title: Blood Conservation Strategies and Liver Transplantation Transfusion-Free Techniques Derived from Jehovah's Witness Surgical Cohorts.
abstract: Red blood cell and component transfusions are a frequent and widely accepted accompaniment of surgical procedures. Although the risk of specific disease transmission via allogeneic blood transfusions (ABT) is very low, the occurrence of transfusion related immune modulation (TRIM) still remains a ubiquitous concern. Recent studies have shown that ABT are linked to increased morbidity and mortality across various specialties, with negative outcomes directly correlated to number of transfusions. Blood conservation methods are therefore necessary to reduce ABT. Acute normo-volemic hemodilution (ANH) along with pre-operative blood augmentation and intraoperative cell salvage are blood conservation techniques utilized in tertiary and even quaternary (transplantation) surgery in Jehovah's Witnesses with excellent outcomes. The many hematologic complications such as anemia, thrombocytopenia and coagulopathies that occur with liver transplantation present a significant barrier when trying to avoid ABT. Despite this, living donor liver transplantation (LDLT) has been successfully performed in a transfusion-free environment, providing valuable insight into the possibilities of limiting ABT and its associated risks in all patients.
authors.forename: Mansi
authors.initials: M
authors.lastname: Sheth
authors.forename: Sujit
authors.initials: S
authors.lastname: Kulkarni
authors.forename: Kiran
authors.initials: K
authors.lastname: Dhanireddy
authors.forename: Alexander
authors.initials: A
authors.lastname: Perez
authors.forename: Rick
authors.initials: R
authors.lastname: Selby
mesh_terms: D057668:Bloodless Medical and Surgical Procedures / Q000379:methods*; D006801:Humans; D033221:Jehovah's Witnesses; D016031:Liver Transplantation / Q000379:methods*