title: Clinical management of hypophosphatasia.
abstract: HPP is a rare disease that manifests in different ways across the life course. Accurate diagnosis depends upon the use of appropriate age-related normative data. A new therapy is undergoing clinical trials; the preliminary published data is encouraging, but the scope of clinical application remains to be determined.
authors.affiliation: Academic Unit of Child Health, Department of Human Metabolism, University of Sheffield, United Kingdom and Sheffield Children's Hospital, Sheffield, United Kingdom.
authors.forename: Nick
authors.initials: N
authors.lastname: Bishop
keywords: bone mineralisation; enzyme replacement therapy; low alkaline phosphatase; pyrophosphate