title: Oligometastatic non-small cell lung cancer (NSCLC): adrenal metastases. Experience in a single institution.
abstract: Though the actual incidence of an adrenal oligometastasis is between 1.5 and 3.5 %, secondary adrenal neoplasms occur in less than 10 % patients with non-small cell lung cancer (NSCLC). According to 7° ed. TNM staging system, the presence of an adrenal metastasis (M1b disease) configures stage IV, which is usually associated with poor prognosis. We evaluated if metastasectomy in selected patients with oligometastatic disease improves overall survival. A 15-year retrospective study concerning patients with NSCLC was performed and an oligometastatic disease was found in 1.61 % of the patients. 18 adrenalectomies were performed. Clustering the population according to different therapeutic strategies, a benefit in terms of survival was found in patients who underwent adrenalectomy. A statistical relevance was found, indeed, between adrenalectomy (p < 0.01), metachronous disease (p < 0.01), the presence of a homolateral disease (p < 0.05) and overall survival. Adrenalectomy should be offered in selected patients with oligometastatic disease.
authors.affiliation: Department of General and Thoracic Surgery, University Hospital "SS. Annunziata", Chieti, Italy. mir87mb@libero.it.
authors.forename: Mirko
authors.initials: M
authors.lastname: Barone
authors.affiliation: Department of General and Thoracic Surgery, University Hospital "SS. Annunziata", Chieti, Italy.
authors.forename: Decio
authors.initials: D
authors.lastname: Di Nuzzo
authors.affiliation: Department of General and Thoracic Surgery, University Hospital "SS. Annunziata", Chieti, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cipollone
authors.affiliation: Department of General and Thoracic Surgery, University Hospital "SS. Annunziata", Chieti, Italy.
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Camplese
authors.affiliation: Department of General and Thoracic Surgery, University Hospital "SS. Annunziata", Chieti, Italy.
authors.forename: Felice
authors.initials: F
authors.lastname: Mucilli
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D000315:Adrenalectomy; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Adrenalectomy; Lung cancer; Metastatic disease