title: Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria.
abstract: Immunoglobulin M (IgM) is an ancient antibody class that is found in all vertebrates, with the exception of coelacanths, and is indispensable in both innate and adaptive immunity. The equally ancient human malaria parasite, Plasmodium falciparum, formed an intimate relationship with IgM with which it co-evolved. In this article, we discuss the association between IgM and human malaria parasites, building on several recent publications that implicate IgM as a crucial molecule that determines both host and parasite survival. Consequently, a better understanding of this association may lead to the development of improved intervention strategies.
authors.affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Electronic address: richard.pleass@lstmed.ac.uk.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Pleass
authors.affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK; Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: Shona C
authors.initials: SC
authors.lastname: Moore
authors.affiliation: Centre for Medical Parasitology, Department of Immunology and Microbiology (ISIM), Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
authors.forename: Liz
authors.initials: L
authors.lastname: Stevenson
authors.affiliation: Centre for Medical Parasitology, Department of Immunology and Microbiology (ISIM), Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark. Electronic address: lhviid@sund.ku.dk.
authors.forename: Lars
authors.initials: L
authors.lastname: Hviid
mesh_terms: D000818:Animals; D006790:Host-Parasite Interactions; D006801:Humans; D057131:Immune Evasion / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D016778:Malaria, Falciparum / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology
chemical_list: D007075:Immunoglobulin M
keywords: Fc receptors; IgM; Plasmodium falciparum; immune evasion; immunoglobulin M