title: SugarBindDB, a resource of glycan-mediated host-pathogen interactions.
abstract: The SugarBind Database (SugarBindDB) covers knowledge of glycan binding of human pathogen lectins and adhesins. It is a curated database; each glycan-protein binding pair is associated with at least one published reference. The core data element of SugarBindDB is a set of three inseparable components: the pathogenic agent, a lectin/adhesin and a glycan ligand. Each entity (agent, lectin or ligand) is described by a range of properties that are summarized in an entity-dedicated page. Several search, navigation and visualisation tools are implemented to investigate the functional role of glycans in pathogen binding. The database is cross-linked to protein and glycan-relaled resources such as UniProtKB and UniCarbKB. It is tightly bound to the latter via a substructure search tool that maps each ligand to full structures where it occurs. Thus, a glycan-lectin binding pair of SugarBindDB can lead to the identification of a glycan-mediated protein-protein interaction, that is, a lectin-glycoprotein interaction, via substructure search and the knowledge of site-specific glycosylation stored in UniCarbKB. SugarBindDB is accessible at: http://sugarbind.expasy.org.
authors.affiliation: Proteome Informatics Group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland.
authors.forename: Julien
authors.initials: J
authors.lastname: Mariethoz
authors.affiliation: Glycoinformatics Inc., Great Falls, VA, USA.
authors.forename: Khaled
authors.initials: K
authors.lastname: Khatib
authors.affiliation: Proteome Informatics Group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland Department of Computer Science, University of Geneva, Geneva, Switzerland.
authors.forename: Davide
authors.initials: D
authors.lastname: Alocci
authors.affiliation: Biomolecular Frontiers Research Centre, Macquarie University, North Ryde, NSW, Australia.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Campbell
authors.affiliation: University of Gothenburg, Sahlgrenska Academy, Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Gothenburg, Sweden.
authors.forename: Niclas G
authors.initials: NG
authors.lastname: Karlsson
authors.affiliation: Biomolecular Frontiers Research Centre, Macquarie University, North Ryde, NSW, Australia.
authors.forename: Nicolle H
authors.initials: NH
authors.lastname: Packer
authors.affiliation: The MITRE Corporation, McLean, VA, USA.
authors.forename: Elaine H
authors.initials: EH
authors.lastname: Mullen
authors.affiliation: Proteome Informatics Group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland Department of Computer Science, University of Geneva, Geneva, Switzerland frederique.lisacek@isb-sib.ch.
authors.forename: Frederique
authors.initials: F
authors.lastname: Lisacek
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D062126:Databases, Chemical; D054884:Host-Pathogen Interactions; D037102:Lectins / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D037102:Lectins; D008024:Ligands; D011134:Polysaccharides; D014764:Viral Proteins