title: Perioperative considerations in adult mitochondrial disease: A case series and a review of 111 cases.
abstract: Mitochondrial disease has been uncommon conditions, still results in death during childhood in many cases. The ideal anesthetic pharmacological management strategy for adult patients with mitochondrial disease is currently unclear. In this study, we presented features of the anesthesia methods employed and the perioperative complications of patients in our institution and in previously published case reports. We report the use of general anesthesia 7 times in 6 adult patients with mitochondrial disease during 2004-2014. All cases were performed with maintained intravenous anesthesia. One case was reintubated on the day after surgery, but the cause of death was not directly related to anesthesia. One hundred and eleven general anesthesia cases in 97 adult patients with mitochondrial disease were described in 83 the literature. Although several severe perioperative complications and deaths have been reported, malignant hyperthermia had not been reported in adult cases, and metabolic disorder called propofol infusion syndrome had also not been reported in adult patients undergone total intravenous anesthesia. Perioperative complications of lactic acidosis were reported more in inhalation anesthesia than intravenous anesthesia. Therefore we recommended intravenous anesthesia rather than inhalation anesthesia for adult mitochondrial disease.
authors.affiliation: Department of Anesthesiology, Yokohama City University Hospital, Yokohama City, Japan. Electronic address: yurinpa88@gmail.com.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Miyamoto
authors.affiliation: Department of Anesthesiology, Yokohama City University Hospital, Yokohama City, Japan. Electronic address: yushukyo@gmail.com.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Miyashita
authors.affiliation: Department of Anesthesiology, Yokohama City University Hospital, Yokohama City, Japan. Electronic address: shunty5323@gmail.com.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Takaki
authors.affiliation: Department of Anesthesiology, Yokohama City University Hospital, Yokohama City, Japan. Electronic address: takigoto@yokohama-cu.ac.jp.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Goto
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood / Q000209:etiology; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000097:blood / Q000209:etiology; D008875:Middle Aged; D028361:Mitochondrial Diseases / Q000601:surgery*; D019990:Perioperative Care / Q000009:adverse effects*
keywords: Adult patients; Anesthetic drugs; Mitochondrial disease