title: High Patient Satisfaction of a Hyaluronic Acid Filler Producing Enduring Full-Facial Volume Restoration: An 18-Month Open Multicenter Study.
abstract: BACKGROUND
  Volume restoration is an essential part of facial rejuvenation.
  
  
  OBJECTIVE
  To assess long-term full-facial volume restoration using HAEL Volume Lidocaine hyaluronic acid filler.
  
  
  METHODS
  An 18-month open study in 60 subjects with at least Grade 2 on the 4-point volume loss scale (VLS) for full face and at least 2 indications affected among chin, temporal areas, jawline, cheeks, cheekbones, and nasolabial folds (NLF). Performance was assessed by VLS, Lemperle rating scale (LRS), investigator Global Aesthetic Improvement Scale (GAIS), and 3-dimensional (3D) imaging.
  
  
  RESULTS
  Most subjects (71.6%) had 3 or 4 indications injected, most commonly cheekbones (96.7%) and NLF (93.3%). At 18 months, at least a 1-grade improvement in VLS was observed for full face (68.3% of subjects), chin (77.8%), temporal areas (73.7%), cheeks (66.6%), cheekbones (58.6%), jawline (43.1%), and NLF (71.4%; LRS). For all indications, more than 60% of the volume gained at 3 weeks was sustained at 18 months based on 3D digital imaging. At 18 months, 95.0% of subjects had improved full-face GAIS and all subjects were satisfied with their aesthetic outcome. One subject (1.6%) had treatment-related adverse events.
  
  
  CONCLUSIONS
  Full-facial volume restoration was well sustained over 18 months with high patient satisfaction and good tolerability.
authors.affiliation: *Universidade Federal de São Paulo (UNIFESP/EPM), São Paulo, Brazil; †Hospital das Clínicas da Universidade de São Paulo, São Paulo, Brazil; ‡Clinica Dermatologica Laura Buratini, São Paulo, Brazil; §Centro Dermatológico, Rio de Janeiro, Brazil; ‖Galderma R&D SNC, Sophia Antipolis, France.
authors.forename: Sergio
authors.initials: S
authors.lastname: Talarico
authors.forename: Ana P
authors.initials: AP
authors.lastname: Meski
authors.forename: Laura
authors.initials: L
authors.lastname: Buratini
authors.forename: Mônica
authors.initials: M
authors.lastname: Manela-Azulay
authors.forename: Helen
authors.initials: H
authors.lastname: Simpson
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Sidou
authors.forename: Nabil
authors.initials: N
authors.lastname: Kerrouche
mesh_terms: D000328:Adult; D000368:Aged; D003357:Cosmetic Techniques / Q000009:adverse effects; D000067548:Dermal Fillers / Q000008:administration & dosage* / Q000009:adverse effects; D004487:Edema / Q000209:etiology; D004890:Erythema / Q000209:etiology; D004954:Esthetics; D005145:Face; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D000067548:Dermal Fillers; D006820:Hyaluronic Acid