title: Prolonged Survival in a Patient with a Pancreatic Acinar Cell Carcinoma.
abstract: Pancreatic acinar cell carcinoma (ACC) is a rare entity. Herein we present the case of a 50-year-old male patient with an unlimited mass on the pancreatic corpus and tail with peripancreatic effusion and multiple metastases in the liver and spleen. A liver biopsy showed a pancreatic ACC. The patient received 9 cycles of gemcitabine plus oxaliplatin (GEMOX regimen), which had to be stopped because of a persistent grade 2 neuropathy. A CT scan showed complete response after 14 years. At the age of 61 years, a localized prostatic cancer was diagnosed, treated by prostatectomy. The patient carried a BRCA2 mutation. None of the precedent case reports describe a chemosensibility to the GEMOX regimen. In spite of the lack of study in these patients, chemotherapy with oxaliplatin seems to be the most effective. Long survival can be expected.
authors.affiliation: Department of Medical Oncology, University Hospital, Lille, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Ploquin
authors.affiliation: Department of Medical Oncology, University Hospital, Lille, France.
authors.forename: Capucine
authors.initials: C
authors.lastname: Baldini
authors.affiliation: Department of Medical Oncology, University Hospital, Lille, France.
authors.forename: Perrine
authors.initials: P
authors.lastname: Vuagnat
authors.affiliation: Department of Medical Oncology, University Hospital, Lille, France.
authors.forename: Samira
authors.initials: S
authors.lastname: Makhloufi
authors.affiliation: Department of Medical Oncology, University Hospital, Lille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Desauw
authors.affiliation: Department of Medical Oncology, University Hospital, Lille, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hebbar
keywords: BRCA2 mutation; Long-term survival; Pancreatic acinar cell carcinoma