title: New strategies for the early detection of pancreatic cancer.
abstract: Pancreatic cancer (PC) remains a deadly disease and early detection through screening is likely to be our best hope to improve survival. Considering the low incidence of PC, population-based screening is not feasible, but is advisable for high-risk patients. Screening individuals at high risk for developing PC leads to the detection of premalignant lesions. High-grade pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm are the targets for early detection of PC. Endoscopic ultrasound (EUS) and magnetic resonance imaging are considered the most accurate techniques for pancreatic imaging; in particular EUS has emerged as a promising imaging test given its potential for tissue sampling to obtain diagnosis and to provide material for molecular profiling of PC. At the moment, screening should be performed within research protocols at experienced centers with a specific clinical and research interest, where a multidisciplinary team of specialists is available.
authors.affiliation: a Pancreato-Biliary Endoscopy and Endosonography Division, San Raffaele Scientific Institute , Vita Salute San Raffaele University , Milan , Italy.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Petrone
authors.affiliation: a Pancreato-Biliary Endoscopy and Endosonography Division, San Raffaele Scientific Institute , Vita Salute San Raffaele University , Milan , Italy.
authors.forename: Paolo Giorgio
authors.initials: PG
authors.lastname: Arcidiacono
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics; D003952:Diagnostic Imaging / Q000379:methods*; D055088:Early Detection of Cancer / Q000379:methods*; D019160:Endosonography; D006801:Humans; D008279:Magnetic Resonance Imaging; D060787:Neoplasm Grading; D009360:Neoplastic Cells, Circulating / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D011237:Predictive Value of Tests
chemical_list: D014408:Biomarkers, Tumor
keywords: Pancreatic cancer; high-risk individuals; intraductal papillary mucinous neoplasm; pancreatic intraepithelial neoplasia; screening