title: Psychological trauma exposure and co-morbid psychopathologies in HIV+Men and Women.
abstract: This study examined the association between trauma exposure, PTSD, suicide attempts, and other psychopathology among 316 racially/ethnically diverse HIV-infected men and women who underwent semi-structured psychiatric assessment. In addition, the role of psychological resilience in trauma exposure was examined in the context of neurological symptoms and functional status. Nearly half (47.8%; 151/316) of the participants reported trauma exposure, of which 47.0% (71/151) developed PTSD. Among trauma-exposed individuals, those with a current psychiatric diagnosis reported more neurological symptoms and lower functional status. Trauma exposure without PTSD was associated with a higher rate of panic disorder and substance-induced mental disorders. Trauma-exposed individuals who did not develop PTSD were less likely than those who reported no trauma exposure to meet criteria for major depressive disorder (MDD). Trauma exposure, MDD, borderline personality disorder, and substance-induced mental disorders were independently associated with increased odds of suicide attempt. These results indicate that co-morbid psychiatric disorders are common among trauma exposed individuals with a history of PTSD, but those with trauma exposure who do not develop PTSD are less likely to experience MDD. The role of other co-morbid psychopathologies in the genesis of suicidal behavior among individuals living with HIV deserves further study.
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Fellows
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Nayeli A
authors.initials: NA
authors.lastname: Spahr
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: desiree.byrd@mssm.edu.
authors.forename: Desiree A
authors.initials: DA
authors.lastname: Byrd
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Monica Rivera
authors.initials: MR
authors.lastname: Mindt
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Morgello
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000523:psychology; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000523:psychology; D005260:Female; D015658:HIV Infections / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000523:psychology; D000067073:Psychological Trauma / Q000523:psychology*; D011599:Psychopathology; D055500:Resilience, Psychological; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology / Q000523:psychology*; D019966:Substance-Related Disorders / Q000523:psychology; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000523:psychology*
keywords: Antisocial personality; Borderline personality; Depression; HIV; Panic disorder; Posttraumatic stress disorder; Suicide