title: Ten-year trends in urinary concentrations of triclosan and benzophenone-3 in the general U.S. population from 2003 to 2012.
abstract: Despite their popular use and emerging evidences of adverse health effects, consequent trends in population level triclosan and benzophenone-3 exposure have been poorly evaluated. Therefore, we examined temporal trends of urinary triclosan and benzophenone-3 concentration in the general U.S. population by combining five cycles of National Health and Nutritional Examination Survey (NHANES, 2003-2012) data. We calculated percent changes and the least square geometric means (LSGMs) of urinary triclosan and benzophenone-3 concentration from 10,232 participants by using multivariable regression models. As a result, LSGM concentration of urinary triclosan and benzophenone-3 did not show statistically significant changes over the study period. [Percent change (95% CI): Triclosan, -7.35% (-20.86, 8.47); Benzophenone-3, 7.08% (-27.88, 58.99)] However, we found decreasing trend of urinary triclosan concentration and increasing trend of urinary benzophenone-3 concentration since 2005-2006. Socio-demographic factors which affected urinary concentration of triclosan and benzophenone-3 persisted throughout 10 year study period. Highest income group showed higher level of urinary triclosan and benzophenone-3 concentration. Overall concentration of benzophenone-3 was higher in female than in male, and higher in non-Hispanic Whites than any other races/ethnicities.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Changwoo
authors.initials: C
authors.lastname: Han
authors.affiliation: Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea; Environmental Health Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Youn-Hee
authors.initials: YH
authors.lastname: Lim
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea; Environmental Health Center, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: ychong1@snu.ac.kr.
authors.forename: Yun-Chul
authors.initials: YC
authors.lastname: Hong
mesh_terms: D000891:Anti-Infective Agents, Local / Q000652:urine*; D001577:Benzophenones / Q000652:urine*; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D016018:Least-Squares Analysis; D008297:Male; D015999:Multivariate Analysis; D009749:Nutrition Surveys; D012959:Socioeconomic Factors; D014260:Triclosan / Q000652:urine*; D014481:United States
chemical_list: D000891:Anti-Infective Agents, Local; D001577:Benzophenones; D014260:Triclosan; C005290:oxybenzone
keywords: Benzophenone-3; NHANES; Trends; Triclosan