title: α-Glucosidase and 15-Lipoxygenase Inhibitory Activities of Phytochemicals from Calophyllum symingtonianum.
abstract: A phytochemical investigation of the crude extracts of the bark and leaves of Calophyllum symingtonianum has resulted in the isolation of inophyllum D, inophyllum H, calanone, isocordato-oblongic acid, amentoflavone, carpachromene and lupenone. Their chemical structures were elucidated and confirmed by spectroscopic analysis. All flavonoids and coumarins showed significant α-glucosidase inhibitory activity, while amentoflavone gave a positive result against 15-lipoxygenase inhibition.
authors.forename: Nurul Iman
authors.initials: NI
authors.lastname: Aminudin
authors.forename: Farediah
authors.initials: F
authors.lastname: Ahmad
authors.forename: Muhammad
authors.initials: M
authors.lastname: Taher
authors.forename: Razauden Mohamed
authors.initials: RM
authors.lastname: Zulkifli
mesh_terms: D001093:Arachidonate 15-Lipoxygenase / Q000378:metabolism*; D029759:Calophyllum / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D064209:Phytochemicals / Q000737:chemistry / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D016859:Lipoxygenase Inhibitors; D064209:Phytochemicals; D001093:Arachidonate 15-Lipoxygenase; D000520:alpha-Glucosidases