title: Feasibility Study of Respiratory Motion Modeling Based Correction for MRI-Guided Intracardiac Interventional Procedures.
abstract: OBJECTIVE
  The purpose of this study is to improve the accuracy of interventional catheter guidance during intracardiac procedures. Specifically, the use of preprocedural magnetic resonance roadmap images for interventional guidance has limited anatomical accuracy due to intraprocedural respiratory motion of the heart. Therefore, we propose to build a novel respiratory motion model to compensate for this motion-induced error during magnetic resonance imaging (MRI)-guided procedures.
  
  
  METHODS
  We acquire 2-D real-time free-breathing images to characterize the respiratory motion, and build a smooth motion model via registration of 3-D prior roadmap images to the real-time images within a novel principal axes frame of reference. The model is subsequently used to correct the interventional catheter positions with respect to the anatomy of the heart.
  
  
  RESULTS
  We demonstrate that the proposed modeling framework can lead to smoother motion models, and potentially lead to more accurate motion estimates. Specifically, MRI-guided intracardiac ablations were performed in six preclinical animal experiments. Then, from retrospective analysis, the proposed motion modeling technique showed the potential to achieve a 27% improvement in ablation targeting accuracy.
  
  
  CONCLUSIONS
  The feasibility of a respiratory motion model-based correction framework has been successfully demonstrated.
  
  
  CONCLUSIONS
  The improvement in ablation accuracy may lead to significant improvements in success rate and patient outcomes for MRI-guided intracardiac procedures.
authors.forename: Robert
authors.initials: R
authors.lastname: Xu
authors.forename: Prashant
authors.initials: P
authors.lastname: Athavale
authors.forename: Philippa
authors.initials: P
authors.lastname: Krahn
authors.forename: Kevan
authors.initials: K
authors.lastname: Anderson
authors.forename: Jennifer
authors.initials: J
authors.lastname: Barry
authors.forename: Labonny
authors.initials: L
authors.lastname: Biswas
authors.forename: Venkat
authors.initials: V
authors.lastname: Ramanan
authors.forename: Nicolas
authors.initials: N
authors.lastname: Yak
authors.forename: Mihaela
authors.initials: M
authors.lastname: Pop
authors.forename: Graham A
authors.initials: GA
authors.lastname: Wright
mesh_terms: D000465:Algorithms; D000818:Animals; D006348:Cardiac Surgical Procedures / Q000379:methods*; D004867:Equipment Design; D005240:Feasibility Studies; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008954:Models, Biological; D009068:Movement / Q000502:physiology*; D012119:Respiration; D025321:Surgery, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D013552:Swine