title: miR-122 inhibits metastasis and epithelial-mesenchymal transition of non-small-cell lung cancer cells.
abstract: miR-122 may function as a novel tumor suppressor. Expression of miR-122 could suppress the proliferation of multi-kinds of human cancer cell lines. In this work, expression of miR-122 via adenoviral vector in non-small-cell lung cancer (NSCLC) cells reduces the number of invasion and migration cells. miR-122 attenuates the epithelial-mesenchymal transition process, which mediates cancer cells metastasis in NSCLC cells A549 and H460. The mechanisms data reveals that miR-122 would disrupt the epithelial-mesenchymal transition process by downregulating PI3K/AKT activation via reducing endogenous expression of insulin-like growth factor 1 receptor. These data highlight the detailed roles and potential application of miR-122 in NSCLC cells.
authors.affiliation: Department of Pulmonary Neoplasm Internal Medicine, Affiliated Hospital of Academy of the Military Medical Sciences, Beijing, People's Republic of China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of Rehabilitation, Zhangqiu City People's Hospital, Zhangqiu, People's Republic of China.
authors.forename: Jiping
authors.initials: J
authors.lastname: Sha
authors.affiliation: Department of Endocrinology, Zhangqiu City People's Hospital, Zhangqiu, People's Republic of China.
authors.forename: Caixia
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Rehabilitation, Zhangqiu City People's Hospital, Zhangqiu, People's Republic of China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Pulmonary Neoplasm Internal Medicine, Affiliated Hospital of Academy of the Military Medical Sciences, Beijing, People's Republic of China.
authors.forename: Lili
authors.initials: L
authors.lastname: Qu
authors.affiliation: Department of Oncology, Cancer Hospital of Ci County, Handan, People's Republic of China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Oncology, 477 Hospital of People's Liberation Army, Xiangyang, People's Republic of China.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Xu
authors.affiliation: Center of Technical and Service, the 302nd Hospital of People's Liberation Army, Beijing, People's Republic of China.
authors.forename: Qiyu
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Pulmonary Neoplasm Internal Medicine, Affiliated Hospital of Academy of the Military Medical Sciences, Beijing, People's Republic of China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Gao
keywords: PI3K/AKT signaling pathway; epithelial-mesenchymal transition; metastasis; microRNA-122; tumor suppressor