title: P2X and P2Y receptor signaling in red blood cells.
abstract: Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively. P2 receptors comprise P2X and P2Y receptors, and have well-established roles in leukocyte and platelet biology. Emerging evidence indicates important roles for these receptors in red blood cells. P2 receptor activation stimulates a number of signaling pathways in progenitor red blood cells resulting in microparticle release, reactive oxygen species formation, and apoptosis. Likewise, activation of P2 receptors in mature red blood cells stimulates signaling pathways mediating volume regulation, eicosanoid release, phosphatidylserine exposure, hemolysis, impaired ATP release, and susceptibility or resistance to infection. This review summarizes the distribution of P2 receptors in red blood cells, and outlines the functions of P2 receptor signaling in these cells and its implications in red blood cell biology.
authors.affiliation: School of Biological Sciences, University of Wollongong Wollongong, NSW, Australia ; Centre for Medical and Molecular Bioscience, University of Wollongong Wollongong, NSW, Australia ; Illawarra Health and Medical Research Institute Wollongong, NSW, Australia.
authors.forename: Ronald
authors.initials: R
authors.lastname: Sluyter
keywords: P2X1 receptor; P2X7 receptor; P2Y1 receptor; P2Y13 receptor; adenosine triphosphate; erythrocyte; purinergic receptor; red blood cell