title: Mucoepidermoid Carcinoma Associated with Osteosarcoma in a True Malignant Mixed Tumor of the Submandibular Region.
abstract: Introduction. True malignant mixed tumor, also known as carcinosarcoma, is a rare tumor of the salivary gland composed of both malignant epithelial and malignant mesenchymal elements. Frequently carcinosarcoma arises in the background of a preexisting pleomorphic adenoma; however, if no evidence of benign mixed tumor is present, the lesion is known as carcinosarcoma "de novo." We reported the first case of true malignant mixed tumor of the submandibular gland composed of high grade mucoepidermoid carcinoma associated with osteosarcoma. Case Presentation. A 69-year-old Caucasian male came to our department complaining of the appearance of an asymptomatic left submandibular neoformation progressively increasing in size over 3 months. We opted for surgical treatment. Histological examination confirmed the diagnosis of carcinosarcoma with the coexistence of high grade mucoepidermoid carcinoma and osteosarcoma. Conclusion. To the best of our knowledge, in the true malignant mixed tumor of the submandibular gland, mucoepidermoid carcinoma associated with osteosarcoma has never been previously reported.
authors.affiliation: Organi di Senso Department, University of "Sapienza", Viale del Policlinico 151, 00161 Rome, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Marcotullio
authors.affiliation: Organi di Senso Department, University of "Sapienza", Viale del Policlinico 151, 00161 Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: de Vincentiis
authors.affiliation: Organi di Senso Department, University of "Sapienza", Viale del Policlinico 151, 00161 Rome, Italy.
authors.forename: Giannicola
authors.initials: G
authors.lastname: Iannella
authors.affiliation: Pathology Department, University of "Sapienza", Viale Regina Elena 324, 00161 Rome, Italy.
authors.forename: Bruna
authors.initials: B
authors.lastname: Cerbelli
authors.affiliation: Organi di Senso Department, University of "Sapienza", Viale del Policlinico 151, 00161 Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Magliulo