title: The Etiologic Role of Infectious Antigens in Sarcoidosis Pathogenesis.
abstract: Sarcoidosis is a granulomatous disease of unknown etiology, most commonly involving the lung, skin, lymph node, and eyes. Molecular and immunologic studies continue to strengthen the association of sarcoidosis with infectious antigens. Independent studies report the presence of microbial nucleic acids and proteins within sarcoidosis specimens. Complementary immunologic studies also support the role of infectious agents in sarcoidosis pathogenesis. Case reports and clinical trials have emerged regarding the efficacy of antimicrobials. They support increasing efforts to identify novel therapeutics, such as antimicrobials, that will have an impact on the observed increase in sarcoidosis morbidity and mortality.
authors.affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Avenue South, A2200 Medical Center North, Nashville, TN 37232, USA.
authors.forename: Lindsay J
authors.initials: LJ
authors.lastname: Celada
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical School, 1161 21st Avenue South, A2200 Medical Center North, Nashville, TN 37232, USA.
authors.forename: Charlene
authors.initials: C
authors.lastname: Hawkins
authors.affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Avenue South, A2200 Medical Center North, Nashville, TN 37232, USA; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical School, 1161 21st Avenue South, A2200 Medical Center North, Nashville, TN 37232, USA. Electronic address: Wonder.Drake@vanderbilt.edu.
authors.forename: Wonder P
authors.initials: WP
authors.lastname: Drake
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D006099:Granuloma / Q000150:complications*; D006801:Humans; D008168:Lung / Q000473:pathology; D012507:Sarcoidosis / Q000209:etiology* / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents
keywords: Antimicrobials; Infectious antigens; Sarcoidosis