title: Optimized Diagnostic Assays Based on Redox Tagged Bioreceptive Interfaces.
abstract: Among the numerous label free electronic biomarker assay methodologies now available, impedance based electrochemical capacitance spectroscopy (ECS), based upon mapping the perturbations in interfacial charging of redox elements incorporated into a biologically receptive interface, has recently been shown to be a convenient and highly sensitive mode of transduction and one which, additionally, requires no predoping of analytical solution. We present, herein, a data acquisition and analysis methodology based on frequency resolved immittance function analysis. Ultimately, this enables both a maximization of assay sensitivity and a reduction in assay acquisition time by an order of magnitude.
authors.affiliation: Institute of Chemistry, Physical Chemistry Department, Nanobionics group, Univ. Estadual Paulista (São Paulo State University, UNESP) , CP 355, 14800-900, Araraquara, São Paulo, Brazil.
authors.forename: Flavio C
authors.initials: FC
authors.lastname: Bedatty Fernandes
authors.affiliation: Department of Chemistry, University of Oxford , South Parks Road, Oxford, OX1 3QZ, United Kingdom.
authors.forename: Amol V
authors.initials: AV
authors.lastname: Patil
authors.affiliation: Institute of Chemistry, Physical Chemistry Department, Nanobionics group, Univ. Estadual Paulista (São Paulo State University, UNESP) , CP 355, 14800-900, Araraquara, São Paulo, Brazil.
authors.forename: Paulo R
authors.initials: PR
authors.lastname: Bueno
authors.affiliation: Department of Chemistry, University of Oxford , South Parks Road, Oxford, OX1 3QZ, United Kingdom.
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Davis
mesh_terms: D015415:Biomarkers / Q000032:analysis; D055664:Electrochemical Techniques; D004566:Electrodes; D010084:Oxidation-Reduction; D055672:Static Electricity
chemical_list: D015415:Biomarkers