title: Lignans from the roots of Acorus tatarinowii Schott ameliorate β amyloid-induced toxicity in transgenic Caenorhabditis elegans.
abstract: A novel tetralignan, tatarinan T (1) with the rare C8-C7' linkage pattern, along with a known monolignan (2) were isolated from the roots of Acorus tatarinowii Schott. Their chemical structures were elucidated on the basis of NMR and X-ray diffraction analysis. We evaluated the protective effects of two rare lignans against β-amyloid toxicity by using CL4176 transgenic C. elegans model for the first time, and found that they significantly delayed paralysis of worms at the concentration of 100 μM. Compound 2 exhibited the more potential protective effect against β-amyloid toxicity, its value of PT50 extended up to 62.3% at 100 μM compared with control, especially, it still has 30.8% extension at 10 μM.
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai, 200092, PR China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Luo
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai, 200092, PR China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai, 200092, PR China.
authors.forename: Xin-Yan
authors.initials: XY
authors.lastname: Chen
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai, 200092, PR China.
authors.forename: Meng-Lu
authors.initials: ML
authors.lastname: Sun
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai, 200092, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai, 200092, PR China. Electronic address: hbwang@tongji.edu.cn.
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Wang
mesh_terms: D029023:Acorus / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000633:toxicity; D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000235:genetics; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal; D017705:Lignans; D010936:Plant Extracts; C000607125:tatarinan T
keywords: Acorus tatarinowii; C. elegans; Lignan; Paralysis