title: In situ iodination and X-ray crystal structure of a foldamer helix bundle.
abstract: We report here the efficient in situ iodination of tyrosine-type side-chains located within a foldamer helix bundle, permitting structure determination using single-wavelength anomalous diffraction (SAD) methods. We suggest that this simple method may be of use to those engaged in structural foldamer research as a potential solution to the phase problem.
authors.affiliation: Université de Bordeaux, CNRS, UMR 5248, CBMN, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France. g.guichard@iecb.u-bordeaux.fr.
authors.forename: Gavin William
authors.initials: GW
authors.lastname: Collie
authors.affiliation: Université de Bordeaux, CNRS, UMR 5248, CBMN, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France. g.guichard@iecb.u-bordeaux.fr.
authors.forename: Karolina
authors.initials: K
authors.lastname: Pulka-Ziach
authors.affiliation: Université de Bordeaux, CNRS, UMR 5248, CBMN, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France. g.guichard@iecb.u-bordeaux.fr.
authors.forename: Gilles
authors.initials: G
authors.lastname: Guichard
mesh_terms: D018360:Crystallography, X-Ray; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D007455:Iodine