title: Primary Diffuse Large B-Cell Lymphoma of the Mandible: Case Report and Review of the Literature.
abstract: In the oral cavity, extranodal non-Hodgkin's lymphoma can occur in the periapical region either in the maxilla or mandible. Also, it can mimic inflammatory lesions that arise around the teeth apices such as periapical granuloma, radicular cyst and osteomyelitis. Misdiagnosis of lymphomas in the jaws may reduce the chance of successful treatment and worsen the prognosis. Therefore, any growth of periapical tissue must be submitted for histopathological evaluation to avoid a delay in the diagnosis. We present a case of extranodal non-Hodgkin's lymphoma of a 53-year-old male in the right posterior mandible that was initially misdiagnosed as a reactive periapical lesion. This case illustrates the importance for both the pathologist and the clinician of considering malignant lesions such as lymphoma in the differential diagnosis of periapical radiolucency.
authors.affiliation: Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, Md., USA.
authors.forename: Amr
authors.initials: A
authors.lastname: Bugshan
authors.affiliation: Towson Periodontal Associates, Towson, Md., USA.
authors.forename: James
authors.initials: J
authors.lastname: Kassolis
authors.affiliation: Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, Md., USA.
authors.forename: John
authors.initials: J
authors.lastname: Basile
keywords: Mandible; Non-Hodgkin's lymphoma; Oral cancer; Oral cavity; Periapical lesion; Swelling