title: Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study.
abstract: BACKGROUND
  Positron emission tomography (PET) images with amyloid tracers show normal uptake in healthy white matter, which suggests that amyloid tracers are potentially useful for studying such white matter diseases as multiple sclerosis (MS).
  
  
  METHODS
  Twelve patients diagnosed with MS (5 with RRMS, 5 with SPMS, and 2 with PPMS) and 3 healthy controls underwent studies with MRI and (18)F-florbetaben-PET imaging. Images were preprocessed using Statistical Parametric Mapping software. We analysed (18)F-florbetaben uptake in demyelinating plaques (appearing as hyperintense lesions in FLAIR sequences), in normal-appearing white matter, and in grey matter.
  
  
  RESULTS
  Mean standardized uptake value relative to cerebellum was higher in normally appearing white matter (NAWM) (1.51 ± 0.12) than in damaged white matter (DWM) (1.24 ± 0.12; P = .002). Mean percentage of change between NAWM and DWM was -17.56% ± 6.22%. This percentage of change correlated negatively with EDSS scores (r = -0.61, p < .05) and with age (r = -0.83, p < 0.01). Progressive forms of MS showed a more pronounced reduction of the uptake in DWM in comparison to relapsing-remitting form.
  
  
  CONCLUSIONS
  Uptake of (18)F-florbetaben in damaged white matter is lower than that occurring in normally-appearing white matter. These findings indicate that amyloid tracers may be useful in studies of MS, although further research is needed to evaluate the utility of amyloid-PET in monitoring MS progression.
authors.affiliation: Department of Neurology, Hospital Clínico San Carlos. San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Calle Profesor Martín Lagos, S/N, Madrid, 28040, Spain. jordimatiasguiu@hotmail.com.
authors.forename: Jordi A
authors.initials: JA
authors.lastname: Matías-Guiu
authors.affiliation: Department of Nuclear Medicine, Hospital Clínico San Carlos. San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Calle Profesor Martín Lagos, S/N, Madrid, 28040, Spain. mncabreram@hotmail.com.
authors.forename: María Nieves
authors.initials: MN
authors.lastname: Cabrera-Martín
authors.affiliation: Department of Neurology, Hospital Clínico San Carlos. San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Calle Profesor Martín Lagos, S/N, Madrid, 28040, Spain. matiasguiu@gmail.com.
authors.forename: Jorge
authors.initials: J
authors.lastname: Matías-Guiu
authors.affiliation: Department of Neurology, Hospital Clínico San Carlos. San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Calle Profesor Martín Lagos, S/N, Madrid, 28040, Spain. orejacbn@gmail.com.
authors.forename: Celia
authors.initials: C
authors.lastname: Oreja-Guevara
authors.affiliation: Department of Nuclear Medicine, Hospital Clínico San Carlos. San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Calle Profesor Martín Lagos, S/N, Madrid, 28040, Spain. cristinariola@yahoo.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: Riola-Parada
authors.affiliation: Department of Neurology, Hospital Clínico San Carlos. San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Calle Profesor Martín Lagos, S/N, Madrid, 28040, Spain. tmorenoramos@yahoo.es.
authors.forename: Teresa
authors.initials: T
authors.lastname: Moreno-Ramos
authors.affiliation: Department of Radiology, Hospital Clínico San Carlos. San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Calle Profesor Martín Lagos, S/N, Madrid, 28040, Spain. juan.arrazola@salud.madrid.org.
authors.forename: Juan
authors.initials: J
authors.lastname: Arrazola
authors.affiliation: Department of Nuclear Medicine, Hospital Clínico San Carlos. San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Calle Profesor Martín Lagos, S/N, Madrid, 28040, Spain. joseluis.carreras@salud.madrid.org.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Carreras
mesh_terms: D000328:Adult; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds; D005260:Female; D005462:Fluorine Radioisotopes; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D013267:Stilbenes; D066127:White Matter / Q000000981:diagnostic imaging / Q000378:metabolism
chemical_list: D000682:Amyloid; D000814:Aniline Compounds; D005462:Fluorine Radioisotopes; D013267:Stilbenes; C527756:4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene