title: Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery.
abstract: Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their combination, in rat models of spinal cord contusion injury. The combined treatment was more effective in improving hindlimb motor function than either treatment alone; injured spinal tissue showed a greater number of neurite-like structures in the injured spinal tissue, somatosensory and motor evoked potential latencies were notably shorter, and their amplitudes greater, after combination therapy than after monotherapy. These findings indicate that Schwann cell transplantation combined with hyperbaric oxygen therapy is more effective than either treatment alone in promoting the recovery of spinal cord in rats after injury.
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Chuan-Gang
authors.initials: CG
authors.lastname: Peng
authors.affiliation: Department of Orthopedics, Tianjin Nankai Hospital, Tianjin, China.
authors.forename: Shu-Quan
authors.initials: SQ
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Min-Fei
authors.initials: MF
authors.lastname: Wu
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Dan-Kai
authors.initials: DK
authors.lastname: Wu
authors.affiliation: Department of Dynaecology and Obstetrics, China-Japan Union Hosptial of Jilin University, Changchun, Jilin Province, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Rui
authors.identifier: 0000-0003-4406-1553
authors.initials: R
authors.lastname: Gu
keywords: Schwann cells; central nervous system; electrophysiology; hyperbaric oxygen therapy; motor function; nerve regeneration; neural regeneration; rats; repair; spinal cord injury; transplantation