title: Melatonin enhances vertical bone augmentation in rat calvaria secluded spaces.
abstract: BACKGROUND
  Melatonin has many roles, including bone remodeling and osseointegration of dental implants. The topical application of melatonin facilitated bone regeneration in bone defects. We evaluated the effects of topical application of melatonin on vertical bone augmentation in rat calvaria secluded spaces.
  
  
  METHODS
  In total, 12 male Fischer rats were used and two plastic caps were fixed in the calvarium. One plastic cap was filled with melatonin powder and the other was left empty.
  
  
  RESULTS
  Newly generated bone at bone defects and within the plastic caps was evaluated using micro-CT and histological sections. New bone regeneration within the plastic cap was increased significantly in the melatonin versus the control group.
  
  
  CONCLUSIONS
  Melatonin promoted vertical bone regeneration in rat calvaria in the secluded space within the plastic cap.
authors.affiliation: Department of Periodontology, Nihon University School of Dentistry, 1-8-13, Kanda Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan, satou.shuuichi@nihon-u.ac.jp.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Shino
authors.forename: Akira
authors.initials: A
authors.lastname: Hasuike
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Arai
authors.forename: Masaki
authors.initials: M
authors.lastname: Honda
authors.forename: Keitaro
authors.initials: K
authors.lastname: Isokawa
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D012886:Skull / Q000187:drug effects* / Q000502:physiology*
chemical_list: D008550:Melatonin