title: COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae).
abstract: Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 µM (IC50 0.46 µM) compared to the positive control, indomethacin (79.20 %, IC50 0.24 µM).
authors.affiliation: Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia.
authors.forename: Aminu
authors.initials: A
authors.lastname: Muhammad
authors.affiliation: Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia.
authors.forename: Hasnah Mohd
authors.initials: HM
authors.lastname: Sirat
keywords: Bauhinia rufescens; COX-2; phytochemicals