title: Plasticity of hematopoietic stem cells.
abstract: Almost two decades ago, a number of cell culture and preclinical transplantation studies suggested the striking concept of the tissue-reconstituting ability of hematopoietic stem cells (HSCs). While this heralded an exciting time of radically new therapies for disorders of many organs and tissues, the concept was soon mired by controversy and remained dormant. This chapter provides a brief review of evidence for HSC plasticity including our findings based on single HSC transplantation in mouse. These studies strongly support the concept that HSCs are pluripotent and may be the source for the majority, if not all, of the cell types in our body.
authors.affiliation: Medical University of South Carolina, 165 Ashley Ave, MSC 908, Charleston, SC 2C9425, USA. Electronic address: ogawam@musc.edu.
authors.forename: Makio
authors.initials: M
authors.lastname: Ogawa
authors.affiliation: Medical University of South Carolina, 165 Ashley Ave, MSC 908, Charleston, SC 2C9425, USA; Ralph H. Johnson Department of Veterans Affairs Medical Center, 109 Bee Street, Research (151), Charleston, SC 29425, USA; Hollings Cancer Center, 86 Jonathan Lucas St, Charleston, SC 29425, USA.
authors.forename: Amanda C
authors.initials: AC
authors.lastname: LaRue
authors.affiliation: Medical University of South Carolina, 165 Ashley Ave, MSC 908, Charleston, SC 2C9425, USA; Hollings Cancer Center, 86 Jonathan Lucas St, Charleston, SC 29425, USA.
authors.forename: Meenal
authors.initials: M
authors.lastname: Mehrotra
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage / Q000502:physiology*; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology; D022781:Hepatocytes / Q000166:cytology / Q000502:physiology; D006801:Humans; D051379:Mice; D058628:Myofibroblasts / Q000166:cytology / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology
keywords: Hematopoietic stem cells (HSCs); Plasticity; Stem cells; Tissue regeneration; Transplantation