title: The Promise of Gene Therapy for Pancreatic Cancer.
abstract: Unlike for other digestive cancer entities, chemotherapy, radiotherapy, and targeted therapies have, so far, largely failed to improve patient survival in pancreatic adenocarcinoma (PDAC), which remains the fourth leading cause of cancer-related death in Europe and the United States. In this context, gene therapy may offer a new avenue for patients with PDAC. In this review, we explore the research currently ongoing in French laboratories aimed at defeating PDAC using nonviral therapeutic gene delivery, targeted transgene expression, or oncolytic virotherapy that recently or will soon bridge the gap between experimental models of cancer and clinical trials. These studies are likely to change clinical practice or thinking about PDAC management, as they represent a major advance not only for PDAC but may also significantly influence the field of gene-based molecular treatment of cancer.
authors.affiliation: 1 Université de Nice Sophia Antipolis , Nice, France .|2 Laboratoire TIRO , UMRE 4320, CEA, Nice, France .
authors.forename: Georges
authors.initials: G
authors.lastname: Vassaux
authors.affiliation: 3 German Cancer Research Center (DKFZ) , Tumor Virology/F010, Heidelberg, Germany .
authors.forename: Assia
authors.initials: A
authors.lastname: Angelova
authors.affiliation: 4 Centre de Biophysique Moléculaire, CNRS UPR4301 and University of Orléans , Orléans, France .
authors.forename: Patrick
authors.initials: P
authors.lastname: Baril
authors.affiliation: 4 Centre de Biophysique Moléculaire, CNRS UPR4301 and University of Orléans , Orléans, France .
authors.forename: Patrick
authors.initials: P
authors.lastname: Midoux
authors.affiliation: 3 German Cancer Research Center (DKFZ) , Tumor Virology/F010, Heidelberg, Germany .
authors.forename: Jean
authors.initials: J
authors.lastname: Rommelaere
authors.affiliation: 5 INSERM , UMR1037 CRCT, F-31000 Toulouse, France .|6 Université Toulouse III-Paul Sabatier , F-31000 Toulouse, France .
authors.forename: Pierre
authors.initials: P
authors.lastname: Cordelier
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D000260:Adenoviruses, Human / Q000235:genetics / Q000378:metabolism; D002986:Clinical Trials as Topic; D003842:Deoxycytidine Kinase / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009703:Nucleoside-Phosphate Kinase / Q000235:genetics / Q000378:metabolism; D050130:Oncolytic Virotherapy / Q000379:methods*; D030102:Orthoreovirus, Mammalian / Q000235:genetics / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D017481:Receptors, Somatostatin / Q000235:genetics / Q000378:metabolism; D019076:Transgenes
chemical_list: D035683:MicroRNAs; D017481:Receptors, Somatostatin; C574734:SSTR2 protein, human; D003842:Deoxycytidine Kinase; C023276:uridine monophosphate kinase; D009703:Nucleoside-Phosphate Kinase