title: Impaired response of regulator of Gαq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats.
abstract: Dahl salt-sensitive (Dahl S) rats are prone to salt-dependent hypertension with severe organ damage, including stroke, cardiac failure and renal insufficiency. The mechanism for this susceptibility to kidney injury has not been elucidated. The present study proposed that an upregulation of intracellular signaling of angiotensin II (Ang-II) is responsible for the susceptibility to hypertensive kidney injury in Dahl S rats. Spontaneously hypertensive rats exhibited higher systolic blood pressure (SBP) and lower kidney damage than Dahl S rats fed a high-salt diet for 2 weeks. Ang-II infusion for 4 weeks significantly increased SBP in Dahl S and Dahl salt-resistant (Dahl R) rats fed a low-salt diet. The increase in SBP in Dahl S rats was associated with significant kidney injury with greater glomerular sclerosis (P<0.001). The expression of regulatory protein of Gαq signaling-2 (RGS2) mRNA in the aortic walls in response to Ang-II infusion was lower in Dahl S than Dahl R rats (P<0.05). Ang-II significantly increased RGS2 mRNA in the aorta in Dahl R rats, but the response was apparently blunted in Dahl S rats. These results suggest that Dahl S rats exhibit a blunted RGS2 response to Ang-II, and this blunted response may be partially responsible for the susceptibility to renal injury in Dahl S rats.
authors.affiliation: Department of Cardiology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Yaqiong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Institute of Medical Science, St Marianna University School of Medicine, Miyamae-ku, Kawasaki, Japan.
authors.forename: Etsu
authors.initials: E
authors.lastname: Suzuki
authors.affiliation: International Clinical Research Center, St Anne's University Hospital and Masaryk University, Brno, Czech Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
authors.affiliation: International Clinical Research Center, St Anne's University Hospital and Masaryk University, Brno, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Soucek
authors.affiliation: Department of Food and Nutrition, Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women's University, Tokyo, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Uehara
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D006973:Hypertension / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D020710:RGS Proteins / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D020303:Rats, Inbred Dahl; D012982:Sodium, Dietary
chemical_list: D020710:RGS Proteins; C514563:RGS2 protein, rat; D012982:Sodium, Dietary; D000804:Angiotensin II