title: Constellation Map: Downstream visualization and interpretation of gene set enrichment results.
abstract: Gene set enrichment analysis (GSEA) approaches are widely used to identify coordinately regulated genes associated with phenotypes of interest. Here, we present Constellation Map, a tool to visualize and interpret the results when enrichment analyses yield a long list of significantly enriched gene sets. Constellation Map identifies commonalities that explain the enrichment of multiple top-scoring gene sets and maps the relationships between them. Constellation Map can help investigators take full advantage of GSEA and facilitates the biological interpretation of enrichment results.
  
  
  BACKGROUND
  Constellation Map is freely available as a GenePattern module at http://www.genepattern.org.
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.|Bioinformatics Program, Boston University, Boston, MA, 02215, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
authors.forename: Felix
authors.initials: F
authors.lastname: Wu
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
authors.forename: Pablo
authors.initials: P
authors.lastname: Tamayo
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.|Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.|Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA, 02215, USA.
authors.forename: W Nicholas
authors.initials: WN
authors.lastname: Haining
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.|Bioinformatics Program, Boston University, Boston, MA, 02215, USA.
authors.forename: Jill P
authors.initials: JP
authors.lastname: Mesirov
keywords: GSEA; gene expression; gene set enrichment analysis; mutual information; pathway; signature; visualization