title: Neocollagenesis in Deep and Superficial Dermis by Combining Fractionated Q-Switched ND:YAG 1,064-nm With Topical Plant Stem Cell Extract and N-Acetyl Glucosamine: Open Case Series.
abstract: BACKGROUND
  As we enter a new age of increasing demand in novel cosmetic therapies, we are challenged to provide excellent results with minimal downtime and safety in all skin types. In this open case series we are studying the improvement in rhytides by combining a novel, FDA-approved, non-ablative fractionated Q-switched ND: YAG 1,064-nm laser that acts in the deep dermis, with a topical containing plant stem cell extract and N-acetyl glucosamine (NAG) that acts in the superficial dermis.
  
  
  METHODS
  Six healthy females (Skin types III - V) were selected for the study with mean average age of 56 years +/- 11 years. The rhytides on the face and neck were assessed using a comprehensive grading scale. Patients were then divided into two groups, one received only laser treatment with the fractionated QSW 1,064 nm laser and the other group received combined treatment with the laser and topical. Patients were assessed again at 4 and 8 weeks.
  
  
  RESULTS
  We observed an enhanced anti-aging effect of the laser in the patients with combined treatment.
  
  
  CONCLUSIONS
  Understanding the effect of this novel laser therapy on human stem cells and investigating the basis of its synergistic effect with plant stem cell extract and NAG will lead us to better understand stem cell activity. Non-ablative tissue regeneration is the next step in providing optimal anti-aging treatments.
authors.forename: Kavita
authors.initials: K
authors.lastname: Beri
authors.forename: Sandy S
authors.initials: SS
authors.lastname: Milgraum
mesh_terms: D000117:Acetylglucosamine / Q000008:administration & dosage*; D000368:Aged; D003094:Collagen / Q000096:biosynthesis; D003131:Combined Modality Therapy; D003357:Cosmetic Techniques; D020405:Dermis / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage*; D015595:Skin Aging; D013234:Stem Cells / Q000737:chemistry; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D003094:Collagen; D000117:Acetylglucosamine