title: Clinical Neurochemistry of Subarachnoid Hemorrhage: Toward Predicting Individual Outcomes via Biomarkers of Brain Energy Metabolism.
abstract: The functional outcome of patients with subarachnoid hemorrhage is difficult to predict at the individual level. The monitoring of brain energy metabolism has proven to be useful in improving the pathophysiological understanding of subarachnoid hemorrhage. Nonetheless, brain energy monitoring has not yet clearly been included in official guidelines for the management of subarachnoid hemorrhage patients, likely because previous studies compared only biological data between two groups of patients (unfavorable vs favorable outcomes) and did not determine decision thresholds that could be useful in clinical practice. Therefore, this Viewpoint discusses recent findings suggesting that monitoring biomarkers of brain energy metabolism at the level of individuals can be used to predict the outcomes of subarachnoid hemorrhage patients. Indeed, by taking into account specific neurochemical patterns obtained by local or global monitoring of brain energy metabolism, it may become possible to predict routinely, and with sufficient sensitivity and specificity, the individual outcomes of subarachnoid hemorrhage patients. Moreover, combining both local and global monitoring improves the overall performance of individual outcome prediction. Such a combined neurochemical monitoring approach may become, after prospective clinical validation, an important component in the management of subarachnoid hemorrhage patients to adapt individualized therapeutic interventions.
authors.affiliation: EA 6309 - Myelin Maintenance and Peripheral Neuropathies, University of Limoges , 2 rue du Dr Marcland, 87025 Limoges, France.|Department of Biochemistry and Molecular Genetics, CHU Dupuytren , 2 av Martin Luther King, 87042 Limoges, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Tholance
authors.affiliation: Department of Anesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals , 4 rue Gabrielle-Perret-Gentil, 1211 Geneva, Switzerland.
authors.forename: Gleicy
authors.initials: G
authors.lastname: Barcelos
authors.forename: Frederic
authors.initials: F
authors.lastname: Dailler
authors.affiliation: BioRaN Team, Lyon Neuroscience Research Center, CNRS, UMR 5292, INSERM U1028, Lyon-1 University , 59 bd Pinel, 69677 Bron, France.
authors.forename: Armand
authors.initials: A
authors.lastname: Perret-Liaudet
authors.affiliation: Neurodialytics Unit, Lyon Neuroscience Research Center, CNRS, UMR 5292, INSERM U1028, Lyon-1 University , 8 Avenue Rockefeller, 69008 Lyon, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Renaud
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D013345:Subarachnoid Hemorrhage / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D015415:Biomarkers
keywords: Cerebral microdialysis; delayed cerebral ischemia; elevated hypoxic lactate; functional outcome; metabolic crisis; metabolic ratio; retrograde jugular catheterization; subarachnoid hemorrhage