title: [INFECTIOUS ENDOCARDITIS IN PREGNANT WOMEN].
abstract: A case of primary infectious endocarditis with the lesion of mitral valve in a pregnant woman is reported The diseases was caused by meticillin-resistant Staphylococcus aureus. Special attention is given to inefficiency of beta-lactame antibiotics against this infection and beneficial effect of daptomycin therapy. This observation confirms literature data about high frequency of thromboembolic complications of S aureus-induced infectious endocarditis due to the production of various coagulases and von Willebrand factor-binding protein by these microorganisms. An increase of coagulation caused by S. aureus is mediated through activation of prothrombin, factor XIII, and fibrin-binding fibronectin. It requires prescription of direct thrombin inhibitor pradax that proved to yield good results in the treatment of our patient. It is concluded that infectious endocarditis in pregnant women is characterized by an atypical clinical picture due to impaired immunity associated with rapid progression of the process after delivery, high frequency of thromboembolic and DIC syndromes.
authors.forename: S R
authors.initials: SR
authors.lastname: Mravyan
authors.forename: I O
authors.initials: IO
authors.lastname: Shuginin
authors.forename: V P
authors.initials: VP
authors.lastname: Pronina
authors.forename: T S
authors.initials: TS
authors.lastname: Budykina
authors.forename: I S
authors.initials: IS
authors.lastname: Mikhailova
authors.forename: V V
authors.initials: VV
authors.lastname: Popov
authors.forename: E N
authors.initials: EN
authors.lastname: Khorikova
authors.forename: E A
authors.initials: EA
authors.lastname: Stepanova
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000991:Antithrombins / Q000008:administration & dosage; D000069604:Dabigatran / Q000008:administration & dosage*; D017576:Daptomycin / Q000008:administration & dosage*; D004452:Echocardiography / Q000379:methods; D004697:Endocarditis, Bacterial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000473:pathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology; D011256:Pregnancy Outcome; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D000991:Antithrombins; D000069604:Dabigatran; D017576:Daptomycin