of tumor types, including breast, colon, and renal cell carcinoma. The Renal cell carcinoma (RCC) is a heterogeneous carcinoma consisting of different histologic types. The clear renal cell carcinoma (ccRCC) is the most common subtype and represents 85% of the RCC. Central to the biology of the ccRCC is the loss of function of the Von Hippel-Lindau gene, but is also associated with genetic instability that could be caused by abrogation of the cell cycle mitotic spindle checkpoint and may involve the Aurora kinases, which regulate centrosome maturation. Aneuploidy can also result from the loss of cell-cell adhesion and apical-basal cell polarity that also may be regulated by the mitotic kinases (polo-like kinase 1, casein kinase 2, doublecortin-like kinase 1, and Aurora kinases). In this review, we describe the "non-mitotic" unconventional functions of these kinases in renal tumorigenesis.
authors.affiliation: UMR 6290 (IGDR), CNRS, University Rennes-1 , Rennes , France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Hascoet
authors.affiliation: UMR 6290 (IGDR), CNRS, University Rennes-1 , Rennes , France.
authors.forename: Franck
authors.initials: F
authors.lastname: Chesnel
authors.affiliation: UMR 6290 (IGDR), CNRS, University Rennes-1 , Rennes , France.
authors.forename: Cathy
authors.initials: C
authors.lastname: Le Goff
authors.affiliation: UMR 6290 (IGDR), CNRS, University Rennes-1 , Rennes , France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Le Goff
authors.affiliation: UMR 6290 (IGDR), CNRS, University Rennes-1 , Rennes , France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Arlot-Bonnemains
keywords: Aurora-A kinase; kidney; mitotic kinases; non-mitotic functions; tumorigenesis