title: Brief Report: Enhanced Allogeneic Cellular Responses to Mismatched HLA-B Antigens Results in More Efficient Killing of HIV Infected Cells.
abstract: Epidemiologic studies have demonstrated that HIV-1 discordant couples who share HLA-B alleles were more likely to transmit HIV-1. These data lead us to hypothesize that individuals who match at both HLA-B alleles should have a reduced allogeneic response than those who are not matched. We observed diminished killing of CD4 target cells only when HLA-B alleles were matched. We propose that for cell-associated HIV-1 transmission, the ability of the recipient to eliminate infected cells from a donor partner may be enhanced when HLA-B alleles are different between partners. These findings suggest a novel mechanism for protection against HIV infection.
authors.affiliation: Departments of *Medicine; †Microbiology, University of Alabama at Birmingham, Birmingham, AL; and ‡Emory Vaccine Center at Yerkes National Primate Research Center and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA.
authors.forename: Steffanie
authors.initials: S
authors.lastname: Sabbaj
authors.forename: Nicholas
authors.initials: N
authors.lastname: Scanlon
authors.forename: Victor Y
authors.initials: VY
authors.lastname: Du
authors.forename: Yuge
authors.initials: Y
authors.lastname: Wang
authors.forename: Jianming
authors.initials: J
authors.lastname: Tang
authors.forename: Eric
authors.initials: E
authors.lastname: Hunter
authors.forename: Paul A
authors.initials: PA
authors.lastname: Goepfert
mesh_terms: D000483:Alleles; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016923:Cell Death / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics / Q000276:immunology* / Q000635:transmission*; D015497:HIV-1; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D012747:Sexual Partners
chemical_list: D015235:HLA-B Antigens