title: [Comorbidities of COPD].
abstract: COPD is a slowly progressive chronic respiratory disease causing an irreversible decrease in air flow. The main cause is smoking, which provokes inflammatory phenomena in the respiratory tract. COPD is a serious public health issue, causing high morbidity, mortality and disability. Related comorbidities are linked to ageing, common risk factors and genetic predispositions. A combination of comorbidities increases healthcare costs. For instance, patients with more than two comorbidities represent a quarter of all COPD sufferers but account for half the related health costs. Our review describes different comorbidities and their impact on the COPD prognosis. The comorbidities include: cardiovascular diseases, osteoporosis, denutrition, obesity, ageing, anemia, sleeping disorders, diabetes, metabolic syndrome, anxiety-depression and lung cancer. The prognosis worsens with one or more comorbidities. Clinicians are faced with the challenge of finding practical and appropriate ways of treating these comorbidities, and there is increasing interest in developing a global, multidisciplinary approach to management. Managing this chronic disease should be based on a holistic, patient-centred approach and smoking cessation remains the key factor in the care of COPD patients.
authors.affiliation: Service de pneumologie, CHU Pontchaillou, 2, rue Henri-le-Guilloux, 35033 Rennes cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Brinchault
authors.affiliation: Service de pneumologie, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 9, France.
authors.forename: P
authors.initials: P
authors.lastname: Diot
authors.affiliation: Service de pneumologie et oncologie thoracique, centre hospitalier régional d'Orléans, 14, avenue de l'Hôpital, 45067 Orléans cedex 2, France.
authors.forename: A
authors.initials: A
authors.lastname: Dixmier
authors.affiliation: Service de pneumologie, CH Le Mans, 194, avenue Rubillard, 72037 Le Mans cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Goupil
authors.affiliation: CHP Saint-Martin, 18, rue des Roquemonts, 14000 Caen, France.
authors.forename: P
authors.initials: P
authors.lastname: Guillais
authors.affiliation: Département de pneumologie et médecine interne, CHRU la Cavale-Blanche, boulevard Tanguy-Prigent, 29609 Brest cedex 2, France.
authors.forename: C
authors.initials: C
authors.lastname: Gut-Gobert
authors.affiliation: UBO, EA3878 (GETBO) IFR 148, département de médecine interne et de pneumologie, CHU de la Cavale-Blanche, université européenne de Bretagne, 29609 Brest, France.
authors.forename: C
authors.initials: C
authors.lastname: Leroyer
authors.affiliation: UMR 1100, service de pneumologie et explorations fonctionnelles respiratoires, université François-Rabelais, CHRU de Tours, 37032 Tours, France; UMR 1100/EA6305, Inserm, centre d'étude des pathologies respiratoires, 37032 Tours, France.
authors.forename: S
authors.initials: S
authors.lastname: Marchand-Adam
authors.affiliation: Service de pneumologie du CHU de Poitiers, faculté de médecine et pharmacie de Poitiers, 2, rue de la Milétrie, 86000 Poitiers, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Meurice
authors.affiliation: Service de pneumologie et oncologie thoracique, centre hospitalier régional d'Orléans, 14, avenue de l'Hôpital, 45067 Orléans cedex 2, France.
authors.forename: H
authors.initials: H
authors.lastname: Morel
authors.affiliation: Département de pneumologie, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France.
authors.forename: C
authors.initials: C
authors.lastname: Person
authors.affiliation: Service de pneumologie, l'institut du thorax, CHU de Nantes, boulevard Jacques-Monod, 44093 Nantes cedex 1, France. Electronic address: arnaud.cavailles@chu-nantes.fr.
authors.forename: A
authors.initials: A
authors.lastname: Cavaillès
mesh_terms: D000740:Anemia / Q000150:complications / Q000628:therapy; D001008:Anxiety Disorders / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D002318:Cardiovascular Diseases / Q000150:complications / Q000628:therapy; D003863:Depression / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000628:therapy; D044342:Malnutrition / Q000150:complications / Q000628:therapy; D024821:Metabolic Syndrome / Q000150:complications / Q000628:therapy; D009765:Obesity / Q000150:complications / Q000628:therapy; D010024:Osteoporosis / Q000150:complications / Q000628:therapy; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000628:therapy
keywords: BPCO; COPD; COPD comorbidity; Cardiovascular disease; Comorbidités de la BPCO; Inflammation systémique; Maladies cardiovasculaires; Maladies psychiatriques; Metabolic syndrome; Psychiatric disease; Syndrome métabolique; Systemic inflammation