title: Intermediate Outcomes of Femoropopliteal Stenting in Women: 3-Year Results of the DURABILITY II Trial.
abstract: BACKGROUND
  This study investigated the effects of gender on the 3-year outcomes of the StuDy for EvalUating EndovasculaR TreAtments of Lesions in the Superficial Femoral Artery and Proximal Popliteal By usIng the Protege EverfLex NitInol STent System II (DURABILITY II) trial.
  
  
  METHODS
  A total of 287 patients enrolled in the DURABILITY II trial (prospective and nonrandomized trial) were stratified by gender and evaluated for primary, primary assisted, and secondary patency at 3 years. Clinical scores including changes in ankle-brachial index (ABI) and walking impairment questionnaire (WIQ) scores were evaluated.
  
  
  RESULTS
  Overall 190 male and 97 female patients were included for analysis. The 3-year primary, assisted primary, and secondary patency rates for women versus men were 62.5% vs. 58.8%, 68.5% vs. 64.9%, and 72.1% vs. 67.2%, respectively (P < 0.05). Although ABIs at presentation were similar between women versus men (0.64 vs. 0.65, P < 0.05), women had lower ABI scores at 3 years compared with men (0.85 vs. 0.92, P = 0.03). Women versus men had inferior walking distance scores at presentation (13.6 vs. 25.7, P < 0.001), scores were equalized by 2 years (51.6 vs. 60.8, P < 0.05); however, 3-year follow-up demonstrated less durable results for women versus men (37.3 vs. 58.8, P < 0.05). In addition, women had worse WIQ scores for pain, walking speed, and stair climbing. However, the relative change in scores between men and women were comparable, with both groups seeing similar improvements from baseline for these parameters.
  
  
  CONCLUSIONS
  Women continue to see clinical improvement after intervention, achieving comparable ABIs and walking distance to men at 2 years. These benefits are diminished at 3-year follow-up with women achieving lower absolute ABI and WIQ parameters compared with men, but improved overall compared with scores at presentation.
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Mount Sinai Hospital, New York, NY.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Han
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Mount Sinai Hospital, New York, NY.
authors.forename: Peter L
authors.initials: PL
authors.lastname: Faries
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Mount Sinai Hospital, New York, NY.
authors.forename: Christine
authors.initials: C
authors.lastname: Chung
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Mount Sinai Hospital, New York, NY.
authors.forename: Marvin V
authors.initials: MV
authors.lastname: Weaver
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Mount Sinai Hospital, New York, NY.
authors.forename: Rami O
authors.initials: RO
authors.lastname: Tadros
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Mount Sinai Hospital, New York, NY.
authors.forename: Windsor
authors.initials: W
authors.lastname: Ting
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Mount Sinai Hospital, New York, NY. Electronic address: ageliki.vouyouka@mountsinai.org.
authors.forename: Ageliki G
authors.initials: AG
authors.lastname: Vouyouka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000497:Alloys; D055109:Ankle Brachial Index; D019917:Blood Vessel Prosthesis Implantation; D057510:Endovascular Procedures; D005260:Female; D005263:Femoral Artery; D006801:Humans; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000601:surgery*; D011150:Popliteal Artery; D011446:Prospective Studies; D011788:Quality of Life; D012737:Sex Factors; D015607:Stents; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency; D016138:Walking
chemical_list: D000497:Alloys; C013616:nitinol