title: Effects of Prednisolone, L-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas.
abstract: The aim of this study is to determine the effects of L-asparaginase (L-ASP), corticosteroids (CSs), and antilipidemics, separately and in combination, on the lipid profiles and the liver and pancreas histology in mice. This study included 8 groups of 7 mice each. Before any drug administration, serum samples were taken from all of the mice. Then, normal saline was applied to the control group, and a medication or combination of medications was applied to the other groups. Levels of triglycerides, cholesterol (COL), and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined, and the livers and pancreases were evaluated histologically at the end of the study. Triglycerides increased significantly in the CS-only and the L-ASP-only groups, COL increased significantly in the CS-only group, and HDL increased significantly in the CS-only and the antilipidemic-only groups. LDL was significantly lower in the CS-only and the L-ASP-only groups. CSs and L-ASP were significantly effective in liver necrosis, L-ASP was significantly effective in liver balloon degeneration, and CS were significantly effective in pancreas vacuolization. Triglyceride measurement is recommended before/during CS and/or L-ASP treatment. Starting with an antilipidemic agent can be considered to avoid possible complications in patients with significantly high rates. Indicators of a possible liver or pancreas injury should also be considered.
authors.affiliation: Departments of *Pediatric Hematology and Oncology ‡Pathology §Biochemistry ∥Pediatric Endocrinology, Faculty of Medicine, Selcuk University †Department of Neonatology, Faculty of Medicine #Department of Pediatric Hematology and Oncology, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Dogan
authors.initials: D
authors.lastname: Kose
authors.forename: Nuriye
authors.initials: N
authors.lastname: Tarakci
authors.forename: Zeliha Esin
authors.initials: ZE
authors.lastname: Celik
authors.forename: Husamettin
authors.initials: H
authors.lastname: Vatansev
authors.forename: Emine Ayca
authors.initials: EA
authors.lastname: Cimbek
authors.forename: Serdar
authors.initials: S
authors.lastname: Ugras
authors.forename: Yasar
authors.initials: Y
authors.lastname: Sen
authors.forename: Umran
authors.initials: U
authors.lastname: Caliskan
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Koksal
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001215:Asparaginase / Q000009:adverse effects; D004338:Drug Combinations; D005260:Female; D015248:Gemfibrozil / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D020799:Pancrelipase / Q000187:drug effects*; D011239:Prednisolone / Q000009:adverse effects
chemical_list: D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D004338:Drug Combinations; D000960:Hypolipidemic Agents; D008055:Lipids; D020799:Pancrelipase; D011239:Prednisolone; D001215:Asparaginase; D015248:Gemfibrozil