title: Laparoscopic Gastric Mobilization Reduces Postoperative Mortality After Esophageal Cancer Surgery: A French Nationwide Study.
abstract: OBJECTIVE
  This study was designed to investigate the impact of laparoscopic gastric mobilization (LGM) on 30-day postoperative mortality (POM) after surgery for esophageal cancer (EC).
  
  
  BACKGROUND
  Meta-analyses of nonrandomized studies have failed to demonstrate any significant benefit of hybrid minimally invasive esophagectomy on POM, potentially due to small population samples. Moreover, none of the published randomized trials have been designed to answer this question.
  
  
  METHODS
  All consecutive patients who underwent EC resection between 2010 and 2012 in France were included in this nationwide study (n = 3009). Data were extracted from the French National Health Service Database with internal and external quality controls. Patients treated with LGM (LGM group, n = 663) were compared with those treated with open approach (open group, n = 2346). Propensity score matching and multivariable analyses were used to compensate for the differences in baseline characteristics.
  
  
  RESULTS
  The 30-day POM rate was 5.2%, significantly lower after LGM, compared with open surgery (3.3% vs 5.7%, P = 0.005), as well as in-hospital (5.6% vs 8.1%, P = 0.028), and 90-day POM (6.9% vs 10.0%, P = 0.016). After propensity score matching, 30-day POM rates were 3.3% versus 5.9%, respectively (P = 0.029). By multivariable analysis, age ≥60 years, malnutrition and cardiovascular comorbidity were independently associated with higher POM, whereas LGM was associated with a decrease in POM (OR 0.60, 95% CI 0.37-0.98, P = 0.041).
  
  
  CONCLUSIONS
  This all-inclusive nationwide study strongly suggests that POM is significantly reduced after LGM for EC. This is high valuable evidence that helps decision making regarding the optimal approach for EC surgery.
authors.affiliation: *Department of Digestive and Oncological Surgery, University Hospital Claude Huriez, Regional University Hospital Center, Lille, France †North of France University, Lille, France ‡Jean-Pierre Aubert Research Centre, Lille, France §SIRIC OncoLille, Lille, France ||Department of biostatistics, University Hospital, Lille, France ¶Hox-Com Analytiques, Paris, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Messager
authors.forename: Arnaud
authors.initials: A
authors.lastname: Pasquer
authors.forename: Alain
authors.initials: A
authors.lastname: Duhamel
authors.forename: Gilbert
authors.initials: G
authors.lastname: Caranhac
authors.forename: Guillaume
authors.initials: G
authors.lastname: Piessen
authors.forename: Christophe
authors.initials: C
authors.lastname: Mariette
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000401:mortality / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D057216:Propensity Score; D012189:Retrospective Studies; D013270:Stomach / Q000601:surgery*; D015996:Survival Rate / Q000639:trends