title: Serum Osteocalcin Is Associated with Inflammatory Factors in Metabolic Syndrome: A Population-Based Study in Chinese Males.
abstract: Osteocalcin (OCN) was potentially associated with inflammatory factors, so we explored the metabolic role in this association in general population. Our findings suggest that OCN was positively associated with IgG while inversely associated with C3, both of which were probably mediated by obesity. Moreover, serum OCN was inversely associated with hsCRP in men with impaired fasting glucose, hyperglycemia, or metabolic syndrome, while its association with IgE was significantly observed in men with a normal metabolic profile.
authors.affiliation: Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China ; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China ; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China ; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China ; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19014, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Liao
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China ; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China ; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Oncology, Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530031, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China ; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China ; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China ; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China ; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
authors.forename: Ziting
authors.initials: Z
authors.lastname: Yao
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China ; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China ; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
authors.forename: Xinggu
authors.initials: X
authors.lastname: Lin
authors.affiliation: Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China ; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China ; Department of Urology, First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan 453100, China.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Wu
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China ; Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.affiliation: Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China ; School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China ; General Practice School, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China ; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China ; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China ; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*
chemical_list: D003176:Complement C3; D007074:Immunoglobulin G; D015675:Osteocalcin; D007073:Immunoglobulin E; D002097:C-Reactive Protein