title: Clinical Improvement and Safety of Ablative Fractional Laser Therapy for Post-Surgical Scars: A Systematic Review of Randomized Controlled Trials.
abstract: BACKGROUND
  Ablative fractional laser (AFL) therapy for scars is an area of increasing interest. While the enthusiasm for these treatments is high, a systematic review of their use on surgical scars has not been done.
  
  
  OBJECTIVE
  To identify randomized trials that study the efficacy of ablative fractionated laser therapy for treatment of surgical scars.
  
  
  METHODS
  EMBASE, Web of Science, and Pubmed databases were searched for randomized trials with 10 or more surgical wounds. No restrictions were placed on the language of the publications.
  
  
  RESULTS
  Three randomized trials were identified that met the criteria for the review. One study found superior efficacy of ablative fractionated laser treatment of surgical scars compared to pulsed dye laser while the others found equivalent efficacy when compared to dermabrasion or pulsed dye laser. One study found a superior safety profile for ablative fractionated laser treatment over dermabrasion. No studies compared fractionated laser therapy to sham therapy or observation.
  
  
  CONCLUSIONS
  AFL compares well with the scar amelioration techniques of dermabrasion and pulsed dye laser. Additional studies are needed to further contrast AFL to these and other modalities as well as to observation alone.
authors.forename: Trenton
authors.initials: T
authors.lastname: Custis
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Eisen
mesh_terms: D002921:Cicatrix / Q000209:etiology / Q000628:therapy*; D003869:Dermabrasion / Q000009:adverse effects / Q000379:methods; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D054025:Lasers, Dye / Q000009:adverse effects / Q000627:therapeutic use; D011183:Postoperative Complications / Q000473:pathology / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic