title: Correlation between criteria of diagnosis of low bone mineral density in adult and pediatric thalassemic patients: a prospective study.
abstract: BACKGROUND
  Finding the correlation between criteria for low bone mineral density (BMD) in adulthood and childhood is a matter of interest. This study aimed to find how many of thalassemic patients with Z-Score ≤-2 during childhood, will be found with T-Score ≤-2.5 or Z-Score ≤-2.0 in adulthood.
  
  
  METHODS
  The results of BMDs (one in childhood and one in adulthood) of 30 patients with beta thalassemia major (12 males and 18 females) with mean age of 17.63 y/o in childhood and 20.67 y/o in adulthood were studied, retrospectively. A Norland XR-46 device was used for measuring BMD.
  
  
  RESULTS
  Z-Score ≤-2 was found in 33% of children and T-Score ≤-2.5 and Z-Score ≤-2.0 was found in 43 and 66% of adults, respectively. Correlation of pediatric Z-scores was good with adult T-scores and Z-scores (0.699-0.833). Relation of low BMD diagnosis in pediatric and adults was significant, and Kappa showed a moderate to good correlation between criteria for low BMD in childhood and adulthood, both with special significance in femoral region (8.10-14.47 and 0.258-0.703, respectively). Z-score ≤-2 significantly increased risk of low BMD in adulthood only when T-Score ≤-2.5 was used as low BMD criteria in adulthood (6.2-15.7). More patients dropped to poorer diagnosis group when Z-Score ≤-2.0 was used as low BMD criteria in adulthood.
  
  
  CONCLUSIONS
  There is a moderate to good agreement of these criteria, at least in femoral region but using T-Score ≤-2.5 as low BMD criteria in adulthood caused a better prediction power for Z-Score ≤-2 of childhood.
authors.affiliation: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Mohseni
authors.affiliation: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Mohajeri-Tehrani
authors.affiliation: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.affiliation: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran - fb_sw@yahoo.com.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Hamidi
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000367:Age Factors; D015519:Bone Density; D005260:Female; D005269:Femur; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D055815:Young Adult; D017086:beta-Thalassemia / Q000150:complications*