title: [INFLUENCE OF 29-40 AND 65-76 MCP-1 FRAGMENTS ON MYOCARDIUM MORPHOLOGY IN RATS AFTER T9CTHFMIA-R'FPFRFTTON].
abstract: Monocyte chemotactic protein-1 (MCP-1) is a chemokine that stimulates monocytes and macrophage migration into the sites of acute of chronic inflammation. Our study shows morphological changes in ischemic myocardium followed by the administration of two synthetic structural fragments of MCP-1 that are monocyte/macrophage migration inductor peptide IX and peptide X an inhibitor. Results show that peptides can change time points of the inflammatory response in myocardium. Peptide IX administration leads to increased and accelerated inflammatory response, i. e. attracts an additional number of monocytes and macrophages into the inflammatory focus. The introduction of the peptide X observed prolonged inflammatory process with the overall gain signs of myocardial damage.
authors.forename: M R
authors.initials: MR
authors.lastname: Akhmetshina
authors.forename: A B
authors.initials: AB
authors.lastname: Berdalin
authors.forename: M P
authors.initials: MP
authors.lastname: Morozova
authors.forename: S V
authors.initials: SV
authors.lastname: Buravkov
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Bespalova
authors.forename: M V
authors.initials: MV
authors.lastname: Sidorova
authors.forename: T I
authors.initials: TI
authors.lastname: Aref'eva
authors.forename: T L
authors.initials: TL
authors.lastname: Krasnikova
authors.forename: S A
authors.initials: SA
authors.lastname: Gavrilova
mesh_terms: D000818:Animals; D018932:Chemokine CCL2 / Q000494:pharmacology / Q000627:therapeutic use*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D009000:Monocytes / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
chemical_list: D018932:Chemokine CCL2; D010446:Peptide Fragments