title: Quantitative assessment of the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive system cancer risk.
abstract: The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been reported to be associated with digestive system cancer; however, the results from previous studies have been conflicting. The present study aimed to investigate the association between the ACE I/D polymorphism and the risk of digestive system cancer using a meta-analysis of previously published studies. Databases were systematically searched to identify relevant studies published prior to December 2014. We estimated the pooled OR with its 95%CI to assess the association. The meta-analysis consisted of thirteen case-control studies that included 2557 patients and 4356 healthy controls. Meta-analysis results based on all the studies showed no significant association between the ACE I/D polymorphism and the risk of digestive system cancer (DD vs II: OR = 0.85, 95%CI = 0.59-1.24; DI vs II: OR = 0.94, 95%CI = 0.78-1.15; dominant model: OR = 0.96, 95%CI = 0.81- 1.15; recessive model: OR = 1.06, 95%CI = 0.76-1.48). Subgroup analyses by race and cancer type did not detect an association between the ACE I/D polymorphism and digestive system cancer risk. However, when the analyses were restricted to smaller studies (N < 500 patients), the summary OR of DI vs II was 0.80 (95%CI = 0.66-0.97). Our analyses detected a possibility of publication bias with a misestimate of the true association by smaller studies. Overall, meta-analysis results suggest the ACE I/D polymorphism might not be associated with susceptibility to digestive system cancer. Further large and well-designed studies are needed to confirm these conclusions.
authors.affiliation: Department of General Surgery, HuaShan Hospital, Fudan University School of Medicine, Shanghai, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of General Surgery, HuaShan Hospital, Fudan University School of Medicine, Shanghai, China.
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of General Surgery, HuaShan Hospital, Fudan University School of Medicine, Shanghai, China.
authors.forename: F H
authors.initials: FH
authors.lastname: Guo
authors.affiliation: Department of General Surgery, HuaShan Hospital, Fudan University School of Medicine, Shanghai, China.
authors.forename: X
authors.initials: X
authors.lastname: Mao
authors.affiliation: Department of General Surgery, HuaShan Hospital, Fudan University School of Medicine, Shanghai, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, HuaShan Hospital, Fudan University School of Medicine, Shanghai, China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Dong
authors.affiliation: Department of General Surgery, HuaShan Hospital, Fudan University School of Medicine, Shanghai, China wang19701010@126.com.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Wang
authors.affiliation: Department of General Surgery, HuaShan Hospital, Fudan University School of Medicine, Shanghai, China.
authors.forename: F
authors.initials: F
authors.lastname: Luo
mesh_terms: D016022:Case-Control Studies; D004067:Digestive System Neoplasms / Q000201:enzymology / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A