title: Parity and Risk of Stroke among Chinese Women: Cross-sectional Evidence from the Dongfeng-Tongji Cohort Study.
abstract: Epidemiological studies have investigated the association between parity and the risk of stroke, but the results have been inconsistent. The objective of this study was to assess the association among middle-aged and older Chinese women. We used data from the Dongfeng-Tongji Cohort Study. In total, 14,277 women were included in the analysis. Participants were classified into four groups according to parity. Stroke cases were self-reported during face-to-face interviews. Multivariable logistic regression models were used to investigate the association between parity and the risk of stroke while controlling for potential confounders. The prevalence of stroke among the study subjects was 2.7% (380 of 14,277). In the fully adjusted model, women who had experienced two, three, or four or more live births had 1.24 times (95% CI, 0.85-1.81), 1.97 times (95% CI, 1.30-2.98) and 1.86 times (95% CI, 1.14-3.03), higher risk of stroke, respectively, compared with women who had experienced one live birth. High parity was associated with an increasing risk of stroke in the present study. Further longitudinal studies are needed to confirm the association and to explore the unclear mechanism underlying the link between parity and stroke risk.
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Shen
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Guiqiang
authors.initials: G
authors.lastname: Xu
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Song
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Siyi
authors.initials: S
authors.lastname: Yang
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Yaohua
authors.initials: Y
authors.lastname: Tian
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Social Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.|Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
authors.forename: Youjie
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D010298:Parity; D011247:Pregnancy; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology*