title: Long-term Sequelae of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. A limited number of studies have reported the long-term patterns of SJS and TEN complications in patient populations over long follow-up periods. The aim of this retrospective study was to collect data on long-term sequelae in patients admitted for SJS, SJS/TEN overlap, or TEN between 1998 and 2012. Among all 102 patients eligible for analysis, the 2 most common sequelae were cutaneous and ocular problems, both with incidences of 44.1%. Visceral organ involvement was observed in 2 patients with irreversible deterioration of chronic kidney disease and in one patient with interstitial lung disease. Autoimmune disease was present in 6 patients: Sjögren's syndrome or Sjögren-like syndrome in 5 patients and concomitant systemic lupus erythematosus and Hashimoto thyroiditis in one patient.
authors.affiliation: Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, 10048 Taipei, Taiwan.
authors.forename: Che-Wen
authors.initials: CW
authors.lastname: Yang
authors.forename: Yung-Tsu
authors.initials: YT
authors.lastname: Cho
authors.forename: Kai-Lung
authors.initials: KL
authors.lastname: Chen
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Hsiang-Lin
authors.initials: HL
authors.lastname: Song
authors.forename: Chia-Yu
authors.initials: CY
authors.lastname: Chu
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology*; D005128:Eye Diseases / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D050031:Hashimoto Disease / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D017563:Lung Diseases, Interstitial / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000453:epidemiology; D012871:Skin Diseases / Q000175:diagnosis / Q000453:epidemiology*; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors