title: Triterpenes from the exudate of Gardenia urvillei.
abstract: A cycloartane gardurvilleic acid, three 3,4-seco-cycloartanes securvienol, secodienurvilleic acid, securvitriol, a 3,4;9,10-seco-cycloartane gardheptlactone, two dammaranes urvilone, urvilol, along with eight known cycloartanes and 3,4-seco-cycloartanes and four known dammaranes have been isolated from the bud exudate of Gardenia urvillei, an endemic tree to the New Caledonian dry forest. Two other dammarane derivatives have been obtained by semisynthesis. The structures of the original compounds were determined by spectroscopic methods and chemical correlations. In association with previously published data, the description of oxidized side-chains in position 17 are now available for two couples of diastereoisomers. Evaluation of anti-parasite activity and cytotoxicity has shown noticeable results for some of the isolated triterpenes.
authors.affiliation: Laboratoire de Pharmacognosie, Université de Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, UMR-CNRS 8638 COMETE, 4 avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Hoang Linh
authors.initials: HL
authors.lastname: Mai
authors.affiliation: Unité Molécules de Communication et Adaptation des Microorganismes (MCAM, UMR 7245), Muséum National d'Histoire Naturelle, CNRS, Sorbonne Universités, CP52, 57 rue Cuvier, 75005 Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Grellier
authors.affiliation: Laboratoire de Pharmacognosie, Université de Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, UMR-CNRS 8638 COMETE, 4 avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Prost
authors.affiliation: Laboratoire de Cristallographie et RMN biologiques, Université de Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, UMR-CNRS 8015, 4 avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Lemoine
authors.affiliation: Laboratoire des Plantes Médicinales, UPR2301, CNRS, BP643, 98845 Nouméa Cedex, New Caledonia.
authors.forename: Cyril
authors.initials: C
authors.lastname: Poullain
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, UPR2301, CNRS, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.affiliation: Laboratoire de Pharmacognosie, Université de Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, UMR-CNRS 8638 COMETE, 4 avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Deguin
authors.affiliation: Laboratory of Analytic Control, Faculty of Pharmacy, University of Medical science of Ho Chi Minh City, 41 Dinh Tien Hoang st. 1st district, Ho Chi Minh City, Viet Nam.
authors.forename: Thi Bach Hue
authors.initials: TBH
authors.lastname: Vo
authors.affiliation: Laboratoire de Pharmacognosie, Université de Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, UMR-CNRS 8638 COMETE, 4 avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michel
authors.affiliation: Laboratoire de Pharmacognosie, Université de Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, UMR-CNRS 8638 COMETE, 4 avenue de l'Observatoire, 75006 Paris, France. Electronic address: raphael.grougnet@parisdescartes.fr.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Grougnet
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D032062:Gardenia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D053147:Plant Exudates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000097669:Dammaranes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053147:Plant Exudates; D014315:Triterpenes; D000097669:Dammaranes; C085352:cycloartane
keywords: Cycloartane; Cytotoxicity; Dammarane; Gardenia urvillei; Plasmodium; Rubiaceae; Seco-cycloartane; Trypanosoma