title: Vitamin D: can you have too much of a good thing in chronic kidney disease?
abstract: Recommendation of vitamin D supplements is common although there is little information regarding the definition of the upper limit of safety. Kusunoki et al. now publish interesting data of a novel mechanism by which excess 25-hydroxyvitamin D exerts adverse effects on the kidney, using unilateral ureteral obstruction in the mouse as a model of kidney disease. Their report provides a new mechanism to be assessed as a surrogate measure of vitamin D toxicity that may be clinically relevant.
authors.affiliation: School of Pharmacy and Medical Science, University of South Australia, Adelaide, South Australia, Australia.|Chemical Pathology, SA Pathology, Adelaide, South Australia, Australia.
authors.forename: Howard A
authors.initials: HA
authors.lastname: Morris
mesh_terms: D000818:Animals; D002112:Calcifediol; D019587:Dietary Supplements; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000139:chemically induced*; D014807:Vitamin D; D014808:Vitamin D Deficiency
chemical_list: D014807:Vitamin D; D002112:Calcifediol