title: SBR-Blood: systems biology repository for hematopoietic cells.
abstract: Extensive research into hematopoiesis (the development of blood cells) over several decades has generated large sets of expression and epigenetic profiles in multiple human and mouse blood cell types. However, there is no single location to analyze how gene regulatory processes lead to different mature blood cells. We have developed a new database framework called hematopoietic Systems Biology Repository (SBR-Blood), available online at http://sbrblood.nhgri.nih.gov, which allows user-initiated analyses for cell type correlations or gene-specific behavior during differentiation using publicly available datasets for array- and sequencing-based platforms from mouse hematopoietic cells. SBR-Blood organizes information by both cell identity and by hematopoietic lineage. The validity and usability of SBR-Blood has been established through the reproduction of workflows relevant to expression data, DNA methylation, histone modifications and transcription factor occupancy profiles.
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA lichtenbergj@mail.nih.gov.
authors.forename: Jens
authors.identifier: http://orcid.org/0000-0002-0023-4937
authors.initials: J
authors.lastname: Lichtenberg
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Elisabeth F
authors.initials: EF
authors.lastname: Heuston
authors.affiliation: Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
authors.forename: Tejaswini
authors.initials: T
authors.lastname: Mishra
authors.affiliation: Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Keller
authors.affiliation: Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
authors.forename: Ross C
authors.initials: RC
authors.lastname: Hardison
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Bodine
mesh_terms: D000818:Animals; D019175:DNA Methylation; D030541:Databases, Genetic; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D006410:Hematopoiesis / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D051379:Mice; D049490:Systems Biology