title: Immunomodulation and Disease Tolerance to Staphylococcus aureus.
abstract: The Gram-positive bacterium Staphylococcus aureus is one of the most frequent pathogens that causes severe morbidity and mortality throughout the world. S. aureus can infect skin and soft tissues or become invasive leading to diseases such as pneumonia, endocarditis, sepsis or toxic shock syndrome. In contrast, S. aureus is also a common commensal microbe and is often part of the human nasal microbiome without causing any apparent disease. In this review, we explore the immunomodulation and disease tolerance mechanisms that promote commensalism to S. aureus.
authors.affiliation: Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montréal, QC, H3A 2B4, Canada. zhigang.li@mail.mcgill.ca.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montréal, QC, H3A 2B4, Canada. adam.peres@mail.mcgill.ca.
authors.forename: Adam G
authors.initials: AG
authors.lastname: Peres
authors.affiliation: Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montréal, QC, H3A 2B4, Canada. andreea.damian@mail.mcgill.ca.
authors.forename: Andreea C
authors.initials: AC
authors.lastname: Damian
authors.affiliation: Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montréal, QC, H3A 2B4, Canada. joaquin.madrenas@mcgill.ca.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Madrenas
keywords: Staphylococcus aureus; disease tolerance; immunomodulation; interleukin-10; microbiome