title: Comparison of preoperative nepafenac (0.1%) and flurbiprofen (0.03%) eye drops in maintaining mydriasis during small incision cataract surgery in patients with senile cataract: A randomized, double-blind study.
abstract: OBJECTIVE
  This study compared the effectiveness of prophylactic administration of topical flurbiprofen 0.03% and nepafenac 0.1% in maintaining mydriasis during small incision cataract surgery (SICS).
  
  
  METHODS
  This study was a prospective, randomized, double-blind comparative study in adult cataract patients given topical flurbiprofen or nepafenac prior to SICS and capsular bag intraocular lens (IOL) implantation at a tertiary care hospital. Horizontal and vertical diameters of pupil were measured at the beginning and end of surgery, and the mean values were compared across the two groups. Unpaired t-test and Fisher's exact test were used to analyse the results.
  
  
  RESULTS
  A total of 70 eyes of cataract surgery patients, 33 males and 37 females, with a mean age of 58.5 ± 11.24 years, were included in the study. The mean horizontal and vertical diameters of the two groups were similar at the start of surgery. Significant differences were seen after IOL implantation, with the nepafenac group having the larger mean diameters in both horizontal (P = 0.03) and vertical (P = 0.04) pupillary measurements.
  
  
  CONCLUSIONS
  Topical nepafenac has been shown to be a more effective inhibitor of meiosis during SICS and provides a more stable mydriatic effect compared to topical flurbiprofen.
authors.affiliation: Department of Pharmacology, R.G. Kar M.C. and H, Kolkata, West Bengal, India.
authors.forename: Saumya
authors.initials: S
authors.lastname: Sarkar
authors.affiliation: Department of Ophthalmology, R.G. Kar M.C. and H, Kolkata, West Bengal, India.
authors.forename: Kanchan Kumar
authors.initials: KK
authors.lastname: Mondal
authors.affiliation: Department of Pharmacology, R.G. Kar M.C. and H, Kolkata, West Bengal, India.
authors.forename: Sukalyan Saha
authors.initials: SS
authors.lastname: Roy
authors.affiliation: Department of Ophthalmology, R.G. Kar M.C. and H, Kolkata, West Bengal, India.
authors.forename: Sharmistha
authors.initials: S
authors.lastname: Gayen
authors.affiliation: Department of Pharmacology, College of Medicine and J.N.M. Hospital, Kalyani, West Bengal, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Department of Pharmacology, R.G. Kar M.C. and H, Kolkata, West Bengal, India.
authors.forename: Radha Raman
authors.initials: RR
authors.lastname: De
mesh_terms: D060433:Administration, Ophthalmic; D000368:Aged; D044482:Benzeneacetamides / Q000008:administration & dosage*; D002387:Cataract Extraction / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D010648:Phenylacetates / Q000008:administration & dosage*; D011300:Preoperative Care / Q000379:methods; D011446:Prospective Studies
chemical_list: D044482:Benzeneacetamides; D009184:Mydriatics; D009883:Ophthalmic Solutions; D010648:Phenylacetates; C414203:nepafenac; D005480:Flurbiprofen
keywords: Eye drops; flurbiprofen; mydriasis; nepafenac; senile cataract