title: The UCSC Genome Browser database: 2016 update.
abstract: For the past 15 years, the UCSC Genome Browser (http://genome.ucsc.edu/) has served the international research community by offering an integrated platform for viewing and analyzing information from a large database of genome assemblies and their associated annotations. The UCSC Genome Browser has been under continuous development since its inception with new data sets and software features added frequently. Some release highlights of this year include new and updated genome browsers for various assemblies, including bonobo and zebrafish; new gene annotation sets; improvements to track and assembly hub support; and a new interactive tool, the "Data Integrator", for intersecting data from multiple tracks. We have greatly expanded the data sets available on the most recent human assembly, hg38/GRCh38, to include updated gene prediction sets from GENCODE, more phenotype- and disease-associated variants from ClinVar and ClinGen, more genomic regulatory data, and a new multiple genome alignment.
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA mspeir@soe.ucsc.edu.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Speir
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Ann S
authors.initials: AS
authors.lastname: Zweig
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Kate R
authors.initials: KR
authors.lastname: Rosenbloom
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Raney
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Benedict
authors.initials: B
authors.lastname: Paten
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Parisa
authors.initials: P
authors.lastname: Nejad
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Brian T
authors.identifier: http://orcid.org/0000-0001-6382-9738
authors.initials: BT
authors.lastname: Lee
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Katrina
authors.initials: K
authors.lastname: Learned
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Donna
authors.initials: D
authors.lastname: Karolchik
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Angie S
authors.initials: AS
authors.lastname: Hinrichs
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Steve
authors.initials: S
authors.lastname: Heitner
authors.affiliation: Invitae, San Francisco, CA 94017, USA.
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Harte
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Haeussler
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Luvina
authors.initials: L
authors.lastname: Guruvadoo
authors.affiliation: Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Pauline A
authors.initials: PA
authors.lastname: Fujita
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Eisenhart
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Diekhans
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Hiram
authors.initials: H
authors.lastname: Clawson
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Casper
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Galt P
authors.initials: GP
authors.lastname: Barber
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA Howard Hughes Medical Institute, University of California Santa Cruz, CA 95064, USA.
authors.forename: David
authors.initials: D
authors.lastname: Haussler
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Kuhn
authors.affiliation: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: W James
authors.initials: WJ
authors.lastname: Kent
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D004194:Disease / Q000235:genetics; D005796:Genes; D016678:Genome; D023281:Genomics; D006801:Humans; D051379:Mice; D058977:Molecular Sequence Annotation; D012984:Software