title: Common Characteristics of HIV-Neutralizing Antibodies with a Fondness for Sugars.
abstract: Broadly neutralizing antibodies targeting quaternary epitopes on the apex of the HIV-1 envelope spike are an attractive vaccine target, yet engineering immunogens that recapitulate such epitopes has proven difficult. In this issue of Immunity, Andrabi and colleagues (2015) identify an exciting new candidate immunogen that could initiate the production of these types of antibodies through vaccination.
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: amcguire@fredhutch.org.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: McGuire
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Seattle, WA 98109, USA. Electronic address: lstamata@fredhutch.org.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Stamatatos
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D015483:HIV Antibodies / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D014612:Vaccines / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology*; D054299:env Gene Products, Human Immunodeficiency Virus / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D014612:Vaccines; D014759:Viral Envelope Proteins; D054299:env Gene Products, Human Immunodeficiency Virus