title: Multidimensional nanofibrous scaffolds of poly(lactide-co-caprolactone) and poly(ethyl oxazoline) with improved features for cardiac tissue engineering.
abstract: OBJECTIVE
  The aim of the study is to develop scaffolds that mimic native tissue properties for effective regeneration of the myocardium, which is affected by the gradual thinning of left ventricular tissue after an infarction.
  
  
  METHODS
  Heterogenous nanofibrous scaffolds made of poly(lactide-co-caprolactone) and poly(ethyl oxazoline) were characterized for physico-chemical properties. The biocompatibility of the scaffolds was evaluated by studying the adhesion, proliferation and differentiation of H9c2 cells.
  
  
  RESULTS
  The scaffolds mimic the cardiac extracellular matrix and showed enhanced tensile strength, improved cell compatibility along with the expression of cardiac marker proteins.
  
  
  CONCLUSIONS
  Our experimental data confirmed the importance of native tissue architecture and mechanical strength for improved cell response in cardiac tissue engineering.
authors.affiliation: Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA University, Thanjavur - 613 401, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Lakshmanan
authors.affiliation: Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA University, Thanjavur - 613 401, India.
authors.forename: Uma Maheswari
authors.initials: UM
authors.lastname: Krishnan
authors.affiliation: Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA University, Thanjavur - 613 401, India.
authors.forename: Swaminathan
authors.initials: S
authors.lastname: Sethuraman
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002208:Caproates / Q000737:chemistry; D002460:Cell Line; D006801:Humans; D007783:Lactones / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D002208:Caproates; D007783:Lactones; C121056:caprolactone
keywords: cardiac tissue engineering; mechanical strength; nanofibers; physical blends; poly(ethyl oxazoline)