title: Fragility fracture risk and skeletal muscle function.
abstract: Low-intensity fractures are closely related with age-related musculoskeletal disorders, including osteoporosis, muscle dysfunction and sarcopenia, age-related chronic diseases, and pharmacological treatments. During the last years, a huge amount of information and recommendations has been released in relation to bone metabolism and mineral content. Muscle dysfunction and sarcopenia are highly prevalent during the second half of life, especially in older subjects. The development of sarcopenia may be slowed through healthy lifestyle changes, which include adequate dietary protein, vitamin D and mineral intakes, and regular physical activity. Prevention of falls should be integral, including correction in major involved factors in order to reduce fragility fracture, improve quality of life and appropriately focus clinical and economic resources. Therefore, to obtain better results a global approach is needed to prevent age-related fractures in frail patients that is not only centered on bone metabolism and antiresorptive drugs.
authors.affiliation: a Department of Obstetrics and Gynecology , University of Zaragoza and Lozano-Blesa University Hospital, Domingo Miral s/n , Zaragoza , Spain ;
authors.forename: F R
authors.initials: FR
authors.lastname: Pérez-López
authors.affiliation: b Growth, Exercise, Nutrition and Development (GENUD) Toledo Research Group , Universidad de Castilla-La Mancha , Toledo , Spain.
authors.forename: I
authors.initials: I
authors.lastname: Ara
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control*; D000368:Aged; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D050723:Fractures, Bone / Q000517:prevention & control*; D006801:Humans; D008019:Life Style; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010024:Osteoporosis / Q000188:drug therapy*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D055948:Sarcopenia / Q000503:physiopathology* / Q000628:therapy; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D050071:Bone Density Conservation Agents; D014807:Vitamin D
keywords: Osteoporosis; falls; fractures; lifestyle; muscle function; sarcopenia; vitamin D