title: Targeting Endogenous Repair Pathways after AKI.
abstract: AKI remains a highly prevalent disease associated with poor short- and long-term outcomes and high costs. Although significant advances in our understanding of repair after AKI have been made over the last 5 years, this knowledge has not yet been translated into new AKI therapies. A consensus conference held by the Acute Dialysis Quality Initiative was convened in April of 2014 and reviewed new evidence on successful kidney repair to identify the most promising pathways that could be translated into new treatments. In this paper, we provide a summary of current knowledge regarding successful kidney repair and offer a framework for conceptualizing the therapeutic targeting that may facilitate this process. We outline gaps in knowledge and suggest a research agenda to more efficiently bring new discoveries regarding repair after AKI to the clinic.
authors.affiliation: Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; bhumphre@dom.wustl.edu.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Humphreys
authors.affiliation: Nephrology, Dialysis and Kidney Transplantation Unit, Department of Medical Sciences, University of Torino, Azienda Ospedaliera Città della Salute e della Scienza 'Molinette,' Turin, Italy;
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cantaluppi
authors.affiliation: Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia Health System, Charlottesville, Virginia;
authors.forename: Didier
authors.initials: D
authors.lastname: Portilla
authors.affiliation: Center for Critical Care Nephrology and Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania;
authors.forename: Kai
authors.initials: K
authors.lastname: Singbartl
authors.affiliation: Renal Division, Peking University First Hospital, Beijing, China; and.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia Health System, Charlottesville, Virginia;
authors.forename: Mitchell H
authors.initials: MH
authors.lastname: Rosner
authors.affiliation: Center for Critical Care Nephrology and Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania;
authors.forename: John A
authors.initials: JA
authors.lastname: Kellum
authors.affiliation: Department of Nephrology Dialysis and Transplantation, San Bortolo Hospital and the International Renal Research Institute, Vicenza, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D006801:Humans; D007668:Kidney / Q000502:physiology; D012038:Regeneration
keywords: CKD; acute renal failure; cell biology and structure; cell survival; interstitial fibrosis; stem cell