title: Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies.
abstract: A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.
authors.affiliation: University of Belgrade, Faculty of Pharmacy, Department of Organic Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia.
authors.forename: Milena
authors.initials: M
authors.lastname: Simic
authors.affiliation: University of Belgrade, Faculty of Pharmacy, Department of Organic Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia.
authors.forename: Nikola
authors.initials: N
authors.lastname: Paunovic
authors.affiliation: University of Belgrade, Faculty of Pharmacy, Department of Organic Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Boric
authors.affiliation: University of Belgrade, Faculty of Pharmacy, Department of Organic Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Randjelovic
authors.affiliation: University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Laboratory for Microbial Molecular Genetics and Ecology, Vojvode Stepe 444a, P.P. Box 23, 11010 Belgrade, Serbia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Vojnovic
authors.affiliation: University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Laboratory for Microbial Molecular Genetics and Ecology, Vojvode Stepe 444a, P.P. Box 23, 11010 Belgrade, Serbia.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Nikodinovic-Runic
authors.affiliation: University of Belgrade, Faculty of Medicine, National Reference Medical Mycology Laboratory, Institute of Microbiology and Immunology, Dr Subotica 1, 11000 Belgrade, Serbia.
authors.forename: Marina
authors.initials: M
authors.lastname: Pekmezovic
authors.affiliation: University of Belgrade, Faculty of Pharmacy, Department of Organic Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: vladimir.savic@pharmacy.bg.ac.rs.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Savic
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000166:cytology / Q000187:drug effects*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D049934:Isocoumarins
keywords: Antifungal compounds; Candida species; Isocoumarin derivatives