title: The Ratio of Dietary Branched-Chain Amino Acids is Associated with a Lower Prevalence of Obesity in Young Northern Chinese Adults: An Internet-Based Cross-Sectional Study.
abstract: This study aims to examine the association between the ratio of dietary branched chain amino acids (BCAA) and risk of obesity among young northern Chinese adults. A total of 948 randomly recruited participants were asked to finish our internet-based dietary questionnaire for the Chinese (IDQC). Associations between dietary BCAA ratio and prevalence of overweight/obesity and abdominal obesity were analyzed. Furthermore, 90 subjects were randomly selected to explore the possible mechanism. Dietary BCAA ratio in obese participants was significantly lower than non-obese participants. We found negative correlations between the ratio of dietary BCAA and body mass index (BMI) (r = -0.197, p < 0.001) or waist circumference (r = -0.187, p < 0.001). Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartiles of dietary BCAA ratio for overweight/obesity were 0.508 (0.265-0.972) and 0.389 (0.193-0.783), respectively (all p < 0.05). After stratification by gender, the significance still existed in the 3rd and 4th quartile in males and the 4th quartile in females. For abdominal obesity, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartile of dietary BCAA ratio were 0.351 (0.145-0.845) and 0.376 (0.161-0.876), respectively (all p < 0.05). This significance was stronger in males. Further studies indicated that dietary BCAA ratio was inversely associated with 2-h postprandial glucose (2 h-PG) and status of inflammation. In conclusion, a higher ratio of dietary BCAA is inversely associated with prevalence of obesity, postprandial glucose and status of inflammation in young northern Chinese adults.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liyanchuan2013@foxmail.com.
authors.forename: Yan-Chuan
authors.initials: YC
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liying_helen@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. yanziliu2100@163.com.
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liushn0505@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. ztq0211@163.com.
authors.forename: Tian-Qi
authors.initials: TQ
authors.lastname: Zi
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. dushanshan1007@163.com.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Du
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China. jiangyongshuai@126.com.
authors.forename: Yong-Shuai
authors.initials: YS
authors.lastname: Jiang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. changhao2002sun@gmail.com.
authors.forename: Ren-Nan
authors.initials: RN
authors.lastname: Feng
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. fengrennan@163.com.
authors.forename: Chang-Hao
authors.initials: CH
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D044466:Asian People; D015992:Body Mass Index; D001835:Body Weight; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D006801:Humans; D020407:Internet; D016015:Logistic Models; D008297:Male; D015596:Nutrition Assessment; D056128:Obesity, Abdominal / Q000453:epidemiology*; D050177:Overweight / Q000453:epidemiology*; D015995:Prevalence; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D000597:Amino Acids, Branched-Chain
keywords: 2 h-PG; abdominal obesity; dietary BCAA; inflammation; overweight/obesity