title: Outcome of Nonpersonalized Human Papillomavirus Vaccinations During Postconization Follow-up: A Report of Two Cases.
abstract: BACKGROUND
  The human papillomavirus (HPV) vaccine was conceived to prevent new HPV infections among uninfected young women. From the initial intentions, its use has been extended to older women and also tested as a therapeutic tool. We report two HPV vaccination outcomes during postconization follow-up.
  
  
  METHODS
  Two young women, with different clinical histories, were subjected to HPV vaccine after a loop electrosurgical excision procedure for high-grade cervical intraepithelial neoplasia (CIN) and persisting low-grade CIN. During follow-up both women experienced a worsening of cervical lesions, which resulted in invasive cervical cancer and severe dysplasia, respectively.
  
  
  CONCLUSIONS
  Limited to our experience, a nonpersonalized HPV vaccine administration during postconization follow-up was expensive and unnecessary.
authors.forename: Luca
authors.initials: L
authors.lastname: Giannella
authors.forename: Kabala
authors.initials: K
authors.lastname: Mfuta
authors.forename: Cristina
authors.initials: C
authors.lastname: Fodero
authors.forename: Sonia
authors.initials: S
authors.lastname: Prandi
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D003127:Colposcopy; D019092:Conization; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D030361:Papillomavirus Infections / Q000517:prevention & control* / Q000601:surgery; D053918:Papillomavirus Vaccines / Q000627:therapeutic use*; D055502:Secondary Prevention; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000517:prevention & control* / Q000601:surgery; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control* / Q000601:surgery; D002578:Uterine Cervical Dysplasia / Q000517:prevention & control* / Q000601:surgery
chemical_list: D053918:Papillomavirus Vaccines