title: Exposing Differences in Monomer Exchange Rates of Multicomponent Supramolecular Polymers in Water.
abstract: The formation of multicomponent and bioactive supramolecular polymers is a promising strategy for the formation of biomaterials that match the dynamic and responsive nature of biological systems. In order to fully realize the potential of this strategy, knowledge of the location and behavior of bioactive components within the system is crucial. By employing synthetic strategies to create multifunctional monomers, coupled with FRET and STORM techniques, we have investigated the formation and behavior of a bioactive and multicomponent supramolecular polymer. By creating a peptide-dye-monomer conjugate, we were able to measure high degrees of monomer incorporation and to visualize the equal distribution of monomers within the supramolecular polymer. Furthermore, by tracking the movement of monomers, we uncovered small differences in the dynamics of the bioactive monomers.
authors.affiliation: Institute of Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.|MERLN Institute for Technology-Inspired Tissue Regeneration, University of Maastricht, P. O. Box 616, 6200 MD, Maastricht, The Netherlands.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Baker
authors.affiliation: Institute of Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.
authors.forename: Ronald P J
authors.initials: RP
authors.lastname: Gosens
authors.affiliation: Institute of Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Albertazzi
authors.affiliation: Institute of Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Matsumoto
authors.affiliation: Institute of Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.
authors.forename: Anja R A
authors.initials: AR
authors.lastname: Palmans
authors.affiliation: Institute of Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands. e.w.meijer@tue.nl.
authors.forename: E W
authors.initials: EW
authors.lastname: Meijer
mesh_terms: D001549:Benzamides / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002232:Carbocyanines / Q000737:chemistry; D004396:Coloring Agents / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D009842:Oligopeptides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D014867:Water / Q000737:chemistry*
chemical_list: D001549:Benzamides; D001672:Biocompatible Materials; D002232:Carbocyanines; D004396:Coloring Agents; D009842:Oligopeptides; D011108:Polymers; C558700:benzene-1,3,5-tricarboxamide; C085321:cyanine dye 5; D014867:Water; D011092:Polyethylene Glycols; C046617:arginyl-glycyl-aspartyl-serine
keywords: biological activity; copolymerization; dynamics; peptides; self-assembly