title: [Levels of IL-8,IL-10 in patients with chronic periodontitis and coronary heart disease].
abstract: OBJECTIVE
  To detect the level of interleukin-8 (IL-8) and interleukin-10 (IL-10) in serum and gingival crevicular fluid in patients with chronic severe periodontitis (CP) and coronary heart disease (CHD) and investigate the relationship between CP and CHD.
  
  
  METHODS
  Thirty patients with CHD and CP(group A), twenty-five patients with only CP(group B) and thirty healthy controls (group C) were included in this study. Gingival crevicular fluid and serum IL-8, IL-10 levels were detected by ELISA. SPSS 11.5 software package was used for statistical analysis.
  
  
  RESULTS
  The periodontal indexes including bleeding on probing and probing depth were significantly different among the 3 groups. In group A and B, the level of IL-8 in gingival crevicular fluid and serum were significantly lower, whereas the IL-10 level was significantly higher, in comparison to those in group C (P<0.05).
  
  
  CONCLUSIONS
  IL-8 and IL-10 may be associated with the pathogenesis of periodontitis and CHD. There may be a relationship between CHD and CP.
authors.affiliation: Department of Stomatology, Panjin Central Hospital. Panjin 124000; China.E-mail:pjmb@sina.com.
authors.forename: Xiu-juan
authors.initials: XJ
authors.lastname: Bing
authors.forename: Xiao-ju
authors.initials: XJ
authors.lastname: Sun
authors.forename: Guo-han
authors.initials: GH
authors.lastname: Shen
authors.forename: Hong
authors.initials: H
authors.lastname: Xie
authors.forename: Ming-yang
authors.initials: MY
authors.lastname: Ma
mesh_terms: D002681:China / Q000453:epidemiology; D055113:Chronic Periodontitis / Q000453:epidemiology / Q000378:metabolism*; D003327:Coronary Disease / Q000453:epidemiology / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005883:Gingival Crevicular Fluid / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D016209:Interleukin-8 / Q000378:metabolism*; D010512:Periodontal Index
chemical_list: D016209:Interleukin-8; D016753:Interleukin-10