title: New insights into microRNAs in skin wound healing.
abstract: Chronic wounds are a major burden to overall healthcare cost and patient morbidity. Chronic wounds affect a large portion of the US, and billions of healthcare dollars are spent in their treatment and management. microRNAs (miRNAs) are small, noncoding double-stranded RNAs that post-transcriptionally downregulate the expression of protein-coding genes. Studies have identified miRNAs involved in all three phases of wound healing including inflammation, proliferation, and remodeling. Some miRNAs have been demonstrated in vitro with primary keratinocyte wound healing model and in vivo with mouse wound healing model through regulation of miRNA expression to affect the wound healing process. This review updates the current miRNAs involved in wound healing and discusses the future therapeutic implications and research directions.
authors.affiliation: Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.|Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
authors.forename: Fatima
authors.initials: F
authors.lastname: Fahs
authors.affiliation: Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.|Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Dermatology, Changhai Hospital, Shanghai, China.
authors.forename: Xinling
authors.initials: X
authors.lastname: Bi
authors.affiliation: Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI, USA.|Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Fu-Shin
authors.initials: FS
authors.lastname: Yu
authors.affiliation: Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.|Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.|Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.|Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
authors.forename: Qing-Sheng
authors.initials: QS
authors.lastname: Mi
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000235:genetics; D003872:Dermatitis / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology; D051379:Mice; D035683:MicroRNAs / Q000502:physiology*; D012867:Skin / Q000293:injuries; D012879:Skin Physiological Phenomena / Q000235:genetics*; D014945:Wound Healing / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: drug discovery; keratinocytes; microRNAs; pathogenesis; skin; wound healing