title: Solubility, photostability and antifungal activity of phenylpropanoids encapsulated in cyclodextrins.
abstract: Effects of the encapsulation in cyclodextrins (CDs) on the solubility, photostability and antifungal activities of some phenylpropanoids (PPs) were investigated. Solubility experiments were carried out to evaluate the effect of CDs on PPs aqueous solubility. Loading capacities and encapsulation efficiencies of freeze-dried inclusion complexes were determined. Moreover, photostability assays for both inclusion complexes in solution and solid state were performed. Finally, two of the most widespread phytopathogenic fungi, Fusarium oxysporum and Botrytis cinerea, were chosen to examine the antifungal activity of free and encapsulated PPs. Results showed that encapsulation in CDs significantly increased the solubility and photostability of studied PPs (by 2 to 17-fold and 2 to 44-fold, respectively). Free PPs revealed remarkable antifungal properties with isoeugenol showing the lowest half-maximal inhibitory concentration (IC50) values of mycelium growth and spore germination inhibition. Encapsulated PPs, despite their reduced antifungal activity, could be helpful to solve drawbacks such as solubility and stability.
authors.affiliation: Bioactive Molecules Research Group, Doctoral School of Science and Technology, Department of Chemistry and Biochemistry, Faculty of Sciences-2, Lebanese University, Lebanon; Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d'Opale (ULCO), F-59140 Dunkerque, France.
authors.forename: Miriana
authors.initials: M
authors.lastname: Kfoury
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d'Opale (ULCO), F-59140 Dunkerque, France.
authors.forename: Anissa
authors.initials: A
authors.lastname: Lounès-Hadj Sahraoui
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d'Opale (ULCO), F-59140 Dunkerque, France.
authors.forename: Natacha
authors.initials: N
authors.lastname: Bourdon
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d'Opale (ULCO), F-59140 Dunkerque, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Laruelle
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d'Opale (ULCO), F-59140 Dunkerque, France.
authors.forename: Joël
authors.initials: J
authors.lastname: Fontaine
authors.affiliation: Bioactive Molecules Research Group, Doctoral School of Science and Technology, Department of Chemistry and Biochemistry, Faculty of Sciences-2, Lebanese University, Lebanon.
authors.forename: Lizette
authors.initials: L
authors.lastname: Auezova
authors.affiliation: Bioactive Molecules Research Group, Doctoral School of Science and Technology, Department of Chemistry and Biochemistry, Faculty of Sciences-2, Lebanese University, Lebanon.
authors.forename: Hélène
authors.initials: H
authors.lastname: Greige-Gerges
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d'Opale (ULCO), F-59140 Dunkerque, France. Electronic address: lamotte@univ-littoral.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Fourmentin
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development; D012995:Solubility; D013172:Spores, Fungal / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D003505:Cyclodextrins
keywords: Cyclodextrin; Encapsulation efficiency; Phenylpropanoids; Photostability; Phytopathogens; Solubility