title: Trigemino-hypoglossal somatic reflex in the pharmacological studies of nociception in orofacial area.
abstract: Disorders involving the orofacial area represent a major medical and social problem. They are a consequence of central nociceptive processes associated with stimulation of the trigeminal nerve nucleus. A rat model of trigeminal pain, utilizing tongue jerks evoked by electrical tooth pulp stimulation during perfusion of the cerebral ventricles with various neuropeptide solutions, can be used in the pharmacological studies of nociception in orofacial area. The investigated neuropeptides diffuse through the cerebroventricular lining producing an analgesic effect either directly, through the trigemino-hypoglossal reflex arc neurons or indirectly through the periaqueductal central gray, raphe nuclei or locus coeruleus neurons. The aim of this review is to present the effect of pharmacological activity of various neuropeptides affecting the transmission of the sensory information from the orofacial area on the example of trigemino-hypoglossal reflex in rats.
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University of Ulm, Ulm, Germany.
authors.forename: Marek
authors.initials: M
authors.lastname: Zubrzycki
authors.affiliation: Department of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Janecka
authors.affiliation: Department of Experimental Physiology, Chair of Experimental and Clinical Physiology, Medical University of Lodz, Lodz, Poland; maria.pawelska-zubrzycka@umed.lodz.pl.
authors.forename: Maria
authors.initials: M
authors.lastname: Zubrzycka
mesh_terms: D000818:Animals; D005157:Facial Pain / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009479:Neuropeptides / Q000494:pharmacology*; D059225:Nociception / Q000187:drug effects*; D051381:Rats; D012018:Reflex / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D013681:Tegmentum Mesencephali / Q000187:drug effects*; D014279:Trigeminal Nucleus, Spinal / Q000187:drug effects* / Q000502:physiology
chemical_list: D009479:Neuropeptides