title: High-throughput sequencing insights into T-cell receptor repertoire diversity in aging.
abstract: Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.
authors.affiliation: Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. jgoronzy@stanford.edu.|Department of Medicine, VAPAHCS, Palo Alto, CA, 94306, USA. jgoronzy@stanford.edu.
authors.forename: Jörg J
authors.initials: JJ
authors.lastname: Goronzy
authors.affiliation: Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.|Department of Medicine, VAPAHCS, Palo Alto, CA, 94306, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Qi
authors.affiliation: Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, 94305, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Olshen
authors.affiliation: Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.|Department of Medicine, VAPAHCS, Palo Alto, CA, 94306, USA.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Weyand
mesh_terms: D000375:Aging / Q000235:genetics* / Q000276:immunology*; D000818:Animals; D002999:Clone Cells; D014644:Genetic Variation; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D011948:Receptors, Antigen, T-Cell