title: Near infrared light-responsive and injectable supramolecular hydrogels for on-demand drug delivery.
abstract: A near infrared (NIR) light-responsive supramolecular hydrogel consisting of α-cyclodextrin and poly(ethylene glycol)-modified dendrimer-encapsulated platinum nanoparticles was developed. Upon NIR irradiation, this hydrogel underwent a photothermo-sensitive degradation to release the entrapped therapeutic agents in an on-demand and dose-tunable fashion.
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, P. R. China. yycheng@mail.ustc.edu.cn qzhang@bio.ecnu.edu.cn.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, P. R. China. yycheng@mail.ustc.edu.cn qzhang@bio.ecnu.edu.cn.
authors.forename: Changping
authors.initials: C
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, P. R. China. yycheng@mail.ustc.edu.cn qzhang@bio.ecnu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, P. R. China. yycheng@mail.ustc.edu.cn qzhang@bio.ecnu.edu.cn.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D000069286:Bortezomib / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004354:Drug Screening Assays, Antitumor; D005334:Fever / Q000188:drug therapy; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage* / Q000737:chemistry / Q000528:radiation effects*; D007259:Infrared Rays; D046911:Macromolecular Substances / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D041681:NIH 3T3 Cells; D010984:Platinum / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D013329:Structure-Activity Relationship; D047391:alpha-Cyclodextrins / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D004337:Drug Carriers; D020100:Hydrogels; D046911:Macromolecular Substances; D047391:alpha-Cyclodextrins; D011092:Polyethylene Glycols; D010984:Platinum; D000069286:Bortezomib; C032613:alpha-cyclodextrin