title: Mechanical Ventilation and Bronchopulmonary Dysplasia.
abstract: Mechanical ventilation is an important potentially modifiable risk factor for the development of bronchopulmonary dysplasia. Effective use of noninvasive respiratory support reduces the risk of lung injury. Lung volume recruitment and avoidance of excessive tidal volume are key elements of lung-protective ventilation strategies. Avoidance of oxidative stress, less invasive methods of surfactant administration, and high-frequency ventilation are also important factors in lung injury prevention.
authors.affiliation: Department of Pediatrics, Women and Infants Hospital of Rhode Island, Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA. Electronic address: mkeszler@wihri.org.
authors.forename: Martin
authors.initials: M
authors.lastname: Keszler
authors.affiliation: Department of Pediatrics, Neonatal Division, Montreal Children's Hospital, McGill University, 1001 Decarie Boulevard, Room B05.2711, Montreal, Quebec H4A 3J1, Canada.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Sant'Anna
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008168:Lung / Q000254:growth & development*; D063087:Noninvasive Ventilation / Q000379:methods*; D018384:Oxidative Stress; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012121:Respiration, Artificial / Q000379:methods; D012307:Risk Factors; D013990:Tidal Volume
chemical_list: D011663:Pulmonary Surfactants
keywords: Bronchopulmonary dysplasia; Lung-protective ventilation; Mechanical ventilation; Ventilator-associated lung injury; Volume-targeted ventilation