title: Multichannel quartz crystal microbalance array: Fabrication, evaluation, application in biomarker detection.
abstract: A multichannel quartz crystal microbalance array (MQCM) with three pairs of gold electrodes was fabricated for detection of two biomarkers: acetone and nitric oxide (NO). The gold electrodes were deposited symmetrically on an AT-cut 10 MHz circular quartz plate using photolithography, sputtering, and lift-off technologies. The effect of gold layer thickness on MQCM performance was investigated and the optimized thickness was 101 nm. The simulation values of the electric parameters C0, Cq, Lq, and Rq in the Butterworth-Van Dike equivalent circuit for the MQCM device were 97 pF, 1.3 pF, 1.05 mH, and 9.8 Ω, respectively. Simulation values were in the theoretical range, which indicated that the fabricated MQCM device had good resonance performance. Two types of nanocomposites, titanium dioxide-multiwalled carbon nanotubes and cobalt (II)phthalocyanine-silica, were synthesized as sensing materials. The sensing mechanism is based on coordination adsorption of target molecules onto the sensing material, resulting in a resonant frequency shift of modified QCM sensor. A linear range from 4.33 to 129.75 ppmv for acetone was obtained and one from 5.75 to 103.45 ppbv for NO.
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials & Shenzhen Engineering Laboratory for Advance Technology of Ceramics, College of Materials Science and Engineering, Shenzhen University, Shenzhen, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Tao
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials & Shenzhen Engineering Laboratory for Advance Technology of Ceramics, College of Materials Science and Engineering, Shenzhen University, Shenzhen, China. Electronic address: lin.peng@szu.edu.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Lin
authors.affiliation: Software College, Shenzhen Institute of Information Technology, Shenzhen, China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Ai
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials & Shenzhen Engineering Laboratory for Advance Technology of Ceramics, College of Materials Science and Engineering, Shenzhen University, Shenzhen, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China.
authors.forename: Hairui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials & Shenzhen Engineering Laboratory for Advance Technology of Ceramics, College of Materials Science and Engineering, Shenzhen University, Shenzhen, China.
authors.forename: Shanming
authors.initials: S
authors.lastname: Ke
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials & Shenzhen Engineering Laboratory for Advance Technology of Ceramics, College of Materials Science and Engineering, Shenzhen University, Shenzhen, China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China. Electronic address: zengxier@szu.edu.cn.
authors.forename: Xierong
authors.initials: X
authors.lastname: Zeng
mesh_terms: D000096:Acetone / Q000032:analysis; D015415:Biomarkers / Q000032:analysis*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry; D009569:Nitric Oxide / Q000032:analysis; D009942:Organometallic Compounds / Q000737:chemistry; D058525:Quartz Crystal Microbalance Techniques; D012822:Silicon Dioxide / Q000737:chemistry; D014025:Titanium / Q000737:chemistry
chemical_list: D015415:Biomarkers; D007211:Indoles; D037742:Nanotubes, Carbon; D009942:Organometallic Compounds; D000096:Acetone; C009495:titanium dioxide; D009569:Nitric Oxide; C063633:cobalt phthalocyanine; D006046:Gold; D012822:Silicon Dioxide; D014025:Titanium
keywords: Acetone; Multichannel quartz crystal microbalance array; Multiwalled carbon nanotube; Nitric oxide