title: Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches.
abstract: Cerebral malaria is a severe neuropathological complication of Plasmodium falciparum infection. It results in high mortality and post-recovery neuro-cognitive disorders in children, even after appropriate treatment with effective anti-parasitic drugs. While the complete landscape of the pathogenesis of cerebral malaria still remains to be elucidated, numerous innovative approaches have been developed in recent years in order to improve the early detection of this neurological syndrome and, subsequently, the clinical care of affected patients. In this review, we briefly summarize the current understanding of cerebral malaria pathogenesis, compile the array of new biomarkers and tools available for diagnosis and research, and describe the emerging therapeutic approaches to tackle this pathology effectively.
authors.affiliation: Center for the Study of Complex Malaria in India, Ispat General Hospital Rourkela, India.
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Sahu
authors.affiliation: Department of Pathology, Ispat General Hospital Rourkela, India.
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Satpathi
authors.affiliation: Department of Pathology, Ispat General Hospital Rourkela, India.
authors.forename: Prativa K
authors.initials: PK
authors.lastname: Behera
authors.affiliation: Center for the Study of Complex Malaria in India, Ispat General Hospital Rourkela, India.
authors.forename: Saroj K
authors.initials: SK
authors.lastname: Mishra
authors.affiliation: Center for the Study of Complex Malaria in India, Ispat General Hospital Rourkela, India.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Mohanty
authors.affiliation: Department of Microbiology, New York University School of Medicine New York, NY, USA ; Department of Pathology, The University of Sydney Sydney, NSW, Australia.
authors.forename: Samuel Crocodile
authors.initials: SC
authors.lastname: Wassmer
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D003955:Diagnostic Tests, Routine / Q000379:methods*; D004358:Drug Therapy / Q000379:methods*; D006801:Humans; D016779:Malaria, Cerebral / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*
chemical_list: D015415:Biomarkers
keywords: Plasmodium falciparum; cerebral malaria; diagnostic; new therapies; pathophysiology; research tools