title: The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils.
abstract: Chemotaxis, a directional cell migration guided by extracellular chemoattractant gradients, plays an essential role in the recruitment of neutrophils to sites of inflammation. Chemotaxis is mediated by the G protein-coupled receptor (GPCR) signaling pathway. Extracellular stimuli trigger activation of the PLC/PKC/PKD signaling axis, which controls several signaling pathways. Here, we concentrate on the novel functions of PLC/PKC/PKD signaling in GPCR-mediated chemotaxis of neutrophils.
authors.affiliation: Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
authors.forename: Xuehua
authors.initials: X
authors.lastname: Xu
authors.affiliation: Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
authors.forename: Tian
authors.initials: T
authors.lastname: Jin
mesh_terms: D000818:Animals; D002633:Chemotaxis / Q000276:immunology; D006801:Humans; D007527:Isoenzymes; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D043562:Receptors, G-Protein-Coupled; C089212:protein kinase D; D011493:Protein Kinase C; D010738:Type C Phospholipases