title: Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D.
abstract: Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other immunomodulatory therapies in murine tumor models.
authors.affiliation: Vaccinex, Inc. ; Rochester, NY USA.
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Evans
authors.affiliation: Vaccinex, Inc. ; Rochester, NY USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Paris
authors.affiliation: Vaccinex, Inc. ; Rochester, NY USA.
authors.forename: Ernest S
authors.initials: ES
authors.lastname: Smith
authors.affiliation: Vaccinex, Inc. ; Rochester, NY USA.
authors.forename: Maurice
authors.initials: M
authors.lastname: Zauderer
keywords: CTL; Plexin; immune checkpoint blockade; invasive margin; semaphorin; tumor associated macrophage; tumor rejection; tumor stroma.