title: [Recent advances in transmissible tumors].
abstract: Transmissible tumors are a class of tumor that can be transmitted between individuals through living cells. So far, four types of transmissible tumors including canine transmissible venereal tumor (CTVT),Tasmanian devil facial tumor disease (DFTD), soft-shell clams leukemia (SSCL), and hamsters reticulum cell sarcoma (HRCS)have been discovered and identified. In the last decades, these transmissible tumors have been proved to be transmitted through living cells by cytological, histological and genetic studies. CTVT, the oldest mammalian somatic cell line, and DFTD originated from Schwann cell have been reported to avoid immunological recognition by down-regulating MHC expression, while a high copy number of Steamer retrotransposon is commonly exist in SSCL. In recent years, the whole-genome sequencing of CTVT and DFTD have been completed which facilitates studies on the mechanisms of tumorigenesis, transmission and evolution of transmissible tumors at the whole-genome level. In this review, we summarize the recent advances in transmissible tumors and discuss the research focus in next decade.
authors.affiliation: 1. Molecular Evolution and Genome Diversity Lab, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; 2. Kunming College of Life Science, University of Chinese Academy of Sciences,Kunming 650204, China;
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Yin
authors.affiliation: Laboratory for Conservation and Utilization of Bio-resources & Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, Yunnan University, Kunming 650091,China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Molecular Evolution and Genome Diversity Lab, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
authors.forename: Guo-dong
authors.initials: GD
authors.lastname: Wang
mesh_terms: D000818:Animals; D006224:Cricetinae; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D006801:Humans; D007938:Leukemia / Q000662:veterinary*; D008228:Lymphoma, Non-Hodgkin / Q000662:veterinary*; D049892:Mya; D014685:Venereal Tumors, Veterinary / Q000235:genetics*