title: Histopathological and immunohistochemical characterization of spontaneous pituitary tumors in dwarfs derived from Wistar Hannover GALAS rats.
abstract: Histopathological and immunohistochemical characteristics of spontaneous pituitary adenomas found in dwarfs derived from Wistar Hanover GALAS are being described for the first time. The adenomas were seen in 5 males aged 48 weeks or older and in 11 females aged 34 weeks or older. Immunohistochemically, 13 cases without post-mortem changes could be evaluated; 4 Thyroid stimulating hormone (TSH)-containing adenomas, 2 TSH- and prolactin (PRL)-containing adenomas, 1 PRL-containing adenoma and 6 all-negative adenomas that did not react to any of the examined anti-hormone antibodies. The most common type were TSH-containing pituitary adenomas (a total of 6 cases; 46%) which occurred exclusively in females; the tumors consisted mainly of basophilic or amphophilic cells with bizarre nuclei and neoplastic cells and were positive for TSH in varying degrees. The TSH-containing pituitary adenomas, a characteristic of this mutant rat, could be induced by genetically-controlled hypothyroidism in dwarf rats, with higher sensitivity to possible disturbance of the pituitary-thyroid axis in females.
authors.affiliation: Pathology Department, Kashima Laboratory, Nonclinical Research Center, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan. Electronic address: moonlightdance_pineappleromance@yahoo.co.jp.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kokoshima
authors.affiliation: Pathology Department, Kashima Laboratory, Nonclinical Research Center, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan. Electronic address: yamada.naoaki@mn.medience.co.jp.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yamada
authors.affiliation: Pathology Department, Kashima Laboratory, Nonclinical Research Center, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan. Electronic address: Doi.Takuya@mx.medience.co.jp.
authors.forename: Takuya
authors.initials: T
authors.lastname: Doi
authors.affiliation: Pathology Department, Kashima Laboratory, Nonclinical Research Center, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan. Electronic address: Tsuchitani.Minoru@mp.medience.co.jp.
authors.forename: Minoru
authors.initials: M
authors.lastname: Tsuchitani
authors.affiliation: Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Rinkuu Ourai Kita, Izumisano, Osaka 598-8531, Japan. Electronic address: yamate@vet.osakafu-u.ac.jp.
authors.forename: Jyoji
authors.initials: J
authors.lastname: Yamate
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D004392:Dwarfism / Q000378:metabolism / Q000473:pathology*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology*; D011388:Prolactin / Q000378:metabolism; D011919:Rats, Inbred Strains; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone
keywords: Adenoma; Dwarfism; Hypothyroidism; Pituitary; Rat