title: Expression of p63 in potentially malignant and malignant oral lesions.
abstract: BACKGROUND
  p63, a member of p53 family, known to be expressed in embryonic tissues and basal regenerative layers of many epithelial tissues in the adult, is also expressed in various benign and malignant lesions of body including lesions of oral cavity. To evaluate the expression of p63 and compare the expression qualitatively and quantitatively in normal buccal mucosa, epithelial dysplasia, oral submucous fibrosis (OSMF), and oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  The study material consisted of 45 archival cases which were divided into Group I with 5 cases of normal buccal mucosa, Group II with 15 cases of epithelial dysplasia, and Group III with 10 cases of OSMF and 15 cases of OSCC. Immunohistochemical expression of p63 was assessed by using mean, standard deviation, and analysis of variance.
  
  
  RESULTS
  Overexpression of p63 was seen in epithelial dysplasia, OSMF, and squamous cell carcinoma with an increased suprabasal expression in cases of epithelial dysplasia. The mean labeling index (LI) of p63 was found to be in increasing order from normal oral mucosa (33.75%), OSMF (57.37%), epithelial dysplasia (63.87%) to squamous cell carcinoma (69.76%).
  
  
  CONCLUSIONS
  The results suggest a possible role of p63 in oral carcinogenesis, and an increased LI as well as increased suprabasal expression of this gene in dysplastic lesions may have a potential to be utilized as a marker for premalignancy.
authors.affiliation: Senior Lecturer, Department of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College and Research Center, Ghaziabad, U.P., India.
authors.forename: Anju
authors.initials: A
authors.lastname: Sinha
authors.affiliation: Prof. & Head of Department, Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, King George's Medical University, Lucknow, U.P., India.
authors.forename: Shaleen
authors.initials: S
authors.lastname: Chandra
authors.affiliation: Reader, Department of Oral Pathology & Microbiology, Saraswati Dental College & Hospital, Lucknow, U.P., India.
authors.forename: Vineet
authors.initials: V
authors.lastname: Raj
authors.affiliation: Reader, Department of Pedodontics & Preventive Dentistry, Shree Bankey Bihari Dental College and Research Center, Ghaziabad, U.P., India.
authors.forename: Iram
authors.initials: I
authors.lastname: Zaidi
authors.affiliation: Senior Lecturer, Department of Pedodontics & Preventive Dentistry, Shree Bankey Bihari Dental College and Research Center, Ghaziabad, U.P., India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Saxena
authors.affiliation: Senior Lecturer, Department of Oral Pathology & Microbiology, Daswani Dental College, Kota, Rajasthan, India.
authors.forename: Ruby
authors.initials: R
authors.lastname: Dwivedi
keywords: Epithelial dysplasia; IHC; OSCC; OSMF; p63