title: Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa.
abstract: Neonatal invasive disease due to Streptococcus agalactiae is life threatening and preventive strategies suitable for resource limited settings are urgently needed. Protective coverage of vaccine candidates based on capsular epitopes will relate to local epidemiology of S. agalactiae serotypes and successful management of critical infections depends on timely therapy with effective antibiotics. This is the first report on serotype distribution and antimicrobial susceptibility of S. agalactiae in pregnant women from a Central African region. Serotypes V, III, and Ib accounted for 88/109 (81%) serotypes and all isolates were susceptible to penicillin and clindamycin while 13% showed intermediate susceptibility to erythromycin.
authors.affiliation: Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.|Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.|Department of Pediatric Pneumology and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Belard
authors.affiliation: Clinic and Polyclinic for Pediatrics and Adolescent Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Nicole
authors.initials: N
authors.lastname: Toepfner
authors.affiliation: Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.|Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.|Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Mesküre
authors.initials: M
authors.lastname: Capan-Melser
authors.affiliation: Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.|Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.|Département de Parasitologie, Université des Sciences de la Santé, Libreville, Gabon.
authors.forename: Ghyslain
authors.initials: G
authors.lastname: Mombo-Ngoma
authors.affiliation: Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.|Ngounie Medical Research Centre, Fougamou, Gabon.
authors.forename: Rella
authors.initials: R
authors.lastname: Zoleko-Manego
authors.affiliation: Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.|Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Mirjam
authors.initials: M
authors.lastname: Groger
authors.affiliation: Ngounie Medical Research Centre, Fougamou, Gabon.
authors.forename: Pierre-Blaise
authors.initials: PB
authors.lastname: Matsiegui
authors.affiliation: Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.|Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.
authors.forename: Selidji T
authors.initials: ST
authors.lastname: Agnandji
authors.affiliation: Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.|Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.
authors.forename: Ayôla A
authors.initials: AA
authors.lastname: Adegnika
authors.affiliation: ISGlobal, Barcelona Ctr. Int. Health Res (CRESIB), Hospital Clínic- Universitat de Barcelona), Barcelona, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: González
authors.affiliation: Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.|Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Kremsner
authors.affiliation: ISGlobal, Barcelona Ctr. Int. Health Res (CRESIB), Hospital Clínic- Universitat de Barcelona), Barcelona, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Menendez
authors.affiliation: Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.|Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.|Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Ramharter
authors.affiliation: Clinic and Polyclinic for Pediatrics and Adolescent Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Berner
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D005260:Female; D005681:Gabon / Q000453:epidemiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D060885:Multiplex Polymerase Chain Reaction; D010406:Penicillins / Q000494:pharmacology; D011247:Pregnancy; D065288:Serogroup; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D014621:Vagina / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D010406:Penicillins; D002981:Clindamycin