title: The relationship between early-life environment, the epigenome and the microbiota.
abstract: Children exposed to early-life adversity carry a greater risk of poor health and disease into adulthood. This increased disease risk is shadowed by changes in the epigenome. Epigenetics can change gene expression to modify disease risk; unfortunately, how epigenetics are changed by the environment is unclear. It is known that the environment modifies the microbiota, and recent data indicate that the microbiota and the epigenome interact and respond to each other. Specifically, the microbiome may alter the epigenome through the production of metabolites. Investigating the relationship between the microbiome and the epigenome may provide novel understanding of the impact of early-life environment on long-term health.
authors.affiliation: Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.
authors.forename: Amber V
authors.initials: AV
authors.lastname: Majnik
authors.affiliation: Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Lane
mesh_terms: D002794:Choline / Q000096:biosynthesis; D002843:Chromatin / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D019175:DNA Methylation; D060467:Disease Resistance / Q000187:drug effects / Q000235:genetics; D044127:Epigenesis, Genetic / Q000187:drug effects*; D005232:Fatty Acids, Volatile / Q000096:biosynthesis; D005492:Folic Acid / Q000096:biosynthesis; D059647:Gene-Environment Interaction; D015894:Genome, Human; D006657:Histones / Q000235:genetics / Q000276:immunology; D006801:Humans; D017879:Isothiocyanates / Q000378:metabolism; D064307:Microbiota / Q000502:physiology*; D059808:Polyphenols / Q000096:biosynthesis; D019936:Probiotics / Q000378:metabolism / Q000494:pharmacology*; D011499:Protein Processing, Post-Translational / Q000187:drug effects*
chemical_list: D002843:Chromatin; D005232:Fatty Acids, Volatile; D006657:Histones; D017879:Isothiocyanates; D059808:Polyphenols; D005492:Folic Acid; D002794:Choline
keywords: early-life adversity; environment; epigenetic; epigenome; histone modification; metabolite; methylation; microbiome