title: Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy.
abstract: Anterior commissure involvement is considered to be a risk factor for poorer outcomes after transoral laser cordectomy (TLC) for early glottic cancer. The objective of this study was to determine the outcomes and relevance of the tumor-node-metastasis (TNM) classification in a large series of patients with early glottic cancer involving the anterior commissure treated by TLC.
  
  
  
  The clinical and surgical parameters, as well as follow-up results, of the patients treated consecutively for early-stage glottic squamous cell carcinoma involving the anterior commissure (Tis, T1a, T1b, and T2) by transoral CO2 laser cordectomy in an urban academic medical center from January 2001 to March 2013 were analyzed retrospectively. The main outcomes measures were: 5-year disease free survival (DFS), ultimate local control with laser alone, laryngeal preservation, overall-survival (OS) rates, and disease-specific survival (DSS) rates (Kaplan-Meier).
  
  
  
  Ninety-six patients treated from January 2001 to March 2013 were included. The 5-year DFS and ultimate local control with laser alone rates were 61.7% and 74.4%, respectively. The laryngeal preservation rate was 93.4%; and the OS and DSS rates were 79.2% and 91.5%, respectively. Postoperative T classification (pT) status was not found to be a significant predictor of recurrences, but was predictive of more severe recurrences requiring other treatments than laser.
  
  
  
  TLC is an effective treatment for early stage glottic cancer involving the anterior commissure. The TNM classification is a relevant prognosis factor for severe recurrences.
  
  
  
  4. Laryngoscope, 126:1817-1822, 2016.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Caroline
authors.initials: C
authors.lastname: Hoffmann
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Cornu
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Hans
authors.affiliation: The Sean Parker Institute for the Voice, Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, New York, New York, U.S.A.
authors.forename: Babak
authors.initials: B
authors.lastname: Sadoughi
authors.affiliation: Department of Pathology, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Badoual
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Daniel
authors.initials: D
authors.lastname: Brasnu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009055:Mouth; D012189:Retrospective Studies; D055815:Young Adult
keywords: Laryngeal carcinoma; anterior commissure; glottis; laryngoscopic surgery; squamous cell carcinoma