title: [Hyperglycaemia is associated with worse outcomes in Latin-American individuals with acute myocardial infarction].
abstract: BACKGROUND
  Alterations in glucose metabolism have been reported as risk and poor prognostic factors for acute myocardial infarction (AMI); however in Latin-American population this information is limited. Thus, an evaluation was performed on the association between glycaemic status and short- and long-term outcomes in patients with a first AMI.
  
  
  METHODS
  A multicentre, prospective, observational, cohort study was conducted in 8 hospitals from Colombia and Ecuador.
  
  
  RESULTS
  A total of 439 patients with confirmed AMI were included, of which 305 (69.5%) had prediabetes or type2 diabetes mellitus (DM2). Compared with normal glycaemia group, patients with known DM2 had greater risk of prolonged hospital stay (HR: 2.60, 95%CI: 1.38-4.92, P=.003), Killip class iii/iv (HR: 9.46, 95%CI: 2.20-40.62, P=.002), and in-hospital heart failure (HR: 10.76, 95%CI: 3.37-34.31, P<.001). Patients with prediabetes, new DM2, and known DM2 showed higher rates of major adverse cardiovascular events after 3years follow-up.
  
  
  CONCLUSIONS
  Glucose metabolism abnormalities have an important significance in the short- and long-term prognosis in Latin-American patients that survive a first AMI.
authors.affiliation: Fundación Oftalmológica de Santander-FOSCAL, Floridablanca, Colombia; Instituto de Investigaciones MASIRA, Facultad de Medicina, Universidad de Santander-UDES, Bucaramanga, Colombia; División de Endocrinología, Escuela de Medicina, Universidad de Santiago de Compostela, Santiago de Compostela, La Coruña, España.
authors.forename: Diego
authors.initials: D
authors.lastname: Gomez-Arbelaez
authors.affiliation: Universidad del Quindío, Hospital San Juan de Dios, Fundación Cardiomet-Cequin, Armenia, Colombia.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Sánchez-Vallejo
authors.affiliation: Departamento de Medicina Interna, Universidad Militar Nueva Granada, Bogotá, Colombia.
authors.forename: Maritza
authors.initials: M
authors.lastname: Perez
authors.affiliation: Instituto de Investigaciones MASIRA, Facultad de Medicina, Universidad de Santander-UDES, Bucaramanga, Colombia; Fundación Cardiovascular de Colombia-FCV , Floridablanca, Colombia.
authors.forename: Ronald Gerardo
authors.initials: RG
authors.lastname: Garcia
authors.affiliation: Fundación Cardiovascular de Colombia-FCV , Floridablanca, Colombia.
authors.forename: Jhon Freddy
authors.initials: JF
authors.lastname: Arguello
authors.affiliation: Servicio de Cardiología, Hospital Luis Vernaza, Guayaquil, Ecuador.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Peñaherrera
authors.affiliation: Servicio de Cardiología, Hospital Luis Vernaza, Guayaquil, Ecuador.
authors.forename: Yan Carlos
authors.initials: YC
authors.lastname: Duarte
authors.affiliation: Departamento de Medicina Interna, Universidad Libre, Cali, Colombia.
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Casanova
authors.affiliation: Unidad de Cuidados Intensivos, Clínica Jaller, Universidad Libre, Barranquilla, Colombia.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Accini
authors.affiliation: Centro Cardiovascular Santa Lucia IPS, Cartagena, Colombia.
authors.forename: Aristides
authors.initials: A
authors.lastname: Sotomayor
authors.affiliation: Fundación Oftalmológica de Santander-FOSCAL, Floridablanca, Colombia.
authors.forename: Paul Anthony
authors.initials: PA
authors.lastname: Camacho
authors.affiliation: Fundación Oftalmológica de Santander-FOSCAL, Floridablanca, Colombia; Instituto de Investigaciones MASIRA, Facultad de Medicina, Universidad de Santander-UDES, Bucaramanga, Colombia. Electronic address: jplopezj@gmail.com.
authors.forename: Patricio
authors.initials: P
authors.lastname: Lopez-Jaramillo
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003105:Colombia / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D004484:Ecuador / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000453:epidemiology; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000453:epidemiology; D011236:Prediabetic State / Q000150:complications* / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
keywords: Diabetes mellitus; Infarto de miocardio; Latin-America; Latinoamérica; Myocardial infarction; Prediabetes; Prognosis; Pronóstico