title: Inhibition of algal bromophenols and their related phenols against glucose 6-phosphate dehydrogenase.
abstract: A novel bromophenol, n-butyl 2,3-dibromo-4,5-dihydroxybenzyl ether, and known bromophenols were isolated from Rhodomelaceae algae as glucose 6-phosphate dehydrogenase (G6PD) inhibitors. Among them, bromophenol dimers showed stronger inhibitory activity against Leuconostoc mesenteroides and Saccharomyces cerevisiae G6PDs than the corresponding monomers. The dibenzyl ether-type dimers had lower IC50 values than the diarylmethane-type dimers against L. mesenteroides G6PD among the bromophenols examined. In contrast, the inhibitory activities of diarylmethane-type dimers against S. cerevisiae G6PD were stronger than those of dibenzyl ether-type dimers. Especially, 3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl methyl ether selectively inhibited S. cerevisiae G6PD compared to L. mesenteroides G6PD.
authors.affiliation: Graduate School of Life Science, Faculty of Advanced Life Science, Hokkaido University, Kita-ku, Sapporo 001-0021, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Mikami
authors.affiliation: Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan. Electronic address: kuri@fish.hokudai.ac.jp.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kurihara
authors.affiliation: Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan.
authors.forename: Momoka
authors.initials: M
authors.lastname: Ono
authors.affiliation: Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Gangwon-do 210-702, Republic of Korea.
authors.forename: Sang Moo
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan.
authors.forename: Koretaro
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D007934:Leuconostoc / Q000187:drug effects / Q000201:enzymology; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D000461:Rhodophyta / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000201:enzymology
chemical_list: D010636:Phenols; D010936:Plant Extracts; D005954:Glucosephosphate Dehydrogenase
keywords: Alga; Bromophenol; Glucose 6-phosphate dehydrogenase; Inhibition; Polyphenol