title: Combined use of the Ilizarov method, concentrated bone marrow aspirate (cBMA), and platelet-rich plasma (PRP) to expedite healing of bimalleolar fractures.
abstract: Distal tibial and fibular fractures, particularly in patients with comorbidities, heal slowly and have a high incidence of postoperative nonunion and infection. Autologous concentrated bone marrow aspirate (cBMA) and platelet-rich plasma (PRP) increase osteogenic potential of demineralized bone matrix (DBM). The purpose of this case series was to evaluate the efficacy of cBMA, PRP, DBM in conjunction with the Ilizarov fixator as compared to DBM and the Ilizarov fixator alone in expediting fracture healing. Ten patients (mean age 52.9 years) were in the cBMA Group, and 10 patients (mean age 54 years) were in the Control Group. Comorbidities included diabetes, obesity, smoking, and renal disease. Radiographs showed a significant difference in the rate of complete healing in the cBMA Group at 16 ± 1.6 weeks post-surgery as compared to 24 ± 1.3 weeks in the Control Group (P < 0.001). No differences were observed between groups in infection rate or nonunions. We conclude that the Ilizarov fixator combined with DBM, cBMA, and PRP expedites fracture healing of the distal tibia and fibula in patients with significant comorbidities.
authors.affiliation: Department of Surgery, Presence Saint Joseph Hospital, 2900 N Lake Shore Dr., Chicago, IL, 60657, USA. erodriguez@cfaas.com.
authors.forename: Edgardo R
authors.initials: ER
authors.lastname: Rodriguez-Collazo
authors.affiliation: Arteriocyte Medical Systems, 45 South St., Suite 3, Hopkinton, MA, 01748, USA. urso.maria@gmail.com.
authors.forename: Maria L
authors.identifier: http://orcid.org/0000-0001-8906-4673
authors.initials: ML
authors.lastname: Urso
keywords: Comorbidities; Fibula; Fracture; Mesenchymal stem cell; Nonunion; Tibia