title: Columnar deformation of human red blood cell by highly localized fiber optic Bessel beam stretcher.
abstract: A single human red blood cell was optically stretched along two counter-propagating fiber-optic Bessel-like beams in an integrated lab-on-a-chip structure. The beam enabled highly localized stretching of RBC, and it induced a nonlinear mechanical deformation to finally reach an irreversible columnar shape that has not been reported. We characterized and systematically quantified this optically induced mechanical deformation by the geometrical aspect ratio of stretched RBC and the irreversible stretching time. The proposed RBC mechanism can realize a versatile and compact opto-mechanical platform for optical diagnosis of biological substances in the single cell level.
authors.affiliation: Photonic Device Physics Laboratory, Department of physics, Yonsei University, Seoul 120-749, South Korea.
authors.forename: Sungrae
authors.initials: S
authors.lastname: Lee
authors.affiliation: Photonic Device Physics Laboratory, Department of physics, Yonsei University, Seoul 120-749, South Korea.
authors.forename: Boram
authors.initials: B
authors.lastname: Joo
authors.affiliation: Electron Device Laboratory, Department of physics, Yonsei University, Seoul 120-749, South Korea.
authors.forename: Pyo Jin
authors.initials: PJ
authors.lastname: Jeon
authors.affiliation: Electron Device Laboratory, Department of physics, Yonsei University, Seoul 120-749, South Korea.
authors.forename: Seongil
authors.initials: S
authors.lastname: Im
authors.affiliation: Photonic Device Physics Laboratory, Department of physics, Yonsei University, Seoul 120-749, South Korea.
authors.forename: Kyunghwan
authors.initials: K
authors.lastname: Oh
keywords: (060.2310) Fiber optics; (060.2370) Fiber optics sensors; (130.3990) Micro-optical devices; (350.4855) Optical tweezers or optical manipulation