title: Effects of repeated quetiapine treatment on conditioned avoidance responding in rats.
abstract: The present study characterized the behavioral mechanisms of avoidance-disruptive effect of quetiapine in the conditioned avoidance response test under two behavioral testing (2 warning signals vs. 1 warning signal) and two drug administration conditions (subcutaneous vs. intravenous). In Experiments 1 and 2, well-trained adult male Sprague-Dawley rats were tested under the subcutaneous (s.c.) quetiapine treatment (5.0, 15.0, 25.0, 50.0mg/kg) for 7 days in a novel procedure consisting of two conditioned stimuli (CS) (white noise serving as CS1 and pure tone as CS2). Only the highest dose (50.0mg/kg) produced a persistent suppression of the avoidance response without impairing the escape response. The magnitude of suppression of the CS1 avoidance was similar to that of CS2 avoidance. No significant group difference was found in the quetiapine (15.0mg/kg, s.c.) challenge test, indicating a lack of a long-term quetiapine effect. In Experiment 3, well-trained rats were tested under the intravenous (i.v.) quetiapine treatment (3.0, 9.0, 15.0mg/kg) for 5 days and challenged with quetiapine (6.0mg/kg, i.v. followed by 9.0mg/kg, s.c.). Only the white noise was used as the CS. Similar to what was being observed in Experiments 1 and 2, intravenously administered quetiapine dose-dependently suppressed avoidance responding during the drug test days, but did not alter drug sensitivity in the challenge days. Thus, quetiapine does not appear to show a preferential inhibition of the avoidance response to a less salient stimulus; and prior quetiapine treatment (s.c. and i.v.) does not cause a sensitization or tolerance to quetiapine.
authors.affiliation: Key Laboratory of Cognition and Personality (Southwest University), Ministry of Education, China; Faculty of Psychology, Southwest University, Chongqing, China; Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Graduate School of Chinese Academy of Sciences, Beijing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
authors.forename: Natashia
authors.initials: N
authors.lastname: Swalve
authors.affiliation: Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
authors.forename: Collin
authors.initials: C
authors.lastname: Davis
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Electronic address: suin@psych.ac.cn.
authors.forename: Nan
authors.initials: N
authors.lastname: Sui
authors.affiliation: Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA. Electronic address: mli2@unl.edu.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D009042:Motivation / Q000187:drug effects; D000069348:Quetiapine Fumarate / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000069348:Quetiapine Fumarate
keywords: CS1 and CS2; Conditioned avoidance response; Quetiapine; Sensitization; Tolerance