title: Mandibular Tissue Engineering: Past, Present, Future.
abstract: Almost 2 decades ago, the senior author's (M.T.J.) first article was with our mentor, Dr Leonard B. Kaban, a review article titled "Distraction Osteogenesis: Past, Present, Future." In 1998, many thought it would be impossible to have a remotely activated, small, curvilinear distractor that could be placed using endoscopic techniques. Currently, a U.S. patent for a curvilinear automated device and endoscopic techniques for minimally invasive access for jaw reconstruction exist. With minimally invasive access for jaw reconstruction, the burden to decrease donor site morbidity has increased. Distraction osteogenesis (DO) is an in vivo form of tissue engineering. The DO technique eliminates a donor site, is less invasive, requires a shorter operative time than usual procedures, and can be used for multiple reconstruction applications. Tissue engineering could further reduce morbidity and cost and increase treatment availability. The purpose of the present report was to review our experience with tissue engineering of bone: the past, present, and our vision for the future. The present report serves as a tribute to our mentor and acknowledges Dr Kaban for his incessant tutelage, guidance, wisdom, and boundless vision.
authors.affiliation: Research Fellow, Skeletal Biology Research Center, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA; and Resident, Department of Oral/Maxillofacial Surgery, Lille University Hospital, Lille, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Konopnicki
authors.affiliation: Associate Professor, Director of Residency Program, Department of Oral/Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA. Electronic address: mtroulis@partners.org.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Troulis
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D008334:Mandible / Q000601:surgery*; D059630:Mesenchymal Stem Cells / Q000502:physiology; D019060:Minimally Invasive Surgical Procedures; D010012:Osteogenesis / Q000502:physiology; D019857:Osteogenesis, Distraction / Q000639:trends; D023822:Tissue Engineering / Q000639:trends*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins