title: Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner.
abstract: Modification of a clinical MRI scanner to enable simultaneous or rapid interleaved acquisition of signals from two different nuclei.
  
  
  
  A device was developed to modify the local oscillator signal fed to the receive channel(s) of an MRI console. This enables external modification of the frequency at which the receiver is sensitive and rapid switching between different frequencies. Use of the device was demonstrated with interleaved and simultaneous31P and1H spectroscopic acquisitions, and with interleaved31P and1H imaging.
  
  
  
  Signal amplitudes and signal-to-noise ratios were found to be unchanged for the modified system, compared with data acquired with the MRI system in the standard configuration.
  
  
  
  Interleaved and simultaneous1H and31P signal acquisition was successfully demonstrated with a clinical MRI scanner, with only minor modification of the RF architecture. While demonstrated with31P, the modification is applicable to any detectable nucleus without further modification, enabling a wide range of simultaneous and interleaved experiments to be performed within a clinical setting. Magn Reson Med 76:1636-1641, 2016. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria. martin.meyerspeer@meduniwien.ac.at.|MR Centre of Excellence, Medical University of Vienna, Austria. martin.meyerspeer@meduniwien.ac.at.|Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. martin.meyerspeer@meduniwien.ac.at.
authors.forename: Martin
authors.initials: M
authors.lastname: Meyerspeer
authors.affiliation: Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.|Department of Radiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Magill
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.|MR Centre of Excellence, Medical University of Vienna, Austria.
authors.forename: Andre
authors.initials: A
authors.lastname: Kuehne
authors.affiliation: Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.|Department of Radiology, University of Lausanne, Lausanne, Switzerland.|Department of Radiology, University of Geneva, Geneva, Switzerland.
authors.forename: Rolf
authors.initials: R
authors.lastname: Gruetter
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.|MR Centre of Excellence, Medical University of Vienna, Austria.
authors.forename: Ewald
authors.initials: E
authors.lastname: Moser
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.|MR Centre of Excellence, Medical University of Vienna, Austria.
authors.forename: Albrecht Ingo
authors.initials: AI
authors.lastname: Schmid
mesh_terms: D066241:Carbon-13 Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D057054:Molecular Imaging / Q000295:instrumentation*; D010759:Phosphorus Isotopes / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018511:Systems Integration
chemical_list: D010759:Phosphorus Isotopes
keywords: MRI; MRS; X-nucleus; interleaved; multinuclear; simultaneous