title: Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo.
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg.
authors.forename: Caroline
authors.initials: C
authors.lastname: Ebert
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg.
authors.forename: Florian
authors.initials: F
authors.lastname: Perner
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg.
authors.forename: Denise
authors.initials: D
authors.lastname: Wolleschak
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg Collaborative Research Cluster 854, Medical Faculty, Otto-von-Guericke University Medical Center, Magdeburg.
authors.forename: Tina M
authors.initials: TM
authors.lastname: Schnöder
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg Collaborative Research Cluster 854, Medical Faculty, Otto-von-Guericke University Medical Center, Magdeburg.
authors.forename: Thomas
authors.initials: T
authors.lastname: Fischer
authors.affiliation: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg Collaborative Research Cluster 854, Medical Faculty, Otto-von-Guericke University Medical Center, Magdeburg Internal Medicine II, Department of Hematology and Oncology, Friedrich-Schiller-University Jena Current Address: Leibniz-Institute on Aging, Fritz-Lipmann-Institute, Jena, Germany florian.h.heidel@gmail.com.
authors.forename: Florian H
authors.initials: FH
authors.lastname: Heidel
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics / Q000276:immunology; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2 / Q000235:genetics* / Q000276:immunology; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics / Q000276:immunology; D000970:Antineoplastic Agents / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D037181:Lectins, C-Type / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics* / Q000276:immunology; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics* / Q000276:immunology; D009570:Nitriles; D010835:Phytohemagglutinins / Q000494:pharmacology; D011087:Polycythemia Vera / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D061251:Primary Cell Culture; D055728:Primary Myelofibrosis / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology*; D011743:Pyrimidines; D015398:Signal Transduction; D016896:Treatment Outcome; D000099192:CD69 Antigens
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000970:Antineoplastic Agents; D053614:Janus Kinase 2; D037181:Lectins, C-Type; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009363:Neoplasm Proteins; D009570:Nitriles; D010835:Phytohemagglutinins; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; D000099192:CD69 Antigens; C513055:ABCB1 protein, human; C116614:ABCG2 protein, human; C101135:phytohemagglutinin L protein, Phaseolus vulgaris; C540383:ruxolitinib; C507926:Jak2 protein, mouse; C421109:multidrug resistance-associated protein 1
keywords: ABCB1; ABCG2; JAK2; T-cell; ruxolitinib