title: Prolonged latency of preterm premature rupture of membranes and risk of cerebral palsy (.).
abstract: OBJECTIVE
  To determine whether prolonged latency after preterm premature rupture of membranes (PPROM) is associated with an increased risk of death or moderate-to-severe cerebral palsy (CP).
  
  
  METHODS
  This secondary analysis of the randomized controlled trial of magnesium sulfate for the prevention of CP evaluated whether the time interval between diagnosis of PPROM and delivery was associated with increased risk for CP. Prolonged latency was defined as an interval of ≥4 weeks, latency time was also categorized by week of latency for further analysis. The primary outcome was death or moderate-to-severe CP at 2 years of age. Logistic regression was used to control for confounders.
  
  
  RESULTS
  In all, 1522 patients with PPROM were analyzed; of whom, 1328 had a <4-week interval and 194 had an interval of ≥4 weeks. In the unadjusted analysis, the primary outcome was less likely in the PPROM ≥4 weeks group 4.1% versus 8.4%, RR: 0.49, 95% CI: 0.24-0.98. After adjusting for possible confounders, there was no statistical difference associated with PPROM latency ≥4 weeks versus <4 weeks for death or moderate-to-severe CP.
  
  
  CONCLUSIONS
  Prolonged exposure to an intrauterine environment of PPROM does not increase risk for CP.
authors.affiliation: a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, Columbia University Medical Center , New York , NY , USA.
authors.forename: Daphnie
authors.initials: D
authors.lastname: Drassinower
authors.affiliation: a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, Columbia University Medical Center , New York , NY , USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Friedman
authors.affiliation: a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, Columbia University Medical Center , New York , NY , USA.
authors.forename: Sarah G
authors.initials: SG
authors.lastname: Običan
authors.affiliation: a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, Columbia University Medical Center , New York , NY , USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Levin
authors.affiliation: a Department of Obstetrics and Gynecology , Division of Maternal-Fetal Medicine, Columbia University Medical Center , New York , NY , USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Gyamfi-Bannerman
mesh_terms: D000328:Adult; D002547:Cerebral Palsy / Q000209:etiology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000401:mortality*; D006801:Humans; D009518:New York / Q000453:epidemiology; D011247:Pregnancy; D013997:Time Factors; D055815:Young Adult
keywords: Cerebral palsy; PPROM; latency; neurodevelopment