title: Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran.
abstract: BACKGROUND
  Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran.
  
  
  METHODS
  Blood samples were collected from 200 CAD patients and 110 healthy individuals with no CAD. The association of two SNPs with CAD was evaluated by PCR and restriction fragment length polymorphism.
  
  
  RESULTS
  Chi-square test showed no association between rs1333040 SNP and CAD (X2: 4.66, df: 2, P=0.09). Also, there was no association between rs1004638 SNP and CAD (X2: 0.27, df: 2, P=0.88).
  
  
  CONCLUSIONS
  No association was observed between rs1333040 and rs1004638 SNPs in the 9P21 region and CAD in Southwest of Iran.
authors.affiliation: Dept. of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Golabgir Khademi
authors.affiliation: Dept. of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Ali Mohammad
authors.initials: AM
authors.lastname: Foroughmand
authors.affiliation: Dept. of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Galehdari
authors.affiliation: Dept. of Medicine, Jondi Shapour University of Medical Science, Ahvaz, Iran.
authors.forename: Saied
authors.initials: S
authors.lastname: Yazdankhah
authors.affiliation: Dept. of Food Hygiene, Faculty of Veterinary medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Pourmahdi Borujeni
authors.affiliation: Dept. of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Shahbazi
authors.affiliation: Dept. of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Dinarvand
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*; D012307:Risk Factors
chemical_list: C561518:CDKN2B antisense RNA, human; D062085:RNA, Long Noncoding
keywords: Coronary artery disease; Genetic association study; Iran; Single nucleotide polymorphisms