title: Synthesis, potential anticonvulsant and antidepressant effects of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives.
abstract: A new series of 2-(5-methyl-2,3-dioxoindolin-1-yl)acetamide derivatives were synthesized and evaluated for their anticonvulsive activity in a pentylenetetrazole (PTZ)-evoked convulsion model and antidepressant activity in the forced swimming test (FST) model. Eleven synthesized compounds were found to be protective against PTZ-induced seizure and showed the anticonvulsant activity. In addition, four of the synthesized compounds (4l, 4m, 4p and 4q) showed potent antidepressant-like activity. Among these compounds, compound 4l was found to have the most potent antidepressant-like activity, and significantly reduced the duration of immobility time at 100 mg/kg dose level when compared to the vehicle control, which is similar to the reference drug fluoxetine.
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan 316022, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Zhen
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan 316022, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan 316022, China.
authors.forename: Shuilian
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan 316022, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
authors.affiliation: Hailisheng Pharmaceutical Co., Lid., Zhoushan 316021, China.
authors.forename: Qinghao
authors.initials: Q
authors.lastname: Jin
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan 316022, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Guan
keywords: 2,3-Dioxoindolin-1-acetamide; Anticonvulsant activity; Antidepressant activity; Pentylenetetrazole; Synthesis