title: Fatal Disseminated Aspergillus penicillioides Infection in a 3-Month-Old Infant with Suspected Cystic Fibrosis: Autopsy Case Report with Review of Literature.
abstract: Patients with cystic fibrosis (CF) often are colonized by Aspergillus species in their respiratory tract, but invasive aspergillosis is a rare complication. We describe the autopsy findings of an infant with cystic fibrosis who had fatal disseminated aspergillosis. The causative agent was identified as A. penicillioides by molecular technique. To our knowledge, this is the first report of disseminated aspergillosis caused by A. penicillioides in any type of patient. The literature on invasive aspergillosis in patients with cystic fibrosis also is reviewed.
authors.affiliation: 1 Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Kirti
authors.initials: K
authors.lastname: Gupta
authors.affiliation: 1 Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Parikshaa
authors.initials: P
authors.lastname: Gupta
authors.affiliation: 2 Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Mathew
authors.affiliation: 2 Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Bansal
authors.affiliation: 3 Department of Medical Mycology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Gangandeep
authors.initials: G
authors.lastname: Singh
authors.affiliation: 2 Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Meenu
authors.initials: M
authors.lastname: Singh
authors.affiliation: 3 Department of Medical Mycology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Arunaloke
authors.initials: A
authors.lastname: Chakrabarti
mesh_terms: D001228:Aspergillosis / Q000150:complications* / Q000382:microbiology / Q000473:pathology*; D001230:Aspergillus; D001344:Autopsy; D003550:Cystic Fibrosis / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D008297:Male
keywords: autopsy; cystic fibrosis; disseminated; invasive aspergillosis