title: Does the time interval between hysteroscopic polypectomy and start of in vitro fertilization affect outcomes?
abstract: OBJECTIVE
  To investigate whether the time interval between hysteroscopic polypectomy and the start of IVF-ET cycles affect IVF cycle outcomes.
  
  
  METHODS
  Retrospective cohort.
  
  
  METHODS
  Academic center.
  
  
  METHODS
  All patients diagnosed with endometrial polyps undergoing hysteroscopic polypectomy before fresh IVF-ET.
  
  
  METHODS
  Hysteroscopic polypectomy.
  
  
  METHODS
  Patients were divided into three groups based on the time interval between hysteroscopic polypectomy and the start of a fresh IVF-ET cycle. Group 1 consisted of patients who underwent IVF-ET after their next menses, group 2 after two or three menstrual cycles, and group 3 after more than three menstrual cycles. Demographics, baseline IVF characteristics, controlled ovarian stimulation response, and pregnancy outcomes after ET were compared among the groups.
  
  
  RESULTS
  A total of 487 patients met inclusion criteria: 241 in group 1 (49.5%), 172 in group 2 (35.3%), and 74 in group 3 (15.2%). There were no differences in the baseline characteristics of the three groups. Ovarian stimulation outcomes, specifically total stimulation days, total gonadotropins administered, and number of oocytes retrieved, were similar between groups. There were no differences in the mean number of embryos transferred. The overall pregnancy outcomes were similar for groups 1, 2, and 3: implantation rate (42.4%, 41.2%, and 42.1%, respectively), clinical pregnancy rate (48.5%, 48.3%, and 48.6%), spontaneous miscarriage rate (4.56%, 4.65%, and 4.05%), and live birth rate (44.0, 43.6%, and 44.6%).
  
  
  CONCLUSIONS
  Because waiting for two or more menstrual cycles after hysteroscopic polypectomy does not necessarily yield superior outcomes, patients can undergo ovarian stimulation after their next menses without affecting IVF-ET outcomes.
authors.affiliation: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
authors.forename: Nigel
authors.initials: N
authors.lastname: Pereira
authors.affiliation: Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York.
authors.forename: Selma
authors.initials: S
authors.lastname: Amrane
authors.affiliation: Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York.
authors.forename: Jaclyn L
authors.initials: JL
authors.lastname: Estes
authors.affiliation: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
authors.forename: Jovana P
authors.initials: JP
authors.lastname: Lekovich
authors.affiliation: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
authors.forename: Rony T
authors.initials: RT
authors.lastname: Elias
authors.affiliation: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.
authors.forename: Pak H
authors.initials: PH
authors.lastname: Chung
authors.affiliation: Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York. Electronic address: zrosenw@med.cornell.edu.
authors.forename: Zev
authors.initials: Z
authors.lastname: Rosenwaks
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000046:Academic Medical Centers; D000328:Adult; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005298:Fertility; D005300:Fertility Agents, Female / Q000008:administration & dosage; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D015907:Hysteroscopy / Q000009:adverse effects; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D008597:Menstrual Cycle; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011127:Polyps / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013997:Time Factors; D061665:Time-to-Treatment; D016896:Treatment Outcome; D014591:Uterine Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*
chemical_list: D005300:Fertility Agents, Female
keywords: Endometrial polyps; hysteroscopy; in vitro fertilization; polypectomy; timing