title: WormBase 2016: expanding to enable helminth genomic research.
abstract: WormBase (www.wormbase.org) is a central repository for research data on the biology, genetics and genomics of Caenorhabditis elegans and other nematodes. The project has evolved from its original remit to collect and integrate all data for a single species, and now extends to numerous nematodes, ranging from evolutionary comparators of C. elegans to parasitic species that threaten plant, animal and human health. Research activity using C. elegans as a model system is as vibrant as ever, and we have created new tools for community curation in response to the ever-increasing volume and complexity of data. To better allow users to navigate their way through these data, we have made a number of improvements to our main website, including new tools for browsing genomic features and ontology annotations. Finally, we have developed a new portal for parasitic worm genomes. WormBase ParaSite (parasite.wormbase.org) contains all publicly available nematode and platyhelminth annotated genome sequences, and is designed specifically to support helminth genomic research.
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK kevin.howe@wormbase.org.
authors.forename: Kevin L
authors.identifier: http://orcid.org/0000-0002-1751-9226
authors.initials: KL
authors.lastname: Howe
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Bruce J
authors.identifier: http://orcid.org/0000-0002-6536-0950
authors.initials: BJ
authors.lastname: Bolt
authors.affiliation: Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
authors.forename: Scott
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authors.lastname: Cain
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Juancarlos
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authors.lastname: Chan
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Wen J
authors.initials: WJ
authors.lastname: Chen
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
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authors.lastname: Davis
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: James
authors.initials: J
authors.lastname: Done
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Down
authors.affiliation: Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
authors.forename: Sibyl
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authors.lastname: Gao
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Grove
authors.affiliation: Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
authors.forename: Todd W
authors.initials: TW
authors.lastname: Harris
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Kishore
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Raymond
authors.initials: R
authors.lastname: Lee
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Jane
authors.initials: J
authors.lastname: Lomax
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Yuling
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authors.lastname: Li
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Hans-Michael
authors.initials: HM
authors.lastname: Muller
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Nakamura
authors.affiliation: Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
authors.forename: Paulo
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authors.lastname: Nuin
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Paulini
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Raciti
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Schindelman
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Eleanor
authors.initials: E
authors.lastname: Stanley
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Tuli
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Van Auken
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wang
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Gary
authors.initials: G
authors.lastname: Williams
authors.affiliation: Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
authors.forename: Adam
authors.initials: A
authors.lastname: Wright
authors.affiliation: Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Yook
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Berriman
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Paul
authors.identifier: http://orcid.org/0000-0002-7054-800X
authors.initials: P
authors.lastname: Kersey
authors.affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: Schedl
authors.affiliation: Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
authors.forename: Lincoln
authors.initials: L
authors.lastname: Stein
authors.affiliation: Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Sternberg
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D030541:Databases, Genetic; D017238:Genes, Helminth; D049751:Genome, Helminth; D023281:Genomics; D058977:Molecular Sequence Annotation; D009348:Nematoda / Q000235:genetics*; D010986:Platyhelminths / Q000235:genetics; D012984:Software