title: Combining hard and soft magnetism into a single core-shell nanoparticle to achieve both hyperthermia and image contrast.
abstract: BACKGROUND
  A biocompatible core/shell structured magnetic nanoparticles (MNPs) was developed to mediate simultaneous cancer therapy and imaging.
  
  
  RESULTS
  A 22-nm MNP was first synthesized via magnetically coupling hard (FePt) and soft (Fe3O4) materials to produce high relative energy transfer. Colloidal stability of the FePt@Fe3O4 MNPs was achieved through surface modification with silane-polyethylene glycol (PEG). Intravenous administration of PEG-MNPs into tumor-bearing mice resulted in a sustained particle accumulation in the tumor region, and the tumor burden of treated mice was a third that of the mice in control groups 2 weeks after a local hyperthermia treatment. In vivo magnetic resonance imaging exhibited enhanced T2 contrast in the tumor region.
  
  
  CONCLUSIONS
  This work has demonstrated the feasibility of cancer theranostics with PEG-MNPs.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA.
authors.forename: Maogang
authors.initials: M
authors.lastname: Gong
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
authors.forename: Shuang
authors.initials: S
authors.lastname: Cai
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
authors.forename: Ti
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Nuclear Magnetic Resonance Laboratory, University of Kansas, Lawrence, KS 66045, USA.
authors.forename: Justin T
authors.initials: JT
authors.lastname: Douglas
authors.affiliation: Department of Chemistry, Kansas State University, Manhattan, KS 66506, USA.
authors.forename: Viktor
authors.initials: V
authors.lastname: Chikan
authors.affiliation: The Faculty of Pharmacy, University of Manitoba, Winnipeg, MB R3E OT5, Canada.
authors.forename: Neal M
authors.initials: NM
authors.lastname: Davies
authors.affiliation: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA.|Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors.forename: Phil
authors.initials: P
authors.lastname: Lee
authors.affiliation: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA.|Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors.forename: In-Young
authors.initials: IY
authors.lastname: Choi
authors.affiliation: Department of Mechanical Engineering and Temple Material Institute, Temple University, Philadelphia, PA 19122, USA.
authors.forename: Shenqiang
authors.initials: S
authors.lastname: Ren
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
authors.forename: M Laird
authors.initials: ML
authors.lastname: Forrest
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D007036:Hypothermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D013499:Surface Properties
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D011092:Polyethylene Glycols