title: Clinical manifestations and outcomes of severe malaria among children admitted at Rungwe and Kyela district hospitals in south-western Tanzania.
abstract: Malaria remains as an important public health and a major cause of childhood death and paediatric hospital admission in sub-Saharan Africa. This prospective hospital based cross sectional study was conducted from April 2007 to April 2008. The main objective was to assess clinical manifestations and outcomes of severe malaria in children admitted to district hospital in Rungwe and Kyela in south-western Tanzania. A total of 1371 children were selected as screening group of which 409 (29.8%) were tested positive for malaria. Mean age of the children was 2.7 (95%CI= 2.5, 2.8) years and the majority (86%) were under five years of age. The proportion of children severe malaria in Rungwe was significantly higher than that of Kyela by 21.3% (P=0.002). The common symptoms of severe malaria during admission were convulsions (50.9%) compensated shock (30.6%), prostration (29.1%) and symptomatic severe anaemia (14.9%). The case fatality rate (CFR) was 4.6% and the cure rate (CR) was 95.4%. Children with suspected severe acidosis and symptomatic severe anemia were 4.8 (95%CI=1.6, 14.6) and 5.5 (95%CI 1.1, 28.2), respectively, more likely to die compared to those without these symptoms. The proportion of deaths among children presenting ≥5 symptoms was 32.1% higher than among those presenting one symptom (OR =0.50, 95%CI 0.125-2.000; P=0.000). Convulsions and compensated shock were the leading symptoms at admission. Suspected severe acidosis and symptomatic severe anemia were the predictors of mortality for children. In order to reduce mortality among admitted children with severe malaria there is a need for health providers to deploy strategic management of fatal prognostic factors. In conclusion, convulsion and compensated shock were the leading symptoms among children at admission and that suspected severe acidosis and symptomatic severe anemia were the predictors of mortality. It is therefore important to emphasis early diagnosis and prompt treatment of severe cases of malaria to minimize mortality among children.
authors.affiliation: Tukuyu Medical Research Centre, P O. Box 538, Tukuyu, Tanzania. kalingaaka@yahoo.com
authors.forename: Akili
authors.initials: A
authors.lastname: Kalinga
authors.forename: Mary
authors.initials: M
authors.lastname: Mayige
authors.forename: Gibson
authors.initials: G
authors.lastname: Kagaruki
authors.forename: Amani
authors.initials: A
authors.lastname: Shao
authors.forename: Brighton
authors.initials: B
authors.lastname: Mwakyusa
authors.forename: Frank
authors.initials: F
authors.lastname: Jacob
authors.forename: Charles
authors.initials: C
authors.lastname: Mwesiga
mesh_terms: D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006767:Hospitals, District; D006801:Humans; D007223:Infant; D008288:Malaria / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D011446:Prospective Studies; D015996:Survival Rate; D013636:Tanzania / Q000453:epidemiology; D016896:Treatment Outcome