title: World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction.
abstract: The aim of this paper was to perform a systematic review of the pathogenesis of medication-induced salivary gland dysfunction (MISGD). Review of the identified papers was based on the standards regarding the methodology for systematic reviews set forth by the World Workshop on Oral Medicine IV and the PRISMA statement. Eligible papers were assessed for both the degree and strength of relevance to the pathogenesis of MISGD as well as on the appropriateness of the study design and sample size. A total of 99 papers were retained for the final analysis. MISGD in human studies was generally reported as xerostomia (the sensation of oral dryness) without measurements of salivary secretion rate. Medications may act on the central nervous system (CNS) and/or at the neuroglandular junction on muscarinic, α-and β-adrenergic receptors and certain peptidergic receptors. The types of medications that were most commonly implicated for inducing salivary gland dysfunction were those acting on the nervous, cardiovascular, genitourinary, musculoskeletal, respiratory, and alimentary systems. Although many medications may affect the salivary flow rate and composition, most of the studies considered only xerostomia. Thus, further human studies are necessary to improve our understanding of the association between MISGD and the underlying pathophysiology.
authors.affiliation: Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Villa
authors.affiliation: Tel-Aviv Sourasky Medical Center and Saliwell Ltd., Harutzim, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Wolff
authors.affiliation: Department of Oral Biology, UNMC College of Dentistry, Lincoln, NE, USA.
authors.forename: N
authors.initials: N
authors.lastname: Narayana
authors.affiliation: Department of Oral Biology, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Dawes
authors.affiliation: The Hebrew University, Jerusalem, Israel.
authors.forename: D J
authors.initials: DJ
authors.lastname: Aframian
authors.affiliation: Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: A M
authors.initials: AM
authors.lastname: Lynge Pedersen
authors.affiliation: University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Vissink
authors.affiliation: Faculty of Dental Medicine, University of Medicine, Tirana, Albania.|Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Aliko
authors.affiliation: McGill University, Montreal, QC, Canada.
authors.forename: Y W
authors.initials: YW
authors.lastname: Sia
authors.affiliation: DAPMRV Dental College, Bangalore, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Joshi
authors.affiliation: New York University College of Dentistry, New York, NY, USA.
authors.forename: R
authors.initials: R
authors.lastname: McGowan
authors.affiliation: Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: S B
authors.initials: SB
authors.lastname: Jensen
authors.affiliation: New York University College of Dentistry, New York, NY, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Kerr
authors.affiliation: Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Ekström
authors.affiliation: Division of Mucosal & Salivary Biology, Dental Institute, King's College London, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Proctor
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D019242:Oral Medicine / Q000379:methods; D012466:Salivary Gland Diseases / Q000139:chemically induced* / Q000473:pathology; D012469:Salivary Glands / Q000187:drug effects* / Q000473:pathology
keywords: pathogenesis; physiology; saliva; salivary glands