title: NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population.
abstract: Natural resistance-associated macrophage protein (Nramp1) and the vitamin D receptor (VDR) are central components of the innate and adaptive immunity against Mycobacterium tuberculosis, and associations between susceptibility to tuberculosis and polymorphisms in the genes NRAMP and VDR have been sought in geographically diverse populations. We investigated associations of NRAMP1 and VDR gene polymorphisms with susceptibility to TB in the Venezuelan population. The results suggest the absence of any association between VDR variants FokI, ApaI, and TaqI and susceptibility to tuberculosis. In contrast, the NRAMP1 3'UTR variants were associated with susceptibility to M. tuberculosis infection, as seen in the comparisons between TST+ and TST- controls, and also with progression to TB disease, as shown in the comparisons between TB patients and TST+ controls. This study confirms the previously described association of the NRAMP1 3'UTR polymorphism with M. tuberculosis infection and disease progression.
authors.affiliation: Laboratorio de Fisiopatología, Centro de Medicina Experimental "Miguel Layrisse", Instituto Venezolano de Investigaciones Científicas, Kilómetro 11 Carretera Panamericana, Apartado 21827, Caracas 1020A, Distrito Capital, Venezuela.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Fernández-Mestre
authors.affiliation: Laboratorio de Fisiopatología, Centro de Medicina Experimental "Miguel Layrisse", Instituto Venezolano de Investigaciones Científicas, Kilómetro 11 Carretera Panamericana, Apartado 21827, Caracas 1020A, Distrito Capital, Venezuela.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Villasmil
authors.affiliation: Laboratorio de Genética Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Kilómetro 11 Carretera Panamericana, Apartado 21827, Caracas 1020A, Distrito Capital, Venezuela.
authors.forename: Howard
authors.initials: H
authors.lastname: Takiff
authors.affiliation: Unidad de Tórax, Hospital Dr. José Ignacio Baldó "El Algodonal", Avenida Intercomunal de Antímano, La Yaguara, Apartado 1000, Caracas 1020A, Distrito Capital, Venezuela.
authors.forename: Zhenia Fuentes
authors.initials: ZF
authors.lastname: Alcalá
mesh_terms: D020413:3' Untranslated Regions; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D014376:Tuberculosis / Q000235:genetics*; D000099173:Natural Resistance-associated Macrophage Protein 1
chemical_list: D020413:3' Untranslated Regions; D027682:Cation Transport Proteins; D018167:Receptors, Calcitriol; D000099173:Natural Resistance-associated Macrophage Protein 1; C579457:VDR protein, human