title: The multifaceted roles of the HORMA domain in cellular signaling.
abstract: The HORMA domain is a multifunctional protein-protein interaction module found in diverse eukaryotic signaling pathways including the spindle assembly checkpoint, numerous DNA recombination/repair pathways, and the initiation of autophagy. In all of these pathways, HORMA domain proteins occupy key signaling junctures and function through the controlled assembly and disassembly of signaling complexes using a stereotypical "safety belt" peptide interaction mechanism. A recent explosion of structural and functional work has shed new light on these proteins, illustrating how strikingly similar structural mechanisms give rise to radically different functional outcomes in each family of HORMA domain proteins.
authors.affiliation: Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Rosenberg
authors.affiliation: Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093 Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093 kcorbett@ucsd.edu.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Corbett
mesh_terms: D000818:Animals; D001343:Autophagy; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000502:physiology; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints; D064246:Mad2 Proteins / Q000737:chemistry / Q000502:physiology*; D054730:Protein Interaction Domains and Motifs; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction; D040681:Structural Homology, Protein
chemical_list: D004268:DNA-Binding Proteins; C086672:HOP1 protein, S cerevisiae; D064246:Mad2 Proteins; C092219:REV7 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D004259:DNA-Directed DNA Polymerase