title: Strategies for functional bioscaffold-based skeletal muscle reconstruction.
abstract: Tissue engineering and regenerative medicine-based strategies for the reconstruction of functional skeletal muscle tissue have included cellular and acellular approaches. The use of acellular biologic scaffold material as a treatment for volumetric muscle loss (VML) in five patients has recently been reported with a generally favorable outcome. Further studies are necessary for a better understanding of the mechanism(s) behind acellular bioscaffold-mediated skeletal muscle repair, and for combination cell-based/bioscaffold based approaches. The present overview highlights the current thinking on bioscaffold-based remodeling including the associated mechanisms and the future of scaffold-based skeletal muscle reconstruction.
authors.affiliation: 1 McGowan Institute for Regenerative Medicine, 2 Department of Surgery, 3 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Sicari
authors.affiliation: 1 McGowan Institute for Regenerative Medicine, 2 Department of Surgery, 3 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Jenna L
authors.initials: JL
authors.lastname: Dziki
authors.affiliation: 1 McGowan Institute for Regenerative Medicine, 2 Department of Surgery, 3 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Badylak
keywords: Tissue engineering; bioscaffolds; extracellular matrix (ECM); regenerative medicine; skeletal muscle reconstruction; volumetric muscle loss (VML)