title: [The role of long non-coding RNAs in hematologic malignancies].
abstract: With the rapid development of molecular biology technology, researchers have got much deeper understanding of the role of long non-coding RNA (lncRNA). It is not only indispensable for biological processes, but also plays an important role in human diseases especially in tumor. Previous studies have shown that a variety of lncRNAs are closely associated with hematologic malignancies. These lncRNAs are involved in diseases through diverse functions including affecting the expression of tumor suppressor gene p15, regulating p53 protein function, and interacting with miRNAs. In this review, we summarize the hematological tumor-associated lncRNAs and focus on p15, p53 and miRNA-related lncRNAs as well as the role of their interaction in hematological malignancies, which may provide a comprehensive understanding of the role of hematological tumor-associated lncRNAs and some insights for research, diagnosis and treatment of hematologic malignancies.
authors.affiliation: School of Basic Medical Sciences, Long Duration Clinical Expertise 2012 Grade 3 Class, Capital Medical University, Beijing 100069, China.
authors.forename: Wan-li
authors.initials: WL
authors.lastname: Hu
authors.affiliation: School of Public Health, Capital Medical University, Beijing 100069, China.
authors.forename: Ai
authors.initials: A
authors.lastname: Gao
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53 / Q000502:physiology; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology; D051059:PTEN Phosphohydrolase / Q000235:genetics; D062085:RNA, Long Noncoding / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: C109421:DLEU1 lncRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding; D025521:Tumor Suppressor Proteins; D051059:PTEN Phosphohydrolase