title: Evaluation of Xerostomia and salivary flow rate in Hashimoto's Thyroiditis.
abstract: BACKGROUND
  One of the most common causes of hypothyroidism is Hashimoto's Thyroiditis (HT). Early detection of dry mouth is critical in preserving and promoting systemic and oral health. In this study we have assessed, for the first time, salivary function and xerostomia in HT patients who have not been involved with Sjögren's syndrome.
  
  
  METHODS
  HT was diagnosed in 40 patients based on clinical findings and positive anti-thyroid peroxidase antibodies (anti-TPO). Controls, matched by sex, age and body mass index (BMI), and with no history of thyroid disease, were selected. A questionnaire was used for diagnosis of xerostomia. Saliva samples were taken between 8 a.m. and 9 a.m., and at least 2 hours after the last intake of food or drink. The flow rate was calculated in milliliters per minute.
  
  
  RESULTS
  Xerostomia was significantly higher in patients with HT. Unstimulated salivary flow rate was significantly lower in the HT group. Stimulated salivary flow rate was lower in HT group, but the difference was not significant.
  
  
  CONCLUSIONS
  The patients with HT experienced xerostomia, and their salivary flow rate was diminished. Spitting the saliva then assessing salivary flow rate based on milliliter per minute is non-invasive, fast, and simple for chair-side diagnosis of dry mouth. Autoimmune diseases can be accompanied by salivary gland dysfunction. This may be due to the effect of cytokines in the autoimmune process or because of thyroid hormone dysfunctions.
authors.affiliation: Dental Research Center / Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran, aghahose@sina.tums.ac.ir.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Agha-Hosseini
authors.forename: Nooshin
authors.initials: N
authors.lastname: Shirzad
authors.forename: Mahdieh-Sadat
authors.initials: MS
authors.lastname: Moosavi
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D050031:Hashimoto Disease / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D012472:Salivation; D014987:Xerostomia / Q000209:etiology* / Q000503:physiopathology*