title: Longitudinal study of children with perinatal brain damage in whom early neurohabilitation was applied: Preliminary report.
abstract: OBJECTIVE
  The neurohabilitation treatment has been shown to be a successful method for decreasing the sequelae of perinatal brain damage (PBD) in Hungarian population. The goal of this pilot trial was to introduce this procedure by describing the results of its application in infants with PBD as demonstrated by clinical, developmental and MRI studies. As this procedure has proved to be useful, according the declaration of Helsinki, no control clinical trial was permitted.
  
  
  METHODS
  Infants younger than 2 months of corrected age (CA) with prenatal and/or perinatal risk factors for brain damage. Two groups were considered. One group was treated using the "neurohabilitation" method (n=20), and the other was not treated (n=13) because treatment was voluntarily discontinued after the initial evaluation. Evaluations were carried out prior to 2 months of CA and at 6-8 years of age. All children showed abnormal clinical and MRI characteristics in the first study.
  
  
  RESULTS
  The treated group had a higher percentage (90%) of children with normal outcome than did the non-treated group (38%; OR=2.37, CI 95%=1.2-4.7; p<0.005). In this latter group, only one out of five (20%) children born at or before 34 weeks of gestational age had a normal outcome. In contrast, eight out of nine treated preterm infants had normal outcomes (8/9=89%, OR=4.45, CI 95%=0.7-26; p=0.017).
  
  
  CONCLUSIONS
  This pilot trial confirms previous studies suggesting that Neurohabilitation decreases the neurological and cognitive sequelae of preterm and at-term infants with PBD.
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico. Electronic address: thaliah@unam.mx.
authors.forename: Thalía
authors.initials: T
authors.lastname: Harmony
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
authors.forename: Jesús
authors.initials: J
authors.lastname: Barrera-Reséndiz
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Juárez-Colín
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
authors.forename: Cristina
authors.initials: C
authors.lastname: Carrillo-Prado
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
authors.forename: M del Consuelo
authors.initials: MC
authors.lastname: Pedraza-Aguilar
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
authors.forename: Aurora
authors.initials: A
authors.lastname: Asprón Ramírez
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
authors.forename: Manuel
authors.initials: M
authors.lastname: Hinojosa-Rodríguez
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
authors.forename: Thalía
authors.initials: T
authors.lastname: Fernández
authors.affiliation: Unidad de Investigación en Neurodesarrollo, Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Mexico.
authors.forename: Josefina
authors.initials: J
authors.lastname: Ricardo-Garcell
mesh_terms: D001921:Brain / Q000254:growth & development / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008124:Locomotion; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D010865:Pilot Projects; D016138:Walking
keywords: Hypoxic ischemic encephalopathy; MRI; Neurohabilitation; Perinatal brain damage; Prenatal risk factors; Preterm encephalopathy