title: Primary Diffuse Large B-cell Lymphoma involving the Mandible.
abstract: Lymphomas of the oral cavity are rare and typically present as intraosseous lesions that are most commonly diffuse large B-cell type. Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma histologically characterized by diffuse proliferation of large neoplastic B-lymphoid cells with a nuclear size equal to or exceeding normal histiocytic nuclei. A case of DLBCL of the mandible in an 18 years old male patient is presented. This report discusses this rare malignancy, including clinical presentation, histopathologic features, immunologic profile, treatment and prognosis. Though lymphoma of mandible is rare, it must be considered in differential diagnosis of swellings arising in the region.
authors.affiliation: Board Resident, Department of Oral and Maxillofacial Surgery, King Fahad Medical City, Riyadh, Saudi Arabia, Phone: +966 56 444 4402, e-mail: ksucod@gmail.com.
authors.forename: Faleh Ali A
authors.initials: FA
authors.lastname: Alshahrani
authors.affiliation: Department of Oral and Maxillofacial Surgery, Head and Neck Surgical Oncology, King Fahad Medical City, Riyadh Saudi Arabia.
authors.forename: Abdulsalam S
authors.initials: AS
authors.lastname: Aljabab
authors.affiliation: Department of Adult Hematology and Blood Marrow Transplant, King Fahad Medical City, Riyadh, Saudi Arabia.
authors.forename: Ibraheem Hm
authors.initials: IH
authors.lastname: Motabi
authors.affiliation: Department of Radiology, Unit of Neuroradiology, King Fahad Medical City, Riyadh, Saudi Arabia.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Alrashed
authors.affiliation: Department of Dental Health, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Sukumaran
authors.initials: S
authors.lastname: Anil
mesh_terms: D000293:Adolescent; D002467:Cell Nucleus; D003937:Diagnosis, Differential; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008334:Mandible; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000628:therapy
keywords: B-cell lymphoma; Diffuse large B-cell lymphoma; Intraosseous lymphoma; Mandible; Non-Hodgkin’s lymphoma