title: Synthesis and biological evaluation of some dibenzofuran-piperazine derivatives.
abstract: In the present paper, a novel series of dibenzofuran-piperazine derivatives were synthesized via the treatment of N-(2-methoxy-3-dibenzofuranyl)-2-chloroacetamide with substituted piperazine derivatives. The chemical structures of the compounds were elucidated by (1)H NMR, (13)C NMR, mass spectral data; elemental analysis and HPLC analysis. Each derivative was evaluated for antiplatelet activity and anticholinesterase activity. Compound 2 m with 2-furoyl moiety exhibited high percentage inhibition as much as standard drug aspirin on arachidonic acid (AA)-induced platelet aggregation. None of the compounds presented significant inhibitor effect on collagen-induced platelet aggregation. Furthermore, the anticholinesterase activity of the compounds was determined and they did not show promising inhibitor activity compared with standard drug donepezil.
authors.affiliation: a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey .
authors.forename: Leyla
authors.initials: L
authors.lastname: Yurttaş
authors.affiliation: b Department of Pharmaceutical Chemistry , Faculty of Pharmacy, Al-Azhar University , Gaza , Palestine , and.
authors.forename: Usama
authors.initials: U
authors.lastname: Abu Mohsen
authors.affiliation: c Department of Biochemistry , Faculty of Pharmacy, Gazi University , Ankara , Turkey.
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Ozkan
authors.affiliation: c Department of Biochemistry , Faculty of Pharmacy, Gazi University , Ankara , Turkey.
authors.forename: Simla
authors.initials: S
authors.lastname: Cobanoglu
authors.affiliation: a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey .
authors.forename: Serkan
authors.initials: S
authors.lastname: Levent
authors.affiliation: a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey .
authors.forename: Zafer Asım
authors.initials: ZA
authors.lastname: Kaplancikli
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D000077489:Piperazine; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology
chemical_list: D001572:Benzofurans; D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; D000077489:Piperazine; C023614:dibenzofuran
keywords: Anticholinesterase activity; antiplatelet activity; dibenzofuran; piperazine