title: An Apoferritin-based Drug Delivery System for the Tyrosine Kinase Inhibitor Gefitinib.
abstract: Anticancer drug Gefitinib encapsulated within human heavy chain apoferritin by diffusion allows pH-controlled sustained release of cargo. The combination of increased cellular uptake, and potent and enhanced antitumor activity against the HER2 overexpressing SKBR3 cell line compared to Gefitinib alone, makes it a promising carrier for delivery of drugs to tumor sites.
authors.affiliation: Centre for Biomolecular Sciences, School of Pharmacy, The University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: Anchala I
authors.initials: AI
authors.lastname: Kuruppu
authors.affiliation: Centre for Biomolecular Sciences, School of Chemistry, The University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Centre for Biomolecular Sciences, School of Pharmacy, The University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: Hilary
authors.initials: H
authors.lastname: Collins
authors.affiliation: School of Physics and Astronomy, The University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Turyanska
authors.affiliation: Centre for Biomolecular Sciences, School of Chemistry, The University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: Neil R
authors.initials: NR
authors.lastname: Thomas
authors.affiliation: Centre for Biomolecular Sciences, School of Pharmacy, The University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: Tracey D
authors.initials: TD
authors.lastname: Bradshaw
mesh_terms: D001052:Apoferritins / Q000378:metabolism*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods*; D004705:Endocytosis / Q000187:drug effects; D000077156:Gefitinib; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*
chemical_list: D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D001052:Apoferritins; D000077156:Gefitinib
keywords: Gefitinib; apoferritin; breast cancer; drug delivery; nanoparticles