title: Inflation and Bi-Axial Tensile Testing of Healthy Porcine Carotid Arteries.
abstract: Knowledge of the intrinsic material properties of healthy and diseased arterial tissue components is of great importance in diagnostics. This study describes an in vitro comparison of 13 porcine carotid arteries using inflation testing combined with functional ultrasound and bi-axial tensile testing. The measured tissue behavior was described using both a linear, but geometrically non-linear, one-parameter (neo-Hookean) model and a two-parameter non-linear (Demiray) model. The shear modulus estimated using the linear model resulted in good agreement between the ultrasound and tensile testing methods, GUS = 25 ± 5.7 kPa and GTT = 23 ± 5.4 kPa. No significant correspondence was observed for the non-linear model aUS = 1.0 ± 2.7 kPa vs. aTT = 17 ± 8.8 kPa, p ∼ 0); however, the exponential parameters were in correspondence (bUS = 12 ± 4.2 vs. bTT = 10 ± 1.7, p > 0.05). Estimation of more complex models in vivo is cumbersome considering the sensitivity of the model parameters to small changes in measurement data and the absence of intraluminal pressure data, endorsing the use of a simple, linear model in vivo.
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: Renate W
authors.initials: RW
authors.lastname: Boekhoven
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: Mathijs F J
authors.initials: MF
authors.lastname: Peters
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: Marcel C M
authors.initials: MC
authors.lastname: Rutten
authors.affiliation: Vascular Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
authors.forename: Marc R
authors.initials: MR
authors.lastname: van Sambeek
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: Frans N
authors.initials: FN
authors.lastname: van de Vosse
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. Electronic address: r.lopata@tue.nl.
authors.forename: Richard G P
authors.initials: RG
authors.lastname: Lopata
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000502:physiology*; D003198:Computer Simulation; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D008954:Models, Biological; D010363:Pattern Recognition, Automated / Q000379:methods*; D011312:Pressure; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013552:Swine; D013718:Tensile Strength / Q000502:physiology*; D014463:Ultrasonography / Q000379:methods
keywords: Bi-axial tensile testing; Carotid artery; Inflation testing; Ultrasound elastography