title: Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons.
abstract: The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.
authors.affiliation: Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
authors.forename: Erling
authors.initials: E
authors.lastname: Mellerup
authors.affiliation: Department of Psychiatry, Oslo University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166. 0407 Oslo, Norway.
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreassen
authors.affiliation: Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
authors.forename: Bente
authors.initials: B
authors.lastname: Bennike
authors.affiliation: Psychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Dam
authors.affiliation: Department of Medical Genetics, Oslo University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166. 0407 Oslo, Norway.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Djurovic
authors.affiliation: Department of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, Boserupvej 2, DK-4000 Roskilde, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hansen
authors.affiliation: Psychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
authors.forename: Martin Balslev
authors.initials: MB
authors.lastname: Jorgensen
authors.affiliation: Psychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
authors.forename: Lars Vedel
authors.initials: LV
authors.lastname: Kessing
authors.affiliation: Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.|Psychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
authors.forename: Pernille
authors.initials: P
authors.lastname: Koefoed
authors.affiliation: Department of Psychiatry, Oslo University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166. 0407 Oslo, Norway.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Melle
authors.affiliation: Centre for Psyciatric Research, Aarhus University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark.
authors.forename: Ole
authors.initials: O
authors.lastname: Mors
authors.affiliation: Department of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, Boserupvej 2, DK-4000 Roskilde, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.affiliation: Genokey ApS, ScionDTU, Technical University Denmark, Agern Allé 3, DK-2970 Hoersholm, Denmark.
authors.forename: Gert Lykke
authors.initials: GL
authors.lastname: Moeller
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D016000:Cluster Analysis; D003718:Denmark; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D009664:Norway; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors