title: Respiratory allergies in childhood: Recent advances and future challenges.
abstract: The burden of allergic airway diseases still represents a major health problem in childhood. Despite many different options are currently available for the diagnostic work-up and management, the overall disease control in terms of impact on quality of life, morbidity and mortality, is not yet satisfactory. The extreme variability of individual risk factors and severity determinants may account for it. On the other side, the knowledge of the multifaceted allergy background could pave the way to primary prevention, early intervention and disease course modification. In fact, most of current research is focusing on the identification of biological and clinical predictive markers of allergy and asthma onset. This review aims at summarizing the latest achievements concerning the complex inter-relation between genetic predisposition and environmental factors, and their impact on prevention strategies and early identification of at risk subjects. An update on the diagnostic and monitoring tools as well as an insight into the newest treatments options is also provided.
authors.affiliation: Allergy Unit, Verona University and General Hospital, Verona, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Caminati
authors.affiliation: Department of Immunology, Faculty of Medical Science Kragujevac, Kragujevac, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Durić-Filipović
authors.affiliation: Allergy Unit, Department of Pediatrics, University of Messina, Messina, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Arasi
authors.affiliation: Department of Pediatrics, University of Ferrara, Ferrara, Italy.|International Inflammation (in-FLAME) Network of the World Universities Network, Ferrara, Italy.
authors.forename: Diego G
authors.initials: DG
authors.lastname: Peroni
authors.affiliation: Children's Hospital for Lung Diseases and Tuberculosis, Medical Center 'Dr Dragisa Misovic', Belgrade, Serbia.|Faculty of Pharmacy, European University, Novi Sad, Serbia.
authors.forename: Zorica
authors.initials: Z
authors.lastname: Živković
authors.affiliation: Allergy Unit, Verona University and General Hospital, Verona, Italy.
authors.forename: Gianenrico
authors.initials: G
authors.lastname: Senna
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D035843:Biomedical Research; D002648:Child; D042241:Early Diagnosis; D059647:Gene-Environment Interaction; D006801:Humans; D011379:Prognosis; D012130:Respiratory Hypersensitivity / Q000175:diagnosis* / Q000628:therapy; D012307:Risk Factors
chemical_list: D015415:Biomarkers
keywords: airway; allergy; biomarkers; childhood; diagnostics; environment; life quality; prediction; risk factors; therapy