title: An Increase of Plasma Advanced Oxidation Protein Products Levels Is Associated with Cardiovascular Risk in Incident Peritoneal Dialysis Patients: A Pilot Study.
abstract: Advanced oxidation protein products (AOPPs) are considered as markers and even mediators of the proinflammatory effect of oxidative stress in uremia. We hypothesized that an increase of oxidative stress associated with peritoneal dialysis (PD), estimated by the variation of plasma AOPPs over time, might be associated with cardiovascular (CV) risk and overall prognosis. In 48 PD patients, blood samples were collected on two occasions: the first one in the first six months after starting PD therapy and the second one, one year after. The plasma AOPPs level variation over the first year on PD was significantly associated with CV antecedents and also with CV prognosis. In those patients in whom the AOPPs levels increased more than 50% above the baseline value, a significant association with past and future CV disease was confirmed. These patients had 4.7 times greater risk of suffering later CV disease than those with a smaller increase, even after adjusting for previous CV history. Our data suggest that the increase of AOPPs plasma level over the first year on PD is conditioned by CV antecedents but also independently predicts CV prognosis. AOPPs plasma levels seem to represent the CV status of PD patients with sufficient sensitivity to identify those with a clearly sustained higher CV risk.
authors.affiliation: Department of Nephrology, Hospital Universitario La Paz, IdiPAZ, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Gonzalez
authors.affiliation: Department of Nephrology, Hospital Universitario La Paz, IdiPAZ, Spain.
authors.forename: Maria-Auxiliadora
authors.initials: MA
authors.lastname: Bajo
authors.affiliation: Renal Medicine and Baxter Novum, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Carrero
authors.affiliation: Renal Medicine and Baxter Novum, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindholm
authors.affiliation: Department of Biochemistry, Hospital Universitario La Paz, IdiPAZ, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Grande
authors.affiliation: Department of Nephrology, Hospital Universitario La Paz, IdiPAZ, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Sánchez-Villanueva
authors.affiliation: Department of Nephrology, Hospital Universitario La Paz, IdiPAZ, Spain.
authors.forename: Gloria
authors.initials: G
authors.lastname: Del Peso
authors.affiliation: Section of Biostatistics, Hospital Universitario La Paz, IdiPAZ, Spain.
authors.forename: Mariana
authors.initials: M
authors.lastname: Díaz-Almirón
authors.affiliation: Department of Endocrinology, Hospital Universitario Ramón y Cajal, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Iglesias
authors.affiliation: Department of Endocrinology, Hospital Universitario Ramón y Cajal, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Díez
authors.affiliation: Department of Nephrology, Hospital Universitario La Paz, IdiPAZ, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Selgas
mesh_terms: D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000032:analysis*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010530:Peritoneal Dialysis; D010865:Pilot Projects; D015995:Prevalence; D012307:Risk Factors
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers