title: Essential oil of Algerian Eucalyptus citriodora: Chemical composition, antifungal activity.
abstract: OBJECTIVE
  Essential oil of Eucalyptus citriodora is a natural product which has been attributed for various medicinal uses. In the present investigation, E. citriodora essential oil was used to evaluate its antifungal effect against medically important dermatophytes.
  
  
  METHODS
  Essential oil from the Algerian E. citriodora leaves was analyzed by GC and GC/MS. The antifungal effect of E. citriodora essential oil was evaluated against four dermatophytes: Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum using disc diffusion method, disc volatilization method, and agar dilution method.
  
  
  RESULTS
  The chemical composition of the oil revealed the presence of 22 compounds accounting for 95.27% of the oil. The dominant compounds were citronellal (69.77%), citronellol (10.63%) and isopulegol (4.66%). The disc diffusion method, MIC and MFC determination, indicated that E. citriodora essential oil had a higher antifungal potential against the tested strains with inhibition zone diameter which varied from (12 to 90mm) and MIC and MFC values ranged from (0.6 to 5μL/mL and 1.25 to 5μL/mL) respectively. The M. gypseum was the most resistant to the oil.
  
  
  CONCLUSIONS
  The results of the present study indicated that E. citriodora essential oil may be used as a new antifungal agent recommended by the pharmaceutical industries.
authors.affiliation: Laboratory of reaction engineering, department of process engineering, faculty of mechanical engineering and process engineering, USTHB, PO Box 32 El Alia, Bab Ezzouar, 16111 Algiers, Algeria. Electronic address: htolba@usthb.dz.
authors.forename: H
authors.initials: H
authors.lastname: Tolba
authors.affiliation: Laboratory of reaction engineering, department of process engineering, faculty of mechanical engineering and process engineering, USTHB, PO Box 32 El Alia, Bab Ezzouar, 16111 Algiers, Algeria.
authors.forename: H
authors.initials: H
authors.lastname: Moghrani
authors.affiliation: Laboratory of Mycology, Pasteur Institute, Algiers, Algeria.
authors.forename: A
authors.initials: A
authors.lastname: Benelmouffok
authors.affiliation: Laboratory of Mycology, Pasteur Institute, Algiers, Algeria.
authors.forename: D
authors.initials: D
authors.lastname: Kellou
authors.affiliation: Laboratory of reaction engineering, department of process engineering, faculty of mechanical engineering and process engineering, USTHB, PO Box 32 El Alia, Bab Ezzouar, 16111 Algiers, Algeria.
authors.forename: R
authors.initials: R
authors.lastname: Maachi
mesh_terms: D000080462:Acyclic Monoterpenes; D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology; D000462:Algeria; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects / Q000254:growth & development; D000081005:Cyclohexane Monoterpenes; D005052:Eucalyptus / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000080462:Acyclic Monoterpenes; D000447:Aldehydes; D000935:Antifungal Agents; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; D013729:Terpenes; C409816:isopulegol; C007078:citronellol; C108217:citronellal
keywords: Activité antifongique; Antifungal activity; Composition chimique; Dermatophytes; Essential oil; Eucalyptus Citriodora; Huile essentielle