title: High Recovery Rate of Non-albicans Candida Species Isolated From Burn Patients With Candidemia in Iran.
abstract: BACKGROUND
  Blood stream infections (BSIs) are major causes of morbidity and mortality in burn patients. Microorganisms responsible for BSI are generally bacteria; however, Candida spp. are the infection agents in as many as 8% of all cases. Burn wound colonization and infections are generally the first steps to systemic infection. Candidemia in burn patients has been associated with high mortality and a prolonged hospital stay.
  
  
  OBJECTIVE
  Candidemia in burn patients has been defined as a preterminal event, leading to high morbidity and mortality rates among these patients. The aim of this study was to establish the incidence of candidemia in burn patients in Iran.
  
  
  METHODS
  We consecutively collected 405 blood samples from 113 burn patients. The yeast isolates were identified to the species level using conventional procedures. In vitro antifungal susceptibility of the Candida isolates to amphotericin B, fluconazole, voriconazole and caspofungin was performed using the Etest.
  
  
  RESULTS
  Twenty-seven samples (6.7%) of the blood cultures from 13 patients (12%) were positive for Candida species. Candida parapsilosis (38%) and C. tropicalis (38%) were the most commonly found Candida species, followed by C. albicans (15%) and C. guilliermondii (15%) in the patients. The incidence of candidemia was significantly correlated with increased duration of hospitalization, increased time of stay in the intensive care unit, and higher mortality. The antifungal susceptibility tests demonstrated that amphotericin B and voriconazole had the lowest minimum inhibitory concentrations (MICs) against Candida spp.
  
  
  CONCLUSIONS
  Non-albicans Candida should be considered as significant pathogens in burned patients with candidemia.
authors.affiliation: Department of Medical Mycology, Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, IR Iran ; Department of Medical Mycology and Parasitology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Lotfi
authors.affiliation: Department of Medical Mycology and Parasitology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Shokohi
authors.affiliation: Burn Center, Zare Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran.
authors.forename: Seyed Zahra
authors.initials: SZ
authors.lastname: Nouranibaladezaei
authors.affiliation: Department of Medical Mycology, Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, IR Iran.
authors.forename: Ayatollah
authors.initials: A
authors.lastname: Nasrolahi Omran
authors.affiliation: Department of Infectious Disease, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Nahid
authors.initials: N
authors.lastname: Kondori
keywords: Burn Patients; Burns; Candida, Candidemia; Diagnosis; Iran; Non-albicans Candida; in vitro Antifungal Susceptibility