title: Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease.
abstract: Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson's disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein transgenic Drosophila PD models. In addition, the neuroprotective effect of TGY was also evaluated in the human dopaminergic neuroblastoma SH-SY5Y cell line treated with rotenone and the rotenone intoxicated hemi-parkinsonian rats. In rotenone-induced PD models, TGY improved survival rate, alleviated impaired locomotor function of Drosophila, mitigated the loss of dopaminergic neurons in hemi-parkinsonian rats and alleviated apoptotic cell death in SH-SY5Y cells; in α-synuclein transgenic Drosophila, TGY reduced the level of α-synuclein and prevented degeneration of dopaminergic neurons. Conclusively, TGY is neuroprotective in PD models both in vivo and in vitro.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.|Mr. &Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, Hong Kong Baptist University, Hong Kong.
authors.forename: Liang-Feng
authors.initials: LF
authors.lastname: Liu
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.|Mr. &Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, Hong Kong Baptist University, Hong Kong.
authors.forename: Ju-Xian
authors.initials: JX
authors.lastname: Song
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao.
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Lu
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.|Mr. &Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, Hong Kong Baptist University, Hong Kong.
authors.forename: Ying-Yu
authors.initials: YY
authors.lastname: Huang
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.|Mr. &Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, Hong Kong Baptist University, Hong Kong.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.|Mr. &Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, Hong Kong Baptist University, Hong Kong.
authors.forename: Lei-Lei
authors.initials: LL
authors.lastname: Chen
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.|Mr. &Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, Hong Kong Baptist University, Hong Kong.
authors.forename: Siva Sundara Kumar
authors.initials: SS
authors.lastname: Durairajan
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.|Mr. &Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, Hong Kong Baptist University, Hong Kong.
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.|Mr. &Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, Hong Kong Baptist University, Hong Kong.
authors.forename: Min
authors.initials: M
authors.lastname: Li
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D017209:Apoptosis / Q000187:drug effects; D002452:Cell Count; D045744:Cell Line, Tumor; D002853:Chromatography, Liquid; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D059290:Dopaminergic Neurons / Q000187:drug effects* / Q000378:metabolism*; D004330:Drosophila; D004336:Drug Antagonism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008516:Medicine, Chinese Traditional; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D012402:Rotenone / Q000494:pharmacology; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D051844:alpha-Synuclein; C574204:tianma gouteng yin; D012402:Rotenone; D004298:Dopamine