title: Metastatic saccrococcygeal chordoma.
abstract: We report a 46-year-old man who presented with a 2week history of worsening headaches and acute onset left sided hemiplegia. He had undergone a surgical resection of a sacral chordoma 13years prior, followed by adjuvant radiotherapy and chemotherapy. MRI revealed multiple enhancing lesions in the brain, and the two largest were resected. The histopathology was consistent with chordoma. Sacrococcygeal chordomas are locally invasive notochord-related sarcomas. They rarely metastasize to the brain, and only eight patients have been reported. While currently available adjuvant radiotherapy and systemic chemotherapeutic regimens can be implemented in the management of these rare patients, they have shown limited success. The newer strategies that are reported here have also been disappointing.
authors.affiliation: Division of Neurosurgery, University of British Columbia, Vancouver, Canada.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Fatehi Hassanabad
authors.affiliation: Division of Neurosurgery, University of Toronto, Canada.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mansouri
authors.affiliation: Division of Neurosurgery, University of Toronto, Canada.
authors.forename: Naif M
authors.initials: NM
authors.lastname: Alotaibi
authors.affiliation: Division of Pathology, University Health Network, Toronto, Canada.
authors.forename: Lili-Naz
authors.initials: LN
authors.lastname: Hazrati
authors.affiliation: Division of Neurosurgery, University of Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital, Toronto, Canada. Electronic address: mark.bernstein@uhn.ca.
authors.forename: Mark
authors.initials: M
authors.lastname: Bernstein
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D002817:Chordoma / Q000175:diagnosis* / Q000601:surgery; D003050:Coccyx / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D012447:Sacrum / Q000473:pathology* / Q000601:surgery; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000601:surgery
keywords: Brain metastases; Cerebral metastases; Sacrococcygeal chordomas