title: NF-κB in inflammation and renal diseases.
abstract: Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as inactive complexes via physical association with inhibitory proteins termed IκBs. In response to immune and stress stimuli, NF-κB members become activated via two major signaling pathways, the canonical and noncanonical pathways, and move to the nucleus to exert transcriptional functions. NF-κB is vital for normal immune responses against infections, but deregulated NF-κB activation is a major cause of inflammatory diseases. Accumulated studies suggest the involvement of NF-κB in the pathogenesis of renal inflammation caused by infection, injury, or autoimmune factors. In this review, we discuss the current understanding regarding the activation and function of NF-κB in different types of kidney diseases.
authors.affiliation: Department of Nephrology, Affiliated Hospital of Hebei University, No. 213 Yuhuadonglu, Baoding, 071000 China.
authors.forename: Haisong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, TX 77030 USA ; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030 USA.
authors.forename: Shao-Cong
authors.initials: SC
authors.lastname: Sun
keywords: IgA nephropathy; Inflammation; NF-κB; Nephritis; Renal diseases