title: Relationship between Type 2 Diabetes and Inflammation Diseases: Cohort Study in Chinese Adults.
abstract: BACKGROUND
  This study aimed to investigate the association of seven common inflammatory diseases with Type 2 diabetes (T2D) in the Chinese Mainland population.
  
  
  METHODS
  Participants were recruited from a great swathe of mainland from 2009 to 2013 for the cohort study. The demographic characteristics between patients with T2D or with inflammatory diseases, including age, sex, smoking status, hypertension etc. were analyzed using the χ(2) test. Cox proportional hazard regression models were used to determine the independent effects of diabetes on the risks of any types of inflammatory diseases in the model and age, sex, hypertension and gout adjusted were used after that.
  
  
  RESULTS
  A total of 39367 participants were enrolled in the study and 1634 (4.2%) subjects with missing information on T2D and the inflammatory diseases were excluded. Compared to those without diabetes, after adjusting for age, sex, hypertension and gout, the incidences of asthma, chronic hepatitis, chronic bronchitis, chronic gastroenteritis, chronic gastritis or ulcer in diabetic patients were independently higher, with odd ratios of 0.235 (95% Confidence Interval [CI], 0.117-0.473), 0.845 (95% CI, 0.731-0.976), 0.585 (95% CI, 0.540-0.634), 0.875 (95% CI, 0.806-0.951), 0.843 (95% CI, 0.787-0.903) respectively. Only inflammatory hemorrhoid did not show any clinical significance.
  
  
  CONCLUSIONS
  There was a decreased incidence of inflammatory diseases in the diabetic patients compared with non-diabetic subjects. Except for inflammatory hemorrhoid, asthma, chronic hepatitis, chronic bronchitis, chronic gastroenteritis, chronic gastritis and ulcer were associated with T2D of Chinese individuals, independently of hypertension and gout, and T2D might reduce the risk of these diseases.
authors.affiliation: Health Science Center, the Chinese PLA General Hospital, FuXing Road 28, Beijing 100853, China.
authors.forename: Yansong
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: The Central Hospital of Xiaogan Health Examination, Tongji Medical College, Huazhong University of Science and Technology, Xiaogan, Hubei, 432000, China.
authors.forename: Guilan
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Health Science Center, the Chinese PLA General Hospital, FuXing Road 28, Beijing 100853, China.
authors.forename: Zhilai
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Health Science Center, the Chinese PLA General Hospital, FuXing Road 28, Beijing 100853, China ; International Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zeng
keywords: Chinese adults; Cohort study; Inflammation diseases; Type 2 diabetes