title: Bridging the Gap: Muscarinic M4 Receptors Promote Striatal Plasticity in Health and Disease.
abstract: In this issue of Neuron, Shen et al. (2015) demonstrate that the M4 muscarinic receptor regulates striatal plasticity. The authors use an M4-positive allosteric modulator, which facilitates long-term depression in direct pathway neurons and reverses aberrant plasticity in levodopa-induced dyskinesia.
authors.affiliation: Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Allison E
authors.initials: AE
authors.lastname: Girasole
authors.affiliation: Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: alexandra.nelson@ucsf.edu.
authors.forename: Alexandra B
authors.initials: AB
authors.lastname: Nelson
mesh_terms: D000818:Animals; D015259:Dopamine Agents / Q000633:toxicity*; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism*; D007980:Levodopa / Q000633:toxicity*; D017072:Neostriatum / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects*; D020734:Parkinsonian Disorders / Q000188:drug therapy*; D020710:RGS Proteins / Q000378:metabolism*; D043588:Receptor, Muscarinic M4 / Q000378:metabolism*
chemical_list: D015259:Dopamine Agents; D020710:RGS Proteins; D043588:Receptor, Muscarinic M4; D007980:Levodopa