title: New triterpenoids from the latex of Euphorbia resinifera Berg.
abstract: Nine novel compounds, six euphane triterpenes, Euphorol A-D (1-4), H (8) and I (9), and three tirucallane triterpenes, Euphorol E-G (5-7) including four nortriterpenes, together with seven known compounds (10-16) have been isolated from the methanol extraction of Euphorbium. Their structures were established on the basis of extensive analyses of their HR-ESI-MS, UV, IR, 1D and 2D NMR methods. A putative biogenetic relationship to these compounds was proposed. The cytotoxicity of all these isolates against MCF-7, U937 and C6 cancer cell lines was evaluated. Compounds 1-3, 10, 11 and 13-16 exhibited moderate cytotoxic activities.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Wang
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Honggang
authors.initials: H
authors.lastname: Liang
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Guihua
authors.initials: G
authors.lastname: Wang
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yao
authors.affiliation: College of Pharmacy, Xinjiang Medical University, Urumqi 830054, PR China.
authors.forename: Rena
authors.initials: R
authors.lastname: Kasimu
authors.affiliation: Department of Pharmacology, Mudanjiang Medical College, Mudanjiang 157011, PR China.
authors.forename: Zhaohua
authors.initials: Z
authors.lastname: Wu
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: 13504051049@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China; College of Pharmacy, Xinjiang Medical University, Urumqi 830054, PR China. Electronic address: wangjh_716@163.com.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D007840:Latex / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007840:Latex; D010936:Plant Extracts; D014315:Triterpenes; C514393:tirucallane
keywords: Cytotoxicity; Euphane triterpenes; Euphorbia; Euphorbium; Tirucallane triterpenes