title: Centrosome amplification and clonal evolution in multiple myeloma: Short review.
abstract: Multiple myeloma (MM) is composed of an array of multiple clones, each potentially associated with different clinical behavior. Previous studies focused on clinical implication of centrosome amplification (CA) in MM show contradictory results. It seems that the role of CA as well as CA formation in MM differ from other malignancies. This has brought about a question about the role of CA positive clone which is--is it going to be a more aggressive clone evolutionally arising under pressure of negative conditions or can CA serve as a marker of cell abnormality and lead to cell death and further elimination of this damaged subpopulation? This current review is devoted to the discussion of the existence of MM subclones with centrosome amplification (CA), its evolutionary behaviour within intraclonal heterogeneity as well as its potential impact on the disease progression and MM treatment.
authors.affiliation: Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic.
authors.forename: Elena
authors.initials: E
authors.lastname: Kryukova
authors.affiliation: Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic. Electronic address: f.kryukov@gmail.com.
authors.forename: Fedor
authors.initials: F
authors.lastname: Kryukov
authors.affiliation: Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Hajek
mesh_terms: D017209:Apoptosis / Q000502:physiology; D063646:Carcinogenesis / Q000473:pathology; D049109:Cell Proliferation; D018385:Centrosome / Q000473:pathology*; D060965:Clonal Evolution / Q000502:physiology*; D002999:Clone Cells; D018450:Disease Progression; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000473:pathology*; D013312:Stress, Physiological / Q000502:physiology
keywords: Centrosome amplification; Clonal diversification; Multiple myeloma; Proliferation