title: Feasibility and safety of conservative surgery for the treatment of spermatic cord leiomyosarcoma.
abstract: OBJECTIVE
  To assess the feasibility and the safety of conservative surgery to treat spermatic cord leiomyosarcoma.
  
  
  METHODS
  Patients undergoing inguinoscrotal exploration in 10 different Urological Centers with diagnosis of leiomyosarcoma were enrolled. Preoperative evaluation included physical examination, Scrotal US, Abdominal CT and Scrotal MRI in selected cases. Patients underwent organ sparing surgery or orchiectomy in case of intraoperative FSE was positive for a local infiltration. Data collected were: age, presence of infiltration, length of the lesion, number of lesions, definitive histological outcome, pre and postoperative testosterone level. Follow up was performed with abdomen CT scan and scrotal US.
  
  
  RESULTS
  From January 2007 to December 2013, 23 patients (mean age: 64.7 yrs) were diagnosed with spermatic cord leiomyosarcoma. Each patients underwent scrotal US. 10 patients underwent radical orchiectomy and 13 patients underwent conservative surgery. Mean follow up was 36.5 months. 5 patients (21.7%) developed a recurrent disease, 18 patients (78.3%) had a negative follow up (mean time: 40.8 months). Statistical analysis reveals that there is a significant correlation between number of lesions, length of the lesions and recurrent disease.
  
  
  CONCLUSIONS
  Spermatic cord leiomyosarcoma is a rare disease. Conservative surgical treatment of spermatic cord leiomyosarcoma is a feasible therapeutic option for small, single and not infiltrating lesion.
authors.affiliation: Humanitas Mater Domini, Dept. of Urology, Castellanza-Varese, Italy. Electronic address: gioboz@yahoo.it.
authors.forename: G
authors.initials: G
authors.lastname: Bozzini
authors.affiliation: University Hospitals Leuven, Dept. of Urology, Leuven, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Albersen
authors.affiliation: Hospital Universitario 12 De Octubre, Dept. of Urology, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Romero Otero
authors.affiliation: Vienna General Hospital, Dept. of Urology, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Margreiter
authors.affiliation: Hospital Clínic De Barcelona, Dept. of Urology, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Garcia Cruz
authors.affiliation: University Hospital Zurich, Dept. of Urology, Zurich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Mueller
authors.affiliation: Ludwig-Maximilians-University (LMU), Dept. of Urology, Munich, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Gratzke
authors.affiliation: Bagcilar Training & Research Hospital, Dept. of Urology, Istanbul, Turkey.
authors.forename: E C
authors.initials: EC
authors.lastname: Serefoglu
authors.affiliation: Hospital Universitario Puerta De Hierro-Majadahonda, Dept. of Urology, Madrid, Spain.
authors.forename: J I
authors.initials: JI
authors.lastname: Martinez Salamanca
authors.affiliation: University of Naples Federico II, Dept. of Urology, Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Verze
mesh_terms: D000368:Aged; D005240:Feasibility Studies; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy / Q000379:methods*; D061214:Patient Safety; D013085:Spermatic Cord; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Frozen section examination; Orchiectomy; Organ sparing surgery; Scrotal US; Spermatic cord leiomyosarcoma