title: Microfocus of Anaplastic Carcinoma Arising in Mural Nodule of Ovarian Mucinous Borderline Tumor With Very Rapid and Fatal Outcome.
abstract: A 36-yr-old woman presented with abdominal discomfort. A computed tomography scan revealed a large left cystic and solid pelvic mass without evidence of metastatic disease. Total hysterectomy with bilateral salpingo-oophorectomy and tumor staging was performed. Grossly, the ovarian mass measured 20×18 cm and the cut surface was multiloculated with 1 single mural nodule measuring 2×1.5 cm. The histologic diagnosis of ovarian mucinous borderline tumor with a microfocus of anaplastic carcinoma arising in sarcoma-like mural nodule, FIGO Stage IA was rendered. After 3 mo, the patient returned with symptomatic anemia. A computed tomography scan showed enlarged retroperitoneal and pelvic lymph nodes. Image-guided biopsy of the pelvic lymph node showed a metastatic anaplastic carcinoma from her primary ovarian carcinoma. Chemotherapy was initiated, but the patient developed fulminant disseminated intravascular coagulation within <1 wk of her presentation which was fatal.
authors.affiliation: Department of Laboratory Medicine and Pathology (P.M.-F., S.W.), Keck School of Medicine Department of Gynecologic Oncology (A.R., H.Q.P., A.Y.), University of Southern California, Los Angeles, California.
authors.forename: Paulette
authors.initials: P
authors.lastname: Mhawech-Fauceglia
authors.forename: Amin
authors.initials: A
authors.lastname: Ramzan
authors.forename: Saloni
authors.initials: S
authors.lastname: Walia
authors.forename: Huyen Q
authors.initials: HQ
authors.lastname: Pham
authors.forename: Annie
authors.initials: A
authors.lastname: Yessaian
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000328:Adult; D002277:Carcinoma / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D012509:Sarcoma / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed