title: Evaluation of renal functions in pediatric liver transplantation.
abstract: AKI is an important complication after LT. As our LT series contains a quite high number of children with ALF unlike published studies, we aimed to determine pre-LT and long-term renal functions in children both with ALF and with CLD. Demographic and disease-related data of 134 transplanted children were evaluated retrospectively. Pre-LT and follow-up GFR and pediatric RIFLE scores were determined. Mean pre-LT GFR was not dependent on the disease presentation or severity of chronic disease. While there was an initial decline until first week of post-LT in CLD children, an increase was observed in ALF. Neither mean GFR nor the pRIFLE on follow-up was different with respect to the type of LT or disease presentation. Mean GFR at first and sixth months were lower in children on cyclosporine compared to tacrolimus (p = 0.001 and p = 0.002, respectively). In conclusion, GFR-time curve was different in children with or without ALF. Type of LT, and severity of the CLD were not risk factors for CKD in any time, but younger age at LT, CLD, and cyclosporine usage were at sixth months of follow-up.
authors.affiliation: Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Mukadder Ayşe
authors.initials: MA
authors.lastname: Selimoğlu
authors.affiliation: Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: İlknur
authors.initials: İ
authors.lastname: Varol
authors.affiliation: Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Hamza
authors.initials: H
authors.lastname: Karabiber
authors.affiliation: Department of Pediatric Nephrology, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Yılmaz
authors.initials: Y
authors.lastname: Tabel
authors.affiliation: Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Meryem
authors.initials: M
authors.lastname: Keçeli
authors.affiliation: Department of General Surgery, Faculty of Medicine, İnönü University, Malatya, Turkey.
authors.forename: Sezai
authors.initials: S
authors.lastname: Yılmaz
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D065095:Calcineurin Inhibitors / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007668:Kidney / Q000502:physiology*; D017093:Liver Failure / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D016559:Tacrolimus / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus
keywords: children; glomerular filtration rate; liver transplantation