title: Effects of Chronic Endurance Exercise on Doxorubicin-Induced Thymic Damage.
abstract: The use of prior exercise training has shown promise in minimizing doxorubicin (DOX)-induced physical impairments. The purpose of this study was to compare changes in thymus mass, thymocyte (T-cell) number, and tissue peroxidation following chronic endurance exercise and DOX treatment in the rat. The thymus mass, number of viable T-cells, and levels of malondialdehyde and 4-hydroxyalkenals (MDA+4-HAE) were compared 3 days post-injection between rats assigned to the following treatment conditions: (a) 10 weeks of endurance training, followed by a saline injection 24 hours after the last training session (TM+SAL); (b) treadmill training as above, followed by a single, bolus 10-mg/kg injection of DOX (TM+10); (c) treadmill training with 12.5 mg/kg of DOX (TM+12.5); (d) sedentary (without exercise) and a saline injection (SED+SAL); (e) sedentary with 10 mg/kg of DOX (SED+10); and (f) sedentary with 12.5 mg/kg (SED+12.5). Thymic mass and T-cell numbers significantly decreased following DOX injections. TM rats exhibited significantly less lipid peroxidation compared with paired-dose SED groups. TM+10 did not significantly differ from SED+SAL in thymic levels of lipid peroxidation. We conclude that chronic endurance exercise decreases levels of lipid peroxidation in the thymus seen with acute DOX treatment.
authors.affiliation: University of Northern Colorado, Greeley, CO, USA.
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Quinn
authors.affiliation: University of Northern Colorado, Greeley, CO, USA.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Burns
authors.affiliation: University of Northern Colorado, Greeley, CO, USA.
authors.forename: Noah M
authors.initials: NM
authors.lastname: Gibson
authors.affiliation: University of Northern Colorado, Greeley, CO, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Bashore
authors.affiliation: University of Northern Colorado, Greeley, CO, USA.
authors.forename: Reid
authors.initials: R
authors.lastname: Hayward
authors.affiliation: University of Northern Colorado, Greeley, CO, USA David.Hydock@unco.edu.
authors.forename: David S
authors.initials: DS
authors.lastname: Hydock
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000503:physiopathology*; D005081:Exercise Therapy / Q000379:methods; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D010807:Physical Endurance / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013601:T-Lymphocytes / Q000187:drug effects; D060168:Thymocytes / Q000187:drug effects*; D013950:Thymus Gland / Q000187:drug effects*
chemical_list: D004317:Doxorubicin
keywords: Adriamycin; anthracycline; lipid peroxidation; physical activity; thymocyte