title: The Effect of Risk Factors on the Levels of Chemical Elements in the Tibial Plateau of Patients with Osteoarthritis following Knee Surgery.
abstract: The aim of this study was to evaluate the aforementioned chemical elements in tibial plateau samples obtained during knee arthroplasty. The gender-specific analysis of chemical element levels in the bone samples revealed that there were statistically significant differences in the concentration of Pb and Se/Pb ratio. The contents of elements in the tibial plateau in the patients with osteoarthritis (OA) can be arranged in the following descending order: F(-) > K > Zn > Fe > Sr > Pb > Mn > Se > Cd > THg. We observed statistical significant effects of environmental factors including smoking, seafood diet, and geographical distribution on the levels of the elements in tibial bone. Significant positive correlation coefficients were found for the relationships K-Cd, Zn-Sr, Zn-F(-), THg-Pb, Pb-Cd, Se-Se/Pb, Se-Se/Cd, Se/Pb-Se/Cd, Pb-Cd/Ca, Cd-Cd/Ca, and F(-)-F(-)/Ca·1000. Significant negative correlations were found for the relationships THg-Se/Pb, Pb-Se/Pb, Cd-Se/Pb, K-Se/Cd, Pb-Se/Cd, Cd-Se/Cd, THg-Se/THg, Pb-Se/THg, Se-Pb/Cd, Zn-Cd/Ca, and Se/Cd-Cd/Ca. The results reported here may provide a basis for establishing reference values for the tibial plateau in patients with OA who had undergone knee replacement surgery. The concentrations of elements in the bone with OA were determined by age, presence of implants, smoking, fish and seafood diet, and sport activity.
authors.affiliation: Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Lanocha-Arendarczyk
authors.affiliation: Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Danuta Izabela
authors.initials: DI
authors.lastname: Kosik-Bogacka
authors.affiliation: Department of Chemical Hazards and Genetic Toxicology, Institute of Occupational Medicine and Environmental Health, Koscielna 13, 71-200 Sosnowiec, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Prokopowicz
authors.affiliation: Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Kalisinska
authors.affiliation: Chair and Clinic of Orthopaedics and Traumatology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Sokolowski
authors.affiliation: Chair and Clinic of Orthopaedics and Traumatology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Karaczun
authors.affiliation: Chair and Clinic of Orthopaedics and Traumatology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Zietek
authors.affiliation: Department of Ecology, Environmental Management and Protection, Slowackiego 17, 71-434 Szczecin, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Podlasińska
authors.affiliation: Department of Animal Reproduction Biotechnology and Environmental Hygiene, West Pomeranian University of Technology, Doktora Judyma 6, 71-466 Szczecin, Poland.
authors.forename: Bogumila
authors.initials: B
authors.lastname: Pilarczyk
authors.affiliation: Department of Animal Reproduction Biotechnology and Environmental Hygiene, West Pomeranian University of Technology, Doktora Judyma 6, 71-466 Szczecin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Tomza-Marciniak
authors.affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Irena
authors.initials: I
authors.lastname: Baranowska-Bosiacka
authors.affiliation: Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460 Szczecin, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Gutowska
authors.affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Chlubek
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D019645:Arthroplasty, Replacement, Knee; D002104:Cadmium / Q000302:isolation & purification / Q000633:toxicity; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D007854:Lead / Q000302:isolation & purification / Q000633:toxicity; D008297:Male; D008628:Mercury / Q000302:isolation & purification / Q000633:toxicity; D008875:Middle Aged; D010003:Osteoarthritis / Q000139:chemically induced / Q000209:etiology / Q000473:pathology; D012307:Risk Factors; D013977:Tibia / Q000737:chemistry* / Q000187:drug effects / Q000473:pathology; D014131:Trace Elements / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D014131:Trace Elements; D014874:Water Pollutants, Chemical; D002104:Cadmium; D007854:Lead; D008628:Mercury