title: The Prognostic Nutritional Index Predicts Survival and Identifies Aggressiveness of Gastric Cancer.
abstract: Nutritional status has been associated with long-term outcomes in cancer patients. The prognostic nutritional index (PNI) is calculated by serum albumin concentration and absolute lymphocyte count, and it may be a surrogate biomarker for nutritional status and possibly predicts overall survival (OS) of gastric cancer. We evaluated the value of the PNI as a predictor for disease-free survival (DFS) in addition to OS in a cohort of 314 gastric cancer patients who underwent curative surgical resection. There were 77 patients in PNI-low group (PNI ≤ 47.3) and 237 patients in PNI-high group (PNI > 47.3). With a median follow-up of 36.5 mo, 5-yr DFS rates in PNI-low group and PNI-high group were 63.5% and 83.6% and 5-yr OS rates in PNI-low group and PNI-high group were 63.5% and 88.4%, respectively (DFS, P < 0.0001; OS, P < 0.0001). In the multivariate analysis, the only predictors for DFS were PNI, tumor-node-metastasis (TNM) stage, and perineural invasion, whereas the only predictors for OS were PNI, age, TNM stage, and perineural invasion. In addition, the PNI was independent of various inflammatory markers. In conclusion, the PNI is an independent prognostic factor for both DFS and OS, and provides additional prognostic information beyond pathologic parameters.
authors.affiliation: a Department of Medical Oncology/Hematology , Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
authors.forename: Wan Kyu
authors.initials: WK
authors.lastname: Eo
authors.affiliation: a Department of Medical Oncology/Hematology , Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
authors.forename: Hye Jung
authors.initials: HJ
authors.lastname: Chang
authors.affiliation: a Department of Medical Oncology/Hematology , Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
authors.forename: Jungho
authors.initials: J
authors.lastname: Suh
authors.affiliation: a Department of Medical Oncology/Hematology , Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
authors.forename: Jin
authors.initials: J
authors.lastname: Ahn
authors.affiliation: a Department of Medical Oncology/Hematology , Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
authors.forename: Jeong
authors.initials: J
authors.lastname: Shin
authors.affiliation: a Department of Medical Oncology/Hematology , Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
authors.forename: Joon-Young
authors.initials: JY
authors.lastname: Hur
authors.affiliation: b Department of Pathology , Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
authors.forename: Gou Young
authors.initials: GY
authors.lastname: Kim
authors.affiliation: c Department of Sasang Constitutional Medicine , Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
authors.forename: Sookyung
authors.initials: S
authors.lastname: Lee
authors.affiliation: c Department of Sasang Constitutional Medicine , Kyung Hee University Hospital at Gangdong , Seoul , Republic of Korea.
authors.forename: Sora
authors.initials: S
authors.lastname: Park
authors.affiliation: d Department of Medical Consilence , Graduate School, Dankook University , Yongin-si , Republic of Korea.
authors.forename: Sanghun
authors.initials: S
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009752:Nutritional Status / Q000502:physiology*; D010525:Peripheral Nerves / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate
chemical_list: D012709:Serum Albumin