title: Screening for coronary artery disease in asymptomatic individuals: Why and how?
abstract: Cardiovascular disease is still the main cause of death in the world, and coronary artery disease is the largest contributor. Screening asymptomatic individuals for coronary artery disease in view of preventive treatment is therefore of crucial interest. Apart from established risk scores based on traditional risk factors such as the Framingham or SCORE risk scores, new biomarkers and imaging methods have emerged (high-sensitivity C-reactive protein, lipoprotein-associated phospholipase A2 and secretory phospholipase A2, coronary artery calcium score, carotid intima-media thickness and ankle-brachial index). Their added value on top of the classic risk scores varies considerably and the most convincing evidence exists for coronary artery calcium score in intermediate-risk asymptomatic individuals.
authors.affiliation: Département hospitalo-universitaire fibrose, inflammation, remodelage (FIRE), French Alliance for Cardiovascular clinical Trials (FACT) and F-CRIN network, université Paris-Diderot, Sorbonne Paris Cité, Paris, France; Hôpital Bichat and hôpital Avicenne, Assistance publique-Hôpitaux de Paris, hôpitaux universitaires Paris Nord Val-de-Seine, Paris, France; Inserm U-1148, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Degrell
authors.affiliation: Département hospitalo-universitaire fibrose, inflammation, remodelage (FIRE), French Alliance for Cardiovascular clinical Trials (FACT) and F-CRIN network, université Paris-Diderot, Sorbonne Paris Cité, Paris, France; Hôpital Bichat and hôpital Avicenne, Assistance publique-Hôpitaux de Paris, hôpitaux universitaires Paris Nord Val-de-Seine, Paris, France; Inserm U-1148, Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Sorbets
authors.affiliation: Département hospitalo-universitaire fibrose, inflammation, remodelage (FIRE), French Alliance for Cardiovascular clinical Trials (FACT) and F-CRIN network, université Paris-Diderot, Sorbonne Paris Cité, Paris, France; Hôpital Bichat and hôpital Avicenne, Assistance publique-Hôpitaux de Paris, hôpitaux universitaires Paris Nord Val-de-Seine, Paris, France; Inserm U-1148, Paris, France.
authors.forename: Laurent J
authors.initials: LJ
authors.lastname: Feldman
authors.affiliation: Département hospitalo-universitaire fibrose, inflammation, remodelage (FIRE), French Alliance for Cardiovascular clinical Trials (FACT) and F-CRIN network, université Paris-Diderot, Sorbonne Paris Cité, Paris, France; Hôpital Bichat and hôpital Avicenne, Assistance publique-Hôpitaux de Paris, hôpitaux universitaires Paris Nord Val-de-Seine, Paris, France; Inserm U-1148, Paris, France; National Heart and Lung Institute, Royal Brompton Hospital, London, United Kingdom.
authors.forename: Philippe Gabriel
authors.initials: PG
authors.lastname: Steg
authors.affiliation: Département hospitalo-universitaire fibrose, inflammation, remodelage (FIRE), French Alliance for Cardiovascular clinical Trials (FACT) and F-CRIN network, université Paris-Diderot, Sorbonne Paris Cité, Paris, France; Hôpital Bichat and hôpital Avicenne, Assistance publique-Hôpitaux de Paris, hôpitaux universitaires Paris Nord Val-de-Seine, Paris, France; Inserm U-1148, Paris, France. Electronic address: gregory.ducrocq@bch.aphp.fr.
authors.forename: Gregory
authors.initials: G
authors.lastname: Ducrocq
mesh_terms: D058070:Asymptomatic Diseases / Q000453:epidemiology*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D014943:Global Health; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D009017:Morbidity / Q000639:trends; D012307:Risk Factors
keywords: Cardiovascular risk; Coronary artery calcium score; Coronary artery disease; Dépistage; Maladie coronaire; Prevention; Prévention; Risque cardiovasculaire; Score calcique; Screening