title: [Para-Aortic Lymphadenectomy and Subsequent Chemotherapy after Resection of the Primary Lesion for Poorly Differentiated Adenocarcinoma of the Sigmoid Colon - A Case Report].
abstract: The patient was a 68-year-old male who had bloody stools. A colonoscopy revealed a sigmoid colon stricture, and a histological examination confirmed the presence of a poorly differentiated adenocarcinoma.Computed tomography revealed the involvement of a para-aortic lymph nodes, without other metastatic lesions. The patient underwent a sigmoidectomy (with regional lymph node dissection) and a para-aortic lymph node biopsy to prove the histological conformation. Subsequently, he was provided with 6 courses of modified FOLFOX6(mFOLFOX6) chemotherapy, resulting in a marked decrease in para-aortic lymph node involvement. He subsequently underwent a para-aortic lymphadenectomy. The resected specimen was mostly composed of fibrous degenerative tissue; viable cancer cells were observed only in a 2-mm² area. The patient was provided with 6 more courses of mFOLFOX6 chemotherapy, and has since been free of recurrence (for 6 years and 1 month after the second surgery).
authors.affiliation: Dept. of Surgery, Saitama Cooperative Hospital.
authors.forename: Tadao
authors.initials: T
authors.lastname: Kuribara
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Shiori
authors.initials: S
authors.lastname: Kaneko
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Osa
authors.forename: Mamoru
authors.initials: M
authors.lastname: Ueda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Kouzou
authors.initials: K
authors.lastname: Asanuma
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sano
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishizu
authors.forename: Akira
authors.initials: A
authors.lastname: Iai
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001011:Aorta / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008197:Lymph Node Excision; D008297:Male; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012008:Recurrence; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil