title: Lesions of uncertain malignant potential in the breast (B3): what do we know?
abstract: Breast lesions classified as of uncertain malignant potential (B3) on biopsy form a diverse group of abnormalities, which pose a diagnostic and management challenge. In this paper, we discuss the imaging and pathology features as well as the management of the most controversial B3 lesions, consisting of papillary lesions, complex sclerosing lesions/radial scars, lobular intraepithelial neoplasia, and atypical epithelial proliferation of ductal type. As there is an association with malignancy at the time of diagnosis, as well as an increase in the risk of subsequent development of cancer, a multidisciplinary discussion is almost always required to tailor treatment.
authors.affiliation: Breast Unit, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK.
authors.forename: H N
authors.initials: HN
authors.lastname: Purushothaman
authors.affiliation: Park Centre for Breast Care, Brighton and Sussex University Hospitals NHS Trust, 177 Preston Road, Brighton BN1 6AG, UK. Electronic address: Katerina.Lekanidi@bsuh.nhs.uk.
authors.forename: K
authors.initials: K
authors.lastname: Lekanidi
authors.affiliation: Breast Unit, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK.
authors.forename: S
authors.initials: S
authors.lastname: Shousha
authors.affiliation: Breast Unit, The Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK.
authors.forename: R
authors.initials: R
authors.lastname: Wilson
mesh_terms: D001706:Biopsy; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography