title: Antioxidant activity of low molecular weight alginate produced by thermal treatment.
abstract: By definition, antioxidants are molecules that inhibit the oxidation of other molecules. Therefore, such compounds have very important clinical roles. In this study alginate polymer was depolymerized by heat treatment. The resulting low molecular weight alginates were investigated by UV-visible spectroscopy, Viscometry, Dynamic light scattering and FT-IR spectroscopy techniques. Antioxidant properties of these heat products were studied by ABTS and superoxide radical scavenging assays. Results showed that heating caused breaks in the polymer chain and so generation of low molecular weight alginates. Antioxidant measurements confirmed antioxidant activity of alginate increased upon a decrease in molecular weight. Therefore, low molecular weight alginate produced by heating could be considered as a stronger antioxidant than alginate polymer. These products could be useful for industrial and biomedical applications.
authors.affiliation: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address: zhabibi@ut.ac.ir.
authors.forename: Zahra Habibi
authors.initials: ZH
authors.lastname: Kelishomi
authors.affiliation: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address: goliaei@ibb.ut.ac.ir.
authors.forename: Bahram
authors.initials: B
authors.lastname: Goliaei
authors.affiliation: Polymer Division, School of Chemistry, College of Science, University of Tehran, Tehran, Iran. Electronic address: hmahdavi@khayam.ut.ac.ir.
authors.forename: Hossein
authors.initials: H
authors.lastname: Mahdavi
authors.affiliation: Department of Radiobiology, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: arnikoofar@gmail.com.
authors.forename: Alireza
authors.initials: A
authors.lastname: Nikoofar
authors.affiliation: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address: mahmoodrahimi@ut.ac.ir.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Rahimi
authors.affiliation: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address: Moosavi@ibb.ut.ac.ir.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Moosavi-Movahedi
authors.affiliation: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address: mamashli@ut.ac.ir.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mamashli
authors.affiliation: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address: bhr.bigdeli@ut.ac.ir.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Bigdeli
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008970:Molecular Weight; D010084:Oxidation-Reduction; D058105:Polymerization; D017550:Spectroscopy, Fourier Transform Infrared; D013481:Superoxides
chemical_list: D000464:Alginates; D000975:Antioxidants; D006603:Hexuronic Acids; D013481:Superoxides; D020723:Glucuronic Acid
keywords: ABTS, 2,2′-Azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (PubChem CID: 5815211); Alginate; Alginic acid sodium salt (PubChem CID: 23665711); Antioxidant; Heat depolymerization; Nitro blue tetrazolium (PubChem CID: 9281)