title: Passive Membrane Permeability: Beyond the Standard Solubility-Diffusion Model.
abstract: The spontaneous diffusion of solutes through lipid bilayers is still a challenge for theoretical predictions. Since permeation processes remain beyond the capabilities of unbiased molecular dynamics simulations, an alternative strategy is currently adopted to gain insight into their mechanism and time scale. This is based on a monodimensional description of the translocation process only in terms of the position of the solute along the normal to the lipid bilayer, which is formally expressed in the solubility-diffusion model. Actually, a role of orientational and conformational motions has been pointed out, and the use of advanced simulation techniques has been proposed to take into account their effect. Here, we discuss the limitations of the standard solubility-diffusion approach and propose a more general description of membrane translocation as a diffusion process on a free energy surface, which is a function of the translational and rotational degrees of freedom of the molecule. Simple expressions for the permeability coefficient are obtained under suitable conditions. For fast solute reorientation, the classical solubility-diffusion equation is recovered. Under the assumption that well-defined minima can be identified on the free energy landscape, a mechanistic interpretation of the permeability coefficient in terms of all possible permeation paths is given.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Padova , Via Marzolo 1, 35131 Padova, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Parisio
authors.affiliation: S-IN Soluzioni Informatiche, Via Ferrari 14, 36100 Vicenza, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Stocchero
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Padova , Via Marzolo 1, 35131 Padova, Italy.
authors.forename: Alberta
authors.initials: A
authors.lastname: Ferrarini