title: NHC-Ag(I)-Catalyzed Three-Component 1,3-Dipolar Cycloaddition To Provide Polysubstituted Dihydro-/Tetrahydrofurans.
abstract: A new method was developed to synthesize polyfunctionalized dihydrofuran and tetrahydrofuran derivatives from the three-component [2 + 2 + 1] cycloaddition of the diazoesters with aryl/alkenyl aldehydes and alkyne/olefin dipolarophiles by using a Ag(I) N-heterocyclic carbene complex as the catalyst. A carbonyl ylide intermediate was generated, which undertook an endo-type 1,3-dipolar cycloaddition to provide the desired dihydro-/tetrahydrofurans in high regio- and diastereoselectivities by using α-aryl or α-alkenyl diazoesters.
authors.affiliation: Department of Chemistry, Renmin University of China , Beijing 100872, China.|College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities , Chengdu 610041, China.
authors.forename: Yi-Fei
authors.initials: YF
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Renmin University of China , Beijing 100872, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Renmin University of China , Beijing 100872, China.
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Shi
authors.affiliation: College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities , Chengdu 610041, China.
authors.forename: Bai-Ling
authors.initials: BL
authors.lastname: Chen
authors.affiliation: College of Chemistry & Environment Protection Engineering, Southwest University for Nationalities , Chengdu 610041, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, Renmin University of China , Beijing 100872, China.
authors.forename: Zili
authors.initials: Z
authors.lastname: Chen