title: Total Lesion Glycolysis and Sequential (90)Y-Selective Internal Radiation Therapy in Breast Cancer Liver Metastases: Preliminary Results.
abstract: To assess the prognostic role of total lesion glycolysis (TLG) in patients with breast cancer liver metastases (BCLM) after sequential lobar (90)Y-radioembolization ((90)Y-RE). Seventeen patients with bilobar BCLM underwent FDG PET/CT and TLG calculation before (90)Y-RE. The hepatic lobe with the highest TLG was treated in the first session. PET was performed 6 weeks postprocedure and decrease in TLG (ΔTLG) in the treated lobe was calculated before the second (90)Y administration. Subjects were divided in two groups (group 1: ΔTLG >50%, group 2: ΔTLG <50%). After the two consecutive (90)Y-therapies, patients underwent follow-up until death. Statistical analysis was performed to identify prognostic factors on overall survival (OS). After the first (90)Y administration, 10 cases showed a ΔTLG >50% and seven had a ΔTLG value <50%. After the two consecutive procedures, the mean OS for all patients was 13.5 ± 0.8 months. Subjects with a ΔTLG >50% and ΔTLG <50% had a mean OS of 16.4 ± 0.6 and 10.3 ± 0.4 months, respectively (p < 0.001). Cox regression analysis demonstrated hepatic tumor load (p = 0.048) and ΔTLG as the only significant (p = 0.005) predictors of survival. ΔTLG after the first (90)Y administration agrees with final outcome in BCLM patients after separate sequential lobar (90)Y-RE.
authors.affiliation: 1 Department of Nuclear Medicine, Santa Maria Goretti Hospital , Latina, Italy .
authors.forename: Oreste
authors.initials: O
authors.lastname: Bagni
authors.affiliation: 1 Department of Nuclear Medicine, Santa Maria Goretti Hospital , Latina, Italy .
authors.forename: Luca
authors.initials: L
authors.lastname: Filippi
authors.affiliation: 2 Department of Interventional Radiology, Santa Maria Goretti Hospital , Latina, Italy .
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pelle
authors.affiliation: 2 Department of Interventional Radiology, Santa Maria Goretti Hospital , Latina, Italy .
authors.forename: Roberto
authors.initials: R
authors.lastname: Cianni
authors.affiliation: 3 Department of Biomedicine and Prevention, University Tor Vergata , Rome, Italy .
authors.forename: Orazio
authors.initials: O
authors.lastname: Schillaci
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004621:Embolization, Therapeutic / Q000009:adverse effects; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006019:Glycolysis; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D008875:Middle Aged; D049268:Positron-Emission Tomography; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden; D015021:Yttrium Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D014408:Biomarkers, Tumor; D015021:Yttrium Radioisotopes; D019788:Fluorodeoxyglucose F18
keywords: 90Y-radioembolization; FDG-PET; breast cancer; liver metastases; total lesion glycolysis