title: The clinical and therapeutic uses of MDM2 and PSMA and their potential interaction in aggressive cancers.
abstract: Prostate-specific membrane antigen (PSMA) overexpression is observed in the neovasculature of solid tumors, but not in the vasculature of normal tissues. Increased PSMA expression is positively associated with tumor stage and grade, although its function in cancer remains unclear. Mouse double minute 2 (MDM2) is a negative regulator of the p53 tumor suppressor and is reported to regulate VEGF expression and angiogenesis. Both proteins have been considered as biomarkers and therapeutic targets for advanced solid tumors. Our work and a recent microarray-based gene profiling study suggest there could be signaling interplay between MDM2 and PSMA. We herein review the mechanisms underlining the outgrowth of tumors associated with PSMA and MDM2, their potential interaction and how this may be applied to anticancer therapeutics.
authors.affiliation: Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, UK.
authors.forename: Robyn
authors.initials: R
authors.lastname: Bradbury
authors.affiliation: Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, UK.
authors.forename: Wen G
authors.initials: WG
authors.lastname: Jiang
authors.affiliation: Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, UK.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Cui
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism*; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*
chemical_list: D000954:Antigens, Surface; D014408:Biomarkers, Tumor; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II
keywords: MDM2; PSMA; interplay; therapy; tumor