title: [Zinc signaling-mediated regulation of dentin and periodontal tissues].
abstract: An essential trace element zinc is required for variety of cellular functions and physiological responses, therefore, downregulation of zinc homeostasis cause serious problems in health, such as growth retardation and abnormal bone formation. Recent technical advances contributed to reveal that zinc ion regulated by zinc transporters acts as a signaling mediator, called zinc signaling that involves in mammalian physiology and pathogenesis. This review will address the current understanding of the roles of zinc signaling in regulation of dentin formation and periodontal tissues homeostasis.
authors.affiliation: Tokushima Bunri University, Faculty of Pharmaceutical Sciences, Molecular and Cellular Physiology, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fukada
authors.affiliation: Department of Pediatric Dentistry, Tsurumi University, School of Dental Medicine, Japan.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Idaira
authors.affiliation: Department of Oral Anatomy, Tsurumi University, School of Dental Medicine, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Shimoda
authors.affiliation: Department of Pediatric Dentistry, Tsurumi University, School of Dental Medicine, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Asada
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D027682:Cation Transport Proteins / Q000378:metabolism; D003804:Dentin / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D015398:Signal Transduction; D015032:Zinc / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D027682:Cation Transport Proteins; C017800:zinc-binding protein; D015032:Zinc