title: Imaging autofluorescence temporal signatures of the human ocular fundus in vivo.
abstract: We demonstrate real-time in vivo fundus imaging capabilities of our fluorescence lifetime imaging technology for the first time. This implementation of lifetime imaging uses light emitting diodes to capture full-field images capable of showing direct tissue contrast without executing curve fitting or lifetime calculations. Preliminary results of fundus images are presented, investigating autofluorescence imaging potential of various retina biomarkers for early detection of macular diseases.
authors.affiliation: University of California, Los Angeles, Electrical Engineering Department, 56-125B Engineering, IV Building, 420 Westwood Plaza, Los Angeles, California 90095-1594, United States.
authors.forename: Asael
authors.initials: A
authors.lastname: Papour
authors.affiliation: University of California, Los Angeles, Department of Bioengineering, 410 Westwood Plaza, Room 5121, Engineering V, P.O. Box 951600, Los Angeles, California 90095-1600, United States.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Taylor
authors.affiliation: University of California, Los Angeles, Electrical Engineering Department, 56-125B Engineering, IV Building, 420 Westwood Plaza, Los Angeles, California 90095-1594, United States.
authors.forename: Oscar
authors.initials: O
authors.lastname: Stafsudd
authors.affiliation: University of California, Los Angeles, Stein Eye Institute and Doheny Eye Institute, 100 Stein Plaza, Los Angeles, California 90095-7000, United States.
authors.forename: Irena
authors.initials: I
authors.lastname: Tsui
authors.affiliation: University of California, Los Angeles, Department of Bioengineering, 410 Westwood Plaza, Room 5121, Engineering V, P.O. Box 951600, Los Angeles, California 90095-1600, United States.
authors.forename: Warren
authors.initials: W
authors.lastname: Grundfest
mesh_terms: D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005451:Fluorescein Angiography / Q000295:instrumentation*; D005654:Fundus Oculi; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D066298:In Vitro Techniques; D008029:Lighting / Q000295:instrumentation*; D008856:Microscopy, Fluorescence / Q000295:instrumentation*; D061848:Optical Imaging / Q000295:instrumentation*; D015203:Reproducibility of Results; D042261:Retinoscopes; D012680:Sensitivity and Specificity; D013552:Swine