title: Gestational surrogacy and the role of routine embryo screening: Current challenges and future directions for preimplantation genetic testing.
abstract: Preimplantation genetic screening (PGS) is a component of IVF entailing selection of an embryo for transfer on the basis of chromosomal normalcy. If PGS were integrated with single embryo transfer (SET) in a surrogacy setting, this approach could improve pregnancy rates, minimize miscarriage risk, and limit multiple gestations. Even without PGS, pregnancy rates for IVF surrogacy cases are generally satisfactory, especially when treatment utilizes embryos derived from young oocytes and transferred to a healthy surrogate. However, there could be a more general role for PGS in surrogacy, since background aneuploidy in embryos remains a major factor driving implantation failure and miscarriage for all infertility patients. At present, the proportion of IVF cases involving GS is limited, while the number of IVF patients requesting PGS appears to be increasing. In this report, the relevance of PGS for surrogacy in the rapidly changing field of assisted fertility medicine is discussed.
authors.affiliation: Reproductive Research Section, Center for Advanced Genetics, Carlsbad, California.|Faculty of Applied Biotechnology, School of Life Sciences, University of Westminster, London, United Kingdom.
authors.forename: E Scott
authors.initials: ES
authors.lastname: Sills
authors.affiliation: Southern California Center for Reproductive Medicine, Newport Beach, California.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Anderson
authors.affiliation: The Scotia Clinic, Tralee, County Kerry, Ireland.
authors.forename: Mary
authors.initials: M
authors.lastname: McCaffrey
authors.affiliation: Division of Analytics & Quantitative Research, Rosenblatt Securities Inc, New York, New York.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Reproductive Sciences Center, San Diego, California.|Progenesis, La Jolla, California.
authors.forename: Nabil
authors.initials: N
authors.lastname: Arrach
authors.affiliation: Reproductive Sciences Center, San Diego, California.|Progenesis, La Jolla, California.
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Wood
mesh_terms: D000782:Aneuploidy; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods*; D013533:Gestational Carriers
keywords: IVF; gestational surrogacy; preimplantation genetic screening; single embryo transfer