title: Redistribution of Proximal and Distal Reabsorption of Water and Ions in Rat Kidney After Treatment with Glucagon-Like Peptide-1 Mimetic.
abstract: Injection of a glucagon-like peptide-1 mimetic accelerated recovery of the initial status of water-salt balance in rats after water or saline load (2.5% NaCl). This effect is mediated by a decrease in proximal fluid reabsorption and change in ion and water transport in the distal part of renal tubules. We developed a new approach to calculation of additional fluid inflow from the proximal tubule to the distal tubule and distal sodium reabsorption under the influence of this mimetic in rats. The expected values corresponded to experimental results, which confirmed our hypothesis on the physiological mechanism for the involvement of the kidneys in the homeostatic effect of glucagon-like peptide-1 under variations in water-salt balance.
authors.affiliation: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. natochin1@mail.ru.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Natochin
authors.affiliation: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Marina
authors.affiliation: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kutina
mesh_terms: D065966:Absorption, Physicochemical; D000818:Animals; D004231:Diuresis / Q000187:drug effects / Q000502:physiology; D000077270:Exenatide; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000819:agonists*; D007477:Ions / Q000378:metabolism*; D007686:Kidney Tubules, Distal / Q000187:drug effects* / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000378:metabolism; D009318:Natriuresis / Q000187:drug effects / Q000502:physiology; D009994:Osmolar Concentration; D064587:Osmoregulation; D010455:Peptides / Q000494:pharmacology*; D010949:Plasma; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D014688:Venoms / Q000494:pharmacology*; D014867:Water / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects* / Q000502:physiology
chemical_list: D007477:Ions; D010455:Peptides; D014688:Venoms; D014867:Water; D052216:Glucagon-Like Peptide 1; D012964:Sodium; D000077270:Exenatide
keywords: glucagon-like peptide-1; kidney; osmoregulation; proximal reabsorption; sodium