title: Effect of Octreotide on Colonic Motility in Pediatric Patients With Chronic Recalcitrant Constipation.
abstract: OBJECTIVE
  The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders.
  
  
  METHODS
  This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility.
  
  
  RESULTS
  Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84%) had normal colonic manometry and 2 patients (16%) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.03 ± 1.26 (95% confidence interval [CI] 5.35-6.72) and 5.32 ± 1.66 (95% CI 4.42-6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89 ± 1.37 (95% CI 6.14-7.64) and 6.71 ± 1.47 (95% CI 5.91-7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73 ± 1.32 (95% CI 7.01-8.45) and 7.53 ± 1.38 (95% CI 6.78-8.28), respectively, with P value of 0.8.
  
  
  CONCLUSIONS
  Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.
authors.affiliation: *Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of New Mexico Children's Hospital, Albuquerque †Division of Pediatric Gastroenterology, Hepatology and Nutrition ‡Department of Anesthesia, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis.
authors.forename: Kalyan
authors.initials: K
authors.lastname: Ray Parashette
authors.forename: Shamaila
authors.initials: S
authors.lastname: Waseem
authors.forename: Debra
authors.initials: D
authors.lastname: Horn
authors.forename: Aali
authors.initials: A
authors.lastname: Shah
authors.forename: Joseph
authors.initials: J
authors.lastname: Croffie
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003106:Colon / Q000187:drug effects* / Q000502:physiology; D003108:Colonic Diseases / Q000188:drug therapy / Q000503:physiopathology*; D003248:Constipation / Q000188:drug therapy / Q000503:physiopathology*; D004688:Encopresis / Q000188:drug therapy / Q000503:physiopathology*; D005242:Fecal Incontinence; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D008365:Manometry; D015282:Octreotide / Q000494:pharmacology* / Q000627:therapeutic use; D011446:Prospective Studies
chemical_list: D005765:Gastrointestinal Agents; D015282:Octreotide