title: Plasma phospholipase, γ-CEHC and antioxidant capacity in fibromyalgia.
abstract: OBJECTIVE
  Recent studies have suggested a possible role of high levels of plasma lysophosphocholines (lysoPCs) in fibromyalgia syndrome (FMS). The aim of this study was to evaluate the content of plasma phospholipases (e.g., Platelet Activating Factor Acetyl Hydrolase [PAF-AH], secretory Phospholipase A2[sPLA2], Total Antioxidant Capacity [TAOC] and 2,7,8-trimethyl-2-(2-carboxyethyl)-6-hydroxy chroman [γ-CEHC]) in FMS patients and their association with clinical status and quality of life.
  
  
  METHODS
  Thirty-six females meeting the 2011 American College of Rheumatology criteria for the classification of FMS and thirty-four healthy females were enrolled for the study. Plasma enzyme levels were quantified using commercial enzyme-linked-immunosorbent-assay (ELISA). In order to assess the disease severity and the functional status of patients, the Fibromyalgia Impact Questionnarie (FIQ) was used.
  
  
  RESULTS
  Higher levels of sPLA2and lower PAF-AH and γ-CEHC were observed in the plasma of FMS patients compared to the controls. A decrease in PAF-AH and TAOC levels were found in severe FMS (S-FMS) compared to mild/slight (MS-FMS) forms.
  
  
  CONCLUSIONS
  The results of the study indicate a possible involvement of phospholipases and γ-CEHC in fibromyalgia syndrome.
authors.affiliation: Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Fais
authors.affiliation: Department of Medical Sciences "Mario Aresu", University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Cacace
authors.affiliation: Department of Biomedical Sciences, University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Atzori
authors.affiliation: Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Era
authors.affiliation: Department of Medical Sciences "Mario Aresu", University of Cagliari, Monserrato, Cagliari, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Ruggiero
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood; D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002839:Chromans / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood; D054497:Phospholipases A2, Secretory / Q000097:blood*; D011422:Propionates / Q000097:blood*; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D002839:Chromans; D011422:Propionates; C107690:2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D054497:Phospholipases A2, Secretory; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C526684:PLA2G7 protein, human
keywords: 
  sPLA
  2
  ; PAF-AH; fibromyalgia; functional status; lysophosphocholines; quality of life; γ-CEHC