title: Dietary exposure of acrylamide from the fifth Chinese Total Diet Study.
abstract: The levels of acrylamide in 240 food composite samples from the 5th Chinese Total Diet Study (TDS) were measured using an LC-MS/MS method and the exposure estimates for the general population were evaluated. The samples were collected from 20 provinces in China, covering about two thirds of the Chinese population. Acrylamide was detected in 40.0% of composite samples with the concentrations ranged from 0.8 to 211.8 μg/kg. The average dietary intakes from the 5th Chinese TDS were 0.319 μg kg(-1) bw day(-1) and an increase with about 70% was observed from the 3rd Chinese TDS in 2000 to the 5th Chinese TDS between 2009 and 2012. The main food group contributors to acrylamide exposure were vegetables (35.2%), cereals (34.3%) and potatoes (15.7%). Based on the benchmark dose lower confidence limit at 10% risk (BMDL10) of 0.31 mg kg(-1) bw day(-1) for the induction of mammary tumors in rats and 0.18 mg kg(-1) bw day(-1) for Harderian gland tumors in mice, the margins of exposure (MOEs) were 973 and 565 for Chinese general population, respectively. These MOEs indicate a human health concern.
authors.affiliation: The Key Laboratory of Food Safety Risk Assessment, Ministry of Health, and China National Center for Food Safety Risk Assessment, 7 Panjiayuannanli, Beijing 100021, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.affiliation: The Key Laboratory of Food Safety Risk Assessment, Ministry of Health, and China National Center for Food Safety Risk Assessment, 7 Panjiayuannanli, Beijing 100021, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Jiangsu Province Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Jiangsu Province Center for Disease Control and Prevention, Nanjing 210009, China.
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Ma
authors.affiliation: The Key Laboratory of Food Safety Risk Assessment, Ministry of Health, and China National Center for Food Safety Risk Assessment, 7 Panjiayuannanli, Beijing 100021, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Li
authors.affiliation: The Key Laboratory of Food Safety Risk Assessment, Ministry of Health, and China National Center for Food Safety Risk Assessment, 7 Panjiayuannanli, Beijing 100021, China. Electronic address: miaohong0827@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Miao
authors.affiliation: The Key Laboratory of Food Safety Risk Assessment, Ministry of Health, and China National Center for Food Safety Risk Assessment, 7 Panjiayuannanli, Beijing 100021, China.
authors.forename: Yongning
authors.initials: Y
authors.lastname: Wu
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D002681:China; D004032:Diet; D004781:Environmental Exposure / Q000032:analysis; D004785:Environmental Pollutants / Q000737:chemistry*; D005247:Feeding Behavior; D005502:Food / Q000145:classification; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis* / Q000706:statistics & numerical data; D006801:Humans; D018570:Risk Assessment
chemical_list: D004785:Environmental Pollutants; D020106:Acrylamide
keywords: Acrylamide; China; Dietary exposure; Risk assessment; Total Diet Study