title: The Role of the Microbiome in the Relationship of Asthma and Affective Disorders.
abstract: The effect of stress, anxiety and other affective states on inflammatory conditions such as asthma is well documented. Although several immune pathway mechanisms have been proposed and studied, they cannot fully explain the relationship. In this chapter we present a new perspective on asthma development and exacerbation that integrates findings on the role of psychological factors in asthma with the microbiome and the hygiene hypothesis in asthma development.
authors.affiliation: Universidad San Francisco de Quito, Quito, Ecuador. atrueba@usfq.edu.ec.
authors.forename: Ana F
authors.initials: AF
authors.lastname: Trueba
authors.affiliation: Southern Methodist University, Dallas, TX, USA. tritz@smu.edu.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ritz
authors.affiliation: Universidad San Francisco de Quito, Quito, Ecuador. gtrueba@usfq.edu.ec.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Trueba
mesh_terms: D000818:Animals; D001249:Asthma / Q000209:etiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007422:Intestines / Q000382:microbiology; D064307:Microbiota / Q000502:physiology*; D019964:Mood Disorders / Q000276:immunology / Q000382:microbiology*; D010913:Pituitary-Adrenal System / Q000502:physiology; D019936:Probiotics / Q000494:pharmacology
keywords: Anxiety; Asthma; Atopy; Bacteria; Depression; Microbial endocrinology; Stress