title: Assessment of quality of life in epilepsy patients receiving anti-epileptic drugs in a tertiary care teaching hospital.
abstract: OBJECTIVE
  Health-related quality of life (QOL) is an important outcome in epilepsy treatment. Very few studies have been carried out on the quality of life in epilepsy (QOLIE-31) in India. The present study aimed to determine the level of health-related QOLIE-31 in patients of epilepsy.
  
  
  METHODS
  This was a cross-sectional, questionnaire-based study conducted in a tertiary care teaching hospital. Respondents were adults aged at least 18-year-old with a diagnosis of epilepsy. QOLIE-31 was used for collecting data on health-related QOL. The unpaired t-test or one-way analysis of variance was used to compare means of QOL scores between groups.
  
  
  RESULTS
  Totally, 60 patients of epilepsy were included in the study. The mean (standard deviation) total score of QOLIE-31 was 64.61. A score of cognitive and medication effect were significantly better in carbamazepine group as compared to valproate group.
  
  
  CONCLUSIONS
  Patients on monotherapy had a better QOL as compared to patients receiving polytherapy.
authors.affiliation: Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India.
authors.forename: Sonali A
authors.initials: SA
authors.lastname: Pimpalkhute
authors.affiliation: Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India.
authors.forename: Chaitali S
authors.initials: CS
authors.lastname: Bajait
authors.affiliation: Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India.
authors.forename: Ganesh N
authors.initials: GN
authors.lastname: Dakhale
authors.affiliation: Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India.
authors.forename: Smita D
authors.initials: SD
authors.lastname: Sontakke
authors.affiliation: Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India.
authors.forename: Kavita M
authors.initials: KM
authors.lastname: Jaiswal
authors.affiliation: Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India.
authors.forename: Parag
authors.initials: P
authors.lastname: Kinge
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D007194:India; D008297:Male; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014635:Valproic Acid / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid
keywords: Antiepiletic drugs; QOL; carbamazepine; phenytoin; seizure; valproate