title: Between pathways and networks lies context: implications for precision medicine.
abstract: Precision medicine, broadly defined as considering individual variability in genes, environment, and lifestyle for each person in disease prevention and selection of suitable medical intervention, shows strong promise in the treatment of cancer Selecting therapies is complicated by multiple routes to gene dysregulation, which manifest in the individual patient within the many different types of genomic measurements. Additionally, multiple mutations exist in patients, aphenomenon known as oncogenic collaboration, which further complicates the selection of therapy. In this article, we discuss current approaches using biological pathways and networks to unify the many types of OMICs data. We argue that a contextual approach combining cancer pathways and networks could lead to a proper understanding of the biology of this significant disease.
authors.forename: Ted
authors.initials: T
authors.lastname: Laderas
authors.forename: Guanming
authors.initials: G
authors.lastname: Wu
authors.forename: Shannon
authors.initials: S
authors.lastname: McWeeney
mesh_terms: D000818:Animals; D053263:Gene Regulatory Networks; D006801:Humans; D053858:Metabolic Networks and Pathways; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D057285:Precision Medicine / Q000379:methods*