title: The Effect of Colchicine on Mean Platelet Volume in Behcet's Disease.
abstract: BACKGROUND
  Patients with Behcet's Disease are recognized to be at an increased risk for venous and/or arterial thrombosis. Colchicine reduces the initiation and amplification of inflammation and is believed to suppress secretion of cytokines and chemokines and in vitro platelet aggregation.
  
  
  OBJECTIVE
  To evaluate the effect of colchicine on levels of mean platelets volume, platelets, erythrocyte sedimentation rate, and C-reactive protein in patients with Behcet's Disease.
  
  
  METHODS
  Patients with Behcet's Disease were evaluated for mean platelets volume before colchicine therapy (Group 1) and after 6-month from beginning of colchicine treatment (Group 2).
  
  
  RESULTS
  Fifty-two subjects were evaluated. The mean age was 38.3 years and the female/male ratio was 28/24=1.16. Laboratory tests were evaluated in Group 1 and Group 2. The median level of mean platelets volume was 9.2±0.8 fl in Group 1 and 8.9±0.9 fl in Group 2. Levels of mean platelets volume was found as significant between Group 1 and 2 (p=0.001).
  
  
  CONCLUSIONS
  Given the proposed relationship between MPV and platelet activity, MPV may serve as a surrogate essay for Behcet's response to colchicine. Colchicine might suppress platelet function and be used in vascular involvement together with immunosuppressant agents in Behcet's Disease. Further studies in large population are needed to evaluate the role of colchicine in platelet function and the effect of colchicine on thrombosis in BD.
authors.affiliation: Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Dermatology, Ankara, Turkey drhaticeartik@gmail.com.
authors.forename: Hatice
authors.initials: H
authors.lastname: Ataş
authors.affiliation: Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Dermatology, Ankara, Turkey.
authors.forename: Bengü Cevirgen
authors.initials: BC
authors.lastname: Cemil
authors.affiliation: Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Dermatology, Ankara, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Canpolat
authors.affiliation: Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Dermatology, Ankara, Turkey.
authors.forename: Müzeyyen
authors.initials: M
authors.lastname: Gönül
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D001799:Blood Sedimentation / Q000187:drug effects; D002097:C-Reactive Protein / Q000032:analysis; D003078:Colchicine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D011446:Prospective Studies; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control
chemical_list: D005343:Fibrinolytic Agents; D002097:C-Reactive Protein; D003078:Colchicine
keywords: Behcet’s disease; Colchicine; Mean platelet volume