title: Neuropsychological profile in adult schizophrenia measured with the CMINDS.
abstract: Schizophrenia neurocognitive domain profiles are predominantly based on paper-and-pencil batteries. This study presents the first schizophrenia domain profile based on the Computerized Multiphasic Interactive Neurocognitive System (CMINDS(®)). Neurocognitive domain z-scores were computed from computerized neuropsychological tests, similar to those in the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB), administered to 175 patients with schizophrenia and 169 demographically similar healthy volunteers. The schizophrenia domain profile order by effect size was Speed of Processing (d=-1.14), Attention/Vigilance (d=-1.04), Working Memory (d=-1.03), Verbal Learning (d=-1.02), Visual Learning (d=-0.91), and Reasoning/Problem Solving (d=-0.67). There were no significant group by sex interactions, but overall women, compared to men, showed advantages on Attention/Vigilance, Verbal Learning, and Visual Learning compared to Reasoning/Problem Solving on which men showed an advantage over women. The CMINDS can readily be employed in the assessment of cognitive deficits in neuropsychiatric disorders; particularly in large-scale studies that may benefit most from electronic data capture.
authors.affiliation: Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA. Electronic address: tvanerp@uci.edu.
authors.forename: Theo G M
authors.initials: TG
authors.lastname: van Erp
authors.affiliation: Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA.
authors.forename: Adrian
authors.initials: A
authors.lastname: Preda
authors.affiliation: Departments of Psychology and Neuroscience, Georgia State University, Atlanta, GA 30303, USA; Mind Research Network, Albuquerque, NM 87106, USA.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Turner
authors.affiliation: Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA.
authors.forename: Shawn
authors.initials: S
authors.lastname: Callahan
authors.affiliation: Mind Research Network, Albuquerque, NM 87106, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM 97106, USA; Departments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Vince D
authors.initials: VD
authors.lastname: Calhoun
authors.affiliation: Departments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Juan R
authors.initials: JR
authors.lastname: Bustillo
authors.affiliation: Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA.
authors.forename: Kelvin O
authors.initials: KO
authors.lastname: Lim
authors.affiliation: Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA.
authors.forename: Bryon
authors.initials: B
authors.lastname: Mueller
authors.affiliation: VA San Diego Healthcare System and Department of Psychiatry, University of California San Diego, CA 92161, USA.
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Brown
authors.affiliation: Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
authors.forename: Jatin G
authors.initials: JG
authors.lastname: Vaidya
authors.affiliation: Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: McEwen
authors.affiliation: Departments of Psychiatry and Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Aysenil
authors.initials: A
authors.lastname: Belger
authors.affiliation: Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: James
authors.initials: J
authors.lastname: Voyvodic
authors.affiliation: Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Mathalon
authors.affiliation: Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA.
authors.forename: Dana
authors.initials: D
authors.lastname: Nguyen
authors.affiliation: Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Ford
authors.affiliation: Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Potkin
mesh_terms: D000328:Adult; D001288:Attention; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D011340:Problem Solving; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012737:Sex Factors; D065853:Spatial Learning; D013850:Thinking; D014706:Verbal Learning
keywords: MATRICS; MCCB; Memory; Neuropsychology; Psychosis; Sex; Speed of processing