title: Use of computational and recombinant technologies for developing novel influenza vaccines.
abstract: Influenza vaccine design has changed considerably with advancements in bioinformatics and computational biology. Improved surveillance efforts provide up-to-date information about influenza sequence diversity and assist with monitoring the spread of epidemics and vaccine efficacy rates. The advent of next-generation sequencing, epitope scanning and high-throughput analysis all help decipher influenza-associated protein interactions as well as predict immune responsiveness based on host genetic diversity. Computational approaches are utilized in nearly all aspects of vaccine design, from modeling, compatibility predictions, and optimization of antigens in various platforms. This overview discusses how computational techniques strengthen vaccine efforts against highly diverse influenza species.
authors.affiliation: a Center for Vaccines and Immunology, Department of Infectious Diseases , University of Georgia , Athens , GA , USA.
authors.forename: Terianne M
authors.initials: TM
authors.lastname: Wong
authors.affiliation: a Center for Vaccines and Immunology, Department of Infectious Diseases , University of Georgia , Athens , GA , USA.
authors.forename: Ted M
authors.initials: TM
authors.lastname: Ross
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D007252:Influenza Vaccines / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D009976:Orthomyxoviridae Infections / Q000517:prevention & control* / Q000662:veterinary; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification
chemical_list: D007252:Influenza Vaccines; D014614:Vaccines, Synthetic
keywords: bioinformatics; computational approaches; influenza; vaccine