title: Regioselective Copper-Catalyzed Dicarbonylation of Imidazo[1,2-a]pyridines with N,N-Disubstituted Acetamide or Acetone: An Approach to 1,2-Diketones Using Molecular Oxygen.
abstract: A novel copper-catalyzed regioselective double carbonylation of imidazo[1,2-a]pyridines with N,N-disubstituted acetamide or acetone using molecular oxygen has been described. It has provided a new approach to synthesize 1,2-carbonyl imidazo[1,2-a]pyridines, which are important substrates and intermediates in preparation of fine chemicals. The product shares a skeleton similar to that of Zolpidem, one of the most prescribed drugs in the world. (18)O-labeling experiments unambiguously established that the oxygen source of products originated from O2 rather than H2O.
authors.affiliation: College of Pharmacy, Guangdong Pharmaceutical University , Guangzhou, 510006, P. R. China.
authors.forename: Changcheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Guangdong Pharmaceutical University , Guangzhou, 510006, P. R. China.
authors.forename: Sai
authors.initials: S
authors.lastname: Lei
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Zhongshan, 528458, P. R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Cao
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Zhongshan, 528458, P. R. China.
authors.forename: Shuxian
authors.initials: S
authors.lastname: Qiu
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Zhongshan, 528458, P. R. China.
authors.forename: Jingyun
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Zhongshan, 528458, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Deng
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Zhongshan, 528458, P. R. China.
authors.forename: Caijuan
authors.initials: C
authors.lastname: Yan