title: The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity.
abstract: OBJECTIVE
  To evaluate the effects of a rose hip powder (Hyben Vital(®)) made from seeds and shells on cell senescence, skin wrinkling, and aging.
  
  
  METHODS
  A total of 34 healthy subjects, aged 35-65 years, with wrinkles on the face (crow's-feet) were subjected to a randomized and double-blinded clinical study of the effects of the rose hip powder, as compared to astaxanthin, a well-known remedy against wrinkles. During the 8-week study, half of the participants ingested the standardized rose hip product, while the other half ingested astaxanthin. Objective measurements of facial wrinkles, skin moisture, and elasticity were made by using Visioscan, Corneometer, and Cutometer at the beginning of the study, after 4 weeks, and after 8 weeks. Evaluation of participant satisfaction of both supplements was assessed using questionnaires. In addition, the effect of the rose hip preparation on cell longevity was measured in terms of leakage of hemoglobin through red cell membranes (hemolytic index) in blood samples kept in a blood bank for 5 weeks. Significance of all values was attained with P≤0.05.
  
  
  RESULTS
  In the double-blinded study, the rose hip group showed statistically significant improvements in crow's-feet wrinkles (P<0.05), skin moisture (P<0.05), and elasticity (P<0.05) after 8 weeks of treatment. A similar improvement was observed for astaxanthin, with P-values 0.05, 0.001, and 0.05. Likewise, both groups expressed equal satisfaction with the results obtained in their self-assessment. The rose hip powder further resulted in increased cell longevity of erythrocyte cells during storage for 5 weeks in a blood bank.
  
  
  CONCLUSIONS
  Results suggest that intake of the standardized rose hip powder (Hyben Vital(®)) improves aging-induced skin conditions. The apparent stabilizing effects of the rose hip product on cell membranes of stored erythrocyte cells observed in this study may contribute to improve the cell longevity and obstructing skin aging.
authors.affiliation: School of Antiaging and Regenerative Medicine, Mae Fah University, Bangkok, Thailand ; Department of Anti-aging and Regenerative Medicine, Mae Fah University, Bangkok, Thailand.
authors.forename: L
authors.initials: L
authors.lastname: Phetcharat
authors.affiliation: School of Antiaging and Regenerative Medicine, Mae Fah University, Bangkok, Thailand ; Department of Anti-aging and Regenerative Medicine, Mae Fah University, Bangkok, Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Wongsuphasawat
authors.affiliation: Institute for Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Winther
mesh_terms: D000328:Adult; D000368:Aged; D016922:Cellular Senescence / Q000187:drug effects; D004311:Double-Blind Method; D004548:Elasticity / Q000187:drug effects; D005145:Face; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D035261:Plant Components, Aerial; D027826:Rosa; D015595:Skin Aging / Q000187:drug effects*; D014867:Water; D024341:Xanthophylls / Q000627:therapeutic use
chemical_list: D006454:Hemoglobins; D024341:Xanthophylls; D014867:Water; C005948:astaxanthine
keywords: aging skin; cell longevity; elasticity; moisture; rose hip seed and shell powder; wrinkles