title: Use of proton pump inhibitors in hematopoietic stem cell transplantation does not increase the frequency of febrile neutropenia.
abstract: OBJECTIVE
  Despite the fact that proton pump inhibitor (PPI) use is a risk factor for infections in heterogeneous groups of patients, there are only a limited data related to PPI use and febrile neutropenic episodes (FNEs) in hematopoietic stem cell transplantation (HSCT) patients.
  
  
  METHODS
  In a 7-year period, we retrospectively reviewed 145 HSCT data to identify a risk factor for PPI use for febrile neutropenia. The follow-up process of 125 (86.2%) of the HSCTs was complicated with FNEs.
  
  
  RESULTS
  A multivariate analysis indicated that PPI use was not significantly associated with FNEs (Odds ratio [OR]: 0.46; 95% Confidence Interval [CI] 0.12-2.16; p = 0.24) or bacterial culture positivity (OR: 1.37; 95% CI 0.45-4.18; p = 0.58).
  
  
  CONCLUSIONS
  Our study revealed that PPI use does not appear to be a risk factor for FNE or bacterial culture positivity for HSCT patients but further studies are needed.
authors.affiliation: Department of Hematology, Internal Medicine, and Microbiology; Ege University Medical School, Izmir, Turkey. zjdocchina@163.com.
authors.forename: M C
authors.initials: MC
authors.lastname: Ozkan
authors.forename: A
authors.initials: A
authors.lastname: Donmez
authors.forename: A
authors.initials: A
authors.lastname: Arslan
authors.forename: S
authors.initials: S
authors.lastname: Aydemir
authors.forename: M
authors.initials: M
authors.lastname: Tombuloglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D064147:Febrile Neutropenia / Q000139:chemically induced / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors