title: Genetic susceptibility to autoimmune thyroid diseases in a Chinese Han population: Role of vitamin D receptor gene polymorphisms.
abstract: OBJECTIVE
  Previous studies have found that some immune-related genes were associated with autoimmune thyroid diseases (AITDs). A couple of studies have explored the association between vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene polymorphisms and susceptibility to AITDs in different populations and found conflicting results. This case-control study was designed to evaluate the role of polymorphisms of VDR gene in the predisposition of AITDs in a Chinese Han population.
  
  
  METHODS
  A total of 417 patients with Graves' disease (GD), 250 patients with Hashimoto's thyroiditis (HT) and 301 healthy subjects were enrolled. The Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform was applied to detect four SNPs (rs1544410, rs2228570, rs731236 and rs7975232) in the VDR gene.
  
  
  RESULTS
  In the rs7975232 allele A frequency showed a significant increase in GD patients (30.34% vs. 25.42% in controls; P=0.041, OR=1.278, 95%CI=1.010-1.617). However, no relationship was found between clinical phenotypes and the four SNPs.
  
  
  CONCLUSIONS
  This result suggests that the VDR gene may be one susceptibility gene which contributes to the risk of GD.
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, 1508, Longhang Road, Shanghai 201508, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Meng
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, 1508, Longhang Road, Shanghai 201508, China.
authors.forename: Shuang-tao
authors.initials: ST
authors.lastname: He
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, 1508, Longhang Road, Shanghai 201508, China.
authors.forename: Wen-juan
authors.initials: WJ
authors.lastname: Jiang
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, 1508, Longhang Road, Shanghai 201508, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, 1508, Longhang Road, Shanghai 201508, China.
authors.forename: Dan-feng
authors.initials: DF
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, 1508, Longhang Road, Shanghai 201508, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, 1508, Longhang Road, Shanghai 201508, China.
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Shi
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, 1508, Longhang Road, Shanghai 201508, China. Electronic address: zhangjinan@hotmail.com.
authors.forename: Jin-an
authors.initials: JA
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006111:Graves Disease / Q000235:genetics*; D006239:Haplotypes; D050031:Hashimoto Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human
keywords: Autoimmune thyroid disease (AITD); Graves’ disease (GD); Hashimoto's thyroiditis (HT); Maladie de Basedow (GD); Maladies thyroïdiennes auto-immunes (MAIT); Polymorphisme de nucléotide unique (SNP); Récepteur à la vitamine D (VDR); Single nucleotide polymorphism (SNP); Thyroïdite de Hashimoto (HT); Vitamin D receptor (VDR)