title: Can we transfer pharmacokinetics/pharmacodynamics of antimicrobials into clinical practice?
abstract: In critically ill patients there is extensive evidence of subtherapeutic antibiotic exposure from standard doses across different antibiotic classes. This can be a direct consequence of pharmacokinetic alterations emanating from the complex pathophysiological processes associated with severe infection. Therapeutic drug monitoring (TDM) is being increasingly used for antibiotic dose optimisation in an attempt to improve the attainment of pharmacokinetic/pharmacodynamic (PK/PD) targets and the outcomes of severe infection in critically ill patients. In clinical practice, it is necessary to reduce the number of blood samples collected from the patient to a minimum because of the cost (personnel, devises and analysis). TDM to calculate PK/PD indices is easily feasible only when a single blood sample is adequate to perform the analysis.
authors.affiliation: Department of Medical Biotechnologies and Translational Medicine, University of Milan, via Vanvitelli 32, Milan, Italy. Electronic address: francesco.scaglione@unimi.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Scaglione
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016638:Critical Illness; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D018805:Sepsis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: Critical illness; Dose optimisation; Pharmacodynamics; Pharmacokinetics; Therapeutic drug monitoring