title: Single Nucleotide Polymorphism of Interleukin-18 and Interleukin-18 Receptor and the Risk of Papillary Thyroid Cancer.
abstract: OBJECTIVE
  Growing evidence suggests that interleukin-18 (IL-18) levels may affect neoplasia and that single nucleotide polymorphisms (SNPs) within IL-18 gene may influence its production. In this study, we evaluated whether IL-18 and IL-18 receptor (IL-18R) polymorphisms are associated with the development and clinicopathological features of papillary thyroid carcinoma (PTC).
  
  
  METHODS
  Using direct sequencing, we investigated the association between functional polymorphisms of IL-18 and IL-18R genes and susceptibility to PTC in 94 PTC patients and 260 healthy controls. Genetic data were analyzed using commercially available software. Multiple logistic regression models were used to calculate odds ratios, 95% confidence intervals, and P-values for the association between the genotypes and risk of PTC. The PTC patients were further subgrouped and compared with respect to their clinicopathological characteristics.
  
  
  RESULTS
  3 SNPs of IL-18 (rs549908, rs360717, and rs187238) and one of IL-18R (rs1420106) examined in this study were significantly associated with the development of PTC. The allelic frequencies of the 3 SNPs of IL-18 also showed significant association with lymph node metastasis.
  
  
  CONCLUSIONS
  IL-18 and IL-18R polymorphisms may contribute to the development and lymph node metastasis of PTC.
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, Kyung Hee University, Seoul, Korea, Hoegi-dong, Dongdaemun-gu, Seoul, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, Kyung Hee University, Seoul, Korea, Hoegi-dong, Dongdaemun-gu, Seoul, Korea.
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, Kyung Hee University, Seoul, Korea, Hoegi-dong, Dongdaemun-gu, Seoul, Korea.
authors.forename: Y G
authors.initials: YG
authors.lastname: Eun
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Endocrinology and Metabolism, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S
authors.initials: S
authors.lastname: Chon
authors.affiliation: Department of Endocrinology and Metabolism, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S J
authors.initials: SJ
authors.lastname: Oh
authors.affiliation: Department of Endocrinology and Metabolism, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Rhee
authors.affiliation: Department of Nuclear Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: I K
authors.initials: IK
authors.lastname: Hong
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics*; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D053727:Interleukin-18 Receptor alpha Subunit / Q000235:genetics*; D008207:Lymphatic Metastasis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: C000589760:IL18 protein, human; C508572:IL18R1 protein, human; D020382:Interleukin-18; D053727:Interleukin-18 Receptor alpha Subunit; D009363:Neoplasm Proteins