title: A meta-analysis of P2X7 gene-1513A/C polymorphism and pulmonary tuberculosis susceptibility.
abstract: OBJECTIVE
  A meta-analysis was performed to determine the association between P2X7-1513A/C polymorphism and pulmonary tuberculosis susceptibility.
  
  
  METHODS
  Based on comprehensive searches of the MEDLINE, EMBASE and ISI Web of knowledge, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between P2X7-1513A/C polymorphism and pulmonary tuberculosis susceptibility.
  
  
  RESULTS
  A total of 1916 cases and 2194 controls in 10 studies were pooled together for evaluation of the overall association between P2X7-1513A/C polymorphism and susceptibility of pulmonary tuberculosis. Allele model (A vs. C: p=0.15; OR=0.86, 95% CI=0.69-1.06), homozygous model (AA vs. CC: p=0.22; OR=0.78, 95% CI=0.53-1.16), and heterozygous model (AC vs. CC: p=0.23; OR=0.80, 95% CI=0.56-1.15) did not show decreased risk of developing pulmonary tuberculosis. Similarly, dominant model (AA+AC vs. CC: p=0.19; OR=0.80, 95% CI=0.56-1.12) and recessive model (AA vs. AC+CC: p=0.21; OR=0.85, 95% CI=0.66-1.10) failed to show decreased risk of developing pulmonary tuberculosis. In Indians, allele model (A vs. C: p=0.0006; OR=0.69, 95% CI=0.55-0.85), and recessive model (AA vs. AC+CC: p=0.0003; OR=0.62, 95% CI=0.48-0.80) indicated significant association between P2X7-1513A/C polymorphism and susceptibility to pulmonary tuberculosis.
  
  
  CONCLUSIONS
  Our pooled data suggest a association between P2X7-1513A/C polymorphism and the prevalence of pulmonary tuberculosis among Indian populations.
authors.affiliation: Department of Tuberculosis, Nanjing Chest Hospital, Medicine School of Southeast University, Nanjing 210029, PR China. Electronic address: submanuscript2014@yeah.net.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Ge
authors.affiliation: Department of Respiratory Medicine, Affiliated Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, PR China.
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
mesh_terms: D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D011110:Polymorphism, Genetic; D058486:Receptors, Purinergic P2X7 / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics / Q000276:immunology*
chemical_list: D058486:Receptors, Purinergic P2X7
keywords: Meta-analysis; P2X7; Pulmonary tuberculosis