title: [Antiteratogenic capacity of resveratrol in streptozotocin-induced diabetes in rats].
abstract: OBJECTIVE
  To evaluate the anti-hyperglycemic and anti-teratogenic capacity of resveratrol in streptozotocin-induced diabetic rats.
  
  
  METHODS
  Experimental study. There were three groups, of five rats each; two groups were treated with a single dose of 50 mg/Kg of streptozotocin (STZ), in citrate buffer, at the 4th day of gestation, and the third group was considered the control, and were administered with citrate buffer only. One of the two STZ induced groups was administered with 100 mg/Kg resveratrol the days 8th to 12th, when neurulation occurs. Fetuses were obtained the 19th gestational day, and were subjected to morphologic analysis; and in fetal liver the activities of scavenging enzymes catalase, superoxide dismutase and gluthathione peroxidase were measured.
  
  
  RESULTS
  Resveratrol can decrease the teratogenic effect of STZ-induced diabetes, and scavenging activities were beneficed by the administration of this antioxidant.
  
  
  CONCLUSIONS
  Resveratrol shown embryoprotective properties mediated by amelioration of oxidative stress produced by maternal hyperglycemia.
authors.affiliation: Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Estado de México, México.
authors.forename: Ninna Leslie
authors.initials: NL
authors.lastname: Trejo-González
authors.affiliation: Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Estado de México, México.
authors.forename: Gladys
authors.initials: G
authors.lastname: Chirino-Galindo
authors.affiliation: Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Estado de México, México.
authors.forename: Martín
authors.initials: M
authors.lastname: Palomar-Morales
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants; D002374:Catalase; D003921:Diabetes Mellitus, Experimental; D018384:Oxidative Stress; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013311:Streptozocin
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D013267:Stilbenes; D013311:Streptozocin; D002374:Catalase; D000077185:Resveratrol