title: Driving Adsorbed Gold Nanoparticle Assembly by Merging Lipid Gel/Fluid Interfaces.
abstract: Surface forces between inorganic nanoparticles and lipid bilayer is of great relevance to biophysics, medicine, and nanobiotechnology. Adsorbed nanoparticles may influence the fluidity of the underlying lipids, which may in turn influence nanoparticle assembly. Herein three types of lipids (DOPC, Tc = -20 °C; DMPC, Tc = 23 °C; and DPPC, Tc = 41 °C) are used, all with the same phosphocholine (PC) headgroup. Gold nanoparticle (AuNP) color change is monitored as a function of lipid phase transition temperature (Tc), surface ligands on AuNPs, and temperature. Liposomes with higher fluidity induce much faster aggregation of AuNPs. Aside from the kinetic aspect of faster diffusion on fluid bilayers, this faster color change is attributed to the local lipid gelation and merging of gelled regions to eliminate the interface between different lipid phases.
authors.affiliation: Department of Chemistry and ‡Department of Biology, Waterloo Institute for Nanotechnology , Waterloo, Ontario, Canada N2L 3G1.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Chemistry and ‡Department of Biology, Waterloo Institute for Nanotechnology , Waterloo, Ontario, Canada N2L 3G1.
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Curry
authors.affiliation: Department of Chemistry and ‡Department of Biology, Waterloo Institute for Nanotechnology , Waterloo, Ontario, Canada N2L 3G1.
authors.forename: Juewen
authors.initials: J
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D004058:Diffusion; D005782:Gels; D006046:Gold / Q000737:chemistry*; D007700:Kinetics; D008081:Liposomes / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010713:Phosphatidylcholines / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: D005782:Gels; D008081:Liposomes; D010713:Phosphatidylcholines; D006046:Gold