title: The story of HCC in NAFLD: from epidemiology, across pathogenesis, to prevention and treatment.
abstract: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. An increasing number of reports describe HCC in the setting of obesity and diabetes, two major risk factors for non-alcoholic fatty liver disease (NAFLD). The increasing incidence of these conditions and the emerging evidence of HCC in non-cirrhotic NAFLD prioritize a better understanding of NAFLD-related HCC epidemiology and pathogenesis in order to target screening policies and develop preventive-therapeutic strategies. In this review, we focus on the epidemiological impact of this condition, suggesting a possible link between HCC in cryptogenic cirrhosis and NAFLD. Furthermore, we analyse the suggested pathogenic mechanisms and the possible preventive-therapeutic strategies.
authors.affiliation: Hepatology, Department of Clinical Research, University of Bern, Bern, Switzerland.|University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland.
authors.forename: Cristina
authors.initials: C
authors.lastname: Margini
authors.affiliation: Hepatology, Department of Clinical Research, University of Bern, Bern, Switzerland.|University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland.
authors.forename: Jean F
authors.initials: JF
authors.lastname: Dufour
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D015897:Comorbidity; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008113:Liver Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
keywords: HCC; NAFLD; diabetes; obesity