title: Clinical End-Points Associated with Mycobacterium tuberculosis and Lung Cancer: Implications into Host-Pathogen Interaction and Coevolution.
abstract: There is a recent emerging theory that suggests a cross-link between pathogens and cancer. In this context, we examined the association between the Mycobacterium tuberculosis (MTB) with its L-forms (MTB-L) and lung cancer. In the present study, we have optimized and applied a highly sensitive assay to detect the presence of MTB and MTB-L in 187 lung cancer samples and 39 samples of other cancer origins. By carefully controlling confounding factors, we have found that 62% of the lung cancer samples are MTB-L positive, while only 5.1% of the other cancer samples are MTB-L positive. Through generalized linear models and random forest models, we have further identified a set of clinical end-points that are strongly associated with MTB-L presence. Our finding provides the basis for future studies to investigate the underlying mechanism linking MTB-L infection to lung cancer development.
authors.affiliation: Central Laboratory, North China Oilfield Hospital of Hebei Medical University, Renqiu, Hebei 062552, China.
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Pathology, North China Oilfield Hospital of Hebei Medical University, Renqiu, Hebei 062552, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Hao
authors.affiliation: Central Laboratory, North China Oilfield Hospital of Hebei Medical University, Renqiu, Hebei 062552, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Cao
authors.affiliation: Central Laboratory, North China Oilfield Hospital of Hebei Medical University, Renqiu, Hebei 062552, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, North China Oilfield Hospital of Hebei Medical University, Renqiu, Hebei 062552, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Oncology Department, North China Oilfield Hospital of Hebei Medical University, Renqiu, Hebei 062552, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Pathology, North China Oilfield Hospital of Hebei Medical University, Renqiu, Hebei 062552, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D054884:Host-Pathogen Interactions / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification* / Q000472:pathogenicity; D014376:Tuberculosis / Q000150:complications / Q000382:microbiology* / Q000401:mortality / Q000473:pathology