title: 6(17)-Epoxylathyrane diterpenes from Euphorbia sogdiana Popov with cytotoxic activity.
abstract: Phytochemical analysis of Euphorbia sogdiana Popov, Euphorbiaceae, afforded the isolation of three new diterpenes based on the rare 6(17)-epoxylathyrane skeleton (1-3), along with a lathyrane (4), a myrsinane (5) and a tigliane (6) diterpenoids, previously isolated from Euphorbia aellenii. Their chemical structures were established through a combination of nuclear magnetic resonance spectroscopy and mass spectrometric methods. The epoxylathyranes 1-4 were tested to evaluate their cytotoxic activity against Jurkat T-leukemia and EJ-138 bladder cancer cells and their chemical analogy allowed to propose some structure activity relationships.
authors.affiliation: Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Yazdiniapour
authors.affiliation: Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: Ghannadian@gmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ghanadian
authors.affiliation: Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Zolfaghari
authors.affiliation: Dipartimento di Agraria, Università di Napoli Federico II, Portici, Napoli, Italy. Electronic address: lanzotti@unina.it.
authors.forename: Virginia
authors.initials: V
authors.lastname: Lanzotti
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C530347:lathyrane
keywords: 6(17)-Epoxylathyrane; Cytotoxic activity; Euphorbia sogdiana Popov; Euphorbiaceae; Lathyrane diterpenes