title: Cerebral small vessel disease and Alzheimer's disease.
abstract: Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger's disease, and cerebral microbleeds. CSVD is an important cerebral microvascular pathogenesis as it is the cause of 20% of strokes worldwide and the most common cause of cognitive impairment and dementia, including vascular dementia and Alzheimer's disease (AD). It has been well identified that CSVD contributes to the occurrence of AD. It seems that the treatment and prevention for cerebrovascular diseases with statins have such a role in the same function for AD. So far, there is no strong evidence-based medicine to support the idea, although increasing basic studies supported the fact that the treatment and prevention for cerebrovascular diseases will benefit AD. Furthermore, there is still lack of evidence in clinical application involved in specific drugs to benefit both AD and CSVD.
authors.affiliation: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, People's Republic of China.
authors.forename: Zhiyou
authors.initials: Z
authors.lastname: Cai
authors.affiliation: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, People's Republic of China.
authors.forename: Chuanling
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, People's Republic of China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Basic Research Center, Hubei University of Medicine, Shiyan, Hubei Province, People's Republic of China.
authors.forename: Hanjun
authors.initials: H
authors.lastname: Tu
authors.affiliation: Department of Neurosurgery, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, People's Republic of China.
authors.forename: Zhengang
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Anatomy, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Xiao
authors.affiliation: Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: Liang-Jun
authors.initials: LJ
authors.lastname: Yan
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology*; D001284:Atrophy; D001921:Brain / Q000473:pathology; D059345:Cerebral Small Vessel Diseases / Q000503:physiopathology*; D003072:Cognition Disorders / Q000503:physiopathology; D003704:Dementia / Q000503:physiopathology; D015140:Dementia, Vascular / Q000503:physiopathology; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics / Q000378:metabolism; D049292:Leukoaraiosis / Q000503:physiopathology; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D059409:Stroke, Lacunar / Q000503:physiopathology
chemical_list: D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human
keywords: cerebral microbleeds; cerebrovascular diseases; dementia; lacunar infarct; leukoaraiosis