title: What is the evidence for the role of TRP channels in inflammatory and immune cells?
abstract: A complex network of many interacting mechanisms orchestrates immune and inflammatory responses. Among these, the cation channels of the transient receptor potential (TRP) family expressed by resident tissue cells, inflammatory and immune cells and distinct subsets of primary sensory neurons, have emerged as a novel and interrelated system to detect and respond to harmful agents. TRP channels, by means of their direct effect on the intracellular levels of cations and/or through the indirect modulation of a large series of intracellular pathways, orchestrate a range of cellular processes, such as cytokine production, cell differentiation and cytotoxicity. The contribution of TRP channels to the transition of inflammation and immune responses from a defensive early response to a chronic and pathological condition is also emerging as a possible underlying mechanism in various diseases. This review discusses the roles of TRP channels in inflammatory and immune cell function and provides an overview of the effects of inflammatory and immune TRP channels on the pathogenesis of human diseases.
authors.affiliation: Clinical Pharmacology and Oncology Unit, Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Parenti
authors.affiliation: Clinical Pharmacology and Oncology Unit, Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: F
authors.initials: F
authors.lastname: De Logu
authors.affiliation: Clinical Pharmacology and Oncology Unit, Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Geppetti
authors.affiliation: Clinical Pharmacology and Oncology Unit, Department of Health Sciences, University of Florence, Florence, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Benemei
mesh_terms: D000818:Animals; D006801:Humans; D007107:Immune System / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: D050051:Transient Receptor Potential Channels