title: Short communication: Camel milk ameliorates inflammatory responses and oxidative stress and downregulates mitogen-activated protein kinase signaling pathways in lipopolysaccharide-induced acute respiratory distress syndrome in rats.
abstract: Acute respiratory distress syndrome (ARDS) is a complex syndrome disorder with high mortality rate. Camel milk (CM) contains antiinflammatory and antioxidant properties and protects against numerous diseases. This study aimed to demonstrate the function of CM in lipopolysaccharide (LPS)-induced ARDS in rats. Camel milk reduced the lung wet:dry weight ratio and significantly reduced LPS-induced increases in neutrophil infiltration, interstitial and intra-alveolar edema, thickness of the alveolar wall, and lung injury scores of lung tissues. It also had antiinflammatory and antioxidant effects on LPS-induced ARDS. After LPS stimulation, the levels of proinflammatory cytokines (tumor necrosis factor-α, IL-10, and IL-1β) in serum and oxidative stress markers (malondialdehyde, myeloperoxidase, and total antioxidant capacity) in lung tissue were notably attenuated by CM. Camel milk also downregulated mitogen-activated protein kinase signaling pathways. Given these results, CM is a potential complementary food for ARDS treatment.
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, Shandong Province, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Zhu
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, Shandong Province, China.
authors.forename: Gui-Qing
authors.initials: GQ
authors.lastname: Kong
authors.affiliation: Department of Intensive Care Unit, Hulunbeier People's Hospital, Hulunbeier, 021000, Inner Mongolia Autonomous Region, China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Ma
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, Shandong Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, Shandong Province, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, Shandong Province, China.
authors.forename: Li-Peng
authors.initials: LP
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, Shandong Province, China.
authors.forename: Zhen-Yi
authors.initials: ZY
authors.lastname: Peng
authors.affiliation: Department of Biotechnology, Binzhou Medical University, Yantai, 264003, Shandong Province, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: Department of Cell Biology, Binzhou Medical University, Yantai, 264003, Shandong Province, China. Electronic address: liuxiangyong81@gmail.com.
authors.forename: Xiang-Yong
authors.initials: XY
authors.lastname: Liu
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, Shandong Province, China. Electronic address: hxicuwxz@163.com.
authors.forename: Xiao-Zhi
authors.initials: XZ
authors.lastname: Wang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002162:Camelus; D015536:Down-Regulation; D008070:Lipopolysaccharides / Q000494:pharmacology; D008892:Milk / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D015398:Signal Transduction
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D008070:Lipopolysaccharides; D020928:Mitogen-Activated Protein Kinases
keywords: acute respiratory distress syndrome (ARDS); camel milk (CM); inflammatory response; mitogen-activated protein kinase (MAPK) signaling pathway; oxidative stress