title: Piroxicam-mediated modulatory action of 5-hydroxytryptamine serves as a "brake" on neuronal excitability in ischemic stroke.
abstract: Our previous studies indicated an increase in extracellular γ-aminobutyric acid (GABA) in rodent's ischemic brain after Piroxicam administration, leading to alleviation of glutamate mediated excitotoxicity through activation of type A GABA receptor (GABAA). This study was to investigate if GABAA activation by Piroxicam affects extracellular 5-hydroxytryptamine or not. High performance liquid chromatography revealed that there was a significant decrease in extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum in Piroxicam pre-treated rat brains. This suggests a probable role of Piroxicam in reducing extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum possibly due to the GABAA activation by Piroxicam.
authors.affiliation: Department of Neurology, Leonard M. Miller School of Medicine, Miami, FL, USA ; School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India.
authors.forename: Pallab
authors.identifier: 0000-0003-2867-1650
authors.initials: P
authors.lastname: Bhattacharya
authors.affiliation: School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India.
authors.forename: Anand Kumar
authors.initials: AK
authors.lastname: Pandey
authors.affiliation: School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India ; Department of Biomedical Engineering, North Eastern Hill University (NEHU), Shillong, India.
authors.forename: Sudip
authors.initials: S
authors.lastname: Paul
authors.affiliation: School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Patnaik
keywords: cerebral cortex; ischemic stroke; nerve regeneration; neuroprotection; piroxicam; serotonin; γ-aminobutyric acid; striatum