title: Uniform Surface Modification of 3D Bioglass(®)-Based Scaffolds with Mesoporous Silica Particles (MCM-41) for Enhancing Drug Delivery Capability.
abstract: The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape - both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle coating on the bioactivity of the BG-based scaffolds was assessed. The results indicate that it is possible to obtain a multifunctional scaffold system characterized by high and interconnected porosity, high bioactivity, and sustained drug delivery capability.
authors.affiliation: Institute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander University Erlangen-Nürnberg , Erlangen , Germany.
authors.forename: Elena
authors.initials: E
authors.lastname: Boccardi
authors.affiliation: Institute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander University Erlangen-Nürnberg , Erlangen , Germany.
authors.forename: Anahí
authors.initials: A
authors.lastname: Philippart
authors.affiliation: Institute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander University Erlangen-Nürnberg , Erlangen , Germany.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Juhasz-Bortuzzo
authors.affiliation: Center for Nanoanalysis and Electron Microscopy (CENEM), Institute of Micro- and Nanostructure Research, Department of Materials Science and Engineering, Friedrich-Alexander University Erlangen-Nürnberg , Erlangen , Germany.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Beltrán
authors.affiliation: Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino , Turin , Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Novajra
authors.affiliation: Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino , Turin , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Vitale-Brovarone
authors.affiliation: Center for Nanoanalysis and Electron Microscopy (CENEM), Institute of Micro- and Nanostructure Research, Department of Materials Science and Engineering, Friedrich-Alexander University Erlangen-Nürnberg , Erlangen , Germany.
authors.forename: Erdmann
authors.initials: E
authors.lastname: Spiecker
authors.affiliation: Institute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander University Erlangen-Nürnberg , Erlangen , Germany.
authors.forename: Aldo R
authors.initials: AR
authors.lastname: Boccaccini
keywords: MCM-41; bioactive glass; drug release; ibuprofen; ordered mesoporosity; scaffolds; silica