title: The Effect of a Community-Based Exercise Program on Inflammation, Metabolic Risk, and Fitness Levels Among Persons Living with HIV/AIDS.
abstract: The human immunodeficiency virus (HIV) pandemic remains a top national health priority. Chronic inflammation may be a critical component in the disease course of HIV as C-reactive protein (CRP) is elevated and associated with increased mortality. This study examined the effect of 3 months of combined aerobic and resistance exercise training among a diverse cohort of HIV-infected men and women. The fixed effect of time for CRP was found to be non-significant (F[1,57.3] = 1.7, p = 0.19). There was a significant fixed effect for time for upper body (F[1,51.6] = 18.1, p < 0.05) and lower body strength (F[1,48.0] = 15.7, p < 0.05) and significant declines in diastolic blood pressure (p = 0.002) and waist circumference (p = 0.027). Though levels of CRP were not impacted after 3 months training, participants demonstrated a significant increase in muscular strength as well as beneficial changes in metabolic risk factors. Future studies should focus on determining the optimal exercise intervention length and mode to reduce inflammation among individuals living with HIV.
authors.affiliation: Department of Kinesiology and Sports Sciences, School of Education and Human Development, University of Miami, Coral Gables, FL, USA. scutrono@med.miami.edu.|Sylvester Comprehensive Cancer, University of Miami, Miller School of Medicine, 1475 NW 12th Avenue, Suite C-021, Miami, FL, 33136, USA. scutrono@med.miami.edu.
authors.forename: Stacy E
authors.initials: SE
authors.lastname: Cutrono
authors.affiliation: Department of Psychiatry & Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL, USA.
authors.forename: John E
authors.initials: JE
authors.lastname: Lewis
authors.affiliation: Department of Kinesiology and Sports Sciences, School of Education and Human Development, University of Miami, Coral Gables, FL, USA.
authors.forename: Arlette
authors.initials: A
authors.lastname: Perry
authors.affiliation: Department of Kinesiology and Sports Sciences, School of Education and Human Development, University of Miami, Coral Gables, FL, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Signorile
authors.affiliation: Department of Psychiatry & Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL, USA.
authors.forename: Eduard
authors.initials: E
authors.lastname: Tiozzo
authors.affiliation: Department of Kinesiology and Sports Sciences, School of Education and Human Development, University of Miami, Coral Gables, FL, USA.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Jacobs
mesh_terms: D000163:Acquired Immunodeficiency Syndrome; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism*; D015444:Exercise; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010809:Physical Fitness; D055070:Resistance Training / Q000379:methods*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein
keywords: Aerobic exercise; C-reactive protein; Human immunodeficiency virus; Inflammation; Metabolic risk; Resistance training