title: Hand-portable liquid chromatographic instrumentation.
abstract: Over the last four decades, liquid chromatography (LC) has experienced an evolution to smaller columns and particles, new stationary phases and low flow rate instrumentation. However, the development of person-portable LC has not followed, mainly due to difficulties encountered in miniaturizing pumps and detectors, and in reducing solvent consumption. The recent introduction of small, non-splitting pumping systems and UV-absorption detectors for use with capillary columns has finally provided miniaturized instrumentation suitable for high-performance hand-portable LC. Fully integrated microfabricated LC still remains a significant challenge. Ion chromatography (IC) has been successfully miniaturized and applied for field analysis; however, applications are mostly limited to inorganic and small organic ions. This review covers advancements that make possible more rapid expansion of portable forms of LC and IC.
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Sonika
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Chemistry, Southern Illinois University, Carbondale, IL 62901, USA.
authors.forename: Luke T
authors.initials: LT
authors.lastname: Tolley
authors.affiliation: Department of Statistics, Brigham Young University, Provo, UT 84602, USA.
authors.forename: H Dennis
authors.initials: HD
authors.lastname: Tolley
authors.affiliation: VICI Valco Instruments, Houston, Texas 77055, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Plistil
authors.affiliation: VICI Valco Instruments, Houston, Texas 77055, USA.
authors.forename: Stanley D
authors.initials: SD
authors.lastname: Stearns
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA. Electronic address: milton_lee@byu.edu.
authors.forename: Milton L
authors.initials: ML
authors.lastname: Lee
mesh_terms: D002852:Chromatography, Ion Exchange / Q000295:instrumentation / Q000379:methods; D002853:Chromatography, Liquid / Q000295:instrumentation* / Q000379:methods; D008904:Miniaturization
keywords: Ion chromatography; Liquid chromatography; Microchip LC; Miniaturization; Portable