title: Regulatory Mechanisms Driving Salivary Gland Organogenesis.
abstract: Salivary glands develop as highly branched structures designed to produce and secrete saliva. Advances in mouse genetics, stem cell biology, and regenerative medicine are having a tremendous impact on our understanding of salivary gland organogenesis. Understanding how submandibular gland (SMG) initiation, branching morphogenesis, and cell differentiation occur, as well as defining the progenitor/stem cells and cell and tissue interactions that drive SMG development will help guide regenerative approaches for patients suffering from loss of salivary gland function. This review focuses on recent literature from the past 5 years investigating the regulatory mechanisms driving SMG organogenesis.
authors.affiliation: Matrix and Morphogenesis Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Belinda R
authors.initials: BR
authors.lastname: Hauser
authors.affiliation: Matrix and Morphogenesis Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: mhoffman@mail.nih.gov.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D004848:Epithelium / Q000196:embryology* / Q000378:metabolism; D051526:Fibroblast Growth Factor 10 / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D038081:Organogenesis; D012469:Salivary Glands / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D013363:Submandibular Gland / Q000166:cytology / Q000196:embryology* / Q000378:metabolism
chemical_list: D051526:Fibroblast Growth Factor 10
keywords: Branching morphogenesis; Development; Differentiation; MicroRNAs; Microenvironment; Organogenesis; Progenitor cells; Salivary gland; Salivary stem cell; Stem cell niche