title: Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53.
abstract: Diversity-oriented construction of new indolizine scaffolds was accomplished by utilizing domino Knoevenagel condensation/intramolecular aldol cyclization. Biological evaluation revealed anticancer activity of these compounds through inhibition of β-catenin and activation of p53.
authors.affiliation: Laboratory of Translational Therapeutics, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
authors.forename: Seong-Hee
authors.initials: SH
authors.lastname: Moon
authors.affiliation: College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea.
authors.forename: Youngeun
authors.initials: Y
authors.lastname: Jung
authors.affiliation: Laboratory of Translational Therapeutics, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea. Electronic address: hwan@krict.re.kr.
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea. Electronic address: ikyonkim@yonsei.ac.kr.
authors.forename: Ikyon
authors.initials: I
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007212:Indolizines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D016159:Tumor Suppressor Protein p53 / Q000819:agonists* / Q000378:metabolism; D051176:beta Catenin / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D007212:Indolizines; D016159:Tumor Suppressor Protein p53; D051176:beta Catenin; C035094:indolizine
keywords: Anticancer activity; Diversity-oriented synthesis; Indolizine; p53; β-Catenin