title: Efficacy of Shenzhuo formula on diabetic kidney disease: a retrospective study.
abstract: OBJECTIVE
  To observe the efficacy of a traditional Chinese medicine, Shenzhuo formula, on patients with diabetic kidney disease (DKD).
  
  
  METHODS
  Eighty-eight outpatients with DKD were enrolled. Changes in estimated glomerular filtration rate (eGFR), creatinine clearance, serum creatinine, blood-urea-nitrogen, albuminuria, glycosylated hemoglobin (HbA1C), blood pressure, and lipid profile were measured and analyzed before and after intervention with Shenzhuo formula for 1, 3, 6, 9, 12, and 18 months.
  
  
  RESULTS
  Compared with the baseline amounts, serum creatinine decreased, and eGFR and creatinine clearance increased, significantly after intervention for 1, 3, 6, 9, 12, and 18 months (all P < 0.05). Mean eGFR increased by 2.11 mL/min per 1.73 m²/y after 18-month treatment. Urinary protein at 24 h decreased significantly after 1, 3, 9, and 12 months (P < 0.05). HbA1C decreased significantly (P < 0.05) after 3, 6, 9, 12, and 18 months, and systolic blood pressure decreased significantly (P < 0.05) after 1, 3, and 6 months. Total cholesterol decreased significantly (P < 0.05) after 1, 3, 6, and 18 months. Triglyceride and low-density lipoprotein-cholesterol decreased significantly (P < 0.05) after 1 and 3 months.
  
  
  CONCLUSIONS
  Shenzhuo formula can improve eGFR and possibly slow DKD progression. Shenzhuo formula can also lower HbA1C, lipid levels and blood pressure.
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Tian
authors.forename: Linhua
authors.initials: L
authors.lastname: Zhao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhou
authors.forename: Wenke
authors.initials: W
authors.lastname: Liu
authors.forename: Xinyan
authors.initials: X
authors.lastname: Chen
authors.forename: Fengmei
authors.initials: F
authors.lastname: Lian
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Tong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014280:Triglycerides / Q000378:metabolism; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; D006442:Glycated Hemoglobin; D014280:Triglycerides