title: Domino Carbopalladation/C-H Functionalization Sequence: An Expedient Synthesis of Bis-Heteroaryls through Transient Alkyl/Vinyl-Palladium Species Capture.
abstract: A microwave-assisted highly efficient intermolecular domino carbopalladation/C-H functionalization sequence has been developed to access bis-heteroaryl frameworks in a single operation. The reaction involves carbopalladation of the halogenated acrylamides or phenylpropiolamides by the Pd(0) catalysis, followed by the direct (hetero)arylation to give products with good to excellent yields. The synthetic utility of this method was also extended towards the application of the Ugi-adduct as the starting material.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven (Belgium) http://chem.kuleuven.be/en/research/mds/lomac. usharma81@gmail.com.
authors.forename: Upendra K
authors.initials: UK
authors.lastname: Sharma
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven (Belgium) http://chem.kuleuven.be/en/research/mds/lomac.
authors.forename: Nandini
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven (Belgium) http://chem.kuleuven.be/en/research/mds/lomac.|Bioorganic Lab, Department of Chemistry, University of Delhi, Delhi 110007 (India).
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Kumar
authors.affiliation: Bioorganic Lab, Department of Chemistry, University of Delhi, Delhi 110007 (India).
authors.forename: Brajendra K
authors.initials: BK
authors.lastname: Singh
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven (Belgium) http://chem.kuleuven.be/en/research/mds/lomac. erik.vandereycken@chem.kuleuven.be.
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken
keywords: CH activation; domino reactions; heterocycles; microwave chemistry; palladium