title: Geometrically Precise Building Blocks: the Self-Assembly of β-Peptides.
abstract: Peptides comprised entirely of β-amino acids, or β-peptides, have attracted substantial interest over the past 25 years due to their unique structural and chemical characteristics. β-Peptides form well-defined secondary structures that exhibit different geometries compared with their α-peptide counterparts, giving rise to their foldamer classification. β-Peptide foldamers can be functionalized easily and are metabolically stable and, together with the predictable side-chain topography, have led to the design of a growing number of bioactive β-peptides with a range of biological targets. The strategic engineering of chemical and topographic properties has also led to the design of β-peptide mimics of higher-order oligomers. More recently, the ability of these peptides to self-assemble into complex structures of controlled geometries has been exploited in materials applications. The focus of this mini-review is on how the unique structural features of β-peptide assemblies have been exploited in the design of self-assembled proteomimetic bundles and nanomaterials.
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia.
authors.forename: Romila D
authors.initials: RD
authors.lastname: Gopalan
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Del Borgo
authors.affiliation: Department of Chemistry, School of Molecular Science, La Trobe University, Bundoora, VIC 3083, Australia.
authors.forename: Adam I
authors.initials: AI
authors.lastname: Mechler
authors.affiliation: School of Chemistry, Monash University, Clayton, VIC 3800, Australia.
authors.forename: Patrick
authors.initials: P
authors.lastname: Perlmutter
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia. Electronic address: mibel.aguilar@monash.edu.
authors.forename: Marie-Isabel
authors.initials: MI
authors.lastname: Aguilar
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary
chemical_list: D000596:Amino Acids; D007473:Ion Channels; D010455:Peptides