title: Multistimuli-Regulated Photochemothermal Cancer Therapy Remotely Controlled via Fe5C2 Nanoparticles.
abstract: Stimuli-controlled drug delivery and release is of great significance in cancer therapy, making a stimuli-responsive drug carrier highly demanded. Herein, a multistimuli-controlled drug carrier was developed by coating bovine serum albumin on Fe5C2 nanoparticles (NPs). With a high loading of the anticancer drug doxorubicin, the nanoplatform provides a burst drug release when exposed to near-infrared (NIR) light or acidic conditions. In vitro experiment demonstrated a NIR-regulated cell inhibition that is ascribed from cellular uptake of the carrier and the combination of photothermal therapy and enhanced drug release. The carrier is also magnetic-field-responsive, which enables targeted drug delivery under the guidance of a magnetic field and monitors the theranostic effect by magnetic resonance imaging. In vivo synergistic effect demonstrates that the magnetic-driven accumulation of NPs can induce a complete tumor inhibition without appreciable side effects to the treated mice by NIR irradiation, due to the combined photochemotherapy. Our results highlight the great potential of Fe5C2 NPs as a remote-controlled platform for photochemothermal cancer therapy.
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Ju
authors.affiliation: Key Laboratory of Advanced Materials, Ministry of Education, School of Material Science & Engineering, Tsinghua University , Beijing 100084, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Chu
authors.forename: Wenlong
authors.initials: W
authors.lastname: Yang
authors.forename: Yonglu
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Radiology, Affiliated Hospital of the Academy of Military Medical Sciences , Beijing 100071, China.
authors.forename: Fugeng
authors.initials: F
authors.lastname: Sheng
authors.forename: Jian
authors.initials: J
authors.lastname: Lin
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Yunhe
authors.initials: Y
authors.lastname: Dong
authors.forename: Yanglong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D017554:Carbon Compounds, Inorganic / Q000737:chemistry; D002417:Cattle; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004298:Dopamine / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D058085:Iron Compounds / Q000737:chemistry; D008027:Light; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D017554:Carbon Compounds, Inorganic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D058085:Iron Compounds; D058185:Magnetite Nanoparticles; C541825:iron carbide; D012710:Serum Albumin, Bovine; D004317:Doxorubicin; D004298:Dopamine
keywords: iron carbide nanoparticles; magnetic targeting; photochemothermal therapy; stimuli-responsive