title: Comparison of Multiparametric MRI Scoring Systems and the Impact on Cancer Detection in Patients Undergoing MR US Fusion Guided Prostate Biopsies.
abstract: BACKGROUND
  Multiple scoring systems have been proposed for prostate MRI reporting. We sought to review the clinical impact of the new Prostate Imaging Reporting and Data System v2 (PI-RADS) and compare those results to our proposed Simplified Qualitative System (SQS) score with respect to detection of prostate cancers and clinically significant prostate cancers.
  
  
  METHODS
  All patients who underwent multiparametric prostate MRI (mpMRI) had their images interpreted using PI-RADS v1 and SQS score. PI-RADS v2 was calculated from prospectively collected data points. Patients with positive mpMRIs were then referred by their urologists for enrollment in an IRB-approved prospective phase III trial of mpMRI-Ultrasound (MR/TRUS) fusion biopsy of suspicious lesions. Standard 12-core biopsy was performed at the same setting. Clinical data were collected prospectively.
  
  
  RESULTS
  1060 patients were imaged using mpMRI at our institution during the study period. 341 participants were then referred to the trial. 312 participants underwent MR/TRUS fusion biopsy of 452 lesions and were included in the analysis. 202 participants had biopsy-proven cancer (64.7%) and 206 (45.6%) lesions were positive for cancer. Distribution of cancer detected at each score produced a Gaussian distribution for SQS while PI-RADS demonstrates a negatively skewed curve with 82.1% of cases being scored as a 4 or 5. Patient-level data demonstrated AUC of 0.702 (95% CI 0.65 to 0.73) for PI-RADS and 0.762 (95% CI 0.72 to 0.81) for SQS (p< 0.0001) with respect to the detection of prostate cancer. The analysis for clinically significant prostate cancer at a per lesion level resulted in an AUC of 0.725 (95% CI 0.69 to 0.76) and 0.829 (95% CI 0.79 to 0.87) for the PI-RADS and SQS score, respectively (p< 0.0001).
  
  
  CONCLUSIONS
  mpMRI is a useful tool in the workup of patients at risk for prostate cancer, and serves as a platform to guide further evaluation with MR/TRUS fusion biopsy. SQS score provided a more normal distribution of scores and yielded a higher AUC than PI-RADS v2. However until our findings are validated, we recommend reporting of detailed sequence-specific findings. This will allow for prospectively collected data to be utilized in determining the impact of ongoing changes to these scoring systems as our understanding of mpMRI interpretation evolves.
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
authors.forename: Ardeshir R
authors.initials: AR
authors.lastname: Rastinehad
authors.affiliation: Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Waingankar
authors.affiliation: Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Baris
authors.initials: B
authors.lastname: Turkbey
authors.affiliation: Hofstra North Shore LIJ School of Medicine, New Hyde Park, New York, United States of America.
authors.forename: Oksana
authors.initials: O
authors.lastname: Yaskiv
authors.affiliation: Hofstra North Shore LIJ School of Medicine, New Hyde Park, New York, United States of America.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Sonstegard
authors.affiliation: Hofstra North Shore LIJ School of Medicine, New Hyde Park, New York, United States of America.
authors.forename: Mathew
authors.initials: M
authors.lastname: Fakhoury
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
authors.forename: Carl A
authors.initials: CA
authors.lastname: Olsson
authors.affiliation: Hofstra North Shore LIJ School of Medicine, New Hyde Park, New York, United States of America.
authors.forename: David N
authors.initials: DN
authors.lastname: Siegel
authors.affiliation: Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Peter L
authors.initials: PL
authors.lastname: Choyke
authors.affiliation: Hofstra North Shore LIJ School of Medicine, New Hyde Park, New York, United States of America.
authors.forename: Eran
authors.initials: E
authors.lastname: Ben-Levi
authors.affiliation: Hofstra North Shore LIJ School of Medicine, New Hyde Park, New York, United States of America.
authors.forename: Robert
authors.initials: R
authors.lastname: Villani
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012372:ROC Curve; D015203:Reproducibility of Results