title: Reduced Antioxidant and Cytoprotective Capacity in Allergy and Asthma.
abstract: In asthma, reactive oxygen species induce damage to biomolecules like proteins. This oxidative stress can promote inflammation, but its contribution to asthma pathology is controversial, not in the least because antioxidant interventions have proven rather unsuccessful. Recent studies indicate that the oxidative stress at baseline can be predictive of the fall in FEV1 upon an allergen challenge and of sensitization to an allergen. Interestingly, this baseline oxidative stress correlated with the capacity of antioxidant and cytoprotective responses to deal with reactive oxygen species, but not with inflammatory parameters. These findings have led to several considerations in relation to antioxidant trials that are discussed. Trials should be complemented by in-depth analyses of the failing antioxidant and cytoprotective responses and their consequences for cellular function in asthma.
authors.affiliation: 1 Department of Respiratory Medicine, and.|2 Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: René
authors.initials: R
authors.lastname: Lutter
authors.affiliation: 2 Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: Bas
authors.initials: B
authors.lastname: van Lieshout
authors.affiliation: 1 Department of Respiratory Medicine, and.|2 Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: Caterina
authors.initials: C
authors.lastname: Folisi
mesh_terms: D000485:Allergens / Q000187:drug effects; D000975:Antioxidants / Q000627:therapeutic use*; D001249:Asthma / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000276:immunology*
chemical_list: D000485:Allergens; D000975:Antioxidants; D017382:Reactive Oxygen Species
keywords: Nrf-2; allergen; exacerbation; oxidative stress