title: [Study on inhibitory effect of calycosin on hepatic stellate cell activation in rats by up-regulating peroxisome proliferator-activated receptor γ].
abstract: To observe the effect of calycosin on the proliferation and activation of primary hepatic stellate cells (HSCs) in rats, and prove calycosin shows the effects through peroxisome proliferator-activated receptor γ(PPARγ) and farnesoid X receptor (FXR). The results indicated that calycosin could inhibit HSC proliferation and expressions of activation marker smooth muscle actin-α and type I collagen. With the increase in HSC activation time, FXR expression reduced, but with no notable impact from calycosin. Calycosin could up-regulate PPARγ expression and its nuclear transition in a concentration-dependent manner. Its prohibitory effect on HSC activation could be blocked by PPARγ antagonist. In conclusion, calycosin could inhibit HSC activation and proliferation, which may be related with the up-regulation of PPARγ signal pathway.
authors.forename: Jian
authors.initials: J
authors.lastname: Ping
authors.forename: Hong-yun
authors.initials: HY
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.forename: Gao-feng
authors.initials: GF
authors.lastname: Chen
authors.forename: Lie-ming
authors.initials: LM
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D055166:Hepatic Stellate Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D047495:PPAR gamma / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D004365:Drugs, Chinese Herbal; D007529:Isoflavones; D047495:PPAR gamma; D018160:Receptors, Cytoplasmic and Nuclear; D000099150:Receptor, Farnesoid X-Activated; C121707:7,3'-dihydroxy-4'-methoxyisoflavone