title: CD4+T helper cell responses to NY-ESO-1 tumor antigen in ovarian cancer resist perversion into immunosuppressive Tregs.
abstract: In a recent study, we have demonstrated that T helper type 1 (TH1) cells specific for the tumor antigen NY-ESO-1 are amplified at ovarian tumor sites but are not "perverted" into immunosuppressive FOXP3+regulatory T cells (Tregs). These findings encourage the development of protocols aiming to eliminate, or inactivate, FOXP3+Tregs and reinforce Type I anticancer immunity, to improve clinical outcomes.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale; Equipe Labellisée Ligue Contre le Cancer; Institut de Cancérologie de l'Ouest ; Nantes-Saint Herblain, France ; Faculty of Medicine; University of Nantes ; Nantes, France.
authors.forename: Danila
authors.initials: D
authors.lastname: Valmori
authors.affiliation: Institut National de la Santé et de la Recherche Médicale; Equipe Labellisée Ligue Contre le Cancer; Institut de Cancérologie de l'Ouest ; Nantes-Saint Herblain, France.
authors.forename: Maha
authors.initials: M
authors.lastname: Ayyoub
keywords: CD4+ T cells; MHC class II tetramers; NY-ESO-1; Treg; ovarian cancer