title: Malignant sublingual gland tumors: demographics, prognostic factors, and treatment outcomes.
abstract: OBJECTIVE
  To determine the demographic characteristics, prognostic factors, and optimal treatment modalities of patients diagnosed with malignant primary tumors of the sublingual gland.
  
  
  METHODS
  The Surveillance, Epidemiology, and End Results (SEER) registry contains 210 patients diagnosed with sublingual gland tumors in the SEER database. Kaplan-Meier and multivariate Cox regression analysis were performed on age, sex, race, histologic subtype, stage, and treatment modality.
  
  
  RESULTS
  Kaplan-Meier analysis found an overall survival and disease-specific survival at 5 years of 69% and 83%, respectively. Multivariate analysis demonstrated that age, sex, stage, and surgery were predictors of overall survival, whereas stage was a predictor of disease-specific survival.
  
  
  CONCLUSIONS
  Here we report, to our knowledge, the largest study to date investigating demographic characteristics, prognostic factors, and treatment modalities of patients diagnosed with primary malignant tumors of the sublingual gland. Increased age and stage correlated with decreased survival, whereas female gender and surgical therapy correlated with increased survival in the overall population. Radiation therapy for patients diagnosed with adenoid cystic carcinoma in the sublingual gland was correlated with increased survival.
authors.affiliation: Dental Student, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lee
authors.affiliation: Dental Student, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Tong
authors.affiliation: Master's Student, Department of Statistics, UCLA, Los Angeles, CA, USA.
authors.forename: Riki
authors.initials: R
authors.lastname: Patel
authors.affiliation: Undergraduate Student, Department of Life Sciences, UCLA, Los Angeles, CA, USA.
authors.forename: Nihal
authors.initials: N
authors.lastname: Satyadev
authors.affiliation: Associate Professor, Department of Oral & Maxillofacial Pathology, UCLA School of Dentistry, Los Angeles, CA, USA. Electronic address: Rchristensen@dentistry.ucla.edu.
authors.forename: Russell E
authors.initials: RE
authors.lastname: Christensen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003710:Demography; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018426:SEER Program; D012468:Salivary Gland Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D013361:Sublingual Gland / Q000473:pathology*; D014481:United States / Q000453:epidemiology