title: Fractal dimensions: A new paradigm to assess spatial memory and learning using Morris water maze.
abstract: Morris water maze has been widely used for analysis of cognitive functions and relies on the time taken by animal to find the platform i.e. escape latency as a parameter to quantify spatial memory and learning. However, escape latency is confounded by swimming speed which is not necessarily a cognitive factor. Rather, path length may be a more appropriate and reliable parameter to assess spatial learning. This paper presents fractal dimension as a new paradigm to assess spatial memory and learning in animals. Male wistar rats were administrated with pentylenetetrazole and scopolamine to induce chronic epilepsy and dementia respectively. Fractal dimension of the random path followed by the animals on Morris water maze was analyzed and statistically compared among different experimental groups; the results suggest that fractal dimension is more reliable and accurate parameter to assess cognitive deficits compared to escape latency. Thus, the present study suggests that fractal dimensions could be used as an independent parameter to assess spatial memory and learning in animals using Morris water maze.
authors.affiliation: Department of Governance Reforms, Government of Punjab, India.
authors.forename: Surjeet
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, Panjab University, Sector-25, Chandigarh 160014, India.
authors.forename: Harpreet
authors.initials: H
authors.lastname: Kaur
authors.affiliation: Department of Biochemistry, Panjab University, Sector-25, Chandigarh 160014, India. Electronic address: sandhir@pu.ac.in.
authors.forename: Rajat
authors.initials: R
authors.lastname: Sandhir
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D003071:Cognition; D003072:Cognition Disorders; D003704:Dementia / Q000139:chemically induced / Q000523:psychology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000523:psychology; D017709:Fractals; D008297:Male; D018782:Maze Learning; D051381:Rats; D017208:Rats, Wistar; D065852:Spatial Memory / Q000502:physiology*; D013550:Swimming; D014867:Water
chemical_list: D014867:Water
keywords: Behaviour; Cognition; Fractal dimension; Memory; Morris water maze; Rodents