title: Maternal Genistein Intake Can Reduce Body Weight in Male Offspring.
abstract: The study objectives were to investigate the relationship between early exposure to genistein and obesity in young adulthood and to evaluate changes in reproductive health during puberty and adulthood following in utero exposure to genistein. Thirty-two female rats were randomized into four groups; low dose 400 mg genistein/kg diet group (LG), mid-dose 1200 mg genistein/kg diet group (MG), high dose 3600 mg genistein/kg diet group (HG), and control group without genistein diet (CON). Rats were fed genistein at the beginning of pregnancy along with a high-fat diet. Pups were sacrificed at week 4 and week 8 after birth. High performance liquid chromatography (HPLC) results showed a correlation between maternal genistein intake and genistein concentration in pups' plasma. Compared to CON, body weight reduced significantly in male HG group at week 8. No statistical differences were found in plasma estradiol (E2), testosterone (T), interleukin (IL)-6, and C-reactive protein (CRP) levels with early genistein exposure. Furthermore, uterine histopathology showed notable changes in groups HG and MG compared with CON at week 4 and week 8. In conclusion, maternal genistein supplement could reduce body weight in male pups and alter uterine histopathology in female pups.
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150081, Heilongjiang, China.
authors.forename: Yun Bo
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital of Heilongjiang University of Traditional Chinese, Harbin 150040, Heilongjiang, China.
authors.forename: Jing Dong
authors.initials: JD
authors.lastname: Yan
authors.affiliation: The First Affiliated Hospital of Heilongjiang University of Traditional Chinese, Harbin 150040, Heilongjiang, China.
authors.forename: Su Qing
authors.initials: SQ
authors.lastname: Yang
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150081, Heilongjiang, China.
authors.forename: Ji Peng
authors.initials: JP
authors.lastname: Guo
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150081, Heilongjiang, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150081, Heilongjiang, China.
authors.forename: Xiao Xi
authors.initials: XX
authors.lastname: Sun
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150081, Heilongjiang, China.
authors.forename: Xiao Lin
authors.initials: XL
authors.lastname: Na
authors.affiliation: Department of Ultrasonography, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang, China.
authors.forename: Shao Chun
authors.initials: SC
authors.lastname: Dai
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D019833:Genistein / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D051381:Rats; D014599:Uterus / Q000254:growth & development
chemical_list: D004041:Dietary Fats; D019833:Genistein