title: Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity.
abstract: Diabetes mellitus is becoming an increasingly prevalent disease that concerns patients and healthcare professionals worldwide. Among many anti-diabetic agents in clinical uses, numerous reports are available on their altered pharmacokinetics because of changes in the expression of drug transporters and metabolic enzymes under diabetic states. These changes may affect the safety and efficacy of therapeutic agents and/or drug-drug interaction with co-administered agents. Therefore, the changes in transporter expression should be identified, and the underlying mechanisms should be clarified. This review summarizes the progress of recent studies on the alterations in important uptake and efflux transporters in liver of diabetic animals and their regulatory pathways.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road 501, Shanghai, 201203, China.
authors.forename: Leilei
authors.initials: L
authors.lastname: Ma
authors.affiliation: InCROM CHINA, Quyang Road 972, Shanghai, 200437, China.
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road 501, Shanghai, 201203, China.
authors.forename: Le
authors.initials: L
authors.lastname: Wang
authors.affiliation: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Bldg 51 Room 3172, Silver Spring, MD, 20993-0002, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Metabolism and Pharmacokinetics, Novartis Institute for Biomedical Research, Cambridge, MA, 02139, USA.
authors.forename: Xuena
authors.initials: X
authors.lastname: Lin
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road 501, Shanghai, 201203, China. guoyupan@hotmail.com.
authors.forename: Guoyu
authors.initials: G
authors.lastname: Pan
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D008099:Liver / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*
chemical_list: D026901:Membrane Transport Proteins