title: Critical appraisal of Timothy grass pollen extract GRAZAX in the management of allergic rhinitis.
abstract: Allergic rhinitis is one of the most common diseases of adult and pediatric age, associated with grass pollen (GP) allergy in >50% cases, with a consistent impact on quality of life of affected patients. A grass allergen tablet, containing standardized extract derived from Timothy grass (Phleum pratense) pollen and ~15 μg major allergen P. pratense (rPhl p 5), may be the future of allergen-specific immunotherapy (IT) for GP allergy. The aim of this review was to critically evaluate the role of Timothy GP extract IT for the management of allergic rhinitis. For this purpose, we have tried to analyze potential mechanisms of action at the basis of Timothy GP extract, we have reviewed efficacy studies to establish potential benefits and clinical response, and we have also evaluated safety and tolerability profiles and patient focus perspective, such as quality of life, satisfaction and acceptability, and compliance to this IT.
authors.affiliation: Department of Pediatrics, University of Chieti, Chieti, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Scaparrotta
authors.affiliation: Department of Pediatrics, University of Chieti, Chieti, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Attanasi
authors.affiliation: Department of Pediatrics, University of Chieti, Chieti, Italy.
authors.forename: Marianna I
authors.initials: MI
authors.lastname: Petrosino
authors.affiliation: Department of Pediatrics, University of Chieti, Chieti, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Di Filippo
authors.affiliation: Department of Pediatrics, University of Chieti, Chieti, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Di Pillo
authors.affiliation: Department of Pediatrics, University of Chieti, Chieti, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiarelli
mesh_terms: D000328:Adult; D002648:Child; D003888:Desensitization, Immunologic / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D031784:Phleum / Q000276:immunology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D011058:Pollen; D011788:Quality of Life; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*
chemical_list: C551013:Grazax; D010936:Plant Extracts
keywords: Grazax; Timothy grass pollen extract; allergic rhinitis; compliance; efficacy; safety