title: The role of chemotherapy and operation on lymphocytes accumulation in peripheral blood obtained from patients with oral squamous cell carcinoma.
abstract: The "Cancer Immunoediting" concept has provided critical insights suggesting dual functions of immune system during the cancer initiation and development. However, the dynamics and roles of CD4(+) and CD8(+) T cells, CD19(+) B cells, and CD56(+) NK cells in the patients with oral squamous cell carcinoma during treatment remain unclear. A total of 43 patients with OSCC were divided into different groups according to different clinical factors (TNM staging, pathological patterns, age and genders) for assessment of relations with CD3(+)CD4(+) T cells, CD3(+)CD8(+) T cells, CD3(-)CD19(+) B cells and CD3(-)CD16(+)CD56(+) NK cells and different chemotherapy and radical operation. The expression of CD3(+)CD4(+) T cells were significantly increased in advanced tumor stage, large tumor size and positive lymph nodes metastasis, compared to that in early groups. The accumulation of CD3(+)CD4(+) T cells were significantly increased in OSCC patients received 2 cycles CT and radical operation. Moreover, the accumulation of CD3(+)CD8(+) T cells were significantly decreased in OSCC patients received 2 cycles CT and radical operation. The distribution of circulating CD3(-)CD19(+) B cells was related with radical operation in patients with OSCC. This study indicate that CD4(+) T cells have opposing roles in OSCC progression and outcomes, which provides new insights relevant for the development of effective cancer immunotherapeutic approaches. 2 cycles TP regime chemotherapy and radical therapy may contribute to increase the effects of anti-tumor immunity on patients with OSCC.
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Ping
authors.initials: P
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Jiafeng
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Clinical Laboratory, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Lichun
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Kun
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Guiquan
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Chuan
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Yongcong
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Head and Neck Oncology Surgery, Sichuan Cancer Hospital, No.55, Sec.4, Renminnan Road, Chengdu, 610041 Sichuan People's Republic Ofchina.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Wang
keywords: Chemotherapy; Immune subset; Oral squamous cell carcinoma; Radical operation