title: Detecting structural information of scatterers using spatial frequency domain imaging.
abstract: We demonstrate optical phantom experiments on the phase function parameter γ using spatial frequency domain imaging. The incorporation of two different types of scattering particles allows for control of the optical phantoms’ microscopic scattering properties. By laterally structuring areas with either TiO2 or Al2O3 scattering particles, we were able to obtain almost pure subdiffusive scattering contrast in a single optical phantom. Optical parameter mapping was then achieved using an analytical radiative transfer model revealing the microscopic structural contrast on a macroscopic field of view. As part of our study, we explain several correction and referencing techniques for high spatial frequency analysis and experimentally study the sampling depth of the subdiffusive parameter γ.
authors.forename: Nico
authors.initials: N
authors.lastname: Bodenschatz
authors.forename: Philipp
authors.initials: P
authors.lastname: Krauter
authors.forename: Steffen
authors.initials: S
authors.lastname: Nothelfer
authors.forename: Florian
authors.initials: F
authors.lastname: Foschum
authors.forename: Florian
authors.initials: F
authors.lastname: Bergmann
authors.forename: André
authors.initials: A
authors.lastname: Liemert
authors.forename: Alwin
authors.initials: A
authors.lastname: Kienle
mesh_terms: D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008027:Light; D009391:Nephelometry and Turbidimetry / Q000295:instrumentation*; D019047:Phantoms, Imaging; D010783:Photometry / Q000295:instrumentation*; D012031:Refractometry / Q000295:instrumentation*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000295:instrumentation*; D041622:Tomography, Optical / Q000295:instrumentation*