title: Detecting hepatocellular carcinoma in blood.
abstract: Liquid biopsy is ideal for early diagnosis of cancer and for prognosis upon treatment. Wen et al. describe a methylated CpG tandems amplification and sequencing method to profile hypermethylated CpG islands genome-widely in cell-free DNA, and further identify high performance markers in blood for potential detection of early stage hepatocellular carcinoma.
authors.affiliation: Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.|Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Lulu
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.|Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Chuan
authors.initials: C
authors.lastname: He
mesh_terms: D006528:Carcinoma, Hepatocellular; D018899:CpG Islands; D019175:DNA Methylation; D006801:Humans; D008113:Liver Neoplasms; D020411:Oligonucleotide Array Sequence Analysis