title: [Apixaban as therapeutic option in nephropathy patients with heparin-induced thrombocytopenia (HIT)].
abstract: Heparin-induced thrombocytopenia (HIT) is a prothrombotic condition caused by antibodies against the heparin-PF4 complex. This disorder is even more problematic in patients undergoing hemodialysis since they are repeatedly exposed to heparin. The diagnostic and therapeutic approach is particularly challenging in this population. We report the case of a woman with chronic kidney disease and a high pretest probability for heparin-induced thrombocytopenia who was acutely treated with apixaban, an oral selective factor Xa inhibitor.
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Delgado-García
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
authors.forename: Roberto
authors.initials: R
authors.lastname: Monreal-Robles
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gallegos-Arguijo
authors.affiliation: Servicio de Hematología. Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
authors.forename: Javier
authors.initials: J
authors.lastname: Marfil-Rivera
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D065427:Factor Xa Inhibitors / Q000627:therapeutic use*; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D011720:Pyrazoles / Q000627:therapeutic use*; D011728:Pyridones / Q000627:therapeutic use*; D006435:Renal Dialysis / Q000379:methods*; D051436:Renal Insufficiency, Chronic / Q000628:therapy*; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D011720:Pyrazoles; D011728:Pyridones; C522181:apixaban; D006493:Heparin