title: Phyllodes tumor of the breast: a clinic-pathologic study of 77 cases in a Hispanic cohort.
abstract: BACKGROUND
  Breast Phyllodes tumors are rare breast tumors present in less than 1% of new cases of breast cancer, usually occurring among middle-aged women (40-50 yrs).
  
  
  OBJECTIVE
  This study shows diagnostic experience, surgical management and follows up of patients with this disease during a period of ten years in a oncology referral center.
  
  
  METHODS
  Retrospectively, breast cancer registries at the institution were reviewed, identifying 77 patients with Phyllodes tumors between 2002 and 2012, who had been operated on at the Instituto de Cancerología - Clínica Las Américas, in Medellín (Colombia). Clinical and histopathological data belonging to these cases was captured and analyzed and descriptive statistics were used.
  
  
  RESULTS
  The follow up median was 22.5 months (IQR: 10.5-60.0), average age was 47.2 yrs (SD: 12.4), mean tumor size was 3.6 cm (SD: 4.6), 88.3% of the patients (68 cases) presented negative margins and none of them received adjuvant chemotherapy. Of the patients with Phyllodes tumors; 33.8% had benign, 31.2% had borderline and 35.0% had malignant tumor. Disease-free survival was 85.8% and overall survival was 94.5%.
  
  
  CONCLUSIONS
  Reported data in this article is in accordance with what has been reported in worldwide literature. In our cohort even the high mean size of the tumors, the risk of local relapse and metastatic disease is low than previously reported in literature. Trials with longer follow up and molecular trials in Phyllodes tumors are necessary to understand the behavior of these tumors in Hispanics population.
authors.affiliation: Grupo de Investigacion en Cancer IDC. Instituto de Cancerología, Medellin, Colombia.
authors.forename: Carlos Andres
authors.initials: CA
authors.lastname: Ossa
authors.affiliation: Grupo de Investigacion en Cancer IDC. Instituto de Cancerología, Medellin, Colombia.
authors.forename: Fernando
authors.initials: F
authors.lastname: Herazo
authors.affiliation: Grupo de Investigacion en Cancer IDC. Instituto de Cancerología, Medellin, Colombia.
authors.forename: Monica
authors.initials: M
authors.lastname: Gil
authors.affiliation: Grupo de Investigacion en Cancer IDC. Instituto de Cancerología, Medellin, Colombia.
authors.forename: Carolina
authors.initials: C
authors.lastname: Echeverri
authors.affiliation: Grupo de Investigacion en Cancer IDC. Instituto de Cancerología, Medellin, Colombia.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Ángel
authors.affiliation: Grupo de Investigacion en Cancer IDC. Instituto de Cancerología, Medellin, Colombia.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Borrero
authors.affiliation: Grupo de Investigacion en Cancer IDC. Instituto de Cancerología, Medellin, Colombia.
authors.forename: Jorge
authors.initials: J
authors.lastname: Madrid
authors.affiliation: Grupo de Investigacion en Cancer IDC. Instituto de Cancerología, Medellin, Colombia.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Jaramillo
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003105:Colombia; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Breast; Phyllodes tumor; fibroadenoma; fibroepithelial tumor; pathology