title: Low Virologic Failure and Drug Resistance among HIV-Infected Patients Receiving Hospital-Based ART While Care and Outreach through Community in Guangxi, China.
abstract: OBJECTIVE
  To investigate human immunodeficiency virus (HIV) virologic suppression and drug resistance among HIV-infected patients receiving first-line antiretroviral treatment (ART) in hospitals while community care and outreach through local health workers in Guangxi, China.
  
  
  METHODS
  This was a series of cross-sectional surveys from 2004 to 2012 in Guangxi, supported by the Chinese National HIVDR Surveillance and Monitoring Network Working Group.
  
  
  METHODS
  Guangxi, China.
  
  
  METHODS
  Demographic, ART, and laboratory data (CD4(+) cell count, viral load, and drug resistance) were analyzed. Factors associated with virologic suppression were identified by logistic regression analysis.
  
  
  RESULTS
  A total of 780 patients were included in this study. The median treatment duration was 20.6 months (IQR 6.6-35.9). Of 780 study participants, 95.4% of patients (744/780) had HIV virologic suppression. Among these, of the 143 patients who were infected through drug injection, only 10 (7.0%) experienced virologic failure, and the overall prevalence of HIV drug resistance was 2.8% (22/789). Factors associated with virologic suppression in the final multivariate models included self-reported missing doses in the past month (compared to not missing doses in the past month, AOR = 0.2, 95% CI: 0.1-0.6) and initial ART regimen without 3TC (compared to initial ART regimen with 3TC, AOR = 0.2, 95% CI: 0.1-0.4). Moreover, the trend chi-square test showed that the proportion of virologic suppression increased over time from 2004 to 2012 (P = 0.002).
  
  
  CONCLUSIONS
  This study first demonstrated that HIV patients infected through various transmission routes can achieve an excellent treatment outcome in hospitals at or above the county level for free first-line ART in Guangxi. It is an important of ART education and adherence to intervention for achieving better treatment outcomes.
authors.affiliation: Guangxi Center for Disease Control and Prevention , Nanning , China.
authors.forename: Shujia
authors.initials: S
authors.lastname: Liang
authors.affiliation: Guangxi Center for Disease Control and Prevention , Nanning , China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.affiliation: Guangxi Center for Disease Control and Prevention , Nanning , China.
authors.forename: Fuxiong
authors.initials: F
authors.lastname: Liang
authors.affiliation: Guangxi Center for Disease Control and Prevention , Nanning , China.
authors.forename: Zhenzhu
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Guangxi Center for Disease Control and Prevention , Nanning , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Kan
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing , China.
authors.forename: Lingjie
authors.initials: L
authors.lastname: Liao
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing , China.
authors.forename: Xuebing
authors.initials: X
authors.lastname: Leng
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing , China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Ruan
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.affiliation: State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention , Beijing , China ; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing , China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
keywords: China; HIV; antiretroviral treatment; drug resistance; virologic suppression