title: Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor.
abstract: In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. These effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body), kappa opioid receptor antagonist. These findings suggest that kappa opioid receptor is involved in the effect of GJG on the bortezomib-induced mechanical allodynia.
authors.affiliation: Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Higuchi
authors.affiliation: Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ushio
authors.affiliation: Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Kawashiri
authors.affiliation: Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan. Electronic address: n-egashi@pharm.med.kyushu-u.ac.jp.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Egashira
mesh_terms: D031841:Aconitum; D000818:Animals; D000069286:Bortezomib / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000494:pharmacology*; D006930:Hyperalgesia / Q000139:chemically induced* / Q000188:drug therapy*; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D008517:Phytotherapy; D017207:Rats, Sprague-Dawley; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors / Q000502:physiology*; D014147:Tramadol / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D017473:Receptors, Opioid, kappa; C119642:gosha-jinki-gan; C051844:norbinaltorphimine; D014147:Tramadol; D009271:Naltrexone; D000069286:Bortezomib
keywords: Bortezomib; Goshajinkigan; Peripheral neuropathy