title: Tissue engineering strategies for promoting vascularized bone regeneration.
abstract: This review focuses on current tissue engineering strategies for promoting vascularized bone regeneration. We review the role of angiogenic growth factors in promoting vascularized bone regeneration and discuss the different therapeutic strategies for controlled/sustained growth factor delivery. Next, we address the therapeutic uses of stem cells in vascularized bone regeneration. Specifically, this review addresses the concept of co-culture using osteogenic and vasculogenic stem cells, and how adipose derived stem cells compare to bone marrow derived mesenchymal stem cells in the promotion of angiogenesis. We conclude this review with a discussion of a novel approach to bone regeneration through a cartilage intermediate, and discuss why it has the potential to be more effective than traditional bone grafting methods.
authors.affiliation: Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States; UCSF-UCB Masters of Translational Medicine Program, Berkeley and San Francisco, CA, United States.
authors.forename: Sarah
authors.initials: S
authors.lastname: Almubarak
authors.affiliation: Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States; UCSF-UCB Masters of Translational Medicine Program, Berkeley and San Francisco, CA, United States.
authors.forename: Hubert
authors.initials: H
authors.lastname: Nethercott
authors.affiliation: Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States; UCSF-UCB Masters of Translational Medicine Program, Berkeley and San Francisco, CA, United States.
authors.forename: Marie
authors.initials: M
authors.lastname: Freeberg
authors.affiliation: Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States; UCSF-UCB Masters of Translational Medicine Program, Berkeley and San Francisco, CA, United States.
authors.forename: Caroline
authors.initials: C
authors.lastname: Beaudon
authors.affiliation: Departments of Bioengineering, and Material Science and Engineering, University of California, Berkeley (UCB), Berkeley, CA, United States.
authors.forename: Amit
authors.initials: A
authors.lastname: Jha
authors.affiliation: Departments of Bioengineering, and Material Science and Engineering, University of California, Berkeley (UCB), Berkeley, CA, United States.
authors.forename: Wesley
authors.initials: W
authors.lastname: Jackson
authors.affiliation: Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States.
authors.forename: Ralph
authors.initials: R
authors.lastname: Marcucio
authors.affiliation: Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States.
authors.forename: Theodore
authors.initials: T
authors.lastname: Miclau
authors.affiliation: Departments of Bioengineering, and Material Science and Engineering, University of California, Berkeley (UCB), Berkeley, CA, United States.
authors.forename: Kevin
authors.initials: K
authors.lastname: Healy
authors.affiliation: Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, United States; Departments of Bioengineering, and Material Science and Engineering, University of California, Berkeley (UCB), Berkeley, CA, United States. Electronic address: Chelsea.Bahney@UCSF.edu.
authors.forename: Chelsea
authors.initials: C
authors.lastname: Bahney
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D002986:Clinical Trials as Topic; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D018919:Neovascularization, Physiologic; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: Angiogenesis; Bone regeneration; Controlled release; Endochondral ossification; Osteogenesis; Stem cells