title: Fibroblast Growth Factor-Inducible 14: Multiple Roles in Tumor Metastasis.
abstract: Metastasis, the main cause of mortality in cancer patients, is a complex process consisting of several sequential, interlinked, and highly-selective steps. Fibroblast growth factor-inducible 14 (Fn14) is one member of the tumor necrosis factor receptor family, which is influential in controlling cell division, life, and death. The role of Fn14 in tumor metastasis regulation is slowly being unraveled, including roles in the regulation of the epithelial-mesenchymal transition, angiogenesis, cytoskeleton modulation, extracellular matrix degradation and inflammation. This review will focus on recent studies that demonstrate the involvement of Fn14 in tumor progression and will briefly describe various pathways of Fn14-regulated metastasis. Finally, future prospects will be discussed for the potential role of Fn14 as a predictive marker and therapeutic agent for tumor metastasis suppression.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Zeng
authors.forename: D N
authors.initials: DN
authors.lastname: Ho
authors.forename: J
authors.initials: J
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China. gangliu.cmitm@xmu.edu.cn.
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D003599:Cytoskeleton / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D000074050:TWEAK Receptor; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D018124:Receptors, Tumor Necrosis Factor; C000613297:TNFRSF12A protein, human; D000074050:TWEAK Receptor; D019869:Phosphatidylinositol 3-Kinases; C000588866:KDR protein, human; D040301:Vascular Endothelial Growth Factor Receptor-2; D048051:p38 Mitogen-Activated Protein Kinases