title: Pulmonary function tests in type 1 diabetes adolescents with diabetic cardiovascular autonomic neuropathy.
abstract: Chronic diabetic complications may afflict all organ tissues including cardiovascular and respiratory system. The aim of the study was to establish if the presence of cardiovascular autonomic neuropathy (CAN) was associated with impaired pulmonary function tests in adolescents with type 1 diabetes (T1D). 46 adolescents with T1D and 25 healthy subjects at the age 15-19years were enrolled to the study. Basic anthropometric data, diabetes onset and duration, plasma glucose and A1c were established. Pulmonary function tests were measured by spirometry and the presence of CAN was examined by heart rate variability. Adolescents with T1D had significantly lower pulmonary function test parameters - FVC (p<0.01), FEV1 (p<0.01), MMEF (p<0.05) and PEFR (p<0.05) compared to the control subjects. In diabetic group, patients with CAN (CAN+, n=19) had significantly lower FVC (p<0.05), FEV1 (p<0.05) and PEFR (p<0.05) compared to patients without CAN (CAN-, n=27). All spirometric parameters were significantly lower in CAN+ subjects compared to healthy controls; however, no significant difference was found in these parameters between CAN- subjects and healthy controls. Spirometric parameters (FVC, FEV1) significantly positively correlated with diabetes onset and body mass index; and negatively correlated with diabetes duration and resting heart rate. Our results indicate that CAN may be associated with reduced pulmonary functions in adolescents with T1D.
authors.affiliation: Pediatric Department, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia; Centre of Experimental and Clinical Respirology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia.
authors.forename: Peter
authors.initials: P
authors.lastname: Ďurdík
authors.affiliation: Pediatric Department, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia; Pediatric Department, University Hospital Martin, Slovakia. Electronic address: jarmilavojtkova@gmail.com.
authors.forename: Jarmila
authors.initials: J
authors.lastname: Vojtková
authors.affiliation: Pediatric Department, University Hospital Martin, Slovakia.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Michnová
authors.affiliation: Pediatric Department, University Hospital Martin, Slovakia.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Turčan
authors.affiliation: Pediatric Department, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia; Centre of Experimental and Clinical Respirology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia.
authors.forename: Anna
authors.initials: A
authors.lastname: Šujanská
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Pavol Jozef Šafárik University in Košice, Faculty of Medicine, Slovakia.
authors.forename: Milan
authors.initials: M
authors.lastname: Kuchta
authors.affiliation: Pediatric Department, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia; Centre of Experimental and Clinical Respirology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia.
authors.forename: Miriam
authors.initials: M
authors.lastname: Čiljaková
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D058065:Diabetic Cardiomyopathies / Q000150:complications*; D003929:Diabetic Neuropathies / Q000150:complications*; D005260:Female; D005541:Forced Expiratory Volume; D006442:Glycated Hemoglobin / Q000032:analysis; D006339:Heart Rate; D006801:Humans; D008168:Lung / Q000294:innervation / Q000503:physiopathology*; D008297:Male; D012131:Respiratory Insufficiency / Q000150:complications*; D012137:Respiratory System / Q000294:innervation / Q000503:physiopathology; D013147:Spirometry; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: adolescents; cardiovascular autonomic neuropathy; pulmonary function; spirometry; type 1 diabetes