title: The concept of bio-corona in modulating the toxicity of engineered nanomaterials (ENM).
abstract: Besides the wide use of engineered nanomaterials (ENM) in technical products, their application spectrum in biotechnology and biomedicine is steadily increasing. In complex physiological environments the physico-chemical properties and the behavior of nanoparticles (NPs) are challenging to characterize. Biomolecules rapidly adsorb to the nanomaterial, leading to the formation of the protein/biomolecule corona, which critically affects the nanomaterials' (patho)biological and technical identities. This formation can trigger an immune response and affect nanoparticles' toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the (protein)corona-nanoparticle interaction and discuss how the corona modulates both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers.
authors.affiliation: Department of Nanobiomedicine/ENT, University Medical Center of Mainz, Langenbeckstr. 1, 55101 Mainz, Germany.
authors.forename: Dana
authors.initials: D
authors.lastname: Westmeier
authors.affiliation: Department of Nanobiomedicine/ENT, University Medical Center of Mainz, Langenbeckstr. 1, 55101 Mainz, Germany.
authors.forename: Roland H
authors.initials: RH
authors.lastname: Stauber
authors.affiliation: Department of Nanobiomedicine/ENT, University Medical Center of Mainz, Langenbeckstr. 1, 55101 Mainz, Germany. Electronic address: docter@uni-mainz.de.
authors.forename: Dominic
authors.initials: D
authors.lastname: Docter
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity*; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D014018:Tissue Distribution / Q000187:drug effects / Q000502:physiology
chemical_list: D001672:Biocompatible Materials
keywords: Corona; Nanomedicine; Nanotoxicology