title: Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population.
abstract: BACKGROUND
  The transcription factor 7-like 2 (TCF7L2) is one of the genes that have been identified as possible determinants of diabetes which is associated with obesity. Data on the genetic causes of obesity in sub-Saharan African populations are very scares. The aim of this study was to assess the association between the transcription factor 7-like 2 (TCF7L2) gene polymorphism (rs12255372 G/T) and obesity and weight-related traits in a Cameroonian population.
  
  
  METHODS
  A case-control study was conducted on 35 obese and 30 non-obese Cameroonian adults. TCF7L2 rs12255372 genotypes were determined using PCR-RFLP and correlated with BMI and weight-related traits.
  
  
  RESULTS
  No significant association was observed between the rs12255372 T allele (χ(2) = 0.0684, p = 0.79) or the TT genotype (χ(2) = 0.372, p = 0.54) of the TCF7L2 gene and obesity in the Cameroonian population. However, amongst the weight-related traits, triglycerides were significantly associated with the T risk allele of the TCF7L2 gene (p = 0.012).
  
  
  CONCLUSIONS
  This study on Cameroonian subjects replicates the absence of association between the TCF7L2 rs12255372 variant and obesity as observed in European and American populations.
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. ngwaelvis73@yahoo.fr.|Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. ngwaelvis73@yahoo.fr.
authors.forename: Elvis Ndonwi
authors.initials: EN
authors.lastname: Ngwa
authors.affiliation: Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. sobngwieugene@yahoo.fr.|Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon. sobngwieugene@yahoo.fr.|National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon. sobngwieugene@yahoo.fr.
authors.forename: Eugene
authors.initials: E
authors.lastname: Sobngwi
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. mma_tiedeu@yahoo.com.|Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. mma_tiedeu@yahoo.com.
authors.forename: Barbara
authors.initials: B
authors.lastname: Atogho-Tiedeu
authors.affiliation: Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa. noubiapjj@yahoo.fr.|Medical Diagnostic Center, Yaoundé, Cameroon. noubiapjj@yahoo.fr.
authors.forename: Jean Jacques N
authors.initials: JJ
authors.lastname: Noubiap
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. olivierdonfack@gmail.com.|Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. olivierdonfack@gmail.com.
authors.forename: Olivier Sontsa
authors.initials: OS
authors.lastname: Donfack
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. guewomagellan@yahoo.fr.|Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. guewomagellan@yahoo.fr.
authors.forename: Magellan
authors.initials: M
authors.lastname: Guewo-Fokeng
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. edithmofo8818@yahoo.fr.|Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. edithmofo8818@yahoo.fr.
authors.forename: Edith Pascale Mato
authors.initials: EP
authors.lastname: Mofo
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. pricillef@yahoo.com.|Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. pricillef@yahoo.com.
authors.forename: Priscille Pokam
authors.initials: PP
authors.lastname: Fosso
authors.affiliation: National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon. ericnoel.djahmeni@yahoo.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Djahmeni
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. rrdtamo@gmail.com.|Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. rrdtamo@gmail.com.
authors.forename: Rosine
authors.initials: R
authors.lastname: Djokam-Dadjeu
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. seveheb@yahoo.com.|Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. seveheb@yahoo.com.
authors.forename: Marie-Solange
authors.initials: MS
authors.lastname: Evehe
authors.affiliation: The Canadian Pharmacogenomics Network for Drug Safety (CPNDS), Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, Canada. faminkeng@yahoo.com.
authors.forename: Folefac
authors.initials: F
authors.lastname: Aminkeng
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon. wfmbacham@yahoo.com.|Laboratory for Public Health Research Biotechnologies, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. wfmbacham@yahoo.com.
authors.forename: Wilfred F
authors.initials: WF
authors.lastname: Mbacham
authors.affiliation: Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé I, Yaoundé, Cameroon. jcmbanya@yahoo.co.uk.|Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon. jcmbanya@yahoo.co.uk.|National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon. jcmbanya@yahoo.co.uk.
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Mbanya
mesh_terms: D000328:Adult; D000483:Alleles; D015992:Body Mass Index; D001835:Body Weight; D002163:Cameroon; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein; D014280:Triglycerides