title: Oriented cell division: new roles in guiding skin wound repair and regeneration.
abstract: Tissue morphogenesis depends on precise regulation and timely co-ordination of cell division and also on the control of the direction of cell division. Establishment of polarity division axis, correct alignment of the mitotic spindle, segregation of fate determinants equally or unequally between daughter cells, are essential for the realization of oriented cell division. Furthermore, oriented cell division is regulated by intrinsic cues, extrinsic cues and other cues, such as cell geometry and polarity. However, dysregulation of cell division orientation could lead to abnormal tissue development and function. In the present study, we review recent studies on the molecular mechanism of cell division orientation and explain their new roles in skin repair and regeneration.
authors.affiliation: Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P. R. China Key Research Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Affiliated Hospital to the Chinese PLA General Hospital, 51 Fu Cheng Road, Beijing 100048, P.R. China.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Yang
authors.affiliation: Key Research Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Affiliated Hospital to the Chinese PLA General Hospital, 51 Fu Cheng Road, Beijing 100048, P.R. China.
authors.forename: Kui
authors.initials: K
authors.lastname: Ma
authors.affiliation: Key Research Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Affiliated Hospital to the Chinese PLA General Hospital, 51 Fu Cheng Road, Beijing 100048, P.R. China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Geng
authors.affiliation: Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P. R. China yanzisun1979@sina.com fuxiaobing@vip.sina.com.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Sun
authors.affiliation: Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P. R. China Key Research Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Affiliated Hospital to the Chinese PLA General Hospital, 51 Fu Cheng Road, Beijing 100048, P.R. China yanzisun1979@sina.com fuxiaobing@vip.sina.com.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fu
mesh_terms: D002455:Cell Division / Q000235:genetics*; D016764:Cell Polarity / Q000235:genetics*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D009024:Morphogenesis / Q000235:genetics; D012038:Regeneration / Q000235:genetics*; D012867:Skin / Q000254:growth & development*; D008941:Spindle Apparatus / Q000235:genetics; D014945:Wound Healing
keywords: division axis; oriented cell division; spindle orientation; wound healing