title: Copper-catalyzed direct C-H fluoroalkenylation of heteroarenes.
abstract: Copper-catalyzed direct C-H fluoroalkenylation of heterocycles using various gem-bromofluoroalkenes as electrophiles is reported. This efficient method offers step-economical, low-cost and stereocontrolled access to relevant heteroarylated monofluoroalkenes. The synthesis of fluorinated analogues of biomolecules and therapeutic agents for the treatment of Duchenne muscular dystrophy as application is reported.
authors.affiliation: Normandie Univ, COBRA, UMR 6014 & FR 3038, Univ Rouen, INSA Rouen, CNRS, IRCOF, 1 rue Tesnière 76821, Mont-Saint-Aignan Cedex, France. samuel.couve-bonnaire@insa-rouen.fr christophe.hoarau@insa-rouen.fr.
authors.forename: Kevin
authors.initials: K
authors.lastname: Rousée
authors.forename: Cédric
authors.initials: C
authors.lastname: Schneider
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bouillon
authors.forename: Vincent
authors.initials: V
authors.lastname: Levacher
authors.forename: Christophe
authors.initials: C
authors.lastname: Hoarau
authors.forename: Samuel
authors.initials: S
authors.lastname: Couve-Bonnaire
authors.forename: Xavier
authors.initials: X
authors.lastname: Pannecoucke
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000475:Alkenes; D006571:Heterocyclic Compounds; D006845:Hydrocarbons, Fluorinated; D003300:Copper