title: [USING MEXICOR TO CORRECT THE FUNCTIONAL PARAMETERS OF RED BLOOD CELLS IN RATS WITH TRAUMATIC BRAIN INJURY MODEL].
abstract: The effect of mexicor on the functional characteristics of erythrocytes under conditions of post-traumatic period has been studied on rats with traumatic brain injury (TBI) model. TBI leads to an increase in the aggregation of erythrocytes by 143% (p = 0.003), increases the concentration of malonic dialdehyde (MDA) by 40% (p = 0.006), and decreases the electrophoretic mobility of erythrocytes by 22% (p = 0.005) relative to the levels of these indices in intact animals. The administration of mexicor (8.0 mg/day, injected intraperitoneally twice per day for 12 days) upon TBI led to a maximum reduction in the MDA concentration by 61% (p = 0.03) and decreased the aggregation of erythrocytes by 36% (p = 0.01), increased the electrophoretic mobility of erythrocytes by 20% (p = 0.003) on the 3rd day of posttraumatic period, and increased the concentrations of 2,3-diphosphoglycerate by 23% (p = 0.02) on the 7th day as compared to the positive control. The most pronounced changes under the action of mexicor were observed within 3 - 7 days after the onset of TBI. The obtained data show the efficacy of mexicor in the treatment of rats with TBI model, which is manifested by a 40% (p = 0.02) shorter period of recovery of the functional parameters of red blood cells in comparison to the positive control.
authors.forename: A V
authors.initials: AV
authors.lastname: Deryugina
authors.forename: V N
authors.initials: VN
authors.lastname: Krylov
authors.forename: A V
authors.initials: AV
authors.lastname: Shumilova
authors.forename: E S
authors.initials: ES
authors.lastname: Filippenko
authors.forename: L V
authors.initials: LV
authors.lastname: Boyarinova
authors.forename: O D
authors.initials: OD
authors.lastname: Solov'eva
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology; D005260:Female; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats
chemical_list: D011725:Pyridines; C517040:ethylmethylhydroxypyridine succinate