title: Measurement of phthalates diesters in food using gas chromatography-tandem mass spectrometry.
abstract: An analytical strategy dedicated to 4 major phthalate diesters (DiBP, DnBP, BBzP and DEHP) monitoring in food items has been developed and validated according to normalized guidelines. The method has been applied to a wide range of foodstuffs (n=54) to generate first-ever occurrence data at the French level. This method involves separation and detection using gas chromatography coupled to tandem mass spectrometry, in electron ionisation with highly specific selected reaction monitoring, quantification being performed according to the isotope dilution principle. A particular attention has been paid to background contamination management at any stage of the analytical process, from the sampling to the expression of the results. Limits of reporting, defined as statistically different from background contamination, were found to be 2.7, 0.53, 0.18 and 3.4 μg kg(-1), and relative combined uncertainties were finally found to be 7.6%, 12.2%, 12.0% and 14.1%, for DiBP, DnBP, BBzP and DEHP, respectively.
authors.affiliation: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France. Electronic address: laberca@oniris-nantes.fr.
authors.forename: Ronan
authors.initials: R
authors.lastname: Cariou
authors.affiliation: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Larvor
authors.affiliation: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Monteau
authors.affiliation: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Marchand
authors.affiliation: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Bichon
authors.affiliation: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Gaud
authors.initials: G
authors.lastname: Dervilly-Pinel
authors.affiliation: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France; INRA, Nantes F-44307, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Antignac
authors.affiliation: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
mesh_terms: D005504:Food Analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010795:Phthalic Acids / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D010795:Phthalic Acids; C032279:phthalic acid
keywords: Bis(2-ethylhexyl) phthalate (PubChem CID: 8343); Butyl benzyl phthalate (PubChem CID: 2347); Di-iso-butyl phthalate (PubChem CID: 6782); Di-n-butyl phthalate (PubChem CID: 3026); Foodstuffs; GC–MS/MS; Phthalate; Procedural contamination; Validation