title: Food and Natural Materials Target Mechanisms to Effectively Regulate Allergic Responses.
abstract: An immune hypersensitivity disorder called allergy is caused by diverse allergens entering the body via skin contact, injection, ingestion, and/or inhalation. These allergic responses may develop into allergic disorders, including inflammations such as atopic dermatitis, asthma, anaphylaxis, food allergies, and allergic rhinitis. Several drugs have been developed to treat these allergic disorders; however, long-term intake of these drugs could have adverse effects. As an alternative to these medicines, food and natural materials that ameliorate allergic disorder symptoms without producing any side effects can be consumed. Food and natural materials can effectively regulate successive allergic responses in an allergic chain-reaction mechanism in the following ways: [1] Inhibition of allergen permeation via paracellular diffusion into epithelial cells, [2] suppression of type 2 T-helper (Th) cell-related cytokine production by regulating Th1/Th2 balance, [3] inhibition of pathogenic effector CD4(+) T cell differentiation by inducing regulatory T cells (Treg), and [4] inhibition of degranulation in mast cells. The immunomodulatory effects of food and natural materials on each target mechanism were scientifically verified and shown to alleviate allergic disorder symptoms. Furthermore, consumption of certain food and natural materials such as fenugreek, skullcap, chitin/chitosan, and cheonggukjang as anti-allergics have merits such as safety (no adverse side effects), multiple suppressive effects (as a mixture would contain various components that are active against allergic responses), and ease of consumption when required. These merits and anti-allergic properties of food and natural materials help control various allergic disorders.
authors.affiliation: Division of Creative Food Science for Health, Korea Food Research Institute.
authors.forename: Hee Soon
authors.initials: HS
authors.lastname: Shin
authors.forename: Dong-Hwa
authors.initials: DH
authors.lastname: Shon
mesh_terms: D000485:Allergens / Q000378:metabolism*; D002686:Chitin / Q000494:pharmacology / Q000627:therapeutic use; D004032:Diet; D005502:Food; D006801:Humans; D006967:Hypersensitivity / Q000178:diet therapy / Q000188:drug therapy* / Q000276:immunology; D008407:Mast Cells / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010944:Plants; D017747:Seafood; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D000485:Allergens; D010936:Plant Extracts; D002686:Chitin