title: Cervical cancer stem cells.
abstract: The concept of cancer stem cells (CSC) has been established over the past decade or so, and their role in carcinogenic processes has been confirmed. In this review, we focus on cervical CSCs, including (1) their purported origin, (2) markers used for cervical CSC identification, (3) alterations to signalling pathways in cervical cancer and (4) the cancer stem cell niche. Although cervical CSCs have not yet been definitively identified and characterized, future studies pursuing them as therapeutic targets may provide novel insights for treatment of cervical cancer.
authors.affiliation: Department of Gynecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.|Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Yao
authors.affiliation: Department of Dermatology and Venereology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China.
authors.forename: Rongbiao
authors.initials: R
authors.lastname: Lu
authors.affiliation: Department of Clinical Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Yizhen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Clinical Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Clinical Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Chenyang
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Gynecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Rongchun
authors.initials: R
authors.lastname: Lin
authors.affiliation: Department of Gynecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Zhongqiu
authors.initials: Z
authors.lastname: Lin
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002584:Cervix Uteri / Q000166:cytology / Q000473:pathology*; D005260:Female; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*; D027383:Papillomaviridae; D015398:Signal Transduction; D055153:Stem Cell Niche / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology
chemical_list: D014408:Biomarkers, Tumor