title: CTLA-4 and Autoimmunity: New Twists in the Tale.
abstract: CTLA-4 has long been associated with control of autoimmunity. A recent study by Sharpe and colleagues explores this relationship in a model that enables conditional deletion of CTLA-4 in adult mice, with some surprising new conclusions.
authors.affiliation: Institute for Immunity & Transplantation, University College London Division of Infection & Immunity, Royal Free Campus, London, NW3 2PF, UK. Electronic address: lucy.walker@ucl.ac.uk.
authors.forename: Lucy S K
authors.initials: LSK
authors.lastname: Walker
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D060908:CTLA-4 Antigen / Q000235:genetics*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D060908:CTLA-4 Antigen