title: [Semaphorins as treatment targets for cartilage and bone damage caused by rheumatoid arthritis].
abstract: Semaphorins family consists of more than 20 proteins, categorized into 8 subclasses. Semaphorins play critical roles in neural development, immune response, and bone metabolism. Rheumatoid arthritis (RA) is a disease which shows abnormality in immunity and bone homeostasis. Therefore, semaphorins are suggested to be relevant to RA. Here, we described the role of semaphorins in bone metabolism and the association with semaphorins and RA which are found by basic and translational research.
authors.affiliation: Department of Respiratory Medicine, Allergy and Rheumatic Diseases,Osaka University Graduate School of Medicine, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: Department of Respiratory Medicine, Allergy and Rheumatic Diseases,Osaka University Graduate School of Medicine, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kumanogoh
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism; D001847:Bone Diseases / Q000276:immunology* / Q000378:metabolism; D002357:Cartilage Diseases / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D039961:Semaphorins / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D039961:Semaphorins