title: Alginate-based bipolymeric-nanobioceramic composite matrices for sustained drug release.
abstract: Alginate-based bipolymeric-nanobioceramic composite matrices for sustained drug release were developed through incorporation of nano-hydroxyapatite [nHAp] powders within ionotropically-gelled calcium ion-induced alginate-poly (vinyl pyrrolidone) blends polymeric systems. nHAp powders were synthesized by precipitation technique using calcium hydroxide [Ca(OH)2] and orthophosphoric acid [H3PO4] as raw materials. The average particle size of these was synthesized. nHAp powders was found as 19.04 nm and used to prepare nHAp-alginate-PVP beads containing DS. These beads exhibited drug entrapment efficiency (%) of 65.82±1.88 to 94.45±3.72% and average bead sizes of 0.98±0.07 to 1.23±0.15 mm. These beads were characterized by scanning electron microscopy (SEM) and Fourier transform-infra red (FTIR) spectroscopy analyses. Various nHAp-alginate-PVP beads containing DS exhibited prolonged sustained drug release and followed the Koresmeyer-Peppas model of drug release (R2=0.9908-0.9978) with non-Fickian release (anomalous transport) mechanism (n=0.73-0.84) for drug release over 8 h.
authors.affiliation: Department of Pharmacy, Shri Venkateshwara University, NH-24, Rajabpur, Gajraula, Amroha 244236, UP, India.
authors.forename: M Saquib
authors.initials: MS
authors.lastname: Hasnain
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India. Electronic address: amitkrnayak@yahoo.co.in.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.affiliation: Department of Pharmacy, Shivdan Singh Institute of Technology and Management, Aligarh 202002, UP, India.
authors.forename: Mukul
authors.initials: M
authors.lastname: Singh
authors.affiliation: College of Medicine, Shaqra University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Tabish
authors.affiliation: Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur, Royal College of Medicine, Perak, Ipoh, Malaysia.
authors.forename: Mohammed Tahir
authors.initials: MT
authors.lastname: Ansari
authors.affiliation: Department of Chemistry, L.N.M University, Darbhanga, Bihar, India.
authors.forename: Tahseen Jahan
authors.initials: TJ
authors.lastname: Ara
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation / Q000187:drug effects; D005782:Gels / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D005782:Gels; D006603:Hexuronic Acids; D011108:Polymers; D020723:Glucuronic Acid; D002118:Calcium
keywords: Alginate; Drug release; Nano-hydroxyapatite