title: High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis.
abstract: Our study examined the relationship between the expression of matrix metalloproteinases (MMP)-1, MMP-2, and MMP-9 proteins and the pathogenesis of osteoarthritis (OA). We employed rigorous inclusion and exclusion criteria in computer-based bibliographic databases to extract published studies relevant to this investigation. The STATA 12.0 software was used for the statistical analyses. A total of 1408 studies were initially searched, and 10 studies with 458 OA patients and 295 healthy controls were included in this meta-analysis. The meta-analysis results suggested that the protein levels of MMP-1, MMP-2, and MMP-9 were higher in patients with OA than those in the control group. A subgroup analysis according to ethnicity showed that the protein levels of MMP-1 and MMP-2 were higher in Asian patients with OA than in controls. Caucasians showed no statistically significant differences in protein expression of MMP-1 and MMP-2 between the OA patient group and the control group. Interestingly, the protein levels of MMP-9 in patients with OA were higher than those in the control group in both Asians and Caucasians. A sample-source analysis suggested that the serum levels of MMP-2 and MMP-9 proteins were higher in patients with OA than in controls, while MMP-1 and MMP-9 protein expressions were higher in the synovial joint fluid of patients with OA than in controls. In conclusion, our meta-analysis results suggested that the increased expression of MMP-1, MMP-2, and MMP-9 proteins might be associated with the pathogenesis of OA.
authors.affiliation: Department of Trauma and Orthopedics, The 425th Hospital of PLA, Sanya, Hainan China.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Zeng
authors.affiliation: Department of Trauma and Orthopedics, The 425th Hospital of PLA, Sanya, Hainan China.
authors.forename: A B
authors.initials: AB
authors.lastname: Chen
authors.affiliation: Department of Trauma and Orthopedics, The 425th Hospital of PLA, Sanya, Hainan China.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Trauma and Orthopedics, The 425th Hospital of PLA, Sanya, Hainan China.
authors.forename: J H
authors.initials: JH
authors.lastname: Song
authors.affiliation: Department of Trauma and Orthopedics, The 425th Hospital of PLA, Sanya, Hainan China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Gao
mesh_terms: D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D010003:Osteoarthritis / Q000097:blood* / Q000473:pathology; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1