title: Prenylated 2-arylbenzofuran derivatives with potent antioxidant properties from Chlorophora regia (Moraceae).
abstract: Extracts of Chlorophora regia are frequently used in Ghana in traditional medicine. There is, however, no reported data on the chemical composition of the plant. Comprehensive phytochemical investigation of the stem bark of C. regia resulted in the isolation of three new prenylated 2-arylbenzofuran derivatives, regiafuran A-C (1-3), and one new prenylated flavonol (4), together with fifteen known compounds (5-19). Their structures were elucidated by combined spectroscopic analysis of their NMR and HRESI-MS(n) data. Compounds 1, 2, 5, 9 and 15 exhibited remarkable free radical scavenging properties with IC50 values of 1.9 μg/ml, 2.4 μg/ml, 2.2 μg/ml, 2.1 μg/ml and 1.8 μg/ml, respectively, compared to the standard trolox (IC50 1.1 μg/ml). The isolated compounds did not, however, show any anti-inflammatory potential when tested using a PGE2 (prostaglandin E2) competitive enzyme immunoassay.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany.
authors.forename: James Oppong
authors.initials: JO
authors.lastname: Kyekyeku
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany.
authors.forename: Souvik
authors.initials: S
authors.lastname: Kusari
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Reimmel Kwame
authors.initials: RK
authors.lastname: Adosraku
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Zühlke
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany. Electronic address: m.spiteller@infu.tu-dortmund.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Spiteller
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D005869:Ghana; D016488:Medicine, African Traditional; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D054876:Prenylation
chemical_list: D001572:Benzofurans; D016166:Free Radical Scavengers; D010936:Plant Extracts
keywords: 2-arylbenzofuran derivatives; Antioxidant; Chlorophora regia; Flavonols; Moraceae