title: Synthesis of 4-Arylthieno[2,3-b]pyridines and 4-Aminothieno[2,3-b]pyridines via a Regioselective Bromination of Thieno[2,3-b]pyridine.
abstract: The first regioselective, mild bromination of thieno[2,3-b]pyridine is described herein. The reaction proceeds with selectivity toward the 4-position (87% isolated yield). Subsequent cross-coupling reactions proceed in excellent yields and demonstrate the potential of 4-bromothieno[2,3-b]pyridine as a building block for use in drug discovery research.
authors.affiliation: AstraZeneca , Alderley Park, Macclesfield, SK10 4TG, United Kingdom.
authors.forename: Simon C C
authors.initials: SC
authors.lastname: Lucas
authors.affiliation: AstraZeneca , Alderley Park, Macclesfield, SK10 4TG, United Kingdom.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Moore
authors.affiliation: AstraZeneca , Alderley Park, Macclesfield, SK10 4TG, United Kingdom.
authors.forename: Craig S
authors.initials: CS
authors.lastname: Donald
authors.affiliation: AstraZeneca , Alderley Park, Macclesfield, SK10 4TG, United Kingdom.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Hawkins