title: Cranberries (Oxycoccus quadripetalus) inhibit pro-inflammatory cytokine and chemokine expression in 3T3-L1 adipocytes.
abstract: Oxidative stress and inflammation are involved in the development of obesity, type 2 diabetes and vascular complications. Systemic inflammation, as seen in obesity, is associated with high plasmatic levels of pro-inflammatory, pro-atherogenic and pro-thrombotic adipokines. Here we studied the effects of lyophilized cranberries (LCB) on the secretion and expression of PAI-1, IL-6, MCP-1 and leptin in mature 3T3-L1 adipocytes under baseline conditions and excessive inflammatory response elicitation by stimulation with H2O2. Our data demonstrated that LCB significantly reduced the expression and secretion of IL-6, MCP-1 and leptin, as well as suppressed the overexpression of PAI-1 induced by H2O2. Our findings suggested that LCB counteracted the stimulatory effect of H2O2 on secretion and expression of pro-inflammatory adipokines, implying a potential anti-inflammatory effect during the inflammatory process induced via oxidative stress in adipose tissue.
authors.affiliation: Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland. Electronic address: kaskakow@up.poznan.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kowalska
authors.affiliation: Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland. Electronic address: aolejnik@up.poznan.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Olejnik
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D016207:Cytokines / Q000187:drug effects / Q000378:metabolism*; D005638:Fruit; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced* / Q000188:drug therapy; D020738:Leptin / Q000378:metabolism; D051379:Mice; D028321:Plant Preparations / Q000494:pharmacology*; D058258:Serpin E2 / Q000187:drug effects / Q000378:metabolism; D029796:Vaccinium
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D020738:Leptin; D028321:Plant Preparations; D058258:Serpin E2; C511869:Serpine2 protein, mouse; D006861:Hydrogen Peroxide
keywords: 3T3-L1 adipocytes; Chemokines; Cranberries; Cytokines; Inflammation