title: N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives.
abstract: BACKGROUND
  Silent brain infarcts (SBIs) are highly prevalent in the aged population and relate to the occurrence of further stroke and dementia. Serum N-glycome levels have been previously associated with aging and they might be related as well to the presence of SBIs and age-related white matter hyperintensities.
  
  
  RESULTS
  We determined the serum N-glycome profile in a cohort study comprising 972 subjects and evaluated the relationship between N-glycome levels and the presence and number of SBIs and with age-related white matter hyperintensities grades, assessed by brain magnetic resonance imaging. Decreasing concentrations of bigalacto core-α-1,6-fucosylated biantennary glycan and increasing concentrations of branching α-1,3-fucosylated triantennary glycan remained as independent predictors of SBIs (odds ratio 0.4, 95% CI 0.3-0.7 and odds ratio 1.8, 95% CI 1-3.2, respectively), after controlling for the presence of age and classic vascular risk factors. A similar pattern was found to be related to an increasing number of SBIs and white matter hyperintensities grade.
  
  
  CONCLUSIONS
  N-glycome levels might be potentially useful as biomarkers for the presence of silent cerebrovascular disease.
authors.affiliation: Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.).
authors.forename: Andrea
authors.initials: A
authors.lastname: Vilar-Bergua
authors.affiliation: Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.).
authors.forename: Iolanda
authors.initials: I
authors.lastname: Riba-Llena
authors.affiliation: Inflammation Research Center, UGent-VIB Research Building FSVM, Ghent, Belgium (V.V., S.D., C.L.) Biomedical Molecular Biology Department, Ghent University, Ghent, Belgium (V.V., S.D., C.L.).
authors.forename: Valerie
authors.initials: V
authors.lastname: Vanhooren
authors.affiliation: Inflammation Research Center, UGent-VIB Research Building FSVM, Ghent, Belgium (V.V., S.D., C.L.) Biomedical Molecular Biology Department, Ghent University, Ghent, Belgium (V.V., S.D., C.L.).
authors.forename: Sylviane
authors.initials: S
authors.lastname: Dewaele
authors.affiliation: Inflammation Research Center, UGent-VIB Research Building FSVM, Ghent, Belgium (V.V., S.D., C.L.) Biomedical Molecular Biology Department, Ghent University, Ghent, Belgium (V.V., S.D., C.L.).
authors.forename: Claude
authors.initials: C
authors.lastname: Libert
authors.affiliation: Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.).
authors.forename: Anna
authors.initials: A
authors.lastname: Penalba
authors.affiliation: Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.) Stroke Unit, Neurology Department, Vall d'Hebron Hospital, Barcelona, Spain (J.M.).
authors.forename: Joan
authors.initials: J
authors.lastname: Montaner
authors.affiliation: Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (A.V.B., I.R.L., A.P., J.M., P.D.).
authors.forename: Pilar
authors.initials: P
authors.lastname: Delgado
mesh_terms: D000368:Aged; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D020520:Brain Infarction / Q000097:blood* / Q000209:etiology / Q000473:pathology; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D054794:Glycomics / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D056784:Leukoencephalopathies / Q000097:blood* / Q000209:etiology / Q000473:pathology; D016014:Linear Models; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011134:Polysaccharides / Q000097:blood*; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D011134:Polysaccharides
keywords: N‐glycome profile; aging; biomarker; silent brain infarct; white matter hyperintensities