title: Water spray-induced grooming is negatively correlated with depressive behavior in the forced swimming test in rats.
abstract: Rodents show grooming, a typical self-care behavior, under stress and non-stress conditions. Previous studies revealed that grooming under stress conditions such as the open-field test (OFT) or the elevated plus-maze test (EPM) is associated with anxiety, but the roles of grooming under non-stress conditions are not well understood. Here, we examined spray-induced grooming as a model of grooming under a non-stress condition to investigate the relationship between this grooming and depression-like behavior in the forced swim test (FST) and tail suspension test, and we compared spray-induced grooming with OFT- and EPM-induced grooming. The main finding was that the duration of spray-induced grooming, but not that of OFT/EPM-induced grooming, was negatively correlated with the duration of immobility in the FST, an index of depression-like behavior. The results suggest that spray-induced grooming is functionally different from the grooming in the OFT and EPM and is related to reduction of depressive behavior.
authors.affiliation: Department of Human Intelligence Systems, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu, 808-0196, Japan.|Department of Health and Welfare, Seinan Jo Gakuin University, Kitakyushu, 803-0835, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Shiota
authors.affiliation: Department of Human Intelligence Systems, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu, 808-0196, Japan.|Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan.
authors.forename: Kimiya
authors.initials: K
authors.lastname: Narikiyo
authors.affiliation: Department of Human Intelligence Systems, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu, 808-0196, Japan.|Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Masuda
authors.affiliation: Department of Human Intelligence Systems, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu, 808-0196, Japan. aou@brain.kyutech.ac.jp.
authors.forename: Shuji
authors.initials: S
authors.lastname: Aou
mesh_terms: D000818:Animals; D003863:Depression / Q000523:psychology*; D004195:Disease Models, Animal; D006120:Grooming / Q000502:physiology; D008297:Male; D018782:Maze Learning; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000523:psychology; D013550:Swimming / Q000502:physiology / Q000523:psychology; D014867:Water
chemical_list: D014867:Water
keywords: Anxiety; Depression; Grooming; Immobility; Self-care