title: [Genetic factors of rheumatoid arthritis].
abstract: Rheumatoid arthritis(RA)is one of common autoimmune diseases. As with other complex disorders, recent genome-wide association studies(GWASs)have greatly contributed to our understanding of RA etiology. In this review, the genetic configuration of RA as revealed through GWASs is described. In addition, I discuss the pathologic mechanisms of RA as suggested by the findings of genetic and functional studies of individual RA-associated genes, and the potential use of genetic information for novel drug discovery.
authors.affiliation: Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D008285:Major Histocompatibility Complex