title: [Salvage concomitant chemoradiation therapy for non-metastatic inflammatory breast cancer after chemotherapy failure].
abstract: OBJECTIVE
  To evaluate the surgical possibility following concomitant chemoradiotherapy for inflammatory breast cancer, after unsucessful neoadjuvant chemotherapy.
  
  
  METHODS
  The data from ten patients with inflammatory breast cancer treated between 1996 and 2010 by concomitant chemoradiotherapy after unsucessful neoadjuvant chemotherapy were analysed. All patients had an invasive carcinoma. All patients received a neoadjuvant chemotherapy, including anthracyclin, six patients received taxan and one received trastuzumab. Radiotherapy was delivered to the breast and regional lymph nodes in all patients at a dose of 50Gy; a boost of 20Gy was delivered to one patient. Concomitant chemotherapy was based on weekly cisplatin for six patients, on cisplatin and 5-fluorouracil the first and last weeks of radiotherapy for four patients.
  
  
  RESULTS
  The median follow-up for all patients was 44 months. Mastectomy was performed in nine patients. Two- and 5-year overall survival rates were respectively 70 % and 60 %. Median local recurrence delay was 5 months; six patients died (all from cancer), seven developped metastasis. Grade 1 and 2 epithelite was respectively observed in six and two patients, grade 2 renal toxicity in three patients, grade 2 neutropenia in one patient.
  
  
  CONCLUSIONS
  Concomitant chemoradiotherapy for inflammatory breast cancer after unsucessful neoadjuvant chemotherapy may control the disease in some patients and lead to mastectomy. These results have to be confirmed through a multicentric study with more patients.
authors.affiliation: Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France. Electronic address: aurelie.belliere@cjp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Bellière-Calandry
authors.affiliation: Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: C
authors.initials: C
authors.lastname: Benoît
authors.affiliation: Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: S
authors.initials: S
authors.lastname: Dubois
authors.affiliation: Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: J
authors.initials: J
authors.lastname: Moreau
authors.affiliation: Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Achard
authors.affiliation: Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: G
authors.initials: G
authors.lastname: Loos
authors.affiliation: Département d'oncologie médicale, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Mouret-Reynier
authors.affiliation: Département d'oncologie médicale, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: I
authors.initials: I
authors.lastname: Van Praagh-Doreau
authors.affiliation: Département de chirurgie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: P
authors.initials: P
authors.lastname: Gimbergues
authors.affiliation: Département de chirurgie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: G
authors.initials: G
authors.lastname: Lebouedec
authors.affiliation: Département de chirurgie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: C
authors.initials: C
authors.lastname: Pomel
authors.affiliation: Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: M
authors.initials: M
authors.lastname: Lapeyre
mesh_terms: D000328:Adult; D000368:Aged; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D058922:Inflammatory Breast Neoplasms / Q000188:drug therapy / Q000628:therapy*; D008875:Middle Aged; D016879:Salvage Therapy; D017211:Treatment Failure
keywords: Cancer du sein inflammatoire; Chemopotentialisation; Chimiothérapie concomitante; Chirurgie; Inflammatory breast cancer; Mastectomy; Radiotherapy; Radiothérapie