title: Pneumococcal Disease Prevention Among Adults: Strategies for the Use of Pneumococcal Vaccines.
abstract: Use of the pneumococcal conjugate vaccines among children in the U.S. since 2000 has dramatically reduced pneumococcal disease burden among adults. Significant vaccine-preventable morbidity and mortality from pneumococcal infections still remains, especially among older adults. The U.S. Advisory Committee on Immunization Practices (ACIP) has recently recommended the routine use of both pneumococcal conjugate (PCV13) and polysaccharide vaccines (PPSV23) for adults ≥65 years. These recommendations were based on the remaining burden of illness among adults and the importance of non-bacteremic pneumonia prevention in light of new evidence confirming the efficacy of PCV13 to prevent pneumococcal pneumonia among older adults. This paper reviews the evidence that led ACIP to make recommendations for PCV13 and PPSV23 use among adults, and highlights potential gaps to be addressed by future studies to inform adult vaccination policy. The changing epidemiology of invasive pneumococcal disease and pneumonia should be closely monitored to evaluate the effectiveness and continued utility of the current vaccination strategy, and to identify future directions for pneumococcal disease prevention among older adults.
authors.affiliation: National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: tpilishvili@cdc.gov.
authors.forename: Tamara
authors.initials: T
authors.lastname: Pilishvili
authors.affiliation: Department of Medicine and Center for Community Health, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Bennett
mesh_terms: D000368:Aged; D006291:Health Policy; D006801:Humans; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D011018:Pneumonia, Pneumococcal / Q000453:epidemiology* / Q000517:prevention & control*; D011159:Population Surveillance; D017410:Practice Guidelines as Topic; D014481:United States; D018074:Vaccines, Conjugate
chemical_list: C538862:13-valent pneumococcal vaccine; C414006:23-valent pneumococcal capsular polysaccharide vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate