title: Stachyose increases absorption and hepatoprotective effect of tea polyphenols in high fructose-fed mice.
abstract: METHODS
  The consumption of tea polyphenols (TP) and stachyose contributes to preventive effects on hepatic injury. This study examined the effects of stachyose on absorption and hepatoprotective effects of TP in mice.
  
  
  RESULTS
  GC-MS measurement showed that stachyose significantly increased serum total phenolic, ECG and EGCG contents in mice. The mice fed with high fructose (HF)-diet for 56 days exhibited oxidative stress observed by an increase in hepatic MDA levels and decreases in GSH-Px and SOD activities. Serum TC, TG, LDL-C and CRP levels, and ALT and AST activities were increased, while HDL-C concentrations were decreased following HF diet. Co-supplementation of stachyose and TP more effectively improved all parameters mentioned above when compared to administration of stachyose or TP alone. Histological observations of hepatic tissues also confirmed the beneficial effects of co-administration of stachyose and TP.
  
  
  CONCLUSIONS
  Our results suggest that stachyose enhances absorption and hepatoprotective effects of TP, and combined ingestion of stachyose and TP is a novel strategy for alleviating HF diet-induced hepatic injury.
authors.affiliation: College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, P. R. China.
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Li
authors.affiliation: College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, P. R. China.
authors.forename: Di
authors.initials: D
authors.lastname: Huang
authors.affiliation: College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, P. R. China.
authors.forename: Anning
authors.initials: A
authors.lastname: Gao
authors.affiliation: College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, P. R. China.
authors.forename: Xingbin
authors.initials: X
authors.lastname: Yang
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D028241:Camellia sinensis / Q000737:chemistry; D002392:Catechin / Q000097:blood; D005632:Fructose / Q000009:adverse effects*; D008401:Gas Chromatography-Mass Spectrometry; D007408:Intestinal Absorption / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D009844:Oligosaccharides / Q000493:pharmacokinetics / Q000494:pharmacology*; D059808:Polyphenols / Q000493:pharmacokinetics / Q000494:pharmacology*; D020011:Protective Agents / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D009844:Oligosaccharides; D059808:Polyphenols; D020011:Protective Agents; C005695:stachyose; D005632:Fructose; D002392:Catechin
keywords: Absorption; High fructose; Liver damage; Stachyose; Tea polyphenols