title: The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD).
abstract: BACKGROUND
  Aspirin-exacerbated respiratory disease (AERD) consists of a classic tetrad: moderate/severe asthma, chronic rhinosinusitis, nasal polyps, and intolerance to aspirin or other nonsteroidal anti-inflammatory drugs. Clinical control with drugs, surgery, and desensitization are treatment options.
  
  
  OBJECTIVE
  To evaluate the efficacy and tolerability of aspirin desensitization in patients with AERD.
  
  
  METHODS
  Periodic symptom assessment and endoscopy in patients with AERD undergoing surgery who were desensitized.
  
  
  RESULTS
  Seventeen patients were desensitized. Eight patients completed the desensitization and were followed for a minimum of a one-year period (mean 3.1 years). These patients showed improvement in all symptoms. Moreover, surgical reassessment was not indicated in any of these patients and there was a decrease in costs with medication and procedures. Eight patients did not complete desensitization, mainly due to procedure intolerance and uncontrolled asthma, whereas another patient was lost to follow-up.
  
  
  CONCLUSIONS
  Aspirin desensitization, when tolerated, was effective in patients with AERD and with poor clinical/surgical response.
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Jonas Willian
authors.initials: JW
authors.lastname: Spies
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Fabiana Cardoso Pereira
authors.initials: FC
authors.lastname: Valera
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Daniel Loiola
authors.initials: DL
authors.lastname: Cordeiro
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Taís Nociti
authors.initials: TN
authors.lastname: de Mendonça
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Marcelo Gonçalves Junqueira
authors.initials: MG
authors.lastname: Leite
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Edwin
authors.initials: E
authors.lastname: Tamashiro
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Luiza Karla
authors.initials: LK
authors.lastname: Arruda
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil. Electronic address: wtalima@fmrp.usp.br.
authors.forename: Wilma Terezinha
authors.initials: WT
authors.lastname: Anselmo-Lima
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D055963:Asthma, Aspirin-Induced / Q000276:immunology / Q000628:therapy*; D002908:Chronic Disease; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*; D012220:Rhinitis / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*; D012852:Sinusitis / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: Aspirin; Aspirina; Desensitization immunological; Dessensibilização imunológica; Nasal polyps; Polipose nasal; Sinusite; Sinusitis