title: The pioneering work of George Mines on cardiac arrhythmias: groundbreaking ideas that remain influential in contemporary cardiac electrophysiology.
abstract: George Mines was a pioneering physiologist who, despite an extremely short period of professional activity and only primitive experimental methodology, succeeded in formulating concepts that continue to be of great influence today. Here, we review some of his most important discoveries and their impact on contemporary concepts and clinical practice. Mines' greatest contribution was his conceptualization and characterization of circus movement reentry. His observations and ideas about the basis for cardiac reentrant activity underlie how we understand and manage a wide range of important clinical rhythm disturbances today. The notions he introduced regarding the influence of premature extrastimuli on reentry (termination, resetting and entrainment) are central to contemporary assessment of arrhythmia mechanisms in clinical electrophysiology laboratories and modern device therapy of cardiac tachyarrhythmias. Refinements of his model of reentry have led to sophisticated biophysical theories of the mechanisms underlying cardiac fibrillation. His seminal observations on the influence of electrolyte derangements and autonomic tone on the heart are relevant to our understanding of the physiology and pharmacology of arrhythmias caused by cardiac pathology. In this era of advanced technology, it is important to appreciate that ideas of lasting impact come from great minds and do not necessarily require great tools.
authors.affiliation: Research Center, Montreal Heart Institute, Montreal, Canada.|Department of Physiology, Université de Montréal, Montreal, Canada.|Department of Medicine, Université de Montréal, Montreal, Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Aguilar
authors.affiliation: Research Center, Montreal Heart Institute, Montreal, Canada.|Department of Medicine, Université de Montréal, Montreal, Canada.|Department of Medicine, McGill University, Montreal, Canada.|Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.|Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.
authors.forename: Stanley
authors.initials: S
authors.lastname: Nattel
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D004594:Electrophysiology; D006321:Heart / Q000503:physiopathology*; D006801:Humans