title: Can upper airway surgery for OSA protect against cardiovascular sequelae via effects on coagulation?
abstract: CONCLUSIONS
  Upper airway surgery is associated with salutary effects on the blood coagulation characteristics of OSA patients, a benefit that may be protective against cardiac and cerebrovascular morbidity and mortality.
  
  
  OBJECTIVE
  Increased blood coagulation is an important factor linking OSA and cardiovascular complications. Surgery is an important method to treat OSA, but the effect of surgery on blood coagulation in OSA patients is unknown.
  
  
  METHODS
  the authors performed a prospective clinical trial of adult OSA patients who underwent surgery from 2012-2014. Pre-operative and post-operative blood coagulation parameters and polysomnography (PSG) results were compared.
  
  
  RESULTS
  There were 61 subjects. The total rate of success in curing OSA was 11.5%. The rate of response after surgery was 40.8%. Overall, the Apnea-Hypopnea Index (AHI) improved after surgery (from 39.8 3 ± 24.49 to 25.9 7 ± 18.53, p < 0.01). After surgery, serum platelet counts (PLT) decreased (from 242.5 ± 52.6 to 230.9 ± 40.7, p=0.01), and Fibrinogen (FIB) levels declined (from 262.5 ± 52.5 to 247.3 ± 44.4, p = 0.02). Other blood coagulation parameters also improved: prothrombin time (PT) (from 10.6 2 ± 0.62 to 10.8 6 ± 0.70, p=0.01), activated partial thromboplastin time (APTT) (from 26.9 8 ± 4.94 to 27.7 8 ± 3.02, p = 0.06), and Thrombin time (TT) (from 19.5 3 ± 0.84 to 20.1 1 ± 1.31, p < 0.01).
authors.affiliation: a Department of Otolaryngology Head & Neck Surgery , Beijing Anzhen Hospital, Capital Medical University , Beijing , PR China ;
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhan
authors.affiliation: b Department of Otolaryngology Head & Neck Surgery , Beijing Chaoyang Hospital, Capital Medical University , Beijing , PR China ;
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: b Department of Otolaryngology Head & Neck Surgery , Beijing Chaoyang Hospital, Capital Medical University , Beijing , PR China ;
authors.forename: Ningyu
authors.initials: N
authors.lastname: Wang
authors.affiliation: a Department of Otolaryngology Head & Neck Surgery , Beijing Anzhen Hospital, Capital Medical University , Beijing , PR China ;
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Ge
authors.affiliation: c Section of Otolaryngology-Head and Neck Surgery, Department of Surgery , the University of Chicago , Chicago , IL , USA ;
authors.forename: Jayant M
authors.initials: JM
authors.lastname: Pinto
authors.affiliation: d Department of Cardiology , Beijing Anzhen Hospital, Capital Medical University , Beijing , PR China.
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Wu
authors.affiliation: a Department of Otolaryngology Head & Neck Surgery , Beijing Anzhen Hospital, Capital Medical University , Beijing , PR China ;
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wei
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D055815:Young Adult
keywords: Obstructive sleep apnea (OSA); blood coagulation; cardiovascular disease; polysomnography; upper airway surgery