title: Disturbance of time orientation, attention, and verbal memory in amnesic patients with confabulation.
abstract: Confabulation is often observed in amnesic patients after brain damage. However, evidence regarding the relationship between confabulation and other neuropsychological functions is scarce. In addition, previous studies have proposed two possibilities of the relationship between confabulation and false memory, in which patients with confabulation are likely to retrieve false memories, or confabulations are relatively independent of false memories. The present study investigated how confabulation is related to various cognitive functions, including orientation, attention, frontal lobe function, memory, and mental status, and to false memories, as assessed by the Deese-Roediger-Mcdermott (DRM) paradigm. Patients with organic amnesia participated, and confabulations were evaluated using the Confabulation Battery. Amnestic patients were classified into two groups: confabulating (CP) and nonconfabulating patients (NCP). The CP group was significantly impaired in time orientation, attention, and verbal memory, compared to the NCP group and age-matched healthy controls (HC). Results of the DRM paradigm revealed no significant difference in false memory retrieval induced by critical lures across CP, NCP, and HC groups. Confabulating responses in organic amnesia could be in part induced by disturbance of time consciousness and attention control in severe impairment of verbal memories, and confabulation and false memory could be modulated by different cognitive systems.
authors.affiliation: a Department of Clinical Psychology , Graduate School of Human Sciences, Osaka University , Osaka , Japan.
authors.forename: Honoka
authors.initials: H
authors.lastname: Shingaki
authors.affiliation: b Department of Cognitive and Behavioral Sciences , Graduate School of Human and Environmental Studies, Kyoto University , Kyoto , Japan.
authors.forename: Paeksoon
authors.initials: P
authors.lastname: Park
authors.affiliation: c Department of Psychiatry , Graduate School of Medicine, Kyoto University , Kyoto , Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Ueda
authors.affiliation: c Department of Psychiatry , Graduate School of Medicine, Kyoto University , Kyoto , Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Murai
authors.affiliation: b Department of Cognitive and Behavioral Sciences , Graduate School of Human and Environmental Studies, Kyoto University , Kyoto , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsukiura
mesh_terms: D000647:Amnesia / Q000145:classification / Q000150:complications / Q000503:physiopathology*; D001288:Attention / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000145:classification / Q000150:complications / Q000503:physiopathology*; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009949:Orientation / Q000502:physiology*; D012094:Repression, Psychology; D014706:Verbal Learning / Q000502:physiology
keywords: Confabulation; amnesia; attention; false memory; orientation