title: Correlation of serum chromium, zinc, magnesium and SOD levels with HbA1c in type 2 diabetes: A cross sectional analysis.
abstract: The loss of dynamic integrity between homoeostasis of free radicals and antioxidants causes the development of complications like retinopathy, nephropathy, neuropathy, atherosclerosis and cardiovascular diseases in T2DM.
  
  
  OBJECTIVE
  To assess the concentrations of serum chromium, zinc, magnesium and SOD in subjects of T2DM and control and to investigate the effect of these variables versus HbA1c.
  
  
  RESULTS
  Insigniﬁcant difference (P=0.493) was reported in age (50±4.7 year compared with 50±7.2 year), while body mass Index (23±2kg/m(2) compared with 26±4.5kg/m(2)) between the T2DM subjects and control subject showed significant difference (<0.0001). Inverse Pearson correlation coefficient, r (-0.376), (-0.689), (-0.05), (-0.05), (-0.40), (-0.14), (-0.342) and (-0.548) were established when HbA1c of control and T2DM patients were compared with control and T2DM patients of serum Cr, Zn, Mg and SOD variables in that order. The overall "p"-value demonstrated highly signiﬁcant result at p<0.0001 between the T2DM subjects and controls.
  
  
  CONCLUSIONS
  Strong association between serum chromium and SOD in relation to HbA1c in this study gives a strong point that these variables could be used as markers of cell injury with the intention in further part of life en route to progressive complications in T2DM.
authors.affiliation: Rajiv Gandhi Centre for Diabetes & Endocrinology, J.N Medical College, Aligarh Muslim University, Aligarh-202002, India.
authors.forename: Zephy
authors.initials: Z
authors.lastname: Doddigarla
authors.affiliation: Fish Molecular Biology & Endocrinology Lab, Department of Zoology, A.M.U., Aligarh, India.
authors.forename: Iqbal
authors.initials: I
authors.lastname: Parwez
authors.affiliation: Rajiv Gandhi Centre for Diabetes & Endocrinology, J.N Medical College, Aligarh Muslim University, Aligarh-202002, India. Electronic address: jamalahmad11@rediffmail.com.
authors.forename: Jamal
authors.initials: J
authors.lastname: Ahmad
mesh_terms: D016022:Case-Control Studies; D002857:Chromium / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*; D015032:Zinc / Q000097:blood*
chemical_list: D002857:Chromium; D006442:Glycated Hemoglobin; D008274:Magnesium; D013482:Superoxide Dismutase; D015032:Zinc
keywords: HbA1c; SOD; T2DM