title: THE RELEVANCE OF NUTRITIONAL STATUS AND HISTOPATHOLOGICAL FINDINGS ON THE INFECTIOUS PROCESS OF BALB/C MICE INOCULATED WITH Lacazia loboi.
abstract: The aim of this study was to evaluate the effects of the protein-calorie malnutrition in BALB/c isogenic mice infected with Lacazia loboi, employing nutritional and histopathological parameters. Four groups were composed: G1: inoculated with restricted diet, G2: not inoculated with restricted diet, G3: inoculated with regular diet, G4: not inoculated with regular diet. Once malnutrition had been imposed, the animals were inoculated intradermally in the footpad and after four months, were sacrificed for the excision of the footpad, liver and spleen. The infection did not exert great influence on the body weight of the mice. The weight of the liver and spleen showed reduction in the undernourished groups when compared to the nourished groups. The macroscopic lesions, viability index and total number of fungi found in the footpads of the infected mice were increased in G3 when compared to G1. Regarding the histopathological analysis of the footpad, a global cellularity increase in the composition of the granuloma was observed in G3 when compared to G1, with large numbers of macrophages and multinucleated giant cells, discrete numbers of lymphocytes were present in G3 and an increase was observed in G1. The results suggest that there is considerable interaction between Jorge Lobo's disease and nutrition.
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Adriana Sierra Assencio Almeida
authors.initials: AS
authors.lastname: Barbosa
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Suzana Madeira
authors.initials: SM
authors.lastname: Diório
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Silvia Cristina Barboza
authors.initials: SC
authors.lastname: Pedrini
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Adauto José Ferreira
authors.initials: AJ
authors.lastname: Nunes
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Andréa de Faria Fernandes
authors.initials: Ade F
authors.lastname: Belone
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Sônia Maria Uso Ruiz
authors.initials: SM
authors.lastname: Silva
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Beatriz Gomes Carreira
authors.initials: BG
authors.lastname: Sartori
authors.affiliation: Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, Universidade Estadual Paulista, Botucatu, SP, Brasil.
authors.forename: Sueli Aparecida
authors.initials: SA
authors.lastname: Calvi
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Fátima Regina
authors.initials: FR
authors.lastname: Vilani-Moreno
authors.affiliation: Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, Universidade Estadual Paulista, Botucatu, SP, Brasil.
authors.forename: Paulo Câmara Marques
authors.initials: PC
authors.lastname: Pereira
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D060367:Lacazia; D008099:Liver / Q000382:microbiology / Q000473:pathology; D060368:Lobomycosis / Q000150:complications* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009752:Nutritional Status; D009929:Organ Size; D011502:Protein-Energy Malnutrition / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D013154:Spleen / Q000382:microbiology / Q000473:pathology