title: Flushing Out Carcinoid Syndrome: Beneficial Effect of the Anticancer Epigenetic Agent RRx-001 in a Patient with a Treatment-Refractory Neuroendocrine Tumor.
abstract: Neuroendocrine tumors (NET) are a heterogeneous group of neoplasms defined by the presence of cells with secretory granules and the potential to produce and release high levels of vasoactive peptides into the circulation, leading to severe flushing and diarrhea, which may adversely affect quality of life. This report presents the case of a 64-year-old man with chronic refractory diarrhea due to pulmonary NET treated with the experimental anticancer agent RRx-001 in a phase II trial called TRIPLE THREAT with subsequent resolution of his diarrhea.
authors.affiliation: Walter Reed National Military Medical Center, Bethesda, Md., USA.
authors.forename: Corey A
authors.initials: CA
authors.lastname: Carter
authors.affiliation: Walter Reed National Military Medical Center, Bethesda, Md., USA.
authors.forename: Aiste
authors.initials: A
authors.lastname: Degesys
authors.affiliation: EpicentRx, Inc., Mountain View, Calif., USA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Oronsky
authors.affiliation: EpicentRx, Inc., Mountain View, Calif., USA.
authors.forename: Jan
authors.initials: J
authors.lastname: Scicinski
authors.affiliation: EpicentRx, Inc., Mountain View, Calif., USA.
authors.forename: Scott Z
authors.initials: SZ
authors.lastname: Caroen
authors.affiliation: InterWest Partners, Menlo Park, Calif., USA.
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Oronsky
authors.affiliation: Moores Cancer Center, University of California, La Jolla, Calif., USA.
authors.forename: Tony
authors.initials: T
authors.lastname: Reid
authors.affiliation: Department of Bioengineering, University of California, La Jolla, Calif., USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Cabrales
authors.affiliation: Walter Reed National Military Medical Center, Bethesda, Md., USA.
authors.forename: Joe
authors.initials: J
authors.lastname: Roswarski
keywords: Carcinoid syndrome; Epigenetics; Neuroendocrine tumor