title: The Relationship Between High-Sensitivity C-Reactive Protein Levels and Left Ventricular Hypertrophy in Patients With Newly Diagnosed Hypertension.
abstract: The authors aimed to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and presence of left ventricular hypertrophy and diastolic dysfunction in patients with hypertension. A total of 95 newly diagnosed hypertensive patients (mean age, 54±10 years) and 20 controls were included in this study. Patients were divided into four groups according to relative wall thickness as normal, concentric remodeling, concentric, and eccentric hypertrophy. hs-CRP was measured in all patients and serum hs-CRP level was shown to be increased in patients with hypertension compared with controls (0.57 mg/dL vs 0.25 mg/dL, respectively; P<.001). The hs-CRP level was highest in patients with concentric hypertrophy. When compared with controls, serum hs-CRP level was significantly higher in patients with concentric remodeling (0.61±0.3 mg/dL vs 0.43±0.5 mg/dL, P<.030) and concentric hypertrophy (0.69±0.3 mg/dL vs 0.43±0.5 mg/dL, P<.032). The present study shows that serum hs-CRP is significantly associated with left ventricular diastolic function and concentric hypertrophy in patients with hypertension.
authors.affiliation: Department of Cardiology, School of Medicine, Acibadem University, Istanbul, Turkey.
authors.forename: Ergun
authors.initials: E
authors.lastname: Seyfeli
authors.affiliation: Department of Cardiology, Research and Education Hospital, Kayseri, Turkey.
authors.forename: Bahadir
authors.initials: B
authors.lastname: Sarli
authors.affiliation: Department of Cardiology, Research and Education Hospital, Kayseri, Turkey.
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Saglam
authors.affiliation: Department of Cardiology, Research and Education Hospital, Darica, Kocaeli, Turkey.
authors.forename: Can Y
authors.initials: CY
authors.lastname: Karatas
authors.affiliation: Department of Cardiology, Research and Education Hospital, Kayseri, Turkey.
authors.forename: Eyup
authors.initials: E
authors.lastname: Ozkan
authors.affiliation: Department of Cardiology, Research and Education Hospital, Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ugurlu
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000378:metabolism; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein