title: Treatment of Chronic Hepatitis C in Special Populations.
abstract: The management of hepatitis C virus (HCV) infection in special populations is challenging. The efficacy and safety data of the currently approved all-oral direct-acting antiviral combinations, including sofosbuvir, ledipasvir, daclatasvir, paritaprevir/ritonavir/ombitasvir plus dasabuvir (3D), and ribavirin, is compelling for use in special HCV populations, as has recently been recommended by expert guidelines. The treatment regimens and sustained virological response rates for special populations are nearly similar to those of the general HCV population. Sofosbuvir is not recommended in patients with severe renal impairment, and simeprevir and 3D regimen are not recommended for those with decompensated liver disease.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Rajavithi Road, Ratchathewi, Bangkok 10400, Thailand. Electronic address: dr.chalermrat@gmail.com.
authors.forename: Chalermrat
authors.initials: C
authors.lastname: Bunchorntavakul
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok 10700, Thailand.
authors.forename: Tawesak
authors.initials: T
authors.lastname: Tanwandee
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D060085:Coinfection / Q000188:drug therapy; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000821:virology; D008103:Liver Cirrhosis / Q000150:complications* / Q000821:virology; D016031:Liver Transplantation
chemical_list: D000998:Antiviral Agents
keywords: Chronic kidney disease; Decompensated cirrhosis; HIV coinfection; Hepatitis C virus; Liver transplantation; Treatment