title: [Clinical implications of basic research in preeclampsia: immunological tolerance].
abstract: Preeclampsia is one of the main causes of maternal and perinatal mortality in the world; however, the pathophysiologic pathways haven't been clearly elucidated. It is thought to result from a breakdown of maternal tolerance to paternal antigens in placenta that start an immune response against the trophoblast inducing a defective placentation and a hipoxic/isquemic environment which in turn triggers a systemic inflamatory response. This review gives an overview of the mechanims involved in maternal tolerance, how these are disrupted in preeclampsia, and how they contribute to the inflamatory response.
authors.forename: Jorge
authors.initials: J
authors.lastname: Valencia-Ortega
authors.forename: Arturo
authors.initials: A
authors.lastname: Zárate
authors.forename: Renata
authors.initials: R
authors.lastname: Saucedo
authors.forename: Hernández-Valencia
authors.initials: HV
authors.lastname: Marcelino
authors.forename: José Gregorio
authors.initials: JG
authors.lastname: Cruz-Durán
authors.forename: Edgardo
authors.initials: E
authors.lastname: Puello-Tamara
authors.forename: Fabián
authors.initials: F
authors.lastname: Arechavaleta-Velasco
mesh_terms: D035843:Biomedical Research; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy