title: Lung cancer screening and management.
abstract: Deaths from lung cancer are greater than for any other type of malignancy. Many people present with advanced stage cancer at diagnosis and survival is limited. Low radiation dose CT (LDCT) screening appears to offer part of the solution to this. The US National Lung Screening Trial (NLST) showed a 20% reduction in cancer related mortality and a 6.7% reduction in all cause mortality in patients who had LDCT compared to chest X-ray. Lung Cancer screening is now being implemented in the US using the NLST screening criteria but many questions remain about the details of the methodology of screening and its cost effectiveness. Many of these questions are being answered by ongoing European trials that are reporting their findings. In this review we objectively analyse current research evidence and explore the issues that need to be resolved before implementation, including technical considerations, selection criteria and effective nodule management protocols. We discuss the potential barriers that will be faced when beginning a national screening programme and possible solutions to them.
authors.affiliation: Respiratory Medicine Unit, David Evans Centre, University of Nottingham, Nottingham City Hospital Campus,Nottingham, UK - David.baldwin@nuh.nhs.uk.
authors.forename: G S
authors.initials: GS
authors.lastname: Jones
authors.forename: D R
authors.initials: DR
authors.lastname: Baldwin
mesh_terms: D003362:Cost-Benefit Analysis; D055088:Early Detection of Cancer / Q000379:methods*; D019317:Evidence-Based Medicine; D014943:Global Health; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000191:economics / Q000401:mortality / Q000628:therapy; D008400:Mass Chest X-Ray / Q000379:methods; D008403:Mass Screening / Q000379:methods*; D009367:Neoplasm Staging; D018579:Patient Selection; D049268:Positron-Emission Tomography; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed