title: SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer.
abstract: Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during cell cycle progression. Many important cell cycle regulators, including many oncogenes and tumor suppressors, are functionally regulated via SUMOylation. The dynamic SUMOylation pattern observed throughout the cell cycle is ensured via distinct spatial and temporal regulation of the SUMO machinery. Additionally, SUMOylation cooperates with other post-translational modifications to mediate cell cycle progression. Deregulation of these SUMOylation and deSUMOylation enzymes causes severe defects in cell proliferation and genome stability. Different types of cancer were recently shown to be dependent on a functioning SUMOylation system, a finding that could be exploited in anticancer therapies.
authors.affiliation: Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. Electronic address: k.eifler@lumc.nl.
authors.forename: Karolin
authors.initials: K
authors.lastname: Eifler
authors.affiliation: Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. Electronic address: vertegaal@lumc.nl.
authors.forename: Alfred C O
authors.initials: ACO
authors.lastname: Vertegaal
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D058207:Sumoylation
keywords: SUMO; SUMOylation; cancer; cell cycle; mitosis