title: Prostate Cancer Stem Cells: Research Advances.
abstract: Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve the prognosis for patients with advanced stages of the disease.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, H. Jordana 19, 41-808 Zabrze, Poland. djaworska@sum.edu.pl.
authors.forename: Dagmara
authors.initials: D
authors.lastname: Jaworska
authors.affiliation: Department of Microbiology and Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, H. Jordana 19, 41-808 Zabrze, Poland. wkrol@sum.edu.pl.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Król
authors.affiliation: Department of Microbiology and Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, H. Jordana 19, 41-808 Zabrze, Poland. eszliszka@sum.edu.pl.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Szliszka
mesh_terms: D000818:Animals; D015415:Biomarkers; D002471:Cell Transformation, Neoplastic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D015398:Signal Transduction; D055153:Stem Cell Niche
chemical_list: D015415:Biomarkers
keywords: cancer stem cell; castration-resistant prostate cancer; metastasis; prostate cancer