title: Decreased long- and short-range functional connectivity at rest in drug-naive major depressive disorder.
abstract: BACKGROUND
  Abnormal functional connectivity has been observed in major depressive disorder. Anatomical distance may affect functional connectivity in patients with major depressive disorder. However, whether and how anatomical distance affects functional connectivity at rest remains unclear in drug-naive patients with major depressive disorder.
  
  
  METHODS
  Forty-four patients with major depressive disorder, as well as 44 age-, sex- and education-matched healthy controls, underwent resting-state functional magnetic resonance imaging scanning. Regional functional connectivity strength was calculated for each voxel in the whole brain, which was further divided into short- and long-range functional connectivity strength.
  
  
  RESULTS
  The patients showed decreased long-range positive functional connectivity strength in the right inferior parietal lobule, as well as decreased short-range positive functional connectivity strength in the right insula and right superior temporal gyrus relative to those of the controls. No significant correlations existed between abnormal functional connectivity strength and the clinical variables of the patients.
  
  
  CONCLUSIONS
  The findings revealed that anatomical distance decreases long- and short-range functional connectivity strength in patients with major depressive disorder, which may underlie the neurobiology of major depressive disorder.
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, China guowenbin76@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, China.
authors.forename: Jindong
authors.initials: J
authors.lastname: Chen
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, China.
authors.forename: Renrong
authors.initials: R
authors.lastname: Wu
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors.forename: Miaoyu
authors.initials: M
authors.lastname: Yu
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xue
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, China.
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D063132:Connectome / Q000379:methods*; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D055815:Young Adult
keywords: Major depressive disorder; anatomical distance; default-mode network; functional connectivity; insula