title: Sulfotanone, a new alkyl sulfonic acid derivative from Streptomyces sp. IFM 11694 with TRAIL resistance-overcoming activity.
abstract: One new alkyl sulfonic acid derivative, sulfotanone (1), and the known panosialin wA (2) were isolated from the methanolic extract of mycelium of Streptomyces sp. 11694. The structure of the new compound (1) was established by a combination of spectroscopic techniques, including HRESIMS, IR, 1D and 2D NMR measurements. Compound 1 (40 µM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistance in human gastric adenocarcinoma cell lines.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.|Chemistry Department, Faculty of Science, Helwan University, Cairo, 11795, Egypt.
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Abdelfattah
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishikawa
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
authors.forename: Utpal K
authors.initials: UK
authors.lastname: Karmakar
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. mish@chiba-u.jp.
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001555:Benzene Derivatives / Q000302:isolation & purification; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004351:Drug Resistance / Q000187:drug effects*; D004357:Drug Synergism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013274:Stomach Neoplasms / Q000188:drug therapy*; D013302:Streptomyces / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D001688:Biological Products; D013451:Sulfonic Acids; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; C000611403:sulfotanone; C003039:panosialin
keywords: Actinomycetes; Spectroscopy; Sulfonic acid; TRAIL