title: Hibiscus rosa sinensis Linn. Petals Modulates Glycogen Metabolism and Glucose Homeostasis Signalling Pathway in Streptozotocin-Induced Experimental Diabetes.
abstract: The prevalence of diabetes mellitus is becoming more and more serious and reaches epidemic proportions worldwide. Scientific research is constantly looking for new agents that could be used as dietary functional ingredients in the fight against diabetes. The objective of the present study was to evaluate the effect of ethyl acetate fraction of Hibiscus rosa sinensis Linn. petals on experimental diabetes at a dose of 25 mg/kg body weight and it was compared with standard anti-diabetic drug metformin. The elevated levels of serum glucose (398.56 ± 35.78) and glycated haemoglobin (12.89 ± 1.89) in diabetic rats were significantly decreased (156.89 ± 14.45 and 6.12 ± 0.49, respectively) by Hibiscus rosa sinensis petals (EHRS) administration. Hepatotoxicity marker enzyme levels in serum were normalized. The fraction supplementation restored the glycogen content by regulating the activities of glycogen metabolizing enzymes. It significantly modulated the expressions of marker genes involved in glucose homeostasis signalling pathway. Histopathological analysis of liver and pancreas supported our findings. The overall effect was comparable with metformin. Hence, our study reveals the role of hibiscus petals for alleviation of diabetes complications, thus it can be propagated as a nutraceutical agent.
authors.affiliation: Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India. sneha.sp88@gmail.com.
authors.forename: Sneha S
authors.initials: SS
authors.lastname: Pillai
authors.affiliation: Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India. minisaraswathy@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Mini
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D035264:Flowers / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006003:Glycogen / Q000378:metabolism; D031584:Hibiscus / Q000737:chemistry*; D006706:Homeostasis / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects; D013311:Streptozocin / Q000009:adverse effects
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin; D006003:Glycogen
keywords: Diabetes mellitus; Glucose homeostasis; Glycogen metabolism; Hibiscus rosa sinensis; Streptozotocin-induced diabetes