title: [The regulation of CTLA4-Ig in bone and cartilage destruction of rheumatoid arthritis].
abstract: CTLA4-Ig is a regulator of co-stimulation and inhibits the activation of T cells through interfering with the interaction of CD80/86 on antigen-presenting cells with CD28. Recently CTLA4-Ig has shown additional effect beyond T cell inhibition, such as direct inhibition of differentiation of osteoclast, enhancement of osteogenesis. These effects may contribute to prevention of bone destruction in rheumatoid arthritis.
authors.affiliation: Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Iwamoto
authors.affiliation: Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D001847:Bone Diseases / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D060908:CTLA-4 Antigen / Q000276:immunology*; D002357:Cartilage Diseases / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*
chemical_list: D060908:CTLA-4 Antigen; D007136:Immunoglobulins