title: [Genome-wide association studies on the developmental dyslexia children].
abstract: OBJECTIVE
  To find out the potential polymorphisms of gene with developmental dyslexia children.
  
  
  METHODS
  From January 2010 to December 2013, 121 cases children with developmental dyslexia and 117 cases health children as the control were enrolled into the study. The potential polymorphisms of gene were found by case-control study strategies based on the Affymetrix Genome-Wide SNP 6. 0 microarray and pathway analysis.
  
  
  RESULTS
  Genotypes and allele frequencies of rs331142 and rs12495133 from DYX1C1 gene, rs11629841 and rs3743205 from ROBOl gene between cases and control groups were significantly different (P < 0. 05).
  
  
  CONCLUSIONS
  Polymorphism of rs331142 and rs12495133 from DYX1C1 gene, rs11629841 and rs3743205 from ROB01 gene may associate with developmental dyslexia children.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Wang
authors.forename: Guangcheng
authors.initials: G
authors.lastname: Cui
authors.forename: Ameng
authors.initials: A
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Deshui
authors.initials: D
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: Dai
authors.initials: D
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D004410:Dyslexia / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins