title: Prospects for Broadly Protective Influenza Vaccines.
abstract: The development of vaccines that could provide broad protection against antigenically variant influenza viruses has long been the ultimate prize in influenza research. Recent developments have pushed us closer to this goal, and such vaccines may now be within reach. This brief review outlines the current approaches to broadly protective vaccines, and the probable hurdles and roadblocks to achieving this goal.
authors.affiliation: Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Elmwood Avenue, Rochester, NY 14642, United States. Electronic address: john_treanor@urmc.rochester.edu.
authors.forename: John Jay
authors.initials: JJ
authors.lastname: Treanor
mesh_terms: D000277:Adjuvants, Pharmaceutic; D000281:Administration, Intranasal; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D006384:Hemagglutination / Q000276:immunology; D006388:Hemagglutinins / Q000276:immunology*; D006801:Humans; D009439:Neuraminidase / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000277:Adjuvants, Pharmaceutic; D015704:CD4 Antigens; D016827:CD8 Antigens; D006388:Hemagglutinins; D014759:Viral Envelope Proteins; D014765:Viral Vaccines; D009439:Neuraminidase