title: Short Communication: HIV-1 Infection Suppresses Circulating Viral Restriction microRNAs.
abstract: MicroRNAs (miRNAs) participate in host innate immunity against HIV-1 infection. We examined the impact of HIV-1 infection on viral restriction miRNAs in plasma of HIV-1-infected subjects. HIV-1-infected subjects had significantly lower plasma levels of HIV-1 restriction miRNAs (miRs-29a, -29b, -125b, -223, -198, and -382) than control subjects. Further in vitro studies showed that HIV-1 infection of macrophages suppressed production of the extracellular miRs-29b, -125b, and -223. These data demonstrate the compelling evidence that HIV-1 infection impairs host innate immunity by inhibiting antiviral miRNAs, which provide a possible mechanism for HIV-1 persistence in the host.
authors.affiliation: 1 Center for Animal Experiment/ABSL-III Laboratory, State Key Laboratory of Virology, Wuhan University School of Basic Medical Sciences , Wuhan, China .|2 Department of Pathology and Laboratory Medicine, Temple University School of Medicine , Philadelphia, Pennsylvania.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: 1 Center for Animal Experiment/ABSL-III Laboratory, State Key Laboratory of Virology, Wuhan University School of Basic Medical Sciences , Wuhan, China .
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: 2 Department of Pathology and Laboratory Medicine, Temple University School of Medicine , Philadelphia, Pennsylvania.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: 3 School of Public Health, Guangxi Medical University , Nanning, China .
authors.forename: Hao
authors.initials: H
authors.lastname: Liang
authors.affiliation: 3 School of Public Health, Guangxi Medical University , Nanning, China .
authors.forename: Li
authors.initials: L
authors.lastname: Ye
authors.affiliation: 1 Center for Animal Experiment/ABSL-III Laboratory, State Key Laboratory of Virology, Wuhan University School of Basic Medical Sciences , Wuhan, China .
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: 3 School of Public Health, Guangxi Medical University , Nanning, China .
authors.forename: Bing-Yu
authors.initials: BY
authors.lastname: Liang
authors.affiliation: 2 Department of Pathology and Laboratory Medicine, Temple University School of Medicine , Philadelphia, Pennsylvania.
authors.forename: Jie-Liang
authors.initials: JL
authors.lastname: Li
authors.affiliation: 4 Wuhan Centers for Disease Prevention and Control , Wuhan, China .
authors.forename: Man-Qing
authors.initials: MQ
authors.lastname: Liu
authors.affiliation: 4 Wuhan Centers for Disease Prevention and Control , Wuhan, China .
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Peng
authors.affiliation: 4 Wuhan Centers for Disease Prevention and Control , Wuhan, China .
authors.forename: Dun-Jin
authors.initials: DJ
authors.lastname: Zhou
authors.affiliation: 5 Department of Infectious Diseases, Zhongnan Hospital of Wuhan University , Wuhan, China .
authors.forename: Xi-En
authors.initials: XE
authors.lastname: Gui
authors.affiliation: 1 Center for Animal Experiment/ABSL-III Laboratory, State Key Laboratory of Virology, Wuhan University School of Basic Medical Sciences , Wuhan, China .|2 Department of Pathology and Laboratory Medicine, Temple University School of Medicine , Philadelphia, Pennsylvania.
authors.forename: Wen-Zhe
authors.initials: WZ
authors.lastname: Ho
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion; D007108:Immune Tolerance; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged
chemical_list: D000998:Antiviral Agents; D035683:MicroRNAs