title: [An IgG4-related pancreatitis mimicking an adenocarcinoma: A case report].
abstract: Type 1 auto-immune pancreatitis (type 1 AIP) is the pancreatic manifestation of IgG4-related systemic disease (IgG4-RD). This disease has recently been individualized and is characterized by elevated serum IgG4 levels and extrapancreatic lesions with common histologic characteristic: dense infiltration of lymphocytes, IgG4-positive plasma cells and storiforme fibrosis. Obliterative phlebitis is frequently detected. The pancreas is frequently involved in this disease. As approach to the pancreas for histological examination is generally difficult, AIP is diagnosed using a combination of clinical, serological, morphological and histopathological features. In pseudotumoral cases, AIP can be misdiagnosed as pancreatic cancer. Since AIP responds dramatically to steroid therapy, accurate diagnosis of AIP can avoid unnecessary laparotomy or pancreatic resection. We report here a case of a patient who underwent surgery for presumed pancreatic cancer. The final diagnosis was type 1 AIP.
authors.affiliation: Département de biologie et pathologie des tumeurs, service d'anatomie et cytologie pathologiques, CLCC Georges-François-Leclerc, 1, rue Professeur-Marion, 21000 Dijon, France. Electronic address: emilie.degrolard@chu-dijon.fr.
authors.forename: Emilie
authors.initials: E
authors.lastname: Courcet
authors.affiliation: Département de biologie et pathologie des tumeurs, service d'anatomie et cytologie pathologiques, CLCC Georges-François-Leclerc, 1, rue Professeur-Marion, 21000 Dijon, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Beltjens
authors.affiliation: Département de biologie et pathologie des tumeurs, service d'anatomie et cytologie pathologiques, CLCC Georges-François-Leclerc, 1, rue Professeur-Marion, 21000 Dijon, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Charon-Barra
authors.affiliation: Département de radiologie, CLCC Georges-François-Leclerc, 1, rue Professeur-Marion, 21000 Dijon, France.
authors.forename: France
authors.initials: F
authors.lastname: Guy
authors.affiliation: Département de chirurgie, CLCC Georges-François-Leclerc, 1, rue Professeur-Marion, 21000 Dijon, France.
authors.forename: David
authors.initials: D
authors.lastname: Orry
authors.affiliation: Département d'oncologie, CLCC Georges-François-Leclerc, 1, rue Professeur-Marion, 21000 Dijon, France.
authors.forename: François
authors.initials: F
authors.lastname: Ghiringhelli
authors.affiliation: Département de biologie et pathologie des tumeurs, service d'anatomie et cytologie pathologiques, CLCC Georges-François-Leclerc, 1, rue Professeur-Marion, 21000 Dijon, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Arnould
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D003951:Diagnostic Errors; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007074:Immunoglobulin G / Q000032:analysis*; D041781:Jaundice, Obstructive / Q000209:etiology; D007813:Laparotomy; D008297:Male; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D016577:Pancreaticoduodenectomy; D010195:Pancreatitis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery; D015431:Weight Loss
chemical_list: D007074:Immunoglobulin G
keywords: Adénocarcinome pancréatique; Forme pseudotumorale; IgG4-related disease; Maladie sclérosante à IgG4; Pancreatic adenocarcinoma; Pancréatite auto-immune type 1 (PAI type 1); Pseudotumoral case; Type 1 auto-immune pancreatitis (type 1 AIP)