title: SNP genotypes of olfactory receptor genes associated with olfactory ability in German Shepherd dogs.
abstract: To find out the relationship between SNP genotypes of canine olfactory receptor genes and olfactory ability, 28 males and 20 females from German Shepherd dogs in police service were scored by odor detection tests and analyzed using the Beckman GenomeLab SNPstream. The representative 22 SNP loci from the exonic regions of 12 olfactory receptor genes were investigated, and three kinds of odor (human, ice drug and trinitrotoluene) were detected. The results showed that the SNP genotypes at the OR10H1-like:c.632C>T, OR10H1-like:c.770A>T, OR2K2-like:c.518G>A, OR4C11-like:c.511T>G and OR4C11-like:c.692G>A loci had a statistically significant effect on the scenting abilities (P < 0.001). The kind of odor influenced the performances of the dogs (P < 0.001). In addition, there were interactions between genotype and the kind of odor at the following loci: OR10H1-like:c.632C>T, OR10H1-like:c.770A>T, OR4C11-like:c.511T>G and OR4C11-like:c.692G>A (P < 0.001). The dogs with genotype CC at the OR10H1-like:c.632C>T, genotype AA at the OR10H1-like:c.770A>T, genotype TT at the OR4C11-like:c.511T>G and genotype GG at the OR4C11-like:c.692G>A loci did better at detecting the ice drug. We concluded that there was linkage between certain SNP genotypes and the olfactory ability of dogs and that SNP genotypes might be useful in determining dogs' scenting potential.
authors.affiliation: Police-dog Technology Department, National Police University of China, Shenyang, Liaoning, 110034, China.
authors.forename: M
authors.initials: M
authors.lastname: Yang
authors.affiliation: Technology Department, Shenyang Traffic Police Detachment, Shenyang, Liaoning, 110001, China.
authors.forename: G-J
authors.initials: GJ
authors.lastname: Geng
authors.affiliation: Forensic Medicine Department, National Police University of China, Shenyang, Liaoning, 110854, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Document Inspection Department, National Police University of China, Shenyang, Liaoning, 110854, China.
authors.forename: L
authors.initials: L
authors.lastname: Cui
authors.affiliation: Mark Inspection Department, National Police University of China, Shenyang, Liaoning, 110854, China.
authors.forename: H-X
authors.initials: HX
authors.lastname: Zhang
authors.affiliation: Forensic Medicine Department, National Police University of China, Shenyang, Liaoning, 110854, China.
authors.forename: J-L
authors.initials: JL
authors.lastname: Zheng
mesh_terms: D000818:Animals; D004285:Dogs / Q000235:genetics*; D005091:Exons; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018035:Receptors, Odorant / Q000235:genetics*; D012903:Smell / Q000235:genetics*
chemical_list: D018035:Receptors, Odorant
keywords: correlation; dog; genetic markers; scenting behavior