title: GPCRdb: an information system for G protein-coupled receptors.
abstract: Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front- and back-ends have been re-coded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen, Denmark.
authors.forename: Vignir
authors.initials: V
authors.lastname: Isberg
authors.affiliation: Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Mordalski
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Munk
authors.affiliation: Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Rataj
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen, Denmark.
authors.forename: Kasper
authors.initials: K
authors.lastname: Harpsøe
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen, Denmark.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Hauser
authors.affiliation: Bio-Prodict B.V., Nieuwe Markstraat 54E, 6511 AA, Nijmegen, The Netherlands.
authors.forename: Bas
authors.initials: B
authors.lastname: Vroling
authors.affiliation: Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
authors.forename: Andrzej J
authors.initials: AJ
authors.lastname: Bojarski
authors.affiliation: CMBI, NCMLS, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 26-28, 6525 GA, Nijmegen, The Netherlands.
authors.forename: Gert
authors.initials: G
authors.lastname: Vriend
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen, Denmark david.gloriam@sund.ku.dk.
authors.forename: David E
authors.initials: DE
authors.lastname: Gloriam
mesh_terms: D001665:Binding Sites; D030562:Databases, Protein; D006801:Humans; D008024:Ligands; D009154:Mutation; D010802:Phylogeny; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D012984:Software
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled