title: Hematopoietic cell transplantation for adults with acute myeloid leukemia with minimal residual disease.
abstract: Early trials of hematopoietic cell transplantation (HCT) for adults with acute myeloid leukemia (AML) did not generally include measurement of minimal residual disease (MRD) at the time of remission. However, the presence of MRD is now considered to be a powerful predictor of outcome for adults with AML in first complete remission. This raises the question of whether MRD positivity in first remission changes the indications for transplant or the transplant approach itself if patients do proceed to transplant with MRD present. This paper will begin to address these issues in adult AML.
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Division of Medical Oncology, University of Washington School of Medicine, 1100 Fairview Avenue North, D5-310, P.O. Box 19024, Seattle, WA 98109-1024, USA. Electronic address: fappelba@fhcrc.org.
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Appelbaum
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D050660:Core Binding Factors / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D019653:Myeloablative Agonists / Q000627:therapeutic use; D018365:Neoplasm, Residual; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D016019:Survival Analysis; D014178:Translocation, Genetic; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous
chemical_list: D000970:Antineoplastic Agents; D050660:Core Binding Factors; D019653:Myeloablative Agonists
keywords: Acute myeloid leukemia; Hematopoeitic cell transplantation; Minimal residual disease