title: Beyond ion-conduction: Channel-dependent and -independent roles of TRP channels during development and tissue homeostasis.
abstract: Transient receptor potential (TRP) channels comprise a family of cation channels implicated in a variety of cellular processes, including proliferation, cell migration and cell survival. As a consequence, members of this ion family play prominent roles during embryonic development, tissue maintenance and cancer progression. Although most TRP channels are non-selective, many cellular responses, mediated by TRP channels, appear to be calcium-dependent. In addition, there is mounting evidence for channel-independent roles for TRP channels. In this review, we will discuss how both these channel-dependent and -independent mechanisms affect cellular programs essential during embryonic development, and how perturbations in these pathways contribute to a variety of pathologies. This article is part of a Special Issue entitled: Calcium and Cell Fate. Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen.
authors.affiliation: Laboratory of Pediatric Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: kirsten.vrenken@radboudumc.nl.
authors.forename: Kirsten S
authors.initials: KS
authors.lastname: Vrenken
authors.affiliation: Division of Cell Biology, The Netherlands Cancer Institute NKI-AVL, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: K.Jalink@nki.nl.
authors.forename: Kees
authors.initials: K
authors.lastname: Jalink
authors.affiliation: Laboratory of Pediatric Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: frankn.vanleeuwen@radboudumc.nl.
authors.forename: Frank N
authors.initials: FN
authors.lastname: van Leeuwen
authors.affiliation: Laboratory of Pediatric Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: jeroen.middelbeek@radboudumc.nl.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Middelbeek
mesh_terms: D002118:Calcium / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D005810:Multigene Family; D009928:Organ Specificity; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000378:metabolism*
chemical_list: D050051:Transient Receptor Potential Channels; D002118:Calcium
keywords: Calcium; Embryonic development; Epithelial-mesenchymal transition (EMT); TRP channels; Tissue homeostasis