title: Membrane-drug interactions studied using model membrane systems.
abstract: The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins.
authors.affiliation: Flinders Centre for Nanoscale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Adelaide, Australia.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Knobloch
authors.affiliation: Flinders Centre for Nanoscale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Adelaide, Australia.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Suhendro
authors.affiliation: Flinders Centre for Nanoscale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Adelaide, Australia.
authors.forename: Julius L
authors.initials: JL
authors.lastname: Zieleniecki
authors.affiliation: Flinders Centre for Nanoscale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Adelaide, Australia.
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Shapter
authors.affiliation: Flinders Centre for Nanoscale Science and Technology, School of Chemical and Physical Sciences, Flinders University, Adelaide, Australia.
authors.forename: Ingo
authors.initials: I
authors.lastname: Köper
keywords: Drugs; Drug–membrane interaction; Model membranes; Review