title: JC Virus Replication at the First Symptoms of Multiple Sclerosis: A Case Report.
abstract: Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown etiology, in which viruses have been suggested as etiological/triggering agents. The attention to the association between viruses and MS has been rekindled by the development of progressive multifocal leukoencephalopathy in natalizumab-treated MS patients. Here we report the case of a woman with JC virus (JCV) replication in the cerebrospinal fluid, blood and urine collected at the first symptoms of MS and during several follow-up visits. This observation shows that JCV can be associated with MS without a relation with natalizumab treatment, although the triggering role of JCV in some cases of MS will require further studies.
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Delbue
authors.forename: Carlo Sebastiano
authors.initials: CS
authors.lastname: Tadeo
authors.forename: Francesca
authors.initials: F
authors.lastname: Elia
authors.forename: Pasquale
authors.initials: P
authors.lastname: Ferrante
mesh_terms: D001769:Blood / Q000821:virology; D002555:Cerebrospinal Fluid / Q000821:virology; D005260:Female; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification*; D009103:Multiple Sclerosis / Q000209:etiology*; D027601:Polyomavirus Infections / Q000150:complications* / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications* / Q000821:virology; D014556:Urine / Q000821:virology