title: Complement factor H in its alternative identity as adrenomedullin-binding protein 1.
abstract: Complement factor H has been extensively studied since its discovery 50 years ago, and its role in the complement system is quite well established. It has another role, however, as a binding protein for the regulatory peptide adrenomedullin. Part of this role appears to be protection of adrenomedullin from proteolytic degradation. The binding interaction is unusual and merits further investigation. Adrenomedullin has potential therapeutic uses in diseases affecting the vasculature, and factor H has been administered with adrenomedullin in some animal models of disease.
authors.affiliation: Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK; Department of Infection, Immunity and Inflammation, University of Leicester, University Rd, Leicester, LE1 9HN, UK. Electronic address: bob.sim@bioch.ox.ac.uk.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Sim
authors.affiliation: Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK; Centre for Infection, Immunity and Disease Mechanisms, Biosciences, Heinz Wolff Building, Brunel University, London UB8 3PH, UK.
authors.forename: Janez
authors.initials: J
authors.lastname: Ferluga
authors.affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, University Rd, Leicester, LE1 9HN, UK.
authors.forename: Hanan
authors.initials: H
authors.lastname: Al-Rashidi
authors.affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, University Rd, Leicester, LE1 9HN, UK.
authors.forename: Hussein
authors.initials: H
authors.lastname: Abbow
authors.affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, University Rd, Leicester, LE1 9HN, UK.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Schwaeble
authors.affiliation: Centre for Infection, Immunity and Disease Mechanisms, Biosciences, Heinz Wolff Building, Brunel University, London UB8 3PH, UK.
authors.forename: Uday
authors.initials: U
authors.lastname: Kishore
mesh_terms: D053607:Adrenomedullin / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D017242:Complement Factor H / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D004195:Disease Models, Animal; D015870:Gene Expression; D006470:Hemorrhage / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006801:Humans; D011485:Protein Binding; D055550:Protein Stability; D017434:Protein Structure, Tertiary; D059748:Proteolysis; D015427:Reperfusion Injury / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D018805:Sepsis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000473:pathology
chemical_list: D053607:Adrenomedullin; D017242:Complement Factor H; C507862:ADM protein, human; C493495:CFH protein, human
keywords: AMBP1; Adrenomedullin; Complement; Factor H; Haemorrhage; Protein–protein interaction; Sepsis