title: Translational Insights Into Peroxisome Proliferator-Activated Receptors in Experimental Acute Pancreatitis.
abstract: Acute pancreatitis (AP) is an inflammatory disorder of the exocrine pancreas frequently associated with metabolic causes, contributing factors, or consequences, including hypertriglyceridemia, obesity, and disorders of intermediary metabolism, respectively. To date, there is no specific therapy for this disease. Future optimal therapy should correct both inflammatory and metabolic components of the disease. Peroxisome proliferator-activated receptors (PPARs) are lipid-sensing nuclear receptors that control inflammatory and metabolic pathways via ligand-dependent and ligand-independent mechanisms. There are 3 known subtypes, PPAR-α, PPAR-β/δ, and PPAR-γ, which are differentially expressed in various tissues. The PPARs interact closely with other transcription factors such as nuclear factor κB and signal tranducers and activators of transcription that have pivotal roles in the pathobiology of AP. In this comprehensive review, we summarize the role of PPARs in AP, highlighting important in vitro and in vivo experimental findings. Finally, we propose future research directions as well as potential translational use of PPAR agonists in the treatment of AP.
authors.affiliation: From the *Department of Integrated Traditional and Western Medicine, Sichuan Provincial Pancreatitis Center, West China Hospital, Sichuan University, Chengdu, China; †NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital; and ‡Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Peter
authors.initials: P
authors.lastname: Szatmary
authors.forename: Meihua
authors.initials: M
authors.lastname: Wan
authors.forename: Shameena
authors.initials: S
authors.lastname: Bharucha
authors.forename: Muhammad
authors.initials: M
authors.lastname: Awais
authors.forename: Wenfu
authors.initials: W
authors.lastname: Tang
authors.forename: David N
authors.initials: DN
authors.lastname: Criddle
authors.forename: Qing
authors.initials: Q
authors.lastname: Xia
authors.forename: Robert
authors.initials: R
authors.lastname: Sutton
mesh_terms: D000208:Acute Disease; D000818:Animals; D004358:Drug Therapy / Q000379:methods / Q000639:trends; D005544:Forecasting; D006801:Humans; D008024:Ligands; D010195:Pancreatitis / Q000188:drug therapy / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D057170:Translational Research, Biomedical / Q000379:methods* / Q000639:trends
chemical_list: D008024:Ligands; D047492:Peroxisome Proliferator-Activated Receptors; D014157:Transcription Factors