title: Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders.
abstract: Stressor exposure during early life has the potential to increase an individual's susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. This occurs in part due to the dysfunctional stress axis that persists following early adversity impairing stress responsivity across life. The mechanisms underlying the prolonged nature of this vulnerability remain to be established. Alterations in the epigenetic signature of genes involved in stress responsivity may represent one of the neurobiological mechanisms. The overall aim of this review is to provide current evidence demonstrating changes in the epigenetic signature of candidate gene(s) in response to early environmental adversity. More specifically, this review analyses the epigenetic signatures of postnatal adversity such as childhood abuse or maltreatment and later-life psychopathology in human and animal models of early life stress. The results of this review shows that focus to date has been on genes involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and its correlation to subsequent neurobiology, for example, the role of glucocorticoid receptor gene. However, epigenetic changes in other candidate genes such as brain-derived neurotrophic factor (BDNF) and serotonin transporter are also implicated in early life stress (ELS) and susceptibility to adult psychiatric disorders. DNA methylation is the predominantly studied epigenetic mark followed by histone modifications specifically acetylation and methylation. Further, these epigenetic changes are cell/tissue-specific in regulating expression of genes, providing potential biomarkers for understanding the trajectory of early stress-induced susceptibility to adult psychiatric disorders.
authors.affiliation: Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA 5005 Australia.
authors.forename: Magdalene C
authors.initials: MC
authors.lastname: Jawahar
authors.affiliation: School of HealthCare Science, Manchester Metropolitan University, Manchester, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Murgatroyd
authors.affiliation: Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA 5005 Australia ; School of Medicine and Dentistry, James Cook University, Townsville City, Australia.
authors.forename: Emma L
authors.initials: EL
authors.lastname: Harrison
authors.affiliation: Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA 5005 Australia.
authors.forename: Bernhard T
authors.initials: BT
authors.lastname: Baune
keywords: DNA methylation; Early life stress; Epigenetics; Histone acetylation; Maternal separation; Psychopathology; Stress-responsive genes