title: Drug Fever Induced by Piperacillin/Tazobactam in a Scoliosis Patient: A Case Report.
abstract: Drug fever is frequently underrecognized by clinicians despite its common occurrence. Fever induced by piperacillin/tazobactam has not been reported in scoliosis correction surgery.Drug fever caused by piperacillin/tazobactam in a scoliosis patient was described.A 36-year-old woman with adult scoliosis undergoing correction surgery was reported. She developed a fever after an intake of piperacillin/tazobactam for 3 days. Eosinophil count, erythrocyte sedimentation rate, and C-reactive proteins were increased in her blood examination. Thorough history, chest radiography, blood cultures, physical examination, and urinalysis revealed no evidences of fever. A drug fever is therefore considered. The fever lasted for 2 weeks and her body temperature come back to normal 4 days after piperacillin/tazobactam cessation.Fever could be caused by piperacillin/tazobactam. The drug fever's diagnosis is easily confounded by a co-occurring infection. Therefore, it is crucial for clinicians to doubt drugs as a reason when no other origin of fever could be identified in a patient.
authors.affiliation: From the Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (ZL, JS, QL); Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong (MTVC, WKKW); and State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China (WKKW).
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Shen
authors.forename: Qiyi
authors.initials: Q
authors.lastname: Li
authors.forename: Matthew Tak Vai
authors.initials: MTV
authors.lastname: Chan
authors.forename: William Ka Kei
authors.initials: WKK
authors.lastname: Wu
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D010397:Penicillanic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000009:adverse effects; D000077725:Piperacillin, Tazobactam Drug Combination; D011183:Postoperative Complications / Q000139:chemically induced* / Q000175:diagnosis; D012600:Scoliosis / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin