title: Acyclic Cucurbit[n]uril Dendrimers.
abstract: The synthesis of acyclic cucurbit[n]uril dendrimers G1-G3 that bear four dendrons on their aromatic sidewalls via thiolate S(N)2 chemistry is reported. G1-G3 are polycationic and can bind to pEGFP plasmid DNA as shown by dynamic light scattering (DLS), gel electrophoresis, and scanning electron microscopy (SEM). The gene delivery ability of G1-G3 is presented.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: David
authors.initials: D
authors.lastname: Sigwalt
authors.affiliation: Department of Cell Biology and Molecular Genetics, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Sarah
authors.initials: S
authors.lastname: Ahlbrand
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Mingming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Brittany
authors.initials: B
authors.lastname: Vinciguerra
authors.affiliation: Department of Cell Biology and Molecular Genetics, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Volker
authors.initials: V
authors.lastname: Briken
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland , College Park, Maryland 20742, United States.
authors.forename: Lyle
authors.initials: L
authors.lastname: Isaacs
mesh_terms: D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D018014:Gene Transfer Techniques; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010957:Plasmids / Q000235:genetics; D011073:Polyamines / Q000737:chemistry; D000071228:Polyelectrolytes; D000099246:Cucurbit(n)urils
chemical_list: D050091:Dendrimers; D047028:Macrocyclic Compounds; D011073:Polyamines; D000071228:Polyelectrolytes; D000099246:Cucurbit(n)urils