title: Take the Wnt out of the inflammatory sails: modulatory effects of Wnt in airway diseases.
abstract: Bronchial asthma and chronic obstructive pulmonary disease (COPD) are chronic diseases that are associated with inflammation and structural changes in the airways and lungs. Recent findings have implicated Wnt pathways in critically regulating inflammatory responses, especially in asthma. Furthermore, canonical and noncanonical Wnt pathways are involved in structural changes such as airway remodeling, goblet cell metaplasia, and airway smooth muscle (ASM) proliferation. In COPD, Wnt pathways are not only associated with structural changes in the airways but also involved in the development of emphysema. The present review summarizes the role and function of the canonical and noncanonical Wnt pathway with regard to airway inflammation and structural changes in asthma and COPD. Further identification of the role and function of different Wnt molecules and pathways could help to develop novel therapeutic options for these diseases.
authors.affiliation: Priority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, Borstel, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Reuter
authors.affiliation: III Medical Clinic, University Medical Center, Mainz, Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Beckert
authors.affiliation: Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Christian
authors.identifier: http://orcid.org/0000-0002-3546-1398
authors.initials: C
authors.lastname: Taube
mesh_terms: D000818:Animals; D003713:Dendritic Cells; D006801:Humans; D007249:Inflammation; D051379:Mice; D012140:Respiratory Tract Diseases; D013601:T-Lymphocytes; D060449:Wnt Signaling Pathway