title: Atrial fibrillation, cognitive impairment, and neuroimaging.
abstract: BACKGROUND
  The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI).
  
  
  METHODS
  Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging.
  
  
  RESULTS
  Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70; P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80; P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34; P = .08) for no atrial fibrillation and any infarction.
  
  
  CONCLUSIONS
  Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.
authors.affiliation: Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Graff-Radford
authors.affiliation: Department of Cardiology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Malini
authors.initials: M
authors.lastname: Madhavan
authors.affiliation: Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Prashanthi
authors.initials: P
authors.lastname: Vemuri
authors.affiliation: Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Rabinstein
authors.affiliation: Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Cha
authors.affiliation: Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA; Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Mielke
authors.affiliation: Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Kejal
authors.initials: K
authors.lastname: Kantarci
authors.affiliation: Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Val
authors.initials: V
authors.lastname: Lowe
authors.affiliation: Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Senjem
authors.affiliation: Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Gunter
authors.affiliation: Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.affiliation: Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.affiliation: Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA.
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.affiliation: Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA; Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN, USA. Electronic address: roberts.rosebud@mayo.edu.
authors.forename: Rosebud O
authors.initials: RO
authors.lastname: Roberts
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D049268:Positron-Emission Tomography; D066127:White Matter / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology
chemical_list: D001057:Apolipoproteins E
keywords: Alzheimer's disease; Atrial fibrillation; Cerebrovascular disease; Mild cognitive impairment; Stroke