title: [Immunotherapy of uveal melanoma: vaccination against cancer. Multicenter adjuvant phase 3 vaccination study using dendritic cells laden with tumor RNA for large newly diagnosed uveal melanoma].
abstract: Uveal melanomas are the most common malignant tumors of the eye. With modern molecular biological diagnostic methods, such as chromosome 3 typing and gene expression analysis, these tumors can be categorized into highly aggressive (monosomy 3, class II) and less aggressive forms. This molecular biological stratification is primarily important for determining the risk of these tumors as no therapy is currently available that is able to prevent or delay metastases. A randomized study of patients with a poor prognosis (monosomy 3) is currently being carried out in order to determine whether a cancer vaccine prepared from autologous (patient's own) dendritic cells and uveal melanoma RNA can prevent or delay progression and further metastases of this extremely aggressive form of cancer. Inclusion in the uveal melanoma study, which hopes to provide a potential therapeutic option for patients, is only possible if patients are referred to an institution that is able to manufacture and provide this vaccination before the patient is operated on or treated with radiation. Untreated tumor material is necessary for producing the vaccine on an individualized patient basis.
authors.affiliation: Experimentelle Immuntherapie, Hautklinik, Universitätsklinikum Erlangen, Hartmannstr. 14, 90152, Erlangen, Deutschland. beatrice.schuler-thurner@uk-erlangen.de.
authors.forename: B
authors.initials: B
authors.lastname: Schuler-Thurner
authors.affiliation: Augenklinik, UK Tübingen, Tübingen, Deutschland.
authors.forename: K-U
authors.initials: KU
authors.lastname: Bartz-Schmidt
authors.affiliation: Augenklinik, UK Essen, Essen, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Bornfeld
authors.affiliation: Zentrum für Augenheilkunde, UK Köln, Köln, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Cursiefen
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, UK Hamburg-Eppendorf, Hamburg-Eppendorf, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Fuisting
authors.affiliation: Augenklinik, UK Lübeck, Lübeck, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Grisanti
authors.affiliation: Zentrum für Augenheilkunde, UK Köln, Köln, Deutschland.
authors.forename: L M
authors.initials: LM
authors.lastname: Heindl
authors.affiliation: Augenklinik, UK Erlangen, Erlangen, Deutschland.
authors.forename: L
authors.initials: L
authors.lastname: Holbach
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, UK Hamburg-Eppendorf, Hamburg-Eppendorf, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Keserü
authors.affiliation: Augenklinik, UK Erlangen, Erlangen, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Knorr
authors.affiliation: Zentrum für Augenheilkunde, UK Köln, Köln, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Koch
authors.affiliation: Augenklinik, UK Erlangen, Erlangen, Deutschland.
authors.forename: F
authors.initials: F
authors.lastname: Kruse
authors.affiliation: Augenklinik, UK Erlangen, Erlangen, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Meiller
authors.affiliation: Augenklinik, UK Essen, Essen, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Metz
authors.affiliation: Augenklinik, JMU Würzburg, Würzburg, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Meyer-ter-Vehn
authors.affiliation: Augenklinik, JMU Würzburg, Würzburg, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Much
authors.affiliation: Augenklinik, UK Lübeck, Lübeck, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Reinsberg
authors.affiliation: Experimentelle Immuntherapie, Hautklinik, Universitätsklinikum Erlangen, Hartmannstr. 14, 90152, Erlangen, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Schliep
authors.affiliation: Klinik für Augenheilkunde, UK des Saarlandes, Homburg, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Seitz
authors.affiliation: Experimentelle Immuntherapie, Hautklinik, Universitätsklinikum Erlangen, Hartmannstr. 14, 90152, Erlangen, Deutschland.
authors.forename: G
authors.initials: G
authors.lastname: Schuler
authors.affiliation: Augenklinik, UK Tübingen, Tübingen, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Süsskind
authors.affiliation: Klinik für Augenheilkunde, UK des Saarlandes, Homburg, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Viestenz
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, UK Hamburg-Eppendorf, Hamburg-Eppendorf, Deutschland.
authors.forename: L
authors.initials: L
authors.lastname: Wagenfeld
authors.affiliation: Institut für Humangenetik, Ophthalmologische Onkologie und Genetik, UK Essen, Essen, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Zeschnigk
mesh_terms: D000328:Adult; D000368:Aged; D019496:Cancer Vaccines / Q000627:therapeutic use*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D008875:Middle Aged; D012334:RNA, Neoplasm / Q000276:immunology; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*
chemical_list: D019496:Cancer Vaccines; D012334:RNA, Neoplasm
keywords: Cancer vaccination; Dendritic cells; Immunotherapy, cancer; Monosomy 3; Uveal melanoma