title: [Genetically determined lipid metabolism disorders due to oral intake of technogenic hyperchlorination products].
abstract: The study covered genetically determined lipid metabolism disorders due to oral intake of technogenic hyperchlorination drinkable water products. Findings are that overweight and obese children in a main group appeared to have serum chloroform level 2.3 times higher than that in a reference group. In oral intake of hyperchlorination drinkable water products, the study revealed main genes having polymorphism associated with endocrine disorders: overweight and obesity--APOE, PPARG, HTR2A, characterizing antioxidant system state--SOD2 and detoxication--SULTA. Polymorphism of candidate genes HTR2A and SOD2 was characterized by increased occurrence of mutant homo-- and heterozygous genotype, relative risk of pathologic allele presence in population exceeded the refrence group values. Probability of increased serum serotonin and lower Cu/Zn in children with mutant homozygous genotype HTR2A and SOD2 is 1.2-1.3 times higher than in those with heterozygous and normal homozygous genotypes.
authors.forename: K P
authors.initials: KP
authors.lastname: Luzhetsky
authors.forename: O V
authors.initials: OV
authors.lastname: Dolgikh
authors.forename: O Yu
authors.initials: OY
authors.lastname: Ustinova
authors.forename: A M
authors.initials: AM
authors.lastname: Krivtsov
mesh_terms: D002648:Child; D002725:Chloroform / Q000097:blood / Q000633:toxicity*; D060766:Drinking Water / Q000737:chemistry; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D063766:Pediatric Obesity / Q000139:chemically induced* / Q000235:genetics; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics*; D014874:Water Pollutants, Chemical / Q000097:blood / Q000633:toxicity*; D000099156:Superoxide Dismutase 2
chemical_list: D002725:Chloroform; D060766:Drinking Water; D044402:Receptor, Serotonin, 5-HT2A; D013482:Superoxide Dismutase; D014874:Water Pollutants, Chemical; D000099156:Superoxide Dismutase 2