title: [Ovarian failure: New treatments in perspective?].
abstract: The premature loss of ovarian function may have physical and psychological consequences. A better understanding of its mechanism is therefore needed. Because they are affecting the oocyte quality, the decline of the ovarian reserve and high maternal age are implicated in many defects leading to chromosomal defects, modifications of gene expression or alterations of the mitochondrial pattern of the oocyte. However, cellular therapies such as ovarian follicle activation or isolation of ovarian stem cells are promising treatments of ovarian failure.
authors.affiliation: Laboratoire de biologie de la reproduction, CHU de Rennes, 2, rue Henri-Le-Guillou, 35033 Rennes, France; Faculté de médecine, université Rennes 1, 35043 Rennes, France; Inserm, IRSET U1085, 263, avenue du Général-Leclerc, 35042 Rennes cedex, France. Electronic address: celia.ravel@chu-rennes.fr.
authors.forename: C
authors.initials: C
authors.lastname: Ravel
authors.affiliation: Laboratoire de biologie de la reproduction, CHU de Rennes, 2, rue Henri-Le-Guillou, 35033 Rennes, France; Faculté de médecine, université Rennes 1, 35043 Rennes, France.
authors.forename: N
authors.initials: N
authors.lastname: Kazdar
authors.affiliation: Service de gynécologie, CHU de Rennes, 2, rue Henri-Le-Guillou, 35033 Rennes, France.
authors.forename: J
authors.initials: J
authors.lastname: Leveque
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases; D005260:Female; D006801:Humans; D008423:Maternal Age; D009154:Mutation; D009865:Oocytes; D000072977:Oogonial Stem Cells; D006080:Ovarian Follicle; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000235:genetics / Q000628:therapy*; D027724:Reproductive Techniques, Assisted
keywords: Activation folliculaire; Cellules souches; Fertility; Fertilité; Follicle activation; Genetics; Génétique; Insuffisance ovarienne; Ovarian failure; Stem cells