title: Silver- and fluoride-containing mesoporous bioactive glasses versus commonly used antibiotics: Activity against multidrug-resistant bacterial strains isolated from patients with burns.
abstract: The wound healing process is frequently associated with a number of major clinical challenges, due to the failure of commonly used antibiotics as a remedy for wounds. There have always been fascinating questions about the novel applications of bioactive glasses (BGs) and it is expected that in the next few years these types of materials may play an important role in many aspects of soft tissue regeneration. This research focuses on the feasibility of using silver- and fluoride-containing BGs against multidrug-resistant bacterial strains isolated from patients with burns. According to the results obtained, fluoride did not exhibit antibacterial activity against the tested bacteria, while both 1% and 2% silver-containing BGs inhibited the bacterial growth. It is an important finding that 1% silver-containing BGs showed a potential antibacterial activity without any toxicity against fibroblasts, suggesting that this class of BGs could play a key role in the prevention of infection, reduction of pain, and removal of excessive exudates.
authors.affiliation: Biotechnology Department, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: mazaher.gholipour@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Gholipourmalekabadi
authors.affiliation: Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Sameni
authors.affiliation: Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Hashemi
authors.affiliation: Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Zamani
authors.affiliation: Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Rostami
authors.affiliation: Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran. Electronic address: mozafari.masoud@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Mozafari
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology; D002056:Burns / Q000382:microbiology*; D002228:Carbenicillin / Q000494:pharmacology; D000077723:Cefepime; D002442:Ceftazidime / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002511:Cephalosporins / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D005459:Fluorides / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology; D005898:Glass; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D000077731:Meropenem; D051379:Mice; D008826:Microbial Sensitivity Tests; D041681:NIH 3T3 Cells; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D000077725:Piperacillin, Tazobactam Drug Combination; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012834:Silver / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology; D014031:Tobramycin / Q000494:pharmacology; D014946:Wound Infection / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D013845:Thienamycins; D000077725:Piperacillin, Tazobactam Drug Combination; D012834:Silver; D002939:Ciprofloxacin; D015378:Imipenem; D002443:Ceftriaxone; D000077723:Cefepime; D000583:Amikacin; D010397:Penicillanic Acid; D002442:Ceftazidime; D000077731:Meropenem; D001398:Aztreonam; D002228:Carbenicillin; D005459:Fluorides; D014031:Tobramycin; D010878:Piperacillin
keywords: Antibacterial activity; Bioactive glass; Fluoride; Silver; Wound healing