title: Characteristic sonographic features of cribriform papillary thyroid carcinoma for differentiation from other thyroid nodules.
abstract: OBJECTIVE
  The purpose of this paper is to clarify the sonographic features and differential diagnoses of the cribriform variant of papillary thyroid carcinoma (CV-PTC).
  
  
  METHODS
  We retrospectively reviewed 24 nodules obtained from 22 CV-PTC cases. As control groups, we chose 50 cases each of conventional papillary carcinoma (C-PTC), follicular tumor, and nodular goiter.
  
  
  RESULTS
  All of the cases were young women aged 35 years or younger. Serum thyroglobulin levels were normal or slightly elevated. The incidences of smooth or focal jagged margin, hypoechoic nodule, lateral shadow, posterior acoustic enhancement, poor marginal and internal vascularity, and no microcalcification were 100, 100, 91.7, 95.8, 100, and 95.8 %, respectively. The sensitivity and specificity of the requirement were 87.5 and 92.5 %, respectively. Sonographic findings of CV-PTC were similar to those of follicular tumor or nodular goiter rather than C-PTC.
  
  
  CONCLUSIONS
  The criteria for suspecting CV-PTC we proposed provided high sensitivity and specificity. We should be aware that the sonographic findings of CV-PTC are similar to those of follicular tumor or nodular goiter rather than C-PTC. Clinical findings including gender, age, and serum thyroglobulin level may provide us with useful information.
authors.affiliation: Department of Clinical Laboratory, Kuma Hospital, 8-2-35 Shimoyamate-dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan. fujimoto01@kuma-h.or.jp.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Fujimoto
authors.affiliation: Department of Diagnostic Pathology, Kuma Hospital, Kobe, Hyogo, Japan.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Hirokawa
authors.affiliation: Department of Clinical Laboratory, Kuma Hospital, 8-2-35 Shimoyamate-dori, Chuo-Ku, Kobe, Hyogo, 650-0011, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Ota
authors.affiliation: Department of Surgery, Kuma Hospital, Kobe, Hyogo, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yabuta
authors.affiliation: Department of Surgery, Kuma Hospital, Kobe, Hyogo, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Fukushima
authors.affiliation: Department of Surgery, Kuma Hospital, Kobe, Hyogo, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Department of Internal Medicine, Kuma Hospital, Kobe, Hyogo, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Amino
authors.affiliation: Department of Surgery, Kuma Hospital, Kobe, Hyogo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Miyauchi
mesh_terms: D000293:Adolescent; D000328:Adult; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016606:Thyroid Nodule / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D055815:Young Adult
keywords: Cribriform variant; Papillary carcinoma; Sonography; Thyroid; Ultrasound