title: Grouping nanomaterials to predict their potential to induce pulmonary inflammation.
abstract: The rapidly expanding manufacturing, production and use of nanomaterials have raised concerns for both worker and consumer safety. Various studies have been published in which induction of pulmonary inflammation after inhalation exposure to nanomaterials has been described. Nanomaterials can vary in aspects such as size, shape, charge, crystallinity, chemical composition, and dissolution rate. Currently, efforts are made to increase the knowledge on the characteristics of nanomaterials that can be used to categorise them into hazard groups according to these characteristics. Grouping helps to gather information on nanomaterials in an efficient way with the aim to aid risk assessment. Here, we discuss different ways of grouping nanomaterials for their risk assessment after inhalation. Since the relation between single intrinsic particle characteristics and the severity of pulmonary inflammation is unknown, grouping of nanomaterials by their intrinsic characteristics alone is not sufficient to predict their risk after inhalation. The biokinetics of nanomaterials should be taken into account as that affects the dose present at a target site over time. The parameters determining the kinetic behaviour are not the same as the hazard-determining parameters. Furthermore, characteristics of nanomaterials change in the life-cycle, resulting in human exposure to different forms and doses of these nanomaterials. As information on the biokinetics and in situ characteristics of nanomaterials is essential but often lacking, efforts should be made to include these in testing strategies. Grouping nanomaterials will probably be of the most value to risk assessors when information on intrinsic characteristics, life-cycle, biokinetics and effects are all combined.
authors.affiliation: National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands; Department of Toxicogenomics, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands. Electronic address: hedwig.braakhuis@rivm.nl.
authors.forename: Hedwig M
authors.initials: HM
authors.lastname: Braakhuis
authors.affiliation: National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands.
authors.forename: Agnes G
authors.initials: AG
authors.lastname: Oomen
authors.affiliation: National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands; Institute of Risk Assessment Sciences, Utrecht University, PO Box 80.163, 3508 TD Utrecht, The Netherlands.
authors.forename: Flemming R
authors.initials: FR
authors.lastname: Cassee
mesh_terms: D000818:Animals; D005544:Forecasting; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D053768:Metal Nanoparticles / Q000145:classification / Q000633:toxicity; D049329:Nanostructures / Q000145:classification* / Q000633:toxicity*; D010316:Particle Size; D011014:Pneumonia / Q000139:chemically induced*
keywords: Grouping; Inhalation toxicology; Nanoparticles; Risk assessment