title: [Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress].
abstract: OBJECTIVE
  The purpose of this study was to examine the mediation of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life in order to provide a basis for planning nursing interventions to improve the quality of life in cancer patients.
  
  
  METHODS
  A purposive sample of 130 patients treated with chemotherapy were recruited in the cross-sectional survey design. Data were collected using self-report questionnaires. The instruments were the Chemotherapy Induced Peripheral Neuropathy Assessment Tool (CIPNAT), Hospital Anxiety Depression Scale (HADS), and Functional Assessment of Cancer Therapy-General (FACT-G).
  
  
  RESULTS
  The mean score for disturbance in ADL from chemotherapy induced peripheral neuropathy was 3.30. Overall quality of life was 2.48. The mean score was 1.04 for psychological distress. The prevalence was 35.4% for anxiety and 47.7% for depression. There were significant correlations among the three variables, disturbance in ADL from chemotherapy induced peripheral neuropathy, psychosocial distress, and quality of life. Psychosocial distress had a complete mediating effect (β=-.74, p<.001) in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life (Sobel test: Z=-6.11, p<.001).
  
  
  CONCLUSIONS
  Based on the findings of this study, nursing intervention programs focusing on disturbance of ADL management, and decrease of psychological distress are highly recommended to improve quality of life in cancer patients.
authors.affiliation: Korea Institude of Radiological & Medical Science, Seoul, Korea.
authors.forename: Kyung Yeon
authors.initials: KY
authors.lastname: Kim
authors.affiliation: Korea Institude of Radiological & Medical Science, Seoul, Korea.
authors.forename: Seung Hee
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Clinical Nursing, University of Ulsan, Seoul, Korea.
authors.forename: Jeong Hye
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Nursing, Sahmyook University, Seoul, Korea. ohpj@syu.ac.kr.
authors.forename: Pok Ja
authors.initials: PJ
authors.lastname: Oh
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001007:Anxiety; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000523:psychology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D011788:Quality of Life; D057566:Self Report; D013315:Stress, Psychological; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents
keywords: Depression; Neoplasm; Peripheral neuropathy; Quality of life