title: [Sudden deafness as the initial manifestation of chronic myelogenous leukemia: case report].
abstract: To study the pathogenesis of hearing loss in chronic myelogenous leukemia (CML). To report one case with CML whose first sign was sudden unilateral hearing loss. Sudden hearing loss in CML was presented with dramatic high white blood cell count in peripheral blood. Some cases of sudden hearing loss in CML may be improved or even cured by leukapheresis and intrathecal chemotherapy. The proposed pathogenesis for deafness in leukemia is due to hyperleukocytosis, hyperviscosity syndrome, leukemic infiltration and the inner ear hemorrhage. In treatment, clinicians should quickly reduce the number of white blood cells to lighten the tumor burden. Intrathecal injection of MTX and plasmapheresis is commonly used.
authors.forename: Yandi
authors.initials: Y
authors.lastname: Chen
authors.forename: Lifeng
authors.initials: L
authors.lastname: An
authors.forename: Guanghua
authors.initials: G
authors.lastname: Jin
mesh_terms: D007758:Ear, Inner / Q000473:pathology; D003639:Hearing Loss, Sudden / Q000209:etiology*; D046088:Hearing Loss, Unilateral / Q000209:etiology*; D006470:Hemorrhage / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D007958:Leukocyte Count