title: Multiple roles for TGFβ receptor type II in regulating the pancreatic response in acute pancreatitis.
abstract: In their recent publication in Journal of Pathology, Grabliauskaite and Sapanora and their colleagues in Zurich use a conditional ablation of the TGFβ type II receptor (TBRII) to analyse its specific role in pancreatic epithelial cells in response to a caerulein-induced model of acute pancreatitis. These experiments help to clarify some confusion that has existed in the literature stemming from the use of a dominant-negative transgenic TBRII mouse. The results point to a central role for TBRII in acinar cells in mitigating the overall response of the pancreas to the damage and inflammation of acute pancreatitis.
authors.affiliation: Children's Hospital of Pittsburgh and the Division of Pediatric Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: George K
authors.initials: GK
authors.lastname: Gittes
mesh_terms: D061354:Acinar Cells / Q000473:pathology*; D000818:Animals; D008297:Male; D010179:Pancreas / Q000473:pathology*; D010195:Pancreatitis / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D018125:Receptors, Transforming Growth Factor beta / Q000037:antagonists & inhibitors*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases
keywords: TGFβ signalling; acinar-to-ductal metaplasia; acute pancreatitis; pancreatic fibrosis