title: The role of microparticles in inflammation and transfusion: A concise review.
abstract: Microparticles are small membrane-bound vesicles found in body fluids including peripheral blood. Microparticles are an intrinsic part of blood labile products delivered to transfused patients and have active roles in inflammation. They are delimited by a lipid bilayer composed mainly of phospholipids, cholesterol, membrane-associated proteins, intracellular components such as metabolic enzymes, proteins-involved in adhesion and fusion, cytoskeletal-associated proteins, surface glycoproteins and/or chemokines. Microparticles can trigger a pro-inflammatory message to neighbouring or target cells. Microparticles originating from platelets, leukocytes, erythrocytes, and endothelial cells are associated with a variety of pathophysiological conditions. This review summarises the role of Microparticles in modulating inflammation.
authors.affiliation: Etablissement Français du Sang Auvergne-Loire, Saint-Etienne, France; Université de Lyon, GIMAP-EA3064, Saint Etienne, France. Electronic address: fabrice.cognasse@efs.sante.fr.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Cognasse
authors.affiliation: Université de Lyon, GIMAP-EA3064, Saint Etienne, France.
authors.forename: Hind
authors.initials: H
authors.lastname: Hamzeh-Cognasse
authors.affiliation: Etablissement Français du Sang Auvergne-Loire, Saint-Etienne, France; Université de Lyon, GIMAP-EA3064, Saint Etienne, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Laradi
authors.affiliation: Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Ming-Li
authors.initials: ML
authors.lastname: Chou
authors.affiliation: International Consultancy in Blood Components Quality/Safety, Audit/Inspection and DDR Strategy, London, UK.
authors.forename: Jerard
authors.initials: J
authors.lastname: Seghatchian
authors.affiliation: Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
authors.forename: Thierry
authors.initials: T
authors.lastname: Burnouf
authors.affiliation: INSERM, U970, Paris Cardiovascular Research Center (PARCC), UMR-S970 Paris, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Boulanger
authors.affiliation: Université de Lyon, GIMAP-EA3064, Saint Etienne, France; Institut National de Transfusion Sanguine (INTS), Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Garraud
authors.affiliation: INSERM, U970, Paris Cardiovascular Research Center (PARCC), UMR-S970 Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Amabile
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000378:metabolism* / Q000473:pathology; D016913:Blood Component Transfusion; D055252:Cell-Derived Microparticles / Q000378:metabolism* / Q000473:pathology; D003599:Cytoskeleton / Q000378:metabolism / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology; D008051:Lipid Bilayers / Q000097:blood; D008565:Membrane Proteins / Q000097:blood
chemical_list: D008051:Lipid Bilayers; D008565:Membrane Proteins
keywords: Inflammation; MPs; Transfusion